A test of the role of the medial temporal lobe in single-word decoding.

PubMed

Osipowicz, Karol; Rickards, Tyler; Shah, Atif; Sharan, Ashwini; Sperling, Michael; Kahn, Waseem; Tracy, Joseph

2011-01-15

The degree to which the MTL system contributes to effective language skills is not well delineated. We sought to determine if the MTL plays a role in single-word decoding in healthy, normal skilled readers. The experiment follows from the implications of the dual-process model of single-word decoding, which provides distinct predictions about the nature of MTL involvement. The paradigm utilized word (regular and irregularly spelled words) and pseudoword (phonetically regular) stimuli that differed in their demand for non-lexical as opposed lexical decoding. The data clearly showed that the MTL system was not involved in single word decoding in skilled, native English readers. Neither the hippocampus nor the MTL system as a whole showed significant activation during lexical or non-lexical based decoding. The results provide evidence that lexical and non-lexical decoding are implemented by distinct but overlapping neuroanatomical networks. Non-lexical decoding appeared most uniquely associated with cuneus and fusiform gyrus activation biased toward the left hemisphere. In contrast, lexical decoding appeared associated with right middle frontal and supramarginal, and bilateral cerebellar activation. Both these decoding operations appeared in the context of a shared widespread network of activations including bilateral occipital cortex and superior frontal regions. These activations suggest that the absence of MTL involvement in either lexical or non-lexical decoding appears likely a function of the skilled reading ability of our sample such that whole-word recognition and retrieval processes do not utilize the declarative memory system, in the case of lexical decoding, and require only minimal analysis and recombination of the phonetic elements of a word, in the case of non-lexical decoding. Copyright © 2010 Elsevier Inc. All rights reserved.

A Test of the Role of the Medial Temporal Lobe in Single-Word Decoding

PubMed Central

Osipowicz, Karol; Rickards, Tyler; Shah, Atif; Sharan, Ashwini; Sperling, Michael; Kahn, Waseem; Tracy, Joseph

2012-01-01

The degree to which the MTL system contributes to effective language skills is not well delineated. We sought to determine if the MTL plays a role in single-word decoding in healthy, normal skilled readers. The experiment follows from the implications of the dual-process model of single-word decoding, which provides distinct predictions about the nature of MTL involvement. The paradigm utilized word (regular and irregularly spelled words) and pseudoword (phonetically regular) stimuli that differed in their demand for non-lexical as opposed lexical decoding. The data clearly showed that the MTL system was not involved in single word decoding in skilled, native English readers. Neither the hippocampus, nor the MTL system as a whole showed significant activation during lexical or non-lexical based decoding. The results provide evidence that lexical and non-lexical decoding are implemented by distinct but overlapping neuroanatomical networks. Non-lexical decoding appeared most uniquely associated with cuneus and fusiform gyrus activation biased toward the left hemisphere. In contrast, lexical decoding appeared associated with right middle frontal and supramarginal, and bilateral cerebellar activation. Both these decoding operations appeared in the context of a shared widespread network of activations including bilateral occipital cortex and superior frontal regions. These activations suggest that the absence of MTL involvement in either lexical or non-lexical decoding appears likely a function of the skilled reading ability of our sample such that whole-word recognition and retrieval processes do not utilize the declarative memory system, in the case of lexical decoding, and require only minimal analysis and recombination of the phonetic elements of a word, in the case of non-lexical decoding. PMID:20884357

Tau and β-Amyloid Are Associated with Medial Temporal Lobe Structure, Function, and Memory Encoding in Normal Aging

DOE Office of Scientific and Technical Information (OSTI.GOV)

Marks, Shawn M.; Lockhart, Samuel N.; Baker, Suzanne L.

Normal aging is associated with a decline in episodic memory and also with aggregation of the β-amyloid (Aβ) and tau proteins and atrophy of medial temporal lobe (MTL) structures crucial to memory formation. Although some evidence suggests that Aβ is associated with aberrant neural activity, the relationships among these two aggregated proteins, neural function, and brain structure are poorly understood. Using in vivo human Aβ and tau imaging, we demonstrate that increased Aβ and tau are both associated with aberrant fMRI activity in the MTL during memory encoding in cognitively normal older adults. This pathological neural activity was in turnmore » associated with worse memory performance and atrophy within the MTL. A mediation analysis revealed that the relationship with regional atrophy was explained by MTL tau. These findings broaden the concept of cognitive aging to include evidence of Alzheimer’s disease-related protein aggregation as an underlying mechanism of age-related memory impairment.« less

Source recognition by stimulus content in the MTL.

PubMed

Park, Heekyeong; Abellanoza, Cheryl; Schaeffer, James; Gandy, Kellen

2014-03-17

Source memory is considered to be the cornerstone of episodic memory that enables us to discriminate similar but different events. In the present fMRI study, we investigated whether neural correlates of source retrieval differed by stimulus content in the medial temporal lobe (MTL) when the item and context had been integrated as a perceptually unitized entity. Participants were presented with a list of items either in verbal or pictorial form overlaid on a colored square and instructed to integrate both the item and context into a single image. At test, participants judged the study status of test items and the color in which studied items were presented. Source recognition invariant of stimulus content elicited retrieval activity in both the left anterior hippocampus extending to the perirhinal cortex and the right posterior hippocampus. Word-selective source recognition was related to activity in the left perirhinal cortex, whereas picture-selective source recognition was identified in the left posterior hippocampus. Neural activity sensitive to novelty detection common to both words and pictures was found in the left anterior and right posterior hippocampus. Novelty detection selective to words was associated with the left perirhinal cortex, while activity sensitive to new pictures was identified in the bilateral hippocampus and adjacent MTL cortices, including the parahippocampal, entorhinal, and perirhinal cortices. These findings provide further support for the integral role of the hippocampus both in source recognition and in detection of new stimuli across stimulus content. Additionally, novelty effects in the MTL reveal the integral role of the MTL cortex as the interface for processing new information. Collectively, the present findings demonstrate the importance of the MTL for both previously experienced and novel events. Copyright © 2014 Elsevier B.V. All rights reserved.

Thermostability of native and pegylated Myceliophthora thermophila laccase in aqueous and mixed solvents.

PubMed

López-Cruz, J I; Viniegra-Gonzalez, G; Hernández-Arana, A

2006-01-01

A commercial preparation of laccase (EC 1.10.3.2), cloned from Myceliophthora thermophila and expressed in Aspergillus oryzae (MtL), was purified and modified by conjugation with poly(ethylene glycol) (M(r) = 5000) and is labeled PEG-MtL. Native enzyme was found to have a molecular mass of 80 kDa, as determined by gel filtration, and 110 kDa, by SDS-PAGE. The oxidative dimerization of 2,6-dimethoxyphenol (DMP) to produce the corresponding dibenzoquinone was catalyzed by MtL in a manner comparable to that for a diffusion-controlled reaction (k(cat)/K(M) approximately = 10(8) M(-)(1) s(-)(1) and E(a) approximately = 18 kJ M(-)(1)). PEG-MtL was found, by TNBS titration, to have blocked 54% of lysine groups; its hydrodynamic and charge properties were different from those of MtL. Catalytic efficiency (k(cat)/K(M)) of PEG-MtL was similar to that of MtL with DMP as substrate; however, k(cat)/K(M) was 2-fold reduced for the reaction in which 2',2-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) is oxidized to form a radical cation. E(a) values were similar in both enzyme preparations when assayed in buffered solutions. Far-UV CD spectra were similar for MtL and PEG-MtL and consistent with a protein rich in beta-sheet structure with negligible content of alpha-helices. A blue shift of near-UV CD spectrum for PEG-MtL as compared to MtL was consistent with the decreased polarity of the tyrosyl side chains upon PEG conjugation. Also the blue band of the copper active site was shifted from lambda approximately 610 nm (MtL) to lambda approximately 575 nm (PEG-MtL). Scanning microcalorimetry showed small denaturation enthalpies (6.3 and 7.5 J g(-)(1) for MtL and PEG-MtL, respectively), indicating the high stability of the beta-sheet folding pattern of laccases. However, PEG-MtL proved to be more stable, its half-denaturation temperature being 2 degrees C higher than that of MtL. In 30% alcohol, pegylated laccase showed slower enzyme-activity decay rates than the unmodified enzyme; this behavior was caused by a decrease in the activation entropy of the denaturation reaction. Results can be explained by entropic stabilization by PEG conjugation because of the restricted motion of some surface amino acid side chains, which results in a more stable active site.

Memory for fearful faces across development: specialization of amygdala nuclei and medial temporal lobe structures.

PubMed

Pinabiaux, Charlotte; Hertz-Pannier, Lucie; Chiron, Catherine; Rodrigo, Sébastian; Jambaqué, Isabelle; Noulhiane, Marion

2013-01-01

Enhanced memory for emotional faces is a significant component of adaptive social interactions, but little is known on its neural developmental correlates. We explored the role of amygdaloid complex (AC) and medial temporal lobe (MTL) in emotional memory recognition across development, by comparing fMRI activations of successful memory encoding of fearful and neutral faces in children (n = 12; 8-12 years) and adolescents (n = 12; 13-17 years). Memory for fearful faces was enhanced compared with neutral ones in adolescents, as opposed to children. In adolescents, activations associated with successful encoding of fearful faces were centered on baso-lateral AC nuclei, hippocampus, enthorhinal and parahippocampal cortices. In children, successful encoding of fearful faces relied on activations of centro-mesial AC nuclei, which was not accompanied by functional activation of MTL memory structures. Successful encoding of neutral faces depended on activations in anterior MTL region (hippocampal head and body) in adolescents, but more posterior ones (hippocampal tail and parahippocampal cortex) in children. In conclusion, two distinct functional specializations emerge from childhood to adolescence and result in the enhancement of memory for these particular stimuli: the specialization of baso-lateral AC nuclei, which is associated with the expertise in processing emotional facial expression, and which is intimately related to the specialization of MTL memory network. How the interplay between specialization of AC nuclei and of MTL memory structures is fundamental for the edification of social interactions remains to be elucidated.

Memory for fearful faces across development: specialization of amygdala nuclei and medial temporal lobe structures

PubMed Central

Pinabiaux, Charlotte; Hertz-Pannier, Lucie; Chiron, Catherine; Rodrigo, Sébastian; Jambaqué, Isabelle; Noulhiane, Marion

2013-01-01

Enhanced memory for emotional faces is a significant component of adaptive social interactions, but little is known on its neural developmental correlates. We explored the role of amygdaloid complex (AC) and medial temporal lobe (MTL) in emotional memory recognition across development, by comparing fMRI activations of successful memory encoding of fearful and neutral faces in children (n = 12; 8–12 years) and adolescents (n = 12; 13–17 years). Memory for fearful faces was enhanced compared with neutral ones in adolescents, as opposed to children. In adolescents, activations associated with successful encoding of fearful faces were centered on baso-lateral AC nuclei, hippocampus, enthorhinal and parahippocampal cortices. In children, successful encoding of fearful faces relied on activations of centro-mesial AC nuclei, which was not accompanied by functional activation of MTL memory structures. Successful encoding of neutral faces depended on activations in anterior MTL region (hippocampal head and body) in adolescents, but more posterior ones (hippocampal tail and parahippocampal cortex) in children. In conclusion, two distinct functional specializations emerge from childhood to adolescence and result in the enhancement of memory for these particular stimuli: the specialization of baso-lateral AC nuclei, which is associated with the expertise in processing emotional facial expression, and which is intimately related to the specialization of MTL memory network. How the interplay between specialization of AC nuclei and of MTL memory structures is fundamental for the edification of social interactions remains to be elucidated. PMID:24399958

The medial temporal lobe-conduit of parallel connectivity: a model for attention, memory, and perception.

PubMed

Mozaffari, Brian

2014-01-01

Based on the notion that the brain is equipped with a hierarchical organization, which embodies environmental contingencies across many time scales, this paper suggests that the medial temporal lobe (MTL)-located deep in the hierarchy-serves as a bridge connecting supra- to infra-MTL levels. Bridging the upper and lower regions of the hierarchy provides a parallel architecture that optimizes information flow between upper and lower regions to aid attention, encoding, and processing of quick complex visual phenomenon. Bypassing intermediate hierarchy levels, information conveyed through the MTL "bridge" allows upper levels to make educated predictions about the prevailing context and accordingly select lower representations to increase the efficiency of predictive coding throughout the hierarchy. This selection or activation/deactivation is associated with endogenous attention. In the event that these "bridge" predictions are inaccurate, this architecture enables the rapid encoding of novel contingencies. A review of hierarchical models in relation to memory is provided along with a new theory, Medial-temporal-lobe Conduit for Parallel Connectivity (MCPC). In this scheme, consolidation is considered as a secondary process, occurring after a MTL-bridged connection, which eventually allows upper and lower levels to access each other directly. With repeated reactivations, as contingencies become consolidated, less MTL activity is predicted. Finally, MTL bridging may aid processing transient but structured perceptual events, by allowing communication between upper and lower levels without calling on intermediate levels of representation.

Bayesian multi-task learning for decoding multi-subject neuroimaging data.

PubMed

Marquand, Andre F; Brammer, Michael; Williams, Steven C R; Doyle, Orla M

2014-05-15

Decoding models based on pattern recognition (PR) are becoming increasingly important tools for neuroimaging data analysis. In contrast to alternative (mass-univariate) encoding approaches that use hierarchical models to capture inter-subject variability, inter-subject differences are not typically handled efficiently in PR. In this work, we propose to overcome this problem by recasting the decoding problem in a multi-task learning (MTL) framework. In MTL, a single PR model is used to learn different but related "tasks" simultaneously. The primary advantage of MTL is that it makes more efficient use of the data available and leads to more accurate models by making use of the relationships between tasks. In this work, we construct MTL models where each subject is modelled by a separate task. We use a flexible covariance structure to model the relationships between tasks and induce coupling between them using Gaussian process priors. We present an MTL method for classification problems and demonstrate a novel mapping method suitable for PR models. We apply these MTL approaches to classifying many different contrasts in a publicly available fMRI dataset and show that the proposed MTL methods produce higher decoding accuracy and more consistent discriminative activity patterns than currently used techniques. Our results demonstrate that MTL provides a promising method for multi-subject decoding studies by focusing on the commonalities between a group of subjects rather than the idiosyncratic properties of different subjects. Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.

Medial temporal lobe reinstatement of content-specific details predicts source memory

PubMed Central

Liang, Jackson C.; Preston, Alison R.

2016-01-01

Leading theories propose that when remembering past events, medial temporal lobe (MTL) structures reinstate the neural patterns that were active when those events were initially encoded. Accurate reinstatement is hypothesized to support detailed recollection of memories, including their source. While several studies have linked cortical reinstatement to successful retrieval, indexing reinstatement within the MTL network and its relationship to memory performance has proved challenging. Here, we addressed this gap in knowledge by having participants perform an incidental encoding task, during which they visualized people, places, and objects in response to adjective cues. During a surprise memory test, participants saw studied and novel adjectives and indicated the imagery task they performed for each adjective. A multivariate pattern classifier was trained to discriminate the imagery tasks based on functional magnetic resonance imaging (fMRI) responses from hippocampus and MTL cortex at encoding. The classifier was then tested on MTL patterns during the source memory task. We found that MTL encoding patterns were reinstated during successful source retrieval. Moreover, when participants made source misattributions, errors were predicted by reinstatement of incorrect source content in MTL cortex. We further observed a gradient of content-specific reinstatement along the anterior-posterior axis of hippocampus and MTL cortex. Within anterior hippocampus, we found that reinstatement of person content was related to source memory accuracy, whereas reinstatement of place information across the entire hippocampal axis predicted correct source judgments. Content-specific reinstatement was also graded across MTL cortex, with PRc patterns evincing reactivation of people and more posterior regions, including PHc, showing evidence for reinstatement of places and objects. Collectively, these findings provide key evidence that source recollection relies on reinstatement of past experience within the MTL network. PMID:28029355

The mating type-like loci of Candida glabrata.

PubMed

Yáñez-Carrillo, Patricia; Robledo-Márquez, Karina A; Ramírez-Zavaleta, Candy Y; De Las Peñas, Alejandro; Castaño, Irene

2014-01-01

Candida glabrata, a haploid and opportunistic fungal pathogen that has not known sexual cycle, has conserved the majority of the genes required for mating and cell type identity. The C. glabrata genome contains three mating-type-like loci called MTL1, MTL2 and MTL3. The three loci encode putative transcription factors, a1, α1 and α2 that regulate cell type identity and sexual reproduction in other fungi like the closely related Saccharomyces cerevisiae. MTL1 can contain either a or α information. MTL2, which contains a information and MTL3 with α information, are relatively close to two telomeres. MTL1 and MTL2 are transcriptionally active, while MTL3 is subject to an incomplete silencing nucleated at the telomere that depends on the silencing proteins Sir2, Sir3, Sir4, yKu70/80, Rif1, Rap1 and Sum1. C. glabrata does not seem to maintain cell type identity, as cell type-specific genes are expressed regardless of the type (or even absence) of mating information. These data highlight important differences in the control of mating and cell type identity between the non-pathogenic yeast S. cerevisiae and C. glabrata, which might explain the absence of a sexual cycle in C. glabrata. The fact that C. glabrata has conserved the vast majority of the genes involved in mating might suggest that some of these genes perhaps have been rewired to control other processes important for the survival inside the host as a commensal or as a human pathogen. This manuscript is part of the series of works presented at the "V International Workshop: Molecular genetic approaches to the study of human pathogenic fungi" (Oaxaca, Mexico, 2012). Copyright © 2013 Revista Iberoamericana de Micología. Published by Elsevier Espana. All rights reserved.

Staphylococcal phosphoenolpyruvate-dependent phosphotransferase system: purification and characterization of the mannitol-specific enzyme III/sup mtl/ of Staphylococcus aureus and Staphylococcus carnosus and homology with the enzyme II/sup mtl/ of Escherichia coli

DOE Office of Scientific and Technical Information (OSTI.GOV)

Reiche, B.; Frank, R.; Deutscher, J.

1988-08-23

Enzyme III/sup mtl/ is part of the mannitol phosphotransferase system of Staphylococcus aureus and Staphylococcus carnosus and is phosphorylated by phosphoenolpyruvate in a reaction sequence requiring enzyme I (phosphoenolpyruvate-protein phosphotransferase) and the histidine-containing protein HPr. In this paper, the authors report the isolation of III/sup mtl/ from both S. aureus and S. carnosus and the characterization of the active center. After phosphorylation of III/sup mtl/ with (/sup 32/P)PEP, enzyme I, and HPr, the phosphorylated protein was cleaved with endoproteinase GLu(C). The amino acid sequence of the S. aureus peptide carrying the phosphoryl group was found to be Gln-Val-Val-Ser-Thr-Phe-Met-Gly-Asn-Gly-Leu-Ala-Ile-Pro-His-Gly-Thr-Asp-Asp. The correspondingmore » peptide from S. carnosus shows an equal sequence except that the first residue is Ala instead of Gln. These peptides both contain a single histidyl residue which they assume to carry the phosphoryl group. All proteins of the PTS so far investigated indeed carry the phosphoryl group attached to a histidyl residue. According to sodium dodecyl sulfate gels, the molecular weight of the III/sup mtl/ proteins was found to be 15,000. They have also determined the N-terminal sequence of both proteins. Comparison of the III/sup mtl/ peptide sequences and the C-terminal part of the enzyme II/sup mtl/ of Escherichia coli reveals considerable sequence homology, which supports the suggestion that II/sup mtl/ of E. coli is a fusion protein of a soluble III protein with a membrane-bound enzyme II.« less

Medial temporal lobe reinstatement of content-specific details predicts source memory.

PubMed

Liang, Jackson C; Preston, Alison R

2017-06-01

Leading theories propose that when remembering past events, medial temporal lobe (MTL) structures reinstate the neural patterns that were active when those events were initially encoded. Accurate reinstatement is hypothesized to support detailed recollection of memories, including their source. While several studies have linked cortical reinstatement to successful retrieval, indexing reinstatement within the MTL network and its relationship to memory performance has proved challenging. Here, we addressed this gap in knowledge by having participants perform an incidental encoding task, during which they visualized people, places, and objects in response to adjective cues. During a surprise memory test, participants saw studied and novel adjectives and indicated the imagery task they performed for each adjective. A multivariate pattern classifier was trained to discriminate the imagery tasks based on functional magnetic resonance imaging (fMRI) responses from hippocampus and MTL cortex at encoding. The classifier was then tested on MTL patterns during the source memory task. We found that MTL encoding patterns were reinstated during successful source retrieval. Moreover, when participants made source misattributions, errors were predicted by reinstatement of incorrect source content in MTL cortex. We further observed a gradient of content-specific reinstatement along the anterior-posterior axis of hippocampus and MTL cortex. Within anterior hippocampus, we found that reinstatement of person content was related to source memory accuracy, whereas reinstatement of place information across the entire hippocampal axis predicted correct source judgments. Content-specific reinstatement was also graded across MTL cortex, with PRc patterns evincing reactivation of people and more posterior regions, including PHc, showing evidence for reinstatement of places and objects. Collectively, these findings provide key evidence that source recollection relies on reinstatement of past experience within the MTL network. Copyright © 2016 Elsevier Ltd. All rights reserved.

The medial temporal lobe—conduit of parallel connectivity: a model for attention, memory, and perception

PubMed Central

Mozaffari, Brian

2014-01-01

Based on the notion that the brain is equipped with a hierarchical organization, which embodies environmental contingencies across many time scales, this paper suggests that the medial temporal lobe (MTL)—located deep in the hierarchy—serves as a bridge connecting supra- to infra—MTL levels. Bridging the upper and lower regions of the hierarchy provides a parallel architecture that optimizes information flow between upper and lower regions to aid attention, encoding, and processing of quick complex visual phenomenon. Bypassing intermediate hierarchy levels, information conveyed through the MTL “bridge” allows upper levels to make educated predictions about the prevailing context and accordingly select lower representations to increase the efficiency of predictive coding throughout the hierarchy. This selection or activation/deactivation is associated with endogenous attention. In the event that these “bridge” predictions are inaccurate, this architecture enables the rapid encoding of novel contingencies. A review of hierarchical models in relation to memory is provided along with a new theory, Medial-temporal-lobe Conduit for Parallel Connectivity (MCPC). In this scheme, consolidation is considered as a secondary process, occurring after a MTL-bridged connection, which eventually allows upper and lower levels to access each other directly. With repeated reactivations, as contingencies become consolidated, less MTL activity is predicted. Finally, MTL bridging may aid processing transient but structured perceptual events, by allowing communication between upper and lower levels without calling on intermediate levels of representation. PMID:25426036

Medial temporal lobe-dependent repetition suppression and enhancement due to implicit vs. explicit processing of individual repeated search displays

PubMed Central

Geyer, Thomas; Baumgartner, Florian; Müller, Hermann J.; Pollmann, Stefan

2012-01-01

Using visual search, functional magnetic resonance imaging (fMRI) and patient studies have demonstrated that medial temporal lobe (MTL) structures differentiate repeated from novel displays—even when observers are unaware of display repetitions. This suggests a role for MTL in both explicit and, importantly, implicit learning of repeated sensory information (Greene et al., 2007). However, recent behavioral studies suggest, by examining visual search and recognition performance concurrently, that observers have explicit knowledge of at least some of the repeated displays (Geyer et al., 2010). The aim of the present fMRI study was thus to contribute new evidence regarding the contribution of MTL structures to explicit vs. implicit learning in visual search. It was found that MTL activation was increased for explicit and, respectively, decreased for implicit relative to baseline displays. These activation differences were most pronounced in left anterior parahippocampal cortex (aPHC), especially when observers were highly trained on the repeated displays. The data are taken to suggest that explicit and implicit memory processes are linked within MTL structures, but expressed via functionally separable mechanisms (repetition-enhancement vs. -suppression). They further show that repetition effects in visual search would have to be investigated at the display level. PMID:23060776

Hippocampal Networks Habituate as Novelty Accumulates

ERIC Educational Resources Information Center

Murty, Vishnu P.; Ballard, Ian C.; Macduffie, Katherine E.; Krebs, Ruth M.; Adcock, R. Alison

2013-01-01

Novelty detection, a critical computation within the medial temporal lobe (MTL) memory system, necessarily depends on prior experience. The current study used functional magnetic resonance imaging (fMRI) in humans to investigate dynamic changes in MTL activation and functional connectivity as experience with novelty accumulates. fMRI data were…

Functional Characterization of the Mannitol Promoter of Pseudomonas fluorescens DSM 50106 and Its Application for a Mannitol-Inducible Expression System for Pseudomonas putida KT2440

PubMed Central

Hoffmann, Jana; Altenbuchner, Josef

2015-01-01

A new pBBR1MCS-2-derived vector containing the Pseudomonas fluorescens DSM10506 mannitol promoter PmtlE and mtlR encoding its AraC/XylS type transcriptional activator was constructed and optimized for low basal expression. Mannitol, arabitol, and glucitol-inducible gene expression was demonstrated with Pseudomonas putida and eGFP as reporter gene. The new vector was applied for functional characterization of PmtlE. Identification of the DNA binding site of MtlR was achieved by in vivo eGFP measurement with PmtlE wild type and mutants thereof. Moreover, purified MtlR was applied for detailed in vitro investigations using electrophoretic mobility shift assays and DNaseI footprinting experiments. The obtained data suggest that MtlR binds to PmtlE as a dimer. The proposed DNA binding site of MtlR is AGTGC-N5-AGTAT-N7-AGTGC-N5-AGGAT. The transcription activation mechanism includes two binding sites with different binding affinities, a strong upstream binding site and a weaker downstream binding site. The presence of the weak downstream binding site was shown to be necessary to sustain mannitol-inducibility of PmtlE. Two possible functions of mannitol are discussed; the effector might stabilize binding of the second monomer to the downstream half site or promote transcription activation by inducing a conformational change of the regulator that influences the contact to the RNA polymerase. PMID:26207762

Mutations affecting transport of the hexitols D-mannitol, D-glucitol, and galactitol in Escherichia coli K-12: isolation and mapping.

PubMed Central

Lengeler, J

1975-01-01

Mutants of Escherichia coli K-12 unable to grow on any of the three naturally occurring hexitols D-manitol, D-glucitol, and galactitol and, among these specifically, mutants with altered transport and phosphorylating activity have been isolated. Different isolation procedures have been utilized, including suicide by D-[3H]mannitol, chemotaxis, and resistance to the toxic hexitol analogue 2-deoxy-arabino-hexitol. Mutations thus obtained have been mapped in four distinct operons. (i) Mutations affecting an enzyme II-complexmt1 activity of the phosphoenolpyruvate-dependent phosphotransferase system all map in gene mtlA. This gene has previously been shown (Solomon and Lin, 1972) to be part of an operon, mtl, located at 71 min on the E. coli linkage map containing, in addition to mtlA, the cis-dominant regulatory gene mtlC and mtlD, the structural gene for the enzyme D-mannitol-1-phosphate dehydrogenase. The gene order in this operon, induced by D-mannitol, is mtlC A D. (ii) Mutations in gene gutA affecting a second enzyme II-complexgut of the phosphotransferase system map at 51 min, clustered in operon gutC A D together with the cis-dominant regulatory gene gutC and the structural gene gutD for the enzyme D-glucitol-6-phosphate dehydrogenase. The gut operon, previously called sbl or srl, is induced by D-glucitol. (iii) Mutations affecting the transport and catabolism of galactitol are clustered in a third operon, gatC A D, located at 40.5 min. This operon again contains a cis-dominant regulatory gene, gatC, the structural gene gatD for galactitol-1-phosphate dehydrogenase, and gene gatA coding for a thrid hexitol-specific enzyme II-complexgat. Other genes coding for two additional enzymes involved in galactitol catabolism apparently are not linked to gatC A D. (iv) A fourth class of mutants pleiotropically negative for hexitol growth and transport maps in the pts operon. Triple-negative mutants (mtlA gutA gatA) do not have further transport or phosphorylating activity for any of the three hexitols. PMID:1100602

Arabitol Metabolism of Corynebacterium glutamicum and Its Regulation by AtlR

PubMed Central

Laslo, Tanja; von Zaluskowski, Philipp; Gabris, Christina; Lodd, Elisabeth; Rückert, Christian; Dangel, Petra; Kalinowski, Jörn; Auchter, Marc; Seibold, Gerd

2012-01-01

Expression profiling of Corynebacterium glutamicum in comparison to a derivative deficient in the transcriptional regulator AtlR (previously known as SucR or MtlR) revealed eight genes showing more than 4-fold higher mRNA levels in the mutant. Four of these genes are located in the direct vicinity of the atlR gene, i.e., xylB, rbtT, mtlD, and sixA, annotated as encoding xylulokinase, the ribitol transporter, mannitol 2-dehydrogenase, and phosphohistidine phosphatase, respectively. Transcriptional analysis indicated that atlR and the four genes are organized as atlR-xylB and rbtT-mtlD-sixA operons. Growth experiments with C. glutamicum and C. glutamicum ΔatlR, ΔxylB, ΔrbtT, ΔmtlD, and ΔsixA derivatives with sugar alcohols revealed that (i) wild-type C. glutamicum grows on d-arabitol but not on other sugar alcohols, (ii) growth in the presence of d-arabitol allows subsequent growth on d-mannitol, (iii) d-arabitol is cometabolized with glucose and preferentially utilized over d-mannitol, (iv) RbtT and XylB are involved in d-arabitol but not in d-mannitol metabolism, (v) MtlD is required for d-arabitol and d-mannitol metabolism, and (vi) SixA is not required for growth on any of the substrates tested. Furthermore, we show that MtlD confers d-arabitol and d-mannitol dehydrogenase activities, that the levels of these and also xylulokinase activities are generally high in the C. glutamicum ΔatlR mutant, whereas in the parental strain, they were high when cells were grown in the presence of d-arabitol and very low when cells were grown in its absence. Our results show that the XylB, RbtT, and MtlD proteins allow the growth of C. glutamicum on d-arabitol and that d-arabitol metabolism is subject to arabitol-dependent derepression by AtlR. PMID:22178972

Contributions of primate prefrontal cortex and medial temporal lobe to temporal-order memory.

PubMed

Naya, Yuji; Chen, He; Yang, Cen; Suzuki, Wendy A

2017-12-19

Neuropsychological and neurophysiological studies have emphasized the role of the prefrontal cortex (PFC) in maintaining information about the temporal order of events or items for upcoming actions. However, the medial temporal lobe (MTL) has also been considered critical to bind individual events or items to their temporal context in episodic memory. Here we characterize the contributions of these brain areas by comparing single-unit activity in the dorsal and ventral regions of macaque lateral PFC (d-PFC and v-PFC) with activity in MTL areas including the hippocampus (HPC), entorhinal cortex, and perirhinal cortex (PRC) as well as in area TE during the encoding phase of a temporal-order memory task. The v-PFC cells signaled specific items at particular time periods of the task. By contrast, MTL cortical cells signaled specific items across multiple time periods and discriminated the items between time periods by modulating their firing rates. Analysis of the temporal dynamics of these signals showed that the conjunctive signal of item and temporal-order information in PRC developed earlier than that seen in v-PFC. During the delay interval between the two cue stimuli, while v-PFC provided prominent stimulus-selective delay activity, MTL areas did not. Both regions of PFC and HPC exhibited an incremental timing signal that appeared to represent the continuous passage of time during the encoding phase. However, the incremental timing signal in HPC was more prominent than that observed in PFC. These results suggest that PFC and MTL contribute to the encoding of the integration of item and timing information in distinct ways.

Working memory, long-term memory, and medial temporal lobe function

PubMed Central

Jeneson, Annette; Squire, Larry R.

2012-01-01

Early studies of memory-impaired patients with medial temporal lobe (MTL) damage led to the view that the hippocampus and related MTL structures are involved in the formation of long-term memory and that immediate memory and working memory are independent of these structures. This traditional idea has recently been revisited. Impaired performance in patients with MTL lesions on tasks with short retention intervals, or no retention interval, and neuroimaging findings with similar tasks have been interpreted to mean that the MTL is sometimes needed for working memory and possibly even for visual perception itself. We present a reappraisal of this interpretation. Our main conclusion is that, if the material to be learned exceeds working memory capacity, if the material is difficult to rehearse, or if attention is diverted, performance depends on long-term memory even when the retention interval is brief. This fundamental notion is better captured by the terms subspan memory and supraspan memory than by the terms short-term memory and long-term memory. We propose methods for determining when performance on short-delay tasks must depend on long-term (supraspan) memory and suggest that MTL lesions impair performance only when immediate memory and working memory are insufficient to support performance. In neuroimaging studies, MTL activity during encoding is influenced by the memory load and correlates positively with long-term retention of the material that was presented. The most parsimonious and consistent interpretation of all the data is that subspan memoranda are supported by immediate memory and working memory and are independent of the MTL. PMID:22180053

Abnormal medial temporal activity for bound information during working memory maintenance in patients with schizophrenia.

PubMed

Luck, David; Danion, Jean-Marie; Marrer, Corrine; Pham, Bich-Tuy; Gounot, Daniel; Foucher, Jack

2010-08-01

Alterations of binding in long-term memory in schizophrenia are well established and occur as a result of aberrant activity in the medial temporal lobe (MTL). In working memory (WM), such a deficit is less clear and the pathophysiological bases remain unstudied. Seventeen patients with schizophrenia and 17 matched healthy controls performed a WM binding task while undergoing functional magnetic resonance imaging. Binding was assessed by contrasting two conditions comprising an equal amount of verbal and spatial information (i.e., three letters and three spatial locations), but differing in the absence or presence of a link between them. In healthy controls, MTL activation was observed for encoding and maintenance of bound information but not for its retrieval. Between-group comparisons revealed that patients with schizophrenia showed MTL hypoactivation during the maintenance phase only. In addition, BOLD signals correlated with behavioral performance in controls but not in patients with schizophrenia. Our results confirm the major role that the MTL plays in the pathophysiology of schizophrenia. Short-term and long-term relational memory deficits in schizophrenia may share common cognitive and functional pathological bases. Our results provide additional information about the episodic buffer that represents an integrative interface between WM and long-term memory. Copyright 2009 Wiley-Liss, Inc.

Role of Amygdala Connectivity in the Persistence of Emotional Memories Over Time: An Event-Related fMRI Investigation

PubMed Central

Dolcos, Florin; Cabeza, Roberto

2008-01-01

According to the consolidation hypothesis, enhanced memory for emotional information reflects the modulatory effect of the amygdala on the medial temporal lobe (MTL) memory system during consolidation. Although there is evidence that amygdala–MTL connectivity enhances memory for emotional stimuli, it remains unclear whether this enhancement increases over time, as consolidation processes unfold. To investigate this, we used functional magnetic resonance imaging to measure encoding activity predicting memory for emotionally negative and neutral pictures after short (20-min) versus long (1-week) delays. Memory measures distinguished between vivid remembering (recollection) and feelings of knowing (familiarity). Consistent with the consolidation hypothesis, the persistence of recollection over time (long divided by short) was greater for emotional than neutral pictures. Activity in the amygdala predicted subsequent memory to a greater extent for emotional than neutral pictures. Although this advantage did not vary with delay, the contribution of amygdala–MTL connectivity to subsequent memory for emotional items increased over time. Moreover, both this increase in connectivity and amygdala activity itself were correlated with individual differences in recollection persistence for emotional but not neutral pictures. These results suggest that the amygdala and its connectivity with the MTL are critical to sustaining emotional memories over time, consistent with the consolidation hypothesis. PMID:18375529

Development of MTL-CEBPA: Small Activating RNA Drug for Hepatocellular Carcinoma.

PubMed

Setten, Ryan L; Lightfoot, Helen L; Habib, Nagy A; Rossi, John J

2018-06-10

Oligonucleotide drug development has revolutionised the drug discovery field allowing the notoriously "undruggable" genome to potentially become "druggable". Within this field, 'small' or 'short' activating RNAs (saRNA) are a more recently discovered category of short double stranded RNA with clinical potential. SaRNAs promote endogenous transcription from target loci, a phenomenon widely observed in mammals known as RNA activation (RNAa). The ability to target a particular gene is dependent on the sequence of the saRNA. Hence, the potential clinical application of saRNA is to increase target gene expression in a sequence specific manner. SaRNA based oligonucleotide therapeutics present great promise in expanding the "druggable" genome with particular areas of interest including transcription factor activation and haploinsufficency. Review and Conclusion: In this mini-review, we describe the pre-clinical development of the first saRNA drug to enter the clinic. This saRNA, referred to as MTL-CEBPA, induces transcription of the transcription factor CCAAT/enhancer-binding protein alpha (CEBPα), a tumour suppressor and critical regulator of hepatocyte function. MTL-CEBPA is presently in Phase I clinical trials for hepatocellular carcinoma (HCC). The clinical development of MTL-CEBPA will demonstrate "proof of concept", showing that saRNAs can provide the basis for drugs which enhance targeted gene expression and consequently improve disease outcome in patients. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Neural activity in the hippocampus and perirhinal cortex during encoding is associated with the durability of episodic memory.

PubMed

Carr, Valerie A; Viskontas, Indre V; Engel, Stephen A; Knowlton, Barbara J

2010-11-01

Studies examining medial temporal lobe (MTL) involvement in memory formation typically assess memory performance after a single, short delay. Thus, the relationship between MTL encoding activity and memory durability over time remains poorly characterized. To explore this relationship, we scanned participants using high-resolution functional imaging of the MTL as they encoded object pairs; using the remember/know paradigm, we then assessed memory performance for studied items both 10 min and 1 week later. Encoding trials were classified as either subsequently recollected across both delays, transiently recollected (i.e., recollected at 10 min but not after 1 week), consistently familiar, or consistently forgotten. Activity in perirhinal cortex (PRC) and a hippocampal subfield comprising the dentate gyrus and CA fields 2 and 3 reflected successful encoding only when items were recollected consistently across both delays. Furthermore, in PRC, encoding activity for items that later were consistently recollected was significantly greater than that for transiently recollected and consistently familiar items. Parahippocampal cortex, in contrast, showed a subsequent memory effect during encoding of items that were recollected after 10 min, regardless of whether they also were recollected after 1 week. These data suggest that MTL subfields contribute uniquely to the formation of memories that endure over time, and highlight a role for PRC in supporting subsequent durable episodic recollection.

[Effect of manual acupuncture stimulation of "Zusanli" (ST 36) on gastric motility, and SP and motilin activities in gastric antrum and nucleus raphe magnus in gastric hyperactivity and hypoactivity rats].

PubMed

Yan, Chun-Chuan; Peng, Yan; Lin, Ya-Ping; Yi, Shou-Xiang; Chen, Ping; Hou, Yan-Ling; Shi, Dong-Mei

2013-10-01

To observe the changes of gastric motility and levels of substance P (SP) and motilin (MTL) in the gastric antrum and Nucleus Raphe Magnus (NRM) after manual acupuncture stimulation of "Zusanli" (ST 36) in gastric hyperactivity and hypoactivity rats, so as to analyze the role of NRM in acupuncture mediated adjustment of gastric motility. Fifty SD rats were randomly and equally divided into control, gastric hyperactivity (G-Hypera) model, gastric hypoactivity (G-Hypoa) model, acupuncture + G-Hypera and acupuncture + G-Hypoa groups (10 rats/group). G-Hypera model was established by intravenous (tail vein) injection of Maxolon (0.5 mL/200 g) and G-Hypoa model established by intravenous injection of Atropin (0.5 mL/200 g), respectively. After insertion of acupuncture needles into bilateral "Zusanli" (ST 36), the needles were repeatedly manipulated at a frequency of about 2 Hz for 5 min. The intragastric pressure was recorded and analyzed using a physiological signal analysis system. The SP and MTL contents of gastric antrum were measured by ELISA, and SP and MTL immunoactivity of NRM was determined by immunohistochemistry. In gastric hyperactivity rats, compared with the control group, the intragastric pressure (not systolic frequency), SP and MTL contents in the gastric antrum and MTL immunoactivity of NRM were significantly increased (P < 0.05, P < 0.01), while SP immunoactivity of NRM was apparently decreased in the G-Hypera model group (P < 0.01). After acupuncture stimulation, the intragastric pressure, gastric SP and MTL contents, and MTL immunoactivity of NRM were all significantly down-regulated (P < 0.05, P < 0.01), and SP immunoactivity of NRM was markedly up-regulated (P < 0.01) in comparison with the model group. In gastric hypoactivity rats, compared with the control group, the intragastric pressure and gastric systolic frequency, gastric SP and MTL contents, and MTL immunoactivity of NRM were significantly decreased (P < 0.05, PF < 0.01), while SP immunoactivity of NRM was remarkably up-regulated in the G-Hypoa model group (P < 0.01). After acupuncture stimulation, the above-mentioned 6 indexes were reversed significantly (P < 0.05, P < 0.01) in comparison with those of the model group. Acupuncture stimulation of "Zusanli" (ST 36) has an obvious bi-directional adjustment effect on gastric motility, which is closely associated with its functions in regulating gastric SP and MTL level and the expression of MTL and SP in the NRM of brainstem.

Neural correlates of incidental memory in mild cognitive impairment: an fMRI study.

PubMed

Mandzia, Jennifer L; McAndrews, Mary Pat; Grady, Cheryl L; Graham, Simon J; Black, Sandra E

2009-05-01

Behaviour and fMRI brain activation patterns were compared during encoding and recognition tasks in mild cognitive impairment (MCI) (n=14) and normal controls (NC) (n=14). Deep (natural vs. man-made) and shallow (color vs. black and white) decisions were made at encoding and pictures from each condition were presented for yes/no recognition 20 min later. MCI showed less inferior frontal activation during deep (left only) and superficial encoding (bilaterally) and in both medial temporal lobes (MTL). When performance was equivalent (recognition of words encoded superficially), MTL activation was similar for the two groups, but during recognition testing of deeply encoded items NC showed more activation in both prefrontal and left MTL region. In a region of interest analysis, the extent of activation during deep encoding in the parahippocampi bilaterally and in left hippocampus correlated with subsequent recognition accuracy for those items in controls but not in MCI, which may reflect the heterogeneity of activation responses in conjunction with different degrees of pathology burden and progression status in the MCI group.

Neural activity in the medial temporal lobe reveals the fidelity of mental time travel.

PubMed

Kragel, James E; Morton, Neal W; Polyn, Sean M

2015-02-18

Neural circuitry in the medial temporal lobe (MTL) is critically involved in mental time travel, which involves the vivid retrieval of the details of past experience. Neuroscientific theories propose that the MTL supports memory of the past by retrieving previously encoded episodic information, as well as by reactivating a temporal code specifying the position of a particular event within an episode. However, the neural computations supporting these abilities are underspecified. To test hypotheses regarding the computational mechanisms supported by different MTL subregions during mental time travel, we developed a computational model that linked a blood oxygenation level-dependent signal to cognitive operations, allowing us to predict human performance in a memory search task. Activity in the posterior MTL, including parahippocampal cortex, reflected how strongly one reactivates the temporal context of a retrieved memory, allowing the model to predict whether the next memory will correspond to a nearby moment in the study episode. A signal in the anterior MTL, including perirhinal cortex, indicated the successful retrieval of list items, without providing information regarding temporal organization. A hippocampal signal reflected both processes, consistent with theories that this region binds item and context information together to form episodic memories. These findings provide evidence for modern theories that describe complementary roles of the hippocampus and surrounding parahippocampal and perirhinal cortices during the retrieval of episodic memories, shaping how humans revisit the past. Copyright © 2015 the authors 0270-6474/15/352914-13$15.00/0.

The nature and time-course of medial temporal lobe contributions to semantic retrieval: an fMRI study on verbal fluency.

PubMed

Sheldon, Signy; Moscovitch, Morris

2012-06-01

Recent investigations have shown that the medial temporal lobe (MTL), a region thought to be exclusive to episodic memory, can also influence performance on tests of semantic memory. The present study examined further the nature of MTL contributions to semantic memory tasks by tracking MTL activation as participants performed category fluency, a traditional test of semantic retrieval. For categories that were inherently autobiographical (e.g. names of friends), the MTLs were activated throughout the time period in which items were generated, consistent with the MTLs role in retrieving autobiographical memories. For categories that could not benefit from autobiographical or spatial/context information (e.g. governmental offices), the MTL was not implicated at any time point. For categories for which both prototypical and episodically-related information exists (e.g. kitchen utensils), there was more robust MTL activity for the open-ended, late generation periods compared with the more well-defined, early item generation time periods. We interpret these results as suggesting that early in the generation phase, responses are based on well-rehearsed prototypical knowledge whereas later performance relies more on open-ended strategies, such as deriving exemplars from personally relevant contextual information (e.g. imagining one's own kitchen). These findings and interpretation were consistent with the results of an initial, separate behavioral study (Expt 1), that used the distinctiveness of responses as a measure of open-endedness across the generation phase: Response distinctiveness corresponded to the predicted open-endedness of the various tasks at early and late phases. Overall, this is consistent with the view that as generation of semantic information becomes open-ended, it recruits processes from other domains, such as episodic memory, to support performance. Copyright © 2011 Wiley Periodicals, Inc.

Cholinergic modulation of the CAN current may adjust neural dynamics for active memory maintenance, spatial navigation and time-compressed replay

PubMed Central

Yoshida, Motoharu; Knauer, Beate; Jochems, Arthur

2012-01-01

Suppression of cholinergic receptors and inactivation of the septum impair short-term memory, and disrupt place cell and grid cell activity in the medial temporal lobe (MTL). Location-dependent hippocampal place cell firing during active waking, when the acetylcholine level is high, switches to time-compressed replay activity during quiet waking and slow-wave-sleep (SWS), when the acetylcholine level is low. However, it remains largely unknown how acetylcholine supports short-term memory, spatial navigation, and the functional switch to replay mode in the MTL. In this paper, we focus on the role of the calcium-activated non-specific cationic (CAN) current which is activated by acetylcholine. The CAN current is known to underlie persistent firing, which could serve as a memory trace in many neurons in the MTL. Here, we review the CAN current and discuss possible roles of the CAN current in short-term memory and spatial navigation. We further propose a novel theoretical model where the CAN current switches the hippocampal place cell activity between real-time and time-compressed sequential activity during encoding and consolidation, respectively. PMID:22435051

The trophic fingerprint of marine fisheries.

PubMed

Branch, Trevor A; Watson, Reg; Fulton, Elizabeth A; Jennings, Simon; McGilliard, Carey R; Pablico, Grace T; Ricard, Daniel; Tracey, Sean R

2010-11-18

Biodiversity indicators provide a vital window on the state of the planet, guiding policy development and management. The most widely adopted marine indicator is mean trophic level (MTL) from catches, intended to detect shifts from high-trophic-level predators to low-trophic-level invertebrates and plankton-feeders. This indicator underpins reported trends in human impacts, declining when predators collapse ("fishing down marine food webs") and when low-trophic-level fisheries expand ("fishing through marine food webs"). The assumption is that catch MTL measures changes in ecosystem MTL and biodiversity. Here we combine model predictions with global assessments of MTL from catches, trawl surveys and fisheries stock assessments and find that catch MTL does not reliably predict changes in marine ecosystems. Instead, catch MTL trends often diverge from ecosystem MTL trends obtained from surveys and assessments. In contrast to previous findings of rapid declines in catch MTL, we observe recent increases in catch, survey and assessment MTL. However, catches from most trophic levels are rising, which can intensify fishery collapses even when MTL trends are stable or increasing. To detect fishing impacts on marine biodiversity, we recommend greater efforts to measure true abundance trends for marine species, especially those most vulnerable to fishing.

Dissociating retrieval success from incidental encoding activity during emotional memory retrieval, in the medial temporal lobe

PubMed Central

Shafer, Andrea T.; Dolcos, Florin

2014-01-01

The memory-enhancing effect of emotion has been linked to the engagement of emotion- and memory-related medial temporal lobe (MTL) regions (amygdala-AMY; hippocampus-HC; parahippocampus-PHC), during both encoding and retrieval. However, recognition tasks used to investigate the neural correlates of retrieval make it difficult to distinguish MTL engagement linked to retrieval success (RS) from that linked to incidental encoding success (ES) during retrieval. This issue has been investigated for retrieval of non-emotional memories, but not for emotional memory retrieval. To address this, we used event-related functional MRI in conjunction with an emotional distraction and two episodic memory tasks (one testing memory for distracter items and the other testing memory for new/lure items presented in the first memory task). This paradigm allowed for dissociation of MTL activity specifically linked to RS from that linked to both RS and incidental ES during retrieval. There were two novel findings regarding the neural correlates of emotional memory retrieval. First, greater emotional RS was identified bilaterally in AMY, HC, and PHC. However, AMY activity was most impacted when accounting for ES activity, as only RS activity in left AMY was dissociated from ES activity during retrieval, whereas portions of HC and PHC showing greater emotional RS were largely uninvolved in ES. Second, an earlier and more anteriorly spread response (left AMY and bilateral HC, PHC) was linked to greater emotional RS activity, whereas a later and more posteriorly localized response (right posterior PHC) was linked to greater neutral RS activity. These findings shed light on MTL mechanisms subserving the memory-enhancing effect of emotion at retrieval. PMID:24917798

The Mannitol Operon Repressor MTIR belongs to a new class of transcription regulators in bacteria.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tan, K.; Borovilos, M.; Zhou, M

2009-12-25

Many bacteria express phosphoenolpyruvate-dependent phosphotransferase systems (PTS). The mannitol-specific PTS catalyze the uptake and phosphorylation of d-mannitol. The uptake system comprises several genes encoded in the single operon. The expression of the mannitol operon is regulated by a proposed transcriptional factor, mannitol operon repressor (MtlR) that was first studied in Escherichia coli. Here we report the first crystal structures of MtlR from Vibrio parahemeolyticus (Vp-MtlR) and its homolog YggD protein from Shigella flexneri (Sf-YggD). MtlR and YggD belong to the same protein family (Pfam05068). Although Vp-MtlR and Sf-YggD share low sequence identity (22%), their overall structures are very similar, representingmore » a novel all {alpha}-helical fold, and indicate similar function. However, their lack of any known DNA-binding structural motifs and their unfavorable electrostatic properties imply that MtlR/YggD are unlikely to bind a specific DNA operator directly as proposed earlier. This structural observation is further corroborated by in vitro DNA-binding studies of E. coli MtlR (Ec-MtlR), which detected no interaction of Ec-MtlR with the well characterized mannitol operator/promoter region. Therefore, MtlR/YggD belongs to a new class of transcription factors in bacteria that may regulate gene expression indirectly as a part of a larger transcriptional complex.« less

Distinct and overlapping fMRI activation networks for processing of novel identities and locations of objects.

PubMed

Pihlajamäki, Maija; Tanila, Heikki; Könönen, Mervi; Hänninen, Tuomo; Aronen, Hannu J; Soininen, Hilkka

2005-10-01

The ventral visual stream processes information about the identity of objects ('what'), whereas the dorsal stream processes the spatial locations of objects ('where'). There is a corresponding, although disputed, distinction for the ventrolateral and dorsolateral prefrontal areas. Furthermore, there seems to be a distinction between the anterior and posterior medial temporal lobe (MTL) structures in the processing of novel items and new spatial arrangements, respectively. Functional differentiation of the intermediary mid-line cortical and temporal neocortical structures that communicate with the occipitotemporal, occipitoparietal, prefrontal, and MTL structures, however, is unclear. Therefore, in the present functional magnetic resonance imaging (fMRI) study, we examined whether the distinction among the MTL structures extends to these closely connected cortical areas. The most striking difference in the fMRI responses during visual presentation of changes in either items or their locations was the bilateral activation of the temporal lobe and ventrolateral prefrontal cortical areas for novel object identification in contrast to wide parietal and dorsolateral prefrontal activation for the novel locations of objects. An anterior-posterior distinction of fMRI responses similar to the MTL was observed in the cingulate/retrosplenial, and superior and middle temporal cortices. In addition to the distinct areas of activation, certain frontal, parietal, and temporo-occipital areas responded to both object and spatial novelty, suggesting a common attentional network for both types of changes in the visual environment. These findings offer new insights to the functional roles and intrinsic specialization of the cingulate/retrosplenial, and lateral temporal cortical areas in visuospatial cognition.

Metabolic engineering of mannitol production in Lactococcus lactis: influence of overexpression of mannitol 1-phosphate dehydrogenase in different genetic backgrounds.

PubMed

Wisselink, H Wouter; Mars, Astrid E; van der Meer, Pieter; Eggink, Gerrit; Hugenholtz, Jeroen

2004-07-01

To obtain a mannitol-producing Lactococcus lactis strain, the mannitol 1-phosphate dehydrogenase gene (mtlD) from Lactobacillus plantarum was overexpressed in a wild-type strain, a lactate dehydrogenase(LDH)-deficient strain, and a strain with reduced phosphofructokinase activity. High-performance liquid chromatography and (13)C nuclear magnetic resonance analysis revealed that small amounts (<1%) of mannitol were formed by growing cells of mtlD-overexpressing LDH-deficient and phosphofructokinase-reduced strains, whereas resting cells of the LDH-deficient transformant converted 25% of glucose into mannitol. Moreover, the formed mannitol was not reutilized upon glucose depletion. Of the metabolic-engineering strategies investigated in this work, mtlD-overexpressing LDH-deficient L. lactis seemed to be the most promising strain for mannitol production.

Flammability Characteristics of Fiber-Reinforced Composite Materials for the Composite Infantry Fighting Vehicle

DTIC Science & Technology

1990-09-01

Comments MTL-1 SZIPolyester 70/30 E-701 Baseline MTL-2 S2IPdyester’ 70130 Owens - Corning MTL-3 S2/Polyester* 70/30 American-Cyanamide MTL-5 S2IPhenolic...80120 Owens - Corning *Resin formulation is ro rietary t ~ e s i n is 50150 phenofc-FvB. ’ Organic polymers a re one of the major constituents of...SPECTROMETRY OF MTL-2, OWENS - CORNING ; 900°C IN HELIUM Peak No. Identification Carbon Monoxide and Carbon Dioxide Formaldehyde Propene 1.2-Propadiene 1

Metalloproteins and phytochelatin synthase may confer protection against zinc oxide nanoparticle induced toxicity in Caenorhabditis elegans.

PubMed

Polak, Natasa; Read, Daniel S; Jurkschat, Kerstin; Matzke, Marianne; Kelly, Frank J; Spurgeon, David J; Stürzenbaum, Stephen R

2014-03-01

Zinc oxide nanoparticles (ZnONPs) are used in large quantities by the cosmetic, food and textile industries. Here we exposed Caenorhabditis elegans wild-type and a metal sensitive triple knockout mutant (mtl-1;mtl-2;pcs-1) to ZnONPs (0-50mg/L) to study strain and exposure specific effects on transcription, reactive oxygen species generation, the biomolecular phenotype (measured by Raman microspectroscopy) and key endpoints of the nematode life cycle (growth, reproduction and lifespan). A significant dissolution effect was observed, where dissolved ZnO constituted over 50% of total Zn within a two day exposure to the test medium, suggesting that the nominal exposure to pure ZnONPs represents in vivo, at best, a mixture exposure of ionic zinc and nanoparticles. Nevertheless, the analyses provided evidence that the metallothioneins (mtl-1 and mtl-2), the phytochelatin synthase (pcs-1) and an apoptotic marker (cep-1) were transcriptionally activated. In addition, the DCFH-DA assay provided in vitro evidence of the oxidative potential of ZnONPs in the metal exposure sensitive triple mutant. Raman spectroscopy highlighted that the biomolecular phenotype changes significantly in the mtl-1;mtl-2;pcs-1 triple knockout worm upon ZnONP exposure, suggesting that these metalloproteins are instrumental in the protection against cytotoxic damage. Finally, ZnONP exposure was shown to decrease growth and development, reproductive capacity and lifespan, effects which were amplified in the triple knockout. By combining diverse toxicological strategies, we identified that individuals (genotypes) housing mutations in key metalloproteins and phytochelatin synthase are more susceptible to ZnONP exposure, which underlines their importance to minimize ZnONP induced toxicity. Copyright © 2013 Elsevier Inc. All rights reserved.

Stress as a mnemonic filter: Interactions between medial temporal lobe encoding processes and post-encoding stress

PubMed Central

Ritchey, Maureen; McCullough, Andrew M.; Ranganath, Charan; Yonelinas, Andrew P.

2016-01-01

Acute stress has been shown to modulate memory for recently learned information, an effect attributed to the influence of stress hormones on medial temporal lobe (MTL) consolidation processes. However, little is known about which memories will be affected when stress follows encoding. One possibility is that stress interacts with encoding processes to selectively protect memories that had elicited responses in the hippocampus and amygdala, two MTL structures important for memory formation. There is limited evidence for interactions between encoding processes and consolidation effects in humans, but recent studies of consolidation in rodents have emphasized the importance of encoding “tags” for determining the impact of consolidation manipulations on memory. Here, we used fMRI in humans to test the hypothesis that the effects of post-encoding stress depend on MTL processes observed during encoding. We found that changes in stress hormone levels were associated with an increase in the contingency of memory outcomes on hippocampal and amygdala encoding responses. That is, for participants showing high cortisol reactivity, memories became more dependent on MTL activity observed during encoding, thereby shifting the distribution of recollected events toward those that had elicited relatively high activation. Surprisingly, this effect was generally larger for neutral, compared to emotionally negative, memories. The results suggest that stress does not uniformly enhance memory, but instead selectively preserves memories tagged during encoding, effectively acting as mnemonic filter. PMID:27774683

The retrosplenial cortex: A memory gateway between the cortical default mode network and the medial temporal lobe.

PubMed

Kaboodvand, Neda; Bäckman, Lars; Nyberg, Lars; Salami, Alireza

2018-05-01

The default mode network (DMN) involves interacting cortical areas, including the posterior cingulate cortex (PCC) and the retrosplenial cortex (RSC), and subcortical areas, including the medial temporal lobe (MTL). The degree of functional connectivity (FC) within the DMN, particularly between MTL and medial-parietal subsystems, relates to episodic memory (EM) processes. However, past resting-state studies investigating the link between posterior DMN-MTL FC and EM performance yielded inconsistent results, possibly reflecting heterogeneity in the degree of connectivity between MTL and specific cortical DMN regions. Animal work suggests that RSC has structural connections to both cortical DMN regions and MTL, and may thus serve as an intermediate layer that facilitates information transfer between cortical and subcortical DMNs. We studied 180 healthy old adults (aged 64-68 years), who underwent comprehensive assessment of EM, along with resting-state fMRI. We found greater FC between MTL and RSC than between MTL and the other cortical DMN regions (e.g., PCC), with the only significant association with EM observed for MTL-RSC FC. Mediational analysis showed that MTL-cortical DMN connectivity increased with RSC as a mediator. Further analysis using a graph-theoretical approach on DMN nodes revealed the highest betweenness centrality for RSC, confirming that a high proportion of short paths among DMN regions pass through RSC. Importantly, the degree of RSC mediation was associated with EM performance, suggesting that individuals with greater mediation have an EM advantage. These findings suggest that RSC forms a critical gateway between MTL and cortical DMN to support EM in older adults. © 2018 Wiley Periodicals, Inc.

Medial Temporal Lobe Damage Causes Deficits in Episodic Memory and Episodic Future Thinking Not Attributable to Deficits in Narrative Construction

PubMed Central

Race, Elizabeth; Keane, Margaret M.; Verfaellie, Mieke

2015-01-01

The medial temporal lobe (MTL) makes critical contributions to episodic memory, but its contributions to episodic future thinking remain a matter of debate. By one view, imagining future events relies on MTL mechanisms that also support memory for past events. Alternatively, it has recently been suggested that future thinking is independent of MTL-mediated processes and can be supported by regions outside the MTL. The current study investigated the nature and necessity of MTL involvement in imagining the future and tested the novel hypothesis that the MTL contributes to future thinking by supporting online binding processes related to narrative construction. Human amnesic patients with well-characterized MTL damage and healthy controls constructed narratives about (a) future events, (b) past events, and (c) visually-presented pictures. While all three tasks place similar demands on narrative construction, only the past and future conditions require memory/future thinking to mentally generate relevant narrative information. Patients produced impoverished descriptions of both past and future events but were unimpaired at producing detailed picture narratives. In addition, future-thinking performance positively correlated with episodic memory performance but did not correlate with picture narrative performance. Finally, future-thinking impairments were present when MTL lesions were restricted to the hippocampus and did not depend on the presence of neural damage outside the MTL. These results indicate that the ability to generate and maintain a detailed narrative is preserved in amnesia and suggest that a common MTL mechanism supports both episodic memory and episodic future thinking. PMID:21753003

Medial temporal lobe damage causes deficits in episodic memory and episodic future thinking not attributable to deficits in narrative construction.

PubMed

Race, Elizabeth; Keane, Margaret M; Verfaellie, Mieke

2011-07-13

The medial temporal lobe (MTL) makes critical contributions to episodic memory, but its contributions to episodic future thinking remain a matter of debate. By one view, imagining future events relies on MTL mechanisms that also support memory for past events. Alternatively, it has recently been suggested that future thinking is independent of MTL-mediated processes and can be supported by regions outside the MTL. The current study investigated the nature and necessity of MTL involvement in imagining the future and tested the novel hypothesis that the MTL contributes to future thinking by supporting online binding processes related to narrative construction. Human amnesic patients with well characterized MTL damage and healthy controls constructed narratives about (1) future events, (2) past events, and (3) visually presented pictures. While all three tasks place similar demands on narrative construction, only the past and future conditions require memory/future thinking to mentally generate relevant narrative information. Patients produced impoverished descriptions of both past and future events but were unimpaired at producing detailed picture narratives. In addition, future-thinking performance positively correlated with episodic memory performance but did not correlate with picture narrative performance. Finally, future-thinking impairments were present when MTL lesions were restricted to the hippocampus and did not depend on the presence of neural damage outside the MTL. These results indicate that the ability to generate and maintain a detailed narrative is preserved in amnesia and suggest that a common MTL mechanism supports both episodic memory and episodic future thinking.

Method and apparatus for magnetic resonance imaging and spectroscopy using microstrip transmission line coils

DOEpatents

Zhang, Xiaoliang; Ugurbil, Kamil; Chen, Wei

2006-04-04

Apparatus and method for MRI imaging using a coil constructed of microstrip transmission line (MTL coil) are disclosed. In one method, a target is positioned to be imaged within the field of a main magnetic field of a magnet resonance imaging (MRI) system, a MTL coil is positioned proximate the target, and a MRI image is obtained using the main magnet and the MTL coil. In another embodiment, the MRI coil is used for spectroscopy. MRI imaging and spectroscopy coils are formed using microstrip transmission line. These MTL coils have the advantageous property of good performance while occupying a relatively small space, thus allowing MTL coils to be used inside restricted areas more easily than some other prior art coils. In addition, the MTL coils are relatively simple to construct of inexpensive components and thus relatively inexpensive compared to other designs. Further, the MTL coils of the present invention can be readily formed in a wide variety of coil configurations, and used in a wide variety of ways. Further, while the MTL coils of the present invention work well at high field strengths and frequencies, they also work at low frequencies and in low field strengths as well.

Tau and β-Amyloid Are Associated with Medial Temporal Lobe Structure, Function, and Memory Encoding in Normal Aging

PubMed Central

2017-01-01

Normal aging is associated with a decline in episodic memory and also with aggregation of the β-amyloid (Aβ) and tau proteins and atrophy of medial temporal lobe (MTL) structures crucial to memory formation. Although some evidence suggests that Aβ is associated with aberrant neural activity, the relationships among these two aggregated proteins, neural function, and brain structure are poorly understood. Using in vivo human Aβ and tau imaging, we demonstrate that increased Aβ and tau are both associated with aberrant fMRI activity in the MTL during memory encoding in cognitively normal older adults. This pathological neural activity was in turn associated with worse memory performance and atrophy within the MTL. A mediation analysis revealed that the relationship with regional atrophy was explained by MTL tau. These findings broaden the concept of cognitive aging to include evidence of Alzheimer's disease-related protein aggregation as an underlying mechanism of age-related memory impairment. SIGNIFICANCE STATEMENT Alterations in episodic memory and the accumulation of Alzheimer's pathology are common in cognitively normal older adults. However, evidence of pathological effects on episodic memory has largely been limited to β-amyloid (Aβ). Because Aβ and tau often cooccur in older adults, previous research offers an incomplete understanding of the relationship between pathology and episodic memory. With the recent development of in vivo tau PET radiotracers, we show that Aβ and tau are associated with different aspects of memory encoding, leading to aberrant neural activity that is behaviorally detrimental. In addition, our results provide evidence linking Aβ- and tau-associated neural dysfunction to brain atrophy. PMID:28213439

Reduced hippocampal activation during episodic encoding in middle-aged individuals at genetic risk of Alzheimer's Disease: a cross-sectional study

PubMed Central

Trivedi, Mehul A; Schmitz, Taylor W; Ries, Michele L; Torgerson, Britta M; Sager, Mark A; Hermann, Bruce P; Asthana, Sanjay; Johnson, Sterling C

2006-01-01

Background The presence of the apolipoprotein E (APOE) ε4 allele is a major risk factor for the development of Alzheimer's disease (AD), and has been associated with metabolic brain changes several years before the onset of typical AD symptoms. Functional MRI (fMRI) is a brain imaging technique that has been used to demonstrate hippocampal activation during measurement of episodic encoding, but the effect of the ε4 allele on hippocampal activation has not been firmly established. Methods The present study examined the effects of APOE genotype on brain activation patterns in the medial temporal lobe (MTL) during an episodic encoding task using a well-characterized novel item versus familiar item contrast in cognitively normal, middle-aged (mean = 54 years) individuals who had at least one parent with AD. Results We found that ε3/4 heterozygotes displayed reduced activation in the hippocampus and MTL compared to ε3/3 homozygotes. There were no significant differences between the groups in age, education or neuropsychological functioning, suggesting that the altered brain activation seen in ε3/4 heterozygotes was not associated with impaired cognitive function. We also found that participants' ability to encode information on a neuropsychological measure of learning was associated with greater activation in the anterior MTL in the ε3/3 homozygotes, but not in the ε3/4 heterozygotes. Conclusion Together with previous studies reporting reduced glucose metabolism and AD-related neuropathology, this study provides convergent validity for the idea that the MTL exhibits functional decline associated with the APOE ε4 allele. Importantly, these changes were detected in the absence of meaningful neuropsychological differences between the groups. A focus of ongoing work in this laboratory is to determine if these findings are predictive of subsequent cognitive decline. PMID:16412236

Short-Term Memory Depends on Dissociable Medial Temporal Lobe Regions in Amnestic Mild Cognitive Impairment

PubMed Central

Das, Sandhitsu R.; Mancuso, Lauren; Olson, Ingrid R.; Arnold, Steven E.; Wolk, David A.

2016-01-01

Short-term memory (STM) has generally been thought to be independent of the medial temporal lobe (MTL) in contrast to long-term memory (LTM). Prodromal Alzheimer's disease (AD) is a condition in which the MTL is a major early focus of pathology and LTM is thought disproportionately affected relative to STM. However, recent studies have suggested a role for the MTL in STM, particularly hippocampus, when binding of different elements is required. Other work has suggested involvement of extrahippocampal MTL structures, particularly in STM tasks that involve item-level memory. We examined STM for individual objects, locations, and object-location conjunctions in amnestic mild cognitive impairment (MCI), often associated with prodromal AD. Relative to age-matched, cognitively normal controls, MCI patients not only displayed impairment on object-location conjunctions but were similarly impaired for non-bound objects and locations. Moreover, across all participants, these conditions displayed dissociable correlations of cortical thinning along the long axis of the MTL and associated cortical nodes of anterior and posterior MTL networks. These findings support the role of the MTL in visual STM tasks and the division of labor of MTL in support of different types of memory representations, overlapping with findings in LTM. PMID:25725042

Individual differences in associative memory among older adults explained by hippocampal subfield structure and function.

PubMed

Carr, Valerie A; Bernstein, Jeffrey D; Favila, Serra E; Rutt, Brian K; Kerchner, Geoffrey A; Wagner, Anthony D

2017-11-07

Older adults experience impairments in episodic memory, ranging from mild to clinically significant. Given the critical role of the medial temporal lobe (MTL) in episodic memory, age-related changes in MTL structure and function may partially account for individual differences in memory. Using ultra-high-field 7T structural MRI and high-resolution 3T functional MRI (hr-fMRI), we evaluated MTL subfield thickness and function in older adults representing a spectrum of cognitive health. Participants performed an associative memory task during hr-fMRI in which they encoded and later retrieved face-name pairs. Motivated by prior research, we hypothesized that differences in performance would be explained by the following: ( i ) entorhinal cortex (ERC) and CA1 apical neuropil layer [CA1-stratum radiatum lacunosum moleculare (SRLM)] thickness, and ( ii ) activity in ERC and the dentate gyrus (DG)/CA3 region. Regression analyses revealed that this combination of factors significantly accounted for variability in memory performance. Among these metrics, CA1-SRLM thickness was positively associated with memory, whereas DG/CA3 retrieval activity was negatively associated with memory. Furthermore, including structural and functional metrics in the same model better accounted for performance than did single-modality models. These results advance the understanding of how independent but converging influences of both MTL subfield structure and function contribute to age-related memory impairment, complementing findings in the rodent and human postmortem literatures.

Rapid Encoding of New Memories by Individual Neurons in the Human Brain

PubMed Central

Ison, Matias J.; Quian Quiroga, Rodrigo; Fried, Itzhak

2015-01-01

Summary The creation of memories about real-life episodes requires rapid neuronal changes that may appear after a single occurrence of an event. How is such demand met by neurons in the medial temporal lobe (MTL), which plays a fundamental role in episodic memory formation? We recorded the activity of MTL neurons in neurosurgical patients while they learned new associations. Pairs of unrelated pictures, one of a person and another of a place, were used to construct a meaningful association modeling the episodic memory of meeting a person in a particular place. We found that a large proportion of responsive MTL neurons expanded their selectivity to encode these specific associations within a few trials: cells initially responsive to one picture started firing to the associated one but not to others. Our results provide a plausible neural substrate for the inception of associations, which are crucial for the formation of episodic memories. PMID:26139375

Short-Term Memory Depends on Dissociable Medial Temporal Lobe Regions in Amnestic Mild Cognitive Impairment.

PubMed

Das, Sandhitsu R; Mancuso, Lauren; Olson, Ingrid R; Arnold, Steven E; Wolk, David A

2016-05-01

Short-term memory (STM) has generally been thought to be independent of the medial temporal lobe (MTL) in contrast to long-term memory (LTM). Prodromal Alzheimer's disease (AD) is a condition in which the MTL is a major early focus of pathology and LTM is thought disproportionately affected relative to STM. However, recent studies have suggested a role for the MTL in STM, particularly hippocampus, when binding of different elements is required. Other work has suggested involvement of extrahippocampal MTL structures, particularly in STM tasks that involve item-level memory. We examined STM for individual objects, locations, and object-location conjunctions in amnestic mild cognitive impairment (MCI), often associated with prodromal AD. Relative to age-matched, cognitively normal controls, MCI patients not only displayed impairment on object-location conjunctions but were similarly impaired for non-bound objects and locations. Moreover, across all participants, these conditions displayed dissociable correlations of cortical thinning along the long axis of the MTL and associated cortical nodes of anterior and posterior MTL networks. These findings support the role of the MTL in visual STM tasks and the division of labor of MTL in support of different types of memory representations, overlapping with findings in LTM. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

I know I've seen you before: Distinguishing recent-single-exposure-based familiarity from pre-existing familiarity

PubMed Central

Gimbel, Sarah I.; Brewer, James B.; Maril, Anat

2018-01-01

This study examines how individuals differentiate recent-single-exposure-based familiarity from pre-existing familiarity. If these are two distinct cognitive processes, are they supported by the same neural bases? This study examines how recent-single-exposure-based familiarity and multiple-previous-exposure-based familiarity are supported and represented in the brain using functional MRI. In a novel approach, we first behaviorally show that subjects can divide retrieval of items in pre-existing memory into judgments of recollection and familiarity. Then, using functional magnetic resonance imaging, we examine the differences in blood oxygen level dependent activity and regional connectivity during judgments of recent-single-exposure-based and pre-existing familiarity. Judgments of these two types of familiarity showed distinct regions of activation in a whole-brain analysis, in medial temporal lobe (MTL) substructures, and in MTL substructure functional-correlations with other brain regions. Specifically, within the MTL, perirhinal cortex showed increased activation during recent-single-exposure-based familiarity while parahippocampal cortex showed increased activation during judgments of pre-existing familiarity. We find that recent-single-exposure-based and pre-existing familiarity are represented as distinct neural processes in the brain; this is supported by differing patterns of brain activation and regional correlations. This spatially distinct regional brain involvement suggests that the two separate experiences of familiarity, recent-exposure-based familiarity and pre-existing familiarity, may be cognitively distinct. PMID:28073651

Medial temporal lobe contributions to short-term memory for faces

PubMed Central

Race, Elizabeth; LaRocque, Karen F.; Keane, Margaret M.; Verfaellie, Mieke

2015-01-01

The role of the medial temporal lobes (MTL) in short-term memory (STM) remains a matter of debate. While imaging studies commonly show hippocampal activation during short-delay memory tasks, evidence from amnesic patients with MTL lesions is mixed. It has been argued that apparent STM impairments in amnesia may reflect long-term memory (LTM) contributions to performance. We challenge this conclusion by demonstrating that MTL amnesic patients show impaired delayed matching-to-sample (DMS) for faces in a task that meets both a traditional delay-based and a recently proposed distractor-based criterion for classification as a STM task. In Experiment 1, we demonstrate that our face DMS task meets the proposed distractor-based criterion for STM classification, in that extensive processing of delay-period distractor stimuli disrupts performance of healthy individuals. In Experiment 2, MTL amnesic patients with lesions extending into anterior subhippocampal cortex, but not patients with lesions limited to the hippocampus, show impaired performance on this task without distraction at delays as short as 8s, within temporal range of delay-based STM classification, in the context of intact perceptual matching performance. Experiment 3 provides support for the hypothesis that STM for faces relies on configural processing by showing that the extent to which healthy participants’ performance is disrupted by interference depends on the configural demands of the distractor task. Together, these findings are consistent with the notion that the amnesic impairment in STM for faces reflects a deficit in configural processing associated with subhippocampal cortices and provide novel evidence that the MTL supports cognition beyond the LTM domain. PMID:23937185

Electrical Stimulation in Hippocampus and Entorhinal Cortex Impairs Spatial and Temporal Memory.

PubMed

Goyal, Abhinav; Miller, Jonathan; Watrous, Andrew J; Lee, Sang Ah; Coffey, Tom; Sperling, Michael R; Sharan, Ashwini; Worrell, Gregory; Berry, Brent; Lega, Bradley; Jobst, Barbara C; Davis, Kathryn A; Inman, Cory; Sheth, Sameer A; Wanda, Paul A; Ezzyat, Youssef; Das, Sandhitsu R; Stein, Joel; Gorniak, Richard; Jacobs, Joshua

2018-05-09

The medial temporal lobe (MTL) is widely implicated in supporting episodic memory and navigation, but its precise functional role in organizing memory across time and space remains elusive. Here we examine the specific cognitive processes implemented by MTL structures (hippocampus and entorhinal cortex) to organize memory by using electrical brain stimulation, leveraging its ability to establish causal links between brain regions and features of behavior. We studied neurosurgical patients of both sexes who performed spatial-navigation and verbal-episodic memory tasks while brain stimulation was applied in various regions during learning. During the verbal memory task, stimulation in the MTL disrupted the temporal organization of encoded memories such that items learned with stimulation tended to be recalled in a more randomized order. During the spatial task, MTL stimulation impaired subjects' abilities to remember items located far away from boundaries. These stimulation effects were specific to the MTL. Our findings thus provide the first causal demonstration in humans of the specific memory processes that are performed by the MTL to encode when and where events occurred. SIGNIFICANCE STATEMENT Numerous studies have implicated the medial temporal lobe (MTL) in encoding spatial and temporal memories, but they have not been able to causally demonstrate the nature of the cognitive processes by which this occurs in real-time. Electrical brain stimulation is able to demonstrate causal links between a brain region and a given function with high temporal precision. By examining behavior in a memory task as subjects received MTL stimulation, we provide the first causal evidence demonstrating the role of the MTL in organizing the spatial and temporal aspects of episodic memory. Copyright © 2018 the authors 0270-6474/18/384471-11$15.00/0.

Stimulation of the human medial temporal lobe between learning and recall selectively enhances forgetting

PubMed Central

Merkow, Maxwell B.; Burke, John F.; Ramayya, Ashwin G.; Sharan, Ashwini D.; Sperling, Michael R.; Kahana, Michael J.

2017-01-01

Background Direct electrical stimulation applied to the human medial temporal lobe (MTL) typically disrupts performance on memory tasks, however, the mechanism underlying this effect is not known. Objective To study the effects of MTL stimulation on memory performance Methods We studied the effects of MTL stimulation on memory in five patients undergoing invasive electrocorticographic monitoring during various phases of a memory task (encoding, distractor, recall). Results We found that MTL stimulation disrupted memory performance in a timing-dependent manner; we observed greater forgetting when applying stimulation during the delay between encoding and recall, compared to when it was applied during encoding or recall. Conclusions The results suggest that recall is most dependent on the MTL between learning and retrieval. PMID:28073638

Neural Repetition Effects in the Medial Temporal Lobe Complex are Modulated by Previous Encoding Experience

PubMed Central

Greene, Ciara M.; Soto, David

2012-01-01

It remains an intriguing question why the medial temporal lobe (MTL) can display either attenuation or enhancement of neural activity following repetition of previously studied items. To isolate the role of encoding experience itself, we assessed neural repetition effects in the absence of any ongoing task demand or intentional orientation to retrieve. Experiment 1 showed that the hippocampus and surrounding MTL regions displayed neural repetition suppression (RS) upon repetition of past items that were merely attended during an earlier study phase but this was not the case following re-occurrence of items that had been encoded into working memory (WM). In this latter case a trend toward neural repetition enhancement (RE) was observed, though this was highly variable across individuals. Interestingly, participants with a higher degree of neural RE in the MTL complex displayed higher memory sensitivity in a later, surprise recognition test. Experiment 2 showed that massive exposure at encoding effected a change in the neural architecture supporting incidental repetition effects, with regions of the posterior parietal and ventral-frontal cortex in addition to the hippocampus displaying neural RE, while no neural RS was observed. The nature of encoding experience therefore modulates the expression of neural repetition effects in the MTL and the neocortex in the absence of memory goals. PMID:22829892

Prefrontal and medial temporal contributions to episodic memory-based reasoning.

PubMed

Suzuki, Chisato; Tsukiura, Takashi; Mochizuki-Kawai, Hiroko; Shigemune, Yayoi; Iijima, Toshio

2009-03-01

Episodic memory retrieval and reasoning are fundamental psychological components of our daily lives. Although previous studies have investigated the brain regions associated with these processes separately, the neural mechanisms of reasoning based on episodic memory retrieval are largely unknown. Here, we investigated the neural correlates underlying episodic memory-based reasoning using functional magnetic resonance imaging (fMRI). During fMRI scanning, subjects performed three tasks: reasoning, episodic memory retrieval, and episodic memory-based reasoning. We identified dissociable activations related to reasoning, episodic memory retrieval, and linking processes between the two. Regions related to reasoning were identified in the left ventral prefrontal cortices (PFC), and those related to episodic memory retrieval were found in the right medial temporal lobe (MTL) regions. In addition, activations predominant in the linking process between the two were found in the left dorsal and right ventral PFC. These findings suggest that episodic memory-based reasoning is composed of at least three processes, i.e., reasoning, episodic memory retrieval, and linking processes between the two, and that activation of both the PFC and MTL is crucial in episodic memory-based reasoning. These findings are the first to demonstrate that PFC and MTL regions contribute differentially to each process in episodic memory-based reasoning.

Contributions of Medial Temporal Lobe and Striatal Memory Systems to Learning and Retrieving Overlapping Spatial Memories

PubMed Central

Brown, Thackery I.; Stern, Chantal E.

2014-01-01

Many life experiences share information with other memories. In order to make decisions based on overlapping memories, we need to distinguish between experiences to determine the appropriate behavior for the current situation. Previous work suggests that the medial temporal lobe (MTL) and medial caudate interact to support the retrieval of overlapping navigational memories in different contexts. The present study used functional magnetic resonance imaging (fMRI) in humans to test the prediction that the MTL and medial caudate play complementary roles in learning novel mazes that cross paths with, and must be distinguished from, previously learned routes. During fMRI scanning, participants navigated virtual routes that were well learned from prior training while also learning new mazes. Critically, some routes learned during scanning shared hallways with those learned during pre-scan training. Overlap between mazes required participants to use contextual cues to select between alternative behaviors. Results demonstrated parahippocampal cortex activity specific for novel spatial cues that distinguish between overlapping routes. The hippocampus and medial caudate were active for learning overlapping spatial memories, and increased their activity for previously learned routes when they became context dependent. Our findings provide novel evidence that the MTL and medial caudate play complementary roles in the learning, updating, and execution of context-dependent navigational behaviors. PMID:23448868

Stimulation of the human medial temporal lobe between learning and recall selectively enhances forgetting.

PubMed

Merkow, Maxwell B; Burke, John F; Ramayya, Ashwin G; Sharan, Ashwini D; Sperling, Michael R; Kahana, Michael J

Direct electrical stimulation applied to the human medial temporal lobe (MTL) typically disrupts performance on memory tasks, however, the mechanism underlying this effect is not known. To study the effects of MTL stimulation on memory performance. We studied the effects of MTL stimulation on memory in five patients undergoing invasive electrocorticographic monitoring during various phases of a memory task (encoding, distractor, recall). We found that MTL stimulation disrupted memory performance in a timing-dependent manner; we observed greater forgetting when applying stimulation during the delay between encoding and recall, compared to when it was applied during encoding or recall. The results suggest that recall is most dependent on the MTL between learning and retrieval. Copyright © 2017 Elsevier Inc. All rights reserved.

Entorhinal Tau Pathology, Episodic Memory Decline, and Neurodegeneration in Aging.

PubMed

Maass, Anne; Lockhart, Samuel N; Harrison, Theresa M; Bell, Rachel K; Mellinger, Taylor; Swinnerton, Kaitlin; Baker, Suzanne L; Rabinovici, Gil D; Jagust, William J

2018-01-17

The medial temporal lobe (MTL) is an early site of tau accumulation and MTL dysfunction may underlie episodic-memory decline in aging and dementia. Postmortem data indicate that tau pathology in the transentorhinal cortex is common by age 60, whereas spread to neocortical regions and worsening of cognition is associated with β-amyloid (Aβ). We used [ 18 F]AV-1451 and [ 11 C]PiB positron emission tomography, structural MRI, and neuropsychological assessment to investigate how in vivo tau accumulation in temporal lobe regions, Aβ, and MTL atrophy contribute to episodic memory in cognitively normal older adults ( n = 83; age, 77 ± 6 years; 58% female). Stepwise regressions identified tau in MTL regions known to be affected in old age as the best predictor of episodic-memory performance independent of Aβ status. There was no interactive effect of MTL tau with Aβ on memory. Higher MTL tau was related to higher age in the subjects without evidence of Aβ. Among temporal lobe subregions, episodic memory was most strongly related to tau-tracer uptake in the parahippocampal gyrus, particularly the posterior entorhinal cortex, which in our parcellation includes the transentorhinal cortex. In subjects with longitudinal MRI and cognitive data ( n = 57), entorhinal atrophy mirrored patterns of tau pathology and their relationship with memory decline. Our data are consistent with neuropathological studies and further suggest that entorhinal tau pathology underlies memory decline in old age even without Aβ. SIGNIFICANCE STATEMENT Tau tangles and β-amyloid (Aβ) plaques are key lesions in Alzheimer's disease (AD) but both pathologies also occur in cognitively normal older people. Neuropathological data indicate that tau tangles in the medial temporal lobe (MTL) underlie episodic-memory impairments in AD dementia. However, it remains unclear whether MTL tau pathology also accounts for memory impairments often seen in elderly people and how Aβ affects this relationship. Using tau-specific and Aβ-specific positron emission tomography tracers, we show that in vivo MTL tau pathology is associated with episodic-memory performance and MTL atrophy in cognitively normal adults, independent of Aβ. Our data point to MTL tau pathology, particularly in the entorhinal cortex, as a substrate of age-related episodic-memory loss. Copyright © 2018 the authors 0270-6474/18/380530-14$15.00/0.

Mapping working memory retrieval in space and in time: A combined electroencephalography and electrocorticography approach.

PubMed

Zhang, Qiong; van Vugt, Marieke; Borst, Jelmer P; Anderson, John R

2018-07-01

In this study, we investigated the time course and neural correlates of the retrieval process underlying visual working memory. We made use of a rare dataset in which the same task was recorded using both scalp electroencephalography (EEG) and Electrocorticography (ECoG), respectively. This allowed us to examine with great spatial and temporal detail how the retrieval process works, and in particular how the medial temporal lobe (MTL) is involved. In each trial, participants judged whether a probe face had been among a set of recently studied faces. With a method that combines hidden semi-Markov models and multivariate pattern analysis, the neural signal was decomposed into a sequence of latent cognitive stages with information about their durations on a trial-by-trial basis. Analyzed separately, EEG and ECoG data yielded converging results on discovered stages and their interpretation, which reflected 1) a brief pre-attention stage, 2) encoding the stimulus, 3) retrieving the studied set, and 4) making a decision. Combining these stages with the high spatial resolution of ECoG suggested that activity in the temporal cortex reflected item familiarity in the retrieval stage; and that once retrieval is complete, there is active maintenance of the studied face set in the decision stage in the MTL. During this same period, the frontal cortex guides the decision by means of theta coupling with the MTL. These observations generalize previous findings on the role of MTL theta from long-term memory tasks to short-term memory tasks. Copyright © 2018 Elsevier Inc. All rights reserved.

The feeling of familiarity for music in patients with a unilateral temporal lobe lesion: A gating study.

PubMed

Huijgen, Josefien; Dellacherie, Delphine; Tillmann, Barbara; Clément, Sylvain; Bigand, Emmanuel; Dupont, Sophie; Samson, Séverine

2015-10-01

Previous research has indicated that the medial temporal lobe (MTL), and more specifically the perirhinal cortex, plays a role in the feeling of familiarity for non-musical stimuli. Here, we examined contribution of the MTL to the feeling of familiarity for music by testing patients with unilateral MTL lesions. We used a gating paradigm: segments of familiar and unfamiliar musical excerpts were played with increasing durations (250, 500, 1000, 2000, 4000 ms and complete excerpts), and participants provided familiarity judgments for each segment. Based on the hypothesis that patients might need longer segments than healthy controls (HC) to identify excerpts as familiar, we examined the onset of the emergence of familiarity in HC, patients with a right MTL resection (RTR), and patients with a left MTL resection (LTR). In contrast to our hypothesis, we found that the feeling of familiarity was relatively spared in patients with a right or left MTL lesion, even for short excerpts. All participants were able to differentiate familiar from unfamiliar excerpts as early as 500 ms, although the difference between familiar and unfamiliar judgements was greater in HC than in patients. These findings suggest that a unilateral MTL lesion does not impair the emergence of the feeling of familiarity. We also assessed whether the dynamics of the musical excerpt (linked to the type and amount of information contained in the excerpts) modulated the onset of the feeling of familiarity in the three groups. The difference between familiar and unfamiliar judgements was greater for high than for low-dynamic excerpts for HC and RTR patients, but not for LTR patients. This indicates that the LTR group did not benefit in the same way from dynamics. Overall, our results imply that the recognition of previously well-learned musical excerpts does not depend on the integrity of either right or the left MTL structures. Patients with a unilateral MTL resection may compensate for the effects of unilateral damage by using the intact contralateral temporal lobe. Moreover, we suggest that remote semantic memory for music might depend more strongly on neocortical structures rather than the MTL. Copyright © 2015. Published by Elsevier Ltd.

Material specific lateralization of medial temporal lobe function: An fMRI investigation.

PubMed

Dalton, Marshall A; Hornberger, Michael; Piguet, Olivier

2016-03-01

The theory of material specific lateralization of memory function posits that left and right MTL regions are asymmetrically involved in mnemonic processing of verbal and nonverbal material respectively. Lesion and functional imaging (fMRI) studies provide robust evidence for a left MTL asymmetry in the verbal memory domain. Evidence for a right MTL/nonverbal asymmetry is not as robust. A handful of fMRI studies have investigated this issue but have generally utilised nonverbal stimuli which are amenable to semantic elaboration. This fMRI study aimed to investigate the neural correlates of recognition memory processing in 20 healthy young adults (mean age = 26 years) for verbal stimuli and nonverbal stimuli that were specifically designed to minimize verbalisation. Analyses revealed that the neural correlates of recognition memory processing for verbal and nonverbal stimuli were differentiable and asymmetrically recruited the left and right MTL respectively. The right perirhinal cortex and hippocampus were preferentially involved in successful recognition memory of items devoid of semantic information. In contrast, the left anterior hippocampus was preferentially involved in successful recognition memory of stimuli which contained semantic meaning. These results suggest that the left MTL is preferentially involved in mnemonic processing of verbal/semantic information. In contrast, the right MTL is preferentially involved in visual/non-semantic mnemonic processing. We propose that during development, the left MTL becomes specialised for verbal mnemonic processing due to its proximity with left lateralised cortical language processing areas while visual/non-semantic mnemonic processing gets 'crowded out' to become predominantly, but not completely, the domain of the right MTL. © 2015 Wiley Periodicals, Inc.

Encoding of Target Detection during Visual Search by Single Neurons in the Human Brain.

PubMed

Wang, Shuo; Mamelak, Adam N; Adolphs, Ralph; Rutishauser, Ueli

2018-06-08

Neurons in the primate medial temporal lobe (MTL) respond selectively to visual categories such as faces, contributing to how the brain represents stimulus meaning. However, it remains unknown whether MTL neurons continue to encode stimulus meaning when it changes flexibly as a function of variable task demands imposed by goal-directed behavior. While classically associated with long-term memory, recent lesion and neuroimaging studies show that the MTL also contributes critically to the online guidance of goal-directed behaviors such as visual search. Do such tasks modulate responses of neurons in the MTL, and if so, do their responses mirror bottom-up input from visual cortices or do they reflect more abstract goal-directed properties? To answer these questions, we performed concurrent recordings of eye movements and single neurons in the MTL and medial frontal cortex (MFC) in human neurosurgical patients performing a memory-guided visual search task. We identified a distinct population of target-selective neurons in both the MTL and MFC whose response signaled whether the currently fixated stimulus was a target or distractor. This target-selective response was invariant to visual category and predicted whether a target was detected or missed behaviorally during a given fixation. The response latencies, relative to fixation onset, of MFC target-selective neurons preceded those in the MTL by ∼200 ms, suggesting a frontal origin for the target signal. The human MTL thus represents not only fixed stimulus identity, but also task-specified stimulus relevance due to top-down goal relevance. Copyright © 2018 Elsevier Ltd. All rights reserved.

Arousal Enhanced Memory Retention Is Eliminated Following Temporal Lobe Resection

ERIC Educational Resources Information Center

Ahs, Fredrik; Kumlien, Eva; Fredrikson, Mats

2010-01-01

The amygdala, situated in the anterior medial temporal lobe (MTL), is involved in the emotional enhancement of memory. The present study evaluated whether anterior MTL-resections attenuated arousal induced memory enhancement for pictures. Also, the effect of MTL-resections on response latencies at retrieval was assessed. Thirty-one patients with…

Medial temporal lobe contributions to short-term memory for faces.

PubMed

Race, Elizabeth; LaRocque, Karen F; Keane, Margaret M; Verfaellie, Mieke

2013-11-01

The role of the medial temporal lobes (MTL) in short-term memory (STM) remains a matter of debate. Whereas imaging studies commonly show hippocampal activation during short-delay memory tasks, evidence from amnesic patients with MTL lesions is mixed. It has been argued that apparent STM impairments in amnesia may reflect long-term memory (LTM) contributions to performance. We challenge this conclusion by demonstrating that MTL amnesic patients show impaired delayed matching-to-sample (DMS) for faces in a task that meets both a traditional delay-based and a recently proposed distractor-based criterion for classification as an STM task. In Experiment 1, we demonstrate that our face DMS task meets the proposed distractor-based criterion for STM classification, in that extensive processing of delay-period distractor stimuli disrupts performance of healthy individuals. In Experiment 2, MTL amnesic patients with lesions extending into anterior subhippocampal cortex, but not patients with lesions limited to the hippocampus, show impaired performance on this task without distraction at delays as short as 8 s, within temporal range of delay-based STM classification, in the context of intact perceptual matching performance. Experiment 3 provides support for the hypothesis that STM for faces relies on configural processing by showing that the extent to which healthy participants' performance is disrupted by interference depends on the configural demands of the distractor task. Together, these findings are consistent with the notion that the amnesic impairment in STM for faces reflects a deficit in configural processing associated with subhippocampal cortices and provide novel evidence that the MTL supports cognition beyond the LTM domain. PsycINFO Database Record (c) 2013 APA, all rights reserved.

I know I've seen you before: Distinguishing recent-single-exposure-based familiarity from pre-existing familiarity.

PubMed

Gimbel, Sarah I; Brewer, James B; Maril, Anat

2017-03-01

This study examines how individuals differentiate recent-single-exposure-based familiarity from pre-existing familiarity. If these are two distinct cognitive processes, are they supported by the same neural bases? This study examines how recent-single-exposure-based familiarity and multiple-previous-exposure-based familiarity are supported and represented in the brain using functional MRI. In a novel approach, we first behaviorally show that subjects can divide retrieval of items in pre-existing memory into judgments of recollection and familiarity. Then, using functional magnetic resonance imaging, we examine the differences in blood oxygen level dependent activity and regional connectivity during judgments of recent-single-exposure-based and pre-existing familiarity. Judgments of these two types of familiarity showed distinct regions of activation in a whole-brain analysis, in medial temporal lobe (MTL) substructures, and in MTL substructure functional-correlations with other brain regions. Specifically, within the MTL, perirhinal cortex showed increased activation during recent-single-exposure-based familiarity while parahippocampal cortex showed increased activation during judgments of pre-existing familiarity. We find that recent-single-exposure-based and pre-existing familiarity are represented as distinct neural processes in the brain; this is supported by differing patterns of brain activation and regional correlations. This spatially distinct regional brain involvement suggests that the two separate experiences of familiarity, recent-exposure-based familiarity and pre-existing familiarity, may be cognitively distinct. Copyright © 2017 Elsevier B.V. All rights reserved.

Process dissociation between contextual retrieval and item recognition.

PubMed

Weis, Susanne; Specht, Karsten; Klaver, Peter; Tendolkar, Indira; Willmes, Klaus; Ruhlmann, Jürgen; Elger, Christian E; Fernández, Guillén

2004-12-22

We employed a source memory task in an event related fMRI study to dissociate MTL processes associated with either contextual retrieval or item recognition. To introduce context during study, stimuli (photographs of buildings and natural landscapes) were transformed into one of four single-color-scales: red, blue, yellow, or green. In the subsequent old/new recognition memory test, all stimuli were presented as gray scale photographs, and old-responses were followed by a four-alternative source judgment referring to the color in which the stimulus was presented during study. Our results suggest a clear-cut process dissociation within the human MTL. While an activity increase accompanies successful retrieval of contextual information, an activity decrease provides a familiarity signal that is sufficient for successful item recognition.

Selective Familiarity Deficits after Left Anterior Temporal-Lobe Removal with Hippocampal Sparing Are Material Specific

ERIC Educational Resources Information Center

Martin, Chris B.; Bowles, Ben; Mirsattari, Seyed M.; Kohler, Stefan

2011-01-01

Research has firmly established a link between recognition memory and the functional integrity of the medial temporal lobes (MTL). Dual-process models of MTL organization maintain that there is a division of labour within the MTL, with the hippocampus (HC) supporting recollective processes and perirhinal cortex (PRc) supporting familiarity…

Enzyme II/sup Mtl/ of the Escherichia coli phosphoenolpyruvate-dependent phosphotransferase system: identification of the activity-linked cysteine on the mannitol carrier

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pas, H.H.; Robillard, G.T.

1988-07-26

The cysteine of the membrane-bound mannitol-specific enzyme II (EII/sup Mtl/) of the Escherichia coli phosphoenolpyruvate-dependent phosphotransferase system have been labeled with 4-vinylpyridine. After proteolytic breakdown and reversed-phase HPLC, the peptides containing cysteines 110, 384, and 571 could be identified. N-Ethylmaleimide (NEM) treatment of the native unphosphorylated enzyme results in incorporation of one NEM label per molecule and loss of enzymatic activity. NEM treatment and inactivation prevented 4-vinylpyridine incorporation into the Cys-384-containing peptide, identifying this residue as the activity-linked cysteine. Both oxidation and phosphorylation of the native enzyme protected the enzyme against NEM labeling of Cys-384. Positive identification of the activity-linkedmore » cysteine was accomplished by inactivation with (/sup 14/C)iodoacetamide, proteolytic fragmentation, isolation of the peptide, and amino acid sequencing.« less

Genetically Engineered Escherichia coli Nissle 1917 Synbiotics Reduce Metabolic Effects Induced by Chronic Consumption of Dietary Fructose

PubMed Central

Somabhai, Chaudhari Archana; Raghuvanshi, Ruma; Nareshkumar, G.

2016-01-01

Aims To assess protective efficacy of genetically modified Escherichia coli Nissle 1917 (EcN) on metabolic effects induced by chronic consumption of dietary fructose. Materials and Methods EcN was genetically modified with fructose dehydrogenase (fdh) gene for conversion of fructose to 5-keto-D-fructose and mannitol-2-dehydrogenase (mtlK) gene for conversion to mannitol, a prebiotic. Charles foster rats weighing 150–200 g were fed with 20% fructose in drinking water for two months. Probiotic treatment of EcN (pqq), EcN (pqq-glf-mtlK), EcN (pqq-fdh) was given once per week 109 cells for two months. Furthermore, blood and liver parameters for oxidative stress, dyslipidemia and hyperglycemia were estimated. Fecal samples were collected to determine the production of short chain fatty acids and pyrroloquinoline quinone (PQQ) production. Results EcN (pqq-glf-mtlK), EcN (pqq-fdh) transformants were confirmed by restriction digestion and functionality was checked by PQQ estimation and HPLC analysis. There was significant increase in body weight, serum glucose, liver injury markers, lipid profile in serum and liver, and decrease in antioxidant enzyme activity in high-fructose-fed rats. However the rats treated with EcN (pqq-glf-mtlK) and EcN (pqq-fdh) showed significant reduction in lipid peroxidation along with increase in serum and hepatic antioxidant enzyme activities. Restoration of liver injury marker enzymes was also seen. Increase in short chain fatty acids (SCFA) demonstrated the prebiotic effects of mannitol and gluconic acid. Conclusions Our study demonstrated the effectiveness of probiotic EcN producing PQQ and fructose metabolizing enzymes against the fructose induced hepatic steatosis suggesting that its potential for use in treating fructose induced metabolic syndrome. PMID:27760187

Concept cells through associative learning of high-level representations.

PubMed

Reddy, Leila; Thorpe, Simon J

2014-10-22

In this issue of Neuron, Quian Quiroga et al. (2014) show that neurons in the human medial temporal lobe (MTL) follow subjects' perceptual states rather than the features of the visual input. Patients with MTL damage however have intact perceptual abilities but suffer instead from extreme forgetfulness. Thus, the reported MTL neurons could create new memories of the current perceptual state.

Differences between mean tide level and mean sea level

NASA Astrophysics Data System (ADS)

Woodworth, P. L.

2017-01-01

This paper discusses the differences between mean tide level (MTL) and mean sea level (MSL) as demonstrated using information from a global tide gauge data set. The roles of the two main contributors to differences between MTL and MSL (the M4 harmonic of the M2 semidiurnal tide, and the combination of the diurnal tides K1 and O1) are described, with a particular focus on the spatial scales of variation in MTL-MSL due to each contributor. Findings from the tide gauge data set are contrasted with those from a state-of-the-art global tide model. The study is of interest within tidal science, but also has practical importance regarding the type of mean level used to define land survey datums. In addition, an appreciation of MTL-MSL difference is important in the use of the historical sea level data used in climate change research, with implications for some of the data stored in international databanks. Particular studies are made of how MTL and MSL might differ through the year, and if MTL is measured in daylight hours only, as has been the practice of some national geodetic agencies on occasions in the past.

Neural correlates of confidence during item recognition and source memory retrieval: evidence for both dual-process and strength memory theories.

PubMed

Hayes, Scott M; Buchler, Norbou; Stokes, Jared; Kragel, James; Cabeza, Roberto

2011-12-01

Although the medial-temporal lobes (MTL), PFC, and parietal cortex are considered primary nodes in the episodic memory network, there is much debate regarding the contributions of MTL, PFC, and parietal subregions to recollection versus familiarity (dual-process theory) and the feasibility of accounts on the basis of a single memory strength process (strength theory). To investigate these issues, the current fMRI study measured activity during retrieval of memories that differed quantitatively in terms of strength (high vs. low-confidence trials) and qualitatively in terms of recollection versus familiarity (source vs. item memory tasks). Support for each theory varied depending on which node of the episodic memory network was considered. Results from MTL best fit a dual-process account, as a dissociation was found between a right hippocampal region showing high-confidence activity during the source memory task and bilateral rhinal regions showing high-confidence activity during the item memory task. Within PFC, several left-lateralized regions showed greater activity for source than item memory, consistent with recollective orienting, whereas a right-lateralized ventrolateral area showed low-confidence activity in both tasks, consistent with monitoring processes. Parietal findings were generally consistent with strength theory, with dorsal areas showing low-confidence activity and ventral areas showing high-confidence activity in both tasks. This dissociation fits with an attentional account of parietal functions during episodic retrieval. The results suggest that both dual-process and strength theories are partly correct, highlighting the need for an integrated model that links to more general cognitive theories to account for observed neural activity during episodic memory retrieval.

Neural Correlates of Confidence during Item Recognition and Source Memory Retrieval: Evidence for Both Dual-process and Strength Memory Theories

PubMed Central

Hayes, Scott M.; Buchler, Norbou; Stokes, Jared; Kragel, James; Cabeza, Roberto

2012-01-01

Although the medial-temporal lobes (MTL), PFC, and parietal cortex are considered primary nodes in the episodic memory network, there is much debate regarding the contributions of MTL, PFC, and parietal subregions to recollection versus familiarity (dual-process theory) and the feasibility of accounts on the basis of a single memory strength process (strength theory). To investigate these issues, the current fMRI study measured activity during retrieval of memories that differed quantitatively in terms of strength (high vs. low-confidence trials) and qualitatively in terms of recollection versus familiarity (source vs. item memory tasks). Support for each theory varied depending on which node of the episodic memory network was considered. Results from MTL best fit a dual-process account, as a dissociation was found between a right hippocampal region showing high-confidence activity during the source memory task and bilateral rhinal regions showing high-confidence activity during the item memory task. Within PFC, several left-lateralized regions showed greater activity for source than item memory, consistent with recollective orienting, whereas a right-lateralized ventrolateral area showed low-confidence activity in both tasks, consistent with monitoring processes. Parietal findings were generally consistent with strength theory, with dorsal areas showing low-confidence activity and ventral areas showing high-confidence activity in both tasks. This dissociation fits with an attentional account of parietal functions during episodic retrieval. The results suggest that both dual-process and strength theories are partly correct, highlighting the need for an integrated model that links to more general cognitive theories to account for observed neural activity during episodic memory retrieval. PMID:21736454

Differential Medial Temporal Lobe and Parietal Cortical Contributions to Real-world Autobiographical Episodic and Autobiographical Semantic Memory.

PubMed

Brown, Thackery I; Rissman, Jesse; Chow, Tiffany E; Uncapher, Melina R; Wagner, Anthony D

2018-04-18

Autobiographical remembering can depend on two forms of memory: episodic (event) memory and autobiographical semantic memory (remembering personally relevant semantic knowledge, independent of recalling a specific experience). There is debate about the degree to which the neural signals that support episodic recollection relate to or build upon autobiographical semantic remembering. Pooling data from two fMRI studies of memory for real-world personal events, we investigated whether medial temporal lobe (MTL) and parietal subregions contribute to autobiographical episodic and semantic remembering. During scanning, participants made memory judgments about photograph sequences depicting past events from their life or from others' lives, and indicated whether memory was based on episodic or semantic knowledge. Results revealed several distinct functional patterns: activity in most MTL subregions was selectively associated with autobiographical episodic memory; the hippocampal tail, superior parietal lobule, and intraparietal sulcus were similarly engaged when memory was based on retrieval of an autobiographical episode or autobiographical semantic knowledge; and angular gyrus demonstrated a graded pattern, with activity declining from autobiographical recollection to autobiographical semantic remembering to correct rejections of novel events. Collectively, our data offer insights into MTL and parietal cortex functional organization, and elucidate circuitry that supports different forms of real-world autobiographical memory.

RBANS Memory Indices Are Related to Medial Temporal Lobe Volumetrics in Healthy Older Adults and Those with Mild Cognitive Impairment

PubMed Central

England, Heather B.; Gillis, M. Meredith; Hampstead, Benjamin M.

2014-01-01

The current study (i) determined whether NeuroQuant® volumetrics are reflective of differences in medial temporal lobe (MTL) volumes between healthy older adults and those with mild cognitive impairment (MCI) and (ii) examined the relationship between RBANS indices and MTL volumes. Forty-three healthy older adults and 57 MCI patients completed the RBANS and underwent structural MRI. Hippocampal and inferior lateral ventricle (ILV) volumes were obtained using NeuroQuant®. Results revealed significantly smaller hippocampal and larger ILV volumes in MCI patients. MTL volumes were significantly related to the RBANS Immediate and Delayed Memory and Language indices but not the Attention or Visuoconstruction indices; findings that demonstrate anatomical specificity. Following discriminant function analysis, we calculated a cutpoint that may prove clinically useful for integrating MTL volumes into the diagnosis of MCI. These findings demonstrate the potential clinical utility of NeuroQuant® and are the first to document the relationship between RBANS indices and MTL volumes. PMID:24709384

Dynamic Causal Modeling of Preclinical Autosomal-Dominant Alzheimer's Disease.

PubMed

Penny, Will; Iglesias-Fuster, Jorge; Quiroz, Yakeel T; Lopera, Francisco Javier; Bobes, Maria A

2018-03-16

Dynamic causal modeling (DCM) is a framework for making inferences about changes in brain connectivity using neuroimaging data. We fitted DCMs to high-density EEG data from subjects performing a semantic picture matching task. The subjects are carriers of the PSEN1 mutation, which leads to early onset Alzheimer's disease, but at the time of EEG acquisition in 1999, these subjects were cognitively unimpaired. We asked 1) what is the optimal model architecture for explaining the event-related potentials in this population, 2) which connections are different between this Presymptomatic Carrier (PreC) group and a Non-Carrier (NonC) group performing the same task, and 3) which network connections are predictive of subsequent Mini-Mental State Exam (MMSE) trajectories. We found 1) a model with hierarchical rather than lateral connections between hemispheres to be optimal, 2) that a pathway from right inferotemporal cortex (IT) to left medial temporal lobe (MTL) was preferentially activated by incongruent items for subjects in the PreC group but not the NonC group, and 3) that increased effective connectivity among left MTL, right IT, and right MTL was predictive of subsequent MMSE scores.

Impaired category fluency in medial temporal lobe amnesia: the role of episodic memory.

PubMed

Greenberg, Daniel L; Keane, Margaret M; Ryan, Lee; Verfaellie, Mieke

2009-09-02

Memory tasks are often classified as semantic or episodic, but recent research shows that these types of memory are highly interactive. Category fluency, for example, is generally considered to reflect retrieval from semantic memory, but behavioral evidence suggests that episodic memory is also involved: participants frequently draw on autobiographical experiences while generating exemplars of certain categories. Neuroimaging studies accordingly have reported increased medial temporal lobe (MTL) activation during exemplar generation. Studies of fluency in MTL amnesics have yielded mixed results but were not designed to determine the precise contributions of episodic memory. We addressed this issue by asking MTL amnesics and controls to generate exemplars of three types of categories. One type tended to elicit autobiographical and spatial retrieval strategies (AS). Another type elicited strategies that were autobiographical but nonspatial (AN). The third type elicited neither autobiographical nor spatial strategies (N). Amnesic patients and control participants generated exemplars for eight categories of each type. Patients were impaired on all category types but were more impaired on AS and AN categories. After covarying for phonemic fluency (total FAS score), the N category impairment was not significant, but the impairment on AS and AN categories remained. The same results were obtained for patients with lesions restricted to the MTL and those with more extensive lesions. We conclude that patients' episodic memory impairment hindered their performance on this putatively semantic task. This interaction between episodic and semantic memory might partially account for fluency deficits seen in aging, mild cognitive impairment, and Alzheimer's disease.

Deformation of the Japanese Islands and seismic coupling: an interpretation based on GSI permanent GPS observations

NASA Astrophysics Data System (ADS)

Le Pichon, Xavier; Mazzotti, Stéphane; Henry, Pierre; Hashimoto, Manabu

1998-08-01

The entire area of the Japanese Islands has been covered by the permanent GPS observation network of the Geographical Survey Institute since 1994. In this paper we use a solution for the vectors of motion during 1995 for a selection of 116 stations to discuss the origin of the observed deformation field. We refer the displacement field to Eurasia using the VLBI-determined motion of Kashima and demonstrate that other choices such as the Okhotsk or North American plates for north Japan are not compatible with the data. 1 yr GPS velocities are much higher than geological constraints would allow because these short-term measurements include transient elastic deformation. However, the good qualitative agreement between the observed geodetic deformation tensors and those inferred from active faults and earthquakes suggests that the Quaternary permanent deformation is essentially the result of the transfer of part of the subduction-induced elastic deformation into permanent plastic deformation. We then compute the elastic deformation of the Japanese Islands caused by interseismic loading of the Pacific and Philippine subduction planes. The geometry of the coupled zone and its downward extension are determined from the distribution of earthquakes for the Pacific slab. For the Philippine slab we use the geometry proposed by Hyndman et al. (1995). These elastic models account for most of the observed velocity field if the subduction movement of the Philippine Sea Plate is 100 per cent locked and if that of the Pacific Plate is 75-85 per cent locked. We note that the boundaries of the areas where significant elastic deformation is predicted (more than 10 mm yr-1 of motion with respect to Eurasia) coincide with the main zones of permanent deformation: the Eastern Japan Sea deformation zone for the Pacific subduction elastic deformation field and the Setouchi/MTL deformation zone for the Nankai field. Each zone probably accommodates 10-15 mm yr-1 of motion in the long term (convergence in the Eastern Japan Sea; strike-slip in the Setouchi/MTL zone). To account for this deformation, the effect of elastic loading from the trench must be combined with 5-10 mm yr-1 of motion of the Amur Plate with respect to Eurasia. Because loading during the subduction earthquake cycle causes an increase in stress in the Eastern Japan Sea and Setouchi/MTL deformation zones, the probability of earthquake occurrence in these zones may be higher near the end of the cycle.

Reward modulation of hippocampal subfield activation during successful associative encoding and retrieval

PubMed Central

Wolosin, Sasha M.; Zeithamova, Dagmar; Preston, Alison R.

2012-01-01

Emerging evidence suggests that motivation enhances episodic memory formation through interactions between medial temporal lobe (MTL) structures and dopaminergic midbrain. In addition, recent theories propose that motivation specifically facilitates hippocampal associative binding processes, resulting in more detailed memories that are readily reinstated from partial input. Here, we used high-resolution functional magnetic resonance imaging to determine how motivation influences associative encoding and retrieval processes within human MTL subregions and dopaminergic midbrain. Participants intentionally encoded object associations under varying conditions of reward and performed a retrieval task during which studied associations were cued from partial input. Behaviorally, cued recall performance was superior for high-value relative to low-value associations; however, participants differed in the degree to which rewards influenced memory. The magnitude of behavioral reward modulation was associated with reward-related activation changes in dentate gyrus/CA2,3 during encoding and enhanced functional connectivity between dentate gyrus/CA2,3 and dopaminergic midbrain during both the encoding and retrieval phases of the task. These findings suggests that within the hippocampus, reward-based motivation specifically enhances dentate gyrus/CA2,3 associative encoding mechanisms through interactions with dopaminergic midbrain. Furthermore, within parahippocampal cortex and dopaminergic midbrain regions, activation associated with successful memory formation was modulated by reward across the group. During the retrieval phase, we also observed enhanced activation in hippocampus and dopaminergic midbrain for high-value associations that occurred in the absence of any explicit cues to reward. Collectively, these findings shed light on fundamental mechanisms through which reward impacts associative memory formation and retrieval through facilitation of MTL and VTA/SN processing. PMID:22524296

Functional MR imaging or Wada test: which is the better predictor of individual postoperative memory outcome?

PubMed

Dupont, Sophie; Duron, Emmanuelle; Samson, Séverine; Denos, Marisa; Volle, Emmanuelle; Delmaire, Christine; Navarro, Vincent; Chiras, Jacques; Lehéricy, Stéphane; Samson, Yves; Baulac, Michel

2010-04-01

To retrospectively determine whether blood oxygen level-dependent functional magnetic resonance (MR) imaging can aid prediction of postoperative memory changes in epileptic patients after temporal lobe surgery. This study was approved by the local ethics committee, and informed consent was obtained from all patients. Data were analyzed from 25 patients (12 women, 13 men; age range, 19-52 years) with refractory epilepsy in whom temporal lobe surgery was performed after they underwent preoperative functional MR imaging, the Wada test, and neuropsychological testing. The functional MR imaging protocol included three different memory tasks (24-hour delayed recognition, encoding, and immediate recognition). Individual activations were measured in medial temporal lobe (MTL) regions of both hemispheres. The prognostic accuracy of functional MR imaging for prediction of postoperative memory changes was compared with the accuracy of the Wada test and preoperative neuropsychological testing by using a backward multiple regression analysis. An equation that was based on left functional MR imaging MTL activation during delayed recognition, side of the epileptic focus, and preoperative global verbal memory score was used to correctly predict worsening of verbal memory in 90% of patients. The right functional MR imaging MTL activation did not substantially correlate with the nonverbal memory outcome, which was only predicted by using the preoperative nonverbal global score. Wada test data were not good predictors of changes in either verbal or nonverbal memory. Findings suggest that functional MR imaging activation during a delayed-recognition task is a better predictor of individual postoperative verbal memory outcome than is the Wada test. RSNA, 2010

The MTL1 Pentatricopeptide Repeat Protein Is Required for Both Translation and Splicing of the Mitochondrial NADH DEHYDROGENASE SUBUNIT7 mRNA in Arabidopsis.

PubMed

Haïli, Nawel; Planchard, Noelya; Arnal, Nadège; Quadrado, Martine; Vrielynck, Nathalie; Dahan, Jennifer; des Francs-Small, Catherine Colas; Mireau, Hakim

2016-01-01

Mitochondrial translation involves a complex interplay of ancient bacteria-like features and host-derived functionalities. Although the basic components of the mitochondrial translation apparatus have been recognized, very few protein factors aiding in recruiting ribosomes on mitochondria-encoded messenger RNA (mRNAs) have been identified in higher plants. In this study, we describe the identification of the Arabidopsis (Arabidopsis thaliana) MITOCHONDRIAL TRANSLATION FACTOR1 (MTL1) protein, a new member of the Pentatricopeptide Repeat family, and show that it is essential for the translation of the mitochondrial NADH dehydrogenase subunit7 (nad7) mRNA. We demonstrate that mtl1 mutant plants fail to accumulate the Nad7 protein, even though the nad7 mature mRNA is produced and bears the same 5' and 3' extremities as in wild-type plants. We next observed that polysome association of nad7 mature mRNA is specifically disrupted in mtl1 mutants, indicating that the absence of Nad7 results from a lack of translation of nad7 mRNA. These findings illustrate that mitochondrial translation requires the intervention of gene-specific nucleus-encoded PPR trans-factors and that their action does not necessarily involve the 5' processing of their target mRNA, as observed previously. Interestingly, a partial decrease in nad7 intron 2 splicing was also detected in mtl1 mutants, suggesting that MTL1 is also involved in group II intron splicing. However, this second function appears to be less essential for nad7 expression than its role in translation. MTL1 will be instrumental to understand the multifunctionality of PPR proteins and the mechanisms governing mRNA translation and intron splicing in plant mitochondria. © 2016 American Society of Plant Biologists. All Rights Reserved.

Evaluation of Consumer Understanding of Different Front-of-Package Nutrition Labels, 2010–2011

PubMed Central

Bragg, Marie A.; Seamans, Marissa J.; Mechulan, Regine L.; Novak, Nicole; Brownell, Kelly D.

2012-01-01

Introduction Governments throughout the world are using or considering various front-of-package (FOP) food labeling systems to provide nutrition information to consumers. Our web-based study tested consumer understanding of different FOP labeling systems. Methods Adult participants (N = 480) were randomized to 1 of 5 groups to evaluate FOP labels: 1) no label; 2) multiple traffic light (MTL); 3) MTL plus daily caloric requirement icon (MTL+caloric intake); 4) traffic light with specific nutrients to limit based on food category (TL+SNL); or 5) the Choices logo. Total percentage correct quiz scores were created reflecting participants’ ability to select the healthier of 2 foods and estimate amounts of saturated fat, sugar, and sodium in foods. Participants also rated products on taste, healthfulness, and how likely they were to purchase the product. Quiz scores and product perceptions were compared with 1-way analysis of variance followed by post-hoc Tukey tests. Results The MTL+caloric intake group (mean [standard deviation], 73.3% [6.9%]) and Choices group (72.5% [13.2%]) significantly outperformed the no label group (67.8% [10.3%]) and the TL+SNL group (65.8% [7.3%]) in selecting the more healthful product on the healthier product quiz. The MTL and MTL+caloric intake groups achieved average scores of more than 90% on the saturated fat, sugar, and sodium quizzes, which were significantly better than the no label and Choices group average scores, which were between 34% and 47%. Conclusion An MTL+caloric intake label and the Choices symbol hold promise as FOP labeling systems and require further testing in different environments and population subgroups. PMID:22995103

Stereochemical course of the reactions catalyzed by the bacterial phosphoenolpyruvate: Mannitol phosphotransferase system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mueller, E.G.; Knowles, J.R.; Khandekar, S.S.

1990-07-24

The authors have determined the overall stereochemical course of the reactions leading to the phosphorylation of D-mannitol by mannitol-specific enzyme II (EII{sup Mtl}) of the Escherichia coli phosphoenolpyruvate- (PEP) dependent phosphotransferase system (PTS). In the presence of enzyme I and HPr of the PTS, and of membranes containing EII{sup Mtl}, the phospho group from ((R)-{sup 16}O, {sup 17}O, {sup 18}O)PEP was transferred to D-mannitol to form mannitol 1-phosphate with overall inversion of the configuration at phosphorus with respect to that of PEP. Since in the course of these reactions enzyme I and HPr are each covalently phosphorylated at a singlemore » site and inversion of the chiral phospho group from PEP indicates an odd number of transfer steps overall, transfer from phospho-HPr to mannitol via EII{sup Mtl} must also occur in an odd number of steps. Taken together with the fact that catalytically important phospho-EII{sup Mtl} intermediates have been demonstrated biochemically, the results imply that EII{sup Mtl} is sequentially phosphorylated at two different sites during phospho transfer from phospho-HPr to mannitol. This conclusion is consistent with the available evidence on phospho-EII{sup Mtl} intermediates and in particular with the recent report that two different phospho peptides can be isolated from the fully phosphorylated protein.« less

The Episodic Memory System: Neurocircuitry and Disorders

PubMed Central

Dickerson, Bradford C; Eichenbaum, Howard

2010-01-01

The ability to encode and retrieve our daily personal experiences, called episodic memory, is supported by the circuitry of the medial temporal lobe (MTL), including the hippocampus, which interacts extensively with a number of specific distributed cortical and subcortical structures. In both animals and humans, evidence from anatomical, neuropsychological, and physiological studies indicates that cortical components of this system have key functions in several aspects of perception and cognition, whereas the MTL structures mediate the organization and persistence of the network of memories whose details are stored in those cortical areas. Structures within the MTL, and particularly the hippocampus, have distinct functions in combining information from multiple cortical streams, supporting our ability to encode and retrieve details of events that compose episodic memories. Conversely, selective damage in the hippocampus, MTL, and other structures of the large-scale memory system, or deterioration of these areas in several diseases and disorders, compromises episodic memory. A growing body of evidence is converging on a functional organization of the cortical, subcortical, and MTL structures that support the fundamental features of episodic memory in humans and animals. PMID:19776728

Effect of animal mixing as a stressor on biomarkers of autophagy and oxidative stress during pig muscle maturation.

PubMed

Rubio-González, A; Potes, Y; Illán-Rodríguez, D; Vega-Naredo, I; Sierra, V; Caballero, B; Fàbrega, E; Velarde, A; Dalmau, A; Oliván, M; Coto-Montes, A

2015-07-01

The objective of this work was to study the postmortem evolution of potential biomarkers of autophagy (Beclin 1, LC3-II/LC3-I ratio) and oxidative stress (total antioxidant activity, TAA; superoxide dismutase activity, SOD and catalase activity, CAT) in the Longissimus dorsi muscle of entire male ((Large White×Landrace)×Duroc) pigs subjected to different management treatments that may promote stress, such as mixing unfamiliar animals at the farm and/or during transport and lairage before slaughter. During the rearing period at the farm, five animals were never mixed after the initial formation of the experimental groups (unmixed group at the farm, UF), whereas 10 animals were subjected to a common routine of being mixed with unfamiliar animals (mixed group at the farm, MF). Furthermore, two different treatments were used during the transport and lairage before slaughter: 10 pigs were not mixed (unmixed group during transport and lairage, UTL), whereas five pigs were mixed with unfamiliar animals on the lorry and during lairage (mixed group during transport and lairage, MTL). These mixing treatments were then combined into three pre-slaughter treatments - namely, UF-UTL, MF-UTL and MF-MTL. The results show that MF-UTL and MF-MTL increased significantly the muscle antioxidant defense (TAA, SOD and CAT) at short postmortem times (4 and 8 h; P<0.001), followed by an earlier depletion of the antioxidant activity at 24 h postmortem (P<0.05). We also found that mixing unfamiliar animals, both at the farm and during transport and lairage, triggers postmortem muscle autophagy, which showed an earlier activation (higher expression of Beclin 1 and LC3-II/LC3-I ratio at 4 h postmortem followed by a decreasing pattern of this ratio along first 24 h postmortem) in the muscle tissues of animals from the MF-UTL and MF-MTL groups, as an adaptive strategy of the muscle cells for counteracting induced stress. From these results, we propose that monitoring the evolution of the main biomarkers of autophagy (Beclin 1, LC3-II/LC3-I ratio) and muscle antioxidant defense (TAA, SOD, CAT) in the muscle tissue within the first 24 h postmortem may help the detection of animal stress and its potential effect on the postmortem muscle metabolism.

Functional and Neuroanatomical Specificity of Episodic Memory Dysfunction in Schizophrenia: An fMRI study of the Relational and Item-Specific Encoding Task

PubMed Central

Ragland, J. Daniel; Ranganath, Charan; Harms, Michael P.; Barch, Deanna M.; Gold, James M.; Layher, Evan; Lesh, Tyler A.; MacDonald, Angus W.; Niendam, Tara A.; Phillips, Joshua; Silverstein, Steven M.; Yonelinas, Andrew P.; Carter, Cameron S.

2015-01-01

Importance Individuals with schizophrenia (SZ) can encode item-specific information to support familiarity-based recognition, but are disproportionately impaired encoding inter-item relationships (relational encoding) and recollecting information. The Relational and Item-Specific Encoding (RiSE) paradigm has been used to disentangle these encoding and retrieval processes, which may be dependent on specific medial temporal lobe (MTL) and prefrontal cortex (PFC) subregions. Functional imaging during RiSE task performance could help to specify dysfunctional neural circuits in SZ that can be targeted for interventions to improve memory and functioning in the illness. Objectives To use functional magnetic resonance imaging (fMRI) to test the hypothesis that SZ disproportionately affects MTL and PFC subregions during relational encoding and retrieval, relative to item-specific memory processes. Imaging results from healthy comparison subjects (HC) will also be used to establish neural construct validity for RiSE. Design, Setting, and Participants This multi-site, case-control, cross-sectional fMRI study was conducted at five CNTRACS sites. The final sample included 52 clinically stable outpatients with SZ, and 57 demographically matched HC. Main Outcomes and Measures Behavioral performance speed and accuracy (d’) on item recognition and associative recognition tasks. Voxelwise statistical parametric maps for a priori MTL and PFC regions of interest (ROI), testing activation differences between relational and item-specific memory during encoding and retrieval. Results Item recognition was disproportionately impaired in SZ patients relative to controls following relational encoding. The differential deficit was accompanied by reduced dorsolateral prefrontal cortex (DLPFC) activation during relational encoding in SZ, relative to HC. Retrieval success (hits > misses) was associated with hippocampal (HI) activation in HC during relational item recognition and associative recognition conditions, and HI activation was specifically reduced in SZ for recognition of relational but not item-specific information. Conclusions In this unique, multi-site fMRI study, HC results supported RiSE construct validity by revealing expected memory effects in PFC and MTL subregions during encoding and retrieval. Comparison of SZ and HC revealed disproportionate memory deficits in SZ for relational versus item-specific information, accompanied by regionally and functionally specific deficits in DLPFC and HI activation. PMID:26200928

Episodic reinstatement in the medial temporal lobe.

PubMed

Staresina, Bernhard P; Henson, Richard N A; Kriegeskorte, Nikolaus; Alink, Arjen

2012-12-12

The essence of episodic memory is our ability to reexperience past events in great detail, even in the absence of external stimulus cues. Does the phenomenological reinstatement of past experiences go along with reinstating unique neural representations in the brain? And if so, how is this accomplished by the medial temporal lobe (MTL), a brain region intimately linked to episodic memory? Computational models suggest that such reinstatement (also termed "pattern completion") in cortical regions is mediated by the hippocampus, a key region of the MTL. Although recent functional magnetic resonance imaging studies demonstrated reinstatement of coarse item properties like stimulus category or task context across different brain regions, it has not yet been shown whether reinstatement can be observed at the level of individual, discrete events-arguably the defining feature of episodic memory-nor whether MTL structures like the hippocampus support this "true episodic" reinstatement. Here we show that neural activity patterns for unique word-scene combinations encountered during encoding are reinstated in human parahippocampal cortex (PhC) during retrieval. Critically, this reinstatement occurs when word-scene combinations are successfully recollected (even though the original scene is not visually presented) and does not encompass other stimulus domains (such as word-color associations). Finally, the degree of PhC reinstatement across retrieval events correlated with hippocampal activity, consistent with a role of the hippocampus in coordinating pattern completion in cortical regions.

Visuo-spatial memory deficits following medial temporal lobe damage: A comparison of three patient groups.

PubMed

Esfahani-Bayerl, Nazli; Finke, Carsten; Braun, Mischa; Düzel, Emrah; Heekeren, Hauke R; Holtkamp, Martin; Hasper, Dietrich; Storm, Christian; Ploner, Christoph J

2016-01-29

The contributions of the hippocampal formation and adjacent regions of the medial temporal lobe (MTL) to memory are still a matter of debate. It is currently unclear, to what extent discrepancies between previous human lesion studies may have been caused by the choice of distinct patient models of MTL dysfunction, as disorders affecting this region differ in selectivity, laterality and mechanisms of post-lesional compensation. Here, we investigated the performance of three distinct patient groups with lesions to the MTL with a battery of visuo-spatial short-term memory tasks. Thirty-one subjects with either unilateral damage to the MTL (postsurgical lesions following resection of a benign brain tumor, 6 right-sided lesions, 5 left) or bilateral damage (10 post-encephalitic lesions, 10 post-anoxic lesions) performed a series of tasks requiring short-term memory of colors, locations or color-location associations. We have shown previously that performance in the association task critically depends on hippocampal integrity. Patients with postsurgical damage of the MTL showed deficient performance in the association task, but performed normally in color and location tasks. Patients with left-sided lesions were almost as impaired as patients with right-sided lesions. Patients with bilateral post-encephalitic lesions showed comparable damage to MTL sub-regions and performed similarly to patients with postsurgical lesions in the association task. However, post-encephalitic patients showed additional impairments in the non-associative color and location tasks. A strikingly similar pattern of deficits was observed in post-anoxic patients. These results suggest a distinct cerebral organization of associative and non-associative short-term memory that was differentially affected in the three patient groups. Thus, while all patient groups may provide appropriate models of medial temporal lobe dysfunction in associative visuo-spatial short-term memory, additional deficits in non-associative memory tasks likely reflect damage of regions outside the MTL. Importantly, the choice of a patient model in human lesion studies of the MTL significantly influences overall performance patterns in visuo-spatial memory tasks. Copyright © 2015 Elsevier Ltd. All rights reserved.

Association of perception of front-of-pack labels with dietary, lifestyle and health characteristics.

PubMed

Méjean, Caroline; Macouillard, Pauline; Péneau, Sandrine; Lassale, Camille; Hercberg, Serge; Castetbon, Katia

2014-01-01

To identify patterns of perception of front-of-pack (FOP) nutrition labels and determine dietary, lifestyle and health profiles related to such patterns. Cross-sectional. 28,952 French adults participating in the web-based Nutrinet-Santé cohort. Perception was measured using indicators of understanding and acceptability for three simple FOP labels ("green tick", the logo of the French Nutrition and Health Program and "simple traffic lights" (STL)), and two detailed FOP formats ("multiple traffic lights" (MTL) and "color range" logo (CR)), placed on ready-to-eat soup packages. Dietary intake data were collected using three web-based 24 h records. Associations of perception patterns with individual characteristics, including diet, lifestyle and health status, were examined using analysis of covariance and logistic regression, adjusted for socio-demographic and economic factors. No clear trend emerged concerning differences in dietary intake between perception groups. Low physical activity and obesity were more frequent in the 'favorable to STL' group (respectively, 20.7% and 10.7%). The 'favorable to MTL' group included the highest percentage of individuals who declared type 2 diabetes (2.2%). Persons with hypertension were proportionally more numerous in the 'favorable to MTL' and the 'favorable to CR logo' groups (respectively, 9.5% and 9.3%). After adjustment for socio-demographic and economic factors, no FOP label stood out as being more suitable than another for reaching populations with poor diet. However, both STL and MTL may be most appropriate for increasing awareness of healthy eating among groups at higher risk of nutrition-related chronic diseases.

Interpretive front-of-pack nutrition labels. Comparing competing recommendations.

PubMed

Maubach, Ninya; Hoek, Janet; Mather, Damien

2014-11-01

Many stakeholders support introducing an interpretive front-of-pack (FOP) nutrition label, but disagree over the form it should take. In late 2012, an expert working group established by the New Zealand government recommended the adoption of an untested summary rating system: a Star label. This study used a best-worst scaling choice experiment to estimate how labels featuring the new Star rating, the Multiple Traffic Light (MTL), Daily Intake Guide (DIG), and a no-FOP control affected consumers' choice behaviours and product perceptions. Nutrient-content and health claims were included in the design. We also assessed whether respondents who used more or less information during the choice tasks differed in their selection patterns. Overall, while respondents made broadly similar choices with respect to the MTL and Star labels, the MTL format had a significantly greater impact on depressing preference as a food's nutritional profile became less healthy. Health claims increased rankings of less nutritious options, though this effect was less pronounced when the products featured an MTL. Further, respondents were best able to differentiate products' healthiness with MTL labels. The proposed summary Stars system had less effect on choice patterns than an MTL label and our findings highlight the need for policy makers to ensure that decisions to introduce FOP labels are underpinned by robust research evidence. These results suggest that the proposed summary Stars system will have less effect on shifting food choice patterns than interpretive FOP nutrition label featuring traffic light ratings. Copyright © 2014 Elsevier Ltd. All rights reserved.

A new method for assessing the impact of medial temporal lobe amnesia on the characteristics of generated autobiographical events.

PubMed

Lenton-Brym, Ariella; Kurczek, Jake; Rosenbaum, R Shayna; Sheldon, Signy

2016-05-01

Constructing autobiographical events involves an initial phase of event selection, in which a memory or imagined future event is initially brought to mind, followed by a phase of elaboration, in which an individual accesses detailed knowledge specific to the event. While considerable research demonstrates the importance of the medial temporal lobes (MTL) in the later phase, its role in initial event selection is unknown. The present study is the first to investigate the role of the MTL in event selection by assessing whether individuals with MTL lesions select qualitatively different events for remembering and imagining than matched control participants. To do so, we created "event captions" that reflected the type of events selected for an autobiographical event narrative task by four individuals with MTL amnesia and control counterparts. Over 450 online raters assessed these event captions on qualitative dimensions known to vary with autobiographical recall (frequency, significance, emotionality, imageability, and uniqueness). Our critical finding was that individuals with MTL amnesia were more prone to select events that were rated as more frequently occurring than healthy control participants. We interpret this finding as evidence that people with impaired episodic memory from MTL damage compensate for their compromised ability to recall detailed information by relying more heavily on semantic memory processes to select generalized events. We discuss the implications for theoretical models of memory and methodological approaches to studying autobiographical memory. Copyright © 2016 Elsevier Ltd. All rights reserved.

Montreal-Toulouse Language Assessment Battery: evidence of criterion validity from patients with aphasia.

PubMed

Pagliarin, Karina Carlesso; Ortiz, Karin Zazo; Barreto, Simone dos Santos; Pimenta Parente, Maria Alice de Mattos; Nespoulous, Jean-Luc; Joanette, Yves; Fonseca, Rochele Paz

2015-10-15

The Montreal-Toulouse Language Assessment Battery - Brazilian version (MTL-BR) provides a general description of language processing and related components in adults with brain injury. The present study aimed at verifying the criterion-related validity of the Montreal-Toulouse Language Assessment Battery - Brazilian version (MTL-BR) by assessing its ability to discriminate between individuals with unilateral brain damage with and without aphasia. The investigation was carried out in a Brazilian community-based sample of 104 adults, divided into four groups: 26 participants with left hemisphere damage (LHD) with aphasia, 25 participants with right hemisphere damage (RHD), 28 with LHD non-aphasic, and 25 healthy adults. There were significant differences between patients with aphasia and the other groups on most total and subtotal scores on MTL-BR tasks. The results showed strong criterion-related validity evidence for the MTL-BR Battery, and provided important information regarding hemispheric specialization and interhemispheric cooperation. Future research is required to search for additional evidence of sensitivity, specificity and validity of the MTL-BR in samples with different types of aphasia and degrees of language impairment. Copyright © 2015 Elsevier B.V. All rights reserved.

RBANS memory indices are related to medial temporal lobe volumetrics in healthy older adults and those with mild cognitive impairment.

PubMed

England, Heather B; Gillis, M Meredith; Hampstead, Benjamin M

2014-06-01

The current study (i) determined whether NeuroQuant(®) volumetrics are reflective of differences in medial temporal lobe (MTL) volumes between healthy older adults and those with mild cognitive impairment (MCI) and (ii) examined the relationship between RBANS indices and MTL volumes. Forty-three healthy older adults and 57 MCI patients completed the RBANS and underwent structural MRI. Hippocampal and inferior lateral ventricle (ILV) volumes were obtained using NeuroQuant(®). Results revealed significantly smaller hippocampal and larger ILV volumes in MCI patients. MTL volumes were significantly related to the RBANS Immediate and Delayed Memory and Language indices but not the Attention or Visuoconstruction indices; findings that demonstrate anatomical specificity. Following discriminant function analysis, we calculated a cutpoint that may prove clinically useful for integrating MTL volumes into the diagnosis of MCI. These findings demonstrate the potential clinical utility of NeuroQuant(®) and are the first to document the relationship between RBANS indices and MTL volumes. Published by Oxford University Press 2014. This work is written by (a) US Government employee(s) and is in the public domain in the US.

Designing green derivatives of β-blocker Metoprolol: a tiered approach for green and sustainable pharmacy and chemistry.

PubMed

Rastogi, Tushar; Leder, Christoph; Kümmerer, Klaus

2014-09-01

The presences of micro-pollutants (active pharmaceutical ingredients, APIs) are increasingly seen as a challenge of the sustainable management of water resources worldwide due to ineffective effluent treatment and other measures for their input prevention. Therefore, novel approaches are needed like designing greener pharmaceuticals, i.e. better biodegradability in the environment. This study addresses a tiered approach of implementing green and sustainable chemistry principles for theoretically designing better biodegradable and pharmacologically improved pharmaceuticals. Photodegradation process coupled with LC-MS(n) analysis and in silico tools such as quantitative structure-activity relationships (QSAR) analysis and molecular docking proved to be a very significant approach for the preliminary stages of designing chemical structures that would fit into the "benign by design" concept in the direction of green and sustainable pharmacy. Metoprolol (MTL) was used as an example, which itself is not readily biodegradable under conditions found in sewage treatment and the aquatic environment. The study provides the theoretical design of new derivatives of MTL which might have the same or improved pharmacological activity and are more degradable in the environment than MTL. However, the in silico toxicity prediction by QSAR of those photo-TPs indicated few of them might be possibly mutagenic and require further testing. This novel approach of theoretically designing 'green' pharmaceuticals can be considered as a step forward towards the green and sustainable pharmacy field. However, more knowledge and further experience have to be collected on the full scope, opportunities and limitations of this approach. Copyright © 2014 Elsevier Ltd. All rights reserved.

The interaction of rhinal cortex and hippocampus in human declarative memory formation.

PubMed

Fell, Jürgen; Klaver, Peter; Elger, Christian E; Fernández, Guillén

2002-01-01

Human declarative memory formation crucially depends on processes within the medial temporal lobe (MTL). These processes can be monitored in real-time by recordings from depth electrodes implanted in the MTL of patients with epilepsy who undergo presurgical evaluation. In our studies, patients performed a word memorization task during depth EEG recording. Afterwards, the difference between event-related potentials (ERPs) corresponding to subsequently remembered versus forgotten words was analyzed. These kind of studies revealed that successful memory encoding is characterized by an early process generated by the rhinal cortex within 300 ms following stimulus onset. This rhinal process precedes a hippocampal process, which starts about 200 ms later. Further investigation revealed that the rhinal process seems to be a correlate of semantic preprocessing which supports memory formation, whereas the hippocampal process appears to be a correlate of an exclusively mnemonic operation. These studies yielded only indirect evidence for an interaction of rhinal cortex and hippocampus. Direct evidence for a memory related cooperation between both structures, however, has been found in a study analyzing so called gamma activity, EEG oscillations of around 40 Hz. This investigation showed that successful as opposed to unsuccessful memory formation is accompanied by an initial enhancement of rhinal-hippocampal phase synchronization, which is followed by a later desynchronization. Present knowledge about the function of phase synchronized gamma activity suggests that this phase coupling and decoupling initiates and later terminates communication between the two MTL structures. Phase synchronized rhinal-hippocampal gamma activity may, moreover, accomplish Hebbian synaptic modifications and thus provide an initial step of declarative memory formation on the synaptic level.

Medial temporal lobe structure and cognition in individuals with schizophrenia and in their non-psychotic siblings.

PubMed

Karnik-Henry, Meghana S; Wang, Lei; Barch, Deanna M; Harms, Michael P; Campanella, Carolina; Csernansky, John G

2012-07-01

Medial temporal lobe (MTL) structures play a central role in episodic memory. Prior studies suggest that individuals with schizophrenia have deficits in episodic memory as well as structural abnormalities of the medial temporal lobe (MTL). While correlations have been reported between MTL volume loss and episodic memory deficits in such individuals, it is not clear whether such correlations reflect the influence of the disease state or of underlying genetic influences that might contribute to risk. We used high resolution magnetic resonance imaging and probabilistic algorithms for image analysis to determine whether MTL structure, episodic memory performance and the relationship between the two differed among groups of 47 healthy control subjects, 50 control siblings, 39 schizophrenia subjects, and 33 siblings of schizophrenia subjects. High-dimensional large deformation brain mapping was used to obtain volume measures of the hippocampus. Cortical distance mapping was used to obtain volume and thickness measures of the parahippocampal gyrus (PHG) and its substructures: the entorhinal cortex (ERC), the perirhinal cortex (PRC), and the parahippocampal cortex (PHC). Neuropsychological data was used to establish an episodic memory domain score for each subject. Both schizophrenia subjects and their siblings displayed abnormalities in episodic memory performance. Siblings of individuals with schizophrenia, and to a lesser extent, individuals with schizophrenia themselves, displayed abnormalities in measures of MTL structure (volume loss or cortical thinning) as compared to control groups. Further, we observed correlations between structural measures and memory performance in both schizophrenia subjects and their siblings, but not in their respective control groups. These findings suggest that disease-specific genetic factors present in both patients and their relatives may be responsible for correlated abnormalities of MTL structure and memory impairment. The observed attenuated effect of such factors on MTL structure in individuals with schizophrenia may be due to non-genetic influences related to the development and progression of the disease on global brain structure and cognitive processing. Copyright © 2012 Elsevier B.V. All rights reserved.

Correlation between hippocampal volumes and medial temporal lobe atrophy in patients with Alzheimer's disease.

PubMed

Dhikav, Vikas; Duraiswamy, Sharmila; Anand, Kuljeet Singh

2017-01-01

Hippocampus undergoes atrophy in patients with Alzheimer's disease (AD). Calculation of hippocampal volumes can be done by a variety of methods using T1-weighted images of magnetic resonance imaging (MRI) of the brain. Medial temporal lobes atrophy (MTL) can be rated visually using T1-weighted MRI brain images. The present study was done to see if any correlation existed between hippocampal volumes and visual rating scores of the MTL using Scheltens Visual Rating Method. We screened 84 subjects presented to the Department of Neurology of a Tertiary Care Hospital and enrolled forty subjects meeting the National Institute of Neurological and Communicative Disorders and Stroke, AD related Disease Association criteria. Selected patients underwent MRI brain and T1-weighted images in a plane perpendicular to long axis of hippocampus were obtained. Hippocampal volumes were calculated manually using a standard protocol. The calculated hippocampal volumes were correlated with Scheltens Visual Rating Method for Rating MTL. A total of 32 cognitively normal age-matched subjects were selected to see the same correlation in the healthy subjects as well. Sensitivity and specificity of both methods was calculated and compared. There was an insignificant correlation between the hippocampal volumes and MTL rating scores in cognitively normal elderly ( n = 32; Pearson Correlation coefficient = 0.16, P > 0.05). In the AD Group, there was a moderately strong correlation between measured hippocampal volumes and MTL Rating (Pearson's correlation coefficient = -0.54; P < 0.05. There was a moderately strong correlation between hippocampal volume and Mini-Mental Status Examination in the AD group. Manual delineation was superior compared to the visual method ( P < 0.05). Good correlation was present between manual hippocampal volume measurements and MTL scores. Sensitivity and specificity of manual measurement of hippocampus was higher compared to visual rating scores for MTL in patients with AD.

Correlation between hippocampal volumes and medial temporal lobe atrophy in patients with Alzheimer's disease

PubMed Central

Dhikav, Vikas; Duraiswamy, Sharmila; Anand, Kuljeet Singh

2017-01-01

Introduction: Hippocampus undergoes atrophy in patients with Alzheimer's disease (AD). Calculation of hippocampal volumes can be done by a variety of methods using T1-weighted images of magnetic resonance imaging (MRI) of the brain. Medial temporal lobes atrophy (MTL) can be rated visually using T1-weighted MRI brain images. The present study was done to see if any correlation existed between hippocampal volumes and visual rating scores of the MTL using Scheltens Visual Rating Method. Materials and Methods: We screened 84 subjects presented to the Department of Neurology of a Tertiary Care Hospital and enrolled forty subjects meeting the National Institute of Neurological and Communicative Disorders and Stroke, AD related Disease Association criteria. Selected patients underwent MRI brain and T1-weighted images in a plane perpendicular to long axis of hippocampus were obtained. Hippocampal volumes were calculated manually using a standard protocol. The calculated hippocampal volumes were correlated with Scheltens Visual Rating Method for Rating MTL. A total of 32 cognitively normal age-matched subjects were selected to see the same correlation in the healthy subjects as well. Sensitivity and specificity of both methods was calculated and compared. Results: There was an insignificant correlation between the hippocampal volumes and MTL rating scores in cognitively normal elderly (n = 32; Pearson Correlation coefficient = 0.16, P > 0.05). In the AD Group, there was a moderately strong correlation between measured hippocampal volumes and MTL Rating (Pearson's correlation coefficient = −0.54; P < 0.05. There was a moderately strong correlation between hippocampal volume and Mini-Mental Status Examination in the AD group. Manual delineation was superior compared to the visual method (P < 0.05). Conclusions: Good correlation was present between manual hippocampal volume measurements and MTL scores. Sensitivity and specificity of manual measurement of hippocampus was higher compared to visual rating scores for MTL in patients with AD. PMID:28298839

Measurement of Liver Stiffness Using Shear Wave Elastography in a Rat Model: Factors Impacting Stiffness Measurement with Multiple- and Single-Tracking-Location Techniques.

PubMed

Langdon, Jonathan H; Elegbe, Etana; Gonzalez, Raul S; Osapoetra, Laurentius; Ford, Tristan; McAleavey, Stephen A

2017-11-01

The clinical use of elastography for monitoring fibrosis progression is challenged by the subtle changes in liver stiffness associated with early-stage fibrosis and the comparatively large variance in stiffness estimates provided by elastography. Single-tracking-location (STL) shear wave elasticity imaging (SWEI) is an ultrasound elastography technique previously found to provide improved estimate precision compared with multiple-tracking-location (MTL) SWEI. Because of the improved precision, it is reasonable to expect that STL-SWEI would provide improved ability to differentiate liver fibrosis stage compared with MTL-SWEI. However, this expectation has not been previously challenged rigorously. In this work, the performance of STL- and MTL-SWEI in the setting of a rat model of liver fibrosis is characterized, and the advantages of STL-SWEI in staging fibrosis are explored. The purpose of this study was to determine what advantages, if any, arise from using STL-SWEI instead of MTL-SWEI in the characterization of fibrotic liver. Thus, the ability of STL-SWEI to differentiate livers at various METAVIR fibrosis scores, for ex vivo postmortem measurements, is explored. In addition, we examined the effect of the common confounding factor of fluid versus solid boundary conditions in SWEI experiments. Sprague-Dawley rats were treated with carbon tetrachloride over several weeks to produce liver disease of varying severity. STL and MTL stiffness measurements were performed ex vivo and compared with the METAVIR scores from histological analysis and the duration of treatment. A strong association was observed between liver stiffness and weeks of treatment with the liver toxin carbon tetrachloride. Direct comparison of STL- and MTL-SWEI measurements revealed no significant difference in ability to differentiate fibrosis stages based on SWEI mean values. However, image interquartile range was greatly improved in the case of STL-SWEI, compared with MTL-SWEI, at small beam spacing. Copyright © 2017 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.

Retrieval of high-fidelity memory arises from distributed cortical networks.

PubMed

Wais, Peter E; Jahanikia, Sahar; Steiner, Daniel; Stark, Craig E L; Gazzaley, Adam

2017-04-01

Medial temporal lobe (MTL) function is well established as necessary for memory of facts and events. It is likely that lateral cortical regions critically guide cognitive control processes to tune in high-fidelity details that are most relevant for memory retrieval. Here, convergent results from functional and structural MRI show that retrieval of detailed episodic memory arises from lateral cortical-MTL networks, including regions of inferior frontal and angular gyrii. Results also suggest that recognition of items based on low-fidelity, generalized information, rather than memory arising from retrieval of relevant episodic details, is not associated with functional connectivity between MTL and lateral cortical regions. Additionally, individual differences in microstructural properties in white matter pathways, associated with distributed MTL-cortical networks, are positively correlated with better performance on a mnemonic discrimination task. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

Anterior Medial Temporal Lobe Activation during Encoding of Words: FMRI Methods to Optimize Sensitivity

ERIC Educational Resources Information Center

Parsons, Michael W.; Haut, Marc W.; Lemieux, Susan K.; Moran, Maria T.; Leach, Sharon G.

2006-01-01

The existence of a rostrocaudal gradient of medial temporal lobe (MTL) activation during memory encoding has historically received support from positron emission tomography studies, but less so from functional MRI (FMRI) studies. More recently, FMRI studies have demonstrated that characteristics of the stimuli can affect the location of activation…

White-Opaque Switching in Natural MTLa/α Isolates of Candida albicans: Evolutionary Implications for Roles in Host Adaptation, Pathogenesis, and Sex

PubMed Central

Nobile, Clarissa J.; Tong, Yaojun; Guan, Guobo; Sun, Yuan; Cao, Chengjun; Hernday, Aaron D.; Johnson, Alexander D.; Zhang, Lixin; Bai, Feng-Yan; Huang, Guanghua

2013-01-01

Phenotypic transitions play critical roles in host adaptation, virulence, and sexual reproduction in pathogenic fungi. A minority of natural isolates of Candida albicans, which are homozygous at the mating type locus (MTL, a/a or α/α), are known to be able to switch between two distinct cell types: white and opaque. It is puzzling that white-opaque switching has never been observed in the majority of natural C. albicans strains that have heterozygous MTL genotypes (a/α), given that they contain all of the opaque-specific genes essential for switching. Here we report the discovery of white-opaque switching in a number of natural a/α strains of C. albicans under a condition mimicking aspects of the host environment. The optimal condition for white-to-opaque switching in a/α strains of C. albicans is to use N-acetylglucosamine (GlcNAc) as the sole carbon source and to incubate the cells in 5% CO2. Although the induction of white-to-opaque switching in a/α strains of C. albicans is not as robust as in MTL homozygotes in response to GlcNAc and CO2, opaque cells of a/α strains exhibit similar features of cellular and colony morphology to their MTL homozygous counterparts. Like MTL homozygotes, white and opaque cells of a/α strains differ in their behavior in different mouse infection models. We have further demonstrated that the transcriptional regulators Rfg1, Brg1, and Efg1 are involved in the regulation of white-to-opaque switching in a/α strains. We propose that the integration of multiple environmental cues and the activation and inactivation of a set of transcriptional regulators controls the expression of the master switching regulator WOR1, which determines the final fate of the cell type in C. albicans. Our discovery of white-opaque switching in the majority of natural a/α strains of C. albicans emphasizes its widespread nature and importance in host adaptation, pathogenesis, and parasexual reproduction. PMID:23555196

Dynamic Neural Networks Supporting Memory Retrieval

PubMed Central

St. Jacques, Peggy L.; Kragel, Philip A.; Rubin, David C.

2011-01-01

How do separate neural networks interact to support complex cognitive processes such as remembrance of the personal past? Autobiographical memory (AM) retrieval recruits a consistent pattern of activation that potentially comprises multiple neural networks. However, it is unclear how such large-scale neural networks interact and are modulated by properties of the memory retrieval process. In the present functional MRI (fMRI) study, we combined independent component analysis (ICA) and dynamic causal modeling (DCM) to understand the neural networks supporting AM retrieval. ICA revealed four task-related components consistent with the previous literature: 1) Medial Prefrontal Cortex (PFC) Network, associated with self-referential processes, 2) Medial Temporal Lobe (MTL) Network, associated with memory, 3) Frontoparietal Network, associated with strategic search, and 4) Cingulooperculum Network, associated with goal maintenance. DCM analysis revealed that the medial PFC network drove activation within the system, consistent with the importance of this network to AM retrieval. Additionally, memory accessibility and recollection uniquely altered connectivity between these neural networks. Recollection modulated the influence of the medial PFC on the MTL network during elaboration, suggesting that greater connectivity among subsystems of the default network supports greater re-experience. In contrast, memory accessibility modulated the influence of frontoparietal and MTL networks on the medial PFC network, suggesting that ease of retrieval involves greater fluency among the multiple networks contributing to AM. These results show the integration between neural networks supporting AM retrieval and the modulation of network connectivity by behavior. PMID:21550407

Solution structure of the phosphoryl transfer complex between the cytoplasmic A domain of the mannitol transporter IIMannitol and HPr of the Escherichia coli phosphotransferase system.

PubMed

Cornilescu, Gabriel; Lee, Byeong Ryong; Cornilescu, Claudia C; Wang, Guangshun; Peterkofsky, Alan; Clore, G Marius

2002-11-01

The solution structure of the complex between the cytoplasmic A domain (IIA(Mtl)) of the mannitol transporter II(Mannitol) and the histidine-containing phosphocarrier protein (HPr) of the Escherichia coli phosphotransferase system has been solved by NMR, including the use of conjoined rigid body/torsion angle dynamics, and residual dipolar couplings, coupled with cross-validation, to permit accurate orientation of the two proteins. A convex surface on HPr, formed by helices 1 and 2, interacts with a complementary concave depression on the surface of IIA(Mtl) formed by helix 3, portions of helices 2 and 4, and beta-strands 2 and 3. The majority of intermolecular contacts are hydrophobic, with a small number of electrostatic interactions at the periphery of the interface. The active site histidines, His-15 of HPr and His-65 of IIA(Mtl), are in close spatial proximity, and a pentacoordinate phosphoryl transition state can be readily accommodated with no change in protein-protein orientation and only minimal perturbations of the backbone immediately adjacent to the histidines. Comparison with two previously solved structures of complexes of HPr with partner proteins of the phosphotransferase system, the N-terminal domain of enzyme I (EIN) and enzyme IIA(Glucose) (IIA(Glc)), reveals a number of common features despite the fact that EIN, IIA(Glc), and IIA(Mtl) bear no structural resemblance to one another. Thus, entirely different underlying structural elements can form binding surfaces for HPr that are similar in terms of both shape and residue composition. These structural comparisons illustrate the roles of surface and residue complementarity, redundancy, incremental build-up of specificity and conformational side chain plasticity in the formation of transient specific protein-protein complexes in signal transduction pathways.

Medial temporal and neocortical contributions to remote memory for semantic narratives: evidence from amnesia.

PubMed

Verfaellie, Mieke; Bousquet, Kathryn; Keane, Margaret M

2014-08-01

Studies of remote memory for semantic facts and concepts suggest that hippocampal lesions lead to a temporally graded impairment that extends no more than ten years prior to the onset of amnesia. Such findings have led to the notion that once consolidated, semantic memories are represented neocortically and are no longer dependent on the hippocampus. Here, we examined the fate of well-established semantic narratives following medial temporal lobe (MTL) lesions. Seven amnesic patients, five with lesions restricted to the MTL and two with lesions extending into lateral temporal cortex (MTL+), were asked to recount fairy tales and bible stories that they rated as familiar. Narratives were scored for number and type of details, number of main thematic elements, and order in which the main thematic elements were recounted. In comparison to controls, patients with MTL lesions produced fewer details, but the number and order of main thematic elements generated was intact. By contrast, patients with MTL+ lesions showed a pervasive impairment, affecting not only the generation of details, but also the generation and ordering of main steps. These findings challenge the notion that, once consolidated, semantic memories are no longer dependent on the hippocampus for retrieval. Possible hippocampal contributions to the retrieval of detailed semantic narratives are discussed. Published by Elsevier Ltd.

Distinct white matter injury associated with medial temporal lobe atrophy in Alzheimer's versus semantic dementia.

PubMed

Bejanin, Alexandre; Desgranges, Béatrice; La Joie, Renaud; Landeau, Brigitte; Perrotin, Audrey; Mézenge, Florence; Belliard, Serge; de La Sayette, Vincent; Eustache, Francis; Chételat, Gaël

2017-04-01

This study aims at further understanding the distinct vulnerability of brain networks in Alzheimer's disease (AD) versus semantic dementia (SD) investigating the white matter injury associated with medial temporal lobe (MTL) atrophy in both conditions. Twenty-six AD patients, twenty-one SD patients, and thirty-nine controls underwent a high-resolution T1-MRI scan allowing to obtain maps of grey matter volume and white matter density. A statistical conjunction approach was used to identify MTL regions showing grey matter atrophy in both patient groups. The relationship between this common grey matter atrophy and white matter density maps was then assessed within each patient group. Patterns of grey matter atrophy were distinct in AD and SD but included a common region in the MTL, encompassing the hippocampus and amygdala. This common atrophy was associated with alterations in different white matter areas in AD versus SD, mainly including the cingulum and corpus callosum in AD, while restricted to the temporal lobe - essentially the uncinate and inferior longitudinal fasciculi - in SD. Complementary analyses revealed that these relationships remained significant when controlling for global atrophy or disease severity. Overall, this study provides the first evidence that atrophy of the same MTL region is related to damage in distinct white matter fibers in AD and SD. These different patterns emphasize the vulnerability of distinct brain networks related to the MTL in these two disorders, which might underlie the discrepancy in their symptoms. These results further suggest differences between AD and SD in the neuropathological processes occurring in the MTL. Hum Brain Mapp 38:1791-1800, 2017. © 2017 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Sleep-Effects on Implicit and Explicit Memory in Repeated Visual Search

PubMed Central

Assumpcao, Leonardo; Gais, Steffen

2013-01-01

In repeated visual search tasks, facilitation of reaction times (RTs) due to repetition of the spatial arrangement of items occurs independently of RT facilitation due to improvements in general task performance. Whereas the latter represents typical procedural learning, the former is a kind of implicit memory that depends on the medial temporal lobe (MTL) memory system and is impaired in patients with amnesia. A third type of memory that develops during visual search is the observers’ explicit knowledge of repeated displays. Here, we used a visual search task to investigate whether procedural memory, implicit contextual cueing, and explicit knowledge of repeated configurations, which all arise independently from the same set of stimuli, are influenced by sleep. Observers participated in two experimental sessions, separated by either a nap or a controlled rest period. In each of the two sessions, they performed a visual search task in combination with an explicit recognition task. We found that (1) across sessions, MTL-independent procedural learning was more pronounced for the nap than rest group. This confirms earlier findings, albeit from different motor and perceptual tasks, showing that procedural memory can benefit from sleep. (2) Likewise, the sleep group compared with the rest group showed enhanced context-dependent configural learning in the second session. This is a novel finding, indicating that the MTL-dependent, implicit memory underlying contextual cueing is also sleep-dependent. (3) By contrast, sleep and wake groups displayed equivalent improvements in explicit recognition memory in the second session. Overall, the current study shows that sleep affects MTL-dependent as well as MTL-independent memory, but it affects different, albeit simultaneously acquired, forms of MTL-dependent memory differentially. PMID:23936363

Age differences in the intrinsic functional connectivity of default network subsystems

PubMed Central

Campbell, Karen L.; Grigg, Omer; Saverino, Cristina; Churchill, Nathan; Grady, Cheryl L.

2013-01-01

Recent work suggests that the default mode network (DMN) includes two core regions, the ventromedial prefrontal cortex and posterior cingulate cortex (PCC), and several unique subsystems that are functionally distinct. These include a medial temporal lobe (MTL) subsystem, active during remembering and future projection, and a dorsomedial prefrontal cortex (dmPFC) subsystem, active during self-reference. The PCC has been further subdivided into ventral (vPCC) and dorsal (dPCC) regions that are more strongly connected with the DMN and cognitive control networks, respectively. The goal of this study was to examine age differences in resting state functional connectivity within these subsystems. After applying a rigorous procedure to reduce the effects of head motion, we used a multivariate technique to identify both common and unique patterns of functional connectivity in the MTL vs. the dmPFC, and in vPCC vs. dPCC. All four areas had robust functional connectivity with other DMN regions, and each also showed distinct connectivity patterns in both age groups. Young and older adults had equivalent functional connectivity in the MTL subsystem. Older adults showed weaker connectivity in the vPCC and dmPFC subsystems, particularly with other DMN areas, but stronger connectivity than younger adults in the dPCC subsystem, which included areas involved in cognitive control. Our data provide evidence for distinct subsystems involving DMN nodes, which are maintained with age. Nevertheless, there are age differences in the strength of functional connectivity within these subsystems, supporting prior evidence that DMN connectivity is particularly vulnerable to age, whereas connectivity involving cognitive control regions is relatively maintained. These results suggest an age difference in the integrated activity among brain networks that can have implications for cognition in older adults. PMID:24294203

Age differences in the intrinsic functional connectivity of default network subsystems.

PubMed

Campbell, Karen L; Grigg, Omer; Saverino, Cristina; Churchill, Nathan; Grady, Cheryl L

2013-01-01

Recent work suggests that the default mode network (DMN) includes two core regions, the ventromedial prefrontal cortex and posterior cingulate cortex (PCC), and several unique subsystems that are functionally distinct. These include a medial temporal lobe (MTL) subsystem, active during remembering and future projection, and a dorsomedial prefrontal cortex (dmPFC) subsystem, active during self-reference. The PCC has been further subdivided into ventral (vPCC) and dorsal (dPCC) regions that are more strongly connected with the DMN and cognitive control networks, respectively. The goal of this study was to examine age differences in resting state functional connectivity within these subsystems. After applying a rigorous procedure to reduce the effects of head motion, we used a multivariate technique to identify both common and unique patterns of functional connectivity in the MTL vs. the dmPFC, and in vPCC vs. dPCC. All four areas had robust functional connectivity with other DMN regions, and each also showed distinct connectivity patterns in both age groups. Young and older adults had equivalent functional connectivity in the MTL subsystem. Older adults showed weaker connectivity in the vPCC and dmPFC subsystems, particularly with other DMN areas, but stronger connectivity than younger adults in the dPCC subsystem, which included areas involved in cognitive control. Our data provide evidence for distinct subsystems involving DMN nodes, which are maintained with age. Nevertheless, there are age differences in the strength of functional connectivity within these subsystems, supporting prior evidence that DMN connectivity is particularly vulnerable to age, whereas connectivity involving cognitive control regions is relatively maintained. These results suggest an age difference in the integrated activity among brain networks that can have implications for cognition in older adults.

Cognitive control during audiovisual working memory engages frontotemporal theta-band interactions.

PubMed

Daume, Jonathan; Graetz, Sebastian; Gruber, Thomas; Engel, Andreas K; Friese, Uwe

2017-10-03

Working memory (WM) maintenance of sensory information has been associated with enhanced cross-frequency coupling between the phase of low frequencies and the amplitude of high frequencies, particularly in medial temporal lobe (MTL) regions. It has been suggested that these WM maintenance processes are controlled by areas of the prefrontal cortex (PFC) via frontotemporal phase synchronisation in low frequency bands. Here, we investigated whether enhanced cognitive control during audiovisual WM as compared to visual WM alone is associated with increased low-frequency phase synchronisation between sensory areas maintaining WM content and areas from PFC. Using magnetoencephalography, we recorded neural oscillatory activity from healthy human participants engaged in an audiovisual delayed-match-to-sample task. We observed that regions from MTL, which showed enhanced theta-beta phase-amplitude coupling (PAC) during the WM delay window, exhibited stronger phase synchronisation within the theta-band (4-7 Hz) to areas from lateral PFC during audiovisual WM as compared to visual WM alone. Moreover, MTL areas also showed enhanced phase synchronisation to temporooccipital areas in the beta-band (20-32 Hz). Our results provide further evidence that a combination of long-range phase synchronisation and local PAC might constitute a mechanism for neuronal communication between distant brain regions and across frequencies during WM maintenance.

Human medial temporal lobe neurons respond preferentially to personally relevant images

PubMed Central

Viskontas, Indre V.; Quiroga, Rodrigo Quian; Fried, Itzhak

2009-01-01

People with whom one is personally acquainted tend to elicit richer and more vivid memories than people with whom one does not have a personal connection. Recent findings from neurons in the human medial temporal lobe (MTL) have shown that individual cells respond selectively and invariantly to representations of famous people [Quian Quiroga R, Reddy L, Kreiman G, Koch C, Fried I (2005) Nature 435(7045):1102–1107]. Observing these cells, we wondered whether photographs of personally relevant individuals, such as family members, might be more likely to generate such responses. To address this issue, we recorded the activity of 2,330 neurons in the human MTL while patients viewed photographs of varying personal relevance: previously unknown faces and landscapes, familiar but not necessarily personally relevant faces and landscapes, and finally, photographs of the patients themselves, their families, and the experimenters. Our findings indicate that personally relevant photographs are indeed more likely to elicit selective responses in MTL neurons than photographs of individuals with whom the patients have had no personal contact. These findings further suggest that relevant stimuli are encoded by a larger proportion of neurons than less relevant stimuli, given that familiar or personally relevant items are linked to a larger variety of experiences and memories of these experiences. PMID:19955441

Domain-specific impairment of source memory following a right posterior medial temporal lobe lesion.

PubMed

Peters, Jan; Koch, Benno; Schwarz, Michael; Daum, Irene

2007-01-01

This single case analysis of memory performance in a patient with an ischemic lesion affecting posterior but not anterior right medial temporal lobe (MTL) indicates that source memory can be disrupted in a domain-specific manner. The patient showed normal recognition memory for gray-scale photos of objects (visual condition) and spoken words (auditory condition). While memory for visual source (texture/color of the background against which pictures appeared) was within the normal range, auditory source memory (male/female speaker voice) was at chance level, a performance pattern significantly different from the control group. This dissociation is consistent with recent fMRI evidence of anterior/posterior MTL dissociations depending upon the nature of source information (visual texture/color vs. auditory speaker voice). The findings are in good agreement with the view of dissociable memory processing by the perirhinal cortex (anterior MTL) and parahippocampal cortex (posterior MTL), depending upon the neocortical input that these regions receive. (c) 2007 Wiley-Liss, Inc.

Saturn's magnetosheath transition layer

NASA Astrophysics Data System (ADS)

Masters, A.; Hasegawa, H.; Phan, T. D.; Badman, S. V.; Fujimoto, M.; Coates, A. J.; Dougherty, M. K.

2012-09-01

The interaction between the solar wind and a magnetised planet produces a cavity around the planet known as a magnetosphere. Although this cavity effectively shields near-planet space from the solar wind, the occurrence of magnetic reconnection at the manetopause boundary of the magnetosphere allows solar wind energy to enter the system. In the case of Earth's magnetosphere a region of reduced plasma pressure and enhanced magnetic pressure can form in the solar wind immediately adjacent to the magnetopause (which also can form around other planetary magnetospheres). This layer is often referred to as the Magnetosheath Transition Layer (MTL), and Earth's MTL responds strongly to magnetopause reconnection. The nature of magnetopause reconnection at Saturn is unclear. We study Saturn's MTL using data taken by the Cassini spacecraft. We examine the reponse of the layer to local magnetised plasma conditions, compare this response to that of Earth's MTL, and assess whether our results are in agreement with current, limited understanding of magnetopause reconnection at Saturn.

Dynamic frontotemporal systems process space and time in working memory

PubMed Central

Adams, Jenna N.; Solbakk, Anne-Kristin; Endestad, Tor; Larsson, Pål G.; Ivanovic, Jugoslav; Meling, Torstein R.; Lin, Jack J.; Knight, Robert T.

2018-01-01

How do we rapidly process incoming streams of information in working memory, a cognitive mechanism central to human behavior? Dominant views of working memory focus on the prefrontal cortex (PFC), but human hippocampal recordings provide a neurophysiological signature distinct from the PFC. Are these regions independent, or do they interact in the service of working memory? We addressed this core issue in behavior by recording directly from frontotemporal sites in humans performing a visuospatial working memory task that operationalizes the types of identity and spatiotemporal information we encounter every day. Theta band oscillations drove bidirectional interactions between the PFC and medial temporal lobe (MTL; including the hippocampus). MTL theta oscillations directed the PFC preferentially during the processing of spatiotemporal information, while PFC theta oscillations directed the MTL for all types of information being processed in working memory. These findings reveal an MTL theta mechanism for processing space and time and a domain-general PFC theta mechanism, providing evidence that rapid, dynamic MTL–PFC interactions underlie working memory for everyday experiences. PMID:29601574

Neural Correlates of Verbal Episodic Memory and Lexical Retrieval in Logopenic Variant Primary Progressive Aphasia.

PubMed

Win, Khaing T; Pluta, John; Yushkevich, Paul; Irwin, David J; McMillan, Corey T; Rascovsky, Katya; Wolk, David; Grossman, Murray

2017-01-01

Objective: Logopenic variant primary progressive aphasia (lvPPA) is commonly associated with Alzheimer's disease (AD) pathology. But lvPPA patients display different cognitive and anatomical profile from the common clinical AD patients, whose verbal episodic memory is primarily affected. Reports of verbal episodic memory difficulty in lvPPA are inconsistent, and we hypothesized that their lexical retrieval impairment contributes to verbal episodic memory performance and is associated with left middle temporal gyrus atrophy. Methods: We evaluated patients with lvPPA ( n = 12) displaying prominent word-finding and repetition difficulties, and a demographically-matched cohort of clinical Alzheimer's disease (AD, n = 26), and healthy seniors ( n = 16). We assessed lexical retrieval with confrontation naming and verbal episodic memory with delayed free recall. Whole-brain regressions related naming and delayed free recall to gray matter atrophy. Medial temporal lobe (MTL) subfields were examined using high in-plane resolution imaging. Results: lvPPA patients had naming and delayed free recall impairments, but intact recognition memory. In lvPPA, delayed free recall was related to naming; both were associated with left middle temporal gyrus atrophy but not MTL atrophy. Despite cerebrospinal fluid evidence consistent with AD pathology, examination of MTL subfields revealed no atrophy in lvPPA. While AD patients displayed impaired delayed free recall, this deficit did not correlate with naming. Regression analyses related delayed free recall deficits in clinical AD patients to MTL subfield atrophy, and naming to left middle temporal gyrus atrophy. Conclusion: Unlike amnestic AD patients, MTL subfields were not affected in lvPPA patients. Verbal episodic memory deficit observed in lvPPA was unlikely to be due to a hippocampal-mediated mechanism but appeared to be due to poor lexical retrieval. Relative sparing of MTL volume and intact recognition memory are consistent with previous reports of hippocampal-sparing variant cases of AD pathology, where neurofibrillary tangles are disproportionately distributed in cortical areas with relative sparing of the hippocampus. This suggests that AD neuropathology in lvPPA may originate in neuronal networks outside of the MTL, which deviates from the typical Braak staging pattern of spreading pathology in clinical AD.

Objects and categories: feature statistics and object processing in the ventral stream.

PubMed

Tyler, Lorraine K; Chiu, Shannon; Zhuang, Jie; Randall, Billi; Devereux, Barry J; Wright, Paul; Clarke, Alex; Taylor, Kirsten I

2013-10-01

Recognizing an object involves more than just visual analyses; its meaning must also be decoded. Extensive research has shown that processing the visual properties of objects relies on a hierarchically organized stream in ventral occipitotemporal cortex, with increasingly more complex visual features being coded from posterior to anterior sites culminating in the perirhinal cortex (PRC) in the anteromedial temporal lobe (aMTL). The neurobiological principles of the conceptual analysis of objects remain more controversial. Much research has focused on two neural regions-the fusiform gyrus and aMTL, both of which show semantic category differences, but of different types. fMRI studies show category differentiation in the fusiform gyrus, based on clusters of semantically similar objects, whereas category-specific deficits, specifically for living things, are associated with damage to the aMTL. These category-specific deficits for living things have been attributed to problems in differentiating between highly similar objects, a process that involves the PRC. To determine whether the PRC and the fusiform gyri contribute to different aspects of an object's meaning, with differentiation between confusable objects in the PRC and categorization based on object similarity in the fusiform, we carried out an fMRI study of object processing based on a feature-based model that characterizes the degree of semantic similarity and difference between objects and object categories. Participants saw 388 objects for which feature statistic information was available and named the objects at the basic level while undergoing fMRI scanning. After controlling for the effects of visual information, we found that feature statistics that capture similarity between objects formed category clusters in fusiform gyri, such that objects with many shared features (typical of living things) were associated with activity in the lateral fusiform gyri whereas objects with fewer shared features (typical of nonliving things) were associated with activity in the medial fusiform gyri. Significantly, a feature statistic reflecting differentiation between highly similar objects, enabling object-specific representations, was associated with bilateral PRC activity. These results confirm that the statistical characteristics of conceptual object features are coded in the ventral stream, supporting a conceptual feature-based hierarchy, and integrating disparate findings of category responses in fusiform gyri and category deficits in aMTL into a unifying neurocognitive framework.

Toward reliable retrieval of functional information of papillary dermis using spatially resolved diffuse reflectance spectroscopy

PubMed Central

Chen, Yu-Wen; Guo, Jun-Yen; Tzeng, Shih-Yu; Chou, Ting-Chun; Lin, Ming-Jen; Huang, Lynn Ling-Huei; Yang, Chao-Chun; Hsu, Chao-Kai; Tseng, Sheng-Hao

2016-01-01

Spatially resolved diffuse reflectance spectroscopy (SRDRS) has been employed to quantify tissue optical properties and its interrogation volume is majorly controlled by the source-to-detector separations (SDSs). To noninvasively quantify properties of dermis, a SRDRS setup that includes SDS shorter than 1 mm is required. It will be demonstrated in this study that Monte Carlo simulations employing the Henyey-Greenstein phase function cannot always precisely predict experimentally measured diffuse reflectance at such short SDSs, and we speculated this could be caused by the non-negligible backward light scattering at short SDSs that cannot be properly modeled by the Henyey-Greenstein phase function. To accurately recover the optical properties and functional information of dermis using SRDRS, we proposed the use of the modified two-layer (MTL) geometry. Monte Carlo simulations and phantom experiment results revealed that the MTL probing geometry was capable of faithfully recovering the optical properties of upper dermis. The capability of the MTL geometry in probing the upper dermis properties was further verified through a swine study, and it was found that the measurement results were reasonably linked to histological findings. Finally, the MTL probe was utilized to study psoriatic lesions. Our results showed that the MTL probe was sensitive to the physiological condition of tissue volumes within the papillary dermis and could be used in studying the physiology of psoriasis. PMID:26977361

Experience-near but not experience-far autobiographical facts depend on the medial temporal lobe for retrieval: Evidence from amnesia

PubMed Central

Grilli, Matthew D.; Verfaellie, Mieke

2015-01-01

This paper addresses the idea that there may be two types of autobiographical facts with distinct cognitive and neural mechanisms: “Experience-near” autobiographical facts, which contain spatiotemporal content derived from personal experience and thus depend on the medial temporal lobe (MTL) for retrieval, and “experience-far” autobiographical facts, which are abstract memories and thus rely on neocortical brain regions involved in retrieval of general semantic memory. To investigate this conceptual model of autobiographical fact knowledge, we analyzed the nature of autobiographical facts that were generated by 8 individuals with MTL amnesia and 12 control participants in a recent study of identity and memory [Grilli, M.D., & Verfaellie, M. (2015). Supporting the self-concept with memory: insight from amnesia. Social Cognitive and Affective Neuroscience, 10, 1684–1692]. Results revealed that MTL amnesic participants generated fewer experience-near autobiographical facts than controls. Experience-far autobiographical fact generation was not impaired in amnesic participants with damage restricted to the MTL, but there was preliminary evidence to suggest that it may be impaired in amnesic participants with damage to the MTL and anterior lateral temporal lobe. These results support a cognitive and neural distinction between experience-near and experience-far autobiographical facts and have implications for understanding the contribution of autobiographical fact knowledge to self-related cognition. PMID:26721761

Experience-near but not experience-far autobiographical facts depend on the medial temporal lobe for retrieval: Evidence from amnesia.

PubMed

Grilli, Matthew D; Verfaellie, Mieke

2016-01-29

This paper addresses the idea that there may be two types of autobiographical facts with distinct cognitive and neural mechanisms: "Experience-near" autobiographical facts, which contain spatiotemporal content derived from personal experience and thus depend on the medial temporal lobe (MTL) for retrieval, and "experience-far" autobiographical facts, which are abstract memories and thus rely on neocortical brain regions involved in retrieval of general semantic memory. To investigate this conceptual model of autobiographical fact knowledge, we analyzed the nature of autobiographical facts that were generated by 8 individuals with MTL amnesia and 12 control participants in a recent study of identity and memory [Grilli, M.D., & Verfaellie, M. (2015). Supporting the self-concept with memory: insight from amnesia. Social Cognitive and Affective Neuroscience, 10, 1684-1692]. Results revealed that MTL amnesic participants generated fewer experience-near autobiographical facts than controls. Experience-far autobiographical fact generation was not impaired in amnesic participants with damage restricted to the MTL, but there was preliminary evidence to suggest that it may be impaired in amnesic participants with damage to the MTL and anterior lateral temporal lobe. These results support a cognitive and neural distinction between experience-near and experience-far autobiographical facts and have implications for understanding the contribution of autobiographical fact knowledge to self-related cognition. Published by Elsevier Ltd.

Toward reliable retrieval of functional information of papillary dermis using spatially resolved diffuse reflectance spectroscopy.

PubMed

Chen, Yu-Wen; Guo, Jun-Yen; Tzeng, Shih-Yu; Chou, Ting-Chun; Lin, Ming-Jen; Huang, Lynn Ling-Huei; Yang, Chao-Chun; Hsu, Chao-Kai; Tseng, Sheng-Hao

2016-02-01

Spatially resolved diffuse reflectance spectroscopy (SRDRS) has been employed to quantify tissue optical properties and its interrogation volume is majorly controlled by the source-to-detector separations (SDSs). To noninvasively quantify properties of dermis, a SRDRS setup that includes SDS shorter than 1 mm is required. It will be demonstrated in this study that Monte Carlo simulations employing the Henyey-Greenstein phase function cannot always precisely predict experimentally measured diffuse reflectance at such short SDSs, and we speculated this could be caused by the non-negligible backward light scattering at short SDSs that cannot be properly modeled by the Henyey-Greenstein phase function. To accurately recover the optical properties and functional information of dermis using SRDRS, we proposed the use of the modified two-layer (MTL) geometry. Monte Carlo simulations and phantom experiment results revealed that the MTL probing geometry was capable of faithfully recovering the optical properties of upper dermis. The capability of the MTL geometry in probing the upper dermis properties was further verified through a swine study, and it was found that the measurement results were reasonably linked to histological findings. Finally, the MTL probe was utilized to study psoriatic lesions. Our results showed that the MTL probe was sensitive to the physiological condition of tissue volumes within the papillary dermis and could be used in studying the physiology of psoriasis.

Greater Working Memory Load Results in Greater Medial Temporal Activity at Retrieval

PubMed Central

Quiroz, Yakeel T.; Hasselmo, Michael E.; Stern, Chantal E.

2009-01-01

Most functional magnetic resonance imaging (fMRI) studies examining working memory (WM) load have focused on the prefrontal cortex (PFC) and have demonstrated increased prefrontal activity with increased load. Here we examined WM load effects in the medial temporal lobe (MTL) using an fMRI Sternberg task with novel complex visual scenes. Trials consisted of 3 sequential events: 1) sample presentation (encoding), 2) delay period (maintenance), and 3) probe period (retrieval). During sample encoding, subjects saw either 2 or 4 pictures consecutively. During retrieval, subjects indicated whether the probe picture matched one of the sample pictures. Results revealed that activity in the left anterior hippocampal formation, bilateral retrosplenial area, and left amygdala was greater at retrieval for trials with larger memory load, whereas activity in the PFC was greater at encoding for trials with larger memory load. There was no load effect during the delay. When encoding, maintenance, and retrieval periods were compared with fixation, activity was present in the hippocampal body/tail and fusiform gyrus bilaterally during encoding and retrieval, but not maintenance. Bilateral dorsolateral prefrontal activity was present during maintenance, but not during encoding or retrieval. The results support models of WM predicting that activity in the MTL should be modulated by WM load. PMID:19224975

Fronto-limbic novelty processing in acute psychosis: disrupted relationship with memory performance and potential implications for delusions

PubMed Central

Schott, Björn H.; Voss, Martin; Wagner, Benjamin; Wüstenberg, Torsten; Düzel, Emrah; Behr, Joachim

2015-01-01

Recent concepts have highlighted the role of the hippocampus and adjacent medial temporal lobe (MTL) in positive symptoms like delusions in schizophrenia. In healthy individuals, the MTL is critically involved in the detection and encoding of novel information. Here, we aimed to investigate whether dysfunctional novelty processing by the MTL might constitute a potential neural mechanism contributing to the pathophysiology of delusions, using functional magnetic resonance imaging (fMRI) in 16 unmedicated patients with paranoid schizophrenia and 20 age-matched healthy controls. All patients experienced positive symptoms at time of participation. Participants performed a visual target detection task with complex scene stimuli in which novel and familiar rare stimuli were presented randomly intermixed with a standard and a target picture. Presentation of novel relative to familiar images was associated with hippocampal activation in both patients and healthy controls, but only healthy controls showed a positive relationship between novelty-related hippocampal activation and recognition memory performance after 24 h. Patients, but not controls, showed a robust neural response in the orbitofrontal cortex (OFC) during presentation of novel stimuli. Functional connectivity analysis in the patients further revealed a novelty-related increase of functional connectivity of both the hippocampus and the OFC with the rostral anterior cingulate cortex (rACC) and the ventral striatum (VS). Notably, delusions correlated positively with the difference of the functional connectivity of the hippocampus vs. the OFC with the rACC. Taken together, our results suggest that alterations of fronto-limbic novelty processing may contribute to the pathophysiology of delusions in patients with acute psychosis. PMID:26082697

The development of the intrinsic functional connectivity of default network subsystems from age 3 to 5.

PubMed

Xiao, Yaqiong; Zhai, Hongchang; Friederici, Angela D; Jia, Fucang

2016-03-01

In recent years, research on human functional brain imaging using resting-state fMRI techniques has been increasingly prevalent. The term "default mode" was proposed to describe a baseline or default state of the brain during rest. Recent studies suggested that the default mode network (DMN) is comprised of two functionally distinct subsystems: a dorsal-medial prefrontal cortex (DMPFC) subsystem involved in self-oriented cognition (i.e., theory of mind) and a medial temporal lobe (MTL) subsystem engaged in memory and scene construction; both subsystems interact with the anterior medial prefrontal cortex (aMPFC) and posterior cingulate (PCC) as the core regions of DMN. The present study explored the development of DMN core regions and these two subsystems in both hemispheres from 3- to 5-year-old children. The analysis of the intrinsic activity showed strong developmental changes in both subsystems, and significant changes were specifically found in MTL subsystem, but not in DMPFC subsystem, implying distinct developmental trajectories for DMN subsystems. We found stronger interactions between the DMPFC and MTL subsystems in 5-year-olds, particularly in the left subsystems that support the development of environmental adaptation and relatively complex mental activities. These results also indicate that there is stronger right hemispheric lateralization at age 3, which then changes as bilateral development gradually increases through to age 5, suggesting in turn the hemispheric dominance in DMN subsystems changing with age. The present results provide primary evidence for the development of DMN subsystems in early life, which might be closely related to the development of social cognition in childhood.

Content-Specific Source Encoding in the Human Medial Temporal Lobe

ERIC Educational Resources Information Center

Awipi, T.; Davachi, L.

2008-01-01

Although the medial temporal lobe (MTL) is known to be essential for episodic encoding, the contributions of individual MTL subregions remain unclear. Data from recognition memory studies have provided evidence that the hippocampus supports relational encoding important for later episodic recollection, whereas the perirhinal cortex has been linked…

Brain activity related to working memory for temporal order and object information.

PubMed

Roberts, Brooke M; Libby, Laura A; Inhoff, Marika C; Ranganath, Charan

2017-06-08

Maintaining items in an appropriate sequence is important for many daily activities; however, remarkably little is known about the neural basis of human temporal working memory. Prior work suggests that the prefrontal cortex (PFC) and medial temporal lobe (MTL), including the hippocampus, play a role in representing information about temporal order. The involvement of these areas in successful temporal working memory, however, is less clear. Additionally, it is unknown whether regions in the PFC and MTL support temporal working memory across different timescales, or at coarse or fine levels of temporal detail. To address these questions, participants were scanned while completing 3 working memory task conditions (Group, Position and Item) that were matched in terms of difficulty and the number of items to be actively maintained. Group and Position trials probed temporal working memory processes, requiring the maintenance of hierarchically organized coarse and fine temporal information, respectively. To isolate activation related to temporal working memory, Group and Position trials were contrasted against Item trials, which required detailed working memory maintenance of visual objects. Results revealed that working memory encoding and maintenance of temporal information relative to visual information was associated with increased activation in dorsolateral PFC (DLPFC), and perirhinal cortex (PRC). In contrast, maintenance of visual details relative to temporal information was characterized by greater activation of parahippocampal cortex (PHC), medial and anterior PFC, and retrosplenial cortex. In the hippocampus, a dissociation along the longitudinal axis was observed such that the anterior hippocampus was more active for working memory encoding and maintenance of visual detail information relative to temporal information, whereas the posterior hippocampus displayed the opposite effect. Posterior parietal cortex was the only region to show sensitivity to temporal working memory across timescales, and was particularly involved in the encoding and maintenance of fine temporal information relative to maintenance of temporal information at more coarse timescales. Collectively, these results highlight the involvement of PFC and MTL in temporal working memory processes, and suggest a dissociation in the type of working memory information represented along the longitudinal axis of the hippocampus. Copyright © 2017 Elsevier B.V. All rights reserved.

Visual integration enhances associative memory equally for young and older adults without reducing hippocampal encoding activation.

PubMed

Memel, Molly; Ryan, Lee

2017-06-01

The ability to remember associations between previously unrelated pieces of information is often impaired in older adults (Naveh-Benjamin, 2000). Unitization, the process of creating a perceptually or semantically integrated representation that includes both items in an associative pair, attenuates age-related associative deficits (Bastin et al., 2013; Ahmad et al., 2015; Zheng et al., 2015). Compared to non-unitized pairs, unitized pairs may rely less on hippocampally-mediated binding associated with recollection, and more on familiarity-based processes mediated by perirhinal cortex (PRC) and parahippocampal cortex (PHC). While unitization of verbal materials improves associative memory in older adults, less is known about the impact of visual integration. The present study determined whether visual integration improves associative memory in older adults by minimizing the need for hippocampal (HC) recruitment and shifting encoding to non-hippocampal medial temporal structures, such as the PRC and PHC. Young and older adults were presented with a series of objects paired with naturalistic scenes while undergoing fMRI scanning, and were later given an associative memory test. Visual integration was varied by presenting the object either next to the scene (Separated condition) or visually integrated within the scene (Combined condition). Visual integration improved associative memory among young and older adults to a similar degree by increasing the hit rate for intact pairs, but without increasing false alarms for recombined pairs, suggesting enhanced recollection rather than increased reliance on familiarity. Also contrary to expectations, visual integration resulted in increased hippocampal activation in both age groups, along with increases in PRC and PHC activation. Activation in all three MTL regions predicted discrimination performance during the Separated condition in young adults, while only a marginal relationship between PRC activation and performance was observed during the Combined condition. Older adults showed less overall activation in MTL regions compared to young adults, and associative memory performance was most strongly predicted by prefrontal, rather than MTL, activation. We suggest that visual integration benefits both young and older adults similarly, and provides a special case of unitization that may be mediated by recollective, rather than familiarity-based encoding processes. Copyright © 2017 Elsevier Ltd. All rights reserved.

It's all coming back to me now: perception and memory in amnesia.

PubMed

Baxter, Mark G

2012-07-12

Medial temporal lobe (MTL) structures may constitute a representational hierarchy, rather than a dedicated system for memory. Barense et al. (2012) show that intact memory for object features can interfere with perception of complex objects in individuals with MTL amnesia. Copyright © 2012 Elsevier Inc. All rights reserved.

Adaptation to Cognitive Context and Item Information in the Medial Temporal Lobes

ERIC Educational Resources Information Center

Diana, Rachel A.; Yonelinas, Andrew P.; Ranganath, Charan

2012-01-01

The medial temporal lobes (MTL) play an essential role in episodic memory, and accumulating evidence indicates that two MTL subregions--the perirhinal (PRc) and parahippocampal (PHc) cortices--might have different functions. According to the binding of item and context theory ( [16] and [21]), PRc is involved in processing item information, the…

Working Memory, Long-Term Memory, and Medial Temporal Lobe Function

ERIC Educational Resources Information Center

Jeneson, Annette; Squire, Larry R.

2012-01-01

Early studies of memory-impaired patients with medial temporal lobe (MTL) damage led to the view that the hippocampus and related MTL structures are involved in the formation of long-term memory and that immediate memory and working memory are independent of these structures. This traditional idea has recently been revisited. Impaired performance…

Episodic memory in aspects of large-scale brain networks

PubMed Central

Jeong, Woorim; Chung, Chun Kee; Kim, June Sic

2015-01-01

Understanding human episodic memory in aspects of large-scale brain networks has become one of the central themes in neuroscience over the last decade. Traditionally, episodic memory was regarded as mostly relying on medial temporal lobe (MTL) structures. However, recent studies have suggested involvement of more widely distributed cortical network and the importance of its interactive roles in the memory process. Both direct and indirect neuro-modulations of the memory network have been tried in experimental treatments of memory disorders. In this review, we focus on the functional organization of the MTL and other neocortical areas in episodic memory. Task-related neuroimaging studies together with lesion studies suggested that specific sub-regions of the MTL are responsible for specific components of memory. However, recent studies have emphasized that connectivity within MTL structures and even their network dynamics with other cortical areas are essential in the memory process. Resting-state functional network studies also have revealed that memory function is subserved by not only the MTL system but also a distributed network, particularly the default-mode network (DMN). Furthermore, researchers have begun to investigate memory networks throughout the entire brain not restricted to the specific resting-state network (RSN). Altered patterns of functional connectivity (FC) among distributed brain regions were observed in patients with memory impairments. Recently, studies have shown that brain stimulation may impact memory through modulating functional networks, carrying future implications of a novel interventional therapy for memory impairment. PMID:26321939

Using future thinking to reduce temporal discounting: Under what circumstances are the medial temporal lobes critical?

PubMed

Palombo, D J; Keane, M M; Verfaellie, M

2016-08-01

The capacity to envision the future plays an important role in many aspects of cognition, including our ability to make optimal, adaptive choices. Past work has shown that the medial temporal lobe (MTL) is necessary for decisions that draw on episodic future thinking. By contrast, little is known about the role of the MTL in decisions that draw on semantic future thinking. Accordingly, the present study investigated whether the MTL contributes to one form of decision making, namely intertemporal choice, when such decisions depend on semantic consideration of the future. In an intertemporal choice task, participants must select either a smaller amount of money that is available in the present or a larger amount of money that would be available at a future date. Amnesic individuals with MTL damage and healthy control participants performed such a task in which, prior to making a choice, they engaged in a semantic generation exercise, wherein they generated items that they would purchase with the future reward. In experiment 1, we found that, relative to a baseline condition involving standard intertemporal choice, healthy individuals were more inclined to select a larger, later reward over a smaller, present reward after engaging in semantic future thinking. By contrast, amnesic participants were paradoxically less inclined to wait for a future reward following semantic future thinking. This finding suggests that amnesics may have had difficulty "tagging" the generated item(s) as belonging to the future. Critically, experiment 2 showed that when the generated items were presented alongside the intertemporal choices, both controls and amnesic participants shifted to more patient choices. These findings suggest that the MTL is not needed for making optimal decisions that draw on semantic future thinking as long as scaffolding is provided to support accurate time tagging. Together, these findings stand to better clarify the role of the MTL in decision making. Published by Elsevier Ltd.

Induction of Metallothionein Expression After Exposure to Conventional Cigarette Smoke but Not Electronic Cigarette (ECIG)-Generated Aerosol in Caenorhabditis elegans

PubMed Central

Cobb, Eric; Hall, Julie; Palazzolo, Dominic L.

2018-01-01

Aim: With the invention of electronic cigarettes (ECIG), many questions have been raised regarding their safety as an alternative to smoking conventional cigarettes. Conventional cigarette smoke contains a variety of toxicants including heavy metals. However, ECIG-generated aerosol contains only trace amounts of metals, adding to the argument for it being a safer alternative. In response to heavy metal exposure, metallothioneins are induced in cells to help store the metal, detoxify the body, and are also known responders to oxidative stress. In an attempt to add to the evaluation of the safety of ECIGs, metallothionein expression was quantified using the nematode Caenorhabditis elegans as an assessment of stress induced cellular damage caused by exposure. Methods: Adult nematodes were exposed to either ECIG aerosol or conventional cigarette smoke at doses of 15, 30, and 45 puffs, the equivalent of one, two, and three cigarettes, respectively. Movement, survival, and stress-induced sleep were assessed for up to 24 h after exposure. Relative expression levels for mtl-1 and mtl-2, C. elegans metallothionein genes, were analyzed after 1, 5, and 24 h post exposure using quantitative RT-PCR. Results: Nematodes exposed to conventional cigarette smoke underwent stress-induced sleep in a dose dependent manner with animals recovering to values within the range of air control after 5 h post exposure. Those exposed to ECIG aerosol did not undergo stress-induced sleep and were indistinguishable from controls. The expression of mtl-1 increased in a dose and time dependent manner in C. elegans exposed to conventional cigarette smoke, with a maximum expression observed at 5 h post exposure of 45 puffs. No induction of mtl-2 was observed in any animals. Additionally, ECIG aerosol did not induce expression of mtl-1 and mtl-2 at levels different than those of untreated. Conclusion: ECIG aerosol failed to induce a stress response in C. elegans. In contrast, conventional cigarette smoke induced the production of mtl-1 in a manner that correlates with the induction of stress-induced sleep suggesting a stress response to damage. The lack of cellular stress response to ECIG aerosol suggests it may be a safer alternative to conventional cigarettes. PMID:29740339

Spatial and temporal episodic memory retrieval recruit dissociable functional networks in the human brain.

PubMed

Ekstrom, Arne D; Bookheimer, Susan Y

2007-10-01

Imaging, electrophysiological studies, and lesion work have shown that the medial temporal lobe (MTL) is important for episodic memory; however, it is unclear whether different MTL regions support the spatial, temporal, and item elements of episodic memory. In this study we used fMRI to examine retrieval performance emphasizing different aspects of episodic memory in the context of a spatial navigation paradigm. Subjects played a taxi-driver game ("yellowcab"), in which they freely searched for passengers and delivered them to specific landmark stores. Subjects then underwent fMRI scanning as they retrieved landmarks, spatial, and temporal associations from their navigational experience in three separate runs. Consistent with previous findings on item memory, perirhinal cortex activated most strongly during landmark retrieval compared with spatial or temporal source information retrieval. Both hippocampus and parahippocampal cortex activated significantly during retrieval of landmarks, spatial associations, and temporal order. We found, however, a significant dissociation between hippocampal and parahippocampal cortex activations, with spatial retrieval leading to greater parahippocampal activation compared with hippocampus and temporal order retrieval leading to greater hippocampal activation compared with parahippocampal cortex. Our results, coupled with previous findings, demonstrate that the hippocampus and parahippocampal cortex are preferentially recruited during temporal order and spatial association retrieval--key components of episodic "source" memory.

Spatial and Temporal Episodic Memory Retrieval Recruit Dissociable Functional Networks in the Human Brain

ERIC Educational Resources Information Center

Ekstrom, Arne D.; Bookheimer, Susan Y.

2007-01-01

Imaging, electrophysiological studies, and lesion work have shown that the medial temporal lobe (MTL) is important for episodic memory; however, it is unclear whether different MTL regions support the spatial, temporal, and item elements of episodic memory. In this study we used fMRI to examine retrieval performance emphasizing different aspects…

Material-Specific Lateralization of Working Memory in the Medial Temporal Lobe

ERIC Educational Resources Information Center

Wagner, Dylan D.; Sziklas, Viviane; Garver, Krista E.; Jones-Gotman, Marilyn

2009-01-01

Mnemonic deficits in patients with medial temporal lobe (MTL) damage arising from temporal lobe epilepsy (TLE) are traditionally constrained to long-term episodic memory, sparing short-term and working memory (WM). This view of WM as being independent of MTL structures has recently been challenged by a small number of patient and neuroimaging…

The Relevance of the Nature of Learned Associations for the Differentiation of Human Memory Systems

ERIC Educational Resources Information Center

Rose, Michael; Haider, Hilde; Weiller, Cornelius; Buchel, Christian

2004-01-01

In a previous functional magnetic resonance imaging (fMRI) study we demonstrated an involvement of the medial temporal lobe (MTL) during an implicit learning task. We concluded that the MTL was engaged because of the complex contingencies that were implicitly learned. In addition, the basal ganglia demonstrated effects of a paralleled…

Neural activation patterns of successful episodic encoding: Reorganization during childhood, maintenance in old age.

PubMed

Shing, Yee Lee; Brehmer, Yvonne; Heekeren, Hauke R; Bäckman, Lars; Lindenberger, Ulman

2016-08-01

The two-component framework of episodic memory (EM) development posits that the contributions of medial temporal lobe (MTL) and prefrontal cortex (PFC) to successful encoding differ across the lifespan. To test the framework's hypotheses, we compared subsequent memory effects (SME) of 10-12 year-old children, younger adults, and older adults using functional magnetic resonance imaging (fMRI). Memory was probed by cued recall, and SME were defined as regional activation differences during encoding between subsequently correctly recalled versus omitted items. In MTL areas, children's SME did not differ in magnitude from those of younger and older adults. In contrast, children's SME in PFC were weaker than the corresponding SME in younger and older adults, in line with the hypothesis that PFC contributes less to successful encoding in childhood. Differences in SME between younger and older adults were negligible. The present results suggest that, among individuals with high memory functioning, the neural circuitry contributing to successful episodic encoding is reorganized from middle childhood to adulthood. Successful episodic encoding in later adulthood, however, is characterized by the ability to maintain the activation patterns that emerged in young adulthood. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

True and False Memories, Parietal Cortex, and Confidence Judgments

ERIC Educational Resources Information Center

Urgolites, Zhisen J.; Smith, Christine N.; Squire, Larry R.

2015-01-01

Recent studies have asked whether activity in the medial temporal lobe (MTL) and the neocortex can distinguish true memory from false memory. A frequent complication has been that the confidence associated with correct memory judgments (true memory) is typically higher than the confidence associated with incorrect memory judgments (false memory).…

Telling true from false: cannabis users show increased susceptibility to false memories.

PubMed

Riba, J; Valle, M; Sampedro, F; Rodríguez-Pujadas, A; Martínez-Horta, S; Kulisevsky, J; Rodríguez-Fornells, A

2015-06-01

Previous studies on the neurocognitive impact of cannabis use have found working and declarative memory deficits that tend to normalize with abstinence. An unexplored aspect of cognitive function in chronic cannabis users is the ability to distinguish between veridical and illusory memories, a crucial aspect of reality monitoring that relies on adequate memory function and cognitive control. Using functional magnetic resonance imaging, we show that abstinent cannabis users have an increased susceptibility to false memories, failing to identify lure stimuli as events that never occurred. In addition to impaired performance, cannabis users display reduced activation in areas associated with memory processing within the lateral and medial temporal lobe (MTL), and in parietal and frontal brain regions involved in attention and performance monitoring. Furthermore, cannabis consumption was inversely correlated with MTL activity, suggesting that the drug is especially detrimental to the episodic aspects of memory. These findings indicate that cannabis users have an increased susceptibility to memory distortions even when abstinent and drug-free, suggesting a long-lasting compromise of memory and cognitive control mechanisms involved in reality monitoring.

Default Mode Network Subsystems are Differentially Disrupted in Posttraumatic Stress Disorder

PubMed Central

Miller, Danielle R.; Hayes, Scott M.; Hayes, Jasmeet P.; Spielberg, Jeffrey M.; Lafleche, Ginette; Verfaellie, Mieke

2017-01-01

Background Posttraumatic stress disorder (PTSD) is a psychiatric disorder characterized by debilitating re-experiencing, avoidance, and hyperarousal symptoms following trauma exposure. Recent evidence suggests that individuals with PTSD show disrupted functional connectivity in the default mode network, an intrinsic network that consists of a midline core, a medial temporal lobe (MTL) subsystem, and a dorsomedial prefrontal cortex (dMPFC) subsystem. The present study examined whether functional connectivity in these subsystems is differentially disrupted in PTSD. Methods Sixty-nine returning war Veterans with PTSD and 44 trauma-exposed Veterans without PTSD underwent resting state functional MRI (rs-fMRI). To examine functional connectivity, seeds were placed in the core hubs of the default mode network, namely the posterior cingulate cortex (PCC) and anterior medial PFC (aMPFC), and in each subsystem. Results Compared to controls, individuals with PTSD had reduced functional connectivity between the PCC and the hippocampus, a region of the MTL subsystem. Groups did not differ in connectivity between the PCC and dMPFC subsystem or between the aMPFC and any region within either subsystem. In the PTSD group, connectivity between the PCC and hippocampus was negatively associated with avoidance/numbing symptoms. Examination of the MTL and dMPFC subsystems revealed reduced anticorrelation between the ventromedial PFC (vMPFC) seed of the MTL subsystem and the dorsal anterior cingulate cortex in the PTSD group. Conclusions Our results suggest that selective alterations in functional connectivity in the MTL subsystem of the default mode network in PTSD may be an important factor in PTSD pathology and symptomatology. PMID:28435932

Default Mode Network Subsystems are Differentially Disrupted in Posttraumatic Stress Disorder.

PubMed

Miller, Danielle R; Hayes, Scott M; Hayes, Jasmeet P; Spielberg, Jeffrey M; Lafleche, Ginette; Verfaellie, Mieke

2017-05-01

Posttraumatic stress disorder (PTSD) is a psychiatric disorder characterized by debilitating re-experiencing, avoidance, and hyperarousal symptoms following trauma exposure. Recent evidence suggests that individuals with PTSD show disrupted functional connectivity in the default mode network, an intrinsic network that consists of a midline core, a medial temporal lobe (MTL) subsystem, and a dorsomedial prefrontal cortex (dMPFC) subsystem. The present study examined whether functional connectivity in these subsystems is differentially disrupted in PTSD. Sixty-nine returning war Veterans with PTSD and 44 trauma-exposed Veterans without PTSD underwent resting state functional MRI (rs-fMRI). To examine functional connectivity, seeds were placed in the core hubs of the default mode network, namely the posterior cingulate cortex (PCC) and anterior medial PFC (aMPFC), and in each subsystem. Compared to controls, individuals with PTSD had reduced functional connectivity between the PCC and the hippocampus, a region of the MTL subsystem. Groups did not differ in connectivity between the PCC and dMPFC subsystem or between the aMPFC and any region within either subsystem. In the PTSD group, connectivity between the PCC and hippocampus was negatively associated with avoidance/numbing symptoms. Examination of the MTL and dMPFC subsystems revealed reduced anticorrelation between the ventromedial PFC (vMPFC) seed of the MTL subsystem and the dorsal anterior cingulate cortex in the PTSD group. Our results suggest that selective alterations in functional connectivity in the MTL subsystem of the default mode network in PTSD may be an important factor in PTSD pathology and symptomatology.

Magnetic Resonance Imaging and Anatomical Correlation of Human Temporal Lobe Landmarks, in 3D Euclidean Space: A Study of Control and Alzheimer's Disease Subjects.

PubMed

Delgado-González, José-Carlos; Florensa-Vila, José; Mansilla-Legorburo, Francisco; Insausti, Ricardo; Artacho-Pérula, Emilio

2017-01-01

The medial temporal lobe (MTL), and in particular the hippocampal formation, is essential in the processing and consolidation of declarative memory. The 3D environment of the anatomical structures contained in the MTL is an important issue. Our aim was to explore the spatial relationship of the anatomical structures of the MTL and changes in aging and/or Alzheimer's disease (AD). MTL anatomical landmarks are identified and registered to create a 3D network. The brain network is quantitatively described as a plane, rostrocaudally-oriented, and presenting Euclidean/real distances. Correspondence between 1.5T RM, 3T RM, and histological sections were assessed to determine the most important recognizable changes in AD, based on statistical significance. In both 1.5T and 3T RM images and histology, inter-rater reliability was high. Sex and hemisphere had no influence on network pattern. Minor changes were found in relation to aging. Distances from the temporal pole to the dentate gyrus showed the most significant differences when comparing control and AD groups. The best discriminative distance between control and AD cases was found in the temporal pole/dentate gyrus rostrocaudal length in histological sections. Moreover, more distances between landmarks were required to obtain 100% discrimination between control (divided into <65 years or >65 years) and AD cases. Changes in the distance between MTL anatomical landmarks can successfully be detected by using measurements of 3D network patterns in control and AD cases.

Memory for Faces Dissociates from Memory for Location Following Anterior Temporal Lobectomy

ERIC Educational Resources Information Center

Chiaravalloti, Nancy D.; Glosser, Guila

2004-01-01

It has been suggested that the right and left mesial temporal lobes are specialized for processing different types of information for long-term memory (LTM). Although findings have been consistent in regard to the dominant role of the left mesial temporal lobe (MTL) in verbal memory, the role of the right MTL in non-verbal memory remains…

Ventral Fronto-Temporal Pathway Supporting Cognitive Control of Episodic Memory Retrieval

PubMed Central

Barredo, Jennifer; Öztekin, Ilke; Badre, David

2015-01-01

Achieving our goals often requires guiding access to relevant information from memory. Such goal-directed retrieval requires interactions between systems supporting cognitive control, including ventrolateral prefrontal cortex (VLPFC), and those supporting declarative memory, such as the medial temporal lobes (MTL). However, the pathways by which VLPFC interacts with MTL during retrieval are underspecified. Prior neuroanatomical evidence suggests that a polysynaptic ventral fronto-temporal pathway may support VLPFC–MTL interactions. To test this hypothesis, human participants were scanned using fMRI during performance of a source-monitoring task. The strength of source information was varied via repetition during encoding. Single encoding events should produce a weaker memory trace, thus recovering source information about these items should demand greater cognitive control. Results demonstrated that cortical targets along the ventral path—anterior VLPFC, temporal pole, anterior parahippocampus, and hippocampus—exhibited increases in univariate BOLD response correlated with increases in controlled retrieval demand, independent of factors related to response selection. Further, a functional connectivity analysis indicated that these regions functionally couple and are distinguishable from a dorsal pathway related to response selection demands. These data support a ventral retrieval pathway linking PFC and MTL. PMID:24177990

Retinal thinning is uniquely associated with medial temporal lobe atrophy in neurologically normal older adults

PubMed Central

Casaletto, Kaitlin B.; Ward, Michael E.; Baker, Nicholas S.; Bettcher, Brianne M.; Gelfand, Jeffrey M.; Li, Yaqiao; Chen, Robert; Dutt, Shubir; Miller, Bruce; Kramer, Joel H.; Green, Ari J.

2017-01-01

Given the converging pathologic and epidemiologic data indicating a relationship between retinal integrity and neurodegeneration, including Alzheimer’s disease (AD), we aimed to determine if retinal structure correlates with medial temporal lobe (MTL) structure and function in neurologically normal older adults. Spectral-domain optical coherence tomography, verbal and visual memory testing, and 3T-magnetic resonance imaging of the brain were performed in 79 neurologically normal adults enrolled in a healthy aging cohort study. Retinal nerve fiber thinning and reduced total macular and macular ganglion cell volumes were each associated with smaller MTL volumes (ps < 0.04). Notably, these markers of retinal structure were not associated with primary motor cortex or basal ganglia volumes (regions relatively unaffected in AD) (ps > 0.70), or frontal, precuneus, or temporoparietal volumes (regions affected in later AD Braak staging ps > 0.20). Retinal structure was not significantly associated with verbal or visual memory consolidation performances (ps > 0.14). Retinal structure was associated with MTL volumes, but not memory performances, in otherwise neurologically normal older adults. Given that MTL atrophy is a neuropathological hallmark of AD, retinal integrity may be an early marker of ongoing AD-related brain health. PMID:28068565

Dominance of objects over context in a mediotemporal lobe model of schizophrenia.

PubMed

Talamini, Lucia M; Meeter, Martijn

2009-08-04

A large body of evidence suggests impaired context processing in schizophrenia. Here we propose that this impairment arises from defective integration of mediotemporal 'what' and 'where' routes, carrying object and spatial information to the hippocampus. We have previously shown, in a mediotemporal lobe (MTL) model, that the abnormal connectivity between MTL regions observed in schizophrenia can explain the episodic memory deficits associated with the disorder. Here we show that the same neuropathology leads to several context processing deficits observed in patients with schizophrenia: 1) failure to choose subordinate stimuli over dominant ones when the former fit the context, 2) decreased contextual constraints in memory retrieval, as reflected in increased false alarm rates and 3) impaired retrieval of contextual information in source monitoring. Model analyses show that these deficits occur because the 'schizophrenic MTL' forms fragmented episodic representations, in which objects are overrepresented at the expense of spatial contextual information. These findings highlight the importance of MTL neuropathology in schizophrenia, demonstrating that it may underlie a broad spectrum of deficits, including context processing and memory impairments. It is argued that these processing deficits may contribute to central schizophrenia symptoms such as contextually inappropriate behavior, associative abnormalities, conversational drift, concreteness and delusions.

The Medial Temporal Lobe and Recognition Memory

PubMed Central

Eichenbaum, H.; Yonelinas, A.R.; Ranganath, C.

2007-01-01

The ability to recognize a previously experienced stimulus is supported by two processes: recollection of the stimulus in the context of other information associated with the experience, and a sense of familiarity with the features of the stimulus. Although familiarity and recollection are functionally distinct, there is considerable debate about how these kinds of memory are supported by regions in the medial temporal lobes (MTL). Here, we review evidence for the distinction between recollection and familiarity and then consider the evidence regarding the neural mechanisms of these processes. Evidence from neuropsychological, neuroimaging, and neurophysiological studies of humans, monkeys, and rats indicates that different subregions of the MTL make distinct contributions to recollection and familiarity. The data suggest that the hippocampus is critical for recollection but not familiarity. The parahippocampal cortex also contributes to recollection, possibly via the representation and retrieval of contextual (especially spatial) information, whereas perirhinal cortex contributes to and is necessary for familiarity-based recognition. The findings are consistent with an anatomically guided hypothesis about the functional organization of the MTL and suggest mechanisms by which the anatomical components of the MTL interact to support of the phenomenology of recollection and familiarity. PMID:17417939

Neural Correlate of Anterograde Amnesia in Wernicke-Korsakoff Syndrome.

PubMed

Nahum, Louis; Pignat, Jean-Michel; Bouzerda-Wahlen, Aurélie; Gabriel, Damien; Liverani, Maria Chiara; Lazeyras, François; Ptak, Radek; Richiardi, Jonas; Haller, Sven; Thorens, Gabriel; Zullino, Daniele F; Guggisberg, Adrian G; Schnider, Armin

2015-09-01

The neural correlate of anterograde amnesia in Wernicke-Korsakoff syndrome (WKS) is still debated. While the capacity to learn new information has been associated with integrity of the medial temporal lobe (MTL), previous studies indicated that the WKS is associated with diencephalic lesions, mainly in the mammillary bodies and anterior or dorsomedial thalamic nuclei. The present study tested the hypothesis that amnesia in WKS is associated with a disrupted neural circuit between diencephalic and hippocampal structures. High-density evoked potentials were recorded in four severely amnesic patients with chronic WKS, in five patients with chronic alcoholism without WKS, and in ten age matched controls. Participants performed a continuous recognition task of pictures previously shown to induce a left medial temporal lobe dependent positive potential between 250 and 350 ms. In addition, the integrity of the fornix was assessed using diffusion tensor imaging (DTI). WKS, but not alcoholic patients without WKS, showed absence of the early, left MTL dependent positive potential following immediate picture repetitions. DTI indicated disruption of the fornix, which connects diencephalic and hippocampal structures. The findings support an interpretation of anterograde amnesia in WKS as a consequence of a disconnection between diencephalic and MTL structures with deficient contribution of the MTL to rapid consolidation.

Emotional and cognitive stimuli differentially engage the default network during inductive reasoning

PubMed Central

Deckersbach, Thilo; Carlson, Lindsay E.; Beucke, Jan C.; Dougherty, Darin D.

2012-01-01

The brain’s default network (DN) is comprised of several cortical regions demonstrating robust intrinsic connectivity at rest. The authors sought to examine the differential effects of emotional reasoning and reasoning under certainty upon the DN through the employment of an event-related fMRI design in healthy participants. Participants were presented with syllogistic arguments which were organized into a 2 × 2 factorial design in which the first factor was emotional salience and the second factor was certainty/uncertainty. We demonstrate that regions of the DN were activated both during reasoning that is emotionally salient and during reasoning which is more certain, suggesting that these processes are neurally instantiated on a network level. In addition, we present evidence that emotional reasoning preferentially activates the dorsomedial (dMPFC) subsystem of the DN, whereas reasoning in the context of certainty activates areas specific to the DN’s medial temporal (MTL) subsystem. We postulate that emotional reasoning mobilizes the dMPFC subsystem of the DN because this type of reasoning relies upon the recruitment of introspective and self-relevant data such as personal bias and temperament. In contrast, activation of the MTL subsystem during certainty argues that this form of reasoning involves the recruitment of mnemonic and semantic associations to derive conclusions. PMID:21296864

Emotional and cognitive stimuli differentially engage the default network during inductive reasoning.

PubMed

Eldaief, Mark C; Deckersbach, Thilo; Carlson, Lindsay E; Beucke, Jan C; Dougherty, Darin D

2012-04-01

The brain's default network (DN) is comprised of several cortical regions demonstrating robust intrinsic connectivity at rest. The authors sought to examine the differential effects of emotional reasoning and reasoning under certainty upon the DN through the employment of an event-related fMRI design in healthy participants. Participants were presented with syllogistic arguments which were organized into a 2 × 2 factorial design in which the first factor was emotional salience and the second factor was certainty/uncertainty. We demonstrate that regions of the DN were activated both during reasoning that is emotionally salient and during reasoning which is more certain, suggesting that these processes are neurally instantiated on a network level. In addition, we present evidence that emotional reasoning preferentially activates the dorsomedial (dMPFC) subsystem of the DN, whereas reasoning in the context of certainty activates areas specific to the DN's medial temporal (MTL) subsystem. We postulate that emotional reasoning mobilizes the dMPFC subsystem of the DN because this type of reasoning relies upon the recruitment of introspective and self-relevant data such as personal bias and temperament. In contrast, activation of the MTL subsystem during certainty argues that this form of reasoning involves the recruitment of mnemonic and semantic associations to derive conclusions.

Neural Correlates of Confidence during Item Recognition and Source Memory Retrieval: Evidence for Both Dual-Process and Strength Memory Theories

ERIC Educational Resources Information Center

Hayes, Scott M.; Buchler, Norbou; Stokes, Jared; Kragel, James; Cabeza, Roberto

2011-01-01

Although the medial-temporal lobes (MTL), PFC, and parietal cortex are considered primary nodes in the episodic memory network, there is much debate regarding the contributions of MTL, PFC, and parietal subregions to recollection versus familiarity (dual-process theory) and the feasibility of accounts on the basis of a single memory strength…

A Pencil Rescues Impaired Performance on a Visual Discrimination Task in Patients with Medial Temporal Lobe Lesions

ERIC Educational Resources Information Center

Knutson, Ashley R.; Hopkins, Ramona O.; Squire, Larry R.

2013-01-01

We tested proposals that medial temporal lobe (MTL) structures support not just memory but certain kinds of visual perception as well. Patients with hippocampal lesions or larger MTL lesions attempted to identify the unique object among twin pairs of objects that had a high degree of feature overlap. Patients were markedly impaired under the more…

Going beyond LTM in the MTL: A Synthesis of Neuropsychological and Neuroimaging Findings on the Role of the Medial Temporal Lobe in Memory and Perception

ERIC Educational Resources Information Center

Graham, Kim S.; Barense, Morgan D.; Lee, Andy C. H.

2010-01-01

Studies in rats and non-human primates suggest that medial temporal lobe (MTL) structures play a role in perceptual processing, with the hippocampus necessary for spatial discrimination, and the perirhinal cortex for object discrimination. Until recently, there was little convergent evidence for analogous functional specialisation in humans, or…

Decreased Parahippocampal Activity in Associative Priming: Evidence from an Event-Related fMRI Study

ERIC Educational Resources Information Center

Yang, Jiongjiong; Meckingler, Axel; Xu, Mingwei; Zhao, Yanbing; Weng, Xuchu

2008-01-01

In recent years, there has been intense debate on the neural basis of associative priming, particularly on the role of the medial temporal lobe (MTL) in retrieving associative information without awareness. In this study, event-related fMRI was used while healthy subjects performed a perceptual identification task on briefly presented unrelated…

Phenotypic regional fMRI activation patterns during memory encoding in MCI and AD

PubMed Central

Browndyke, Jeffrey N.; Giovanello, Kelly; Petrella, Jeffrey; Hayden, Kathleen; Chiba-Falek, Ornit; Tucker, Karen A.; Burke, James R.; Welsh-Bohmer, Kathleen A.

2014-01-01

Background Reliable blood-oxygen-level-dependent (BOLD) fMRI phenotypic biomarkers of Alzheimer's disease (AD) or mild cognitive impairment (MCI) are likely to emerge only from a systematic, quantitative, and aggregate examination of the functional neuroimaging research literature. Methods A series of random-effects, activation likelihood estimation (ALE) meta-analyses were conducted on studies of episodic memory encoding operations in AD and MCI samples relative to normal controls. ALE analyses were based upon a thorough literature search for all task-based functional neuroimaging studies in AD and MCI published up to January 2010. Analyses covered 16 fMRI studies, which yielded 144 distinct foci for ALE meta-analysis. Results ALE results indicated several regional task-based BOLD consistencies in MCI and AD patients relative to normal controls across the aggregate BOLD functional neuroimaging research literature. Patients with AD and those at significant risk (MCI) showed statistically significant consistent activation differences during episodic memory encoding in the medial temporal lobe (MTL), specifically parahippocampal gyrus, as well superior frontal gyrus, precuneus, and cuneus, relative to normal controls. Conclusions ALE consistencies broadly support the presence of frontal compensatory activity, MTL activity alteration, and posterior midline “default mode” hyperactivation during episodic memory encoding attempts in the diseased or prospective pre-disease condition. Taken together these robust commonalities may form the foundation for a task-based fMRI phenotype of memory encoding in AD. PMID:22841497

Hormetic effect of methylmercury on Caenorhabditis elegans

DOE Office of Scientific and Technical Information (OSTI.GOV)

Helmcke, Kirsten J., E-mail: Kirsten.J.Helmcke@gmail.com; Aschner, Michael, E-mail: Michael.Aschner@vanderbilt.ed

2010-10-15

Research has demonstrated the toxic effects of methylmercury (MeHg), yet molecular mechanisms underlying its toxicity are not completely understood. Caenorhabditis elegans (C. elegans) offers a unique biological model to explore mechanisms of MeHg toxicity given many advantages associated with its ease of use and genetic power. Since our previous work indicated neurotoxic resistance of C. elegans to MeHg, the present study was designed to examine molecular mechanisms associated with this resistance. We hypothesized MeHg would induce expression of gst, hsp or mtl in vivo since glutathione (GSH), heat shock proteins (HSPs), and metallothioneins (MTs) have shown involvement in MeHg toxicity.more » Our studies demonstrated a modest, but significant increase in fluorescence in gst-4::GFP and mtl-1::GFP strains at an acute, low L1 MeHg exposure, whereas chronic L4 MeHg exposure induced expression of gst-4::GFP and hsp-4::GFP. Knockout gst-4 animals showed no alterations in lethality sensitivity compared to wildtype animals whereas mtl knockouts displayed increased sensitivity to MeHg exposure. GSH levels were increased by acute MeHg treatment and depleted with chronic exposure. We also demonstrate that MeHg induces hormesis, a phenotype whereby a sublethal exposure to MeHg rendered C. elegans resistant to subsequent exposure to the organometal. The involvement of gst-4, hsp-4, mtl-1, and mtl-2 in hormesis was examined. An increase in gst-4::GFP expression after a low-dose acute exposure to MeHg indicated that gst-4 may be involved in this response. Our results implicate GSH, HSPs, and MTs in protecting C. elegans from MeHg toxicity and show a potential role of gst-4 in MeHg-induced hormesis.« less

Impact of explained v. unexplained front-of-package nutrition labels on parent and child food choices: a randomized trial.

PubMed

Graham, Dan J; Lucas-Thompson, Rachel G; Mueller, Megan P; Jaeb, Melanie; Harnack, Lisa

2017-04-01

The present study investigated whether parent/child pairs would select more healthful foods when: (i) products were labelled with front-of-package (FOP) nutrition labels relative to packages without labels; (ii) products were labelled with colour-coded Multiple Traffic Light (MTL) FOP labels relative to monochromatic Facts up Front (FuF) FOP labels; and (iii) FOP labels were explained via in-aisle signage v. unexplained. Participants were randomly assigned to one of five conditions: (i) FuF labels with in-aisle signs explaining the labels; (ii) FuF labels, no signage; (iii) MTL labels with in-aisle signage; (iv) MTL labels, no signage; (v) control group, no labels/signage. Saturated fat, sodium, sugar and energy (calorie) content were compared across conditions. The study took place in a laboratory grocery aisle. Parent/child pairs (n 153) completed the study. Results did not support the hypothesis that MTL labels would lead to more healthful choices than FuF labels. The presence of FOP labels did little to improve the healthfulness of selected foods, with few exceptions (participants with v. without access to FOP labels selected lower-calorie cereals, participants with access to both FOP labels and in-aisle explanatory signage selected products with less saturated fat v. participants without explanatory signage). Neither MTL nor FuF FOP labels led to food choices with significantly lower saturated fat, sodium or sugar. In-aisle signs explaining the FOP labels were somewhat helpful to consumers in making more healthful dietary decisions. New FOP labelling programmes could benefit from campaigns to increase consumer awareness and understanding of the labels.

Genetic Risk for Age-Related Cognitive Impairment Does Not Predict Cognitive Performance in Middle Age.

PubMed

Korthauer, Laura E; Awe, Elizabeth; Frahmand, Marijam; Driscoll, Ira

2018-05-26

Alzheimer's disease (AD) is characterized by memory loss and executive dysfunction, which correspond to structural changes to the medial temporal lobes (MTL) and prefrontal cortex (PFC), respectively. Given the overlap in cognitive deficits between healthy aging and the earliest stages of AD, early detection of AD remains a challenge. The goal of the present study was to study MTL- and PFC-dependent cognitive functioning in middle-aged individuals at genetic risk for AD or cognitive impairment who do not currently manifest any clinical symptoms. Participants (N = 150; aged 40-60 years) underwent genotyping of 47 single nucleotide polymorphisms (SNPs) in six genes previously associated with memory or executive functioning: APOE, SORL1, BDNF, TOMM40, KIBRA, and COMT. They completed two MTL-dependent tasks, the virtual Morris Water Task (vMWT) and transverse patterning discriminations task (TPDT), and the PFC-dependent reversal learning task. Although age was associated with poorer performance on the vMWT and TPDT within this middle-aged sample, there were no genotype-associated differences in cognitive performance. Although the vMWT and TPDT may be sensitive to age-related changes in cognition, carriers of APOE, SORL1, BDNF, TOMM40, KIBRA, and COMT risk alleles do not exhibit alteration in MTL- and PFC-dependent functioning in middle age compared to non-carriers.

The human hippocampal formation mediates short-term memory of colour-location associations.

PubMed

Finke, Carsten; Braun, Mischa; Ostendorf, Florian; Lehmann, Thomas-Nicolas; Hoffmann, Karl-Titus; Kopp, Ute; Ploner, Christoph J

2008-01-31

The medial temporal lobe (MTL) has long been considered essential for declarative long-term memory, whereas the fronto-parietal cortex is generally seen as the anatomical substrate of short-term memory. This traditional dichotomy is questioned by recent studies suggesting a possible role of the MTL for short-term memory. In addition, there is no consensus on a possible specialization of MTL sub-regions for memory of associative information. Here, we investigated short-term memory for single features and feature associations in three humans with post-surgical lesions affecting the right hippocampal formation and in 10 healthy controls. We used three delayed-match-to-sample tasks with two delays (900/5000 ms) and three set sizes (2/4/6 items). Subjects were instructed to remember either colours, locations or colour-location associations. In colour-only and location-only conditions, performance of patients did not differ from controls. By contrast, a significant group difference was found in the association condition at 5000 ms delay. This difference was largely independent of set size, thus suggesting that it cannot be explained by the increased complexity of the association condition. These findings show that the hippocampal formation plays a significant role for short-term memory of simple visuo-spatial associations, and suggest a specialization of MTL sub-regions for associative memory.

Overexpression of Bacterial mtlD Gene in Peanut Improves Drought Tolerance through Accumulation of Mannitol

PubMed Central

Bhauso, Tengale Dipak; Radhakrishnan, Thankappan; Kumar, Abhay; Mishra, Gyan Prakash; Dobaria, Jentilal Ramjibhai; Patel, Kirankumar; Rajam, Manchikatla Venkat

2014-01-01

In the changing global environmental scenarios, water scarcity and recurrent drought impose huge reductions to the peanut (Arachis hypogaea L.) crop yield. In plants, osmotic adjustments associated with efficient free radical scavenging ability during abiotic stress are important components of stress tolerance mechanisms. Mannitol, a compatible solute, is known to scavenge hydroxyl radicals generated during various abiotic stresses, thereby conferring tolerance to water-deficit stress in many plant species. However, peanut plant is not known to synthesize mannitol. Therefore, bacterial mtlD gene coding for mannitol 1-phosphate dehydrogenase under the control of constitutive promoter CaMV35S was introduced and overexpressed in the peanut cv. GG 20 using Agrobacterium tumefaciens-mediated transformation. A total of eight independent transgenic events were confirmed at molecular level by PCR, Southern blotting, and RT-PCR. Transgenic lines had increased amount of mannitol and exhibited enhanced tolerance in response to water-deficit stress. Improved performance of the mtlD transgenics was indicated by excised-leaf water loss assay and relative water content under water-deficit stress. Better performance of transgenics was due to the ability of the plants to synthesize mannitol. However, regulation of mtlD gene expression in transgenic plants remains to be elucidated. PMID:25436223

Multi-Task Convolutional Neural Network for Pose-Invariant Face Recognition

NASA Astrophysics Data System (ADS)

Yin, Xi; Liu, Xiaoming

2018-02-01

This paper explores multi-task learning (MTL) for face recognition. We answer the questions of how and why MTL can improve the face recognition performance. First, we propose a multi-task Convolutional Neural Network (CNN) for face recognition where identity classification is the main task and pose, illumination, and expression estimations are the side tasks. Second, we develop a dynamic-weighting scheme to automatically assign the loss weight to each side task, which is a crucial problem in MTL. Third, we propose a pose-directed multi-task CNN by grouping different poses to learn pose-specific identity features, simultaneously across all poses. Last but not least, we propose an energy-based weight analysis method to explore how CNN-based MTL works. We observe that the side tasks serve as regularizations to disentangle the variations from the learnt identity features. Extensive experiments on the entire Multi-PIE dataset demonstrate the effectiveness of the proposed approach. To the best of our knowledge, this is the first work using all data in Multi-PIE for face recognition. Our approach is also applicable to in-the-wild datasets for pose-invariant face recognition and achieves comparable or better performance than state of the art on LFW, CFP, and IJB-A datasets.

Allometric relationships among body mass, MUZZLE-tail length, and tibia length during the growth of Wistar rats.

PubMed

Santiago, Hildemberg Agostinho Rocha de; De Pierro, Lucas Rodolfo; Reis, Rafael Menezes; Caluz, Antônio Gabriel Ricardo Engracia; Ribeiro, Victor Barbosa; Volpon, José Batista

2015-11-01

To investigate allometric relationships among body mass (BM), muzzle-tail length (MTL), and tibia length (TL) in Wistar rats and establish their growth rate change parameters. Eighteen male and 18 female Wistar rats were studied from the 3rd to the 21st week of age. BM, MTL, and TL were measured daily, and relative growth was compared using allometry. A positive correlation between BM and MTL (p<0.05) and BM and TL (p<0.05) was observed. Males and females showed comparable curves; however, females had turning points at a younger age. The allometric relationship between BM and MTL presented a regular increase until reaching a mass of 351 g (males) and 405 g (females). BM and TL showed an initial increase until 185 g (males) and 182 g (females), and then reached a plateau that finished at 412 g (males) and 334 g (females), to display another increase. The allometric relationship of body mass with animal length and tibia length was comparable for male and female rats, with female rats maturing earlier. Animal longitudinal growth occurred in a single stage. In contrast, tibia length depicted two stages of accelerated growth with an intermediate period of deceleration.

The Necessity of the Medial Temporal Lobe for Statistical Learning

PubMed Central

Schapiro, Anna C.; Gregory, Emma; Landau, Barbara; McCloskey, Michael; Turk-Browne, Nicholas B.

2014-01-01

The sensory input that we experience is highly patterned, and we are experts at detecting these regularities. Although the extraction of such regularities, or statistical learning (SL), is typically viewed as a cortical process, recent studies have implicated the medial temporal lobe (MTL), including the hippocampus. These studies have employed fMRI, leaving open the possibility that the MTL is involved but not necessary for SL. Here, we examined this issue in a case study of LSJ, a patient with complete bilateral hippocampal loss and broader MTL damage. In Experiments 1 and 2, LSJ and matched control participants were passively exposed to a continuous sequence of shapes, syllables, scenes, or tones containing temporal regularities in the co-occurrence of items. In a subsequent test phase, the control groups exhibited reliable SL in all conditions, successfully discriminating regularities from recombinations of the same items into novel foil sequences. LSJ, however, exhibited no SL, failing to discriminate regularities from foils. Experiment 3 ruled out more general explanations for this failure, such as inattention during exposure or difficulty following test instructions, by showing that LSJ could discriminate which individual items had been exposed. These findings provide converging support for the importance of the MTL in extracting temporal regularities. PMID:24456393

The effect of growth factors on both collagen synthesis and tensile strength of engineered human ligaments.

PubMed

Hagerty, Paul; Lee, Ann; Calve, Sarah; Lee, Cassandra A; Vidal, Martin; Baar, Keith

2012-09-01

Growth factors play a central role in the development and remodelling of musculoskeletal tissues. To determine which growth factors optimized in vitro ligament formation and mechanics, a Box-Behnken designed array of varying concentrations of growth factors and ascorbic acid were applied to engineered ligaments and the collagen content and mechanics of the grafts were determined. Increasing the amount of transforming growth factor (TGF) β1 and insulin-like growth factor (IGF)-1 led to an additive effect on ligament collagen and maximal tensile load (MTL). In contrast, epidermal growth factor (EGF) had a negative effect on both collagen content and MTL. The predicted optimal growth media (50 μg/ml TGFβ, IGF-1, and GDF-7 and 200 μM ascorbic acid) was then validated in two separate trials: showing a 5.7-fold greater MTL and 5.2-fold more collagen than a minimal media. Notably, the effect of the maximized growth media was scalable such that larger constructs developed the same material properties, but larger MTL. These results show that optimizing the interactions between growth factors and engineered ligament volume results in an engineered ligament of clinically relevant function. Copyright © 2012 Elsevier Ltd. All rights reserved.

Intact implicit verbal relational memory in medial temporal lobe amnesia

PubMed Central

Verfaelllie, Mieke; LaRocque, Karen F.; Keane, Margaret M.

2012-01-01

To elucidate the role of the hippocampus in unaware relational memory, the present study examined the performance of amnesic patients with medial temporal lobe (MTL) lesions on a cued category-exemplar generation task. In contrast to a prior study in which amnesic patients showed impaired performance (Verfaellie et al., Cognitive, Affective, and Behavioral Neuroscience, 2006, 6, 91–101), the current study employed a task that required active processing of the context word at test. In this version of the task, amnesic patients, like control participants, showed enhanced category exemplar priming when the context word associated with the target at study was reinstated at test. The finding of intact implicit memory for novel associations following hippocampal lesions in a task that requires flexible use of retrieval cues is inconsistent with a relational memory view that suggests that the hippocampus is critical for all forms of relational memory, regardless of awareness. Instead, it suggests that unaware memory for within-domain associations does not require MTL mediation. PMID:22609574

Dissecting out conscious and unconscious memory (sub)processes within the human medial temporal lobe.

PubMed

Grunwald, T; Pezer, N; Münte, T F; Kurthen, M; Lehnertz, K; Van Roost, D; Fernández, G; Kutas, M; Elger, C E

2003-11-01

The human medial temporal lobe (MTL) system mediates memories that can be consciously recollected. However, the specific natures of the individual contributions of its various subregions to conscious memory processes remain equivocal. Here we show a functional dissociation between the hippocampus proper and the parahippocampal region in conscious and unconscious memory as revealed by invasive recordings of limbic event-related brain potentials recorded during explicit and implicit word recognition: Only hippocampal and not parahippocampal neural activity exhibits a sensitivity to the implicit versus explicit nature of the recognition memory task. Moreover, only within the hippocampus proper do the neural responses to repeated words differ not only from those to new words but also from each other as a function of recognition success. By contrast parahippocampal (rhinal) responses are sensitive to repetition independent of conscious recognition. These findings thus demonstrate that it is the hippocampus proper among the MTL structures that is specifically engaged during conscious memory processes.

The Disconnection Hypothesis in Alzheimer's Disease Studied Through Multimodal Magnetic Resonance Imaging: Structural, Perfusion, and Diffusion Tensor Imaging.

PubMed

Lacalle-Aurioles, María; Navas-Sánchez, Francisco Javier; Alemán-Gómez, Yasser; Olazarán, Javier; Guzmán-De-Villoria, Juan Adán; Cruz-Orduña, Isabel; Mateos-Pérez, José María; Desco, Manuel

2016-01-01

According to the so-called disconnection hypothesis, the loss of synaptic inputs from the medial temporal lobes (MTL) in Alzheimer's disease (AD) may lead to reduced activity of target neurons in cortical areas and, consequently, to decreased cerebral blood flow (CBF) in those areas. The aim of this study was to assess whether hypoperfusion in parietotemporal and frontal cortices of patients with mild cognitive impairment who converted to AD (MCI-c) and patients with mild AD is associated with atrophy in the MTL and/or microstructural changes in the white matter (WM) tracts connecting these areas. We assessed these relationships by investigating correlations between CBF in hypoperfused areas, mean cortical thickness in atrophied regions of the MTL, and fractional anisotropy (FA) in WM tracts. In the MCI-c group, a strong correlation was observed between CBF of the superior parietal gyri and FA in the parahippocampal tracts (left: r = 0.90, p <  0.0001; right: r = 0.597, p = 0.024), and between FA in the right parahippocampal tract and the right precuneus (r = 0.551, p = 0.041). No significant correlations between CBF in hypoperfused regions and FA in the WM tract were observed in the AD group. These results suggest an association between perfusion deficits and altered WM tracts in prodromal AD, while microvasculature impairments may have a greater influence in more advanced stages. We did not find correlations between cortical thinning in the medial temporal lobes and decreased FA in the WM tracts of the limbic system in either group.

Neural mechanism of gastric motility regulation by electroacupuncture at RN12 and BL21: A paraventricular hypothalamic nucleus-dorsal vagal complex-vagus nerve-gastric channel pathway

PubMed Central

Wang, Hao; Liu, Wen-Jian; Shen, Guo-Ming; Zhang, Meng-Ting; Huang, Shun; He, Ying

2015-01-01

AIM: To study the neural mechanism by which electroacupuncture (EA) at RN12 (Zhongwan) and BL21 (Weishu) regulates gastric motility. METHODS: One hundred and forty-four adult Sprague Dawley rats were studied in four separate experiments. Intragastric pressure was measured using custom-made rubber balloons, and extracellular neuron firing activity, which is sensitive to gastric distention in the dorsal vagal complex (DVC), was recorded by an electrophysiological technique. The expression levels of c-fos, motilin (MTL) and gastrin (GAS) in the paraventricular hypothalamic nucleus (PVN) were assayed by immunohistochemistry, and the expression levels of motilin receptor (MTL-R) and gastrin receptor (GAS-R) in both the PVN and the gastric antrum were assayed by western blotting. RESULTS: EA at RN12 + BL21 (gastric Shu and Mu points), BL21 (gastric Back-Shu point), RN12 (gastric Front-Mu point), resulted in increased neuron-activating frequency in the DVC (2.08 ± 0.050, 1.17 ± 0.023, 1.55 ± 0.079 vs 0.75 ± 0.046, P < 0.001) compared with a model group. The expression of c-fos (36.24 ± 1.67, 29.41 ± 2.55, 31.79 ± 3.00 vs 5.73 ± 2.18, P < 0.001), MTL (22.48 ± 2.66, 20.76 ± 2.41, 19.17 ± 1.71 vs 11.68 ± 2.52, P < 0.001), GAS (24.99 ± 2.95, 21.69 ± 3.24, 23.03 ± 3.09 vs 12.53 ± 2.15, P < 0.001), MTL-R (1.39 ± 0.05, 1.22 ± 0.05, 1.17 ± 0.12 vs 0.84 ± 0.06, P < 0.001), and GAS-R (1.07 ± 0.07, 0.91 ± 0.06, 0.78 ± 0.05 vs 0.45 ± 0.04, P < 0.001) increased in the PVN after EA compared with the model group. The expression of MTL-R (1.46 ± 0.14, 1.26 ± 0.11, 0.99 ± 0.07 vs 0.65 ± 0.03, P < 0.001), and GAS-R (1.63 ± 0.11, 1.26 ± 0.16, 1.13 ± 0.02 vs 0.80 ± 0.11, P < 0.001) increased in the gastric antrum after EA compared with the model group. Damaging the PVN resulted in reduced intragastric pressure (13.67 ± 3.72 vs 4.27 ± 1.48, P < 0.001). These data demonstrate that the signals induced by EA stimulation of acupoints RN12 and BL21 are detectable in the DVC and the PVN, and increase the levels of gastrointestinal hormones and their receptors in the PVN and gastric antrum to regulate gastric motility. CONCLUSION: EA at RN12 and BL21 regulates gastric motility, which may be achieved through the PVN-DVC-vagus-gastric neural pathway. PMID:26730159

Flammability Characteristics of Fiber Reinforced Composite Materials

DTIC Science & Technology

1990-08-01

Thick Vertical Sheet of Kevlar/Phenolio-PVB ( Owens - Corning $pall Liner), MTL A4) 3 12 Chemical Heat Release Rate During Fire Propagation for a 40 0.61 m...Long, 0.10 m Wide and 3 mm Thick Vertical Sheet of S-2/Phenolic ( Owens - Corning ), MTL #5) 13 Chemical Heac Release Rate During Fire Propagation for 41...Materials T eohnology Laboratory (AKTL) by Owens - Corning Corporation; 3. NTL #3: S-2 fiberglabs/polyestel’, flame retardant, prepreg, formulated for

Thalamo-Cortical Disruption Contributes to Short-Term Memory Deficits in Patients with Medial Temporal Lobe Damage.

PubMed

Voets, Natalie L; Menke, Ricarda A L; Jbabdi, Saad; Husain, Masud; Stacey, Richard; Carpenter, Katherine; Adcock, Jane E

2015-11-01

Short-term (STM) and long-term memory (LTM) have largely been considered as separate brain systems reflecting fronto-parietal and medial temporal lobe (MTL) functions, respectively. This functional dichotomy has been called into question by evidence of deficits on aspects of working memory in patients with MTL damage, suggesting a potentially direct hippocampal contribution to STM. As the hippocampus has direct anatomical connections with the thalamus, we tested the hypothesis that damage to thalamic nuclei regulating cortico-cortical interactions may contribute to STM deficits in patients with hippocampal dysfunction. We used diffusion-weighted magnetic resonance imaging-based tractography to identify anatomical subdivisions in patients with MTL epilepsy. From these, we measured resting-state functional connectivity with detailed cortical divisions of the frontal, temporal, and parietal lobes. Whereas thalamo-temporal functional connectivity reflected LTM performance, thalamo-prefrontal functional connectivity specifically predicted STM performance. Notably, patients with hippocampal volume loss showed thalamic volume loss, most prominent in the pulvinar region, not detected in patients with normal hippocampal volumes. Aberrant thalamo-cortical connectivity in the epileptic hemisphere was mirrored in a loss of behavioral association with STM performance specifically in patients with hippocampal atrophy. These findings identify thalamo-cortical disruption as a potential mechanism contributing to STM deficits in the context of MTL damage. © The Author 2015. Published by Oxford University Press.

Visual working memory capacity and the medial temporal lobe.

PubMed

Jeneson, Annette; Wixted, John T; Hopkins, Ramona O; Squire, Larry R

2012-03-07

Patients with medial temporal lobe (MTL) damage are sometimes impaired at remembering visual information across delays as short as a few seconds. Such impairments could reflect either impaired visual working memory capacity or impaired long-term memory (because attention has been diverted or because working memory capacity has been exceeded). Using a standard change-detection task, we asked whether visual working memory capacity is intact or impaired after MTL damage. Five patients with hippocampal lesions and one patient with large MTL lesions saw an array of 1, 2, 3, 4, or 6 colored squares, followed after 3, 4, or 8 s by a second array where one of the colored squares was cued. The task was to decide whether the cued square had the same color as the corresponding square in the first array or a different color. At the 1 s delay typically used to assess working memory capacity, patients performed as well as controls at all array sizes. At the longer delays, patients performed as well as controls at small array sizes, thought to be within the capacity limit, and worse than controls at large array sizes, thought to exceed the capacity limit. The findings suggest that visual working memory capacity in humans is intact after damage to the MTL structures and that damage to these structures impairs performance only when visual working memory is insufficient to support performance.

A High-Resolution Study of Hippocampal and Medial Temporal Lobe Correlates of Spatial Context and Prospective Overlapping Route Memory

PubMed Central

Brown, Thackery I.; Hasselmo, Michael E.; Stern, Chantal E.

2015-01-01

When navigating our world we often first plan or retrieve an ideal route to our goal, avoiding alternative paths that lead to other destinations. The medial temporal lobe (MTL) has been implicated in processing contextual information, sequence memory, and uniquely retrieving routes that overlap or “cross paths.” However, the identity of subregions of the hippocampus and neighboring cortex that support these functions in humans remains unclear. The present study used high-resolution functional magnetic resonance imaging (hr-fMRI) in humans to test whether the CA3/DG hippocampal subfield and para-hippocampal cortex are important for processing spatial context and route retrieval, and whether the CA1 subfield facilitates prospective planning of mazes that must be distinguished from alternative overlapping routes. During hr-fMRI scanning, participants navigated virtual mazes that were well-learned from prior training while also learning new mazes. Some routes learned during scanning shared hallways with those learned during pre-scan training, requiring participants to select between alternative paths. Critically, each maze began with a distinct spatial contextual Cue period. Our analysis targeted activity from the Cue period, during which participants identified the current navigational episode, facilitating retrieval of upcoming route components and distinguishing mazes that overlap. Results demonstrated that multiple MTL regions were predominantly active for the contextual Cue period of the task, with specific regions of CA3/DG, parahippocampal cortex, and perirhinal cortex being consistently recruited across trials for Cue periods of both novel and familiar mazes. During early trials of the task, both CA3/DG and CA1 were more active for overlapping than non-overlapping Cue periods. Trial-by-trial Cue period responses in CA1 tracked subsequent overlapping maze performance across runs. Together, our findings provide novel insight into the contributions of MTL subfields to processing spatial context and route retrieval, and support a prominent role for CA1 in distinguishing overlapping episodes during navigational “look-ahead” periods. PMID:24659134

Test-Retest Reliability of fMRI Brain Activity during Memory Encoding

PubMed Central

Brandt, David J.; Sommer, Jens; Krach, Sören; Bedenbender, Johannes; Kircher, Tilo; Paulus, Frieder M.; Jansen, Andreas

2013-01-01

The mechanisms underlying hemispheric specialization of memory are not completely understood. Functional magnetic resonance imaging (fMRI) can be used to develop and test models of hemispheric specialization. In particular for memory tasks however, the interpretation of fMRI results is often hampered by the low reliability of the data. In the present study we therefore analyzed the test-retest reliability of fMRI brain activation related to an implicit memory encoding task, with a particular focus on brain activity of the medial temporal lobe (MTL). Fifteen healthy subjects were scanned with fMRI on two sessions (average retest interval 35 days) using a commonly applied novelty encoding paradigm contrasting known and unknown stimuli. To assess brain lateralization, we used three different stimuli classes that differed in their verbalizability (words, scenes, fractals). Test-retest reliability of fMRI brain activation was assessed by an intraclass-correlation coefficient (ICC), describing the stability of inter-individual differences in the brain activation magnitude over time. We found as expected a left-lateralized brain activation network for the words paradigm, a bilateral network for the scenes paradigm, and predominantly right-hemispheric brain activation for the fractals paradigm. Although these networks were consistently activated in both sessions on the group level, across-subject reliabilities were only poor to fair (ICCs ≤ 0.45). Overall, the highest ICC values were obtained for the scenes paradigm, but only in strongly activated brain regions. In particular the reliability of brain activity of the MTL was poor for all paradigms. In conclusion, for novelty encoding paradigms the interpretation of fMRI results on a single subject level is hampered by its low reliability. More studies are needed to optimize the retest reliability of fMRI activation for memory tasks. PMID:24367338

Dollar Summary of Federal Supply Classification and Service Category by Company, FY84, Part 1 (1005-2610).

DTIC Science & Technology

1984-01-01

350 STATE TOTAL 377 NEBRASKA ARMY TRACTORS WHEELED 111 CONTRACTOR TOTAL 488 PINE BUSH EQUIPMENT CO INC NEW YORK ARMY TRACTORS WHEELED 49 PSI MOBILE...ARMY VEHICULAR FURNITURE AND ACCESSORIES 48- AURORA CORD a CABLE CO INC ILLINOIS ARMY VEHICULAR FURNITURE AND ACCESSORIES 211 BARREN RV MTL HTH/MTL...MICHIGAN ARMY VEHICULAR BRAKE STEERING AXLE WHEEL COMP 702 PENN ARMY VEHICULAR BRAKE STEERING AXLE WHEEL COMP 32 CONTRACTOR TOTAL 734 RYAN CHRYSLER PLYMOUTH

Adaptive Sensing and Fusion of Multi-Sensor Data and Historical Information

DTIC Science & Technology

2009-11-06

integrate MTL and semi-supervised learning into a single framework , thereby exploiting two forms of contextual information. A key new objective of the...this report we integrate MTL and semi-supervised learning into a single framework , thereby exploiting two forms of contextual information. A key new...process [8], denoted as X ∼ BeP (B), where B is a measure on Ω. If B is continuous, X is a Poisson process with intensity B and can be constructed as X = N

Economic growth and marine biodiversity: influence of human social structure on decline of marine trophic levels.

PubMed

Clausen, Rebecca; York, Richard

2008-04-01

We assessed the effects of economic growth, urbanization, and human population size on marine biodiversity. We used the mean trophic level (MTL) of marine catch as an indicator of marine biodiversity and conducted cross-national time-series analyses (1960-2003) of 102 nations to investigate human social influences on fish catch and trends in MTL. We constructed path models to examine direct and indirect effects relating to marine catch and MTL. Nations' MTLs declined with increased economic growth, increased urbanization, and increased population size, in part because of associated increased catch. These findings contradict the environmental Kuznets curve hypothesis, which claims that economic modernization will reduce human impact on the environment. To make informed decisions on issues of marine resource management, policy makers, nonprofit entities, and professional societies must recognize the need to include social analyses in overall conservation-research strategies. The challenge is to utilize the socioeconomic and ecological research in the service of a comprehensive marine-conservation movement.

Multi-Task Learning with Low Rank Attribute Embedding for Multi-Camera Person Re-Identification.

PubMed

Su, Chi; Yang, Fan; Zhang, Shiliang; Tian, Qi; Davis, Larry Steven; Gao, Wen

2018-05-01

We propose Multi-Task Learning with Low Rank Attribute Embedding (MTL-LORAE) to address the problem of person re-identification on multi-cameras. Re-identifications on different cameras are considered as related tasks, which allows the shared information among different tasks to be explored to improve the re-identification accuracy. The MTL-LORAE framework integrates low-level features with mid-level attributes as the descriptions for persons. To improve the accuracy of such description, we introduce the low-rank attribute embedding, which maps original binary attributes into a continuous space utilizing the correlative relationship between each pair of attributes. In this way, inaccurate attributes are rectified and missing attributes are recovered. The resulting objective function is constructed with an attribute embedding error and a quadratic loss concerning class labels. It is solved by an alternating optimization strategy. The proposed MTL-LORAE is tested on four datasets and is validated to outperform the existing methods with significant margins.

[Magnetotherapy of initial manifestations of cerebrovascular disorders in hypertension].

PubMed

Miasnikov, I G

1992-01-01

The paper is concerned with the data on 147 subjects who underwent magnetotherapy with the unit "Magniter-AMT-01" applied to the cervical area. The main group included 102 subjects, 45 person served as control. The purpose of the work was to base the application of MT under inpatient and home conditions with the use of the above-indicated unit. In view of this fact, a study was made of cerebral hemo- and thermodynamics with the aid of rheoencephalography and encephaloradiothermography under the action of different modes of the functioning of the unit "Magniter-AMT-01" (pulse and variable magnet induction fields 12-15 mTl and 30-35 mTl). A method of measuring magnetosensitivity of patients depending on the temperature reaction of the brain to a single MT session was elaborated. The greatest clinical effect was attained with the use of pulse magnetic field 15 mTl. Magnetotherapy with the use of the unit "Magniter-AMT-01" provided good results under inpatient and home conditions. The magnetosensitive patients demonstrated the highest effect.

Selective neuronal lapses precede human cognitive lapses following sleep deprivation.

PubMed

Nir, Yuval; Andrillon, Thomas; Marmelshtein, Amit; Suthana, Nanthia; Cirelli, Chiara; Tononi, Giulio; Fried, Itzhak

2017-12-01

Sleep deprivation is a major source of morbidity with widespread health effects, including increased risk of hypertension, diabetes, obesity, heart attack, and stroke. Moreover, sleep deprivation brings about vehicle accidents and medical errors and is therefore an urgent topic of investigation. During sleep deprivation, homeostatic and circadian processes interact to build up sleep pressure, which results in slow behavioral performance (cognitive lapses) typically attributed to attentional thalamic and frontoparietal circuits, but the underlying mechanisms remain unclear. Recently, through study of electroencephalograms (EEGs) in humans and local field potentials (LFPs) in nonhuman primates and rodents it was found that, during sleep deprivation, regional 'sleep-like' slow and theta (slow/theta) waves co-occur with impaired behavioral performance during wakefulness. Here we used intracranial electrodes to record single-neuron activities and LFPs in human neurosurgical patients performing a face/nonface categorization psychomotor vigilance task (PVT) over multiple experimental sessions, including a session after full-night sleep deprivation. We find that, just before cognitive lapses, the selective spiking responses of individual neurons in the medial temporal lobe (MTL) are attenuated, delayed, and lengthened. These 'neuronal lapses' are evident on a trial-by-trial basis when comparing the slowest behavioral PVT reaction times to the fastest. Furthermore, during cognitive lapses, LFPs exhibit a relative local increase in slow/theta activity that is correlated with degraded single-neuron responses and with baseline theta activity. Our results show that cognitive lapses involve local state-dependent changes in neuronal activity already present in the MTL.

Algorithm-Dependent Generalization Bounds for Multi-Task Learning.

PubMed

Liu, Tongliang; Tao, Dacheng; Song, Mingli; Maybank, Stephen J

2017-02-01

Often, tasks are collected for multi-task learning (MTL) because they share similar feature structures. Based on this observation, in this paper, we present novel algorithm-dependent generalization bounds for MTL by exploiting the notion of algorithmic stability. We focus on the performance of one particular task and the average performance over multiple tasks by analyzing the generalization ability of a common parameter that is shared in MTL. When focusing on one particular task, with the help of a mild assumption on the feature structures, we interpret the function of the other tasks as a regularizer that produces a specific inductive bias. The algorithm for learning the common parameter, as well as the predictor, is thereby uniformly stable with respect to the domain of the particular task and has a generalization bound with a fast convergence rate of order O(1/n), where n is the sample size of the particular task. When focusing on the average performance over multiple tasks, we prove that a similar inductive bias exists under certain conditions on the feature structures. Thus, the corresponding algorithm for learning the common parameter is also uniformly stable with respect to the domains of the multiple tasks, and its generalization bound is of the order O(1/T), where T is the number of tasks. These theoretical analyses naturally show that the similarity of feature structures in MTL will lead to specific regularizations for predicting, which enables the learning algorithms to generalize fast and correctly from a few examples.

Impaired familiarity with preserved recollection after anterior temporal-lobe resection that spares the hippocampus.

PubMed

Bowles, Ben; Crupi, Carina; Mirsattari, Seyed M; Pigott, Susan E; Parrent, Andrew G; Pruessner, Jens C; Yonelinas, Andrew P; Köhler, Stefan

2007-10-09

It is well established that the medial-temporal lobe (MTL) is critical for recognition memory. The MTL is known to be composed of distinct structures that are organized in a hierarchical manner. At present, it remains controversial whether lower structures in this hierarchy, such as perirhinal cortex, support memory functions that are distinct from those of higher structures, in particular the hippocampus. Perirhinal cortex has been proposed to play a specific role in the assessment of familiarity during recognition, which can be distinguished from the selective contributions of the hippocampus to the recollection of episodic detail. Some researchers have argued, however, that the distinction between familiarity and recollection cannot capture functional specialization within the MTL and have proposed single-process accounts. Evidence supporting the dual-process view comes from demonstrations that selective hippocampal damage can produce isolated recollection impairments. It is unclear, however, whether temporal-lobe lesions that spare the hippocampus can produce selective familiarity impairments. Without this demonstration, single-process accounts cannot be ruled out. We examined recognition memory in NB, an individual who underwent surgical resection of left anterior temporal-lobe structures for treatment of intractable epilepsy. Her resection included a large portion of perirhinal cortex but spared the hippocampus. The results of four experiments based on three different experimental procedures (remember-know paradigm, receiver operating characteristics, and response-deadline procedure) indicate that NB exhibits impaired familiarity with preserved recollection. The present findings thus provide a crucial missing piece of support for functional specialization in the MTL.

Rhinal-hippocampal interactions during déjà vu.

PubMed

Bartolomei, Fabrice; Barbeau, Emmanuel J; Nguyen, Trung; McGonigal, Aileen; Régis, Jean; Chauvel, Patrick; Wendling, Fabrice

2012-03-01

The phenomenon of 'déjà vu' is caused by acute disturbance of mnemonic systems of the medial temporal lobe (MTL). In epileptic patients investigated with intracerebral electrodes, déjà vu can be more readily induced by stimulation of the rhinal cortices (RCs) than the hippocampus (H). Whether déjà vu results from acute dysfunction of the familiarity system alone (sustained by RC) or from more extensive involvement of the MTL region (including H) is debatable. We analysed the synchronisation of intracerebral electroencephalography (EEG) signals recorded from RC, H and amygdala (A) in epileptic patients in whom déjà vu was induced by electrical stimulation. EEG signal correlations (between signals from RC, A and H) were evaluated using a nonlinear regression. In comparison with RC stimulations that did not lead to déjà vu (DV-), stimulations triggering déjà vu (DV+) were associated with increased broadband EEG correlation (p=0.01). Changes in correlations were significantly different in the theta band for RC-A (p=0.007) and RC-H (p=0.01) and in the beta band for RC-H (p=0.001) interactions. Déjà vu is associated with increased EEG signal correlation between MTL structures. Results are in favour of a mechanism involving transient co-operation between various MTL structures, not limited to RC alone. Copyright © 2011 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.

Nutrition labels: a survey of use, understanding and preferences among ethnically diverse shoppers in New Zealand.

PubMed

Gorton, Delvina; Ni Mhurchu, Cliona; Chen, Mei-Hua; Dixon, Robyn

2009-09-01

Effective nutrition labels are part of a supportive environment that encourages healthier food choices. The present study examined the use, understanding and preferences regarding nutrition labels among ethnically diverse shoppers in New Zealand. A survey was carried out at twenty-five supermarkets in Auckland, New Zealand, between February and April 2007. Recruitment was stratified by ethnicity. Questions assessed nutrition label use, understanding of the mandatory Nutrition Information Panel (NIP), and preference for and understanding of four nutrition label formats: multiple traffic light (MTL), simple traffic light (STL), NIP and percentage of daily intake (%DI). In total 1525 shoppers completed the survey: 401 Maori, 347 Pacific, 372 Asian and 395 New Zealand European and Other ethnicities (ten did not state ethnicity). Reported use of nutrition labels (always, regularly, sometimes) ranged from 66% to 87% by ethnicity. There was little difference in ability to obtain information from the NIP according to ethnicity or income. However, there were marked ethnic differences in ability to use the NIP to determine if a food was healthy, with lesser differences by income. Of the four label formats tested, STL and MTL labels were best understood across all ethnic and income groups, and MTL labels were most frequently preferred. There are clear ethnic and income disparities in ability to use the current mandatory food labels in New Zealand (NIP) to determine if foods are healthy. Conversely, MTL and STL label formats demonstrated high levels of understanding and acceptance across ethnic and income groups.

Probabilistic Classification Learning with Corrective Feedback Is Selectively Impaired in Early Huntington's Disease--Evidence for the Role of the Striatum in Learning with Feedback

ERIC Educational Resources Information Center

Holl, Anna K.; Wilkinson, Leonora; Tabrizi, Sarah J.; Painold, Annamaria; Jahanshahi, Marjan

2012-01-01

In general, declarative learning is associated with the activation of the medial temporal lobes (MTL), while the basal ganglia (BG) are considered the substrate for procedural learning. More recently it has been demonstrated the distinction of these systems may not be as absolute as previously thought and that not only the explicit or implicit…

High yield cell-free production of integral membrane proteins without refolding or detergents.

PubMed

Wuu, Jessica J; Swartz, James R

2008-05-01

Integral membrane proteins act as critical cellular components and are important drug targets. However, difficulties in producing membrane proteins have hampered investigations of structure and function. In vivo production systems are often limited by cell toxicity, and previous in vitro approaches have required unnatural folding pathways using detergents or lipid solutions. To overcome these limitations, we present an improved cell-free expression system which produces high yields of integral membrane proteins without the use of detergents or refolding steps. Our cell-free reaction activates an Escherichia coli-derived cell extract for transcription and translation. Purified E. coli inner membrane vesicles supply membrane-bound components and the lipid environment required for insertion and folding. Using this system, we demonstrated successful synthesis of two complex integral membrane transporters, the tetracycline pump (TetA) and mannitol permease (MtlA), in yields of 570+/-50 microg/mL and 130+/-30 microg/mL of vesicle-associated protein, respectively. These yields are up to 400 times typical in vivo concentrations. Insertion and folding of these proteins are verified by sucrose flotation, protease digestion, and activity assays. Whereas TetA incorporates efficiently into vesicle membranes with over two-thirds of the synthesized protein being inserted, MtlA yields appear to be limited by insufficient concentrations of a membrane-associated chaperone.

COMT val108/158 met genotype affects neural but not cognitive processing in healthy individuals.

PubMed

Dennis, Nancy A; Need, Anna C; LaBar, Kevin S; Waters-Metenier, Sheena; Cirulli, Elizabeth T; Kragel, James; Goldstein, David B; Cabeza, Roberto

2010-03-01

The relationship between cognition and a functional polymorphism in the catechol-O-methlytransferase (COMT) gene, val108/158met, is one of debate in the literature. Furthermore, based on the dopaminergic differences associated with the COMT val108/158met genotype, neural differences during cognition may be present, regardless of genotypic differences in cognitive performance. To investigate these issues the current study aimed to 1) examine the effects of COMT genotype using a large sample of healthy individuals (n = 496-1218) and multiple cognitive measures, and using a subset of the sample (n = 22), 2) examine whether COMT genotype effects medial temporal lobe (MTL) and frontal activity during successful relational memory processing, and 3) investigate group differences in functional connectivity associated with successful relational memory processing. Results revealed no significant group difference in cognitive performance between COMT genotypes in any of the 19 cognitive measures. However, in the subset sample, COMT val homozygotes exhibited significantly decreased MTL and increased prefrontal activity during both successful relational encoding and retrieval, and reduced connectivity between these regions compared with met homozygotes. Taken together, the results suggest that although the COMT val108/158met genotype has no effect on cognitive behavioral measures in healthy individuals, it is associated with differences in neural process underlying cognitive output.

Neural correlates of remembering/knowing famous people: an event-related fMRI study.

PubMed

Denkova, Ekaterina; Botzung, Anne; Manning, Lilianne

2006-01-01

It has been suggested that knowledge about some famous people depends on both a generic semantic component and an autobiographical component [Westmacott, R., & Moscovitch, M. (2003). The contribution of autobiographical significance to semantic memory. Memory and Cognition, 31, 761-774]. The neuropsychological studies of semantic dementia (SD) and Alzheimer disease (AD) demonstrated that the two aspects are very likely to be mediated by different brain structures, with the episodic component being highly dependent upon the integrity of the medial temporal lobe (MTL) [Westmacott, R., Black, S. E., Freedman, M., & Moscovitch, M. (2004). The contribution of autobiographical significance to semantic memory: Evidence from Alzheimer's disease, semantic dementia, and amnesia. Neuropsychologia, 42, 25-48]. Using an fMRI design in healthy participants, we aimed: (i) to investigate the pattern of brain activations sustaining the autobiographical and the semantic aspects of knowledge about famous persons. Moreover, (ii) we examined if the stimulus material (face/name) influences the lateralisation of the cerebral networks. Our findings suggested that different patterns of activation corresponded to the presence or absence of personal significance linked to semantic knowledge; MTL was engaged only in the former case. Although choice of stimulus material did not influence the hemispheric lateralisation in "classical" terms, it did play a role in engaging different cerebral regions.

Human papillomavirus type 56 polymorphism in Canadian women with and without cervical lesions.

PubMed

Rodrigues-Coutlée, Catherine; Archambault, Jacques; Money, Deborah; Ramanakumar, Agnihotram V; Raboud, Janet; Hankins, Catherine; Koushik, Anita; Richardson, Harriet; Brassard, Paul; Franco, Eduardo L; Coutlée, Francois

2013-12-01

The genomic diversity of high-risk human papillomaviruses (HPV) has been associated with viral persistence and HPV-induced lesions. Studies on HPV56 persistence are still pending. To assess the association between HPV56 polymorphism and HPV56 persistence and presence of high-grade cervical intraepithelial neoplasia (CIN2,3) or cancer. HPV56-positive cervical specimens from 204 women selected from a total of 4669 participants recruited in 5 epidemiological studies (parent studies) were further analyzed by PCR-sequencing of the long control region (LCR). Of the 81 women followed prospectively in cohort studies who could be classified, 34 had persistent and 47 had transient HPV56 infections. Variant HPV56-LCR-MTL-21 was detected more frequently in persistent infections (52.9%, 95% CI: 36.7-68.6%) than in transient infections (25.5%, 95% CI: 15.1-39.4). Considering only women recruited in a cohort of women infected or at high risk for HIV infection, infection with variant HPV56-LCR-MTL-21 (OR=4.4, 95% CI: 1.3-14.5) was significantly associated with HPV56 persistence controlling in multivariate analysis for high risk HPV detection and HIV infection. A variation at nucleotide 7800 in HPV56-LCR-MTL-21 resulted in the loss of a binding site for Elf-1 embedded in one of the E2 binding sites, a potential activator or repressor of expression of the HPV genome. HPV56 polymorphism was not associated with CIN2,3 or cancer in women enrolled in cross-sectional and case-control studies. Polymorphism in HPV56 may influence the risk that infections with this type will persist. Copyright © 2013 Elsevier B.V. All rights reserved.

fMRI responses to words repeated in a congruous semantic context are abnormal in mild Alzheimer’s disease

PubMed Central

Olichney, John M.; Taylor, Jason R.; Chan, Shiaohui; Yang, Jin-Chen; Stringfellow, Andrew; Hillert, Dieter G.; Simmons, Amanda L.; Salmon, David P.; Iragui-Madoz, Vicente; Kutas, Marta

2010-01-01

Background We adapted an event-related brain potential word repetition paradigm, sensitive to early Alzheimer’s disease (AD), for functional MRI (fMRI). We hypothesized that AD would be associated with reduced differential response to new/old congruous words. Methods Fifteen mild AD patients (mean age = 72.9) and 15 normal elderly underwent 1.5T fMRI during a semantic category decision task. Results We found robust between-groups differences in BOLD response to congruous words. In controls, the New > Old contrast demonstrated larger responses in much of the left-hemisphere (including putative P600 generators: parahippocampal, cingulate, fusiform, perirhinal, middle temporal (MTG) and inferior frontal gyri (IFG)); the Old > New contrast showed modest activation, mainly in right parietal and prefrontal cortex. By contrast, there were relatively few regions of significant New > Old responses in AD patients, mainly in the right-hemisphere, and their Old > New contrast did not demonstrate a right-hemisphere predominance. Across subjects, the spatial extent of New > Old responses in left medial temporal lobe (MTL) correlated with subsequent recall and recognition (r’s ≥ 0.60). In controls, the magnitude of New - Old response in left MTL, fusiform, IFG, MTG, superior temporal and cingulate gyrus correlated with subsequent cued recall and/or recognition (0.51 ≤ r’s ≤ 0.78). Conclusions A distributed network of mostly left-hemisphere structures, which are putative P600 generators, appears important for successful verbal encoding (with New > Old responses to congruous words in normal elderly). This network appears dysfunctional in mild AD patients, as reflected in decreased word repetition effects particularly in left association cortex, paralimbic and MTL structures. PMID:20433856

Mean Tide Level Data in the PSMSL Mean Sea Level Dataset

NASA Astrophysics Data System (ADS)

Matthews, Andrew; Bradshaw, Elizabeth; Gordon, Kathy; Jevrejeva, Svetlana; Rickards, Lesley; Tamisiea, Mark; Williams, Simon; Woodworth, Philip

2016-04-01

The Permanent Service for Mean Sea Level (PSMSL) is the internationally recognised global sea level data bank for long term sea level change information from tide gauges. Established in 1933, the PSMSL continues to be responsible for the collection, publication, analysis and interpretation of sea level data. The PSMSL operates under the auspices of the International Council for Science (ICSU), is a regular member of the ICSU World Data System and is associated with the International Association for the Physical Sciences of the Oceans (IAPSO) and the International Association of Geodesy (IAG). The PSMSL continues to work closely with other members of the sea level community through the Intergovernmental Oceanographic Commission's Global Sea Level Observing System (GLOSS). Currently, the PSMSL data bank holds over 67,000 station-years of monthly and annual mean sea level data from over 2250 tide gauge stations. Data from each site are quality controlled and, wherever possible, reduced to a common datum, whose stability is monitored through a network of geodetic benchmarks. PSMSL also distributes a data bank of measurements taken from in-situ ocean bottom pressure recorders. Most of the records in the main PSMSL dataset indicate mean sea level (MSL), derived from high-frequency tide gauge data, with sampling typically once per hour or higher. However, some of the older data is based on mean tide level (MTL), which is obtained from measurements taken at high and low tide only. While usually very close, MSL and MTL can occasionally differ by many centimetres, particularly in shallow water locations. As a result, care must be taken when using long sea level records that contain periods of MTL data. Previously, periods during which the values indicated MTL rather than MSL were noted in the documentation, and sometimes suggested corrections were supplied. However, these comments were easy to miss, particularly in large scale studies that used multiple stations from across a wide area. Therefore, the PSMSL have decided to begin applying a correction to all mixed MTL/MSL records in its datum-controlled RLR dataset, where a suitable correction is available. These corrections will be clearly flagged, allowing users of PSMSL data to quickly identify these values and ignore these data, or apply a different correction. Here we describe the corrections applied to the PSMSL dataset, how users can find MTL data and the corrections made, and some caveats and warnings that need to be considered.

The neuroscience of positive memory deficits in depression

PubMed Central

Dillon, Daniel G.

2015-01-01

Adults with unipolar depression typically show poor episodic memory for positive material, but the neuroscientific mechanisms responsible for this deficit have not been characterized. I suggest a simple hypothesis: weak memory for positive material in depression reflects disrupted communication between the mesolimbic dopamine pathway and medial temporal lobe (MTL) memory systems during encoding. This proposal draws on basic research showing that dopamine release in the hippocampus is critical for the transition from early- to late-phase long-term potentiation (LTP) that marks the conversion of labile, short-term memories into stable, long-term memories. Neuroimaging and pharmacological data from healthy humans paint a similar picture: activation of the mesolimbic reward circuit enhances encoding and boosts retention. Unipolar depression is characterized by anhedonia–loss of pleasure–and reward circuit dysfunction, which is believed to reflect negative effects of stress on the mesolimbic dopamine pathway. Thus, I propose that the MTL is deprived of strengthening reward signals in depressed adults and memory for positive events suffers accordingly. Although other mechanisms are important, this hypothesis holds promise as an explanation for positive memory deficits in depression. PMID:26441703

Downstream effects of hippocampal sharp wave ripple oscillations on medial entorhinal cortex layer V neurons in vitro.

PubMed

Roth, Fabian C; Beyer, Katinka M; Both, Martin; Draguhn, Andreas; Egorov, Alexei V

2016-12-01

The entorhinal cortex (EC) is a critical component of the medial temporal lobe (MTL) memory system. Local networks within the MTL express a variety of state-dependent network oscillations that are believed to organize neuronal activity during memory formation. The peculiar pattern of sharp wave-ripple complexes (SPW-R) entrains neurons by a very fast oscillation at ∼200 Hz in the hippocampal areas CA3 and CA1 and then propagates through the "output loop" into the EC. The precise mechanisms of SPW-R propagation and the resulting cellular input patterns in the mEC are, however, largely unknown. We therefore investigated the activity of layer V (LV) principal neurons of the medial EC (mEC) during SPW-R oscillations in horizontal mouse brain slices. Intracellular recordings in the mEC were combined with extracellular monitoring of propagating network activity. SPW-R in CA1 were regularly followed by negative field potential deflections in the mEC. Propagation of SPW-R activity from CA1 to the mEC was mostly monosynaptic and excitatory, such that synaptic input to mEC LV neurons directly reflected unit activity in CA1. Comparison with propagating network activity from CA3 to CA1 revealed a similar role of excitatory long-range connections for both regions. However, SPW-R-induced activity in CA1 involved strong recruitment of rhythmic synaptic inhibition and corresponding fast field oscillations, in contrast to the mEC. These differences between features of propagating SPW-R emphasize the differential processing of network activity by each local network of the hippocampal output loop. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Burbank works on the CIR in the U.S. Laboratory

NASA Image and Video Library

2012-04-10

ISS030-E-234735 (10 April 2012) --- NASA astronaut Dan Burbank, Expedition 30 commander, works on the Combustion Integrated Rack (CIR) in the Destiny laboratory of the International Space Station. Burbank disconnected the Moderate Temperature Loop (MTL), Vacuum Exhaust System (VES) and station nitrogen lines of the Optics Bench, translated and rotated it out of the way and replaced a Fluids and Combustion Facility / Diagnostic Control Module (FCF DCM) on its back. Afterwards, Burbank returned the Optics Bench to its nominal position and reconnected the MTL, VES and station nitrogen lines.

Characterization of the IEC 61000-4-6 Electromagnetic Clamp for Conducted-Immunity Testing

NASA Astrophysics Data System (ADS)

Grassi, F.; Pignari, S. A.; Spadacini, G.; Toscani, N.; Pelissou, P.

2016-05-01

A multiconductor transmission line model (MTL) is used to investigate the operation of the IEC 61000-4-6 electromagnetic (EM) clamp in a conducted-immunity test setup for aerospace applications. Aspects of interest include the performance of such a coupling device at very high frequencies (up to 1 GHz), and for extreme values of the common-mode impedance of equipment (short circuits, open circuits). The MTL model is finally exploited to predict the frequency response of coupling and decoupling factors defined in the IEC 61000-4-6 standard.

HD-MTL: Hierarchical Deep Multi-Task Learning for Large-Scale Visual Recognition.

PubMed

Fan, Jianping; Zhao, Tianyi; Kuang, Zhenzhong; Zheng, Yu; Zhang, Ji; Yu, Jun; Peng, Jinye

2017-02-09

In this paper, a hierarchical deep multi-task learning (HD-MTL) algorithm is developed to support large-scale visual recognition (e.g., recognizing thousands or even tens of thousands of atomic object classes automatically). First, multiple sets of multi-level deep features are extracted from different layers of deep convolutional neural networks (deep CNNs), and they are used to achieve more effective accomplishment of the coarseto- fine tasks for hierarchical visual recognition. A visual tree is then learned by assigning the visually-similar atomic object classes with similar learning complexities into the same group, which can provide a good environment for determining the interrelated learning tasks automatically. By leveraging the inter-task relatedness (inter-class similarities) to learn more discriminative group-specific deep representations, our deep multi-task learning algorithm can train more discriminative node classifiers for distinguishing the visually-similar atomic object classes effectively. Our hierarchical deep multi-task learning (HD-MTL) algorithm can integrate two discriminative regularization terms to control the inter-level error propagation effectively, and it can provide an end-to-end approach for jointly learning more representative deep CNNs (for image representation) and more discriminative tree classifier (for large-scale visual recognition) and updating them simultaneously. Our incremental deep learning algorithms can effectively adapt both the deep CNNs and the tree classifier to the new training images and the new object classes. Our experimental results have demonstrated that our HD-MTL algorithm can achieve very competitive results on improving the accuracy rates for large-scale visual recognition.

Memory for Items and Relationships among Items Embedded in Realistic Scenes: Disproportionate Relational Memory Impairments in Amnesia

PubMed Central

Hannula, Deborah E.; Tranel, Daniel; Allen, John S.; Kirchhoff, Brenda A.; Nickel, Allison E.; Cohen, Neal J.

2014-01-01

Objective The objective of this study was to examine the dependence of item memory and relational memory on medial temporal lobe (MTL) structures. Patients with amnesia, who either had extensive MTL damage or damage that was relatively restricted to the hippocampus, were tested, as was a matched comparison group. Disproportionate relational memory impairments were predicted for both patient groups, and those with extensive MTL damage were also expected to have impaired item memory. Method Participants studied scenes, and were tested with interleaved two-alternative forced-choice probe trials. Probe trials were either presented immediately after the corresponding study trial (lag 1), five trials later (lag 5), or nine trials later (lag 9) and consisted of the studied scene along with a manipulated version of that scene in which one item was replaced with a different exemplar (item memory test) or was moved to a new location (relational memory test). Participants were to identify the exact match of the studied scene. Results As predicted, patients were disproportionately impaired on the test of relational memory. Item memory performance was marginally poorer among patients with extensive MTL damage, but both groups were impaired relative to matched comparison participants. Impaired performance was evident at all lags, including the shortest possible lag (lag 1). Conclusions The results are consistent with the proposed role of the hippocampus in relational memory binding and representation, even at short delays, and suggest that the hippocampus may also contribute to successful item memory when items are embedded in complex scenes. PMID:25068665

Animacy and real-world size shape object representations in the human medial temporal lobes.

PubMed

Blumenthal, Anna; Stojanoski, Bobby; Martin, Chris B; Cusack, Rhodri; Köhler, Stefan

2018-06-26

Identifying what an object is, and whether an object has been encountered before, is a crucial aspect of human behavior. Despite this importance, we do not yet have a complete understanding of the neural basis of these abilities. Investigations into the neural organization of human object representations have revealed category specific organization in the ventral visual stream in perceptual tasks. Interestingly, these categories fall within broader domains of organization, with reported distinctions between animate, inanimate large, and inanimate small objects. While there is some evidence for category specific effects in the medial temporal lobe (MTL), in particular in perirhinal and parahippocampal cortex, it is currently unclear whether domain level organization is also present across these structures. To this end, we used fMRI with a continuous recognition memory task. Stimuli were images of objects from several different categories, which were either animate or inanimate, or large or small within the inanimate domain. We employed representational similarity analysis (RSA) to test the hypothesis that object-evoked responses in MTL structures during recognition-memory judgments also show evidence for domain-level organization along both dimensions. Our data support this hypothesis. Specifically, object representations were shaped by either animacy, real-world size, or both, in perirhinal and parahippocampal cortex, and the hippocampus. While sensitivity to these dimensions differed across structures when probed individually, hinting at interesting links to functional differentiation, similarities in organization across MTL structures were more prominent overall. These results argue for continuity in the organization of object representations in the ventral visual stream and the MTL. © 2018 Wiley Periodicals, Inc.

Perception of front-of-pack labels according to social characteristics, nutritional knowledge and food purchasing habits.

PubMed

Méjean, Caroline; Macouillard, Pauline; Péneau, Sandrine; Hercberg, Serge; Castetbon, Katia

2013-03-01

To identify patterns of perception of front-of-pack (FOP) nutrition labels and to determine social factors, nutritional knowledge and attention to packaging features related to such patterns. Cross-sectional. Perception was measured using indicators of understanding and acceptability of three simple FOP labels (the 'Green Tick', the logo of the French Nutrition and Health Programme (PNNS logo) and 'simple traffic lights' (STL)) and two detailed formats ('multiple traffic lights' (MTL) and the 'colour range' logo (CR)). Associations of perception patterns with individual characteristics were examined using χ2 tests. Data from the French NutriNet-Santé cohort study. A total of 38,763 adults. Four perception patterns emerged. Poorly educated individuals were most often found in groups favouring simple formats. The 'favourable to CR' group had a high rate of men and older persons. Poor nutritional knowledge was more frequent in the 'favourable to STL' group, while individuals with substantial knowledge were proportionally more numerous in the 'favourable to MTL' group. The 'favourable to STL' group more frequently self-reported noting price and marketing characteristics during purchasing, while the 'favourable to MTL' and 'favourable to CR' groups declared more interest in nutritional information. The 'favourable to Green Tick and PNNS logo' group self-reported paying closer attention to claims and quality guarantee labels. The 'favourable to MTL' cluster was most frequently represented in our survey. However, simple FOP formats may be most appropriate for increasing awareness of healthy eating among targeted groups with poor nutritional knowledge and little interest in the nutritional quality of packaged foods.

Faces are special but not too special: Spared face recognition in amnesia is based on familiarity

PubMed Central

Aly, Mariam; Knight, Robert T.; Yonelinas, Andrew P.

2014-01-01

Most current theories of human memory are material-general in the sense that they assume that the medial temporal lobe (MTL) is important for retrieving the details of prior events, regardless of the specific type of materials. Recent studies of amnesia have challenged the material-general assumption by suggesting that the MTL may be necessary for remembering words, but is not involved in remembering faces. We examined recognition memory for faces and words in a group of amnesic patients, which included hypoxic patients and patients with extensive left or right MTL lesions. Recognition confidence judgments were used to plot receiver operating characteristics (ROCs) in order to more fully quantify recognition performance and to estimate the contributions of recollection and familiarity. Consistent with the extant literature, an analysis of overall recognition accuracy showed that the patients were impaired at word memory but had spared face memory. However, the ROC analysis indicated that the patients were generally impaired at high confidence recognition responses for faces and words, and they exhibited significant recollection impairments for both types of materials. Familiarity for faces was preserved in all patients, but extensive left MTL damage impaired familiarity for words. These results suggest that face recognition may appear to be spared because performance tends to rely heavily on familiarity, a process that is relatively well preserved in amnesia. The findings challenge material-general theories of memory, and suggest that both material and process are important determinants of memory performance in amnesia, and different types of materials may depend more or less on recollection and familiarity. PMID:20833190

Implicit perceptual-motor skill learning in mild cognitive impairment and Parkinson's disease.

PubMed

Gobel, Eric W; Blomeke, Kelsey; Zadikoff, Cindy; Simuni, Tanya; Weintraub, Sandra; Reber, Paul J

2013-05-01

Implicit skill learning is hypothesized to depend on nondeclarative memory that operates independent of the medial temporal lobe (MTL) memory system and instead depends on cortico striatal circuits between the basal ganglia and cortical areas supporting motor function and planning. Research with the Serial Reaction Time (SRT) task suggests that patients with memory disorders due to MTL damage exhibit normal implicit sequence learning. However, reports of intact learning rely on observations of no group differences, leading to speculation as to whether implicit sequence learning is fully intact in these patients. Patients with Parkinson's disease (PD) often exhibit impaired sequence learning, but this impairment is not universally observed. Implicit perceptual-motor sequence learning was examined using the Serial Interception Sequence Learning (SISL) task in patients with amnestic Mild Cognitive Impairment (MCI; n = 11) and patients with PD (n = 15). Sequence learning in SISL is resistant to explicit learning and individually adapted task difficulty controls for baseline performance differences. Patients with MCI exhibited robust sequence learning, equivalent to healthy older adults (n = 20), supporting the hypothesis that the MTL does not contribute to learning in this task. In contrast, the majority of patients with PD exhibited no sequence-specific learning in spite of matched overall task performance. Two patients with PD exhibited performance indicative of an explicit compensatory strategy suggesting that impaired implicit learning may lead to greater reliance on explicit memory in some individuals. The differences in learning between patient groups provides strong evidence in favor of implicit sequence learning depending solely on intact basal ganglia function with no contribution from the MTL memory system.

Stable expression of mtlD gene imparts multiple stress tolerance in finger millet.

PubMed

Hema, Ramanna; Vemanna, Ramu S; Sreeramulu, Shivakumar; Reddy, Chandrasekhara P; Senthil-Kumar, Muthappa; Udayakumar, Makarla

2014-01-01

Finger millet is susceptible to abiotic stresses, especially drought and salinity stress, in the field during seed germination and early stages of seedling development. Therefore developing stress tolerant finger millet plants combating drought, salinity and associated oxidative stress in these two growth stages is important. Cellular protection through osmotic adjustment and efficient free radical scavenging ability during abiotic stress are important components of stress tolerance mechanisms in plants. Mannitol, an osmolyte, is known to scavenge hydroxyl radicals generated during various abiotic stresses and thereby minimize stress damage in several plant species. In this study transgenic finger millet plants expressing the mannitol biosynthetic pathway gene from bacteria, mannitol-1-phosphate dehydrogenase (mtlD), were developed through Agrobacterium tumefaciens-mediated genetic transformation. mtlD gene integration in the putative transgenic plants was confirmed by Southern blot. Further, performance of transgenic finger millet under drought, salinity and oxidative stress was studied at plant level in T1 generation and in T1 and T2 generation seedlings. Results from these experiments showed that transgenic finger millet had better growth under drought and salinity stress compared to wild-type. At plant level, transgenic plants showed better osmotic adjustment and chlorophyll retention under drought stress compared to the wild-type. However, the overall increase in stress tolerance of transgenics for the three stresses, especially for oxidative stress, was only marginal compared to other mtlD gene expressing plant species reported in the literature. Moreover, the Agrobacterium-mediated genetic transformation protocol developed for finger millet in this study can be used to introduce diverse traits of agronomic importance in finger millet.

[Clinical Feature in Infants of Breast Feeding Allergy and Its Possible Relation with Gastrointestinal Peptide Change in Breast Milk].

PubMed

Xie, Yong-Mei; Gao, Shan; Wang, Li-Yuan; Wang, Zhi-Ling; Cai, Xiao-Tang; Zhou, Hui

2017-01-01

To investigate clinical features in infants of breast milk allergy(BMA), and the possible relationship with the changes of somatostatin (SST) and motilin (MTL) in breast milk. Twenty three cases of pure breast feeding infants with allergic gastroenteritis were collected, while another 23 normal infants with pure breast feeding were enrolled as normal controls. Samples of infant stools and breast milk were collected for the measurement of SST and MTL levels detected by by radioimmunity. The levels of SST and MTL in stool samples (pg/mg) were 32.6±8.9, 2.3±3.7 in BMA group and 56.2±12.7, 21.6±4.7 in normal control group, respectively. Those in breast milk (pg/mg) were 236.7±28.9, 159.4±36.7 in BMA group and 412.6±36.7, 216.8±59.7 in normal control group, respectively. All the differences were statistically significant ( P <0.05). In BMA infants, the clinical features were 91.3% (20/23) of diarrhea, 86.9% (21/23) of vomiting, 69.6% (16/23) of hematochezia, 95.7% (22/23) of C-reactive protein (CRP) increasing, 87.0% (20/23) of occult blood in stools, 73.9% (17/23) of neutrophil increasing, 39.1% (9/23) of WBC in stools. For those infants of breast feeding with persisting and repeated gastrointestinal symptoms, allergy for breast milk should be considered. Deficiency of SST and MTL in breast milk may be a possible cause for food allergy.

The human brain representation of odor identification.

PubMed

Kjelvik, Grete; Evensmoen, Hallvard R; Brezova, Veronika; Håberg, Asta K

2012-07-01

Odor identification (OI) tests are increasingly used clinically as biomarkers for Alzheimer's disease and schizophrenia. The aim of this study was to directly compare the neuronal correlates to identified odors vs. nonidentified odors. Seventeen females with normal olfactory function underwent a functional magnetic resonance imaging (fMRI) experiment with postscanning assessment of spontaneous uncued OI. An event-related analysis was performed to compare within-subject activity to spontaneously identified vs. nonidentified odors at the whole brain level, and in anatomic and functional regions of interest (ROIs) in the medial temporal lobe (MTL). Parameter estimate values and blood oxygenated level-dependent (BOLD) signal curves for correctly identified and nonidentified odors were derived from functional ROIs in hippocampus, entorhinal, piriform, and orbitofrontal cortices. Number of activated voxels and max parameter estimate values were obtained from anatomic ROIs in the hippocampus and the entorhinal cortex. At the whole brain level the correct OI gave rise to increased activity in the left entorhinal cortex and secondary olfactory structures, including the orbitofrontal cortex. Increased activation was also observed in fusiform, primary visual, and auditory cortices, inferior frontal plus inferior temporal gyri. The anatomic MTL ROI analysis showed increased activation in the left entorhinal cortex, right hippocampus, and posterior parahippocampal gyri in correct OI. In the entorhinal cortex and hippocampus the BOLD signal increased specifically in response to identified odors and decreased for nonidentified odors. In orbitofrontal and piriform cortices both identified and nonidentified odors gave rise to an increased BOLD signal, but the response to identified odors was significantly greater than that for nonidentified odors. These results support a specific role for entorhinal cortex and hippocampus in OI, whereas piriform and orbitofrontal cortices are active in both smelling and OI. Moreover, episodic as well as semantic memory systems appeared to support OI.

Efficient mannitol production by wild-type Lactobacillus reuteri CRL 1101 is attained at constant pH using a simplified culture medium.

PubMed

Ortiz, Maria Eugenia; Raya, Raúl R; Mozzi, Fernanda

2015-10-01

Mannitol is a natural polyol with multiple industrial applications. In this work, mannitol production by Lactobacillus reuteri CRL 1101 was studied at free- and controlled-pH (6.0-4.8) fermentations using a simplified culture medium containing yeast and beef extracts and sugarcane molasses. The activity of mannitol 2-dehydrogenase (MDH), the enzyme responsible for mannitol synthesis, was determined. The effect of the initial biomass concentration was further studied. Mannitol production (41.5 ± 1.1 g/l), volumetric productivity (Q Mtl 1.73 ± 0.05 g/l h), and yield (Y Mtl 105 ± 11 %) were maximum at pH 5.0 after 24 h while the highest MDH activity (1.66 ± 0.09 U/mg protein) was obtained at pH 6.0. No correlation between mannitol production and MDH activity was observed when varying the culture pH. The increase (up to 2000-fold) in the initial biomass concentration did not improve mannitol formation after 24 h although a 2-fold higher amount was produced at 8 h using 1 or 2 g cell dry weight/l comparing to the control (0.001 g cell dry weight/l). Finally, mannitol isolation under optimum fermentation conditions was achieved. The mannitol production obtained in this study is the highest reported so far by a wild-type L. reuteri strain and, more interestingly, using a simplified culture medium.

Preventive effect of Dendrobium candidum Wall. ex Lindl. on activated carbon-induced constipation in mice

PubMed Central

WANG, RUI; SUN, PENG; ZHOU, YALIN; ZHAO, XIN

2015-01-01

The aim of this study was to investigate the effects of Dendrobium candidum Wall. ex Lindl. (D. candidum) on activated carbon-induced constipation in ICR mice. ICR mice were orally administered D. candidum for 9 days. Body weight, defecation status, gastrointestinal (GI) transit and defecation times, in addition to the levels of motilin (MTL), gastrin (Gas), endothelin (ET), somatostatin (SS), acetylcholinesterase (AChE), substance P (SP) and vasoactive intestinal peptide (VIP) in serum were used to evaluate the preventive effects of D. candidum on constipation. The laxative drug bisacodyl acted as a positive control. The time to the first defecation of a black stool for the normal, control, bisacodyl-treated (100 mg/kg), 200 and 400 mg/kg D. candidum-treated mice was 84, 202, 126, 161 and 142 min, respectively. Following the consumption of 200 and 400 mg/kg D. candidum or bisacodyl (100 mg/kg), the GI transit was reduced to 57.7, 74.6 and 90.2%, respectively, of the transit in normal mice. The serum levels of MTL, Gas, ET, AChE, SP and VIP were significantly increased and the serum levels of SS were reduced in the mice treated with D. candidum compared with those in the untreated control mice (P<0.05). These results demonstrate that D. candidum has preventive effects on constipation in mice, and a greater functional activity was observed when a higher concentration was administered. PMID:25574235

Similar patterns of neural activity predict memory function during encoding and retrieval.

PubMed

Kragel, James E; Ezzyat, Youssef; Sperling, Michael R; Gorniak, Richard; Worrell, Gregory A; Berry, Brent M; Inman, Cory; Lin, Jui-Jui; Davis, Kathryn A; Das, Sandhitsu R; Stein, Joel M; Jobst, Barbara C; Zaghloul, Kareem A; Sheth, Sameer A; Rizzuto, Daniel S; Kahana, Michael J

2017-07-15

Neural networks that span the medial temporal lobe (MTL), prefrontal cortex, and posterior cortical regions are essential to episodic memory function in humans. Encoding and retrieval are supported by the engagement of both distinct neural pathways across the cortex and common structures within the medial temporal lobes. However, the degree to which memory performance can be determined by neural processing that is common to encoding and retrieval remains to be determined. To identify neural signatures of successful memory function, we administered a delayed free-recall task to 187 neurosurgical patients implanted with subdural or intraparenchymal depth electrodes. We developed multivariate classifiers to identify patterns of spectral power across the brain that independently predicted successful episodic encoding and retrieval. During encoding and retrieval, patterns of increased high frequency activity in prefrontal, MTL, and inferior parietal cortices, accompanied by widespread decreases in low frequency power across the brain predicted successful memory function. Using a cross-decoding approach, we demonstrate the ability to predict memory function across distinct phases of the free-recall task. Furthermore, we demonstrate that classifiers that combine information from both encoding and retrieval states can outperform task-independent models. These findings suggest that the engagement of a core memory network during either encoding or retrieval shapes the ability to remember the past, despite distinct neural interactions that facilitate encoding and retrieval. Copyright © 2017 Elsevier Inc. All rights reserved.

Getting the word out: neural correlates of enthusiastic message propagation.

PubMed

Falk, Emily B; O'Donnell, Matthew Brook; Lieberman, Matthew D

2012-01-01

What happens in the mind of a person who first hears a potentially exciting idea?We examined the neural precursors of spreading ideas with enthusiasm, and dissected enthusiasm into component processes that can be identified through automated linguistic analysis, gestalt human ratings of combined linguistic and non-verbal cues, and points of convergence/divergence between the two. We combined tools from natural language processing (NLP) with data gathered using fMRI to link the neurocognitive mechanisms that are set in motion during initial exposure to ideas and subsequent behaviors of these message communicators outside of the scanner. Participants' neural activity was recorded as they reviewed ideas for potential television show pilots. Participants' language from video-taped interviews collected post-scan was transcribed and given to an automated linguistic sentiment analysis (SA) classifier, which returned ratings for evaluative language (evaluative vs. descriptive) and valence (positive vs. negative). Separately, human coders rated the enthusiasm with which participants transmitted each idea. More positive sentiment ratings by the automated classifier were associated with activation in neural regions including medial prefrontal cortex; MPFC, precuneus/posterior cingulate cortex; PC/PCC, and medial temporal lobe; MTL. More evaluative, positive, descriptions were associated exclusively with neural activity in temporal-parietal junction (TPJ). Finally, human ratings indicative of more enthusiastic sentiment were associated with activation across these regions (MPFC, PC/PCC, DMPFC, TPJ, and MTL) as well as in ventral striatum (VS), inferior parietal lobule and premotor cortex. Taken together, these data demonstrate novel links between neural activity during initial idea encoding and the enthusiasm with which the ideas are subsequently delivered. This research lays the groundwork to use machine learning and neuroimaging data to study word of mouth communication and the spread of ideas in both traditional and new media environments.

Getting the word out: neural correlates of enthusiastic message propagation

PubMed Central

Falk, Emily B.; O'Donnell, Matthew Brook; Lieberman, Matthew D.

2012-01-01

What happens in the mind of a person who first hears a potentially exciting idea?We examined the neural precursors of spreading ideas with enthusiasm, and dissected enthusiasm into component processes that can be identified through automated linguistic analysis, gestalt human ratings of combined linguistic and non-verbal cues, and points of convergence/divergence between the two. We combined tools from natural language processing (NLP) with data gathered using fMRI to link the neurocognitive mechanisms that are set in motion during initial exposure to ideas and subsequent behaviors of these message communicators outside of the scanner. Participants' neural activity was recorded as they reviewed ideas for potential television show pilots. Participants' language from video-taped interviews collected post-scan was transcribed and given to an automated linguistic sentiment analysis (SA) classifier, which returned ratings for evaluative language (evaluative vs. descriptive) and valence (positive vs. negative). Separately, human coders rated the enthusiasm with which participants transmitted each idea. More positive sentiment ratings by the automated classifier were associated with activation in neural regions including medial prefrontal cortex; MPFC, precuneus/posterior cingulate cortex; PC/PCC, and medial temporal lobe; MTL. More evaluative, positive, descriptions were associated exclusively with neural activity in temporal-parietal junction (TPJ). Finally, human ratings indicative of more enthusiastic sentiment were associated with activation across these regions (MPFC, PC/PCC, DMPFC, TPJ, and MTL) as well as in ventral striatum (VS), inferior parietal lobule and premotor cortex. Taken together, these data demonstrate novel links between neural activity during initial idea encoding and the enthusiasm with which the ideas are subsequently delivered. This research lays the groundwork to use machine learning and neuroimaging data to study word of mouth communication and the spread of ideas in both traditional and new media environments. PMID:23189049

Discovery of Dual-Action Membrane-Anchored Modulators of Incretin Receptors

PubMed Central

Fortin, Jean-Philippe; Chinnapen, Daniel; Beinborn, Martin; Lencer, Wayne; Kopin, Alan S.

2011-01-01

Background The glucose-dependent insulinotropic polypeptide (GIP) and the glucagon-like peptide-1 (GLP-1) receptors are considered complementary therapeutic targets for type 2 diabetes. Using recombinant membrane-tethered ligand (MTL) technology, the present study focused on defining optimized modulators of these receptors, as well as exploring how local anchoring influences soluble peptide function. Methodology/Principal Findings Serial substitution of residue 7 in membrane-tethered GIP (tGIP) led to a wide range of activities at the GIP receptor, with [G7]tGIP showing enhanced efficacy compared to the wild type construct. In contrast, introduction of G7 into the related ligands, tGLP-1 and tethered exendin-4 (tEXE4), did not affect signaling at the cognate GLP-1 receptor. Both soluble and tethered GIP and GLP-1 were selective activators of their respective receptors. Although soluble EXE4 is highly selective for the GLP-1 receptor, unexpectedly, tethered EXE4 was found to be a potent activator of both the GLP-1 and GIP receptors. Diverging from the pharmacological properties of soluble and tethered GIP, the newly identified GIP-R agonists, (i.e. [G7]tGIP and tEXE4) failed to trigger cognate receptor endocytosis. In an attempt to recapitulate the dual agonism observed with tEXE4, we conjugated soluble EXE4 to a lipid moiety. Not only did this soluble peptide activate both the GLP-1 and GIP receptors but, when added to receptor expressing cells, the activity persists despite serial washes. Conclusions These findings suggest that conversion of a recombinant MTL to a soluble membrane anchored equivalent offers a means to prolong ligand function, as well as to design agonists that can simultaneously act on more than one therapeutic target. PMID:21935440

An fMRI investigation of the fronto-striatal learning system in women who exhibit eating disorder behaviors

PubMed Central

Celone, Kim A.; Thompson-Brenner, Heather; Ross, Robert S.; Pratt, Elizabeth M.; Stern, Chantal E.

2013-01-01

In the present study, we sought to examine whether the fronto-striatal learning system, which has been implicated in bulimia nervosa, would demonstrate altered BOLD activity during probabilistic category learning in women who met subthreshold criteria for bulimia nervosa (Sub-BN). Sub-BN, which falls within the clinical category of Eating Disorder Not Otherwise Specified (EDNOS), is comprised of individuals who demonstrate recurrent binge eating, efforts to minimize their caloric intake and caloric retention, and elevated levels of concern about shape, weight, and/or eating, but just fail to meet the diagnostic threshold for bulimia nervosa (BN). fMRI data were collected from eighteen women with subthreshold-BN (Sub-BN) and nineteen healthy control women group-matched for age, education and body mass index (MC) during the weather prediction task. Sub-BN participants demonstrated increased caudate nucleus and dorsolateral prefrontal cortex (DLPFC) activation during the learning of probabilistic categories. Though the two subject groups did not differ in behavioral performance, over the course of learning, Sub-BN participants showed a dynamic pattern of brain activity differences when compared to matched control participants. Regions implicated in episodic memory, including the medial temporal lobe (MTL), retrosplenial cortex, middle frontal gyrus, and anterior and posterior cingulate cortex showed decreased activity in the Sub-BN participants compared to MCs during early learning which was followed by increased involvement of the DLPFC during later learning. These findings demonstrate that women with Sub-BN demonstrate differences in fronto-striatal learning system activity, as well as a distinct functional pattern between fronto-striatal and MTL learning systems during the course of implicit probabilistic category learning. PMID:21419229

Automatic Scoring of Multiple Semantic Attributes With Multi-Task Feature Leverage: A Study on Pulmonary Nodules in CT Images.

PubMed

Sihong Chen; Jing Qin; Xing Ji; Baiying Lei; Tianfu Wang; Dong Ni; Jie-Zhi Cheng

2017-03-01

The gap between the computational and semantic features is the one of major factors that bottlenecks the computer-aided diagnosis (CAD) performance from clinical usage. To bridge this gap, we exploit three multi-task learning (MTL) schemes to leverage heterogeneous computational features derived from deep learning models of stacked denoising autoencoder (SDAE) and convolutional neural network (CNN), as well as hand-crafted Haar-like and HoG features, for the description of 9 semantic features for lung nodules in CT images. We regard that there may exist relations among the semantic features of "spiculation", "texture", "margin", etc., that can be explored with the MTL. The Lung Image Database Consortium (LIDC) data is adopted in this study for the rich annotation resources. The LIDC nodules were quantitatively scored w.r.t. 9 semantic features from 12 radiologists of several institutes in U.S.A. By treating each semantic feature as an individual task, the MTL schemes select and map the heterogeneous computational features toward the radiologists' ratings with cross validation evaluation schemes on the randomly selected 2400 nodules from the LIDC dataset. The experimental results suggest that the predicted semantic scores from the three MTL schemes are closer to the radiologists' ratings than the scores from single-task LASSO and elastic net regression methods. The proposed semantic attribute scoring scheme may provide richer quantitative assessments of nodules for better support of diagnostic decision and management. Meanwhile, the capability of the automatic association of medical image contents with the clinical semantic terms by our method may also assist the development of medical search engine.

Implicit Perceptual-Motor Skill Learning in Mild Cognitive Impairment and Parkinson's Disease

PubMed Central

Gobel, Eric W.; Blomeke, Kelsey; Zadikoff, Cindy; Simuni, Tanya; Weintraub, Sandy; Reber, Paul J.

2015-01-01

Objective Implicit skill learning is hypothesized to depend on nondeclarative memory that operates independent of the medial temporal lobe (MTL) memory system and instead depends on cortico-striatal circuits between the basal ganglia and cortical areas supporting motor function and planning. Research with the Serial Reaction Time (SRT) task suggests that patients with memory-disorders due to MTL damage exhibit normal implicit sequence learning. However, reports of intact learning rely on observations of no group differences, leading to speculation whether implicit sequence learning is fully intact in these patients. Patients with Parkinson's Disease (PD) often exhibit impaired sequence learning, but this impairment is not universally observed. Method Implicit perceptual-motor sequence learning was examined using the Serial Interception Sequence Learning (SISL) task in patients with amnestic Mild Cognitive Impairment (MCI; n=11) and patients with PD (n=15). Sequence learning in SISL is resistant to explicit learning and individually adapted task difficulty controls for baseline performance differences. Results Patients with MCI exhibited robust sequence learning, equivalent to healthy older adults (n=20), supporting the hypothesis that the MTL does not contribute to learning in this task. In contrast, the majority of patients with PD exhibited no sequence-specific learning in spite of matched overall task performance. Two patients with PD exhibited performance indicative of an explicit compensatory strategy suggesting that impaired implicit learning may lead to greater reliance on explicit memory in some individuals. Conclusion The differences in learning between patient groups provides strong evidence in favor of implicit sequence learning depending solely on intact basal ganglia function with no contribution from the MTL memory system. PMID:23688213

Stable Expression of mtlD Gene Imparts Multiple Stress Tolerance in Finger Millet

PubMed Central

Hema, Ramanna; Vemanna, Ramu S.; Sreeramulu, Shivakumar; Reddy, Chandrasekhara P.; Senthil-Kumar, Muthappa; Udayakumar, Makarla

2014-01-01

Finger millet is susceptible to abiotic stresses, especially drought and salinity stress, in the field during seed germination and early stages of seedling development. Therefore developing stress tolerant finger millet plants combating drought, salinity and associated oxidative stress in these two growth stages is important. Cellular protection through osmotic adjustment and efficient free radical scavenging ability during abiotic stress are important components of stress tolerance mechanisms in plants. Mannitol, an osmolyte, is known to scavenge hydroxyl radicals generated during various abiotic stresses and thereby minimize stress damage in several plant species. In this study transgenic finger millet plants expressing the mannitol biosynthetic pathway gene from bacteria, mannitol-1-phosphate dehydrogenase (mtlD), were developed through Agrobacterium tumefaciens-mediated genetic transformation. mtlD gene integration in the putative transgenic plants was confirmed by Southern blot. Further, performance of transgenic finger millet under drought, salinity and oxidative stress was studied at plant level in T1 generation and in T1 and T2 generation seedlings. Results from these experiments showed that transgenic finger millet had better growth under drought and salinity stress compared to wild-type. At plant level, transgenic plants showed better osmotic adjustment and chlorophyll retention under drought stress compared to the wild-type. However, the overall increase in stress tolerance of transgenics for the three stresses, especially for oxidative stress, was only marginal compared to other mtlD gene expressing plant species reported in the literature. Moreover, the Agrobacterium-mediated genetic transformation protocol developed for finger millet in this study can be used to introduce diverse traits of agronomic importance in finger millet. PMID:24922513

Age-related functional changes in domain-specific medial temporal lobe pathways.

PubMed

Berron, David; Neumann, Katja; Maass, Anne; Schütze, Hartmut; Fliessbach, Klaus; Kiven, Verena; Jessen, Frank; Sauvage, Magdalena; Kumaran, Dharshan; Düzel, Emrah

2018-05-01

There is now converging evidence from studies in animals and humans that the medial temporal lobes (MTLs) harbor anatomically distinct processing pathways for object and scene information. Recent functional magnetic resonance imaging studies in humans suggest that this domain-specific organization may be associated with a functional preference of the anterior-lateral part of the entorhinal cortex (alErC) for objects and the posterior-medial entorhinal cortex (pmErC) for scenes. As MTL subregions are differentially affected by aging and neurodegenerative diseases, the question was raised whether aging may affect the 2 pathways differentially. To address this possibility, we developed a paradigm that allows the investigation of object memory and scene memory in a mnemonic discrimination task. A group of young (n = 43) and healthy older subjects (n = 44) underwent functional magnetic resonance imaging recordings during this novel task, while they were asked to discriminate exact repetitions of object and scene stimuli from novel stimuli that were similar but modified versions of the original stimuli ("lures"). We used structural magnetic resonance images to manually segment anatomical components of the MTL including alErC and pmErC and used these segmented regions to analyze domain specificity of functional activity. Across the entire sample, object processing was associated with activation of the perirhinal cortex (PrC) and alErC, whereas for scene processing, activation was more predominant in the parahippocampal cortex and pmErC. Functional activity related to mnemonic discrimination of object and scene lures from exact repetitions was found to overlap between processing pathways and suggests that while the PrC-alErC pathway was more involved in object discrimination, both pathways were involved in the discrimination of similar scenes. Older adults were behaviorally less accurate than young adults in discriminating similar lures from exact repetitions, but this reduction was equivalent in both domains. However, this was accompanied by significantly reduced domain-specific activity in PrC in older adults compared to what was observed in the young. Furthermore, this reduced domain-specific activity was associated to worse performance in object mnemonic discrimination in older adults. Taken together, we show the fine-grained functional organization of the MTL into domain-specific pathways for objects and scenes and their mnemonic discrimination and further provide evidence that aging might affect these pathways in a differential fashion. Future experiments will elucidate whether the 2 pathways are differentially affected in early stages of Alzheimer's disease in relation to amyloid or tau pathology. Copyright © 2018 The Author(s). Published by Elsevier Inc. All rights reserved.

An update of Quaternary faults of central and eastern Oregon

USGS Publications Warehouse

Weldon, Ray J.; Fletcher, D.K.; Weldon, E.M.; Scharer, K.M.; McCrory, P.A.

2002-01-01

This is the online version of a CD-ROM publication. We have updated the eastern portion of our previous active fault map of Oregon (Pezzopane, Nakata, and Weldon, 1992) as a contribution to the larger USGS effort to produce digital maps of active faults in the Pacific Northwest region. The 1992 fault map has seen wide distribution and has been reproduced in essentially all subsequent compilations of active faults of Oregon. The new map provides a substantial update of known active or suspected active faults east of the Cascades. Improvements in the new map include (1) many newly recognized active faults, (2) a linked ArcInfo map and reference database, (3) more precise locations for previously recognized faults on shaded relief quadrangles generated from USGS 30-m digital elevations models (DEM), (4) more uniform coverage resulting in more consistent grouping of the ages of active faults, and (5) a new category of 'possibly' active faults that share characteristics with known active faults, but have not been studied adequately to assess their activity. The distribution of active faults has not changed substantially from the original Pezzopane, Nakata and Weldon map. Most faults occur in the south-central Basin and Range tectonic province that is located in the backarc portion of the Cascadia subduction margin. These faults occur in zones consisting of numerous short faults with similar rates, ages, and styles of movement. Many active faults strongly correlate with the most active volcanic centers of Oregon, including Newberry Craters and Crater Lake.

Rumination and Default Mode Network Subsystems Connectivity in First-episode, Drug-Naive Young Patients with Major Depressive Disorder

PubMed Central

Zhu, Xueling; Zhu, Qiuling; Shen, Huaizhen; Liao, Weihua; Yuan, Fulai

2017-01-01

Neuroimaging evidence implicates the association between rumination and default mode network (DMN) in major depressive disorder (MDD). However, the relationship between rumination and DMN subsystems remains incompletely understood, especially in patients with MDD. Thirty-three first-episode drug-naive patients with MDD and thirty-three healthy controls (HCs) were enrolled and underwent resting-sate fMRI scanning. Functional connectivity analysis was performed based on 11 pre-defined regions of interest (ROIs) for three DMN subsystems: the midline core, dorsal medial prefrontal cortex (dMPFC) and medial temporal lobe (MTL). Compared with HCs group, patients with MDD exhibited increased within-system connectivity in the dMPFC subsystem and inter-system connectivity between the dMPFC and MTL subsystems. Decreased inter-system connectivity was identified between the midline core and dMPFC subsystem in MDD patients. Depressive rumination was positively correlated with within-system connectivity in the dMPFC subsystem (dMPFC-TempP) and with inter-system connectivity between the dMPFC and MTL subsystems (LTC-PHC). Our results suggest MDD may be characterized by abnormal DMN subsystems connectivity, which may contribute to the pathophysiology of the maladaptive self-focus in MDD patients. PMID:28225084

Medial temporal lobe roles in human path integration.

PubMed

Yamamoto, Naohide; Philbeck, John W; Woods, Adam J; Gajewski, Daniel A; Arthur, Joeanna C; Potolicchio, Samuel J; Levy, Lucien; Caputy, Anthony J

2014-01-01

Path integration is a process in which observers derive their location by integrating self-motion signals along their locomotion trajectory. Although the medial temporal lobe (MTL) is thought to take part in path integration, the scope of its role for path integration remains unclear. To address this issue, we administered a variety of tasks involving path integration and other related processes to a group of neurosurgical patients whose MTL was unilaterally resected as therapy for epilepsy. These patients were unimpaired relative to neurologically intact controls in many tasks that required integration of various kinds of sensory self-motion information. However, the same patients (especially those who had lesions in the right hemisphere) walked farther than the controls when attempting to walk without vision to a previewed target. Importantly, this task was unique in our test battery in that it allowed participants to form a mental representation of the target location and anticipate their upcoming walking trajectory before they began moving. Thus, these results put forth a new idea that the role of MTL structures for human path integration may stem from their participation in predicting the consequences of one's locomotor actions. The strengths of this new theoretical viewpoint are discussed.

VL: a further case of erroneous recollection.

PubMed

Craik, Fergus I M; Barense, Morgan D; Rathbone, Clare J; Grusec, Joan E; Stuss, Donald T; Gao, Fuqiang; Scott, Christopher J M; Black, Sandra E

2014-04-01

We report a single-case study of a female patient (VL) who exhibited frequent episodes of erroneous recollections triggered by everyday events. Based on neuropsychological testing, VL was classified as suffering from mild to moderate dementia (MMSE=18) and was given a diagnosis of probable Alzheimer׳s disease. Her memory functions were uniformly impaired but her verbal abilities were generally well preserved. A structural MRI scan showed extensive areas of gray matter atrophy particularly in frontal and medial-temporal (MTL) areas. Results of experimental recognition tests showed that VL had very high false alarm rates on tests using pictures, faces and auditory stimuli, but lower false alarm rates on verbal tests. We provide a speculative account of her erroneous recollections in terms of her MTL and frontal pathology. In outline, we suggest that owing to binding failures in MTL regions, VL׳s recognition processes were forced to rely on earlier than normal stages of analysis. Environmental features on a given recognition trial may have combined with fragments persisting from previous trials resulting in erroneous feelings of familiarity and of recollection that were not discounted or edited out, due to her impaired frontal processes. Crown Copyright © 2014. Published by Elsevier Ltd. All rights reserved.

Insulin Resistance Predicts Medial Temporal Hypermetabolism in Mild Cognitive Impairment Conversion to Alzheimer Disease

PubMed Central

Willette, Auriel A.; Modanlo, Nina

2015-01-01

Alzheimer disease (AD) is characterized by progressive hypometabolism on [18F]-fluorodeoxyglucose positron emission tomography (FDG-PET) scans. Peripheral insulin resistance (IR) increases AD risk. No studies have examined associations between FDG metabolism and IR in mild cognitive impairment (MCI) and AD, as well as MCI conversion to AD. We studied 26 cognitively normal (CN), 194 MCI (39 MCI-progressors, 148 MCI-stable, 2 years after baseline), and 60 AD subjects with baseline FDG-PET from the Alzheimer’s Disease Neuroimaging Initiative. Mean FDG metabolism was derived for AD-vulnerable regions of interest (ROIs), including lateral parietal and posteromedial cortices, medial temporal lobe (MTL), hippocampus, and ventral prefrontal cortices (vPFC), as well as postcentral gyrus and global cerebrum control regions. The homeostasis model assessment of IR (HOMA-IR) was used to measure IR. For AD, higher HOMA-IR predicted lower FDG in all ROIs. For MCI-progressors, higher HOMA-IR predicted higher FDG in the MTL and hippocampus. Control regions showed no associations. Higher HOMA-IR predicted hypermetabolism in MCI-progressors and hypometabolism in AD in medial temporal regions. Future longitudinal studies should examine the pathophysiologic significance of the shift from MTL hyper- to hypometabolism associated with IR. PMID:25576061

Medial Temporal Lobe Roles in Human Path Integration

PubMed Central

Yamamoto, Naohide; Philbeck, John W.; Woods, Adam J.; Gajewski, Daniel A.; Arthur, Joeanna C.; Potolicchio, Samuel J.; Levy, Lucien; Caputy, Anthony J.

2014-01-01

Path integration is a process in which observers derive their location by integrating self-motion signals along their locomotion trajectory. Although the medial temporal lobe (MTL) is thought to take part in path integration, the scope of its role for path integration remains unclear. To address this issue, we administered a variety of tasks involving path integration and other related processes to a group of neurosurgical patients whose MTL was unilaterally resected as therapy for epilepsy. These patients were unimpaired relative to neurologically intact controls in many tasks that required integration of various kinds of sensory self-motion information. However, the same patients (especially those who had lesions in the right hemisphere) walked farther than the controls when attempting to walk without vision to a previewed target. Importantly, this task was unique in our test battery in that it allowed participants to form a mental representation of the target location and anticipate their upcoming walking trajectory before they began moving. Thus, these results put forth a new idea that the role of MTL structures for human path integration may stem from their participation in predicting the consequences of one's locomotor actions. The strengths of this new theoretical viewpoint are discussed. PMID:24802000

Multimodal neuroimaging evidence linking memory and attention systems during visual search cued by context.

PubMed

Kasper, Ryan W; Grafton, Scott T; Eckstein, Miguel P; Giesbrecht, Barry

2015-03-01

Visual search can be facilitated by the learning of spatial configurations that predict the location of a target among distractors. Neuropsychological and functional magnetic resonance imaging (fMRI) evidence implicates the medial temporal lobe (MTL) memory system in this contextual cueing effect, and electroencephalography (EEG) studies have identified the involvement of visual cortical regions related to attention. This work investigated two questions: (1) how memory and attention systems are related in contextual cueing; and (2) how these systems are involved in both short- and long-term contextual learning. In one session, EEG and fMRI data were acquired simultaneously in a contextual cueing task. In a second session conducted 1 week later, EEG data were recorded in isolation. The fMRI results revealed MTL contextual modulations that were correlated with short- and long-term behavioral context enhancements and attention-related effects measured with EEG. An fMRI-seeded EEG source analysis revealed that the MTL contributed the most variance to the variability in the attention enhancements measured with EEG. These results support the notion that memory and attention systems interact to facilitate search when spatial context is implicitly learned. © 2015 New York Academy of Sciences.

Implementation of a Water Flow Control System into the ISS'S Planned Fluids & Combustion Facility

NASA Technical Reports Server (NTRS)

Edwards, Daryl A.

2003-01-01

The Fluids and Combustion Facility (FCF) will become an ISS facility capable of performing basic combustion and fluids research. The facility consists of two independent payload racks specifically configured to support multiple experiments over the life of the ISS. Both racks will depend upon the ISS's Moderate Temperature Loop (MTL) for removing waste heat generated by the avionics and experiments operating within the racks. By using the MTL, constraints are imposed by the ISS vehicle on how the coolant resource is used. On the other hand, the FCF depends upon effective thermal control for maximizing life of the hardware and for supplying proper boundary conditions for the experiments. In the implementation of a design solution, significant factors in the selection of the hardware included ability to measure and control relatively low flow rates, ability to throttle flow within the time constraints of the ISS MTL, conserve energy usage, observe low mass and small volume requirements. An additional factor in the final design solution selection was considering how the system would respond to a loss of power event. This paper describes the method selected to satisfy the FCF design requirements while maintaining the constraints applied by the ISS vehicle.

Designing monitoring programs for chemicals of emerging concern in potable reuse--what to include and what not to include?

PubMed

Drewes, J E; Anderson, P; Denslow, N; Olivieri, A; Schlenk, D; Snyder, S A; Maruya, K A

2013-01-01

This study discussed a proposed process to prioritize chemicals for reclaimed water monitoring programs, selection of analytical methods required for their quantification, toxicological relevance of chemicals of emerging concern regarding human health, and related issues. Given that thousands of chemicals are potentially present in reclaimed water and that information about those chemicals is rapidly evolving, a transparent, science-based framework was developed to guide prioritization of which compounds of emerging concern (CECs) should be included in reclaimed water monitoring programs. The recommended framework includes four steps: (1) compile environmental concentrations (e.g., measured environmental concentration or MEC) of CECs in the source water for reuse projects; (2) develop a monitoring trigger level (MTL) for each of these compounds (or groups thereof) based on toxicological relevance; (3) compare the environmental concentration (e.g., MEC) to the MTL; CECs with a MEC/MTL ratio greater than 1 should be prioritized for monitoring, compounds with a ratio less than '1' should only be considered if they represent viable treatment process performance indicators; and (4) screen the priority list to ensure that a commercially available robust analytical method is available for that compound.

Contributions of Feature Binding During Encoding and Functional Connectivity of the Medial Temporal Lobe Structures to Episodic Memory Deficits Across the Prodromal and First-Episode Phases of Schizophrenia

PubMed Central

Haut, Kristen M.; van Erp, Theo G. M.; Knowlton, Barbara; Bearden, Carrie E.; Subotnik, Kenneth; Ventura, Joseph; Nuechterlein, Keith H.; Cannon, Tyrone D.

2014-01-01

Patients with and at risk for psychosis may have difficulty using associative strategies to facilitate episodic memory encoding and recall. In parallel studies, patients with first-episode schizophrenia (n = 27) and high psychosis risk (n = 28) compared with control participants (n = 22 and n = 20, respectively) underwent functional MRI during a remember-know memory task. Psychophysiological interaction analyses, using medial temporal lobe (MTL) structures as regions of interest, were conducted to measure functional connectivity patterns supporting successful episodic memory. During encoding, patients with first-episode schizophrenia demonstrated reduced functional coupling between MTL regions and regions involved in stimulus representations, stimulus selection, and cognitive control. Relative to control participants and patients with high psychosis risk who did not convert to psychosis, patients with high psychosis risk who later converted to psychosis also demonstrated reduced connectivity between MTL regions and auditory-verbal and visual-association regions. These results suggest that episodic memory deficits in schizophrenia are related to inefficient recruitment of cortical connections involved in associative memory formation; such deficits precede the onset of psychosis among those individuals at high clinical risk. PMID:25750836

Contributions of Feature Binding During Encoding and Functional Connectivity of the Medial Temporal Lobe Structures to Episodic Memory Deficits Across the Prodromal and First-Episode Phases of Schizophrenia.

PubMed

Haut, Kristen M; van Erp, Theo G M; Knowlton, Barbara; Bearden, Carrie E; Subotnik, Kenneth; Ventura, Joseph; Nuechterlein, Keith H; Cannon, Tyrone D

2015-03-01

Patients with and at risk for psychosis may have difficulty using associative strategies to facilitate episodic memory encoding and recall. In parallel studies, patients with first-episode schizophrenia ( n = 27) and high psychosis risk ( n = 28) compared with control participants ( n = 22 and n = 20, respectively) underwent functional MRI during a remember-know memory task. Psychophysiological interaction analyses, using medial temporal lobe (MTL) structures as regions of interest, were conducted to measure functional connectivity patterns supporting successful episodic memory. During encoding, patients with first-episode schizophrenia demonstrated reduced functional coupling between MTL regions and regions involved in stimulus representations, stimulus selection, and cognitive control. Relative to control participants and patients with high psychosis risk who did not convert to psychosis, patients with high psychosis risk who later converted to psychosis also demonstrated reduced connectivity between MTL regions and auditory-verbal and visual-association regions. These results suggest that episodic memory deficits in schizophrenia are related to inefficient recruitment of cortical connections involved in associative memory formation; such deficits precede the onset of psychosis among those individuals at high clinical risk.

Coastal landscape evolution on the western margin of the Bahía Blanca Estuary (Argentina) mirrors a non-uniform sea-level fall after the mid-Holocene highstand

NASA Astrophysics Data System (ADS)

Pratolongo, Paula; Piovan, María Julia; Cuadrado, Diana G.; Gómez, Eduardo A.

2017-08-01

Sedimentary descriptions and radiocarbon ages from two cores obtained from coastal plains along the western margin of the Bahía Blanca Estuary (Argentina) were integrated with previous information on landscape patterns and plant associations to infer landscape evolution during the mid-to-late Holocene. The study area comprises at least two marine terraces of different elevations. The old marine plain (OMP), at an average elevation of 5 m above mean tidal level (MTL), is a nearly continuous flat surface. The Recent marine plain (RMP), 2 to 3 m above MTL, is a mosaic of topographic highs and elongated depressions that may correspond to former tidal channels. Mollusks at the base of the OMP core (site elevation 5.09 m above MTL), with ages between 5,660 ± 30 and 5,470 ± 30 years BP, indicate a subtidal setting near the inland limits of the marine ingression. The sandy bottom of the core is interpreted as the last stage of the transgressive phase, followed by a tight sequence of dark laminated muds topped by a thick layer of massive gray muds. The RMP core (site elevation 1.80 m above MTL) has a similar sedimentary sequence, but unconformities appear at lower elevations and the massive mud deposits are less developed. The thickness of the grayish mud layer is a major difference between the OMP and RMP cores, but deeper layers have similar ages, suggesting a common origin at the end of the transgressive phase. The overlying massive muds would correspond to rapid sedimentation during a high sea-level stillstand or slow regression. It is proposed that, after a rapid sea-level drop to about 3 m above MTL, a flat and continuous surface corresponding to the OMP emerged, and more recent coastal dynamics shaped the dissected landscape of the RMP. For the Bahía Blanca Estuary, smooth regressive trends have been proposed after the mid-Holocene highstand, but also stepped curves. A stillstand or slowly dropping sea level was described around 3,850 ± 100 years BP, as well as negative relative sea-level oscillations. In this study, the differentiation between the OMP and the RMP supports the occurrence of a stepped regressive trend that, at least locally, presented two different stages.

Ecological stages of the Venice Lagoon analysed using landing time series data

NASA Astrophysics Data System (ADS)

Libralato, Simone; Pranovi, Fabio; Raicevich, Saša; Da Ponte, Filippo; Giovanardi, Otello; Pastres, Roberto; Torricelli, Patrizia; Mainardi, Danilo

2004-11-01

The time series of landings in the Venice Lagoon from 1945 to 2001 were analysed with the aim of explaining the ecosystem changes occurred. The comparative analysis of the total landings and mean Trophic Level (mTL) time series allowed to identify four different stages in the lagoon ecosystem. The first period, from 1945 to 1973, was characterised by increasing trends in the landings and their mTL. The second one, from 1974 to 1989, showed a decrease in the landings but still an increase in the mTL. The third period, from 1990 to 1998, had again a positive trend in the landings, but the mTL showed a sharp decline. After 1998, a slight decreasing trend in both mTL and landings was observed: the analyses of the artisanal fishery landings only date back to 1995 this effect. The presence of four distinct periods was also confirmed by the analysis of the trends of other indices estimated using landings data: the Fishing in Balance index (FiB), the Trophic Efficiency (TE) and the Pelagic on Demersal landings ratio (P/D). In the first period, the increasing fishing pressure, along with no evidence of ecosystem crisis, suggested that an increased nutrient discharge was supporting it; analogously, the bottom-up effects had driven the dynamics of the ecosystem also in the second period, when the decrease in nutrient loads caused a shift of the primary producers from planktonic to macrobenthic. The spreading of the Manila clam, a non-native species, and the development of its massive mechanical exploitation have been the main forces driving the ecosystem during the third period, for which, however, no signs of crises were detected. The fourth period showed evidence of the "fishing down the food web" effect. Possible causes of such an effect were investigated and allowed us to conclude that not overfishing, but the effects of mechanical harvesting of the Manila clam had caused relevant impacts on habitat and benthic communities, concluding that the present level of exploitation of the stock of Manila clam is not sustainable in the long term. Our findings were also compared with the general evolution of enclosed seas, subjected to high nutrient loads, fishing pressure and invasion by non-native species.

The Active Fault Parameters for Time-Dependent Earthquake Hazard Assessment in Taiwan

NASA Astrophysics Data System (ADS)

Lee, Y.; Cheng, C.; Lin, P.; Shao, K.; Wu, Y.; Shih, C.

2011-12-01

Taiwan is located at the boundary between the Philippine Sea Plate and the Eurasian Plate, with a convergence rate of ~ 80 mm/yr in a ~N118E direction. The plate motion is so active that earthquake is very frequent. In the Taiwan area, disaster-inducing earthquakes often result from active faults. For this reason, it's an important subject to understand the activity and hazard of active faults. The active faults in Taiwan are mainly located in the Western Foothills and the Eastern longitudinal valley. Active fault distribution map published by the Central Geological Survey (CGS) in 2010 shows that there are 31 active faults in the island of Taiwan and some of which are related to earthquake. Many researchers have investigated these active faults and continuously update new data and results, but few people have integrated them for time-dependent earthquake hazard assessment. In this study, we want to gather previous researches and field work results and then integrate these data as an active fault parameters table for time-dependent earthquake hazard assessment. We are going to gather the seismic profiles or earthquake relocation of a fault and then combine the fault trace on land to establish the 3D fault geometry model in GIS system. We collect the researches of fault source scaling in Taiwan and estimate the maximum magnitude from fault length or fault area. We use the characteristic earthquake model to evaluate the active fault earthquake recurrence interval. In the other parameters, we will collect previous studies or historical references and complete our parameter table of active faults in Taiwan. The WG08 have done the time-dependent earthquake hazard assessment of active faults in California. They established the fault models, deformation models, earthquake rate models, and probability models and then compute the probability of faults in California. Following these steps, we have the preliminary evaluated probability of earthquake-related hazards in certain faults in Taiwan. By accomplishing active fault parameters table in Taiwan, we would apply it in time-dependent earthquake hazard assessment. The result can also give engineers a reference for design. Furthermore, it can be applied in the seismic hazard map to mitigate disasters.

Long-term ecosystem change in the western North Pacific inferred from commercial fisheries and top predator diet

NASA Astrophysics Data System (ADS)

Yonezaki, Shiroh; Kiyota, Masashi; Okamura, Hiroshi

2015-03-01

Assessment of the current status of marine ecosystems is necessary for the sustainable utilization of ecosystem services through fisheries and other human activities under changing environmental conditions. Understanding of historical changes in marine ecosystems can help us to assess their current status. In this study, we analyzed Japanese commercial fishery catch data and scientific survey data of the diet of northern fur seal (Callorhinus ursinus, NFS) to investigate potential long-term ecosystem changes in the western North Pacific Ocean off northeastern Japan over the past 60 years. Total commercial catches experienced peaks around 1960 and during the 1980s, decreasing to low levels around 1970 and after 1990. Catches were substantively impacted by the Tohoku earthquake and tsunami in 2011. Species composition of the commercial catch changed over time, resulting in changes in the mean trophic level (MTL) of the catches. Trends in observed commercial catches were affected by many factors, including species population fluctuations potentially related to large-scale environmental shifts, migration and distribution patterns of species related to local oceanography, changes in fishing technology, and the introduction of fishery management frameworks. The composition of NFS diet also changed over time: although overall changes were small, MTL derived from NFS stomach contents declined from the early 1970s to the late 1980s. This fall in the MTL of the diet of NFS is suggestive of a shift in pelagic fish fauna from a "mackerel-dominant regime" to a "sardine-dominant regime". Inconsistencies between changes in species composition and MTLs of the commercial catch and NFS diet resulted from differences in commercial fishing targeting and NFS foraging behavior strategies. Although commercial catch is a valuable source of information for investigating historical changes in fisheries, biological resources, and ecosystems, catch data should be interpreted carefully and other relevant information available should also be considered.

Preventive effect of resistant starch on activated carbon-induced constipation in mice

PubMed Central

QIAN, YU; ZHAO, XIN; KAN, JIANQUAN

2013-01-01

The aim of this study was to investigate the effects of resistant starch (RS) on activated carbon-induced constipation in ICR mice. ICR mice were fed on diet containing 15% RS of type RS2, RS3 or RS4 for 9 days. Gastrointestinal transit, defecation time and intestinal tissue histopathological sections, as well as motilin (MTL), gastrin (Gas), endothelin (ET), somatostatin (SS), acetylcholinesterase (AChE), substance P (SP) and vasoactive intestinal peptide (VIP) levels in serum were used to evaluate the preventive effects of RS on constipation. Bisacodyl, a laxative drug, was used as a positive control. The time to the first black stool defecation for normal, control, bisacodyl-treated (100 mg/kg, oral administration) and RS2-, RS3- and RS4-treated mice was 78, 208, 109, 181, 144 and 173 min, respectively. Following the consumption of RS2, RS3 and RS4 or the oral administration of bisacodyl (100 mg/kg), the gastrointestinal transit was reduced to 37.7, 52.1, 39.3 and 87.3%, respectively, of the transit in normal mice, respectively. Histopathological sections of intestinal tissue also underscored the protective effect of RS3. The serum levels of MTL, Gas, ET, AChE, SP and VIP were significantly increased and the serum levels of SS were reduced in the mice treated with RS compared with those in the untreated control mice (P<0.05). These results demonstrate that RS has preventive effects on mouse constipation and RS3 demonstrated the best functional activity. PMID:23935751

Laterality effects in functional connectivity of the angular gyrus during rest and episodic retrieval.

PubMed

Bellana, Buddhika; Liu, Zhongxu; Anderson, John A E; Moscovitch, Morris; Grady, Cheryl L

2016-01-08

The angular gyrus (AG) is consistently reported in neuroimaging studies of episodic memory retrieval and is a fundamental node within the default mode network (DMN). Its specific contribution to episodic memory is debated, with some suggesting it is important for the subjective experience of episodic recollection, rather than retrieval of objective episodic details. Across studies of episodic retrieval, the left AG is recruited more reliably than the right. We explored functional connectivity of the right and left AG with the DMN during rest and retrieval to assess whether connectivity could provide insight into the nature of this laterality effect. Using data from the publically available 1000 Functional Connectome Project, 8min of resting fMRI data from 180 healthy young adults were analysed. Whole-brain functional connectivity at rest was measured using a seed-based Partial Least Squares (seed-PLS) approach (McIntosh and Lobaugh, 2004) with bilateral AG seeds. A subsequent analysis used 6-min of rest and 6-min of unconstrained, silent retrieval of autobiographical events from a new sample of 20 younger adults. Analysis of this dataset took a more targeted approach to functional connectivity analysis, consisting of univariate pairwise correlations restricted to nodes of the DMN. The seed-PLS analysis resulted in two Latent Variables that together explained ~86% of the shared cross-block covariance. The first LV revealed a common network consistent with the DMN and engaging the AG bilaterally, whereas the second LV revealed a less robust, yet significant, laterality effect in connectivity - the left AG was more strongly connected to the DMN. Univariate analyses of the second sample again revealed better connectivity between the left AG and the DMN at rest. However, during retrieval the left AG was more strongly connected than the right to non-medial temporal (MTL) nodes of the DMN, and MTL nodes were more strongly connected to the right AG. The multivariate analysis of resting connectivity revealed that the left and right AG show similar connectivity with the DMN. Only after accounting for this commonality were we able to detect a left laterality effect in DMN connectivity. Further probing with univariate connectivity analyses during retrieval demonstrates that the left preference we observe is restricted to the non-MTL regions of the DMN, whereas the right AG shows significantly better connectivity with the MTL. These data suggest bilateral involvement of the AG during retrieval, despite the focus on the left AG in the literature. Furthermore, the results suggest that the contribution of the left AG to retrieval may be separable from that of the MTL, consistent with a role for the left AG in the subjective aspects of recollection in memory, whereas the MTL and the right AG may contribute to objective recollection of specific memory details. Copyright © 2015 Elsevier Ltd. All rights reserved.

fMRI differences in encoding and retrieval of pictures due to encoding strategy in the elderly.

PubMed

Mandzia, Jennifer L; Black, Sandra E; McAndrews, Mary Pat; Grady, Cheryl; Graham, Simon

2004-01-01

Functional MRI (fMRI) was used to examine the neural correlates of depth of processing during encoding and retrieval of photographs in older normal volunteers (n = 12). Separate scans were run during deep (natural vs. man-made decision) and shallow (color vs. black-and-white decision) encoding and during old/new recognition of pictures initially presented in one of the two encoding conditions. A baseline condition consisting of a scrambled, color photograph was used as a contrast in each scan. Recognition accuracy was greater for the pictures on which semantic decisions were made at encoding, consistent with the expected levels of processing effect. A mixed-effects model was used to compare fMRI differences between conditions (deep-baseline vs. shallow-baseline) in both encoding and retrieval. For encoding, this contrast revealed greater activation associated with deep encoding in several areas, including the left parahippocampal gyrus (PHG), left middle temporal gyrus, and left anterior thalamus. Increased left hippocampal, right dorsolateral, and inferior frontal activations were found for recognition of items that had been presented in the deep relative to the shallow encoding condition. We speculate that the modulation of activity in these regions by the depth of processing manipulation shows that these regions support effective encoding and successful retrieval. A direct comparison between encoding and retrieval revealed greater activation during retrieval in the medial temporal (right hippocampus and bilateral PHG), anterior cingulate, and bilateral prefrontal (inferior and dorsolateral). Most notably, greater right posterior PHG was found during encoding compared to recognition. Focusing on the medial temporal lobe (MTL) region, our results suggest a greater involvement of both anterior MTL and prefrontal regions in retrieval compared to encoding. Copyright 2003 Wiley-Liss, Inc.

Geomorphic indices indicated differential active tectonics of the Longmen Shan

NASA Astrophysics Data System (ADS)

Gao, M.; Xu, X.; Tan, X.

2012-12-01

The Longmen Shan thrust belt is located at the eastern margin of the Tibetan Plateau. It is a region of rapid active tectonics with high erosion rates and dense vegetation. The structure of the Longmen Shan region is dominated by northeast-trending thrusts and overturned folds that verge to the east and southeast (Burchfiel et al. 1995, Chen and Wilson 1996). The Longmen Shan thrust belt consists of three major faults from west to east: back-range fault, central fault, and frontal-range fault. The Mw 7.9 Wenchuan earthquake ruptured two large thrust faults along the Longmen Shan thrust belt (Xiwei et al., 2009). In this paper, we focus on investigating the spatial variance of tectonic activeness from the back-range fault to the frontal-range fault, particular emphasis on the differential recent tectonic activeness reflected by the hypsometry and the asymmetric factor of the drainage. Results from asymmetric factor indicate the back-rannge thrust fault on the south of the Maoxian caused drainage basins tilted on the hanging wall. For the north of the Maoxian, the strike-slip fault controlled the shapes of the drainage basins. Constantly river capture caused the expansion of the drainage basins which traversed by the fault. The drainages on the central fault and the frontal-range fault are also controlled by the fault slip. The drainage asymmetric factor suggested the central and southern segments of the Longmen Shan are more active than the northern segment, which is coherence with results of Huiping et al. (2010). The results from hypsometry show the back-range fault is the most active fault among the three major faults. Central fault is less active than the back-range fault but more active than the frontal-range fault. Beichuan is identified as the most active area along the central fault. Our geomorphic indices reflect an overall eastward decreasing of tectonic activeness of the Longmen Shan thrust belt.

Recent tectonic stress field, active faults and geothermal fields (hot-water type) in China

NASA Astrophysics Data System (ADS)

Wan, Tianfeng

1984-10-01

It is quite probable that geothermal fields of the hot-water type in China do not develop in the absence of recently active faults. Such active faults are all controlled by tectonic stress fields. Using the data of earthquake fault-plane solutions, active faults, and surface thermal manifestations, a map showing the recent tectonic stress field, and the location of active faults and geothermal fields in China is presented. Data collected from 89 investigated prospects with geothermal manifestations indicate that the locations of geothermal fields are controlled by active faults and the recent tectonic stress field. About 68% of the prospects are controlled by tensional or tensional-shear faults. The angle between these faults and the direction of maximum compressive stress is less than 45°, and both tend to be parallel. About 15% of the prospects are controlled by conjugate faults. Another 14% are controlled by compressive-shear faults where the angle between these faults and the direction maximum compressive stress is greater than 45°.

MTL distributed magnet measurement system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nogiec, J.M.; Craker, P.A.; Garbarini, J.P.

1993-04-01

The Magnet Test Laboratory (MTL) at the Superconducting Super collider Laboratory will be required to precisely and reliably measure properties of magnets in a production environment. The extensive testing of the superconducting magnets comprises several types of measurements whose main purpose is to evaluate some basic parameters characterizing magnetic, mechanic and cryogenic properties of magnets. The measurement process will produce a significant amount of data which will be subjected to complex analysis. Such massive measurements require a careful design of both the hardware and software of computer systems, having in mind a reliable, maximally automated system. In order to fulfillmore » this requirement a dedicated Distributed Magnet Measurement System (DMMS) is being developed.« less

High-throughput, fully-automated volumetry for prediction of MMSE and CDR decline in mild cognitive impairment

PubMed Central

Kovacevic, Sanja; Rafii, Michael S.; Brewer, James B.

2008-01-01

Medial temporal lobe (MTL) atrophy is associated with increased risk for conversion to Alzheimer's disease (AD), but manual tracing techniques and even semi-automated techniques for volumetric assessment are not practical in the clinical setting. In addition, most studies that examined MTL atrophy in AD have focused only on the hippocampus. It is unknown the extent to which volumes of amygdala and temporal horn of the lateral ventricle predict subsequent clinical decline. This study examined whether measures of hippocampus, amygdala, and temporal horn volume predict clinical decline over the following 6-month period in patients with mild cognitive impairment (MCI). Fully-automated volume measurements were performed in 269 MCI patients. Baseline volumes of the hippocampus, amygdala, and temporal horn were evaluated as predictors of change in Mini-mental State Exam (MMSE) and Clinical Dementia Rating Sum of Boxes (CDR SB) over a 6-month interval. Fully-automated measurements of baseline hippocampus and amygdala volumes correlated with baseline delayed recall scores. Patients with smaller baseline volumes of the hippocampus and amygdala or larger baseline volumes of the temporal horn had more rapid subsequent clinical decline on MMSE and CDR SB. Fully-automated and rapid measurement of segmental MTL volumes may help clinicians predict clinical decline in MCI patients. PMID:19474571

Relationship between the Brazilian version of the Montreal-Toulouse language assessment battery and education, age and reading and writing characteristics. A cross-sectional study.

PubMed

Pagliarin, Karina Carlesso; Gindri, Gigiane; Ortiz, Karin Zazo; Parente, Maria Alice Mattos Pimenta; Joanette, Yves; Nespoulous, Jean-Luc; Fonseca, Rochele Paz

2015-01-01

There is growing concern about understanding how sociodemographic variables may interfere with cognitive functioning, especially with regard to language. This study aimed to investigate the relationship between performance in the Brazilian version of the Montreal-Toulouse language assessment battery (MTL-BR) and education, age and frequency of reading and writing habits (FRWH). Cross-sectional study conducted in university and work environments in Rio Grande do Sul, Brazil. The MTL-BR was administered to a group of 233 healthy adults, aged 19 to 75 years (mean = 45.04, standard deviation, SD = 15.47), with at least five years of formal education (mean = 11.47, SD = 4.77). A stepwise multiple linear regression model showed that, for most tasks, the number of years of education, age and FRWH were better predictors of performance when analyzed together rather than separately. In separate analysis, education was the best predictor of performance in language tasks, especially those involving reading and writing abilities. The results suggested that the number of years of education, age and FRWH seem to influence performance in the MTL-BR, especially education. These data are important for making diagnoses of greater precision among patients suffering from brain injuries, with the aim of avoiding false positives.

Memory for relations in the short term and the long term after medial temporal lobe damage.

PubMed

Squire, Larry R

2017-05-01

A central idea about the organization of declarative memory and the function of the hippocampus is that the hippocampus provides for the coding of relationships between items. A question arises whether this idea refers to the process of forming long-term memory or whether, as some studies have suggested, memory for relations might depend on the hippocampus even at short retention intervals and even when the task falls within the province of short-term (working) memory. The latter formulation appears to place the operation of relational memory into conflict with the idea that working memory is independent of medial temporal lobe (MTL) structures. In this report, the concepts of relational memory and working memory are discussed in the light of a simple demonstration experiment. Patients with MTL lesions successfully learned and recalled two word pairs when tested directly after learning but failed altogether when tested after a delay. The results do not contradict the idea that the hippocampus has a fundamental role in relational memory. However, there is a need for further elaboration and specification of the idea in order to explain why patients with MTL lesions can establish relational memory in the short term but not in long-term memory. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

Dominance of Objects over Context in a Mediotemporal Lobe Model of Schizophrenia

PubMed Central

Talamini, Lucia M.; Meeter, Martijn

2009-01-01

Background A large body of evidence suggests impaired context processing in schizophrenia. Here we propose that this impairment arises from defective integration of mediotemporal ‘what’ and ‘where’ routes, carrying object and spatial information to the hippocampus. Methodology and Findings We have previously shown, in a mediotemporal lobe (MTL) model, that the abnormal connectivity between MTL regions observed in schizophrenia can explain the episodic memory deficits associated with the disorder. Here we show that the same neuropathology leads to several context processing deficits observed in patients with schizophrenia: 1) failure to choose subordinate stimuli over dominant ones when the former fit the context, 2) decreased contextual constraints in memory retrieval, as reflected in increased false alarm rates and 3) impaired retrieval of contextual information in source monitoring. Model analyses show that these deficits occur because the ‘schizophrenic MTL’ forms fragmented episodic representations, in which objects are overrepresented at the expense of spatial contextual information. Conclusions and Significance These findings highlight the importance of MTL neuropathology in schizophrenia, demonstrating that it may underlie a broad spectrum of deficits, including context processing and memory impairments. It is argued that these processing deficits may contribute to central schizophrenia symptoms such as contextually inappropriate behavior, associative abnormalities, conversational drift, concreteness and delusions. PMID:19652706

Genome-Based Genetic Tool Development for Bacillus methanolicus: Theta- and Rolling Circle-Replicating Plasmids for Inducible Gene Expression and Application to Methanol-Based Cadaverine Production.

PubMed

Irla, Marta; Heggeset, Tonje M B; Nærdal, Ingemar; Paul, Lidia; Haugen, Tone; Le, Simone B; Brautaset, Trygve; Wendisch, Volker F

2016-01-01

Bacillus methanolicus is a thermophilic methylotroph able to overproduce amino acids from methanol, a substrate not used for human or animal nutrition. Based on our previous RNA-seq analysis a mannitol inducible promoter and a putative mannitol activator gene mtlR were identified. The mannitol inducible promoter was applied for controlled gene expression using fluorescent reporter proteins and a flow cytometry analysis, and improved by changing the -35 promoter region and by co-expression of the mtlR regulator gene. For independent complementary gene expression control, the heterologous xylose-inducible system from B. megaterium was employed and a two-plasmid gene expression system was developed. Four different replicons for expression vectors were compared with respect to their copy number and stability. As an application example, methanol-based production of cadaverine was shown to be improved from 11.3 to 17.5 g/L when a heterologous lysine decarboxylase gene cadA was expressed from a theta-replicating rather than a rolling-circle replicating vector. The current work on inducible promoter systems and compatible theta- or rolling circle-replicating vectors is an important extension of the poorly developed B. methanolicus genetic toolbox, valuable for genetic engineering and further exploration of this bacterium.

Genome-Based Genetic Tool Development for Bacillus methanolicus: Theta- and Rolling Circle-Replicating Plasmids for Inducible Gene Expression and Application to Methanol-Based Cadaverine Production

PubMed Central

Irla, Marta; Heggeset, Tonje M. B.; Nærdal, Ingemar; Paul, Lidia; Haugen, Tone; Le, Simone B.; Brautaset, Trygve; Wendisch, Volker F.

2016-01-01

Bacillus methanolicus is a thermophilic methylotroph able to overproduce amino acids from methanol, a substrate not used for human or animal nutrition. Based on our previous RNA-seq analysis a mannitol inducible promoter and a putative mannitol activator gene mtlR were identified. The mannitol inducible promoter was applied for controlled gene expression using fluorescent reporter proteins and a flow cytometry analysis, and improved by changing the -35 promoter region and by co-expression of the mtlR regulator gene. For independent complementary gene expression control, the heterologous xylose-inducible system from B. megaterium was employed and a two-plasmid gene expression system was developed. Four different replicons for expression vectors were compared with respect to their copy number and stability. As an application example, methanol-based production of cadaverine was shown to be improved from 11.3 to 17.5 g/L when a heterologous lysine decarboxylase gene cadA was expressed from a theta-replicating rather than a rolling-circle replicating vector. The current work on inducible promoter systems and compatible theta- or rolling circle-replicating vectors is an important extension of the poorly developed B. methanolicus genetic toolbox, valuable for genetic engineering and further exploration of this bacterium. PMID:27713731

Laser ablation for mesial temporal lobe epilepsy: Surgical and cognitive outcomes with and without mesial temporal sclerosis.

PubMed

Donos, Cristian; Breier, Joshua; Friedman, Elliott; Rollo, Patrick; Johnson, Jessica; Moss, Lauren; Thompson, Stephen; Thomas, Melissa; Hope, Omotola; Slater, Jeremy; Tandon, Nitin

2018-06-12

Laser interstitial thermal therapy (LITT) is a minimally invasive surgical technique for focal epilepsy. A major appeal of LITT is that it may result in fewer cognitive deficits, especially when targeting dominant hemisphere mesial temporal lobe (MTL) epilepsy. To evaluate this, as well as to determine seizure outcomes following LITT, we evaluated the relationships between ablation volumes and surgical or cognitive outcomes in 43 consecutive patients undergoing LITT for MTL epilepsy. All patients underwent unilateral LITT targeting mesial temporal structures. FreeSurfer software was used to derive cortical and subcortical segmentation of the brain (especially subregions of the MTL) using preoperative magnetic resonance imaging (MRI). Ablation volumes were outlined using a postablation T1-contrasted MRI. The percentages of the amygdala, hippocampus, and entorhinal cortex ablated were quantified objectively. The volumetric measures were regressed against changes in neuropsychological performance before and after surgery, RESULTS: A median of 73.7% of amygdala, 70.9% of hippocampus, and 28.3% of entorhinal cortex was ablated. Engel class I surgical outcome was obtained in 79.5% and 67.4% of the 43 patients at 6 and 20.3 months of follow-up, respectively. No significant differences in surgical outcomes were found across patient subgroups (hemispheric dominance, hippocampal sclerosis, or need for intracranial evaluation). Furthermore, no significant differences in volumes ablated were found between patients with Engel class IA vs Engel class II-IV outcomes. In patients undergoing LITT in the dominant hemisphere, a decline in verbal and narrative memory, but not in naming function was noted. Seizure-free outcomes following LITT may be comparable in carefully selected patients with and without MTS, and these outcomes are comparable with outcomes following microsurgical resection. Failures may result from non-mesial components of the epileptogenic network that are not affected by LITT. Cognitive declines following MTL-LITT are modest, and principally affect memory processes. Wiley Periodicals, Inc. © 2018 International League Against Epilepsy.

Visual short-term memory for high resolution associations is impaired in patients with medial temporal lobe damage.

PubMed

Koen, Joshua D; Borders, Alyssa A; Petzold, Michael T; Yonelinas, Andrew P

2017-02-01

The medial temporal lobe (MTL) plays a critical role in episodic long-term memory, but whether the MTL is necessary for visual short-term memory is controversial. Some studies have indicated that MTL damage disrupts visual short-term memory performance whereas other studies have failed to find such evidence. To account for these mixed results, it has been proposed that the hippocampus is critical in supporting short-term memory for high resolution complex bindings, while the cortex is sufficient to support simple, low resolution bindings. This hypothesis was tested in the current study by assessing visual short-term memory in patients with damage to the MTL and controls for high resolution and low resolution object-location and object-color associations. In the location tests, participants encoded sets of two or four objects in different locations on the screen. After each set, participants performed a two-alternative forced-choice task in which they were required to discriminate the object in the target location from the object in a high or low resolution lure location (i.e., the object locations were very close or far away from the target location, respectively). Similarly, in the color tests, participants were presented with sets of two or four objects in a different color and, after each set, were required to discriminate the object in the target color from the object in a high or low resolution lure color (i.e., the lure color was very similar or very different, respectively, to the studied color). The patients were significantly impaired in visual short-term memory, but importantly, they were more impaired for high resolution object-location and object-color bindings. The results are consistent with the proposal that the hippocampus plays a critical role in forming and maintaining complex, high resolution bindings. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

Brest sea level record: a time series construction back to the early eighteenth century

NASA Astrophysics Data System (ADS)

Wöppelmann, Guy; Pouvreau, Nicolas; Simon, Bernard

2006-12-01

The completeness and the accuracy of the Brest sea level time series dating from 1807 make it suitable for long-term sea level trend studies. New data sets were recently discovered in the form of handwritten tabulations, including several decades of the eighteenth century. Sea level observations have been made in Brest since 1679. This paper presents the historical data sets which have been assembled so far. These data sets span approximately 300 years and together constitute the longest, near-continuous set of sea level information in France. However, an important question arises: Can we relate the past and the present-day records? We partially provide an answer to this question by analysing the documents of several historical libraries with the tidal data using a ‘data archaeology’ approach advocated by Woodworth ( Geophys Res Lett 26:1589 1592, 1999b). A second question arises concerning the accuracy of such records. Careful editing was undertaken by examining the residuals between tidal predictions and observations. It proved useful to remove the worst effects of timing errors, in particular the sundial correction to be applied prior to August 1, 1714. A refined correction based on sundial literature [Savoie, La gnomique, Editions Les Belles Lettres, Paris, 2001] is proposed, which eliminates the systematic offsets seen in the discrepancies in timing of the sea level measurements. The tidal analysis has also shown that shallow-water tidal harmonics at Brest causes a systematic difference of 0.023 m between mean sea level (MSL) and mean tide level (MTL). Thus, MTL should not be mixed with the time series of MSL because of this systematic offset. The study of the trends in MTL and MSL however indicates that MTL can be used as a proxy for MSL. Three linear trend periods are distinguished in the Brest MTL time series over the period 1807 2004. Our results support the recent findings of Holgate and Woodworth ( Geophys Res Lett) of an enhanced coastal sea level rise during the last decade compared to the global estimations of about 1.8 mm/year over longer periods (Douglas, J Geophys Res 96:6981 6992, 1991). The onset of the relatively large global sea level trends observed in the twentieth century is an important question in the science of climate change. Our findings point out to an ‘inflexion point’ at around 1890, which is remarkably close to that in 1880 found in the Liverpool record by Woodworth ( Geophys Res Lett 26:1589 1592, 1999b).

Therapeutic Effect of Activated Carbon-Induced Constipation Mice with Lactobacillus fermentum Suo on Treatment

PubMed Central

Suo, Huayi; Zhao, Xin; Qian, Yu; Li, Guijie; Liu, Zhenhu; Xie, Jie; Li, Jian

2014-01-01

The aim of this study was to investigate the effects of Lactobacillus fermentum Suo (LF-Suo) on activated carbon-induced constipation in ICR (Institute of Cancer Research) mice. ICR mice were orally administered with lactic acid bacteria for 9 days. Body weight, diet intake, drinking amount, defecation status, gastrointestinal transit and defecation time, and the serum levels of MTL (motilin), Gas (gastrin), ET (endothelin), SS (somatostatin), AChE (acetylcholinesterase), SP (substance P), VIP (vasoactive intestinal peptide) were used to evaluate the preventive effects of LF-Suo on constipation. Bisacodyl, a laxative drug, was used as a positive control. The normal, control, 100 mg/kg bisacodyl treatment, LB (Lactobacillus bulgaricus)-, LF-Suo (L)- and LF-Suo (H)-treated mice showed the time to the first black stool defecation at 90, 218, 117, 180, 155 and 137 min, respectively. By the oral administration of LB-, LF-Suo (L), LF-Suo (H) or bisacodyl (100 mg/kg), the gastrointestinal transit was reduced to 55.2%, 72.3%, 85.5% and 94.6%, respectively, of the transit in normal mice, respectively. In contrast to the control mice, the serum levels of MTL, Gas, ET, AChE, SP and VIP were significantly increased and the serum levels of SS were reduced in the mice treated with LF-Suo (p < 0.05). By the RT-PCR (reverse transcription–polymerase chain reaction) and western blot assays, LF-Suo increased the c-Kit, SCF (stem cell factor), GDNF (glial cell line-derived neurotrophic factor) and decreased TRPV1 (transient receptor potential vanilloid 1), NOS (nitric oxide synthase) expressions of small intestine tissue in mice. These results demonstrate that lactic acid bacteria has preventive effects on mouse constipation and LF-Suo demonstrated the best functional activity. PMID:25464378

Examining Relay Ramp Evolution Through Paleo-shoreline Deformation Analysis, Warner Valley Fault, Oregon

NASA Astrophysics Data System (ADS)

Young, C. S.; Dawers, N. H.

2017-12-01

Fault growth is often accomplished by linking a series of en echelon faults through relay ramps. A relay ramp is the area between two overlapping fault segments that tilts and deforms as the faults accrue displacement. The structural evolution of breached normal fault relay ramps remains poorly understood because of the difficulty in defining how slip is partitioned between the most basinward fault (known as the outboard fault), the overlapping fault (inboard fault), and any ramp-breaching linking faults. Along the Warner Valley fault in south-central Oregon, two relay ramps displaying different fault linkage geometries are lined with a series of paleo-lacustrine shorelines that record a Pleistocene paleolake regression. The inner edges of these shorelines act as paleo-horizontal datums that have been deformed by fault activity, and are used to measure relative slip variations across the relay ramp bounding faults. By measuring the elevation changes using a 10m digital elevation model (DEM) of shoreline inner edges, we estimate the amount of slip partitioned between the inboard, outboard and ramp-breaching linking faults. In order to attribute shoreline deformation to fault activity we identify shoreline elevation anomalies, where deformation exceeds a ± 3.34 m window, which encompass our conservative estimates of natural variability in the shoreline geomorphology and the error associated with the data collection. Fault activity along the main length of the fault for each ramp-breaching style is concentrated near the intersection of the linking fault and the outboard portion of the main fault segment. However, fault activity along the outboard fault tip varies according to breaching style. At a footwall breach the entire outboard fault tip appears relatively inactive. At a mid-ramp breach the outboard fault tip remains relatively active because of the proximity of the linking fault to this fault tip.

Investigation of Aceh Segment and Seulimeum Fault by using seismological data; A preliminary result

NASA Astrophysics Data System (ADS)

Muksin, U.; Irwandi; Rusydy, I.; Muzli; Erbas, K.; Marwan; Asrillah; Muzakir; Ismail, N.

2018-04-01

The Seulimeum Fault has not generated large earthquake after last large earthquake with magnitude of M 7.3 occured in 1936. The Seulimeum Fault is accompanied by the Seulawah volcano that reported to be active in 1839, 1975 and 2010. The activity of the Seulimeum Fault could be related with the existence of the Seulawah volcano and the Seulawah volcano activity could also triggered by the Seulumeum Fault activity. The objective of the longterm research is to investigate the relation between the Seulimeum Fault and the Seulawah Volcano. The aim of this paper is to present the first result of the investigation of the Seulimeum Fault based on the seismicity and geomorphology. A seismic network consisting of 17 seismometers (Trilium Compact) and data logger (DSS Cube) were deployed in Aceh Besar. The seismic network was installed for 3 months to record earthquakes along the Seulimeum and the Aceh Faults. The Seulimeum Fault is considered to be active as several local earthquakes were recorded. The Seulimeum Fault is much more active in the region of the bifurcation of the The Aceh Segment and the Seulimeum Fault. The mechanisms of earthquakes along the Seulimeum Fault were mostly strike slip following similar to the Sumatran Fault characteristics.

A Survey of Memristive Threshold Logic Circuits.

PubMed

Maan, Akshay Kumar; Jayadevi, Deepthi Anirudhan; James, Alex Pappachen

2017-08-01

In this paper, we review different memristive threshold logic (MTL) circuits that are inspired from the synaptic action of the flow of neurotransmitters in the biological brain. The brainlike generalization ability and the area minimization of these threshold logic circuits aim toward crossing Moore's law boundaries at device, circuits, and systems levels. Fast switching memory, signal processing, control systems, programmable logic, image processing, reconfigurable computing, and pattern recognition are identified as some of the potential applications of MTL systems. The physical realization of nanoscale devices with memristive behavior from materials, such as TiO 2 , ferroelectrics, silicon, and polymers, has accelerated research effort in these application areas, inspiring the scientific community to pursue the design of high-speed, low-cost, low-power, and high-density neuromorphic architectures.

Multi-task learning with group information for human action recognition

NASA Astrophysics Data System (ADS)

Qian, Li; Wu, Song; Pu, Nan; Xu, Shulin; Xiao, Guoqiang

2018-04-01

Human action recognition is an important and challenging task in computer vision research, due to the variations in human motion performance, interpersonal differences and recording settings. In this paper, we propose a novel multi-task learning framework with group information (MTL-GI) for accurate and efficient human action recognition. Specifically, we firstly obtain group information through calculating the mutual information according to the latent relationship between Gaussian components and action categories, and clustering similar action categories into the same group by affinity propagation clustering. Additionally, in order to explore the relationships of related tasks, we incorporate group information into multi-task learning. Experimental results evaluated on two popular benchmarks (UCF50 and HMDB51 datasets) demonstrate the superiority of our proposed MTL-GI framework.

Active faults in Africa: a review

NASA Astrophysics Data System (ADS)

Skobelev, S. F.; Hanon, M.; Klerkx, J.; Govorova, N. N.; Lukina, N. V.; Kazmin, V. G.

2004-03-01

The active fault database and Map of active faults in Africa, in scale of 1:5,000,000, were compiled according to the ILP Project II-2 "World Map of Major Active Faults". The data were collected in the Royal Museum of Central Africa, Tervuren, Belgium, and in the Geological Institute, Moscow, where the final edition was carried out. Active faults of Africa form three groups. The first group is represented by thrusts and reverse faults associated with compressed folds in the northwest Africa. They belong to the western part of the Alpine-Central Asian collision belt. The faults disturb only the Earth's crust and some of them do not penetrate deeper than the sedimentary cover. The second group comprises the faults of the Great African rift system. The faults form the known Western and Eastern branches, which are rifts with abnormal mantle below. The deep-seated mantle "hot" anomaly probably relates to the eastern volcanic branch. In the north, it joins with the Aden-Red Sea rift zone. Active faults in Egypt, Libya and Tunis may represent a link between the East African rift system and Pantellerian rift zone in the Mediterranean. The third group included rare faults in the west of Equatorial Africa. The data were scarce, so that most of the faults of this group were identified solely by interpretation of space imageries and seismicity. Some longer faults of the group may continue the transverse faults of the Atlantic and thus can penetrate into the mantle. This seems evident for the Cameron fault line.

fMRI studies of successful emotional memory encoding: a quantitative meta-analysis

PubMed Central

Murty, Vishnu P.; Ritchey, Maureen; Adcock, R. Alison; LaBar, Kevin S.

2010-01-01

Over the past decade, fMRI techniques have been increasingly used to interrogate the neural correlates of successful emotional memory encoding. These investigations have typically aimed to either characterize the contributions of the amygdala and medial temporal lobe (MTL) memory system, replicating results in animals, or delineate the neural correlates of specific behavioral phenomena. It has remained difficult, however, to synthesize these findings into a systems neuroscience account of how networks across the whole brain support the enhancing effects of emotion on memory encoding. To this end, the present study employed a meta-analytic approach using activation likelihood estimates to assess the anatomical specificity and reliability of event-related fMRI activations related to successful memory encoding for emotional versus neutral information. The meta-analysis revealed consistent clusters within bilateral amygdala, anterior hippocampus, anterior and posterior parahippocampal gyrus, the ventral visual stream, left lateral prefrontal cortex and right ventral parietal cortex. The results within the amygdala and MTL support a wealth of findings from the animal literature linking these regions to arousal-mediated memory effects. The consistency of findings in cortical targets, including the visual, prefrontal, and parietal cortices, underscores the importance of generating hypotheses regarding their participation in emotional memory formation. In particular, we propose that the amygdala interacts with these structures to promote enhancements in perceptual processing, semantic elaboration, and attention, which serve to benefit subsequent memory for emotional material. These findings may motivate future research on emotional modulation of widespread neural systems and the implications of this modulation for cognition. PMID:20688087

Active Structures as Deduced from Geomorphic Features: A case in Hsinchu Area, northwestern Taiwan

NASA Astrophysics Data System (ADS)

Chen, Y.; Shyu, J.; Ota, Y.; Chen, W.; Hu, J.; Tsai, B.; Wang, Y.

2002-12-01

Hsinchu area is located in the northwestern Taiwan, the fold-and thrust belt created by arc-continent collision between Eurasian and Philippine. Since the collision event is still ongoing, the island is tectonically active and full of active faults. According to the historical records, some of the faults are seismically acting. In Hsinchuarea two active faults, the Hsinchu and Hsincheng, have been previously mapped. To evaluate the recent activities, we studied the related geomorphic features by using newly developed Digital Elevation Model (DEM), the aerial photos and field investigation. Geologically, both of the faults are coupled with a hanging wall anticline. The anticlines are recently active due to the deformation of the geomorphic surfaces. The Hsinchu fault system shows complicate corresponding scarps, distributed sub-parallel to the fault trace previously suggested by projection of subsurface geology. This is probably caused by its strike-slip component tearing the surrounding area along the main trace. The scarps associated with the Hsincheng fault system are rather simple and unique. It offsets a flight of terraces all the way down to recent flood plain, indicating its long lasting activity. One to two kilometers to east of main trace a back-thrust is found, showing coupled vertical surface offsets with the main fault. The striking discovery in this study is that the surface deformation is only distributed in the southern bank of Touchien river, also suddenly decreasing when crossing another tear fault system, which is originated from Hsincheng fault in the west and extending southeastward parallel to the Touchien river. The strike-slip fault system mentioned above not only bisects the Hsinchu fault, but also divides the Hsincheng fault into segments. The supporting evidence found in this study includes pressure ridges and depressions. As a whole, the study area is tectonically dominated by three active fault systems and two actively growing anticlines. The interactions between active structural systems formed the complicate geomorphic features presented in this paper.

Analysis of the expression of putative heat-stress related genes in relation to thermotolerance of cork oak.

PubMed

Correia, Barbara; Rodriguez, José Luis; Valledor, Luis; Almeida, Tânia; Santos, Conceição; Cañal, Maria Jesús; Pinto, Glória

2014-03-15

Cork oak (Quercus suber L.) is a research priority in the Mediterranean area and because of cork oaks' distribution these stands are experiencing daily stress. Based on projections of intensifying climate change and considering the key role of exploring the recovery abilities, cork oak seedlings were subjected to a cumulative temperature increase from 25°C to 55°C and subsequent recovery. CO2 assimilation rate, chlorophyll fluorescence, anthocyanins, proline and lipid peroxidation were used to evaluate plant performance, while the relative abundance of seven genes encoding for proteins of cork oak with a putative role in thermal/stress regulation (POX1, POX2, HSP10.4, HSP17a.22, CHS, MTL and RBC) was analyzed by qPCR (quantitative Polymerase Chain Reaction). A temperature change to 35°C showed abundance alterations in the tested genes; at 45°C, the molecular changes were associated with an antioxidant response, possibly modulated by anthocyanins. At 55°C, HSP17a.22, MTL and proline accumulation were evident. After recovery, physiological balance was restored, whereas POX1, HSP10.4 and MTL abundances were suggested to be involved in increased thermotolerance. The data presented here are expected to pinpoint some pathways changes occurring during such stress and further recovery in this particular Mediterranean species. Copyright © 2013 Elsevier GmbH. All rights reserved.

Hippocampal contributions to recollection in retrograde and anterograde amnesia.

PubMed

Gilboa, Asaf; Winocur, Gordon; Rosenbaum, R Shayna; Poreh, Amir; Gao, Fuqiang; Black, Sandra E; Westmacott, Robyn; Moscovitch, Morris

2006-01-01

Lesions restricted to the hippocampal formation and/or extended hippocampal system (hippocampal formation, fornix, mammillary bodies, and anterior thalamic nuclei) can disrupt conscious recollection in anterograde amnesia, while leaving familiarity-based memory relatively intact. Familiarity may be supported by extra-hippocampal medial temporal lobe (MTL) structures. Within-task dissociations in recognition memory best exemplify this distinction in anterograde amnesia. The authors report for the first time comparable dissociations within recognition memory in retrograde amnesia. An amnesic patient (A.D.) with bilateral fornix and septal nuclei lesions failed to recognize details pertaining to personal past events only when recollection was required, during recognition of episodic details. His intact recognition of generic and semantic details pertaining to the same events was ascribed to intact familiarity processes. Recollective processes in the controls were reflected by asymmetrical Receiver's Operating Characteristic curves, whereas the patient's Receiver's Operating Characteristic was symmetrical, suggesting that his inferior recognition performance on episodic details was reliant on familiarity processes. Anterograde and retrograde memories were equally affected, with no temporal gradient for retrograde memories. By comparison, another amnesic person (K.C.) with extensive MTL damage (involving extra-hippocampal MTL structures in addition to hippocampal and fornix lesions) had very poor recognition and no recollection of either episodic or generic/semantic details. These data suggest that the extended hippocampal system is required to support recollection for both anterograde and retrograde memories, regardless of their age.

Effects of economics and demographics on global fisheries sustainability.

PubMed

Ding, Qi; Wang, Yali; Chen, Xinjun; Chen, Yong

2017-08-01

A good understanding of social factors that lead to marine ecological change is important to developing sustainable global fisheries. We used balanced panel models and conducted cross-national time-series analyses (1970-2010) of 122 nations to examine how economic prosperity and population growth affected the sustainability of marine ecosystems. We used catches in economic exclusive zone (EEZ); mean trophic level of fishery landings (MTL); primary production required to sustain catches (expressed as percentage of local primary production [%PPR]); and an index of ecosystem overfishing (i.e., the loss in secondary production index [L index]) as indicators of ecological change in marine ecosystems. The EEZ catch, %PPR, and L index declined gradually after gross domestic product (GDP) per capita reached $15,000, $14,000, and $19,000, respectively, and MTL increased steadily once GDP per capita exceeded $20,000. These relationships suggest that economic growth and biodiversity conservation are compatible goals. However, increasing human populations would degrade marine ecosystems. Specifically, a doubling of human population caused an increase in the %PPR of 17.1% and in the L index of 0.0254 and a decline in the MTL of 0.176. A 1% increase in human population resulted in a 0.744% increase in EEZ catch. These results highlight the importance of considering social and economic factors in developing sustainable fisheries management policy. © 2016 Society for Conservation Biology.

Structure and chemical organization of the accessory olfactory bulb in the goat.

PubMed

Mogi, Kazutaka; Sakurai, Katsuyasu; Ichimaru, Toru; Ohkura, Satoshi; Mori, Yuji; Okamura, Hiroaki

2007-03-01

The structure and chemical composition of the accessory olfactory bulb (AOB) were examined in male and female goats. Sections were subjected to either Nissl staining, Klüver-Barrera staining, lectin histochemistry, or immunohistochemistry for nitric oxide synthase (NOS), neuropeptide Y (NPY), tyrosine hydroxylase (TH), dopamine beta-hydroxylase (DBH), and glutamic acid decarboxylase (GAD). The goat AOB was divided into four layers: the vomeronasal nerve layer (VNL), glomerular layer (GL), mitral/tufted (M/T) cell layer (MTL), and granule cell layer (GRL). Quantitative and morphometric analyses indicated that a single AOB contained 5,000-8,000 putative M/T cells with no sex differences, whereas the AOB was slightly larger in males. Of the 21 lectins examined, 7 specifically bound to the VNL and GL, and 1 bound not only to the VNL, but also to the MTL and GRL. In either of these cases, no heterogeneity of lectin staining was observed in the rostrocaudal direction. NOS-, TH-, DBH-, and GAD-immunoreactivity (ir) were observed in the MTL and GRL, whereas NPY-ir was present only in the GRL. In the GL, periglomerular cells with GAD-ir were found in abundance, and a subset of periglomerular cells containing TH-ir was also found. Double-labeling immunohistochemistry revealed that virtually all periglomerular cells containing TH-ir were colocalized with GAD-ir.

A human volunteer study to assess the impact of confectionery sweeteners on the gut microbiota composition.

PubMed

Beards, Emma; Tuohy, Kieran; Gibson, Glenn

2010-09-01

Sweeteners are being sourced to lower the energetic value of confectionery including chocolates. Some, especially non-digestible carbohydrates, may possess other benefits for human health upon their fermentation by the colonic microbiota. The present study assessed non-digestible carbohydrate sweeteners, selected for use in low-energy chocolates, for their ability to beneficially modulate faecal bacterial profiles in human volunteers. Forty volunteers consumed a test chocolate (low-energy or experimental chocolate) containing 22.8 g of maltitol (MTL), MTL and polydextrose (PDX), or MTL and resistant starch for fourteen consecutive days. The dose of the test chocolates was doubled every 2 weeks over a 6-week period. Numbers of faecal bifidobacteria significantly increased with all the three test treatments. Chocolate containing the PDX blend also significantly increased faecal lactobacilli (P = 0.00 001) after the 6 weeks. The PDX blend also showed significant increases in faecal propionate and butyrate (P = 0.002 and 0.006, respectively). All the test chocolates were well tolerated with no significant change in bowel habit or intestinal symptoms even at a daily dose of 45.6 g of non-digestible carbohydrate sweetener. This is of importance not only for giving manufacturers a sugar replacement that can reduce energetic content, but also for providing a well-tolerated means of delivering high levels of non-digestible carbohydrates into the colon, bringing about improvements in the biomarkers of gut health.

Identification of putative estrogen receptor-mediated endocrine disrupting chemicals using QSAR- and structure-based virtual screening approaches

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Liying; Sedykh, Alexander; Tripathi, Ashutosh

2013-10-01

Identification of endocrine disrupting chemicals is one of the important goals of environmental chemical hazard screening. We report on the development of validated in silico predictors of chemicals likely to cause estrogen receptor (ER)-mediated endocrine disruption to facilitate their prioritization for future screening. A database of relative binding affinity of a large number of ERα and/or ERβ ligands was assembled (546 for ERα and 137 for ERβ). Both single-task learning (STL) and multi-task learning (MTL) continuous quantitative structure–activity relationship (QSAR) models were developed for predicting ligand binding affinity to ERα or ERβ. High predictive accuracy was achieved for ERα bindingmore » affinity (MTL R{sup 2} = 0.71, STL R{sup 2} = 0.73). For ERβ binding affinity, MTL models were significantly more predictive (R{sup 2} = 0.53, p < 0.05) than STL models. In addition, docking studies were performed on a set of ER agonists/antagonists (67 agonists and 39 antagonists for ERα, 48 agonists and 32 antagonists for ERβ, supplemented by putative decoys/non-binders) using the following ER structures (in complexes with respective ligands) retrieved from the Protein Data Bank: ERα agonist (PDB ID: 1L2I), ERα antagonist (PDB ID: 3DT3), ERβ agonist (PDB ID: 2NV7), and ERβ antagonist (PDB ID: 1L2J). We found that all four ER conformations discriminated their corresponding ligands from presumed non-binders. Finally, both QSAR models and ER structures were employed in parallel to virtually screen several large libraries of environmental chemicals to derive a ligand- and structure-based prioritized list of putative estrogenic compounds to be used for in vitro and in vivo experimental validation. - Highlights: • This is the largest curated dataset inclusive of ERα and β (the latter is unique). • New methodology that for the first time affords acceptable ERβ models. • A combination of QSAR and docking enables prediction of affinity and function. • The results have potential applications to green chemistry. • Models are publicly available for virtual screening via a web portal.« less

NanTroSEIZE observatories: Installation of a long-term borehole monitoring systems offshore the Kii Peninsula, Japan

NASA Astrophysics Data System (ADS)

Kopf, A.; Saffer, D. M.; Davis, E. E.; Araki, E.; Kinoshita, M.; Lauer, R. M.; Wheat, C. G.; Kitada, K.; Kimura, T.; Toczko, S.; Eguchi, N. O.; Science Parties, E.

2010-12-01

The IODP Nankai Trough Seismogenic Zone Experiment (NanTroSEIZE) is a multi-expedition drilling program designed to investigate fault mechanics, fault slip behavior, and strain accumulation along subduction megathrusts, through coring, logging, and long-term monitoring experiments. One key objective is the development and installation of a borehole observatory network extending from locations above the outer, presumably aseismic accretionary wedge to the seismogenic and interseismically locked plate interface, to record seismicity and slip transients, monitor strain accumulation, document hydraulic transients associated with deformation events, and quantify in situ pore fluid pressure and temperature. As part of recent NanTroSEIZE operations, borehole instruments have been developed for deployment at two sites: (1) Site C0010, which penetrates a major out-of-sequence thrust fault termed the “megasplay” at ca. 400 mbsf, and (2) Site C0002 in the Kumano forearc basin at a location that overlies both the updip edge of the inferred interseismically locked portion of the plate interface, and clusters of very low frequency thrust and reverse earthquakes located within the accretionary prism and potentially on the megasplay fault. In 2009, Site C0010 was drilled and cased with screens to access the megasplay fault, and a simple pore pressure and temperature monitoring system (a ”smartplug”) was installed. The simple observatory unit includes pressure and temperature sensors and a data logging package mounted beneath a mechanically set retrievable casing packer, and includes two pressure sensors, one in hydraulic communication with the formation through the casing screens below the packer, and the other to the open borehole above the packer to record hydrostatic reference pressure and ocean loading signals. Temperatures are recorded within the instrument package using a platinum thermometer and by a self-contained miniature temperature logger (MTL). In fall 2010, the smartplug will be retrieved and replaced with an upgraded instrument package that also includes an autonomous osmotic geochemical sampling system and microbial colonization experiment. Fall 2010 operations will also drill and case Site C0002 to ca. 1000 m depth and install a newly developed multi-sensor permanent observatory system, which includes a volumetric strainmeter, a broadband seismometer, tiltmeter, thermister string, and multi-level pore-pressure sensors. The strain, seismometer, and tilt sensors will be cemented with the basal mudstones of the Kumano basin, and pore pressure will be monitored within both the underlying accretionary prism and within the lower basin sediments. The observatory will ultimately be connected to the seafloor fiber-optic cable network DONET. Here, we report on the retrieval of the smartplug, installation and configuration of the new multi-sensor permanent observatory, and preliminary data obtained from the smartplug deployment.

Mountain front migration and drainage captures related to fault segment linkage and growth: The Polopos transpressive fault zone (southeastern Betics, SE Spain)

NASA Astrophysics Data System (ADS)

Giaconia, Flavio; Booth-Rea, Guillermo; Martínez-Martínez, José Miguel; Azañón, José Miguel; Pérez-Romero, Joaquín; Villegas, Irene

2013-01-01

The Polopos E-W- to ESE-WNW-oriented dextral-reverse fault zone is formed by the North Alhamilla reverse fault and the North and South Gafarillos dextral faults. It is a conjugate fault system of the sinistral NNE-SSW Palomares fault zone, active from the late most Tortonian (≈7 Ma) up to the late Pleistocene (≥70 ky) in the southeastern Betics. The helicoidal geometry of the fault zone permits to shift SE-directed movement along the South Cabrera reverse fault to NW-directed shortening along the North Alhamilla reverse fault via vertical Gafarillos fault segments, in between. Since the Messinian, fault activity migrated southwards forming the South Gafarillos fault and displacing the active fault-related mountain-front from the north to the south of Sierra de Polopos; whilst recent activity of the North Alhamilla reverse fault migrated westwards. The Polopos fault zone determined the differential uplift between the Sierra Alhamilla and the Tabernas-Sorbas basin promoting the middle Pleistocene capture that occurred in the southern margin of the Sorbas basin. Continued tectonic uplift of the Sierra Alhamilla-Polopos and Cabrera anticlinoria and local subsidence associated to the Palomares fault zone in the Vera basin promoted the headward erosion of the Aguas river drainage that captured the Sorbas basin during the late Pleistocene.

A study of Quaternary structures in the Qom region, West Central Iran

NASA Astrophysics Data System (ADS)

Babaahmadi, A.; Safaei, H.; Yassaghi, A.; Vafa, H.; Naeimi, A.; Madanipour, S.; Ahmadi, M.

2010-12-01

West Central Iran comprises numerous Quaternary faults. Having either strike-slip or thrust mechanisms, these faults are potentially active and therefore capable of creating destructive earthquakes. In this paper, we use satellite images as well as field trips to identify these active faults in the Qom region. The Qom and Indes faults are the main NW-trending faults along which a Quaternary restraining step-over zone has formed. Kamarkuh, Mohsen Abad, and Ferdows anticlines are potentially active structures that formed in this restraining step-over zone. There are some thrusts and anticlines, such as the Alborz anticline and Alborz fault, which are parallel to strike-slip faults such as the Qom fault, indicating deformation partitioning in the area. In addition to NW-trending structures, there is an important NE-trending fault known as the Qomrud fault that has deformed Quaternary deposits and affected Kushk-e-Nosrat fault, Alborz anticline, and Qomrud River. The results of this study imply that the major Quaternary faults of West Central Iran and their restraining step-over zones are potentially active.

From amnesia to dementia: ERP studies of memory and language.

PubMed

Taylor, Jason R; Olichney, John M

2007-01-01

Cognitive event-related potential (ERP) studies of memory and language impairments in amnesia and Alzheimer's disease (AD) are reviewed. Well-circumscribed lesions of the medial temporal lobe (MTL) or diencephalon causing an amnestic syndrome, an inability to encode and retrieve episodic memories beyond the brief duration of working memory, appear to produce altered plasticity of the late positive P600 component, but usually spare P300 and N400 components. The neuropathology of AD affects MTL and extends to neocortical association areas, causing deficits of episodic and semantic memory. In AD dementia, the P300, N400, and P600 all commonly show abnormalities. ERP studies of individuals with mild cognitive impairment may reveal neurophysiological changes prior to the emergence of clinical deficits, which could advance the early detection and diagnosis of AD.

Probabilistic Low-Rank Multitask Learning.

PubMed

Kong, Yu; Shao, Ming; Li, Kang; Fu, Yun

2018-03-01

In this paper, we consider the problem of learning multiple related tasks simultaneously with the goal of improving the generalization performance of individual tasks. The key challenge is to effectively exploit the shared information across multiple tasks as well as preserve the discriminative information for each individual task. To address this, we propose a novel probabilistic model for multitask learning (MTL) that can automatically balance between low-rank and sparsity constraints. The former assumes a low-rank structure of the underlying predictive hypothesis space to explicitly capture the relationship of different tasks and the latter learns the incoherent sparse patterns private to each task. We derive and perform inference via variational Bayesian methods. Experimental results on both regression and classification tasks on real-world applications demonstrate the effectiveness of the proposed method in dealing with the MTL problems.

Active, capable, and potentially active faults - a paleoseismic perspective

USGS Publications Warehouse

Machette, M.N.

2000-01-01

Maps of faults (geologically defined source zones) may portray seismic hazards in a wide range of completeness depending on which types of faults are shown. Three fault terms - active, capable, and potential - are used in a variety of ways for different reasons or applications. Nevertheless, to be useful for seismic-hazards analysis, fault maps should encompass a time interval that includes several earthquake cycles. For example, if the common recurrence in an area is 20,000-50,000 years, then maps should include faults that are 50,000-100,000 years old (two to five typical earthquake cycles), thus allowing for temporal variability in slip rate and recurrence intervals. Conversely, in more active areas such as plate boundaries, maps showing faults that are <10,000 years old should include those with at least 2 to as many as 20 paleoearthquakes. For the International Lithosphere Programs' Task Group II-2 Project on Major Active Faults of the World our maps and database will show five age categories and four slip rate categories that allow one to select differing time spans and activity rates for seismic-hazard analysis depending on tectonic regime. The maps are accompanied by a database that describes evidence for Quaternary faulting, geomorphic expression, and paleoseismic parameters (slip rate, recurrence interval and time of most recent surface faulting). These maps and databases provide an inventory of faults that would be defined as active, capable, and potentially active for seismic-hazard assessments.

The buried active faults in southeastern China as revealed by the relocated background seismicity and fault plane solutions

NASA Astrophysics Data System (ADS)

Zhu, A.; Wang, P.; Liu, F.

2017-12-01

The southeastern China in the mainland corresponds to the south China block, which is characterized by moderate historical seismicity and low stain rate. Most faults are buried under thick Quaternary deposits, so it is difficult to detect and locate them using the routine geological methods. Only a few have been identified to be active in late Quaternary, which leads to relatively high potentially seismic risk to this region due to the unexpected locations of the earthquakes. We performed both hypoDD and tomoDD for the background seismicity from 2000 to 2016 to investigate the buried faults. Some buried active faults are revealed by the relocated seismicity and the velocity structure, no geologically known faults corresponding to them and no surface active evidence ever observed. The geometries of the faults are obtained by analyzing the hypocentral distribution pattern and focal mechanism. The focal mechanism solutions indicate that all the revealed faults are dominated in strike-slip mechanisms, or with some thrust components. While the previous fault investigation and detection results show that most of the Quaternary faults in southeastern China are dominated by normal movement. It suggests that there may exist two fault systems in deep and shallow tectonic regimes. The revealed faults may construct the deep one that act as the seismogenic faults, and the normal faults at shallow cannot generate the destructive earthquakes. The variation in the Curie-point depths agrees well with the structure plane of the revealed active faults, suggesting that the faults may have changed the deep structure.

Fault zone structure and inferences on past activities of the active Shanchiao Fault in the Taipei metropolis, northern Taiwan

NASA Astrophysics Data System (ADS)

Chen, C.; Lee, J.; Chan, Y.; Lu, C.

2010-12-01

The Taipei Metropolis, home to around 10 million people, is subject to seismic hazard originated from not only distant faults or sources scattered throughout the Taiwan region, but also active fault lain directly underneath. Northern Taiwan including the Taipei region is currently affected by post-orogenic (Penglai arc-continent collision) processes related to backarc extension of the Ryukyu subduction system. The Shanchiao Fault, an active normal fault outcropping along the western boundary of the Taipei Basin and dipping to the east, is investigated here for its subsurface structure and activities. Boreholes records in the central portion of the fault were analyzed to document the stacking of post- Last Glacial Maximum growth sediments, and a tulip flower structure is illuminated with averaged vertical slip rate of about 3 mm/yr. Similar fault zone architecture and post-LGM tectonic subsidence rate is also found in the northern portion of the fault. A correlation between geomorphology and structural geology in the Shanchiao Fault zone demonstrates an array of subtle geomorphic scarps corresponds to the branch fault while the surface trace of the main fault seems to be completely erased by erosion and sedimentation. Such constraints and knowledge are crucial in earthquake hazard evaluation and mitigation in the Taipei Metropolis, and in understanding the kinematics of transtensional tectonics in northern Taiwan. Schematic 3D diagram of the fault zone in the central portion of the Shanchiao Fault, displaying regional subsurface geology and its relation to topographic features.

Brain-responsive neurostimulation in patients with medically intractable mesial temporal lobe epilepsy.

PubMed

Geller, Eric B; Skarpaas, Tara L; Gross, Robert E; Goodman, Robert R; Barkley, Gregory L; Bazil, Carl W; Berg, Michael J; Bergey, Gregory K; Cash, Sydney S; Cole, Andrew J; Duckrow, Robert B; Edwards, Jonathan C; Eisenschenk, Stephan; Fessler, James; Fountain, Nathan B; Goldman, Alicia M; Gwinn, Ryder P; Heck, Christianne; Herekar, Aamar; Hirsch, Lawrence J; Jobst, Barbara C; King-Stephens, David; Labar, Douglas R; Leiphart, James W; Marsh, W Richard; Meador, Kimford J; Mizrahi, Eli M; Murro, Anthony M; Nair, Dileep R; Noe, Katherine H; Park, Yong D; Rutecki, Paul A; Salanova, Vicenta; Sheth, Raj D; Shields, Donald C; Skidmore, Christopher; Smith, Michael C; Spencer, David C; Srinivasan, Shraddha; Tatum, William; Van Ness, Paul C; Vossler, David G; Wharen, Robert E; Worrell, Gregory A; Yoshor, Daniel; Zimmerman, Richard S; Cicora, Kathy; Sun, Felice T; Morrell, Martha J

2017-06-01

Evaluate the seizure-reduction response and safety of mesial temporal lobe (MTL) brain-responsive stimulation in adults with medically intractable partial-onset seizures of mesial temporal lobe origin. Subjects with mesial temporal lobe epilepsy (MTLE) were identified from prospective clinical trials of a brain-responsive neurostimulator (RNS System, NeuroPace). The seizure reduction over years 2-6 postimplantation was calculated by assessing the seizure frequency compared to a preimplantation baseline. Safety was assessed based on reported adverse events. There were 111 subjects with MTLE; 72% of subjects had bilateral MTL onsets and 28% had unilateral onsets. Subjects had one to four leads placed; only two leads could be connected to the device. Seventy-six subjects had depth leads only, 29 had both depth and strip leads, and 6 had only strip leads. The mean follow-up was 6.1 ± (standard deviation) 2.2 years. The median percent seizure reduction was 70% (last observation carried forward). Twenty-nine percent of subjects experienced at least one seizure-free period of 6 months or longer, and 15% experienced at least one seizure-free period of 1 year or longer. There was no difference in seizure reduction in subjects with and without mesial temporal sclerosis (MTS), bilateral MTL onsets, prior resection, prior intracranial monitoring, and prior vagus nerve stimulation. In addition, seizure reduction was not dependent on the location of depth leads relative to the hippocampus. The most frequent serious device-related adverse event was soft tissue implant-site infection (overall rate, including events categorized as device-related, uncertain, or not device-related: 0.03 per implant year, which is not greater than with other neurostimulation devices). Brain-responsive stimulation represents a safe and effective treatment option for patients with medically intractable epilepsy, including patients with unilateral or bilateral MTLE who are not candidates for temporal lobectomy or who have failed a prior MTL resection. © 2017 The Authors. Epilepsia published by Wiley Periodicals, Inc. on behalf of International League Against Epilepsy.

The hazard education model in the high school science-club activities above active huge fault

NASA Astrophysics Data System (ADS)

Nakamura, R.

2017-12-01

Along the west coast of pacific ocean, includes Japan, there are huge numerous volcanoes and earthquakes. The biggest cause is their location on the border of plates. The pressure among the plates cause strains and cracks. By the island arc lines, strains make long and enormous faults. More than huge 150 faults are reported (the head quarters for earthquake research promotion, Japan, 2017). Below my working school, it is laying one of the biggest faults Nagamachi-Rifu line which is also laying under 1 million population city Sendai. Before 2011 Tohoku earthquake, one of the hugest earthquake was predicted because of the fault activities. Investigating the fault activity with our school student who live in the closest area is one of the most important hazard education. Therefore, now we are constructing the science club activity with make attention for (1) seeking fault line(s) with topographic land maps and on foot search (2) investigate boling core sample soils that was brought in our school founded. (1) Estimate of displacement of the faults on foot observation In order to seek the unknown fault line in Rifu area, at first it was needed to estimate on the maps(1:25,000 Scale Topographic Maps and Active Faults in Urban Area of Map(Sendai), Geographical Survey Institute of Japan). After that estimation, walked over the region with club students to observe slopes which was occurred by the faults activation and recorded on the maps. By observant slope gaps, there has a possibilities to have 3 or 4 fault lines that are located parallel to the known activate faults. (2) Investigate of the boling core samples above the fault. We investigated 6 columnar-shaped boling core samples which were excavated when the school has been built. The maximum depth of the samples are over 20m, some are new filled sands over original ash tephra and pumice from old volcanoes located west direction. In the club activities, we described column diagram of sediments and discussed the sediment circumstances by the sediments grain observation, however, it was impossible to describe the sediments origin of exact volcano(es).

Structural superposition in fault systems bounding Santa Clara Valley, California

USGS Publications Warehouse

Graymer, Russell W.; Stanley, Richard G.; Ponce, David A.; Jachens, Robert C.; Simpson, Robert W.; Wentworth, Carl M.

2015-01-01

Santa Clara Valley is bounded on the southwest and northeast by active strike-slip and reverse-oblique faults of the San Andreas fault system. On both sides of the valley, these faults are superposed on older normal and/or right-lateral normal oblique faults. The older faults comprised early components of the San Andreas fault system as it formed in the wake of the northward passage of the Mendocino Triple Junction. On the east side of the valley, the great majority of fault displacement was accommodated by the older faults, which were almost entirely abandoned when the presently active faults became active after ca. 2.5 Ma. On the west side of the valley, the older faults were abandoned earlier, before ca. 8 Ma and probably accumulated only a small amount, if any, of the total right-lateral offset accommodated by the fault zone as a whole. Apparent contradictions in observations of fault offset and the relation of the gravity field to the distribution of dense rocks at the surface are explained by recognition of superposed structures in the Santa Clara Valley region.

Quaternary Geology and Surface Faulting Hazard: Active and Capable Faults in Central Apennines, Italy

NASA Astrophysics Data System (ADS)

Falcucci, E.; Gori, S.

2015-12-01

The 2009 L'Aquila earthquake (Mw 6.1), in central Italy, raised the issue of surface faulting hazard in Italy, since large urban areas were affected by surface displacement along the causative structure, the Paganica fault. Since then, guidelines for microzonation were drew up that take into consideration the problem of surface faulting in Italy, and laying the bases for future regulations about related hazard, similarly to other countries (e.g. USA). More specific guidelines on the management of areas affected by active and capable faults (i.e. able to produce surface faulting) are going to be released by National Department of Civil Protection; these would define zonation of areas affected by active and capable faults, with prescriptions for land use planning. As such, the guidelines arise the problem of the time interval and general operational criteria to asses fault capability for the Italian territory. As for the chronology, the review of the international literature and regulatory allowed Galadini et al. (2012) to propose different time intervals depending on the ongoing tectonic regime - compressive or extensional - which encompass the Quaternary. As for the operational criteria, the detailed analysis of the large amount of works dealing with active faulting in Italy shows that investigations exclusively based on surface morphological features (e.g. fault planes exposition) or on indirect investigations (geophysical data), are not sufficient or even unreliable to define the presence of an active and capable fault; instead, more accurate geological information on the Quaternary space-time evolution of the areas affected by such tectonic structures is needed. A test area for which active and capable faults can be first mapped based on such a classical but still effective methodological approach can be the central Apennines. Reference Galadini F., Falcucci E., Galli P., Giaccio B., Gori S., Messina P., Moro M., Saroli M., Scardia G., Sposato A. (2012). Time intervals to assess active and capable faults for engineering practices in Italy. Eng. Geol., 139/140, 50-65.

Levelling Profiles and a GPS Network to Monitor the Active Folding and Faulting Deformation in the Campo de Dalias (Betic Cordillera, Southeastern Spain)

PubMed Central

Marín-Lechado, Carlos; Galindo-Zaldívar, Jesús; Gil, Antonio José; Borque, María Jesús; de Lacy, María Clara; Pedrera, Antonio; López-Garrido, Angel Carlos; Alfaro, Pedro; García-Tortosa, Francisco; Ramos, Maria Isabel; Rodríguez-Caderot, Gracia; Rodríguez-Fernández, José; Ruiz-Constán, Ana; de Galdeano-Equiza, Carlos Sanz

2010-01-01

The Campo de Dalias is an area with relevant seismicity associated to the active tectonic deformations of the southern boundary of the Betic Cordillera. A non-permanent GPS network was installed to monitor, for the first time, the fault- and fold-related activity. In addition, two high precision levelling profiles were measured twice over a one-year period across the Balanegra Fault, one of the most active faults recognized in the area. The absence of significant movement of the main fault surface suggests seismogenic behaviour. The possible recurrence interval may be between 100 and 300 y. The repetitive GPS and high precision levelling monitoring of the fault surface during a long time period may help us to determine future fault behaviour with regard to the existence (or not) of a creep component, the accumulation of elastic deformation before faulting, and implications of the fold-fault relationship. PMID:22319309

Faults in parts of north-central and western Houston metropolitan area, Texas

USGS Publications Warehouse

Verbeek, Earl R.; Ratzlaff, Karl W.; Clanton, Uel S.

1979-01-01

Hundreds of residential, commercial, and industrial structures in the Houston metropolitan area have sustained moderate to severe damage owing to their locations on or near active faults. Paved roads have been offset by faults at hundreds of locations, butted pipelines have been distorted by fault movements, and fault-induced gradient changes in drainage lines have raised concern among flood control engineers. Over 150 faults, many of them moving at rates of 0.5 to 2 cm/yr, have been mapped in the Houston area; the number of faults probably far exceeds this figure.This report includes a map of eight faults, in north-central and western Houston, at a scale useful for land-use planning. Seven of the faults, are known, to be active and have caused considerable damage to structures built on or near them. If the eighth fault is active, it may be of concern to new developments on the west side of Houston. A ninth feature shown on the map is regarded only as a possible fault, as an origin by faulting has not been firmly established.Seismic and drill-hold data for some 40 faults, studied in detail by various investigators have verified connections between scarps at the land surface and growth faults in the shallow subsurface. Some scarps, then, are known to be the surface manifestations of faults that have geologically long histories of movement. The degree to which natural geologic processes contribute to current fault movement, however, is unclear, for some of man’s activities may play a role in faulting as well.Evidence that current rates of fault movement far exceed average prehistoric rates and that most offset of the land surface in the Houston area has occurred only within the last 50 years indirectly suggest that fluid withdrawal may be accelerating or reinitiating movement on pre-existing faults. This conclusion, however, is based only on a coincidence in time between increased fault activity and increased rates of withdrawal of water, oil, and gas from subsurface sediments; no cause-and-effect relationship has been demonstrated. An alternative hypothesis is that natural fault movements are characterized by short—term episodicity and that Houston is experiencing the effects of a brief period of accelerated natural fault movement. Available data from monitored faults are insufficient to weigh the relative importance of natural vs. induced fault movements.

The hippocampus and memory of verbal and pictorial material.

PubMed

Papanicolaou, Andrew C; Simos, Panagiotis G; Castillo, Eduardo M; Breier, Joshua I; Katz, Jeffrey S; Wright, Anthony A

2002-01-01

Recognition of words and kaleidoscope pictures showed a double dissociation of left and right hippocampal activity using magnetic source imaging (MSI). MSI has advantages over alternative imaging techniques that measure hemodynamic changes for identifying regional changes in brain activity in real time and on an individual subject basis without the need for image subtraction. In this study, lists of words or kaleidoscope pictures were presented for memorization followed by tests of list items and foils during which brain activity was recorded. There was greater activation in the left than the right hippocampus with abstract nouns (e.g., relief) and greater activation in the right than the left hippocampus with kaleidoscope pictures. This dissociation was evident on a case by case basis. This study demonstrates the specialization of the two medial temporal lobe (MTL) regions, including the hippocampi, for mnemonic processing of verbal and pictorial items that are difficult to encode verbally.

Recent deformation along the offshore Malibu Coast, Dume, and related faults west of Point Dume, southern California

USGS Publications Warehouse

Fisher, M.A.; Langenheim, V.E.; Sorlien, C.C.; Dartnell, P.; Sliter, R.W.; Cochrane, G.R.; Wong, F.L.

2005-01-01

Offshore faults west of Point Dume, southern California, are part of an important regional fault system that extends for about 206 km, from near the city of Los Angeles westward along the south flank of the Santa Monica Mountains and through the northern Channel Islands. This boundary fault system separates the western Transverse Ranges, on the north, from the California Continental Borderland, on the south. Previous research showed that the fault system includes many active fault strands; consequently, the entire system is considered a serious potential earthquake hazard to nearby Los Angeles. We present an integrated analysis of multichannel seismic- and high-resolution seismic-reflection data and multibeam-bathymetric information to focus on the central part of the fault system that lies west of Point Dume. We show that some of the main offshore faults have cumulative displacements of 3-5 km, and many faults are currently active because they deform the seafloor or very shallow sediment layers. The main offshore fault is the Dume fault, a large north-dipping reverse fault. In the eastern part of the study area, this fault offsets the seafloor, showing Holocene displacement. Onshore, the Malibu Coast fault dips steeply north, is active, and shows left-oblique slip. The probable offshore extension of this fault is a large fault that dips steeply in its upper part but flattens at depth. High-resolution seismic data show that this fault deforms shallow sediment making up the Hueneme fan complex, indicating Holocene activity. A structure near Sycamore knoll strikes transversely to the main faults and could be important to the analysis of the regional earthquake hazard because the structure might form a boundary between earthquake-rupture segments.

Activation of preexisting transverse structures in an evolving magmatic rift in East Africa

NASA Astrophysics Data System (ADS)

Muirhead, J. D.; Kattenhorn, S. A.

2018-01-01

Inherited crustal weaknesses have long been recognized as important factors in strain localization and basin development in the East African Rift System (EARS). However, the timing and kinematics (e.g., sense of slip) of transverse (rift-oblique) faults that exploit these weaknesses are debated, and thus the roles of inherited weaknesses at different stages of rift basin evolution are often overlooked. The mechanics of transverse faulting were addressed through an analysis of the Kordjya fault of the Magadi basin (Kenya Rift). Fault kinematics were investigated from field and remote-sensing data collected on fault and joint systems. Our analysis indicates that the Kordjya fault consists of a complex system of predominantly NNE-striking, rift-parallel fault segments that collectively form a NNW-trending array of en echelon faults. The transverse Kordjya fault therefore reactivated existing rift-parallel faults in ∼1 Ma lavas as oblique-normal faults with a component of sinistral shear. In all, these fault motions accommodate dip-slip on an underlying transverse structure that exploits the Aswa basement shear zone. This study shows that transverse faults may be activated through a complex interplay among magma-assisted strain localization, preexisting structures, and local stress rotations. Rather than forming during rift initiation, transverse structures can develop after the establishment of pervasive rift-parallel fault systems, and may exhibit dip-slip kinematics when activated from local stress rotations. The Kordjya fault is shown here to form a kinematic linkage that transfers strain to a newly developing center of concentrated magmatism and normal faulting. It is concluded that recently activated transverse faults not only reveal the effects of inherited basement weaknesses on fault development, but also provide important clues regarding developing magmatic and tectonic systems as young continental rift basins evolve.

Using Video Modeling with Voiceover Instruction Plus Feedback to Train Staff to Implement Direct Teaching Procedures.

PubMed

Giannakakos, Antonia R; Vladescu, Jason C; Kisamore, April N; Reeve, Sharon A

2016-06-01

Direct teaching procedures are often an important part of early intensive behavioral intervention for consumers with autism spectrum disorder. In the present study, a video model with voiceover (VMVO) instruction plus feedback was evaluated to train three staff trainees to implement a most-to-least direct (MTL) teaching procedure. Probes for generalization were conducted with untrained direct teaching procedures (i.e., least-to-most, prompt delay) and with an actual consumer. The results indicated that VMVO plus feedback was effective in training the staff trainees to implement the MTL procedure. Although additional feedback was required for the staff trainees to show mastery of the untrained direct teaching procedures (i.e., least-to-most and prompt delay) and with an actual consumer, moderate to high levels of generalization were observed.

Attenuated anticorrelation between the default and dorsal attention networks with aging: evidence from task and rest.

PubMed

Spreng, R Nathan; Stevens, W Dale; Viviano, Joseph D; Schacter, Daniel L

2016-09-01

Anticorrelation between the default and dorsal attention networks is a central feature of human functional brain organization. Hallmarks of aging include impaired default network modulation and declining medial temporal lobe (MTL) function. However, it remains unclear if this anticorrelation is preserved into older adulthood during task performance, or how this is related to the intrinsic architecture of the brain. We hypothesized that older adults would show reduced within- and increased between-network functional connectivity (FC) across the default and dorsal attention networks. To test this hypothesis, we examined the effects of aging on task-related and intrinsic FC using functional magnetic resonance imaging during an autobiographical planning task known to engage the default network and during rest, respectively, with young (n = 72) and older (n = 79) participants. The task-related FC analysis revealed reduced anticorrelation with aging. At rest, there was a robust double dissociation, with older adults showing a pattern of reduced within-network FC, but increased between-network FC, across both networks, relative to young adults. Moreover, older adults showed reduced intrinsic resting-state FC of the MTL with both networks suggesting a fractionation of the MTL memory system in healthy aging. These findings demonstrate age-related dedifferentiation among these competitive large-scale networks during both task and rest, consistent with the idea that age-related changes are associated with a breakdown in the intrinsic functional architecture within and among large-scale brain networks. Copyright © 2016 Elsevier Inc. All rights reserved.

Specific responses of human hippocampal neurons are associated with better memory.

PubMed

Suthana, Nanthia A; Parikshak, Neelroop N; Ekstrom, Arne D; Ison, Matias J; Knowlton, Barbara J; Bookheimer, Susan Y; Fried, Itzhak

2015-08-18

A population of human hippocampal neurons has shown responses to individual concepts (e.g., Jennifer Aniston) that generalize to different instances of the concept. However, recordings from the rodent hippocampus suggest an important function of these neurons is their ability to discriminate overlapping representations, or pattern separate, a process that may facilitate discrimination of similar events for successful memory. In the current study, we explored whether human hippocampal neurons can also demonstrate the ability to discriminate between overlapping representations and whether this selectivity could be directly related to memory performance. We show that among medial temporal lobe (MTL) neurons, certain populations of neurons are selective for a previously studied (target) image in that they show a significant decrease in firing rate to very similar (lure) images. We found that a greater proportion of these neurons can be found in the hippocampus compared with other MTL regions, and that memory for individual items is correlated to the degree of selectivity of hippocampal neurons responsive to those items. Moreover, a greater proportion of hippocampal neurons showed selective firing for target images in good compared with poor performers, with overall memory performance correlated with hippocampal selectivity. In contrast, selectivity in other MTL regions was not associated with memory performance. These findings show that a substantial proportion of human hippocampal neurons encode specific memories that support the discrimination of overlapping representations. These results also provide previously unidentified evidence consistent with a unique role of the human hippocampus in orthogonalization of representations in declarative memory.

Automatic Clustering and Thickness Measurement of Anatomical Variants of the Human Perirhinal Cortex

PubMed Central

Xie, Long; Pluta, John; Wang, Hongzhi; Das, Sandhitsu R.; Mancuso, Lauren; Kliot, Dasha; Avants, Brian B.; Ding, Song-Lin; Wolk, David A.; Yushkevich, Paul A.

2015-01-01

The entorhinal cortex (ERC) and the perirhinal cortex (PRC) are subregions of the medial temporal lobe (MTL) that play important roles in episodic memory representations, as well as serving as a conduit between other neocortical areas and the hippocampus. They are also the sites where neuronal damage first occurs in Alzheimer’s disease (AD). The ability to automatically quantify the volume and thickness of the ERC and PRC is desirable because these localized measures can potentially serve as better imaging biomarkers for AD and other neurodegenerative diseases. However, large anatomical variation in the PRC makes it a challenging area for analysis. In order to address this problem, we propose an automatic segmentation, clustering, and thickness measurement approach that explicitly accounts for anatomical variation. The approach is targeted to highly anisotropic (0.4×0.4×2.0mm3) T2-weighted MRI scans that are preferred by many authors for detailed imaging of the MTL, but which pose challenges for segmentation and shape analysis. After automatically labeling MTL substructures using multi-atlas segmentation, our method clusters subjects into groups based on the shape of the PRC, constructs unbiased population templates for each group, and uses the smooth surface representations obtained during template construction to extract regional thickness measurements in the space of each subject. The proposed thickness measures are evaluated in the context of discrimination between patients with Mild Cognitive Impairment (MCI) and normal controls (NC). PMID:25320785

Lesions affecting the right hippocampal formation differentially impair short-term memory of spatial and nonspatial associations.

PubMed

Braun, Mischa; Weinrich, Christiane; Finke, Carsten; Ostendorf, Florian; Lehmann, Thomas-Nicolas; Ploner, Christoph J

2011-03-01

Converging evidence from behavioral and imaging studies suggests that within the human medial temporal lobe (MTL) the hippocampal formation may be particularly involved in recognition memory of associative information. However, it is unclear whether the hippocampal formation processes all types of associations or whether there is a specialization for processing of associations involving spatial information. Here, we investigated this issue in six patients with postsurgical lesions of the right MTL affecting the hippocampal formation and in ten healthy controls. Subjects performed a battery of delayed match-to-sample tasks with two delays (900/5,000 ms) and three set sizes. Subjects were requested to remember either single features (colors, locations, shapes, letters) or feature associations (color-location, color-shape, color-letter). In the single-feature conditions, performance of patients did not differ from controls. In the association conditions, a significant delay-dependent deficit in memory of color-location associations was found. This deficit was largely independent of set size. By contrast, performance in the color-shape and color-letter conditions was normal. These findings support the hypothesis that a region within the right MTL, presumably the hippocampal formation, does not equally support all kinds of visual memory but rather has a bias for processing of associations involving spatial information. Recruitment of this region during memory tasks appears to depend both on processing type (associative/nonassociative) and to-be-remembered material (spatial/nonspatial). Copyright © 2010 Wiley-Liss, Inc.

Imaging hydraulic fractures at Median Tectonic Line, Japan using multiply generated and scattered tube waves in a shallow VSP experiment

NASA Astrophysics Data System (ADS)

Minato, Shohei; Ghose, Ranajit; Tsuji, Takeshi; Ikeda, Michiharu; Onishi, Kozo

2016-04-01

Tube waves are low frequency guided waves that propagate along a fluid-filled borehole. The analysis of tube waves is a promising approach to image and characterize hydraulic fractures intersecting a borehole. It exploits tube waves generated by an external seismic wavefield which compresses fractures and injects fluid into the borehole. It also utilizes the attenuation of tube waves due to fluid exchange between the fracture and the borehole, which creates scattered waves (reflection and transmission). Conventional approaches consider tube waves due to a single fracture. However, when the spacing between multiple fractures is short relative to the wavelength of the tube waves, the generated and scattered tube waves interfere with each other, making it difficult to isolate the effect of a single fracture. The analysis of closely spaced fractures is important in highly fractured areas, such as a fault zone. In this study, we explore the possibility of prediction and utilization of generated and scattered tube waves due to multiple fractures. We derive a new integral equation of the full tube wavefield using 1D wavefield representation theory incorporating nonwelded interfaces. We adapt the recent developments in modeling tube wave generation/scattering at a fracture. In these models, a fracture is represented as a parallel wall or a thin poloelastic layer. This allowed us to consider the effects of a dynamic fracture aperture with fracture compliances and the permeability. The representation also leads to a new imaging method for the hydraulic fractures, using multiply-generated and scattered tube waves. This is achieved by applying an inverse operator to the observed tube waves, which focuses the tube waves to the depth where they are generated and/or scattered. The inverse operator is constructed by a tube wave Green's function with a known propagation velocity. The Median Tectonic Line (MTL) is the most significant fault in Japan, extending NE-SW for over 1000 km across the Japanese Islands. We observed multiple tube waves in a P-wave VSP experiment in a 250 m deep, vertical borehole located on the MTL at Shikoku, Japan. The borehole televiewer and the core studies show that below 40 m depth, the Sambagawa metamorphic rocks contain highly fractured zones which consist of more than 100 open fractures and more than 30 cataclasites. We predict the full tube wavefield using the values of fracture depth and thickness known from the borehole televiewer. We model the open fractures as parallel-wall fractures and the cataclasites as thin poroelastic layers. Furthermore, we estimate the depth of the hydraulic fractures by applying the inverse operator. The results show that the tube waves could be generated and scattered at these permeable structures. Our preliminary results also indicate the possibility that the effect of the open fractures is more dominant in the generation and scattering of tube waves than that of the cataclasites in this field. The formulation and the results presented in this study and the following discussion will be useful in analysis of tube waves in highly fractured zones, in order to localize and characterize hydraulic fractures.

Interactions between Polygonal Normal Faults and Larger Normal Faults, Offshore Nova Scotia, Canada

NASA Astrophysics Data System (ADS)

Pham, T. Q. H.; Withjack, M. O.; Hanafi, B. R.

2017-12-01

Polygonal faults, small normal faults with polygonal arrangements that form in fine-grained sedimentary rocks, can influence ground-water flow and hydrocarbon migration. Using well and 3D seismic-reflection data, we have examined the interactions between polygonal faults and larger normal faults on the passive margin of offshore Nova Scotia, Canada. The larger normal faults strike approximately E-W to NE-SW. Growth strata indicate that the larger normal faults were active in the Late Cretaceous (i.e., during the deposition of the Wyandot Formation) and during the Cenozoic. The polygonal faults were also active during the Cenozoic because they affect the top of the Wyandot Formation, a fine-grained carbonate sedimentary rock, and the overlying Cenozoic strata. Thus, the larger normal faults and the polygonal faults were both active during the Cenozoic. The polygonal faults far from the larger normal faults have a wide range of orientations. Near the larger normal faults, however, most polygonal faults have preferred orientations, either striking parallel or perpendicular to the larger normal faults. Some polygonal faults nucleated at the tip of a larger normal fault, propagated outward, and linked with a second larger normal fault. The strike of these polygonal faults changed as they propagated outward, ranging from parallel to the strike of the original larger normal fault to orthogonal to the strike of the second larger normal fault. These polygonal faults hard-linked the larger normal faults at and above the level of the Wyandot Formation but not below it. We argue that the larger normal faults created stress-enhancement and stress-reorientation zones for the polygonal faults. Numerous small, polygonal faults formed in the stress-enhancement zones near the tips of larger normal faults. Stress-reorientation zones surrounded the larger normal faults far from their tips. Fewer polygonal faults are present in these zones, and, more importantly, most polygonal faults in these zones were either parallel or perpendicular to the larger faults.

The mechanism of post-rift fault activities in Baiyun sag, Pearl River Mouth basin

NASA Astrophysics Data System (ADS)

Sun, Zhen; Xu, Ziying; Sun, Longtao; Pang, Xiong; Yan, Chengzhi; Li, Yuanping; Zhao, Zhongxian; Wang, Zhangwen; Zhang, Cuimei

2014-08-01

Post-rift fault activities were often observed in deepwater basins, which have great contributions to oil and gas migration and accumulation. The main causes for post-rift fault activities include tectonic events, mud or salt diapirs, and gravitational collapse. In the South China Sea continental margin, post-rift fault activities are widely distributed, especially in Baiyun sag, one of the largest deepwater sag with its main body located beneath present continental slope. During the post-rift stage, large population of faults kept active for a long time from 32 Ma (T70) till 5.5 Ma (T10). Seismic interpretation, fault analysis and analogue modeling experiments indicate that the post-rift fault activities in Baiyun sag between 32 Ma (T70) and 13.8 Ma (T30) was mainly controlled by gravity pointing to the Main Baiyun sag, which caused the faults extensive on the side facing Main Baiyun sag and the back side compressive. Around 32 Ma (T70), the breakup of the continental margin and the spreading of the South China Sea shed a combined effect of weak compression toward Baiyun sag. The gravity during post-rift stage might be caused by discrepant subsidence and sedimentation between strongly thinned sag center and wing areas. This is supported by positive relationship between sedimentation rate and fault growth index. After 13.8 Ma (T30), fault activity shows negative relationship with sedimentation rate. Compressive uplift and erosion in seismic profiles as well as negative tectonic subsiding rates suggest that the fault activity from 13.8 Ma (T30) to 5.5 Ma (T10) might be controlled by the subductive compression from the Philippine plate in the east.

Fault Activity in the Terrebonne Trough, Southeastern Louisiana: A Continuation of Salt-Withdrawal Fault Activity from the Miocene into the late Quaternary and Implication for Subsidence Hot-Spots

NASA Astrophysics Data System (ADS)

Akintomide, A. O.; Dawers, N. H.

2017-12-01

The observed displacement along faults in southeastern Louisiana has raised questions about the kinematic history of faults during the Quaternary. The Terrebonne Trough, a Miocene salt withdrawal basin, is bounded by the Golden Meadow fault zone on its northern boundary; north dipping, so-called counter-regional faults, together with a subsurface salt ridge, define its southern boundary. To date, there are relatively few published studies on fault architecture and kinematics in the onshore area of southeastern Louisiana. The only publically accessible studies, based on 2d seismic reflection profiles, interpreted faults as mainly striking east-west. Our interpretation of a 3-D seismic reflection volume, located in the northwestern Terrebonne Trough, as well as industry well log correlations define a more complex and highly-segmented fault architecture. The northwest striking Lake Boudreaux fault bounds a marsh on the upthrown block from Lake Boudreaux on the downthrown block. To the east, east-west striking faults are located at the Montegut marsh break and north of Isle de Jean Charles. Portions of the Lake Boudreaux and Isle de Jean Charles faults serve as the northern boundary of the Madison Bay subsidence hot-spot. All three major faults extend to the top of the 3d seismic volume, which is inferred to image latest Pleistocene stratigraphy. Well log correlation using 11+ shallow markers across these faults and kinematic techniques such as stratigraphic expansion indices indicate that all three faults were active in the middle(?) and late Pleistocene. Based on expansion indices, both the Montegut and Isle de Jean Charles faults were active simultaneously at various times, but with different slip rates. There are also time intervals when the Lake Boudreaux fault was slipping at a faster rate compared to the east-west striking faults. Smaller faults near the margins of the 3d volume appear to relate to nearby salt stocks, Bully Camp and Lake Barre. Our work to date suggests both salt and fault activity continued at least into the latest Pleistocene.

Shear concentration in a collision zone: kinematics of the Chihshang Fault as revealed by outcrop-scale quantification of active faulting, Longitudinal Valley, eastern Taiwan

NASA Astrophysics Data System (ADS)

Angelier, J.; Chu, H.-T.; Lee, J.-C.

1997-06-01

Repeated measurements of active deformation were carried out at three sites along the active Chihshang Fault, a segment of the Longitudinal Valley Fault zone of eastern Taiwan (the present-day plate boundary between the Philippine Sea Plate and Eurasia). Reliable annual records of displacement along an active fault, were obtained based on detailed surveys of faulted concrete structures. Along the active Chihshang Fault striking N18°E, we determined average motion vectors trending N37°W with an average shortening of 2.2 cm/yr. Thus, the transverse component of motion related to westward thrusting is 1.8 cm/yr, whereas the left-lateral strike-slip component of motion is 1.3 cm/yr. The fault dips 39-45° to the east, so that the vertical displacement is 1.5-3 cm/yr and the actual oblique offset of the fault increases at a rate of 2.7-3.7 cm/yr. This is in good agreement with the results of regional geodetic and tectonic analyses in Taiwan, and consistent with the N54°W trend of convergence between the northernmost Luzon Arc and South China revealed by GPS studies. Our study provides an example of extreme shear concentration in an oblique collision zone. At Chihshang, the whole horizontal shortening of the Longitudinal Valley Fault, 2.2 cm/yr on average, occurs across a single, narrow fault zone, so that the whole reverse slip (about 2.7-3.7 cm/yr depending on fault dip) was entirely recorded by walls 20-200 m long where faults are tightly localized. This active faulting accounts for more than one fourth (27%) of the total shortening between the Luzon Arc and South China recorded through GPS analyses. Further surveys should indicate whether the decreasing shortening velocity across the fault is significant (revealing increasing earthquake risk due to stress accumulation) or not (revealing continuing fault creep and 'weak' behaviour of the Chihshang Fault).

[X-ray diffraction and infrared spectrum analysis of fault gouge in Wenchuan seismic belt].

PubMed

Wang, Zheng-Yang; Cao, Jian-Jin; Luo, Song-Ying; Liao, Yi-Peng

2014-05-01

Wenchuan earthquake produced a series of co-seismic surface ruptures in Leigu and Zhaojiagou, and we collected samples of co-seismic fault gouge in the surface ruptures as well as the old gouge in the fault of Nanba. Testing The new and old fault gouge was tested with X-ray diffraction and infrared absorption spectra, and its characteristics such as mineral compositions, clay mineral contents and combinations were comprehensively analyzed. The results display obvious differences between the new and old fault gouge, showing that the old fault gouge is mainly composed of wall rock debris or milled powders, while the main components of new fault gouge are clay minerals. The assemblage of clay minerals composition shows that the environment of the fault activity was mainly warm and humid, and the clay minerals were mainly transformed by low temperature and low pressure dynamic metamorphism. And this also partly indicates that the latest way of the fault activity in this area may be a creeping. However the previous researches on the fault gouge of Wenchuan earthquake fault zone are mainly focused on its mechanical properties as well as its texture and structure, the research in this paper is to determine the physical and chemical environment of fault activity through the mineral compositions and clay mineral contents in the fault gouge characteristics, and this research has important scientific significance to the researches on the evolution of the fault environment and the activity mechanism of the earthquake.

Active Fault Near-Source Zones Within and Bordering the State of California for the 1997 Uniform Building Code

USGS Publications Warehouse

Petersen, M.D.; Toppozada, Tousson R.; Cao, T.; Cramer, C.H.; Reichle, M.S.; Bryant, W.A.

2000-01-01

The fault sources in the Project 97 probabilistic seismic hazard maps for the state of California were used to construct maps for defining near-source seismic coefficients, Na and Nv, incorporated in the 1997 Uniform Building Code (ICBO 1997). The near-source factors are based on the distance from a known active fault that is classified as either Type A or Type B. To determine the near-source factor, four pieces of geologic information are required: (1) recognizing a fault and determining whether or not the fault has been active during the Holocene, (2) identifying the location of the fault at or beneath the ground surface, (3) estimating the slip rate of the fault, and (4) estimating the maximum earthquake magnitude for each fault segment. This paper describes the information used to produce the fault classifications and distances.

Active fault databases: building a bridge between earthquake geologists and seismic hazard practitioners, the case of the QAFI v.3 database

NASA Astrophysics Data System (ADS)

García-Mayordomo, Julián; Martín-Banda, Raquel; Insua-Arévalo, Juan M.; Álvarez-Gómez, José A.; Martínez-Díaz, José J.; Cabral, João

2017-08-01

Active fault databases are a very powerful and useful tool in seismic hazard assessment, particularly when singular faults are considered seismogenic sources. Active fault databases are also a very relevant source of information for earth scientists, earthquake engineers and even teachers or journalists. Hence, active fault databases should be updated and thoroughly reviewed on a regular basis in order to keep a standard quality and uniformed criteria. Desirably, active fault databases should somehow indicate the quality of the geological data and, particularly, the reliability attributed to crucial fault-seismic parameters, such as maximum magnitude and recurrence interval. In this paper we explain how we tackled these issues during the process of updating and reviewing the Quaternary Active Fault Database of Iberia (QAFI) to its current version 3. We devote particular attention to describing the scheme devised for classifying the quality and representativeness of the geological evidence of Quaternary activity and the accuracy of the slip rate estimation in the database. Subsequently, we use this information as input for a straightforward rating of the level of reliability of maximum magnitude and recurrence interval fault seismic parameters. We conclude that QAFI v.3 is a much better database than version 2 either for proper use in seismic hazard applications or as an informative source for non-specialized users. However, we already envision new improvements for a future update.

3-D GPR data analysis for high-resolution imaging of shallow subsurface faults: the Mt Vettore case study (Central Apennines, Italy)

NASA Astrophysics Data System (ADS)

Ercoli, Maurizio; Pauselli, Cristina; Frigeri, Alessandro; Forte, Emanuele; Federico, Costanzo

2014-07-01

The activation of Late Quaternary faults in the Central Apennines (Italy) could generate earthquakes with magnitude of about 6.5, and the Monte Vettore fault system probably belongs to the same category of seismogenetic faults. Such structure has been defined `silent', because of its geological and geomorphological evidences of past activation, but the absence of historical records in the seismic catalogues to be associated with its activation. The `Piano di Castelluccio' intramountain basin, resulting from the Quaternary activity of normal faults, is characterized by a secondary fault strand highlighted by a NW-SE fault scarp: it has been already studied through palaeoseismological trenches, which highlighted evidences of Quaternary shallow faulting due to strong earthquakes, and through a 2-D ground penetrating radar (GPR) survey, showing the first geophysical signature of faulting for this site. Within the same place, a 3-D GPR volume over a 20 × 20 m area has been collected. The collection of radar echoes in three dimensions allows to map both the vertical and lateral continuity of shallow geometries of the fault zone (Fz), imaging features with high resolution, ranging from few metres to centimetres and therefore imaging also local variations at the microscale. Several geophysical markers of faulting, already highlighted on this site, have been taken as reference to plan the 3-D survey. In this paper, we provide the first 3-D subsurface imaging of an active shallow fault belonging to the Umbria-Marche Apennine highlighting the subsurface fault geometry and the stratigraphic sequence up to a depth of about 5 m. From our data, geophysical faulting signatures are clearly visible in three dimensions: diffraction hyperbolas, truncations of layers, local attenuated zones and varying dip of the layers have been detected within the Fz. The interpretation of the 3-D data set provided qualitative and quantitative geological information in addition to the fault location, like its geometry, boundaries and an estimation of the fault throw.

Up-dip partitioning of displacement components on the oblique-slip Clarence Fault, New Zealand

NASA Astrophysics Data System (ADS)

Nicol, Andrew; Van Dissen, Russell

2002-09-01

Active strike-slip faults in New Zealand occur within an obliquely-convergent plate boundary zone. Although the traces of these faults commonly delineate the base of mountain ranges, they do not always accommodate significant shortening at the free surface. Along the active trace of Clarence Fault in northeastern South Island, New Zealand, displaced landforms and slickenside striations indicate predominantly horizontal displacements at the ground surface, and a right-lateral slip rate of ca. 3.5-5 mm/year during the Holocene. The Inland Kaikoura mountain range occupies the hanging wall of the fault and rises steeply from the active trace to altitudes of ca. 3 km. The geomorphology of the range indicates active uplift and mountain building, which is interpreted to result, in part, from a vertical component of fault slip at depth. These data are consistent with the fault accommodating oblique-slip at depth aligned parallel to the plate-motion vector and compatible with regional geodetic data and earthquake focal-mechanisms. Oblique-slip on the Clarence Fault at depth is partitioned at the free surface into: (1) right-lateral displacement on the fault, and (2) hanging wall uplift produced by distributed displacement on small-scale faults parallel to the main fault. Decoupling of slip components reflects an up-dip transfer of fault throw to an off-fault zone of distributed uplift. Such zones are common in the hanging walls of thrusts and reverse faults, and support the idea that the dip of the oblique-slip Clarence Fault steepens towards the free surface.

Preservation of amorphous ultrafine material: A proposed proxy for slip during recent earthquakes on active faults

NASA Astrophysics Data System (ADS)

Hirono, Tetsuro; Asayama, Satoru; Kaneki, Shunya; Ito, Akihiro

2016-11-01

The criteria for designating an “Active Fault” not only are important for understanding regional tectonics, but also are a paramount issue for assessing the earthquake risk of faults that are near important structures such as nuclear power plants. Here we propose a proxy, based on the preservation of amorphous ultrafine particles, to assess fault activity within the last millennium. X-ray diffraction data and electron microscope observations of samples from an active fault demonstrated the preservation of large amounts of amorphous ultrafine particles in two slip zones that last ruptured in 1596 and 1999, respectively. A chemical kinetic evaluation of the dissolution process indicated that such particles could survive for centuries, which is consistent with the observations. Thus, preservation of amorphous ultrafine particles in a fault may be valuable for assessing the fault’s latest activity, aiding efforts to evaluate faults that may damage critical facilities in tectonically active zones.

Along-strike variations of geometry and kinematics on the border fault of Nanpu sag, Bohai Bay Basin

NASA Astrophysics Data System (ADS)

Zhang, C.; Ren, J.; Liu, X.; Sun, Z.; Su, M.

2010-12-01

Nanpu sag is located in the north-eastern portion of the Huanghua depression, covering an area of approximately 1900km2, and comprises one of the most important petroliferous basins of the Bohai Bay Basin. The Nanpu sag is bordered by two master faults with long-term activity: the Xi’nanzhuang (XNZ) and Bogezhuang (BGZ) fault. By analysis of horizontal slices, gravity anomaly map and seismic reflection sections, we found there is no cutting relationship, and thus considered the XNZ and BGZ fault as a same one. However it showed striking differences between the XNZ and BGZ segment in fault occurrence, fault throw and residual formation thickness and so on. The BGZ fault was NW trending fault with a steep inclination. Taken section across the northern region in Nanpu sag for example, its controlling depocenter is located in eastern subsag (Fig.1); the XNZ fault was a NE fault and displayed a Shovel-shaped to plate-like geometry, with its controlling depocenter located in western subsag. We qualitify the fault throw, showing that the XNZ fault strongly acted during the sedimentary period of Es3-Es2, while the BGZ fault presented weak activity, and especially during Es31 submember-Es2 member, the XNZ fault acted so strongly that the hanging wall of BGZ fault was tilt-lifted and suffered erosion (Fig.1), which created Es1 uncomformity; The BGZ fault acted strongly during the sedimentary period of Es1-Ed, which led the hanging wall of XNZ fault to be tilt-lifted. Controlled by such segmented activity of the whole border fault, which we suggested a "seesaw" model for its evolution, the northern part in the Nanpu sag experienced an alternative variation between a deposition center and an erosion region after tilt-lifting. Combination of the sediment stacking patterns, we further classified the history of "seesaw" activities into four stages: 1) Early double-break stage (Es35-Es31), both of the XNZ and BGZ fault acted; 2) Middle the XNZ segment throw and the BGZ tilting (Es2); 3) Late the XNZ segment tilting and BGZ throw (Es1-Ed3); 4) End weak double-break stage (Ed2-Present), the whole fault acted weakly and were superposed by neotectonic movement. Fig.1 Seesaw activity of the whole border fault

Gently dipping normal faults identified with Space Shuttle radar topography data in central Sulawesi, Indonesia, and some implications for fault mechanics

USGS Publications Warehouse

Spencer, J.E.

2011-01-01

Space-shuttle radar topography data from central Sulawesi, Indonesia, reveal two corrugated, domal landforms, covering hundreds to thousands of square kilometers, that are bounded to the north by an abrupt transition to typical hilly to mountainous topography. These domal landforms are readily interpreted as metamorphic core complexes, an interpretation consistent with a single previous field study, and the abrupt northward transition in topographic style is interpreted as marking the trace of two extensional detachment faults that are active or were recently active. Fault dip, as determined by the slope of exhumed fault footwalls, ranges from 4?? to 18??. Application of critical-taper theory to fault dip and hanging-wall surface slope, and to similar data from several other active or recently active core complexes, suggests a theoretical limit of three degrees for detachment-fault dip. This result appears to conflict with the dearth of seismological evidence for slip on faults dipping less than ~. 30??. The convex-upward form of the gently dipping fault footwalls, however, allows for greater fault dip at depths of earthquake initiation and dominant energy release. Thus, there may be no conflict between seismological and mapping studies for this class of faults. ?? 2011 Elsevier B.V.

Earthquake disaster mitigation of Lembang Fault West Java with electromagnetic method

NASA Astrophysics Data System (ADS)

Widodo

2015-04-01

The Lembang fault is located around eight kilometers from Bandung City, West Java, Indonesia. The existence of this fault runs through densely populated settlement and tourism area. It is an active fault structure with increasing seismic activity where the 28 August 2011 earthquake occurred. The seismic response at the site is strongly influenced by local geological conditions. The ambient noise measurements from the western part of this fault give strong implication for a complex 3-D tectonic setting. Hence, near surface Electromagnetic (EM) measurements are carried out to understand the location of the local active fault of the research area. Hence, near surface EM measurements are carried out to understand the location of the local active fault and the top of the basement structure of the research area. The Transientelectromagnetic (TEM) measurements are carried out along three profiles, which include 35 TEM soundings. The results indicate that TEM data give detailed conductivity distribution of fault structure in the study area.

Earthquake disaster mitigation of Lembang Fault West Java with electromagnetic method

DOE Office of Scientific and Technical Information (OSTI.GOV)

Widodo, E-mail: widodo@gf.itb.ac.id

The Lembang fault is located around eight kilometers from Bandung City, West Java, Indonesia. The existence of this fault runs through densely populated settlement and tourism area. It is an active fault structure with increasing seismic activity where the 28 August 2011 earthquake occurred. The seismic response at the site is strongly influenced by local geological conditions. The ambient noise measurements from the western part of this fault give strong implication for a complex 3-D tectonic setting. Hence, near surface Electromagnetic (EM) measurements are carried out to understand the location of the local active fault of the research area. Hence,more » near surface EM measurements are carried out to understand the location of the local active fault and the top of the basement structure of the research area. The Transientelectromagnetic (TEM) measurements are carried out along three profiles, which include 35 TEM soundings. The results indicate that TEM data give detailed conductivity distribution of fault structure in the study area.« less

Mesial temporal lobe morphology in intractable pediatric epilepsy: so-called hippocampal malrotation, associated findings, and relevance to presurgical assessment.

PubMed

Leach, James L; Awwad, Reem; Greiner, Hansel M; Vannest, Jennifer J; Miles, Lili; Mangano, Francesco T

2016-06-01

OBJECTIVE Diagnostic criteria for hippocampal malrotation (HIMAL) on brain MRI typically include a rounded hippocampus, vertical collateral sulcus, and architectural blurring. Relationship to epileptogenesis remains speculative, and usefulness for surgical guidance is unknown. The study was performed to determine the prevalence of hippocampal rotational anomalies in a cohort of pediatric patients with intractable epilepsy undergoing evaluation for surgery and to determine the significance of this finding in the context of surgical planning. METHODS Forty-eight surgically treated children with intractable epilepsy were compared with matched healthy subjects; reviewers were blinded to surgical side. Each temporal lobe was evaluated for rounded hippocampus, blurring, vertical collateral sulcus, wide choroidal fissure, enlarged temporal horn, low fornix, hippocampal signal, and findings of hippocampal sclerosis. A mesial temporal lobe (MTL) score was calculated by summing the number of features, and the collateral sulcus angle (CSA) was measured in each temporal lobe. Surgical side, pathological diagnosis, and imaging findings elsewhere in the brain were tabulated. Presence of HIMAL, associated imaging features, and MTL score were compared between sides, between epilepsy and control groups, in relationship to side of surgery, and in relationship to postoperative outcome. RESULTS Only 3 epilepsy patients (6.2%) and no controls exhibited all 3 features of HIMAL (p = 0.12). Eight of 48 (16.7%) epilepsy versus 2 of 48 (4.6%) control subjects had both a rounded hippocampus and vertical collateral sulcus (suggesting HIMAL) (p = 0.045). In control and epilepsy subjects, most findings were more prevalent on the left, and the left CSA was more vertical (p < 0.0001). Epilepsy subjects had higher MTL scores (z = -2.95, p = 0.002) and more acute CSAs (p = 0.04) than controls. Only lateralizing raw MTL score had a significant association with surgical side (p = 0.03, OR 7.33); however, this was not significant when hippocampal sclerosis cases were excluded. HIMAL findings were more prevalent and MTL scores were higher in patients with resections involving the temporal lobes. On group analysis, HIMAL findings did not predict eventual surgical side and did not predict outcome, although the numbers are small. In 4 patients the abnormally rotated hippocampus was resected and showed hippocampal sclerosis and/or dysplastic changes on histopathology. All of these patients had a good outcome after surgery. CONCLUSIONS While increased in prevalence in children with intractable epilepsy, imaging findings of HIMAL did not have preoperative lateralizing utility in this group. Findings of HIMAL (including round hippocampus, architectural blurring, and vertical collateral sulcus) did not predict outcome after surgery, although the small number of patients with these findings limits evaluation. In the small number of patients in which the malrotated hippocampus was removed, outcome was good. Further research is needed to continue to define this association in children with intractable epilepsy, focusing on a temporal lobe cohort.

E-W strike slip shearing of Kinwat granitoid at South East Deccan Volcanic Province, Kinwat, Maharashtra, India

NASA Astrophysics Data System (ADS)

Kaplay, R. D.; Kumar, T. Vijay; Mukherjee, Soumyajit; Wesanekar, P. R.; Babar, Md; Chavan, Sumeet

2017-07-01

We study the margin of South East Deccan Volcanic Province around Kinwat lineament, Maharashtra, India, which is NW extension of the Kaddam Fault. Structural field studies document ˜ E-W strike-slip mostly brittle faults from the basement granite. We designate this as `Western boundary East Dharwar Craton Strike-slip Zone' (WBEDCSZ). At local level, the deformation regime from Kinwat, Kaddam Fault, micro-seismically active Nanded and seismically active Killari corroborate with the nearby lineaments. Morphometric analyses suggest that the region is moderately tectonically active. The region of intense strike-slip deformation lies between seismically active fault along Tapi in NW and Bhadrachalam in the SE part of the Kaddam Fault/lineament. The WBEDCSZ with the surface evidences of faulting, presence of a major lineaments and intersection of faults could be a zone of intraplate earthquake.

Imaging the complexity of an active normal fault system: The 1997 Colfiorito (central Italy) case study

USGS Publications Warehouse

Chiaraluce, L.; Ellsworth, W.L.; Chiarabba, C.; Cocco, M.

2003-01-01

Six moderate magnitude earthquakes (5 < Mw < 6) ruptured normal fault segments of the southern sector of the North Apennine belt (central Italy) in the 1997 Colfiorito earthquake sequence. We study the progressive activation of adjacent and nearby parallel faults of this complex normal fault system using ???1650 earthquake locations obtained by applying a double-difference location method, using travel time picks and waveform cross-correlation measurements. The lateral extent of the fault segments range from 5 to 10 km and make up a broad, ???45 km long, NW trending fault system. The geometry of each segment is quite simple and consists of planar faults gently dipping toward SW with an average dip of 40??-45??. The fault planes are not listric but maintain a constant dip through the entire seismogenic volume, down to 8 km depth. We observe the activation of faults on the hanging wall and the absence of seismicity in the footwall of the structure. The observed fault segmentation appears to be due to the lateral heterogeneity of the upper crust: preexisting thrusts inherited from Neogene's compressional tectonic intersect the active normal faults and control their maximum length. The stress tensor obtained by inverting the six main shock focal mechanisms of the sequence is in agreement with the tectonic stress active in the inner chain of the Apennine, revealing a clear NE trending extension direction. Aftershock focal mechanisms show a consistent extensional kinematics, 70% of which are mechanically consistent with the main shock stress field.

Fracture zone drilling through Atotsugawa fault in central Japan - geological and geophysical structure -

NASA Astrophysics Data System (ADS)

Omura, K.; Yamashita, F.; Yamada, R.; Matsuda, T.; Fukuyama, E.; Kubo, A.; Takai, K.; Ikeda, R.; Mizuochi, Y.

2004-12-01

Drilling is an effective method to investigate the structure and physical state in and around the active fault zone, such as, stress and strength distribution, geological structure and materials properties. In particular, the structure in the fault zone is important to understand where and how the stress accumulates during the earthquake cycle. In previous studies, we did integrate investigation on active faults in central Japan by drilling and geophysical prospecting. Those faults are estimated to be at different stage in the earthquake cycle, i.e., Nojima fault which appeared on the surface by the 1995 Great Kobe earthquake (M=7.2), the Neodani fault which appeared by the 1891 Nobi earth-quake (M=8.0), the Atera fault, of which some parts have seemed to be dislocated by the 1586 Tensyo earthquake (M=7.9), and Gofukuji Fault that is considered to have activated about 1200 years ago. Each faults showed characteristic features of fracture zone structure according to their geological and geophysical situations. In a present study, we did core recovery and down hole measurements at the Atotsugawa fault, central Japan, that is considered to have activated at 1858 Hida earthquake (M=7.0). The Atotsugawa fault is characterized by active seismicity along the fault. But, at the same time, the shallow region in the central segment of the fault seems to have low seismicity. The high seismicity segment and low seismicity segments may have different mechanical, physical and material properties. A 350m depth borehole was drilled vertically beside the surface trace of the fault in the low seismicity segment. Recovered cores were overall heavily fractured and altered rocks. In the cores, we observed many shear planes holding fault gouge. Logging data showed that the apparent resistance was about 100 - 600 ohm-m, density was about 2.0 - 2.5g/cm3, P wave velocity was approximately 3.0 - 4.0 km/sec, neutron porosity was 20 - 40 %. Results of physical logging show features of fault fracture zone that were the same as the fault fracture zones of other active faults that we have drilled previously. By the BHTV logging, we detected many fractures of which the strikes are not only parallel to the fault trace bur also oblique to the fault trace. The observations of cores and logging data indicate that the borehole passed in the fracture zone down to the bottom, and that the fracture zone has complicate internal structure including foliation not parallel to the fault trace. The core samples are significant for further investigation on material properties in the fracture zone. And we need data of geophysical prospecting to infer the deeper structure of the fracture zone.

Age-related differences in memory-encoding fMRI responses after accounting for decline in vascular reactivity

PubMed Central

Liu, Peiying; Hebrank, Andrew C.; Rodrigue, Karen M.; Kennedy, Kristen M.; Section, Jarren; Park, Denise C.; Lu, Hanzhang

2013-01-01

BOLD fMRI has provided a wealth of information about the aging brain. A common finding is that posterior regions of the brain manifest an age-related decrease in activation while the anterior regions show an age-related increase. Several neurocognitive models have been proposed to interpret these findings. However, one issue that has not been sufficiently considered to date is that the BOLD signal is based on vascular responses secondary to neural activity. Thus the above findings could be in part due to a vascular change, especially in view of the expected decline of vascular health with age. In the present study, we aim to examine age-related differences in memory-encoding fMRI response in the context of vascular aging. One hundred and thirty healthy subjects ranging from 20 to 89 years old underwent a scene-viewing fMRI task and, in the same session, cerebrovascular reactivity (CVR) was measured in each subject using a CO2-inhalation task. Without accounting for the influence of vascular changes, the task-activated fMRI signal showed the typical age-related decrease in visual cortex and medial temporal lobe (MTL), but manifested an increase in the right inferior frontal gyrus (IFG). In the same individuals, an age-related CVR reduction was observed in all of these regions. We then used a previously proposed normalization approach to calculate a CVR-corrected fMRI signal, which was defined as the uncorrected signal divided by CVR. Based on the CVR-corrected fMRI signal, an age-related increase is now seen in both the left and right side of IFG; and no brain regions showed a signal decrease with age. We additionally used a model-based approach to examine the fMRI data in the context of CVR, which again suggested an age-related change in the two frontal regions, but not in the visual and MTL regions. PMID:23624491

Functional MRI study of diencephalic amnesia in Wernicke-Korsakoff syndrome.

PubMed

Caulo, M; Van Hecke, J; Toma, L; Ferretti, A; Tartaro, A; Colosimo, C; Romani, G L; Uncini, A

2005-07-01

Anterograde amnesia in Wernicke-Korsakoff syndrome is associated with diencephalic lesions, mainly in the anterior thalamic nuclei. Whether diencephalic and temporal lobe amnesias are distinct entities is still not clear. We investigated episodic memory for faces using functional MRI (fMRI) in eight controls and in a 34-year-old man with Wernicke-Korsakoff syndrome and diencephalic lesions but without medial temporal lobe (MTL) involvement at MRI. fMRI was performed with a 1.5 tesla unit. Three dual-choice tasks were employed: (i) face encoding (18 faces were randomly presented three times and subjects were asked to memorize the faces); (ii) face perception (subjects indicated which of two faces matched a third face); and (iii) face recognition (subjects indicated which of two faces belonged to the group they had been asked to memorize during encoding). All activation was greater in the right hemisphere. In controls both the encoding and recognition tasks activated two hippocampal regions (anterior and posterior). The anterior hippocampal region was more activated during recognition. Activation in the prefrontal cortex was greater during recognition. In the subject with Wernicke-Korsakoff syndrome, fMRI did not show hippocampal activation during either encoding or recognition. During recognition, although behavioural data showed defective retrieval, the prefrontal regions were activated as in controls, except for the ventrolateral prefrontal cortex. fMRI activation of the visual cortices and the behavioural score on the perception task indicated that the subject with Wernicke-Korsakoff syndrome perceived the faces, paid attention to the task and demonstrated accurate judgement. In the subject with Wernicke-Korsakoff syndrome, although the anatomical damage does not involve the MTL, the hippocampal memory encoding has been lost, possibly as a consequence of the hippocampal-anterior thalamic axis involvement. Anterograde amnesia could therefore be the expression of damage to an extended hippocampal system, and the distinction between temporal lobe and diencephalic amnesia has limited value. In the subject with Wernicke-Korsakoff syndrome, the preserved dorsolateral prefrontal cortex activation during incorrect recognition suggests that this region is more involved in either the orientation or attention at retrieval than in retrieval. The lack of activation of the prefrontal ventrolateral cortex confirms the role of this area in episodic memory formation.

Fluid-rock interaction during a large earthquake recorded in fault gouge: A case study of the Nojima fault, Japan

NASA Astrophysics Data System (ADS)

Bian, D.; Lin, A.

2016-12-01

Distinguishing the seismic ruptures during the earthquake from a lot of fractures in borehole core is very important to understand rupture processes and seismic efficiency. In particular, a great earthquake like the 1995 Mw 7.2 Kobe earthquake, but again, evidence has been limited to the grain size analysis and the color of fault gouge. In the past two decades, increasing geological evidence has emerged that seismic faults and shear zones within the middle to upper crust play a crucial role in controlling the architectures of crustal fluid migration. Rock-fluid interactions along seismogenic faults give us a chance to find the seismic ruptures from the same event. Recently, a new project of "Drilling into Fault Damage Zone" has being conducted by Kyoto University on the Nojima Fault again after 20 years of the 1995 Kobe earthquake for an integrated multidisciplinary study on the assessment of activity of active faults involving active tectonics, geochemistry and geochronology of active fault zones. In this work, we report on the signature of slip plane inside the Nojima Fault associated with individual earthquakes on the basis of trace element and isotope analyses. Trace element concentrations and 87Sr/86Sr ratios of fault gouge and host rocks were determined by an inductively coupled plasma mass spectrometer (ICP-MS) and thermal ionization mass spectrometry (TIMS). Samples were collected from two trenches and an outcrop of Nojima Fault which. Based on the geochemical result, we interpret these geochemical results in terms of fluid-rock interactions recorded in fault friction during earthquake. The trace-element enrichment pattern of the slip plane can be explained by fluid-rock interactions at high temperature. It also can help us find the main coseismic fault slipping plane inside the thick fault gouge zone.

Ultrahigh-Performance Liquid Chromatography (UHPLC)-Tandem Mass Spectrometry (MS/MS) Quantification of Nine Target Indoles in Sparkling Wines.

PubMed

Tudela, Rebeca; Ribas-Agustí, Albert; Buxaderas, Susana; Riu-Aumatell, Montserrat; Castellari, Massimo; López-Tamames, Elvira

2016-06-15

An ultrahigh-performance liquid chromatography (UHPLC)-tandem mass spectrometry (MS/MS) method was developed for the simultaneous determination of nine target indoles in sparkling wines. The proposed method requires minimal sample pretreatment, and its performance parameters (accuracy, repeatability, LOD, and matrix effect) indicate that it is suitable for routine analysis. Four indoles were found at detectable levels in commercial Cava samples: 5-methoxytryptophol (5MTL), tryptophan (TRP), tryptophan ethyl ester (TEE), and N-acetylserotonin (NSER). Two of them, NSER and 5MTL, are reported here for the first time in sparkling wines, with values of 0.3-2 and 0.29-29.2 μg/L, respectively. In the same samples, the contents of melatonin (MEL), serotonin (SER), 5-hydroxytryptophan (5-OHTRP), 5-hydroxyindole-3-acetic acid (5OHIA), and 5-methoxy-3-indoleacetic acid (5MIA) were all below the corresponding limits of detection.

Influence of channel base current and varying return stroke speed on the calculated fields of three important return stroke models

NASA Technical Reports Server (NTRS)

Thottappillil, Rajeev; Uman, Martin A.; Diendorfer, Gerhard

1991-01-01

Compared here are the calculated fields of the Traveling Current Source (TCS), Modified Transmission Line (MTL), and the Diendorfer-Uman (DU) models with a channel base current assumed in Nucci et al. on the one hand and with the channel base current assumed in Diendorfer and Uman on the other hand. The characteristics of the field wave shapes are shown to be very sensitive to the channel base current, especially the field zero crossing at 100 km for the TCS and DU models, and the magnetic hump after the initial peak at close range for the TCS models. Also, the DU model is theoretically extended to include any arbitrarily varying return stroke speed with height. A brief discussion is presented on the effects of an exponentially decreasing speed with height on the calculated fields for the TCS, MTL, and DU models.

Evolution of pathogenicity and sexual reproduction in eight Candida genomes

PubMed Central

Butler, Geraldine; Rasmussen, Matthew D.; Lin, Michael F.; Santos, Manuel A.S.; Sakthikumar, Sharadha; Munro, Carol A.; Rheinbay, Esther; Grabherr, Manfred; Forche, Anja; Reedy, Jennifer L.; Agrafioti, Ino; Arnaud, Martha B.; Bates, Steven; Brown, Alistair J.P.; Brunke, Sascha; Costanzo, Maria C.; Fitzpatrick, David A.; de Groot, Piet W. J.; Harris, David; Hoyer, Lois L.; Hube, Bernhard; Klis, Frans M.; Kodira, Chinnappa; Lennard, Nicola; Logue, Mary E.; Martin, Ronny; Neiman, Aaron M.; Nikolaou, Elissavet; Quail, Michael A.; Quinn, Janet; Santos, Maria C.; Schmitzberger, Florian F.; Sherlock, Gavin; Shah, Prachi; Silverstein, Kevin; Skrzypek, Marek S.; Soll, David; Staggs, Rodney; Stansfield, Ian; Stumpf, Michael P H; Sudbery, Peter E.; Thyagarajan, Srikantha; Zeng, Qiandong; Berman, Judith; Berriman, Matthew; Heitman, Joseph; Gow, Neil A. R.; Lorenz, Michael C.; Birren, Bruce W.; Kellis, Manolis; Cuomo, Christina A.

2009-01-01

Candida species are the most common cause of opportunistic fungal infection worldwide. We report the genome sequences of six Candida species and compare these and related pathogens and nonpathogens. There are significant expansions of cell wall, secreted, and transporter gene families in pathogenic species, suggesting adaptations associated with virulence. Large genomic tracts are homozygous in three diploid species, possibly resulting from recent recombination events. Surprisingly, key components of the mating and meiosis pathways are missing from several species. These include major differences at the Mating-type loci (MTL); Lodderomyces elongisporus lacks MTL, and components of the a1/alpha2 cell identity determinant were lost in other species, raising questions about how mating and cell types are controlled. Analysis of the CUG leucine to serine genetic code change reveals that 99% of ancestral CUG codons were erased and new ones arose elsewhere. Lastly, we revise the C. albicans gene catalog, identifying many new genes. PMID:19465905

Identifying buried segments of active faults in the northern Rio Grande Rift using aeromagnetic, LiDAR,and gravity data, south-central Colorado, USA

USGS Publications Warehouse

Grauch, V.J.S.; Ruleman, Chester A.

2013-01-01

Combined interpretation of aeromagnetic and LiDAR data builds on the strength of the aeromagnetic method to locate normal faults with significant offset under cover and the strength of LiDAR interpretation to identify the age and sense of motion of faults. Each data set helps resolve ambiguities in interpreting the other. In addition, gravity data can be used to infer the sense of motion for totally buried faults inferred solely from aeromagnetic data. Combined interpretation to identify active faults at the northern end of the San Luis Basin of the northern Rio Grande rift has confirmed general aspects of previous geologic mapping but has also provided significant improvements. The interpretation revises and extends mapped fault traces, confirms tectonic versus fluvial origins of steep stream banks, and gains additional information on the nature of active and potentially active partially and totally buried faults. Detailed morphology of surfaces mapped from the LiDAR data helps constrain ages of the faults that displace the deposits. The aeromagnetic data provide additional information about their extents in between discontinuous scarps and suggest that several totally buried, potentially active faults are present on both sides of the valley.

Thin CVD-diamond RF Pill-Box vacuum windows for LHCD systems

NASA Astrophysics Data System (ADS)

Ravera, G. L.; Ceccuzzi, S.; Cardinali, A.; Cesario, R.; Mirizzi, F.; Schettini, G.; Tuccillo, A. A.

2014-02-01

The preliminary assessment of a Lower Hybrid Current Drive (LHCD) system for the DEMOnstration power plant (DEMO) is mainly focused on the R&D needs of the less conventional RF components of the Main Transmission Line (MTL) and of the launcher. 500 kW, CW klystrons will be used to deliver the RF power to independent Passive Active Multijunction (PAM) launcher modules at 5 GHz. This paper describes the criteria followed to investigate the optimum solution for the RF window used as vacuum barrier between the MTL and the launcher, an open issue in the LHCD system for ITER too. The best candidate, capable of withstanding a power level of, or above, 0.5 MW in CW operation and to satisfy the electrical and thermonuclear requirements, is a Pill-Box assembly, based on a thin single disk of CVD-diamond as dielectric, water cooled at the edge. A thickness of 3 mm, much shorter than half a wavelength of the TE°11 mode in the dielectric as in the conventional window (unfeasible and too expensive with CVD-diamond at these frequencies), is sufficient to limit the exerted stress at the edge under the fracture stress for a maximum pressure applied of 0.9 MPa. In this paper the simulation results of conventional and thin CVD-diamond vacuum windows are presented comparing S-parameters, losses and electric fields in both matching condition and with VSWR = 2, using WR284 and WR229 as input/output rectangular waveguide.

Millennial strain partitioning revealed by 36Cl cosmogenic data on active bedrock fault scarps from Abruzzo, Italy

NASA Astrophysics Data System (ADS)

Gregory, Laura; Roberts, Gerald; Cowie, Patience; Wedmore, Luke; McCaffrey, Ken; Shanks, Richard; Zijerveld, Leo; Phillips, Richard

2017-04-01

In zones of distributed continental faulting, it is critical to understand how slip is partitioned onto brittle structures over both long-term millennial time scales and shorter-term individual earthquake cycles. Measuring earthquake slip histories on different timescales is challenging due to earthquake repeat-times being longer or similar to historical earthquake records, and a paucity of data on fault activity covering millennial to Quaternary scales in detail. Cosmogenic isotope analyses from bedrock fault scarps have the potential to bridge the gap, as these datasets track the exposure of fault planes due to earthquakes with millennial resolution. In this presentation, we present new 36Cl data combined with historical earthquake records to document orogen-wide changes in the distribution of seismicity on millennial timescales in Abruzzo, central Italy. Seismic activity due to extensional faulting was concentrated on the northwest side of the mountain range during the historical period, or since approximately the 14th century. Seismicity is more limited on the southwest side of Abruzzo during historical times. This pattern has led some to suggest that faults on the southwest side of Abruzzo are not active, however clear fault scarps cutting Holocene-aged slopes are well preserved across the whole of the orogen. These scarps preserve an excellent record of Late Pleistocene to Holocene earthquake activity, which can be quantified using cosmogenic isotopes that track the exposure of the bedrock fault scarps. 36Cl accumulates in the fault scarps as the plane is progressively exhumed by earthquakes and the concentration of 36Cl measured up the fault plane reflects the rate and patterns of slip. We utilise Bayesian modelling techniques to estimate slip histories based on the cosmogenic data. Each sampling site is carefully characterised using LiDAR and GPR to ensure that fault plane exposure is due to slip during earthquakes and not sediment transport processes. In this presentation we will focus on new data from faults located across-strike in Abruzzo. Many faults in Abruzzo demonstrate slip rate variability on millennial timescales, with relatively fast slip interspersed between quiescent periods. We show that heightened activity is co-located and spatially migrates across Abruzzo over time. We highlight the importance of understanding this dynamic fault behaviour of migrating seismic activity, and in particular how our research is relevant to the 2016 Amatrice-Vettore seismic sequence in central Italy.

Characteristics of earthquake-induced turbidites in Beppu Bay, southwest Japan

NASA Astrophysics Data System (ADS)

Yamada, K.; Takemura, K.; Kuwae, M.; Ikehara, K.; Yamamoto, M.

2015-12-01

Beppu Bay is located at the western end of the arc-bisecting dextral fault (Median Tectonic Line) associated with the northwestward subduction of the Philippine Sea Plate. According to Itoh et al. (1998) and Itoh et al. (2014), the process of formation of the bay was divided into two stages. The older stage (5 to 1.5 Ma) was dominated by a northward-inclined half-graben, while a pull-apart stress resulting from the right-stepping of the MTL developed during the younger stage (1.5 Ma to present in particular, 0.7 Ma to present), so seamless sediments were clearly preserved in the bay. Recently, Kuwae et al. (2012) revealed that the hemipelagic sediments accompanied with some event layers (18 major event layers (> 1 cm thick) and 55 minor event layers (< 1 cm thick)) were deposited. The core was well dated based on AMS 14C ages of 42 bivalves. In this study, we investigated the lithology of the event layers to understand how the layers were deposited. As a result, major event layers are classified into five types based on difference in the grain composition and facies: turbidites (type A-C), tephras (type D), and others (type E). Type A (4 layers) is thick event layers with a basal sand division, middle laminated silt division, and upper clay division. Relatively heavy particles, such as minerals, are concentrated in the basal division with clear erosion. Type B (7 layers) is similar to type A, but lack the basal division. Type C (5 layers) is almost the same as type B, but contains gypsum. Type D (2 layers) consists of a large amount of volcanic glass without bottom erosion. Type E (1 layer) is different from all other types and distinguishes by black color coarse particles and relatively high magnetic susceptibility. In particular, type A event layers are deposited in 334, 617, 1685, and 1893 cal. yrs BP using our age-depth model. The deposition age of an event layer corresponds to Keicho-Bungo historical earthquake occurred in 354 cal. yrs BP (Usami, 1996). The ages of other three layers are also not inconsistent with the ages of three fault events estimated by previous on-fault studies (Oita Prefecture, 2001; Chida et al., 2004). We thus concluded that the type A event layers were likely induced by earthquakes.

Identification of active fault using analysis of derivatives with vertical second based on gravity anomaly data (Case study: Seulimeum fault in Sumatera fault system)

NASA Astrophysics Data System (ADS)

Hududillah, Teuku Hafid; Simanjuntak, Andrean V. H.; Husni, Muhammad

2017-07-01

Gravity is a non-destructive geophysical technique that has numerous application in engineering and environmental field like locating a fault zone. The purpose of this study is to spot the Seulimeum fault system in Iejue, Aceh Besar (Indonesia) by using a gravity technique and correlate the result with geologic map and conjointly to grasp a trend pattern of fault system. An estimation of subsurface geological structure of Seulimeum fault has been done by using gravity field anomaly data. Gravity anomaly data which used in this study is from Topex that is processed up to Free Air Correction. The step in the Next data processing is applying Bouger correction and Terrin Correction to obtain complete Bouger anomaly that is topographically dependent. Subsurface modeling is done using the Gav2DC for windows software. The result showed a low residual gravity value at a north half compared to south a part of study space that indicated a pattern of fault zone. Gravity residual was successfully correlate with the geologic map that show the existence of the Seulimeum fault in this study space. The study of earthquake records can be used for differentiating the active and non active fault elements, this gives an indication that the delineated fault elements are active.

Database and Map of Quaternary Faults and Folds in Peru and its Offshore Region

USGS Publications Warehouse

Machare, Jose; Fenton, Clark H.; Machette, Michael N.; Lavenu, Alain; Costa, Carlos; Dart, Richard L.

2003-01-01

This publication consists of a main map of Quaternary faults and fiolds of Peru, a table of Quaternary fault data, a region inset map showing relative plate motion, and a second inset map of an enlarged area of interest in southern Peru. These maps and data compilation show evidence for activity of Quaternary faults and folds in Peru and its offshore regions of the Pacific Ocean. The maps show the locations, ages, and activity rates of major earthquake-related features such as faults and fault-related folds. These data are accompanied by text databases that describe these features and document current information on their activity in the Quaternary.

Losing sight of the future: Impaired semantic prospection following medial temporal lobe lesions

PubMed Central

Race, Elizabeth; Keane, Margaret M.; Verfaellie, Mieke

2012-01-01

The ability to imagine the future (prospection) relies on many of the same brain regions that support memory for the past. To date, scientific research has primarily focused on the neural substrates of episodic forms of prospection (mental simulation of spatiotemporally specific future events) whereas little is known about the neural substrates of semantic prospection (mental simulation of future nonpersonal facts). Of particular interest is the role of the medial temporal lobes, and specifically the hippocampus. While the hippocampus has been proposed to play a key role in episodic prospection, recent evidence suggests that it may not play a similar role in semantic prospection. To examine this possibility, amnesic patients with medial temporal lobe (MTL) lesions were asked to imagine future issues occurring in the public domain. The results showed that patients could list general semantic facts about the future, but when probed to elaborate, patients produced impoverished descriptions that lacked semantic detail. This impairment occurred despite intact performance on standard neuropsychological tests of semantic processing, and did not simply reflect deficits in narrative construction. The performance of a patient with damage limited to the hippocampus was similar to that of the remaining MTL patients and amnesic patients’ impaired elaboration of the semantic future correlated with their impaired elaboration of the semantic past. Together, these results provide novel evidence from MTL amnesia that memory and prospection are linked in the semantic domain and reveal that the medial temporal lobes play a critical role in the construction of detailed, multi-element semantic simulations. PMID:23197413

Network reconfiguration and working memory impairment in mesial temporal lobe epilepsy.

PubMed

Campo, Pablo; Garrido, Marta I; Moran, Rosalyn J; García-Morales, Irene; Poch, Claudia; Toledano, Rafael; Gil-Nagel, Antonio; Dolan, Raymond J; Friston, Karl J

2013-05-15

Mesial temporal lobe epilepsy (mTLE) is the most prevalent form of focal epilepsy, and hippocampal sclerosis (HS) is considered the most frequent associated pathological finding. Recent connectivity studies have shown that abnormalities, either structural or functional, are not confined to the affected hippocampus, but can be found in other connected structures within the same hemisphere, or even in the contralesional hemisphere. Despite the role of hippocampus in memory functions, most of these studies have explored network properties at resting state, and in some cases compared connectivity values with neuropsychological memory scores. Here, we measured magnetoencephalographic responses during verbal working memory (WM) encoding in left mTLE patients and controls, and compared their effective connectivity within a frontotemporal network using dynamic causal modelling. Bayesian model comparison indicated that the best model included bilateral, forward and backward connections, linking inferior temporal cortex (ITC), inferior frontal cortex (IFC), and the medial temporal lobe (MTL). Test for differences in effective connectivity revealed that patients exhibited decreased ipsilesional MTL-ITC backward connectivity, and increased bidirectional IFC-MTL connectivity in the contralesional hemisphere. Critically, a negative correlation was observed between these changes in patients, with decreases in ipsilesional coupling among temporal sources associated with increases contralesional frontotemporal interactions. Furthermore, contralesional frontotemporal interactions were inversely related to task performance and level of education. The results demonstrate that unilateral sclerosis induced local and remote changes in the dynamic organization of a distributed network supporting verbal WM. Crucially, pre-(peri) morbid factors (educational level) were reflected in both cognitive performance and (putative) compensatory changes in physiological coupling. Copyright © 2013 Elsevier Inc. All rights reserved.

Failure to Acquire New Semantic Knowledge in Patients With Large Medial Temporal Lobe Lesions

PubMed Central

Bayley, Peter J.; Squire, Larry R.

2009-01-01

We examined new semantic learning in two profoundly amnesic patients (E.P. and G.P.) whose lesions involve virtually the entire medial temporal lobe (MTL) bilaterally. The patients were given five tests of semantic knowledge for information that could only have been acquired after the onset of their amnesia in 1992 and 1987, respectively. Age-matched and education-matched controls (n = 8) were also tested. On tests of recall, E.P. and G.P. each scored 10% correct on a test of 20 easy factual questions (controls = 90%), 2% and 4% correct on 55 questions about news events (controls = 85%), and 0% and 4% correct on a test of 24 famous faces. On three tests of recognition memory for this same material, the patients scored at chance levels. Similarly, the patients were unable to judge whether persons who had been famous for many decades were still living or had died during the past 10 years (E.P. = 53%; G.P. = 50%; controls = 73%; chance = 50%). Lastly, neither patient E.P. nor patient G.P. could draw an accurate floor plan of his current residence, despite having lived there for 10 years and 1 year, respectively. The results demonstrate that the capacity for new semantic learning can be absent, or nearly absent, when there is virtually complete damage to the MTL bilaterally. Accordingly, the results raise the possibility that the acquisition of conscious (declarative) knowledge about the world cannot be supported by structures outside the MTL, even with extended exposure. PMID:15523609

Zen meditation, Length of Telomeres, and the Role of Experiential Avoidance and Compassion.

PubMed

Alda, Marta; Puebla-Guedea, Marta; Rodero, Baltasar; Demarzo, Marcelo; Montero-Marin, Jesus; Roca, Miquel; Garcia-Campayo, Javier

Mindfulness refers to an awareness that emerges by intentionally focusing on the present experience in a nonjudgmental or evaluative manner. Evidence regarding its efficacy has been increasing exponentially, and recent research suggests that the practice of meditation is associated with longer leukocyte telomere length. However, the psychological mechanisms underlying this potential relationship are unknown. We examined the telomere lengths of a group of 20 Zen meditation experts and another 20 healthy matched comparison participants who had not previously meditated. We also measured multiple psychological variables related to meditation practice. Genomic DNA was extracted for telomere measurement using a Life Length proprietary program. High-throughput quantitative fluorescence in situ hybridization (HT-Q-FISH) was used to measure the telomere length distribution and the median telomere length (MTL). The meditators group had a longer MTL ( p  = 0.005) and a lower percentage of short telomeres in individual cells ( p  = 0.007) than those in the comparison group. To determine which of the psychological variables contributed more to telomere maintenance, two regression analyses were conducted. In the first model, which applied to the MTL, the following three factors were significant: age, absence of experiential avoidance, and Common Humanity subscale of the Self Compassion Scale. Similarly, in the model that examined the percentage of short telomeres, the same factors were significant: age, absence of experiential avoidance, and Common Humanity subscale of the Self Compassion Scale. Although limited by a small sample size, these results suggest that the absence of experiential avoidance of negative emotions and thoughts is integral to the connection between meditation and telomeres.

Mid-term development of hamstring tendon length and velocity after distal femoral extension osteotomy in children with bilateral cerebral palsy: a retrospective cohort study.

PubMed

Salami, Firooz; Wagner, Julia; van Drongelen, Stefan; Klotz, Matthias C M; Dreher, Thomas; Wolf, Sebastian I; Niklasch, Mirjam

2018-03-14

Flexed knee gait can be treated with distal femoral extension osteotomy (DFEO) and additional patellar tendon advancement (PTA) in children with cerebral palsy (CP). This study assesses changes in hamstring muscle tendon length (MTL) and velocity after DFEO (+PTA). Nineteen children (mean age 13y [standard deviation 3y] at surgery) with CP and flexed knee gait who were treated with DFEO (15 limbs) or DFEO+PTA (10 limbs) were retrospectively included in this study. Gait analyses were performed preoperatively (E0), 1 year postoperatively (E1), and for 10 limbs additionally 2 to 5 years postoperatively (E2). Hamstring MTL and velocities were assessed at all examination dates using OpenSim. Hamstring MTL and velocity did not change significantly over time. From E0 to E1, knee flexion in stance improved for both DFEO and DFEO+PTA (p<0.05), knee flexion in swing only improved after DFEO+PTA (p<0.05). The improved knee flexion in stance and swing was maintained at E2. DFEO led to a significant improvement in knee kinematics at E1 which was maintained at E2. DFEO seems to prevent recurrent hamstring tightness but does not lead to lengthened or fastened hamstrings. Distal femoral extension osteotomy (DFEO) does not change hamstring muscle tendon length. DFEO does not change hamstring lengthening velocity. DFEO leads to a significant improvement in knee kinematics. Changes in knee kinematics after DFEO can be maintained at mid-term. DFEO seems to prevent recurrent hamstring tightness. © 2018 Mac Keith Press.

Altered chemical metabolites in the amygdala-hippocampus region contribute to autistic symptoms of autism spectrum disorders.

PubMed

Endo, Taro; Shioiri, Toshiki; Kitamura, Hideaki; Kimura, Teruo; Endo, Sumio; Masuzawa, Naio; Someya, Toshiyuki

2007-11-01

Although several previous studies have been conducted, the neural basis of autism spectrum disorder (ASD) is poorly understood. The objective of the present study was to determine whether individuals with ASD have altered brain chemical metabolites and whether such alterations are related to their autistic symptoms. N-acetylaspartate (NAA)/creatine (Cr) and choline/Cr ratios in the right medial temporal lobe (MTL), medial prefrontal cortex, and cerebellar vermis were measured in 38 individuals with ASD (mean age = 12.9 years), including 12 with autism, 15 with Asperger's Disorder, and 11 with pervasive developmental disorder not otherwise specified (PDD-NOS), and 16 matched healthy control subjects (mean age = 11.5 years) with proton magnetic resonance spectroscopy. Autistic symptoms were assessed by the Childhood Autistic Rating Scale-Tokyo Version. There was a significant group difference for NAA/Cr ratio in the right MTL between the autism, Asperger's Disorder, PDD-NOS, and control groups (p < .001), and the autism group had a significantly lower NAA/Cr ratio compared with the PDD-NOS (p < .001) and control (p < .001) groups. In the ASD group, there was a significant negative correlation between NAA/Cr ratio in the right MTL and their Childhood Autistic Rating Scale-Tokyo Version total scores (r = -.44, p = .01) and subscales of emotional response (r = -.38, p = .02) and listening response (r = -.54, p = .001). The results of the present study suggest that subjects with ASD have abnormalities of neural integrity in the amygdala-hippocampus region that are related to their severity and social impairments.

A Unified Mathematical Framework for Coding Time, Space, and Sequences in the Hippocampal Region

PubMed Central

MacDonald, Christopher J.; Tiganj, Zoran; Shankar, Karthik H.; Du, Qian; Hasselmo, Michael E.; Eichenbaum, Howard

2014-01-01

The medial temporal lobe (MTL) is believed to support episodic memory, vivid recollection of a specific event situated in a particular place at a particular time. There is ample neurophysiological evidence that the MTL computes location in allocentric space and more recent evidence that the MTL also codes for time. Space and time represent a similar computational challenge; both are variables that cannot be simply calculated from the immediately available sensory information. We introduce a simple mathematical framework that computes functions of both spatial location and time as special cases of a more general computation. In this framework, experience unfolding in time is encoded via a set of leaky integrators. These leaky integrators encode the Laplace transform of their input. The information contained in the transform can be recovered using an approximation to the inverse Laplace transform. In the temporal domain, the resulting representation reconstructs the temporal history. By integrating movements, the equations give rise to a representation of the path taken to arrive at the present location. By modulating the transform with information about allocentric velocity, the equations code for position of a landmark. Simulated cells show a close correspondence to neurons observed in various regions for all three cases. In the temporal domain, novel secondary analyses of hippocampal time cells verified several qualitative predictions of the model. An integrated representation of spatiotemporal context can be computed by taking conjunctions of these elemental inputs, leading to a correspondence with conjunctive neural representations observed in dorsal CA1. PMID:24672015

Assessment of Alzheimer's disease risk with functional magnetic resonance imaging: an arterial spin labeling study.

PubMed

Bangen, Katherine J; Restom, Khaled; Liu, Thomas T; Wierenga, Christina E; Jak, Amy J; Salmon, David P; Bondi, Mark W

2012-01-01

Functional magnetic resonance imaging (fMRI) of older adults at risk for Alzheimer's disease (AD) by virtue of their cognitive (i.e., mild cognitive impairment [MCI]) and/or genetic (i.e., apolipoprotein E [APOE] ε4 allele) status demonstrate divergent brain response patterns during memory encoding across studies. Using arterial spin labeling MRI, we examined the influence of AD risk on resting cerebral blood flow (CBF) as well as the CBF and blood oxygenation level dependent (BOLD) signal response to memory encoding in the medial temporal lobes (MTL) in 45 older adults (29 cognitively normal [14 APOE ε4 carriers and 15 noncarriers]; 16 MCI [8 APOE ε4 carriers, 8 noncarriers]). Risk groups were comparable in terms of mean age, years of education, gender distribution, and vascular risk burden. Individuals at genetic risk for AD by virtue of the APOE ε4 allele demonstrated increased MTL resting state CBF relative to ε4 noncarriers, whereas individuals characterized as MCI showed decreased MTL resting state CBF relative to their cognitively normal peers. For percent change CBF, there was a trend toward a cognitive status by genotype interaction. In the cognitively normal group, there was no difference in percent change CBF based on APOE genotype. In contrast, in the MCI group, APOE ε4 carriers demonstrated significantly greater percent change in CBF relative to ε4 noncarriers. No group differences were found for BOLD response. Findings suggest that abnormal resting state CBF and CBF response to memory encoding may be early indicators of brain dysfunction in individuals at risk for developing AD.

Amphetamine sensitisation and memory in healthy human volunteers: a functional magnetic resonance imaging study.

PubMed

O'Daly, Owen G; Joyce, Daniel; Tracy, Derek K; Stephan, Klaas E; Murray, Robin M; Shergill, Sukhwinder

2014-09-01

Amphetamine sensitisation (AS) is an established animal model of the hypersensitivity to psychostimulants seen in patients with schizophrenia. AS also models the dysregulation of mesolimbic dopamine signalling which has been implicated in the development of psychotic symptoms. Recent data suggest that the enhanced excitability of mesolimbic dopamine neurons in AS is driven by a hyperactivity of hippocampal (subiculum) neurons, consistent with a strong association between hippocampal dysfunction and schizophrenia. While AS can be modelled in human volunteers, its functional consequences on dopaminoceptive brain regions (i.e. striatum and hippocampus) remains unclear. Here we describe the effects of a sensitising dosage pattern of dextroamphetamine on the neural correlates of motor sequence learning in healthy volunteers, within a randomised, double-blind, parallel-groups design. Behaviourally, sensitisation was characterised by enhanced subjective responses to amphetamine but did not change performance (i.e. learning rate) during an explicit sequence learning task. In contrast, functional magnetic resonance imaging (fMRI) measurements showed that repeated intermittent amphetamine exposure was associated with increased blood-oxygen-level dependent (BOLD) signal within the medial temporal lobe (MTL) (subiculum/entorhinal cortex) and midbrain, in the vicinity of the substantia nigra/ventral tegmental area (SN/VTA) during sequence encoding. Importantly, MTL hyperactivity correlated with the sensitisation of amphetamine-induced attentiveness. The MTL-midbrain hyperactivity reported here mirrors observations in sensitised rodents and is consistent with contemporary models of schizophrenia and behavioural sensitisation. These findings of meso-hippocampal hyperactivity during AS thus link pathophysiological concepts of dopamine dysregulation to cognitive models of psychosis. © The Author(s) 2014.

Active tectonic deformation of the western Indian plate boundary: A case study from the Chaman Fault System

NASA Astrophysics Data System (ADS)

Crupa, Wanda E.; Khan, Shuhab D.; Huang, Jingqiu; Khan, Abdul S.; Kasi, Aimal

2017-10-01

Collision of the Eurasian and Indian plates has resulted in two spatially offset subduction zones, the Makran subduction zone to the south and the Himalayan convergent margin to the north. These zones are linked by a system of left-lateral strike-slip faults known as the Chaman Fault System, ∼1200 km, which spans along western Pakistan. Although this is one of the greatest strike-slip faults, yet temporal and spatial variation in displacement has not been adequately defined along this fault system. This study conducted geomorphic and geodetic investigations along the Chaman Fault in a search for evidence of spatial variations in motion. Four study areas were selected over the span of the Chaman Fault: (1) Tarnak-Rud area over the Tarnak-Rud valley, (2) Spinatizha area over the Spinatizha Mountain Range, (3) Nushki area over the Nushki basin, and (4) Kharan area over the northern tip of the Central Makran Mountains. Remote sensing data allowed for in depth mapping of different components and faults within the Kohjak group. Wind and water gap pairs along with offset rivers were identified using high-resolution imagery and digital-elevation models to show displacement for the four study areas. The mountain-front-sinuosity ratio, valley height-to-width-ratio, and the stream-length-gradient index were calculated and used to determine the relative tectonic activity of each area. These geomorphic indices suggest that the Kharan area is the most active and the Tarnak-Rud area is the least active. GPS data were processed into a stable Indian plate reference frame and analyzed. Fault parallel velocity versus fault normal distance yielded a ∼8-10 mm/yr displacement rate along the Chaman Fault just north of the Spinatizha area. InSAR data were also integrated to assess displacement rates along the fault system. Geodetic data support that ultra-slow earthquakes similar to those that strike along other major strike-slip faults, such as the San Andreas Fault System, are possible along the northern segments of the Chaman Fault zone. Geomorphic data suggest that the Chaman Fault along southern part is not very active now but may have gone through high tectonic activity in the past.

Towards a Fault-based SHA in the Southern Upper Rhine Graben

NASA Astrophysics Data System (ADS)

Baize, Stéphane; Reicherter, Klaus; Thomas, Jessica; Chartier, Thomas; Cushing, Edward Marc

2016-04-01

A brief overview at a seismic map of the Upper Rhine Graben area (say between Strasbourg and Basel) reveals that the region is seismically active. The area has been hit recently by shallow and moderate quakes but, historically, strong quakes damaged and devastated populated zones. Several authors previously suggested, through preliminary geomorphological and geophysical studies, that active faults could be traced along the eastern margin of the graben. Thus, fault-based PSHA (probabilistic seismic hazard assessment) studies should be developed. Nevertheless, most of the input data in fault-based PSHA models are highly uncertain, based upon sparse or hypothetical data. Geophysical and geological data document the presence of post-Tertiary westward dipping faults in the area. However, our first investigations suggest that the available surface fault map do not provide a reliable document of Quaternary fault traces. Slip rate values that can be currently used in fault-PSHA models are based on regional stratigraphic data, but these include neither detailed datings nor clear base surface contours. Several hints on fault activity do exist and we have now relevant tools and techniques to figure out the activity of the faults of concern. Our preliminary analyses suggest that the LiDAR topography can adequately image the fault segments and, thanks to detailed geomorphological analysis, these data allow tracking cumulative fault offsets. Because the fault models can therefore be considered highly uncertain, our coming project for the next 3 years is to acquire and analyze these accurate topographical data, to trace the active faults and to determine slip rates through relevant features dating. Eventually, we plan to find a key site to perform a paleoseismological trench because this approach has been proved to be worth in the Graben, both to the North (Wörms and Strasbourg) and to the South (Basel). This would be done in order to definitely prove whether the faults ruptured the ground surface during the Quaternary, and in order to determine key fault parameters such as magnitude and age of large events.

Seismicity and Seismotectonic Properties of The Sultandağı Fault Zone (Afyonkarahisar-Konya): Western Anatolia,Turkey

NASA Astrophysics Data System (ADS)

Kalafat, D.; Gunes, Y.; Kekovali, K.; Kara, M.; Gorgun, E.

2017-12-01

n this study we investigated seismicity and source characteristics of the Sultandağı Fault Zone (SFZ). As known Western Anatolia is one of the most important seismically active region in Turkey. The relative movement of the African-Arabian plates, it causes the Anatolian Plate to movement to the west-Southwest direction 2.5 cm per year and this result provides N-S direction with extensional regime in the recent tectonic. In this study, especially with the assessment of seismic activity occurring in Afyon and around between 200-2002 years, we have been evaluated to date with seismic activity as well as fault mechanism solution. We analyzed recent seismicity and distribution of earthquakes in this region. In the last century, 3 important earthquakes occurred in the Sultandağı Fault zone (Afyon-Akşehir Graben), this result shown it was seismic active and broken fault segments caused stress balance in the region and it caused to occur with short intervals of earthquakes in 2000 and 2002, triggering each other. The scope of this tudy, we installed new BB stations in the region and we have been done of the fault plane solutions for important earthquakes. The focal mechanisms clearly exhibit the activation of a NE-SW trending normal faulting system along the SFZ region. The results of stress analysis showed that the effective current tectonic evolution of normal faulting in this region. This study is supported by Bogazici University Research Projects Commission under SRP/BAP project No. 12280. Key Words: Sultandağı fault zone, normal faulting, seismicity, fault mechanism

Central Japan's Atera Active Fault's Wide-Fractured Zone: An Examination of the Structure and In-situ Crustal Stress

NASA Astrophysics Data System (ADS)

Ikeda, R.; Omura, K.; Matsuda, T.; Mizuochi, Y.; Uehara, D.; Chiba, A.; Kikuchi, A.; Yamamoto, T.

2001-12-01

In-situ downhole measurements and coring within and around an active fault zone are needed to better understand the structure and material properties of fault rocks as well as the physical state of active faults and intra-plate crust. Particularly, the relationship between the stress concentration state and the heterogeneous strength of an earthquake fault zone is important to estimate earthquake occurrence mechanisms which correspond to the prediction of an earthquake. It is necessary to compare some active faults in different conditions of the chrysalis stage and their relation to subsequent earthquake occurrence. To better understand such conditions, "Active Fault Zone Drilling Project" has been conducted in the central part of Japan by the National Research Institute for Earth Science and Disaster Prevention. The Nojima fault which appeared on the surface by the 1995 Great Kobe earthquake (M=7.2) and the Neodani fault created by the 1981 Nobi earthquake, the greatest inland earthquake M=8.0 in Japan, have been drilled through the fault fracture zones. During these past four years, a similar experiment and research at the Atera fault, of which some parts seem to have been dislocated by the 1586 Tensyo earthquake, has been undertaken. The features of the Atera fault are as follows: (1) total length is about 70 km, (2) general trend is NW45_Kwith a left-lateral strike slip, (3) slip rate is estimated as 3-5 m/1000 yrs. and the average recurrence time as 1700 yrs., (4) seismicity is very low at present, and (5) lithologies around the fault are basically granitic rocks and rhyolite. We have conducted integrated investigations by surface geophysical survey and drilling around the Atera fault. Six boreholes have been drilled from the depth of 400 m to 630 m. Four of these boreholes are located on a line crossing the fracture zone of the Atera fault. Resistivity and gravity structures inferred from surface geophysical surveys were compared with the physical properties determined from the borehole logging data and core samples. These results were also compared with in situ stress data by the hydraulic fracturing stress measurements in the boreholes. We obtained characteristic states on crustal stress and strength of the fault from these investigations. Our findings are as follows: (1) The fracture zone around the Atera fault shows a very wide and complex fracture structure, from approximately 1 km to 4 km wide. The average slip rate was estimated to be 5.3 m /1000 yrs. by the distribution of basalt in age of 1.5 Ma by radioactive dating. We inferred that the Atera fault has been repeatedly active in recent geologic time; however, it is in a very weak state at present. (2) The stress magnitude decreases in the area closer to the center of the fracture zone. Furthermore the orientation of the maximum horizontal compressive stress was almost in a North-South direction, just reverse of the fault moving direction. These are important results to evaluate fault activity. We argue that the stress state observed in these sites exists only when the faults are quite "weak," and thus does not reach to a critical level of fault activation in the present situation.

Preservation of amorphous ultrafine material: A proposed proxy for slip during recent earthquakes on active faults

PubMed Central

Hirono, Tetsuro; Asayama, Satoru; Kaneki, Shunya; Ito, Akihiro

2016-01-01

The criteria for designating an “Active Fault” not only are important for understanding regional tectonics, but also are a paramount issue for assessing the earthquake risk of faults that are near important structures such as nuclear power plants. Here we propose a proxy, based on the preservation of amorphous ultrafine particles, to assess fault activity within the last millennium. X-ray diffraction data and electron microscope observations of samples from an active fault demonstrated the preservation of large amounts of amorphous ultrafine particles in two slip zones that last ruptured in 1596 and 1999, respectively. A chemical kinetic evaluation of the dissolution process indicated that such particles could survive for centuries, which is consistent with the observations. Thus, preservation of amorphous ultrafine particles in a fault may be valuable for assessing the fault’s latest activity, aiding efforts to evaluate faults that may damage critical facilities in tectonically active zones. PMID:27827413

Preliminary atlas of active shallow tectonic deformation in the Puget Lowland, Washington

USGS Publications Warehouse

Barnett, Elizabeth A.; Haugerud, Ralph A.; Sherrod, Brian L.; Weaver, Craig S.; Pratt, Thomas L.; Blakely, Richard J.

2010-01-01

This atlas presents an up-to-date map compilation of the geological and geophysical observations that underpin interpretations of active, surface-deforming faults in the Puget Lowland, Washington. Shallow lowland faults are mapped where observations of deformation from paleoseismic, seismic-reflection, and potential-field investigations converge. Together, results from these studies strengthen the identification and characterization of regional faults and show that as many as a dozen shallow faults have been active during the Holocene. The suite of maps presented in our atlas identifies sites that have evidence of deformation attributed to these shallow faults. For example, the paleoseismic-investigations map shows where coseismic surface rupture and deformation produced geomorphic scarps and deformed shorelines. Other maps compile results of seismic-reflection and potential-field studies that demonstrate evidence of deformation along suspected fault structures in the subsurface. Summary maps show the fault traces derived from, and draped over, the datasets presented in the preceding maps. Overall, the atlas provides map users with a visual overview of the observations and interpretations that support the existence of active, shallow faults beneath the densely populated Puget Lowland.

A remote sensing study of active folding and faulting in southern Kerman province, S.E. Iran

NASA Astrophysics Data System (ADS)

Walker, Richard Thomas

2006-04-01

Geomorphological observations reveal a major oblique fold-and-thrust belt in Kerman province, S.E. Iran. The active faults appear to link the Sabzevaran right-lateral strike-slip fault in southeast Iran to other strike-slip faults within the interior of the country and may provide the means of distributing right-lateral shear between the Zagros and Makran mountains over a wider region of central Iran. The Rafsanjan fault is manifest at the Earth's surface as right-lateral strike-slip fault scarps and folding in alluvial sediments. Height changes across the anticlines, and widespread incision of rivers, are likely to result from hanging-wall uplift above thrust faults at depth. Scarps in recent alluvium along the northern margins of the folds suggest that the thrusts reach the surface and are active at the present-day. The observations from Rafsanjan are used to identify similar late Quaternary faulting elsewhere in Kerman province near the towns of Mahan and Rayen. No instrumentally recorded destructive earthquakes have occurred in the study region and only one historical earthquake (Lalehzar, 1923) is recorded. In addition GPS studies show that present-day rates of deformation are low. However, fault structures in southern Kerman province do appear to be active in the late Quaternary and may be capable of producing destructive earthquakes in the future. This study shows how widely available remote sensing data can be used to provide information on the distribution of active faulting across large areas of deformation.

Response of deformation patterns to reorganizations of the southern San Andreas fault system since ca. 1.5 Ma

NASA Astrophysics Data System (ADS)

Cooke, M. L.; Fattaruso, L.; Dorsey, R. J.; Housen, B. A.

2015-12-01

Between ~1.5 and 1.1 Ma, the southern San Andreas fault system underwent a major reorganization that included initiation of the San Jacinto fault and termination of slip on the extensional West Salton detachment fault. The southern San Andreas fault itself has also evolved since this time, with several shifts in activity among fault strands within San Gorgonio Pass. We use three-dimensional mechanical Boundary Element Method models to investigate the impact of these changes to the fault network on deformation patterns. A series of snapshot models of the succession of active fault geometries explore the role of fault interaction and tectonic loading in abandonment of the West Salton detachment fault, initiation of the San Jacinto fault, and shifts in activity of the San Andreas fault. Interpreted changes to uplift patterns are well matched by model results. These results support the idea that growth of the San Jacinto fault led to increased uplift rates in the San Gabriel Mountains and decreased uplift rates in the San Bernardino Mountains. Comparison of model results for vertical axis rotation to data from paleomagnetic studies reveals a good match to local rotation patterns in the Mecca Hills and Borrego Badlands. We explore the mechanical efficiency at each step in the evolution, and find an overall trend toward increased efficiency through time. Strain energy density patterns are used to identify regions of off-fault deformation and potential incipient faulting. These patterns support the notion of north-to-south propagation of the San Jacinto fault during its initiation. The results of the present-day model are compared with microseismicity focal mechanisms to provide additional insight into the patterns of off-fault deformation within the southern San Andreas fault system.

GeoBioScience: Red Wood Ants as Bioindicators for Active Tectonic Fault Systems in the West Eifel (Germany)

PubMed Central

Berberich, Gabriele; Schreiber, Ulrich

2013-01-01

Simple Summary In a 1.140 km² study area of the volcanic West Eifel, approx. 3,000 Red Wood Ant (RWA; Formica rufa-group) mounds had been identified and correlated with tectonically active gas-permeable faults, mostly strike-slip faults. Linear alignment of RWA mounds and soil gas anomalies distinctly indicate the course of these faults, while clusters of mounds indicate crosscut zones of fault systems, which can be correlated with voids caused by crustal block rotation. This demonstrates that RWA are bioindicators for identifying active fault systems and useful where information on the active regime is incomplete or the resolution by technical means is insufficient. Abstract In a 1.140 km² study area of the volcanic West Eifel, a comprehensive investigation established the correlation between red wood ant mound (RWA; Formica rufa-group) sites and active tectonic faults. The current stress field with a NW-SE-trending main stress direction opens pathways for geogenic gases and potential magmas following the same orientation. At the same time, Variscan and Mesozoic fault zones are reactivated. The results showed linear alignments and clusters of approx. 3,000 RWA mounds. While linear mound distribution correlate with strike-slip fault systems documented by quartz and ore veins and fault planes with slickensides, the clusters represent crosscut zones of dominant fault systems. Latter can be correlated with voids caused by crustal block rotation. Gas analyses from soil air, mineral springs and mofettes (CO2, Helium, Radon and H2S) reveal limiting concentrations for the spatial distribution of mounds and colonization. Striking is further the almost complete absence of RWA mounds in the core area of the Quaternary volcanic field. A possible cause can be found in occasionally occurring H2S in the fault systems, which is toxic at miniscule concentrations to the ants. Viewed overall, there is a strong relationship between RWA mounds and active tectonics in the West Eifel. PMID:26487413

Structural control on the CO2 release west of Mt. Epomeo resurgent block (Ischia, Italy)

NASA Astrophysics Data System (ADS)

de Vita, S.; Marotta, E.; Ventura, G.; Chiodini, G.

2003-04-01

Volcanism at Ischia started more than 150 ka B.P. and continued until the last eruption occurred in 1302 A.D. Ischia is dominated by the caldera forming eruption of Mt. Epomeo Green Tuff (55 ka), which was followed by block resurgence inside the caldera from 33 ka B.P. Resurgence influenced the volcanic activity determining the conditions for magma ascent mainly along the eastern edge of the resurgent block. The resurgent area has a poligonal shape resulting from reactivation of regional faults and by activation of faults related to volcanotectonism. The western sector is bordered by inward dipping, high angle strike-slip/reverse faults testifying a compressional stress regime in this area. These features are cut by late outward dipping normal faults due to gravitational stress. The activity of the volcanic system is testified by seismicity and thermal manifestations. Fumarolic activity concentrates along the faults that borders westward the Mt. Epomeo resurgent block, where the Green Tuff overlies fractured lavas. The structural data show that, outside the most active degassing zone, fractures show a NNW-SSE strike and dip toward Mt. Epomeo. These fractures delimit the northern sector of Mt. Epomeo and show strike and dip consistent with the inward dipping reverse faults. Inside the degassing area fractures show a NW-SE strike and dip outward Mt. Epomeo. These gravity-related faults cut the lavas where the hydrothermal circulation is active. The dip direction of the NW-SE striking fractures within the degassing zone is not consistent with that of the strike-slip/reverse faults (i.e. towards NE) but agrees well with that of the gravity-induced faults (dip direction towards SW). Inside the degassing zone, NW-SE striking faults with lengths not exceeding the hydrothermalized extension occur. This arrangement indicate that the syn-resurgence faults act as permeability barriers, whereas the youngest faults act as the main fluid pathway.

Deep heterogeneous structure of active faults in the Kinki region, southwest Japan: Inversion analysis of coda envelopes

NASA Astrophysics Data System (ADS)

Nishigami, K.

2006-12-01

It is essential to estimate the deep structure of active faults related to the earthquake rupture process as well as the crustal structure related to the propagation of seismic waves, in order to improve the accuracy of estimating strong ground motion caused by future large inland earthquakes. In the Kinki region, southwest Japan, there are several active fault zones near large cities such as Osaka and Kyoto, and the evaluation of realistic strong ground motion is an important subject. We have been carrying out the Special Project for Earthquake Disaster Mitigation in Urban Areas, in the Kinki region for these purposes. In this presentation we will show the result of estimating the fault structure model of the Biwako-seigan, Hanaore, and Arima- Takatsuki fault zones. We estimated a 3-D distribution of relative scattering coefficients in the Kinki region, also in the vicinity of each active fault zone, by inversion of coda envelopes from local earthquakes. We analyzed 758 seismograms from 52 events which occurred in 2003, recorded at 50 stations of Kyoto Univ., Hi- net, and JMA. The preliminary result shows that active fault zones can be imaged as higher scattering than the surroundings. Based on previous studies of scattering properties in the crust, we consider that the relatively weaker scattering (namely more homogeneous) part on the fault plane may act as an asperity during future large earthquakes, and also that the part with relatively stronger scattering (namely more heterogeneous part) may become an initiation point of rupture. We are also studying the detailed distribution of microearthquakes, b-values, and velocity anomalies along these active fault zones. Combining these results, we will construct a possible fault model for each of the active fault zones. This study is sponsored by the Special Project for Earthquake Disaster Mitigation in Urban Areas from the Ministry of Education, Culture, Sports, Science and Technology of Japan.

Tectonics earthquake distribution pattern analysis based focal mechanisms (Case study Sulawesi Island, 1993–2012)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ismullah M, Muh. Fawzy, E-mail: mallaniung@gmail.com; Lantu,; Aswad, Sabrianto

Indonesia is the meeting zone between three world main plates: Eurasian Plate, Pacific Plate, and Indo – Australia Plate. Therefore, Indonesia has a high seismicity degree. Sulawesi is one of whose high seismicity level. The earthquake centre lies in fault zone so the earthquake data gives tectonic visualization in a certain place. This research purpose is to identify Sulawesi tectonic model by using earthquake data from 1993 to 2012. Data used in this research is the earthquake data which consist of: the origin time, the epicenter coordinate, the depth, the magnitude and the fault parameter (strike, dip and slip). Themore » result of research shows that there are a lot of active structures as a reason of the earthquake in Sulawesi. The active structures are Walannae Fault, Lawanopo Fault, Matano Fault, Palu – Koro Fault, Batui Fault and Moluccas Sea Double Subduction. The focal mechanism also shows that Walannae Fault, Batui Fault and Moluccas Sea Double Subduction are kind of reverse fault. While Lawanopo Fault, Matano Fault and Palu – Koro Fault are kind of strike slip fault.« less

Response of deformation patterns to reorganization of the southern San Andreas fault system since ca. 1.5 Ma

NASA Astrophysics Data System (ADS)

Fattaruso, Laura A.; Cooke, Michele L.; Dorsey, Rebecca J.; Housen, Bernard A.

2016-12-01

Between 1.5 and 1.1 Ma, the southern San Andreas fault system underwent a major reorganization that included initiation of the San Jacinto fault zone and termination of slip on the extensional West Salton detachment fault. The southern San Andreas fault itself has also evolved since this time, with several shifts in activity among fault strands within San Gorgonio Pass. We use three-dimensional mechanical Boundary Element Method models to investigate the impact of these changes to the fault network on deformation patterns. A series of snapshot models of the succession of active fault geometries explore the role of fault interaction and tectonic loading in abandonment of the West Salton detachment fault, initiation of the San Jacinto fault zone, and shifts in activity of the San Andreas fault. Interpreted changes to uplift patterns are well matched by model results. These results support the idea that initiation and growth of the San Jacinto fault zone led to increased uplift rates in the San Gabriel Mountains and decreased uplift rates in the San Bernardino Mountains. Comparison of model results for vertical-axis rotation to data from paleomagnetic studies reveals a good match to local rotation patterns in the Mecca Hills and Borrego Badlands. We explore the mechanical efficiency at each step in the modeled fault evolution, and find an overall trend toward increased efficiency through time. Strain energy density patterns are used to identify regions of incipient faulting, and support the notion of north-to-south propagation of the San Jacinto fault during its initiation.

Active faulting in apparently stable peninsular India: Rift inversion and a Holocene-age great earthquake on the Tapti Fault

NASA Astrophysics Data System (ADS)

Copley, Alex; Mitra, Supriyo; Sloan, R. Alastair; Gaonkar, Sharad; Reynolds, Kirsty

2014-08-01

We present observations of active faulting within peninsular India, far from the surrounding plate boundaries. Offset alluvial fan surfaces indicate one or more magnitude 7.6-8.4 thrust-faulting earthquakes on the Tapti Fault (Maharashtra, western India) during the Holocene. The high ratio of fault displacement to length on the alluvial fan offsets implies high stress-drop faulting, as has been observed elsewhere in the peninsula. The along-strike extent of the fan offsets is similar to the thickness of the seismogenic layer, suggesting a roughly equidimensional fault rupture. The subsiding footwall of the fault is likely to have been responsible for altering the continental-scale drainage pattern in central India and creating the large west flowing catchment of the Tapti river. A preexisting sedimentary basin in the uplifting hanging wall implies that the Tapti Fault was active as a normal fault during the Mesozoic and has been reactivated as a thrust, highlighting the role of preexisting structures in determining the rheology and deformation of the lithosphere. The slip sense of faults and earthquakes in India suggests that deformation south of the Ganges foreland basin is driven by the compressive force transmitted between India and the Tibetan Plateau. The along-strike continuation of faulting to the east of the Holocene ruptures we have studied represents a significant seismic hazard in central India.

Active Fault Topography and Fault Outcrops in the Central Part of the Nukumi fault, the 1891 Nobi Earthquake Fault System, Central Japan

NASA Astrophysics Data System (ADS)

Sasaki, T.; Ueta, K.; Inoue, D.; Aoyagi, Y.; Yanagida, M.; Ichikawa, K.; Goto, N.

2010-12-01

It is important to evaluate the magnitude of earthquake caused by multiple active faults, taking into account the simultaneous effects. The simultaneity of adjacent active faults are often decided on the basis of geometric distances except for known these paleoseismic records. We have been studied the step area between the Nukumi fault and the Neodani fault, which appeared as consecutive ruptures in the 1891 Nobi earthquake, since 2009. The purpose of this study is to establish innovation in valuation technique of the simultaneity of adjacent active faults in addition to the paleoseismic record and the geometric distance. Geomorphological, geological and reconnaissance microearthquake surveys are concluded. The present work is intended to clarify the distribution of tectonic geomorphology along the Nukumi fault and the Neodani fault by high-resolution interpretations of airborne LiDAR DEM and aerial photograph, and the field survey of outcrops and location survey. The study area of this work is the southeastern Nukumi fault and the northwestern Neodani fault. We interpret DEM using shaded relief map and stereoscopic bird's-eye view made from 2m mesh DEM data which is obtained by airborne laser scanner of Kokusai Kogyo Co., Ltd. Aerial photographic survey is for confirmation of DEM interpretation using 1/16,000 scale photo. As a result of topographic survey, we found consecutive tectonic topography which is left lateral displacement of ridge and valley lines and reverse scarplets along the Nukumi fault and the Neodani fault . From Ogotani 2km southeastern of Nukumi pass which is located at the southeastern end of surface rupture along the Nukumi fault by previous study to Neooppa 9km southeastern of Nukumi pass, we can interpret left lateral topographies and small uphill-facing fault scarps on the terrace surface by detail DEM investigation. These topographies are unrecognized by aerial photographic survey because of heavy vegetation. We have found several new outcrops in this area where the surface ruptures of the 1891 Nobi earthquake have not been known. These outcrops have active fault which cut the layer of terrace deposit and slope deposit to the bottom of present soil layer in common. At the locality of Ogotani outcrop, the humic layer which age is from14th century to 15th century by 14C age dating is deformed by the active fault. The vertical displacement of the humic layer is 0.8-0.9m and the terrace deposit layer below the humic layer is ca. 1.3m. For this reason and the existence of fain grain deposit including AT tephra (28ka) in the footwall of the fault, this fault movement occurred more than once since the last glacial age. We conclude that the surface rupture of Nukumi fault in the 1891 Nobi earthquake is continuous to 9km southeast of Nukumi pass. In other words, these findings indicate that there is 10km parallel overlap zone between the surface rupture of the southeastern end of Nukumi fault and the northwestern end of Neodani fault.

The study of active tectonic based on hyperspectral remote sensing

NASA Astrophysics Data System (ADS)

Cui, J.; Zhang, S.; Zhang, J.; Shen, X.; Ding, R.; Xu, S.

2017-12-01

As of the latest technical methods, hyperspectral remote sensing technology has been widely used in each brach of the geosciences. However, it is still a blank for using the hyperspectral remote sensing to study the active structrure. Hyperspectral remote sensing, with high spectral resolution, continuous spectrum, continuous spatial data, low cost, etc, has great potentialities in the areas of stratum division and fault identification. Blind fault identification in plains and invisible fault discrimination in loess strata are the two hot problems in the current active fault research. Thus, the study of active fault based on the hyperspectral technology has great theoretical significance and practical value. Magnetic susceptibility (MS) records could reflect the rhythm alteration of the formation. Previous study shown that MS has correlation with spectral feature. In this study, the Emaokou section, located to the northwest of the town of Huairen, in Shanxi Province, has been chosen for invisible fault study. We collected data from the Emaokou section, including spectral data, hyperspectral image, MS data. MS models based on spectral features were established and applied to the UHD185 image for MS mapping. The results shown that MS map corresponded well to the loess sequences. It can recognize the stratum which can not identity by naked eyes. Invisible fault has been found in this section, which is useful for paleoearthquake analysis. The faults act as the conduit for migration of terrestrial gases, the fault zones, especially the structurally weak zones such as inrtersections or bends of fault, may has different material composition. We take Xiadian fault for study. Several samples cross-fault were collected and these samples were measured by ASD Field Spec 3 spectrometer. Spectral classification method has been used for spectral analysis, we found that the spectrum of the fault zone have four special spectral region(550-580nm, 600-700nm, 700-800nm and 800-900nm), which different with the spectrum of the none-fault zone. It could help us welly located the fault zone. The located result correspond well to the physical prospecting method result. The above study shown that Hypersepctral remote sensing technology provide a new method for active study.

Map showing recently active breaks along the San Andreas Fault between Pt. Delgada and Bolinas Bay, California

USGS Publications Warehouse

Brown, Robert D.; Wolfe, Edward W.

1970-01-01

This strip map is one of a series of maps showing recently active fault breaks along the San Andreas and other active faults in California. It is designed to inform persons who are concerned with land use near the fault of the location of those fault breaks that have moved recently. The lines on the map are lines of rupture and creep that can be identified by field evidence and that clearly affect the present surface of the land. Map users should keep in mind that these lines are intended primarily as guides to help locate the fault; the mapped lines are not necessarily shown with the precision demanded by some engineering or land utilization needs.

Geometry and active tectonics of the Los Osos-Hosgri Fault Intersection in Estero Bay, CA: Reconciling seismicity patterns with near-surface geology

NASA Astrophysics Data System (ADS)

Watt, J. T.; Hardebeck, J.; Johnson, S. Y.; Kluesner, J.

2016-12-01

Characterizing active structures within structurally complex fault intersections is essential for unraveling the deformational history and for assessing the importance of fault intersections in regional earthquake hazard assessments. We employ an integrative, multi-scale geophysical approach to describe the 3D geometry and active tectonics of the offshore Los Osos fault (LOF) in Estero Bay, California. The shallow structure of the LOF, as imaged with multibeam and high-resolution seismic-reflection data, reveals a complex west-diverging zone of active faulting that bends into and joins the Hosgri fault. The down-dip geometry of the LOF as revealed by gravity, magnetic, and industry multi-channel seismic data, is vertical to steeply-dipping and varies along strike. As the LOF extends offshore, it is characterized by SW-side-up motion on a series of W-NW trending, steeply SW-dipping reverse faults. The LOF bends to the north ( 23°) as it approaches the Hosgri fault and dips steeply to the NE along a magnetic basement block. Inversion of earthquake focal mechanisms within Estero Bay yields maximum compressive stress axes that are near-horizontal and trend approximately N15E. This trend is consistent with dextral strike-slip faulting along NW-SE trending structures such as the Hosgri fault and northern LOF, and oblique dip-slip motion along the W-NW trending section of the LOF. Notably, NW-SE trending structures illuminated by seismicity in Estero Bay coincide with, but also appear to cross-cut, LOF structures imaged in the near-surface. We suggest this apparent disconnect reflects ongoing fault reorganization at a dynamic and inherently unstable fault intersection, in which the seismicity reflects active deformation at depth that is not clearly expressed in the near-surface geology. Direct connectivity between the Hosgri and Los Osos faults suggests a combined earthquake rupture is possible; however, the geometrical complexity along the offshore LOF may limit the extent of rupture.

Characterization of Seismogenic Faults of Central Japan by Geophysical Survey and Drilling

NASA Astrophysics Data System (ADS)

Ikeda, R.; Omura, K.; Matsuda, T.

2004-12-01

Integrated investigations on seismogenic faults by geophysical survey and drilling are indispensable to better understand deep structure and physical properties of a fault fracture zone. In central Japan, three large active faults, Neodani, Atotsugawa and Atera faults, exist and are remarkable for research because of the potentiality of a scale of magnitude 7 to 8 class earthquake and the different characteristics of the seismogenic activities in these faults. Each individual fault shows its own characteristic features, which may reflect different stages in an earthquake cycle. High seismicity is concentrated with a clear lineation on and around the Atotsugawa fault, which is recognized as aftershocks from the latest event of the 1858 Hida earthquake (M=7.0). On the other hand, extremely low seismicity is found around the Atera fault, of which some parts seemed to be dislocated by the 1586 Tensyo earthquake (M=7.9). As an example of the results of study at the Atera fault, we obtained a wide variety of fault structures, composed materials, states of crustal stress and strengths of the fault from the geophysical survey (resistivity and gravity) and in-situ borehole experiments. Our findings are as follows: (1) The fracture zone around the Atera fault shows a very wide and complex fracture structure, from approximately 1 km to 4 km wide. (2) The average slip rate was estimated to be 5.3 m /1000 yr by the distribution of basalt in the age of 1.5 Ma as determined by radioactive dating. We inferred that the Atera fault has been repeatedly active in recent geologic time; however, it is in a very weak state at present. (3) Stress magnitude decreases in the area closer to the center of the fracture zone. These are important results to evaluate fault activity. Recent in-situ downhole measurements and coring through active faults have provided us with new insights into the physical properties of fault zones. In the vicinity of the epicenter of the 1995 Hyogo-ken Nanbu (Kobe) earthquake, we have conducted an integrated study by using 1,000 m to 1,800 m deep drilling wells. In particular, the Nojima-Hirabayashi borehole was drilled to a depth of 1,838 m and directly intersected the Nojima fault. Three possible fault strands were detected at depths of 1,140 m, 1,313 m and 1,800 m. Major results obtained from this study include the following: (1) Shear stress around the fault zone is very small, and the orientation of the maximum horizontal compression is perpendicular to the surface trace of faults. (2) From the results of a heat flow study, the lower cut-off depth of the aftershocks was estimated to be roughly 300 _E#8249;C. (3) Cores were classified into several types of fault rocks, and an asymmetric distribution pattern of these fault rocks in the fracture zones was identified. (4) Country rock is characterized by very low permeability and high strength. (5) Resistivity structure can be explained by a model of a fault extending to greater depths but with low resistivity. The integrated study by geophysical survey, drilling and core analyses, downhole measurements and long-term monitoring directly within these fault zones, provide us with characteristic features and dynamics of active faults.

Geometry and slip rates of active blind thrusts in a reactivated back-arc rift using shallow seismic imaging: Toyama basin, central Japan

NASA Astrophysics Data System (ADS)

Ishiyama, Tatsuya; Kato, Naoko; Sato, Hiroshi; Koshiya, Shin; Toda, Shigeru; Kobayashi, Kenta

2017-10-01

Active blind thrust faults, which can be a major seismic hazard in urbanized areas, are commonly difficult to image with seismic reflection surveys. To address these challenges in coastal plains, we collected about 8 km-long onshore high-resolution two-dimensional (2D) seismic reflection data using a dense array of 800 geophones across compressionally reactivated normal faults within a failed rift system located along the southwestern extension of the Toyama trough in the Sea of Japan. The processing of the seismic reflection data illuminated their detailed subsurface structures to depths of about 3 km. The interpreted depth-converted section, correlated with nearby Neogene stratigraphy, indicated the presence of and along-strike variation of previously unrecognized complex thrust-related structures composed of active fault-bend folds coupled with pairs of flexural slip faults within the forelimb and newly identified frontal active blind thrusts beneath the alluvial plain. In addition, growth strata and fold scarps that deform lower to upper Pleistocene units record the recent history of their structural growth and fault activity. This case shows that shallow seismic reflection imaging with densely spaced seismic recorders is a useful tool in defining locations, recent fault activity, and complex geometry of otherwise inaccessible active blind thrust faults.

Current state of active-fault monitoring in Taiwan

NASA Astrophysics Data System (ADS)

Hou, C.; Lin, C.; Chen, Y.; Liu, H.; Chen, C.; Lin, Y.; Chen, C.

2008-12-01

The earthquake is one of the major hazard sources in Taiwan where an arc-continent collision is on-going. For the purpose of seismic hazard mitigation, to understand current situation of each already-known active fault is urgently needed. After the 1999 Chi-chi earthquake shocked Taiwan, the Central Geological Survey (CGS) of Taiwan aggressively promoted the tasks on studying the activities of active faults. One of them is the deployment of miscellaneous monitoring networks to cover all the target areas, where the earthquake occurrence potentials on active faults are eager to be answered. Up to the end of 2007, CGS has already deployed over 1000 GPS campaign sites, 44 GPS stations in continuous mode, and 42 leveling transects across the major active faults with a total ground distance of 974 km. The campaign sites and leveling tasks have to be measured once a year. The resulted crustal deformation will be relied on to derive the fault slip model. The time series analysis on continuous mode of GPS can further help understand the details of the fault behavior. In addition, 12 down-hole strain meters, five stations for liquid flux and geochemical proxies, and two for water table monitoring have been also installed to seek possible anomalies related to the earthquake activities. It may help discover reliable earthquake precursors.

Anatomy of an Active Seismic Source: the Interplay between Present-Day Seismic Activity and Inherited Fault Zone Architecture (Central Apennines, Italy)

NASA Astrophysics Data System (ADS)

Fondriest, M.; Demurtas, M.; Bistacchi, A.; Fabrizio, B.; Storti, F.; Valoroso, L.; Di Toro, G.

2017-12-01

The mechanics and seismogenic behaviour of fault zones are strongly influenced by their internal structure, in terms of both fault geometry and fault rock constitutive properties. In recent years high-resolution seismological techniques yielded new constraints on the geometry and velocity structure of seismogenic faults down to 10s meters length scales. This reduced the gap between geophysical imaging of active seismic sources and field observations of exhumed fault zones. Nevertheless fundamental questions such as the origin of geometrical and kinematic complexities associated to seismic faulting remain open. We addressed these topics by characterizing the internal structure of the Vado di Corno Fault Zone, an active seismogenic normal fault cutting carbonates in the Central Apennines of Italy and comparing it with the present-day seismicity of the area. The fault footwall block, which was exhumed from < 2 km depth, was mapped with high detail (< 1 m spatial resolution) for 2 km of exposure along strike, combining field structural data and photogrammetric surveys in a three dimensional structural model. Three main structural units separated by principal fault strands were recognized: (i) cataclastic unit (20-100 m thick), (ii) damage zone (≤ 300 m thick), (iii) breccia unit ( 20 thick). The cataclastic unit lines the master fault and represents the core of the normal fault zone. In-situ shattering together with evidence of extreme (possibly coseismic) shear strain localization (e.g., mirror-like faults with truncated clasts, ultrafine-grained sheared veins) was recognized. The breccia unit is an inherited thrust zone affected by pervasive veining and secondary dolomitization. It strikes subparallel to the active normal fault and is characterized by a non-cylindrical geometry with 10-100 m long frontal and lateral ramps. The cataclastic unit cuts through thrust flats within the breccia unit, whereas normal to oblique inversion occur on frontal and lateral ramps. A comparable structural setting was imaged South-West of the study area, during the 2009 L'Aquila seismic sequence. Here at 2 km depth, the master normal fault cross-cuts a 10 km long flat structure and clear lateral ramps are illuminated, suggesting the superposition of normal seismic faulting on inherited compressional structures.

Neotectonics and geomorphic evolution of the northwestern arm of the Yellowstone Tectonic Parabola: Controls on intra-cratonic extensional regimes, southwest Montana

USGS Publications Warehouse

Ruleman, Chester A.; Larsen, Mort; Stickney, Michael C.

2014-01-01

The catastrophic Hebgen Lake earthquake of 18 August 1959 (MW 7.3) led many geoscientists to develop new methods to better understand active tectonics in extensional tectonic regimes that address seismic hazards. The Madison Range fault system and adjacent Hebgen Lake–Red Canyon fault system provide an intermountain active tectonic analog for regional analyses of extensional crustal deformation. The Madison Range fault system comprises fault zones (~100 km in length) that have multiple salients and embayments marked by preexisting structures exposed in the footwall. Quaternary tectonic activity rates differ along the length of the fault system, with less displacement to the north. Within the Hebgen Lake basin, the 1959 earthquake is the latest slip event in the Hebgen Lake–Red Canyon fault system and southern Madison Range fault system. Geomorphic and paleoseismic investigations indicate previous faulting events on both fault systems. Surficial geologic mapping and historic seismicity support a coseismic structural linkage between the Madison Range and Hebgen Lake–Red Canyon fault systems. On this trip, we will look at Quaternary surface ruptures that characterize prehistoric earthquake magnitudes. The one-day field trip begins and ends in Bozeman, and includes an overview of the active tectonics within the Madison Valley and Hebgen Lake basin, southwestern Montana. We will also review geologic evidence, which includes new geologic maps and geomorphic analyses that demonstrate preexisting structural controls on surface rupture patterns along the Madison Range and Hebgen Lake–Red Canyon fault systems.

Active tectonics of the Binalud Mountains, a key puzzle segment to describe Quaternary deformations at the northeastern boundary of the Arabia-Eurasia collision

NASA Astrophysics Data System (ADS)

Shabanian, Esmaeil; Bellier, Olivier; Siame, Lionel L.; Abbassi, Mohammad R.; Leanni, Laetitia; Braucher, Régis; Farbod, Yassaman; Bourlès, Didier L.

2010-05-01

In northeast Iran, the Binalud Mountains accommodate part of active convergence between the Arabian and Eurasian plates. This fault-bounded mountain range has been considered a key region to describe Quaternary deformations at the northeastern boundary of the Arabia-Eurasia collision. But, the lack of knowledge on active faulting hampered evaluating the geological reliability of tectonic models describing the kinematics of deformation in northeast Iran. Morphotectonic investigations along both sides of the Binalud Mountains allowed us to characterize the structural and active faulting patterns along the Neyshabur and Mashhad fault systems on the southwest and northeast sides of the mountain range, respectively. We applied combined approaches of morphotectonic analyses based on satellite imageries (SPOT5 and Landsat ETM+), STRM and site-scale digital topographic data, and field surveys complemented with in situ-produced 10Be exposure dating to determine the kinematics and rate of active faulting. Three regional episodes of alluvial surface abandonments were dated at 5.3±1.1 kyr (Q1), 94±5 kyr (Q3), and 200±14 kyr (S3). The geomorphic reconstruction of both vertical and right-lateral fault offsets postdating these surface abandonment episodes yielded Quaternary fault slip rates on both sides of the Binalud Mountains. On the Neyshabur Fault System, thanks to geomorphic reconstructions of cumulative offsets recorded by Q3 fan surfaces, slip rates of 2.7±0.8 mm/yr and 2.4±0.2 mm/yr are estimated for right-lateral and reverse components of active faulting, respectively. Those indicate a total slip rate of 3.6±1.2 mm/yr for the late Quaternary deformation on the southwest flank of the Binalud Mountains. Reconstructing the cumulative right-lateral offset recorded by S3 surfaces, a middle-late Quaternary slip rate of 1.6±0.1 mm/yr is determined for the Mashhad Fault System. Altogether, our geomorphic observations reveal that, on both sides of the Binalud Mountains, the relative motion between central Iran and Eurasia is partly taken-up by dextral-reverse oblique-slip faulting along the Neyshabur and Mashhad fault systems. This faulting mechanism implies a long-term rate of ~4 mm/yr for the range-parallel strike-slip faulting, and an uplift rate of ~2.4 mm/yr due to the range-normal shortening during late Quaternary. Our data provide the first geological constraints on the rate of active faulting on both sides of the Binalud Mountains, and allow us to examine the geological reliability of preexisting tectonic models proposed to describe the kinematics of active deformation at the northeastern boundary of the Arabia-Eurasia collision. Our results favor the northward translation of central Iran with respect to Eurasia through strike-slip faulting localized along distinct crustal scale fault systems rather than systematic block rotations around vertical axes.

Hydrogeochemistry Characteristics and Daily Variation of Geothermal Water in the Moxi Fault,Southwest of China

NASA Astrophysics Data System (ADS)

Qi, Jihong; Xu, Mo; An, Chenjiao; Zhang, Yunhui; Zhang, Qiang

2017-04-01

The Xianshuihe Fault with frequent earthquakes activities is the regional deep fault in China. The Moxi Fault is the southern part of the Xianshuihe Fault, where the strong activities of geothermal water could bring abundant information of deep crust. In this article, some typical geothermal springs were collected along the Moxi fault from Kangding to Shimian. Using the the Na-K-Mg equilibrium diagram, it explains the state of water-rock equilibrium, and estimates the reservoir temperature basing appropriate geothermometers. Basing on the relationship between the enthalpy and chlorine concentration of geothermal water, it analyze the mixing progress of thermal water with shallow groundwater. Moreover, the responses of variation of geothermal water to the solid tides are considered to study the hydrothermal activities of this fault. The Guanding in Kangding are considered as the center of the geothermal system, and the hydrothermal activities decrease southward extending. Geothermal water maybe is heated by the deep heat source of the Himalayan granites, while the springs in the south area perform the mixture with thermal water in the sub-reservoir of the Permian crystalline limestone. It improves the research of hydrothermal activities in the Moxi Fault, meanwhile using the variation of geothermal water maybe become a important method to study the environment of deep earth in the future.

The Devils Mountain Fault zone: An active Cascadia upper plate zone of deformation, Pacific Northwest of North America

NASA Astrophysics Data System (ADS)

Barrie, J. Vaughn; Greene, H. Gary

2018-02-01

The Devils Mountain Fault Zone (DMFZ) extends east to west from Washington State to just south of Victoria, British Columbia, in the northern Strait of Juan de Fuca of Canada and the USA. Recently collected geophysical data were used to map this fault zone in detail, which show the main fault trace, and associated primary and secondary (conjugate) strands, and extensive northeast-southwest oriented folding that occurs within a 6 km wide deformation zone. The fault zone has been active in the Holocene as seen in the offset and disrupted upper Quaternary strata, seafloor displacement, and deformation within sediment cores taken close to the seafloor expression of the faults. Data suggest that the present DMFZ and the re-activated Leech River Fault may be part of the same fault system. Based on the length and previously estimated slip rates of the fault zone in Washington State, the DMFZ appears to have the potential of producing a strong earthquake, perhaps as large as magnitude 7.5 or greater, within 2 km of the city of Victoria.

Modelling of hydrothermal fluid flow and structural architecture in an extensional basin, Ngakuru Graben, Taupo Rift, New Zealand

NASA Astrophysics Data System (ADS)

Kissling, W. M.; Villamor, P.; Ellis, S. M.; Rae, A.

2018-05-01

Present-day geothermal activity on the margins of the Ngakuru graben and evidence of fossil hydrothermal activity in the central graben suggest that a graben-wide system of permeable intersecting faults acts as the principal conduit for fluid flow to the surface. We have developed numerical models of fluid and heat flow in a regional-scale 2-D cross-section of the Ngakuru Graben. The models incorporate simplified representations of two 'end-member' fault architectures (one symmetric at depth, the other highly asymmetric) which are consistent with the surface locations and dips of the Ngakuru graben faults. The models are used to explore controls on buoyancy-driven convective fluid flow which could explain the differences between the past and present hydrothermal systems associated with these faults. The models show that the surface flows from the faults are strongly controlled by the fault permeability, the fault system architecture and the location of the heat source with respect to the faults in the graben. In particular, fault intersections at depth allow exchange of fluid between faults, and the location of the heat source on the footwall of normal faults can facilitate upflow along those faults. These controls give rise to two distinct fluid flow regimes in the fault network. The first, a regular flow regime, is characterised by a nearly unchanging pattern of fluid flow vectors within the fault network as the fault permeability evolves. In the second, complex flow regime, the surface flows depend strongly on fault permeability, and can fluctuate in an erratic manner. The direction of flow within faults can reverse in both regimes as fault permeability changes. Both flow regimes provide insights into the differences between the present-day and fossil geothermal systems in the Ngakuru graben. Hydrothermal upflow along the Paeroa fault seems to have occurred, possibly continuously, for tens of thousands of years, while upflow in other faults in the graben has switched on and off during the same period. An asymmetric graben architecture with the Paeroa being the major boundary fault will facilitate the predominant upflow along this fault. Upflow on the axial faults is more difficult to explain with this modelling. It occurs most easily with an asymmetric graben architecture and heat sources close to the graben axis (which could be associated with remnant heat from recent eruptions from Okataina Volcanic Centre). Temporal changes in upflow can also be associated with acceleration and deceleration of fault activity if this is considered a proxy for fault permeability. Other explanations for temporal variations in hydrothermal activity not explored here are different permeability on different faults, and different permeability along fault strike.

Fault tectonics and earthquake hazards in parts of southern California. [penninsular ranges, Garlock fault, Salton Trough area, and western Mojave Desert

NASA Technical Reports Server (NTRS)

Merifield, P. M. (Principal Investigator); Lamar, D. L.; Gazley, C., Jr.; Lamar, J. V.; Stratton, R. H.

1976-01-01

The author has identified the following significant results. Four previously unknown faults were discovered in basement terrane of the Peninsular Ranges. These have been named the San Ysidro Creek fault, Thing Valley fault, Canyon City fault, and Warren Canyon fault. In addition fault gouge and breccia were recognized along the San Diego River fault. Study of features on Skylab imagery and review of geologic and seismic data suggest that the risk of a damaging earthquake is greater along the northwestern portion of the Elsinore fault than along the southeastern portion. Physiographic indicators of active faulting along the Garlock fault identifiable in Skylab imagery include scarps, linear ridges, shutter ridges, faceted ridges, linear valleys, undrained depressions and offset drainage. The following previously unrecognized fault segments are postulated for the Salton Trough Area: (1) An extension of a previously known fault in the San Andreas fault set located southeast of the Salton Sea; (2) An extension of the active San Jacinto fault zone along a tonal change in cultivated fields across Mexicali Valley ( the tonal change may represent different soil conditions along opposite sides of a fault). For the Skylab and LANDSAT images studied, pseudocolor transformations offer no advantages over the original images in the recognition of faults in Skylab and LANDSAT images. Alluvial deposits of different ages, a marble unit and iron oxide gossans of the Mojave Mining District are more readily differentiated on images prepared from ratios of individual bands of the S-192 multispectral scanner data. The San Andreas fault was also made more distinct in the 8/2 and 9/2 band ratios by enhancement of vegetation differences on opposite sides of the fault. Preliminary analysis indicates a significant earth resources potential for the discrimination of soil and rock types, including mineral alteration zones. This application should be actively pursued.

Temporal evolution of fault systems in the Upper Jurassic of the Central German Molasse Basin: case study Unterhaching

NASA Astrophysics Data System (ADS)

Budach, Ingmar; Moeck, Inga; Lüschen, Ewald; Wolfgramm, Markus

2018-03-01

The structural evolution of faults in foreland basins is linked to a complex basin history ranging from extension to contraction and inversion tectonics. Faults in the Upper Jurassic of the German Molasse Basin, a Cenozoic Alpine foreland basin, play a significant role for geothermal exploration and are therefore imaged, interpreted and studied by 3D seismic reflection data. Beyond this applied aspect, the analysis of these seismic data help to better understand the temporal evolution of faults and respective stress fields. In 2009, a 27 km2 3D seismic reflection survey was conducted around the Unterhaching Gt 2 well, south of Munich. The main focus of this study is an in-depth analysis of a prominent v-shaped fault block structure located at the center of the 3D seismic survey. Two methods were used to study the periodic fault activity and its relative age of the detected faults: (1) horizon flattening and (2) analysis of incremental fault throws. Slip and dilation tendency analyses were conducted afterwards to determine the stresses resolved on the faults in the current stress field. Two possible kinematic models explain the structural evolution: One model assumes a left-lateral strike slip fault in a transpressional regime resulting in a positive flower structure. The other model incorporates crossing conjugate normal faults within a transtensional regime. The interpreted successive fault formation prefers the latter model. The episodic fault activity may enhance fault zone permeability hence reservoir productivity implying that the analysis of periodically active faults represents an important part in successfully targeting geothermal wells.

Shallow seismic imaging of folds above the Puente Hills blind-thrust fault, Los Angeles, California

USGS Publications Warehouse

Pratt, T.L.; Shaw, J.H.; Dolan, J.F.; Christofferson, S.A.; Williams, R.A.; Odum, J.K.; Plesch, A.

2002-01-01

High-resolution seismic reflection profiles image discrete folds in the shallow subsurface (<600 m) above two segments of the Puente Hills blind-thrust fault system, Los Angeles basin, California. The profiles demonstrate late Quaternary activity at the fault tip, precisely locate the axial surfaces of folds within the upper 100 m, and constrain the geometry and kinematics of recent folding. The Santa Fe Springs segment of the Puente Hills fault zone shows an upward-narrowing kink band with an active anticlinal axial surface, consistent with fault-bend folding above an active thrust ramp. The Coyote Hills segment shows an active synclinal axial surface that coincides with the base of a 9-m-high scarp, consistent with tip-line folding or the presence of a backthrust. The seismic profiles pinpoint targets for future geologic work to constrain slip rates and ages of past events on this important fault system.

Identification and interpretation of tectonic features from Skylab imagery. [California to Arizona

NASA Technical Reports Server (NTRS)

Abdel-Gawad, M. (Principal Investigator)

1974-01-01

The author has identified the following significant results. S190-B imagery confirmed previous conclusions from S190-A that the Garlock fault does not extend eastward beyond its known termination near the southern end of Death Valley. In the Avawatz Mountains, California, two faults related to the Garlock fault zone (Mule Spring fault and Leach Spring fault) show evidence of recent activity. There is evidence that faulting related to Death Valley fault zone extends southeastward across the Old Dad Mountains. There, the Old Dad fault shows evidence of recent activity. A significant fault lineament has been identified from McCullough Range, California southeastward to Eagle Tail Mountains in southwestern Arizona. The lineament appears to control tertiary and possible cretaceous intrusives. Considerable right lateral shear is suspected to have taken place along parts of this lineament.

Late Quaternary Faulting along the San Juan de los Planes Fault Zone, Baja California Sur, Mexico

NASA Astrophysics Data System (ADS)

Busch, M. M.; Coyan, J. A.; Arrowsmith, J.; Maloney, S. J.; Gutierrez, G.; Umhoefer, P. J.

2007-12-01

As a result of continued distributed deformation in the Gulf Extensional Province along an oblique-divergent plate margin, active normal faulting is well manifest in southeastern Baja California. By characterizing normal-fault related deformation along the San Juan de los Planes fault zone (SJPFZ) southwest of La Paz, Baja California Sur we contribute to understanding the patterns and rates of faulting along the southwest gulf-margin fault system. The geometry, history, and rate of faulting provide constraints on the relative significance of gulf-margin deformation as compared to axial system deformation. The SJPFZ is a major north-trending structure in the southern Baja margin along which we focused our field efforts. These investigations included: a detailed strip map of the active fault zone, including delineation of active scarp traces and geomorphic surfaces on the hanging wall and footwall; fault scarp profiles; analysis of bedrock structures to better understand how the pattern and rate of strain varied during the development of this fault zone; and a gravity survey across the San Juan de los Planes basin to determine basin geometry and fault behavior. The map covers a N-S swath from the Gulf of California in the north to San Antonio in the south, an area ~45km long and ~1-4km wide. Bedrock along the SJPFZ varies from Cretaceous Las Cruces Granite in the north to Cretaceous Buena Mujer Tonalite in the south and is scarred by shear zones and brittle faults. The active scarp-forming fault juxtaposes bedrock in the footwall against Late Quaternary sandstone-conglomerate. This ~20m wide zone is highly fractured bedrock infused with carbonate. The northern ~12km of the SJPFZ, trending 200°, preserves discontinuous scarps 1-2km long and 1-3m high in Quaternary units. The scarps are separated by stretches of bedrock embayed by hundreds of meters-wide tongues of Quaternary sandstone-conglomerate, implying low Quaternary slip rate. Further south, ~2 km north of the Los Planes highway, the fault steps to the right 2km with no overlap. The fault is inactive until ~3km south of the Los Planes highway where scarp heights in the Quaternary sediments rise to ~3-11m for ~11km with an average trend of 160°, implying increasing slip rate. The fault then steps left 2km with no overlap, trending 145°. Scarp heights range from 3-6m in the step. The southernmost 9km of the fault zone, trending 200°, is marked by discontinuous scarps and embayed bedrock, reflecting diminished fault activity. The footwall landscape in this area is characterized by a broad, gently-sloping, low-relief pediment surface with thin Quaternary cover, disrupted by inselberg-like hills. The young scarp-forming fault appears to have reactivated older faults to rupture this pediment, reflecting the episodic nature of slip along this fault zone. Preliminary OSL ages of the youngest faulted deposit imply a Late Pleistocene-Holocene slip rate of 0.1-1mm/yr. The SJPFZ is thus characterized by reactivation of pre-existing faults to rupture a pre-existing low relief erosional landscape. Whereas the entire region might have experienced the quiescent period that allowed for development of the low- relief, stable surface along the SJPFZ, we speculate that while the SJPFZ was dormant, other faults within the gulf-margin system were actively accommodating strain.

Recently active traces of the Bartlett Springs Fault, California: a digital database

USGS Publications Warehouse

Lienkaemper, James J.

2010-01-01

The purpose of this map is to show the location of and evidence for recent movement on active fault traces within the Bartlett Springs Fault Zone, California. The location and recency of the mapped traces is primarily based on geomorphic expression of the fault as interpreted from large-scale aerial photography. In a few places, evidence of fault creep and offset Holocene strata in trenches and natural exposures have confirmed the activity of some of these traces. This publication is formatted both as a digital database for use within a geographic information system (GIS) and for broader public access as map images that may be browsed on-line or download a summary map. The report text describes the types of scientific observations used to make the map, gives references pertaining to the fault and the evidence of faulting, and provides guidance for use of and limitations of the map.

Multifaulting in a tectonic syntaxis revealed by InSAR: The case of the Ziarat earthquake sequence (Pakistan)

NASA Astrophysics Data System (ADS)

Pinel-Puysségur, B.; Grandin, R.; Bollinger, L.; Baudry, C.

2014-07-01

On 28-29 October 2008, within 12 h, two similar Mw = 6.4 strike-slip earthquakes struck Baluchistan (Pakistan), as part of a complex seismic sequence. Interferometric Synthetic Aperture Radar (InSAR) data reveal that the peak of surface displacement is near the Ziarat anticline, a large active fold affected by Quaternary strike-slip faulting. All coseismic interferograms integrate the deformation due to both earthquakes. As their causative faults ruptured close to each other, the individual signals cannot be separated. According to their focal mechanisms, each earthquake may have activated a NE-SW sinistral or a NW-SE dextral fault segment, which leads to four possible scenarios of fault orientations. A nonlinear inversion of the InSAR data set allows rejecting two scenarios. The best slip distributions on the two fault segments for the two remaining scenarios are determined by linear inversion. Stress-change modeling favors a scenario involving two abutting conjugate strike-slip faults. Two other fault segments accommodated left-lateral strike slip during the seismic sequence. The activated fault system includes multiple fault segments with different orientations and little surface expression. This may highlight, at a smaller scale, the distributed, possibly transient character of deformation within a broader right-lateral shear zone. It suggests that the activated faults delineate a small tectonic block extruding and subtly rotating within the shear zone. It occurs in the vicinity of the local tectonic syntaxis where orogenic structures sharply turn around a vertical axis. These mechanisms could participate in the long-term migration of active tectonic structures within this kinematically unstable tectonic syntaxis.

Seismicity and Tectonics of the West Kaibab Fault Zone, AZ

NASA Astrophysics Data System (ADS)

Wilgus, J. T.; Brumbaugh, D. S.

2014-12-01

The West Kaibab Fault Zone (WKFZ) is the westernmost bounding structure of the Kaibab Plateau of northern Arizona. The WKFZ is a branching complex of high angle, normal faults downthrown to the west. There are three main faults within the WKFZ, the Big Springs fault with a maximum of 165 m offset, the Muav fault with 350 m of displacement, and the North Road fault having a maximum throw of approximately 90 m. Mapping of geologically recent surface deposits at or crossing the fault contacts indicates that the faults are likely Quaternary with the most recent offsets occurring <1.6 Ma. Slip rates are estimated to be less than 0.2 mm/yr. No historic fault slip has been documented. The WKFZ is one of the most seismically active areas in Arizona and lies within the Northern Arizona Seismic Belt (NASB), which stretches across northern Arizona trending NW-SE. The data set for this study includes 156 well documented events with the largest being a M5.75 in 1959 and including a swarm of seven earthquakes in 2012. The seismic data set (1934-2014) reveals that seismic activity clusters in two regions within the study area, the Fredonia cluster located in the NW corner of the study area and the Kaibab cluster located in the south central portion of the study area. The fault plane solutions to date indicate NE-SW to EW extension is occurring in the study area. Source relationships between earthquakes and faults within the WKFZ have not previously been studied in detail. The goal of this study is to use the seismic data set, the available data on faults, and the regional physiography to search for source relationships for the seismicity. Analysis includes source parameters of the earthquake data (location, depth, and fault plane solutions), and comparison of this output to the known faults and areal physiographic framework to indicate any active faults of the WKFZ, or suggested active unmapped faults. This research contributes to a better understanding of the present nature of the WKFZ and the NASB as well.

Subsurface Resistivity Structures in and Around Strike-Slip Faults - Electromagnetic Surveys and Drillings Across Active Faults in Central Japan -

NASA Astrophysics Data System (ADS)

Omura, K.; Ikeda, R.; Iio, Y.; Matsuda, T.

2005-12-01

Electrical resistivity is important property to investigate the structure of active faults. Pore fluid affect seriously the electrical properties of rocks, subsurface electrical resistivity can be an indicator of the existence of fluid and distribution of pores. Fracture zone of fault is expected to have low resistivity due to high porosity and small gain size. Especially, strike-slip type fault has nearly vertical fracture zone and the fracture zone would be detected by an electrical survey across the fault. We performed electromagnetic survey across the strike-slip active faults in central Japan. At the same faults, we also drilled borehole into the fault and did downhole logging in the borehole. We applied MT or CSAMT methods onto 5 faults: Nojima fault which appeared on the surface by the 1995 Great Kobe earthquake (M=7.2), western Nagano Ohtaki area(1984 Nagano-ken seibu earthquake (M=6.8), the fault did not appeared on the surface), Neodani fault which appeared by the 1891 Nobi earthquake (M=8.0), Atera fault which seemed to be dislocated by the 1586 Tensyo earthquake (M=7.9), Gofukuji fault that is considered to have activated about 1200 years ago. The sampling frequencies of electrical and magnetic field were 2 - 1024Hz (10 frequencies) for CSAMT survey and 0.00055 - 384Hz (40 frequencies) for MT survey. The electromagnetic data were processed by standard method and inverted to 2-D resistivity structure along transects of the faults. Results of the survey were compared with downhole electrical logging data and observational descriptions of drilled cores. Fault plane of each fault were recognized as low resistivity region or boundary between relatively low and high resistivity region, except for Gofukuji fault. As for Gofukuji fault, fault was located in relatively high resistivity region. During very long elapsed time from the last earthquake, the properties of fracture zone of Gofukuji fault might changed from low resistivity properties as observed for other faults. Downhole electrical logging data were consistent to values of resistivity estimated by electromagnetic survey for each fault. The existence of relatively low and high resistivity regions in 2-D structure from electromagnetic survey was observed again by downhole logging at the correspondent portion in the borehole. Cores recovered from depthes where the electrical logging showed low resistivity were hardly fractured and altered from host rock which showed high resistivity. Results of electromagnetic survey, downhole electrical logging and observation of drilled cores were consistent to each other. In present case, electromagnetic survey is useful to explore the properties of fault fracture zone. In the further investigations, it is important to explore relationships among features of resistivity structure and geological and geophysical situations of the faults.

Do mesoscale faults near the tip of an active strike-slip fault indicate regional or local stress?

NASA Astrophysics Data System (ADS)

Yamaji, Atsushi

2017-04-01

Fault-slip analysis is used in Japan after the Great Tohoku Earthquake (2011) to judge the stability of fractures in the foundations of nuclear power plants. In case a fault-slip datum from a fracture surface is explained by the present stress condition, the fracture is thought to have a risk to be activated as a fault. So, it is important to understand the relative significance of regional and local stresses. To answer the question whether mesoscale faults indicate regional or local stress, fault-slip data were collected from the walls of a trenching site of the Nojima Fault in central Japan—an active, dextral, strike-slip fault. The fault gave rise to the 1995 Kobe earthquake, which killed more than 6000 people. The trench was placed near the fault tip, which produced compressional and extensional local stress conditions on the sides of the fault near the tip. A segment of the fault, which ruptured the surface in 1995, bounded Cretaceous granite and latest Pliocene sediments in the trench. As a result, the stress inversion of the data from the mesoscale faults observed in the trench showed both the local stresses. The present WNW-ESE regional compression was found from the compressive side, but was not in the extensional side, probably because local extension surpassed the regional compression. Instead, the regional N-S compression of the Early Pleistocene was found from the extensional side. From this project, we got the lesson that fault-slip analysis reveals regional and local stresses, and that local stress sometimes masks regional one. This work was supported by a science project of "Drilling into Fault Damage Zone" (awarded to A. Lin) of the Secretariat of Nuclear Regulation Authority (Japan).

Mantle fault zone beneath Kilauea Volcano, Hawaii.

PubMed

Wolfe, Cecily J; Okubo, Paul G; Shearer, Peter M

2003-04-18

Relocations and focal mechanism analyses of deep earthquakes (>/=13 kilometers) at Kilauea volcano demonstrate that seismicity is focused on an active fault zone at 30-kilometer depth, with seaward slip on a low-angle plane, and other smaller, distinct fault zones. The earthquakes we have analyzed predominantly reflect tectonic faulting in the brittle lithosphere rather than magma movement associated with volcanic activity. The tectonic earthquakes may be induced on preexisting faults by stresses of magmatic origin, although background stresses from volcano loading and lithospheric flexure may also contribute.

Mantle fault zone beneath Kilauea Volcano, Hawaii

USGS Publications Warehouse

Wolfe, C.J.; Okubo, P.G.; Shearer, P.M.

2003-01-01

Relocations and focal mechanism analyses of deep earthquakes (???13 kilometers) at Kilauea volcano demonstrate that seismicity is focused on an active fault zone at 30-kilometer depth, with seaward slip on a low-angle plane, and other smaller, distinct fault zones. The earthquakes we have analyzed predominantly reflect tectonic faulting in the brittle lithosphere rather than magma movement associated with volcanic activity. The tectonic earthquakes may be induced on preexisting faults by stresses of magmatic origin, although background stresses from volcano loading and lithospheric flexure may also contribute.

Frictional and hydraulic behaviour of carbonate fault gouge during fault reactivation - An experimental study

NASA Astrophysics Data System (ADS)

Delle Piane, Claudio; Giwelli, Ausama; Clennell, M. Ben; Esteban, Lionel; Nogueira Kiewiet, Melissa Cristina D.; Kiewiet, Leigh; Kager, Shane; Raimon, John

2016-10-01

We present a novel experimental approach devised to test the hydro-mechanical behaviour of different structural elements of carbonate fault rocks during experimental re-activation. Experimentally faulted core plugs were subject to triaxial tests under water saturated conditions simulating depletion processes in reservoirs. Different fault zone structural elements were created by shearing initially intact travertine blocks (nominal size: 240 × 110 × 150 mm) to a maximum displacement of 20 and 120 mm under different normal stresses. Meso-and microstructural features of these sample and the thickness to displacement ratio characteristics of their deformation zones allowed to classify them as experimentally created damage zones (displacement of 20 mm) and fault cores (displacement of 120 mm). Following direct shear testing, cylindrical plugs with diameter of 38 mm were drilled across the slip surface to be re-activated in a conventional triaxial configuration monitoring the permeability and frictional behaviour of the samples as a function of applied stress. All re-activation experiments on faulted plugs showed consistent frictional response consisting of an initial fast hardening followed by apparent yield up to a friction coefficient of approximately 0.6 attained at around 2 mm of displacement. Permeability in the re-activation experiments shows exponential decay with increasing mean effective stress. The rate of permeability decline with mean effective stress is higher in the fault core plugs than in the simulated damage zone ones. It can be concluded that the presence of gouge in un-cemented carbonate faults results in their sealing character and that leakage cannot be achieved by renewed movement on the fault plane alone, at least not within the range of slip measureable with our apparatus (i.e. approximately 7 mm of cumulative displacement). Additionally, it is shown that under sub seismic slip rates re-activated carbonate faults remain strong and no frictional weakening was observed during re-activation.

Role of the offshore Pedro Banks left-lateral strike-slip fault zone in the plate tectonic evolution of the northern Caribbean

NASA Astrophysics Data System (ADS)

Ott, B.; Mann, P.; Saunders, M.

2013-12-01

Previous workers, mainly mapping onland active faults on Caribbean islands, defined the northern Caribbean plate boundary zone as a 200-km-wide bounded by two active and parallel strike-slip faults: the Oriente fault along the northern edge of the Cayman trough with a GPS rate of 14 mm/yr, and and the Enriquillo-Plaintain Garden fault zone (EPGFZ) with a rate of 5-7 mm/yr. In this study we use 5,000 km of industry and academic data from the Nicaraguan Rise south and southwest of the EPGFZ in the maritime areas of Jamaica, Honduras, and Colombia to define an offshore, 700-km-long, active, left-lateral strike-slip fault in what has previously been considered the stable interior of the Caribbean plate as determined from plate-wide GPS studies. The fault was named by previous workers as the Pedro Banks fault zone because a 100-km-long segment of the fault forms an escarpment along the Pedro carbonate bank of the Nicaraguan Rise. Two fault segments of the PBFZ are defined: the 400-km-long eastern segment that exhibits large negative flower structures 10-50 km in width, with faults segments rupturing the sea floor as defined by high resolution 2D seismic data, and a 300-km-long western segment that is defined by a narrow zone of anomalous seismicity first observed by previous workers. The western end of the PBFZ terminates on a Quaternary rift structure, the San Andres rift, associated with Plio-Pleistocene volcanism and thickening trends indicating initial rifting in the Late Miocene. The southern end of the San Andreas rift terminates on the western Hess fault which also exhibits active strands consistent with left-lateral, strike-slip faults. The total length of the PBFZ-San Andres rift-Southern Hess escarpment fault is 1,200 km and traverses the entire western end of the Caribbean plate. Our interpretation is similar to previous models that have proposed the "stable" western Caribbean plate is broken by this fault whose rate of displacement is less than the threshold recognizable from the current GPS network (~3 mm/yr). The Late Miocene age of the fault indicates it may have activated during the Late Miocene to recent Hispaniola-Bahamas oblique collision event.

Fault zone structure from topography: signatures of en echelon fault slip at Mustang Ridge on the San Andreas Fault, Monterey County, California

USGS Publications Warehouse

DeLong, Stephen B.; Hilley, George E.; Rymer, Michael J.; Prentice, Carol

2010-01-01

We used high-resolution topography to quantify the spatial distribution of scarps, linear valleys, topographic sinks, and oversteepened stream channels formed along an extensional step over on the San Andreas Fault (SAF) at Mustang Ridge, California. This location provides detail of both creeping fault landform development and complex fault zone kinematics. Here, the SAF creeps 10–14 mm/yr slower than at locations ∼20 km along the fault in either direction. This spatial change in creep rate is coincident with a series of en echelon oblique-normal faults that strike obliquely to the SAF and may accommodate the missing deformation. This study presents a suite of analyses that are helpful for proper mapping of faults in locations where high-resolution topographic data are available. Furthermore, our analyses indicate that two large subsidiary faults near the center of the step over zone appear to carry significant distributed deformation based on their large apparent vertical offsets, the presence of associated sag ponds and fluvial knickpoints, and the observation that they are rotating a segment of the main SAF. Several subsidiary faults in the southeastern portion of Mustang Ridge are likely less active; they have few associated sag ponds and have older scarp morphologic ages and subdued channel knickpoints. Several faults in the northwestern part of Mustang Ridge, though relatively small, are likely also actively accommodating active fault slip based on their young morphologic ages and the presence of associated sag ponds.

The relationship of near-surface active faulting to megathrust splay fault geometry in Prince William Sound, Alaska

NASA Astrophysics Data System (ADS)

Finn, S.; Liberty, L. M.; Haeussler, P. J.; Northrup, C.; Pratt, T. L.

2010-12-01

We interpret regionally extensive, active faults beneath Prince William Sound (PWS), Alaska, to be structurally linked to deeper megathrust splay faults, such as the one that ruptured in the 1964 M9.2 earthquake. Western PWS in particular is unique; the locations of active faulting offer insights into the transition at the southern terminus of the previously subducted Yakutat slab to Pacific plate subduction. Newly acquired high-resolution, marine seismic data show three seismic facies related to Holocene and older Quaternary to Tertiary strata. These sediments are cut by numerous high angle normal faults in the hanging wall of megathrust splay. Crustal-scale seismic reflection profiles show splay faults emerging from 20 km depth between the Yakutat block and North American crust and surfacing as the Hanning Bay and Patton Bay faults. A distinct boundary coinciding beneath the Hinchinbrook Entrance causes a systematic fault trend change from N30E in southwestern PWS to N70E in northeastern PWS. The fault trend change underneath Hinchinbrook Entrance may occur gradually or abruptly and there is evidence for similar deformation near the Montague Strait Entrance. Landward of surface expressions of the splay fault, we observe subsidence, faulting, and landslides that record deformation associated with the 1964 and older megathrust earthquakes. Surface exposures of Tertiary rocks throughout PWS along with new apatite-helium dates suggest long-term and regional uplift with localized, fault-controlled subsidence.

Active faults system and related potential seismic events near Ulaanbaatar, capital of Mongolia.

NASA Astrophysics Data System (ADS)

Schlupp, Antoine; Ferry, Matthieu; Munkhuu, Ulziibat; Sodnomsambuu, Demberel; Al-Ashkar, Abeer

2013-04-01

The region of Ulaanbaatar lies several hundred kilometers from large known active faults that produced magnitude 6 to 8+ earthquakes during the last century. Beside the Hustai fault, which displays a clear morphological expression, no active fault was previously described less than 100 km from the city. In addition, no large historical (i.e. more recent than the 16th c.) earthquakes are known in this region. However, since 2005 a very dense seismic activity has developed over the Emeelt Township area, a mere 10 km from Ulaanbaatar. The activity is characterized by numerous low magnitude events (M<2.8), which are distributed linearly along several tens of kilometers where no active fault has been identified. This raises several questions: Is this seismicity associated to a -yet- unknown active fault? If so, are there other unknown active faults near Ulaanbaatar? Hence, we deployed a multi-disciplinary approach including morpho-tectonic, near-surface geophysical and paleoseismological investigations. We describe four large active faults west and south of Ulaanbaatar, three of them are newly discovered (Emeelt, Sharai, Avdar), one was previously known (Hustai) but without precise study on its seismic potential. The Emeelt seismicity can be mapped over 35 km along N150 and corresponds in the field to a smoothed, but clear, active fault morphology that can be mapped along a 10-km-long section. The fault dips at ~30° NE (GPR and surface morphology observations) and uplifts the eastern block. The age of the last surface rupture observed in trenches is about 10 ka (preliminary OSL dating). Considering a rupture length of 35 km, a full segment rupture would be comparable to the 1967 Mogod earthquake with a magnitude as large as Mw 7. It has to be considered today as a possible scenario for the seismic risk of Ulaanbaatar. The 90-km-long Hustai Range Fault System, oriented WSW-ENE and located about 10 km west of Ulaanbaatar, displays continuous microseismicity with five light to moderate (M 4 - 5.4) earthquakes over the last 40 years. The last surface-rupturing earthquake occurred about 1000 years ago (OSL dating). Alluvial fans affected by the fault suggest the rate of deformation (left lateral with normal component) along the main segment ranges from 0.3 to 0.4 mm/year for the last 120 000 years. Hence, the average recurrence interval for a full-segment M 7-7.5 is likely in the order of 10 ky. However, if the Hustai fault also releases strain during partial ruptures along its strongly segmented trace, a Mw 6.5 event may be expected anytime. However, only the main central fault segment has been investigated in terms of paleoseismicity. The Sharai and Avdar faults, oriented NNE-SSW, were mapped along ~50-km-long sections. Each of these faults was the site of earthquakes of magnitude 6 and more in the past as suggested by morphology and trench observations. Full-segment-ruptures could produce events as large as M 7.2. The precise relationship and interactions between these faults as well as associated earthquakes have to be clarified by collecting more data. They are the key of the seismic hazard and risk of Ulaanbaatar.

FTAPE: A fault injection tool to measure fault tolerance

NASA Technical Reports Server (NTRS)

Tsai, Timothy K.; Iyer, Ravishankar K.

1995-01-01

The paper introduces FTAPE (Fault Tolerance And Performance Evaluator), a tool that can be used to compare fault-tolerant computers. The tool combines system-wide fault injection with a controllable workload. A workload generator is used to create high stress conditions for the machine. Faults are injected based on this workload activity in order to ensure a high level of fault propagation. The errors/fault ratio and performance degradation are presented as measures of fault tolerance.

Latest Rate, Extent, and Temporal Evolution of Growth Faulting over Greater Houston Region Revealed by Multi- Band InSAR Time-Series Analysis

NASA Astrophysics Data System (ADS)

Qu, F.; Lu, Z.; Kim, J. W.

2017-12-01

Growth faults are common and continue to evolve throughout the unconsolidated sediments of Greater Houston (GH) region in Texas. Presence of faults can induce localized surface displacements, aggravate localized subsidence, and discontinue the integrity of ground water flow. Property damages due to fault creep have become more evident during the past few years over the GH area, portraying the necessity of further study of these faults. Interferometric synthetic aperture radar (InSAR) has been proven to be effective in mapping creep along and/or across faults. However, extracting a short wavelength, as well as small amplitude of the creep signal (about 10-20 mm/year) from long time span interferograms is extremely difficult, especially in agricultural or vegetated areas. This paper aims to map and monitor the latest rate, extent, and temporal evolution of faulting at a highest spatial density over GH region using an improved Multi-temporal InSAR (MTI) technique. The method, with maximized usable signal and correlation, has the ability to identify and monitor the active faults to provide an accurate and elaborate image of the faults. In this study, two neighboring ALOS tracks and Sentinel-1A datasets are used. Many zones of steep phase gradients and/or discontinuities have been recognized from the long term velocity maps by both ALOS (2007-2011) and Sentinei-1A (2015-2017) imagery. Not only those previously known faults position but also the new fault traces that have not been mapped by other techniques are imaged by our MTI technique. Fault damage and visible cracking of ground were evident at most locations through our field survey. The discovery of new fault activation, or faults moved from earlier locations is a part of the Big Barn Fault and Conroe fault system, trending from southwest to northeast between Hockley and Conroe. The location of area of subsidence over GH is also shrinking and migrating toward the northeast (Montgomery County) after 2000. The continuous mining of ground water from the Jasper aquifer formed a new water-level decline cones over Montgomery County, exactly reflects the intensity of new fault activity. The discovery of new fault activation, or faults moved from earlier locations appear to be related to excessive water exploitation from Montgomery County aquifers.

Geomorphic Proxies to Test Strain Accommodation in Southwestern Puerto Rico from Digital Elevation Models

NASA Astrophysics Data System (ADS)

Barrios Galindez, I. M.; Xue, L.; Laó-Dávila, D. A.

2017-12-01

The Puerto Rico and the Virgin Island microplate is located in at the northeastern corner of the Caribbean plate boundary with North America is placed within an oblique subduction zone in which strain patterns remain unresolved. Seismic hazard is a major concern in the region as seen from the seismic history of the Caribbean-North America plate boundary zone. Most of the tectonic models of the microplate show the accommodation of strain occurring offshore, despite evidence from seismic activity, trench studies, and geodetic studies suggesting the existence of strain accomodation in southwest Puerto Rico. These studies also suggest active faulting specially in the western part of the island, but limited work has been done regarding their mechanism. Therefore, this work aims to define and map these active faults in western Puerto Rico by integrating data from analysis of fluvial terrains, and detailed mapping using digital elevation model (DEM) extracted from Shuttle Radar Topography Mission (SRTM) and LIDAR data. The goal is to (1) identify structural features such as surface lineaments and fault scarps for the Cerro Goden fault, South Lajas fault, and other active faults in the western of Puerto Rico, (2) correlate these information with the distribution pattern and values of the geomorphic proxies, including Chi integral (χ), normalized steepness (ksn) and Asymmetric factor (AF). Our preliminary results from geomorphic proxies and Lidar data provide some insight of the displacement and stage of activities of these faults (e.g. Boqueron-Punta Malva Fault and Cerro Goden fault). Also, the anomaly of the geomorphic proxies generally correlate with the locations of the landslides in the southwestern Puerto Rico. The geomorphic model of this work include new information of active faulting fundamental to produce better seismic hazards maps. Additionally, active tectonics studies are vital to issue and adjust construction buildings codes and zonification codes.

Integration of high-resolution seismic and aeromagnetic data for earthquake hazards evaluations: An example from the Willamette Valley, Oregon

USGS Publications Warehouse

Liberty, L.M.; Trehu, A.M.; Blakely, R.J.; Dougherty, M.E.

1999-01-01

Aeromagnetic and high-resolution seismic reflection data were integrated to place constraints on the history of seismic activity and to determine the continuity of the possibly active, yet largely concealed Mount Angel fault in the Willamette Valley, Oregon. Recent seismic activity possibly related to the 20-km-long fault includes a swarm of small earthquakes near Woodburn in 1990 and the magnitude 5.6 Scotts Mills earthquake in 1993. Newly acquired aeromagnetic data show several large northwest-trending anomalies, including one associated with the Mount Angel fault. The magnetic signature indicates that the fault may actually extend 70 km across the Willamette Valley to join the Newberg and Gales Creek faults in the Oregon Coast Range. We collected 24-fold high-resolution seismic reflection data along two transects near Woodburn, Oregon, to image the offset of the Miocene-age Columbia River Basalts (CRB) and overlying sediments at and northwest of the known mapped extent of the Mount Angel fault. The seismic data show a 100-200-m offset in the CRB reflector at depths from 300 to 700 m. Folded or offset sediments appear above the CRB with decreasing amplitude to depths as shallow as were imaged (approximately 40 m). Modeling experiments based on the magnetic data indicate, however, that the anomaly associated with the Mount Angel fault is not caused solely by an offset of the CRB and overlying sediments. Underlying magnetic sources, which we presume to be volcanic rocks of the Siletz terrane, must have vertical offsets of at least 500 m to fit the observed data. We conclude that the Mount Angel fault appears to have been active since Eocene age and that the Gales Creek, Newberg, and Mount Angel faults should be considered a single potentially active fault system. This fault, as well as other parallel northwest-trending faults in the Willamette Valley, should be considered as risks for future potentially damaging earthquakes.

Implications of river morphology response to Dien Bien Phu fault in NW Vietnam

NASA Astrophysics Data System (ADS)

Lai, K.; Chen, Y.; Lam, D.

2007-12-01

In northern Vietnam, most rivers are flowing southeastward sub- or parallel to the valley of Red River and characterized by long but narrow catchments. The Dien Bien Phu fault is associated with the most seismically active zone in Vietnam and situated in the potential eastern boundary of the rotating southeastern Tibetan block. It cuts the Da River, the largest tributary of Red River in northwest Vietnam and has distorted the drainage basin resulting in complex river patterns. To assess the river morphology response to active Dien Bien Phu fault, we use 1/50,000 topographic data and ASTER images to map the precise river courses and digital elevation model data of SRTM to retrieve and analyze the river profiles. From the mapping results, the N-S striking fault results in three conspicuous north-trending river valleys coincided with the different fault segments to facilitate the measurement and reconstruction of the offsets along the fault. Further combining the longitudinal profile analysis we obtain ca. 10 km offsets by deflected river as the largest left-lateral displacement recorded along the active fault. The restored results show the downstream paleochannel of the Da River had been abandoned and becomes two small tributaries in opposite flow directions at present due to differential crustal uplift. Also the present crisscross valley at the junction of the Da River and the fault is resulted from the capture by another river which has been also deflected by the neotectonics. Based on our observations on river response, the Dien Bien Phu fault is a sinistral dominant fault with an uplift occurring in its eastern block. Furthermore the active Dien Bien Phu fault does not cut through the Red River northward indicating the western block of the fault can not be regarded as a single rigid block. There should be possible to find NW-SE trending faults paralleling to Red River to accommodate the deformation of the western block of the fault.

Implications of river morphology response to Dien Bien Phu fault in NW Vietnam

NASA Astrophysics Data System (ADS)

Lai, K.; Chen, Y.; Lam, D.

2004-12-01

In northern Vietnam, most rivers are flowing southeastward sub- or parallel to the valley of Red River and characterized by long but narrow catchments. The Dien Bien Phu fault is associated with the most seismically active zone in Vietnam and situated in the potential eastern boundary of the rotating southeastern Tibetan block. It cuts the Da River, the largest tributary of Red River in northwest Vietnam and has distorted the drainage basin resulting in complex river patterns. To assess the river morphology response to active Dien Bien Phu fault, we use 1/50,000 topographic data and ASTER images to map the precise river courses and digital elevation model data of SRTM to retrieve and analyze the river profiles. From the mapping results, the N-S striking fault results in three conspicuous north-trending river valleys coincided with the different fault segments to facilitate the measurement and reconstruction of the offsets along the fault. Further combining the longitudinal profile analysis we obtain ca. 10 km offsets by deflected river as the largest left-lateral displacement recorded along the active fault. The restored results show the downstream paleochannel of the Da River had been abandoned and becomes two small tributaries in opposite flow directions at present due to differential crustal uplift. Also the present crisscross valley at the junction of the Da River and the fault is resulted from the capture by another river which has been also deflected by the neotectonics. Based on our observations on river response, the Dien Bien Phu fault is a sinistral dominant fault with an uplift occurring in its eastern block. Furthermore the active Dien Bien Phu fault does not cut through the Red River northward indicating the western block of the fault can not be regarded as a single rigid block. There should be possible to find NW-SE trending faults paralleling to Red River to accommodate the deformation of the western block of the fault.

Cold seeps and splay faults on Nankai margin

NASA Astrophysics Data System (ADS)

Henry, P.; Ashi, J.; Tsunogai, U.; Toki, T.; Kuramoto, S.; Kinoshita, M.; Lallemant, S. J.

2003-04-01

Cold seeps (bacterial mats, specific fauna, authigenic carbonates) are common on the Nankai margin and considered as evidence for seepage of methane bearing fluids. Camera and submersible surveys performed over the years have shown that cold seeps are generally associated with active faults. One question is whether part of the fluids expelled originate from the seismogenic zone and migrate along splay faults to the seafloor. The localisation of most cold seeps on the hanging wall of major thrusts may, however, be interpreted in various ways: (a) footwall compaction and diffuse flow (b) fluid channelling along the fault zone at depths and diffuse flow near the seafloor (c) erosion and channelling along permeable strata. In 2002, new observations and sampling were performed with submersible and ROV (1) on major thrusts along the boundary between the Kumano forearc basin domain and the accretionary wedge domain, (2) on a fault affecting the forearc (Kodaiba fault), (3) on mud volcanoes in the Kumano basin. In area (1) tsunami and seismic inversions indicate that the targeted thrusts are in the slip zone of the To-Nankai 1944 earthquakes. In this area, the largest seep zone, continuous over at least 2 km, coincides with the termination of a thrust trace, indicating local fluid channelling along the edge of the fault zone. Kodaiba fault is part of another splay fault system, which has both thrusting and strike-slip components and terminates westward into an en-echelon fold system. Strong seepage activity with abundant carbonates was found on a fold at the fault termination. One mud volcano, rooted in one of the en-echelon fold, has exceptionally high seepage activity compared with the others and thick carbonate crusts. These observations suggest that fluid expulsion along fault zones is most active at fault terminations and may be enhanced during fault initiation. Preliminary geochemical results indicate signatures differ between seep sites and suggests that the two fault systems tap in different sources.

Active faults and minor plates in NE Asia

NASA Astrophysics Data System (ADS)

Kozhurin, Andrey I.; Zelenin, Egor A.

2014-05-01

Stated nearly 40 yr ago the uncertainty with plate boundaries location in NE Asia (Chapman, Solomon, 1976) still remains unresolved. Based on the prepositions that a plate boundary must, first, reveal itself in linear sets of active structures, and, second, be continuous and closed, we have undertaken interpretation of medium-resolution KH-9 Hexagon satellite imageries, mostly in stereoscopic regime, for nearly the entire region of NE Asia. Main findings are as follows. There are two major active fault zones in the region north of the Bering Sea. One of them, the Khatyrka-Vyvenka zone, stretches NE to ENE skirting the Bering Sea from the Kamchatka isthmus to the Navarin Cape. Judging by the kinematics of the Olyutorsky 2006 earthquake fault, the fault zones move both right-laterally and reversely. The second active fault zone, the Lankovaya-Omolon zone, starts close to the NE margin of the Okhotsk Sea and extends NE up to nearly the margin of the Chukcha Sea. The fault zone is mostly right-lateral, with topographically expressed cumulative horizontal offsets amounting to 2.5-2.6 km. There may be a third NE-SW zone between the major two coinciding with the Penzhina Range as several active faults found in the southern termination of the Range indicate. The two active fault zones divide the NE Asia area into two large domains, which both could be parts of the Bering Sea plate internally broken and with uncertain western limit. Another variant implies the Khatyrka-Vyvenka zone as the Bering Sea plate northern limit, and the Lankovaya-Omolon zone as separating an additional minor plate from the North-American plate. The choice is actually not crucial, and more important is that both variants leave the question of where the Bering Sea plate boundary is in Alaska. The Lankovaya-Omolon zone stretches just across the proposed northern boundary of the Okhorsk Sea plate. NW of the zone, there is a prominent left-lateral Ulakhan fault, which is commonly interpreted to be a portion of the plate northern boundary. With this, we have discovered no active faults or fault zones of the Ulakhan fault strike, which could be the portion of the boundary between the Lankovaya-Omolon zone and either the western margin of the Komandor basin or the westernmost Aleutians. We conclude that there is a certain disagreement between active faulting pattern and plate models for NE Asia, relating to the extent of the plates and missing portions of the plate boundaries. The research was supported by grant # 110500136-a from the Russian Foundation for Basic Research.

Quantitative Assessment of Potentially Active Faults in Oklahoma Utilizing Detailed Information on In Situ Stress Orientation and Relative Magnitude

NASA Astrophysics Data System (ADS)

Walsh, R.; Zoback, M. D.

2015-12-01

Over the past six years, the earthquake rate in the central and eastern U.S. has increased markedly, and is related to fluid injection. Nowhere has seismicity increased more than in Oklahoma, where large volumes of saline pore water are co-produced with oil and gas, then injected into deeper sedimentary formations. These deeper formations appear to be in hydraulic communication with potentially active faults in crystalline basement, where nearly all the earthquakes are occurring. Although the majority of the recent earthquakes have posed little danger to the public, the possibility of triggering damaging earthquakes on potentially active basement faults cannot be discounted. To understand probability of slip on a given fault, we invert for stresses from the hundreds of M4+ events in Oklahoma for which moment tensors have been made. We then resolve these stresses, while incorporating uncertainties, on the faults from the preliminary Oklahoma fault map. The result is a probabilistic understanding of which faults are most likely active and best avoided.

Late Quaternary strike-slip along the Taohuala Shan-Ayouqi fault zone and its tectonic implications in the Hexi Corridor and the southern Gobi Alashan, China

NASA Astrophysics Data System (ADS)

Yu, Jing-xing; Zheng, Wen-jun; Zhang, Pei-zhen; Lei, Qi-yun; Wang, Xu-long; Wang, Wei-tao; Li, Xin-nan; Zhang, Ning

2017-11-01

The Hexi Corridor and the southern Gobi Alashan are composed of discontinuous a set of active faults with various strikes and slip motions that are located to the north of the northern Tibetan Plateau. Despite growing understanding of the geometry and kinematics of these active faults, the late Quaternary deformation pattern in the Hexi Corridor and the southern Gobi Alashan remains controversial. The active E-W trending Taohuala Shan-Ayouqi fault zone is located in the southern Gobi Alashan. Study of the geometry and nature of slip along this fault zone holds crucial value for better understanding the regional deformation pattern. Field investigations combined with high-resolution imagery show that the Taohuala Shan fault and the E-W trending faults within the Ayouqi fault zone (F2 and F5) are left-lateral strike-slip faults, whereas the NW or WNW-trending faults within the Ayouqi fault zone (F1 and F3) are reverse faults. We collected Optically Stimulated Luminescence (OSL) and cosmogenic exposure age dating samples from offset alluvial fan surfaces, and estimated a vertical slip rate of 0.1-0.3 mm/yr, and a strike-slip rate of 0.14-0.93 mm/yr for the Taohuala Shan fault. Strata revealed in a trench excavated across the major fault (F5) in the Ayouqi fault zone and OSL dating results indicate that the most recent earthquake occurred between ca. 11.05 ± 0.52 ka and ca. 4.06 ± 0.29 ka. The geometry and kinematics of the Taohuala Shan-Ayouqi fault zone enable us to build a deformation pattern for the entire Hexi Corridor and the southern Gobi Alashan, which suggest that this region experiences northeastward oblique extrusion of the northern Tibetan Plateau. These left-lateral strike-slip faults in the region are driven by oblique compression but not associated with the northeastward extension of the Altyn Tagh fault.

Active tectonics of the northern Mojave Desert: The 2017 Desert Symposium field trip road log

USGS Publications Warehouse

Miller, David; Reynolds, R.E.; Phelps, Geoffrey; Honke, Jeff; Cyr, Andrew J.; Buesch, David C.; Schmidt, Kevin M.; Losson, G.

2017-01-01

The 2017 Desert Symposium field trip will highlight recent work by the U.S. Geological Survey geologists and geophysicists, who have been mapping young sediment and geomorphology associated with active tectonic features in the least well-known part of the eastern California Shear Zone (ECSZ). This area, stretching from Barstow eastward in a giant arc to end near the Granite Mountains on the south and the Avawatz Mountains on the north (Fig. 1-1), encompasses the two major structural components of the ECSZ—east-striking sinistral faults and northwest-striking dextral faults—as well as reverseoblique and normal-oblique faults that are associated with topographic highs and sags, respectively. In addition, folds and stepovers (both restraining stepovers that form pop-up structures and releasing stepovers that create narrow basins) have been identified. The ECSZ is a segment in the ‘soft’ distributed deformation of the North American plate east of the San Andreas fault (Fig. 1-1), where it takes up approximately 20-25% of plate motion in a broad zone of right-lateral shear (Sauber et al., 1994) The ECSZ (sensu strictu) begins in the Joshua Tree area and passes north through the Mojave Desert, past the Owens Valley-to-Death Valley swath and northward, where it is termed the Walker Lane. It has been defined as the locus of active faulting (Dokka and Travis, 1990), but when the full history from about 10 Ma forward is considered, it lies in a broader zone of right shear that passes westward in the Mojave Desert to the San Andreas fault (Mojave strike-slip province of Miller and Yount, 2002) and passes eastward to the Nevada state line or beyond (Miller, this volume).We will visit several accessible highlights for newly studied faults, signs of young deformation, and packages of syntectonic sediments. These pieces of a complex active tectonic puzzle have yielded some answers to longstanding questions such as: How is fault slip transfer in this area accommodated between northwest-striking dextral faults and eaststriking sinistral faults?How is active deformation on the Ludlow fault transferred northward, presumably to connect to the southern Death Valley fault zone?When were faults in this area of the central Mojave Desert initiated?Are faults in this area more or less active than faults in the ECSZ to the west?What is the role of NNW-striking faults and when did they form?How has fault slip changed over time? Locations and fault names are provided in figure 1-2. Important turns and locations are identified with locations in the projection: UTM, zone 11; datum NAD 83: (578530 3917335).

Project DAFNE - Drilling Active Faults in Northern Europe

NASA Astrophysics Data System (ADS)

Kukkonen, I. T.; Ask, M. S. V.; Olesen, O.

2012-04-01

We are currently developing a new ICDP project 'Drillling Active Faults in Northern Europe' (DAFNE) which aims at investigating, via scientific drilling, the tectonic and structural characteristics of postglacial (PG) faults in northern Fennoscandia, including their hydrogeology and associated deep biosphere [1, 2]. During the last stages of the Weichselian glaciation (ca. 9,000 - 15,000 years B.P.), reduced ice load and glacially affected stress field resulted in active faulting in Fennoscandia with fault scarps up to 160 km long and 30 m high. These postglacial (PG) faults are usually SE dipping, SW-NE oriented thrusts, and represent reactivated, pre-existing crustal discontinuities. Postglacial faulting indicates that the glacio-isostatic compensation is not only a gradual viscoelastic phenomenon, but includes also unexpected violent earthquakes, suggestively larger than other known earthquakes in stable continental regions. The research is anticipated to advance science in neotectonics, hydrogeology and deep biosphere studies, and provide important information for nuclear waste and CO2 disposal, petroleum exploration on the Norwegian continental shelf and studies of mineral resources in PG fault areas. We expect that multidisciplinary research applying shallow and deep drilling of postglacial faults would provide significant scientific results through generating new data and models, namely: (1) Understanding PG fault genesis and controls of their locations; (2) Deep structure and depth extent of PG faults; (3) Textural, mineralogical and physical alteration of rocks in the PG faults; (4) State of stress and estimates of paleostress of PG faults; (5) Hydrogeology, hydrochemistry and hydraulic properties of PG faults; (6) Dating of tectonic reactivation(s) and temporal evolution of tectonic systems hosting PG faults; (7) Existence/non-existence of deep biosphere in PG faults; (8) Data useful for planning radioactive waste disposal in crystalline bedrock; (9) Data on rock stress changes in the periphery of the inland ice; (10) Stress pattern along the Norwegian continental margin in relation to the bending spreading ridge and Plio-Pleistocene erosion, uplift and sedimentation with implications for fluid migration and sealing properties of petroleum reservoirs. (11) Data useful in predicting future seismic activity in areas of current deglaciation due to ongoing climatic warming.

The Quaternary thrust system of the northern Alaska Range

USGS Publications Warehouse

Bemis, Sean P.; Carver, Gary A.; Koehler, Richard D.

2012-01-01

The framework of Quaternary faults in Alaska remains poorly constrained. Recent studies in the Alaska Range north of the Denali fault add significantly to the recognition of Quaternary deformation in this active orogen. Faults and folds active during the Quaternary occur over a length of ∼500 km along the northern flank of the Alaska Range, extending from Mount McKinley (Denali) eastward to the Tok River valley. These faults exist as a continuous system of active structures, but we divide the system into four regions based on east-west changes in structural style. At the western end, the Kantishna Hills have only two known faults but the highest rate of shallow crustal seismicity. The western northern foothills fold-thrust belt consists of a 50-km-wide zone of subparallel thrust and reverse faults. This broad zone of deformation narrows to the east in a transition zone where the range-bounding fault of the western northern foothills fold-thrust belt terminates and displacement occurs on thrust and/or reverse faults closer to the Denali fault. The eastern northern foothills fold-thrust belt is characterized by ∼40-km-long thrust fault segments separated across left-steps by NNE-trending left-lateral faults. Altogether, these faults accommodate much of the topographic growth of the northern flank of the Alaska Range.Recognition of this thrust fault system represents a significant concern in addition to the Denali fault for infrastructure adjacent to and transecting the Alaska Range. Although additional work is required to characterize these faults sufficiently for seismic hazard analysis, the regional extent and structural character should require the consideration of the northern Alaska Range thrust system in regional tectonic models.

Stimulus familiarity modulates functional connectivity of the perirhinal cortex and anterior hippocampus during visual discrimination of faces and objects

PubMed Central

McLelland, Victoria C.; Chan, David; Ferber, Susanne; Barense, Morgan D.

2014-01-01

Recent research suggests that the medial temporal lobe (MTL) is involved in perception as well as in declarative memory. Amnesic patients with focal MTL lesions and semantic dementia patients showed perceptual deficits when discriminating faces and objects. Interestingly, these two patient groups showed different profiles of impairment for familiar and unfamiliar stimuli. For MTL amnesics, the use of familiar relative to unfamiliar stimuli improved discrimination performance. By contrast, patients with semantic dementia—a neurodegenerative condition associated with anterolateral temporal lobe damage—showed no such facilitation from familiar stimuli. Given that the two patient groups had highly overlapping patterns of damage to the perirhinal cortex, hippocampus, and temporal pole, the neuroanatomical substrates underlying their performance discrepancy were unclear. Here, we addressed this question with a multivariate reanalysis of the data presented by Barense et al. (2011), using functional connectivity to examine how stimulus familiarity affected the broader networks with which the perirhinal cortex, hippocampus, and temporal poles interact. In this study, healthy participants were scanned while they performed an odd-one-out perceptual task involving familiar and novel faces or objects. Seed-based analyses revealed that functional connectivity of the right perirhinal cortex and right anterior hippocampus was modulated by the degree of stimulus familiarity. For familiar relative to unfamiliar faces and objects, both right perirhinal cortex and right anterior hippocampus showed enhanced functional correlations with anterior/lateral temporal cortex, temporal pole, and medial/lateral parietal cortex. These findings suggest that in order to benefit from stimulus familiarity, it is necessary to engage not only the perirhinal cortex and hippocampus, but also a network of regions known to represent semantic information. PMID:24624075

Consumer acceptability and understanding of front-of-pack nutrition labels.

PubMed

Mejean, C; Macouillard, P; Péneau, S; Hercberg, S; Castetbon, K

2013-10-01

Front-of-pack (FOP) nutrition labelling has been proposed as a tool for helping consumers make healthy choices. Before determining its effects on consumer behaviour, factors involved in its use must be elucidated, i.e. understanding and acceptability on the part of the consumer. Among five FOP labels, we sought to determine which formats were most easily understood and accepted by a large sample of adults. Among 39 370 adults who participated in the French Nutrinet-Santé cohort study, understanding and indicators of acceptability (attitude, liking, visual attractiveness and perceived cognitive workload) were measured for five FOP labels: The currently used 'multiple traffic lights' (MTL) and 'simple traffic lights' (STL), and the 'colour range' logo (CR), the 'green tick' and the PNNS logo. We investigated the contribution of the different elements to consumer perception of FOP labels using multiple correspondence analyses. Over half of the sample population showed a high level of understanding and perceived no discomfort in terms of the different logos. Label formats were positioned along an acceptability gradient ranging from acceptance to rejection, consisting of 'liking', 'attractiveness' and indicators of perceived cognitive workload. MTL was significantly more often liked and was viewed as reliable and informative. MTL, STL and the green tick performed better than the CR and PNNS logos in terms of ease of identification and comprehension. CR was clearly the least appreciated and it had the most complex format. Consumers prefer FOP labels which give complete, reliable and simplified information on the nutrient quality of foods. © 2013 The Authors Journal of Human Nutrition and Dietetics © 2013 The British Dietetic Association Ltd.

Gait Deviations in Children With Osteogenesis Imperfecta Type I.

PubMed

Garman, Christina R; Graf, Adam; Krzak, Joseph; Caudill, Angela; Smith, Peter; Harris, Gerald

2017-08-02

Osteogenesis imperfecta (OI) is a congenital connective tissue disorder often characterized by orthopaedic complications that impact normal gait. As such, mobility is of particular interest in the OI population as it is associated with multiple aspects of participation and quality of life. The purpose of the current study was to identify and describe common gait deviations in a large sample of individuals with type I OI and speculate the etiology with a goal of improving function. Gait analysis was performed on 44 subjects with type I (11.7±3.08 y old) and 30 typically developing controls (9.54±3.1 y old ). Spatial temporal, kinematic, and kinetic gait data were calculated from the Vicon Plug-in-Gait Model. Musculoskeletal modeling of the muscle tendon lengths (MTL) was done in OpenSim 3.3 to evaluate the MTL of the gastrocnemius and gluteus maximus. The gait deviation index, a dimensionless parameter that evaluates the deviation of 9 kinematic gait parameters from a control database, was also calculated. Walking speed, single support time, stride, and step length were lower and double support time was higher in the OI group. The gait deviation index score was lower and external hip rotation angle was higher in the OI group. Peak hip flexor, knee extensor and ankle plantarflexor moments, and power generation at the ankle were lower in the OI group. MTL analysis revealed no significant length discrepancies between the OI group and the typically developing group. Together, these findings provide a comprehensive description of gait characteristics among a group of individuals with type I OI. Such data inform clinicians about specific gait deviations in this population allowing clinicians to recommend more focused interventions. Level III-case-control study.

The life stories of adults with amnesia: Insights into the contribution of the medial temporal lobes to the organization of autobiographical memory.

PubMed

Grilli, Matthew D; Wank, Aubrey A; Verfaellie, Mieke

2018-02-01

Autobiographical memories are not stored in isolation but rather are organized into life chapters, higher-order knowledge structures that represent major themes conveying the arc of one's life. Neuropsychological studies have revealed that both episodic memory and some aspects of personal semantic memory are impaired in adults with medial temporal lobe (MTL) damage. However, whether such impairment compromises the retrieval and formation of life chapters is unknown. Therefore, we had 10 adults with MTL amnesia and 20 control participants narrate their life stories, and we extracted life chapters from these narratives using a novel scoring protocol. For the retrograde and anterograde time period separately, we evaluated the number of life chapters and assessed their quality, as indexed by measures of complexity and richness. Additionally, to investigate the idea that formation of life chapters occurs on a protracted time scale, we separated the amnesic participants into an early-life and a later-life onset subgroup. Results revealed that early-onset, but not later-onset, amnesic participants generated fewer retrograde life chapters than controls. The higher-order temporal relation among retrograde chapters, but not their thematic relation or the richness of individual life chapters, was impaired in both amnesic subgroups. The amnesic participants also generated fewer anterograde life chapters than controls, and the richness of their anterograde chapters was reduced in terms of content, but not self-reflection. Findings suggest that the organization of autobiographical content into life chapters is a protracted process that depends on the MTL, as does retrieval of higher order temporal relations among life chapters. Copyright © 2017 Elsevier Ltd. All rights reserved.

Accounting for the Confound of Meninges in Segmenting Entorhinal and Perirhinal Cortices in T1-Weighted MRI.

PubMed

Xie, Long; Wisse, Laura E M; Das, Sandhitsu R; Wang, Hongzhi; Wolk, David A; Manjón, Jose V; Yushkevich, Paul A

2016-10-01

Quantification of medial temporal lobe (MTL) cortices, including entorhinal cortex (ERC) and perirhinal cortex (PRC), from in vivo MRI is desirable for studying the human memory system as well as in early diagnosis and monitoring of Alzheimer's disease. However, ERC and PRC are commonly over-segmented in T1-weighted (T1w) MRI because of the adjacent meninges that have similar intensity to gray matter in T1 contrast. This introduces errors in the quantification and could potentially confound imaging studies of ERC/PRC. In this paper, we propose to segment MTL cortices along with the adjacent meninges in T1w MRI using an established multi-atlas segmentation framework together with super-resolution technique. Experimental results comparing the proposed pipeline with existing pipelines support the notion that a large portion of meninges is segmented as gray matter by existing algorithms but not by our algorithm. Cross-validation experiments demonstrate promising segmentation accuracy. Further, agreement between the volume and thickness measures from the proposed pipeline and those from the manual segmentations increase dramatically as a result of accounting for the confound of meninges. Evaluated in the context of group discrimination between patients with amnestic mild cognitive impairment and normal controls, the proposed pipeline generates more biologically plausible results and improves the statistical power in discriminating groups in absolute terms comparing to other techniques using T1w MRI. Although the performance of the proposed pipeline is inferior to that using T2-weighted MRI, which is optimized to image MTL sub-structures, the proposed pipeline could still provide important utilities in analyzing many existing large datasets that only have T1w MRI available.

Manual Planimetry of the Medial Temporal Lobe Versus Automated Volumetry of the Hippocampus in the Diagnosis of Alzheimer's Disease.

PubMed

Menéndez González, Manuel; Suárez-Sanmartin, Esther; García, Ciara; Martínez-Camblor, Pablo; Westman, Eric; Simmons, Andy

2016-03-26

Though a disproportionate rate of atrophy in the medial temporal lobe (MTA) represents a reliable marker of Alzheimer's disease (AD) pathology, measurement of the MTA is not currently widely used in daily clinical practice. This is mainly because the methods available to date are sophisticated and difficult to implement in clinical practice (volumetric methods), are poorly explored (linear and planimetric methods), or lack objectivity (visual rating). Here, we aimed to compare the results of a manual planimetric measure (the yearly rate of absolute atrophy of the medial temporal lobe, 2D-yrA-MTL) with the results of an automated volumetric measure (the yearly rate of atrophy of the hippocampus, 3D-yrA-H). A series of 1.5T MRI studies on 290 subjects in the age range of 65-85 years, including patients with AD (n = 100), mild cognitive impairment (MCI) (n = 100), and matched controls (n = 90) from the AddNeuroMed study, were examined by two independent subgroups of researchers: one in charge of volumetric measures and the other in charge of planimetric measures. The means of both methods were significantly different between AD and the other two diagnostic groups. In the differential diagnosis of AD against controls, 3D-yrA-H performed significantly better than 2D-yrA-MTL while differences were not statistically significant in the differential diagnosis of AD against MCI. Automated volumetry of the hippocampus is superior to manual planimetry of the MTL in the diagnosis of AD. Nevertheless, the 2D-yrAMTL is a simpler method that could be easily implemented in clinical practice when volumetry is not available.

Geometry and kinematics of adhesive wear in brittle strike-slip fault zones

NASA Astrophysics Data System (ADS)

Swanson, Mark T.

2005-05-01

Detailed outcrop surface mapping in Late Paleozoic cataclastic strike-slip faults of coastal Maine shows that asymmetric sidewall ripouts, 0.1-200 m in length, are a significant component of many mapped faults and an important wall rock deformation mechanism during faulting. The geometry of these structures ranges from simple lenses to elongate slabs cut out of the sidewalls of strike-slip faults by a lateral jump of the active zone of slip during adhesion along a section of the main fault. The new irregular trace of the active fault after this jump creates an indenting asperity that is forced to plow through the adjoining wall rock during continued adhesion or be cut off by renewed motion along the main section of the fault. Ripout translation during adhesion sets up the structural asymmetry with trailing extensional and leading contractional ends to the ripout block. The inactive section of the main fault trace at the trailing end can develop a 'sag' or 'half-graben' type geometry due to block movement along the scallop-shaped connecting ramp to the flanking ripout fault. Leading contractional ramps can develop 'thrust' type imbrication and forces the 'humpback' geometry to the ripout slab due to distortion of the inactive main fault surface by ripout translation. Similar asymmetric ripout geometries are recognized in many other major crustal scale strike-slip fault zones worldwide. Ripout structures in the 5-500 km length range can be found on the Atacama fault system of northern Chile, the Qujiang and Xiaojiang fault zones in western China, the Yalakom-Hozameen fault zone in British Columbia and the San Andreas fault system in southern California. For active crustal-scale faults the surface expression of ripout translation includes a coupled system of extensional trailing ramps as normal oblique-slip faults with pull-apart basin sedimentation and contractional leading ramps as oblique thrust or high angle reverse faults with associated uplift and erosion. The sidewall ripout model, as a mechanism for adhesive wear during fault zone deformation, can be useful in studies of fault zone geometry, kinematics and evolution from outcrop- to crustal-scales.

Active transfer fault zone linking a segmented extensional system (Betics, southern Spain): Insight into heterogeneous extension driven by edge delamination

NASA Astrophysics Data System (ADS)

Martínez-Martínez, José Miguel; Booth-Rea, Guillermo; Azañón, José Miguel; Torcal, Federico

2006-08-01

Pliocene and Quaternary tectonic structures mainly consisting of segmented northwest-southeast normal faults, and associated seismicity in the central Betics do not agree with the transpressive tectonic nature of the Africa-Eurasia plate boundary in the Ibero-Maghrebian region. Active extensional deformation here is heterogeneous, individual segmented normal faults being linked by relay ramps and transfer faults, including oblique-slip and both dextral and sinistral strike-slip faults. Normal faults extend the hanging wall of an extensional detachment that is the active segment of a complex system of successive WSW-directed extensional detachments which have thinned the Betic upper crust since middle Miocene. Two areas, which are connected by an active 40-km long dextral strike-slip transfer fault zone, concentrate present-day extension. Both the seismicity distribution and focal mechanisms agree with the position and regime of the observed faults. The activity of the transfer zone during middle Miocene to present implies a mode of extension which must have remained substantially the same over the entire period. Thus, the mechanisms driving extension should still be operating. Both the westward migration of the extensional loci and the high asymmetry of the extensional systems can be related to edge delamination below the south Iberian margin coupled with roll-back under the Alborán Sea; involving the asymmetric westward inflow of asthenospheric material under the margins.

Criteria for Seismic Splay Fault Activation During Subduction Earthquakes

NASA Astrophysics Data System (ADS)

Dedontney, N.; Templeton, E.; Bhat, H.; Dmowska, R.; Rice, J. R.

2008-12-01

As sediment is added to the accretionary prism or removed from the forearc, the material overlying the plate interface must deform to maintain a wedge structure. One of the ways this internal deformation is achieved is by slip on splay faults branching from the main detachment, which are possibly activated as part of a major seismic event. As a rupture propagates updip along the plate interface, it will reach a series of junctions between the shallowly dipping detachment and more steeply dipping splay faults. The amount and distribution of slip on these splay faults and the detachment determines the seafloor deformation and the tsunami waveform. Numerical studies by Kame et al. [JGR, 2003] of fault branching during dynamic slip-weakening rupture in 2D plane strain showed that branch activation depends on the initial stress state, rupture velocity at the branching junction, and branch angle. They found that for a constant initial stress state, with the maximum principal stress at shallow angles to the main fault, branch activation is favored on the compressional side of the fault for a range of branch angles. By extending the part of their work on modeling the branching behavior in the context of subduction zones, where critical taper wedge concepts suggest the angle that the principal stress makes with the main fault is shallow, but not horizontal, we hope to better understand the conditions for splay fault activation and the criteria for significant moment release on the splay. Our aim is to determine the range of initial stresses and relative frictional strengths of the detachment and splay fault that would result in seismic splay fault activation. In aid of that, we conduct similar dynamic rupture analyses to those of Kame et al., but use explicit finite element methods, and take fuller account of overall structure of the zone (rather than focusing just on the branching junction). Critical taper theory requires that the basal fault be weaker than the overlying material, so we build on previous work by incorporating the effect of strength contrasts between the basal and splay faults. The relative weakness of the basal fault is often attributed to high pore pressures, which lowers the effective normal stress and brings the basal fault closer to failure. We vary the initial stress state, while maintaining a constant principal stress orientation, to see how the closeness to failure affects the branching behavior for a variety of branch step-up angles.

Faults on Skylab imagery of the Salton Trough area, Southern California

NASA Technical Reports Server (NTRS)

Merifield, P. M.; Lamar, D. L. (Principal Investigator)

1975-01-01

The author has identified the following significant results. Large segments of the major high angle faults in the Salton Trough area are readily identifiable in Skylab images. Along active faults, distinctive topographic features such as scarps and offset drainage, and vegetation differences due to ground water blockage in alluvium are visible. Other fault-controlled features along inactive as well as active faults visible in Skylab photography include straight mountain fronts, linear valleys, and lithologic differences producing contrasting tone, color or texture. A northwestern extension of a fault in the San Andreas set, is postulated by the regional alignment of possible fault-controlled features. The suspected fault is covered by Holocene deposits, principally windblown sand. A northwest trending tonal change in cultivated fields across Mexicali Valley is visible on Skylab photos. Surface evidence for faulting was not observed; however, the linear may be caused by differences in soil conditions along an extension of a segment of the San Jacinto fault zone. No evidence of faulting could be found along linears which appear as possible extensions of the Substation and Victory Pass faults, demonstrating that the interpretation of linears as faults in small scale photography must be corroborated by field investigations.

Orogen-scale uplift in the central Italian Apennines drives episodic behaviour of earthquake faults

PubMed Central

Cowie, P. A.; Phillips, R. J.; Roberts, G. P.; McCaffrey, K.; Zijerveld, L. J. J.; Gregory, L. C.; Faure Walker, J.; Wedmore, L. N. J.; Dunai, T. J.; Binnie, S. A.; Freeman, S. P. H. T.; Wilcken, K.; Shanks, R. P.; Huismans, R. S.; Papanikolaou, I.; Michetti, A. M.; Wilkinson, M.

2017-01-01

Many areas of the Earth’s crust deform by distributed extensional faulting and complex fault interactions are often observed. Geodetic data generally indicate a simpler picture of continuum deformation over decades but relating this behaviour to earthquake occurrence over centuries, given numerous potentially active faults, remains a global problem in hazard assessment. We address this challenge for an array of seismogenic faults in the central Italian Apennines, where crustal extension and devastating earthquakes occur in response to regional surface uplift. We constrain fault slip-rates since ~18 ka using variations in cosmogenic 36Cl measured on bedrock scarps, mapped using LiDAR and ground penetrating radar, and compare these rates to those inferred from geodesy. The 36Cl data reveal that individual faults typically accumulate meters of displacement relatively rapidly over several thousand years, separated by similar length time intervals when slip-rates are much lower, and activity shifts between faults across strike. Our rates agree with continuum deformation rates when averaged over long spatial or temporal scales (104 yr; 102 km) but over shorter timescales most of the deformation may be accommodated by <30% of the across-strike fault array. We attribute the shifts in activity to temporal variations in the mechanical work of faulting. PMID:28322311

Orogen-scale uplift in the central Italian Apennines drives episodic behaviour of earthquake faults.

PubMed

Cowie, P A; Phillips, R J; Roberts, G P; McCaffrey, K; Zijerveld, L J J; Gregory, L C; Faure Walker, J; Wedmore, L N J; Dunai, T J; Binnie, S A; Freeman, S P H T; Wilcken, K; Shanks, R P; Huismans, R S; Papanikolaou, I; Michetti, A M; Wilkinson, M

2017-03-21

Many areas of the Earth's crust deform by distributed extensional faulting and complex fault interactions are often observed. Geodetic data generally indicate a simpler picture of continuum deformation over decades but relating this behaviour to earthquake occurrence over centuries, given numerous potentially active faults, remains a global problem in hazard assessment. We address this challenge for an array of seismogenic faults in the central Italian Apennines, where crustal extension and devastating earthquakes occur in response to regional surface uplift. We constrain fault slip-rates since ~18 ka using variations in cosmogenic 36 Cl measured on bedrock scarps, mapped using LiDAR and ground penetrating radar, and compare these rates to those inferred from geodesy. The 36 Cl data reveal that individual faults typically accumulate meters of displacement relatively rapidly over several thousand years, separated by similar length time intervals when slip-rates are much lower, and activity shifts between faults across strike. Our rates agree with continuum deformation rates when averaged over long spatial or temporal scales (10 4  yr; 10 2  km) but over shorter timescales most of the deformation may be accommodated by <30% of the across-strike fault array. We attribute the shifts in activity to temporal variations in the mechanical work of faulting.

Assessing active faulting by hydrogeological modeling and superconducting gravimetry: A case study for Hsinchu Fault, Taiwan

NASA Astrophysics Data System (ADS)

Lien, Tzuyi; Cheng, Ching-Chung; Hwang, Cheinway; Crossley, David

2014-09-01

We develop a new hydrology and gravimetry-based method to assess whether or not a local fault may be active. We take advantage of an existing superconducting gravimeter (SG) station and a comprehensive groundwater network in Hsinchu to apply the method to the Hsinchu Fault (HF) across the Hsinchu Science Park, whose industrial output accounts for 10% of Taiwan's gross domestic product. The HF is suspected to pose seismic hazards to the park, but its existence and structure are not clear. The a priori geometry of the HF is translated into boundary conditions imposed in the hydrodynamic model. By varying the fault's location, depth, and including a secondary wrench fault, we construct five hydrodynamic models to estimate groundwater variations, which are evaluated by comparing groundwater levels and SG observations. The results reveal that the HF contains a low hydraulic conductivity core and significantly impacts groundwater flows in the aquifers. Imposing the fault boundary conditions leads to about 63-77% reduction in the differences between modeled and observed values (both water level and gravity). The test with fault depth shows that the HF's most recent slip occurred in the beginning of Holocene, supplying a necessary (but not sufficient) condition that the HF is currently active. A portable SG can act as a virtual borehole well for model assessment at critical locations of a suspected active fault.

Spatial Distribution of the Coefficient of Variation and Bayesian Forecast for the Paleo-Earthquakes in Japan

NASA Astrophysics Data System (ADS)

Nomura, Shunichi; Ogata, Yosihiko

2016-04-01

We propose a Bayesian method of probability forecasting for recurrent earthquakes of inland active faults in Japan. Renewal processes with the Brownian Passage Time (BPT) distribution are applied for over a half of active faults in Japan by the Headquarters for Earthquake Research Promotion (HERP) of Japan. Long-term forecast with the BPT distribution needs two parameters; the mean and coefficient of variation (COV) for recurrence intervals. The HERP applies a common COV parameter for all of these faults because most of them have very few specified paleoseismic events, which is not enough to estimate reliable COV values for respective faults. However, different COV estimates are proposed for the same paleoseismic catalog by some related works. It can make critical difference in forecast to apply different COV estimates and so COV should be carefully selected for individual faults. Recurrence intervals on a fault are, on the average, determined by the long-term slip rate caused by the tectonic motion but fluctuated by nearby seismicities which influence surrounding stress field. The COVs of recurrence intervals depend on such stress perturbation and so have spatial trends due to the heterogeneity of tectonic motion and seismicity. Thus we introduce a spatial structure on its COV parameter by Bayesian modeling with a Gaussian process prior. The COVs on active faults are correlated and take similar values for closely located faults. It is found that the spatial trends in the estimated COV values coincide with the density of active faults in Japan. We also show Bayesian forecasts by the proposed model using Markov chain Monte Carlo method. Our forecasts are different from HERP's forecast especially on the active faults where HERP's forecasts are very high or low.

The Effects of Acutely Administered 3,4-Methylenedioxymethamphetamine on Spontaneous Brain Function in Healthy Volunteers Measured with Arterial Spin Labeling and Blood Oxygen Level–Dependent Resting State Functional Connectivity

PubMed Central

Carhart-Harris, Robin L.; Murphy, Kevin; Leech, Robert; Erritzoe, David; Wall, Matthew B.; Ferguson, Bart; Williams, Luke T.J.; Roseman, Leor; Brugger, Stefan; De Meer, Ineke; Tanner, Mark; Tyacke, Robin; Wolff, Kim; Sethi, Ajun; Bloomfield, Michael A.P.; Williams, Tim M.; Bolstridge, Mark; Stewart, Lorna; Morgan, Celia; Newbould, Rexford D.; Feilding, Amanda; Curran, H. Val; Nutt, David J.

2015-01-01

Background The compound 3,4-methylenedioxymethamphetamine (MDMA) is a potent monoamine releaser that produces an acute euphoria in most individuals. Methods In a double-blind, placebo-controlled, balanced-order study, MDMA was orally administered to 25 physically and mentally healthy individuals. Arterial spin labeling and seed-based resting state functional connectivity (RSFC) were used to produce spatial maps displaying changes in cerebral blood flow (CBF) and RSFC after MDMA administration. Participants underwent two arterial spin labeling and two blood oxygen level–dependent scans in a 90-minute scan session; MDMA and placebo study days were separated by 1 week. Results Marked increases in positive mood were produced by MDMA. Decreased CBF only was observed after MDMA, and this was localized to the right medial temporal lobe (MTL), thalamus, inferior visual cortex, and the somatosensory cortex. Decreased CBF in the right amygdala and hippocampus correlated with ratings of the intensity of global subjective effects of MDMA. The RSFC results complemented the CBF results, with decreases in RSFC between midline cortical regions, the medial prefrontal cortex, and MTL regions, and increases between the amygdala and hippocampus. There were trend-level correlations between these effects and ratings of intense and positive subjective effects. Conclusions The MTLs appear to be specifically implicated in the mechanism of action of MDMA, but further work is required to elucidate how the drug’s characteristic subjective effects arise from its modulation of spontaneous brain activity. PMID:24495461

A study of microseismicity in northern Baja California, Mexico

NASA Technical Reports Server (NTRS)

Johnson, T. L.; Koczynski, T.; Madrid, J.

1976-01-01

Five microearthquake instruments were operated for 2 months in 1974 in a small mobile array deployed at various sites near the Agua Blanca and San Miguel faults. An 80-km-long section of the San Miguel fault zone is presently active seismically, producing the vast majority of recorded earthquakes. Very low activity was recorded on the Agua Blanca fault. Events were also located near normal faults forming the eastern edge of the Sierra Juarez suggesting that these faults are active. Hypocenters on the San Miguel fault range in depth from 0 to 20 km although two-thirds are in the upper 10 km. A composite focal mechanism showing a mixture of right-lateral and dip slip, east side up, is similar to a solution obtained for the 1956 San Miguel earthquake which proved consistent with observed surface deformation.

The temporal and spatial distribution of upper crustal faulting and magmatism in the south Lake Turkana rift, East Africa

NASA Astrophysics Data System (ADS)

Muirhead, J.; Scholz, C. A.

2017-12-01

During continental breakup extension is accommodated in the upper crust largely through dike intrusion and normal faulting. The Eastern branch of the East African Rift arguably represents the premier example of active continental breakup in the presence magma. Constraining how faulting is distributed in both time and space in these regions is challenging, yet can elucidate how extensional strain localizes within basins as rifting progresses to sea-floor spreading. Studies of active rifts, such as the Turkana Rift, reveal important links between faulting and active magmatic processes. We utilized over 1100 km of high-resolution Compressed High Intensity Radar Pulse (CHIRP) 2D seismic reflection data, integrated with a suite of radiocarbon-dated sediment cores (3 in total), to constrain a 17,000 year history of fault activity in south Lake Turkana. Here, a set of N-S-striking intra-rift faults exhibit time-averaged slip-rates as high as 1.6 mm/yr, with the highest slip-rates occurring along faults within 3 km of the rift axis. Results show that strain has localized into a zone of intra-rift faults along the rift axis, forming an approximately 20 km-wide graben in central parts of the basin. Subsurface structural mapping and fault throw profile analyses reveal increasing basin subsidence and fault-related strain as this faulted graben approaches a volcanic island in the center of the basin (South Island). The long-axis of this island trends north-south, and it contains a number of elongate cones that support recent emplacement of N-S-striking dike intrusions, which parallel recently active intra-rift faults. Overall, these observations suggest strain localization into intra-rift faults in the rift center is likely a product of both volcanic loading and the mechanical and thermal effects of diking along the rift axis. These results support the establishment of magmatic segmentation in southern Lake Turkana, and highlight the importance of magmatism for focusing upper crustal strain as rifts evolve to sea-floor spreading.

Subsurface geometry and evolution of the Seattle fault zone and the Seattle Basin, Washington

USGS Publications Warehouse

ten Brink, Uri S.; Molzer, P.C.; Fisher, M.A.; Blakely, R.J.; Bucknam, R.C.; Parsons, T.; Crosson, R.S.; Creager, K.C.

2002-01-01

The Seattle fault, a large, seismically active, east-west-striking fault zone under Seattle, is the best-studied fault within the tectonically active Puget Lowland in western Washington, yet its subsurface geometry and evolution are not well constrained. We combine several analysis and modeling approaches to study the fault geometry and evolution, including depth-converted, deep-seismic-reflection images, P-wave-velocity field, gravity data, elastic modeling of shoreline uplift from a late Holocene earthquake, and kinematic fault restoration. We propose that the Seattle thrust or reverse fault is accompanied by a shallow, antithetic reverse fault that emerges south of the main fault. The wedge enclosed by the two faults is subject to an enhanced uplift, as indicated by the boxcar shape of the shoreline uplift from the last major earthquake on the fault zone. The Seattle Basin is interpreted as a flexural basin at the footwall of the Seattle fault zone. Basin stratigraphy and the regional tectonic history lead us to suggest that the Seattle fault zone initiated as a reverse fault during the middle Miocene, concurrently with changes in the regional stress field, to absorb some of the north-south shortening of the Cascadia forearc. Kingston Arch, 30 km north of the Seattle fault zone, is interpreted as a more recent disruption arising within the basin, probably due to the development of a blind reverse fault.

Active tectonics and strain partitioning along dextral fault system in Central Iran: Analysis of geomorphological observations and geophysical data in the Kashan region

NASA Astrophysics Data System (ADS)

Jamali, Farshad; Hessami, Khaled; Ghorashi, Manoochehr

2011-03-01

This paper uses high-resolution images and field investigations, in conjunction with seismic reflection data, to constrain active structural deformation in the Kashan region of Central Iran. Offset stream beds and Qanats indicate right-lateral strike slip motion at a rate of about 2 mm/yr along the NW-SE trending Qom-Zefreh fault zone which has long been recognized as one of the major faults in Central Iran. However, the pattern of drainage systems across the active growing folds including deep incision of stream beds and deflected streams indicate uplift at depth on thrust faults dipping SW beneath the anticlines. Therefore, our studies in the Kashan region indicate that deformation occurs within Central Iran which is often considered to behave as a non-deforming block within the Arabia-Eurasia collision zone. The fact that the active Qom-Zefreh strike-slip fault runs parallel to the active folds, which overlie blind thrust faults, suggests that oblique motion of Arabia with respect to Eurasia is partitioned in this part of Central Iran.

Topographic expression of active faults in the foothills of the Northern Apennines

NASA Astrophysics Data System (ADS)

Picotti, Vincenzo; Ponza, Alessio; Pazzaglia, Frank J.

2009-09-01

Active faults that rupture the earth's surface leave an imprint on the topography that is recognized using a combination of geomorphic and geologic metrics including triangular facets, the shape of mountain fronts, the drainage network, and incised river valleys with inset terraces. We document the presence of a network of active, high-angle extensional faults, collectively embedded in the actively shortening mountain front of the Northern Apennines, that possess unique geomorphic expressions. We measure the strain rate for these structures and find that they have a constant throw-to-length ratio. We demonstrate the necessary and sufficient conditions for triangular facet development in the footwalls of these faults and argue that rock-type exerts the strongest control. The slip rates of these faults range from 0.1 to 0.3 mm/yr, which is similar to the average rate of river incision and mountain front unroofing determined by corollary studies. The faults are a near-surface manifestation of deeper crustal processes that are actively uplifting rocks and growing topography at a rate commensurate with surface processes that are eroding the mountain front to base level.

Reversible Information Flow across the Medial Temporal Lobe: The Hippocampus Links Cortical Modules during Memory Retrieval

PubMed Central

Cooper, Elisa; Henson, Richard N.

2013-01-01

A simple cue can be sufficient to elicit vivid recollection of a past episode. Theoretical models suggest that upon perceiving such a cue, disparate episodic elements held in neocortex are retrieved through hippocampal pattern completion. We tested this fundamental assumption by applying functional magnetic resonance imaging (fMRI) while objects or scenes were used to cue participants' recall of previously paired scenes or objects, respectively. We first demonstrate functional segregation within the medial temporal lobe (MTL), showing domain specificity in perirhinal and parahippocampal cortices (for object-processing vs scene-processing, respectively), but domain generality in the hippocampus (retrieval of both stimulus types). Critically, using fMRI latency analysis and dynamic causal modeling, we go on to demonstrate functional integration between these MTL regions during successful memory retrieval, with reversible signal flow from the cue region to the target region via the hippocampus. This supports the claim that the human hippocampus provides the vital associative link that integrates information held in different parts of cortex. PMID:23986252

MEDIAL TEMPORAL LOBE CONTRIBUTIONS TO FUTURE THINKING: EVIDENCE FROM NEUROIMAGING AND AMNESIA.

PubMed

Verfaellie, Mieke; Race, Elizabeth; Keane, Margaret M

2012-09-01

Following early amnesic case reports, there is now considerable evidence suggesting a link between remembering the past and envisioning the future. This link is evident in the overlap in neural substrates as well as cognitive processes involved in both kinds of tasks. While constructing a future narrative requires multiple processes, neuroimaging and lesion data converge on a critical role for the medial temporal lobes (MTL) in retrieving and recombining details from memory in the service of novel simulations. Deficient detail retrieval and recombination may lead to impairments not only in episodic, but also in semantic prospection. MTL contributions to scene construction and mental time travel may further compound impairments in amnesia on tasks that pose additional demands on these processes, but are unlikely to form the core deficit underlying amnesics' cross-domain future thinking impairment. Future studies exploring the role of episodic memory in other forms of self-projection or future-oriented behaviour may elucidate further the adaptive role of memory.

Fornix and medial temporal lobe lesions lead to comparable deficits in complex visual perception.

PubMed

Lech, Robert K; Koch, Benno; Schwarz, Michael; Suchan, Boris

2016-05-04

Recent research dealing with the structures of the medial temporal lobe (MTL) has shifted away from exclusively investigating memory-related processes and has repeatedly incorporated the investigation of complex visual perception. Several studies have demonstrated that higher level visual tasks can recruit structures like the hippocampus and perirhinal cortex in order to successfully perform complex visual discriminations, leading to a perceptual-mnemonic or representational view of the medial temporal lobe. The current study employed a complex visual discrimination paradigm in two patients suffering from brain lesions with differing locations and origin. Both patients, one with extensive medial temporal lobe lesions (VG) and one with a small lesion of the anterior fornix (HJK), were impaired in complex discriminations while showing otherwise mostly intact cognitive functions. The current data confirmed previous results while also extending the perceptual-mnemonic theory of the MTL to the main output structure of the hippocampus, the fornix. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Risacher, Shannon L.; Kim, Sungeun; Nho, Kwangsik

This study assessed apolipoprotein E (APOE) ε4 carrier status effects on Alzheimer's disease imaging and cerebrospinal fluid (CSF) biomarkers in cognitively normal older adults with significant memory concerns (SMC). Cognitively normal, SMC, and early mild cognitive impairment participants from Alzheimer's Disease Neuroimaging Initiative were divided by APOE ε4 carrier status. Diagnostic and APOE effects were evaluated with emphasis on SMC. Additional analyses in SMC evaluated the effect of the interaction between APOE and [ 18F]Florbetapir amyloid positivity on CSF biomarkers. SMC ε4+ showed greater amyloid deposition than SMC ε4-, but no hypometabolism or medial temporal lobe (MTL) atrophy. SMC ε4+more » showed lower amyloid beta 1-42 and higher tau/p-tau than ε4-, which was most abnormal in APOE ε4+ and cerebral amyloid positive SMC. Lastly, SMC APOE ε4+ show abnormal changes in amyloid and tau biomarkers, but no hypometabolism or MTL neurodegeneration, reflecting the at-risk nature of the SMC group and the importance of APOE in mediating this risk.« less

MEDIAL TEMPORAL LOBE CONTRIBUTIONS TO FUTURE THINKING: EVIDENCE FROM NEUROIMAGING AND AMNESIA

PubMed Central

Verfaellie, Mieke; Race, Elizabeth; Keane, Margaret M.

2013-01-01

Following early amnesic case reports, there is now considerable evidence suggesting a link between remembering the past and envisioning the future. This link is evident in the overlap in neural substrates as well as cognitive processes involved in both kinds of tasks. While constructing a future narrative requires multiple processes, neuroimaging and lesion data converge on a critical role for the medial temporal lobes (MTL) in retrieving and recombining details from memory in the service of novel simulations. Deficient detail retrieval and recombination may lead to impairments not only in episodic, but also in semantic prospection. MTL contributions to scene construction and mental time travel may further compound impairments in amnesia on tasks that pose additional demands on these processes, but are unlikely to form the core deficit underlying amnesics’ cross-domain future thinking impairment. Future studies exploring the role of episodic memory in other forms of self-projection or future-oriented behaviour may elucidate further the adaptive role of memory. PMID:23447709

Right-lateral shear across Iran and kinematic change in the Arabia-Eurasia collision zone

NASA Astrophysics Data System (ADS)

Allen, M. B.; Kheirkhah, M.; Emami, M.

2009-04-01

New offset determinations for right-lateral strike-slip faults in Iran redefine the kinematics of the Arabia-Eurasia collision. A series of right-lateral strike-slip faults is present across Iran between 48° and 57° E. Fault strikes vary between NW-SE and NNW-SSE. Individual faults west of ~53° E were active in the late Tertiary, but have limited evidence of activity. Faults east of ~53° E are seismically active and/or have geomorphic evidence for Holocene slip. None of the faults affects the GPS-derived regional velocity field, indicating active slip rates are ≤2 mm/yr. We estimate overall slip on these faults from offset geological and geomorphic markers, based on observations from satellite imagery, digital topography, geology maps and our own fieldwork observations, and combine these results with published estimates for fault slip in the east of the study area. Total offset of the Takab, Soltanieh, Indes, Bid Hand, Qom, Kashan, Deh Shir, Anar, Daviran, Kuh Banan and Dehu faults is at least 270 km and possibly higher. Other faults (e.g. Rafsanjan) have unknown amounts of right-lateral slip. Collectively, these faults are inferred to have accommodated part of the Arabia-Eurasia convergence by two mechanisms: (1) anti-clockwise, vertical axis rotations; (2) strain partitioning with coeval NE-SW crustal thickening in the Turkish-Iranian plateau to produce ~350 km of north-south plate convergence. The strike-slip faulting across Iran requires along-strike lengthening of the deformation zone. This was possible until the Pliocene, when the Afghan crust collided with the western margin of the Indian plate, thereby sealing off a free face at the eastern side of the Arabia-Eurasia collision zone. Continuing Arabia-Eurasia plate convergence had to be accommodated in new ways and new areas, leading to the present pattern of faulting from eastern Iran to western Turkey.

Combined Application of Shallow Seismic Reflection and High-resolution Refraction Exploration Approach to Active Fault Survey, Central Orogenic Belt, China

NASA Astrophysics Data System (ADS)

Lin, S.; Luo, D.; Yanlin, F.; Li, Y.

2016-12-01

Shallow Seismic Reflection (SSR) is a major geophysical exploration method with its exploration depth range, high-resolution in urban active fault exploration. In this paper, we carried out (SSR) and High-resolution refraction (HRR) test in the Liangyun Basin to explore a buried fault. We used NZ distributed 64 channel seismic instrument, 60HZ high sensitivity detector, Geode multi-channel portable acquisition system and hammer source. We selected single side hammer hit multiple overlay, 48 channels received and 12 times of coverage. As there are some coincidence measuring lines of SSR and HRR, we chose multi chase and encounter observation system. Based on the satellite positioning, we arranged 11 survey lines in our study area with total length for 8132 meters. GEOGIGA seismic reflection data processing software was used to deal with the SSR data. After repeated tests from the aspects of single shot record compilation, interference wave pressing, static correction, velocity parameter extraction, dynamic correction, eventually got the shallow seismic reflection profile images. Meanwhile, we used Canadian technology company good refraction and tomographic imaging software to deal with HRR seismic data, which is based on nonlinear first arrival wave travel time tomography. Combined with drilling geological profiles, we explained 11 measured seismic profiles. Results show 18 obvious fault feature breakpoints, including 4 normal faults of south-west, 7 reverse faults of south-west, one normal fault of north-east and 6 reverse faults of north-east. Breakpoints buried depth is 15-18 meters, and the inferred fault distance is 3-12 meters. Comprehensive analysis shows that the fault property is reverse fault with northeast incline section, and fewer branch normal faults presenting southwest incline section. Since good corresponding relationship between the seismic interpretation results, drilling data and SEM results on the property, occurrence, broken length of the fault, we considered the Liangyun fault to be an active fault which has strong activity during the Neogene Pliocene and early Pleistocene, Middle Pleistocene period. The combined application of SSR and HRR can provide more parameters to explain the seismic results, and improve the accuracy of the interpretation.

Characterizing the structural maturity of fault zones using high-resolution earthquake locations.

NASA Astrophysics Data System (ADS)

Perrin, C.; Waldhauser, F.; Scholz, C. H.

2017-12-01

We use high-resolution earthquake locations to characterize the three-dimensional structure of active faults in California and how it evolves with fault structural maturity. We investigate the distribution of aftershocks of several recent large earthquakes that occurred on immature faults (i.e., slow moving and small cumulative displacement), such as the 1992 (Mw7.3) Landers and 1999 (Mw7.1) Hector Mine events, and earthquakes that occurred on mature faults, such as the 1984 (Mw6.2) Morgan Hill and 2004 (Mw6.0) Parkfield events. Unlike previous studies which typically estimated the width of fault zones from the distribution of earthquakes perpendicular to the surface fault trace, we resolve fault zone widths with respect to the 3D fault surface estimated from principal component analysis of local seismicity. We find that the zone of brittle deformation around the fault core is narrower along mature faults compared to immature faults. We observe a rapid fall off of the number of events at a distance range of 70 - 100 m from the main fault surface of mature faults (140-200 m fault zone width), and 200-300 m from the fault surface of immature faults (400-600 m fault zone width). These observations are in good agreement with fault zone widths estimated from guided waves trapped in low velocity damage zones. The total width of the active zone of deformation surrounding the main fault plane reach 1.2 km and 2-4 km for mature and immature faults, respectively. The wider zone of deformation presumably reflects the increased heterogeneity in the stress field along complex and discontinuous faults strands that make up immature faults. In contrast, narrower deformation zones tend to align with well-defined fault planes of mature faults where most of the deformation is concentrated. Our results are in line with previous studies suggesting that surface fault traces become smoother, and thus fault zones simpler, as cumulative fault slip increases.

Investigation of late Pleistocene and Holocene activity in the San Gregorio fault zone on the continental slope north of Monterey Canyon, offshore central California

USGS Publications Warehouse

Maier, Katherine L.; Paull, Charles K.; Brothers, Daniel; Caress, David W.; McGann, Mary; Lundsten, Eve M.; Anderson, Krystle; Gwiazda, Roberto

2017-01-01

We provide an extensive high‐resolution geophysical, sediment core, and radiocarbon dataset to address late Pleistocene and Holocene fault activity of the San Gregorio fault zone (SGFZ), offshore central California. The SGFZ occurs primarily offshore in the San Andreas fault system and has been accommodating dextral strike‐slip motion between the Pacific and North American plates since the mid‐Miocene. Our study focuses on the SGFZ where it has been mapped through the continental slope north of Monterey Canyon. From 2009 to 2015, the Monterey Bay Aquarium Research Institute collected high‐resolution multibeam bathymetry and chirp sub‐bottom profiles using an autonomous underwater vehicle (AUV). Targeted samples were collected using a remotely operated vehicle (ROV) to provide radiocarbon age constraints. We integrate the high‐resolution geophysical data with radiocarbon dates to reveal Pleistocene seismic horizons vertically offset less than 5 m on nearly vertical faults. These faults are buried by continuous reflections deposited after ∼17.5  ka and likely following erosion during the last sea‐level lowstand ∼21  ka, bracketing the age of faulting to ∼32–21  ka. Clearly faulted horizons are only detected in a small area where mass wasting exhumed older strata to within ∼25  m of the seafloor. The lack of clearly faulted Holocene deposits and possible highly distributed faulting in the study area are consistent with previous interpretations that late Pleistocene and Holocene activity along the SGFZ may decrease to the south. This study illustrates the complexity of the SGFZ, offshore central California, and demonstrates the utility of very high‐resolution data from combined AUV (geophysical)–ROV (seabed sampling) surveys in offshore studies of fault activity.

Petrophysical, Geochemical, and Hydrological Evidence for Extensive Fracture-Mediated Fluid and Heat Transport in the Alpine Fault's Hanging-Wall Damage Zone

NASA Astrophysics Data System (ADS)

Townend, John; Sutherland, Rupert; Toy, Virginia G.; Doan, Mai-Linh; Célérier, Bernard; Massiot, Cécile; Coussens, Jamie; Jeppson, Tamara; Janku-Capova, Lucie; Remaud, Léa.; Upton, Phaedra; Schmitt, Douglas R.; Pezard, Philippe; Williams, Jack; Allen, Michael John; Baratin, Laura-May; Barth, Nicolas; Becroft, Leeza; Boese, Carolin M.; Boulton, Carolyn; Broderick, Neil; Carpenter, Brett; Chamberlain, Calum J.; Cooper, Alan; Coutts, Ashley; Cox, Simon C.; Craw, Lisa; Eccles, Jennifer D.; Faulkner, Dan; Grieve, Jason; Grochowski, Julia; Gulley, Anton; Hartog, Arthur; Henry, Gilles; Howarth, Jamie; Jacobs, Katrina; Kato, Naoki; Keys, Steven; Kirilova, Martina; Kometani, Yusuke; Langridge, Rob; Lin, Weiren; Little, Tim; Lukacs, Adrienn; Mallyon, Deirdre; Mariani, Elisabetta; Mathewson, Loren; Melosh, Ben; Menzies, Catriona; Moore, Jo; Morales, Luis; Mori, Hiroshi; Niemeijer, André; Nishikawa, Osamu; Nitsch, Olivier; Paris, Jehanne; Prior, David J.; Sauer, Katrina; Savage, Martha K.; Schleicher, Anja; Shigematsu, Norio; Taylor-Offord, Sam; Teagle, Damon; Tobin, Harold; Valdez, Robert; Weaver, Konrad; Wiersberg, Thomas; Zimmer, Martin

2017-12-01

Fault rock assemblages reflect interaction between deformation, stress, temperature, fluid, and chemical regimes on distinct spatial and temporal scales at various positions in the crust. Here we interpret measurements made in the hanging-wall of the Alpine Fault during the second stage of the Deep Fault Drilling Project (DFDP-2). We present observational evidence for extensive fracturing and high hanging-wall hydraulic conductivity (˜10-9 to 10-7 m/s, corresponding to permeability of ˜10-16 to 10-14 m2) extending several hundred meters from the fault's principal slip zone. Mud losses, gas chemistry anomalies, and petrophysical data indicate that a subset of fractures intersected by the borehole are capable of transmitting fluid volumes of several cubic meters on time scales of hours. DFDP-2 observations and other data suggest that this hydrogeologically active portion of the fault zone in the hanging-wall is several kilometers wide in the uppermost crust. This finding is consistent with numerical models of earthquake rupture and off-fault damage. We conclude that the mechanically and hydrogeologically active part of the Alpine Fault is a more dynamic and extensive feature than commonly described in models based on exhumed faults. We propose that the hydrogeologically active damage zone of the Alpine Fault and other large active faults in areas of high topographic relief can be subdivided into an inner zone in which damage is controlled principally by earthquake rupture processes and an outer zone in which damage reflects coseismic shaking, strain accumulation and release on interseismic timescales, and inherited fracturing related to exhumation.

Kinematic Evolution of the North-Tehran Fault (NTF), Alborz Mountains, Iran

NASA Astrophysics Data System (ADS)

Landgraf, A.; Ballato, P.; Strecker, M. R.; Shahpasandzadeh, M.; Friedrich, A.; Tabatabaei, S. H.

2007-12-01

The ENE-to NW-striking NTF is an active frontal thrust that delimits the Alborz Mountain range to the south with an up to 2000 m topographic break with respect to the adjacent Tehran plain. Eocene rocks of the Alborz range are thrusted over Neogene and Quaternary sediments of the alluvial Tehran embayment. The fault consists of right- stepping segments and merges to the east with the active Mosha-Fasham strike-slip fault (MFF). The complex tectonic history, involving changes in the direction of SHmax, has resulted in a composite tectonic landscape with inherited topographic and fault-kinematic fingerprints along the NTF. We therefore used a combination of fault-kinematic measurements and geomorphic observations to unravel the temporal tectonic evolution of this fault. Presently, the NTF is virtually inactive, although the tectonically overprinted landforms reflect tectonic activity on longer time scales during the Quaternary. Being located adjacent north of the Tehran megacity, there is thus considerable interest to decipher its youngest tectonic evolution and to better understand the relation with other fault systems. Our fault kinematic study has revealed an early dextral kinematic history for the NTF. Dextral strike-slip and oblique reverse faulting took place during NW-oriented shortening. The overall fault-geometry of the NTF suggests that it has evolved in relation to dextral transpression along the MFF. This early kinematic regime was superseded by NE-oriented shortening, associated with sinistral-oblique thrusting along the fault segments. Fault linkage between the semi-independent ENE-striking NTF-segments and NW-striking thrusts (Emamzadeh Davud Fault [EDF], Purkan Vardij Thrust [PVT], NTF-prolongation) point towards an evolution into a nascent transpressional duplex. In this scenario the NTF segments constitute lateral ramps and the NW-striking faults act as frontal ramps. Topographic residuals, as an expression of high-uplift zones, indicate that the central segment of the NTF, incorporating the EDF was most effective in accommodating oblique convergence during this time. However, subtle knickpoints in the longitudinal river profiles crossing the PVT may indicate a relatively recent transfer of deformation onto this block. The youngest manifestations of deformation along the NTF, however, are left-lateral and normal faulting. This youngest phase of activity is documented by numerous striated and rotated conglomeratic clasts, meter-scale fault gouge zones with shear-sense indicators of oblique normal faulting, and multiple colluvial wedges with drag phenomena. Rupture traces and filled extensional cracks reaching the surface also document the seismogenic nature of these features. Since recent left-lateral transtension is also known from neighboring faults, e.g., the eastern MFF, our observations suggest that this youngest phase of tectonic activity of the NTF is a regional phenomenon, rather than the result of locally-determined geometries.

The Gabbs Valley, Nevada, geothermal prospect: Exploring for a potential blind geothermal resource

NASA Astrophysics Data System (ADS)

Payne, J.; Bell, J. W.; Calvin, W. M.

2012-12-01

The Gabbs Valley prospect in west-central Nevada is a potential blind geothermal resource system. Possible structural controls on this system were investigated using high-resolution LiDAR, low sun-angle aerial (LSA) photography, exploratory fault trenching and a shallow temperature survey. Active Holocene faults have previously been identified at 37 geothermal systems with indication of temperatures greater than 100° C in the western Nevada region. Active fault controls in Gabbs Valley include both Holocene and historical structures. Two historical earthquakes occurring in 1932 and 1954 have overlapping surface rupture patterns in Gabbs Valley. Three active fault systems identified through LSA and LiDAR mapping have characteristics of Basin and Range normal faulting and Walker Lane oblique dextral faulting. The East Monte Cristo Mountains fault zone is an 8.5 km long continuous NNE striking, discrete fault with roughly 0.5 m right-normal historic motion and 3 m vertical Quaternary separation. The Phillips Wash fault zone is an 8.2 km long distributed fault system striking NE to N, with Quaternary fault scarps of 1-3 m vertical separation and a 500 m wide graben adjacent to the Cobble Cuesta anticline. This fault displays ponded drainages, an offset terrace riser and right stepping en echelon fault patterns suggestive of left lateral offset, and fault trenching exposed non-matching stratigraphy typical of a significant component of lateral offset. The unnamed faults of Gabbs Valley are a 10.6 km long system of normal faults striking NNE and Quaternary scarps are up to 4 m high. These normal faults largely do not have historic surface rupture, but a small segment of 1932 rupture has been identified. A shallow (2 m deep) temperature survey of 80 points covering roughly 65 square kilometers was completed. Data were collected over approximately 2 months, and continual base station temperature measurements were used to seasonally correct temperature measurements. A 2.5 km long temperature anomaly greater than 3° C above background temperatures forms west-northwest trending zone between terminations of the Phillips Wash fault zone and unnamed faults of Gabbs Valley to the south. Rupture segments of two young active faults bracket the temperature anomaly. The temperature anomaly may be due to several possible causes. 1. Increases in stress near the rupture segments or tip-lines of these faults, or where multiple fault splays exist, can increase fault permeability. The un-ruptured segments of these faults may be controlling the location of the Gabbs Valley thermal anomaly between ruptured segments of the 1932 Cedar Mountain and 1954 Fairview Peak earthquakes. 2. Numerous unnamed normal faults may interact and the hanging wall of these faults is hosting the thermal anomaly. The size and extent of the anomaly may be due to its proximity to a flat playa and not the direct location of the shallow heat anomaly. 3. The linear northwest nature of the thermal anomaly may reflect a hydrologic barrier in the subsurface controlling where heated fluids rise. A concealed NW- striking fault is possible, but has not been identified in previous studies or in the LiDAR or LSA fault mapping.

The West Beverly Hills Lineament and Beverly Hills High School: Ethical Issues in Geo-Hazard Communication

NASA Astrophysics Data System (ADS)

Gath, Eldon; Gonzalez, Tania; Roe, Joe; Buchiarelli, Philip; Kenny, Miles

2014-05-01

Results of geotechnical studies for the Westside Subway were disclosed in a public hearing on Oct. 19, 2011, showing new "active faults" of the Santa Monica fault and the West Beverly Hills Lineament (WBHL), identified as a northern extension of the Newport-Inglewood fault. Presentations made spoke of the danger posed by these faults, the possibility of killing people, and how it was good news that these faults had been discovered now instead of later. The presentations were live and are now memorialized as YouTube videos, (http://www.youtube.com/watch?v=Omx2BTIpzAk and others). No faults had been physically exposed or observed by the study; the faults were all interpreted from cone penetrometer probes, supplemented by core borings and geophysical transects. Several of the WBHL faults traversed buildings of the Beverly Hills High School (BHHS), triggering the school district to geologically map and characterize these faults for future planning efforts, and to quantify risk to the students in the 1920's high school building. 5 exploratory trenches were excavated within the high school property, 12 cone penetrometers were pushed, and 26-cored borings were drilled. Geologic logging of the trenches and borings and interpretation of the CPT data failed to confirm the presence of the mapped WBHL faults, instead showing an unfaulted, 3° NE dipping sequence of mid-Pleistocene alluvial fan deposits conformably overlying an ~1 Ma marine sand. Using 14C, OSL, and soil pedology for stratigraphic dating, the BHHS site was cleared from fault rupture hazards and the WBHL was shown to be an erosional margin of Benedict Canyon, partially buttressed by 40-200 ka alluvial deposits from Benedict Wash. The consequence of the Westside Subway's active fault maps has been the unexpected expenditure of millions of dollars for emergency fault investigations at BHHS and several other private properties within a densely developed urban highrise environment. None of these studies have found any active faults where they had been interpreted, mapped, and published by the subway's consultants. Litigation is underway by the affected parties to recoup their geological expenditures and recover costs for lost business revenues. Even had the active fault map been correct, its public release was poorly managed. That the released active fault map has now been found to be badly in error poses more significant ethical issues about hazard communication and likely legal consequences.

Shallow subsurface imaging of the Piano di Pezza active normal fault (central Italy) by high-resolution refraction and electrical resistivity tomography coupled with time-domain electromagnetic data

NASA Astrophysics Data System (ADS)

Villani, Fabio; Tulliani, Valerio; Sapia, Vincenzo; Fierro, Elisa; Civico, Riccardo; Pantosti, Daniela

2015-12-01

The Piano di Pezza fault is the central section of the 35 km long L'Aquila-Celano active normal fault-system in the central Apennines of Italy. Although palaeoseismic data document high Holocene vertical slip rates (˜1 mm yr-1) and a remarkable seismogenic potential of this fault, its subsurface setting and Pleistocene cumulative displacement are still poorly known. We investigated for the first time the shallow subsurface of a key section of the main Piano di Pezza fault splay by means of high-resolution seismic and electrical resistivity tomography coupled with time-domain electromagnetic soundings (TDEM). Our surveys cross a ˜5-m-high fault scarp that was generated by repeated surface-rupturing earthquakes displacing Holocene alluvial fans. We provide 2-D Vp and resistivity images, which show significant details of the fault structure and the geometry of the shallow basin infill material down to 50 m depth. Our data indicate that the upper fault termination has a sub-vertical attitude, in agreement with palaeoseismological trench evidence, whereas it dips ˜50° to the southwest in the deeper part. We recognize some low-velocity/low-resistivity regions in the fault hangingwall that we relate to packages of colluvial wedges derived from scarp degradation, which may represent the record of some Holocene palaeo-earthquakes. We estimate a ˜13-15 m throw of this fault splay since the end of the Last Glacial Maximum (˜18 ka), leading to a 0.7-0.8 mm yr-1 throw rate that is quite in accordance with previous palaeoseismic estimation of Holocene vertical slip rates. The 1-D resistivity models from TDEM soundings collected along the trace of the electrical profile significantly match with 2-D resistivity images. Moreover, they indicate that in the fault hangingwall, ˜200 m away from the surface fault trace, the pre-Quaternary carbonate basement is at ˜90-100 m depth. We therefore provide a minimal ˜150-160 m estimate of the cumulative throw of the Piano di Pezza fault system in the investigated section. We further hypothesize that the onset of the Piano di Pezza fault activity may date back to the Middle Pleistocene (˜0.5 Ma), so this is a quite young active normal fault if compared to other mature normal fault systems active since 2-3 Ma in this portion of the central Apennines.

Insurance Applications of Active Fault Maps Showing Epistemic Uncertainty

NASA Astrophysics Data System (ADS)

Woo, G.

2005-12-01

Insurance loss modeling for earthquakes utilizes available maps of active faulting produced by geoscientists. All such maps are subject to uncertainty, arising from lack of knowledge of fault geometry and rupture history. Field work to undertake geological fault investigations drains human and monetary resources, and this inevitably limits the resolution of fault parameters. Some areas are more accessible than others; some may be of greater social or economic importance than others; some areas may be investigated more rapidly or diligently than others; or funding restrictions may have curtailed the extent of the fault mapping program. In contrast with the aleatory uncertainty associated with the inherent variability in the dynamics of earthquake fault rupture, uncertainty associated with lack of knowledge of fault geometry and rupture history is epistemic. The extent of this epistemic uncertainty may vary substantially from one regional or national fault map to another. However aware the local cartographer may be, this uncertainty is generally not conveyed in detail to the international map user. For example, an area may be left blank for a variety of reasons, ranging from lack of sufficient investigation of a fault to lack of convincing evidence of activity. Epistemic uncertainty in fault parameters is of concern in any probabilistic assessment of seismic hazard, not least in insurance earthquake risk applications. A logic-tree framework is appropriate for incorporating epistemic uncertainty. Some insurance contracts cover specific high-value properties or transport infrastructure, and therefore are extremely sensitive to the geometry of active faulting. Alternative Risk Transfer (ART) to the capital markets may also be considered. In order for such insurance or ART contracts to be properly priced, uncertainty should be taken into account. Accordingly, an estimate is needed for the likelihood of surface rupture capable of causing severe damage. Especially where a high deductible is in force, this requires estimation of the epistemic uncertainty on fault geometry and activity. Transport infrastructure insurance is of practical interest in seismic countries. On the North Anatolian Fault in Turkey, there is uncertainty over an unbroken segment between the eastern end of the Dazce Fault and Bolu. This may have ruptured during the 1944 earthquake. Existing hazard maps may simply use a question mark to flag uncertainty. However, a far more informative type of hazard map might express spatial variations in the confidence level associated with a fault map. Through such visual guidance, an insurance risk analyst would be better placed to price earthquake cover, allowing for epistemic uncertainty.

Transfer fault earthquake in compressionally reactivated back-arc failed rift: 1948 Fukui earthquake (M7.1), Japan

NASA Astrophysics Data System (ADS)

Ishiyama, Tatsuya; Kato, Naoko; Sato, Hiroshi; Koshiya, Shin

2017-04-01

Back-arc rift structures in many subduction zones are recognized as mechanically and thermally weak zones that possibly play important roles in strain accommodation at later post-rift stages within the overriding plates. In case of Miocene back-arc failed rift structures in the Sea of Japan in the Eurasian-Pacific subduction system, the mechanical contrasts between the crustal thrust wedges of the pre-rift continental crust and high velocity lower crust have fundamentally controlled the styles of post-rift, Quaternary active deformation (Ishiyama et al. 2016). In this study, we show a possibility that strike-slip M>7 devastating earthquakes in this region have been gregion enerated by reactivation of transfer faults highly oblique to the rift axes. The 1948 Fukui earthquake (M7.1), onshore shallow seismic event with a strike-slip faulting mechanism (Kanamori, 1973), resulted in more than 3,500 causalities and destructive damages on the infrastructures. While geophysical analyses on geodetic measurements based on leveling and triangulation networks clearly show coseismic left-lateral fault slip on a NNW striking vertical fault plane beneath the Fukui plain (Sagiya, 1999), no evidence for coseismic surface rupture has been identified based on both post-earthquake intensive fieldwork and recent reexamination of stereopair interpretations using 1/3,000 aerial photographs taken in 1948 (Togo et al., 2000). To find recognizable fault-related structures that deform Neogene basin fill sediments, we collected new 9.6-km-long high-resolution seismic reflection data across the geodetically estimated fault plane and adjacent subparallel active strike slip faults, using 925 offline recorders and Envirovib truck as a seismic source. A depth-converted section to 1.5 km depth contains discontinuous seismic reflectors correlated to Miocene volcaniclastic deposits and depression of the overlying Plio-Pleistocene sediments above the geodetically determined fault plane. We interpreted these structural features as negative flower structures related to the strike-slip fault activated during the 1948 seismic event. Locations of these strike-slip faults are consistent with Miocene transfer faults that offset syn- and post-rift sediments and underlying crustal wedges, suggesting that reactivation of transfer faults resulted in active strike-slip faulting including the 1948 seismic event. These findings demonstrate that not only rift-related normal faults but also transfer faults have strong structural inheritances and played essential roles on their active reactivation and seismicity during the post-rift stress regime.

Strike-slip faulting in the Inner California Borderlands, offshore Southern California.

NASA Astrophysics Data System (ADS)

Bormann, J. M.; Kent, G. M.; Driscoll, N. W.; Harding, A. J.; Sahakian, V. J.; Holmes, J. J.; Klotsko, S.; Kell, A. M.; Wesnousky, S. G.

2015-12-01

In the Inner California Borderlands (ICB), offshore of Southern California, modern dextral strike-slip faulting overprints a prominent system of basins and ridges formed during plate boundary reorganization 30-15 Ma. Geodetic data indicate faults in the ICB accommodate 6-8 mm/yr of Pacific-North American plate boundary deformation; however, the hazard posed by the ICB faults is poorly understood due to unknown fault geometry and loosely constrained slip rates. We present observations from high-resolution and reprocessed legacy 2D multichannel seismic (MCS) reflection datasets and multibeam bathymetry to constrain the modern fault architecture and tectonic evolution of the ICB. We use a sequence stratigraphy approach to identify discrete episodes of deformation in the MCS data and present the results of our mapping in a regional fault model that distinguishes active faults from relict structures. Significant differences exist between our model of modern ICB deformation and existing models. From east to west, the major active faults are the Newport-Inglewood/Rose Canyon, Palos Verdes, San Diego Trough, and San Clemente fault zones. Localized deformation on the continental slope along the San Mateo, San Onofre, and Carlsbad trends results from geometrical complexities in the dextral fault system. Undeformed early to mid-Pleistocene age sediments onlap and overlie deformation associated with the northern Coronado Bank fault (CBF) and the breakaway zone of the purported Oceanside Blind Thrust. Therefore, we interpret the northern CBF to be inactive, and slip rate estimates based on linkage with the Holocene active Palos Verdes fault are unwarranted. In the western ICB, the San Diego Trough fault (SDTF) and San Clemente fault have robust linear geomorphic expression, which suggests that these faults may accommodate a significant portion of modern ICB slip in a westward temporal migration of slip. The SDTF offsets young sediments between the US/Mexico border and the eastern margin of Avalon Knoll, where the fault is spatially coincident and potentially linked with the San Pedro Basin fault (SPBF). Kinematic linkage between the SDTF and the SPBF increases the potential rupture length for earthquakes on either fault and may allow events nucleating on the SDTF to propagate much closer to the LA Basin.

Influence of the Saros Fault on the Periodicity of Earthquake Activity (Gelibolu Peninsula, NW Turkey)

NASA Astrophysics Data System (ADS)

İpek Gültekin, Derya; Karakoç, Okan; Şahin, Murat; Elitez, İrem; Yaltırak, Cenk

2017-04-01

Active faults are vital in terms of settlement and socio-economic aspects of a region. For this reason, it is important to determine the characteristics and impact areas of active faults correctly. The Marmara region is a tectonically active region located in the northwestern Anatolia. The northern part of the North Anatolian Fault, which was named the Saros Fault, passes through the westernmost part of this region. The Saros Fault is a 52 km-long and NE-SW-trending right-lateral strike-slip fault. In this study, the seismicity of the Gelibolu Peninsula has been examined in the light of historical records. When considering the historical records, 545, 986, 1354 and 1756 earthquakes led to damage on the settlements close to the Saros Fault. The dates of historical earthquakes were calculated by integration of previously published empirical formulas, year difference between events and velocity of GPS vectors. The acceleration map (PGA MAPS) of the region has been produced by taking into account these earthquake magnitudes, fault geometry and geology of the region, and consequently, it was seen that these maps overlap quite well with the damage records of historical earthquakes. Considering the periodicity of the Saros Fault, which majorly controls the seismicity in the region, it is aimed to find an answer to the question "how does a recent earthquake affect the region?" by the help of historical earthquake records and PGA modelling. In conclusion, our data showed that PGA values are dominant in the northern side of the Gelibolu Peninsula and this region may be affected by a magnitude 7.3 earthquake.

Active tectonics of the Seattle fault and central Puget sound, Washington - Implications for earthquake hazards

USGS Publications Warehouse

Johnson, S.Y.; Dadisman, S.V.; Childs, J. R.; Stanley, W.D.

1999-01-01

We use an extensive network of marine high-resolution and conventional industry seismic-reflection data to constrain the location, shallow structure, and displacement rates of the Seattle fault zone and crosscutting high-angle faults in the Puget Lowland of western Washington. Analysis of seismic profiles extending 50 km across the Puget Lowland from Lake Washington to Hood Canal indicates that the west-trending Seattle fault comprises a broad (4-6 km) zone of three or more south-dipping reverse faults. Quaternary sediment has been folded and faulted along all faults in the zone but is clearly most pronounced along fault A, the northernmost fault, which forms the boundary between the Seattle uplift and Seattle basin. Analysis of growth strata deposited across fault A indicate minimum Quaternary slip rates of about 0.6 mm/yr. Slip rates across the entire zone are estimated to be 0.7-1.1 mm/yr. The Seattle fault is cut into two main segments by an active, north-trending, high-angle, strike-slip fault zone with cumulative dextral displacement of about 2.4 km. Faults in this zone truncate and warp reflections in Tertiary and Quaternary strata and locally coincide with bathymetric lineaments. Cumulative slip rates on these faults may exceed 0.2 mm/yr. Assuming no other crosscutting faults, this north-trending fault zone divides the Seattle fault into 30-40-km-long western and eastern segments. Although this geometry could limit the area ruptured in some Seattle fault earthquakes, a large event ca. A.D. 900 appears to have involved both segments. Regional seismic-hazard assessments must (1) incorporate new information on fault length, geometry, and displacement rates on the Seattle fault, and (2) consider the hazard presented by the previously unrecognized, north-trending fault zone.

Steep-dip seismic imaging of the shallow San Andreas Fault near Parkfield

USGS Publications Warehouse

Hole, J.A.; Catchings, R.D.; St. Clair, K.C.; Rymer, M.J.; Okaya, D.A.; Carney, B.J.

2001-01-01

Seismic reflection and refraction images illuminate the San Andreas Fault to a depth of 1 kilometer. The prestack depth-migrated reflection image contains near-vertical reflections aligned with the active fault trace. The fault is vertical in the upper 0.5 kilometer, then dips about 70° to the southwest to at least 1 kilometer subsurface. This dip reconciles the difference between the computed locations of earthquakes and the surface fault trace. The seismic velocity cross section shows strong lateral variations. Relatively low velocity (10 to 30%), high electrical conductivity, and low density indicate a 1-kilometer-wide vertical wedge of porous sediment or fractured rock immediately southwest of the active fault trace.

Map and database of Quaternary faults and folds in Colombia and its offshore regions

USGS Publications Warehouse

Paris, Gabriel; Machette, Michael N.; Dart, Richard L.; Haller, Kathleen M.

2000-01-01

As part of the International Lithosphere Program’s “World Map of Major Active Faults,” the U.S. Geological Survey (USGS) is assisting in the compilation of a series of digital maps of Quaternary faults and folds in Western Hemisphere countries. The maps show the locations, ages, and activity rates of major earthquake-related features such as faults and fault-related folds. They are accompanied by databases that describe these features and document current information on their activity in the Quaternary. Top date, the project has published fault and fold maps for Costa Rica (Montero and others, 1998), Panama (Cowan and others, 1998), Venezuela (Audemard and others, 2000), Bolovia/Chile (Lavenu, and others, 2000), and Argentina (Costa and others, 2000). The project is a key part of the Global Seismic Hazards Assessment Program (ILP Project II-0) for the International Decade for Natural Hazard Disaster Reduction.

Coulomb stress analysis of the 21 February 2008 Mw= 6.0 Wells, Nevada, earthquake

USGS Publications Warehouse

Sevilgen, Volkan

2011-01-01

Static Coulomb stress changes imparted by the February 21, 2008 Wells, Nevada earthquake are calculated, using an 8 x 6 km rectangular patch with a uniform slip as a source fault. Stress changes are resolved on nearby active faults using their rake, dip, and strike direction, assuming a fault friction of 0.4. The largest Coulomb stress increase (0.2 bars) imparted to surrounding major active faults from the Wells earthquake occurs on the Clover Hill fault, which may be the southern continuation of the ruptured fault. A 0.1 bar Coulomb stress increase is calculated on the western Snake Mountains fault. Coulomb stress decreases of 0.5 bars are calculated for the northern parts of the Independence and Ruby Mountains faults. The Coulomb stress change is calculated on relocated aftershocks assuming that they have the same strike, dip, and rake, as the source fault. Under this assumption, 75% of the aftershocks received a Coulomb stress increase.

Evolved α-factor prepro-leaders for directed laccase evolution in Saccharomyces cerevisiae.

PubMed

Mateljak, Ivan; Tron, Thierry; Alcalde, Miguel

2017-11-01

Although the functional expression of fungal laccases in Saccharomyces cerevisiae has proven to be complicated, the replacement of signal peptides appears to be a suitable approach to enhance secretion in directed evolution experiments. In this study, twelve constructs were prepared by fusing native and evolved α-factor prepro-leaders from S. cerevisiae to four different laccases with low-, medium- and high-redox potential (PM1L from basidiomycete PM1; PcL from Pycnoporus cinnabarinus; TspC30L from Trametes sp. strain C30; and MtL from Myceliophthora thermophila). Microcultures of the prepro-leader:laccase fusions were grown in selective expression medium that used galactose as both the sole carbon source and as the inducer of expression so that the secretion and activity were assessed with low- and high-redox potential mediators in a high-throughput screening context. With total activity improvements as high as sevenfold over those obtained with the native α-factor prepro-leader, the evolved prepro-leader from PcL (α PcL ) most strongly enhanced secretion of the high- and medium-redox potential laccases PcL, PM1L and TspC30L in the microtiter format with an expression pattern driven by prepro-leaders in the order α PcL  > α PM 1L  ~ α native . By contrast, the pattern of the low-redox potential MtL was α native  > α PcL  > α PM 1L . When produced in flask with rich medium, the evolved prepro-leaders outperformed the α native signal peptide irrespective of the laccase attached, enhancing secretion over 50-fold. Together, these results highlight the importance of using evolved α-factor prepro-leaders for functional expression of fungal laccases in directed evolution campaigns. © 2017 The Authors. Microbial Biotechnology published by John Wiley & Sons Ltd and Society for Applied Microbiology.

Kinematic vicissitudes and the spatial distribution of the alteration zone related to the Byobuyama fault, central Japan. (Implication; Influence of another faults.)

NASA Astrophysics Data System (ADS)

Katori, T.; Kobayashi, K.

2015-12-01

The central Japan is one of the most concentrated area of active faults (Quaternary fault). These are roughly classified into two orthogonally-oriented fault sets of NE-SW and NW-SE strikes. The study area is located in Gifu prefecture, central Japan. In there, the basement rocks are composed mainly of Triassic-Jurassic accretionary prism (Mino belt), Cretaceous Nohi Rhyolite and Cretaceous granitic rocks. Miocene Mizunami G. and Pliocene-Pleistocene Toki Sand and Gravel F. unconformably cover the basement rocks. The Byobuyama fault, 32 km in length, is NE-SW strike and displaces perpendicularly the Toki Sand and Gravel F. by 500 m. The northeastern terminal of the fault has contact with the southern terminal of the Atera fault of NW-SE strike and offset their displacements each other. It is clear that the activity of the Byobuyama fault plays a role of the development of the complicated fault geometry system in the central Japan. In this study, we performed a broad-based investigation along the Byobuyama fault and collected samples. Actually, we observed 400 faults and analyzed 200 fault rocks. Based on these results, we obtained the following new opinion. 1. The Byobuyama fault has experienced following activities that can be divided to 3 stages at least under different stress field. 1) Movement with the sinisterly sense (preserved in cataclasite zone). 2) Dextral movement (preserved in fault gouge zone). 3) Reverse fault movement (due to the aggressive rise of mountains). In addition, the change from Stage 2 to Stage 3 is a continuous. 2. There is a relationship between the distance from the trace of the Byobuyama fault and the combination of alteration minerals included in the fault rocks. 3. In the central part of the Byobuyama fault (CPBF), fault plane trend and combination of alteration minerals shows specific features. The continuous change is considered to mean the presence of factors that interfere with the dextral movement of the Byobuyama fault. What is considered as one of the factors is the effect of the fault zone adjacent, especially the Atera fault. CPBF is located just southeast extension of the Akou fault, NW-SE strike. We think that this extension reaches up to CPBF. Based on the above, we make a presentation about interaction of two faults from the point of view of kinematic vicissitudes and alteration process.

Detecting Taiwan's Shanchiao Active Fault Using AMT and Gravity Methods

NASA Astrophysics Data System (ADS)

Liu, H.-C.; Yang, C.-H.

2009-04-01

Taiwan's Shanchiao normal fault runs in a northeast-southwest direction and is located on the western edge of the Taipei Basin in northern Taiwan. The overburden of the fault is late Quaternary sediment with a thickness of approximately a few tenth of a meter to several hundred meters. No detailed studies of the western side of the Shanchiao fault are available. As Taiwan is located on the Neotectonic Belt in the western Pacific, detecting active faults near the Taipei metropolitan area will provide necessary information for further disaster prevention. It is the responsibility of geologists and geophysicists in Taiwan to perform this task. Examination of the resistivity and density contrasts of subsurface layers permits a mapping of the Shanchiao fault and the deformed Tertiary strata of the Taipei Basin. The audio-frequency magnetotelluric (AMT) method and gravity method were chosen for this study. Significant resistivity and gravity anomalies were observed in the suspected fault zone. The interpretation reveals a good correlation between the features of the Shanchiao fault and resistivity and density distribution at depth. In this observation, AMT and gravity methods provides a viable means for mapping the Shanchiao fault position and studying its features associated with the subsidence of the western side of the Taipei Basin. This study indicates the AMT and gravity methods' considerable potential for accurately mapping an active fault.

Active tectonics of the onshore Hengchun Fault using UAS DSM combined with ALOS PS-InSAR time series (Southern Taiwan)

NASA Astrophysics Data System (ADS)

Deffontaines, Benoit; Chang, Kuo-Jen; Champenois, Johann; Lin, Kuan-Chuan; Lee, Chyi-Tyi; Chen, Rou-Fei; Hu, Jyr-Ching; Magalhaes, Samuel

2018-03-01

Characterizing active faults and quantifying their activity are major concerns in Taiwan, especially following the major Chichi earthquake on 21 September 1999. Among the targets that still remain poorly understood in terms of active tectonics are the Hengchun and Kenting faults (Southern Taiwan). From a geodynamic point of view, the faults affect the outcropping top of the Manila accretionary prism of the Manila subduction zone that runs from Luzon (northern Philippines) to Taiwan. In order to better locate and quantify the location and quantify the activity of the Hengchun Fault, we start from existing geological maps, which we update thanks to the use of two products derived from unmanned aircraft system acquisitions: (1) a very high precision (< 50 cm) and resolution (< 10 cm) digital surface model (DSM) and (2) a georeferenced aerial photograph mosaic of the studied area. Moreover, the superimposition of the resulting structural sketch map with new Persistent Scatterer Interferometric Synthetic Aperture Radar (PS-InSAR) results obtained from PALSAR ALOS images, validated by Global Positioning System (GPS) and leveling data, allows the characterization and quantification of the surface displacements during the monitoring period (2007-2011). We confirm herein the geometry, characterization and quantification of the active Hengchun Fault deformation, which acts as an active left-lateral transpressive fault. As the Hengchun ridge was the location of one of the last major earthquakes in Taiwan (26 December 2006, depth: 44 km, ML = 7.0), Hengchun Peninsula active tectonics must be better constrained in order if possible to prevent major destructions in the near future.

Geomorphology and Kinematics of the Nobi-Ise Active Fault Zone, Central Japan: Implications for the kinematic growth of tectonic landforms within an active thrust belt

NASA Astrophysics Data System (ADS)

Ishiyama, T.; Mueller, K. J.; Togo, M.; Takemura, K.; Okada, A.

2002-12-01

We present structural models constrained by tectonic geomorphology, surface geologic mapping and high-resolution seismic reflection profiles to define the kinematic evolution and geometry of active fault-related folds along the Nobi-Ise active fault zone (NAFZ). The NAFZ is an active intraplate fault system in central Japan, and consists of a 110-km-long array of active, east-verging reverse faults. We focus on the northern half of the NAFZ, where we use the kinematic evolution of active fault-related folds to constrain rates of slip on underlying blind thrusts and the rate of contraction across the belt since early Quaternary time. Fluvial terraces folded across the east-dipping forelimb, and west-dipping backlimb of the frontal Kuwana anticline suggest that it grows above a stacked sequence of thin-skinned wedge thrusts. Numerous secondary, bedding-parallel thrusts also deform the terraces and are interpreted to form by flexural slip folding that acts to consume slip on the primary blind thrusts across synclinal axial surfaces. Late Holocene fold scarps formed in the floodplain of the Ibi River east of Kuwana anticline coincide with the projected surface trace of the east-vergent wedge thrust tip and indicate the structure has accommodated coseismic (?) kink-band migration of a fault-bend fold during a historic blind thrust earthquake in 1586. A topographic cross-section based on a detailed photogrammetric map suggests 111 m of uplift of ca. 50-80 ka fluvial terraces deposited across the forelimb. For a 35° thrust, this yields the minimum slip rate of 2.7-4.8 mm/yr on the deepest wedge thrust beneath Kuwana anticline. Kinematic analysis for the much larger thrust defined to the west (the Fumotomura fault) suggests that folding of fluvial terraces occurred by trishear fault-propagation folding above a more steeply-dipping (54°), basement-involved blind thrust that propagated upward from the base of the seismogenic crust (about 12 km). Pleistocene growth strata defined by tephra (ca. 1.6 Ma) suggest the Fumotomura fault slips at a rate of 0.7-0.9 mm/yr.

Improved alignment of the Hengchun Fault (southern Taiwan) based on fieldwork, structure-from-motion, shallow drilling, and levelling data

NASA Astrophysics Data System (ADS)

Giletycz, Slawomir Jack; Chang, Chung-Pai; Lin, Andrew Tien-Shun; Ching, Kuo-En; Shyu, J. Bruce H.

2017-11-01

The fault systems of Taiwan have been repeatedly studied over many decades. Still, new surveys consistently bring fresh insights into their mechanisms, activity and geological characteristics. The neotectonic map of Taiwan is under constant development. Although the most active areas manifest at the on-land boundary of the Philippine Sea Plate and Eurasia (a suture zone known as the Longitudinal Valley), and at the southwestern area of the Western Foothills, the fault systems affect the entire island. The Hengchun Peninsula represents the most recently emerged part of the Taiwan orogen. This narrow 20-25 km peninsula appears relatively aseismic. However, at the western flank the peninsula manifests tectonic activity along the Hengchun Fault. In this study, we surveyed the tectonic characteristics of the Hengchun Fault. Based on fieldwork, four years of monitoring fault displacement in conjunction with levelling data, core analysis, UAV surveys and mapping, we have re-evaluated the fault mechanisms as well as the geological formations of the hanging and footwall. We surveyed features that allowed us to modify the existing model of the fault in two ways: 1) correcting the location of the fault line in the southern area of the peninsula by moving it westwards about 800 m; 2) defining the lithostratigraphy of the hanging and footwall of the fault. A bathymetric map of the southern area of the Hengchun Peninsula obtained from the Atomic Energy Council that extends the fault trace offshore to the south distinctively matches our proposed fault line. These insights, coupled with crust-scale tomographic data from across the Manila accretionary system, form the basis of our opinion that the Hengchun Fault may play a major role in the tectonic evolution of the southern part of the Taiwan orogen.

Shallow Vs Structure Accross Hayward Fault Zone Inferred from Multichannel Analysis of Surface Waves (MASW)

NASA Astrophysics Data System (ADS)

Chan, J. H.; Richardson, I. S.; Strayer, L. M.; Catchings, R.; McEvilly, A.; Goldman, M.; Criley, C.; Sickler, R. R.

2017-12-01

The Hayward Fault Zone (HFZ) includes the Hayward fault (HF), as well as several named and unnamed subparallel, subsidiary faults to the east, among them the Quaternary-active Chabot Fault (CF), the Miller Creek Fault (MCF), and a heretofore unnamed fault, the Redwood Thrust Fault (RTF). With an ≥M6.0 recurrence interval of 130 y for the HF and the last major earthquake in 1868, the HFZ is a major seismic hazard in the San Francisco Bay Area, exacerbated by the many unknown and potentially active secondary faults of the HFZ. In 2016, researchers from California State University, East Bay, working in concert with the United States Geological Survey conducted the East Bay Seismic Investigation (EBSI). We deployed 296 RefTek RT125 (Texan) seismographs along a 15-km-long linear seismic profile across the HF, extending from the bay in San Leandro to the hills in Castro Valley. Two-channel seismographs were deployed at 100 m intervals to record P- and S-waves, and additional single-channel seismographs were deployed at 20 m intervals where the seismic line crossed mapped faults. The active-source survey consisted of 16 buried explosive shots located at approximately 1-km intervals along the seismic line. We used the Multichannel Analysis of Surfaces Waves (MASW) method to develop 2-D shear-wave velocity models across the CF, MCF, and RTF. Preliminary MASW analysis show areas of anomalously low S-wave velocities , indicating zones of reduced shear modulus, coincident with these three mapped faults; additional velocity anomalies coincide with unmapped faults within the HFZ. Such compliant zones likely correspond to heavily fractured rock surrounding the faults, where the shear modulus is expected to be low compared to the undeformed host rock.

The northwest trending north Boquerón Bay-Punta Montalva Fault Zone; A through going active fault system in southwestern Puerto Rico

USGS Publications Warehouse

Roig‐Silva, Coral Marie; Asencio, Eugenio; Joyce, James

2013-01-01

The North Boquerón Bay–Punta Montalva fault zone has been mapped crossing the Lajas Valley in southwest Puerto Rico. Identification of the fault was based upon detailed analysis of geophysical data, satellite images, and field mapping. The fault zone consists of a series of Cretaceous bedrock faults that reactivated and deformed Miocene limestone and Quaternary alluvial fan sediments. The fault zone is seismically active (local magnitude greater than 5.0) with numerous locally felt earthquakes. Focal mechanism solutions suggest strain partitioning with predominantly east–west left-lateral displacements with small normal faults striking mostly toward the northeast. Northeast-trending fractures and normal faults can be found in intermittent streams that cut through the Quaternary alluvial fan deposits along the southern margin of the Lajas Valley, an east–west-trending 30-km-long fault-controlled depression. Areas of preferred erosion within the alluvial fan trend toward the west-northwest parallel to the onland projection of the North Boquerón Bay fault. The North Boquerón Bay fault aligns with the Punta Montalva fault southeast of the Lajas Valley. Both faults show strong southward tilting of Miocene strata. On the western end, the Northern Boquerón Bay fault is covered with flat-lying Holocene sediments, whereas at the southern end the Punta Montalva fault shows left-lateral displacement of stream drainage on the order of a few hundred meters.

Contribution of Transverse Structures, Magma, and Crustal Fluids to Continental Rift Evolution: The East African Rift in Southern Kenya

NASA Astrophysics Data System (ADS)

Kattenhorn, S. A.; Muirhead, J.; Dindi, E.; Fischer, T. P.; Lee, H.; Ebinger, C. J.

2013-12-01

The Magadi rift in southern Kenya formed at ~7 Ma within Proterozoic rocks of the Mozambique orogenic belt, parallel to its contact with the Archean Tanzania craton. The rift is bounded to the west by the ~1600-m-high Nguruman border fault. The rift center is intensely dissected by normal faults, most of which offset ~1.4-0.8 Ma lavas. Current E-W extensional velocities are ~2-4 mm/yr. Published crustal tomography models from the rift center show narrow high velocity zones in the upper crust, interpreted as cooled magma intrusions. Local, surface-wave, and SKS-splitting measurements show a rift-parallel anisotropy interpreted to be the result of aligned melt zones in the lithosphere. Our field observations suggest that recent fault activity is concentrated at the rift center, consistent with the location of the 1998 seismic swarm that was associated with an inferred diking event. Fault zones are pervasively mineralized by calcite, likely from CO2-rich fluids. A system of fault-fed springs provides the sole fluid input for Lake Magadi in the deepest part of the basin. Many of these springs emanate from the Kordjya fault, a 50-km-long, NW-SE striking, transverse structure connecting a portion of the border fault system (the NW-oriented Lengitoto fault) to the current locus of strain and magmatism at the rift center. Sampled springs are warm (44.4°C) and alkaline (pH=10). Dissolved gas data (mainly N2-Ar-He) suggests two-component mixing (mantle and air), possibly indicating that fluids are delivered into the fault zone from deep sources, consistent with a dominant role of magmatism to the focusing of strain at the rift center. The Kordjya fault has developed prominent fault scarps (~150 m high) despite being oblique to the dominant ~N-S fault fabric, and has utilized an en echelon alignment of N-S faults to accommodate its motion. These N-S faults show evidence of sinistral-oblique motion and imply a bookshelf style of faulting to accommodate dextral-oblique motion along the Kordjya fault. Fault relationships imply that the NW-SE transverse structures represent recent activity in the rift, and have locally tilted Late Pleistocene sediments. Given the abundance of N-S striking faults in the rift, the tendency for fault activity along transverse features suggests a change in the rifting driving forces that are likely the result of an interplay between strain localization at the rift center, inherited crustal fabric (NW structures in the Mozambique belt), a possible counterclockwise rotation of stress related to interacting rift segments in southern Kenya, and an active hydrothermal fluid regime that facilitates faulting. By connecting the Lengitoto fault to the rift center, the Kordjya fault has effectively caused the Magadi rift to bypass the Nguruman border fault, which has been rendered inactive and thus no longer a contributor to the rifting process.

Constraining slip rates and spacings for active normal faults

NASA Astrophysics Data System (ADS)

Cowie, Patience A.; Roberts, Gerald P.

2001-12-01

Numerous observations of extensional provinces indicate that neighbouring faults commonly slip at different rates and, moreover, may be active over different time intervals. These published observations include variations in slip rate measured along-strike of a fault array or fault zone, as well as significant across-strike differences in the timing and rates of movement on faults that have a similar orientation with respect to the regional stress field. Here we review published examples from the western USA, the North Sea, and central Greece, and present new data from the Italian Apennines that support the idea that such variations are systematic and thus to some extent predictable. The basis for the prediction is that: (1) the way in which a fault grows is fundamentally controlled by the ratio of maximum displacement to length, and (2) the regional strain rate must remain approximately constant through time. We show how data on fault lengths and displacements can be used to model the observed patterns of long-term slip rate where measured values are sparse. Specifically, we estimate the magnitude of spatial variation in slip rate along-strike and relate it to the across-strike spacing between active faults.

Holocene faulting in the Bellingham forearc basin: upper-plate deformation at the northern end of the Cascadia subduction zone

USGS Publications Warehouse

Kelsey, Harvey M.; Sherrod, Brian L.; Blakely, Richard J.; Haugerud, Ralph A.

2013-01-01

The northern Cascadia forearc takes up most of the strain transmitted northward via the Oregon Coast block from the northward-migrating Sierra Nevada block. The north-south contractional strain in the forearc manifests in upper-plate faults active during the Holocene, the northern-most components of which are faults within the Bellingham Basin. The Bellingham Basin is the northern of four basins of the actively deforming northern Cascadia forearc. A set of Holocene faults, Drayton Harbor, Birch Bay, and Sandy Point faults, occur within the Bellingham Basin and can be traced from onshore to offshore using a combination of aeromagnetic lineaments, paleoseismic investigations and scarps identified using LiDAR imagery. With the recognition of such Holocene faults, the northernmost margin of the actively deforming Cascadia forearc extends 60 km north of the previously recognized limit of Holocene forearc deformation. Although to date no Holocene faults are recognized at the northern boundary of the Bellingham Basin, which is 15 km north of the international border, there is no compelling tectonic reason to expect that Holocene faults are limited to south of the international border.

A 13 km Long Paleoseismological Trench in Western Germany

NASA Astrophysics Data System (ADS)

Grützner, C. H.; Reicherter, K.; Winandy, J.

2012-04-01

The expansion of an open pit lignite mine in this area makes it necessary to translocate one of Germany's most frequented, E-W trending highways for a length of 13 km during the next months and years. By this occasion, one of the largest faults of the Lower Rhine Embayment (LRE), the Rurrand Fault, was already cut in 2010. We applied geological mapping and surface-near geophysical techniques for investigating this possible candidate for the 1756 Düren earthquake (M>6; and considered as the strongest historical earthquake in Germany), and found clear hints for recent active faulting. The LRE in western Germany is one of the seismically most active areas in Central Europe. Earthquakes stronger than M6 have been documented by paleoseismological and archeoseismological investigations and written sources. Instrumental seismicity reached ML5.9 (Mw5.4; April 13th, 1992) in this densely populated area with alone nearby Cologne having more than one million inhabitants. Active faults trend NW-SE in a horst-graben system, parallel to the rivers Rhine and Rur. Recent studies reported that active faults in the study area are characterized by recurrence periods in the order of tens of ka. Those faults in western Germany are often not visible in the field due to relatively high erosion rates and therefore, the seismic hazard might be underestimated. The ongoing highway construction works will cut more (active) faults. We expect at least eight already mapped faults to be cut by the earth works, some of which capable of causing damaging earthquakes judging from their mere length. The construction work is a unique opportunity for paleoseismological investigations at already known, but yet unstudied faults. We hope to gather additional data for an improvement of seismic hazard estimations in Western Germany.

Transform fault earthquakes in the North Atlantic: Source mechanisms and depth of faulting

NASA Technical Reports Server (NTRS)

Bergman, Eric A.; Solomon, Sean C.

1987-01-01

The centroid depths and source mechanisms of 12 large earthquakes on transform faults of the northern Mid-Atlantic Ridge were determined from an inversion of long-period body waveforms. The earthquakes occurred on the Gibbs, Oceanographer, Hayes, Kane, 15 deg 20 min, and Vema transforms. The depth extent of faulting during each earthquake was estimated from the centroid depth and the fault width. The source mechanisms for all events in this study display the strike slip motion expected for transform fault earthquakes; slip vector azimuths agree to 2 to 3 deg of the local strike of the zone of active faulting. The only anomalies in mechanism were for two earthquakes near the western end of the Vema transform which occurred on significantly nonvertical fault planes. Secondary faulting, occurring either precursory to or near the end of the main episode of strike-slip rupture, was observed for 5 of the 12 earthquakes. For three events the secondary faulting was characterized by reverse motion on fault planes striking oblique to the trend of the transform. In all three cases, the site of secondary reverse faulting is near a compression jog in the current trace of the active transform fault zone. No evidence was found to support the conclusions of Engeln, Wiens, and Stein that oceanic transform faults in general are either hotter than expected from current thermal models or weaker than normal oceanic lithosphere.

Preliminary Studies of the Structural Characteristics of the Lubao Fault using 2D High Resolution Shallow Seismic Reflection Profile

NASA Astrophysics Data System (ADS)

Bonus, A. A. B.; Lagmay, A. M. A.; Rodolfo, K. S.

2016-12-01

The Lubao fault, located in the province of Pampanga, Philippines, is part of the Bataan Volcanic Arc Complex (BVAC). Active faults within and around the BVAC include the East Zambales and Iba faults; according to the official active faults map of the Philippine Institute of Volcanology and Seismology (PHIVOLCS) there are no other existing active faults in the area. The Lubao Fault distinctly separates wetlands to the northeast and dry alluvial plains to the northwest of Manila Bay. Long term subsidence and high sedimentation rates were observed in the fault and over the past 1.5 thousand years, the northeastern block has dropped 3.5 meters. Along the southwest flank of Mount Natib, tectonic structures were identified using surface mapping and remote sensing. The Persistent Scattering Interferometric Synthetic Aperture Radar (PSInSAR) data results of Eco et al. in 2015 shows uplifts and subsidence in the BVAC area delineating the Lubao Fault. A 480-meter seismic reflection line was laid down perpendicular to the fault with a recording system consisting of 48 channels of Geometrics geophones spaced 10 meters apart. Acquired data were processed using the standard seismic reflection processing sequence by Yilmaz 2001. This preliminary study produced a high resolution subsurface profile of the Lubao fault in the village of San Rafael, Lubao where it is well manifested. The velocity model integrated by stratigraphic data of drilled core shows subsurface lithology. The depth converted profile reveals clear structures and dipping segments which indicates a history of movement along the Lubao fault. Discontinuity of reflectors, either offsets or breaks, are considered structures along the subsurface of the study area. Additional structural mapping and seismic lines along the projected fault are planned in the future to further detail the characteristics of the Lubao Fault. The surface observations made by other researchers coupled with the subsurface seismic profile mapping of this study hopes to clearly delineate and characterize the Lubao Fault.

Probabilistic seismic hazard study based on active fault and finite element geodynamic models

NASA Astrophysics Data System (ADS)

Kastelic, Vanja; Carafa, Michele M. C.; Visini, Francesco

2016-04-01

We present a probabilistic seismic hazard analysis (PSHA) that is exclusively based on active faults and geodynamic finite element input models whereas seismic catalogues were used only in a posterior comparison. We applied the developed model in the External Dinarides, a slow deforming thrust-and-fold belt at the contact between Adria and Eurasia.. is the Our method consists of establishing s two earthquake rupture forecast models: (i) a geological active fault input (GEO) model and, (ii) a finite element (FEM) model. The GEO model is based on active fault database that provides information on fault location and its geometric and kinematic parameters together with estimations on its slip rate. By default in this model all deformation is set to be released along the active faults. The FEM model is based on a numerical geodynamic model developed for the region of study. In this model the deformation is, besides along the active faults, released also in the volumetric continuum elements. From both models we calculated their corresponding activity rates, its earthquake rates and their final expected peak ground accelerations. We investigated both the source model and the earthquake model uncertainties by varying the main active fault and earthquake rate calculation parameters through constructing corresponding branches of the seismic hazard logic tree. Hazard maps and UHS curves have been produced for horizontal ground motion on bedrock conditions VS 30 ≥ 800 m/s), thereby not considering local site amplification effects. The hazard was computed over a 0.2° spaced grid considering 648 branches of the logic tree and the mean value of 10% probability of exceedance in 50 years hazard level, while the 5th and 95th percentiles were also computed to investigate the model limits. We conducted a sensitivity analysis to control which of the input parameters influence the final hazard results in which measure. The results of such comparison evidence the deformation model and with their internal variability together with the choice of the ground motion prediction equations (GMPEs) are the most influencing parameter. Both of these parameters have significan affect on the hazard results. Thus having good knowledge of the existence of active faults and their geometric and activity characteristics is of key importance. We also show that PSHA models based exclusively on active faults and geodynamic inputs, which are thus not dependent on past earthquake occurrences, provide a valid method for seismic hazard calculation.

Heterogeneity in friction strength of an active fault by incorporation of fragments of the surrounding host rock

NASA Astrophysics Data System (ADS)

Kato, Naoki; Hirono, Tetsuro

2016-07-01

To understand the correlation between the mesoscale structure and the frictional strength of an active fault, we performed a field investigation of the Atera fault at Tase, central Japan, and made laboratory-based determinations of its mineral assemblages and friction coefficients. The fault zone contains a light gray fault gouge, a brown fault gouge, and a black fault breccia. Samples of the two gouges contained large amounts of clay minerals such as smectite and had low friction coefficients of approximately 0.2-0.4 under the condition of 0.01 m s-1 slip velocity and 0.5-2.5 MP confining pressure, whereas the breccia contained large amounts of angular quartz and feldspar and had a friction coefficient of 0.7 under the same condition. Because the fault breccia closely resembles the granitic rock of the hangingwall in composition, texture, and friction coefficient, we interpret the breccia as having originated from this protolith. If the mechanical incorporation of wall rocks of high friction coefficient into fault zones is widespread at the mesoscale, it causes the heterogeneity in friction strength of fault zones and might contribute to the evolution of fault-zone architectures.

Fault recovery characteristics of the fault tolerant multi-processor

NASA Technical Reports Server (NTRS)

Padilla, Peter A.

1990-01-01

The fault handling performance of the fault tolerant multiprocessor (FTMP) was investigated. Fault handling errors detected during fault injection experiments were characterized. In these fault injection experiments, the FTMP disabled a working unit instead of the faulted unit once every 500 faults, on the average. System design weaknesses allow active faults to exercise a part of the fault management software that handles byzantine or lying faults. It is pointed out that these weak areas in the FTMP's design increase the probability that, for any hardware fault, a good LRU (line replaceable unit) is mistakenly disabled by the fault management software. It is concluded that fault injection can help detect and analyze the behavior of a system in the ultra-reliable regime. Although fault injection testing cannot be exhaustive, it has been demonstrated that it provides a unique capability to unmask problems and to characterize the behavior of a fault-tolerant system.

Paleo-earthquake Analysis from the Morphologic Features of Unconsolidated-sediment Fault Scarp: An Example from Dushanzi Thrust Fault in the Northern Tianshan, China

NASA Astrophysics Data System (ADS)

Wei, Z.; He, H.

2016-12-01

Fault scarp is important specific tectonic landform caused by surface-rupture earthquake. The morphology of the fault scarp in unconsolidated sediment could evolve in a predictable, time-dependent diffusion model. As a result, the investigation of fault-generated fault scarps is a prevalent technique used to study fault activity, geomorphic evolution, and the recurrence of faulting events. Addition to obtainment of cumulative displacement, gradient changes, i.e. slope breaks, in the morphology of fault scarps could indicate multiple rupture events along an active fault. In this study, we exacted a large set of densely spaced topographic profiles across fault scarp from LiDAR-derive DEM to detect subtle changes in the fault scarp geometry at the Dushanzi trust fault in the Northern Tianshan, China. Several slope breaks in topographic profiles can be identified, which may represent repeated rupture at the investigated fault. The number of paleo-earthquakes derived from our analysis is 4-3, well in agreement with the investigation results from the paleoseismological trenches. Statistical analysis results show that the scarp height of fault scarp with one slope break is 0.75±0.12 (mean value ±1 standard deviation) m representing the last incremental displacement during earthquakes; the height of fault scarp with two slope breaks is 1.86±0.32 m, and the height of fault scarp with three-four slope break is 6.45±1.44 m. Our approach enables us to obtain paleo-earthquake information from geomorphological analysis of fault scarps, and to assess the multiple rupture history of a complex fault system.

Active backstop faults in the Mentawai region of Sumatra, Indonesia, revealed by teleseismic broadband waveform modeling

NASA Astrophysics Data System (ADS)

Wang, Xin; Bradley, Kyle Edward; Wei, Shengji; Wu, Wenbo

2018-02-01

Two earthquake sequences that affected the Mentawai islands offshore of central Sumatra in 2005 (Mw 6.9) and 2009 (Mw 6.7) have been highlighted as evidence for active backthrusting of the Sumatran accretionary wedge. However, the geometry of the activated fault planes is not well resolved due to large uncertainties in the locations of the mainshocks and aftershocks. We refine the locations and focal mechanisms of medium size events (Mw > 4.5) of these two earthquake sequences through broadband waveform modeling. In addition to modeling the depth-phases for accurate centroid depths, we use teleseismic surface wave cross-correlation to precisely relocate the relative horizontal locations of the earthquakes. The refined catalog shows that the 2005 and 2009 "backthrust" sequences in Mentawai region actually occurred on steeply (∼60 degrees) landward-dipping faults (Masilo Fault Zone) that intersect the Sunda megathrust beneath the deepest part of the forearc basin, contradicting previous studies that inferred slip on a shallowly seaward-dipping backthrust. Static slip inversion on the newly-proposed fault fits the coseismic GPS offsets for the 2009 mainshock equally well as previous studies, but with a slip distribution more consistent with the mainshock centroid depth (∼20 km) constrained from teleseismic waveform inversion. Rupture of such steeply dipping reverse faults within the forearc crust is rare along the Sumatra-Java margin. We interpret these earthquakes as 'unsticking' of the Sumatran accretionary wedge along a backstop fault separating imbricated material from the stronger Sunda lithosphere. Alternatively, the reverse faults may have originated as pre-Miocene normal faults of the extended continental crust of the western Sunda margin. Our waveform modeling approach can be used to further refine global earthquake catalogs in order to clarify the geometries of active faults.

The aftershock signature of supershear earthquakes.

PubMed

Bouchon, Michel; Karabulut, Hayrullah

2008-06-06

Recent studies show that earthquake faults may rupture at speeds exceeding the shear wave velocity of rocks. This supershear rupture produces in the ground a seismic shock wave similar to the sonic boom produced by a supersonic airplane. This shock wave may increase the destruction caused by the earthquake. We report that supershear earthquakes are characterized by a specific pattern of aftershocks: The fault plane itself is remarkably quiet whereas aftershocks cluster off the fault, on secondary structures that are activated by the supershear rupture. The post-earthquake quiescence of the fault shows that friction is relatively uniform over supershear segments, whereas the activation of off-fault structures is explained by the shock wave radiation, which produces high stresses over a wide zone surrounding the fault.

Timing of activity of two fault systems on Mercury

NASA Astrophysics Data System (ADS)

Galluzzi, V.; Guzzetta, L.; Giacomini, L.; Ferranti, L.; Massironi, M.; Palumbo, P.

2015-10-01

Here we discuss about two fault systems found in the Victoria and Shakespeare quadrangles of Mercury. The two fault sets intersect each other and show probable evidence for two stages of deformation. The most prominent system is N-S oriented and encompasses several tens to hundreds of kilometers long and easily recognizable fault segments. The other system strikes NE- SW and encompasses mostly degraded and short fault segments. The structural framework of the studied area and the morphological appearance of the faults suggest that the second system is older than the first one. We intend to apply the buffered crater counting technique on both systems to make a quantitative study of their timing of activity that could confirm the already clear morphological evidence.

Lateralized Spatial and Object Memory Encoding in Entorhinal and Perirhinal Cortices

ERIC Educational Resources Information Center

Bellgowan, Patrick S. F.; Buffalo, Elizabeth A.; Bodurka, Jerzy; Martin, Alex

2009-01-01

The perirhinal and entorhinal cortices are critical components of the medial temporal lobe (MTL) declarative memory system. Study of their specific functions using blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging (fMRI), however, has suffered from severe magnetic susceptibility signal dropout resulting in poor…

Medial Temporal Lobe Memory in Childhood: Developmental Transitions

ERIC Educational Resources Information Center

Townsend, Elise L.; Richmond, Jenny L.; Vogel-Farley, Vanessa K.; Thomas, Kathleen

2010-01-01

The medial temporal lobes (MTL) support declarative memory and mature structurally and functionally during the postnatal years in humans. Although recent work has addressed the development of declarative memory in early childhood, less is known about continued development beyond this period of time. The purpose of this investigation was to explore…

The MTL Torsional Split-Hopkinson Bar

DTIC Science & Technology

1990-05-01

DATA 80 PLOT AGAGE@ 90 PLOT BGAGE@ 95 REM STORE DATA IN AN ASCII FILE 100 ASTORE AGAGE@,BGAGE@,’TBARDATA" 110 CLEAR ALL. 120 CLOSE 130 END 20 APPENDIX...6145 2 ATTN: DTIC-FDAC I Metals and Ceramics Information Center, Battelle Columbus Laboratories, 505 King Avenue, Columbus, OH 43201 Commander, Army

Ductile Alloy Encapsulated Ceramic Armor Development

DTIC Science & Technology

1990-01-01

ACCESSION NO. 3. RECIPIENT’S CATALOG NUMBER MTL TR 90-2 4. TITLE (and Subtitle) S. TYPE OF. REPORT & PERIOO COVERED Final Report - June 1987 DUCTILE ALLOY...Ronald Biederman of Worcester Polytechnic Institute and Dr. Gordon Chu for their valuable contributions to this work. Accession For NTIS GRA&I DTIC TAB

Map and database of Quaternary faults in Venezuela and its offshore regions

USGS Publications Warehouse

Audemard, F.A.; Machette, M.N.; Cox, J.W.; Dart, R.L.; Haller, K.M.

2000-01-01

As part of the International Lithosphere Program’s “World Map of Major Active Faults,” the U.S. Geological Survey is assisting in the compilation of a series of digital maps of Quaternary faults and folds in Western Hemisphere countries. The maps show the locations, ages, and activity rates of major earthquake-related features such as faults and fault-related folds. They are accompanied by databases that describe these features and document current information on their activity in the Quaternary. The project is a key part of the Global Seismic Hazards Assessment Program (ILP Project II-0) for the International Decade for Natural Hazard Disaster Reduction.The project is sponsored by the International Lithosphere Program and funded by the USGS’s National Earthquake Hazards Reduction Program. The primary elements of the project are general supervision and interpretation of geologic/tectonic information, data compilation and entry for fault catalog, database design and management, and digitization and manipulation of data in †ARCINFO. For the compilation of data, we engaged experts in Quaternary faulting, neotectonics, paleoseismology, and seismology.

Recently Active Traces of the Berryessa Fault, California: A Digital Database

USGS Publications Warehouse

Lienkaemper, James J.

2012-01-01

The purpose of this map is to show the location of and evidence for recent movement on active fault traces within the Berryessa section and parts of adjacent sections of the Green Valley Fault Zone, California. The location and recency of the mapped traces is primarily based on geomorphic expression of the fault as interpreted from large-scale 2010 aerial photography and from 2007 and 2011 0.5 and 1.0 meter bare-earth LiDAR imagery (that is, high-resolution topographic data). In a few places, evidence of fault creep and offset Holocene strata in trenches and natural exposures have confirmed the activity of some of these traces. This publication is formatted both as a digital database for use within a geographic information system (GIS) and for broader public access as map images that may be browsed on-line or download a summary map. The report text describes the types of scientific observations used to make the map, gives references pertaining to the fault and the evidence of faulting, and provides guidance for use of and limitations of the map.

Preliminary Monitoring of Soil gas Radon in Potentially Active Faults, San Sai District, Chiang Mai Province, Thailand

NASA Astrophysics Data System (ADS)

Pondthai, P.; Udphuay, S.

2013-05-01

The magnitude of 5.1 Mw earthquake occurred in San Sai District, Chiang Mai Province, Thailand in December 2006 was considered an uncommon event due to the fact that there was no statistical record of such significant earthquake in the area. Therefore the earthquake might have been associated with a potentially active fault zone within the area. The objective of this study is to measure soil gas radon across this unknown fault zone within the Chiang Mai Basin, northern Thailand. Two profiles traversing the expected fault zone of soil gas radon measurements have been monitored, using TASTRAK solid state track nuclear detectors (SSNTDs). Radon signals from three periods of measurement show a distinctive consistent spatial distribution pattern. Anomalous radon areas along the profiles are connected to fault locations previously interpreted from other geophysical survey results. The increased radon signal changes from the radon background level with the signal-to-background ratio above 3 are considered anomalous. Such pattern of radon anomaly supports the existence of the faults. The radon measurement, therefore is a powerful technique in mapping active fault zone.

Active faulting in the central Betic Cordillera (Spain): Palaeoseismological constraint of the surface-rupturing history of the Baza Fault (Central Betic Cordillera, Iberian Peninsula)

NASA Astrophysics Data System (ADS)

Castro, J.; Martin-Rojas, I.; Medina-Cascales, I.; García-Tortosa, F. J.; Alfaro, P.; Insua-Arévalo, J. M.

2018-06-01

This paper on the Baza Fault provides the first palaeoseismic data from trenches in the central sector of the Betic Cordillera (S Spain), one of the most tectonically active areas of the Iberian Peninsula. With the palaeoseismological data we constructed time-stratigraphic OxCal models that yield probability density functions (PDFs) of individual palaeoseismic event timing. We analysed PDF overlap to quantitatively correlate the walls and site events into a single earthquake chronology. We assembled a surface-rupturing history of the Baza Fault for the last ca. 45,000 years. We postulated six alternative surface rupturing histories including 8-9 fault-wide earthquakes. We calculated fault-wide earthquake recurrence intervals using Monte Carlo. This analysis yielded a 4750-5150 yr recurrence interval. Finally, compared our results with the results from empirical relationships. Our results will provide a basis for future analyses of more of other active normal faults in this region. Moreover, our results will be essential for improving earthquake-probability assessments in Spain, where palaeoseismic data are scarce.

Active faults newly identified in Pacific Northwest

NASA Astrophysics Data System (ADS)

Balcerak, Ernie

2012-05-01

The Bellingham Basin, which lies north of Seattle and south of Vancouver around the border between the United States and Canada in the northern part of the Cascadia subduction zone, is important for understanding the regional tectonic setting and current high rates of crustal deformation in the Pacific Northwest. Using a variety of new data, Kelsey et al. identified several active faults in the Bellingham Basin that had not been previously known. These faults lie more than 60 kilometers farther north of the previously recognized northern limit of active faulting in the area. The authors note that the newly recognized faults could produce earthquakes with magnitudes between 6 and 6.5 and thus should be considered in hazard assessments for the region. (Journal of Geophysical Reserch-Solid Earth, doi:10.1029/2011JB008816, 2012)

Using the 3D active fault model to estimate the surface deformation, a study on HsinChu area, Taiwan.

NASA Astrophysics Data System (ADS)

Lin, Y. K.; Ke, M. C.; Ke, S. S.

2016-12-01

An active fault is commonly considered to be active if they have moved one or more times in the last 10,000 years and likely to have another earthquake sometime in the future. The relationship between the fault reactivation and the surface deformation after the Chi-Chi earthquake (M=7.2) in 1999 has been concerned up to now. According to the investigations of well-known disastrous earthquakes in recent years, indicated that surface deformation is controlled by the 3D fault geometric shape. Because the surface deformation may cause dangerous damage to critical infrastructures, buildings, roads, power, water and gas lines etc. Therefore it's very important to make pre-disaster risk assessment via the 3D active fault model to decrease serious economic losses, people injuries and deaths caused by large earthquake. The approaches to build up the 3D active fault model can be categorized as (1) field investigation (2) digitized profile data and (3) build the 3D modeling. In this research, we tracked the location of the fault scarp in the field first, then combined the seismic profiles (had been balanced) and historical earthquake data to build the underground fault plane model by using SKUA-GOCAD program. Finally compared the results come from trishear model (written by Richard W. Allmendinger, 2012) and PFC-3D program (Itasca) and got the calculated range of the deformation area. By analysis of the surface deformation area made from Hsin-Chu Fault, we concluded the result the damage zone is approaching 68 286m, the magnitude is 6.43, the offset is 0.6m. base on that to estimate the population casualties, building damage by the M=6.43 earthquake in Hsin-Chu area, Taiwan. In the future, in order to be applied accurately on earthquake disaster prevention, we need to consider further the groundwater effect and the soil structure interaction inducing by faulting.

Late Quaternary paleoearthquakes along the northern segment of the Nantinghe fault on the southeastern margin of the Tibetan Plateau

NASA Astrophysics Data System (ADS)

Sun, Haoyue; He, Honglin; Wei, Zhanyu; Shi, Feng; Gao, Wei

2017-05-01

The strong earthquake behaviors of faults are significant for learning crustal deformation mechanisms and for assessing regional seismic risk. To date, faults that bound tectonic blocks have attracted considerable concern and many studies; however, scant attention has been paid to faults within blocks that can also host devastating earthquakes. The Nantinghe fault is a left-lateral strike-slip fault within the Southwestern Yunnan Block, and it slips at ∼4 mm/yr suggesting strong activity in the late Quaternary. Nevertheless, no earthquake greater than 6 has ever been recorded along it, except for the 1941 M ∼7 earthquake near the Myanmar-China border region. In contrast, many earthquakes have occurred in the near region, delineating a seismic gap near the Nantinghe fault. Although several studies have been conducted upon it, the activity of its northern segment is confusing, and whether this fault segment has loaded sufficient stress to fail remains debatable. Furthermore, previous work failed to conduct any paleoseismological studies bringing out great uncertainty in learning its activity and faulting behavior, as well as in assessing the regional seismic risk. To solve these problems, we mapped the fault traces utilizing high-resolution satellite images and aerial photographs, and conducted three paleoseismological trenches along the northern segment of the Nantinghe fault. The trench excavations revealed a ∼45,000-year incomplete paleoearthquake history and confirmed that this fault segment has been active since the late Pleistocene but was not ruptured during the 1941 earthquake. Additionally, at least five paleoearthquakes are identified with their respective age ranges of before 39,030 BCE; 38,500-37,220 BCE; 28,475-5445 BCE; 3535 BCE-800 CE; and 1320-1435 CE based on radiocarbon dating. Among the paleoearthquakes, the latest is suggested to have generated a surface rupture much longer than 14 km with a magnitude likely up to Ms 7.0. Furthermore, based on the elapsed time since the latest paleoearthquake and the sinistral slip rate along the fault, it is proposed that the northern segment of the Nantinghe fault has accumulated a seismic energy equivalent to Ms 7.0, and it is in a high seismic risk along this fault segment and in the neighboring area.

Active Tectonics of Himalayan Faults/Thrusts System in Northern India on the basis of recent & Paleo earthquake Studies

NASA Astrophysics Data System (ADS)

Kumar, S.; Biswal, S.; Parija, M. P.

2016-12-01

The Himalaya overrides the Indian plate along a decollement fault, referred as the Main Himalayan Thrust (MHT). The 2400 km long Himalayan mountain arc in the northern boundary of the Indian sub-continent is one of the most seismically active regions of the world. The Himalayan Frontal Thrust (HFT) is characterized by an abrupt physiographic and tectonic break between the Himalayan front and the Indo-Gangetic plain. The HFT represents the southern surface expression of the MHT on the Himalayan front. The tectonic zone between the Main Boundary Thrust (MBT) and the HFT encompasses the Himalayan Frontal Fault System (HFFS). The zone indicates late Quaternary-Holocene active deformation. Late Quaternary intramontane basin of Dehradun flanked to the south by the Mohand anticline lies between the MBT and the HFT in Garhwal Sub Himalaya. Slip rate 13-15 mm/yr has been estimated on the HFT based on uplifted strath terrace on the Himalyan front (Wesnousky et al. 2006). An out of sequence active fault, Bhauwala Thrust (BT), is observed between the HFT and the MBT. The Himalayan Frontal Fault System includes MBT, BT, HFT and PF active fault structures (Thakur, 2013). The HFFS structures were developed analogous to proto-thrusts in subduction zone, suggesting that the plate boundary is not a single structure, but series of structures across strike. Seismicity recorded by WIHG shows a concentrated belt of seismic events located in the Main Central Thrust Zone and the physiographic transition zone between the Higher and Lesser Himalaya. However, there is quiescence in the Himalayan frontal zone where surface rupture and active faults are reported. GPS measurements indicate the segment between the southern extent of microseismicity zone and the HFT is locked. The great earthquake originating in the locked segment rupture the plate boundary fault and propagate to the Himalaya front and are registered as surface rupture reactivating the fault in the HFFS.

Geology along the Fairweather-Queen Charlotte fault system off southeast Alaska and British Columbia from GLORIA images and seismic-reflection data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bruns, T.R.; Carlson, P.R.; Stevenson, A.J.

1990-06-01

GLORIA images collected in 1989 along southeast Alaska and British Columbia strikingly show the active trace of the Fairweather-Queen Charlotte transform fault system beneath the outer shelf and slope; seismic-reflection data are used to track the fault system across the continental shelf where GLORIA data are not available. From Cross Sound to Chatham Strait, the fault system is comprised of two sets of subparallel fault traces separated by 3 to 6 km. The fault system crosses the shelf from Icy Point to south of Yakobi Valley, then follows the shelf edge to Chatham Strait. Between Chatham Strait and Dixon Entrance,more » a single, sharply defined active fault trace underlies the upper and middle slope. This fault segment is bounded on the seaward side by a high, midslope ridge and by lower slope Quaternary( ) anticlines up to 35 km wide. Southeast of Dixon Entrance, the active fault trace trends back onto the outer shelf until midway along the Queen Charlotte Islands, then cuts back to and stays at midslope to the Tuzo Wilson Knolls south of the Queen Charlotte Islands. The fault steps westward at Tuzo Wilson Knolls, which are likely part of a spreading ridge segment. Major deep-sea fans along southeast Alaska show a southeastward age progression from older to younger and record both point source deposition at Chatham Strait and Dixon Entrance and subsequent (Quaternary ) offset along the fault system. Subsidence of ocean plate now adjacent to the Chatham Strait-Dixon Entrance fault segment initiated development of both Mukluk and Horizon Channels.« less

Multidisciplinary approach for fault detection: Integration of PS-InSAR, geomorphological, stratigraphic and structural data in the Venafro intermontane basin (Central-Southern Apennines, Italy)

NASA Astrophysics Data System (ADS)

Amato, Vincenzo; Aucelli, Pietro P. C.; Bellucci Sessa, Eliana; Cesarano, Massimo; Incontri, Pietro; Pappone, Gerardo; Valente, Ettore; Vilardo, Giuseppe

2017-04-01

A multidisciplinary methodology, integrating stratigraphic, geomorphological and structural data, combined with GIS-aided analysis and PS-InSAR interferometric data, was applied to characterize the relationships between ground deformations and the stratigraphic and the morphostructural setting of the Venafro intermontane basin. This basin is a morphostructural depression related to NW-SE and NE-SW oriented high angle normal faults bordering and crossing it. In particular, a well-known active fault crossing the plain is the Aquae Juliae Fault, whose recent activity is evidenced by archeoseismological data. The approach applied here reveals new evidence of possible faulting, acting during the Lower to Upper Pleistocene, which has driven the morphotectonic and the environmental evolution of the basin. In particular, the tectonic setting emerging from this study highlights the influence of the NW-SE oriented extensional phase during the late Lower Pleistocene - early Middle Pleistocene, in the generation of NE-SW trending, SE dipping, high-angle faults and NW-SE trending, high-angle transtensive faults. This phase has been followed by a NE-SW extensional one, responsible for the formation of NW-SE trending, both NW and SE dipping, high-angle normal faults, and the reactivation of the oldest NE-SW oriented structures. These NW-SE trending normal faults include the Aquae Juliae Fault and a new one, unknown until now, crossing the plain between the Venafro village and the Colle Cupone Mt. (hereinafter named the Venafro-Colle Cupone Fault, VCCF). This fault has controlled deposition of the youngest sedimentary units (late Middle Pleistocene to late Upper Pleistocene) suggesting its recent activity and it is well constrained by PS-InSAR data, as testified by the increase of the subsidence rate in the hanging wall block.

New Geologic Data on the Seismic Risks of the Most Dangerous Fault on Shore in Central Japan, the Itoigawa-Shizuoka Tectonic Line Active Fault System

NASA Astrophysics Data System (ADS)

Okumura, K.; Kondo, H.; Toda, S.; Takada, K.; Kinoshita, H.

2006-12-01

Ten years have past since the first official assessment of the long-term seismic risks of the Itoigawa-Shizuoka tectonic line active fault system (ISTL) in 1996. The disaster caused by the1995 Kobe (Hyogo-ken-Nanbu) earthquake urged the Japanese government to initiated a national project to assess the long-term seismic risks of on-shore active faults using geologic information. ISTL was the first target of the 98 significant faults and the probability of a M7 to M8 event turned out to be the highest among them. After the 10 years of continued efforts to understand the ISTL, now it is getting ready to revise the assessment. Fault mapping and segmentation: The most active segment of the Gofukuji fault (~1 cm/yr left-lateral strike slip, R=500~800 yrs.) had been maped only for less than 10 km. Adjacent segments were much less active. This large slip on such a short segment was contradictory. However, detailed topographic study including Lidar survey revealed the length of the Gofukuji fault to be 25 km or more. High slip rate with frequent earthquakes may be restricted to the Gofukuji fault while the 1996 assessment modeled frequent >100 km rupture scenario. The geometry of the fault is controversial especially on the left-lateral strike-slip section of the ISTL. There are two models of high-angle Middel ISTL and low-angle Middle ISTL with slip partitioning. However, all geomorphic and shallow geologic data supports high-angle almost pure strike slip on the faults in the Middle ISTL. CRIEPI's 3- dimensional trenching in several sites as well as the previous results clearly demonstrated repeated pure strike-slip offset during past a few events. In Middle ISTL, there is no evidence of recent activity of pre-existing low-angle thrust faults that are inferred to be active from shallow seismic survey. Separation of high (~3000 m) mountain ranges and low (<1000 m) basin floor requires significant dip-slip component, but basin-fill sediments and geology of the range do not need vertical separation along the Gofukuji fault. The key issue for the time-dependent assessment of the Northern ISTL (east dipping reverse faults) was the lack of reliable time constraints on past earthquakes. In order to solve this problem, we have carried out intensive geoslicer and boring survey of buried faults at Kisaki. Along a 35 m long transect, we collected total 150 m complete cores in 9 geoslicer and 5 all-core boring holes. This is one of the most intensive surveys of a buried fault scarp under the water table. About 20 m vertical offset of 6000-year-old buried A-horizon is now underlain by a series of flood deposits, point bars and over-bank sediments, that intercalates 2 or 3 faulting events. The precise timing and offset of each event recorded in the section will be the critical evidence to tell the synchroneity of earthquakes in the Northern ISTL and the Middle ISTL. The magnitude of the coming event on ISTL is the most important but uncertain parameter of the 1996 assessment. The structural and paleoseimological information will present better constraints on the earthquake.

Ground Deformation near active faults in the Kinki district, southwest Japan, detected by InSAR

NASA Astrophysics Data System (ADS)

Hashimoto, M.; Ozawa, T.

2016-12-01

The Kinki district, southwest Japan, consists of ranges and plains between which active faults reside. The Osaka plain is in the middle of this district and is surrounded by the Rokko, Arima-Takatsuki, Ikoma, Kongo and Median Tectonic Line fault zones in the clockwise order. These faults are considered to be capable to generate earthquakes of larger magnitude than 7. The 1995 Kobe earthquake is the most recent activity of the Rokko fault (NE-SW trending dextral fault). Therefore the monitoring of ground deformation with high spatial resolution is essential to evaluate seismic hazards in this area. We collected and analyzed available SAR images such as ERS-1/2, Envisat, JERS-1, TerraSAR-X, ALOS/PALSAR and ALOS-2/PALSAR-2 to reveal ground deformation during these 20 years. We made DInSAR and PSInSAR analyses of these images using ASTER-GDEM ver.2. We detected three spots of subsidence along the Arima-Takatsuki fault (ENE-WSW trending dextral fault, east neighbor of the Rokko fault) after the Kobe earthquake, which continued up to 2010. Two of them started right after the Kobe earthquake, while the easternmost one was observed after 2000. However, we did not find them in the interferograms of ALOS-2/PALSAR-2 acquired during 2014 - 2016. Marginal uplift was recognized along the eastern part of the Rokko fault. PS-InSAR results of ALOS/PALSAR also revealed slight uplift north of the Rokko Mountain that uplift by 20 cm coseismically. These observations suggest that the Rokko Mountain might have uplifted during the postseismic period. We found subsidence on the eastern frank of the Kongo Mountain, where the Kongo fault (N-S trending reverse fault) exits. In the southern neighbor of the Median Tectonic Line (ENE-WSW trending dextral fault), uplift of > 5 mm/yr was found by Envisat and ALOS/PALSAR images. This area is shifted westward by 4 mm/yr as well. Since this area is located east of a seismically active area in the northwestern Wakayama prefecture, this deformation may generate E-W compressive stress, which is dominant in focal mechanism of most earthquakes, in the epicentral area.

Intraplate seismicity along the Gedi Fault in Kachchh rift basin of western India

NASA Astrophysics Data System (ADS)

Joshi, Vishwa; Rastogi, B. K.; Kumar, Santosh

2017-11-01

The Kachchh rift basin is located on the western continental margin of India and has a history of experiencing large to moderate intraplate earthquakes with M ≥ 5. During the past two centuries, two large earthquakes of Mw 7.8 (1819) and Mw 7.7 (2001) have occurred in the Kachchh region, the latter with an epicenter near Bhuj. The aftershock activity of the 2001 Bhuj earthquake is still ongoing with migration of seismicity. Initially, epicenters migrated towards the east and northeast within the Kachchh region but, since 2007, it has also migrated to the south. The triggered faults are mostly within 100 km and some up to 200 km distance from the epicentral area of the mainshock. Most of these faults are trending in E-W direction, and some are transverse. It was noticed that some faults generate earthquakes down to the Moho depth whereas some faults show earthquake activity within the upper crustal volume. The Gedi Fault, situated about 50 km northeast of the 2001 mainshock epicenter, triggered the largest earthquake of Mw 5.6 in 2006. We have carried out detailed seismological studies to evaluate the seismic potential of the Gedi Fault. We have relocated 331 earthquakes by HypoDD to improve upon location errors. Further, the relocated events are used to estimate the b value, p value, and fractal correlation dimension Dc of the fault zone. The present study indicates that all the events along the Gedi Fault are shallow in nature, with focal depths less than 20 km. The estimated b value shows that the Gedi aftershock sequence could be classified as Mogi's type 2 sequence, and the p value suggests a relatively slow decay of aftershocks. The fault plane solutions of some selected events of Mw > 3.5 are examined, and activeness of the Gedi Fault is assessed from the results of active fault studies as well as GPS and InSAR results. All these results are critically examined to evaluate the material properties and seismic potential of the Gedi Fault that may be useful for seismic hazard assessment in the region.

Slip Rates of Main Active Fault Zones Through Turkey Inferred From GPS Observations

NASA Astrophysics Data System (ADS)

Ozener, H.; Aktug, B.; Dogru, A.; Tasci, L.; Acar, M.; Emre, O.; Yilmaz, O.; Turgut, B.; Halicioglu, K.; Sabuncu, A.; Bal, O.; Eraslan, A.

2015-12-01

Active Fault Map of Turkey was revised and published by General Directorate of Mineral Research and Exploration in 2012. This map reveals that there are about 500 faults can generate earthquakes.In order to understand the earthquake potential of these faults, it is needed to determine the slip rates. Although many regional and local studies were performed in the past, the slip rates of the active faults in Turkey have not been determined. In this study, the block modelling, which is the most common method to produce slip rates, will be done. GPS velocities required for block modeling is being compiled from the published studies and the raw data provided then velocity field is combined. To form a homogeneous velocity field, different stochastic models will be used and the optimal velocity field will be achieved. In literature, GPS site velocities, which are computed for different purposes and published, are combined globally and this combined velocity field are used in the analysis of strain accumulation. It is also aimed to develop optimal stochastic models to combine the velocity data. Real time, survey mode and published GPS observations is being combined in this study. We also perform new GPS observations. Furthermore, micro blocks and main fault zones from Active Fault Map Turkey will be determined and homogeneous velocity field will be used to infer slip rates of these active faults. Here, we present the result of first year of the study. This study is being supported by THE SCIENTIFIC AND TECHNOLOGICAL RESEARCH COUNCIL OF TURKEY (TUBITAK)-CAYDAG with grant no. 113Y430.

Map and Database of Probable and Possible Quaternary Faults in Afghanistan

USGS Publications Warehouse

Ruleman, C.A.; Crone, A.J.; Machette, M.N.; Haller, K.M.; Rukstales, K.S.

2007-01-01

The U.S. Geological Survey (USGS) with support from the U.S. Agency for International Development (USAID) mission in Afghanistan, has prepared a digital map showing the distribution of probable and suspected Quaternary faults in Afghanistan. This map is a key component of a broader effort to assess and map the country's seismic hazards. Our analyses of remote-sensing imagery reveal a complex array of tectonic features that we interpret to be probable and possible active faults within the country and in the surrounding border region. In our compilation, we have mapped previously recognized active faults in greater detail, and have categorized individual features based on their geomorphic expression. We assigned mapped features to eight newly defined domains, each of which contains features that appear to have similar styles of deformation. The styles of deformation associated with each domain provide insight into the kinematics of the modern tectonism, and define a tectonic framework that helps constrain deformational models of the Alpine-Himalayan orogenic belt. The modern fault movements, deformation, and earthquakes in Afghanistan are driven by the collision between the northward-moving Indian subcontinent and Eurasia. The patterns of probable and possible Quaternary faults generally show that much of the modern tectonic activity is related to transfer of plate-boundary deformation across the country. The left-lateral, strike-slip Chaman fault in southeastern Afghanistan probably has the highest slip rate of any fault in the country; to the north, this slip is distributed onto several fault systems. At the southern margin of the Kabul block, the style of faulting changes from mainly strike-slip motion associated with the boundary between the Indian and Eurasian plates, to transpressional and transtensional faulting. North and northeast of the Kabul block, we recognized a complex pattern of potentially active strike-slip, thrust, and normal faults that form a conjugate shear system in a transpressional region of the Trans-Himalayan orogenic belt. The general patterns and orientations of faults and the styles of deformation that we interpret from the imagery are consistent with the styles of faulting determined from focal mechanisms of historical earthquakes. Northwest-trending strike-slip fault zones are cut and displaced by younger, southeast-verging thrust faults; these relations define the interaction between northwest-southeast-oriented contraction and northwest-directed extrusion in the western Himalaya, Pamir, and Hindu Kush regions. Transpression extends into north-central Afghanistan where north-verging contraction along the east-west-trending Alburz-Marmul fault system interacts with northwest-trending strike-slip faults. Pressure ridges related to thrust faulting and extensional basins bounded by normal faults are located at major stepovers in these northwest-trending strike-slip systems. In contrast, young faulting in central and western Afghanistan indicates that the deformation is dominated by extension where strike-slip fault zones transition into regions of normal faults. In addition to these initial observations, our digital map and database provide a foundation that can be expanded, complemented, and modified as future investigations provide more detailed information about the location, characteristics, and history of movement on Quaternary faults in Afghanistan.

Geomorphology, kinematic history, and earthquake behavior of the active Kuwana wedge thrust anticline, central Japan

NASA Astrophysics Data System (ADS)

Ishiyama, Tatsuya; Mueller, Karl; Togo, Masami; Okada, Atsumasa; Takemura, Keiji

2004-12-01

We combine surface mapping of fault and fold scarps that deform late Quaternary alluvial strata with interpretation of a high-resolution seismic reflection profile to develop a kinematic model and determine fault slip rates for an active blind wedge thrust system that underlies Kuwana anticline in central Japan. Surface fold scarps on Kuwana anticline are closely correlated with narrow fold limbs and angular hinges on the seismic profile that suggest at least ˜1.3 km of fault slip completely consumed by folding in the upper 4 km of the crust. The close coincidence and kinematic link between folded terraces and the underlying thrust geometry indicate that Kuwana anticline has accommodated slip at an average rate of 2.2 ± 0.5 mm/yr on a 27°, west dipping thrust fault since early-middle Pleistocene time. In contrast to classical fault bend folds the fault slip budget in the stacked wedge thrusts also indicates that (1) the fault tip propagated upward at a low rate relative to the accrual of fault slip and (2) fault slip is partly absorbed by numerous bedding plane flexural-slip faults above the tips of wedge thrusts. An historic earthquake that occurred on the Kuwana blind thrust system possibly in A.D. 1586 is shown to have produced coseismic surface deformation above the doubly vergent wedge tip. Structural analyses of Kuwana anticline coupled with tectonic geomorphology at 103-105 years timescales illustrate the significance of active folds as indicators of slip on underlying blind thrust faults and thus their otherwise inaccessible seismic hazards.

Alternative interpretation for the active zones of Cuba

NASA Astrophysics Data System (ADS)

Rodríguez, Mario Octavio Cotilla

2014-11-01

An alternative explanation to the seismoactivity of Cuban faults is presented. The model is a consequence of the interaction between Caribbean and North American plates. It is made with 12 geodynamic cells form by a set of 13 active faults and their 14 areas of intersection. These cells are recognized morpho-structural blocks. The area between Eastern Matanzas and Western Cauto-Nipe is excluded because of the low level of seismic information. Cuba has two types of seismogenetic structures: faults and intersection of faults.

Tectonic geomorphology and paleoseismology of strike-slip faults in Jamaica: Implications for distribution of strain and seismic hazard along the southern edge of the Gonave microplate

NASA Astrophysics Data System (ADS)

Koehler, R. D.; Mann, P.; Brown, L. A.

2009-12-01

The east-west, left lateral strike-slip fault system forming the southern edge of the Gonave microplate crosses the110-km-long and 70-km-wide island of Jamaica. GPS measurements in the northeastern Caribbean are supportive of the microplate interpretation and indicate that ~ half of the Caribbean-North America left-lateral plate motion (8-14 mm/yr) is carried by the Plantain Garden (PGFZ) and associated faults in Jamaica. We performed Neotectonic mapping of the Plantain Garden fault along the southern rangefront of the Blue Mountains and conducted a paleoseismic study of the fault at Morant River. Between Holland Bay and Morant River, the fault is characterized by a steep, faceted, linear mountain front, prominent linear valleys and depressions, shutter ridges, and springs. At the eastern end of the island, the PGFZ is characterized by a left-stepping fault geometry that includes a major, active hot spring. The river cut exposure at Morant River exposes a 1.5-m-wide, sub-vertical fault zone juxtaposing sheared alluvium and faulted Cretaceous basement rocks. This section is overlain by an, unfaulted 3-m-thick fluvial terrace inset into a late Pleistocene terrace that is culturally modified. Upward fault terminations indicate the occurrence of three paleoearthquakes that occurred prior to deposition of the flat lying inset terrace around 341-628 cal yr BP. At this time, our radiocarbon results suggest that we can rule out the PGFZ as the source of the 1907 Kingston earthquake 102 years ago, as well as, the 1692 event that destroyed Port Royal 317 years ago and produced a major landslide at Yallahs. Pending OSL ages will constrain the age of the penultimate and most recent ruptures. Gently to steeply dipping rocks as young as Pliocene exposed in roadcuts within the low coastal hills south of and parallel to the Plantain Garden fault may indicate active folding and blind thrust faulting. These structures are poorly characterized and may accommodate an unknown amount of oblique strain. Reconnaissance mapping was also performed along the South Coast fault in south-central Jamaica north of Portland Ridge, and along the Crawle River-Rio Minho fault near Frankfield in the Central Inlier. The absence of fault scarps or other tectonic geomorphic features across fluvial terraces of the Milk and Minho Rivers indicate that the South Coast fault has not been active in Holocene time. Left laterally offset streams, linear valleys, and saddles support active faulting along the east-west Crawle River-Rio Minho fault that is roughly collinear with the western extension of the Plantain Garden fault.

Wetland losses related to fault movement and hydrocarbon production, southeastern Texas coast

USGS Publications Warehouse

White, William A.; Morton, Robert A.

1997-01-01

Time series analyses of surface fault activity and nearby hydrocarbon production from the southeastern Texas coast show a high correlation among volume of produced fluids, timing of fault activation, rates of subsidence, and rates of wetland loss. Greater subsidence on the downthrown sides of faults contributes to more frequent flooding and generally wetter conditions, which are commonly reflected by changes in plant communities {e.g., Spartina patens to Spartina alterniflora) or progressive transformation of emergent vegetation to open water. Since the 1930s and 1950s, approximately 5,000 hectares of marsh habitat has been lost as a result of subsidence associated with faulting. Marsh- es have expanded locally along faults where hydrophytic vegetation has spread into former upland areas. Fault traces are linear to curvilinear and are visible because elevation differences across faults alter soil hydrology and vegetation. Fault lengths range from 1 to 13.4 km and average 3.8 km. Seventy-five percent of the faults visible on recent aerial photographs are not visible on photographs taken in the 1930's, indicating relatively recent fault movement. At least 80% of the surface faults correlate with extrapolated subsurface faults; the correlation increases to more than 90% when certain assumptions are made to compensate for mismatches in direction of displacement. Coastal wetlands loss in Texas associated with hydrocarbon extraction will likely increase where production in mature fields is prolonged without fiuid reinjection.

Palaeopermeability structure within fault-damage zones: A snap-shot from microfracture analyses in a strike-slip system

NASA Astrophysics Data System (ADS)

Gomila, Rodrigo; Arancibia, Gloria; Mitchell, Thomas M.; Cembrano, Jose M.; Faulkner, Daniel R.

2016-02-01

Understanding fault zone permeability and its spatial distribution allows the assessment of fluid-migration leading to precipitation of hydrothermal minerals. This work is aimed at unraveling the conditions and distribution of fluid transport properties in fault zones based on hydrothermally filled microfractures, which reflect the ''frozen-in'' instantaneous advective hydrothermal activity and record palaeopermeability conditions of the fault-fracture system. We studied the Jorgillo Fault, an exposed 20 km long, left-lateral strike-slip fault, which juxtaposes Jurassic gabbro against metadiorite belonging to the Atacama Fault System in northern Chile. Tracings of microfracture networks of 19 oriented thin sections from a 400 m long transect across the main fault trace was carried out to estimate the hydraulic properties of the low-strain fault damagezone, adjacent to the high-strain fault core, by assuming penny-shaped microfractures of constant radius and aperture within an anisotropic fracture system. Palaeopermeability values of 9.1*10-11 to 3.2*10-13 m2 in the gabbro and of 5.0*10-10 to 1.2*10-13 m2 in the metadiorite were determined, both decreasing perpendicularly away from the fault core. Fracture porosity values range from 40.00% to 0.28%. The Jorgillo Fault has acted as a left-lateral dilational fault-bend, generating large-scale dilation sites north of the JF during co-seismic activity.

Tectonic context of moderate to large historical earthquakes in the Lesser Antilles and mechanical coupling with volcanoes

NASA Astrophysics Data System (ADS)

Feuillet, Nathalie; Beauducel, FrançOis; Tapponnier, Paul

2011-10-01

The oblique convergence between North American and Caribbean plates is accommodated in a bookshelf faulting manner by active, oblique-normal faults in the northern part of the Lesser Antilles arc. In the last 20 years, two M > 6 earthquakes occurred along a large, arc parallel, en echelon fault system, the 16 March 1985 in Redonda and 21 November 2004 in Les Saintes. A better understanding of active faulting in this region permit us to review the location and magnitude of historical earthquakes by using a regional seismic attenuation law. Several others moderate earthquakes may have occurred along the en echelon fault system implying a strong seismic hazard along the arc. These faults control the effusion of volcanic products and some earthquakes seem to be correlated in time with volcanic unrest. Shallow earthquakes on intraplate faults induced normal stress and pressure changes around neighboring volcano and may have triggered volcanic activity. The Redonda earthquake could have initiated the 1995 eruption of Montserrat's Soufrière Hills by compressing its plumbing system. Conversely, pressure changes under the volcano increased Coulomb stress changes and brought some faults closer to failure, promoting seismicity. We also discuss the magnitude of the largest 11 January 1839 and 8 February 1843 megathrust interplate earthquakes. We calculate that they have increased the stress on some overriding intraplate faults and the extensional strain beneath several volcanoes. This may explain an increase of volcanic and seismic activity in the second half of the 19th century culminating with the devastating, 1902 Mount Pelée eruption.

Integrated geophysical investigations in a fault zone located on southwestern part of İzmir city, Western Anatolia, Turkey

NASA Astrophysics Data System (ADS)

Drahor, Mahmut G.; Berge, Meriç A.

2017-01-01

Integrated geophysical investigations consisting of joint application of various geophysical techniques have become a major tool of active tectonic investigations. The choice of integrated techniques depends on geological features, tectonic and fault characteristics of the study area, required resolution and penetration depth of used techniques and also financial supports. Therefore, fault geometry and offsets, sediment thickness and properties, features of folded strata and tectonic characteristics of near-surface sections of the subsurface could be thoroughly determined using integrated geophysical approaches. Although Ground Penetrating Radar (GPR), Electrical Resistivity Tomography (ERT) and Seismic Refraction Tomography (SRT) methods are commonly used in active tectonic investigations, other geophysical techniques will also contribute in obtaining of different properties in the complex geological environments of tectonically active sites. In this study, six different geophysical methods used to define faulting locations and characterizations around the study area. These are GPR, ERT, SRT, Very Low Frequency electromagnetic (VLF), magnetics and self-potential (SP). Overall integrated geophysical approaches used in this study gave us commonly important results about the near surface geological properties and faulting characteristics in the investigation area. After integrated interpretations of geophysical surveys, we determined an optimal trench location for paleoseismological studies. The main geological properties associated with faulting process obtained after trenching studies. In addition, geophysical results pointed out some indications concerning the active faulting mechanism in the area investigated. Consequently, the trenching studies indicate that the integrated approach of geophysical techniques applied on the fault problem reveals very useful and interpretative results in description of various properties of faulting zone in the investigation site.

Active transpressional tectonics in the Andean forearc of southern Peru quantified by 10Be surface exposure dating of an active fault scarp

NASA Astrophysics Data System (ADS)

Benavente, Carlos; Zerathe, Swann; Audin, Laurence; Hall, Sarah R.; Robert, Xavier; Delgado, Fabrizio; Carcaillet, Julien; Team, Aster

2017-09-01

Our understanding of the style and rate of Quaternary tectonic deformation in the forearc of the Central Andes is hampered by a lack of field observations and constraints on neotectonic structures. Here we present a detailed analysis of the Purgatorio fault, a recently recognized active fault located in the forearc of southern Peru. Based on field and remote sensing analysis (Pléiades DEM), we define the Purgatorio fault as a subvertical structure trending NW-SE to W-E along its 60 km length, connecting, on its eastern end, to the crustal Incapuquio Fault System. The Purgatorio fault accommodates right-lateral transpressional deformation, as shown by the numerous lateral and vertical plurimetric offsets recorded along strike. In particular, scarp with a 5 m cumulative throw is preserved and displays cobbles that are cut and covered by slickensides. Cosmogenic radionuclide exposure dating (10Be) of quartzite cobbles along the vertical fault scarp yields young exposure ages that can be bracketed between 0 to 6 ka, depending on the inheritance model that is applied. Our preferred scenario, which takes in account our geomorphic observations, implies at least two distinct rupture events, each associated with 3 and 2 m of vertical offset. These two events plausibly occurred during the last thousand years. Nevertheless, an interpretation invoking more tectonic events along the fault cannot be ruled out. This work affirms crustal deformation along active faults in the Andean forearc of southern Peru during the last thousand years.

Reverse fault growth and fault interaction with frictional interfaces: insights from analogue models

NASA Astrophysics Data System (ADS)

Bonanno, Emanuele; Bonini, Lorenzo; Basili, Roberto; Toscani, Giovanni; Seno, Silvio

2017-04-01

The association of faulting and folding is a common feature in mountain chains, fold-and-thrust belts, and accretionary wedges. Kinematic models are developed and widely used to explain a range of relationships between faulting and folding. However, these models may result not to be completely appropriate to explain shortening in mechanically heterogeneous rock bodies. Weak layers, bedding surfaces, or pre-existing faults placed ahead of a propagating fault tip may influence the fault propagation rate itself and the associated fold shape. In this work, we employed clay analogue models to investigate how mechanical discontinuities affect the propagation rate and the associated fold shape during the growth of reverse master faults. The simulated master faults dip at 30° and 45°, recalling the range of the most frequent dip angles for active reverse faults that occurs in nature. The mechanical discontinuities are simulated by pre-cutting the clay pack. For both experimental setups (30° and 45° dipping faults) we analyzed three different configurations: 1) isotropic, i.e. without precuts; 2) with one precut in the middle of the clay pack; and 3) with two evenly-spaced precuts. To test the repeatability of the processes and to have a statistically valid dataset we replicate each configuration three times. The experiments were monitored by collecting successive snapshots with a high-resolution camera pointing at the side of the model. The pictures were then processed using the Digital Image Correlation method (D.I.C.), in order to extract the displacement and shear-rate fields. These two quantities effectively show both the on-fault and off-fault deformation, indicating the activity along the newly-formed faults and whether and at what stage the discontinuities (precuts) are reactivated. To study the fault propagation and fold shape variability we marked the position of the fault tips and the fold profiles for every successive step of deformation. Then we compared precut models with isotropic models to evaluate the trends of variability. Our results indicate that the discontinuities are reactivated especially when the tip of the newly-formed fault is either below or connected to them. During the stage of maximum activity along the precut, the faults slow down or even stop their propagation. The fault propagation systematically resumes when the angle between the fault and the precut is about 90° (critical angle); only during this stage the fault crosses the precut. The reactivation of the discontinuities induces an increase of the apical angle of the fault-related fold and produces wider limbs compared to the isotropic reference experiments.

A review of recently active faults in Taiwan

USGS Publications Warehouse

Bonilla, Manuel G.

1975-01-01

Six faults associated with five large earthquakes produced surface displacements ranging from 1 to 3 m in the period 1906 through 1951. Four of the ruptures occurred in the western coastal plain and foothills, and two occurred in the Longitudinal Valley of eastern Taiwan. Maps are included showing the locations and dimensions of the displacements. The published geological literature probably would not lead one to infer the existence of a fault along most of the 1906 rupture, except for descriptions of the rupture itself. Over most of its length the 1935 rupture on the Chihhu fault is parallel to but more than 0.5 km from nearby faults shown on geologic maps published in 1969 and 1971; only about 1.5 km of its 15 km length coincides with a mapped fault. The coastal plain part of the Tuntzuchio fault which ruptured in 1935 is apparently not revealed by landforms, and only suggested by other data. Part of the 1946 Hsinhua faulting coincides with a fault identified in the subsurface by seismic work but surface indications of the fault are obscure. The 1951 Meilun faulting occurred along a conspicuous pre-1951 scarp and the 1951 Yuli faulting occurred near or in line with pre-1951 scarps. More than 40 faults which, according to the published literature, have had Pleistocene or later movement are shown on a small-scale map. Most of these faults are in the densely-populated western part of Taiwan. The map and text calls attention to faults that may be active and therefore may be significant in planning important structures. Equivocal evidence suggestive of fault creep was found on the Yuli fault and the Hsinhua fault. Fault creep was not found at several places examined along the 1906 fault trace. Tectonic uplift has occurred in Taiwan in the last 10,000 years and application of eustatic sea level curves to published radiocarbon dates shows that the minimum rate of uplift is considerably different in different parts of the island. Incomplete data indicate that the rate is high near Hualien, where an uplift of at least 0.6 m and probably more than 1 m occurred in the 1951 earthquake, and near and south of the 1946 faulting. Sudden uplifts can have serious consequences for installations near the shore. Investigation of this process, study of recently active faults, and continuing study of seismicity are necessary parts of a practical earthquake-hazard reduction program.

A microstructural study of fault rocks from the SAFOD: Implications for the deformation mechanisms and strength of the creeping segment of the San Andreas Fault

NASA Astrophysics Data System (ADS)

Hadizadeh, Jafar; Mittempergher, Silvia; Gratier, Jean-Pierre; Renard, Francois; Di Toro, Giulio; Richard, Julie; Babaie, Hassan A.

2012-09-01

The San Andreas Fault zone in central California accommodates tectonic strain by stable slip and microseismic activity. We study microstructural controls of strength and deformation in the fault using core samples provided by the San Andreas Fault Observatory at Depth (SAFOD) including gouge corresponding to presently active shearing intervals in the main borehole. The methods of study include high-resolution optical and electron microscopy, X-ray fluorescence mapping, X-ray powder diffraction, energy dispersive X-ray spectroscopy, white light interferometry, and image processing. The fault zone at the SAFOD site consists of a strongly deformed and foliated core zone that includes 2-3 m thick active shear zones, surrounded by less deformed rocks. Results suggest deformation and foliation of the core zone outside the active shear zones by alternating cataclasis and pressure solution mechanisms. The active shear zones, considered zones of large-scale shear localization, appear to be associated with an abundance of weak phases including smectite clays, serpentinite alteration products, and amorphous material. We suggest that deformation along the active shear zones is by a granular-type flow mechanism that involves frictional sliding of microlithons along phyllosilicate-rich Riedel shear surfaces as well as stress-driven diffusive mass transfer. The microstructural data may be interpreted to suggest that deformation in the active shear zones is strongly displacement-weakening. The fault creeps because the velocity strengthening weak gouge in the active shear zones is being sheared without strong restrengthening mechanisms such as cementation or fracture sealing. Possible mechanisms for the observed microseismicity in the creeping segment of the SAF include local high fluid pressure build-ups, hard asperity development by fracture-and-seal cycles, and stress build-up due to slip zone undulations.

Structural Analysis and Evolution of the Kashan (Qom-Zefreh) Fault, Central Iran

NASA Astrophysics Data System (ADS)

Safaei, H.; Taheri, A.; Vaziri-Moghaddam, H.

The main objectives of this research were to identify the geometry and structure of the Qom-Zefreh fault and to determine the extent of its effects on stratigraphy and facies changes. The identification of movement mechanism of major faults in basement, extent and time of their activities are important effects for evaluation of paleogeography of the Iran plateau. In the Orumieh-Dokhtar volcanic band, there are nearly parallel faults to the Zagros Zone. These faults were formed during closure of the Neothetys and collision of the Arabic plate with crust of Iran. The Qom-Zefreh fault is one of these faults, which is known as having four different trend faults. The result indicates that, this fault is not divided in four segments with different trends but the major trend is of Central section, which is the Kashan segment with AZ140 trend and other segments are just related faults. Thus the name of the Kashan fault is recommended for this fault. The mechanism of the Kashan fault is dextral transpression and other related faults in the region are in good correlation with fractures in a dextral transpression system. The stratigraphic studies conducted on the present formations show the effect of fault movements in Upper Cretaceous sedimentary basin. Lack of noticeable changes in Lower Cretaceous sediments and before that indicates that, the fault system activity has been started from the Upper Cretaceous. Thus, based upon these results, the effect of the Neothetys sea closure in this region could be considered at least from the Upper Cretaceous.

Trench logs, terrestrial lidar system imagery, and radiocarbon data from the kilometer-62 site on the Greenville Fault, southeastern Alameda County, California, 2014

USGS Publications Warehouse

Lienkaemper, James J.; DeLong, Stephen B.; Avdievitch, Nikita N.; Pickering, Alexandra J; Guilderson, Thomas P.

2015-01-01

In 2014, we investigated an abrupt 8.5-meter (m), right-laterally deflected stream channel located near the Greenville Fault in southeastern Alameda County, California (-121.56224° E, 37.53430° N) that we discovered using 0.5-m resolution, 2011 aerial lidar imagery flown along the active fault trace. Prior to trenching we surveyed the site using a terrestrial lidar system (TLS) to document the exact geomorphic expression of this deflected stream channel before excavating a trench adjacent to it. We trenched perpendicular to the fault hoping to document the prehistoric history of earthquake ruptures along the fault. However, the alluvial stratigraphy that we document in these trench logs shows conclusively that this trench did not expose any active fault trace. Using other local geomorphic evidence for the fault location, a straight fault scarp immediately north of this stream projects slightly upslope of the west end of our trench and may be the actual location of the active fault trace. Five radiocarbon samples establish age control for the alluvial sequence documented in the trench, which may in the future be useful in constraining the long-term slip rate of the Greenville Fault. The deflection had been caused by an abrupt nontectonic termination of unit u30, a relatively thick (0.15–0.35 m) silt that is more erosion resistant than the adjacent cohesionless sand and gravel. 

Ground-penetrating radar investigation of active faults along the Dead Sea Transform and implications for seismic hazards within the city of Aqaba, Jordan

NASA Astrophysics Data System (ADS)

Slater, Lee; Niemi, Tina M.

2003-06-01

Ground-penetrating radar (GPR) was used in an effort to locate a major active fault that traverses Aqaba City, Jordan. Measurements over an exposed (trenched) cross fault outside of the city identify a radar signature consisting of linear events and horizontal offset/flexured reflectors both showing a geometric correlation with two known faults at a control site. The asymmetric linear events are consistent with dipping planar reflectors matching the known direction of dip of the faults. However, other observations regarding this radar signature render the mechanism generating these events more complex and uncertain. GPR measurements in Aqaba City were limited to vacant lots. Seven GPR profiles were conducted approximately perpendicular to the assumed strike of the fault zone, based on regional geological evidence. A radar response very similar to that obtained over the cross fault was observed on five of the profiles in Aqaba City, although the response is weaker than that obtained at the control site. The positions of the identified responses form a near straight line with a strike of 45°. Although subsurface verification of the fault by trenching within the city is needed, the geophysical evidence for fault zone location is strong. The location of the interpreted fault zone relative to emergency services, military bases, commercial properties, and residential areas is defined to within a few meters. This study has significant implications for seismic hazard analysis in this tectonically active and heavily populated region.

Neotectonics of interior Alaska and the late Quaternary slip rate along the Denali fault system

USGS Publications Warehouse

Haeussler, Peter J.; Matmon, Ari; Schwartz, David P.; Seitz, Gordon G.

2017-01-01

The neotectonics of southern Alaska (USA) are characterized by a several hundred kilometers–wide zone of dextral transpressional that spans the Alaska Range. The Denali fault system is the largest active strike-slip fault system in interior Alaska, and it produced a Mw 7.9 earthquake in 2002. To evaluate the late Quaternary slip rate on the Denali fault system, we collected samples for cosmogenic surface exposure dating from surfaces offset by the fault system. This study includes data from 107 samples at 19 sites, including 7 sites we previously reported, as well as an estimated slip rate at another site. We utilize the interpreted surface ages to provide estimated slip rates. These new slip rate data confirm that the highest late Quaternary slip rate is ∼13 mm/yr on the central Denali fault near its intersection with the eastern Denali and the Totschunda faults, with decreasing slip rate both to the east and west. The slip rate decreases westward along the central and western parts of the Denali fault system to 5 mm/yr over a length of ∼575 km. An additional site on the eastern Denali fault near Kluane Lake, Yukon, implies a slip rate of ∼2 mm/yr, based on geological considerations. The Totschunda fault has a maximum slip rate of ∼9 mm/yr. The Denali fault system is transpressional and there are active thrust faults on both the north and south sides of it. We explore four geometric models for southern Alaska tectonics to explain the slip rates along the Denali fault system and the active fault geometries: rotation, indentation, extrusion, and a combination of the three. We conclude that all three end-member models have strengths and shortcomings, and a combination of rotation, indentation, and extrusion best explains the slip rate observations.

Evolution of triangular topographic facets along active normal faults

NASA Astrophysics Data System (ADS)

Balogun, A.; Dawers, N. H.; Gasparini, N. M.; Giachetta, E.

2011-12-01

Triangular shaped facets, which are generally formed by the erosion of fault - bounded mountain ranges, are arguably one of the most prominent geomorphic features on active normal fault scarps. Some previous studies of triangular facet development have suggested that facet size and slope exhibit a strong linear dependency on fault slip rate, thus linking their growth directly to the kinematics of fault initiation and linkage. Other studies, however, generally conclude that there is no variation in triangular facet geometry (height and slope) with fault slip rate. The landscape of the northeastern Basin and Range Province of the western United States provides an opportunity for addressing this problem. This is due to the presence of well developed triangular facets along active normal faults, as well as spatial variations in fault scale and slip rate. In addition, the Holocene climatic record for this region suggests a dominant tectonic regime, as the faulted landscape shows little evidence of precipitation gradients associated with tectonic uplift. Using GIS-based analyses of USGS 30 m digital elevation data (DEMs) for east - central Idaho and southwestern Montana, we analyze triangular facet geometries along fault systems of varying number of constituent segments. This approach allows us to link these geometries with established patterns of along - strike slip rate variation. For this study, we consider major watersheds to include only catchments with upstream and downstream boundaries extending from the drainage divide to the mapped fault trace, respectively. In order to maintain consistency in the selection criteria for the analyzed triangular facets, only facets bounded on opposite sides by major watersheds were considered. Our preliminary observations reflect a general along - strike increase in the surface area, average slope, and relief of triangular facets from the tips of the fault towards the center. We attribute anomalies in the along - strike geometric measurements of the triangular facets to represent possible locations of fault segment linkage associated with normal fault evolution.

How does the 2010 El Mayor - Cucapah Earthquake Rupture Connect to the Southern California Plate Boundary Fault System

NASA Astrophysics Data System (ADS)

Donnellan, A.; Ben-Zion, Y.; Arrowsmith, R.

2016-12-01

The Pacific - North American plate boundary in southern California is marked by several major strike slip faults. The 2010 M7.2 El Mayor - Cucapah earthquake ruptured 120 km of upper crust in Baja California to the US-Mexico border. The earthquake triggered slip along an extensive network of faults in the Salton Trough from the Mexican border to the southern end of the San Andreas fault. Earthquakes >M5 were triggered in the gap between the Laguna Salada and Elsinore faults at Ocotillo and on the Coyote Creek segment of the San Jacinto fault 20 km northwest of Borrego Springs. UAVSAR observations, collected since October of 2009, measure slip associated with the M5.7 Ocotillo aftershock with deformation continuing into 2014. The Elsinore fault has been remarkably quiet, however, with only M5.0 and M5.2 earthquakes occurring on the Coyote Mountains segment of the fault in 1940 and 1968 respectively. In contrast, the Imperial Valley has been quite active historically with numerous moderate events occurring since 1935. Moderate event activity is increasing along the San Jacinto fault zone (SJFZ), especially the trifurcation area, where 6 of 12 historic earthquakes in this 20 km long fault zone have occurred since 2000. However, no recent deformation has been detected using UAVSAR measurements in this area, including the recent M5.2 June 2016 Borrego earthquake. Does the El Mayor - Cucapah rupture connect to and transfer stress primarily to a single southern California fault or several? What is its role relative to the background plate motion? UAVSAR observations indicate that the southward extension of the Elsinore fault has recently experienced the most localized deformation. Seismicity suggests that the San Jacinto fault is more active than neighboring major faults, and geologic evidence suggests that the Southern San Andreas fault has been the major plate boundary fault in southern California. Topographic data with 3-4 cm resolution using structure from motion from a small UAV on the southern San Andreas fault and the San Jacinto fault south of Anza, decimeter level B4 lidar data, GPS, and UAVSAR observations flown as recently as June 2016 will serve as baseline data for future large earthquakes in the region. Models that combine the different data sets are required to better understand the interconnections of the faults.

Space-time evolution of a growth fold (Betic Cordillera, Spain). Evidences from 3D geometrical modelling

NASA Astrophysics Data System (ADS)

Martin-Rojas, Ivan; Alfaro, Pedro; Estévez, Antonio

2014-05-01

We present a study that encompasses several software tools (iGIS©, ArcGIS©, Autocad©, etc.) and data (geological mapping, high resolution digital topographic data, high resolution aerial photographs, etc.) to create a detailed 3D geometric model of an active fault propagation growth fold. This 3D model clearly shows structural features of the analysed fold, as well as growth relationships and sedimentary patterns. The results obtained permit us to discuss the kinematics and structural evolution of the fold and the fault in time and space. The study fault propagation fold is the Crevillente syncline. This fold represents the northern limit of the Bajo Segura Basin, an intermontane basin in the Eastern Betic Cordillera (SE Spain) developed from upper Miocene on. 3D features of the Crevillente syncline, including growth pattern, indicate that limb rotation and, consequently, fault activity was higher during Messinian than during Tortonian; consequently, fault activity was also higher. From Pliocene on our data point that limb rotation and fault activity steadies or probably decreases. This in time evolution of the Crevillente syncline is not the same all along the structure; actually the 3D geometric model indicates that observed lateral heterogeneity is related to along strike variation of fault displacement.

Active faulting at Delphi, Greece: Seismotectonic remarks and a hypothesis for the geologic environment of a myth

NASA Astrophysics Data System (ADS)

Piccardi, Luigi

2000-07-01

Historical data are fundamental to the understanding of the seismic history of an area. At the same time, knowledge of the active tectonic processes allows us to understand how earthquakes have been perceived by past cultures. Delphi is one of the principal archaeological sites of Greece, the main oracle of Apollo. It was by far the most venerated oracle of the Greek ancient world. According to tradition, the mantic proprieties of the oracle were obtained from an open chasm in the earth. Delphi is directly above one of the main antithetic active faults of the Gulf of Corinth Rift, which bounds Mount Parnassus to the south. The geometry of the fault and slip-parallel lineations on the main fault plane indicate normal movement, with minor right-lateral slip component. Combining tectonic data, archaeological evidence, historical sources, and a reexamination of myths, it appears that the Helice earthquake of 373 B.C. ruptured not only the master fault of the Gulf of Corinth Rift at Helice, but also the antithetic fault at Delphi, similarly to the Corinth earthquake of 1981. Moreover, the presence of an active fault directly below the temples of the oldest sanctuary suggests that the mythological oracular chasm might well have been an ancient tectonic surface rupture.

Subsurface structure identification of active fault based on magnetic anomaly data (Case study: Toru fault in Sumatera fault system)

NASA Astrophysics Data System (ADS)

Simanjuntak, Andrean V. H.; Husni, Muhammad; Syirojudin, Muhammad

2017-07-01

Toru segment, which is one of the active faults and located in the North of Sumatra, broke in 1984 ago on Pahae Jahe's earthquake with a magnitude 6.4 at the northern part of the fault which has a length of 23 km, and also broke again at the same place in 2008. The event of recurrence is very fast, which only 25 years old have repeatedly returned. However, in the elastic rebound theory, it probably happen with a fracture 50 cm and an average of the shear velocity 20 mm/year. The average focus of the earthquake sourced at a depth of 10 km and 23 km along its fracture zones, which can generate enough shaking 7 MMI and could breaking down buildings and create landslides on the cliff. Due to its seismic activity, this study was made to identify the effectiveness of this fault with geophysical methods. Geophysical methods such as gravity, geomagnetic and seismology are powerful tools for detecting subsurface structures of local, regional as well as of global scales. This study used to geophysical methods to discuss about total intensity of the geomagnetic anomaly data, resulted in the distribution of susceptibility values corresponding to the fault movement. The geomagnetic anomalies data was obtained from Geomag, such as total intensity measured by satellite. Data acquisition have been corrected for diurnal variations and reduced by IGRF. The study of earthquake records can be used for differentiating the active and non active fault elements. Modeling has been done using several methods, such as pseudo-gravity, reduce to pole, and upward or downward continuation, which is used to filter the geomagnetic anomaly data because the data has not fully representative of the fault structure. The results indicate that rock layers of 0 - 100 km depth encountered the process of intrusion and are dominated by sedimentary rocks that are paramagnetic, and that the ones of 100 - 150 km depth experienced the activity of subducting slab consisting of basalt and granite which are ferromagnetic and semi-ferromagnetic. This concluded that all the occurences correspond to the high seismicity and seismotectonic condition of Toru fault.

Structural controls on a geothermal system in the Tarutung Basin, north central Sumatra

NASA Astrophysics Data System (ADS)

Nukman, Mochamad; Moeck, Inga

2013-09-01

The Sumatra Fault System provides a unique geologic setting to evaluate the influence of structural controls on geothermal activity. Whereas most of the geothermal systems in Indonesia are controlled by volcanic activity, geothermal systems at the Sumatra Fault System might be controlled by faults and fractures. Exploration strategies for these geothermal systems need to be verified because the typical pattern of heat source and alteration clays are missing so that conventional exploration with magnetotelluric surveys might not provide sufficient data to delineate favorable settings for drilling. We present field geological, structural and geomorphological evidence combined with mapping of geothermal manifestations to allow constraints between fault dynamics and geothermal activity in the Tarutung Basin in north central Sumatra. Our results indicate that the fault pattern in the Tarutung Basin is generated by a compressional stress direction acting at a high angle to the right-lateral Sumatra Fault System. NW-SE striking normal faults possibly related to negative flower structures and NNW-SSE to NNE-SSW oriented dilative Riedel shears are preferential fluid pathways whereas ENE-WSW striking faults act as barriers in this system. The dominant of geothermal manifestations at the eastern part of the basin indicates local extension due to clockwise block rotation in the Sumatra Fault System. Our results support the effort to integrate detailed field geological surveys to refined exploration strategies even in tropical areas where outcrops are limited.

Microstructural characterization of high-manganese austenitic steels with different stacking fault energies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sato, Shigeo, E-mail: s.sato@imr.tohoku.ac.jp; Kwon, Eui-Pyo; Imafuku, Muneyuki

Microstructures of tensile-deformed high-manganese austenitic steels exhibiting twinning-induced plasticity were analyzed by electron backscatter diffraction pattern observation and X-ray diffraction measurement to examine the influence of differences in their stacking fault energies on twinning activity during deformation. The steel specimen with the low stacking fault energy of 15 mJ/m{sup 2} had a microstructure with a high population of mechanical twins than the steel specimen with the high stacking fault energy (25 mJ/m{sup 2}). The <111> and <100> fibers developed along the tensile axis, and mechanical twinning occurred preferentially in the <111> fiber. The Schmid factors for slip and twinning deformationsmore » can explain the origin of higher twinning activity in the <111> fiber. However, the high stacking fault energy suppresses the twinning activity even in the <111> fiber. A line profile analysis based on the X-ray diffraction data revealed the relationship between the characteristics of the deformed microstructures and the stacking fault energies of the steel specimens. Although the variation in dislocation density with the tensile deformation is not affected by the stacking fault energies, the effect of the stacking fault energies on the crystallite size refinement becomes significant with a decrease in the stacking fault energies. Moreover, the stacking fault probability, which was estimated from a peak-shift analysis of the 111 and 200 diffractions, was high for the specimen with low stacking fault energy. Regardless of the difference in the stacking fault energies of the steel specimens, the refined crystallite size has a certain correlation with the stacking fault probability, indicating that whether the deformation-induced crystallite-size refinement occurs depends directly on the stacking fault probability rather than on the stacking fault energies in the present steel specimens. - Highlights: {yields} We studied effects of stacking fault energies on deformed microstructures of steels. {yields} Correlations between texture and occurrence of mechanical twinning are discussed. {yields} Evolutions of dislocations and crystallite are analyzed by line profile analysis.« less