Science.gov

Sample records for muerte del instituto

  1. Se evitaron casi 800 000 muertes por descenso del tabaquismo

    Cancer.gov

    Programas y estrategias de control del tabaco del siglo XX fueron responsables de la prevención de más de 795 000 muertes por cáncer de pulmón en Estados Unidos de 1975 al 2000. Si todo el tabaquismo en este país hubiera cesado después de la publicación d

  2. [History of Instituto Nacional de Salud Ocupacional del Peru].

    PubMed

    Cossio-Brazzan, Juan M

    2012-06-01

    In Peru, the industry's development has made economic improvements but at the same time, it has had a major impact on the health of the workers; for that reason, it was necessary to generate control mechanisms. So, in 1940 it was created the Departmento de Higiene Industrial, which in 1956 was changed to Instituto de Salud Ocupacional, but it was deactivated in 1994. However, in 2001 it reappeared into the Ministerio de Salud organizational structure with the name of Instituto de Salud Ocupacional "Alberto Hurtado Abadía". Actually, it is the Centro Nacional de Salud Ocupacional y Protección del Ambiente para la Salud (CENSOPAS), organ of the Instituto Nacional de Salud which continues working in synergy with other institutions and sectors, making research to protect the health of exposed persons (workers and community) to contamination and risks associated with economic activities. PMID:22858781

  3. [History of Instituto Nacional de Salud Ocupacional del Peru].

    PubMed

    Cossio-Brazzan, Juan M

    2012-06-01

    In Peru, the industry's development has made economic improvements but at the same time, it has had a major impact on the health of the workers; for that reason, it was necessary to generate control mechanisms. So, in 1940 it was created the Departmento de Higiene Industrial, which in 1956 was changed to Instituto de Salud Ocupacional, but it was deactivated in 1994. However, in 2001 it reappeared into the Ministerio de Salud organizational structure with the name of Instituto de Salud Ocupacional "Alberto Hurtado Abadía". Actually, it is the Centro Nacional de Salud Ocupacional y Protección del Ambiente para la Salud (CENSOPAS), organ of the Instituto Nacional de Salud which continues working in synergy with other institutions and sectors, making research to protect the health of exposed persons (workers and community) to contamination and risks associated with economic activities.

  4. Estudio de los Institutos Nacionales de la Salud indica que quienes toman café tienen un riesgo meno

    Cancer.gov

    Los adultos mayores que tomaron café, con o sin cafeína, tuvieron un riesgo menor de muerte en general que quienes no tomaron café, según un estudio llevado a cabo por investigadores del Instituto Nacional del Cáncer (NCI), parte de los Institutos Naciona

  5. [Causes of maternal mortality in the Instituto Mexicano del Seguro Social, period 2009-2012].

    PubMed

    Ruíz-Rosas, Roberto Aguli; Cruz-Cruz, Polita Rocío

    2014-01-01

    Introducción: la razón de muerte materna (RMM) ha disminuido lentamente, no obstante que la OMS se propuso reducirla en un 75 % en el período de 1990 a 2015. Por esto es necesario continuar con el análisis de las causas para reforzar e innovar líneas de acción y así disminuir las muertes maternas en nuestro país. Métodos: estudio retrospectivo en el que se incluyeron casos de muerte materna que ocurrieron de 2009 a 2012, por causa directa e indirecta. La información se obtuvo del expediente de muerte materna, el cual es un documento oficial del IMSS. La definición de muerte materna utilizada fue la emitida por la OMS. Las muertes indirectas se agruparon según la décima revisión de la Clasificación Internacional de Enfermedades (CIE-10). Se utilizó estadística descriptiva. Resultados: la RMM en el IMSS ha disminuido en forma lenta pero constante, pues en el 2012 se obtuvo la RMM más baja en la institución (26.4). Sin embargo, la preeclampsia severa-eclampsia y la hemorragia obstétrica ocuparon el primero y segundo lugar. Como causa indirecta, las enfermedades del sistema cardiovascular, y las neoplasias malignas ocuparon los primeros lugares sin subestimar las cifras de las patologías respiratorias, digestivas y endocrinas. Conclusiones: es necesario proseguir con los esfuerzos para disminuir la RMM en todos los niveles de atención médica. Es prioritario continuar con la educación y consejería preconcepcional a mujeres en edad fértil y fortalecer las acciones en la planificación familiar.

  6. [Strengths and future of the Revista Médica del Instituto Mexicano del Seguro Social].

    PubMed

    Fajardo-Dolci, Germán

    2014-01-01

    The journals of medicine arose as a communication tool more than 200 years ago. At the beginning, their nature was local; later, their aim was to spread medical information along the nation; and, finally, they sought to reach the world distribution. The Revista Médica del Instituto Mexicano del Seguro Social was published for the first time 52 years ago, and it has walked its way from local to international distribution. This journal has 23 000 subscribers, it is included in Medline and it reached a 0.112 SCImago Journal Rank in 2012. Its website receives around 200 000 visits monthly and 45 % are foreign visits. In the future, the peer review system is going to be strengthened, and the journal is going to offer audio, video, and applications to reinforce interactive participation between authors, readers in order to reach modernity and draw young new attention.

  7. [Seventy years of medicine in the Instituto Mexicano del Seguro Social].

    PubMed

    Fajardo-Ortiz, Guillermo

    2014-01-01

    The purpose of these lines is to remember and refer some of the historical landmarks in the evolution of the medical services of the Instituto Mexicano del Seguro Social (IMSS, according to its initials in Spanish) since it was founded, in 1943. We also want to bring to the reader's attention that the dimensions and impacts on health that IMSS has achieved, throughout its history, have strengthened the citizenship, as well as social sustainability. Also, those impacts have determined the creation and the reinforcement of human capital in México. Throughout this concise balance, all the controversy surrounding the foundation of the Institute is being recalled (the protest in the Mexico City Zócalo, or the attack to an hospital in San Ángel -a neighborhood located in the Southwest of Mexico City-), as well as the way the IMSS incorporated several words into the vocabulary of Mexicans. We also remember the previous antecedent of the Revista Médica del Instituto Mexicano del Seguro Social, as well as the Revista de Enfermería, and the emblematic Archives of Medical Research. The IMSS has 70 years of achievements, seven decades covered.

  8. [Diabetes mortality in the Instituto Mexicano del Seguro Social, 1990-2005].

    PubMed

    Fernández-Cantón, Sonia

    2010-01-01

    Diabetes is major contributor to the mortality in the Mexican population and particularly in the population insured by social security institutions like The Instituto Mexicano del Seguro Social (IMSS). Mortality rates have duplicated from 1990 to 2005 period and in some regions the increment has been even higher and faster. Men not insured by IMSS present the lowest mortality rates. Mortality by chronic diseases is no longer a problem of affluent regions since Chiapas, Oaxaca and Guerrero, the poorest states in the country, have higher rates of increment than the northern and more developed regions. The different interventions employed by the health institutions should impact mortality rates in both the magnitude and velocity of increment especially in those regions where growth of mortality have been higher.

  9. [Mortality from the HIV/AIDS in the Instituto Mexicano del Seguro Social].

    PubMed

    Vázquez-Martínez, José Luis; Mercadillo-Pérez, María Guadalupe; Celis-Quintal, Juan Germán

    2011-01-01

    Mortality is an indicator that allow us to evaluate HIV infection control programs. From the middle of the last decade, mortality presents a tendency to decrease in the population covered by the Instituto Mexicano del Seguro Social). In relation to gender and age group the most affected are men between 25 to 44 years of age with mortality rates ranging from 30 to 12 by 100,000 men (1995 to 2009 respectively). In 2009, at least half of the Delegaciones (administrative units by State) present larger mortality rates than the institutional average, particularly Campeche with 14.9 by 100,000 men. It is clear that introduction of control measures against the disease from infected people represents a modification in the course of the illness in the population covered by IMSS.

  10. [Historical notes about scientific research in the Instituto Mexicano del Seguro Social.

    PubMed

    Zárate, Arturo; Basurto-Acevedo, Lourdes

    2013-01-01

    Medical research in the Instituto Mexicano del Seguro Social has been considered one of the most important in this country for quality and quantity. Thanks to the work and leadership of Benito Coquet, who initiated the building of the National Medical Center in 1961, and the work of two pillars of research, Luis Castelazo and Bernardo Sepúlveda, the Institute successfully improved scientific research. In the years that followed, the Institute fostered the professionalization of research, the creation of research units in different areas of science, the incorporation of consolidated groups of researchers, the relationship with other institutions, the incorporation to the Sistema Nacional de Investigadores, the editing of a journal to expose outside the work done within the Institute, and the formation of a trust to raise funds for financing. Thanks to all that, institutional research strengthened in all lines, and it was placed first, at certain times, at the national level. PMID:24290017

  11. [Historical notes about scientific research in the Instituto Mexicano del Seguro Social.

    PubMed

    Zárate, Arturo; Basurto-Acevedo, Lourdes

    2013-01-01

    Medical research in the Instituto Mexicano del Seguro Social has been considered one of the most important in this country for quality and quantity. Thanks to the work and leadership of Benito Coquet, who initiated the building of the National Medical Center in 1961, and the work of two pillars of research, Luis Castelazo and Bernardo Sepúlveda, the Institute successfully improved scientific research. In the years that followed, the Institute fostered the professionalization of research, the creation of research units in different areas of science, the incorporation of consolidated groups of researchers, the relationship with other institutions, the incorporation to the Sistema Nacional de Investigadores, the editing of a journal to expose outside the work done within the Institute, and the formation of a trust to raise funds for financing. Thanks to all that, institutional research strengthened in all lines, and it was placed first, at certain times, at the national level.

  12. [Perspective on type 2 diabetes mellitus in the Instituto Mexicano del Seguro Social].

    PubMed

    Gil-Velázquez, Luisa Estela; Sil-Acosta, María Juana; Aguilar-Sánchez, Leticia; Echevarria-Zuno, Santiago; Michaus-Romero, Francisco; Torres-Arreola, Laura del Pilar

    2013-01-01

    The Instituto Mexicano del Seguro Social--always sensitive to the needs of health of the beneficiary population and to the demographic and epidemiological changes of the society--has developed and implemented DiabetlMSS, a program of attention to the diabetic patient. DiabetlMSS organizes care processes based on the needs and values of the patients, through simultaneous activities of individual consultation and group meetings granted by the multidisciplinary health team. These actions and activities are focused to affect patients' lifestyles positively. Through a plan of nutrition, physical activity, self-care and monitoring, this program increases the interaction between patients, by having an exchange of successful experiences about diabetes control. DiabetlMSS was created with the purpose that the patients achieve the metabolic control and identify complications early on, with the perspective of timely intervention that is reflected in the decrease of the catastrophic effects that causes the disease, both for patient's life expectancy and the quality of care provided by the Institute.

  13. [Current status of alternative therapies renal function at the Instituto Mexicano del Seguro Social].

    PubMed

    Méndez-Durán, Antonio; Ignorosa-Luna, Manuel Humberto; Pérez-Aguilar, Gilberto; Rivera-Rodríguez, Francisco Jesús; González-Izquierdo, José Jesús; Dávila-Torres, Javier

    2016-01-01

    Introducción: el IMSS realiza de manera sistemática la actualización de datos de los pacientes en terapias sustitutivas de la función renal (TSFR) mediante un registro electrónico denominado: Censo de administración de pacientes con Insuficiencia Renal Crónica (CIRC), cuyo objetivo es conocer la prevalencia de pacientes con insuficiencia renal crónica y el comportamiento de las TSFR en el IMSS. Métodos: estudio retrospectivo, incluye 212 hospitales de segundo nivel con programas de diálisis, pacientes pediátricos y adultos. Datos obtenidos del CIRC de enero a diciembre de 2014, cédulas numeral y nominal de diálisis peritoneal (DP) y hemodiálisis (HD). Se identifica prevalencia de pacientes y terapias por delegación, distribución por género y edad, causa de la enfermedad renal, la morbilidad y mortalidad. Resultados: 55 101 pacientes, de los cuales fueron 29 924 masculinos (54 %) y 25 177 femeninos (46 %); edad promedio 62.1 años (rng: 4 a 90); pensionados 20 387 (36.9 %). Las causas de la insuficiencia renal fueron: diabetes 29 054 (52.7 %), hipertensión arterial 18 975 (34.4%), glomerulopatías crónicas 3951 (7.2 %), riñones poliquísticos 1142 (2.1 %), congénitos 875 (1.6 %), y otras 1104 (2 %). La HD se otorgó en 41 % de los pacientes y la DP al 59 % restante; el costo anual fue de 5 608 290 622 pesos. Conclusiones: la prevalencia incrementada de diabetes mellitus e hipertensión arterial repercuten en el inicio de una TSFR, las cuales muestran un panorama financiero catastrófico para el Instituto.

  14. Control del cáncer y salud mundial: noticia del Instituto Nacional del Cáncer (NCI)

    Cancer.gov

    En combinación con una reunión de alto nivel de las Naciones Unidas sobre enfermedades no transmisibles en países en vías de desarrollo, el doctor Harold Varmus, director del NCI, y el doctor Ted L. Trimble, del NCI, han publicado un comentario en Science

  15. Radiation treatment of early vocal cord carcinoma. Eighteen years experience at "Instituto de Oncologia y Radioterapia de Mar del Plata".

    PubMed

    Castro Vita, H

    1990-01-01

    A detailed retrospective analysis of 260 patients with T 1 NO MO vocal cord carcinoma treated at "Instituto de Oncologia y Radioterapia de Mar del Plata" from 1967 to 1985 was performed. The majority of the patients were in the age range of 50 to 79 years, and 79% were males. The overall observed three year tumor free survival was 85.3%. When survival rate was adjusted for intercurrent disease and second primary tumor death, the 3 year tumor free survival was 92%. Sixty two percent of the patients (17/27) undergoing surgical salvage for recurrence, were controlled. Second primary tumors were seen in 18 patients (6.9%). It is emphasized the importance of close follow up to diagnose as early as possible both the vocal cord recurrence and the second primary tumors.

  16. [Breast self-examination in users of the Instituto Mexicano del Seguro Social from Teapa, Tabasco, Mexico].

    PubMed

    Córdova-Cadena, Samuel; González-Pozos, Patricia Vanessa; Zavala-González, Marco Antonio

    2015-01-01

    Objetivo: determinar la proporción de mujeres de 40 años o más que se realizan correctamente autoexploración mamaria en la Unidad Médica Familiar 18 del Instituto Mexicano del Seguro Social, en Teapa, Tabasco, México, en el año 2011. Métodos: estudio transversal, de un universo de 1457 mujeres del que se obtuvo una muestra probabilística de 127, seleccionadas sistematizadamente. Se incluyeron variables sociodemográficas, antecedentes heredofamiliares de cáncer de mama y la evaluación de la técnica de autoexploración. La información fue obtenida de expedientes clínicos y listas de cotejo. Se obtuvo estadística descriptiva. Resultados: La edad media fue de 52.7 ± 9.3 con un intervalo de confianza de 40-80 años. La escolaridad predominante fue la primaria con 35.4 %. Hubo antecedente heredofamiliar de tumor maligno de las mamas en 11 %. La madre fue el familiar más frecuente con este antecedente (42.9 %). Hubo una correcta autoexploración mamaria en 0.8 %. Conclusiones: la proporción de mujeres que realizan correctamente la autoexploración mamaria es alarmantemente baja. No se encontraron factores asociados. Se requieren intervenciones educativas para corregir el problema.

  17. El Instituto Nacional del Cáncer de EE. UU. y Perú firman una Declaración de Intención

    Cancer.gov

    El Instituto Nacional del Cáncer y la República del Perú firmaron una declaración de intención para compartir el interés en fomentar la investigación biomédica de oncología, basándose en la colaboración mutua de ambas entidades, así como el objetivo común

  18. [Registry of myocardial infarction in a tertiary hospital of the Instituto Mexicano del Seguro Social].

    PubMed

    González-Pliego, José Angel; Gudiño-Amezcua, Diego Armando; Celis, Alfredo; Gutiérrez-Díaz, Gonzalo Israel

    2014-01-01

    Introducción: dado que el pronóstico de infarto del miocardio con elevación del segmento ST (IMCEST) depende de su manejo inmediato y de las medidas de prevención secundaria, el no seguir las recomendaciones actuales impide mejorar las expectativas de la población afectada por este padecimiento. El objetivo es describir el perfil clínico-epidemiológico y el proceso de atención del IMCEST en un hospital de tercer nivel. Métodos: se analiza la información clínica, la estratificación de riesgo, la terapia de revascularización y los hábitos de prescripción al egreso de los casos con IMCEST atendidos en un año. Resultados: se incluyeron 246 pacientes con edad promedio de 61 años; el 76 % fueron varones. La mayoría (37.3 %) de IMCEST ocurrió entre los 60 y los 69 años. El sedentarismo fue el factor de riesgo predominante. El 81.7 % de los casos tuvo score TIMI de riesgo bajo. El 35 % tuvo isquemia/viabilidad y en todos los cateterizados se demostraron obstrucciones coronarias. El 76 % se revascularizó con stent, principalmente farmacológico (77.5 %). Al egreso más del 90 % de los casos recibió estatina y antiplaquetarios, mientras otras drogas se prescribieron al 64-82 % de los casos. Conclusiones: el IMCEST predomina en hombres sedentarios de la séptima década. Estratificar el riesgo, buscar isquemia/viabilidad residual y revascularizar con stent farmacológico son prácticas comunes; el cumplimiento de recomendaciones basadas en la evidencia es mejor que en el pasado, pero todavía no es óptimo.

  19. [Guideline for the assessment of clinical research proposals. Comisión Nacional de Investigación Científica del Instituto Mexicano del Seguro Social].

    PubMed

    Mejía-Aranguré, Juan Manuel; Grijalva-Otero, Israel; Majluf-Cruz, Abraham; Cruz-López, Miguel; Núñez-Enríquez, Juan Carlos; Salamanca-Gómez, Fabio Abdiel

    2013-01-01

    Antecedentes: la investigación médica es una herramienta fundamental para lograr el avance de la ciencia al mejorar las acciones encaminadas a proteger, promover y restaurar la salud del individuo y de la sociedad en general. Las tres características imprescindibles para que un protocolo de investigación sea autorizado son: relevancia científica, calidad técnica y el cumplimiento de los aspectos éticos. Material y métodos: estudio retrospectivo efectuado con base en la búsqueda específica en Pubmed, Medline, Ovid y Google Scholar con los términos: peer review, research proposals, review and protocols and reviewers. Debido a que no se identificó ningún artículo que refiriera específicamente los criterios para evaluar protocolos de investigación clínica, se hizo un consenso entre los vocales de la Comisión Nacional de Investigación Científica del Instituto Mexicano del Seguro Social, que está integrada por investigadores titulares de la institución, todos pertenecientes al Sistema Nacional de Investigadores. Se discutieron los criterios que debieran componer una revisión adecuada y cuáles debieran ser los rubros que deben incluirse en el análisis. Resultados: se integraron los criterios específicos que le permitirán al revisor de un protocolo de investigación realizar una crítica con bases metodológicas aceptadas por un consenso de investigadores. Conclusiones: un revisor debe ser considerado como un promotor del avance del conocimiento científico que, mediante sus comentarios y su dictamen, permite que los investigadores incrementen la calidad de sus protocolos de investigación.

  20. [The cord blood bank at the Instituto Mexicano del Seguro Social].

    PubMed

    Peñaflor-Juárez, Karina; Guillén-Chan, Sonia Marilyn; Romero-Juárez, Yanín; Luna-Bautista, Fernando; Franco-Gutiérrez, Elizabeth; Arellano-Ocampo, Jesús Salvador; Ibáñez-Sánchez, Rocío; de Lourdes Domínguez-Contreras, María; Guerra-Márquez, Angel

    2015-01-01

    Introducción: las células troncales hematopoyéticas se han empleado por más de 50 años en el tratamiento de diversas enfermedades. La sangre de cordón umbilical es una fuente viable de células troncales hematopoyéticas con fines de trasplante. El objetivo es informar la aportación clínica del banco de células de cordón umbilical (BCCU) en el tratamiento de diversas enfermedades.Métodos: desde 2005 a la fecha se analizó el número de unidades de sangre de cordón umbilical (SCU) y su empleo para el trasplante en diversas enfermedades. Se seleccionaron donadoras embarazadas voluntarias en trabajo de parto de quienes se recolectó SCU, la cual fue sometida a su procesamiento, criopreservación y validación, así como a estudios de compatibilidad previo a su uso para trasplante.Resultados: se evaluaron 10 099 candidatas a donación, de quienes se recolectaron 2481 unidades de SCU, de estas se procesaron y criopreservaron 893 unidades para trasplante. En 65 % de los casos hubo histocompatibilidad entre las células de cordón y el receptor. Se trasplantaron 87 pacientes (67 % neoplasias hematológicas), que recibieron 140 unidades SCU en 102 trasplantes.Conclusiones: nuestro Banco de CCU ha logrado desarrollar una línea celular (troncales hematopoyéticas) con estándares de calidad internacionales, y ha beneficiado a pacientes con necesidad de un trasplante, en especial los padecimientos oncohematológicos.

  1. Instituto de Astrofisica de Canarias

    NASA Astrophysics Data System (ADS)

    Murdin, P.

    2000-11-01

    The Instituto de Astrofisica de Canarias (IAC) and its Observatories—the OBSERVATORIO DEL TEIDE on Tenerife and the OBSERVATORIO DEL ROQUE DE LOS MUCHACHOS on La Palma—are a Spanish research center open, from 1979, to the international scientific community through its Agreements on Cooperation in Astrophysics. The IAC Observatories in fact form the European Northern Observatory (ENO), in which in...

  2. [Pertussis in Mexico, an epidemiological overview. A study of 19 years at the Instituto Mexicano del Seguro Social].

    PubMed

    Pérez-Pérez, Gabriela Fidela; Rojas-Mendoza, Teresita; Cabrera-Gaytán, David Alejandro; Grajales-Muñiz, Concepción

    2015-01-01

    Introducción: La infección por Bordetella pertussis ha sido un problema de salud pública en varios países desarrollados y en vías de desarrollo. El objetivo de este estudio fue describir el panorama epidemiológico de los casos de síndrome coqueluchoide y tos ferina del subsistema especial de vigilancia epidemiológica de 1992 a 2011en una población con seguridad social. Métodos: Se obtuvieron los casos del subsistema especial de vigilancia epidemiológica de tos ferina de 1992 a 2011. Se hizo análisis univariado de tasas, razones y proporciones. Se determinó prueba de Wilson para proporciones a un valor alfa del 0.05, t de Student para diferencia de medias. Resultados: Se aprecian ciclos epidémicos, cada tres a cinco años, la incidencia basal promedio, sin contar los años epidémicos, se considera de 0.1 casos confirmados por cada 100 000 derechohabientes adscritos a medicina familiar, la mayor incidencia se registró en 1997 y 2009. Los más afectados han sido los menores de 1 año de edad y en brotes, la enfermedad se presentó en edades mayores. Conclusión: Durante el periodo se observan ciclos epidémicos intermedios de 5 y 3 años, la presentación de la edad es consistente en otros países.

  3. Cost-effectiveness analysis for joint pain treatment in patients with osteoarthritis treated at the Instituto Mexicano del Seguro Social (IMSS): Comparison of nonsteroidal anti-inflammatory drugs (NSAIDs) vs. cyclooxygenase-2 selective inhibitors

    PubMed Central

    Contreras-Hernández, Iris; Mould-Quevedo, Joaquín F; Torres-González, Rubén; Goycochea-Robles, María Victoria; Pacheco-Domínguez, Reyna Lizette; Sánchez-García, Sergio; Mejía-Aranguré, Juan Manuel; Garduño-Espinosa, Juan

    2008-01-01

    Background Osteoarthritis (OA) is one of the main causes of disability worldwide, especially in persons >55 years of age. Currently, controversy remains about the best therapeutic alternative for this disease when evaluated from a cost-effectiveness viewpoint. For Social Security Institutions in developing countries, it is very important to assess what drugs may decrease the subsequent use of medical care resources, considering their adverse events that are known to have a significant increase in medical care costs of patients with OA. Three treatment alternatives were compared: celecoxib (200 mg twice daily), non-selective NSAIDs (naproxen, 500 mg twice daily; diclofenac, 100 mg twice daily; and piroxicam, 20 mg/day) and acetaminophen, 1000 mg twice daily. The aim of this study was to identify the most cost-effective first-choice pharmacological treatment for the control of joint pain secondary to OA in patients treated at the Instituto Mexicano del Seguro Social (IMSS). Methods A cost-effectiveness assessment was carried out. A systematic review of the literature was performed to obtain transition probabilities. In order to evaluate analysis robustness, one-way and probabilistic sensitivity analyses were conducted. Estimations were done for a 6-month period. Results Treatment demonstrating the best cost-effectiveness results [lowest cost-effectiveness ratio $17.5 pesos/patient ($1.75 USD)] was celecoxib. According to the one-way sensitivity analysis, celecoxib would need to markedly decrease its effectiveness in order for it to not be the optimal treatment option. In the probabilistic analysis, both in the construction of the acceptability curves and in the estimation of net economic benefits, the most cost-effective option was celecoxib. Conclusion From a Mexican institutional perspective and probably in other Social Security Institutions in similar developing countries, the most cost-effective option for treatment of knee and/or hip OA would be celecoxib. PMID

  4. Líneas Vitales: Programas y servicios del NCI

    Cancer.gov

    Artículos y videos sobre los programas y servicios del Instituto Nacional del Cáncer de la serie educativa Líneas Vitales del NCI, la cual está dirigida especialmente a poblaciones multiculturales.

  5. Atlas del Genoma del Cáncer: Antecedentes

    Cancer.gov

    El Atlas del Genoma del Cáncer es una iniciativa de los Institutos Nacionales de la Salud (NIH) para crear mapas multidimensionales completos de los cambios genómicos clave en los tipos y subtipos principales de cáncer.

  6. Síntesis: Resultados iniciales del Estudio Nacional de Ex

    Cancer.gov

    El 4 de noviembre de 2010, el Estudio Nacional de Exámenes de Pulmóndio a conocer resultados iniciales que indican que hubo 20% menos muertes por cáncer de pulmón entre los participantes del estudio evaluados con tomografía computarizada espiral de baja d

  7. [The clinical guidelines of practice project at the Instituto Mexicano del Seguro Social].

    PubMed

    del Pilar Torres-Arreola, Laura; Peralta-Pedrero, María Luisa; Viniegra-Osorio, Arturo; Valenzuela-Flores, Adriana Abigail; Echevarría-Zuno, Santiago; Sandoval-Castellanos, Fernando J

    2010-01-01

    The advance in the knowledge and technology is growing quickly and greater quantity, so it is difficult for the health professional to access to whole information that is generated every day on diagnostic and therapeutic strategies more effective, so the clinic practice guidelines (CPG) is a resource to support the updating of the health professional and support them in making clinical decisions. The CPG is also a better support to the manager of health services in making decisions regarding the strategies that have performed for the patient and less risk to the individual and collective health. They also support the response capacity of the medical units and hospitals and guide the planning of services to the optimization of the resources. This paper summarizes the methodology of a national project for the development of GPC coordinated by the Mexican Social Security Institute with the collaboration of more than 1200 health professionals of the institution in a great effort institutional update and make information accessible to the entire health sector, which also defines the steps to upgrade and maintain the updating of knowledge and technology expressed in them.

  8. [The system of evaluating the specialty of pediatrics in the Instituto Mexicano del Seguro Social].

    PubMed

    Jasso-Gutiérrez, L; Serafín-Anaya, F; López-Fuentes, G; Arnaíz-Toledo, C

    1993-11-01

    A system of evaluation applied to pediatric residents at the Mexican Institute of Social Security (IMSS) is presented. Historical precedents; deficiencies and modifications of the system are commented. Also institutional system of evaluation is described, with emphasis in education strategies: teaching-attendance-research. Usefulness of knowledge tests, supervision, and assessment of evaluation, are mentioned. Finally extrainstitutional evaluation strategies are considered.

  9. Informe Anual a la Nación sobre el Estado del Cáncer, 1975 a 2012

    Cancer.gov

    El Informe Anual a la Nación sobre el Estado del Cáncer, 1975 a 2012, es una actualización de los índices de casos nuevos, muertes y tendencias de los cánceres más comunes en los Estados Unidos.

  10. [Recommendations to improve the scientific communication process in the Revista Médica del IMSS].

    PubMed

    Álvarez, Ivón

    2016-01-01

    In order to improve the position of the Revista Médica del Instituto Mexicano del Seguro Social among the different journals, in this editorial we enumerate a series of recommendations to ameliorate the practices of the different actors who participate in the scientific communication process of this journal.

  11. [Recommendations to improve the scientific communication process in the Revista Médica del IMSS].

    PubMed

    Álvarez, Ivón

    2016-01-01

    In order to improve the position of the Revista Médica del Instituto Mexicano del Seguro Social among the different journals, in this editorial we enumerate a series of recommendations to ameliorate the practices of the different actors who participate in the scientific communication process of this journal. PMID:26820191

  12. [Group psychotherapy. Operative groups at the Instituto del servico de seguridad Social de los Trabajadores del Estado (ISSSTE)].

    PubMed

    Margolis, J

    1977-01-01

    An operational group is defined; how operational groups theory was applied at an ISSSTE clinic is described. It is underlined how operational groups promote change around the corerstone of a "task". The vicissitudes of an operational group with four psychiatrists who worked in community psychiatry at the ISSSTE, are described.

  13. [Family psychotherapy in medical institutions of the Instituto del Servicio de Seguridad Social de los Trabajadores del Estado].

    PubMed

    Serrano, H

    1977-01-01

    The evolution of family therapy in Mexico is briefly reviewed. It is considered that the reach of this method is limited in institutions due to the lack of qualified psychotherapists with the different orientations of this speciality. The illness, as a sign of family imbalance within the humanistic concept, acquires an even if the treatment is given to the marital couple, the adolescent or the child. Family therapy helps in marital disagreements, behavior problems, anorexia, reactive depression, drug addictions, alcoholism and many other problems. The ISSSTE population has a stable location and is more or less homogeneous; in it family therapy is stimulating and possible; even though the institution imposes certain limitations to family therapy, the enthusiasm for this therapeutic method prevails.

  14. The Instituto de Astrofísica de Canarias: 30 years of Research and Communication in Astronomy.

    NASA Astrophysics Data System (ADS)

    Del Puerto, Carmen; Rodriguez, Nayra; Rosenberg, Alfred; Beckman, John Etienne

    2015-08-01

    1985 was a year of inauguration for the Instituto de Astrofísica de Canarias (IAC). In that year its two observatories, the Observatorio del Roque de los Muchachos, on the island of La Palma, (where its 10.4m optical-NIR telescope vies with the world´s major instruments), and the Observatorio del Teide, on the island of Tenerife, as well as its headquarters in La Laguna, Tenerife, were all inaugurated. This young institution has rapidly become the leading research centre for astronomy in Spain and achieved research standards at a European and world level. The 30th anniversary celebrations this year give an opportunity to maximize its already very active outreach programmes. In February two shows, featuring IAC researchers, and with astronomical themes, were shown in the main theatre of the city of La Laguna, and during the year further entertainment, collaborating with Canarian musicians and artists, is planned. Two exhibitions have been designed combining the anniversary with celebrations of the International Year of Light: “Listen to the Universe”, in Tenerife, and “Thirty Journeys around the Sun”, in La Palma, which will be open to the public for most of the year. A new outreach magazine “Parallaxes” will be launched by the IAC, in both paper and digital editions, and will complement the current blog, and news websites of the institute, as well as its communications on Facebook and Twitter. Among the activities being organized in Tenerife will be the formal naming of traffic circles with names of the telescopes at the Observatories. In conjunction with the municipal wine cellars of the local city of Tegueste a new Canarian wine produced by innovative methods and with an astronomical motif on its label, is to be launched during the year. All of these activities are in addition to the somewhat more routine productions of videos on the research lines of the IAC, including exoplanets, solar stellar, and interstellar physics, galaxies, and cosmology.

  15. Instituto de Astrofísica de Madrid: science fiction or top science?

    NASA Astrophysics Data System (ADS)

    Caballero, J. A.

    2015-05-01

    In Spain, there is an Instituto de Astrofísica de Canarias in Tenerife, an Instituto de Astrofísica de Andalucía in Granada and an Institut d'Estudis Espacials de Catalunya in Barcelona. However, there is not an Instituto de Astrofísica de Madrid (IAM). Actually, Madrilenian astronomers are spread over a number of institutions of quite different origin, size and funding source. The IAM, if it existed, would be a catalyzer of ideas and collaborations, an international meeting point, an engine for high-technology industry in the region, and an excellence centre. Furthermore, the IAM would maximise the efficiency in the use of resources, offer a place for finding synergies between research groups and, especially, have a critical mass for embarking in very large projects in the ground and space. I will expose how, in a smooth and democratic way, an IAM might be built step by step. The process may take decades and, thus, young Madrilenian astronomers shall play a rôle on it.

  16. Se lanza Red Nacional de Estudios Clínicos del NCI

    Cancer.gov

    El Instituto Nacional del Cáncer (NCI) puso en marcha una nueva red de investigación de estudios clínicos con el objetivo de mejorar el tratamiento de más de 1,6 millones de estadounidenses que reciben un diagnóstico de cáncer cada año.

  17. Resultados de estudio para cáncer de pulmón indica

    Cancer.gov

    El Instituto Nacional del Cáncer (NCI) da a conocer hoy resultados iniciales de un estudio de gran envergadura sobre métodos de detección para reducir el número de muertes por cáncer de pulmón al detectar cánceres en estadios relativamente iniciales.

  18. Overview of some biomedical research projects in tropical medicine conducted at the Instituto Venezolano de Investigaciones Cientificas.

    PubMed

    Romano, E; Cesari, I; Escalante, A; Liprandi, F; O'Daly, J A; Perez, H; Takiff, H

    2000-01-01

    The Instituto Venezolano de Investigaciones Cientificas (IVIC) is a government-funded multidisciplinary academic institution dedicated to research, development and technology in many areas of knowledge. Biomedical projects and publications comprise about 40% of the total at IVIC. In this article, we present an overview of some selected research and development projects conducted at IVIC which we believe contain new and important aspects related to malaria, ancylostomiasis, dengue fever, leishmaniasis and tuberculosis. Other projects considered of interest in the general area of tropical medicine are briefly described. This article was prepared as a small contribution to honor and commemorate the centenary of the Instituto Oswaldo Cruz.

  19. [Mesenteric cyst in the Instituto Nacional de Salud del Niño, Lima, Peru: a case report].

    PubMed

    Cucho, Janetliz; Ormeño, Alexis; Valdivieso Falcon, Lidia; Pereyra, Sonia; Ramos Rodríguez, Karen

    2013-01-01

    Mesenteric cysts are rare abdominal tumors. About 60% of these cysts occurs before 5 years of age and can be located anywhere in the gastrointestinal tract, but are most often found in the small bowel mesentery. The clinical presentation depends on the location and size of the cyst and many cases are asymptomatic and are diagnosed incidentally. The most common symptoms are abdominal pain, bloating, abdominal mass, nausea, vomiting, constipation, diarrhea, weight loss, fever and peritonitis. Complications include torsion, infarction, volvulus formation, perforation, infection, anemia, intracystic hemorrhage, intestinal obstruction and obstructive uropathy. They are typically treated by simple excision, marsupialization or segmental bowel resection and have excellent long-term prognosis.

  20. ["The Use and Control of Stress". A program applied to workers of the IMSS. Instituto Mexicano del Seguro Social].

    PubMed

    Maldonado-Islas, G; Mancera-Pérez, A A

    1997-01-01

    Stress, is considered to be a bodily response to both internal and environmental stimuli, is a live and unavoidable energy. It is important and necessary to learn to use it beneficially. In order to determine the utility of the educational program. "The use use and control of stress", a quasi-experimental study was conducted in 1993, in which 39 voluntary Zone I General Hospital (IMSS Tlaxcala State Delegation) workers were selected, based on stress levels over 3 points as found in an institutional validated to measure the stress level. Five groups were set up, and eight weekly educative interventions, composed of cognitive contents including stress, relaxation techniques, and techniques for living of 90 minutes each were attended by the members of these groups, utilizing groups dynamics. The results were analyzed in simple absolute and relative frequencies, as well as by Student's t tests. They show a reduction stress levels in 94.8% of the participants, which represents a 69.1% general gain, with p = < 0.005. The conclusion is that learning related with the use and control of stress is an alternative to improve the mental health of the individual and as concerns the work environment, to modify attitude of the IMSS worker.

  1. [Clindrical battery in the stomach in the Instituto Nacional de Salud del Niño, Lima, Peru].

    PubMed

    Alarcón Olivera, César; Ormeño Julca, Alexis

    2013-01-01

    The ingestion of foreign bodies (EC) is a problem commonly seen by pediatricians and emergency physicians. The intake is almost always accidental and most common objects are coins, pieces of toys, jewelry or batteries. The button batteries are the most common, in which case is important early diagnosis and removal. The cylindrical battery ingestion is very rare, are typically alkaline manganese or nickel-cadmium (rechargeable) and when ingested they can cause toxic and corrosive damage. Such damage may occur as a result of the effect of acid gastric contents sustained over a period of days or weeks. We report the case of a patient who accidentally ingested a cylindrical battery, which was removed from the stomach endoscopically without complications.

  2. Silent gains: Instituto Buena Bista and art as catalyst among Curaçaoan youth.

    PubMed

    González, Iberia Pérez

    2010-01-01

    Considering the limited opportunities and resources for creative education, artists David Bade and Tirzo Martha, along with art historian Nancy Hoffmann, developed a dynamic platform to support creative young talent on the Dutch Caribbean island of Curaçao. The aim of Instituto Buena Bista (IBB), founded in 2006, is to strengthen the arena of culture and the visual arts by offering young Curaçaoans a basic but thorough course in art education that is meant to function as a springboard to more advanced art schools. With only two years of operation, the IBB is already seeing how some of its students go to art academies abroad and participate in art contests in the Netherlands. An exploration of how the IBB is filling up a cultural void by proposing an alternative to local youth education that allows them to develop a buena bista-a new and different view of their island, their futures, and themselves.

  3. Innovations in graduate public health education: the Instituto Nacional de Salud Pública.

    PubMed

    Valladares, Laura Magaña; Ávila, Mauricio Hernández

    2015-03-01

    During the past 10 years, the Instituto Nacional de Salud Pública (National Institute of Public Health) in Mexico has meticulously revised its educational model. This analysis resulted in the transformation of its educational model by tracing a new path in the pedagogical structure and faculty development to meet current challenges and students' needs. The first stage dealt with the national and international accreditation standards that came with the 21st century. The second stage responded to evidence of cognitive research showing that students are better prepared when they are engaged, active, and responsible for their own learning. This transformation was grounded on the use of information and communication technologies and on a competency-based educational approach that has led the expansion and innovation of educational practice. PMID:25706028

  4. Innovations in graduate public health education: the Instituto Nacional de Salud Pública.

    PubMed

    Valladares, Laura Magaña; Ávila, Mauricio Hernández

    2015-03-01

    During the past 10 years, the Instituto Nacional de Salud Pública (National Institute of Public Health) in Mexico has meticulously revised its educational model. This analysis resulted in the transformation of its educational model by tracing a new path in the pedagogical structure and faculty development to meet current challenges and students' needs. The first stage dealt with the national and international accreditation standards that came with the 21st century. The second stage responded to evidence of cognitive research showing that students are better prepared when they are engaged, active, and responsible for their own learning. This transformation was grounded on the use of information and communication technologies and on a competency-based educational approach that has led the expansion and innovation of educational practice.

  5. Catalogue of the type material of Phlebotominae (Diptera, Psychodidae) deposited in the Instituto Evandro Chagas, Brazil

    PubMed Central

    dos Santos, Thiago Vasconcelos; Pinheiro, Maria Sueli Barros; de Andrade, Andrey José

    2014-01-01

    Abstract The available type material of Phlebotominae (Diptera, Psychodidae) deposited in the “Coleção de Flebotomíneos” of the Instituto Evandro Chagas (ColFleb IEC) is now presented in an annotated catalogue comprising a total of 121 type specimens belonging to 12 species as follow: Nyssomyia richardwardi (2 female paratypes), Nyssomyia shawi (9 male and 25 female paratypes), Nyssomyia umbratilis (female holotype and 1 female paratype), Nyssomyia yuilli yuilli (1 male and 1 female paratypes), Pintomyia gruta (1 male and 2 female paratypes), Psychodopygus lainsoni (2 male syntypes), Psychodopygus leonidasdeanei (male holotype, female “allotype” and 45 female paratypes), Psychodopygus llanosmartinsi (2 female paratypes), Psychodopygus wellcomei (1 male and 4 female “syntypes”), Trichophoromyia readyi (male holotype, female “allotype” and 1 male paratype), Trichophoromyia adelsonsouzai (male holotype, 13 male 5 female paratypes), and Trichophoromyia brachipyga (1 male paratype). PMID:24715786

  6. [Instituto Oswaldo Cruz scientific publication from 1900 to 1917, an exploratory study].

    PubMed

    Weltman, Wanda Latmann

    2002-01-01

    The present article is an exploratory study on the scientific material published by Instituto Oswaldo Cruz (IOC) from 1900 to 1917. It aims at characterizing the initial production of the institute and its scientists' concern with information. In order to characterize such production, publication data and citation analysis have been used. Through a comparative analysis of publication data and their citations by other scientists, the author evaluates part of IOC scientists' behavior towards the quality of products and as information users. The present study builds up a general view of those scientists' areas of activities and interests in the period 1900-1917 and characterizes part of their role as information producers and users.

  7. Observations with the Real Instituto y Observatorio de la Armada CCD transit circle in Argentina

    NASA Astrophysics Data System (ADS)

    Muiños, J. I.; Belizón, F.; Vallejo, M.; Mallamaci, C.; Pérez, J. A.

    The Real Instituto y Observatorio de la Armada (ROA) meridian circle was moved to the Estación de Altura Carlos Ulrrico Cesco in the República Argentina in 1996. Until November 1999 the observations were carried out with a moving slit micrometer. In spring 2001 the result of these observations has been published, forming the first Hispano-Argentinian Meridian Catalogue (HAMC). In December 1999 was installed a SpectraSource CCD camera of 1552×1024 pixels of 9 μ. The CCD camera observes in drift scan mode. A survey of the southern hemisphere is being observed from +3° to -60° of declination. In this contribution is presented a description of the telescope and the automatic control system, the results of observations carried out with the slit micrometer, and the observational and preliminary reduction techniques with the CCD camera, the present state of the southern hemisphere survey and the future possibilities.

  8. Ambient Dose Equivalent measured at the Instituto Nacional de Cancerologia Department of Nuclear Medicine

    SciTech Connect

    Avila, O.; Torres-Ulloa, C. L.; Medina, L. A.; Trujillo-Zamudio, F. E.; Gamboa de Buen, I.; Buenfil, A. E.; Brandan, M. E.

    2010-12-07

    Ambient dose equivalent values were determined in several sites at the Instituto Nacional de Cancerologia, Departmento de Medicina Nuclear, using TLD-100 and TLD-900 thermoluminescent dosemeters. Additionally, ambient dose equivalent was measured at a corridor outside the hospitalization room for patients treated with {sup 137}Cs brachytherapy. Dosemeter calibration was performed at the Instituto Nacional de Investigaciones Nucleares, Laboratorio de Metrologia, to known {sup 137}Cs gamma radiation air kerma. Radionuclides considered for this study are {sup 131}I, {sup 18}F, {sup 67}Ga, {sup 99m}Tc, {sup 111}In, {sup 201}Tl and {sup 137}Cs, with main gamma energies between 93 and 662 keV. Dosemeters were placed during a five month period in the nuclear medicine rooms (containing gamma-cameras), injection corridor, patient waiting areas, PET/CT study room, hot lab, waste storage room and corridors next to the hospitalization rooms for patients treated with {sup 131}I and {sup 137}Cs. High dose values were found at the waste storage room, outside corridor of {sup 137}Cs brachytherapy patients and PET/CT area. Ambient dose equivalent rate obtained for the {sup 137}Cs brachytherapy corridor is equal to (18.51{+-}0.02)x10{sup -3} mSv/h. Sites with minimum doses are the gamma camera rooms, having ambient dose equivalent rates equal to (0.05{+-}0.03)x10{sup -3} mSv/h. Recommendations have been given to the Department authorities so that further actions are taken to reduce doses at high dose sites in order to comply with the ALARA principle (as low as reasonably achievable).

  9. [Anorexia-cachexia frequency and its gastrointestinal symptoms association in paliative patients at the Instituto Nacional de Cancerología, México].

    PubMed

    Pérez Camargo, Dana Aline; Allende Pérez, Silvia R; Meneses García, Abelardo; De Nicola Delfin, Luigina; Copca Mendoza, Erika Thalía; Sánchez López, Miriam S; Flores García, Martha Karen; Verástegui Avilés, Emma

    2014-10-01

    Introducción: La anorexia-caquexia es un síndrome frecuente en pacientes oncológicos, particularmente en etapas avanzadas: la prevalencia global de anorexia-caquexia para-neoplásica oscila entre el 20-40% en los enfermos en la fase diagnóstica, y entre el 70–80% en la fase avanzada de la enfermedad. En los enfermos oncológicos es frecuente la coexistencia de alteraciones digestivas estructurales o funcionales, secundarias al crecimiento tumoral y a los fenómenos sistémicos de carácter metabólico, determinados por la interrelación tumor-huésped específicos de la anorexia-caquexia. Objetivo: El objetivo de este trabajo es conocer la frecuencia de anorexia-caquexia, y su asociación con síntomas gastrointestinales en pacientes en terreno paliativo del Instituto Nacional de Cancerología, Ciudad de México, atendidos en el servicio de Cuidados Paliativos. Material y métodos: Se realizó un estudio transversal analítico. Se incluyeron 100 pacientes con diagnóstico de cáncer avanzado, con un rango de edad de 18 y 80 años, y una puntuación de Karnofsky > 50, así como un ECOG.

  10. Volcano Monitoring in Ecuador: Three Decades of Continuous Progress of the Instituto Geofisico - Escuela Politecnica Nacional

    NASA Astrophysics Data System (ADS)

    Ruiz, M. C.; Yepes, H. A.; Hall, M. L.; Mothes, P. A.; Ramon, P.; Hidalgo, S.; Andrade, D.; Vallejo Vargas, S.; Steele, A. L.; Anzieta, J. C.; Ortiz, H. D.; Palacios, P.; Alvarado, A. P.; Enriquez, W.; Vasconez, F.; Vaca, M.; Arrais, S.; Viracucha, G.; Bernard, B.

    2014-12-01

    In 1988, the Instituto Geofisico (IG) began a permanent surveillance of Ecuadorian volcanoes, and due to activity on Guagua Pichincha, SP seismic stations and EDM control lines were then installed. Later, with the UNDRO and OAS projects, telemetered seismic monitoring was expanded to Tungurahua, Cotopaxi, Cuicocha, Chimborazo, Antisana, Cayambe, Cerro Negro, and Quilotoa volcanoes. In 1992 an agreement with the Instituto Ecuatoriano de Electrificacion strengthened the monitoring of Tungurahua and Cotopaxi volcanoes with real-time SP seismic networks and EDM lines. Thus, background activity levels became established, which was helpful because of the onset of the 1999 eruptive activity at Tungurahua and Guagua Pichincha. These eruptions had a notable impact on Baños and Quito. Unrest at Cotopaxi volcano was detected in 2001-2002, but waned. In 2002 Reventador began its eruptive period which continues to the present and is closely monitored by the IG. In 2006 permanent seismic BB stations and infrasound sensors were installed at Tungurahua and Cotopaxi under a cooperative program supported by JICA, which allowed us to follow Tungurahua's climatic eruptions of 2006 and subsequent eruptions up to the present. Programs supported by the Ecuadorian Secretaria Nacional de Ciencia y Tecnologia and the Secretaria Nacional de Planificacion resulted in further expansion of the IG's monitoring infrastructure. Thermal and video imagery, SO2 emission monitoring, geochemical analyses, continuous GPS and tiltmeters, and micro-barometric surveillance have been incorporated. Sangay, Soche, Ninahuilca, Pululahua, and Fernandina, Cerro Azul, Sierra Negra, and Alcedo in the Galapagos Islands are now monitored in real-time. During this time, international cooperation with universities (Blaise Pascal & Nice-France, U. North Carolina, New Mexico Tech, Uppsala-Sweden, Nagoya, etc.), and research centers (USGS & UNAVCO-USA, IRD-France, NIED-Japan, SGC-Colombia, VAAC, MIROVA) has introduced

  11. [Frequency of congenital anomalies at the Instituto Materno Infantil, Bogota, Colombia].

    PubMed

    García, Herbert; Salguero, Gustavo Andrés; Moreno, Jeffer; Arteaga, Clara; Giraldo, Alejandro

    2003-06-01

    At the Instituto Materno Infantil (IMI) in Bogotá (Colombia), 5,686 births (5,597 live births and 89 stillbirths) were analyzed during two periods: from October, 1997, to April, 1998, and from July to November, 2000 (12 months). Congenital anomalies were detected in 4.4% of live newborn babies and in 7.8% of stillbirths. Major anomalies corresponded to 69% and mild anomalies to 31% (3% and 1.4% of all live births, respectively). The newborn babies with major anomalies, in comparison to the normal controls, had higher mortality at hospital discharge (p = 0.0001), lower average birth weight (p = 0.003), and family history of congenital anomalies (p = 0.0001). The only significant association for mild anomalies was with family history of congenital anomalies (p = 0.0001). The frequency of congenital anomalies was similar to that in other studies, although certain kinds of anomalies showed noticeable frequency differences. This may be a consequence of differences in record keeping or in detection methods.

  12. Clinical experience with electroconvulsive therapy at the Instituto Mexicano de Psiquiatría.

    PubMed

    Sánchez de Carmona Luna Y Parra, M; Páez Agraz, F; Nicolini Sánchez, H

    1996-01-01

    Electroconvulsive therapy (ECT) is a useful option for the treatment of certain psychiatric illnesses. Its efficacy and few side effects make it an important therapeutic alternative in the management of the patient with major depression. This study describes the clinical experience with ECT at the Instituto Mexicano de Psiquiatría. We retrospectively evaluated the clinical records of patients treated with ECT during the period of April 1990 to June 1994. A total of 55 patients were included in the analysis, the mean age was 42.4 +/- 17.2 years old. Diagnostic categories treated were major depression (43.6%), non-affective psychotic disorders (30.9%), mania (12.7%) and other diagnoses (12.7%). A positive response to ECT was found in 74.5% of patients. Subjects with major depression and mania responded significantly better than the rest of the patients (p < 0.01). Psychotic depression was not a predictor of better response. Only 18.1% of subjects had minor complications, all transitory. ECT is a highly effective therapeutic option in the treatment of psychiatric illness, especially in major depression and mania. The use of ECT in a tertiary psychiatric unit in Mexico reflects similar results as described in the international literature.

  13. [Group psychotherapy. Experience with a changing process at a clinic of the Instituto del Servicio de Seguridad Social de los Trabajadores del Estado (ISSSTE)].

    PubMed

    Velasco de Ongay, M E

    1977-01-01

    The problems of an ISSSTE clinic were approached within the general systems theory and it was observed that within the group there existed forces to maintain the status-quo and forces towards change; to produce the latter the group was handled during 20 hours with a slightly directive technique. The goals were to improve interpersonal relationships, to increase communication, to make known to individuals their attitudes within a group and make them sensitive to problems they shared with others. The results were good, the status-quo was broken and change started occurring.

  14. Profile of patients with Baggio-Yoshinari Syndrome admitted at "Instituto de Infectologia Emilio Ribas".

    PubMed

    Gouveia, Emy Akiyama; Alves, Mayra Fernanda; Mantovani, Elenice; Oyafuso, Luiza Keiko; Bonoldi, Virgínia Lucia Nazario; Yoshinari, Natalino Hajime

    2010-01-01

    The aim of this study was to evaluate the epidemiological, clinical and laboratorial profile of patients with Baggio-Yoshinari Syndrome (BYS), who underwent internment at the Instituto de Infectologia Emilio Ribas in São Paulo, Brazil, during the period from July 1990 to July 2006. BYS is a new Brazilian tick-borne disease caused by Borrelia burgdorferi sensu lato microorganisms that resembles features of Lyme disease (LD), except for its epidemiological, clinical and laboratorial particularities. From 60 patients' records with positive serology to B. burgdorferi done by ELISA and Western-blotting methods, 19 cases were diagnosed as having BYS, according to criteria adopted at LIM-17 HCFMUSP, the Brazilian Reference Laboratory for the research of BYS. The other 41 remaining patients displayed miscellaneous infections or auto-immune processes. The beginning of symptoms in BYS group varied from one day to six years, from the onset of the disease. Four of 19 patients were included in acute disease stage, and 15 in latent. General unspecific symptoms were identified in almost all cases, with high frequencies of fever (78.9%) and lymphadenomegaly (36.8%). Six patients had skin lesions (31.5%); six arthralgia or arthritis (31.5%) and eight neurological symptoms (42%). Interestingly, two patients showed antibodies directed to B. burgdorferi exclusively in cerebrospinal fluid. Since BYS is a new emergent Brazilian zoonosis and its diagnosis is sometimes complex, all the new knowledge about BYS must be scattered to Brazilian Medical specialists, aiming to teach them how to diagnose this amazing tick-borne disease and to avoid its progression to chronic irreversible sequels.

  15. Radio-Observaciones del OH EN la Coma del Cometa Halley Desde EL Hemisferio Sur

    NASA Astrophysics Data System (ADS)

    Silva, A. M.; Bajaja, E.; Morras, R.; Cersosimo, J. C.; Martin, M. C.; Arnal, E. M.; Poppel, W. G. L.; Colomb, F. R.; Mazzaro, J.; Olalde, J. C.; Boriakoff, V.; Mirabel, I. F.

    1987-05-01

    Se utilizó una antena de 30 metros del Instituto Argentino de Radioastronomía para observaciones diarias Cf ebrero a abril de 1986) de la transición en 1667 MHz ( λ = 18 cm) del OH en la coma del cometa Halley. De las observaciones realizadas se concluye: 1) El número promedio de moléculas de OH en la coma durante 37 días de observación fue de (8.9±3.5)x1034 moléculas, lo que implica una tasa de producción promedio de OH de 1.8x1029 moléculas seg-1 y consecuentemente una pérdida de masa promedio de 17±6 toneladas seg-1 . Este valor está de acuerdo con las mediciones realizadas por las sondas Vega y Giotto. 2) El monitoreo desde el lAR revela la existencia de variaciones bruscas en los flujos de absorción del OH. Estas variaciones son consistentes con los modelos que representan la producción gaseosa a partir de ejecciones y/o desprendimientos discretos de materia congelada del núcleo. 3) Las variaciones en la densidad de flujo son consistentes con las estimaciones de los tiem- pos de vida medios del H2O y del OH en presencia del campo de radiación solar. 4) Se encuentra una correlación entre la intensidad del flujo absorbido y anisotropías en Ia dinamica de la coma.

  16. Effect of artificial feeders on pollen loads of the hummingbirds of Cerro de la Muerte, Costa Rica.

    PubMed

    Avalos, Gerardo; Soto, Alejandra; Alfaro, Willy

    2012-03-01

    Although sugar-water feeders are commonly used by enthusiasts to attract hummingbirds, little is known about how they affect hummingbird behavior and flower use. We studied the highland hummingbird assemblage of Cerro de La Muerte, Costa Rica, both at a site with permanent feeders (La Georgina Restaurant) and further from it. We examined how feeder use and monopolization affected seasonal changes in pollen loads during four sampling periods, including dry and wet seasons, from 2003-2005. We expected that species monopolizing the feeders would carry little or no pollen whatsoever, and would have pollen loads characterized by low floral diversity, in contrast with species less dependent on feeders. We obtained pollen samples from 183 individuals of four hummingbird species captured around the feeders using mist nets, which were compared with a pollen reference collection of plants with a pollination syndrome by hummingbirds. The same methods were implemented at a site 3km away from the feeders. Feeder usage was quantified by counting the number of times hummingbirds drank from the feeders in periods of 4min separated by 1min. The effects of hummingbird species and season on pollen load categories were assessed using a nominal logistic regression. The alpha species at the site, the Fiery-throated Hummingbird (Panterpe insignis), dominated the feeders during the dry season. Meanwhile, in the wet season, feeder usage was more evenly distributed across species, with the exception of the Volcano Hummingbird, Selasphorus flammula, which occupies the last place in the dominance hierarchy. Pollen loads of hummingbirds captured near feeders were low in abundance (more than 50% of captured individuals had zero or low pollen loads), and low in species richness (96% of the hummingbirds with pollen from only one plant genus, Centropogon). Overall pollen loads increased during the dry season coinciding with peaks in flower availability, although the majority of captured

  17. Effect of artificial feeders on pollen loads of the hummingbirds of Cerro de la Muerte, Costa Rica.

    PubMed

    Avalos, Gerardo; Soto, Alejandra; Alfaro, Willy

    2012-03-01

    Although sugar-water feeders are commonly used by enthusiasts to attract hummingbirds, little is known about how they affect hummingbird behavior and flower use. We studied the highland hummingbird assemblage of Cerro de La Muerte, Costa Rica, both at a site with permanent feeders (La Georgina Restaurant) and further from it. We examined how feeder use and monopolization affected seasonal changes in pollen loads during four sampling periods, including dry and wet seasons, from 2003-2005. We expected that species monopolizing the feeders would carry little or no pollen whatsoever, and would have pollen loads characterized by low floral diversity, in contrast with species less dependent on feeders. We obtained pollen samples from 183 individuals of four hummingbird species captured around the feeders using mist nets, which were compared with a pollen reference collection of plants with a pollination syndrome by hummingbirds. The same methods were implemented at a site 3km away from the feeders. Feeder usage was quantified by counting the number of times hummingbirds drank from the feeders in periods of 4min separated by 1min. The effects of hummingbird species and season on pollen load categories were assessed using a nominal logistic regression. The alpha species at the site, the Fiery-throated Hummingbird (Panterpe insignis), dominated the feeders during the dry season. Meanwhile, in the wet season, feeder usage was more evenly distributed across species, with the exception of the Volcano Hummingbird, Selasphorus flammula, which occupies the last place in the dominance hierarchy. Pollen loads of hummingbirds captured near feeders were low in abundance (more than 50% of captured individuals had zero or low pollen loads), and low in species richness (96% of the hummingbirds with pollen from only one plant genus, Centropogon). Overall pollen loads increased during the dry season coinciding with peaks in flower availability, although the majority of captured

  18. Uneasy money: the Instituto Carlos Slim de la Salud, tobacco philanthropy and conflict of interest in global health

    PubMed Central

    Burch, Tiffany; Wander, Nathaniel; Collin, Jeff

    2015-01-01

    In May 2007, the Instituto Carso de la Salud—now Instituto Carlos Slim de la Salud (ICSS)—was endowed with US$500 million to focus on priority health issues in Latin America, notably issues of ‘globalisation and non-communicable diseases’. ICSS was soon criticised, however, on the grounds that its funding was derived from tobacco industry profits and that its founder Carlos Slim Hélu remained an active industry principal. Collaboration with ICSS was said to run counter to the WHO Framework Convention on Tobacco Control. The Institute's then Executive President Julio Frenk disputed these charges. This research employs an archive of tobacco industry documents triangulated with materials from commercial, media, regulatory and NGO sources to examine the financial relations between Slim and the tobacco industry. The paper analyses Slim's continuing service to the industry and role in ICSS. It demonstrates a prima facie conflict of interest between ICSS's health mission and its founder's involvement in cigarette manufacturing and marketing, reflected on ICSS's website as a resounding silence on issues of tobacco and health. It is concluded that the reliance of international health agencies upon the commercial sector requires more robust institutional policies to effectively regulate conflicts of interest. PMID:21088061

  19. Uneasy money: the Instituto Carlos Slim de la Salud, tobacco philanthropy and conflict of interest in global health.

    PubMed

    Burch, Tiffany; Wander, Nathaniel; Collin, Jeff

    2010-12-01

    In May 2007, the Instituto Carso de la Salud-now Instituto Carlos Slim de la Salud (ICSS)-was endowed with US$500 million to focus on priority health issues in Latin America, notably issues of 'globalisation and non-communicable diseases'. ICSS was soon criticised, however, on the grounds that its funding was derived from tobacco industry profits and that its founder Carlos Slim Hélu remained an active industry principal. Collaboration with ICSS was said to run counter to the WHO Framework Convention on Tobacco Control. The Institute's then Executive President Julio Frenk disputed these charges. This research employs an archive of tobacco industry documents triangulated with materials from commercial, media, regulatory and NGO sources to examine the financial relations between Slim and the tobacco industry. The paper analyses Slim's continuing service to the industry and role in ICSS. It demonstrates a prima facie conflict of interest between ICSS's health mission and its founder's involvement in cigarette manufacturing and marketing, reflected on ICSS's website as a resounding silence on issues of tobacco and health. It is concluded that the reliance of international health agencies upon the commercial sector requires more robust institutional policies to effectively regulate conflicts of interest.

  20. [Influence of Instituto Mexicano de Seguro Social in the general mortality (1990-2005)].

    PubMed

    Fernández-Cantón, Soni

    2010-01-01

    The epidemiologic transition moves mortality towards the chronic diseases as the main causes and the elderly groups as their main targets. The Institute Mexican del Seguro Social (IMSS) contributes with 3 of every 10 deaths reported in the country. Mortality rates in men increased from 330.1 x 100,000 in 1990 to 485.4 in 2005. In women rates grew from 249.9 to 405.5 in the same period. Mortality patterns show a mayor contribution by the northern region and are different with regard to sex and age groups. The group under 20 years old have a lower contribution to mortality during the period studied. In the population insured by IMSS, the 60 to 79 age group in both sexes contributes with a major proportion of deaths.

  1. Contributions of the Instituto Nacional de Cardiología in the diagnosis and treatment of the Wolff-Parkinson - White syndrome.

    PubMed

    Iturralde-Torres, Pedro; Márquez, Manlio F

    2010-01-01

    Since the first description of the disease now known as Wolff-Parkinson-White syndrome, much knowledge has been gained through several experimental and clinical studies all over the world. The Instituto Nacional de Cardiología Ignacio Chávez in Mexico City has not been the exception. In this report, we describe the clinical, electrocardiographic and electrophysiologic contributions of past and present researchers at the Institute, as well as the experience in the diagnosis and treatment of the W-P-W syndrome at this Instituto Nacional de Cardiología Ignacio Chávez.

  2. Catalogue of Opiliones (Arachnida) types deposited in the Arachnida and Myriapoda collection of the Instituto Butantan, São Paulo, Brazil.

    PubMed

    Coronato-Ribeiro, Amanda; Pinto-Da-Rocha, Ricardo; Rheims, Cristina Anne

    2013-01-01

    A catalogue of the Opiliones types of the "Instituto Butantan", São Paulo, Brazil is given, surveying the collection after severe fire damaged in 2010. Of a total of 91 species with type material listed for the collection, 69 could be located, and 22 are considered lost. The species are arranged according to their families and genera. The collection of Salvador de Toledo Piza Jr., housed at the Museu de Zoologia "Luiz de Queiroz", was donated to the Instituto Butantan in 2009. These types received a new accession number and are listed under this new affiliation for the first time.

  3. CONTAMINACIÓN AMBIENTAL, VARIABILIDAD CLIMÁTICA Y CAMBIO CLIMÁTICO: UNA REVISIÓN DEL IMPACTO EN LA SALUD DE LA POBLACIÓN PERUANA

    PubMed Central

    Gonzales, Gustavo F.; Zevallos, Alisson; Gonzales-Castañeda, Cynthia; Nuñez, Denisse; Gastañaga, Carmen; Cabezas, César; Naeher, Luke; Levy, Karen; Steenland, Kyle

    2015-01-01

    RESUMEN El presente artículo es una revisión sobre la contaminación del agua, el aire y el efecto del cambio climático en la salud de la población peruana. Uno de los principales contaminantes del aire es el material particulado menor de 2,5 μ (PM 2,5), en la ciudad de Lima, anualmente 2300 muertes prematuras son atribuibles a este contaminante. Otro problema es la contaminación del aire domiciliario por el uso de cocinas con combustible de biomasa, donde la exposición excesiva a PM 2,5 dentro de las casas es responsable de aproximadamente 3000 muertes prematuras anuales entre adultos, con otro número desconocido de muertes entre niños debido a infecciones respiratorias. La contaminación del agua tiene como principales causas los desagües vertidos directamente a los ríos, minerales (arsénico) de varias fuentes, y fallas de las plantas de tratamiento. En el Perú, el cambio climático puede impactar en la frecuencia y severidad del fenómeno de El Niño oscilación del sur (ENSO) que se ha asociado con un incremento en los casos de enfermedades como cólera, malaria y dengue. El cambio climático incrementa la temperatura y puede extender las áreas afectadas por enfermedades transmitidas por vectores, además de tener efecto en la disponibilidad del agua y en la contaminación del aire. En conclusión, el Perú, pasa por una transición de factores de riesgo ambientales, donde coexisten riesgos tradicionales y modernos, y persisten los problemas infecciosos y crónicos, algunos de los cuales se asocian con problemas de contaminación de agua y de aire. PMID:25418656

  4. [Instituto de Investigaciones Clinicas "Dr. Américo Negrette": 55 years of excellent research versus global economic recession].

    PubMed

    Valero Cedeño, Nereida Josefina

    2014-12-01

    The Instituto de Investigaciones Clínicas "Dr. Américo Negrette" belongs to the Faculty of Medicine at University of Zulia in Maracaibo, Zulia State, Venezuela. It was created on December 4, 1959 by Dr. Américo Negrette. Today, with 55 years of existence, the Institute seeks to fulfill the mission that characterizes it, based on the values instilled by its founder and maintained by subsequent generations, whose research projects are implemented through seven research sections: Biochemistry, Hematologic Research, Neuropharmacology and Neuroscience, Immunology and Cell Biology, Clinical Neurochemistry, Parasitology and Virology. The research originated in these laboratories have become national and international points of reference, despite the current economic situation with budget deficits that put at risk the quality and originality of their projects with negative consequences on the productivity and applications for health population, reasons of biomedical research.

  5. Ambient Dose Equivalent measured at the Instituto Nacional de Cancerología Department of Nuclear Medicine

    NASA Astrophysics Data System (ADS)

    Ávila, O.; Torres-Ulloa, C. L.; Medina, L. A.; Trujillo-Zamudio, F. E.; de Buen, I. Gamboa; Buenfil, A. E.; Brandan, M. E.

    2010-12-01

    Ambient dose equivalent values were determined in several sites at the Instituto Nacional de Cancerología, Departmento de Medicina Nuclear, using TLD-100 and TLD-900 thermoluminescent dosemeters. Additionally, ambient dose equivalent was measured at a corridor outside the hospitalization room for patients treated with 137Cs brachytherapy. Dosemeter calibration was performed at the Instituto Nacional de Investigaciones Nucleares, Laboratorio de Metrología, to known 137Cs gamma radiation air kerma. Radionuclides considered for this study are 131I, 18F, 67Ga, 99mTc, 111In, 201Tl and 137Cs, with main gamma energies between 93 and 662 keV. Dosemeters were placed during a five month period in the nuclear medicine rooms (containing gamma-cameras), injection corridor, patient waiting areas, PET/CT study room, hot lab, waste storage room and corridors next to the hospitalization rooms for patients treated with 131I and 137Cs. High dose values were found at the waste storage room, outside corridor of 137Cs brachytherapy patients and PET/CT area. Ambient dose equivalent rate obtained for the 137Cs brachytherapy corridor is equal to (18.51±0.02)×10-3 mSv/h. Sites with minimum doses are the gamma camera rooms, having ambient dose equivalent rates equal to (0.05±0.03)×10-3 mSv/h. Recommendations have been given to the Department authorities so that further actions are taken to reduce doses at high dose sites in order to comply with the ALARA principle (as low as reasonably achievable).

  6. Instituto para la Promocion de la Cultura Civica, A.C.: Mission; Philosophy; Goals and Objectives; Challenge and Commitment; Activities; Publications and Essays; Presence in the Mass Media.

    ERIC Educational Resources Information Center

    Instituto para la Promocion de la Cultura Civica. Mexico City (Mexico).

    The report discusses the activities of the Instituto para la Promocion de la Culture Civica (ICC), a non-partisan, not-for-profit Mexican nongovernmental organization (NGO) that has as its mission: to promote the advancement of a civic culture understood as a system of values, ideas, traits of character, dispositions, inclinations, attitudes,…

  7. [Severe malnutrition: epidemiological and clinical characteristics of children hospitalized in the Instituto Materno Infantil de Pernambuco (IMIP), Brazil].

    PubMed

    Falbo, Ana Rodrigues; Alves, João Guilherme Bezerra

    2002-01-01

    Ninety-nine children admitted to the Instituto Materno Infantil de Pernambuco with severe malnutrition from May 1999 to May 2000 were investigated in a cross-sectional study focusing on key epidemiological and clinical variables. The majority of the children (88.9%) were less than 6 months of age, 42.4% had a history of low birth weight, and 36.4% were premature. Some 19.2% had never been breastfed, and 49.5% had been breastfed for less than 2 months. Some 15.2% of the mothers were illiterate. Most of the families (86.1%) had incomes less than twice the minimum wage (approximately US$150/month), and 51.5% had migrated from rural areas. Only 26.3% of the homes had running water, and 40.4% lacked sewage disposal facilities. Diarrhea was the reason for hospital admission in 55.6% of the cases. Hospital mortality was 34.3% in this group.

  8. Clinical-epidemiological profile of children with schistosomal myeloradiculopathy attended at the Instituto Materno-Infantil de Pernambuco.

    PubMed

    Araújo, Karina Conceição G M; Rosa e Silva, Cristiana da; Barbosa, Constança Simões; Ferrari, Teresa C A

    2006-09-01

    The most critical phase of exposure to schistosomal infection is the infancy, because of the more frequent contact with contaminated water and the immaturity of the immune system. One of the most severe presentations of this parasitosis is the involvement of the spinal cord, which prognosis is largely dependent on early diagnosis and treatment. Reports on this clinical form of schistosomiasis in children are rare in the literature. We present here the clinical-epidemiological profile of schistosomal myeloradiculopathy (SMR) from ten children who were admitted at the Instituto Materno-Infantil de Pernambuco over a five-year period. They were evaluated according to an investigation protocol. Most of these patients presented an acute neurological picture which included as the main clinical manifestations: sphincteral disorders, low back and lower limbs pain, paresthesia, lower limbs muscle weakness and absence of deep tendon reflex, and impairment of the gait. The diagnosis was presumptive in the majority of the cases. This study emphasizes the importance of considering the diagnosis of SMR in pediatric patients coming from endemic areas who present a low cord syndrome, in order to start the appropriate therapy and avoid future complications.

  9. [Retrospective evaluation of 500 endoscopic cholangiopancreatographies performed at the Instituto Nacional de la Nutrición "Salvador Zubiran"].

    PubMed

    Elizondo, J; Gallo, S; Valdovinos, M A; Paez, R

    1989-01-01

    We evaluated 500 endoscopic retrograde cholangiopancreatographies (ERCP) performed on 422 patients during a 5-year period in the Gastrointestinal Endoscopy Department, Instituto Nacional de la Nutrición Salvador Zubirán, México, D.F. ERCP combines endoscopic and radiologic techniques in order to obtain high quality opacification of pancreatic and biliary ducts. The rate of success for cannulation was 90%; desired duct opacification was possible in 89%. The most frequent indication for ERCP was to establish the differential diagnosis for jaundice; biliary stones in the common bile duct was the most frequent diagnosis, followed by normal biliary ducts. Pancreatography was normal in 74% of patients. ERCP complications were detected in 5.6%; fever and transient pain was the most common complaint in 1.6%. Mortality attributable to the procedure was 0.8%. From histological corroboration of cases by surgery or postmortem studies, diagnostic sensitivity was 92%, specificity 76%, positive predictive value 96% and a prevalence of 89%. We conclude that ERCP is highly sensitive and specific in diagnosing bilio-pancreatic-duodenal disease. Our results are comparable to other's experiences published throughout the world.

  10. [4 cases of annular pancreas at the Instituto Nacional de la Nutrición Salvador Zubirán].

    PubMed

    Maroun Marun, C; Uscanga, L; Robles-Díaz, G; Campuzano Fernández, M

    1992-01-01

    Annular pancreas (AP) is a rare congenital anomaly due to malrotation of the pancreatic ventral yolk. Although it has been described in young and middle age adults it predominates in children. Its clinical picture is that of duodenal obstruction or acute pancreatitis episodes. In this paper we report four cases of AP that were seen at the Instituto Nacional de la Nutricion Salvador Zubiran in Mexico City. Three were females and three were less than twenty years old. In one case the diagnosis was established at birth and the operation done in another hospital. In another patient a diagnosis of pyloric hypertrophy was made and a pyloroplasty was performed. This young man was admitted in our hospital because of abdominal pain and hyperamylasemia. An eighty four year old woman was seen due to abdominal pain, nausea and vomit. In all cases the diagnosis of AP was carried out with radiological studies and confirmed by laparotomy. Surgical procedures consisted of duodenal-duodenal anastomosis in two, sphincteroplasty in one, and gastrojejunoanastomosis in the other. Two patients are asymptomatic, one died in the postoperative period, and one was lost for follow up. These four cases represent all the experience of our institute and correspond to one case in 36,735 admissions.

  11. [Septic abortion in the Hospital de Ginecología y Obstetricia no. 3 del Instituto Mexicana de Seguridad Social. Late and early morbidity].

    PubMed

    López Ortiz, E; Sandoval Sevilla, S; Arteaga, V M; Rosas Arceo, J; Ortíz Arroyo, R

    1974-02-01

    268 cases of septic abortion which occurred between 1964-72 in a large metropolitan hospital in Mexico were analyzed retrospecively. There cases represented 0.88% of all cases of abortion during the same time. Most patients were between 21-30, and 48% with parity 2-5; 63% were at their first abortion; only 16 patients declared to have attempted abortion, and most cases were first trimester abortion. Pre- and postoperative procedures and vital signs were carefully taken, and time elapsed from medical treatment to surgery was 4-12 hours. There were 237 curettages, and 28 hysterectomies. Complication from surgery were 4.1%; there were 19 deaths, i.e. 7.5% of patients, of which 10 only 24 hours after hospitalization. Protocol of treatment of septic abortion is discussed, and surgical treatment highly recommended.

  12. A Brazilian in the Reich of Wilhelm II: Henrique da Rocha Lima, Brazil-Germany relations and the Instituto Oswaldo Cruz, 1901-1909.

    PubMed

    Silva, André Felipe Cândido da

    2013-03-01

    This article follows the career of the Brazilian physician Henrique da Rocha Lima, one of the first to join the group of young researchers working at the Instituto Soroterápico de Manguinhos (Instituto Oswaldo Cruz). It describes his first voyage to Germany where he specialized in microbiology and pathological anatomy, training that shaped his subsequent professional identity. The tensions and dilemmas experienced by Rocha Lima provide an insight into what it meant to dedicate oneself to a scientific career in Brazil at the start of the twentieth century. They also reveal the importance of the relations with the German-speaking world for the experimental medicine that became established under the leadership of Oswaldo Cruz.

  13. [Strategic planning models at the Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán].

    PubMed

    Velázquez-Pastrana, Ruth

    2013-01-01

    The Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (Spanish acronym INCMNSZ) is a third tier healthcare facility operated by the Mexican Ministry of Health, ando ver the years various strategic planning models have been used in its development. This paper present a brief overview of some of those strategic planning models and their application and concludes with a discussion of the lessons learned and challenges than remain.

  14. [Occupational health in the Autonomous Community of the Basque Country. OSALAN-Instituto Vasco de Seguridad y Salud Laborales].

    PubMed

    Martínez Castillo, A; Achutegui Basagoiti, G

    1996-01-01

    O.S.A.L.A.N.-Instituto Vasco de Seguridad y Salud Laborales is an autonomous administrative body depending on the Basque Government, ascribed to the Dept. of Justice, Economy, Work and Social Security, which is in charge of managing the general occupational health policies in the Autonomous Community of the Basque Country. Its objectives are: To promote an ongoing improvement in safety and occupational health for all the workers in the Basque Autonomous Region, through the management of programmes in matters affecting safety, hygiene, the environment and occupational health. To co-ordinate and concentrate the different activities related to occupational health, unifying and giving coherence to the functions which were previously the jurisdiction of different departments. Making companies aware of national and E.U. regulations, taking the measures that are set out by the European Directives and the Prevention of Occupational Hazards Act and the rest of the employment regulations, establishing the training and information channels required for promoting and applying these in the companies. It acts: from an overall perspective as regards the prevention of occupational hazards, thanks to co-ordination with all the disciplines involved, applying a multi-disciplinary treatment to the study of each and every one of the occupational hazard factors, which is aimed at the prevention of risks at their source. Providing companies with the ideal means for managing the safety and health of their workers. Promoting the implementation of systems which guarantee an ongoing improvement in occupational safety and health in the companies of the Basque Autonomous Region. Providing the technical and research support that makes it possible to tackle prevention efficiently. The provision established in the Creation Act (O.S.A.L.A.N.) should also be mentioned, as regards its application in public administration and the field of social economy, which was later endorsed and ratified through

  15. [Superficial mycoses: casuistry of the Mycology Department of the Instituto Nacional de Higiene "Rafael Rangel", Caracas, Venezuela (2001-2014)].

    PubMed

    Capote, Ana María; Ferrara, Giuseppe; Panizo, María Mercedes; García, Nataly; Alarcón, Víctor; Reviakina, Vera; Dolande, Maribel

    2016-03-01

    The superficial mycoses are very common infectious diseases and therefore are a frequent reason for medical consultation. The aim of this study was to determine the diagnostic frequency of superficial mycoses in the Mycology Department of the Instituto Nacional de Higiene "Rafael Rangel" during 14 years (2001-2014). A retrospective cross-sectional study was performed to review the mycological records of patients with presumptive diagnosis of superficial mycosis. Nails, hairs and epidermal scales were the processed samples. The identification of fungi was performed by macro and microscopic observation of colonies and biochemical and physiological tests, as required of the isolated agent. For the investigation of Malassezia spp. only direct examination was performed. Of the 3 228 samples processed, 1 098 (34%) were positive and their distribution according to the etiological agent was: dermatophytes 79.5%; 10.9% yeasts; non-dermatophytes fungi 5.1% and 4.5% Malassezia spp. The most frequently isolated dermatophyte was Trichophyton rubrum Complex (70.1%), followed by T mentagrophytes complex (15.1%), Microsporum canis (9.4%) and Epidermophyton floccosum (4%). The most frequent ringworms Were: Tinea unguium (66.8%), followed by Tineapedis (16.4%) and Tinea capitis (8.1%). Candida parapsilosis complex (37.5%) was the most frequently isolated yeast and Fusarium spp. (53.6%) was the most isolated among non-dermatophyte fungi, followed by Aspergillus spp. (19.6%) and Acremonium spp. (10.7%). The identification of the etiological agent is essential to guide appropriate treatment. This study constitutes an important contribution to the knowledge of the epidemiology of superficial mycoses in our country. PMID:27382801

  16. [Occupational health in the Autonomous Community of the Basque Country. OSALAN-Instituto Vasco de Seguridad y Salud Laborales].

    PubMed

    Martínez Castillo, A; Achutegui Basagoiti, G

    1996-01-01

    O.S.A.L.A.N.-Instituto Vasco de Seguridad y Salud Laborales is an autonomous administrative body depending on the Basque Government, ascribed to the Dept. of Justice, Economy, Work and Social Security, which is in charge of managing the general occupational health policies in the Autonomous Community of the Basque Country. Its objectives are: To promote an ongoing improvement in safety and occupational health for all the workers in the Basque Autonomous Region, through the management of programmes in matters affecting safety, hygiene, the environment and occupational health. To co-ordinate and concentrate the different activities related to occupational health, unifying and giving coherence to the functions which were previously the jurisdiction of different departments. Making companies aware of national and E.U. regulations, taking the measures that are set out by the European Directives and the Prevention of Occupational Hazards Act and the rest of the employment regulations, establishing the training and information channels required for promoting and applying these in the companies. It acts: from an overall perspective as regards the prevention of occupational hazards, thanks to co-ordination with all the disciplines involved, applying a multi-disciplinary treatment to the study of each and every one of the occupational hazard factors, which is aimed at the prevention of risks at their source. Providing companies with the ideal means for managing the safety and health of their workers. Promoting the implementation of systems which guarantee an ongoing improvement in occupational safety and health in the companies of the Basque Autonomous Region. Providing the technical and research support that makes it possible to tackle prevention efficiently. The provision established in the Creation Act (O.S.A.L.A.N.) should also be mentioned, as regards its application in public administration and the field of social economy, which was later endorsed and ratified through

  17. [Bibliometric analysis of Revista Médica del IMSS in the Scopus database for the period between 2005-2013].

    PubMed

    García-Gómez, Francisco; Ramírez-Méndez, Fernando

    2015-01-01

    Objetivo: analizar la visibilidad de la Revista Médica del Instituto Mexicano del Seguro Social (Rev Med Inst Mex Seguro Soc) en la base de datos Scopus y describir los principales indicadores bibliométricos cuantitativos de la producción científica publicados durante el periodo 2005-2013. Métodos: para el análisis se utilizó la base de datos Scopus y se limitó el periodo de búsqueda a los años 2005-2013. La estrategia de búsqueda se ejecutó en los campos específicos de Título de la Publicación (Source Title) con el término Revista Médica del Instituto Mexicano del Seguro Social y sus posibles variantes, asícomo el número ISSN de la revista. Para el análisis de los datos obtenidos se utilizaron las herramientas de Scopus y los programas Excel y Access. Resultados: se encontraron 864 trabajos publicados durante el periodo 2005-2013 que fueron incluidos en Scopus. Se identificaron los autores con mayor producción científica y mayor número de citas acumuladas a sus trabajos, asícomo las principales revistas que citan a la Rev Med Inst Mex Seguro Soc. Se describen las principales áreas temáticas, tipos de documentos y otros indicadores bibliométricos que caracterizan a la publicación. Conclusiones: el uso de Scopus brinda la posibilidad de analizar con una herramienta externa al IMSS la visibilidad de la producción científica publicada en la Revista Médica del IMSS, además de que contribuye a identificar el estado de la ciencia en México y de los países en vías desarrollo.

  18. [Organization of medical specialization in cervical cancer and its control in Brazil: the Instituto de Ginecologia in Rio de Janeiro in the mid-twentieth century].

    PubMed

    Lana, Vanessa

    2016-01-01

    Instituto de Ginecologia (Institute of Gynecology), in Rio de Janeiro, headed by Dr. Arnaldo de Moraes, was the first institution in Brazil to introduce and divulge medical techniques for the control of cervical cancer in the mid-1900s. It became a benchmark for actions geared towards the disease at the time, organizing a specific diagnostic procedure that set Brazilian medicine apart in the field, in which it remained a leader until the 1970s. The aim of this text is to discuss the organization and running of the institution from two perspectives: its role in enhancing the position of gynecology as a medical specialty, and its role in spreading a standard practice for the control of cervical cancer. PMID:27438733

  19. [Institutional renovation and scientific modernization: the creation of the Instituto de Investigaciones Hematológicas during the mid-1950s].

    PubMed

    Buschini, José

    2013-12-01

    Using documentary sources, this work analyzes the creation and initial functioning of the Instituto de Investigaciones Hematológicas (Institute of Hematological Research) of the National Academy of Medicine (Buenos Aires, Argentina) in the context of the scientific modernization initiated within the country during the mid-1950s. Particular attention is paid to the generation of material bases and institutional and cultural mechanisms for the development of scientific research and of clinical practices guided by procedures and techniques rooted in the basic sciences. The formation and development of a research school in the Experimental Leukemia Section of the institute is explored as a case illustrative of the effective consolidation of initiatives oriented towards the organization of a scientific center.

  20. [Organization of medical specialization in cervical cancer and its control in Brazil: the Instituto de Ginecologia in Rio de Janeiro in the mid-twentieth century].

    PubMed

    Lana, Vanessa

    2016-01-01

    Instituto de Ginecologia (Institute of Gynecology), in Rio de Janeiro, headed by Dr. Arnaldo de Moraes, was the first institution in Brazil to introduce and divulge medical techniques for the control of cervical cancer in the mid-1900s. It became a benchmark for actions geared towards the disease at the time, organizing a specific diagnostic procedure that set Brazilian medicine apart in the field, in which it remained a leader until the 1970s. The aim of this text is to discuss the organization and running of the institution from two perspectives: its role in enhancing the position of gynecology as a medical specialty, and its role in spreading a standard practice for the control of cervical cancer.

  1. Viability and molecular authentication of Coccidioides spp. isolates from the Instituto de Medicina Tropical de São Paulo culture collection, Brazil.

    PubMed

    Cavalcanti, Sarah Desirée Barbosa; Vidal, Mônica Scarpelli Martinelli; Sousa, Maria da Glória Teixeira de; Del Negro, Gilda Maria Barbaro

    2013-01-01

    Coccidioidomycosis is an emerging fungal disease in Brazil; adequate maintenance and authentication of Coccidioides isolates are essential for research into genetic diversity of the environmental organisms, as well as for understanding the human disease. Seventeen Coccidioides isolates maintained under mineral oil since 1975 in the Instituto de Medicina Tropical de São Paulo (IMTSP) culture collection, Brazil, were evaluated with respect to their viability, morphological characteristics and genetic features in order to authenticate these fungal cultures. Only five isolates were viable after almost 30 years, showing typical morphological characteristics, and sequencing analysis using Coi-F and Coi-R primers revealed 99% identity with Coccidioides genera. These five isolates were then preserved in liquid nitrogen and sterile water, and remained viable after two years of storage under these conditions, maintaining the same features.

  2. [Researchers training in the context of the collaborative projects: experiences of Instituto de Medicina Tropical "Alexander von Humbolt", Universidad Peruana Cayetano Heredia].

    PubMed

    Gotuzzo, Eduardo; González, Elsa; Verdonck, Kristien

    2010-09-01

    Research is a main element for human and social development. Under this point of view, it involves particular challenges and opportunities for the so-called "developing countries". An approach for those challenges and opportunities comes from the analysis of two interrelated activities; the training of new researchers and the research development with institutions or researchers which are external to the institution ("collaborative research"). Both activities are essential for the consolidation, widening and updating of the institutional capabilities for scientific production. We present here the experiences of the Instituto de Medicina Tropical "Alexander von Humboldt" of the Universidad Peruana Cayetano Heredia, in relation to the training of new researchers, we discuss the four elements we consider key for this process; the promotion of stimulating environments for research, the proactive identification of fellows, the complementary advice and networks consolidation; and we analyze three successful models of international collaboration for the training of new researchers under different institutional approaches.

  3. Catalog of type specimens of invertebrates in the collection of the Instituto Nacional de Pesquisas da Amazônia, Manaus, Brazil. VI. Hexapoda: Hemiptera: Heteroptera.

    PubMed

    Rodrigues, Higor D D; Ferreira-Keppler, Ruth L

    2013-01-01

    A catalog of type specimens of Heteroptera (Insecta: Hemiptera) deposited in the Instituto Nacional de Pesquisas da Amazônia (INPA), Manaus, Brazil, is presented and updated to May, 2012. A total of 37 holotypes and 61 lots of paratypes of 78 species are listed in their families: Miridae and Reduviidae (infraorder: Cimicomorpha); Mesoveliidae and Velfidae (Gerromorpha); Belostomatidae, Naucoridae, and Notonectidae (Nepomorpha); and Coreidae, Geocoridae [the older sense of "Lygaeidae"], and Pentatomidae (Pentatomomorpha). The taxa are presented alphabetically by infraorders, families, and genera, followed by epithet, bibliographic citation, type category, collection number, method of preservation, and present data on the labels. When necessary, we added localities data, and changes in taxonomic status of some species

  4. Informe a la nación indica que los índices de muertes por cáncer siguen bajando

    Cancer.gov

    Los índices de mortalidad por todos los cánceres combinados para hombres, mujeres y niños siguieron bajando en Estados Unidos entre 2004 y 2008, según el Informe Anual a la Nación sobre el Estado del Cáncer de 1975 a 2008. El índice general de diagnóstico

  5. Preguntas y respuestas acerca del Estudio del

    Cancer.gov

    El Estudio del Tamoxifeno y Raloxifeno (STAR, por sus siglas en ingls) es un estudio clnico (un estudio de investigacin conducido con voluntarios) diseado para ver cómo el medicamento raloxifeno (Evista) se compara con el medicamento tamoxifeno (Nolvadex)

  6. The collection and database of Birds of Angola hosted at IICT (Instituto de Investigação Científica Tropical), Lisboa, Portugal

    PubMed Central

    Monteiro, Miguel; Reino, Luís; Beja, Pedro; Mills, Michael Stuart Lyne; Bastos-Silveira, Cristiane; Ramos, Manuela; Rodrigues, Diana; Neves, Isabel Queirós; Consciência, Susana; Figueira, Rui

    2014-01-01

    Abstract The bird collection of the Instituto de Investigação Cientítica Tropical (Lisbon, Portugal) holds 5598 preserved specimens (skins), mainly from Angola, Mozambique, Guinea-Bissau, São Tomé and Principe, and Cape Verde. The subset collection from Angola includes 1560 specimens, which were taxonomically revised and georeferenced for the publication of this data paper. The collection contains a total of 522 taxa, including 161 species and 361 subspecies. Two species are classified by the IUCN Red List as Endangered - the wattled crane (Grus carunculata) and the Gabela bush-shrike (Laniarius amboimensis) - and two are classified as vulnerable - African penguin (Spheniscus demersus) and the white-headed vulture (Trigonoceps occipitalis). The temporal span of the database ranges between 1943 and 1979, but 32% are from years 1958–1959, and 25% from years 1968–1969. The spatial coverage of the collection is uneven, with 2/3 of the records representing only four of the eighteen provinces of the country, namely Huíla, Moxico, Namibe and Cuanza Sul. It adds, however, valuable information for the Huíla area of the Angolan Scarp, which is probably a biodiversity hotspot of global conservation priority. Furthermore, this georeferenced database adds invaluable bird information to the GBIF network, for one of the countries with highest but less known biodiversity in Africa. PMID:24693221

  7. The collection and database of Birds of Angola hosted at IICT (Instituto de Investigação Científica Tropical), Lisboa, Portugal.

    PubMed

    Monteiro, Miguel; Reino, Luís; Beja, Pedro; Mills, Michael Stuart Lyne; Bastos-Silveira, Cristiane; Ramos, Manuela; Rodrigues, Diana; Neves, Isabel Queirós; Consciência, Susana; Figueira, Rui

    2014-01-01

    The bird collection of the Instituto de Investigação Cientítica Tropical (Lisbon, Portugal) holds 5598 preserved specimens (skins), mainly from Angola, Mozambique, Guinea-Bissau, São Tomé and Principe, and Cape Verde. The subset collection from Angola includes 1560 specimens, which were taxonomically revised and georeferenced for the publication of this data paper. The collection contains a total of 522 taxa, including 161 species and 361 subspecies. Two species are classified by the IUCN Red List as Endangered - the wattled crane (Grus carunculata) and the Gabela bush-shrike (Laniarius amboimensis) - and two are classified as vulnerable - African penguin (Spheniscus demersus) and the white-headed vulture (Trigonoceps occipitalis). The temporal span of the database ranges between 1943 and 1979, but 32% are from years 1958-1959, and 25% from years 1968-1969. The spatial coverage of the collection is uneven, with 2/3 of the records representing only four of the eighteen provinces of the country, namely Huíla, Moxico, Namibe and Cuanza Sul. It adds, however, valuable information for the Huíla area of the Angolan Scarp, which is probably a biodiversity hotspot of global conservation priority. Furthermore, this georeferenced database adds invaluable bird information to the GBIF network, for one of the countries with highest but less known biodiversity in Africa.

  8. [Strategy to strengthen health research capabilities in regional public universities: the role of the Mining Canon and the Instituto Nacional de Salud].

    PubMed

    Romaní, Franco; Cabezas, César; Espinoza, Manuel; Minaya, Gabriela; Huaripata, José; Ureta, Juan Manuel; Yazuda, Myriam; Gastañaga, María del Carmen; Miraval, María Luz; Aparco, Juan Pablo; Anaya, Elizabeth; Castro, José; Esquivel, Silvia

    2012-01-01

    The development of scientific health research requires a sustained and articulated research system that is consistent with the research priorities, as well as both internal and external funding, and availability of competent human resources. The Mining Canon, a constitutional right, has been partly used to foster applied scientific research in public universities (PU). In addition, the National Health Institute (INSTITUTO NACIONAL DE SALUD - INS) is devoted, among others, to promoting, managing and disseminating health research development at a national level. As part of these activities, a technical team was created to provide technical assistance to PU for research development using Mining Canon funds by making local adjustments to research protocols promoted by the INS and assumed by the professors-researchers at the Universities. This article aims at describing the reality of research at Peruvian public universities that have access to Mining Canon funds, as well as to elaborate on the work the INS is carrying out in order to strengthen research capabilities, starting with the development of research proposals that could potentially be funded by the Mining Canon.

  9. [Strategy to strengthen health research capabilities in regional public universities: the role of the Mining Canon and the Instituto Nacional de Salud].

    PubMed

    Romaní, Franco; Cabezas, César; Espinoza, Manuel; Minaya, Gabriela; Huaripata, José; Ureta, Juan Manuel; Yazuda, Myriam; Gastañaga, María del Carmen; Miraval, María Luz; Aparco, Juan Pablo; Anaya, Elizabeth; Castro, José; Esquivel, Silvia

    2012-01-01

    The development of scientific health research requires a sustained and articulated research system that is consistent with the research priorities, as well as both internal and external funding, and availability of competent human resources. The Mining Canon, a constitutional right, has been partly used to foster applied scientific research in public universities (PU). In addition, the National Health Institute (INSTITUTO NACIONAL DE SALUD - INS) is devoted, among others, to promoting, managing and disseminating health research development at a national level. As part of these activities, a technical team was created to provide technical assistance to PU for research development using Mining Canon funds by making local adjustments to research protocols promoted by the INS and assumed by the professors-researchers at the Universities. This article aims at describing the reality of research at Peruvian public universities that have access to Mining Canon funds, as well as to elaborate on the work the INS is carrying out in order to strengthen research capabilities, starting with the development of research proposals that could potentially be funded by the Mining Canon. PMID:23338644

  10. [The Bernardino Álvarez Farm Hospital and Farm School: antecedents to Instituto Nacional de Neurología y Neurocirugía].

    PubMed

    Rodríguez-de Romo, Ana Cecilia; Castañeda-López, Gabriela

    2013-01-01

    By 1960, México's Manicomio General (General Asylum) could no longer fulfill the functions for which it was created so implementation of the so-called Castañeda Operation began, an initiative designed to close down and relocate psychiatric patients to other institutions. At that time, Dr. Manuel Velasco-Suárez was in charge of the General Direction of Neurology, Mental Health and Rehabilitation, and planned to create the Institute of Neurology on a site he already possessed for its construction. The Asylum was a dependency of the aforementioned Direction and Velasco- Suárez decided that some patients at the Castañeda could be moved to the old hacienda house that stood on that terrain. Thus was born the Bernardino Álvarez Farm Hospital. A year later, in 1961, the Farm School for the Weak-Minded, also named Bernardino Álvarez was established there as well. This paper examines the history of these two institutions as antecedents to the Instituto Nacional de Neurología y Neurocirugía.

  11. Epidemiology of central nervous system tumors at the Instituto Nacional de Neurología y Neurocirugía in Mexico City.

    PubMed

    Velásquez-Pérez, L; Jiménez-Marcial, M E; Martínez-Martínez, J E

    2004-10-01

    The purpose of this study was to determine the frequency of different Central Nervous System Tumors (CNST) diagnosed at the Instituto Nacional de Neurología y Neurocirugía (National Institute of Neurology and Neurosurgery) from Mexico City over a 10-year period (1990 to 1999) by means of a hospital survey. This institute is a reference hospital that provides medical attention to a very high number of adult neurological patients every year (approximately 6,000 new patients per year besides emergency cases). From a total number of 2,041 CNST cases, we found that the most frequent tumors were those affecting the neuroepithelial tissue (32.8 %), followed by tumors of the anterior pituitary gland (26.2 %) and tumors of the meninges and similar tissues (24.1 %). In both, male and female patients the higher frequency of CNST was found in patients whose age ranged from 25 to 44 years, and CNST were slightly more frequent in women than in men. Most of the CNST patients lived in the southern districts of Mexico City, it could be because of the great number of people living in the southern districts of the city, or perhaps due to the presence of certain yet unidentified environmental carcinogenic substance in this area. Since CNST are among the more frequent malignant neoplasms, it is necessary to improve the registration system to include frequency, prevalence, incidence and mortality of these diseases in Mexico, in order to plan health policies like in developed countries.

  12. The collection and database of Birds of Angola hosted at IICT (Instituto de Investigação Científica Tropical), Lisboa, Portugal.

    PubMed

    Monteiro, Miguel; Reino, Luís; Beja, Pedro; Mills, Michael Stuart Lyne; Bastos-Silveira, Cristiane; Ramos, Manuela; Rodrigues, Diana; Neves, Isabel Queirós; Consciência, Susana; Figueira, Rui

    2014-01-01

    The bird collection of the Instituto de Investigação Cientítica Tropical (Lisbon, Portugal) holds 5598 preserved specimens (skins), mainly from Angola, Mozambique, Guinea-Bissau, São Tomé and Principe, and Cape Verde. The subset collection from Angola includes 1560 specimens, which were taxonomically revised and georeferenced for the publication of this data paper. The collection contains a total of 522 taxa, including 161 species and 361 subspecies. Two species are classified by the IUCN Red List as Endangered - the wattled crane (Grus carunculata) and the Gabela bush-shrike (Laniarius amboimensis) - and two are classified as vulnerable - African penguin (Spheniscus demersus) and the white-headed vulture (Trigonoceps occipitalis). The temporal span of the database ranges between 1943 and 1979, but 32% are from years 1958-1959, and 25% from years 1968-1969. The spatial coverage of the collection is uneven, with 2/3 of the records representing only four of the eighteen provinces of the country, namely Huíla, Moxico, Namibe and Cuanza Sul. It adds, however, valuable information for the Huíla area of the Angolan Scarp, which is probably a biodiversity hotspot of global conservation priority. Furthermore, this georeferenced database adds invaluable bird information to the GBIF network, for one of the countries with highest but less known biodiversity in Africa. PMID:24693221

  13. [Clinico-pathological diagnostic agreement among 429 autopsies from the Instituto Nacional de la Nutrición Salvador Zubirán].

    PubMed

    Angeles-Angeles, A; Quintanilla Martínez, L; Muñoz Fernández, L; Espinoza Vázquez, B; Victoría Peralta, P

    1992-01-01

    Comparison of clinical and autopsy findings of the cases studied between 1984 and 1988, were made at the Department of Pathology of the Instituto Nacional de la Nutricion Salvador Zubiran in Mexico City. The goal was to determine the accuracy of clinical diagnoses. The total number of cases was 429. A decreasing number of autopsies as a function of time was observed. Thus, in 1985, 34.65% of the deaths was autopsied, whereas in 1988, the number dropped to 21.16%, overall mean of 27.31%. In 229 autopsies (53.8%), 353 findings of clinical significance were found; of these, 86 were in the main diagnoses and 267 in the causes of death. There were 171 overdiagnoses with therapeutic implications, 38 in the main diagnoses and 133 in the causes of death. Overdiagnoses and underdiagnoses were most common in infectious diseases, followed by respiratory and digestive diseases, while endocrinologic and rheumatologic diseases had the highest diagnostic concordance. It was also found that the diagnostic accuracy did not improve with time of hospitalization. A brief analyses of the probable causes of the decrease in the number of autopsies is made. It is concluded that, in spite of the great advances in clinical and technological knowledge, the high frequency of disagreements between clinical and anatomical diagnoses, indicate that autopsy continues playing a key role in the quality control of medical practice. This justifies by itself the performance of necropsies.

  14. [What patients think of the services of the Instituto Nacional de la Nutrición "Salvador Zubirán"].

    PubMed

    Ruiz-González, C; Vargas-Vorácková, F; Castillo-Rentería, C; Pérez Pimentel, L; Martínez Mata, R A

    1990-01-01

    The quality of care has always been a subject of interest to the Instituto Nacional de la Nutrición "Salvador Zubirán", in order to improve its services. This interest led to the present survey which aims to evaluate the patient's global satisfaction and to identify specific problems susceptible of improvement. One hundred and seventy-one patients or relatives attending eight different services of the Institute were interviewed. Opinions about the following aspects were explored by means of service-specific questionnaires: sociodemographic characteristics, satisfaction with care, waiting periods, patient-personnel relationship, hospital environment, food quality, drug availability and costs. Results of the survey show a high level of satisfaction with the services provided, i.e. 33% of the patients considered it good, and 64% excellent. However, and in agreement with other reports, this high level of satisfaction does not necessarily reflect an absence of problems, i.e. long waiting periods, insufficient restrooms, failures in getting information about their health status, and occasional absence of drugs in the pharmacy were identified. Continuation of this kind of surveys in our setting leads not only to the identification of problems, but also to the evaluation of the impact that resulting measures may have on the patient's satisfaction.

  15. Instituto Geografico Nacional of Spain

    NASA Technical Reports Server (NTRS)

    Colomer, Francisco; Garcia-Espada, Susana; Gomez-Gonzalez, Jesus; Lopez-Fernandez, Jose Antonio; Santamaria-Gomez, Alvaro; De Vicente, Pablo

    2013-01-01

    This report updates the description of the space geodesy facilities of the Spanish National Geographic Institute (IGN). The current 40-meter radio telescope at Yebes, a network station for IVS, has performed geodetic VLBI observations regularly since September 2008. In addition to this, the project to establish an Atlantic Network of Geodynamical and Space Stations (RAEGE) is progressing with the construction of the first antenna, which is being erected at Yebes.

  16. Mineralogy and instrumental neutron activation analysis of seven National Bureau of Standards and three Instituto de Pesquisas Tecnologicas clay reference samples

    USGS Publications Warehouse

    Hosterman, John W.; Flanagan, F.J.; Bragg, Anne; Doughten, M.W.; Filby, R.H.; Grimm, Catherine; Mee, J.S.; Potts, P.J.; Rogers, N.W.

    1987-01-01

    The concentrations of 3 oxides and 29 elements in 7 National Bureau of Standards (NBS) and 3 Instituto de Pesquisas Techno16gicas (IPT) reference clay samples were etermined by instrumental neutron activation analysis. The analytical work was designed to test the homogeneity of constituents in three new NBS reference clays, NBS-97b, NBS-98b, and NBS-679. The analyses of variance of 276 sets of data for these three standards show that the constituents are distributed homogeneously among bottles of samples for 94 percent of the sets of data. Three of the reference samples (NBS-97, NBS-97a, and NBS-97b) are flint clays; four of the samples (NBS-98, NBS-98a, NBS-98b, and IPT-32) are plastic clays, and three of the samples (NBS-679, IPT-28, and IPT-42) are miscellaneous clays (both sedimentary and residual). Seven clays are predominantly kaolinite; the other three clays contain illite and kaolinite in the approximate ratio 3:2. Seven clays contain quartz as the major nonclay mineral. The mineralogy of the flint and plastic clays from Missouri (NBS-97a and NBS-98a) differs markedly from that of the flint and plastic clays from Pennsylvania (NBS-97, NBS-97b, NBS-98, and NBS-98b). The flint clay NBS-97 has higher average chromium, hafnium, lithium, and zirconium contents than its replacement, reference sample NBS-97b. The differences between the plastic clay NBS-98 and its replacement, NBS-98b, are not as pronounced. The trace element contents of the flint and plastic clays from Missouri, NBS-97a and NBS-98a, differ significantly from those of the clays from Pennsylvania, especially the average rare earth element (REE) contents. The trace element contents of clay sample IPT-32 differ from those of the other plastic clays. IPT-28 and IPT-42 have some average trace element contents that differ not only between these two samples but also from all the other clays. IPT-28 has the highest summation of the average REE contents of the 10 samples. The uranium content of NBS-98a, 46

  17. Estudio del CH interestelar

    NASA Astrophysics Data System (ADS)

    Olano, C.; Lemarchand, G.; Sanz, A. J.; Bava, J. A.

    El objetivo principal de este proyecto consiste en el estudio de la distribución y abundancia del CH en nubes interestelares a través de la observación de las líneas hiperfinas del CH en 3,3 GHz. El CH es una molécula de amplia distribución en el espacio interestelar y una de las pocas especies que han sido observadas tanto con técnicas de radio como ópticas. Desde el punto de vista tecnológico se ha desarrollado un cabezal de receptor que permitirá la realización de observaciones polarimétricas en la frecuencia de 3,3 GHz, con una temperatura del sistema de 60 K y un ancho de banda de 140 MHz, y que será instalado en el foco primario de la antena parabólica del IAR. El cabezal del receptor es capaz de detectar señales polarizadas, separando las componentes de polarización circular derecha e izquierda. Para tal fin el cabezal consta de dos ramas receptoras que amplificarán la señal y la trasladarán a una frecuencia más baja (frecuencia intermedia), permitiendo de esa forma un mejor transporte de la señal a la sala de control para su posterior procesamiento. El receptor además de tener características polarimétricas, podrá ser usado en el continuo y en la línea, utilizando las ventajas observacionales y de procesamiento de señal que actualmente posee el IAR.

  18. The Del Rio ataxite, Texas

    NASA Technical Reports Server (NTRS)

    Henderson, E. P.; King, E. A.

    1977-01-01

    Basic data are presented on the Del Rio, Nordheim, and Monahans ataxites found in Texas. Results are reported for bulk-chemistry analysis, metallographic observations, and electron-microprobe analysis of the Del Rio meteorite. It is shown that Del Rio is distinctly different from the other two ataxites in terms of nickel, phosphorous, and carbon content, and is composed of at least three coarse grains in different crystallographic orientations. All the kamacite in Del Rio is found to have transformation structures that are probable shock products, and minor inclusions of daubreelite, schreibersite, and troilite are observed. It is concluded that Del Rio was apparently mildly shocked prior to its fall.

  19. Vistazos Intimos De Puebla; Una Compilacion De Informes Individuales Preparados Por Los Participantes Del Instituto De Verano (NDEA) (Close-ups on Puebla; A Compilation of Individual Reports Prepared by the Participants of the NDEA Summer Institute).

    ERIC Educational Resources Information Center

    Wichita State Univ., KS.

    The individual and committee reports on the sociology of Puebla, Mexico, which are collected here, were written by participants in an NDEA Summer Institute program of the University of Wichita, Kansas. The underlying motives of the program, described in the preface, were to provide participants with real language experience and a chance to…

  20. [Scientific charity: Moncorvo Filho and the Instituto de Proteção e Assistência à Infância of Rio de Janeiro (1899-1930)].

    PubMed

    Freire, Maria Martha de Luna; Leony, Vinícius da Silva

    2011-12-01

    The article follows the trajectory of Doctor Arthur Moncorvo Filho and the Instituto de Proteção e Assistência à Infância, an organization that he founded in Rio de Janeiro in 1899. It examines them within the context of the construction of Brazil's institutional network in the field of children's health assistance in the first half of the twentieth century, a process that combined philanthropic activities, scientific practices, and public investments. This philanthropic physician played a model role, as he conjoined assistance activities with the application of innovative medical techniques and proposed or called for public policies that targeted motherhood and children.

  1. Nevado del Huila, Columbia

    NASA Technical Reports Server (NTRS)

    2007-01-01

    Nevado del Huila Volcano in Colombia is actually a volcanic chain running north to south, capped by a glacier. With peaks ranging in height from 2,600 to 5,780 meters (8,530 to 18,960 feet), Nevado del Huila is a stratovolcano composed of alternating layers of hardened lava, solidified ash, and volcanic rocks. Its first recorded eruption occurred in the mid-sixteenth century. The long-dormant volcano erupted again in mid-April 2007. A few months before the eruption, the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) on NASA's Terra satellite captured this image of Nevado del Huila, on February 23, 2007. In this image, the bright white area just east of the central summit is ice. Immediately west of the summit are bare rocks, appearing as blue-gray. West of those rocks, white reappears, but this patch of white results from clouds hovering in the nearby valley. In the east, the colors turn to brown (indicating bare rock) and bright green (indicating vegetation). ASTER photographed Nevado del Huila near the end of a long phase of quietude. On April 17, 2007, local authorities recorded seismic activity associated with rock fracturing on the volcano's central summit, according to the ReliefWeb Website. Activity intensified the following day with an eruption and mudflows, forcing thousands of nearby residents to evacuate. As the Associated Press reported, the eruption caused avalanches and floods that wiped away both houses and bridges. It marked the volcano's first recorded eruption since the Spanish colonized the area five centuries earlier. NASA image created by Jesse Allen, using data provided courtesy of the NASA/GSFC/MITI/ERSDAC/JAROS, and U.S./Japan ASTER Science Team.

  2. Yeast DEL assay detects clastogens.

    PubMed

    Kirpnick, Zhanna; Homiski, Michael; Rubitski, Elizabeth; Repnevskaya, Marina; Howlett, Niall; Aubrecht, Jiri; Schiestl, Robert H

    2005-04-01

    Chromosomal rearrangements, including DNA deletions are involved in carcinogenesis. The deletion (DEL) assay scoring for DNA deletions in the yeast Saccharomyces cerevisiae is able to detect a wide range of carcinogens. Among approximately 60 compounds of known carcinogenic activity, the DEL assay detected 86% correctly whereas the Ames Salmonella assay detected only 30% correctly [R.J. Brennan, R.H. Schiestl, Detecting carcinogens with the yeast DEL assay, Methods Mol. Biol. 262 (2004) 111-124]. Since the DEL assay is highly inducible by DNA double strand breaks, this study examined the utility of the DEL assay for detecting clastogens. Ten model compounds, with varied mechanisms of genotoxicity, were examined for their effect on the frequency of DNA deletions with the DEL assay. The compounds tested were: actinomycin D, camptothecin, methotrexate and 5-fluorodeoxyuridine, which are anticancer agents, noscapine and furosemide are therapeutics, acridine, methyl acrylate and resorcinol are industrial chemicals and diazinon is an insecticide. The in vitro micronucleus assay (IVMN) in CHO cells, a commonly used tool for detection of clastogens, was performed on the same compounds and the results of the two assays were compared. The results of our study show that there is 70% concordance in the presence of metabolic activation (rat liver S9) and 80% concordance in the absence of metabolic activation between the DEL assay and the standard in vitro micronucleus assay. The lack of cytotoxicity observed for four of the ten compounds examined indicates limited diffusion of lipophilic compounds across the yeast cell wall. Thus, the development of a more permeable yeast tester strain is expected to greatly improve concordance of the DEL assay with the IVMN assay. The yeast DEL assay is inexpensive, amenable to automation and requires less expertise to perform than the IVMN. Thus, it has a strong potential as a robust, fast and economical screen for detecting clastogens in

  3. Case Study: del Amo Bioventing

    EPA Science Inventory

    The attached presentation discusses the fundamentals of bioventing in the vadose zone. The basics of bioventing are presented. The experience to date with the del Amo Superfund Site is presented as a case study.

  4. EJERCICIO Y LA DETECCION DEL MAL AGUDO DE MONTAÑA GRAVE

    PubMed Central

    Garófoli, Adrián; Montoya, Paola; Elías, Carlos; Benzo, Roberto

    2012-01-01

    El Mal Agudo de Montaña (MAM) es un conjunto de síntomas inespecíficos padecidos por sujetos que ascienden rápidamente desde baja a alta altura sin adecuada aclimatación. Usualmente es autolimitado, pero las formas graves (edema pulmonar y cerebral) pueden causar la muerte. La hipoxemia exagerada en reposo está relacionada con el desarrollo de MAM pero su valor predictivo es limitado. Dado que el ejercicio en altura se acompaña de mayor hipoxemia y síntomas, postulamos el valor predictivo de un simple test de ejercicio para pronosticar MAM grave. Se estudió el valor predictivo de la saturación de oxígeno en reposo y ejercicio submáximo a 2 700m y 4 300m en 63 sujetos que ascendían al cerro Aconcagua (6 962m). Se consideró desaturación de oxígeno con ejercicio a una disminución >=5% respecto al reposo. Se utilizó la escala de Lake-Louise para establecer la presencia de MAM grave. 6 sujetos presentaron MAM grave (9.5%) y requirieron evacuación. La saturación de oxígeno en reposo a 2 700m no fue significativa para clasificar sujetos que luego desarrollaron MAM grave. Por el contrario, la asociación de desaturación durante el ejercicio a 2 700m más la saturación inapropiada en reposo a 4 300m fue significativa para clasificar a los sujetos que desarrollaron MAM grave con un valor predictivo positivo de 80% y un valor predictivo negativo del 97%. Nuestros resultados son relevantes para el montañismo y sugieren la adición de un simple test de ejercicio en la predicción del MAM grave. PMID:20228017

  5. El libro del Relogio del Palacio de las Horas

    NASA Astrophysics Data System (ADS)

    Morales, J. D.

    2009-08-01

    This paper resume the investigation entitled ``El libro del Relogio del Palacio de las Horas''. That consist in an edition of the original text of the book of the Clock of the Palace of the Hours from the Books of the knowledge of Astronomy of Alfonso X (Manuscript 156, Complutense University). And a description of the astronomical functionality of the Clock of the Palace of the Hours. It includes a geometric description of the positional astronomy on which the operation of the Palace is based.

  6. The collection of birds from São Tomé and Príncipe at the Instituto de Investigação Científica Tropical of the University of Lisbon (Portugal).

    PubMed

    Monteiro, Miguel; Reino, Luís; Melo, Martim; Beja, Pedro; Bastos-Silveira, Cristiane; Ramos, Manuela; Rodrigues, Diana; Neves, Isabel Queirós; Consciência, Susana; Figueira, Rui

    2016-01-01

    The former Instituto de Investigação Científica Tropical-IICT (Lisbon, Portugal), recently integrated into the University of Lisbon, gathers important natural history collections from Portuguese-speaking African countries. In this study, we describe the bird collection from the Democratic Republic of São Tomé and Príncipe, which was fully taxonomically checked and georeferenced. The IICT bird collection contains 5598 specimens, of which 559 are from São Tomé and Príncipe, representing 85 taxa, including 19 endemic species and 13 endemic subspecies of birds. The specimens were collected between 1946 and 1973, although 43% of the records are from 1954 and 45% are from 1970. The geographic distribution of samples covers the whole territory, with a higher number of records from São Tomé than from Príncipe. The districts with highest number of records are Pagué (equivalent to Príncipe Island), and Água Grande and Mé-Zochi on São Tomé. Despite the relatively low number of specimens per taxon, the importance of the collection is considerable due to the high number of endemic and threatened species represented. Furthermore, it adds valuable information to the GBIF network, especially for a country whose two islands are each an Endemic Bird Area and for which substantial gaps in ornithological knowledge remain. PMID:27408605

  7. The collection of birds from São Tomé and Príncipe at the Instituto de Investigação Científica Tropical of the University of Lisbon (Portugal)

    PubMed Central

    Monteiro, Miguel; Reino, Luís; Melo, Martim; Beja, Pedro; Bastos-Silveira, Cristiane; Ramos, Manuela; Rodrigues, Diana; Neves, Isabel Queirós; Consciência, Susana; Figueira, Rui

    2016-01-01

    Abstract The former Instituto de Investigação Científica Tropical-IICT (Lisbon, Portugal), recently integrated into the University of Lisbon, gathers important natural history collections from Portuguese-speaking African countries. In this study, we describe the bird collection from the Democratic Republic of São Tomé and Príncipe, which was fully taxonomically checked and georeferenced. The IICT bird collection contains 5598 specimens, of which 559 are from São Tomé and Príncipe, representing 85 taxa, including 19 endemic species and 13 endemic subspecies of birds. The specimens were collected between 1946 and 1973, although 43% of the records are from 1954 and 45% are from 1970. The geographic distribution of samples covers the whole territory, with a higher number of records from São Tomé than from Príncipe. The districts with highest number of records are Pagué (equivalent to Príncipe Island), and Água Grande and Mé-Zochi on São Tomé. Despite the relatively low number of specimens per taxon, the importance of the collection is considerable due to the high number of endemic and threatened species represented. Furthermore, it adds valuable information to the GBIF network, especially for a country whose two islands are each an Endemic Bird Area and for which substantial gaps in ornithological knowledge remain. PMID:27408605

  8. The collection of birds from São Tomé and Príncipe at the Instituto de Investigação Científica Tropical of the University of Lisbon (Portugal).

    PubMed

    Monteiro, Miguel; Reino, Luís; Melo, Martim; Beja, Pedro; Bastos-Silveira, Cristiane; Ramos, Manuela; Rodrigues, Diana; Neves, Isabel Queirós; Consciência, Susana; Figueira, Rui

    2016-01-01

    The former Instituto de Investigação Científica Tropical-IICT (Lisbon, Portugal), recently integrated into the University of Lisbon, gathers important natural history collections from Portuguese-speaking African countries. In this study, we describe the bird collection from the Democratic Republic of São Tomé and Príncipe, which was fully taxonomically checked and georeferenced. The IICT bird collection contains 5598 specimens, of which 559 are from São Tomé and Príncipe, representing 85 taxa, including 19 endemic species and 13 endemic subspecies of birds. The specimens were collected between 1946 and 1973, although 43% of the records are from 1954 and 45% are from 1970. The geographic distribution of samples covers the whole territory, with a higher number of records from São Tomé than from Príncipe. The districts with highest number of records are Pagué (equivalent to Príncipe Island), and Água Grande and Mé-Zochi on São Tomé. Despite the relatively low number of specimens per taxon, the importance of the collection is considerable due to the high number of endemic and threatened species represented. Furthermore, it adds valuable information to the GBIF network, especially for a country whose two islands are each an Endemic Bird Area and for which substantial gaps in ornithological knowledge remain.

  9. Vacunas contra los virus del papiloma humano

    Cancer.gov

    Una hoja informativa acerca de las vacunas contra los virus del papiloma humano (VPH) para prevenir infecciones con ciertos tipos de VPH, los cuales son la causa principal del cáncer de cuello del útero o cérvix.

  10. 33 CFR 80.1118 - Marina Del Rey, CA.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Marina Del Rey, CA. 80.1118... NAVIGATION RULES COLREGS DEMARCATION LINES Pacific Coast § 80.1118 Marina Del Rey, CA. (a) A line drawn from Marina Del Rey Breakwater South Light 1 to Marina Del Rey Light 4. (b) A line drawn from Marina Del...

  11. 33 CFR 80.1118 - Marina Del Rey, CA.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Marina Del Rey, CA. 80.1118... NAVIGATION RULES COLREGS DEMARCATION LINES Pacific Coast § 80.1118 Marina Del Rey, CA. (a) A line drawn from Marina Del Rey Breakwater South Light 1 to Marina Del Rey Light 4. (b) A line drawn from Marina Del...

  12. 33 CFR 80.1118 - Marina Del Rey, CA.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Marina Del Rey, CA. 80.1118... NAVIGATION RULES COLREGS DEMARCATION LINES Pacific Coast § 80.1118 Marina Del Rey, CA. (a) A line drawn from Marina Del Rey Breakwater South Light 1 to Marina Del Rey Light 4. (b) A line drawn from Marina Del...

  13. 33 CFR 80.1118 - Marina Del Rey, CA.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 1 2014-07-01 2014-07-01 false Marina Del Rey, CA. 80.1118... NAVIGATION RULES COLREGS DEMARCATION LINES Pacific Coast § 80.1118 Marina Del Rey, CA. (a) A line drawn from Marina Del Rey Breakwater South Light 1 to Marina Del Rey Light 4. (b) A line drawn from Marina Del...

  14. Tierra del Fuego, Argentina, South America

    NASA Technical Reports Server (NTRS)

    1991-01-01

    The Mitre Peninsula is the easternmost tip of Tierra del Fuego, Argentina, (54.5S, 65.5W). Early winter snow can be seen on this south tip of the Andes Mountains. These same mountains continue underwater to Antarctica. The Strait of Magellan, separating the South American mainland from Tierra del Fuego is off the scene to the north and west, but the Strait of LeMaire, separating Tierra del Fuego from the Isla de los Estados can be seen.

  15. Instantánea del linfoma

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el linfoma; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

  16. Instantánea del melanoma

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el melanoma; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

  17. Instantánea del sarcoma

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el sarcoma; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

  18. Instantánea del mieloma

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el mieloma; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

  19. Modelo analítico del efecto de PRS sobre satélites GPS

    NASA Astrophysics Data System (ADS)

    Meza, A.; Brunini, C.; Usandivaras, J. C.

    El sistema GPS (Global Position System) es, hoy en día, la herramienta de navegación y posicionamiento más potente y lo será sin duda en la próxima década. Gran parte de su valiosa utilidad se debe a la alta precisión que permite lograr y ésta, a su vez, depende, entre otras causas, de la precisión con que se conocen las órbitas de los satélites. La presión de radiación solar (PRS) fija el límite de la precisión con que pueden calcularse en la actualidad las efemérides satelitarias. El objetivo de este trabajo es proponer una mejor resolución de este fenómeno. El modelo analítico aquí presentado, se basa en el análisis del comportamiento de los residuos de un ajuste por mínimos cuadrados en el que se utiliza el modelo de PRS propuesto por Beutler. El mismo consiste en un modelo determinista del fenómeno con dos parámetros libres. Los resultados obtenidos ponen de manifiesto que, aún después de aplicar dichos parámetros, prevalecen en los residuos efectos semidiurnos en las componentes radial,tangencial y normal. Estos resultados obtenidos se comparan con los de un trabajo desarrollado por el Instituto de Berne (Beutler et al., 1994), en el que se utilizaron como pseudo-observaciones las órbitas precisas del IGS (CODE). El intervalo de integración escogido por este centro fueron las semanas 680 y 681. En resumen se tienen arcos de 14 días para todos los satélites, donde las efemérides precisas de los mismos para los 14 días fueron utilizados como pseudo-observaciones. El modelo de fuerza que empleó dicho centro fue básicamente el tradicional en lo que respecta al modelo de las fuerzas gravitacionales, y para la PRS utilizo el modelo standard de Beutler. Los parámetros de este modelo junto con las 6 condiciones iniciales (posición y velocidad) fueron ajustados por el método general de mínimos cuadrados. Los residuos en la componente radial, tangencial y normal, para los satélites con un buen comportamiento, presentan una

  20. Produccion Gaseosa del Cometa Halley: Erupciones Y Fotodisociacion del Radical OH

    NASA Astrophysics Data System (ADS)

    Silva, A. M.; Mirabel, I. F.

    1990-11-01

    RESUMEN:En este trabajo informamos la detecci6n de 20 erupciones en la li'nea de =18cm (1667MHz) del radical OH en el Cometa Halley.Las observaciones incluyen todos los monitoreos existentes y se extienden desde 120 dias antes del perihelio hasta 90 dias despues.Se detectan bruscos crecimientos en el flujo medido,hasta un factor 1O,seguidos por decaimientos lentos asociados con la fotodisociaci6n del OH. Se obtuvieron valores para el tiempo de vida fotoquimico del OH y del H2O basandose en el modelo desarrollado previamente por Silva(1988). Esos tiempos de vida estan de acuerdo con predicciones teoricas y con las observaciones en el Ultravioleta, y los resultados, los que son fuertemente dependientes de la velocidad heliocentrica del Coineta (variando hasta un factor 6), han sido calculados para varios rangos de velocidad entre +28 y -28 km/seg. Key wo'L :

  1. Gonadal dysgenesis in del (18p) syndrome

    SciTech Connect

    Telvi, L.; Ion, A.; Fouquet, F.

    1995-07-17

    We report on a girl with syndromal gonadal dysgenesis and a de novo del (18p). Genetic factors controlling gonadal development are located not only on the X chromosome, but also on autosomes. The present case suggests that one of these genes is situated on 18p. We conclude that patients with del (18p) syndrome should be evaluated for gonadal dysgenesis. 16 refs., 3 figs.

  2. El Escritor y las Normas del Canon Literario (The Writer and the Norms of the Literary Canon).

    ERIC Educational Resources Information Center

    Policarpo, Alcibiades

    This paper speculates about whether a literary canon exists in contemporary Latin American literature, particularly in the prose genre. The paper points to Carlos Fuentes, Gabriel Garcia Marquez, and Mario Vargas Llosa as the three authors who might form this traditional and liberal canon with their works "La Muerte de Artemio Cruz" (Fuentes),…

  3. Intertextual Sexual Politics: Illness and Desire in Enrique Gomez Carrillo's "Del amor", "del dolor y del vicio" and Aurora Caceres's "La rosa muerta"

    ERIC Educational Resources Information Center

    LaGreca, Nancy

    2012-01-01

    This study explores the intertextuality between Aurora Caceres's "La rosa muerta" (1914) and the novel "Del amor, del dolor y del vicio" (1898) by her ex-husband, Enrique Gomez Carrillo. Caceres strategically mentions Gomez Carrillo's novel in "La rosa muerta" to invite a reading of her work in dialogue with his. Both narratives follow the sexual…

  4. Visiting the Gödel universe.

    PubMed

    Grave, Frank; Buser, Michael

    2008-01-01

    Visualization of general relativity illustrates aspects of Einstein's insights into the curved nature of space and time to the expert as well as the layperson. One of the most interesting models which came up with Einstein's theory was developed by Kurt Gödel in 1949. The Gödel universe is a valid solution of Einstein's field equations, making it a possible physical description of our universe. It offers remarkable features like the existence of an optical horizon beyond which time travel is possible. Although we know that our universe is not a Gödel universe, it is interesting to visualize physical aspects of a world model resulting from a theory which is highly confirmed in scientific history. Standard techniques to adopt an egocentric point of view in a relativistic world model have shortcomings with respect to the time needed to render an image as well as difficulties in applying a direct illumination model. In this paper we want to face both issues to reduce the gap between common visualization standards and relativistic visualization. We will introduce two techniques to speed up recalculation of images by means of preprocessing and lookup tables and to increase image quality through a special optimization applicable to the Gödel universe. The first technique allows the physicist to understand the different effects of general relativity faster and better by generating images from existing datasets interactively. By using the intrinsic symmetries of Gödel's spacetime which are expressed by the Killing vector field, we are able to reduce the necessary calculations to simple cases using the second technique. This even makes it feasible to account for a direct illumination model during the rendering process. Although the presented methods are applied to Gödel's universe, they can also be extended to other manifolds, for example light propagation in moving dielectric media. Therefore, other areas of research can benefit from these generic improvements. PMID

  5. Calidad de Imagen del Telescopio UNAM212

    NASA Astrophysics Data System (ADS)

    Cobos, F. J.; Teiada de Vargas, C.

    1987-05-01

    El telescopio UNAM2l2, del Observatorio Astronómico Nacional, situado en la Sierra de San Pedro Mártir (Baja California, México), cumplira en un futuro muy cercano siete años de uso para fines de investigación astronómica. Aunque en este tiempo no se ha efectuado un estudio sistemático acerca de su comportamiento óptico y de los factores que influyen en la calidad de las imágenes, se han realizado pruebas diversas, estudios parciales y reuniones especificas, cuyos resultados no siempre se han difundido ampliamente y generalmente no se han presentado por escrito. Es por ello que hemos creido necesario intentar una recopilación de la información existente para poder con ella establecer un diagnóstjco que, aunque no sea definitivo, sirva de base para futuros trabajos tendientes a optimizar el comportamiento óptico del telescopio. Es evidente que un buen número de las conclusiones que se presentan son resultado del trabajo de muchas personas ó de esfuerzos colectivos. Asimismo, hemos tratado de localizar información bibliográfica que pueda ser de utilidad. Nuestro objetivo primordial ha consistido en centrarnos en la óptica del telescopio y su calidad, pero también se han considerado otros aspectos que puedan afectar las imágenes obtenidas tales como: celda del primario, `seeing' local y externo, flexiones posibles en la estructura mecánica del telescopio, etc.

  6. Visiting the Gödel universe.

    PubMed

    Grave, Frank; Buser, Michael

    2008-01-01

    Visualization of general relativity illustrates aspects of Einstein's insights into the curved nature of space and time to the expert as well as the layperson. One of the most interesting models which came up with Einstein's theory was developed by Kurt Gödel in 1949. The Gödel universe is a valid solution of Einstein's field equations, making it a possible physical description of our universe. It offers remarkable features like the existence of an optical horizon beyond which time travel is possible. Although we know that our universe is not a Gödel universe, it is interesting to visualize physical aspects of a world model resulting from a theory which is highly confirmed in scientific history. Standard techniques to adopt an egocentric point of view in a relativistic world model have shortcomings with respect to the time needed to render an image as well as difficulties in applying a direct illumination model. In this paper we want to face both issues to reduce the gap between common visualization standards and relativistic visualization. We will introduce two techniques to speed up recalculation of images by means of preprocessing and lookup tables and to increase image quality through a special optimization applicable to the Gödel universe. The first technique allows the physicist to understand the different effects of general relativity faster and better by generating images from existing datasets interactively. By using the intrinsic symmetries of Gödel's spacetime which are expressed by the Killing vector field, we are able to reduce the necessary calculations to simple cases using the second technique. This even makes it feasible to account for a direct illumination model during the rendering process. Although the presented methods are applied to Gödel's universe, they can also be extended to other manifolds, for example light propagation in moving dielectric media. Therefore, other areas of research can benefit from these generic improvements.

  7. [Revista de Gastroenterologia del Peru: 25 years].

    PubMed

    Celestino Fernández, Alvaro

    2005-01-01

    In this article is described in a very summarized form the history of the Revista de Gastroenterología del Perú (RGP) that dates from the same origins of the Sociedad de Gastroenterología del Perú, when based in October 30 of 1952 already glimpse the presence of the RGP as the official organ for the publication for studies of doctors of the society or foreign guests. We spent 29 years, and this idea becomes reality; and today the RGP turns to their XXV anniversary. The RGP, to locate itself as the Peruvian medical publication best reputation.

  8. Manual del McVCO 1999

    USGS Publications Warehouse

    McChesney, P.J.

    1999-01-01

    El McVCO es un generador de frecuencias basado en un microcontrolador que reemplaza al oscilador controlado por voltaje (VCO) utilizado en telemetría analógica de datos sísmicas. Acepta señales de baja potencia desde un sismómetro y produce una señal subportadora modulada en frecuencia adecuada para enlaces telefónicos o vía radio a un lugar remoto de recolección de datos. La frecuencia de la subportadora y la ganancia pueden ser seleccionadas mediante un interruptor. Tiene la opción de poder operar con dos canales para la observación con ganancia alta y baja. El McVCO fue diseñado con el propósito de mejorar la telemetría analógica de las señales dentro de la Pacific Northwest Seismograph Network (PNSN) (Red Sismográfica del Noroeste del Pacífico). Su desarrollo recibió el respaldo del Programa de Geofísica de la Universidad de Washington y del "Volcano Hazards and Earthquake Hazards programs of the United States Geological Survey (USGS) (Programa de Investigaciones de Riesgos Volcánicos y Programa de Investigaciones de Riesgos Sísmicos de los EEUU). Cientos de instrumentos se han construido e instalado. Además de utilizarlo el PNSN, el McVCO es usado por el Observatorio Vulcanológico de Alaska para monitorear los volcanes aleutianos y por el USGS Volcano Disaster Assistance Program (Programa de Ayuda en las Catástrofes Volcánicas del USGS) para responder a crisis volcánicas en otros países. Este manual cubre el funcionamiento del McVCO, es una referencia técnica para aquellos que necesitan saber con más detalle cómo funciona el McVCO, y cubre una serie de temas que requieren un trato explícito o que derivan del despliegue del instrumento.

  9. [Chromosomal abnormalities in patients from Obstetrics and Gynaecology hospital].

    PubMed

    Hernández-Herrera, Ricardo Jorge; Rojas-Patlán, Luz; Garza-Pérez, Rosa María; Dávila-Rodríguez, Martha; Cortés-Gutiérrez, Elva Irene; García-Rodríguez, Emerson Odón; Hernández-Hernández, Roberto Raúl

    2014-01-01

    INTRODUCCIÓN: las anormalidades cromosómicas se presentan en 2 a 4 % de los recién nacidos y causan 20 % de las muertes en el primer año de vida. Su prevalencia es de uno por cada 500 a 1000 recién nacidos vivos. Pueden ser numéricas o estructurales y afectar a los cromosomas autosómicos o sexuales. Se presentan en 1 a 3 % de la población general y en 6 a 7 % de los individuos con anomalías congénitas. MÉTODOS: estudio descriptivo en el que se incluyeron todos los resultados citogenéticos de cariotipos tomados de sangre periférica de adultos y neonatos. Se evaluó la prevalencia de polimorfismos y alteraciones cromosómicas en derechohabientes del Hospital de Ginecoobstetricia 23 del Instituto Mexicano del Seguro Social, en Monterrey, Nuevo León.

  10. 33 CFR 80.1118 - Marina Del Rey, CA.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Marina Del Rey, CA. 80.1118 Section 80.1118 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Pacific Coast § 80.1118 Marina Del Rey, CA. (a) A line drawn from Marina Del Rey Breakwater South Light...

  11. Vigilando la Calidad del Agua de los Grandes Rios de la Nacion: El Programa NASQAN del Rio Grande (Rio Bravo del Norte)

    USGS Publications Warehouse

    Lurry, Dee L.; Reutter, David C.; Wells, Frank C.; Rivera, M.C.; Munoz, A.

    1998-01-01

    La Oficina del Estudio Geologico de los Estados Unidos (U.S. Geological Survey, 0 USGS) ha monitoreado la calidad del agua de la cuenca del Rio Grande (Rio Bravo del Norte) desde 1995 como parte de la rediseiiada Red Nacional para Contabilizar la Calidad del Agua de los Rios (National Stream Quality Accounting Network, o NASOAN) (Hooper and others, 1997). EI programa NASOAN fue diseiiado para caracterizar las concentraciones y el transporte de sedimento y constituyentes quimicos seleccionados, encontrados en los grandes rios de los Estados Unidos - incluyendo el Misisipi, el Colorado y el Columbia, ademas del Rio Grande. En estas cuatro cuencas, el USGS opera actualmente (1998) una red de 40 puntos de muestreo pertenecientes a NASOAN, con un enfasis en cuantificar el flujo en masa (la cantidad de material que pasa por la estacion, expresado en toneladas por dial para cada constituyente. Aplicacando un enfoque consistente, basado en la cuantificacion de flujos en la cuenca del Rio Grande, el programa NASOAN esta generando la informacion necesaria para identificar fuentes regionales de diversos contaminantes, incluyendo sustancias qui micas agricolas y trazas elementos en la cuenca. EI efecto de las grandes reservas en el Rio Grande se puede observar segun los flujos de constituyentes discurren a 10 largo del rio. EI analisis de los flujos de constituyentes a escala de la cuenca proveera los medios para evaluar la influencia de la actividad humana sobre las condiciones de calidad del agua del Rio Grande.

  12. Hopeful (protein InDel) monsters?

    PubMed

    Tóth-Petróczy, Agnes; Tawfik, Dan S

    2014-06-10

    In this issue of Structure, Arpino and colleagues describe in atomic detail how a protein stomachs a deletion within a helix, an event that rarely occurs in nature or in the lab. Can insertions and deletions (InDels) trigger dramatic structural transitions?

  13. Near Infrared Photometry of Nova Del 2013

    NASA Astrophysics Data System (ADS)

    Cass, A. C.; Carlon, R. L.; Corgan, D. T.; Dykhoff, D. A.; Gehrz, R. D.; Shenoy, D. P.

    2013-09-01

    We continued to follow Nova Del 2013 during the period from 31.15 August 2013 UT through 25.18 September 2013 UT using an As:Si bolometer mounted on the 0.76-m infrared telescope of the University of Minnesota's O'Brien Observatory (Marine on St. Croix, Minnesota, USA). Vega (alpha Lyrae) is used as the standard star.

  14. del and Gödel-type universes in Brans-Dicke theory

    NASA Astrophysics Data System (ADS)

    Agudelo, J. A.; Nascimento, J. R.; Petrov, A. Yu.; Porfírio, P. J.; Santos, A. F.

    2016-11-01

    In this paper, conditions for existence of Gödel and Gödel-type solutions in Brans-Dicke (BD) scalar-tensor theory and their main features are studied. The consistency of equations of motion, causality violation and existence of CTCs (closed time-like curves) are investigated. The role which cosmological constant and Mach principle play to achieve the consistency of this model is studied.

  15. [Association of stress hyperglycemia and in-hospital complications].

    PubMed

    Galindo-García, Gerardo; Galván-Plata, María Eugenia; Nellen-Hummel, Haiko; Almeida-Gutiérrez, Eduardo

    2015-01-01

    Introducción: la hiperglucemia de estrés es la elevación de la glucosa sérica que se encuentra a la admisión hospitalaria de un paciente. El objetivo fue evaluar el impacto de la hiperglucemia de estrés al ingreso en el desenlace de pacientes no críticos hospitalizados en un servicio de Medicina Interna. Métodos: estudio de cohorte prospectivo y analítico realizado en pacientes de Medicina Interna del Hospital de Especialidades del Centro Médico Nacional Siglo XXI del Instituto Mexicano del Seguro Social, de septiembre de 2011 a febrero de 2012. Resultados: se incluyeron 89 pacientes con niveles séricos de glucosa < 110 mg/dL (grupo A) y 90 pacientes con niveles de glucosa > 110 mg/dL (grupo B). La diabetes mellitus fue más frecuente en el grupo B (p < 0.001). La hemoglobina glucosilada mayor a 6.5 % se encontró en el 36.4 % de los pacientes del grupo B y en el 8.7 % del grupo A, (p < 0.001). Los pacientes del grupo B tuvieron mayor puntuación en el APACHE II (p = 0.02) y tendencia a mayor frecuencia de complicaciones. Conclusiones: la hiperglucemia de estrés se asocia a una mayor puntuación de APACHE II, y tiende a una mayor frecuencia de enfermedad crítica, sepsis, infección de vías urinarias, neumonía y uso de aminas vasopresoras. Los predictores independientes de muerte fueron la presencia de hipertensión arterial y el score APACHE II.

  16. The Punta del Cobre Formation, Punta del Cobre Candelaria area, northern Chile

    NASA Astrophysics Data System (ADS)

    Marschik, Robert; Fontboté, Lluís.

    2001-09-01

    The Punta del Cobre Formation hosts the iron oxide-rich Cu-Au(-Zn-Ag) deposits of the Punta del Cobre belt, Chile. Hydrothermal alteration associated with mineralization and/or contact metamorphism caused by the Coastal Batholith exposed in the west resulted in new mineral assemblages and significant changes in the geochemical composition of its rocks. This paper presents a redefinition of the Punta del Cobre Formation and discusses its geologic context. The Punta del Cobre Formation is subdivided, from bottom to top, into: (1) the 'Geraldo-Negro Member', composed mainly of massive andesitic volcanic rocks (>300 m) and locally dacitic rocks (up to 200 m) that overlie the latter, and (2) the 'Algarrobos Member' (up to >800 m) comprising mainly volcaniclastic rocks, basalt andesitic and basaltic flows, and volcanic breccias. The Punta del Cobre Formation is overlain by the Chañarcillo Group, the lowest part of which is represented by alternating carbonate and volcaniclastic beds of the Abundancia Formation, which pass vertically and laterally into limestones of the Nantoco Formation. The contact between the Punta del Cobre Formation and the overlying Abundancia Formation is transitional and defined by the first continuous bed of massive limestone or its metamorphosed equivalent. A pre-upper Valanginian age for the Punta del Cobre Formation is suggested by ammonites of Berriasian age found in the upper part of the Algarrobos Member and Late Valanginian-Early Hauterivian fauna in the overlying Abundancia Formation. Despite the intense alteration, immobile element compositions of the volcanic rocks of the Punta del Cobre Formation enable the recognition of a calc-alkaline suite with a trend to more primitive, less differentiated magmas towards the top of the stratigraphic sequence, reflecting initial stages of basin development. The transgressive nature of the sedimentary part of the Punta del Cobre Formation marks the onset of increased subsidence that eventually

  17. Del Norte means north to recycling

    SciTech Connect

    Aquino, J.T.

    1998-06-01

    Del Norte Regional Recycling and Transfer Station is owned by the city of Oxnard, California and operated by BLT Enterprises, Inc. The Del Norte facility--located in southwestern Ventura County about an hour northwest of Los Angeles--processes polyethylene terephthalate (PET) and high-density polyethylene (HDPE) plastic containers, aluminum, steel, glass, old corrugated containers (OCC), newspapers, computer printout paper, white and colored ledger paper, coated book, supermix paper, telephone books, and old magazines. According to the company, there has been virtually no community opposition to the site. The facility has few neighbors, and those are agricultural. To keep the community relationship strong, the facility`s design and location all but eliminated odor and noise complaints. The building was designed against the prevailing wind pattern, and BLT processes odorous material fast. A misting system installed for dust suppression also can be used with a solution for odor control should the need arise.

  18. Procesamiento Digital de Imagenes del Cometa Halley

    NASA Astrophysics Data System (ADS)

    Ferrin, L.; Fuenmayor, F.; Naranjo, O.; Bulka, P.; Mendoza, C.

    1987-05-01

    Se reportan observaciones fotográficas del cometa Halley, obtenidas con los telescopios Schmidt de 1-m del CIDA, y de 35 cms de la ULA. Se hicieron exposiciones desde 2 segundos a 30 minutos y se utilizaron emulsiones IIa-O, 103a-F, y 103a-D, guladas manualmente 0 automaticámente. Las imágenes fueron digitalizadas con el microdensitómetro PDS, y procesadas con el sistema HACIENDA del CCIBM. Se experimentó con la Transformada de Fourier en dos dimensiones, y con la aplicación de filtros de paso alto y bajo. Se encontró que el metodo de "autocorrelación" es el mejor para separar "la vegetación" de "la montaña". Se aplicaron diversas técnicas a fin de cubrir ambos extremos: a) enfatizar detalles débiles en la cola, y b) penetrar en las regiones más intensas de la coma. Se lograron ambos objetivos. Detalles en la cola permitieron determinar velocidades de propagación de unos 50 a 90 kms/ seg. Se pudieron detectar no menos de tres perturbaciones en "Y", y una en 5? Co de Cisne). Se cree que las primeras están asociadas a eventos de desconexión. Se puede separar la cola de gas de la de polvo. Las fotos de color permiten enfatizar diferentes regiones espectrales con mayor claridad aún. El "balance" del color puede ser hecho con la computadora.

  19. del, Einstein, Mach, Gamow, and Lanczos: Gödel's remarkable excursion into cosmology

    NASA Astrophysics Data System (ADS)

    Rindler, Wolfgang

    2009-06-01

    This article is an expanded version of a talk given at the International Symposium Celebrating the 100th Birthday of Kurt Gödel (Vienna, 2006). It seeks to trace the path which led this preeminent mathematical logician to discover one of the famous results of General Relativity, the rotating Gödel Universe. This universe has some remarkable properties, which gave the philosophers plenty to worry about. It allows a person to travel into his own past, with all the ensuing causal paradoxes; it allows no unique temporal ordering of events; and though Gödel's Universe is rigid and infinite, the Foucault pendulum planes everywhere in it rotate in unison, a clear affront to adherents of Mach's Principle. We also discuss some lesser known precursors in the field, who just missed discovering Gödel's universe. While the article gives all the necessary derivations in simplified form (for example, of the metric and its geodesics), much of it should be accessible to the general reader, who can simply skip most of the mathematics. [Reprinted, with permission, from Kurt Gödel and the Foundations of Mathematics: Horizons of Truth, edited by Matthias Baaz, Christos H. Papadimitriou, Dana S. Scott, Hilary Putnam, and Charles L. Harper, Jr. (Cambridge U. P., New York, 2009).

  20. Visualization of the Gödel universe

    NASA Astrophysics Data System (ADS)

    Buser, M.; Kajari, E.; Schleich, W. P.

    2013-01-01

    The standard model of modern cosmology, which is based on the Friedmann-Lemaître-Robertson-Walker metric, allows the definition of an absolute time. However, there exist (cosmological) models consistent with the theory of general relativity for which such a definition cannot be given since they offer the possibility for time travel. The simplest of these models is the cosmological solution discovered by Kurt Gödel, which describes a homogeneous, rotating universe. Disregarding the paradoxes that come along with the abolishment of causality in such space-times, we are interested in the purely academic question of how an observer would visually perceive the time travel of an object in Gödel's universe. For this purpose, we employ the technique of ray tracing, a standard tool in computer graphics, and visualize various scenarios to bring out the optical effects experienced by an observer located in this universe. In this way, we provide a new perspective on the space-time structure of Gödel's model.

  1. Carcinoma de tumor primario desconocido—Versión para profesionales de salud

    Cancer.gov

    Información del Instituto Nacional del Cáncer para profesionales de salud sobre el tratamiento del carcinoma de tumor primario desconocido, así como referencias a estudios clínicos y otros temas relacionados.

  2. Tumores carcinoides gastrointestinales—Versión para profesionales de salud

    Cancer.gov

    Información del Instituto Nacional del Cáncer para profesionales de salud sobre el tratamiento del tumor carcinoide gastrointestinal, así como referencias a estudios clínicos y otros temas relacionados.

  3. Morphology, geology and geochemistry of the "Salar del Gran Bajo del Gualicho" (Rio Negro, Argentina)

    USGS Publications Warehouse

    Angelucci, A.; Barbieri, M.; Brodtkorb, A.; Ciccacci, S.; Civitelli, G.; De Barrio, R.; Di, Filippo M.; Fredi, P.; Friedman, I.; Lombardi, S.; Schalamuk, A.I.; Toro, B.

    1996-01-01

    A multidisciplinary study of the Gran Bajo del Gualicho area (Rio Negro - Argentina) was carried out; the aim was to delineate its geological and geomorphological evolution and to estabilish the genesis of salts filling the depression. Climatic conditions were analized first to individuate their role in the present morphogenetic processes; moreover the main morphological features of present landscape were examined as well as the stratigraphy of the outcropping formations, and of the Gran Bajo del Gualicho Formation in particular. Finally, a possible geomorphological evolution of the studied area was traced. Geophysical analyses allowed to estabilish that the paleosurface shaped on the crystalline basement is strongly uneven and shows evidence of the strong tectonic phases it underwent. The result of isotope analyses confirmed that the salt deposits on the Gran Bajo del Gualicho bottom were produced by fresh water evaporation, while strontium isotope ratio suggested that such waters were responsible for solubilization of more ancient evaporitic deposits.

  4. [Educational status and life expectancy in patients with chronic non-communicable diseases].

    PubMed

    Villarreal-Hernández, Liliana del Sagrario; Romo-Martínez, Jesús Eduardo

    2014-01-01

    INTRODUCCIÓN: una enfermedad crónica no transmisible, el nivel educativo bajo y los bajos ingresos económicos pueden hacer sinergia y contribuir a un mal pronóstico en cuanto a la expectativa de vida esperada. Se estima que alcanzar un mejor nivel de educación hace posible que mejore la expectativa de vida. El objetivo de esta investigación fue explorar esta relación. MÉTODOS: estudio de cohorte retrospectivo realizado del 1 de enero de 1999 al 31 de diciembre de 2011, de individuos que fallecieron por enfermedades crónicas no transmisibles. Se incluyeron 2306 pacientes registrados en el Sistema de Información en Mortalidad de la Unidad de Medicina Familiar 3, Instituto Mexicano del Seguro Social, en Guadalajara, Jalisco. Se registró la edad al momento de la muerte y el nivel educativo. Las pruebas estadísticas aplicadas fueron t de Student y 2. Se calculó el riesgo relativo.

  5. Kurt Gödels Brünner Verwandte

    NASA Astrophysics Data System (ADS)

    Müller, Dora

    2007-11-01

    The author of this memoir Dora Müller (born 1920) belongs - as well as Kurt Gödel-to the German minority playing an important role in the past life of Brno. The marriage of his son included her among the Gödels collaterals. She was chemist, but also pianist, historician, participant of antinacist movement and iniciator of Czech-German understanding after war. Following her personal experiences, remembrances of Gödels relatives and documental materials, she evokes the atmosphere of broader family milieu of Kurt Gödel.

  6. An evening at "La Clinica del Pueblo".

    PubMed

    Shefsky, M L

    1986-01-01

    This article describes a typical evening at the Clinica del Pueblo in the Hispanic neighborhood of Adams-Morgan in Washington, D.c. The Clinical del Pueblo began operating in 1983 in response to the urgen medical needs of Central American refugees arriving in the Washington D.c. area. The refugees bring with them severe trauma, fear, and health problems caused by the civil was and exacerbated by inadequate or non-existant health services. Approximately 80,000 Salvadoran refugees live in the area. They do not receive adequate health care for 3 reasons. 1) Because the US goverment is unwilling to recognize them as true refugees, they live with the constant threat of deportatin back to the violence from which they have fled. 2) Refugees lack the ability to pay for private care. 3) Langauage and culture create frightening barriers to health care for the refugees. For those who do seek care, these barriers can lead to the inadequate or incomplete diagnoses and poor compliance and follow-up. Plenty International and the Central American Refugee Center responded to these problems by organizing a free clinic to provide not only medical care but also a training course for volunteers. The director of the clinic organizes the course, the classes are taught by a variety of people including the clinic's volunteer physicians, nurses, and public health educators as well as graduates of previus training courses and people from the wider community. The services of the clinic reach only a small portion of the population in need. However, the fact that free medical services are now available to some Central American refugees make the Clinica del Pueblo an important program.

  7. Huave de San Mateo del Mar, Oaxaca (Huave of San Mateo del Mar, Oaxaca).

    ERIC Educational Resources Information Center

    Mexico Coll. (Mexico City)

    This document is one of 17 volumes on indigenous Mexican languages and is the result of a project undertaken by the Archivo de Lenguas Indigenas de Mexico. This volume contains information on Huave, an indigenous language of Mexico spoken in San Mateo del Mar, in the state of Oaxaca. The objective of collecting such a representative sampling of…

  8. Near Infrared Photometry of Nova Del 2013

    NASA Astrophysics Data System (ADS)

    Cass, C. A.; Carlon, L. R.; Corgan, T. D.; Dykhoff, A. D.; Gehrz, D. R.; Shenoy, P. D.

    2013-08-01

    Subjects: Infra-Red, Nova We report RIJHKLM photometry of Nova Del 2013 taken on August 28.13 UT using an As:Si bolometer mounted on the 0.76-m infrared telescope of the University of Minnesota's O'Brien Observatory (Marine on St. Croix, Minnesota, USA). Vega (alpha Lyrae) was used as the standard star. On this date we find: R = 5.6 +/- 0.1, I = 5.2 +/- 0.1, J = 4.5 +/- 0.1, H = 4.7 +/- 0.1, K = 4.7 +/- 0.1, L = 3.3 +/- 0.2, M = +1.8 +/- 0.3.

  9. 33 CFR 110.65 - Indian River Bay, Del.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Indian River Bay, Del. 110.65 Section 110.65 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.65 Indian River Bay, Del. Beginning at a point...

  10. 33 CFR 110.65 - Indian River Bay, Del.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Indian River Bay, Del. 110.65 Section 110.65 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.65 Indian River Bay, Del. Beginning at a point...

  11. 33 CFR 110.65 - Indian River Bay, Del.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Indian River Bay, Del. 110.65 Section 110.65 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.65 Indian River Bay, Del. Beginning at a point...

  12. Instantánea del cáncer colorrectal

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer colorrectal; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

  13. Pastoral del Nino: Bringing the Abundant Life to Paraguayan Children

    ERIC Educational Resources Information Center

    Austin, Ann Berghout; Aquino, Cyle; Burro, Elizabeth

    2007-01-01

    Pastoral del Nino is transforming children's lives in rural Paraguay. Part of Pastoral Social (Catholic Social Services), Pastoral del Nino's primary focus is to bring "vida en abundancia" (the abundant life) to families by ensuring that mothers survive childbirth and children reach their first birthdays. In addition, the organization promotes…

  14. 33 CFR 110.65 - Indian River Bay, Del.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Indian River Bay, Del. 110.65... ANCHORAGE REGULATIONS Special Anchorage Areas § 110.65 Indian River Bay, Del. Beginning at a point bearing... State highway bridge across Indian River Inlet; thence 174°, 600 feet; thence 264°, 800 feet; thence...

  15. 33 CFR 110.111 - Marina del Rey Harbor, Calif.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Marina del Rey Harbor, Calif. 110.111 Section 110.111 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY ANCHORAGES ANCHORAGE REGULATIONS Special Anchorage Areas § 110.111 Marina del Rey Harbor, Calif. An area...

  16. Instantánea del sarcoma de Kaposi

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el sarcoma de Kaposi; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

  17. Illuminating water and life: Emilio Del Giudice.

    PubMed

    Ho, Mae-Wan

    2015-01-01

    The quantum electrodynamics theory of water put forward by Del Giudice and colleagues provides a useful foundation for a new science of water for life. The interaction of light with liquid water generates quantum coherent domains in which the water molecules oscillate between the ground state and an excited state close to the ionizing potential of water. This produces a plasma of almost free electrons favoring redox reactions, the basis of energy metabolism in living organisms. Coherent domains stabilized by surfaces, such as membranes and macromolecules, provide the excited interfacial water that enables photosynthesis to take place, on which most of life on Earth depends. Excited water is the source of superconducting protons for rapid intercommunication within the body. Coherent domains can also trap electromagnetic frequencies from the environment to orchestrate and activate specific biochemical reactions through resonance, a mechanism for the most precise regulation of gene function.

  18. Illuminating water and life: Emilio Del Giudice.

    PubMed

    Ho, Mae-Wan

    2015-01-01

    The quantum electrodynamics theory of water put forward by Del Giudice and colleagues provides a useful foundation for a new science of water for life. The interaction of light with liquid water generates quantum coherent domains in which the water molecules oscillate between the ground state and an excited state close to the ionizing potential of water. This produces a plasma of almost free electrons favoring redox reactions, the basis of energy metabolism in living organisms. Coherent domains stabilized by surfaces, such as membranes and macromolecules, provide the excited interfacial water that enables photosynthesis to take place, on which most of life on Earth depends. Excited water is the source of superconducting protons for rapid intercommunication within the body. Coherent domains can also trap electromagnetic frequencies from the environment to orchestrate and activate specific biochemical reactions through resonance, a mechanism for the most precise regulation of gene function. PMID:26098522

  19. Características del viento en estrellas Be derivadas del perfil Hα

    NASA Astrophysics Data System (ADS)

    Rohrmann, R.; Cidale, L.

    El estudio teórico de perfiles Hα y su variabilidad en estrellas Be ha sido frecuentemente desarrollado en base a modelos de envolturas circunestelares inhomogéneas, donde la geometría del material es responsable de la forma del perfil dependiendo de la dirección de observación. Nosotros damos una interpretación alternativa y proponemos que la mayoría de las propiedades de esta línea tienen origen en la base de un viento estelar y de una estructura cromosférica anexa a la fotósfera. Encontramos que típicos perfiles Hα en Be, como son los llamados pole-on y winebottle, pueden ser reproducidos cualitativamente sin recurrir a la existencia de una envoltura asimétrica. Analizamos como la línea Hα permite identificar la posible estructura del viento en la región donde éste se inicia.

  20. Estudio teórico del CO2. Orbitales de valencia y del ``core''

    NASA Astrophysics Data System (ADS)

    Olalla Gutiérrez, E.

    Hemos calculado las intensidades de las transiciones E1 a los miembros de las series de Rydberg con origen en los orbitales ``no enlazantes'' del dióxido de carbono, especie de conocida relevancia atmosférica. Se han computado, asimismo, los continuos de fotoionización correspondientes a los distintos canales de ionización, representándolos como densidad espectral de fuerza de oscilador frente a la energía del fotón incidente; mostramos los resultados df/dE para la fotoionización total de esta especie en el intervalo 15-60 eV. Todos los cálculos se han llevado a cabo mediante la formulación Molecular del Método de los Orbitales de Defecto Cuántico, MQDO [1,2]. La calidad de los resultados que presentamos se ha evaluado en base a la comparación con los datos, tanto experimentales como teóricos, disponibles en la bibliografía. El acuerdo encontrado es altamente satisfactorio

  1. [La Medicina del Lavoro: 100 volumes].

    PubMed

    Zocchetti, C

    2009-01-01

    With these pages La Medicina del Lavoro starts its 100th volume, so we have yet another historical occasion to celebrate the oldest occupational health journal in the world that is still publishing. Over the last few years we have had many occasions to celebrate, for example several anniversaries of the Journal (the 80th volume in 1989, 90 years in 1992, 100 years in 2001); the centenary of the foundation of the Clinica del Lavoro "Luigi Devoto" of Milan in 2001; the celebration of the 300 years' anniversary of the publication of De Morbis Artificum Diatriba by Bernardino Ramazzini, and we obviously hope to continue for many years to come in this positive outlook. One hundred volumes makes for a very large collection, with the highs and lows ofthe Journal's history (here we mean the variations in number of pages and physical size of the Journal). It is thanks to the Editors-in-chief(there have been very few so we can cite them all: Luigi Devoto, 1901-1936; Luigi Preti, 1936-1941; Enrico Vigliani, 1943-1992; e Vito Foà, 1992 to the present); the contributors who in various ways and with varying degrees of commitment but always with an exceptional personal participation, that it has been possible to reach 100 volumes, starting with C. Moreschi who, along with Luigi Devoto, was the first and sole editor at the Journal's foundation; up to the present extended and impressive editorial board; the printers (from the first. Tipografia Cooperativa, Via dei Molini in Pavia, to the latest: Casa Editrice Mattioli in Fidenza); the sponsors, including the most evident who, via advertising (rather limited as a matter offact), directly gave information about themselves, but also those who have often been or are behind the scenes, ensuring fundamental support which is not visible; content. articles, news, events, reports, ideas, opinions, photographs, tables, numbers... etc, which are really impossible to sum up. But the true collection which, for obvious reasons, cannot be

  2. 394delTT: a Nordic cystic fibrosis mutation.

    PubMed

    Schwartz, M; Anvret, M; Claustres, M; Eiken, H G; Eiklid, K; Schaedel, C; Stolpe, L; Tranebjaerg, L

    1994-02-01

    In a systematic screening for mutations in the gene encoding the cystic fibrosis transmembrane regulator among Danish cystic fibrosis (CF) patients, we identified a mutation in exon 3 (394delTT); this mutation was found to be relatively common in Denmark. We therefore screened for 394delTT in Sweden and Norway, where it turned out to be the second most frequent mutation, accounting for 4% of all CF mutations. It also occurs with a high frequency in Finland, but has not been found in larger surveys of mutations in the CFTR gene. Thus, 394delTT seems to be a specific Nordic CF mutation.

  3. Living Legacy: A Conversation with Carolina Gomez del Valle.

    ERIC Educational Resources Information Center

    Montessori Life, 1993

    1993-01-01

    Carolina Gomez del Valle has been involved in training other Montessorians in Mexico, Chile, Nicaragua, Peru, and Taiwan. This interview explores her experiences with Montessori education and describes how she has woven her religious training and Montessori philosophy together. (PAM)

  4. Centro para la Salud Mundial (CGH) del NCI

    Cancer.gov

    El Centro para la Salud Mundial (CGH) del NCI coordina actividades de investigación y trabaja con socios nacionales e internacionales para comprender y enfrentar la carga que representa el cáncer a nivel mundial.

  5. Del Pueblo: A School That's "Customade" for Learning

    ERIC Educational Resources Information Center

    Cooper, Terry Touff

    1975-01-01

    The contributions made by Hispanic people to the development of the United States were emphasized through the use of a model bilingual/bicultural program produced by the Del Pueblo Elementary School in Denver, Colorado. (Author/RK)

  6. Estudio del sistema simbiótico AR Pavonis

    NASA Astrophysics Data System (ADS)

    Quiroga, C.; Brandi, E.; Ferrer, O.; García, L.; Barbá, R.

    Se presenta un estudio espectroscópico y polarimétrico de la binaria eclipsante AR Pavonis a partir de observaciones obtenidas con el telescopio de 2.15 m. del CASLEO (San Juan). El estudio de la naturaleza del sistema se realizó a través del análisis de algunos espectros reunidos entre los años 1990 y 1995 y de datos polarimétricos correspondientes al intervalo 1995 y 1997. El análisis espectroscópico indica que AR Pav está compuesta por una gigante roja M3.7 y una componente caliente compacta, con una temperatura mayor a 90000 K y una luminosidad del orden de 500Lsolar. A lo largo del período orbital, las variaciones observadas en flujo y en velocidades radiales, reflejan que las emisiones permitidas se forman en una región que rodea la componente caliente. El estudio de la polarización lineal de AR Pav indica que además de una componente interestelar, existe una componente intrínseca del sistema que varía temporalmente y con la longitud de onda de la luz polarizada. El distinto comportamiento del grado de polarización y del ángulo de posición observado en fases diferentes, sugiere que distintos mecanismos pueden estar actuando, dependiendo de la región de scattering observado a lo largo de la línea de la visual.

  7. 65. Photographer unknown March 1931 DEL NORTE COUNTY, SECTION B, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    65. Photographer unknown March 1931 DEL NORTE COUNTY, SECTION B, HIGHWAY 1, 1-DN-1-B #66A, STA. 166.0+00 WIDENED ROADBED BEFORE COVERING LOG CRIB, 3-31. BACK READS: WIDENING ROAD BED WITH LOGS, APPROX 30 SQUARE & 60 LONG ON DN-1 SEC B STA 156+. Stamped office copy, - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

  8. V339 Del (Nova Del 2013) is a weak non-super-soft X-ray source

    NASA Astrophysics Data System (ADS)

    Page, K. L.; Beardmore, A. P.

    2013-09-01

    V339 Del (Nova Del 2013) is currently being monitored approximately daily by Swift-XRT. X-ray analysis has been complicated due to optical loading caused by photons from the very bright optical source. (For a discussion of optical loading in the XRT, see our help page.) At early times, the data were collected mainly in Windowed Timing mode to mitigate this issue, and no X-ray source was detected (ATel #5283, #5305, #5318).

  9. Un estudio de los NIH indica que el consumo regular de aspirina podría reducir el riesgo de cáncer d

    Cancer.gov

    Las mujeres que toman aspirina diariamente podrían reducir el riesgo de cáncer de ovario en 20 por ciento, de acuerdo con un estudio realizado por científicos del Instituto Nacional del Cáncer (NCI), el cual forma parte de los Institutos Nacionales de la

  10. Estudio de Salud Agrícola

    Cancer.gov

    En 1993, científicos del Instituto Nacional del Cáncer, Instituto Nacional de Ciencias Ambientales y la Agencia de Protección Ambiental de Estados Unidos iniciaron un estudio conocido como Estudio de Salud Agrícola (AHS).

  11. Neoplasias mieloproliferativas y síndromes mielodisplásicos—Versión para profesionales de salud

    Cancer.gov

    Información del Instituto Nacional del Cáncer para profesionales de salud sobre el tratamiento de las neoplasias mieloproliferativas, así como referencias a estudios clínicos y otros temas relacionados.

  12. Alloimmunization of patients by blood units harboring distinct DEL variants.

    PubMed

    St-Louis, Maryse; Lebrun, André; Goldman, Mindy; Lavoie, Marianne

    2013-01-01

    The alloimmunization potential of many RHD variants is unknown, and it can be explored by lookback and traceback studies. Hema-Quebec (HQ) investigated the RHD status of 3980 D- repeat blood donors. Thirteen were found to be RHD positive: 4 RHD*1p, and 1 RHD*487delACAG, which show a Dphenotype;and 1 RHD*885T and 7 RHD*(93-94insT) causing a DEL phenotype when C antigen is present. Look back studies were done to verify the alloimmunization potential of these eight DEL donors. Coincidentally, Canadian Blood Services (CBS)performed a trace back study by investigating the RHD status of donors after aD- recipient developed anti-Dafter transfusion of two D- red blood cell (RBC) units. Donor genotyping was done either manually (HQ) or using the Progenika Bloodchip platform(CBS). Donations were traced through computer records. Letters were sent to hospital blood bank physicians to verify the presence of anti-Din recipients and to donors to request repeat samples.A total of 118 RBC units were transfused, 82 to D- recipients.Anti-D was found in three patients transfused with RHD*(93-94insT) DEL red blood cells. One donor presenting the same DEL variant was involved in the trace back study. Even without strong evidence clearly demonstrating the alloimmunization potential of DEL variants, whenever HQ or CBS identifies a donor harboring a DEL phenotype, his or her D status will be changed from DtoD+ to protect against the potential alloimmunization risk. PMID:24689683

  13. May Gödel's Ideas Be Addressed Philosophically?

    NASA Astrophysics Data System (ADS)

    Dokulil, Miloš

    2007-11-01

    del emphasised philosophy as an important tool in science. Much less is known about his religious background. We should bear in mind that our evaluational perspective differs very much from the one in which Gödel lived. He was personally sure that there must be another existence after death-an afterlife (''of unlimited life span''). As a ''Baptized Lutheran'' he did not include ''Trinity'' in his creed. He was also certain that mind is separate from matter. This text tries to include Libet's ''readiness potential'' into the debate concerning the specificity of the mind. Neither Gödel's identification of materialism with mechanism nor his vision of the ''spirit'' are a viable solution of the problem.

  14. Estudio multifrecuencia del medio interestelar cercano a HD 192281

    NASA Astrophysics Data System (ADS)

    Arnal, E. M.; Cappa, C.; Cichowolski, S.; Pineault, S.; St-Louis, N.

    Una de las causas que modifica la estructura y dinámica del medio interestelar es la acción que los vientos de las estrellas de gran masa ejercen sobre el mismo. En este trabajo, mediante el uso de datos interferométricos obtenidos en la banda de radio en la transición de 21-cm del Hidrógeno neutro y de imágenes de la emisión de continuo en las bandas de 408 y 1420 MHz, de imágenes HIRES del satélite IRAS en 60 y 100 micrones, y de observaciones de continuo obtenidas con radiotelescopios de disco simple en 2695, 4850 y 8350 MHz se ha realizado un estudio multifrecuencia de los efectos que los vientos estelares de HD 192281, una estrella de tipo espectral O5 Vn((f))p, han tenido sobre el medio interestelar que rodea a la misma.

  15. Photometric study of the binary system NN Del

    NASA Astrophysics Data System (ADS)

    Gómez-Forrellad, J. M.; Sánchez-Bajo, F.; Corbera-Subirana, M.; GarcÍa-Melendo, E.; Vidal-Sainz, J.

    We present the results of the differential V light curve analysis of NN Del. We show that NN Del is an EA eclipsing binary system with a period of 99.27 days and a highly eccentric orbit. Photometric solutions obtained using the Russell and the Wilson-Devinney models seem to indicate that both components are very similar in radii and luminosities (assuming a F5 spectral type). Constraints imposed on the V luminosity of the system by the HIPPARCOS data suggest that the components of the system could be subgiants instead of main sequence stars.

  16. Outcome following haematopoietic cell transplantation in patients with myelodysplasia and del (5q) karyotypes.

    PubMed

    Stewart, B; Verdugo, M; Guthrie, K A; Appelbaum, F; Deeg, H J

    2003-12-01

    The deletion (5q) karyotype [del (5q)] in patients with myelodysplastic syndrome (MDS) is considered a good risk feature, while the impact of del (5q) combined with other karyotypic abnormalities [del (5q)+] is less well defined. We analysed the outcome of haematopoietic cell transplants (HCT) in patients with MDS with del (5q) or del (5q)+. Fifty-seven patients, aged 6-72 years, with MDS and del (5q) abnormalities received HCT from related (n = 32) or unrelated (n = 25) donors. By French-American-British (FAB) criteria, 27 patients had refractory anaemia (RA), 10 RA with excess blasts (RAEB), eight RAEB in transformation (RAEB-T) and 12 acute myeloid leukaemia evolving from MDS (tAML). Non-relapse mortality at 1-year post-transplantation was 30% for del (5q) and 38% for del (5q)+ patients. Relapse occurred in one of 20 del (5q) patients and 15 of 37 del (5q)+ patients (P = 0.001). After adjusting for del (5q) status, blast count (<5%) was the only factor significantly associated with relapse-free survival. Patients with del (5q), either as a '5q- syndrome' or with MDS in general, had better outcomes than did patients with del (5q)+. The indication for transplantation in patients with del (5q) was generally severe cytopenias, compared with disease progression to a more advanced FAB stage in patients with del (5q)+. Conceivably, outcome for patients with del (5q)+ would be improved with transplantation earlier in the disease course. PMID:14632779

  17. Cosmogenic Radionuclides in the Campo Del Cielo Iron Meteorite

    NASA Technical Reports Server (NTRS)

    Liberman, R. G.; FernandezNiello, J. O.; Reedy, R. C.; Fifield, L. K.; diTada, M. L.

    2001-01-01

    Cosmogenic Be-10, Al-26, Cl-36, Ca-41, and Ni-59 were measured in the Campo del Cielo iron meteorite. Our results led us to conclude that the pre-atmospheric radius might have been approximately 2 m. Comparisons with other big bodies are also presented. Additional information is contained in the original extended abstract.

  18. 75 FR 21220 - Del Norte Resource Advisory Committee (RAC)

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-23

    ... agency #0;statements of organization and functions are examples of documents #0;appearing in this section...; ] DEPARTMENT OF AGRICULTURE Forest Service Del Norte Resource Advisory Committee (RAC) AGENCY: Forest Service... Rivers National Forest, 1330 Bayshore Way, Eureka, CA 95503 (707) 441-3673; e-mail...

  19. Design, aerodynamics and autonomy of the DelFly.

    PubMed

    de Croon, G C H E; Groen, M A; De Wagter, C; Remes, B; Ruijsink, R; van Oudheusden, B W

    2012-06-01

    One of the major challenges in robotics is to develop a fly-like robot that can autonomously fly around in unknown environments. In this paper, we discuss the current state of the DelFly project, in which we follow a top-down approach to ever smaller and more autonomous ornithopters. The presented findings concerning the design, aerodynamics and autonomy of the DelFly illustrate some of the properties of the top-down approach, which allows the identification and resolution of issues that also play a role at smaller scales. A parametric variation of the wing stiffener layout produced a 5% more power-efficient wing. An experimental aerodynamic investigation revealed that this could be associated with an improved stiffness of the wing, while further providing evidence of the vortex development during the flap cycle. The presented experiments resulted in an improvement in the generated lift, allowing the inclusion of a yaw rate gyro, pressure sensor and microcontroller onboard the DelFly. The autonomy of the DelFly is expanded by achieving (1) an improved turning logic to obtain better vision-based obstacle avoidance performance in environments with varying texture and (2) successful onboard height control based on the pressure sensor. PMID:22617112

  20. Design, aerodynamics and autonomy of the DelFly.

    PubMed

    de Croon, G C H E; Groen, M A; De Wagter, C; Remes, B; Ruijsink, R; van Oudheusden, B W

    2012-06-01

    One of the major challenges in robotics is to develop a fly-like robot that can autonomously fly around in unknown environments. In this paper, we discuss the current state of the DelFly project, in which we follow a top-down approach to ever smaller and more autonomous ornithopters. The presented findings concerning the design, aerodynamics and autonomy of the DelFly illustrate some of the properties of the top-down approach, which allows the identification and resolution of issues that also play a role at smaller scales. A parametric variation of the wing stiffener layout produced a 5% more power-efficient wing. An experimental aerodynamic investigation revealed that this could be associated with an improved stiffness of the wing, while further providing evidence of the vortex development during the flap cycle. The presented experiments resulted in an improvement in the generated lift, allowing the inclusion of a yaw rate gyro, pressure sensor and microcontroller onboard the DelFly. The autonomy of the DelFly is expanded by achieving (1) an improved turning logic to obtain better vision-based obstacle avoidance performance in environments with varying texture and (2) successful onboard height control based on the pressure sensor.

  1. Faculty Activity Analysis in the Universidad Tecnica Del Estado Campuses.

    ERIC Educational Resources Information Center

    Karadima, Oscar

    An analysis of academic activities of college faculty at the eight campuses of Chile's Universidad Tecnica del Estado was conducted. Activities were grouped into seven categories: direct teaching, indirect teaching, research, community services, faculty development, academic administration, and other activities. Following the narrative…

  2. 78 FR 50025 - Del Norte County Resource Advisory Committee

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-16

    ...The Del Norte County Resource Advisory Committee (RAC) will meet in Crescent City, California on the dates listed below. The Committee is authorized under the Secure Rural Schools and Community Self-Determination Act (Act) (Pub. L. 112-141) and operates in compliance with the Federal Advisory Committee Act (FACA) (Pub. L. 92- 463). The purpose of the Committee is to improve collaborative......

  3. Interdisciplinary Unit: La Isla del Encanto (The Enchanted Island).

    ERIC Educational Resources Information Center

    Ford-Guerrera, Rebecca

    This document presents a series of 14 lesson plans in an interdisciplinary Spanish unit on "La isla del encanto/The Enchanted Island." The materials were prepared for students in grades 5 or 6 who have had basic Spanish instruction in previous grades. The students should also be familiar with basic concepts in English such as math computation, map…

  4. Cirugía de los trastornos del comportamiento: el estado del arte

    PubMed Central

    Yampolsky, Claudio; Bendersky, Damián

    2014-01-01

    Introducción: La cirugía de los trastornos del comportamiento (CTC) se está convirtiendo en un tratamiento más común desde el desarrollo de la neuromodulación. Métodos: Este artículo es una revisión no sistemática de la historia, indicaciones actuales, técnicas y blancos quirúrgicos de la CTC. Dividimos su historia en 3 eras: la primera comienza en los inicios de la psicocirugía y termina con el desarrollo de las tícnicas estereotácticas, cuando comienza la segunda era. Ésta se caracteriza por la realización de lesiones estereotácticas. Nos encontramos transitando la tercera era, que comienza cuando la estimulación cerebral profunda (ECP) comienza a ser usada en CTC. Resultados: A pesar de los errores graves cometidos en el pasado, hoy en día, la CTC está renaciendo. Los trastornos psiquiátricos que se más frecuentemente se tratan con cirugía son: depresión refractaria, trastorno obsesivo-compulsivo y síndrome de Tourette. Además, algunos pacientes con agresividad fueron tratados quirúrgicamente. Hay varios blancos estereotácticos descriptos para estos trastornos. La estimulación vagal puede ser usada también para depresión. Conclusión: Los resultados de la ECP en estos trastornos parecen alentadores. Sin embargo, se necesitan más estudios randomizados para establecer la efectividad de la CTC. Debe tenerse en cuenta que una apropiada selección de pacientes nos ayudará a realizar un procedimiento más seguro así como también a lograr mejores resultados quirúrgicos, conduciendo a la CTC a ser más aceptada por psiquiatras, pacientes y sus familias. Se necesita mayor investigación en varios temas como: fisiopatología de los trastornos del comportamiento, indicaciones de CTC y nuevos blancos quirúrgicos. PMID:25165612

  5. Extensión del Formalismo de Orbitales de Defecto Cuántico al tratamiento del efecto Stark (SQDO).

    NASA Astrophysics Data System (ADS)

    Menéndez, J. M.; Martín, I.; Velasco, A. M.

    El estudio experimental de las interacciones de átomos Rydberg altamente excitados con campos eléctricos ha experimentado un creciente interés durante las dos últimas décadas debido, en gran medida, al desarrollo de nuevas técnicas para crear y estudiar átomos Rydberg en el laboratorio. Acompañando a estas nuevas técnicas experimentales, es necesario el desarrollo de modelos teóricos que nos permitan contrastar sus medidas y conocer mejor los fundamentos de los mismos. Desde el punto de vista teórico el conocimiento del desdoblamiento de los niveles energéticos de un átomo en función de la magnitud del campo eléctrico aplicado (lo que se conoce como mapa Stark) es el mejor punto de partida para la descripción del sistema y un prerrequisito fundamental para el cálculo de distintas propiedades atómicas en presencia del campo eléctrico tales como intensidades de transición, umbrales de ionización de campo eléctrico, tiempos de vida, posición y anchura de cruces evitados, etc. En este trabajo presentamos la adaptación del método de orbitales de defecto cuántico [1,2,3] al tratamiento del efecto Stark (SQDO) [4] y su aplicación al cálculo de los desdoblamientos energéticos y fuerzas de oscilador de estados Rydberg en los átomos de Li, Na y K. El propósito de este estudio es, por un lado, desarrollar métodos fiables para la determinación de propiedades atómicas en presencia de campos eléctricos y, por otro, mostrar la fiabilidad de las funciones de onda QDO en la descripción del efecto Stark en sistemas atómicos.

  6. Analisis del contenido curricular de los Documentos Normativos del Programa de Ciencias en el area de biologia para la escuela superior del sistema de educacion publica de Puerto Rico: 1993-2012

    NASA Astrophysics Data System (ADS)

    Davila Montanez, Melissa

    Esta investigacion de naturaleza cualitativa se ocupo de realizar un analisis de contenido documental de los Documentos Normativos del Programa de Ciencias en el area de biologia de la escuela superior del sistema de educacion publica de Puerto Rico del periodo 1993-2012. Los documentos analizados fueron: Guia Curricular, 1995; Marco Curricular, 2003; Estandares de Excelencia, 1996, 2000 y Estandares de Contenido y Expectativas de Grado, 2007. Se indago si hubo cambios en significados en los Componentes Estructurales: Naturaleza de la ciencia, Paradigmas para la ensenanza de la ciencia, Funcion del curriculo formal, Mision de la ensenanza de la ciencia; Contenidos, destrezas y competencias, Estrategias de ensenanza y Evaluacion/Assessment del aprendizaje. El analisis sugiere que no hubo cambios sustanciales en los significados de los Componentes Estructurales. Los documentos estudiados muestran mayormente caracteristicas similares, aunque los documentos mas recientes eran mas descriptivos, explicativos y especificos.

  7. Genomic Copy Number Variations in the Myelodysplastic Syndrome and Acute Myeloid Leukemia Patients with del(5q) and/or -7/del(7q).

    PubMed

    Zhang, Rui; Kim, Young-Mi; Wang, Xianfu; Li, Yan; Lu, Xianglan; Sternenberger, Andrea R; Li, Shibo; Lee, Ji-Yun

    2015-01-01

    The most common chromosomal abnormalities in myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) are -5/del(5q) and -7/del(7q). When -5/del(5q) and -7/del(7q) coexist in patients, a poor prognosis is typically associated. Given that -5/del(5q) and/or -7/del(7q) often are accompanied with additional recurrent chromosomal alterations, genetic change(s) on the accompanying chromosome(s) other than chromosomes 5 and 7 may be important factor(s) affecting leukemogenesis and disease prognosis. Using an integrated analysis of karyotype, FISH and array CGH results in this study, we evaluated the smallest region of overlap (SRO) of chromosomes 5 and 7 as well as copy number alterations (CNAs) on the other chromosomes. Moreover, the relationship between the CNAs and del(5q) and -7/del(7q) was investigated by categorizing the cases into three groups based on the abnormalities of chromosomes 5 and 7 [group I: cases only with del(5q), group II: cases only with -7/del(7q) and group III: concurrent del(5q) and del(7q) cases]. The overlapping SRO of chromosome 5 from groups I and III was 5q31.1-33.1 and of chromosome 7 from groups II and III was 7q31.31-q36.1. A total of 318 CNAs were observed; ~ 78.3% of them were identified on chromosomes other than chromosomes 5 and 7, which were defined as 'other CNAs'. Group III was a distinctive group carrying the most high number (HN) CNAs, cryptic CNAs and 'other CNAs'. The loss of TP53 was highly associated with del(5q). The loss of ETV6 was specifically associated with group III. These CNAs or genes may play a secondary role in disease progression and should be further evaluated for their clinical significance and influence on therapeutic approaches in patients with MDS/AML carrying del(5q) and/or -7/del(7q) in large-scale, patient population study. PMID:26392809

  8. The first century of the "clinica del lavoro" in Milan.

    PubMed

    Bertazzi, Pier Alberto; Foà, Vito

    2005-01-01

    The Clinica del Lavoro was created in Milan at the beginning of the 20th century by Luigi Devotto, who deemed it essential for physicians and health researchers to get involved in the life and health problems of working populations. The main roles of the Clinica del Lavoro were to educate medical students and train physicians; study actual workplaces, examine health and safety hazards and their noxious effects; and create initiatives and services to protect and promote workers' health. Important scientific contributions were made in several fields, including chemical carcinogenesis, effects of mineral and biologicalfibers, mechanism of action of silica dust, methods for the detection and measurements of toxic substances in both the work environment and workers' biological media.

  9. New records of fishes at Isla del Coco, Costa Rica

    USGS Publications Warehouse

    Garrison, V.H.

    1996-01-01

    Isla del Coco lies at 5 degrees 32'N latitude, 87 degrees 04'W longitude and is the sole peak of the Cocos Ridge exposed above sea level. This isolated island formed approximately 2 million years ago. It rises 575 m above the surface of the sea and covers 46 km2 (Castillo et aI., 1988). Five hundred km to the NNE is Costa Rica; 630 km SSW are the Galapagos Islands; 650 km to the E is Isla Malpelo, Colombia; and approximately 8,000 km W lie the Line Islands. Costa Rica claimed Isla del Coco in 1832 and declared it a National Park in 1978. The area of the park was increased to include the adjacent waters 5 km offshore in 1984 and 25 km offshore in 1991.

  10. Biological and behavioral determinants of fertility in Tierra del Fuego.

    PubMed

    Pascual, J; García-Moro, C E; Hernández, M

    2005-05-01

    The reproductive history of 182 women in postreproductive life or near menopause from the Chilean part of Tierra del Fuego was traced back by means of familial interviews. These postmenopausal women represent the population since almost the beginning of the settlement, and their reproductive years were spent on the island. Path analysis was applied to analyze fertility determinants of these women and to propose a complex model of interconnections among factors. The reproductive history of these women is characterized by a long fertile span, a short childbearing period, and low fertility. Age at menarche is relatively late, and the age of the women at first birth is mainly determined by their late age at marriage. The use of contraception is related to both spacing and stopping behaviors. The late age of women at marriage, the rhythm of conception, and practices of contraception are proposed as the main determinants of fertility in Tierra del Fuego.

  11. A model of Nevado del Ruiz Volcano, Colombia

    NASA Astrophysics Data System (ADS)

    Williams, Stanley N.; Meyer, Hansjürgen

    A workshop was held at the Observatorio Vulcanologico de Colombia in Manizales, Colombia, March 28 to April 1, 1988, to review the accumulated data on the disastrous November 13, 1985, eruption and related activity of Nevado del Ruiz volcano (Figure 1). Approximately 30 scientists from eight countries presented data, developed a preliminary model, and addressed the future problems of Ruiz. The volcano (see Figure 2) erupted just prior to the meeting, covering the meeting site with 1-2 mm of ash.The workshop was convened by Stanley N. Williams (Louisiana State University, Baton Rouge) and Hansjürgen Meyer (Universidad del Valle, Cali, Colombia). A special volume of the Journal of Volcanology and Geothermal Research is planned for the papers and letters presented at the workshop, with some additional contributions. Publication is expected in mid-1989.

  12. [Promising networks, fruitful inquiry].

    PubMed

    Frenk, Silvestre

    2014-01-01

    This supplement of the Revista Médica del Instituto Mexicano del Seguro Social includes 10 original contributions, and also six current themes, all of them related to childhood obesity. It is the result of an institutional program that it has been identified as Redes de Investigación Institucional, and it has been promoted and developed by the Coordinación de Investigación of the Instituto Mexicano del Seguro Social.

  13. [Promising networks, fruitful inquiry].

    PubMed

    Frenk, Silvestre

    2014-01-01

    This supplement of the Revista Médica del Instituto Mexicano del Seguro Social includes 10 original contributions, and also six current themes, all of them related to childhood obesity. It is the result of an institutional program that it has been identified as Redes de Investigación Institucional, and it has been promoted and developed by the Coordinación de Investigación of the Instituto Mexicano del Seguro Social. PMID:24866301

  14. Solar adaptive optics at the Observatorio del Teide, Tenerife

    NASA Astrophysics Data System (ADS)

    Soltau, Dirk; Berkefeld, Thomas; Schmidt, Dirk; von der Lühe, Oskar

    2013-10-01

    Observing the Sun with high angular resolution is difficult because the turbulence in the atmosphere is strongest during day time. In this paper we describe the principles of solar adaptive optics exemplified by the two German solar telescopes VTT and GREGOR at the Observatorio del Teide. With theses systems we obtain near diffraction limited images of the Sun. Ways to overcome the limits of conventional AO by applying multiconjugate adaptive optics (MCAO) are shown.

  15. 2. COURSE OF THE LATERAL THROUGH DEL NORTHWEST MAR PARK. ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. COURSE OF THE LATERAL THROUGH DEL NORTHWEST MAR PARK. - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  16. 3. 1939 DROP STRUCTURE IN DEL MAR PARK SURMOUNTED BY ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. 1939 DROP STRUCTURE IN DEL MAR PARK SURMOUNTED BY RECENT PEDESTRIAN BRIDGE. - Highline Canal, Sand Creek Lateral, Beginning at intersection of Peoria Street & Highline Canal in Arapahoe County (City of Aurora), Sand Creek lateral Extends 15 miles Northerly through Araphoe County, City & County of Denver, & Adams County to its end point, approximately 1/4 mile Southest of intersectioin of D Street & Ninth Avenue in Adams County (Rocky Mountain Arsenal, Commerce City Vicinity), Commerce City, Adams County, CO

  17. Determinacion de Caracteristicas Opticas del Telescopio OAN150

    NASA Astrophysics Data System (ADS)

    Galan, M. J.; Cobos, F. J.

    1987-05-01

    En el Observatorio de Calar Alto, en Almería, España, está ubicado un telescopio de 15O-cms de diámetro -construído por REOSC- perteneciente al Observatorio Astronómico Nacional, con sede en Madrid, España. La infraestructura técnica del OAN ha sido tradicionalmente débil y actualmente se está haciendo un esfuerzo por fortalecerla. Existe una información muy limitada del telescopio en general; de su óptica en particular se conocían los valores de los parámetros principales pero sin saber si éstos corresponden a valores teóricos ó de construcción. Por ello se consideró necesario iniciar una investigación para conocer en detalle los valores reales de las componentes ópticas del telescopio, obteniéndose algunos resultados de interés. El primario del telescopio OANl5O es aproximadamente F/3 y el siste ma en su conjunto es F/8.2, con su sistema corrector de campo. En términos generales, la imagen es satisfactoria en todo el campo y, sin sistema corrector, la imagen axial también es buena. En un futuro muy cercano se piensa diseñar instrumentación adicional para este telescopio. Conocer con mayor precisión sus características puede ser de gran utilidad para tal fin, pues se efectúan los cálculos considerando conjuntamente al telescopio y al instrumento.

  18. Inclusion of Visually Impaired in the School Programme Scheduled Visit of the Museu de Astronomia e Ciências Afins (MAST). (Breton Title: Inclusão de Deficientes Visuais no Programa de Visita Escolar Programada do Museu de Astronomia e Ciências Afins (MAST).) Inclusión de Discapacitados Visuales en el Programa Escolar Programado del Museo de Astronomía y Ciencias Afines (MAST)

    NASA Astrophysics Data System (ADS)

    de Oliveira Gonçalves, Carla; da Conceição Barbosa-Lima, Maria

    2013-07-01

    que enfrentan dificultades en la escuela. La inclusión debe estar en todas las instituciones educacionales (formales o no). Nuestro objetivo en el trabajo de final de curso de licenciatura, fue el de presentar un relato de la experiencia de mediación a los alumnos con deficiencias visuales del Instituto Benjamin Constant (IBC) en el Museo de Astronomía y Ciencias Afines (MAST) y las modificaciones y nuevas propuestas para el Programa de Visita Escolar Programada (VEP) a través de un aparato especialmente construido con el cual se puede percibir el cielo en una latitud próxima a la de Rio de Janeiro.

  19. Field Measurements of Respiratory Del13CO2 and Photodegradation

    NASA Astrophysics Data System (ADS)

    van Asperen, H.; Sabbatini, S.; Nicolini, G.; Warneke, T.; Papale, D.; Notholt, J.

    2014-12-01

    Carbon decomposition dynamics have been studied in a variety of ecosystems and its variation can mostly be explained in terms of environmental variables (e.g. temperature and precipitation). However, carbon dynamics in arid, water limited regions have shown to be very different and are still largely unknown. Several studies have indicated the importance of photodegradation, the direct breakdown of organic matter by sunlight, in these arid regions. A FTIR (Fourier Transform Infrared Spectrometer) was set up to continuously measure concentrations of CO2, CH4, N2O, CO as well as del13C in CO2. The FTIR was connected to 2 different flux measurement systems: a Flux Gradient system and 2 flux chambers, providing a continuous data set of gas concentrations and biosphere-atmosphere gas fluxes at different heights and scales. Field measurements showed photodegradation induced carbon fluxes. Also, respiratory del13CO2 was determined by use of Keeling plots, and was determined to vary between -25‰ and -21‰. A clear diurnal pattern in respiratory del13CO2 was found, suggesting either different (dominant) respiratory processes between day and night or the effect of diffusive fractionation.

  20. Modeling Visibility in the EL Paso del Norte Region

    NASA Astrophysics Data System (ADS)

    Fitzgerald, R. M.; Medina, R.; DuBois, D. W.; Novlan, D.

    2013-12-01

    Poor visibility is a subject of growing public concern throughout the U.S, and an active area of research. Its societal impacts in air quality, aviation transport and traffic are significant. Aerosols play a fundamental role in the attenuation of solar radiation, and also affect visibility. The scattering and extinction coefficients of aerosol particles in the Paso del Norte Region have been calculated using the T- matrix model in conjunction with a laser particle counter. Inter-comparison of the model's results of the scattering and absorption coefficients against the corresponding data from a Photoacustic Extinctiometer instrument (which measures in-situ absorption and scattering coefficients of aerosol particles) shows excellent agreement. In addition, the volume-weighted method is used to determine the composite index of refraction which is representative of the aerosols for the Paso del Norte Airshed to obtain information of the type of aerosol particles present in the Airshed. The Single Scattering Albedo has also been retrieved using our methodology to obtain further insight into the type of aerosols present on a given day. Finally, the Koschmieder equation has been used to calculate the visual range or visibility, and was correlated with the PM2.5 and PM10 particle concentration present in the Airshed. Our methodology will allow a better understanding of the size and type of aerosol particles that are most detrimental to the visibility for the Paso del Norte Region.

  1. Los plaguicidas y la contaminacion del medio ambiente Venezolano

    USGS Publications Warehouse

    Stickel, L.F.; Stickel, W.H.

    1972-01-01

    RESUMEN DE RECOMENDACIONES Recomendaciones para el Programa de Investigacion: 1. Establecer un sistema de muestreo biologico para detectar los niveles tendencias de los productos quimicos toxicos en un peque?o numero de si tios representativos. 2. Mantener continua vigilancia de la contaminacion ambiental, mediante la seleccion acertadamente dirigida de las zonas afectadas y de las fuentes de contaminacion. 3. Realizar estudios acerca de las poblaciones de animales silvestres, y del exito de los procesos reproductivos de las especies o grupos clayes de animales que se consideran mas gravemente afectados. 4. Preparar recomendaciones para una accion gubernamental de proteccion al hombre, a la fauna silvestre y al medio ambiente. Recomendaciones para la Accion Administrativa: 1. Establecer limites a la tolerancia de los residuos de plaguicidas en los alimentos. Constituye una medida clave para disminuir la contaminacion ambiental. 2. Establecer normas de calidad del agua para las corrientes, represas, la gos y otros cuerpos. Es la segunda medida clave para reducir la contaminacion del ambiente 3. Exigir un tratamiento adecuado de los efluentes industriales, especialmente antes de que se construyan las nuevas plantas. 4. Exigir a los agricultores que en el uso de plaguicidas sigan los consejos tecnicos autorizados y negar a los vendedores el derecho a recomendar productos por su cuenta. 5. Tomar medidas para recoger y eliminar los recipientes y sobrantes de los plaguicidas.

  2. Estudio multifrecuencia del medio interestelar cercano a HD 192281

    NASA Astrophysics Data System (ADS)

    Arnal, E. M.; Cappa, C. E.; Cichowolski, S.; Pineault, S.; St-Louis, N.

    Una de las causas que modifica la estructura y dinámica del medio interestelar es la acción que los vientos de las estrellas de gran masa ejercen sobre el mismo. En este trabajo, mediante el uso de datos interferométricos obtenidos en la banda de radio en la transición de λ˜21-cm del hidrógeno neutro y de imágenes de la emisión de continuo en las bandas de 408 y 1420 MHz, de imágenes HIRES del satélite IRAS en 60 y 100μm, y de observaciones de continuo obtenidas con radiotelescopios de disco simple en 2695, 4850 y 8350 MHz se ha realizado un estudio multifrecuencia de los efectos que los vientos estelares de HD 192281, una estrella de tipo espectral O5,Vn((f))p, han tenido sobre el medio interestelar que rodea a la misma.

  3. Estrategia innovadora enfocada en parejas del mismo sexo para disminuir la infección del VIH en hombres Latinos

    PubMed Central

    Martinez, Omar; Wu, Elwin; Sandfort, Theo; Shultz, Andrew Z.; Capote, Jonathan; Chávez, Silvia; Moya, Eva; Dodge, Brian; Morales, Gabriel; Porras, Antonio; Ovejero, Hugo

    2014-01-01

    Resumen El VIH es un problema de salud importante dentro de la comunidad latina de los Estados Unidos. Gracias a los esfuerzos de prevención, los niveles de contagio entre los latinos se han mantenido estables por más de una década. Sin embargo, esta población sigue siendo afectada a niveles muy altos, en particular entre hombres que tienen sexo con hombres (HSH), de origen latino y que hablan principalmente el idioma español. Existen varios factores que contribuyen a la transmisión del VIH entre esta población, como son: el uso de drogas; la violencia dentro de la pareja; la presencia de infecciones de transmisión sexual; relaciones sexuales sin protección, dentro y fuera de la pareja; el evadir la búsqueda de recursos (prueba y tratamiento adecuado) por temor a ser discriminado o por su estatus migratorio; la escasez de recursos económicos o estado de pobreza y los patrones relacionados a la migración. En particular, Investigaciones Epidemiológicas de Comportamientos han determinado: cómo algunas dinámicas en parejas están directamente asociadas a los comportamientos sexuales de riesgos. En consecuencia, es necesaria mayor investigación para identificar esas dinámicas, y a su vez, realizar intervenciones dirigidas a la reducción de conductas de riesgo enfocadas en parejas de hombres del mismo sexo. En este escrito, se describe la importancia del uso de las relaciones de pareja como estrategia en la reducción de la trasmisión del VIH/SIDA en HSH de origen latino y que hablan principalmente el idioma español en los Estados Unidos. PMID:25580466

  4. Nova Del 2013 (V339 Del) is now a bright super-soft X-ray source

    NASA Astrophysics Data System (ADS)

    Osborne, Julian P.; Page, Kim; Beardmore, Andrew; Woodward, Chick; Schwarz, Greg; Bode, Mike; Ness, Jan-Uwe; Shore, Steve; Starrfield, Sumner; Wagner, Mark; Walter, Fred

    2013-10-01

    Regular Swift XRT monitoring of nova Del 2013 since our report in ATEL #5470 has revealed a decrease in the high absorbing column affecting the optically thin harder X-ray emission above 1 keV; spectral fits suggest N_H ~ 5x10^22 cm^-2 around day 45 and N_H ~ 1.8x10^22 around day 65 after discovery on Aug 14, 2013.

  5. The 2012 Reactivation of Nevado del Ruiz Volcano, Colombia

    NASA Astrophysics Data System (ADS)

    Ordoñez, M.; Lopez, C.; Cortes, G. P.; Londoño, J.; Battaglia, M.

    2012-12-01

    Nevado Del Ruiz volcano is most known for its tragic November 13, 1985 explosive event, when a small eruption produced an enormous lahar that buried and destroyed the town of Armero in Tolima, causing an estimated 25,000 deaths. Similar but less deadly incidents occurred in 1595 and 1845, again where a small explosive eruption was followed by a large lahar. Other minor explosive events occurred in 1805, 1828-9, and 1989. The Armero tragedy was a major factor in the establishment of a volcano monitoring program in Colombia. The network monitoring Nevado del Ruiz volcano has dramatically improved since the 1985 eruption and now includes geodetic, geophysical, geochemical and visual monitoring. The activity of Nevado Del Ruiz between 1985 and 1991 saw significant increases in seismicity and significant gas emissions with the main eruptive events of November 13, 1985 and September 1st, 1989. The volcano became seismically active again in 1995 and 2002, whit an increase in seismicity, without any gas emission or eruption. In October 2010 the volcano entered in a new phase of unrest with increased seismicity (HB events), deformation and gas emissions, likely associated with a new magma intrusion. In February, 2012 the volcano had a new and significant increase in seismicity (VT-LP), followed in May and June 2012 by small phreatic and phreato-magmatic eruption. This eruptive activity is still ongoing. Deformation measurements at Nevado Del Ruiz volcano have been carried out since just after the tragic eruption of the 13th of November 1985. In 2007 seven new electronic tilt meters were set up to monitor the deformation. Significant uplift was measured from August 2007 to October 2010, for a total cumulative value of more than 500 microradians. From the end of 2011 to July 2012, moderate changes of uplift were detected for a total of 70 microradians. The analysis of these deformation data shows a pattern of surface displacement associated with an intrusion of new magma

  6. Comportamiento del Helio en estrellas químicamente peculiares

    NASA Astrophysics Data System (ADS)

    Malaroda, S. M.; López García, Z.; Leone, F.; Catalano, F.

    Las estrellas químicamente peculiares (CP) se caracterizan por tener deficiencias y sobreabundancias de algunos elementos químicos de hasta 106 veces la abundancia solar. Además presentan variaciones en las líneas espectrales. Se piensa que ello se debe a que los campos magnéticos presentes en este tipo de estrellas son principalmente dipolares, con un eje de simetría diferente del eje de rotación. La distribución de los elementos sobreabundantes y deficientes no es homogénea sobre la superficie estelar y las variaciones observadas serían una consecuencia directa de la rotación estelar. Entre los elementos con abundancia anómala se encuentra el Helio, cuyas líneas tienen intensidades que no son consistentes con una abundancia normal, que no puede ser determinada del modo usual, o sea, considerando una atmósfera con composición solar. Con el fin de determinar la abundancia de este elemento, se inició un estudio de estrellas anómalas de Helio, Hew y He strong. Además se determinarán las abundancias de otros elementos anómalos como ser el Si, Cr, Mg, Mn y Fe. Las mismas se determinan del modo tradicional, o sea: a) medida de los anchos equivalentes de las líneas de los distintos elementos analizados; b) adopción de la temperatura efectiva, gravedad y abundancia del Helio; c) cálculo del modelo de atmósfera d) comparación con las observaciones y reinicio de un proceso iterativo hasta lograr un acuerdo entre todos los parámetros analizados. Las observaciones se llevaron a cabo en el Complejo Astronómico El Leoncito. Se observaron setenta y ocho estrellas anómalas de Helio. En este momento se está procediendo a calcular las abundancias correspondientes a los distintos elementos químicos. Para ello se hace uso de los modelos de Kurucz, ATLAS9. Los cálculos NLTE de las líneas de Helio se llevan a cabo con el programa MULTI y se compararán con los realizados con el programa WIDTH9 de Kurucz (LTE), con el objeto de resaltar la importancia de

  7. Harold Varmus investido bajo juramento como 14.º director d

    Cancer.gov

    Ganador del Premio Nobel, doctor Harold E. Varmus, prestó juramento hoy como 14.º director del Instituto Nacional del Cáncer (NCI).  "Es muy estimulante que estés de regreso con nosotros", dijo la secretaria del Departamento de Salud y Servicios Humanos K

  8. Perk Ablation Ameliorates Myelination in S63del-Charcot–Marie–Tooth 1B Neuropathy

    PubMed Central

    Musner, Nicolò; Sidoli, Mariapaola; Zambroni, Desireè; Del Carro, Ubaldo; Ungaro, Daniela; D’Antonio, Maurizio; Feltri, Maria L.

    2016-01-01

    In peripheral nerves, P0 glycoprotein accounts for more than 20% of myelin protein content. P0 is synthesized by Schwann cells, processed in the endoplasmic reticulum (ER) and enters the secretory pathway. However, the mutant P0 with S63 deleted (P0S63del) accumulates in the ER lumen and induces a demyelinating neuropathy in Charcot–Marie–Tooth disease type 1B (CMT1B)–S63del mice. Accumulation of P0S63del in the ER triggers a persistent unfolded protein response. Protein kinase RNA-like endoplasmic reticulum kinase (PERK) is an ER stress sensor that phosphorylates eukaryotic initiation factor 2 alpha (eIF2alpha) in order to attenuate protein synthesis. We have shown that increasing phosphophorylated-eIF2alpha (P-eIF2alpha) is a potent therapeutic strategy, improving myelination and motor function in S63del mice. Here, we explore the converse experiment: Perk haploinsufficiency reduces P-eIF2alpha in S63del nerves as expected, but surprisingly, ameliorates, rather than worsens S63del neuropathy. Motor performance and myelin abnormalities improved in S63del//Perk+/− compared with S63del mice. These data suggest that mechanisms other than protein translation might be involved in CMT1B/S63del neuropathy. In addition, Perk deficiency in other cells may contribute to demyelination in a non–Schwann-cell autonomous manner. PMID:27095827

  9. Screening for 185delAG in the Ashkenazim.

    PubMed Central

    Richards, C S; Ward, P A; Roa, B B; Friedman, L C; Boyd, A A; Kuenzli, G; Dunn, J K; Plon, S E

    1997-01-01

    A study was initiated to assess interest, educational effectiveness, and implications of genetic testing for the common BRCA1 mutation, 185delAG, in the Ashkenazim. Of 333 individuals who attended group sessions, 309 (92%) participated in the study. Participants were categorized as having negative family history (67%), positive family history (defined, by a relaxed criterion, as one first-degree relative or two second-degree relatives with breast [premenopausal] or ovarian cancer) (22%), positive personal history (7%), and both positive personal history and positive family history (4%). Group education was effective, as shown by the improvement in participant scores from pre- to posteducation tests. For the 289 individuals (94%) who requested testing, the major reasons included concern for their own risk, concern for the risk of their children, and desire to learn about surveillance options. The most common reason given by participants who declined testing was concern about health insurance. Six participants found to be heterozygous for the 185delAG mutation received results and were offered genetic counseling. Participants had consented for additional testing without receiving results and were screened for the 6174delT mutation in BRCA2, and seven were found to be positive. All identified carriers reported at least one first- or second-degree relative with a history of breast or ovarian cancer, although they did not all meet our study criteria for positive family history. Given these outcomes, we conclude that screening for breast and ovarian cancer susceptibility is most appropriate for individuals with a positive personal or positive family cancer history. We propose a guideline for future studies designed to identify individuals who may benefit from genetic testing for inherited breast and ovarian cancer. Images Figure 1 PMID:9150156

  10. Non-seasonality of births in Tierra del Fuego (Chile).

    PubMed

    Pascual, J; García-Moro, C; Hernández, M

    2000-01-01

    Tierra del Fuego is situated at the southern tip of the American continent, which conditions its environmental and climatic characteristics. The colonizing population arrived, at the end of the 19th century, from other Chilean regions (particularly from Chiloé) and diverse European countries, especially Britain and Croatia, but also Germany, Spain and Italy. In the present study, the existence of a seasonal pattern in 5430 births registered in the Chilean population of Tierra del Fuego from 1890 to 1995 was analysed. The analysis showed no seasonal distribution of births in the periods 1890-1920 and from 1946 to the present day, a phenomenon rarely reported in the literature. The absence of seasonality in birth distribution could be related to the great diversity in the origins of the population's families, the constant renovation of this and the declining importance of the administrative capital of the province of Tierra del Fuego, Porvenir, in favour of Punta Arenas, capital of the Magellanic region. In the period of maximum development of the capital of the province, a seasonal pattern was detected with a peak in April and a trough in October, which corresponds with a maximum of conceptions in July and, in general, during the early southern winter and a decline in births from late spring to mid-summer, with a trough in January. This birth distribution is interpreted as a subordination of activity and social life to the annual sheep cycle. In addition to temporal trends, the influence on the observed patterns of environmental parameters, father's occupation, seasonality of marriage and the origin of the parents were analysed.

  11. Gynandromorphs in mosquitoes (Diptera: Culicidae) from Valle del Cauca, Colombia.

    PubMed

    Barreto, Mauricio; Burbano, María E; Barreto, Pablo

    2008-01-01

    Gynandromorphs of Culex nigripalpus Theobald (2), Cx. pedroi Sirivanakarn and Belkin (1) and Aedes albopictus (Skuse) (2) are described. Two individuals of the latter species were reared in the laboratory, while the remaining three specimens were wild-caught with different traps in rural areas in Valle del Cauca department, southwestern Colombia. All of the individuals were mounted on microscopic slides with Canada balsam. From each mosquito, main morphological characteristics are described and illustrated. Due to the paucity of information about this subject, these findings as well as other relevant cases are discussed.

  12. Optical photometry and spectroscopy of Nova Del 2013

    NASA Astrophysics Data System (ADS)

    Tomov, T.; Ilkiewicz, K.; Swierczynski, E.; Belcheva, M.; Dimitrov, D.

    2013-08-01

    We report optical BV photometry and spectroscopy of Nova Del 2013, carried out between August 14.88 UT and August 15.08 UT. Using a 60 cm Cassegrain telescope at the Nicolaus Copernicus University Observatory (Torun, Poland) we estimated the V brightness of the Nova to be 6.31+/-0.02 mag and 6.18+/-0.03 mag on Aug. 14.94 UT and Aug. 15.02 UT respectively. HD 194113 (F2, V=8.00 mag) was used as a comparison star.

  13. Albedo polarimétrico de asteroides del grupo Hungaria

    NASA Astrophysics Data System (ADS)

    Gil-Hutton, R.; Benavidez, P.

    La región del cinturón de asteroides en donde se encuentra el grupo de los Hungarias (a= 1.79 a 1.98 UA, i=15 a 40 grados) es la única zona donde es común encontrar objetos de tipo taxonómico E, caracterizados por altos albedos, colores relativamente neutros y espectros sin detalles. Este tipo de asteroides está relacionado espectralmente con ciertos meteoritos (aubritas) que indican la existencia de episodios de gran calentamiento que ocurrieron durante la formación del Sistema Solar. Como el espectro de los asteroides de tipo E es idéntico a los de tipo M y P, la única forma de clasificar un asteroide en alguno de estos tres tipos taxonómicos es mediante el albedo. En este trabajo se presentan resultados preliminares sobre la determinación polarimétrica de albedos para objetos de este grupo utilizando el polarímetro CASPROF de CASLEO.

  14. 66. Photographer unknown March 1920'S DEL NORTE COUNTY, SECTION B, ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    66. Photographer unknown March 1920'S DEL NORTE COUNTY, SECTION B, HIGHWAY 1. 1-DN 1-B #9, CORDUROY DETOUR INTO CRESCENT CITY, 2-2 (3?). Stamped office copy. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

  15. Content Analysis Schedule for Bilingual Education Programs: Del Valle Bilingual Education Program.

    ERIC Educational Resources Information Center

    Ehrlich, Roselin; Shore, Marietta Saravia

    This content analysis schedule for the Del Valle Bilingual Education Program of Del Valle, Texas, presents information on the history, funding, and scope of the project. Included are sociolinguistic process variables such as the native and dominant languages of students and their interaction. Information is provided on staff selection and the…

  16. Instantánea del cáncer de páncreas

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de páncreas; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

  17. Instantánea del cáncer de pulmón

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de pulmón; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

  18. Instantánea del cáncer de seno (mama)

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de seno (mama); así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

  19. Elaphopsocoides, a new genus of Psocidae (Psocodea: ´Psocoptera´) from Valle del Cauca, Colombia.

    PubMed

    Román-P, Cristian; García Aldrete, Alfonso N; Obando, Ranulfo González

    2014-10-14

    Two new species of Elaphopsocoides n. gen. from Valle del Cauca, Colombia, are here described and illustrated. The new genus is related to Elaphopsocus Roesler, but differs from it mostly in the hypandrial projections and in phallosome structure. The female subgenital plate has a distinct, median, posterior projection. The types are deposited in the Entomology Museum, Universidad del Valle (MUSENUV), Santiago de Cali, Colombia.

  20. Instantánea del cáncer de tiroides

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de tiroides; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

  1. Instantánea del cáncer de cuello uterino

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de cuello uterino; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

  2. Instantánea del cáncer de próstata

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de próstata; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

  3. Instantánea del cáncer de estómago

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de estómago; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

  4. 62. R.L.T., photographer November 1, 1934 DEL NORTE COUNTY, SECTION ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    62. R.L.T., photographer November 1, 1934 DEL NORTE COUNTY, SECTION D, HIGHWAY 1. REDWOOD CLEARING ON EXISTING LINE, 1-DN-71-A #26, R.L.T. 11-1-34. Stamped office copy. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

  5. Primer registro para Peru del genero Nielsonia Young, 1977 (Hemiptera: Cicadellidae: Cicadellinae: Cicadellini)

    Technology Transfer Automated Retrieval System (TEKTRAN)

    En este articulo se reporta por primera vez para el Peru una especies del genero Nielsonia Young, 1977, de material procedente del Departamento de Tumbes. El genero ha sido reportada anteriormente de Ecuador, como unico registro para Sudamerica, y America Central. El unico especimen hembra encontra...

  6. Instantánea del cáncer de esófago

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de esófago; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

  7. Instantánea del cáncer de ovario

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de ovario; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

  8. 60. C.J.T., photographer December 23, 1955 KLAMATH RIVER BRIDGE, DEL ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    60. C.J.T., photographer December 23, 1955 KLAMATH RIVER BRIDGE, DEL NORTE COUNTY, SECTION A, HIGHWAY 1. DN-1-A #538, KLAMATH RIVER BR. FROM SO. END, 12/23/55, C.J.T. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

  9. 63. G.F.H., photographer July 30, 1932 DEL NORTE COUNTY, SECTION ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    63. G.F.H., photographer July 30, 1932 DEL NORTE COUNTY, SECTION A, HIGHWAY 1. 1-DN A #124, STA. 164=00 SHOWING DRAINAGE CONDITIONS, G.F.H., 7-30-32. - Redwood National & State Parks Roads, California coast from Crescent City to Trinidad, Crescent City, Del Norte County, CA

  10. Instantánea del cáncer de endometrio

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de endometrio; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

  11. Instantánea del cáncer de vejiga

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de vejiga; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

  12. Instantánea del cáncer de riñón

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre el cáncer de riñón; así como ejemplos de actividades del NCI y adelantos en la investigación de este tipo de cáncer.

  13. 33 CFR 162.40 - Inland waterway from Delaware River to Chesapeake Bay, Del. and Md. (Chesapeake and Delaware Canal).

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... section in 33 CFR part 207. ... River to Chesapeake Bay, Del. and Md. (Chesapeake and Delaware Canal). 162.40 Section 162.40 Navigation... Bay, Del. and Md. (Chesapeake and Delaware Canal). (a) Applicability. The regulations in this...

  14. Efecto del Programa de Entrenamiento “Manejo del Dolor” en la Documentación de Enfermería en el Expediente Electrónico

    PubMed Central

    Monsiváis, María Guadalupe Moreno; Guzmán, Ma. Guadalupe Interial; Flores, Paz Francisco Sauceda; Arreola, Leticia Vázquez

    2012-01-01

    Resumen En el presente trabajo se muestra la importancia de entrenar al personal de enfermería para mejorar la documentación en el expediente electrónico. Se eligió el manejo del dolor por ser un área prioritaria; una alta proporción de pacientes en período post operatorio cursa con dolor, por lo tanto, la documentación debe ser útil para la toma de decisiones clínicas. Se implementó un programa de entrenamiento denominado “Manejo del Dolor” dirigido al personal de enfermería. Se utilizó la tecnología de la información como herramienta para fortalecer el conocimiento con base en la revisión sistemática de la literatura; el personal de enfermería participante seleccionó la mejor evidencia; posteriormente se trabajó en la transferencia de este conocimiento a la práctica a través del diseño de un protocolo para el manejo del dolor. Se concluye que el conocimiento del manejo del dolor es fundamental para que enfermería documente con mayor precisión sus intervenciones. PMID:24199106

  15. Disruption of cytokeratin-8 interaction with F508del-CFTR corrects its functional defect

    PubMed Central

    Colas, Julien; Faure, Grazyna; Saussereau, Emilie; Trudel, Stéphanie; Rabeh, Wael M.; Bitam, Sara; Guerrera, Ida Chiara; Fritsch, Janine; Sermet-Gaudelus, Isabelle; Davezac, Noëlie; Brouillard, Franck; Lukacs, Gergely L.; Herrmann, Harald; Ollero, Mario; Edelman, Aleksander

    2012-01-01

    We have previously reported an increased expression of cytokeratins 8/18 (K8/K18) in cells expressing the F508del mutation of cystic fibrosis transmembrane conductance regulator (CFTR). This is associated with increased colocalization of CFTR and K18 in the vicinity of the endoplasmic reticulum, although this is reversed by treating cells with curcumin, resulting in the rescue of F508del-CFTR. In the present work, we hypothesized that (i) the K8/K18 network may interact physically with CFTR, and that (ii) this interaction may modify CFTR function. CFTR was immunoprecipitated from HeLa cells transfected with either wild-type (WT) CFTR or F508del-CFTR. Precipitates were subjected to 2D-gel electrophoresis and differential spots identified by mass spectrometry. K8 and K18 were found significantly increased in F508del-CFTR precipitates. Using surface plasmon resonance, we demonstrate that K8, but not K18, binds directly and preferentially to the F508del over the WT human NBD1 (nucleotide-binding domain-1). In vivo K8 interaction with F508del-CFTR was confirmed by proximity ligation assay in HeLa cells and in primary cultures of human respiratory epithelial cells. Ablation of K8 expression by siRNA in F508del-expressing HeLa cells led to the recovery of CFTR-dependent iodide efflux. Moreover, F508del-expressing mice topically treated with K8-siRNA showed restored nasal potential difference, equivalent to that of WT mice. These results show that disruption of F508del-CFTR and K8 interaction leads to the correction of the F508del-CFTR processing defect, suggesting a novel potential therapeutic target in CF. PMID:22038833

  16. Instantánea de los cánceres de cerebro y del sistema nervioso central

    Cancer.gov

    Información sobre las tendencias de incidencia, mortalidad y financiamiento del NCI sobre los cánceres de cerebro y del sistema nervioso central; así como ejemplos de actividades del NCI y adelantos en la investigación de estos tipos de cáncer.

  17. 33 CFR 207.100 - Inland waterway from Delaware River to Chesapeake Bay, Del. and Md. (Chesapeake and Delaware...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... River to Chesapeake Bay, Del. and Md. (Chesapeake and Delaware Canal); use, administration, and... Chesapeake Bay, Del. and Md. (Chesapeake and Delaware Canal); use, administration, and navigation. (a... River to Chesapeake Bay, Del. and Md., between Reedy Point, Delaware River, and Old Town Point...

  18. 33 CFR 207.100 - Inland waterway from Delaware River to Chesapeake Bay, Del. and Md. (Chesapeake and Delaware...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... River to Chesapeake Bay, Del. and Md. (Chesapeake and Delaware Canal); use, administration, and... Chesapeake Bay, Del. and Md. (Chesapeake and Delaware Canal); use, administration, and navigation. (a... River to Chesapeake Bay, Del. and Md., between Reedy Point, Delaware River, and Old Town Point...

  19. 33 CFR 207.100 - Inland waterway from Delaware River to Chesapeake Bay, Del. and Md. (Chesapeake and Delaware...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... River to Chesapeake Bay, Del. and Md. (Chesapeake and Delaware Canal); use, administration, and... Chesapeake Bay, Del. and Md. (Chesapeake and Delaware Canal); use, administration, and navigation. (a... River to Chesapeake Bay, Del. and Md., between Reedy Point, Delaware River, and Old Town Point...

  20. Assessing Glacier Hazards At Ghiacciaio Del Belvedere, Macugnaga, Italian Alps

    NASA Astrophysics Data System (ADS)

    Haeberli, W.; Chiarle, M.; Mortara, G.; Mazza, A.

    The uppermost section of the Valle Anzasca behind and above the community of Macugnaga in the Italian Alps is one of the most spectacular high-mountain land- scapes in Europe, with gigantic rock walls and numerous steep hanging glaciers. Its main glacier, Ghiacciaio del Belvedere at the foot of the huge Monte Rosa east face, is a heavily debris-covered glacier flowing on a thick sediment bed. Problems with floods, avalanches and debris flows from this ice body have been known for extended time periods. Most recently, however, the evolution of this highly dynamic environ- ment has become more dramatic. An outburst of Lago delle Locce, an ice-dammed lake at the confluenec of the tributary Ghiacciaio delle Locce with Ghiacciaio del Belvedere, caused heavy damage in 1979 and necessitated site investigation and con- struction work to be done for flood protection. The intermittent glacier growth ten- dency in the 1970es induced strong bulging of the glacier surface and, in places, caused the glacier tongue to override historical morains and to destroy newly-grown forest stands. A surge-type flow acceleration started in the lower parts of the Monte- Rosa east face during summer 2000, leading to strong crevassing and deformation of Ghiacciaio del Belvedere and extreme bulging of its orographic right margin. High water pressure and accelerated movement lasted into winter 2001/2002: the ice now started overriding the LIA moraine near Rifugio Zamboni of the CAI. In addition but rather independently, a most active detachment zone for rock falls and debris flows developed for several years now in the east face of Monte Rosa, somewhat more to the south of the accelerated glacier movement and at an altitude where relatively warm permafrost must be expected. Besides the scientific interest in these phenomena, the growing hazard potential to the local infrastructure must be considered seriously. Es- pecially potentials for the destabilization of large rock and ice masses in the

  1. Ozone studies in the Paso del Norte region

    NASA Astrophysics Data System (ADS)

    Becerra-Davila, Fernando

    The Paso del Norte region forms the largest contiguous bi-national conglomerate on the US-Mexico border. With a combined population of around 2 million inhabitants, the Paso del Norte region is isolated, more than 500 km away from the nearest urban area of comparable size, thus making it an ideal location for air quality studies of an isolated urban environment. The meteorological conditions leading to a high ozone episode in this region, such as the historical ozone episode of June 2006, are analyzed. It is well known that stagnation and minimal winds, high temperatures, and pressure ridges over the region are conducive to high ozone episodes. In addition, the planetary boundary height is studied to understand its impact on high ozone episodes. Several studies report that ground level ozone non-attainment regulations could be caused not only by local emissions, but also by atmospheric transport. In this work the atmospheric advection of pollutants into the region is analyzed using HYSPLIT backward trajectories. Furthermore, a novel backward trajectory clustering technique is implemented for the summer of 2006. The "ozone weekend effect" (OWE) is a phenomenon by which in some geographical regions ambient ozone concentrations tend to be higher on weekends than on weekdays, despite the lower emissions of ozone precursors during those days. The observed local OWE has never previously been studied in terms of the photolysis rates of four of the main ozone precursors. In this research a novel method that allows the calculation of actinic fluxes, photolysis frequencies and photolysis rates with a high degree of accuracy and reliability has been developed. This method utilizes a combination of the experimental data available for this region in conjunction with a radiative transfer model (TUV model). Three weekend-weekday cases during summers 2006, 2009 and 2010 are studied in this work. In this research, the photolysis impact on the local OWE is studied. The results

  2. Renewable energy load assessment for Boquillas Del Carmen Coahuila, Mexico

    SciTech Connect

    Foster, R.

    1995-08-01

    This report outlines the estimates that were made in 1992 of the potential load requirements for Boquillas del Carmen, a small Mexican village on the northern border of the state of Coahuila, Mexico near Big Bend National Park in southern Texas. The study was made to help determine the possibility that village might be electrified by solar or wind energy. Various estimates of are given of the potential load based on estimates ranging from basic use of lights, radio, television, and small household appliances to microwave ovens, refrigerators, and direct evaporative coolers. The low-energy consumption case was estimated to be at 23.0 kWh/month per residence per month, and the high-energy consumption case (with cooling) was 140.7 kWh/month per residence. On average, the typical residence is occupied by five individuals.

  3. Spatially Controlled Fe Isotope Variations at Torres del Paine

    NASA Astrophysics Data System (ADS)

    Gajos, N.; Lundstrom, C.

    2013-12-01

    Recent advances in mass-spectrometry have identified systematic trends of non-traditional stable isotope variation in igneous rocks with differentiation index. We present new Fe isotope data for the Torres del Paine igneous complex in southern Chile. The multi-composition pluton consists of a 1 km vertical exposure of homogenous granite overlying a contemporaneous and possibly cogenetic 0.5 km mafic gabbro suite. Whereas previous isotopic investigations do little to address variations across important magmatic contacts, this study focuses on a first-of-its-kind spatially dependent non-traditional stable isotope investigation of an igneous pluton. Samples were collected at Torres del Paine in spatially significant transects, focusing on major contacts between country rock, granite and mafic units. Results collected by bracketed double spike MC-ICP-MS (2s precision of ×0.03) show an increase in δ56Fe towards the high silica margins of the pluton with values as high as δ56Fe 0.36. Additionally, the data show a decrease in δ56Fe toward the mafic center of the pluton with δ56Fe values ranging from δ56Fe -0.05 to 0.18. Samples collected on the contact between the granite and mafic complex show intermediate values of δ56Fe= 0.18(×) 0.03. Country rock samples in contact with granite show an isotopically light signature of δ56Fe=0.04 (×) 0.03. Analysis of 50 samples in total show a trend of increasing δ56Fe with SiO2 content. The process responsible for Fe isotope variations remains debated but is suggested to reflect four mechanisms: (1) crustal assimilation, (2) fractional crystallization, (3) late stage fluid exsolution [1] and (4) thermal migration [3]. Preliminary results show that mechanisms #1 and #2 would produce isotopic signatures opposite of those seen at Torres del Paine and other plutonic rocks. Isotopically light Torres country rock samples reveal that assimilation of rocks would not produce the isotopically heavy granites seen at Torres. Based on

  4. Circular structures of Bajada del Diablo (Argentina): geophysical signatures

    NASA Astrophysics Data System (ADS)

    Prezzi, C. B.; Orgeira, M. J.; Martinez, O.; Acevedo, R. D.; Ponce, F.; Goldmann, G.; Magneres, I.; Rabassa, J.

    2016-05-01

    Bajada del Diablo is located in the Northern Patagonian Massif, Chubut, Argentina. The study area includes several circular structures found in Miocene olivine basalts of the Quiñelaf Eruptive Complex and in the Late Pliocene/Early Pleistocene Pampa Sastre conglomerates. An impact origin has been proposed for these circular structures. With the aim of further investigate the proposed impact origin, topographic, gravimetric, magnetic, resistivity, palaeomagnetic and electromagnetic surveys in two circular structures (`8' and `G') located in Pampa Sastre conglomerates and in basalts of the Quiñelaf Eruptive Complex were carried out. The new geophysical results support the hypothesis of an impact origin. However, the confirmation of such an origin through the findings of shock metamorphism evidences and/or the recovery of meteorites remains elusive.

  5. Phytoseiid mites (Acari: Phytoseiidae) from Patagonia and Tierra del Fuego.

    PubMed

    Ferragut, Francisco; Navia, Denise

    2015-07-28

    Predatory phytoseiid mites have been intensively studied and surveyed in the last decades because of their economic importance as biocontrol agents of agricultural pests. However, many regions of the world remain unexplored and the diversity of the family worldwide is still fragmentary. Up to date no phytoseiid species have been collected in the southernmost part of the Earth down to latitude 45º S. In this study Phytoseiidae were sampled from native vegetation in southern Argentina and Chile in the regions of Patagonia and Tierra del Fuego Island. Thirteen species were collected, five of which were previously described and eight, Chileseius australis n. sp., Neoseiulus mapuche n. sp., Typhlodromips valdivianus n. sp., T. fissuratus n. sp., Amblyseius grandiporus n. sp., A. caliginosus n. sp., Typhlodromus (Anthoseius) anomalos n. sp. and Metaseiulus parabrevicollis n. sp. are proposed as new to science and are described and diagnosed.

  6. Near-IR Photometry of Nova Del 2013

    NASA Astrophysics Data System (ADS)

    Cass, C. A.; Carlon, L. R.; Corgan, T. D.; Dykhoff, A. D.; Gehrz, D. R.; Shenoy, P. D.

    2013-08-01

    Subjects: Infra-Red, Nova We report Near-IR photometry of Nova Del 2013 taken with the 0.76-m infrared telescope at the University of Minnesota's O'Brien Observatory (Marine on St. Croix, Minnesota, USA). RIJHKLM photometry were obtained on August 21.17 and 23.13 UT using an AsSi bolometer. Vega (alpha Lyrae) was used as the standard star. Our photometry show: August 21.17 UT: R = 5.1 +/- 0.1, I = 4.6 +/- 0.1, J = 4.6 +/- 0.1, H = 4.1 +/- 0.1, K = 3.9 +/- 0.1, L = 2.7 +/- 0.2, M = +2.2 +/- 0.2.

  7. Deglacial palaeoclimate at Puerto del Hambre, subantarctic Patagonia, Chile

    NASA Astrophysics Data System (ADS)

    Heusser, Calvin J.; Heusser, Linda E.; Lowell, Thomas V.; Moreira M., Andrés; Moreira M., Simón

    2000-02-01

    The primary objective of this study is to further substantiate multistep climatic forcing of late-glacial vegetation in southern South America. A secondary objective is to establish the age of deglaciation in Estrecho de Magallanes-Bahía Inútil. Pollen assemblages at 2-cm intervals in a core of the mire at Puerto del Hambre (53°3621S, 70°5553W) provide the basis for reconstructing the vegetation and a detailed account of palaeoclimate in subantarctic Patagonia. Chronology over the 262-cm length of core is regulated by 20 AMS radiocarbon dates between 14 455 and 10 089 14C yr BP. Of 13 pollen assemblage zones, the earliest representing the Oldest Dryas chronozone (14 455-13 000 14C yr BP) records impoverished steppe with decreasing frequencies and loss of southern beech (Nothofagus). Successive 100-yr-long episodes of grass/herbs and of heath (Empetrum/Ericaceae) before 14 000 14C yr BP infer deglacial successional communities under a climate of increased continentality prior to the establishment of grass-dominated steppe. The Bølling-Allerød (13 000-11 000 14C yr BP) is characterised by mesic grassland under moderating climate that with abrupt change to heath dominance after 12 000 14C yr BP was warmer and not as humid. At the time of the Younger Dryas (11 000-10 000 14C yr BP), grass steppe expanded with a return of colder, more humid climate. Later, with gradual warming, communities were invaded by southern beech. The Puerto del Hambre record parallels multistep, deglacial palaeoclimatic sequences reported elsewhere in the Southern Andes and at Taylor Dome in Antarctica. Deglaciation of Estrecho de Magallanes-Bahía Inútil is dated close to 14 455 14C yr BP, invalidating earlier dates of between 15 800 and 16 590 14C yr BP.

  8. [Epidemiology of dog bite lesions in Tierra del Fuego, Argentina].

    PubMed

    Zanini, Fabián; Padinger, Patricia; Elissondo, María C; Pérez, Héctor

    2008-01-01

    The coexistence between man and dog has resulted in mutual benefits during thousands of years, nevertheless some problems have recently arisen where bite injuries have an important role. The aim of this work was to describe the epidemiological characteristics of dog bite lesions which occurred during a year in Tierra del Fuego. A descriptive observational, transversal study of patients who were admitted with dog bite injuries to clinic and pediatric emergency services of hospitals and health centers was carried out between 3/1/05 and 3/1/06. A total of 382 records were made. The children group represents 49.5%. The group between 5 and 9 year-old was the most affected (44.4%; IC95% 37.2-51.8). In the adult group, that between 15 and 24 year-old was the most affected (29.5%; IC95% 23.2-36.5). More lesions were registered in men (57.6%) than in women (42.4%) (chi2 = 8.6, p = 0.003). During spring and summer months, 56.5% of the lesions were registered. A 72.8% of the incidents occurred on the public highway. Dogs of big size were responsible of 49.7% (IC95% 44.6-54.9) of the injuries. The 89.8% of the incidents were caused by another person's dog. Of the lesions, 55.8% (IC95% 50.6-60.8) were registered in lower extremities and 11% (IC95% 8.1-14.7) in head and neck. These data show that dog bite lesions affect the health and impact in the quality of life of the population of Tierra del Fuego, Argentina.

  9. DEL-1 restrains osteoclastogenesis and inhibits inflammatory bone loss in nonhuman primates.

    PubMed

    Shin, Jieun; Maekawa, Tomoki; Abe, Toshiharu; Hajishengallis, Evlambia; Hosur, Kavita; Pyaram, Kalyani; Mitroulis, Ioannis; Chavakis, Triantafyllos; Hajishengallis, George

    2015-09-30

    DEL-1 (developmental endothelial locus-1) is an endothelial cell-secreted protein that regulates LFA-1 (lymphocyte function-associated antigen-1) integrin-dependent leukocyte recruitment and inflammation in various tissues. We identified a novel regulatory mechanism of DEL-1 in osteoclast biology. Specifically, we showed that DEL-1 is expressed by human and mouse osteoclasts and regulates their differentiation and resorptive function. Mechanistically, DEL-1 inhibited the expression of NFATc1, a master regulator of osteoclastogenesis, in a Mac-1 integrin-dependent manner. In vivo mechanistic analysis has dissociated the anti-inflammatory from the anti-bone-resorptive action of DEL-1 and identified structural components thereof mediating these distinct functions. Locally administered human DEL-1 blocked inflammatory periodontal bone loss in nonhuman primates-a relevant model of human periodontitis. The ability of DEL-1 to regulate both upstream (inflammatory cell recruitment) and downstream (osteoclastogenesis) events that lead to inflammatory bone loss paves the way to a new class of endogenous therapeutics for treating periodontitis and perhaps other inflammatory disorders. PMID:26424570

  10. DEL-1 restrains osteoclastogenesis and inhibits inflammatory bone loss in nonhuman primates

    PubMed Central

    Shin, Jieun; Maekawa, Tomoki; Abe, Toshiharu; Hajishengallis, Evlambia; Hosur, Kavita; Pyaram, Kalyani; Mitroulis, Ioannis; Chavakis, Triantafyllos; Hajishengallis, George

    2015-01-01

    DEL-1 is an endothelial cell-secreted protein that regulates LFA-1-integrin–dependent leukocyte recruitment and inflammation in various tissues. Here we identified a novel regulatory mechanism of DEL-1 in osteoclast biology. Specifically, we showed that DEL-1 is expressed by human and mouse osteoclasts and regulates their differentiation and resorptive function. Mechanistically, DEL-1 inhibited the expression of NFATc1, a master regulator of osteoclastogenesis, in a Mac-1-integrin–dependent manner. In vivo mechanistic analysis has dissociated the anti-inflammatory from the anti-bone resorptive action of DEL-1 and identified structural components thereof mediating these distinct functions. Importantly, locally administered human DEL-1 blocked inflammatory periodontal bone loss in nonhuman primates—a relevant model of human periodontitis. The ability of DEL-1 to regulate both upstream (inflammatory cell recruitment) and downstream (osteoclastogenesis) events that lead to inflammatory bone loss paves the way to a new class of endogenous therapeutics for treating periodontitis and perhaps other inflammatory disorders. PMID:26424570

  11. Spatial shell structure of the novas DQ Her and HR Del

    SciTech Connect

    Pilyogin, L.S.

    1986-03-01

    This paper considers the formation of the spatial shell structure of the novas DQ Her (1934) and HR Del (1967). It is shown that the existence of polar caps is due to the influence of the second component of the system on the angular distribution of the mass shell depth of the mainshell. The ratio of the mass shell depth in the equatorial ring and in the polar caps is 1.13 for DQ Her and 2.7 for HR Del. The ratio of the maximal densities in the equatorial ring and the polar caps is of order 3 for DQ Her and of order 70 for HR Del.

  12. Resultados del relevamiento de HI en el Cielo Austral: 3. Relevamiento de Nubes de Alta Velocidad

    NASA Astrophysics Data System (ADS)

    Morras, R.; Bajaja, E.; Arnal, E. M.; Pöppel, W. G. L.

    Los resultados del relevamiento de HI del Hemisferio Austral fueron reprocesados con el fin de incrementar su sensibilidad. Así, se utilizó esta nueva base de datos con el fin de obtener un nuevo relevamiento de Nubes de Alta Velocidad en el cielo austral. El ruido r.m.s. alcanzado es de 0.015-0.020 K, con una resolución espectral de 8 km/seg. El cubrimiento espacial del relevamiento mejora en un factor 16 al realizado por Bajaja et al (1985).

  13. Observaciones del CH interestelar y el continuo en 3,3 GHz

    NASA Astrophysics Data System (ADS)

    Olano, C. A.; Combi, J. A.; Pöppel, W.; Benaglia, P.; Sanz, A. J.; Bava, J. A.

    Se informa sobre el proyecto que se lleva a cabo en el IAR con el propósito de observar las líneas hiperfinas del estado fundamental del CH y el continuo en la banda de 3,3 GHz. El nuevo receptor construído en nuestro laboratorio para tal fin se instaló sobre uno de los radiotelescopios, funcionando conjuntamente con los sistemas de procesamiento actuales del IAR. Los resultados de las primeras observaciones, realizadas tanto en las líneas espectrales como en el continuo sobre fuentes conocidas, fueron satisfactorios.

  14. General nonextremal rotating charged Gödel black holes in minimal five-dimensional gauged supergravity.

    PubMed

    Wu, Shuang-Qing

    2008-03-28

    I present the general exact solutions for nonextremal rotating charged black holes in the Gödel universe of five-dimensional minimal supergravity theory. They are uniquely characterized by four nontrivial parameters: namely, the mass m, the charge q, the Kerr equal rotation parameter a, and the Gödel parameter j. I calculate the conserved energy, angular momenta, and charge for the solutions and show that they completely satisfy the first law of black hole thermodynamics. I also study the symmetry and separability of the Hamilton-Jacobi and the massive Klein-Gordon equations in these Einstein-Maxwell-Chern-Simons-Gödel black hole backgrounds. PMID:18517852

  15. General Nonextremal Rotating Charged Gödel Black Holes in Minimal Five-Dimensional Gauged Supergravity

    NASA Astrophysics Data System (ADS)

    Wu, Shuang-Qing

    2008-03-01

    I present the general exact solutions for nonextremal rotating charged black holes in the Gödel universe of five-dimensional minimal supergravity theory. They are uniquely characterized by four nontrivial parameters: namely, the mass m, the charge q, the Kerr equal rotation parameter a, and the Gödel parameter j. I calculate the conserved energy, angular momenta, and charge for the solutions and show that they completely satisfy the first law of black hole thermodynamics. I also study the symmetry and separability of the Hamilton-Jacobi and the massive Klein-Gordon equations in these Einstein-Maxwell-Chern-Simons-Gödel black hole backgrounds.

  16. HAER DEL,3MILF.V,2 (sheet 1 of 4) Mispillion Lighthouse, South ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    HAER DEL,3-MILF.V,2- (sheet 1 of 4) - Mispillion Lighthouse, South bank of Mispillion River at its confluence with Delaware River at northeast end of County Road 203, 7 miles east of Milford, Milford, Sussex County, DE

  17. HAER DEL,3MILF.V,2 (sheet 2 of 4) Mispillion Lighthouse, South ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    HAER DEL,3-MILF.V,2- (sheet 2 of 4) - Mispillion Lighthouse, South bank of Mispillion River at its confluence with Delaware River at northeast end of County Road 203, 7 miles east of Milford, Milford, Sussex County, DE

  18. HAER DEL,3MILF.V,2 (sheet 3 of 4) Mispillion Lighthouse, South ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    HAER DEL,3-MILF.V,2- (sheet 3 of 4) - Mispillion Lighthouse, South bank of Mispillion River at its confluence with Delaware River at northeast end of County Road 203, 7 miles east of Milford, Milford, Sussex County, DE

  19. HAER DEL,3MILF.V,2 (sheet 4 of 4) Mispillion Lighthouse, South ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    HAER DEL,3-MILF.V,2- (sheet 4 of 4) - Mispillion Lighthouse, South bank of Mispillion River at its confluence with Delaware River at northeast end of County Road 203, 7 miles east of Milford, Milford, Sussex County, DE

  20. Tumores extracraneales de células germinativas—Versión para pacientes

    Cancer.gov

    Información del Instituto Nacional del Cáncer sobre el tratamiento del tumor extracraneal de células germinativas en los niños, así como referencias a estudios clínicos y otros temas relacionados.

  1. Sarcoma de tejido blando—Versión para profesionales de salud

    Cancer.gov

    Información del Instituto Nacional del Cáncer para profesionales de salud sobre el tratamiento del sarcoma de tejido blando, así como referencias a estudios clínicos, investigación, estadísticas y otros temas relacionados con este tipo de cáncer.

  2. Cáncer de vesícula biliar—Versión para profesionales de salud

    Cancer.gov

    Información del Instituto Nacional del Cáncer para profesionales de salud sobre el tratamiento del cáncer de vesícula biliar, así como referencias a estudios clínicos, investigación y otros temas relacionados con este tipo de cáncer.

  3. Cáncer de pene—Versión para profesionales de salud

    Cancer.gov

    Información del Instituto Nacional del Cáncer para profesionales de salud sobre el tratamiento del cáncer de pene, así como referencias a estudios clínicos, investigación y otros temas relacionados con este tipo de cáncer.

  4. Cáncer de páncreas—Versión para profesionales de salud

    Cancer.gov

    Información del Instituto Nacional del Cáncer para profesionales de salud sobre el tratamiento del cáncer de páncreas, así como referencias a estudios clínicos, investigación y otros temas relacionados con este tipo de cáncer.

  5. Cáncer de testículo—Versión para profesionales de salud

    Cancer.gov

    Información del Instituto Nacional del Cáncer para profesionales de salud sobre el tratamiento, las causas y los exámenes de detección del cáncer de testículo, así como referencias a estudios clínicos, investigación y otros temas.

  6. Cáncer de vulva—Versión para profesionales de salud

    Cancer.gov

    Información del Instituto Nacional del Cáncer para profesionales de salud sobre el tratamiento del cáncer de vulva, así como referencias a estudios clínicos, investigación y otros temas relacionados con este tipo de cáncer.

  7. Cáncer de pene—Versión para pacientes

    Cancer.gov

    Información del Instituto Nacional del Cáncer sobre el tratamiento del cáncer de pene, así como referencias a estudios clínicos, investigación y otros temas relacionados con este tipo de cáncer.

  8. Cáncer de testículo—Versión para pacientes

    Cancer.gov

    Información del Instituto Nacional del Cáncer sobre el tratamiento, las causas y los exámenes de detección del cáncer de testículo, así como referencias a estudios clínicos, investigación y otros temas relacionados con este tipo de cáncer.

  9. Cáncer de paratiroides—Versión para profesionales de salud

    Cancer.gov

    Información del Instituto Nacional del Cáncer para profesionales de salud sobre el tratamiento del cáncer de paratiroides, así como referencias a estudios clínicos, investigación y otros temas relacionados con este tipo de cáncer.

  10. Neoplasias de células plasmáticas (incluso mieloma múltiple)—Versión para pacientes

    Cancer.gov

    Información del Instituto Nacional del Cáncer sobre el tratamiento del mieloma múltiple y otras neoplasias de células plasmáticas, así como referencias a estudios clínicos, investigación, estadísticas y otros temas relacionados.

  11. Accesibilidad | Smokefree Español

    Cancer.gov

    Espanol.smokefree.gov ofrece apoyo y recursos para norteamericanos que hablan español y quieren dejar de fumar. Este sitio en la red fue creada por la División de Investigación para el Control del Tabaco del Instituto Nacional del Cáncer.

  12. Requisitos para utilizar el enlace | Smokefree Español

    Cancer.gov

    Espanol.smokefree.gov ofrece apoyo y recursos para norteamericanos que hablan español y quieren dejar de fumar. Este sitio en la red fue creada por la División de Investigación para el Control del Tabaco del Instituto Nacional del Cáncer.

  13. Descargo de responsabilidad de Smokefree Español | Smokefree Español

    Cancer.gov

    Espanol.smokefree.gov ofrece apoyo y recursos para norteamericanos que hablan español y quieren dejar de fumar. Este sitio en la red fue creada por la División de Investigación para el Control del Tabaco del Instituto Nacional del Cáncer.

  14. Ver Archivos | Smokefree Español

    Cancer.gov

    Espanol.smokefree.gov ofrece apoyo y recursos para norteamericanos que hablan español y quieren dejar de fumar. Este sitio en la red fue creada por la División de Investigación para el Control del Tabaco del Instituto Nacional del Cáncer.

  15. Sobre | Smokefree Español

    Cancer.gov

    Espanol.smokefree.gov ofrece apoyo y recursos para norteamericanos que hablan español y quieren dejar de fumar. Este sitio en la red fue creada por la División de Investigación para el Control del Tabaco del Instituto Nacional del Cáncer.

  16. Cáncer de intestino delgado—Versión para profesionales de salud

    Cancer.gov

    Información del Instituto Nacional del Cáncer para profesionales de salud sobre el tratamiento del cáncer de intestino delgado, así como referencias a estudios clínicos, investigación y otros temas relacionados con este tipo de cáncer.

  17. Cáncer de intestino delgado—Versión para pacientes

    Cancer.gov

    Información del Instituto Nacional del Cáncer sobre el tratamiento del cáncer de intestino delgado, así como referencias a estudios clínicos, investigación y otros temas relacionados con este tipo de cáncer.

  18. Cáncer de útero—Versión para pacientes

    Cancer.gov

    Información del Instituto Nacional del Cáncer sobre el tratamiento, la prevención, las causas y los exámenes de detección del cáncer uterino, así como referencias a estudios clínicos, investigación, estadísticas y otros temas relacionados.

  19. Mesotelioma maligno—Versión para profesionales de salud

    Cancer.gov

    Información del Instituto Nacional del Cáncer para profesionales de salud sobre el tratamiento y las causas del mesotelioma maligno, así como referencias a estudios clínicos y otros temas relacionados con este tipo de cáncer.

  20. Tumores extracraneales de células germinativas—Versión para profesionales de salud

    Cancer.gov

    Información del Instituto Nacional del Cáncer para profesionales de salud sobre el tratamiento del tumor extracraneal de células germinativas en los niños, así como referencias a estudios clínicos y otros temas relacionados.

  1. Sarcoma de tejido blando—Versión para pacientes

    Cancer.gov

    Información del Instituto Nacional del Cáncer sobre el tratamiento del sarcoma de tejido blando, así como referencias a estudios clínicos, investigación, estadísticas y otros temas relacionados con este tipo de cáncer.

  2. Cáncer de tiroides—Versión para profesionales de salud

    Cancer.gov

    Información del Instituto Nacional del Cáncer para profesionales de salud sobre el tratamiento del cáncer de tiroides, así como referencias a estudios clínicos, investigación y otros temas relacionados con este tipo de cáncer.

  3. Retinoblastoma—Versión para profesionales de salud

    Cancer.gov

    Información del Instituto Nacional del Cáncer para profesionales de salud sobre el tratamiento del retinoblastoma, así como referencias a estudios clínicos, estadísticas y otros temas relacionados con este tipo de cáncer.

  4. Cáncer de ano—Versión para profesionales de salud

    Cancer.gov

    Información del Instituto Nacional del Cáncer para profesionales de salud sobre el tratamiento del cáncer de ano, así como referencias a estudios clínicos y otros temas relacionados con este tipo de cáncer.

  5. Cáncer de útero—Versión para profesionales de salud

    Cancer.gov

    Información del Instituto Nacional del Cáncer para profesionales de salud sobre el tratamiento, la prevención, las causas y los exámenes de detección del cáncer uterino, así como referencias a estudios clínicos, investigación, estadísticas y otros temas.

  6. Cáncer de vagina—Versión para profesionales de salud

    Cancer.gov

    Información del Instituto Nacional del Cáncer para profesionales de salud sobre el tratamiento del cáncer de vagina, así como referencias a estudios clínicos, investigación y otros temas relacionados con este tipo de cáncer.

  7. Cáncer de la corteza suprarrenal—Versión para profesionales de salud

    Cancer.gov

    Información del Instituto Nacional del Cáncer para profesionales de salud sobre el tratamiento del carcinoma de corteza suprarrenal, así como referencias a estudios clínicos, investigación y otros temas relacionados con este tipo de cáncer.

  8. Cáncer de uretra—Versión para profesionales de salud

    Cancer.gov

    Información del Instituto Nacional del Cáncer para profesionales de salud sobre el tratamiento del cáncer de uretra, así como referencias a estudios clínicos y otros temas relacionados con este tipo de cáncer.

  9. Cáncer de vejiga—Versión para profesionales de salud

    Cancer.gov

    Información del Instituto Nacional del Cáncer para profesionales de salud sobre el tratamiento, las causas y los exámenes de detección del cáncer de vejiga, así como referencias a estudios clínicos, investigación, estadísticas y otros temas.

  10. Cáncer de piel (incluye el melanoma)—Versión para pacientes

    Cancer.gov

    Información del Instituto Nacional del Cáncer sobre el tratamiento, la prevención, las causas, los exámenes de detección y los estudios clínicos del cáncer de piel, así como referencias a otros temas relacionados con este tipo de cáncer.

  11. Cáncer de vesícula biliar—Versión para pacientes

    Cancer.gov

    Información del Instituto Nacional del Cáncer sobre el tratamiento del cáncer de vesícula biliar, así como referencias a estudios clínicos, investigación y otros temas relacionados con este tipo de cáncer.

  12. Cáncer de vulva—Versión para pacientes

    Cancer.gov

    Información del Instituto Nacional del Cáncer sobre el tratamiento del cáncer de vulva, así como referencias a estudios clínicos, investigación y otros temas relacionados con este tipo de cáncer.

  13. Linfoma—Versión para profesionales de salud

    Cancer.gov

    Información del Instituto Nacional del Cáncer para profesionales de salud sobre el tratamiento del linfoma, así como referencias a estudios clínicos, investigación, estadísticas y otros temas relacionados con este tipo de cáncer.

  14. Neoplasias de células plasmáticas (incluso mieloma múltiple)—Versión para profesionales de salud

    Cancer.gov

    Información del Instituto Nacional del Cáncer para profesionales de salud sobre el tratamiento del mieloma múltiple y otras neoplasias de células plasmáticas, así como referencias a estudios clínicos, investigación, estadísticas y otros temas.

  15. Cáncer de riñón (células renales)—Versión para profesionales de salud

    Cancer.gov

    Información del Instituto Nacional del Cáncer para profesionales de salud sobre el tratamiento del cáncer de riñón, así como referencias a estudios clínicos, investigación, estadísticas y otros temas relacionados con este tipo de cáncer.

  16. Cáncer de piel (incluye el melanoma)—Versión para profesionales de salud

    Cancer.gov

    Información del Instituto Nacional del Cáncer para profesionales de salud sobre el tratamiento, la prevención, las causas y los exámenes de detección del cáncer de piel, así como referencias a estudios clínicos, investigación y otros temas.

  17. Cáncer colorrectal—Versión para profesionales de salud

    Cancer.gov

    Información del Instituto Nacional del Cáncer para profesionales de salud sobre el tratamiento, la prevención, las causas y los exámenes de detección del cáncer de colon y recto, así como referencias a estudios clínicos, estadísticas y otros temas.

  18. Neuroblastoma—Versión para profesionales de salud

    Cancer.gov

    Información del Instituto Nacional del Cáncer para profesionales de salud sobre el tratamiento y los exámenes de detección del neuroblastoma, así como referencias a estudios clínicos, investigación y otros temas relacionados con este tipo de cáncer.

  19. Neuroblastoma—Versión para pacientes

    Cancer.gov

    Información del Instituto Nacional del Cáncer sobre el tratamiento y los exámenes de detección del neuroblastoma, así como referencias a estudios clínicos, investigación y otros temas relacionados con este tipo de cáncer.

  20. El cáncer

    Cancer.gov

    Información del Instituto Nacional del Cáncer sobre el tratamiento, la prevención, los exámenes de detección, la genética y las causas del cáncer, así como formas de hacer frente a la enfermedad.

  1. Cáncer de riñón (células renales)—Versión para pacientes

    Cancer.gov

    Información del Instituto Nacional del Cáncer sobre el tratamiento del cáncer de riñón, así como referencias a estudios clínicos, investigación, estadísticas y otros temas relacionados con este tipo de cáncer.

  2. Linfoma—Versión para pacientes

    Cancer.gov

    Información del Instituto Nacional del Cáncer sobre el tratamiento del linfoma, así como referencias a estudios clínicos, investigación, estadísticas y otros temas relacionados con este tipo de cáncer.

  3. Cáncer de vagina—Versión para pacientes

    Cancer.gov

    Información del Instituto Nacional del Cáncer sobre el tratamiento del cáncer de vagina, así como referencias a estudios clínicos, investigación y otros temas relacionados con este tipo de cáncer.

  4. Cáncer de páncreas—Versión para pacientes

    Cancer.gov

    Información del Instituto Nacional del Cáncer sobre el tratamiento del cáncer de páncreas, así como referencias a estudios clínicos, investigación y otros temas relacionados con este tipo de cáncer.

  5. Cáncer de paratiroides—Versión para pacientes

    Cancer.gov

    Información del Instituto Nacional del Cáncer sobre el tratamiento del cáncer de paratiroides, así como referencias a estudios clínicos, investigación y otros temas relacionados con este tipo de cáncer.

  6. Cáncer de cuello uterino—Versión para pacientes

    Cancer.gov

    Información del Instituto Nacional del Cáncer sobre el tratamiento, la prevención, las causas y los exámenes de detección del cáncer de cuello uterino, así como referencias a estudios clínicos, investigación, estadísticas y otros temas relacionados.

  7. Cáncer de tiroides—Versión para pacientes

    Cancer.gov

    Información del Instituto Nacional del Cáncer sobre el tratamiento del cáncer de tiroides, así como referencias a estudios clínicos, investigación y otros temas relacionados con este tipo de cáncer.

  8. Cáncer colorrectal—Versión para pacientes

    Cancer.gov

    Información del Instituto Nacional del Cáncer sobre el tratamiento, la prevención, las causas y los exámenes de detección del cáncer de colon y recto, así como referencias a estudios clínicos, estadísticas y otros temas relacionados.

  9. Mesotelioma maligno—Versión para pacientes

    Cancer.gov

    Información del Instituto Nacional del Cáncer sobre el tratamiento y las causas del mesotelioma maligno, así como referencias a estudios clínicos y otros temas relacionados con este tipo de cáncer.

  10. Cáncer de hueso—Versión para pacientes

    Cancer.gov

    Información del Instituto Nacional del Cáncer sobre el tratamiento del cáncer de hueso (óseo), así como referencias a estudios clínicos, investigación y otros temas relacionados con este tipo de cáncer.

  11. Cáncer de hueso—Versión para profesionales de salud

    Cancer.gov

    Información del Instituto Nacional del Cáncer para profesionales de salud sobre el tratamiento del cáncer de hueso (óseo), así como referencias a estudios clínicos, investigación y otros temas relacionados con este tipo de cáncer.

  12. Tumores de hipófisis—Versión para profesionales de salud

    Cancer.gov

    Información del Instituto Nacional del Cáncer para profesionales de salud sobre el tratamiento del tumor de hipófisis, así como referencias a estudios clínicos, investigación y otros temas relacionados.

  13. Cáncer de la corteza suprarrenal—Versión para pacientes

    Cancer.gov

    Información del Instituto Nacional del Cáncer sobre el tratamiento del carcinoma de corteza suprarrenal, así como referencias a estudios clínicos, investigación y otros temas relacionados con este tipo de cáncer.

  14. RASTREO DEL CANCER COLORRECTAL CONOCIMIENTO Y ACTITUD DE LA POBLACION

    PubMed Central

    CASAL, ENRIQUE R.; VELAZQUEZ, ELIZABETH N.; MEJIA, RAUL M.; CUNEO, ALDO; PEREZ-STABLE, ELISEO J.

    2014-01-01

    Resumen El rastreo de cáncer colorrectal (CCR) cuenta con fuertes evidencias en su favor. Datos preliminares indican que a pesar de ello no se lleva a cabo con la frecuencia adecuada. Se intenta aquí determinar, dentro de un Sistema de Salud que cuenta con los recursos necesarios, los elementos que facilitan o generan barreras para concretar esta práctica preventiva, cuántos individuos lo ponen en práctica y qué predice esta conducta. Se realizó una encuesta telefónica a los afiliados de una Obra Social de empleados de la Universidad de Buenos Aires, de los que 132 completaron el cuestionario (tasa de respuesta 70%). Los elementos considerados facilitadores del rastreo obtuvieron respuestas afirmativas en el 64 a 97%, mientras que los que definían barreras un 11 a 27%. En este último grupo, una categoría diferenciada la constituía el miedo a los efectos adversos: 39%, y el sentimiento de vergüenza relacionado con los procedimientos: 30%. Un 33% de los encuestados tenían hecho un método de rastreo, mayoritariamente de sangre oculta (27), sigmoideoscopía (11) y colonoscopía (20). Una mayoría afirmó que “se haría el procedimiento si el médico se lo recomendara” (95%), o “no se lo haría excepto que su médico se lo aconseje” (87%). Contestar afirmativamente que “los médicos hacen lo mejor para los pacientes” se asoció con haberse hecho un método de rastreo de CCR, OR 1.55 (IC 95%: 1.02-2.37) p: 0.04. El grupo de individuos estudiado parece bien predispuesto para el rastreo del CCR, la recomendación médica sería aquí un determinante prominente para ponerlo en práctica. PMID:19414294

  15. New genera of Lachesillidae (Psocodea: 'Psocoptera': Eolachesillinae: Graphocaeciliini) from Valle del Cauca, Colombia.

    PubMed

    García Aldrete, Alfonso N; González Obando, Ranulfo; Carrejo, Nancy S

    2013-01-01

    Two new related Colombian genera of Lachesillidae, including three new species, from the Department of Valle del Cauca, are here described and illustrated. They belong in the tribe Graphocaeciliini (Eolachesillinae). The new genera differ from the other genera in the tribe lacking ocelli, by characters of the male clunium, phallosome, endophallus, paraprocts, and female subgenital plate, gonapophyses and IX sternum. The types are deposited in the Entomological Museum of the Universidad del Valle (MUSENUV), in Santiago de Cali, Colombia.

  16. Defining the defect in F508 del CFTR: a soluble problem?

    PubMed

    Deber, Charles M; Cheung, Joanne C; Rath, Arianna

    2008-01-01

    Previously reported crystal structures of CFTR F508 del-NBD1 were determined in the presence of solubilizing mutations. In this issue of Chemistry & Biology, Pissarra et al. (2008) show that partial rescue of the trafficking and gating defects of full-length CFTR occurs in vivo upon recapitulation of the solubilizing F494N/Q637R or F428S/F494N/Q637R substitutions in cis with F508 del. PMID:18215767

  17. Large amplitude super-soft X-ray intensity variations and a 54 sec QPO in Nova Del 2013 (V339 Del)

    NASA Astrophysics Data System (ADS)

    Beardmore, A. P.; Osborne, J. P.; Page, K. L.

    2013-11-01

    In ATEL #5505 we reported the rise of the super-soft X-ray source in Nova Del 2013 (V339 Del) seen by the Swift XRT. Since the last observation reported there, at 1.5 c/s on day 70.8 after outburst, the soft X-ray count rate has risen to a peak count rate of ~100 c/s on day 87.9 (10 Nov). All count rates are from grade 0 events only. The rising count rate was interspersed by a few large dips, one of which reached down to <1% of the count rate one day earlier.

  18. Unravelling druggable signalling networks that control F508del-CFTR proteostasis

    PubMed Central

    Hegde, Ramanath Narayana; Parashuraman, Seetharaman; Capuani, Fabrizio; Carissimo, Annamaria; Carrella, Diego; Belcastro, Vincenzo; Subramanian, Advait; Bounti, Laura; Persico, Maria; Carlile, Graeme; Galietta, Luis; Thomas, David Y; Di Bernardo, Diego; Luini, Alberto

    2015-01-01

    Cystic fibrosis (CF) is caused by mutations in CF transmembrane conductance regulator (CFTR). The most frequent mutation (F508del-CFTR) results in altered proteostasis, that is, in the misfolding and intracellular degradation of the protein. The F508del-CFTR proteostasis machinery and its homeostatic regulation are well studied, while the question whether ‘classical’ signalling pathways and phosphorylation cascades might control proteostasis remains barely explored. Here, we have unravelled signalling cascades acting selectively on the F508del-CFTR folding-trafficking defects by analysing the mechanisms of action of F508del-CFTR proteostasis regulator drugs through an approach based on transcriptional profiling followed by deconvolution of their gene signatures. Targeting multiple components of these signalling pathways resulted in potent and specific correction of F508del-CFTR proteostasis and in synergy with pharmacochaperones. These results provide new insights into the physiology of cellular proteostasis and a rational basis for developing effective pharmacological correctors of the F508del-CFTR defect. DOI: http://dx.doi.org/10.7554/eLife.10365.001 PMID:26701908

  19. Unravelling druggable signalling networks that control F508del-CFTR proteostasis.

    PubMed

    Hegde, Ramanath Narayana; Parashuraman, Seetharaman; Iorio, Francesco; Ciciriello, Fabiana; Capuani, Fabrizio; Carissimo, Annamaria; Carrella, Diego; Belcastro, Vincenzo; Subramanian, Advait; Bounti, Laura; Persico, Maria; Carlile, Graeme; Galietta, Luis; Thomas, David Y; Di Bernardo, Diego; Luini, Alberto

    2015-01-01

    Cystic fibrosis (CF) is caused by mutations in CF transmembrane conductance regulator (CFTR). The most frequent mutation (F508del-CFTR) results in altered proteostasis, that is, in the misfolding and intracellular degradation of the protein. The F508del-CFTR proteostasis machinery and its homeostatic regulation are well studied, while the question whether 'classical' signalling pathways and phosphorylation cascades might control proteostasis remains barely explored. Here, we have unravelled signalling cascades acting selectively on the F508del-CFTR folding-trafficking defects by analysing the mechanisms of action of F508del-CFTR proteostasis regulator drugs through an approach based on transcriptional profiling followed by deconvolution of their gene signatures. Targeting multiple components of these signalling pathways resulted in potent and specific correction of F508del-CFTR proteostasis and in synergy with pharmacochaperones. These results provide new insights into the physiology of cellular proteostasis and a rational basis for developing effective pharmacological correctors of the F508del-CFTR defect. PMID:26701908

  20. Unravelling druggable signalling networks that control F508del-CFTR proteostasis.

    PubMed

    Hegde, Ramanath Narayana; Parashuraman, Seetharaman; Iorio, Francesco; Ciciriello, Fabiana; Capuani, Fabrizio; Carissimo, Annamaria; Carrella, Diego; Belcastro, Vincenzo; Subramanian, Advait; Bounti, Laura; Persico, Maria; Carlile, Graeme; Galietta, Luis; Thomas, David Y; Di Bernardo, Diego; Luini, Alberto

    2015-12-23

    Cystic fibrosis (CF) is caused by mutations in CF transmembrane conductance regulator (CFTR). The most frequent mutation (F508del-CFTR) results in altered proteostasis, that is, in the misfolding and intracellular degradation of the protein. The F508del-CFTR proteostasis machinery and its homeostatic regulation are well studied, while the question whether 'classical' signalling pathways and phosphorylation cascades might control proteostasis remains barely explored. Here, we have unravelled signalling cascades acting selectively on the F508del-CFTR folding-trafficking defects by analysing the mechanisms of action of F508del-CFTR proteostasis regulator drugs through an approach based on transcriptional profiling followed by deconvolution of their gene signatures. Targeting multiple components of these signalling pathways resulted in potent and specific correction of F508del-CFTR proteostasis and in synergy with pharmacochaperones. These results provide new insights into the physiology of cellular proteostasis and a rational basis for developing effective pharmacological correctors of the F508del-CFTR defect.

  1. MALARIA VECTORS IN SAN JOSÉDEL GUAVIARE, ORINOQUIA, COLOMBIA

    PubMed Central

    JIMÉNEZ, IRENE P.; CONN, JAN E.; BROCHERO, HELENA

    2015-01-01

    This study was conducted to determine Anopheles species composition and their natural infectivity by human Plasmodium in 2 localities with the highest malaria transmission in San Jose del Guaviare, Guaviare, Colombia. A total of 1,009 Anopheles mosquitoes were collected using human landing catches during 8 months in 2010. Anopheles darlingi was the most abundant (83.2%) followed by An. albitarsis s.l. (8.6%), Anopheles braziliensis (3.8%), An. oswaldoi s.l. (1%), and An. rangeli (0.3%). Anopheles darlingi showed the highest human biting rate, and it was found naturally infected with Plasmodium vivax VK210 (0.119%) using enzyme-linked immunosorbent assays. All species were collected biting both indoors and outdoors. Anopheles darlingi showed biting activity overnight with an indoor peak between 1200–0100 h. Therefore, we recommend that malaria prevention strategies focus on 1) insecticide-treated nets to reduce human–vector contact when people are most exposed and unprotected; 2) accurate diagnoses; 3) adequate treatment for patients; 4) more timely epidemiological notification; and 5) improved entomological surveillance. PMID:25102591

  2. Seismicity following the 1985 eruption of Nevado del Ruiz, Colombia

    USGS Publications Warehouse

    Zollweg, J.E.

    1990-01-01

    Over 200 of the best-recorded earthquakes occurring near Nevado del Ruiz, Colombia, between December 1985 and May 1986 are examined for spatial patterns, information on local stress orientations, and evidence for seismogenic structures that may be related to magma-transport processes. These earthquakes occurred following the devastating eruption of November 13, 1985. Earthquake activity that is probably related to the volcanic system occurs over a large area, of the order of 50 km2. A pattern of earthquakes beneath the southern half of Ruiz may be the expression of a conduit system, but evidence is inconclusive due to low spatial resolution of most hypocenters. Epicenter and first-motion plots suggest most earthquakes occur on small faults of varying orientation. Most seismicity during this time period was unrelated to mapped faults, including some with Holocene offsets, except for the Villamaria Fault near Ruiz's northeast sector. Composite focal mechanisms show a variation of nearly 90?? in the strike of T-axes and indicate Ruiz is in a zone of local extension. ?? 1990.

  3. ``Campo del Cielo'' Meteorites: Astronomical Heritage and Cultural Colonialism

    NASA Astrophysics Data System (ADS)

    López, Alejandro Martín; Altman, Agustina

    2012-09-01

    In the province of Chaco, Argentina, there is a very unique dispersion of metallic meteorites called ``Campo del Cielo''. One of the meteoric fragments of this dispersion, the meteorite called ``El Chaco'', consisting of 37 tons, is the second heaviest in the world. These meteorites are of great importance to the worldview of the Moqoit, aboriginal people that inhabit this region. For the local Creole population the meteorites are also relevant, that's why they have being cited in numerous documents and reports since the colonial period. During the first months of 2012, two Argentine artists and the Artistic Director of the German contemporary art exhibition called dOCUMENTA (13) tried to move ``El Chaco'' meteorite to Germany in order to exhibit it as an artistic object. Due to the fact that moving the meteorite could have a negative impact according to the Moqoit cosmology and that they were not able to participate in the decision they begun a manifestation against the movement of El Chaco. The opposition made by aboriginal communities and experts in cultural astronomy was able to stop the transfer. The whole process and its impact on the local community have promoted a deep discussion about art, science and cultural colonialism. In this paper we aim to address this debate and its consequences. This will allow us to think about contemporary forms of colonialism that are hidden in many scientific and artistic projects. Furthermore, we aim to debate about the most effective ways of protecting astronomical heritage in the Third World.

  4. El uso de la neuromodulación para el tratamiento del temblor

    PubMed Central

    Bendersky, Damián; Ajler, Pablo; Yampolsky, Claudio

    2014-01-01

    Introducción: El temblor puede ser un desorden incapacitante y el tratamiento de primera línea para estos pacientes es farmacológico. Sin embargo, este tratamiento puede llevar a una reducción satisfactoria del temblor en sólo el 50% de los pacientes con temblor esencial. La talamotomía era el tratamiento de elección para el temblor refractario al tratamiento médico hasta que comenzó a utilizarse la estimulación cerebral profunda (ECP) del núcleo ventral intermedio (Vim) del tálamo. En la actualidad, raramente se realiza la talamotomía. Métodos: Este artículo es una revisión no sistemática de las indicaciones, resultados, parámetros de programación y técnica quirúrgica de la ECP del Vim para el tratamiento del temblor. Resultados: Aunque los resultados clínicos son similares usando la talamotomía o la ECP del Vim, la primera causa más efectos adversos que la última. Además, la ECP puede ser usada bilateralmente, mientras que la talamotomía tiene un alto riesgo de causar disartria cuando se realiza de ambos lados. La ECP del Vim logró una adecuada mejoría del temblor en varias series de pacientes con temblor causado por temblor esencial, enfermedad de Parkinson o esclerosis múltiple. Además del Vim, hay otros blancos que están siendo usados por varios autores, tales como la zona incerta y las radiaciones prelemniscales. Conclusión: La ECP del Vim es un tratamiento útil para el temblor incapacitante refractario al tratamiento médico. Es esencial realizar una precisa selección de pacientes, así como utilizar una técnica quirúrgica correcta. Aún se desconoce el mejor blanco estereotáctico para el temblor, aunque el Vim es el más usado. PMID:25165613

  5. El equilibrio correcto: cómo ayudar a los supervivientes de cáncer a tener un peso saludable

    Cancer.gov

    Artículo sobre las intervenciones que buscan ayudar a los supervivientes a mantener un peso saludable para reducir la recidiva y la muerte por cáncer, y disminuir la probabilidad de padecer efectos tardíos y crónicos del tratamiento.

  6. Resistivity structure of the Del Mar methane seep.

    NASA Astrophysics Data System (ADS)

    Kannberg, P. K.; Constable, S.

    2015-12-01

    In March of 2015 we mapped the resistivity structure of the Del Mar methane seep in the inner California borderlands using a deep towed electromagnetic (EM) source and receiver array. Located in the San Diego trough at a depth of 1km, the seep site is on the flank of a mound associated with a transpressive step in the San Diego trough fault. The seep site has previously been associated with seafloor pockmarks, acoustic wipeouts, chemosynthetic communities, and active methane bubble venting. Controlled source electromagnetic (CSEM) surveys are performed by deep-towing an EM source that is transmitting a known signal; this signal is detected by towed receivers. This transmitted signal is altered by the electrical properties of the surrounding environment. Compared to seismic methods, EM methods are largely insensitive to free gas, making it an especially useful tool for detecting electrically resistive methane hydrate in areas of active gas venting. We used a 50m dipole transmitting 100A, with 3-axis electric field receivers spaced at 130m, 230m, 330m, and 430m behind the transmitter dipole center. The receiver data are inverted using MARE2DEM, a finite element 2D inversion routine. The inversion results show the background resistivity of the trough sediments to be about 1-2 ohmm, and are largely featureless outside of the seep site. However at the seep site we see a decanter-shaped 100 ohmm resistor whose base is 100m below the seafloor, and 1km wide at its widest. This feature narrows at the top to form a pipe structure about 200m wide that extends to the seafloor. These resistive structures are interpreted to be methane hydrate resulting from methane rich fluid flow along faults associated with the transpressional system that brackets the seep site.

  7. Predicting Nonspecific Ion Binding Using DelPhi

    PubMed Central

    Petukh, Marharyta; Zhenirovskyy, Maxim; Li, Chuan; Li, Lin; Wang, Lin; Alexov, Emil

    2012-01-01

    Ions are an important component of the cell and affect the corresponding biological macromolecules either via direct binding or as a screening ion cloud. Although some ion binding is highly specific and frequently associated with the function of the macromolecule, other ions bind to the protein surface nonspecifically, presumably because the electrostatic attraction is strong enough to immobilize them. Here, we test such a scenario and demonstrate that experimentally identified surface-bound ions are located at a potential that facilitates binding, which indicates that the major driving force is the electrostatics. Without taking into consideration geometrical factors and structural fluctuations, we show that ions tend to be bound onto the protein surface at positions with strong potential but with polarity opposite to that of the ion. This observation is used to develop a method that uses a DelPhi-calculated potential map in conjunction with an in-house-developed clustering algorithm to predict nonspecific ion-binding sites. Although this approach distinguishes only the polarity of the ions, and not their chemical nature, it can predict nonspecific binding of positively or negatively charged ions with acceptable accuracy. One can use the predictions in the Poisson-Boltzmann approach by placing explicit ions in the predicted positions, which in turn will reduce the magnitude of the local potential and extend the limits of the Poisson-Boltzmann equation. In addition, one can use this approach to place the desired number of ions before conducting molecular-dynamics simulations to neutralize the net charge of the protein, because it was shown to perform better than standard screened Coulomb canned routines, or to predict ion-binding sites in proteins. This latter is especially true for proteins that are involved in ion transport, because such ions are loosely bound and very difficult to detect experimentally. PMID:22735539

  8. Modelo semi-empírico de protuberancia solar a partir del diagnóstico de densidades

    NASA Astrophysics Data System (ADS)

    Cirigliano, D.; Vial, J. C.; Rovira, M.

    A partir de la observación del espectro del quintuplete de C III alrededor de 1175 Å, se ha realizado el diagnóstico de la densidad y presión electrónica, basado en el cálculo del cociente de las intensidades observadas. Una vez establecida la densidad electrónica, y con el cálculo de las velocidades Doppler, hemos investigado el flujo de masa en la protuberancia en función de la temperatura. Estableciendo como hipótesis la conservación del número de partículas que ingresan y salen del cuerpo de la protuberancia, se investiga la variación del área de un tubo de flujo semi-empírico en función de la temperatura. A partir de dicho diagnóstico, se examina el comportamiento del radio del tubo magnético en función de la temperatura, los que dan cuenta de la abertura de las líneas de campo magnético que confinan el plasma y de la divergencia del campo magnético en diferentes alturas de la atmósfera solar.

  9. La implantacion del enfoque constructivista en el aula de ciencia: Estudio de caso multiple

    NASA Astrophysics Data System (ADS)

    Arroyo Betancourt, Luz I.

    Esta investigacion estudia la implantacion del enfoque constructivista en tres aulas de ciencia del contexto puertorriqueno. Se auscultaron las practicas educativas que utilizan maestras consideradas constructivistas y la correspondencia de sus practicas educativas con los elementos esenciales de la didactica que proponen los teoricos de los planteamientos constructivistas. Se ausculto, ademas, a que vision del enfoque constructivista responden las expresiones de las maestras acerca de su practica educativa y como compara con su quehacer, a la luz de los elementos esenciales de las visiones constructivistas piagetiana, social y radical. Se utilizo el diseno de estudio descriptivo de caso multiple. El estudio se baso en entrevistas a profundidad, revision de documentos y observacion no participativa a la sala de clases. El contexto fueron tres escuelas publicas de la Region Educativa de San Juan, una elemental, una intermedia y una superior. Los resultados confirmaron que la transicion hacia el enfoque constructivista es un proceso que toma tiempo, dedicacion y la participacion en adiestramientos y readiestramientos acerca del nuevo enfoque. Las maestras coinciden en la mayoria de las practicas educativas que utilizan para implantar el enfoque constructivista de ensenanza y difieren en algunas debido, probablemente, a que han tenido que adaptarlas a los correspondientes niveles de ensenanza: elemental, intermedio y superior. Dos de las maestras planifican por conceptos generadores, mientras que una de ellas planifica siguiendo la guia que recibe del Departamento de Educacion. Difieren ademas, en el enfasis que confieren al inquirir cientifico. Con relacion a la correspondencia entre la vision manifestada por las maestras a la luz de las visiones piagetiana, social y radical, aparentemente, las preguntas del protocolo de entrevistas no lograron evocar la informacion con suficiente profundidad, por lo que la investigadora tuvo que inferir las visiones de las

  10. Detecting a hierarchical genetic population structure via Multi-InDel markers on the X chromosome.

    PubMed

    Fan, Guang Yao; Ye, Yi; Hou, Yi Ping

    2016-01-01

    Detecting population structure and estimating individual biogeographical ancestry are very important in population genetics studies, biomedical research and forensics. Single-nucleotide polymorphism (SNP) has long been considered to be a primary ancestry-informative marker (AIM), but it is constrained by complex and time-consuming genotyping protocols. Following up on our previous study, we propose that a multi-insertion-deletion polymorphism (Multi-InDel) with multiple haplotypes can be useful in ancestry inference and hierarchical genetic population structures. A validation study for the X chromosome Multi-InDel marker (X-Multi-InDel) as a novel AIM was conducted. Genetic polymorphisms and genetic distances among three Chinese populations and 14 worldwide populations obtained from the 1000 Genomes database were analyzed. A Bayesian clustering method (STRUCTURE) was used to discern the continental origins of Europe, East Asia, and Africa. A minimal panel of ten X-Multi-InDels was verified to be sufficient to distinguish human ancestries from three major continental regions with nearly the same efficiency of the earlier panel with 21 insertion-deletion AIMs. Along with the development of more X-Multi-InDels, an approach using this novel marker has the potential for broad applicability as a cost-effective tool toward more accurate determinations of individual biogeographical ancestry and population stratification. PMID:27535707

  11. The RGD finger of Del-1 is a unique structural feature critical for integrin binding

    SciTech Connect

    Schürpf, Thomas; Chen, Qiang; Liu, Jin-huan; Wang, Rui; Springer, Timothy A.; Wang, Jia-huai

    2012-11-13

    Developmental endothelial cell locus-1 (Del-1) glycoprotein is secreted by endothelial cells and a subset of macrophages. Del-1 plays a regulatory role in vascular remodeling and functions in innate immunity through interaction with integrin {alpha}{sub V}{beta}{sub 3}. Del-1 contains 3 epidermal growth factor (EGF)-like repeats and 2 discoidin-like domains. An Arg-Gly-Asp (RGD) motif in the second EGF domain (EGF2) mediates adhesion by endothelial cells and phagocytes. We report the crystal structure of its 3 EGF domains. The RGD motif of EGF2 forms a type II' {beta} turn at the tip of a long protruding loop, dubbed the RGD finger. Whereas EGF2 and EGF3 constitute a rigid rod via an interdomain calcium ion binding site, the long linker between EGF1 and EGF2 lends considerable flexibility to EGF1. Two unique O-linked glycans and 1 N-linked glycan locate to the opposite side of EGF2 from the RGD motif. These structural features favor integrin binding of the RGD finger. Mutagenesis data confirm the importance of having the RGD motif at the tip of the RGD finger. A database search for EGF domain sequences shows that this RGD finger is likely an evolutionary insertion and unique to the EGF domain of Del-1 and its homologue milk fat globule-EGF 8. The RGD finger of Del-1 is a unique structural feature critical for integrin binding.

  12. Detecting a hierarchical genetic population structure via Multi-InDel markers on the X chromosome

    PubMed Central

    Fan, Guang Yao; Ye, Yi; Hou, Yi Ping

    2016-01-01

    Detecting population structure and estimating individual biogeographical ancestry are very important in population genetics studies, biomedical research and forensics. Single-nucleotide polymorphism (SNP) has long been considered to be a primary ancestry-informative marker (AIM), but it is constrained by complex and time-consuming genotyping protocols. Following up on our previous study, we propose that a multi-insertion-deletion polymorphism (Multi-InDel) with multiple haplotypes can be useful in ancestry inference and hierarchical genetic population structures. A validation study for the X chromosome Multi-InDel marker (X-Multi-InDel) as a novel AIM was conducted. Genetic polymorphisms and genetic distances among three Chinese populations and 14 worldwide populations obtained from the 1000 Genomes database were analyzed. A Bayesian clustering method (STRUCTURE) was used to discern the continental origins of Europe, East Asia, and Africa. A minimal panel of ten X-Multi-InDels was verified to be sufficient to distinguish human ancestries from three major continental regions with nearly the same efficiency of the earlier panel with 21 insertion-deletion AIMs. Along with the development of more X-Multi-InDels, an approach using this novel marker has the potential for broad applicability as a cost-effective tool toward more accurate determinations of individual biogeographical ancestry and population stratification. PMID:27535707

  13. Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis

    PubMed Central

    Wang, Zhen; Tran, Misha C.; Bhatia, Namrata J.; Hsing, Alexander W.; Chen, Carol; LaRussa, Marie F.; Fattakhov, Ernst; Rashidi, Vania; Jang, Kyu Yun; Choo, Kevin J.; Nie, Xingju; Mathy, Jonathan A.; Longaker, Michael T.; Dauskardt, Reinhold H.; Helms, Jill A.; Yang, George P.

    2016-01-01

    Objective We identified significant expression of the matricellular protein, DEL1, in hypertrophic and mature cartilage during development. We hypothesized that this tissue-specific expression indicated a biological role for DEL1 in cartilage biology. Methods Del1 KO and WT mice had cartilage thickness evaluated by histomorphometry. Additional mice underwent medial meniscectomy to induce osteoarthritis, and were assayed at 1 week for apoptosis by TUNEL staining and at 8 weeks for histology and OA scoring. In vitro proliferation and apoptosis assays were performed on primary chondrocytes. Results Deletion of the Del1 gene led to decreased amounts of cartilage in the ears and knee joints in mice with otherwise normal skeletal morphology. Destabilization of the knee led to more severe OA compared to controls. In vitro, DEL1 blocked apoptosis in chondrocytes. Conclusion Osteoarthritis is among the most prevalent diseases worldwide and increasing in incidence as our population ages. Initiation begins with an injury resulting in the release of inflammatory mediators. Excessive production of inflammatory mediators results in apoptosis of chondrocytes. Because of the limited ability of chondrocytes to regenerate, articular cartilage deteriorates leading to the clinical symptoms including severe pain and decreased mobility. No treatments effectively block the progression of OA. We propose that direct modulation of chondrocyte apoptosis is a key variable in the etiology of OA, and therapies aimed at preventing this important step represent a new class of regenerative medicine targets. PMID:27505251

  14. High mountain soils and periglacial features at the Torres del Paine, National Park Torres del Paine, Chile.

    NASA Astrophysics Data System (ADS)

    Senra, Eduardo; Schaefer, Carlos; Simas, Felipe; Gjorup, Davi

    2015-04-01

    The Torres del Paine National Park (TPNP) is located on the southern limit of the Andean Southern Ice Field, part of the Magallanes and Antartica Chilena region, in the province of Ultima Esperanza. The TPNP has a very heterogeneous climate due to orographic influence and wet air masses from the Pacific. The geology is basically Cretaceous metasedimentary rocks and Miocene granitic plutons and batholiths. We studied the main soils and geoenvironments of Mt Ferrier mountain and its surroundings, based on soils , landforms and vegetation aspects. The geoenvironmental stratification was based on the combined variation and integration of pedo-litho-geomorphological features with the vegetation. WE used detailed geological maps, a DEM and slope maps and WorlView II satellite images. Fifteen soils profiles were sampled and classified according to Soil Taxonomy (2010) at all genovironments, ranging from 50 m a.s.l to the at high plateau just below the permanent snowline, under periglacial conditions (~1004m asl). Three soil temperature and moisture monitoring sites were set, allowing for 24 consecutive months (2011 to 2013). Seven geoenvironments were identified with distinct soil and landform characteristics, all with a similar geological substrate. The landform and vegetation have a strong connection with the landscape dynamic, controlling erosional and depositional processes, resulting from glacier advances and retreats in the Late Quaternary. Wind blown materials is widespread, in the form of loess material, accumulating in the higher parts of the landscape. On the other hand, accumulation of organic matter in the water-saturated depressions is common in all altitudes. Generally the soils are acidic and dystrophic, with little exceptions. The following geoenvironments were identified: Periglacial Tundra, Loess slopes, Talus and scarpmentd, Fluvio-glacial terraces, Fluvio-lacustrine plains, Moraines and Paleodunes. The regional pedology show the occurrence of five soil

  15. The Astronomy Club of Araranguá: Educating Science Teachers as Science Communicators. (Breton Title: Clube de Astronomia de AraranguÁ: a Formação de Professores de Ciências Como Divulgadores Científicos. ) Club de Astronomía de Araranguá: la Formación del Profesorado Como Comunicadores de la Ciencia

    NASA Astrophysics Data System (ADS)

    Damasio, Felipe; Allain, Olivier; Antunes Rodrigues, Adriano

    2013-07-01

    -se na Teoria da Aprendizagem Significativa, sempre procurando alcançar a pré-disposição em aprender e produzir material potencialmente significativo, as duas condições necessárias para que a aprendizagem significativa ocorra. El estudio relatado en este trabajo se lleva a cabo desde 2009 en el Instituto Federal de Educação, Ciência e Tecnología de Santa Catarina, campus Araranguá. En él se busca formar a comunicadores de la ciencia durante la formación inicial de los docentes Licenciatura en Ciencias Naturales con especialidad en Física, y también promover acciones de divulgación científica para el público en general en la región de Araranguá a través de un club de astronomía llamado CA2 (Clube de Astronomia Araranguá). Entres las acciones de los estudiantes que se promueven están: producción de videos, programas de radio, conferencias, observaciones nocturnas, la preparación y exposición de carteles, la educación en física para los niños, actividades de formación permanente del profesorado y enseñanza de la física de con el tema generador Astronomía. El trabajo de la formación del profesorado y la difusión de club científico se basa en la teoría del aprendizaje significativo, buscando siempre la predisposición para aprender y producir material potencialmente significativo, las dos condiciones necesarias para que ocurra el aprendizaje significativo.

  16. Mejoras en el apuntado del telescopio de 2,15 mts de CASLEO

    NASA Astrophysics Data System (ADS)

    Aballay, J. L.; Casagrande, A. R.; Pereyra, P. F.; Marún, A. H.

    Con el objeto de optimizar el funcionamiento del telescopio de 2,15 mts. de CASLEO, se están eliminando los motores de calar, de guía y mecánica asociada. Para ésto, se están diseñando dos electrónicas que gobernarán, solamente, el motor de slew y el de tracking. Con el control del motor de slew se realizarán las funciones de slew y calar, controlando desde una PC la placa que maneja las rampas de velocidad. De este modo, el movimiento será programado y por lo tanto, más suave y preciso. Con el control del motor de tracking, a través de un generador de frecuencias programable desde una PC, se proveerá los movimientos necesarios para el tracking y guía.

  17. Biotic association and palaeoenvironmental reconstruction of the "Loma del Pterodaustro" fossil site (Early Cretaceous, Argentina)

    USGS Publications Warehouse

    Chiappe, L.; Rivarola, D.; Cione, A.; Fregenal-Martinez, M.; Sozzi, H.; Buatois, L.; Gallego, O.; Laza, J.; Romero, E.; Lopez-Arbarello, A.; Buscalioni, A.; Marsicano, C.; Adamonis, S.; Ortega, F.; McGehee, S.; Di, Iorio O.

    1998-01-01

    A sedimentological analysis of the basal section of the Early Cretaceous, lacustrine Lagarcito Formation at "Loma del Pterodaustro" (San Luis, Argentina) and a summary of its biological components are presented. Three sedimentological facies can be recognized in the basal sequence of the Lagarcito Formation. Fossil remains are particularly abundant in laminated claystones of a facies interpreted as deposits formed in offshore areas of the lake. The preservation of delicate structures allows recognition of these deposits as a Konservat Lagersta??tte. Up to now, rocks at "Loma del Pterodaustro" have yielded plants, conchostracans, semionotid and pleuropholid fishes, pterodactyloid pterosaurs, and a variety of invertebrate traces. The chronology of the Lagarcito Formation is discussed and it is concluded that this unit is of Albian age. The palaeoenvironment of deposition of the basal sequence of the Lagarcito Formation at "Loma del Pterodaustro" is interpreted as a perennial, shallow lake developed within an alluvial plain, under semiarid climatic conditions.

  18. Ectopsocidae (Psocodea: 'Psocoptera') from Valle del Cauca and NNP Gorgona, Colombia.

    PubMed

    Manchola, Oscar Fernando Saenz; Obando, Ranulfo González; Aldrete, Alfonso N García

    2014-04-14

    The results of a survey of the psocid family Ectopsocidae in Valle del Cauca and NNP Gorgona, are here presented. Fifteen species were identified, in the genera Ectopsocus (14 species), and Ectopsocopsis (one species); four of the Ectopsocus species are new to science and are here described and illustrated. The male of E. thorntoni García Aldrete is here described. Records of Ectopsocopsis cryptomeriae (Enderlein), Ectopsocus briggsi McLachlan, E. californicus Banks, E. columbianus Badonnel, E. maindroni Badonnel, E. meridionalis Ribaga, E. pilosus Badonnel, E. richardsi Pearman, E. titschacki Jentsch, and E. vilhenai Badonnel, are provided. Ten species were found only in Valle del Cauca, two species were found only in the NNP Gorgona, and three species were found at both sites. The specimens studied are deposited in the Entomological Museum, Universidad del Valle, Santiago de Cali, Colombia (MUSENUV).

  19. La relatività debole. La fisica dello spazio e del tempo senza paradossi

    NASA Astrophysics Data System (ADS)

    Selleri, Franco

    2011-06-01

    Secondo Einstein e Poincaré la simultaneità di eventi che hanno luogo in punti diversi dello spazio può essere definita solo per convenzione. Dal punto di vista matematico si dimostra, quindi, che due diverse definizioni di simultaneità corrispondono a due diversi valori del coefficiente e1 della variabile spaziale x presente nelle trasformazioni di Lorentz. A partire da premesse normalmente accettate otterremo diverse dimostrazioni della necessità di reintrodurre il concetto di simultaneità assoluta. Le conseguenze cosmologiche della nuova struttura dello spazio e del tempo andranno contro la cosmologia del Big Bang. Inoltre, dopo questi risultati, il relativismo sopravviverà in una forma meno aspra ("relatività debole") perché risulter privo di quel campionario di paradossi portato dalla teoria della Relatività Speciale.

  20. Integrated global background monitoring network. Preliminary results from Torres del Paine and Olympic National Parks

    SciTech Connect

    Wiersma, G.B.; Kohler, A.; Boelcke, C.; Baker, G.; Harmon, M.; Weber, C.; Gonzales, J.

    1985-10-01

    During 1984, a pilot project was initiated for monitoring pollution at Torres del Paine National Park in southern Chile and Olympic National Park in the United States. These are two of three initial sites that are to be established as part of an integrated global backgound monitoring network. Eventually, the plan is to establish a world-wide system of such sites. We collected and analyzed samples of the soil, water, air, and two species of plants (moss and lichen). We also collected and analyzed samples of the forest litter. We compared the samples of soil and vegetation against reference samples. We also compared samples of soil, vegetation, and of organic material from Torres del Paine against similar samples from Olympic and Sequoia-Kings Canyon National Parks in the United States. Although the data is preliminary, it is in agreement with out initial hypothesis that Torres del Paine and Olympic National Parks are not a polluted sites.

  1. CASE REPORT: Phenotypic presentation of the Ser63Del MPZ mutation

    PubMed Central

    Miller, Lindsey J.; Patzko, Agnes; Lewis, Richard A.; Shy, Michael E.

    2013-01-01

    Mutations in MPZ cause CMT1B, the second most frequent cause of CMT1. Elegant studies with Ser63del mice suggest that Ser63del MPZ is retained in the ER where it activates the unfolded protein response (UPR) that contributes to the neuropathy. Clinical information about patients with this mutation is limited. We present clinical and electrophysiological data on a large multigenerational family with CMT1B caused by Ser63del MPZ. The patients have a classical CMT1 phenotype that is much less severe than that of patients with Arg98Cys MPZ that also activates the UPR. These results suggest that clinical presentation along cannot predict which MPZ mutations will be retained in the ER and activate the UPR. PMID:22734905

  2. L'eliosismologia: onde sismiche per studiare l'interno del Sole

    NASA Astrophysics Data System (ADS)

    Di Mauro, M. P.

    2014-12-01

    Negli ultimi cinquanta anni siamo stati testimoni di una straordinaria rivoluzione della conoscenza e comprensione della nostra stella grazie alla nascita dell'Eliosismologia, lo studio delle oscillazioni solari. Analogamente a ciò che accade nella Terra durante i terremoti, anche l'interno del Sole è pervaso continuamente da onde sismiche che provocano piccole oscillazioni, ovvero deformazioni della fotosfera. Le oscillazioni sono la manifestazione di diversi processi che avvengono all'interno della struttura del Sole e le frequenze sismiche dei modi osservati e misurati sulla superficie sono legate direttamente ai parametri fisici degli strati interni attraversati dalle onde sismiche. Lo studio delle oscillazioni rappresenta, quindi, l'unico metodo diretto per studiare la struttura e la dinamica interna del Sole. In questo articolo verranno illustrate le caratteristiche generali delle oscillazioni solari e verranno presentati i risultati importanti e i progressi notevoli raggiunti grazie all'Eliosismologia.

  3. Trichomycetes living in the guts of aquatic insects of Misiones and Tierra del Fuego, Argentina.

    PubMed

    López Lastra, Claudia C; Scorsetti, Ana C; Marti, Gerardo A; Coscarón, Sixto

    2005-01-01

    Fourteen species of Trichomycetes living in the guts of aquatic insects are reported from two provinces of Argentina, Misiones and Tierra del Fuego. Twelve of the species belong to the Harpellales and two are Amoebidiales. Five harpellid species are reported from Misiones in the extreme northeast of the country (Genistellospora homothallica, Harpella tica, Smittium culisetae, Smittium sp., Stachylina sp.) and seven are from Tierra del Fuego, the southern tip of South America (H. meridianalis, Glotzia sp., S. culicis, S. cellaspora, S. imitatum, Stachylina minima, Penella simulii). Insect hosts all were immature stages of Culicidae, Simuliidae, Chironomidae, Ceratopogonidae (Insecta: Diptera), and Ephemeroptera and Plecoptera. The lower diversity of Trichomycetes found at Misiones, which has a subtropical climate and rainforest vegetation, was due possibly to the warmer temperatures of the water (15-24 C), compared to the colder streams of Tierra del Fuego (9-15 C), with forests and steppes as typical vegetation.

  4. Ectopsocidae (Psocodea: 'Psocoptera') from Valle del Cauca and NNP Gorgona, Colombia.

    PubMed

    Manchola, Oscar Fernando Saenz; Obando, Ranulfo González; Aldrete, Alfonso N García

    2014-01-01

    The results of a survey of the psocid family Ectopsocidae in Valle del Cauca and NNP Gorgona, are here presented. Fifteen species were identified, in the genera Ectopsocus (14 species), and Ectopsocopsis (one species); four of the Ectopsocus species are new to science and are here described and illustrated. The male of E. thorntoni García Aldrete is here described. Records of Ectopsocopsis cryptomeriae (Enderlein), Ectopsocus briggsi McLachlan, E. californicus Banks, E. columbianus Badonnel, E. maindroni Badonnel, E. meridionalis Ribaga, E. pilosus Badonnel, E. richardsi Pearman, E. titschacki Jentsch, and E. vilhenai Badonnel, are provided. Ten species were found only in Valle del Cauca, two species were found only in the NNP Gorgona, and three species were found at both sites. The specimens studied are deposited in the Entomological Museum, Universidad del Valle, Santiago de Cali, Colombia (MUSENUV). PMID:24869552

  5. [Hemorrhagic colloid cyst of the third ventricle: fulminant deterioration].

    PubMed

    Martínez-Gómez, Debora; Joanes, Vicente; Herrera, Juan Manuel; Rivera-Paz, Marlon; Vanaclocha, Vicente

    2015-03-16

    Introduccion. Los quistes coloides son tumores benignos del tercer ventriculo. La mayoria permanecen asintomaticos. Sin embargo, algunos pacientes pueden desarrollar desde cefaleas intermitentes hasta un deterioro agudo e incluso muerte subita. Existen varias teorias por las que se produciria una muerte subita en estos pacientes, entre las que se incluyen el rapido crecimiento del quiste, su rotura, la alteracion del control cardiovascular reflejo mediado por el hipotalamo y, rara vez, el sangrado del quiste, con solo 15 casos descritos en la bibliografia. Caso clinico. Varon de 45 años, con hipertension arterial como unico antecedente de interes, que sufre un deterioro brusco del nivel de consciencia a causa de una hidrocefalia aguda debida a un quiste coloide hemorragico del tercer ventriculo. Se implanto un drenaje ventricular externo en cada lado e ingreso en la unidad de cuidados intensivos, donde se certifico la muerte encefalica. Tras la extirpacion del quiste mediante abordaje transcortical frontal, se confirmo el diagnostico de quiste coloide con restos de material hemolizado subagudo. Conclusion. La hemorragia en los quistes coloides es excepcional y puede producirse en pacientes tanto sintomaticos como asintomaticos, lo que dificulta, de forma extraordinaria, el reconocimiento de esta complicacion.

  6. Development and Utilization of InDel Markers to Identify Peanut (Arachis hypogaea) Disease Resistance.

    PubMed

    Liu, Lifeng; Dang, Phat M; Chen, Charles Y

    2015-01-01

    Peanut diseases, such as leaf spot and spotted wilt caused by Tomato Spotted Wilt Virus, can significantly reduce yield and quality. Application of marker assisted plant breeding requires the development and validation of different types of DNA molecular markers. Nearly 10,000 SSR-based molecular markers have been identified by various research groups around the world, but less than 14.5% showed polymorphism in peanut and only 6.4% have been mapped. Low levels of polymorphism limit the application of marker assisted selection (MAS) in peanut breeding programs. Insertion/deletion (InDel) markers have been reported to be more polymorphic than SSRs in some crops. The goals of this study were to identify novel InDel markers and to evaluate the potential use in peanut breeding. Forty-eight InDel markers were developed from conserved sequences of functional genes and tested in a diverse panel of 118 accessions covering six botanical types of cultivated peanut, of which 104 were from the U.S. mini-core. Results showed that 16 InDel markers were polymorphic with polymorphic information content (PIC) among InDels ranged from 0.017 to 0.660. With respect to botanical types, PICs varied from 0.176 for fastigiata var., 0.181 for hypogaea var., 0.306 for vulgaris var., 0.534 for aequatoriana var., 0.556 for peruviana var., to 0.660 for hirsuta var., implying that aequatoriana var., peruviana var., and hirsuta var. have higher genetic diversity than the other types and provide a basis for gene functional studies. Single marker analysis was conducted to associate specific marker to disease resistant traits. Five InDels from functional genes were identified to be significantly correlated to tomato spotted wilt virus (TSWV) infection and leaf spot, and these novel markers will be utilized to identify disease resistant genotype in breeding populations.

  7. Origin and distribution of the BRCA2-8765delAG mutation in breast cancer

    PubMed Central

    Palomba, Grazia; Cossu, Antonio; Friedman, Eitan; Budroni, Mario; Farris, Antonio; Contu, Antonio; Pisano, Marina; Baldinu, Paola; Sini, Maria C; Tanda, Francesco; Palmieri, Giuseppe

    2007-01-01

    Background The BRCA2-8765delAG mutation was firstly described in breast cancer families from French-Canadian and Jewish-Yemenite populations; it was then reported as a founder mutation in Sardinian families. We evaluated both the prevalence of the BRCA2-8765delAG variant in Sardinia and the putative existence of a common ancestral origin through a haplotype analysis of breast cancer family members carrying such a mutation. Methods Eight polymorphic microsatellite markers (D13S1250, centromeric, to D13S267, telomeric) spanning the BRCA2 gene locus were used for the haplotype analysis. Screening for the 8765delAG mutation was performed by PCR-based amplification of BRCA2-exon 20, followed by automated sequencing. Results Among families with high recurrence of breast cancer (≥ 3 cases in first-degree relatives), those from North Sardinia shared the same haplotype whereas the families from French Canadian and Jewish-Yemenite populations presented distinct genetic assets at the BRCA2 locus. Screening for the BRCA2-8765delAG variant among unselected and consecutively-collected breast cancer patients originating from the entire Sardinia revealed that such a mutation is present in the northern part of the island only [9/648 (1.4%) among cases from North Sardinia versus 0/493 among cases from South Sardinia]. Conclusion The BRCA2-8765delAG has an independent origin in geographically and ethnically distinct populations, acting as a founder mutation in North but not in South Sardinia. Since BRCA2-8765delAG occurs within a triplet repeat sequence of AGAGAG, our study further confirmed the existence of a mutational hot-spot at this genomic position (additional genetic factors within each single population might be involved in generating such a mutation). PMID:17640379

  8. Development and Utilization of InDel Markers to Identify Peanut (Arachis hypogaea) Disease Resistance

    PubMed Central

    Liu, Lifeng; Dang, Phat M.; Chen, Charles Y.

    2015-01-01

    Peanut diseases, such as leaf spot and spotted wilt caused by Tomato Spotted Wilt Virus, can significantly reduce yield and quality. Application of marker assisted plant breeding requires the development and validation of different types of DNA molecular markers. Nearly 10,000 SSR-based molecular markers have been identified by various research groups around the world, but less than 14.5% showed polymorphism in peanut and only 6.4% have been mapped. Low levels of polymorphism limit the application of marker assisted selection (MAS) in peanut breeding programs. Insertion/deletion (InDel) markers have been reported to be more polymorphic than SSRs in some crops. The goals of this study were to identify novel InDel markers and to evaluate the potential use in peanut breeding. Forty-eight InDel markers were developed from conserved sequences of functional genes and tested in a diverse panel of 118 accessions covering six botanical types of cultivated peanut, of which 104 were from the U.S. mini-core. Results showed that 16 InDel markers were polymorphic with polymorphic information content (PIC) among InDels ranged from 0.017 to 0.660. With respect to botanical types, PICs varied from 0.176 for fastigiata var., 0.181 for hypogaea var., 0.306 for vulgaris var., 0.534 for aequatoriana var., 0.556 for peruviana var., to 0.660 for hirsuta var., implying that aequatoriana var., peruviana var., and hirsuta var. have higher genetic diversity than the other types and provide a basis for gene functional studies. Single marker analysis was conducted to associate specific marker to disease resistant traits. Five InDels from functional genes were identified to be significantly correlated to tomato spotted wilt virus (TSWV) infection and leaf spot, and these novel markers will be utilized to identify disease resistant genotype in breeding populations. PMID:26617627

  9. Epidemiological surveillance of ovine hydatidosis in Tierra del Fuego, Patagonia Argentina, 1997-1999.

    PubMed

    Zanini, Fabián; Gonzalo, Roberto; Pérez, Héctor; Aparici, Inés; Soto, Ximena; Guerrero, Juvenal; Cerrone, Gloria; Elissondo, Celina

    2006-06-15

    Cystic echinococcosis is the most prevalent zoonosis in Tierra del Fuego province, Argentina, with important economic, productive and public health consequences. The present work was performed to determine the ovine prevalence in Tierra del Fuego, Argentina, as well as to evaluate the quality of diagnostic systems in slaughterhouses. Moreover, genetic analyses to characterize the strain of Echinococcus granulosus involved in the region were done. The first actions to perform a diagnosis of the epidemiological situation of hydatidosis in Tierra del Fuego were done between 1976 and 1977. A canine prevalence of 80% and an ovine prevalence of 55% results were obtained. Since 1979 the control program of Hydatidosis of Tierra del Fuego was implemented. It was based on semiannual canine anthelmintic treatment with praziquantel at dose of 5mg/kg, and complemented with sanitary education and canine and ovine epidemiological surveillance. During May 1997-January 1999: 5,916 sheep coming from 20 farms of the programmatic area were evaluated. In the lamb category, hydatid cysts were not found. In the adults category, 62 infected animals were found (3.2%). The ovine prevalence was 1.1% and there was 100% of coincidence between diagnosis in the slaughterhouse, re-inspection in the laboratory and histopathological study. The marked decrease in the prevalence observed for sheep infection evidenced a destabilization of the biological cycle of the parasite. This could be explained by the application of a control program with uninterrupted systematic actions. Polymerase chain reaction-ribosomal ITS-1 DNA (rDNA) restriction fragment length polymorphism (PCR-RFLP) analysis and partial sequencing of the mitochondrial cytochrome c oxidase subunit 1 (CO1) gene were used to characterize E. granulosus isolates collected from different regions of Tierra del Fuego to determine which genotypes occurred in this region. The results revealed the presence of the G1 genotype (sheep-dog strain

  10. A review on Balanites aegyptiaca Del (desert date): phytochemical constituents, traditional uses, and pharmacological activity

    PubMed Central

    Chothani, Daya L.; Vaghasiya, H. U.

    2011-01-01

    Balanites aegyptiaca Del. (Zygophyllaceae), known as ‘desert date,’ is spiny shrub or tree up to l0 m tall, widely distributed in dry land areas of Africa and South Asia. It is traditionally used in treatment of various ailments i.e. jaundice, intestinal worm infection, wounds, malaria, syphilis, epilepsy, dysentery, constipation, diarrhea, hemorrhoid, stomach aches, asthma, and fever. It contains protein, lipid, carbohydrate, alkaloid, saponin, flavonoid, and organic acid. Present review summarizes the traditional claims, phytochemistry, and pharmacology of B. aegyptiaca Del reported in scientific literature. PMID:22096319

  11. Detection of filaggrin gene mutation (2282del4) in Pakistani Ichthyosis vulgaris families.

    PubMed

    Naz, Naghma; Samdani, Azam Jah

    2011-06-01

    The aim of this study was to detect an 811 bp filaggrin (FLG) gene fragment known to carry a mutation 2282del4 which causes ichthyosis vulgaris. Seven clinically examined ichthyosis vulgaris families were included in this study. An 811 bp FLG gene fragment was targeted in the genomic DNA of all the members of the seven families by PCR amplification using known primers RPT1P7 and RPT2P1. Successful amplification of an 811 bp FLG gene fragment in all the families suggested the possible role of the 2282del4 mutation in causing ichthyosis vulgaris in Pakistani population.

  12. Archivo de placas astrométricas del Observatorio de La Plata

    NASA Astrophysics Data System (ADS)

    di Sisto, R.; Orellana, R. B.

    Se ha realizado una base de datos con las placas fotográficas obtenidas con el Astrográfico del Observatorio de La Plata. Se han clasificado un total de 3000 placas obtenidas para asteroides y cometas. El acceso a la base de datos se hará por FTP y la misma contendrá la siguiente información: fecha y tiempo de exposición, coordenadas del centro de placa, tipo de emulsión fotográfica, estado de la placa, objeto fotografiado.

  13. Black hole remnant and quantum tunnelling in three-dimensional Gödel spacetime

    NASA Astrophysics Data System (ADS)

    Li, Hui-Ling; Zu, Xiao-Tao

    2015-05-01

    Using the modified Dirac equation in a three-dimensional gravity background, we investigate the quantum correction to tunnelling radiation from a Gödel black hole, and discuss the black hole remnant employing fermion's tunnelling. The corrected tunnelling probability is derived, and the modified Hawking temperature is found as well. It is worth emphasizing that, only when the condition j> αω(3 r -- r +) is satisfied, emitting both a mass particle and a massless particle, the remnant of the Gödel black hole may arise.

  14. DELIVERING TIMELY AIR QUALITY, TRAFFIC, AND WEATHER INFORMATION TO YOUR COMMUNITY/THE PASO DEL NORTE ENVIRONMENTAL MONITORING PROJECT

    EPA Science Inventory

    EPA has developed a technology transfer handbook for the EMPACT Paso del Norte Project. The EMPACT Paso del Norte Environmental Monitoring Project is a mobile vehicle emissions project that involves the international community of El Paso, TX; Sundland Park, NM; and Juarez, Mexico...

  15. 33 CFR 207.100 - Inland waterway from Delaware River to Chesapeake Bay, Del. and Md. (Chesapeake and Delaware...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... River to Chesapeake Bay, Del. and Md. (Chesapeake and Delaware Canal); use, administration, and... Chesapeake Bay, Del. and Md. (Chesapeake and Delaware Canal); use, administration, and navigation. (a... regulations and monitor traffic through the canal. (c) Safe navigation required. Clearance for any vessel...

  16. 75 FR 44720 - Safety Zone; Live-Fire Gun Exercise, M/V Del Monte, James River, VA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-29

    ... SECURITY Coast Guard 33 CFR Part 165 RIN 1625-AA00 Safety Zone; Live-Fire Gun Exercise, M/V Del Monte... specified waters of the James River to protect mariners from the hazards associated with live fire and... conduct a live fire and explosive training event onboard the M/V Del Monte in the vicinity of the...

  17. Resultado negativo de prueba del VPH es mejor predictor de riesgo bajo de cáncer de cuello uterino

    Cancer.gov

    De acuerdo con un estudio en el que participaron más de un millón de mujeres, los investigadores del NCI han determinado que el resultado negativo de una prueba para la detección del VPH proporciona mayor certeza o seguridad frente a riesgos futuros de cá

  18. [Kidney transplant program at the Instituto Nacional de Cardiologia Ignacio Chavez].

    PubMed

    Mancilla-Urrea, Eduardo; Aburto-Morales, Salvador; Kasep-Bahena, Jorge; Rodríguez-Castellanos, Francisco

    2011-09-01

    The first renal transplant was done on July 22, 1968 and until December, 2010 a total of 865 procedures have been performed. Immunosuppressive protocols have changing with time: from 1968 to 1984 azathioprine + prednisone plus total radiation in some cases; from 1985 to 1998 cyclosporine + azathioprine + prednisone; in 1998 tacrolimus is used for first time; Mofetil micofenolate was available at 2005 and practically has displaced to azathioprine. As far as possible we use some induction therapy. Primary ESRD etiologies were: unknown (74.9%), glomerulonephritis (9.7%) and diabetic nephropathy (4.2%). Recipient's mean age was 29.9 +/- 11.6 years (12-70) and 35 +/- 9.8 years (18-62) in donors. Analysis group for graft and patient survival included 292 transplants (censured for death with functional graft) with a follow-up of 103 months (CI 95%: 99-108). Survival at 1, 5 and 10 years were: 95, 85 and 60% for graft as well as 100, 94 and 90% for patient. In year 2000 we started to perform renal biopsies at transplant (time zero biopsies), those results have been published and at present are a worldwide reference. In September, 2005 laparoscopic donor nephrectomy is initiated, 180 procedures have been done with excellent results. In year 2006, training in renal transplant acquires the endorsement as a Medicine Posgrade recognized by the UNAM School of Medicine. We have participated in 9 national clinical trials and 6 international multicentric ones. Our renal transplant program offers a good choice for patients with low resources with similar results reported in the literature using current immunosuppressive schemes and surgical procedures. Institutional authorities and humanitarian associations support in addition to participation on investigation studies have been of vital importance.

  19. EPIDEMIOLOGY OF ACETABULUM FRACTURES TREATED AT THE INSTITUTO NACIONAL DE TRAUMATOLOGIA E ORTOPEDIA (INTO)

    PubMed Central

    Dias, Marcus Vinícius Fernandes; Goldsztajn, Flavio; Guimarães, João Matheus; Grizendi, José Afraneo; Correia, Marcos; Rocha, Tito Henrique

    2015-01-01

    Objectives: The purpose of this study was to review the epidemiological aspects of displacement fractures of the acetabulum that had been treated surgically at the National Institute of Traumatology and Orthopedics (INTO). Methods: We retrospectively analyzed 126 acetabulum fractures that had been treated surgically at INTO between March 2006 and November 2008. The following factors were taken into account: age, sex, trauma mechanism, injury classification, time elapsed between trauma and surgery, affected side and associated bone injuries. Results: 76.8% were male; the mean age was 39.6 years. The trauma mechanism was traffic accidents in 59%; the time that elapsed between injury and surgery was on average 16.4 days; 55% of the cases were on the right side; 30% of the patients presented associated fractures. Conclusion: Most of the patients were male, in an economically active age group, and were victims of traffic accidents. Edge and/or posterior column fractures were the most frequent types. Associated injuries were common and most of the fractures operated in our service came to us late. PMID:27022597

  20. [The training of specialists at the Instituto Mexicano de Seguro Social. Towards a new evaluation system].

    PubMed

    Viniegra Velázquez, Leonardo

    2005-01-01

    We present the new system for the evaluation of the medical specialization courses at the IMSS which will substitute in 2005 the one used at present. This system derives from a participative conception of education and has as an axis the development of aptitudes. For participative education, knowledge is the result of the student's elaboration, and not the result of the consumption of information. An aptitude is the conjunction of knowledge, abilities and attitudes in a constant development which gives the bearer experience a growing penetration to understand the problematic situations that challenge him, a greater reach of the decisions and actions performed and progressive pertinence to positively influence the working environment. The new evaluation system is centered in the development of two types of aptitude: the clinical aptitude and the aptitude for the appropriate use of information sources. It has an explanatory and instructions section, as well as four types of forms: (a) evaluation of the aptitudes development through time. (b) Performance of activities (in the service and academic) related with the aptitudes seeking to develop. (c) Evaluation of the academic and working environment, and (d) self evaluation. With the new system of evaluation of the formation of medical specialists we pretend to contribute to the overcoming of the educative labors at the Institute, by orienting the professors' and students' reflection towards the main aspects of learning, as well as promote the criticism and self-criticism.

  1. Outcomes with the Boston Type 1 Keratoprosthesis at Instituto de Microcirugía Ocular IMO

    PubMed Central

    Güell, Jose L.; Arcos, Edilio; Gris, Oscar; Aristizabal, Diego; Pacheco, Miguel; Sanchez, Claudia L.; Manero, Felicidad

    2011-01-01

    Purpose To report the outcomes on the Boston Type 1 Keratoprosthesis at our institution. Design Retrospective analysis case series. Participants We analyzed 54 eyes of 53 patients who previously underwent Boston Type 1 Keratoprosthesis surgery at our institution from July 2006 to March 2011. Methods Preoperative and postoperative parameters were collected and analyzed. Main outcome measures Visual acuity and keratoprosthesis stability. Results Common preoperative diagnoses were penetrating keratoplasty failure in 49 eyes (90.7%), chronic keratitis in 2 eyes (3.7%), ocular cicatricial pemphigoid in 1 eye (1.85%), Stevens Johnson syndrome in 1 eye (1.85%) and corneal vascularization in 1 eye (1.85%). Additionally, 40 eyes (74%) had preoperative glaucoma, and an Ahmed valve was implanted in 55% of them. Preoperative BCVA ranged from 20/200 to light perception. At an average follow-up of 20.15 months ± 12.7 (range, 1–56), postoperative vision improved to ⩾20/200 in 18 eyes (33.3%) and ⩾20/50 in 4 eyes (7.4%). The graft retention was 96%. Conclusions The Boston Type 1 keratoprosthesis is a valid option for high-risk patients. The design improvements in the Boston keratoprosthesis, as well as the daily implementation of the therapeutic methods, have notably diminished occurrence of the most serious complications, such as corneal necrosis and endophthalmitis. As such, glaucoma and its subsequent complications now stand as the most prevalent prognostic factor in the long term. PMID:23960937

  2. [Extrinsic allergic alveolitis. Clinical experience at the Instituto National de Enfermedades Respiratorias (INER)].

    PubMed

    Chapela-Mendoza, R; Selman-Lama, M

    1999-01-01

    Extrinsic allergic alveolitis is an interstitial lung disease caused by exposure to a variety of inhaled antigens. In Mexico, the most frequent form is due to the inhalation of avian antigens, markedly pigeon proteins. Depending on type and time exposure, the disease presents different clinical forms usually characterized by progressive dyspnea, ground glass or reticulonodular images on chest x rays, a restrictive functional pattern, rest hypoxemia worsening with exercise, and increase of T lymphocytes in bronchoalveolar lavage with an inversion in the helper/suppressor ratio. In this paper, we discuss a 15-year experience with this pathological problem in Mexico, emphasizing the differences with this disorder in Caucasian populations. Generally, our patients display a chronic form of the disease, which evolves to fibrosis in about one-half of the patients. In this sense, the diagnostic, prognostic, and therapeutic focusing exhibit different elements, and thus the development of clinical and basic research is strongly required.

  3. 78 FR 74008 - Amendment of Class E Airspace; Del Rio, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-10

    ... Del Rio, TX, area, creating additional controlled airspace at Laughlin AFB (78 FR 52716) Docket No... Regulatory Policies and Procedures (44 FR 11034; February 26, 1979); and (3) does not warrant preparation of... FR 9565, 3 CFR, 1959-1963 Comp., p. 389. ] Sec. 71.1 0 2. The incorporation by reference in 14 CFR...

  4. Community Arts Programs: Cohesion and Difference Case Studies. Henry Street Settlement and El Museo del Barrio

    ERIC Educational Resources Information Center

    Kiebert-Gruen, Cathleen

    2009-01-01

    A comparative case study of two cultural institutions, Henry Street Settlement and El Museo del Barrio, founded almost eighty years apart, were involved in social justice causes and community arts. Although both of these institutions participated in the political activism of their time, they also demonstrated an important adaptability. They were…

  5. 33 CFR 162.200 - Marina del Rey, Calif.; restricted area.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... dealing with this section in 33 CFR Part 207. ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Marina del Rey, Calif... SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY INLAND WATERWAYS NAVIGATION REGULATIONS § 162.200...

  6. 33 CFR 162.200 - Marina del Rey, Calif.; restricted area.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... dealing with this section in 33 CFR Part 207. ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Marina del Rey, Calif... SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY INLAND WATERWAYS NAVIGATION REGULATIONS § 162.200...

  7. Dropouts, Stopouts, Optouts at Del Mar College: Spring 1991. Report of a Joint Research Project.

    ERIC Educational Resources Information Center

    Luckie, Jo Ann I.; Bonham, L. Adrianne

    A research project investigated 2,313 persons who attended Del Mar College (Texas) during fall 1990 but did not enroll for spring 1991. Four sets of data were collected: (1) limited demographic information on the total student body; (2) demographic information drawn from school records to describe all nonreturnees; (3) demographic information…

  8. ATMOSPHERIC VOLATILE ORGANIC COMPOUND MEASUREMENTS DURING THE 1996 PASO DEL NORTE OZONE STUDY

    EPA Science Inventory

    Ambient air VOC samples were collected at surface air quality monitoring sites, near sources of interest, and aloft on the US (El Paso) and Mexican (Ciudad Juarez) side of the border during a six-week period of the 1996 Paso del Norte Ozone Study. Samples were collected at five...

  9. Acantholachesilla gen. n. (Psocodea:'Psocoptera': Lachesillidae: Eolachesillinae: Graphocaeciliini) from Valle del Cauca, Colombia.

    PubMed

    Aldrete, Alfonso N García; Manchola, Oscar Fernando Saenz; Obando, Ranulfo González

    2014-06-25

    Acantholachesilla saltoensis gen. et sp. n. is described from Valle del Cauca, Colombia, in the Lachesillidae, tribe Graphocaeciliini (Eolachesillinae). The genus is related to Dagualachesilla and Dagualachesilloides that occur in the same area, differing from them in the male clunial projection, phallosome, and female subgenital plate and gonapophyses.

  10. 33 CFR 334.110 - Delaware Bay off Cape Henlopen, Del.; naval restricted area.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Delaware Bay off Cape Henlopen, Del.; naval restricted area. 334.110 Section 334.110 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS §...

  11. 33 CFR 162.35 - Channel of Christina River, Del.; navigation.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Channel of Christina River, Del.; navigation. 162.35 Section 162.35 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY INLAND WATERWAYS NAVIGATION REGULATIONS § 162.35 Channel...

  12. 33 CFR 162.35 - Channel of Christina River, Del.; navigation.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Channel of Christina River, Del.; navigation. 162.35 Section 162.35 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY INLAND WATERWAYS NAVIGATION REGULATIONS § 162.35 Channel...

  13. 33 CFR 162.35 - Channel of Christina River, Del.; navigation.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Channel of Christina River, Del.; navigation. 162.35 Section 162.35 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY INLAND WATERWAYS NAVIGATION REGULATIONS § 162.35 Channel...

  14. 33 CFR 162.35 - Channel of Christina River, Del.; navigation.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Channel of Christina River, Del.; navigation. 162.35 Section 162.35 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY INLAND WATERWAYS NAVIGATION REGULATIONS § 162.35 Channel...

  15. 33 CFR 162.35 - Channel of Christina River, Del.; navigation.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Channel of Christina River, Del.; navigation. 162.35 Section 162.35 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PORTS AND WATERWAYS SAFETY INLAND WATERWAYS NAVIGATION REGULATIONS § 162.35 Channel...

  16. New record of Paralomis spinosissima Birstein & Vinogradov (Decapoda: Anomura: Lithodidae) from Mar del Plata, Argentina.

    PubMed

    Olguín, Nicole; Ocampo, Emiliano H; Farias, Nahuel

    2015-05-14

    The lithodid crab Paralomis spinosissima is previously known only in Sub-Antarctic waters from South Georgia Island to the Drake Passage. Here we recorded a juvenile male obtained off shores of Mar del Plata (~37°S), Argentina. This new occurrence extends the distribution range of the species over 1300 km northwards in the Atlantic Ocean.

  17. Ouabain Mimics Low Temperature Rescue of F508del-CFTR in Cystic Fibrosis Epithelial Cells

    PubMed Central

    Zhang, Donglei; Ciciriello, Fabiana; Anjos, Suzana M.; Carissimo, Annamaria; Liao, Jie; Carlile, Graeme W.; Balghi, Haouaria; Robert, Renaud; Luini, Alberto; Hanrahan, John W.; Thomas, David Y.

    2012-01-01

    Most cases of cystic fibrosis (CF) are caused by the deletion of a single phenylalanine residue at position 508 of the cystic fibrosis transmembrane conductance regulator (CFTR). The mutant F508del-CFTR is retained in the endoplasmic reticulum and degraded, but can be induced by low temperature incubation (29°C) to traffic to the plasma membrane where it functions as a chloride channel. Here we show that, cardiac glycosides, at nanomolar concentrations, can partially correct the trafficking of F508del-CFTR in human CF bronchial epithelial cells (CFBE41o-) and in an F508del-CFTR mouse model. Comparison of the transcriptional profiles obtained with polarized CFBE41o-cells after treatment with ouabain and by low temperature has revealed a striking similarity between the two corrector treatments that is not shared with other correctors. In summary, our study shows a novel function of ouabain and its analogs in the regulation of F508del-CFTR trafficking and suggests that compounds that mimic this low temperature correction of trafficking will provide new avenues for the development of therapeutics for CF. PMID:23060796

  18. Self-consistent Gödel cosmology with spin-density in Riemann-Cartan spacetime

    NASA Astrophysics Data System (ADS)

    Smalley, Larry L.

    1986-01-01

    We show that the Gödel metric for a rotating cosmology is compatible with the self-consistent formulation of the Einstein-Cartan metric-torsion theory for a spinning fluid. Fruitful discussions with J.R. Ray and F.W. Hehl are greatfully acknowledged. I wish to also thank J. Bradas who brought a reference to my attention.

  19. Calcio y la prevención del cáncer

    Cancer.gov

    Hoja informativa que resume los resultados de estudios sobre el calcio y la prevención del cáncer. Incluye información sobre las recomendaciones dietéticas para calcio y la cantidad de calcio en los alimentos y en complementos de calcio.

  20. Shed Some Light on the Subject: Teaching Ramon del Valle-Inclan's "Luces de bohemia"

    ERIC Educational Resources Information Center

    Parker, Jason Thomas

    2011-01-01

    This essay seeks to provide parallel and interchangeable approaches to teaching Ramon del Valle-Inclan's challenging play "Luces de bohemia". A greater understanding of the cultural and mental frameworks of the early twentieth-century Spanish spectator will permit students to penetrate the dense intertextuality that characterizes Valle's…

  1. Informe del NCI y los CDC sobre el tabaco sin humo

    Cancer.gov

    El primer informe sobre el consumo mundial del tabaco sin humo y sus consecuencias en la salud pública reveló que más de 300 millones de personas en al menos 70 países usan estos productos dañinos.

  2. Exploración del Nuevo Laboratorio Científico de Marte

    NASA Video Gallery

    Únase a Fernando Abilleira, un analista de trayectoria de la NASA para la Oficina de Exploración de Marte, y conozca las nuevas tecnologías que el nuevo robot Curiosity del Laboratorio Científico d...

  3. Control del dolor: Apoyo para las personas con cáncer

    Cancer.gov

    Contiene información sobre las medicinas contra el dolor para pacientes con cáncer, los planes para controlarlo, cómo hablar con su equipo de atención médica sobre el dolor que usted siente y qué hacer para controlar los efectos físicos y emocionales del

  4. A tectonically controlled basin-fill within the Valle del Cauca, West-Central Colombia

    SciTech Connect

    Rine, J.M.; Keith, J.F. Jr.; Alfonso, C.A.; Ballesteros, I.; Laverde, F.; Sacks, P.E.; Secor, D.T. Jr. ); Perez, V.E.; Bernal, I.; Cordoba, F.; Numpaque, L.E. )

    1993-02-01

    Tertiary strata of the Valle del Cauca reflect a forearc/foreland basin tectonic history spanning a period from pre-uplift of the Cordillera Central to initiation of uplift of the Cordillera Occidental. Stratigraphy of the Valle del Cauca begins with Jurassic-Cretaceous rocks of exotic and/or volcanic provenance and of oceanic origin. Unconformably overlying these are Eocene to Oligocene basal quartz-rich sandstones, shallow marine algal limestones, and fine-grained fluvial/deltaic mudstones and sandstones with coalbeds. These Eocene to Oligocene deposits represent a period of low tectonic activity. During late Oligocene to early Miocene, increased tectonic activity produced conglomeratic sediments which were transported from east to west, apparently derived from uplift of the Cordillera Central, and deposited within a fluvial to deltaic setting. East-west shortening of the Valle del Cauca basin folded the Eocene to early Miocene units, and additional uplift of the Cordillera Central during the later Miocene resulted in syn-tectonic deposition of alluvial fans. After additional fold and thrust deformation of the total Eocene-Miocene basin-fill, tectonic activity abated and Pliocene-Quaternary alluvial and lacustrine strata were deposited. Within the framework of this depositional and tectonic history of the Valle del Cauca, hydrocarbon exploration strategies can be formulated and evaluated.

  5. Plan Multinacional de Educacion del Adulto (Multinational Plan for Adult Education).

    ERIC Educational Resources Information Center

    Eduplan Informa, 1971

    1971-01-01

    This document contains part of the final report from the first meeting of the Inter-American Council on Education, Science, and Culture, held in Vina del Mar, Chile, in 1970. The report presents general policy and guidelines which should be followed in the establishment of adult elementary education programs. The general discussion covers literacy…

  6. Exploración del Sistema Solar -- Una mirada hacia el futuro

    NASA Video Gallery

    ¿Piensas que ya sabemos todo acerca de nuestro sistema solar? La realidad es que apenas hemos comenzado con lo que hay para conocer. Únete a la NASA, en el envío de misiones a los confines del sist...

  7. A Failed Utopia in Marcela Del Río's "Proceso a Faubritten"

    ERIC Educational Resources Information Center

    Manickam, Samuel

    2014-01-01

    In Marcela del Río's science fiction novel "Proceso a Faubritten," utopia comes in the form of eternal life for all of humanity, thanks to Dr. Alexander Faubritten's "Bomba L." This polyphonic work includes diaries by Faubritten and his Mexican lover, María Corona. In my analysis of these two diaries, I will show how…

  8. Gastrointestinal helminths of Commerson's dolphins Cephalorhynchus commersonii from central Patagonia and Tierra del Fuego.

    PubMed

    Berón-Vera, B; Pedraza, S N; Raga, J A; Gil de Pertierra, A; Crespo, E A; Alonso, M K; Goodall RNP

    2001-12-01

    The stomachs and intestines of 9 Commerson's dolphins incidentally caught in trawl nets in central Patagonia and 23 stranded on beaches in Tierra del Fuego were surveyed for helminth parasites. A total of 267 individuals belonging to 4 species of parasites (1 nematode, 3 digeneans) were found in the dolphins from the first area: Anisakis sp. (larvae type 1 = A. simplex), Braunina cordiformis, Hadwenius sp. and Pholeter gastrophilus. In the Tierra del Fuego dolphins, 142 specimens belonging to 3 species (2 nematodes, 1 digenean, 1 cestode) were found: A. simplex, Hadwenius sp. and Strobilocephalus triangularis. Only 2 of the helminth species were shared in the 2 study areas, A. simplex and Hadwenius sp., and both were more common in central Patagonia. Among the species, A. simplex was most prevalent and abundant in both study areas. In Tierra del Fuego, adults of A. simplex appeared in only 1 host. Hadwenius sp., P. gastrophilus and S. triangularis are new host records for Commerson's dolphin. Species diversity and species richness were low in both study areas. Helminth communities were more diverse in central Patagonia (t = 1.97, df = 258, p < 0.05) and species richness was higher in central Patagonia (S = 4). No differences in diversity were observed between females and males of central Patagonia (t = 1.97, df = 139, p < 0.05) and between females of central Patagonia and Tierra del Fuego. The results may suggest some differences in habitat use, diet and sex between Commerson's dolphin populations in the 2 study areas.

  9. Urban Impact of Dissolved Metals in the Paso del Norte Segment of the Rio Grande

    ERIC Educational Resources Information Center

    Freiwan, Sumayeh Ahmad

    2013-01-01

    The Paso del Norte segment of the Rio Grande experiences two seasons per year; the (wet) irrigation season and the (dry) non-irrigation season. The goal of this study was to improve the understanding of occurrence and contribution of dissolved metals in this region during the non-irrigation season. The objectives of this study were to (1) evaluate…

  10. Tratamiento del cáncer sin daño al corazón

    Cancer.gov

    Investigadores de los campos de oncología y de cardiología están trabajando para encontrar formas de impedir, manejar y posiblemente aun revertir los efectos secundarios cardiovasculares de ciertas terapias del cáncer.

  11. Dolores Del Rio, the First "Latin Invasion", and Hollywood's Transition to Sound

    ERIC Educational Resources Information Center

    Beltran, Mary

    2005-01-01

    The career and promotion of Mexican actress Dolores Del Rio as a case study of how Hollywood's shift to sound film affected Latino and Latina actors is examined. It reveals the way in which the starring opportunities for Latinos dwindled when accent and language increasingly marked them as nonwhite in the 1930s in the talkie films.

  12. Synonymous codon usage affects the expression of wild type and F508del CFTR.

    PubMed

    Shah, Kalpit; Cheng, Yi; Hahn, Brian; Bridges, Robert; Bradbury, Neil A; Mueller, David M

    2015-03-27

    The cystic fibrosis transmembrane conductance regulator (CFTR) is an anion channel composed of 1480 amino acids. The major mutation responsible for cystic fibrosis results in loss of amino acid residue, F508 (F508del). Loss of F508 in CFTR alters the folding pathway resulting in endoplasmic-reticulum-associated degradation. This study investigates the role of synonymous codon in the expression of CFTR and CFTR F508del in human HEK293 cells. DNA encoding the open reading frame (ORF) for CFTR containing synonymous codon replacements was expressed using a heterologous vector integrated into the genome. The results indicate that the codon usage greatly affects the expression of CFTR. While the promoter strength driving expression of the ORFs was largely unchanged and the mRNA half-lives were unchanged, the steady-state levels of the mRNA varied by as much as 30-fold. Experiments support that this apparent inconsistency is attributed to nonsense mediated decay independent of exon junction complex. The ratio of CFTR/mRNA indicates that mRNA containing native codons was more efficient in expressing mature CFTR as compared to mRNA containing synonymous high-expression codons. However, when F508del CFTR was expressed after codon optimization, a greater percentage of the protein escaped endoplasmic-reticulum-associated degradation resulting in considerable levels of mature F508del CFTR on the plasma membrane, which showed channel activity. These results indicate that codon usage has an effect on mRNA levels and protein expression, for CFTR, and likely on chaperone-assisted folding pathway, for F508del CFTR.

  13. Synonymous Codon Usage Affects the Expression of Wild Type and F508del CFTR

    PubMed Central

    Shah, Kalpit; Cheng, Yi; Hahn, Brian; Bridges, Robert; Bradbury, Neil; Mueller, David M.

    2015-01-01

    The cystic fibrosis transmembrane conductance regulator (CFTR) is an anion channel composed of 1480 amino acids. The major mutation responsible for cystic fibrosis results in loss of amino acid residue, F508, (F508del). Loss of F508 in CFTR alters the folding pathway resulting in endoplasmic reticulum associated degradation (ERAD). This study investigates the role of synonymous codon in the expression of CFTR and CFTR F508del in human HEK293 cells. DNA encoding the open reading frame (ORF) for CFTR containing synonymous codon replacements, were expressed using a heterologous vector integrated into the genome. The results indicate that the codon usage greatly affects the expression of CFTR. While the promoter strength driving expression of the ORFs was largely unchanged and the mRNA half-lives were unchanged, the steady state levels of the mRNA varied by as much as 30 fold. Experiments support that this apparent inconsistency is attributed to exon junction complex independent nonsense mediated decay. The ratio of CFTR/mRNA indicates that mRNA containing native codons was more efficient in expressing mature CFTR as compared to mRNA containing synonymous high expression codons. However, when F508del CFTR was expressed after codon optimization, a greater percentage of the protein escaped ERAD resulting in considerable levels of mature F508del CFTR on the plasma membrane, which showed channel activity. These results indicate that for CFTR, codon usage has an effect on mRNA levels, protein expression and likely, for F508del CFTR, chaperone assisted folding pathway. PMID:25676312

  14. Determinacion de periodos fundamentales del suelo mediante vibraciones ambientales en el municipio de Humacao, Puerto Rico

    NASA Astrophysics Data System (ADS)

    Cintron Aponte, Rommel

    La tecnica de Nakamura ha sido utilizada a nivel mundial para determinar periodos fundamentales del suelo. La tecnica consiste en calcular y graficar cocientes espectrales H/V de vibraciones ambientales registradas sobre el suelo. Mediciones de vibraciones ambientales fueron tomadas en 151 lugares dentro del municipio de Humacao, localizado al este de Puerto Rico. Los datos se procesaron utilizando espectros de Fourier y espectros de potencia. La tecnica fue validada al compararla con los resultados de cocientes espectrales H/V de registros de sismos debiles y tambien con una modelacion numerica realizada con datos de un ensayo "downhole". Las graficas de los cocientes espectrales H/V fueron divididas en casos y grupos, los cuales dependen de la facilidad para identificar el periodo fundamental pico y amplitudes en frecuencias menores de 1 Hz, respectivamente. Los resultados obtenidos con ambos espectros fueron comparados y se concluye que los mismos se complementan para proveer resultados mas confiables. Se crearon mapas de periodos fundamentales, factores de amplitud, isoperiodos y clasificacion sismica de sitio. Los mapas de isoperiodos fueron realizados en las zonas mas pobladas sobre depositos de suelo. El mapa de periodos fundamentales del suelo mostro buena correlacion con la geologia local. El mapa de clasificacion sismica derivado de periodos de sitio fue comparado con el mapa de clasificacion sismica derivado de barrenos geotecnicos. El mapa de clasificacion obtenido de periodos puede sobreestimar un poco algunas clasificaciones del suelo. Sin embargo, este mapa puede proveer un estimado aproximado de la velocidad de onda de corte promedio del suelo hasta una profundidad de 100 pies (30 metros).

  15. Toric K3-fibred Calabi-Yau manifolds with del Pezzo divisors for string compactifications

    NASA Astrophysics Data System (ADS)

    Cicoli, Michele; Kreuzer, Maximilian; Mayrhofer, Christoph

    2012-02-01

    We analyse several explicit toric examples of compact K3-fibred Calabi-Yau three-folds. These manifolds can be used for the study of string dualities and are crucial ingredients for the construction of LARGE Volume type IIB vacua with promising applications to cosmology and particle phenomenology. In order to build a phenomenologically viable model, on top of the two moduli corresponding to the base and the K3 fibre, we demand also the existence of two additional rigid divisors: the first supporting the non-perturbative effects needed to achieve moduli stabilisation, and the second allowing the presence of chiral matter on wrapped D-branes. We clarify the topology of these rigid divisors by discussing the interplay between a diagonal structure of the Calabi-Yau volume and D-terms. Del Pezzo divisors appearing in the volume form in a completely diagonal way are natural candidates for supporting non-perturbative effects and for quiver constructions, while `non-diagonal' del Pezzo and rigid but not del Pezzo divisors are particularly interesting for model building in the geometric regime. Searching through the existing list of four dimensional reflexive lattice polytopes, we find 158 examples admitting a Calabi-Yau hypersurface with a K3 fibration and four Kähler moduli where at least one of the toric divisors is a `diagonal' del Pezzo. We work out explicitly the topological details of a few examples showing how, in the case of simplicial polytopes, all the del Pezzo divisors are `diagonal', while `non-diagonal' ones appear only in the case of non-simplicial polytopes. A companion paper will use these results in the study of moduli stabilisation for globally consistent explicit Calabi-Yau compactifications with the local presence of chirality.

  16. Percepcion de los profesores universitarios acerca del concepto cultura cientifica y de sus implicaciones en el nuevo bachillerato del Recinto de Rio Piedras de la Universidad de Puerto Rico

    NASA Astrophysics Data System (ADS)

    Ramos Pastrana, Nilsa

    El Senado Academico del Recinto de Rio Piedras de la Universidad de Puerto Rico aprobo en el ano academico 2005-2006 la Certificacion 46, que contiene los lineamientos de un nuevo bachillerato. Este nuevo bachillerato introdujo cambios significativos en el curriculo tradicional. Entre ellos se encuentra la reduccion del componente de educacion general y el de Ciencias Biologicas en particular. La reduccion de creditos en el componente de Ciencias Biologicas ha obligado a reevaluar el concepto de cultura cientifica que desarrollan esos cursos. El proposito del estudio consistio en auscultar las percepciones de los profesores de las Facultades de Administracion de Empresas, Humanidades, Ciencias Sociales, Ciencias Naturales, Educacion y Estudios Generales del Recinto de Rio Piedras de la Universidad de Puerto Rico en torno al concepto de cultura cientifica, los contenidos disciplinares del curso de Ciencias Biologicas y la reduccion de creditos en el nuevo bachillerato. Las preguntas que guiaron la investigacion fueron: ¿cuales son las percepciones que tienen los profesores de las Facultades de Administracion de Empresas, Ciencias Sociales, Estudios Generales, Ciencias Naturales, Humanidades y Educacion, en torno al concepto de cultura cientifica y los contenidos disciplinares del curso de Ciencias Biologicas? ¿cuales son las percepciones que tienen los profesores de Ciencias Biologicas en torno al concepto cultura cientifica y los contenidos disciplinares del curso de Ciencias Biologicas? ¿existen diferencias significativas por facultad, genero, experiencia, rango y nombramiento en las percepciones que tienen los profesores del Recinto de Rio Piedras de la Universidad de Puerto Rico sobre los elementos que caracterizan la cultura cientifica y los contenidos biologicos que deben tener los egresados del Recinto? ¿que implicaciones curriculares tienen estos testimonios en el desarrollo del concepto de cultura cientifica en el nuevo bachillerato? Para realizar la

  17. Trimethylangelicin promotes the functional rescue of mutant F508del CFTR protein in cystic fibrosis airway cells.

    PubMed

    Favia, Maria; Mancini, Maria T; Bezzerri, Valentino; Guerra, Lorenzo; Laselva, Onofrio; Abbattiscianni, Anna C; Debellis, Lucantonio; Reshkin, Stephan J; Gambari, Roberto; Cabrini, Giulio; Casavola, Valeria

    2014-07-01

    Cystic fibrosis transmembrane conductance regulator (CFTR) carrying the F508del mutation is retained in endoplasmic reticulum and fails to traffic to the cell surface where it functions as a protein kinase A (PKA)-activated chloride channel. Pharmacological correctors that rescue the trafficking of F508del CFTR may overcome this defect; however, the rescued F508del CFTR still displays reduced chloride permeability. Therefore, a combined administration of correctors and potentiators of the gating defect is ideal. We recently found that 4,6,4'-trimethylangelicin (TMA), besides inhibiting the expression of the IL-8 gene in airway cells in which the inflammatory response was challenged with Pseudomonas aeruginosa, also potentiates the cAMP/PKA-dependent activation of wild-type CFTR or F508del CFTR that has been restored to the plasma membrane. Here, we demonstrate that long preincubation with nanomolar concentrations of TMA is able to effectively rescue both F508del CFTR-dependent chloride secretion and F508del CFTR cell surface expression in both primary or secondary airway cell monolayers homozygous for F508del mutation. The correction effect of TMA seems to be selective for CFTR and persisted for 24 h after washout. Altogether, the results suggest that TMA, besides its anti-inflammatory and potentiator activities, also displays corrector properties.

  18. Development of InDel markers for Brassica rapa based on whole-genome re-sequencing.

    PubMed

    Liu, Bo; Wang, Yan; Zhai, Wen; Deng, Jie; Wang, Hui; Cui, Yang; Cheng, Feng; Wang, Xiaowu; Wu, Jian

    2013-01-01

    Genome-wide detection of short insertion/deletion length polymorphisms (InDels, <5 bp) in Brassica rapa (named the A genome) was performed by comparing whole-genome re-sequencing data from two B. rapa accessions, L144 and Z16, to the reference genome sequence of Chiifu-401-42. In total, we identified 108,558 InDel polymorphisms between Chiifu-401-42 and L144, 26,795 InDels between Z16 and Chiifu-401-42, and 26,693 InDels between L144 and Z16. From these, 639 InDel polymorphisms of 3-5 bp in length between L144 and Z16 were selected for experimental validation; 491 (77%) yielded single PCR fragments and showed polymorphisms, 7 (1%) did not amplify a product, and 141 (22%) showed no polymorphism. For further validation of these intra-specific InDel polymorphisms, 503 candidates, randomly selected from the 639 InDels, were screened across seven accessions representing different B. rapa cultivar groups. Of these assayed markers, 387 (77%) were polymorphic, 111 (22%) were not polymorphic and 5 (1%) did not amplify a PCR product. Furthermore, we randomly selected 518 InDel markers to validate their polymorphism in B. napus (the AC genome) and B. juncea (the AB genome), of which more than 90% amplified a PCR product; 132 (25%) showed polymorphism between the two B. napus accessions and 41 (8%) between the two B. juncea accessions. This set of novel PCR-based InDel markers will be a valuable resource for genetic studies and breeding programs in B. rapa.

  19. CHEK2*1100delC homozygosity in the Netherlands--prevalence and risk of breast and lung cancer.

    PubMed

    Huijts, Petra E A; Hollestelle, Antoinette; Balliu, Brunilda; Houwing-Duistermaat, Jeanine J; Meijers, Caro M; Blom, Jannet C; Ozturk, Bahar; Krol-Warmerdam, Elly M M; Wijnen, Juul; Berns, Els M J J; Martens, John W M; Seynaeve, Caroline; Kiemeney, Lambertus A; van der Heijden, Henricus F; Tollenaar, Rob A E M; Devilee, Peter; van Asperen, Christi J

    2014-01-01

    The 1100delC mutation in the CHEK2 gene has a carrier frequency of up to 1.5% in individuals from North-West Europe. Women heterozygous for 1100delC have an increased breast cancer risk (odds ratio 2.7). To explore the prevalence and clinical consequences of 1100delC homozygosity in the Netherlands, we genotyped a sporadic breast cancer hospital-based cohort, a group of non-BRCA1/2 breast cancer families, and breast tumors from a tumor tissue bank. Three 1100delC homozygous patients were found in the cohort of 1434 sporadic breast cancer patients, suggesting an increased breast cancer risk for 1100delC homozygotes (odds ratio 3.4, 95% confidence interval 0.4-32.6, P=0.3). Another 1100delC homozygote was found in 592 individuals from 108 non-BRCA1/2 breast cancer families, and two more were found after testing 1706 breast tumors and confirming homozygosity on their wild-type DNA. Follow-up data was available for five homozygous patients, and remarkably, three of them had developed contralateral breast cancer. A possible relationship between 1100delC and lung cancer risk was investigated in 457 unrelated lung cancer patients but could not be confirmed. Due to the small number of 1100delC homozygotes identified, the breast cancer risk estimate associated with this genotype had limited accuracy but is probably higher than the risk in heterozygous females. Screening for CHEK2 1100delC could be beneficial in countries with a relatively high allele frequency.

  20. Development of InDel markers for Brassica rapa based on whole-genome re-sequencing.

    PubMed

    Liu, Bo; Wang, Yan; Zhai, Wen; Deng, Jie; Wang, Hui; Cui, Yang; Cheng, Feng; Wang, Xiaowu; Wu, Jian

    2013-01-01

    Genome-wide detection of short insertion/deletion length polymorphisms (InDels, <5 bp) in Brassica rapa (named the A genome) was performed by comparing whole-genome re-sequencing data from two B. rapa accessions, L144 and Z16, to the reference genome sequence of Chiifu-401-42. In total, we identified 108,558 InDel polymorphisms between Chiifu-401-42 and L144, 26,795 InDels between Z16 and Chiifu-401-42, and 26,693 InDels between L144 and Z16. From these, 639 InDel polymorphisms of 3-5 bp in length between L144 and Z16 were selected for experimental validation; 491 (77%) yielded single PCR fragments and showed polymorphisms, 7 (1%) did not amplify a product, and 141 (22%) showed no polymorphism. For further validation of these intra-specific InDel polymorphisms, 503 candidates, randomly selected from the 639 InDels, were screened across seven accessions representing different B. rapa cultivar groups. Of these assayed markers, 387 (77%) were polymorphic, 111 (22%) were not polymorphic and 5 (1%) did not amplify a PCR product. Furthermore, we randomly selected 518 InDel markers to validate their polymorphism in B. napus (the AC genome) and B. juncea (the AB genome), of which more than 90% amplified a PCR product; 132 (25%) showed polymorphism between the two B. napus accessions and 41 (8%) between the two B. juncea accessions. This set of novel PCR-based InDel markers will be a valuable resource for genetic studies and breeding programs in B. rapa. PMID:22972202

  1. Rescue of F508del-CFTR by RXR motif inactivation triggers proteome modulation associated with the unfolded protein response.

    PubMed

    Gomes-Alves, Patrícia; Couto, Francisco; Pesquita, Cátia; Coelho, Ana V; Penque, Deborah

    2010-04-01

    F508del-CFTR, the most common mutation of the cystic fibrosis transmembrane conductance regulator (CFTR) protein, disrupts intracellular trafficking leading to cystic fibrosis (CF). The trafficking defect of F508del-CFTR can be rescued by simultaneous inactivation of its four RXR motifs (4RK). Proteins involved in the F508del-CFTR trafficking defect and/or rescue are therefore potential CF therapeutic targets. We sought to identify these proteins by investigating differential proteome modulation in BHK cells over-expressing wt-CFTR, F508del-CFTR or the revertant F508del/4RK-CFTR. By 2-dimensional electrophoresis-based proteomics and western blot approaches we demonstrated that over-expression of F508del/4RK-CFTR modulates the expression of a large number of proteins, many of which are reported interactors of CFTR and/or 14-3-3 with potential roles in CFTR trafficking. GRP78/BiP, a marker of ER stress and unfolded protein response (UPR), is up-regulated in cells over-expressing either F508del-CFTR or F598del/4RK-CFTR. However, over-expression of F508del/4RK-CFTR induces the up-regulation of many other UPR-associated proteins (e.g. GRP94, PDI, GRP75/mortalin) and, interestingly, the down-regulation of proteasome components associated with CFTR degradation, such as the proteasome activator PA28 (PSME2) and COP9 signalosome (COPS5/CSN5). Moreover, the F508del-CFTR-induced proteostasis imbalance, which involves some heat shock chaperones (e.g. HSP72/Hpa2), ER-EF-hand Ca(2+)-binding proteins (calumenin) and the proteasome activator PA28 (PSME2), tends to be 'restored', i.e., in BHK cells over-expressing F508del/4RK-CFTR those proteins tend to have expression levels similar to the wild-type ones. These findings indicate that a particular cellular environment orchestrated by the UPR contributes to and/or is compatible with F508del/4RK-CFTR rescue. PMID:20044041

  2. Estudio del Hidrógeno neutro en dirección al remanente de supernova W28

    NASA Astrophysics Data System (ADS)

    Dubner, G.; Velazquez, P.; Green, A.; Goss, W. M.; Reynoso, E.

    Se presenta un relevamiento del hidrógeno neutro alrededor del remanente de supernova W28 realizado con el radiotelescopio australiano de Parkes. Se analizan rasgos de emisión y absorción. Se muestra la existencia de estructuras anulares asociadas con el remanente. Se compara la distribución del hidrógeno neutro con la ubicación de máseres de OH detectados en la línea de 1720 MHz.

  3. Rescue of F508del-CFTR by RXR motif inactivation triggers proteome modulation associated with the unfolded protein response.

    PubMed

    Gomes-Alves, Patrícia; Couto, Francisco; Pesquita, Cátia; Coelho, Ana V; Penque, Deborah

    2010-04-01

    F508del-CFTR, the most common mutation of the cystic fibrosis transmembrane conductance regulator (CFTR) protein, disrupts intracellular trafficking leading to cystic fibrosis (CF). The trafficking defect of F508del-CFTR can be rescued by simultaneous inactivation of its four RXR motifs (4RK). Proteins involved in the F508del-CFTR trafficking defect and/or rescue are therefore potential CF therapeutic targets. We sought to identify these proteins by investigating differential proteome modulation in BHK cells over-expressing wt-CFTR, F508del-CFTR or the revertant F508del/4RK-CFTR. By 2-dimensional electrophoresis-based proteomics and western blot approaches we demonstrated that over-expression of F508del/4RK-CFTR modulates the expression of a large number of proteins, many of which are reported interactors of CFTR and/or 14-3-3 with potential roles in CFTR trafficking. GRP78/BiP, a marker of ER stress and unfolded protein response (UPR), is up-regulated in cells over-expressing either F508del-CFTR or F598del/4RK-CFTR. However, over-expression of F508del/4RK-CFTR induces the up-regulation of many other UPR-associated proteins (e.g. GRP94, PDI, GRP75/mortalin) and, interestingly, the down-regulation of proteasome components associated with CFTR degradation, such as the proteasome activator PA28 (PSME2) and COP9 signalosome (COPS5/CSN5). Moreover, the F508del-CFTR-induced proteostasis imbalance, which involves some heat shock chaperones (e.g. HSP72/Hpa2), ER-EF-hand Ca(2+)-binding proteins (calumenin) and the proteasome activator PA28 (PSME2), tends to be 'restored', i.e., in BHK cells over-expressing F508del/4RK-CFTR those proteins tend to have expression levels similar to the wild-type ones. These findings indicate that a particular cellular environment orchestrated by the UPR contributes to and/or is compatible with F508del/4RK-CFTR rescue.

  4. Acerca de este sitio web

    Cancer.gov

    Página de guía que permite al lector entender la forma en que está organizado el sitio web del Instituto Nacional del Cáncer (NCI), las categorías de información disponibles y las políticas que rigen este sitio web.

  5. Tumores cerebrales—Versión para pacientes

    Cancer.gov

    Información del Instituto Nacional del Cáncer sobre el tratamiento de los tumores cerebrales, así como referencias a estudios clínicos, estadísticas y otros temas relacionados con estos tipos de cáncer.

  6. Leucemia—Versión para pacientes

    Cancer.gov

    Información del Instituto Nacional del Cáncer sobre el tratamiento de la leucemia, así como referencias a estudios clínicos, investigación, estadísticas y otros temas relacionados con este tipo de cáncer.

  7. Leucemia—Versión para profesionales de salud

    Cancer.gov

    Información del Instituto Nacional del Cáncer para profesionales de salud sobre el tratamiento de la leucemia, así como referencias a estudios clínicos, investigación, estadísticas y otros temas relacionados con este tipo de cáncer.

  8. Centros oncológicos designados por el NCI

    Cancer.gov

    El programa de centros oncológicos designados por el Instituto Nacional del Cáncer (NCI) reconoce a los centros de todo el país que cumplen con rigurosos criterios para participar en proyectos avanzados de primer nivel para la investigación multidisciplinaria del cáncer.

  9. Cáncer de cabeza y cuello—Versión para pacientes

    Cancer.gov

    Información del Instituto Nacional del Cáncer sobre el tratamiento, la prevención, las causas y los exámenes de detección de los cánceres de cabeza y cuello, así como referencias a estudios clínicos, investigaciones, estadísticas y temas relacionados.

  10. Enfermedad trofoblástica de la gestación—Versión para profesionales de salud

    Cancer.gov

    Información del Instituto Nacional del Cáncer para profesionales de salud sobre el tratamiento de la enfermedad trofoblástica de la gestación, así como referencias a estudios clínicos y otros temas relacionados.

  11. Tumores cerebrales—Versión para profesionales de salud

    Cancer.gov

    Información del Instituto Nacional del Cáncer para profesionales de salud sobre el tratamiento de los tumores cerebrales, así como referencias a estudios clínicos, estadísticas y otros temas relacionados con estos tipos de cáncer.

  12. [Research in pediatrics].

    PubMed

    Herrera-Márquez, Julia Rocío; González-Cabello, Héctor Jaime

    2015-01-01

    In the interest of encouraging the promotion of research done by physicians of the Instituto Mexicano del Seguro Social, in this supplement we publish articles written by residents of different specialties related to critical themes on pediatrics. These residents are guided by affiliated physicians from the Hospital de Pediatría del Centro Médico Nacional Siglo XXI.

  13. Physiological profile of fighters influences training organisation in combat sports: response to Del Vecchio, Hirata, and Franchini (2011).

    PubMed

    Paillard, Thierry

    2011-12-01

    The article by Del Vecchio, et al. (2011) provides relevant information to trainers about the effort-pause ratio during mixed martial arts matches. Taking into account the physiological profiles of fighters would increase interest in these findings. PMID:22403925

  14. Ground Gravity, Magnetic and Electromagnetic Surveys on a Crater on Basalt of Bajada del Diablo Astrobleme-Strewn Field

    NASA Astrophysics Data System (ADS)

    Acevedo, R. D.; Prezzi, C.; Orgeira, M. J.; Rocca, M.; Martínez, O.; Ponce, J. F.; Corbella, H.; Rabassa, J.; González-Guillot, M.; Subías, I.

    2014-09-01

    With the aim of further investigate the circular structures from Bajada del Diablo, we carried out geophysics surveys and we conclude that the geophysical features could be satisfactorily explained assuming an extra-terrestrial projectile impact.

  15. 78 FR 6173 - Diana Del Grosso, Ray Smith, Joseph Hatch, Cheryl Hatch, Kathleen Kelley, Andrew Wilklund, and...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-29

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF TRANSPORTATION Surface Transportation Board Diana Del Grosso, Ray Smith, Joseph Hatch, Cheryl Hatch, Kathleen... Smith, Joseph Hatch, Cheryl Hatch, Kathleen Kelley, Andrew Wilklund, and Richard Kosiba...

  16. Medición de densidades medias de meteoritos: test del método de inmersión

    NASA Astrophysics Data System (ADS)

    Steren, G.

    Se evaluó una técnica simple para medir las densidades medias de meteoritos, basada en el Método de Arquímedes y que utiliza cuentas de vidrio de 40μ en lugar de un fluído esto presenta la ventaja de no ser intrusivo ni químicamente reactivo (D.Britt and G.Consolmagno, 1996, B.A.A.S.28,1106). El estudio, realizado en junio de este año por participantes de la VI Escuela de Verano del Observatorio del Vaticano, empleó 37 muestras de la colección del Observatorio del Vaticano, de las cuales 26 eran Condritas, 1 Pallasita y 1 Howardita; algunas de ellas ya habian sido estudiadas por otras técnicas aunque también se incluyeron muestras no estudiadas anteriormente.

  17. del Nido versus St. Thomas Cardioplegia Solutions: A Single-Center Retrospective Analysis of Post Cross-Clamp Defibrillation Rates.

    PubMed

    Buel, Shane T; Striker, Carrie Whittaker; O'Brien, James E

    2016-06-01

    There are many cardioplegia solutions currently in use for pediatric cardiopulmonary bypass (CPB). The most common being del Nido solution. Another common cardioplegia solution used for pediatric CPB is St. Thomas. In October 2014, Children's Mercy Kansas City changed from the use of modified St. Thomas to del Nido. This study compared rates of post cross-clamp fibrillation requiring defibrillation between del Nido solution and modified St. Thomas solution stratified by weight at Children's Mercy Kansas City. This retrospective study consisted of 394 patients who underwent cardiac surgery requiring cardioplegia between January 1, 2014 and July 31, 2015. The outcome measured was defibrillation upon cross-clamp removal. Statistical significance was determined using Fishers exact test with a two-sided significance level of .05. Incidence of defibrillation post cross-clamp removal was 4.4% in the del Nido group and 26.8% in the St. Thomas group (p < .0001). Analysis by weight stratifications displays a reduction in post cross-clamp defibrillation rates in groups using the del Nido solution. The 0- to 6-kg category had an incidence of fibrillation of 1.23% in the del Nido group and 17.5% in the St. Thomas group (p < .0003). The 6- to 15-kg category had an incidence of defibrillation of 1.82% in the del Nido group and 14% in the St. Thomas group (p < .0198). The 15- to 60-kg category had an incidence of defibrillation of 8.9% in the del Nido group and 61% in the St. Thomas group (p < .0001). The >60-kg category had an incidence of defibrillation of 16.7% in the del Nido group and 63% in the St. Thomas group (p < .0623). This study demonstrates a 6-fold decrease in the overall rate of defibrillation post cross-clamp removal between St. Thomas and del Nido cardioplegia solutions. Analyses of weight stratifications demonstrate a decrease in the rate of defibrillation post cross-clamp removal in all categories within the del Nido group. PMID:27578896

  18. Lumacaftor/ivacaftor combination for cystic fibrosis patients homozygous for Phe508del-CFTR.

    PubMed

    Zhang, W; Zhang, X; Zhang, Y H; Strokes, D C; Naren, A P

    2016-04-01

    Cystic fibrosis (CF) is a life-shortening inherited disease caused by the loss or dysfunction of the CF transmembrane conductance regulator (CFTR) channel activity resulting from mutations in the CFTR gene. Phe508del is the most prevalent mutation, with approximately 90% of all CF patients carrying it on at least one allele. Over the past two or three decades, significant progress has been made in understanding the pathogenesis of CF, and in the development of effective CF therapies. The approval of Orkambi® (lumacaftor/ivacaftor) marks another milestone in CF therapeutics development, which, with the advent of personalized medicine, could potentially revolutionize CF care and management. This article reviews the rationale, progress and future direction in the development of lumacaftor/ivacaftor combination to treat CF patients homozygous for the Phe508del-CFTR mutation. PMID:27252987

  19. A Neandertal mandible from the Cova del Gegant (Sitges, Barcelona, Spain).

    PubMed

    Daura, J; Sanz, M; Subirá, M E; Quam, R; Fullola, J M; Arsuaga, J L

    2005-07-01

    A human mandible from the site of Cova del Gegant is described here for the first time and compared with other Middle and Upper Pleistocene representatives of the genus Homo from Europe and Southwest Asia. The specimen was recovered from sediments which also yielded Mousterian stone tools and Pleistocene fauna. The preserved morphology of the mandible, particularly in the region of the mental foramen, clearly aligns it with the Neandertals, making the Cova del Gegant the only known site in Catalonia documenting diagnostic human skeletal remains in association with Middle Paleolithic stone tools. This represents an important new addition to the human fossil record from the Iberian Peninsula and joins the Bañolas mandible in documenting the course of human evolution in the northern Mediterranean region of Spain.

  20. Lumacaftor/ivacaftor combination for cystic fibrosis patients homozygous for Phe508del-CFTR.

    PubMed

    Zhang, W; Zhang, X; Zhang, Y H; Strokes, D C; Naren, A P

    2016-04-01

    Cystic fibrosis (CF) is a life-shortening inherited disease caused by the loss or dysfunction of the CF transmembrane conductance regulator (CFTR) channel activity resulting from mutations in the CFTR gene. Phe508del is the most prevalent mutation, with approximately 90% of all CF patients carrying it on at least one allele. Over the past two or three decades, significant progress has been made in understanding the pathogenesis of CF, and in the development of effective CF therapies. The approval of Orkambi® (lumacaftor/ivacaftor) marks another milestone in CF therapeutics development, which, with the advent of personalized medicine, could potentially revolutionize CF care and management. This article reviews the rationale, progress and future direction in the development of lumacaftor/ivacaftor combination to treat CF patients homozygous for the Phe508del-CFTR mutation.

  1. Highly ordered antigorite from Cerro del Almirez HP-HT serpentinites, SE Spain

    NASA Astrophysics Data System (ADS)

    Padrón-Navarta, J. A.; López Sánchez-Vizcaíno, V.; Garrido, C. J.; Gómez-Pugnaire, M. T.; Jabaloy, A.; Capitani, G. C.; Mellini, M.

    2008-11-01

    The Cerro del Almirez ultramafic massif offers an example of high pressure and high temperature antigorite serpentinites. A sharp antigorite-out isograd separates them from Chl-harzburgites, consisting of olivine + enstatite + chlorite. Antigorite is characterized by aluminium contents as high as 4 wt.% Al2O3. The microstructural study shows that, prior to the transformation, antigorite is exceptionally ordered and consists of the polysome m = 17. No polysomatic defect occurs in antigorite forming most of the Cerro del Almirez serpentinites. Close to the antigorite-out isograd, limited disorder features may occur, mainly as (001) twins, reaction rims and reduction of m down to 14-15. Here, local recrystallization phenomena lead to sporadic growth of large antigorite and chlorite crystals.

  2. PREVENCIÓN DEL VIH/SIDA EN LOS CIRCUITOS DE LEVANTE HSH: UNA ASIGNATURA PENDIENTE.

    PubMed

    Barreda, Victoria; Carballo-Dieguez, Alex; Marone, Rubén; Balán, Iván; Pando, María Ángeles; Avila, María Mercedes

    2010-12-01

    A partir de un relevamiento de tipo etnográfico, se describen lugares de encuentro de HSH en la Ciudad de Buenos Aires y sus prácticas sexuales. El reconocimiento de tales espacios, así como las características que asumen en ellos los encuentros sexuales entre los HSH, plantean obstáculos específicos en la adopción de comportamientos preventivos y, asimismo, generan nuevos desafíos para las actividades de prevención. Se plantean las dificultades y debates conceptuales que la misma categoría presenta, y sus consecuencias en el abordaje preventivo y teórico-metodológico para las ciencias sociales. Además, se proponen nuevos interrogantes acerca de los alcances y las limitaciones del modelo preventivo del VIH/Sida para HSH.

  3. Informe trata el descenso del cáncer y los tumores cerebrales

    Cancer.gov

    Los índices de mortalidad en los Estados Unidos de todos los cánceres en hombres y mujeres siguieron bajando entre 2003 y 2007, que es el período más reciente del que se disponen datos, según el último Informe Anual a la Nación sobre el Estado del Cáncer. El informe encuentra también que el índice general combinado de nuevos diagnósticos de cáncer en hombres y mujeres decreció un promedio un poco menos de 1% por año en el mismo período.

  4. Detection of super-soft emission in nova V339 Del

    NASA Astrophysics Data System (ADS)

    Page, K. L.; Osborne, J. P.; Kuin, N. P. M.; Woodward, C. E.; Schwarz, G. J.; Starrfield, S.; Shore, S. N.; Walter, F. M.

    2013-10-01

    Swift has been regularly observing the fourth LAT-detected classical nova (ATEL #5302) V339 Del (Nova Del 2013; PNV J20233073+2046041) since its outburst on 2013 August 14. Once optical loading had been correctly accounted for (ATel #5429), a real X-ray source was first detected on September 19. The XRT 0.3-10 keV X-ray count rate has been slowly rising since this time, from a value of (1.8 +0.7/-0.6)x10-3 count s-1 on September 19 to (7 +/- 2)x10-3 count s-1 on October 8 [these count rates are from grade 0 (single pixel) events only, to mitigate any residual optical loading effects].

  5. PREVENCIÓN DEL VIH/SIDA EN LOS CIRCUITOS DE LEVANTE HSH: UNA ASIGNATURA PENDIENTE.

    PubMed

    Barreda, Victoria; Carballo-Dieguez, Alex; Marone, Rubén; Balán, Iván; Pando, María Ángeles; Avila, María Mercedes

    2010-12-01

    A partir de un relevamiento de tipo etnográfico, se describen lugares de encuentro de HSH en la Ciudad de Buenos Aires y sus prácticas sexuales. El reconocimiento de tales espacios, así como las características que asumen en ellos los encuentros sexuales entre los HSH, plantean obstáculos específicos en la adopción de comportamientos preventivos y, asimismo, generan nuevos desafíos para las actividades de prevención. Se plantean las dificultades y debates conceptuales que la misma categoría presenta, y sus consecuencias en el abordaje preventivo y teórico-metodológico para las ciencias sociales. Además, se proponen nuevos interrogantes acerca de los alcances y las limitaciones del modelo preventivo del VIH/Sida para HSH. PMID:21874154

  6. A new species of Rhadinella (Serpentes: Colubridae) from the Sierra Madre del Sur of Guerrero, Mexico.

    PubMed

    Campillo, Gustavo; Dávila-Galavíz, Luis Fernando; Flores-Villela, Oscar; Campbell, Jonathan A

    2016-04-12

    We describe a new species of Rhadinella from the Sierra Madre del Sur of Guerrero, Mexico, a region where the genus was previously unknown. This diminutive species is a member of a group of snakes previously allocated in the Rhadinaea godmani group, and more recently transferred to the genus Rhadinella. These snakes may have conspicuous dark longitudinal striping on a pale brown to orange background or may have dark brown to blackish dorsal ground coloration, which mostly or completely obfuscates a pattern of longitudinal striping. The new species is mostly dark with barely discernible slightly paler or darker striping (depending on how striping is interpreted). The closest relative of the new species, on the basis of morphological similarities and biogeography, appears to be Rhadinella donaji which occurs to the east in the Sierra Madre del Sur of Oaxaca about 275 km from the type-locality of the new species.

  7. DEL RBC transfusion should be avoided in particular blood recipient in East Asia due to allosensitization and ineffectiveness*

    PubMed Central

    Shao, Chao-peng; Wang, Bao-yan; Ye, Shi-hui; Zhang, Wen-li; Xu, Hua; Zhuang, Nai-bao; Wu, Xiao-ying; Xu, Heng-gui

    2012-01-01

    Previously, both primary and secondary anti-D alloimmunizations induced by “Asian type” DEL (RHD1227A allele) were observed in two incidents. We investigated how often these alloimmunization events occur. The transfusions of any D-negative patients were investigated in the First Affiliated Hospital of Xi’an Jiaotong University Medical College, China, during the entire 2009. The antigens of D, C, c, E, and e were routinely serotyped. The “Asian type” DEL variant was genotyped and the RHD heterozygote was determined through two published methods. The changes in anti-D levels were monitored by the indirect antiglobulin test (IAT) and flow cytometry. Thirty D-negative transfused patients were included in the study. We focused on 11 recipients who were transfused with packed red blood cells (RBCs) from DEL donors at least one time. Of those 11 recipients, seven were anti-D negative before transfusion and four were anti-D positive (one patient with an autoantibody). One of the seven pre-transfusion anti-D negative patients produced a primary-response anti-D after being transfused with 400 ml of DEL blood twice. All four pre-transfusion antibody positive patients were not observed hemoglobin (Hb) levels increased, as expected after transfusions. Two patients had an increase in anti-D from 1:8 to 1:64 by IAT, which was also shown by flow cytometry. None of the patients experienced an acute hemolytic episode. Our data indicated that the primary anti-D induced by DEL transfusion or the secondary anti-D elevated by DEL in a truly D-negative patient might not be unusual. We suggest that a truly D-negative childbearing-aged woman should avoid DEL transfusion to protect her from primary anti-D allosensitization. In addition, anti-D positive recipients should also avoid DEL red cell transfusion due to the delayed hemolytic transfusion reaction (DHTR). PMID:23125084

  8. Violación del Principio de Equivalencia en Teorías con Dilatón de Cuerdas

    NASA Astrophysics Data System (ADS)

    Landau, S. J.; Sisterna, P. D.; Vucetich, H.

    Se estudian las violaciones al Principio de Equivalencia en Teorías con Dilatón de Cuerdas. En estos modelos, algunas de las constantes fundamentales dependen del espacio y del tiempo. Se muestra que los experimentos de caída libre no tienen aún precisión como para poner límites a los parámetros de la teoría.

  9. La reconstrucción del seno después de una mastectomía

    Cancer.gov

    Hoja informativa que describe la reconstrucción del seno (mama) después de una mastectomía. Contiene información sobre las opciones quirúrgicas, los cuidados de seguimiento y los exámenes de detección del cáncer de seno después de la reconstrucción.

  10. Estimaciones de Prevalencia del VIH por Género y Grupo de Riesgo en Tijuana, México: 2006

    PubMed Central

    Iñiguez-Stevens, Esmeralda; Brouwer, Kimberly C.; Hogg, Robert S.; Patterson, Thomas L.; Lozada, Remedios; Magis-Rodriguez, Carlos; Elder, John P.; Viani, Rolando M.; Strathdee, Steffanie A.

    2010-01-01

    OBJETIVO Estimar la prevalencia del VIH en adultos de 15-49 años de edad en Tijuana, México - en la población general y en subgrupos de riesgo en el 2006. METODOS Se obtuvieron datos demográficos del censo Mexicano del 2005, y la prevalencia del VIH se obtuvo de la literatura. Se construyó un modelo de prevalencia del VIH para la población general y de acuerdo al género. El análisis de sensibilidad consistió en estimar errores estándar del promedio-ponderado de la prevalencia del VIH y tomar derivados parciales con respecto a cada parámetro. RESULTADOS La prevalencia del VIH es 0.54%(N = 4,347) (Rango: 0.22%–0.86%, (N = 1,750–6,944)). Esto sugiere que 0.85%(Rango: 0.39%–1.31%) de los hombres y 0.22%(Rango: 0.04%–0.40%) de las mujeres podrían ser VIH-positivos. Los hombres que tienen sexo con hombres (HSH), las trabajadoras sexuales usuarias de drogas inyectables (MTS-UDI), MTS-noUDI, mujeres UDI, y los hombres UDI contribuyeron las proporciones más elevadas de personas infectadas por el VIH. CONCLUSIONES El número de adultos VIH-positivos entre subgrupos de riesgo en la población de Tijuana es considerable, marcando la necesidad de enforcar las intervenciones de prevención en sus necesidades específicas. El presente modelo estima que hasta 1 en cada 116 adultos podrían ser VIH-positivos. PMID:19685824

  11. The birth of oligodendrocytes in the anatomical and neuropathological literature: the seminal contribution of Pio del Rio-Hortega. 1921.

    PubMed

    Lassmann, Hans

    2012-01-01

    Comment on: del Río-Hortega P. Glia with very few processes (oligodendroglia). Clin Neuropathol. 2012; 31: 440-459, originally published in Archivos de Neurobiología. 1921; 2: 16-43 and del Río-Hortega P. Are the glia with very few processes homologous with Schwann cells? Clin Neuropathol. 2012; 31: 460-462, originally published in Bol de la Soc Esp de Biol. 1922; X: 25-28. PMID:22943958

  12. The CHEK2 del5395 is a founder mutation without direct effects for cancer risk in the latvian population

    PubMed Central

    Kalniete, D; Nakazawa-Miklasevica, M; Irmejs, A; Vjaters, E; Gardovskis, J; Miklasevics, E

    2015-01-01

    Abstract Our objective was to determine: 1) whether the checkpoint kinase 2 (CHEK2) del5395 (g.27417113-27422508 del, NC_000022.11) is a founder mutation in the Latvian population, 2) if there is an association between CHEK2 del5395 mutation and cancer risk, and 3) and whether the CHEK2 del5395 mutation impacts cancer predisposition in Chernobyl disaster liquidators (the civil and military personnel who were called upon to deal with consequences of the 1986 nuclear disaster) as well as geriatric populations. We recruited 438 breast cancer patients, 568 colorectal cancer patients, 399 ovarian cancer patients, 419 prostate cancer patients, 526 healthy blood donors, 480 Chernobyl disaster liquidators and 444 geriatric cancer-free participants. DNA samples were isolated from blood samples and subjected to multiplex polymerase chain reaction (PCR). The truncation of del5395 was estimated by fragment size of the multiplex PCR.All groups were compared to the healthy blood donors using Fisher’s exact test. All p values were two-sided and the odds ratios (OR) calculated by two-by-two table. In cancer groups, the del5395 mutation was most frequently observed in the ovarian cancer group (1.00%, OR = 1.32). In control groups, the del5395 mutation was most frequent (0.76%) in the healthy donors, which exceeded its frequency in the Chernobyl liquidators group and the geriatric group by 0.01 and 0.08%, respectively. For all groups, the OR appeared to be >1 only in ovarian cancer patients. However, OR rates showed no statistical significance in either cancer or control groups, with the p value fluctuating within the range of 0.39-1.00. The CHEK2 gene del5395 is a founder mutation in the Latvian population, which, however, does not have a direct impact on genetic predisposition toward colorectal, breast, ovarian and prostate cancer. PMID:27785394

  13. [The scientific progress of the "Clinica del Lavoro Luigi Devoto" as seen through the contents of the journal "La Medicina del Lavoro". ].

    PubMed

    Foà, V; Camerino, Donatella

    2003-01-01

    On occasion of the Centenary of the "Clinica del Lavoro Luigi Devoto", its researchers suggested that awareness of its historical identity and scientific development should constitute the basis for the future of the Institution. The directors of the Institute who have succeeded one to the other over the years have left a vivid report of the vast amount of work developed in several research fields and also of the original results achieved with significant impact on the scientific community and on society. Content analysis of "La Medicina del Lavoro" allowed us to shed light on strong bonds existing between manufacturing techniques, work organization and health, in the different political and social periods in which they developed. Many actions have been defined and several research subjects have been renewed (according to current demands and new methodological possibilities) between the past and the present, nevertheless many new approaches need to be taken in the fields of epidemiology, indoor air quality, ergophthalmology, muskuloskeletal disorders, environmental and molecular toxicology, and further research will be undertaken thanks to the potential of this discipline for the future. The aim of this report is also to express our thanks to all the medical and non-medical staff who have made their contribution over 100 years of engagement.

  14. Sanger Sequencing for BRCA1 c.68_69del, BRCA1 c.5266dup and BRCA2 c.5946del Mutation Screen on Pap Smear Cytology Samples.

    PubMed

    Lee, Sin Hang; Zhou, Shaoxia; Zhou, Tianjun; Hong, Guofan

    2016-02-08

    Three sets of polymerase chain reaction (PCR) primers were designed for heminested PCR amplification of the target DNA fragments in the human genome which include the site of BRCA1 c.68_69del, BRCA1 c.5266dup and BRCA2 c.5946del respectively, to prepare the templates for direct Sanger sequencing screen of these three founder mutations. With a robust PCR mixture, crude proteinase K digestate of the fixed cervicovaginal cells in the liquid-based Papanicolaou (Pap) cytology specimens can be used as the sample for target DNA amplification without pre-PCR DNA extraction, purification and quantitation. The post-PCR products can be used directly as the sequencing templates without further purification or quantitation. By simplifying the frontend procedures for template preparation, the cost for screening these three founder mutations can be reduced to about US $200 per test when performed in conjunction with human papillomavirus (HPV) assays now routinely ordered for cervical cancer prevention. With this projected price structure, selective patients in a high-risk population can be tested and each provided with a set of DNA sequencing electropherograms to document the absence or presence of these founder mutations in her genome to help assess inherited susceptibility to breast and ovarian cancer in this era of precision molecular personalized medicine.

  15. Pío del Río Hortega and the discovery of the oligodendrocytes

    PubMed Central

    Pérez-Cerdá, Fernando; Sánchez-Gómez, María Victoria; Matute, Carlos

    2015-01-01

    Pío del Río Hortega (1882–1945) discovered microglia and oligodendrocytes (OLGs), and after Ramón y Cajal, was the most prominent figure of the Spanish school of neurology. He began his scientific career with Nicolás Achúcarro from whom he learned the use of metallic impregnation techniques suitable to study non-neuronal cells. Later on, he joined Cajal’s laboratory. and Subsequently, he created his own group, where he continued to develop other innovative modifications of silver staining methods that revolutionized the study of glial cells a century ago. He was also interested in neuropathology and became a leading authority on Central Nervous System (CNS) tumors. In parallel to this clinical activity, del Río Hortega rendered the first systematic description of a major polymorphism present in a subtype of macroglial cells that he named as oligodendroglia and later OLGs. He established their ectodermal origin and suggested that they built the myelin sheath of CNS axons, just as Schwann cells did in the periphery. Notably, he also suggested the trophic role of OLGs for neuronal functionality, an idea that has been substantiated in the last few years. Del Río Hortega became internationally recognized and established an important neurohistological school with outstanding pupils from Spain and abroad, which nearly disappeared after his exile due to the Spanish civil war. Yet, the difficulty of metal impregnation methods and their variability in results, delayed for some decades the confirmation of his great insights into oligodendrocyte biology until the development of electron microscopy and immunohistochemistry. This review aims at summarizing the pioneer and essential contributions of del Río Hortega to the current knowledge of oligodendrocyte structure and function, and to provide a hint of the scientific personality of this extraordinary and insufficiently recognized man. PMID:26217196

  16. Segundo Catálogo Estelar del Hemisferio Sur con Astrolabio Fotoeléctrico PAII

    NASA Astrophysics Data System (ADS)

    Manrique, W. T.; Podestá, R. C.; Alonso, E.; Actis, E. V.; Pacheco, A. M.; Bustos, G.; Lizhi, L.; Zezhi, W.; Fanmiao, Z.; Hongqi, W.; Perdomo, R.

    Recordamos que entre el Observatorio Astronómico ``Félix Aguilar'', el Observatorio Astronómico de Beijing y el Observatorio Astronómico de La Plata, se ha convenido en desarrollar un Proyecto de Investigación conjunto, para la observación sistemática de estrellas en el Hemisferio Sur, con el objeto de la elaboración de un Catálogo Estelar Global utilizando un Astrolabio Fotoeléctrico PAII del Observatorio de Beijing, que ha sido usado con éxito en la República de China. En este trabajo se presenta el Segundo Catálogo Estelar del Hemisferio Sur, derivado de las observaciones realizadas con el PAII instalado en el OAFA, durante el períiodo Febrero de 1992 a Marzo de 1997. En este lapso se han observado mas de 400000 pasajes estelares, obteniéndose las correcciones Δ α y Δ δ de 5241 estrellas del FK4, FK5, FK5 Ext., SRS, CAMC y GC. Las precisiones medias son del orden de ± 3,2 ms en ascensión recta y ±0."057 en declinación. Rango de magnitudes : 2,0 a 11,5 Rango de declinaciones : -3o a -60o Epoca Media : 1994.9 Se analizan los residuos en función de la magnitud y tipo espectral, correcciones de grupo y frecuencia de distribución Δ α y Δ δ.

  17. Deep source model for Nevado del Ruiz Volcano, Colombia, constrained by interferometric synthetic aperture radar observations

    NASA Astrophysics Data System (ADS)

    Lundgren, P.; Samsonov, S. V.; López, C. M.; Ordoñez, M.

    2015-12-01

    Nevado del Ruiz (NRV) is part of a large volcano complex in the northern Andes of Colombia with a large glacier that erupted in 1985, generating a lahar killing over 23,000 people in the city of Armero and 2,000 people in the town of Chinchina. NRV is the most active volcano in Colombia and since 2012 has generated small eruptions, with no casualties, and constant gas and ash emissions. Interferometric synthetic aperture radar (InSAR) observations from ascending and descending track RADARSAT-2 data show a large (>20 km) wide inflation pattern apparently starting in late 2011 to early 2012 and continuing to the time of this study in early 2015 at a LOS rate of over 3-4 cm/yr (Fig. 1). Volcano pressure volume models for both a point source (Mogi) and a spheroidal (Yang) source find solutions over 14 km beneath the surface, or 10 km below sea level, and centered 10 km to the SW of Nevado del Ruiz volcano. The spheroidal source has a roughly horizontal long axis oriented parallel to the Santa Isabel - Nevado del Ruiz volcanic line and perpendicular to the ambient compressive stress direction. Its solution provides a statistically significant improvement in fit compared to the point source, though consideration of spatially correlated noise sources may diminish this significance. Stress change computations do not favor one model over the other but show that propagating dikes would become trapped in sills, leading to a more complex pathway to the surface and possibly explaining the significant lateral distance between the modeled sources and Nevado del Ruiz volcano.

  18. Pío del Río Hortega and the discovery of the oligodendrocytes.

    PubMed

    Pérez-Cerdá, Fernando; Sánchez-Gómez, María Victoria; Matute, Carlos

    2015-01-01

    Pío del Río Hortega (1882-1945) discovered microglia and oligodendrocytes (OLGs), and after Ramón y Cajal, was the most prominent figure of the Spanish school of neurology. He began his scientific career with Nicolás Achúcarro from whom he learned the use of metallic impregnation techniques suitable to study non-neuronal cells. Later on, he joined Cajal's laboratory. and Subsequently, he created his own group, where he continued to develop other innovative modifications of silver staining methods that revolutionized the study of glial cells a century ago. He was also interested in neuropathology and became a leading authority on Central Nervous System (CNS) tumors. In parallel to this clinical activity, del Río Hortega rendered the first systematic description of a major polymorphism present in a subtype of macroglial cells that he named as oligodendroglia and later OLGs. He established their ectodermal origin and suggested that they built the myelin sheath of CNS axons, just as Schwann cells did in the periphery. Notably, he also suggested the trophic role of OLGs for neuronal functionality, an idea that has been substantiated in the last few years. Del Río Hortega became internationally recognized and established an important neurohistological school with outstanding pupils from Spain and abroad, which nearly disappeared after his exile due to the Spanish civil war. Yet, the difficulty of metal impregnation methods and their variability in results, delayed for some decades the confirmation of his great insights into oligodendrocyte biology until the development of electron microscopy and immunohistochemistry. This review aims at summarizing the pioneer and essential contributions of del Río Hortega to the current knowledge of oligodendrocyte structure and function, and to provide a hint of the scientific personality of this extraordinary and insufficiently recognized man. PMID:26217196

  19. Mach, Thirring & Lense, Gödel getting dizzy in space-time

    NASA Astrophysics Data System (ADS)

    Embacher, Franz

    2007-11-01

    Contrary to Newton's concept of inertia, general relativity predicts an influence of rotating matter on the structure of space and time. Anticipated by Ernst Mach, effects of this type have first been derived by Hans Thirring and Josef Lense. Almost ninety years later, we face their experimental verification. An even more dramatic scenario is provided by Kurt Gödel's cosmological model, in which nearby observers rotate with respect to each other and are free to travel to their own past.

  20. Juvenile rheumatoid arthritis and del(22q11) syndrome: a non-random association.

    PubMed Central

    Verloes, A; Curry, C; Jamar, M; Herens, C; O'Lague, P; Marks, J; Sarda, P; Blanchet, P

    1998-01-01

    Del(22q11) is a common microdeletion syndrome with an extremely variable phenotype. Besides classical manifestations, such as velocardiofacial (Shprintzen) or DiGeorge syndromes, del(22q11) syndrome may be associated with unusual but probably causally related anomalies that expand its phenotype and complicate its recognition. We report here three children with the deletion and a chronic, erosive polyarthritis resembling idiopathic cases of juvenile rheumatoid arthritis (JRA). Patient 1, born in 1983, initially presented with developmental delay, facial dysmorphism, velopharyngeal insufficiency, and severe gastro-oesophageal reflux requiring G tube feeding. From the age of 3 years, he developed JRA, which resulted in severe restrictive joint disease, osteopenia, and platyspondyly. Patient 2, born in 1976, had tetralogy of Fallot and peripheral pulmonary artery stenosis. She developed slowly, had mild dysmorphic facial features, an abnormal voice, and borderline intelligence. JRA was diagnosed at the age of 5 years. The disorder followed a subacute course, with relatively mild inflammatory phenomena, but an extremely severe skeletal involvement with major osteopenia, restrictive joint disease (bilateral hip replacement), and almost complete osteolysis of the carpal and tarsal bones with phalangeal synostoses, leading to major motor impairment and confinement to a wheelchair. Patient 3, born in 1990, has VSD, right embryo-toxon, bifid uvula, and facial dysmorphism. She developed JRA at the age of 1 year. She is not mentally retarded but has major speech delay secondary to congenital deafness inherited from her mother. In the three patients, a del(22q11) was shown by FISH analysis. These observations, and five other recently published cases, indicate that a JRA-like syndrome is a component of the del(22q11) spectrum. The deletion may be overlooked in those children with severe, chronic inflammatory disorder. Images PMID:9832043

  1. [Programme review of somatropin deficit in pediatrics at the Hospital Universitario Virgen del Rocío].

    PubMed

    Lavaredas, A; de la Puerta, R; Álvarez del Vayo, C

    2013-01-01

    Objetivo: Elaborar una revisión del programa de déficit de somatropina aplicado en pediatría en el Hospital Universitario Virgen del Rocío, utilizando dos grupos de pacientes, los diagnosticados con déficit de esta hormona y los nacidos pequeños para edad gestacional, con la intención de evaluar su efectividad en el primer año de tratamiento. Método: Realización de un estudio retrospectivo de la cohorte de pacientes en tratamiento con la hormona del crecimiento bajo los diagnósticos mencionados, con metodología observacional y transversal, a los cuales se aplicó un análisis estadístico con el programa Statistical Package for Social Sciences®. Resultados: Tras inicio del tratamiento la velocidad de crecimiento y la talla aumentaron y la edad ósea se aproximó a la edad cronológica. En los dos grupos tratados, en el primer año de tratamiento fueron los pacientes del sexo femenino con edad comprendida entre los 0 a 12 años con déficit de la hormona del crecimiento que respondieron mejor a la terapéutica establecida. Conclusiones: Pudimos observar que el tratamiento instituido se presentó altamente efectivo en ambos grupos de pacientes, permitiendo obtener un aumento favorable de estatura.

  2. Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809

    PubMed Central

    Van Goor, Fredrick; Hadida, Sabine; Grootenhuis, Peter D. J.; Burton, Bill; Stack, Jeffrey H.; Straley, Kimberly S.; Decker, Caroline J.; Miller, Mark; McCartney, Jason; Olson, Eric R.; Wine, Jeffrey J.; Frizzell, Ray A.; Ashlock, Melissa; Negulescu, Paul A.

    2011-01-01

    Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator (CFTR) gene that impair the function of CFTR, an epithelial chloride channel required for proper function of the lung, pancreas, and other organs. Most patients with CF carry the F508del CFTR mutation, which causes defective CFTR protein folding and processing in the endoplasmic reticulum, resulting in minimal amounts of CFTR at the cell surface. One strategy to treat these patients is to correct the processing of F508del-CFTR with small molecules. Here we describe the in vitro pharmacology of VX-809, a CFTR corrector that was advanced into clinical development for the treatment of CF. In cultured human bronchial epithelial cells isolated from patients with CF homozygous for F508del, VX-809 improved F508del-CFTR processing in the endoplasmic reticulum and enhanced chloride secretion to approximately 14% of non-CF human bronchial epithelial cells (EC50, 81 ± 19 nM), a level associated with mild CF in patients with less disruptive CFTR mutations. F508del-CFTR corrected by VX-809 exhibited biochemical and functional characteristics similar to normal CFTR, including biochemical susceptibility to proteolysis, residence time in the plasma membrane, and single-channel open probability. VX-809 was more efficacious and selective for CFTR than previously reported CFTR correctors. VX-809 represents a class of CFTR corrector that specifically addresses the underlying processing defect in F508del-CFTR. PMID:21976485

  3. A Precambrian cratonic block in the west-central Chihuahua - The Sierra del Nido cratonic block

    SciTech Connect

    Goodell, P.C. . Dept. of Geological)

    1993-02-01

    Precambrian rocks in west-central Chihuahua have been recognized by Denison (1969) and Mauger et al. (1983), on the basis of radiometric dating. The rocks are rhyolite clasts, and an allucthonous block, respectively, however their source direction and vergence can be measured. They point back to and are on the edge of a large, uniform, negative Bouguer gravity anomaly, having values greater than 200 milligals. The isotopic geochemical character of several Tertiary felsic fields within this anomalous are has been determined, and initial strontium isotopic ratios are all greater than 0.7055. Outside the anomalous area these ratios are lower, and Basin and Range extension tectonism is more evident. It is proposed that a Precambrian cratonic block, the Sierra del Nido, is present in the crust in west-central Chihuahua. It is reasonable to propose that it was decreted from North America during a Precambrian extensional (1.1. By ) event, from somewhere along the Arizona Transition Zone-Texas Linament region. The Sierra del Nido Block is separated form the ATZ-TL by a region of disrupted craton and extended crust, the Basin and Range Province. Implications of the pressure of the Sierra del Nido Block on other regional tectonic events will be discussed.

  4. Proteolytic effect of Cynara cardunculus rennet for use in the elaboration of 'Torta del Casar' cheese.

    PubMed

    Ordiales, Elena; Benito, Maria José; Martin, Alberto; Fernández, Margarita; Hernández, Alejandro; de Guia Córdoba, Maria

    2013-11-01

    The purpose of this work was to analyse the influence of rennet from different Cynara cardunculus plants, selected for its clotting and proteolytic activity on caseins, on the characteristics of manufactured 'Torta del Casar' cheeses. After classifying the cardoon according to proteolytic activity into five groups of greater or lesser activity, 16 batches of cheeses were made with rennet derived from different wild cardoon plants. We observed a major development of the proteolysis during ripening leading to the generation of non-protein nitrogen compounds. Especially noteworthy was the relationship of amino acid nitrogen (AN) generation with rennet clotting activity after 24 h of maceration, and the fact that the production of biogenic amines was not related to the proteolytic activity of the rennet. The activities of the rennet observed 'in vitro' were also developed 'in vivo' in the cheeses, with the different rennets used affecting the final sensory characteristics of cheeses. The rennet with high clotting activity after 24 h of maceration was positively correlated with the creaminess, viscosity, and acceptability of the cheese. However, the high proteolytic activity rennet negatively influenced the acidity, bitterness, and creaminess parameters. Therefore the most appropriate cardoons for making this cheese are those with higher clotting activities and moderate proteolytic activities especially on β-casein. The use of controlled and characterised cardoons in the manufacturing process of Torta del Casar is fundamental to obtaining the homogeneous product demanded by the Torta del Casar Registry of the Protected Designation of Origin.

  5. Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS.

    PubMed

    Krönke, Jan; Fink, Emma C; Hollenbach, Paul W; MacBeth, Kyle J; Hurst, Slater N; Udeshi, Namrata D; Chamberlain, Philip P; Mani, D R; Man, Hon Wah; Gandhi, Anita K; Svinkina, Tanya; Schneider, Rebekka K; McConkey, Marie; Järås, Marcus; Griffiths, Elizabeth; Wetzler, Meir; Bullinger, Lars; Cathers, Brian E; Carr, Steven A; Chopra, Rajesh; Ebert, Benjamin L

    2015-07-01

    Lenalidomide is a highly effective treatment for myelodysplastic syndrome (MDS) with deletion of chromosome 5q (del(5q)). Here, we demonstrate that lenalidomide induces the ubiquitination of casein kinase 1A1 (CK1α) by the E3 ubiquitin ligase CUL4-RBX1-DDB1-CRBN (known as CRL4(CRBN)), resulting in CK1α degradation. CK1α is encoded by a gene within the common deleted region for del(5q) MDS and haploinsufficient expression sensitizes cells to lenalidomide therapy, providing a mechanistic basis for the therapeutic window of lenalidomide in del(5q) MDS. We found that mouse cells are resistant to lenalidomide but that changing a single amino acid in mouse Crbn to the corresponding human residue enables lenalidomide-dependent degradation of CK1α. We further demonstrate that minor side chain modifications in thalidomide and a novel analogue, CC-122, can modulate the spectrum of substrates targeted by CRL4(CRBN). These findings have implications for the clinical activity of lenalidomide and related compounds, and demonstrate the therapeutic potential of novel modulators of E3 ubiquitin ligases. PMID:26131937

  6. Pampa del Palo: an anomalous composite marine terrace on the uprising coast of southern Peru

    NASA Astrophysics Data System (ADS)

    Ortlieb, L.; Zazo, C.; Goy, J. L.; Dabrio, C.; Macharé, J.

    1996-11-01

    Quaternary sediments along the southern Perúvian coast occur as staircase terraces of coastal and shallow-marine deposits in response to continuous uplift related to the active boundary between the Nazca and South-American plates. However, near ILO (in the same coastal stretch) the emergent Pampa del Palo terrace consists of a relatively-thick, vertical stack of shallow-marine, coastal and lagoonal deposits that indicate a rather different geodynamic behaviour. Coastal deposits are correlatable with the successive marine highstands of isotopic stages 7 (?) and 5 (substages 5e and 5c). Combining aerial photo-interpretation, geomorphological mapping, sedimentological analysis, chronostratigraphical data, and structural observations, the Pampa del Palo feature is interpreted as a faulted block that moved independently of the remaining southern Peruvian coast and, for some time between the end of Middle Pleistocene (before ca. 220 ka) and the early Late Pleistocene (ca. 120 ka), it rose more slowly or was even down-faulted relative to the rest of the southern Peruvian margin. The independent block movements ceased after substage 5e, when the Pampa del Palo "terrace" was incorporated into the regional uplift of the area. Since ca. 100 ka, measured uplift rates in the Ilo area amounted up to {160 mm}/{10 3y } when the area has been affected by a few active, NE-SE trending faults only.

  7. Digitalización de diapositivas del Sol en H α

    NASA Astrophysics Data System (ADS)

    Missio, H.; Montenegro, C.; Montenegro, R.

    El objetivo de este trabajo ha sido el de obtener imágenes digitalizadas de las diapositivas tomadas del Sol en luz de hidrógeno de la línea correspondiente a Hα, y de esta manera llegar a convertir las mismas a un archivo digital para poder ser tratadas luego por computadora y poder contabilizar con exactitud, mediante un programa adecuado para tal fin, las zonas activas del Sol en la imagen digitalizada. En principio, para llegar a esto se pensó en la utilización de medios accesibles, y como detector se utilizó un fototransistor ubicado dentro de un soporte rectangular sobre dos ejes de desplazamiento X e Y. Se han obtenido con este procedimiento imágenes de buena calidad, construídas a partir de tres datos digitalizados en cada barrido que aportan la posición X e Y y la intensidad del pixel en ese punto indicada en 255 tonos de grises.

  8. Filaggrin mutations p.R501X and c.2282del4 in ichthyosis vulgaris.

    PubMed

    Gruber, Robert; Janecke, Andreas R; Fauth, Christine; Utermann, Gerd; Fritsch, Peter O; Schmuth, Matthias

    2007-02-01

    Ichthyosis vulgaris (IV) is the most common hereditary disorder of cornification in humans, characterized by generalized fine scaling of the skin, palmar hyperlinearity with or without keratosis pilaris and atopy. Recently, the molecular basis of IV was ascribed to loss-of-function mutations in the gene encoding filaggrin (FLG), namely p.R501X and c.2282del4. Homozygotes and compound heterozygotes were severely affected whereas heterozygotes showed mild disease or were asymptomatic, suggesting semidominant inheritance with incomplete penetrance in heterozygotes. We report the presence of FLG mutations in 15 out of 21 IV patients with a marked generalized scaling phenotype, including eight affected members of a four-generation family. In this group of patients not only homozygous and compound heterozygous, but also heterozygous patients for p.R501X and c.2282del4 display a pronounced phenotype, whereas in none of six individuals these two mutations were detectable despite decreased filaggrin expression on immunohistochemistry in two patients, indicating that other mutations in FLG and/or in other genes remain to be identified. In contrast, two additional p.R501X heterozygotes from the extended family are asymptomatic. In a control population from west-Austria a combined p.R501X and c.2282del4 carrier frequency of 6/110 (5.45%) was observed. We confirm that these FLG variants are common, but our results point to the existence of additional modifiers.

  9. Traffic circulation study and long-range plan for Del Rio. Interim research report

    SciTech Connect

    Weissmann, A.J.; Islam, R.

    1996-03-01

    A 1992 report to Congress, pursuant to Intermodal Surface Transportation Efficiency Act (ISTEA) sections 1089 and 6015, acknowledges that Texas serves a disproportionate share of the U.S.-Mexico international trade, and, accordingly, recommends the development of federal-aid program options to improve transportation infrastructure related to international trade. In order to take advantage of this recommendation, border states must monitor their transborder traffic demand and develop traffic circulation plans for their border cities. This report presents a 25-year traffic circulation plan for the City of Del Rio, Texas. The plan includes recommendations for increasing roadway capacity, adding left-turn lanes, building new routes to relieve congestion, and adding international thoroughfares. It also includes a comprehensive analysis of a transborder traffic in Del Rio, as well as of international thoroughfares between Cuidad Acuna and Del Rio. The recommendations take into account input from TxDOT personnel, City officials, border inspectors, international bridge managers, and several Mexican officials. The recommendations and schedules discussed in this report can assist TxDOT not only in planning land transport infrastructure, but also in alleviating problems associated with additional highway capacity, pavement rehabilitation, signalization, and right-of-way.

  10. El diseño final del espectrógrafo de banco (EBASIM) para CASLEO

    NASA Astrophysics Data System (ADS)

    Simmons, J.; Levato, H.

    Utilizando el código de óptica ACCOS V se ha finalizado el diseño del espectrógrafo de banco para CASLEO. En una comunicación anterior habíamos indicado que utilizaríamos un colimador de 150 mm de diámetro con un radio de curvatura de 1540 mm. Para el espejo cámara, que tiene un diámetro de 200 mm, el radio de curvatura es de 1200 mm, ambos radios con una tolerancia no mayor a los 3 mm. En la presente, se informa sobre los detalles finales del cálculo del espectrógrafo que incluye el cómputo para 5 longitudes de onda diferentes y alrededor de 100 rayos. En todos los casos el 75 % de energía está dentro de un diámetro de 13 micrones. El diseño ha sido probado entre 3500 Å hasta 9000 Å con resultados satisfactorios.

  11. Observaciones del disco solar y de una protuberancia quiescente en radiación ultravioleta

    NASA Astrophysics Data System (ADS)

    Cirigliano, D.; Vial, J.-C.; Rovira, M.

    Observaciones del disco solar y de una protuberancia quiescente en el rango de longitudes de onda ultravioleta fueron obtenidas con el instrumento CDS (Coronal Diagnostic Spectrograph) y SUMER (Solar Ultraviolet Measurements of emitted radiation) a bordo de la sonda SOHO. El propósito es investigar las velocidades macroscópicas de varias especies metálicas que se observan tanto en el disco solar como en el plasma de las protuberancias. Para calcular las velocidades del disco solar aplicamos una técnica mixta para modelar la distribución de estructuras en UV en el Sol quieto. Las velocidades macroscópicas en las protuberancias se calcularon a partir de los corrimientos Doppler en cada línea espectral y luego se tomaron las del disco solar como referencia. Obtuvimos valores absolutos para las velocidades macroscópicas entre 5 y 40 km/seg. También detectamos comportamientos diferentes en las velocidades de las protuberancias en el centro con respecto a los bordes.

  12. Heat flow and thermal processes in the Jornada delMuerto, New Mexico

    NASA Technical Reports Server (NTRS)

    Reiter, M.

    1985-01-01

    Most heat flow data in rifts are uncertain largely because of hydrologic disturbances in regions of extensive fracturing. Estimates of heat flow in deep petroleum tests within a large basin of the Rio Grande rift, which has suffered little syn-rift fracturing, may begin to provide clearer insight into the relationships between high heat flow and crustal thinning processes. The Jornada del Muerto is a large basin located in the Rio Grande rift of south central New Mexico. The region of interest within the Jornada del Muerto is centered about 30 km east of the town of Truth or Consequences, and is approximately 60 km north-south by 30 km east-west. High heat flows are estimated for the region. Values increase from about 90 mWm(-2) in the northern part of the study area to about 125 mWm(-2) in the southern part. These high heat flows are rather enigmatic because in the immediate vicinities of the sites there is little evidence of Cenozoic volcanism or syn-rift extensional tectonics. It is suggested that the geothermal anomaly in the southern Jornada del Muerto (approx. 125 to approx. 95 mWm(-2) results from some type of mass movement-heat transfer mechanism operating in the crust just below the elastic layer. This conclusion is consistent with the geologic and geophysical data which describe a thin crust, apparently devoid of features indicative of extensional-tectonics in the upper part of the lastic crust.

  13. Campano-Maastrichtian foraminifera from onshore sediments in the Rio del Rey Basin, Southwest Cameroon

    NASA Astrophysics Data System (ADS)

    Njoh, Oliver Anoh; Victor, Obiosio; Christopher, Agyingi

    2013-03-01

    Campanian-Maastrichtian marine sediments outcrop in five genetically linked sedimentary basins along the West African coast in the Gulf of Guinea, from the Douala Basin in Cameroon to the Anambra Basin in Nigeria. These sediments in the more centrally located Rio del Rey Basin have been the least studied. Therefore, the geologic history of this region has merely been speculative. The Rio del Rey Basin like the adjacent Niger Delta is producing hydrocarbon from the offshore Tertiary sedimentary interval in which all studies have been focused, neglecting the onshore Cretaceous sediments. Outcrops in the basin are rare, small and highly weathered. Samples from some of these sediments have yielded a few Planktonic and dominantly benthonic foraminiferal assemblages. The long-ranging heterohelix and hedbergellids characterized the planktics while the species Afrobolivina afra which is a well known diagnostic taxon for Campanian-Maastrichtian sediments in West African basins clearly dominate the benthic assemblage. Its occurrence in association with other Upper Cretaceous forms such as Bolivina explicata, Praebulimina exiqua, Gabonita lata, Ammobaculites coprolithiformis amongst others, formed the basis on which this age was assigned to the sediments sampled from the Rio del Rey Basin. Hence, this work has undoubtedly established the much needed link in this regional geologic history and correlates these sediments with the Logbaba and Nkporo Formations in the Douala Basin in Cameroon and the southeastern Nigerian Sedimentary Basins. Thus, these units were all deposited during this same geologic period and probably controlled by the same geologic event.

  14. Relevamiento total del hemisferio sur celeste en la frecuencia de 1420 MHz

    NASA Astrophysics Data System (ADS)

    Bava, J. A.; Colomb, F. R.; Hurrel, E.; Larrarte, J. J.; Sanz, A. J.; Testori, J. C.; Reich, P.; Reich, W.; Wielebinski, R.

    En el presente artículo se describe el relevamiento del cielo en el Hemisferio Sur Celeste en la frecuencia de 1420 MHz para declinaciones δ<= -19o realizado con la Antena II de 30 metros de diámetro del IAR. Este relevamiento posee igual sensibilidad (3xr.m.s=50 mK) que el realizado en el Hemisferio Norte con el radiotelescopio de 25 metros de Stockert de la Universidad de Bonn, operado por el Max-Planck Institute für Radioastronomie ( Reich W., 1982, A&ASS 48, 219; Reich P. and Reich W., 1986, A&ASS 63, 205). Con los datos obtenidos por ambos radiotelescopios se posee una base de datos de todo el cielo en esta frecuencia. En esta publicación presentamos los detalles del sistema receptor, técnicas de observación y reducción de datos, calibración y discusión de los errores en los resultados.

  15. Lenalidomide for myelodysplastic syndromes with del(5q): how long should it last?

    PubMed

    Vozella, Federico; Latagliata, Roberto; Carmosino, Ida; Volpicelli, Paola; Montagna, Chiara; Romano, Angela; Roberto, Amanda; Finsinger, Paola; Mancini, Marco; Breccia, Massimo; Oliva, Esther; Oliva, Esther

    2015-03-01

    Lenalidomide induces in patients with myelodysplastic syndrome (MDS) and del(5q) erythroid and cytogenetic response rates as high as 75% and 50%, respectively. It is still unclear, however, how long lenalidomide treatment should be continued and whether or not the drug could be interrupted. To assess the feasibility of lenalidomide discontinuation, we revised a cohort of 16 low-risk MDS patients with del(5q) treated at our institute in a phase II multicentric Italian study. Among the 12 responding patients, four discontinued lenalidomide while in complete response. All four patients needed during treatment a permanent lenalidomide reduction from 10 to 5 mg/day because of haematological toxicity (three patients) or grade 3 muscular and bone pain (one patient). At lenalidomide discontinuation after 16, 20, 27 and 20 months from the start, respectively, all four patients were in complete hematologic response and three forth in complete cytogenetic response. Three patients are still in response after 36, 30 and 20 months from lenalidomide discontinuation, respectively: The remaining patient relapsed after 20 months, and she is now receiving a new course of lenalidomide. In conclusion, long-lasting remissions are achievable in MDS patients with del(5q) in complete response after lenalidomide discontinuation. PMID:25950027

  16. Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS

    PubMed Central

    Hollenbach, Paul W.; MacBeth, Kyle J.; Hurst, Slater N.; Udeshi, Namrata D.; Chamberlain, Philip P.; Mani, D.R.; Man, Hon Wah; Gandhi, Anita K.; Svinkina, Tanya; Schneider, Rebekka K.; McConkey, Marie; Järås, Marcus; Griffiths, Elizabeth; Wetzler, Meir; Bullinger, Lars; Cathers, Brian E.; Carr, Steven A.; Chopra, Rajesh; Ebert, Benjamin L.

    2015-01-01

    Summary Lenalidomide is a highly effective treatment for myelodysplastic syndrome (MDS) with deletion of chromosome 5q (del(5q)). Here, we demonstrate that lenalidomide induces the ubiquitination of casein kinase 1A1 (CK1α) by the CRL4CRBN E3 ubiquitin ligase, resulting in CK1α degradation. CK1α is encoded by a gene within the common deleted region for del(5q) MDS and haploinsufficient expression sensitizes cells to lenalidomide therapy, providing a mechanistic basis for lenalidomide's therapeutic window in del(5q) MDS. We found that mouse cells are resistant to lenalidomide but that changing a single amino acid in mouse Crbn to the corresponding human residue enables lenalidomide-dependent degradation of CK1α. We further demonstrate that minor side chain modifications in thalidomide and a novel analogue, CC-122, can modulate the spectrum of substrates targeted by CRL4CRBN. These findings have implications for the clinical activity of lenalidomide and related compounds and demonstrate the therapeutic potential of novel modulators of E3 ubiquitin ligases. PMID:26131937

  17. Variation in mangrove forest structure and sediment characteristics in Bocas del Toro, Panama

    USGS Publications Warehouse

    Lovelock, C.E.; Feller, Ilka C.; McKee, K.L.; Thompson, R.

    2005-01-01

    Mangrove forest structure and sediment characteristics were examined in the extensive mangroves of Bocas del Toro, Republic of Panama. Forest structure was characterized to determine if spatial vegetation patterns were repeated over the Bocas del Toro landscape. Using a series of permanent plots and transects we found that the forests of Bocas del Toro were dominated by Rhizophora mangle with very few individuals of Avicennia germinans and Laguncularia racemosa. Despite this low species diversity, there was large variation in forest structure and in edaphic conditions (salinity, concentration of available phosphorus, Eh and sulphide concentration). Aboveground biomass varied 20-fold, from 6.8 Mg ha-1 in dwarf forests to 194.3 Mg ha-1 in the forests fringing the land. But variation in forest structure was predictable across the intertidal zone. There was a strong tree height gradient from seaward fringe (mean tree height 3.9 m), decreasing in stature in the interior dwarf forests (mean tree height 0.7 m), and increasing in stature in forests adjacent to the terrestrial forest (mean tree height 4.1 m). The predictable variation in forest structure emerges due to the complex interactions among edaphic and plant factors. Identifying predictable patterns in forest structure will aid in scaling up the ecosystem services provided by mangrove forests in coastal landscapes. Copyright 2005 College of Arts and Sciences.

  18. Mitochondrial DNA diversity of feral pigs from Karukinka Natural Park, Tierra del Fuego Island, Chile.

    PubMed

    Aravena, P; Skewes, O; Gouin, N

    2015-04-28

    Control or eradication of exotic species is one of the greatest challenges facing biodiversity and ecosystem conservation. Domestic pigs (Sus scrofa domestica) were released and became feral in the southern region of Chilean Tierra del Fuego Island in the 1900s. Currently, they inhabit part of Karukinka Natural Park, an area of global conservation concern. To gain insight into the control of this invasive species, we analyzed genetic variation in the mitochondrial DNA control region to determine the origin and population subdivision of feral pigs in Tierra del Fuego. Sequences from a sample of 42 feral pigs, 10 domestic pigs from local farms, and references from other countries and commercial breeds revealed 2 highly differentiated populations, 1 in the western and the other in the eastern area of the park, each harboring a different haplotype, suggesting no connectivity between populations. Comparison of these haplotypes with reference sequences from other countries and commercial breeds indicated that feral pigs from Chilean Tierra del Fuego are of European origin, very likely from 2 separate introduction events. The haplotype found in the western feral population was also identified in domestic pigs from a farm. This raises concerns regarding the possible connectivity between stocks from local farms and the wild population. Based on these results, we recommend the development of strategies for controlling the population of this invasive species in Karukinka Natural Park.

  19. Moléculas orgánicas obtenidas en simulaciones experimentales del medio interestelar.

    NASA Astrophysics Data System (ADS)

    Muñoz-Caro, Guillermo Manuel

    Las nubes moleculares son regiones de formación de estrellas, con temperaturas cinéticas entre 10-50 K y densidades de 103-106 átomos cm-3. Su materia está formada por gas y polvo interestelar. Estas partículas de polvo están cubiertas por una fina capa de hielo, de unos 0.01 μm, que contiene H2O y a menudo CO, CO2, CH3OH y NH3. El hielo es presumiblemente irradiado por fotones ultravioleta y rayos cósmicos en las zonas poco profundas de las nubes moleculares y las regiones circunestelares. En un sistema de vacío, P ˜ 10-7 mbar, simulamos la deposición de hielo a partir de 10 K y la irradiación ultravioleta por medio de una lámpara de descarga de hidrógeno activada con microondas. La evolución del hielo se observa por medio de un espectrómetro infrarrojo. De este modo es posible determinar la composición del hielo observado en el medio interestelar y predecir la presencia de moléculas aún no detectadas en el espacio, que han sido producto del procesamiento del hielo en nuestros experimentos. También es posible calentar el sistema hasta temperatura ambiente para sublimar el hielo depositado. Cuando el hielo ha sido previamente irradiado, se observa un residuo compuesto por moléculas orgánicas complejas, algunas prebióticas, como varios ácidos carboxílicos, aminas, amidas, ésteres y en menor proporción moléculas heterocíclicas y aminoácidos. Algunas de estas moléculas podrían detectarse en estado gaseoso por medio de observaciones milimétricas y de radio. También podrían estar presentes en el polvo cometario, cuyo análisis químico está planeado por las misiones Stardust y Rosetta. Mientras tanto, nuestro grupo está llevando a cabo el análisis de partículas de polvo interplanetario (IDPs), algunas de las cuales pueden ser de origen cometario. Al igual que ocurre con los productos obtenidos por irradiación del hielo en nuestros experimentos, algunas IDPs son ricas en material orgánico que contiene oxígeno.

  20. Furia y Muerte: Los Bandidos Chicanos (Fury and Death: The Chicano Bandits). Monograph No. 4, Aztlan Publications.

    ERIC Educational Resources Information Center

    Castillo, Pedro, Ed.; Camarillo, Albert, Ed.

    In the latter half of the nineteenth century five Chicano "bandidos" became prominant in Southwestern history. These "social bandits" were viewed by the dominant Anglo culture as outlaws and criminals; their people saw them as heroes and fighters for justice. Anglos had invaded Northern Mexico, disrupted the existing society, and established a…

  1. Restoration of CFTR function in patients with cystic fibrosis carrying the F508del-CFTR mutation.

    PubMed

    De Stefano, Daniela; Villella, Valeria R; Esposito, Speranza; Tosco, Antonella; Sepe, Angela; De Gregorio, Fabiola; Salvadori, Laura; Grassia, Rosa; Leone, Carlo A; De Rosa, Giuseppe; Maiuri, Maria C; Pettoello-Mantovani, Massimo; Guido, Stefano; Bossi, Anna; Zolin, Anna; Venerando, Andrea; Pinna, Lorenzo A; Mehta, Anil; Bona, Gianni; Kroemer, Guido; Maiuri, Luigi; Raia, Valeria

    2014-01-01

    Restoration of BECN1/Beclin 1-dependent autophagy and depletion of SQSTM1/p62 by genetic manipulation or autophagy-stimulatory proteostasis regulators, such as cystamine, have positive effects on mouse models of human cystic fibrosis (CF). These measures rescue the functional expression of the most frequent pathogenic CFTR mutant, F508del, at the respiratory epithelial surface and reduce lung inflammation in Cftr(F508del) homozygous mice. Cysteamine, the reduced form of cystamine, is an FDA-approved drug. Here, we report that oral treatment with cysteamine greatly reduces the mortality rate and improves the phenotype of newborn mice bearing the F508del-CFTR mutation. Cysteamine was also able to increase the plasma membrane expression of the F508del-CFTR protein in nasal epithelial cells from F508del homozygous CF patients, and these effects persisted for 24 h after cysteamine withdrawal. Importantly, this cysteamine effect after washout was further sustained by the sequential administration of epigallocatechin gallate (EGCG), a green tea flavonoid, both in vivo, in mice, and in vitro, in primary epithelial cells from CF patients. In a pilot clinical trial involving 10 F508del-CFTR homozygous CF patients, the combination of cysteamine and EGCG restored BECN1, reduced SQSTM1 levels and improved CFTR function from nasal epithelial cells in vivo, correlating with a decrease of chloride concentrations in sweat, as well as with a reduction of the abundance of TNF/TNF-alpha (tumor necrosis factor) and CXCL8 (chemokine [C-X-C motif] ligand 8) transcripts in nasal brushing and TNF and CXCL8 protein levels in the sputum. Altogether, these results suggest that optimal schedules of cysteamine plus EGCG might be used for the treatment of CF caused by the F508del-CFTR mutation.

  2. Rescue of Murine F508del CFTR Activity in Native Intestine by Low Temperature and Proteasome Inhibitors

    PubMed Central

    Wilke, Martina; Bot, Alice; Jorna, Huub; Scholte, Bob J.; de Jonge, Hugo R.

    2012-01-01

    Most patients with Cystic Fibrosis (CF) carry at least one allele with the F508del mutation, resulting in a CFTR chloride channel protein with a processing, gating and stability defect, but with substantial residual activity when correctly sorted to the apical membranes of epithelial cells. New therapies are therefore aimed at improving the folding and trafficking of F508del CFTR, (CFTR correctors) or at enhancing the open probability of the CFTR chloride channel (CFTR potentiators). Preventing premature breakdown of F508del CFTR is an alternative or additional strategy, which is investigated in this study. We established an ex vivo assay for murine F508del CFTR rescue in native intestinal epithelium that can be used as a pre-clinical test for candidate therapeutics. Overnight incubation of muscle stripped ileum in modified William's E medium at low temperature (26°C), and 4 h or 6 h incubation at 37°C with different proteasome inhibitors (PI: ALLN, MG-132, epoxomicin, PS341/bortezomib) resulted in fifty to hundred percent respectively of the wild type CFTR mediated chloride secretion (forskolin induced short-circuit current). The functional rescue was accompanied by enhanced expression of the murine F508del CFTR protein at the apical surface of intestinal crypts and a gain in the amount of complex-glycosylated CFTR (band C) up to 20% of WT levels. Sustained rescue in the presence of brefeldin A shows the involvement of a post-Golgi compartment in murine F508del CFTR degradation, as was shown earlier for its human counterpart. Our data show that proteasome inhibitors are promising candidate compounds for improving rescue of human F508del CFTR function, in combination with available correctors and potentiators. PMID:23284872

  3. Análisis del espectro infrarrojo del polvo interestelar asociado con cúmulos globulares y de su evolución temporal

    NASA Astrophysics Data System (ADS)

    Pellizza, L. J.; Forte, J. C.; Carpintero, D.

    El trabajo que se presenta investiga la dinámica de las partículas de polvo interestelar eyectadas por estrellas gigantes rojas en un cúmulo globular utilizando simulaciones numéricas de su interacción con el campo gravitatorio y con la radiación electromagnética de las estrellas. Se pretende con ello determinar la distribución espacial de ese material como una función del tiempo en un sistema similar a NGC 104 (47 Tuc). A partir de la distribución espacial resultante se obtuvo el espectro infrarrojo integrado el cual sugiere que el máximo contraste con la radiación estelar ocurre en longitudes de onda cercanas a 300 μm y que decrece rápidamente hacia longitudes de onda menores, en las que suelen realizarse las observaciones.

  4. 500 days of Stromgren b, y and narrow-band [OIII], H α photometric evolution of gamma-ray Nova Del 2013 (=V339 Del)

    NASA Astrophysics Data System (ADS)

    Munari, Ulisse; Maitan, Alessandro; Moretti, Stefano; Tomaselli, Salvatore

    2015-10-01

    We present and discuss highly accurate photometry obtained through medium Stromgren y, b bands and narrow [OIII], Hα bands covering 500 days of the evolution of Nova Del 2013 since its maximum brightness. This is by far the most complete study of any nova observed in such photometric systems. The nova behavior in these photometric bands is very different from that observed with the more conventional broad bands like UBVRC IC or u‧g‧r‧i‧z‧ , providing unique information about extent and ionization of the ejecta, the onset of critical phases like the transition between optically thick and thin conditions, and re-ionization by the central super-soft X-ray source. The actual transmission profiles of the y, b , [OIII] and Hα photometric filters have been accurately measured at different epochs and different illumination angles, to evaluate in detail their performance under exact operating conditions. The extreme smoothness of both the Hα and [OIII] lightcurves argues for absence of large and abrupt discontinuities in the ejecta of Nova Del 2013. Should they exist, glitches in the lightcurves would have appeared when the ionization and/or recombination fronts overtook them. During the period of recorded very large variability (up to 100× over a single day) in the super-soft X-ray emission (from day +69 to +86 past V maximum), no glitch in excess of 1% was observed in the optical photometry, either in the continuum (Stromgren y) or in the lines ([OIII] and Hα filters), or in a combination of the two (Stromgren b, Johnson B and V). Considering that the recombination time scale in the ejecta was one week at that time, this excludes global changes of the white dwarf as the source of the X-ray variability and supports instead clumpy ejecta passing through the line of sight to us as its origin.

  5. The Torres del Paine intrusion as a model for a shallow magma chamber

    NASA Astrophysics Data System (ADS)

    Baumgartner, Lukas; Bodner, Robert; Leuthold, Julien; Muntener, Othmar; Putlitz, Benita; Vennemann, Torsten

    2014-05-01

    The shallow magmatic Torres del Paine Intrusive Complex (TPIC) belongs to a series of sub-volcanic and plutonic igneous bodies in Southern Chile and Argentina. This trench-parallel belt is located in a transitional position between the Patagonia Batholith in the West, and the alkaline Cenozoic plateau lavas in the East. While volumetrically small amounts of magmatism started around 28 my ago in the Torres del Paine area, and a second period occurred between 17-16 Ma, it peaked with the TPIC 12.59-12.43 Ma ago. The spectacular cliffs of the Torres del Paine National park provide a unique opportunity to study the evolution of a very shallow magma chamber and the interaction with its host rocks. Intrusion depth can be estimated based on contact metamorphic assemblages and granite solidus thermobarometry to 750±250 bars, corresponding to an intrusion depth of ca. 3km, ca. 500m above the base of the intrusion. Hornblende thermobarometry in mafic rocks agrees well with these estimates (Leuthold et al., 2014). The TPIC is composed of a granitic laccolith emplaced over 90ka (Michel et al., 2008) in 3 major, several 100m thick sheets, forming an overall thickness of nearly 2 km. Contacts are sharp between sheets, with the oldest sheet on the top and the youngest on the bottom (Michel et al., 2008). The granitic laccolith is under-plated by a ca. 400m thick mafic laccolith, built up over ca. 50ka (Leuthold et al. 2012), constructed from the bottom up. Granitic and mafic sheets are themselves composed of multiple metric to decametric pulses, mostly with ductile contacts between them, resulting in outcrop patterns resembling braided stream sediments. The contact of the TPIC with the Cretaceous flysch sediments document intrusion mechanism. Pre-existing sub-horizontal fold axes are rotated in the roof of the TPIC, clearly demonstrating ballooning of the roof; no ballooning was observed in the footwall of the intrusion. Extension during ballooning of the roof is indicated by

  6. Genetic Inhibition Of The Ubiquitin Ligase Rnf5 Attenuates Phenotypes Associated To F508del Cystic Fibrosis Mutation

    PubMed Central

    Tomati, Valeria; Sondo, Elvira; Armirotti, Andrea; Caci, Emanuela; Pesce, Emanuela; Marini, Monica; Gianotti, Ambra; Ju Jeon, Young; Cilli, Michele; Pistorio, Angela; Mastracci, Luca; Ravazzolo, Roberto; Scholte, Bob; Ronai, Ze’ev; Galietta, Luis J. V.; Pedemonte, Nicoletta

    2015-01-01

    Cystic fibrosis (CF) is caused by mutations in the CFTR chloride channel. Deletion of phenylalanine 508 (F508del), the most frequent CF mutation, impairs CFTR trafficking and gating. F508del-CFTR mistrafficking may be corrected by acting directly on mutant CFTR itself or by modulating expression/activity of CFTR-interacting proteins, that may thus represent potential drug targets. To evaluate possible candidates for F508del-CFTR rescue, we screened a siRNA library targeting known CFTR interactors. Our analysis identified RNF5 as a protein whose inhibition promoted significant F508del-CFTR rescue and displayed an additive effect with the investigational drug VX-809. Significantly, RNF5 loss in F508del-CFTR transgenic animals ameliorated intestinal malabsorption and concomitantly led to an increase in CFTR activity in intestinal epithelial cells. In addition, we found that RNF5 is differentially expressed in human bronchial epithelia from CF vs. control patients. Our results identify RNF5 as a target for therapeutic modalities to antagonize mutant CFTR proteins. PMID:26183966

  7. Developing market class specific InDel markers from next generation sequence data in Phaseolus vulgaris L.

    PubMed

    Moghaddam, Samira Mafi; Song, Qijian; Mamidi, Sujan; Schmutz, Jeremy; Lee, Rian; Cregan, Perry; Osorno, Juan M; McClean, Phillip E

    2014-01-01

    Next generation sequence data provides valuable information and tools for genetic and genomic research and offers new insights useful for marker development. This data is useful for the design of accurate and user-friendly molecular tools. Common bean (Phaseolus vulgaris L.) is a diverse crop in which separate domestication events happened in each gene pool followed by race and market class diversification that has resulted in different morphological characteristics in each commercial market class. This has led to essentially independent breeding programs within each market class which in turn has resulted in limited within market class sequence variation. Sequence data from selected genotypes of five bean market classes (pinto, black, navy, and light and dark red kidney) were used to develop InDel-based markers specific to each market class. Design of the InDel markers was conducted through a combination of assembly, alignment and primer design software using 1.6× to 5.1× coverage of Illumina GAII sequence data for each of the selected genotypes. The procedure we developed for primer design is fast, accurate, less error prone, and higher throughput than when they are designed manually. All InDel markers are easy to run and score with no need for PCR optimization. A total of 2687 InDel markers distributed across the genome were developed. To highlight their usefulness, they were employed to construct a phylogenetic tree and a genetic map, showing that InDel markers are reliable, simple, and accurate.

  8. Developing market class specific InDel markers from next generation sequence data in Phaseolus vulgaris L.

    PubMed Central

    Moghaddam, Samira Mafi; Song, Qijian; Mamidi, Sujan; Schmutz, Jeremy; Lee, Rian; Cregan, Perry; Osorno, Juan M.; McClean, Phillip E.

    2013-01-01

    Next generation sequence data provides valuable information and tools for genetic and genomic research and offers new insights useful for marker development. This data is useful for the design of accurate and user-friendly molecular tools. Common bean (Phaseolus vulgaris L.) is a diverse crop in which separate domestication events happened in each gene pool followed by race and market class diversification that has resulted in different morphological characteristics in each commercial market class. This has led to essentially independent breeding programs within each market class which in turn has resulted in limited within market class sequence variation. Sequence data from selected genotypes of five bean market classes (pinto, black, navy, and light and dark red kidney) were used to develop InDel-based markers specific to each market class. Design of the InDel markers was conducted through a combination of assembly, alignment and primer design software using 1.6× to 5.1× coverage of Illumina GAII sequence data for each of the selected genotypes. The procedure we developed for primer design is fast, accurate, less error prone, and higher throughput than when they are designed manually. All InDel markers are easy to run and score with no need for PCR optimization. A total of 2687 InDel markers distributed across the genome were developed. To highlight their usefulness, they were employed to construct a phylogenetic tree and a genetic map, showing that InDel markers are reliable, simple, and accurate. PMID:24860578

  9. miR-16 rescues F508del-CFTR function in native cystic fibrosis epithelial cells.

    PubMed

    Kumar, P; Bhattacharyya, S; Peters, K W; Glover, M L; Sen, A; Cox, R T; Kundu, S; Caohuy, H; Frizzell, R A; Pollard, H B; Biswas, R

    2015-11-01

    Cystic fibrosis (CF) is due to mutations in the CFTR gene, which prevents correct folding, trafficking and function of the mutant cystic fibrosis transmembrane conductance regulator (CFTR) protein. The dysfunctional effect of CFTR mutations, principally the F508del-CFTR mutant, is further manifested by hypersecretion of the pro-inflammatory chemokine interleukin-8 into the airway lumen, which further contributes to morbidity and mortality. We have hypothesized that microRNA (miR)-based therapeutics could rescue the dysfunctional consequences of mutant CFTR. Here we report that a miR-16 mimic can effectively rescue F508del-CFTR protein function in airway cell lines and primary cultures, of differentiated human bronchial epithelia from F508del homozygotes, which express mutant CFTR endogenously. We also identify two other miRs, miR-1 and miR-302a, which are also active. Although miR-16 is expressed at basal comparable levels in CF and control cells, miR-1 and miR-302a are undetectable. When miR mimics are expressed in CF lung or pancreatic cells, the expression of the F508del-CFTR protein is significantly increased. Importantly, miR-16 promotes functional rescue of the cyclic AMP-activated apical F508del-CFTR chloride channel in primary lung epithelial cells from CF patients. We interpret these findings to suggest that these miRs may constitute novel targets for CF therapy.

  10. Hypothesizing an ancient Greek origin of the GJB2 35delG mutation: can science meet history?

    PubMed

    Kokotas, Haris; Grigoriadou, Maria; Villamar, Manuela; Giannoulia-Karantana, Aglaia; del Castillo, Ignacio; Petersen, Michael B

    2010-04-01

    One specific mutation of the GJB2 gene that encodes the connexin 26 protein, the 35delG mutation, has become a major interest among scientists who focus on the genetics of nonsyndromic hearing loss. The mutation accounts for the majority of GJB2 mutations detected in Caucasian populations and represents one of the most frequent disease mutations identified so far. The debate was so far between the arguments whether or not the 35delG mutation constitutes a mutational hot-spot or a founder effect; however, it was recently clarified that the latter seems the most likely. In an attempt to explore the origin and propagation of the 35delG mutation, several groups have reported the prevalence of the mutation and the carrier rates in different populations worldwide. It is now certain that the theory of a common founder prevails and that the highest carrier frequencies of the 35delG mutation are observed in southern European populations, giving rise to a discussion regarding the origin of the 35delG mutation. In this study, we discuss data previously published by our and other groups and also compare the haplotype distribution of the mutation in southern Europe, trying to understand the pathways of science and history and the conflict between them.

  11. Developing market class specific InDel markers from next generation sequence data in Phaseolus vulgaris L.

    PubMed

    Moghaddam, Samira Mafi; Song, Qijian; Mamidi, Sujan; Schmutz, Jeremy; Lee, Rian; Cregan, Perry; Osorno, Juan M; McClean, Phillip E

    2014-01-01

    Next generation sequence data provides valuable information and tools for genetic and genomic research and offers new insights useful for marker development. This data is useful for the design of accurate and user-friendly molecular tools. Common bean (Phaseolus vulgaris L.) is a diverse crop in which separate domestication events happened in each gene pool followed by race and market class diversification that has resulted in different morphological characteristics in each commercial market class. This has led to essentially independent breeding programs within each market class which in turn has resulted in limited within market class sequence variation. Sequence data from selected genotypes of five bean market classes (pinto, black, navy, and light and dark red kidney) were used to develop InDel-based markers specific to each market class. Design of the InDel markers was conducted through a combination of assembly, alignment and primer design software using 1.6× to 5.1× coverage of Illumina GAII sequence data for each of the selected genotypes. The procedure we developed for primer design is fast, accurate, less error prone, and higher throughput than when they are designed manually. All InDel markers are easy to run and score with no need for PCR optimization. A total of 2687 InDel markers distributed across the genome were developed. To highlight their usefulness, they were employed to construct a phylogenetic tree and a genetic map, showing that InDel markers are reliable, simple, and accurate. PMID:24860578

  12. Towards a systematic construction of realistic D-brane models on a del Pezzo singularity

    NASA Astrophysics Data System (ADS)

    Dolan, Matthew J.; Krippendorf, Sven; Quevedo, Fernando

    2011-10-01

    A systematic approach is followed in order to identify realistic D-brane models at toric del Pezzo singularities. Requiring quark and lepton spectrum and Yukawas from D3 branes and massless hypercharge, we are led to Pati-Salam extensions of the Standard Model. Hierarchies of masses, flavour mixings and control of couplings select higher order del Pezzo singularities, minimising the Higgs sector prefers toric del Pezzos with dP 3 providing the most successful compromise. Then a supersymmetric local string model is presented with the following properties at low energies: (i) the MSSM spectrum plus a local B - L gauge field or additional Higgs fields depending on the breaking pattern, (ii) a realistic hierarchy of quark and lepton masses and (iii) realistic flavour mixing between quark and lepton families with computable CKM and PMNS matrices, and CP violation consistent with observations. In this construction, kinetic terms are diagonal and under calculational control suppressing standard FCNC contributions. Proton decay operators of dimension 4, 5, 6 are suppressed, and gauge couplings can unify depending on the breaking scales from string scales at energies in the range 1012-1016 GeV, consistent with TeV soft-masses from moduli mediated supersymmetry breaking. The GUT scale model corresponds to D3 branes at dP 3 with two copies of the Pati-Salam gauge symmetry SU(4) × SU(2) R × SU(2) L . D-brane instantons generate a non-vanishing μ-term. Right handed sneutrinos can break the B - L symmetry and induce a see-saw mechanism of neutrino masses and R-parity violating operators with observable low-energy implications.

  13. F508del-CFTR rescue: a matter of cell stress response.

    PubMed

    Nieddu, Erika; Pollarolo, Benedetta; Merello, Luisa; Schenone, Silvia; Mazzei, Mauro

    2013-01-01

    Cystic fibrosis (CF) is a common inherited fatal disease affecting 70,000 people worldwide, with a median predicted age of survival of approximately 38 years. The deletion of Phenylalanine in position 508 of the Cystic Fibrosis Transmembrane conductance Regulator (F508del-CFTR) is the most common mutation in CF patients: the deleted protein, not properly folded, is degraded. To date no commercial drugs are available. Low temperature, some osmolytes and conditions able to induce heat shock protein 70 (Hsp70) expression and heat shock cognate 70 (Hsc70) inhibition result in F508del-CFTR rescue, hence restoring its physiological function: this review sheds light on the correlation between these several evidences. Interestingly, all these approaches have a role in the cell stress response (CSR), a set of cell reactions to stress. In addition, unpredictably, F508del-CFTR rescue has to be considered in the frame of CSR: entities that induce - or are induced during - the CSR are, in general, also able to correct trafficking defect of CFTR. Specifically, the low temperature induces, by definition, a CSR; osmolytes, such as glycerol and trimethylamine N-oxide (TMAO), are products of the CSR; pharmacological correctors, such as Matrine and 4-phenylbutirric acid (4PBA), down-regulate the constitutive Hsc70 in favor of an up-regulation of the inducible chaperone Hsp70, another component of the CSR. The identification of a common mechanism of action for different types of correctors could drive the discovery of new active molecules in CF, overcoming methods clinically inapplicable, such as the low temperature. PMID:23331026

  14. Biophysical characterisation of calumenin as a charged F508del-CFTR folding modulator.

    PubMed

    Tripathi, Rashmi; Benz, Nathalie; Culleton, Bridget; Trouvé, Pascal; Férec, Claude

    2014-01-01

    The cystic fibrosis transmembrane regulator (CFTR) is a cyclic-AMP dependent chloride channel expressed at the apical surface of epithelial cells lining various organs such as the respiratory tract. Defective processing and functioning of this protein caused by mutations in the CFTR gene results in loss of ionic balance, defective mucus clearance, increased proliferation of biofilms and inflammation of human airways observed in cystic fibrosis (CF) patients. The process by which CFTR folds and matures under the influence of various chaperones in the secretory pathway remains incompletely understood. Recently, calumenin, a secretory protein, belonging to the CREC family of low affinity calcium binding proteins has been identified as a putative CFTR chaperone whose biophysical properties and functions remain uncharacterized. We compared hydropathy, instability, charge, unfoldability, disorder and aggregation propensity of calumenin and other CREC family members with CFTR associated chaperones and calcium binding proteins, wild-type and mutant CFTR proteins and intrinsically disordered proteins (IDPs). We observed that calumenin, along with other CREC proteins, was significantly more charged and less folded compared to CFTR associated chaperones. Moreover like IDPs, calumenin and other CREC proteins were found to be less hydrophobic and aggregation prone. Phylogenetic analysis revealed a close link between calumenin and other CREC proteins indicating how evolution might have shaped their similar biophysical properties. Experimentally, calumenin was observed to significantly reduce F508del-CFTR aggregation in a manner similar to AavLEA1, a well-characterized IDP. Fluorescence microscopy based imaging analysis also revealed altered trafficking of calumenin in bronchial cells expressing F508del-CFTR, indicating its direct role in the pathophysiology of CF. In conclusion, calumenin is characterized as a charged protein exhibiting close similarity with IDPs and is

  15. Oxygen isotope evidence for submarine hydrothermal alteration of the Del Puerto ophiolite, California

    USGS Publications Warehouse

    Schiffman, P.; Williams, A.E.; Evarts, R.C.

    1984-01-01

    The oxygen isotope compositions and metamorphic mineral assemblages of hydrothermally altered rocks from the Del Puerto ophiolite and overlying volcaniclastic sedimentary rocks at the base of the Great Valley sequence indicate that their alteration occurred in a submarine hydrothermal system. Whole rock ??18O compositions decrease progressively down section (with increasing metamorphic grade): +22.4??? (SMOW) to +13.8 for zeolite-bearing volcaniclastic sedimentary rocks overlying the ophiolite; +19.6 to +11.6 for pumpellyite-bearing metavolcanic rocks in the upper part of the ophiolite's volcanic member; +12.3 to +8.1 for epidote-bearing metavolcanic rocks in the lower part of the volcanic member; +8.5 to +5.7 for greenschist facies rocks from the ophiolite's plutonic member; +7.6 to +5.8 for amphibolite facies or unmetamorphosed rocks from the plutonic member. Modelling of fluid-rock interaction in the Del Puerto ophiolite indicates that the observed pattern of upward enrichment in whole rock ??18O can be best explained by isotopic exchange with discharging 18O-shifted seawater at fluid/rock mass ratios near 2 and temperatures below 500??C. 18O-depleted plutonic rocks necessarily produced during hydrothermal circulation were later removed as a result of tectonism. Submarine weathering and later burial metamorphism at the base of the Great Valley sequence cannot by itself have produced the zonation of hydrothermal minerals and the corresponding variations in oxygen isotope compositions. The pervasive zeolite and prehnite-pumpellyite facies mineral assemblages found in the Del Puerto ophiolite may reflect its origin near an island arc rather than deep ocean spreading center. ?? 1984.

  16. Biophysical characterisation of calumenin as a charged F508del-CFTR folding modulator.

    PubMed

    Tripathi, Rashmi; Benz, Nathalie; Culleton, Bridget; Trouvé, Pascal; Férec, Claude

    2014-01-01

    The cystic fibrosis transmembrane regulator (CFTR) is a cyclic-AMP dependent chloride channel expressed at the apical surface of epithelial cells lining various organs such as the respiratory tract. Defective processing and functioning of this protein caused by mutations in the CFTR gene results in loss of ionic balance, defective mucus clearance, increased proliferation of biofilms and inflammation of human airways observed in cystic fibrosis (CF) patients. The process by which CFTR folds and matures under the influence of various chaperones in the secretory pathway remains incompletely understood. Recently, calumenin, a secretory protein, belonging to the CREC family of low affinity calcium binding proteins has been identified as a putative CFTR chaperone whose biophysical properties and functions remain uncharacterized. We compared hydropathy, instability, charge, unfoldability, disorder and aggregation propensity of calumenin and other CREC family members with CFTR associated chaperones and calcium binding proteins, wild-type and mutant CFTR proteins and intrinsically disordered proteins (IDPs). We observed that calumenin, along with other CREC proteins, was significantly more charged and less folded compared to CFTR associated chaperones. Moreover like IDPs, calumenin and other CREC proteins were found to be less hydrophobic and aggregation prone. Phylogenetic analysis revealed a close link between calumenin and other CREC proteins indicating how evolution might have shaped their similar biophysical properties. Experimentally, calumenin was observed to significantly reduce F508del-CFTR aggregation in a manner similar to AavLEA1, a well-characterized IDP. Fluorescence microscopy based imaging analysis also revealed altered trafficking of calumenin in bronchial cells expressing F508del-CFTR, indicating its direct role in the pathophysiology of CF. In conclusion, calumenin is characterized as a charged protein exhibiting close similarity with IDPs and is

  17. F508del-CFTR rescue: a matter of cell stress response.

    PubMed

    Nieddu, Erika; Pollarolo, Benedetta; Merello, Luisa; Schenone, Silvia; Mazzei, Mauro

    2013-01-01

    Cystic fibrosis (CF) is a common inherited fatal disease affecting 70,000 people worldwide, with a median predicted age of survival of approximately 38 years. The deletion of Phenylalanine in position 508 of the Cystic Fibrosis Transmembrane conductance Regulator (F508del-CFTR) is the most common mutation in CF patients: the deleted protein, not properly folded, is degraded. To date no commercial drugs are available. Low temperature, some osmolytes and conditions able to induce heat shock protein 70 (Hsp70) expression and heat shock cognate 70 (Hsc70) inhibition result in F508del-CFTR rescue, hence restoring its physiological function: this review sheds light on the correlation between these several evidences. Interestingly, all these approaches have a role in the cell stress response (CSR), a set of cell reactions to stress. In addition, unpredictably, F508del-CFTR rescue has to be considered in the frame of CSR: entities that induce - or are induced during - the CSR are, in general, also able to correct trafficking defect of CFTR. Specifically, the low temperature induces, by definition, a CSR; osmolytes, such as glycerol and trimethylamine N-oxide (TMAO), are products of the CSR; pharmacological correctors, such as Matrine and 4-phenylbutirric acid (4PBA), down-regulate the constitutive Hsc70 in favor of an up-regulation of the inducible chaperone Hsp70, another component of the CSR. The identification of a common mechanism of action for different types of correctors could drive the discovery of new active molecules in CF, overcoming methods clinically inapplicable, such as the low temperature.

  18. Petroleum geology of the deltaic sequence, Rio Del Rey basin, offshore Cameroon

    SciTech Connect

    Coughlin, R.M.; Bement, W.O.; Maloney, W.V. )

    1993-09-01

    The Rio Del Rey Basin of offshore Cameroon comprises the easternmost portion of the Niger delta complex. In the delta flank setting, the overall package is thinner and stratigraphic correlation simpler than in the depocenter to the west so the distribution of reservoirs and seals is well defined. Productive reservoirs are shallow, typically less than 2000 m, and mostly hydropressured to slightly overpressured. Reservoir properties generally are excellent and seismic bright-spot technology has played a major role in exploration and development efforts. Rio Del Rey is characterized by three main structural styles from north to south: (1) detachment-based growth faults, (2) highly faulted, mobile shale cored domes and ridges, and (3) toe thrusts and folds. Virtually all individual traps are fault dependent and lack of sufficient internal seals in sand-rich wave-dominated deltaic sequences can limit the objective window. Most fields are downthrown fault traps in which hanging-wall reservoirs are effectively sealed against older prodelta and marine shales. All large oil fields are located in the dome and ridge province and are potential analogs for similar structures now being explored on the upper slope off Nigeria. The best quality source rocks identified thus far are Paleocene to Eocene marine shales. Oil vs. gas distribution in the basin is a function of variations in the kerogen type, organic richness, and maturity of these source rocks. A significant quantity of the gas found to date in Rio Del Rey is biogenic in origin. The Cameroon charge model may aid in better understanding hydrocarbon distribution on offshore Nigeria, where the Miocene deltaic section is much thicker and potential Paleocene-Eocene source rocks likely are unpenetrated. The shallow deltaic play in Cameroon is relatively mature. Future exploration likely will focus on identifying deeper, nonbright-spot-supported opportunities including potential stratigraphic traps.

  19. Multimodal Assessment of Protein Functional Deficiency Supports Pathogenicity of BRCA1 p.V1688del

    PubMed Central

    De Nicolo, Arcangela; Parisini, Emilio; Zhong, Quan; Palma, Maurizia Dalla; Stoeckert, Kathryn A.; Domchek, Susan M.; Nathanson, Katherine L.; Caligo, Maria A.; Vidal, Marc; Cusick, Michael E.; Garber, Judy E.

    2009-01-01

    Unequivocal discrimination between neutral variants and deleterious mutations is crucial for appropriate counseling of individuals with a BRCA1 or BRCA2 sequence change. An increasing number of variants of uncertain significance (VUSs) are being identified, whose unclassified biological effect poses clinical concerns. A multifactorial likelihood-based approach recently suggested disease causality for BRCA1 p.V1688del, a VUS recurrent in Italian breast/ovarian cancer families. Whether and how this single amino acid deletion in the BRCA1 BRCT domain affects the function of the mutant protein (ΔValBRCA1) has not been elucidated. We undertook comprehensive functional characterization of ΔValBRCA1, comprising comparative structural modeling, analysis of protein stability and associations, and analysis of DNA repair function. Our model predicted BRCT domain destabilization and folding disruption caused by BRCA1 p.V1688del. Consistently, the recombinant ΔValBRCA1 was less stable than wtBRCA1 and, unlike the latter, failed to associate with BRIP1, CtIP, and Rap80, and to re-localize to sites of DNA damage. Yeast two-hybrid analysis revealed a compromised interaction with FHL2 and with KPNA2, which is likely responsible for improper subcellular localization of ΔValBRCA1. In addition, we found four new breast/ovarian cancer families of Italian ancestry who carried this sequence alteration. These results provide the first evidence of the effect of BRCA1 p.V1688del on protein stability and function, supporting the view that it is a deleterious mutation. Multimodal analyses like ours could advance understanding of tumor suppression by BRCA1, and ultimately contribute to developing efficient strategies for screening and characterization of VUSs. PMID:19706752

  20. Early neogene history of the central American arc from Bocas del Toro, western Panama

    USGS Publications Warehouse

    Coates, A.G.; Aubry, M.-P.; Berggren, W.A.; Collins, Luke S.; Kunk, M.

    2003-01-01

    A newly discovered sequence of lower to middle Miocene rocks from the eastern Bocas del Toro archipelago, western Panama, reveals the timing and environment of the earliest stages in the rise of the Isthmus of Panama in this region. Two new formations, the Punta Alegre Formation (lower Miocene, Aquitanian to Burdigalian) and the Valiente Formation (middle Miocene, Langhian to Serravallian), are here named and formally described. The Punta Alegre Formation contains a diagnostic microfauna of benthic and planktic foraminifera and calcareous nannofossils that indicate deposition in a 2000-m-deep pre-isthmian neotropical ocean from as old as 21.5-18.3 Ma. Its lithology varies from silty mudstone to muddy foraminiferal ooze with rare thin microturbidite layers near the top. The Valiente Formation, which ranges in age from 16.4 to ca. 12.0 Ma, lies with slight angular unconformity on the Punta Alegre Formation and consists of five lithofacies: (1) columnar basalt and flow breccia, (2) pyroclastic deposits, (3) coarse-grained volcaniclastic deposits, (4) coral-reef limestone with diverse large coral colonies, and (5) marine debris-flow deposits and microturbidities. These lithofacies are interpreted to indicate that after ca. 16 Ma a volcanic arc developed in the region of Bocas del Toro and that by ca. 12 Ma an extensively emergent archipelago of volcanic islands had formed. 39Ar/40Ar dating of basalt flows associated with the fossiliferous sedimentary rocks in the upper part of the Valiente Formation strongly confirms the ages derived from planktic foraminifera and nannofossils. Paleobathymetric analysis of the two new formations in the Valiente Peninsula and Popa Island, in the Bocas del Toro archipelago, shows a general shallowing from lower- through upper-bathyal to upper-neritic and emergent laharic and fluviatile deposits from ca. 19 to 12 Ma. The overlying nonconformable Bocas del Toro Group contains a lower transgressive sequence ranging from basal nearshore

  1. Stratigraphic context and direct dating of the Neandertal mandible from Cova del Gegant (Sitges, Barcelona).

    PubMed

    Daura, J; Sanz, M; Pike, A W G; Subirà, M E; Fornós, J J; Fullola, J M; Julià, R; Zilhão, J

    2010-07-01

    Stratigraphic study of the Cova del Gegant's sedimentary fill revealed different cycles of accumulation of typical interior cave and delta facies. A precise chronology for these deposits, the faunal remains and stone tools contained therein was obtained by radiocarbon, U-Th and OSL. Our results indicate that the Upper Pleistocene archaeological sequence dates between 49.3 +/- 1.8 ka BP, the U-Th age of the overlying flowstone, and 60.0 +/- 3.9 ka BP, the OSL age of the basal deposits. We have also directly dated the site's Neandertal mandible to 52.3 +/- 2.3 ka by U-Th.

  2. Uranium series dating of human skeletal remains from the del mar and sunnyvale sites, california.

    PubMed

    Bischoff, J L; Rosenbauer, R J

    1981-08-28

    Uranium series analyses of human bone samples from the Del Mar and Sunnyvale sites indicate ages of 11,000 and 8,300 years, respectively. The dates are supported by internal concordancy between thorium-230 and protactinium-231 decay systems. These ages are significantly younger than the estimates of 48,000 and 70,000 years based on amino acid racemization, and indicate that the individuals could derive from the population waves that came across the Bering Strait during the last sea-level low.

  3. Uranium series dating of human skeletal remains from the del mar and sunnyvale sites, california.

    PubMed

    Bischoff, J L; Rosenbauer, R J

    1981-08-28

    Uranium series analyses of human bone samples from the Del Mar and Sunnyvale sites indicate ages of 11,000 and 8,300 years, respectively. The dates are supported by internal concordancy between thorium-230 and protactinium-231 decay systems. These ages are significantly younger than the estimates of 48,000 and 70,000 years based on amino acid racemization, and indicate that the individuals could derive from the population waves that came across the Bering Strait during the last sea-level low. PMID:17789030

  4. Mortality according to age and burned body surface in the Virgen del Rocio University Hospital.

    PubMed

    Gómez-Cía, T; Mallén, J; Márquez, T; Portela, C; Lopez, I

    1999-06-01

    The application of updated clinical protocols for the treatment of burned patients is showing very good results. The mortality curves according to age and the percentage of burned body surface could be of great use for the comparison of clinical results between different burns units. The probability of survival in 1000 consecutive patients admitted to the Burns Unit of the Virgen del Rocio University Hospital between July, 1993 and August, 1997, is compared, by graphic analysis, with the mortality curves of other centers, obtaining similar results. We conclude that the results of medical attendance in our unit are in line with those considered as a reference.

  5. Eruption of the nevado del ruiz volcano, Colombia, on 13 november 1985: tephra fall and lahars.

    PubMed

    Naranjo, J L; Sigurdsson, H; Carey, S N; Fritz, W

    1986-08-29

    A small Plinian eruption of the Nevado del Ruiz volcano in Colombia ejected 3.5 x 10(10) kilograms of mixed dacite and andesite tephra on 13 November 1985, with a maximum column height of 31 kilometers above sea level. Small pyroclastic flows and surges, generated during the initial stage of the eruption, caused surface melting of approximately 10% of the volcano's ice cap, leading to meltwater floods. The erosive floods incorporated soils and loose sediments from the volcano's flanks and developed into lahars, which claimed at least 25,000 lives.

  6. Descripción del coronógrafo a ser instalado en Argentina (MICA)

    NASA Astrophysics Data System (ADS)

    Stenborg, G.; Francile, C.; Schwenn, R.; Epple, A.; Rovira, M.

    El ``Coronógrafo de espejo para Argentina'' es un telescopio solar terrestre a ser colocado en el Observatorio Astronómico Félix Aguilar (El Leoncito), antes de finalizar 1996, como parte de un programa de ciencia bilateral entre Alemania y Argentina. Eclipses fotográficos de alta resolución han revelado que la corona solar es altamente estructurada y variable. De hecho, está contínuamente deformada y moldeada por los movimientos convectivos de los extremos de los arcos magnéticos en la fotosfera, estando, en muchas oportunidades, afectada por explosivas liberaciones de energía. MICA, en conjunción con otros telescopios solares espaciales y terrestres, tratará de contribuir al entendimiento de cuestiones fundamentales de la física solar. Entre ellas: cómo la corona está siendo calentada, dónde y cómo el viento solar es acelerado, qué causa los transitorios coronales, etc. Para ello investigará la distribución de los parámetros del plasma y su evolución con el tiempo, la estructura espacial de la corona en fina y gran escala, procesos que ocurren en los transitorios coronales y factores que los disparan, etc. Para responder a estas cuestiones MICA observará la atmósfera solar por sobre el limbo entre 1.1 y 2 radios solares aproximadamente, usando un nuevo tipo de sistema coronográfico que permite suprimir el brillo del disco solar suficientemente bien, tomando las imágenes con una cámara CCD de 1024x1024 pixels, codificada en 12 bits, pudiendo el mismo ser operado en forma remota. En la presente exposición describiremos las características del instrumento, cómo será controlado y qué esperamos observar basados en las imágenes obtenidas por los telescopios de similares características LASCO C1 a bordo del SOHO y PICO (ubicado en el Observatorio de Pic du Midi, Francia).

  7. Eruption of the nevado del ruiz volcano, Colombia, on 13 november 1985: tephra fall and lahars.

    PubMed

    Naranjo, J L; Sigurdsson, H; Carey, S N; Fritz, W

    1986-08-29

    A small Plinian eruption of the Nevado del Ruiz volcano in Colombia ejected 3.5 x 10(10) kilograms of mixed dacite and andesite tephra on 13 November 1985, with a maximum column height of 31 kilometers above sea level. Small pyroclastic flows and surges, generated during the initial stage of the eruption, caused surface melting of approximately 10% of the volcano's ice cap, leading to meltwater floods. The erosive floods incorporated soils and loose sediments from the volcano's flanks and developed into lahars, which claimed at least 25,000 lives. PMID:17732038

  8. Holocene paleoclimate characterization in Lago Fagnano (Tierra del Fuego) using sedimentary, physical and geochemical proxies

    NASA Astrophysics Data System (ADS)

    Vizcaino Marti, A.; Dunbar, R. B.; Wahl, D.; Moy, C. M.; Mucciarone, D. A.; Anderson, L.; Guilderson, T. P.

    2010-12-01

    Tierra del Fuego is the world's southernmost landmass outside of Antarctica. Two features of ocean circulation control the climate of Tierra del Fuego: the Southern Ocean circumpolar flow and the South Pacific Gyre. Together with Patagonia, Tierra del Fuego is the only terrestrial region directly influenced by the southern hemisphere westerly winds. This region is also a tectonically active area affected by volcanic and seismic activity related to South American and Scotia-Antarctic plate boundaries. Accommodated along the Magallanes-Fagnano fault system, as part of the plate boundary, the Lago Fagnano is the largest lake in Tierra del Fuego. This E-W trending lake is 100 km long and 5-15 km wide. Our investigations were carried out on the upper 4 meters of an 8.4 m long piston core obtained at 69 m water depth in Bahía Grande (LF06-PC8); a southwestern lake sub-basin separated from the main lake by a shallow sill. Our studies are based on the integration of sediment description, physical properties, pollen, and geochemical analyses including C and N isotopes (1cm interval) and XRF scan (1mm interval). The age model for the core is based on radiocarbon ages and tephrochronology. Additionally, a 800 km long grid of high resolution seismic profiles support the sedimentary analyses and allow the correlation with other cores from within the lake basin. LF06-PC8 yields continuous and high accumulation-rate sedimentary sections for Lago Fagnano. The presented sediment record corresponds to a laminated hemipelagite with presence of a single but complex mass transport deposit interval. An accurate sedimentological interpretation of the core together with the radiocarbon ages and tephra dates allow to identify and characterize the main sedimentary processes occurring in the lake over the last 8 kyr. In addition, proxy data (C and N isotopes and XRF scan data) from the laminated hemipelagic interval provide a reliable record of past variability in the westerly wind field as

  9. Uranium series dating of human skeletal remains from the Del Mar and Sunnyvale sites, California

    SciTech Connect

    Bischoff, J.L.; Rosenbauer, R.J.

    1981-08-28

    Uranium series analyses of human bone samples from the Del Mar and Sunnyvale sites indicate ages of 11,000 and 8300 years, respectively. The dates are supported by internal concordancy between thorium-230 and protactinium-231 decay systems. These ages are significantly younger than the estimates of 48,000 and 70,000 years based on amino acid racemization, and indicate that the individuals could derive from the population waves that came across the Bering Strait during the last sea-level low.

  10. Anomalous ocean load tide signal observed in lake-level variations in Tierra del Fuego

    NASA Astrophysics Data System (ADS)

    Richter, A.; Hormaechea, J. L.; Dietrich, R.; Perdomo, R.; Fritsche, M.; Del Cogliano, D.; Liebsch, G.; Mendoza, L.

    2009-03-01

    We demonstrate the application of a 100 km long lake as a sensor for studying the tidal effects on Tierra del Fuego main island. The lake-level variations observed in Lago Fagnano reflect both the direct response to the tidal potential and the indirect effect of the ocean tidal loading. Modeling both contributions explains the observed tidal signal in the lake to about 70%. Underestimated model load tide amplitudes are found to be probably responsible for the remaining difference. We interpret this discrepancy as a hint for regional elastic lithosphere properties differing substantially from those represented by currently available global models.

  11. Pliocene Transgression in the Western Mediterranean Sea: Strontium Isotopes from Cuevas Del Almanzora (Se Spain)

    NASA Astrophysics Data System (ADS)

    Müller, Daniel W.

    1993-02-01

    The deposition of marine sediments in the deep Mediterranean basins following the Messinian salinity crisis ("Zanclean Deluge") began at 4.9 Ma and continued until normal marine conditions prevailed at 4.6 Ma. The Betic Strait of southeast Spain, the Rif Strait of northern Morocco, and the Strait of Gibraltar have been postulated as possible entry ways for the marine waters into the Mediterranean. Two possible explanations have been offered for the timing of the deposition of marine hemipelagic marls in the Vera Basin (Cuevas del Almanzora section) within the Betic Strait: (1) early Pliocene, representing the "Zanclean Deluge" (Cita et al., 1980), (2) Messinian (˜5.7 Ma), representing the last marine stage before the Messinian salinity crisis (Benson and Rakic-El Bied, 1991; Benson et al., 1991). The strontium isotopic ratio on mixed assemblages of foraminifers from these marine marls was determined in order to assess their ages. The average 87Sr/86Sr (0.709033±24) of the seven measured samples is, compared to the base of the Miocene/Pliocene boundary stratotype at Capo Rossello, Sicily, higher by 38 × 10-6 and yields an age of 4.6±0.5 Ma when compared to the established open ocean Sr seawater curve. The determined age indicates that (1) the first 3.6 m of marine deposits of the Cuevas del Almanzora section sensu Cita et al. (1980) including the passage zone are Pliocene, (2) the earliest marine Pliocene might not be represented at Cuevas del Almanzora indicating that this marginal basin at the edge of the Mediterranean Sea, yet within the former Betic Strait, was filled progressively by a marine transgression originating from the Mediterranean Sea around 4.6 Ma. The absence of lowermost Pliocene sediments could suggest that the Betic Strait did not serve as a conduit for the water masses entering the Mediterranean basins during the early Pliocene; and (3) the presence of an early evolutionary stage of Globorotalia margaritae in the Moroccan Bou Regreg section

  12. Evaluation of the Del Mar Avionics automatic ambulatory blood pressure-recording device.

    PubMed

    Sheps, S G; Elveback, L R; Close, E L; Kleven, M K; Bissen, C

    1981-12-01

    We have the opportunity to evaluate a portable ambulatory device for the recording of sequential indirect arterial blood pressure and continuous electrocardiogram (Del Mar Avionics automatic ambulatory blood pressure recording device). With careful attention to technique, only 11% of systolic and 5% of diastolic blood pressure readings differed by more than 10 mm Hg as compared with a trained technician's observations simultaneously in the same arm. The device has been useful in the evaluation of borderline (labile) hypertension, hypertensive drug therapy programs, and various episodic cardiovascular phenomena--for example, vasodepressor syncope and pheochromocytoma crises.

  13. Rotating Kaluza-Klein multi-black holes with Gödel parameter

    NASA Astrophysics Data System (ADS)

    Matsuno, Ken; Ishihara, Hideki; Nakagawa, Toshiharu; Tomizawa, Shinya

    2008-09-01

    We obtain new five-dimensional supersymmetric rotating multi-Kaluza-Klein black hole solutions with the Gödel parameter in the Einstein-Maxwell system with a Chern-Simons term. These solutions have no closed timelike curve outside the black hole horizons. At infinity, the space-time is effectively four-dimensional. Each horizon admits various lens space topologies L(n;1)=S3/Zn in addition to a round S3. The space-time can have outer ergoregions disjointed from the black hole horizons, as well as inner ergoregions attached to each horizon. We discuss the rich structures of ergoregions.

  14. Heavy metal concentrations in litteral sediments from the Beagle Channel, Tierra del Fuego, Argentina.

    PubMed

    Amin, O; Ferrer, L; Marcovecchio, J

    1996-07-01

    For the first time the concentration of trace metals (Fe, Pb, Cu, Zn, Cd and total Hg) of sediments from the coastal zone of the Beagle Channel (Tierra del Fuego, in Southern Argentina) were measured. Atomic absorption spectrophotometry was utilized in order to determine the metal contents. The level of metals as observed in the sediments was recognized as the natural background, even though the use of normalization of lead, copper, and zinc to iron allowed the identification of the main sources of metal pollution for this environment. In order to develop future environmental monitoring programmes for the area of Ushuaia city and the Beagle Channel, the present results need to be considered.

  15. Uranium series dating of human skeletal remains from the Del Mar and Sunnyvale sites, California

    USGS Publications Warehouse

    Bischoff, J.L.; Rosenbauer, R.J.

    1981-01-01

    Uranium series analyses of human bone samples from the Del Mar and Sunnyvale sites indicate ages of 11,000 and 8,300 years, respectively. The dates are supported by internal concordancy between thorium-230 and protactinium-231 decay systems. These ages are significantly younger than the estimates of 48,000 and 70,000 years based on amino acid racemization, and indicate that the individuals could derive from the population waves that came across the Bering Strait during the last sea-level low. Copyright ?? 1981 AAAS.

  16. 2.3-11.6 Micron Measurements of Nova Del 2013 Consistent with Presence of Dust

    NASA Astrophysics Data System (ADS)

    Cass, A. C.; Carlon, R. L.; Corgan, D. T.; Dykhoff, D. A.; Gehrz, R. D.; Shenoy, D. P.

    2013-11-01

    Our 2.3-11.6 micron measurements of Nova Del 2013 on 24.04 November 2013 UT using an As:Si bolometer mounted on the 0.76-m infrared telescope of the University of Minnesota's O'Brien Observatory (Marine on St. Croix, Minnesota, USA) yielded the following magnitudes: K = +5.24 +/- 0.15, L = +3.25 +/- 0.38, M = +2.00 +/- 0.26, [10.3] = -0.17 +/- 0.38, and [11.6] = -0.19 +/- 0.21. An additional measurement on 19.08 November 2013 yielded [10.3] = -0.10 +/- 0.36.

  17. L-Band Measurement of Nova Del 2013 Consistent with Presence of Dust

    NASA Astrophysics Data System (ADS)

    Cass, A. C.; Carlon, R. L.; Corgan, D. T.; Dykhoff, D. A.; Gehrz, R. D.; Shenoy, D. P.

    2013-09-01

    An L-band measurement of Nova Del 2013 on 29.17 September 2013 UT using an As:Si bolometer mounted on the 0.76-m infrared telescope of the University of Minnesota's O'Brien Observatory (Marine on St. Croix, Minnesota, USA) yielded a magnitude of L = +2.6 +/- 0.3. Vega (alpha Lyrae) was used as the standard star. This flux level is consistent with a small amount of dust having formed recently as reported in ATEL 5431.

  18. Matuyama-age lithic tools from the Sima del Elefante site, Atapuerca (northern Spain).

    PubMed

    Parés, Josep M; Pérez-González, Alfredo; Rosas, Antonio; Benito, A; Bermúdez de Castro, J M; Carbonell, E; Huguet, R

    2006-02-01

    Paleomagnetic results obtained from the sedimentary fill at the Sima del Elefante site in Atapuerca, Spain, reveal a geomagnetic reversal, interpreted as the Matuyama-Brunhes boundary (0.78 Ma). The uppermost lithostratigraphic units (E17 through E19), which contain Mode II and III archaeological assemblages, display normal polarity magnetization, whereas the six lowermost units (E9 through E16) yield negative latitudinal virtual geomagnetic pole positions. Units E9 through E13, all of which display reverse magnetic polarity, contain Mode I (Oldowan) lithic tools, testifying to the presence of humans in the early Pleistocene (0.78-1.77 Ma). PMID:16249015

  19. Cáncer de ovario, de trompa de Falopio y primario de peritoneo—Versión para pacientes

    Cancer.gov

    Información del Instituto Nacional del Cáncer sobre el tratamiento, la prevención, la genética, las causas y los exámenes de detección del cáncer de ovario, así como referencias a estudios clínicos, investigación, estadísticas y otros temas relacionados.

  20. Cáncer de cuello uterino—Versión para profesionales de salud

    Cancer.gov

    Información del Instituto Nacional del Cáncer para profesionales de salud sobre el tratamiento, la prevención, las causas y los exámenes de detección del cáncer de cuello uterino, así como referencias a estudios clínicos, investigación, estadísticas y otros temas relacionados.