Multiparameter measurement using a double-Y-shaped suspended-core fiber in a fiber loop configuration

NASA Astrophysics Data System (ADS)

Silva, S. F.; Baierl, H.; Auguste, J.-L.; Jamier, R.; Roy, P.; Baptista, J. M.; Santos, J. L.; Frazão, O.

2014-05-01

Cardiovascular health of the human population is a major concern for medical clinicians, with cardiovascular diseases responsible for 48% of all deaths worldwide, according to the World Health Organisation. Therefore the development of new practicable and economical diagnostic tools to scrutinise the cardiovascular health of humans is a major driver for clinicians. We offer a new technique to obtain seismocardiographic signals covering both ballistocardiography (below 20Hz) and audible heart sounds (20Hz upwards). The detection scheme is based upon an array of curvature/displacement sensors using fibre optic long period gratings interrogated using a variation of the derivative spectroscopy interrogation technique

Marginal Shape Deep Learning: Applications to Pediatric Lung Field Segmentation.

PubMed

Mansoor, Awais; Cerrolaza, Juan J; Perez, Geovanny; Biggs, Elijah; Nino, Gustavo; Linguraru, Marius George

2017-02-11

Representation learning through deep learning (DL) architecture has shown tremendous potential for identification, localization, and texture classification in various medical imaging modalities. However, DL applications to segmentation of objects especially to deformable objects are rather limited and mostly restricted to pixel classification. In this work, we propose marginal shape deep learning (MaShDL), a framework that extends the application of DL to deformable shape segmentation by using deep classifiers to estimate the shape parameters. MaShDL combines the strength of statistical shape models with the automated feature learning architecture of DL. Unlike the iterative shape parameters estimation approach of classical shape models that often leads to a local minima, the proposed framework is robust to local minima optimization and illumination changes. Furthermore, since the direct application of DL framework to a multi-parameter estimation problem results in a very high complexity, our framework provides an excellent run-time performance solution by independently learning shape parameter classifiers in marginal eigenspaces in the decreasing order of variation. We evaluated MaShDL for segmenting the lung field from 314 normal and abnormal pediatric chest radiographs and obtained a mean Dice similarity coefficient of 0.927 using only the four highest modes of variation (compared to 0.888 with classical ASM 1 (p-value=0.01) using same configuration). To the best of our knowledge this is the first demonstration of using DL framework for parametrized shape learning for the delineation of deformable objects.

Marginal shape deep learning: applications to pediatric lung field segmentation

NASA Astrophysics Data System (ADS)

Mansoor, Awais; Cerrolaza, Juan J.; Perez, Geovany; Biggs, Elijah; Nino, Gustavo; Linguraru, Marius George

2017-02-01

Representation learning through deep learning (DL) architecture has shown tremendous potential for identification, local- ization, and texture classification in various medical imaging modalities. However, DL applications to segmentation of objects especially to deformable objects are rather limited and mostly restricted to pixel classification. In this work, we propose marginal shape deep learning (MaShDL), a framework that extends the application of DL to deformable shape segmentation by using deep classifiers to estimate the shape parameters. MaShDL combines the strength of statistical shape models with the automated feature learning architecture of DL. Unlike the iterative shape parameters estimation approach of classical shape models that often leads to a local minima, the proposed framework is robust to local minima optimization and illumination changes. Furthermore, since the direct application of DL framework to a multi-parameter estimation problem results in a very high complexity, our framework provides an excellent run-time performance solution by independently learning shape parameter classifiers in marginal eigenspaces in the decreasing order of variation. We evaluated MaShDL for segmenting the lung field from 314 normal and abnormal pediatric chest radiographs and obtained a mean Dice similarity coefficient of 0:927 using only the four highest modes of variation (compared to 0:888 with classical ASM1 (p-value=0:01) using same configuration). To the best of our knowledge this is the first demonstration of using DL framework for parametrized shape learning for the delineation of deformable objects.

Marginal Shape Deep Learning: Applications to Pediatric Lung Field Segmentation

PubMed Central

Mansoor, Awais; Cerrolaza, Juan J.; Perez, Geovanny; Biggs, Elijah; Nino, Gustavo; Linguraru, Marius George

2017-01-01

Representation learning through deep learning (DL) architecture has shown tremendous potential for identification, localization, and texture classification in various medical imaging modalities. However, DL applications to segmentation of objects especially to deformable objects are rather limited and mostly restricted to pixel classification. In this work, we propose marginal shape deep learning (MaShDL), a framework that extends the application of DL to deformable shape segmentation by using deep classifiers to estimate the shape parameters. MaShDL combines the strength of statistical shape models with the automated feature learning architecture of DL. Unlike the iterative shape parameters estimation approach of classical shape models that often leads to a local minima, the proposed framework is robust to local minima optimization and illumination changes. Furthermore, since the direct application of DL framework to a multi-parameter estimation problem results in a very high complexity, our framework provides an excellent run-time performance solution by independently learning shape parameter classifiers in marginal eigenspaces in the decreasing order of variation. We evaluated MaShDL for segmenting the lung field from 314 normal and abnormal pediatric chest radiographs and obtained a mean Dice similarity coefficient of 0.927 using only the four highest modes of variation (compared to 0.888 with classical ASM1 (p-value=0.01) using same configuration). To the best of our knowledge this is the first demonstration of using DL framework for parametrized shape learning for the delineation of deformable objects. PMID:28592911

Characterization of a Low-Cost Multi-Parameter Sensor for Resource Applications: Preprint

DOE Office of Scientific and Technical Information (OSTI.GOV)

Habte, Aron M; Sengupta, Manajit; Andreas, Afshin M

Low-cost multi-parameter sensing and measurement devices enable cost-effective monitoring of the functional, operational reliability, efficiency, and resiliency of the electrical grid. The National Renewable Research Laboratory (NREL) Solar Radiation Research Laboratory (SRRL), in collaboration with Arable Labs Inc., deployed Arable Lab's Mark multi-parameter sensor system. The unique suite of system sensors measures the down-welling and upwelling shortwave solar resource and longwave radiation, humidity, air temperature, and ground temperature. This study describes the shortwave calibration, characteriza-tion, and validation of measurement accuracy of this instrument by comparison with existing instruments that are part of NREL-SRRL's Baseline Measurement System.

Injection of Contaminants into a Simulated Water Distribution System Equipped with Continuous Multi-Parameter Water Monitors

EPA Science Inventory

The U.S. EPA’s Technology Testing and Evaluation Program has been charged by EPA to evaluate the performance of commercially available water security-related technologies. Multi-parameter water monitors for distributions systems have been evaluated as such a water security techn...

Inverting Image Data For Optical Testing And Alignment

NASA Technical Reports Server (NTRS)

Shao, Michael; Redding, David; Yu, Jeffrey W.; Dumont, Philip J.

1993-01-01

Data from images produced by slightly incorrectly figured concave primary mirror in telescope processed into estimate of spherical aberration of mirror, by use of algorithm finding nonlinear least-squares best fit between actual images and synthetic images produced by multiparameter mathematical model of telescope optical system. Estimated spherical aberration, in turn, converted into estimate of deviation of reflector surface from nominal precise shape. Algorithm devised as part of effort to determine error in surface figure of primary mirror of Hubble space telescope, so corrective lens designed. Modified versions of algorithm also used to find optical errors in other components of telescope or of other optical systems, for purposes of testing, alignment, and/or correction.

On-fiber plasmonic interferometer for multi-parameter sensing

DOE PAGES

Zhang, Zhijian; Chen, Yongyao; Liu, Haijun; ...

2015-01-01

We demonstrate a novel miniature multi-parameter sensing device based on a plasmonic interferometer fabricated on a fiber facet in the optical communication wavelength range. This device enables the coupling between surface plasmon resonance and plasmonic interference in the structure, which are the two essential mechanisms for multi-parameter sensing. We experimentally show that these two mechanisms have distinctive responses to temperature and refractive index, rendering the device the capability of simultaneous temperature and refractive index measurement on an ultra-miniature form factor. A high refractive index sensitivity of 220 nm per refractive index unit (RIU) and a high temperature sensitivity of –60more » pm/ °C is achieved with our device.« less

Multi-parameter phenotypic profiling: using cellular effects to characterize small-molecule compounds.

PubMed

Feng, Yan; Mitchison, Timothy J; Bender, Andreas; Young, Daniel W; Tallarico, John A

2009-07-01

Multi-parameter phenotypic profiling of small molecules provides important insights into their mechanisms of action, as well as a systems level understanding of biological pathways and their responses to small molecule treatments. It therefore deserves more attention at an early step in the drug discovery pipeline. Here, we summarize the technologies that are currently in use for phenotypic profiling--including mRNA-, protein- and imaging-based multi-parameter profiling--in the drug discovery context. We think that an earlier integration of phenotypic profiling technologies, combined with effective experimental and in silico target identification approaches, can improve success rates of lead selection and optimization in the drug discovery process.

A fast multiparameter MRI approach for acute stroke assessment on a 3T clinical scanner: preliminary results in a non-human primate model with transient ischemic occlusion.

PubMed

Zhang, Xiaodong; Tong, Frank; Li, Chun-Xia; Yan, Yumei; Nair, Govind; Nagaoka, Tsukasa; Tanaka, Yoji; Zola, Stuart; Howell, Leonard

2014-04-01

Many MRI parameters have been explored and demonstrated the capability or potential to evaluate acute stroke injury, providing anatomical, microstructural, functional, or neurochemical information for diagnostic purposes and therapeutic development. However, the application of multiparameter MRI approach is hindered in clinic due to the very limited time window after stroke insult. Parallel imaging technique can accelerate MRI data acquisition dramatically and has been incorporated in modern clinical scanners and increasingly applied for various diagnostic purposes. In the present study, a fast multiparameter MRI approach including structural T1-weighted imaging (T1W), T2-weighted imaging (T2W), diffusion tensor imaging (DTI), T2-mapping, proton magnetic resonance spectroscopy, cerebral blood flow (CBF), and magnetization transfer (MT) imaging, was implemented and optimized for assessing acute stroke injury on a 3T clinical scanner. A macaque model of transient ischemic stroke induced by a minimal interventional approach was utilized for evaluating the multiparameter MRI approach. The preliminary results indicate the surgical procedure successfully induced ischemic occlusion in the cortex and/or subcortex in adult macaque monkeys (n=4). Application of parallel imaging technique substantially reduced the scanning duration of most MRI data acquisitions, allowing for fast and repeated evaluation of acute stroke injury. Hence, the use of the multiparameter MRI approach with up to five quantitative measures can provide significant advantages in preclinical or clinical studies of stroke disease.

MURI: Optimal Quantum Dynamic Discrimination of Chemical and Biological Agents

DTIC Science & Technology

2008-06-12

multiparameter) Hilbert space for enhanced detection and classification: an application of receiver operating curve statistics to laser-based mass...Adaptive reshaping of objects in (multiparameter) Hilbert space for enhanced detection and classification: an application of receiver operating curve...Doctoral Associate Muhannad Zamari, Graduate Student Ilya Greenberg , Computer Consultant Getahun Menkir, Graduate Student Lalinda Palliyaguru, Graduate

Detecting ordered small molecule drug aggregates in live macrophages: a multi-parameter microscope image data acquisition and analysis strategy

PubMed Central

Rzeczycki, Phillip; Yoon, Gi Sang; Keswani, Rahul K.; Sud, Sudha; Stringer, Kathleen A.; Rosania, Gus R.

2017-01-01

Following prolonged administration, certain orally bioavailable but poorly soluble small molecule drugs are prone to precipitate out and form crystal-like drug inclusions (CLDIs) within the cells of living organisms. In this research, we present a quantitative multi-parameter imaging platform for measuring the fluorescence and polarization diattenuation signals of cells harboring intracellular CLDIs. To validate the imaging system, the FDA-approved drug clofazimine (CFZ) was used as a model compound. Our results demonstrated that a quantitative multi-parameter microscopy image analysis platform can be used to study drug sequestering macrophages, and to detect the formation of ordered molecular aggregates formed by poorly soluble small molecule drugs in animals. PMID:28270989

Detecting ordered small molecule drug aggregates in live macrophages: a multi-parameter microscope image data acquisition and analysis strategy.

PubMed

Rzeczycki, Phillip; Yoon, Gi Sang; Keswani, Rahul K; Sud, Sudha; Stringer, Kathleen A; Rosania, Gus R

2017-02-01

Following prolonged administration, certain orally bioavailable but poorly soluble small molecule drugs are prone to precipitate out and form crystal-like drug inclusions (CLDIs) within the cells of living organisms. In this research, we present a quantitative multi-parameter imaging platform for measuring the fluorescence and polarization diattenuation signals of cells harboring intracellular CLDIs. To validate the imaging system, the FDA-approved drug clofazimine (CFZ) was used as a model compound. Our results demonstrated that a quantitative multi-parameter microscopy image analysis platform can be used to study drug sequestering macrophages, and to detect the formation of ordered molecular aggregates formed by poorly soluble small molecule drugs in animals.

Characterization of a Low-Cost Multiparameter Sensor for Solar Resource Applications

DOE Office of Scientific and Technical Information (OSTI.GOV)

Habte, Aron M; Sengupta, Manajit; Andreas, Afshin M

Low-cost, multiparameter sensing and measurement devices enable cost-effective monitoring of the functional, operational reliability, efficiency, and resiliency of the electric grid. The National Renewable Research Laboratory (NREL) Solar Radiation Research Laboratory (SRRL), in collaboration with Arable Labs, Inc., deployed Arable Lab's Mark multiparameter sensor system. The device measures the downwelling and upwelling shortwave solar resource and longwave radiation, humidity, air temperature, and ground temperature. The system is also equipped with six downward-and upward-facing narrowband spectrometer channels that measure spectral radiation and surface spectral reflectance. This study describes the shortwave calibration, characterization, and validation of measurement accuracy of this instrument bymore » comparison with existing instruments that are part of NREL-SRRL's Baseline Measurement System.« less

Stick or Switch: A Selection Heuristic Predicts when People Take the Perspective of Others or Communicate Egocentrically.

PubMed

Rogers, Shane L; Fay, Nicolas

2016-01-01

This paper examines a cognitive mechanism that drives perspective-taking and egocentrism in interpersonal communication. Using a conceptual referential communication task, in which participants describe a range of abstract geometric shapes, Experiment 1 shows that perspective-taking and egocentric communication are frequent communication strategies. Experiment 2 tests a selection heuristic account of perspective-taking and egocentric communication. It uses participants' shape description ratings to predict their communication strategy. Participants' communication strategy was predicted by how informative they perceived the different shape descriptions to be. When participants' personal shape description was perceived to be more informative than their addressee's shape description, there was a strong bias to communicate egocentrically. By contrast, when their addressee's shape description was perceived to be more informative, there was a strong bias to take their addressee's perspective. When the shape descriptions were perceived to be equally informative, there was a moderate bias to communicate egocentrically. This simple, but powerful, selection heuristic may be critical to the cumulative cultural evolution of human communication systems, and cumulative cultural evolution more generally.

Multiparameter measurement utilizing poloidal polarimeter for burning plasma reactor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Imazawa, Ryota; Kawano, Yasunori; Itami, Kiyoshi

2014-08-21

The authors have made the basic and applied research on the polarimeter for plasma diagnostics. Recently, the authors have proposed an application of multiparameter measurement (magnetic field, B, electron density, n{sub e}, electron temperature, T{sub e}, and total plasma current, I{sub p}) utilizing polarimeter to future fusion reactors. In this proceedings, the brief review of the polarimeter, the principle of the multiparameter measurement and the progress of the research on the multiparameter measurement are explained. The measurement method that the authors have proposed is suitable for the reactor for the following reasons; multiparameters can be obtained from a small numbermore » of diagnostics, the proposed method does not depend on time-history, and far-infrared light utilized by the polarimeter is less sensitive to degradation of of optical components. Taking into account the measuring error, performance assessment of the proposed method was carried. Assuming that the error of Δθ and Δε were 0.1° and 0.6°, respectively, the error of reconstructed j{sub φ}, n{sub e} and T{sub e} were 12 %, 8.4 % and 31 %, respectively. This study has shown that the reconstruction error can be decreased by increasing the number of the wavelength of the probing laser and by increasing the number of the viewing chords. For example, By increasing the number of viewing chords to forty-five, the error of j{sub φ}, n{sub e} and T{sub e} were reduced to 4.4 %, 4.4 %, and 17 %, respectively.« less

Inter-observer agreement of a multi-parameter campsite monitoring program on the Dixie National Forest, Utah

Treesearch

Nicholas J. Glidden; Martha E. Lee

2007-01-01

Precision is crucial to campsite monitoring programs. Yet, little empirical research has ever been published on the level of precision of this type of monitoring programs. The purpose of this study was to evaluate the level of agreement between observers of campsite impacts using a multi-parameter campsite monitoring program. Thirteen trained observers assessed 16...

Resolution of VTI anisotropy with elastic full-waveform inversion: theory and basic numerical examples

NASA Astrophysics Data System (ADS)

Podgornova, O.; Leaney, S.; Liang, L.

2018-07-01

Extracting medium properties from seismic data faces some limitations due to the finite frequency content of the data and restricted spatial positions of the sources and receivers. Some distributions of the medium properties make low impact on the data (including none). If these properties are used as the inversion parameters, then the inverse problem becomes overparametrized, leading to ambiguous results. We present an analysis of multiparameter resolution for the linearized inverse problem in the framework of elastic full-waveform inversion. We show that the spatial and multiparameter sensitivities are intertwined and non-sensitive properties are spatial distributions of some non-trivial combinations of the conventional elastic parameters. The analysis accounts for the Hessian information and frequency content of the data; it is semi-analytical (in some scenarios analytical), easy to interpret and enhances results of the widely used radiation pattern analysis. Single-type scattering is shown to have limited sensitivity, even for full-aperture data. Finite-frequency data lose multiparameter sensitivity at smooth and fine spatial scales. Also, we establish ways to quantify a spatial-multiparameter coupling and demonstrate that the theoretical predictions agree well with the numerical results.

The Multi-Parameter Wireless Sensing System (MPwise): Its Description and Application to Earthquake Risk Mitigation.

PubMed

Boxberger, Tobias; Fleming, Kevin; Pittore, Massimiliano; Parolai, Stefano; Pilz, Marco; Mikulla, Stefan

2017-10-20

The Multi-Parameter Wireless Sensing (MPwise) system is an innovative instrumental design that allows different sensor types to be combined with relatively high-performance computing and communications components. These units, which incorporate off-the-shelf components, can undertake complex information integration and processing tasks at the individual unit or node level (when used in a network), allowing the establishment of networks that are linked by advanced, robust and rapid communications routing and network topologies. The system (and its predecessors) was originally designed for earthquake risk mitigation, including earthquake early warning (EEW), rapid response actions, structural health monitoring, and site-effect characterization. For EEW, MPwise units are capable of on-site, decentralized, independent analysis of the recorded ground motion and based on this, may issue an appropriate warning, either by the unit itself or transmitted throughout a network by dedicated alarming procedures. The multi-sensor capabilities of the system allow it to be instrumented with standard strong- and weak-motion sensors, broadband sensors, MEMS (namely accelerometers), cameras, temperature and humidity sensors, and GNSS receivers. In this work, the MPwise hardware, software and communications schema are described, as well as an overview of its possible applications. While focusing on earthquake risk mitigation actions, the aim in the future is to expand its capabilities towards a more multi-hazard and risk mitigation role. Overall, MPwise offers considerable flexibility and has great potential in contributing to natural hazard risk mitigation.

The Multi-Parameter Wireless Sensing System (MPwise): Its Description and Application to Earthquake Risk Mitigation

PubMed Central

Boxberger, Tobias; Fleming, Kevin; Pittore, Massimiliano; Parolai, Stefano; Pilz, Marco; Mikulla, Stefan

2017-01-01

The Multi-Parameter Wireless Sensing (MPwise) system is an innovative instrumental design that allows different sensor types to be combined with relatively high-performance computing and communications components. These units, which incorporate off-the-shelf components, can undertake complex information integration and processing tasks at the individual unit or node level (when used in a network), allowing the establishment of networks that are linked by advanced, robust and rapid communications routing and network topologies. The system (and its predecessors) was originally designed for earthquake risk mitigation, including earthquake early warning (EEW), rapid response actions, structural health monitoring, and site-effect characterization. For EEW, MPwise units are capable of on-site, decentralized, independent analysis of the recorded ground motion and based on this, may issue an appropriate warning, either by the unit itself or transmitted throughout a network by dedicated alarming procedures. The multi-sensor capabilities of the system allow it to be instrumented with standard strong- and weak-motion sensors, broadband sensors, MEMS (namely accelerometers), cameras, temperature and humidity sensors, and GNSS receivers. In this work, the MPwise hardware, software and communications schema are described, as well as an overview of its possible applications. While focusing on earthquake risk mitigation actions, the aim in the future is to expand its capabilities towards a more multi-hazard and risk mitigation role. Overall, MPwise offers considerable flexibility and has great potential in contributing to natural hazard risk mitigation. PMID:29053608

Control-enhanced multiparameter quantum estimation

NASA Astrophysics Data System (ADS)

Liu, Jing; Yuan, Haidong

2017-10-01

Most studies in multiparameter estimation assume the dynamics is fixed and focus on identifying the optimal probe state and the optimal measurements. In practice, however, controls are usually available to alter the dynamics, which provides another degree of freedom. In this paper we employ optimal control methods, particularly the gradient ascent pulse engineering (GRAPE), to design optimal controls for the improvement of the precision limit in multiparameter estimation. We show that the controlled schemes are not only capable to provide a higher precision limit, but also have a higher stability to the inaccuracy of the time point performing the measurements. This high time stability will benefit the practical metrology, where it is hard to perform the measurement at a very accurate time point due to the response time of the measurement apparatus.

Creating Body Shapes From Verbal Descriptions by Linking Similarity Spaces.

PubMed

Hill, Matthew Q; Streuber, Stephan; Hahn, Carina A; Black, Michael J; O'Toole, Alice J

2016-11-01

Brief verbal descriptions of people's bodies (e.g., "curvy," "long-legged") can elicit vivid mental images. The ease with which these mental images are created belies the complexity of three-dimensional body shapes. We explored the relationship between body shapes and body descriptions and showed that a small number of words can be used to generate categorically accurate representations of three-dimensional bodies. The dimensions of body-shape variation that emerged in a language-based similarity space were related to major dimensions of variation computed directly from three-dimensional laser scans of 2,094 bodies. This relationship allowed us to generate three-dimensional models of people in the shape space using only their coordinates on analogous dimensions in the language-based description space. Human descriptions of photographed bodies and their corresponding models matched closely. The natural mapping between the spaces illustrates the role of language as a concise code for body shape that captures perceptually salient global and local body features. © The Author(s) 2016.

Density reconstruction in multiparameter elastic full-waveform inversion

NASA Astrophysics Data System (ADS)

Sun, Min'ao; Yang, Jizhong; Dong, Liangguo; Liu, Yuzhu; Huang, Chao

2017-12-01

Elastic full-waveform inversion (EFWI) is a quantitative data fitting procedure that recovers multiple subsurface parameters from multicomponent seismic data. As density is involved in addition to P- and S-wave velocities, the multiparameter EFWI suffers from more serious tradeoffs. In addition, compared with P- and S-wave velocities, the misfit function is less sensitive to density perturbation. Thus, a robust density reconstruction remains a difficult problem in multiparameter EFWI. In this paper, we develop an improved scattering-integral-based truncated Gauss-Newton method to simultaneously recover P- and S-wave velocities and density in EFWI. In this method, the inverse Gauss-Newton Hessian has been estimated by iteratively solving the Gauss-Newton equation with a matrix-free conjugate gradient algorithm. Therefore, it is able to properly handle the parameter tradeoffs. To give a detailed illustration of the tradeoffs between P- and S-wave velocities and density in EFWI, wavefield-separated sensitivity kernels and the Gauss-Newton Hessian are numerically computed, and their distribution characteristics are analyzed. Numerical experiments on a canonical inclusion model and a modified SEG/EAGE Overthrust model have demonstrated that the proposed method can effectively mitigate the tradeoff effects, and improve multiparameter gradients. Thus, a high convergence rate and an accurate density reconstruction can be achieved.

Azimuthally Anisotropic 3D Velocity Continuation

DOE PAGES

Burnett, William; Fomel, Sergey

2011-01-01

We extend time-domain velocity continuation to the zero-offset 3D azimuthally anisotropic case. Velocity continuation describes how a seismic image changes given a change in migration velocity. This description turns out to be of a wave propagation process, in which images change along a velocity axis. In the anisotropic case, the velocity model is multiparameter. Therefore, anisotropic image propagation is multidimensional. We use a three-parameter slowness model, which is related to azimuthal variations in velocity, as well as their principal directions. This information is useful for fracture and reservoir characterization from seismic data. We provide synthetic diffraction imaging examples to illustratemore » the concept and potential applications of azimuthal velocity continuation and to analyze the impulse response of the 3D velocity continuation operator.« less

Traditional medicines and globalization: current and future perspectives in ethnopharmacology.

PubMed

Leonti, Marco; Casu, Laura

2013-01-01

The ethnopharmacological approach toward the understanding and appraisal of traditional and herbal medicines is characterized by the inclusions of the social as well as the natural sciences. Anthropological field-observations describing the local use of nature-derived medicines are the basis for ethnopharmacological enquiries. The multidisciplinary scientific validation of indigenous drugs is of relevance to modern societies at large and helps to sustain local health care practices. Especially with respect to therapies related to aging related, chronic and infectious diseases traditional medicines offer promising alternatives to biomedicine. Bioassays applied in ethnopharmacology represent the molecular characteristics and complexities of the disease or symptoms for which an indigenous drug is used in "traditional" medicine to variable depth and extent. One-dimensional in vitro approaches rarely cope with the complexity of human diseases and ignore the concept of polypharmacological synergies. The recent focus on holistic approaches and systems biology in medicinal plant research represents the trend toward the description and the understanding of complex multi-parameter systems. Ethnopharmacopoeias are non-static cultural constructs shaped by belief and knowledge systems. Intensified globalization and economic liberalism currently accelerates the interchange between local and global pharmacopoeias via international trade, television, the World Wide Web and print media. The increased infiltration of newly generated biomedical knowledge and introduction of "foreign" medicines into local pharmacopoeias leads to syncretic developments and generates a feedback loop. While modern and post-modern cultures and knowledge systems adapt and transform the global impact, they become more relevant for ethnopharmacology. Moreover, what is traditional, alternative or complementary medicine depends on the adopted historic-cultural perspective.

Traditional medicines and globalization: current and future perspectives in ethnopharmacology

PubMed Central

Leonti, Marco; Casu, Laura

2013-01-01

The ethnopharmacological approach toward the understanding and appraisal of traditional and herbal medicines is characterized by the inclusions of the social as well as the natural sciences. Anthropological field-observations describing the local use of nature-derived medicines are the basis for ethnopharmacological enquiries. The multidisciplinary scientific validation of indigenous drugs is of relevance to modern societies at large and helps to sustain local health care practices. Especially with respect to therapies related to aging related, chronic and infectious diseases traditional medicines offer promising alternatives to biomedicine. Bioassays applied in ethnopharmacology represent the molecular characteristics and complexities of the disease or symptoms for which an indigenous drug is used in “traditional” medicine to variable depth and extent. One-dimensional in vitro approaches rarely cope with the complexity of human diseases and ignore the concept of polypharmacological synergies. The recent focus on holistic approaches and systems biology in medicinal plant research represents the trend toward the description and the understanding of complex multi-parameter systems. Ethnopharmacopoeias are non-static cultural constructs shaped by belief and knowledge systems. Intensified globalization and economic liberalism currently accelerates the interchange between local and global pharmacopoeias via international trade, television, the World Wide Web and print media. The increased infiltration of newly generated biomedical knowledge and introduction of “foreign” medicines into local pharmacopoeias leads to syncretic developments and generates a feedback loop. While modern and post-modern cultures and knowledge systems adapt and transform the global impact, they become more relevant for ethnopharmacology. Moreover, what is traditional, alternative or complementary medicine depends on the adopted historic-cultural perspective. PMID:23898296

Multiparameter estimation with single photons—linearly-optically generated quantum entanglement beats the shotnoise limit

NASA Astrophysics Data System (ADS)

You, Chenglong; Adhikari, Sushovit; Chi, Yuxi; LaBorde, Margarite L.; Matyas, Corey T.; Zhang, Chenyu; Su, Zuen; Byrnes, Tim; Lu, Chaoyang; Dowling, Jonathan P.; Olson, Jonathan P.

2017-12-01

It was suggested in (Motes et al 2015 Phys. Rev. Lett. 114 170802) that optical networks with relatively inexpensive overheads—single photon Fock states, passive optical elements, and single photon detection—can show significant improvements over classical strategies for single-parameter estimation, when the number of modes in the network is small (n< 7). A similar case was made in (Humphreys et al 2013 Phys. Rev. Lett. 111 070403) for multi-parameter estimation, where measurement is instead made using photon-number resolving detectors. In this paper, we analytically compute the quantum Cramér-Rao bound to show these networks can have a constant-factor quantum advantage in multi-parameter estimation for even large number of modes. Additionally, we provide a simplified measurement scheme using only single-photon (on-off) detectors that is capable of approximately obtaining this sensitivity for a small number of modes.

Subharmonic emissions from microbubbles: effect of the driving pulse shape.

PubMed

Biagi, Elena; Breschi, Luca; Vannacci, Enrico; Masotti, Leonardo

2006-11-01

The aims of this work are to investigate the response of the ultrasonic contrast agents (UCA) insonified by different arbitrary-shaped pulses at different acoustic pressures and concentration of the contrast agent focusing on subharmonic emission. A transmission setup was developed in order to insonify the contrast agent contained in a measurement chamber. The transmitted ultrasonic signals were generated by an arbitrary wave generator connected to a linear power amplifier able to drive a single-element transducer. The transmitted ultrasonic pulses that passed through the contrast agent-filled chamber were received by a second transducer or a hydrophone aligned with the first one. The radio frequency (RF) signals were acquired by fast echographic multiparameters multi-image novel apparatus (FEMMINA), which is an echographic platform able to acquire ultrasonic signals in a real-time modality. Three sets of ultrasonic signals were devised in order to evaluate subharmonic response of the contrast agent respect with sinusoidal burst signals used as reference pulses. A decreasing up to 30 dB in subharmonic response was detected for a Gaussian-shaped pulse; differences in subharmonic emission up to 21 dB were detected for a composite pulse (two-tone burst) for different acoustic pressures and concentrations. Results from this experimentation demonstrated that the transmitted pulse shape strongly affects subharmonic emission in spite of a second harmonic one. In particular, the smoothness of the initial portion of the shaped pulses can inhibit subharmonic generation from the contrast agents respect with a reference sinusoidal burst signal. It also was shown that subharmonic generation is influenced by the amplitude and the concentration of the contrast agent for each set of the shaped pulses. Subharmonic emissions that derive from a nonlinear mechanism involving nonlinear coupling among different oscillation modes are strongly affected by the shape of the ultrasonic driving pulse.

The figure has a shape, but the ground does not: evidence from a priming paradigm.

PubMed

Baylis, G C; Cale, E M

2001-06-01

In four experiments, the authors examined the extent to which the ground interpretation of an edge may receive a shape description. These experiments used the priming effect that shapes have on perceptual judgments on a subsequent trial. A robust reduction in error rates and reaction times was seen when the figural shape was the same as that on the previous trial. This repetition priming effect may be due to activation of the shape description of the figure that remained from the previous trial. In contrast, no priming by the shape of the ground was seen even when the contrast sign of the figure reversed between trials. Priming for figural shapes occurred at a relatively abstract level because it was robust across reversals of contrast and orientation. These data suggest that the figural interpretation of a shape receives a shape description but that the ground does not.

Active hydrothermal and non-active massive sulfide mound investigation using a new multiparameter chemical sensor

NASA Astrophysics Data System (ADS)

Han, C.; Wu, G.; Qin, H.; Wang, Z.

2012-12-01

Investigation of active hydrothermal mound as well as non-active massive sulfide mound are studied recently. However, there is still lack of in-situ detection method for the non-active massive sulfide mound. Even though Transient ElectroMagnetic (TEM) and Electric Self-potential (SP) methods are good, they both are labour, time and money cost work. We proposed a new multiparameter chemical sensor method to study the seafloor active hydrothermal mound as well as non-active massive sulfide mound. This sensor integrates Eh, S2- ions concentration and pH electrochemical electrodes together, and could found chemical change caused by the active hydrothermal vent, even weak chemical abnormalities by non-active massive sulfide hydrothermal mound which MARP and CTD sometimes cannot detect. In 2012, the 1st Leg of the Chinese 26th cruise, the multiparameter chemical sensor was carried out with the deepsea camera system over the Carlsberg Ridge in Indian Ocean by R/V DAYANGYIHAO. It was shown small Eh and S2- ions concentration abnormal around a site at Northwest Indian ridge. This site was also evidenced by the TV grab. In the 2nd Leg of the same cruise in June, this chemical sensor was carried out with TEM and SP survey system. The chemical abnormalities are matched very well with both TEM and SP survey results. The results show that the multiparameter chemical sensor method not only can detect active hydrothermal mound, but also can find the non-active massive sulfide hydrothermal mound.

Multiparameter models in the management of the development of territories, taking into account the influence of hydrometeorological factors

NASA Astrophysics Data System (ADS)

Istomin, E. P.; Popov, N. N.; Sokolov, A. G.; Fokicheva, A. A.

2018-01-01

The article considers the geoinformation management of the territory as a way to manage the organizational and technical systems and territories distributed in space. The article describes the main factors for the development and implementation of management decisions, requirements for the territorial management system and the structure of knowledge and data. Mathematical one-parameter and multiparameter models of risk assessment of management decisions applied to the natural and climatic potential of the development of the territory were considered.

Research on flow behaviors of the constituent grains in ferrite-martensite dual phase steels based on nanoindentation measurements

NASA Astrophysics Data System (ADS)

Gou, Rui-bin; Dan, Wen-jiao; Zhang, Wei-gang; Yu, Min

2017-07-01

To investigate the flow properties of constituent grains in ferrite-martensite dual phase steel, both the flow curve of individual grain and the flow behavior difference among different grains were investigated both using a classical dislocation-based model and nanoindentation technique. In the analysis of grain features, grain size, grain shape and martensite proximity around ferrite grain were parameterized by the diameter of area equivalent circular of the grain d, the grain shape coefficient λ and the martensite proximity coefficient p, respectively. Three grain features influenced significantly on the grain initial strength which increases when the grain size d decreases and when grain shape and martensite proximity coefficients enlarge. In describing the flow behavior of single grain, both single-parameter and multi-parameter empirical formulas of grain initial strength were proposed by defining three grain features as the evaluation parameters. It was found that the martensite proximity is an important determinant of ferrite initial strength, while the influence of grain size is minimal. The influence of individual grain was investigated using an improved flow model of overall stress on the overall flow curve of the steel. It was found that the predicted overall flow curve was in good agreement with the experimental one when the flow behaviors of all the constituent grains in the evaluated region were fully considered.

Simple Parametric Model for Airfoil Shape Description

NASA Astrophysics Data System (ADS)

Ziemkiewicz, David

2017-12-01

We show a simple, analytic equation describing a class of two-dimensional shapes well suited for representation of aircraft airfoil profiles. Our goal was to create a description characterized by a small number of parameters with easily understandable meaning, providing a tool to alter the shape with optimization procedures as well as manual tweaks by the designer. The generated shapes are well suited for numerical analysis with 2D flow solving software such as XFOIL.

Joint estimation of phase and phase diffusion for quantum metrology.

PubMed

Vidrighin, Mihai D; Donati, Gaia; Genoni, Marco G; Jin, Xian-Min; Kolthammer, W Steven; Kim, M S; Datta, Animesh; Barbieri, Marco; Walmsley, Ian A

2014-04-14

Phase estimation, at the heart of many quantum metrology and communication schemes, can be strongly affected by noise, whose amplitude may not be known, or might be subject to drift. Here we investigate the joint estimation of a phase shift and the amplitude of phase diffusion at the quantum limit. For several relevant instances, this multiparameter estimation problem can be effectively reshaped as a two-dimensional Hilbert space model, encompassing the description of an interferometer phase probed with relevant quantum states--split single-photons, coherent states or N00N states. For these cases, we obtain a trade-off bound on the statistical variances for the joint estimation of phase and phase diffusion, as well as optimum measurement schemes. We use this bound to quantify the effectiveness of an actual experimental set-up for joint parameter estimation for polarimetry. We conclude by discussing the form of the trade-off relations for more general states and measurements.

Source encoding in multi-parameter full waveform inversion

NASA Astrophysics Data System (ADS)

Matharu, Gian; Sacchi, Mauricio D.

2018-04-01

Source encoding techniques alleviate the computational burden of sequential-source full waveform inversion (FWI) by considering multiple sources simultaneously rather than independently. The reduced data volume requires fewer forward/adjoint simulations per non-linear iteration. Applications of source-encoded full waveform inversion (SEFWI) have thus far focused on monoparameter acoustic inversion. We extend SEFWI to the multi-parameter case with applications presented for elastic isotropic inversion. Estimating multiple parameters can be challenging as perturbations in different parameters can prompt similar responses in the data. We investigate the relationship between source encoding and parameter trade-off by examining the multi-parameter source-encoded Hessian. Probing of the Hessian demonstrates the convergence of the expected source-encoded Hessian, to that of conventional FWI. The convergence implies that the parameter trade-off in SEFWI is comparable to that observed in FWI. A series of synthetic inversions are conducted to establish the feasibility of source-encoded multi-parameter FWI. We demonstrate that SEFWI requires fewer overall simulations than FWI to achieve a target model error for a range of first-order optimization methods. An inversion for spatially inconsistent P - (α) and S-wave (β) velocity models, corroborates the expectation of comparable parameter trade-off in SEFWI and FWI. The final example demonstrates a shortcoming of SEFWI when confronted with time-windowing in data-driven inversion schemes. The limitation is a consequence of the implicit fixed-spread acquisition assumption in SEFWI. Alternative objective functions, namely the normalized cross-correlation and L1 waveform misfit, do not enable SEFWI to overcome this limitation.

Spectral collocation for multiparameter eigenvalue problems arising from separable boundary value problems

NASA Astrophysics Data System (ADS)

Plestenjak, Bor; Gheorghiu, Călin I.; Hochstenbach, Michiel E.

2015-10-01

In numerous science and engineering applications a partial differential equation has to be solved on some fairly regular domain that allows the use of the method of separation of variables. In several orthogonal coordinate systems separation of variables applied to the Helmholtz, Laplace, or Schrödinger equation leads to a multiparameter eigenvalue problem (MEP); important cases include Mathieu's system, Lamé's system, and a system of spheroidal wave functions. Although multiparameter approaches are exploited occasionally to solve such equations numerically, MEPs remain less well known, and the variety of available numerical methods is not wide. The classical approach of discretizing the equations using standard finite differences leads to algebraic MEPs with large matrices, which are difficult to solve efficiently. The aim of this paper is to change this perspective. We show that by combining spectral collocation methods and new efficient numerical methods for algebraic MEPs it is possible to solve such problems both very efficiently and accurately. We improve on several previous results available in the literature, and also present a MATLAB toolbox for solving a wide range of problems.

In-field experiment of electro-hydraulic tillage depth draft-position mixed control on tractor

NASA Astrophysics Data System (ADS)

Han, Jiangyi; Xia, Changgao; Shang, Gaogao; Gao, Xiang

2017-12-01

The soil condition and condition of the plow affect the tillage resistance and the maximum traction of tractor. In order to improve the adaptability of tractor tillage depth control, a multi-parameter control strategy is proposed that included tillage depth target, draft force aim and draft-position mixed ratio. In the strategy, the resistance coefficient was used to adjust the draft force target. Then, based on a JINMA1204 tractor, the electro-hydraulic hitch prototype is constructed that could set control parameters.. The fuzzy controller of draft-position mixed control is designed. After that, in-field experiments of position control was carried on, and the result of experiment shows the error of tillage depth was less than ±20mm. The experiment of draft-position control shown that the draft force and the tillage depth could be adjust by multi-parameter such as tillage depth, resistance coefficient and draft-position mixed coefficient. So that, the multi-parameter control strategy could improve the adaptability of tillage depth control in various soils and plow condition.

BioMEMS for multiparameter clinical monitoring

NASA Astrophysics Data System (ADS)

Moser, Isabella

2003-01-01

For diabetes patients glucose monitoring means an important improvement of their life quality and additionally it is a $3-billion-a-year business. Continuous glucose monitoring provides gapless glucose level control, an early warning of hypoglycemia, and is intended to control insulin pumps. An upgrading to multi-parameter monitoring would not only benefit patients with severe metabolism defects but also the metabolism of diabetes patient could be better controlled by monitoring an additional parameter like lactate. Multi-parameter monitoring devices are not commercially available, one of the complications in the integration of different biosensors using the same detecting molecule for all analytes is chemical cross talk between adjacent amperometric biosensors. Recently some integrated biosensors were published but either they were not mass producible or they were realized in an expensive silicon based technology. In addition to it most of them were not tested under monitoring conditions but their integration principles will be discussed. As an example a low cost multi- parameter microsystem and some applications of it in clinical diagnosis will be presented. Also an overlook of non-invasive methods and (minimal) invasive methods will be given with a focus on microdialysis.

Multi-parameter fiber optic sensors based on fiber random grating

NASA Astrophysics Data System (ADS)

Xu, Yanping; Zhang, Mingjiang; Lu, Ping; Mihailov, Stephen; Bao, Xiaoyi

2017-04-01

Two novel configurations of multi-parameter fiber-optic sensing systems based on the fiber random grating are reported. The fiber random grating is fabricated through femtosecond laser induced refractive index modification over a 10cm standard telecom single mode fiber. In one configuration, the reflective spectrum of the fiber random grating is directly detected and a wavelength-division spectral cross-correlation algorithm is adopted to extract the spectral shifts for simultaneous measurement of temperature, axial strain, and surrounding refractive index. In the other configuration, a random fiber ring laser is constructed by incorporating the random feedback from the random grating. Numerous polarization-dependent spectral filters are formed along the random grating and superimposed to provide multiple lasing lines with high signal-to-noise ratio up to 40dB, which enables a high-fidelity multi-parameter sensing scheme by monitoring the spectral shifts of the lasing lines. Without the need of phase mask for fabrication and with the high physical strength, the random grating based sensors are much simpler and more compact, which could be potentially an excellent alternative for liquid medical sample sensing in biomedical and biochemical applications.

Visual measurement of the evaporation process of a sessile droplet by dual-channel simultaneous phase-shifting interferometry.

PubMed

Sun, Peng; Zhong, Liyun; Luo, Chunshu; Niu, Wenhu; Lu, Xiaoxu

2015-07-16

To perform the visual measurement of the evaporation process of a sessile droplet, a dual-channel simultaneous phase-shifting interferometry (DCSPSI) method is proposed. Based on polarization components to simultaneously generate a pair of orthogonal interferograms with the phase shifts of π/2, the real-time phase of a dynamic process can be retrieved with two-step phase-shifting algorithm. Using this proposed DCSPSI system, the transient mass (TM) of the evaporation process of a sessile droplet with different initial mass were presented through measuring the real-time 3D shape of a droplet. Moreover, the mass flux density (MFD) of the evaporating droplet and its regional distribution were also calculated and analyzed. The experimental results show that the proposed DCSPSI will supply a visual, accurate, noncontact, nondestructive, global tool for the real-time multi-parameter measurement of the droplet evaporation.

Multiparameter Assessments To Determine the Effects of Sugars and Antimicrobials on a Polymicrobial Oral Biofilm

PubMed Central

Yang, Ying; Sreenivasan, Prem K.; Subramanyam, Ravi; Cummins, Diane

2006-01-01

Clinical studies indicate relationships between dental plaque, a naturally formed biofilm, and oral diseases. The crucial role of nonmicrobial biofilm constituents in maintaining biofilm structure and biofilm-specific attributes, such as resistance to shear and viscoelasticity, is increasingly recognized. Concurrent analyses of the diverse nonmicrobial biofilm components for multiparameter assessments formed the focus of this investigation. Comparable numbers of Actinomyces viscosus, Streptococcus sanguinis, Streptococcus mutans, Neisseria subflava, and Actinobacillus actinomycetemcomitans cells were seeded into multiple wells of 96-well polystyrene plates for biofilm formation. Quantitative fluorescence and confocal laser scanning microscopy (CLSM) examined the influences of dietary sugars, incubation conditions, ingredients in oral hygiene formulations, and antibiotics on biofilm components. Biofilm extracellular polymeric substances (EPS) were examined with an optimized mixture of fluorescent lectins, with biofilm proteins, lipids, and nucleic acids detected with specific fluorescent stains. Anaerobic incubation of biofilms resulted in significantly more biofilm EPS and extractable carbohydrates than those formed under aerobic conditions (P < 0.05). Sucrose significantly enhanced biofilm EPS in comparison to fructose, galactose, glucose, and lactose (P < 0.05). CLSM demonstrated thicker biofilms under sucrose-replete conditions, along with significant increases in biofilm EPS, proteins, lipids, and nucleic acids, than under conditions of sucrose deficiency (P < 0.05). Agents in oral hygiene formulations (chlorhexidine, ethanol, and sodium lauryl sulfate), a mucolytic agent (N-acetyl-l-cysteine), and antibiotics with different modes of action (amoxicillin, doxycycline, erythromycin, metronidazole, and vancomycin) inhibited biofilm components (P < 0.05). Multiparameter analysis indicated a dose-dependent inhibition of biofilm EPS and protein by chlorhexidine and sodium lauryl sulfate, along with distinctive inhibitory patterns for subinhibitory concentrations of antibiotics. Collectively, these results highlight multiparameter assessments as a broad platform for simultaneous assessment of diverse biofilm components. PMID:17021225

Single cell analysis using surface enhanced Raman scattering (SERS) tags

PubMed Central

Nolan, John P.; Duggan, Erika; Liu, Er; Condello, Danilo; Dave, Isha; Stoner, Samuel A.

2013-01-01

Fluorescence is a mainstay of bioanalytical methods, offering sensitive and quantitative reporting, often in multiplexed or multiparameter assays. Perhaps the best example of the latter is flow cytometry, where instruments equipped with multiple lasers and detectors allow measurement of 15 or more different fluorophores simultaneously, but increases beyond this number are limited by the relatively broad emission spectra. Surface enhanced Raman scattering (SERS) from metal nanoparticles can produce signal intensities that rival fluorescence, but with narrower spectral features that allow a greater degree of multiplexing. We are developing nanoparticle SERS tags as well as Raman flow cytometers for multiparameter single cell analysis of suspension or adherent cells. SERS tags are based on plasmonically active nanoparticles (gold nanorods) whose plasmon resonance can be tuned to give optimal SERS signals at a desired excitation wavelength. Raman resonant compounds are adsorbed on the nanoparticles to confer a unique spectral fingerprint on each SERS tag, which are then encapsulated in a polymer coating for conjugation to antibodies or other targeting molecules. Raman flow cytometry employs a high resolution spectral flow cytometer capable of measuring the complete SERS spectra, as well as conventional flow cytometry measurements, from thousands of individual cells per minute. Automated spectral unmixing algorithms extract the contributions of each SERS tag from each cell to generate high content, multiparameter single cell population data. SERS-based cytometry is a powerful complement to conventional fluorescence-based cytometry. The narrow spectral features of the SERS signal enables more distinct probes to be measured in a smaller region of the optical spectrum with a single laser and detector, allowing for higher levels of multiplexing and multiparameter analysis. PMID:22498143

Multi-parameter monitoring of electrical machines using integrated fibre Bragg gratings

NASA Astrophysics Data System (ADS)

Fabian, Matthias; Hind, David; Gerada, Chris; Sun, Tong; Grattan, Kenneth T. V.

2017-04-01

In this paper a sensor system for multi-parameter electrical machine condition monitoring is reported. The proposed FBG-based system allows for the simultaneous monitoring of machine vibration, rotor speed and position, torque, spinning direction, temperature distribution along the stator windings and on the rotor surface as well as the stator wave frequency. This all-optical sensing solution reduces the component count of conventional sensor systems, i.e., all 48 sensing elements are contained within the machine operated by a single sensing interrogation unit. In this work, the sensing system has been successfully integrated into and tested on a permanent magnet motor prototype.

Accidental degeneracies in nonlinear quantum deformed systems

NASA Astrophysics Data System (ADS)

Aleixo, A. N. F.; Balantekin, A. B.

2011-09-01

We construct a multi-parameter nonlinear deformed algebra for quantum confined systems that includes many other deformed models as particular cases. We demonstrate that such systems exhibit the property of accidental pairwise energy level degeneracies. We also study, as a special case of our multi-parameter deformation formalism, the extension of the Tamm-Dancoff cutoff deformed oscillator and the occurrence of accidental pairwise degeneracy in the energy levels of the deformed system. As an application, we discuss the case of a trigonometric Rosen-Morse potential, which is successfully used in models for quantum confined systems, ranging from electrons in quantum dots to quarks in hadrons.

Hydrometeor discrimination in melting layer using multiparameter airborne radar measurement

NASA Technical Reports Server (NTRS)

Kumagai, H.; Meneghini, R.; Kozu, T.

1992-01-01

Results from a multiparameter airborne radar/radiometer experiment (the Typhoon experiment) are presented. The experiment was conducted in the western Pacific with the NASA DC-8 aircraft, in which a dual-wavelength at X-band and Ka-band and dual-polarization at X-band radar was installed. The signatures of dBZ(X), dBZ(Ka), LDR (linear depolarization ratio) at X-band and DZ=dBZ(X)-dBZ(Ka) are discussed for the data obtained in the penetration of the typhoon Flo. With emphasis on discrimination of hydrometeor particles, some statistical features of the brightband in stratiform rain are discussed.

Probabilistic teleportation via multi-parameter measurements and partially entangled states

NASA Astrophysics Data System (ADS)

Wei, Jiahua; Shi, Lei; Han, Chen; Xu, Zhiyan; Zhu, Yu; Wang, Gang; Wu, Hao

2018-04-01

In this paper, a novel scheme for probabilistic teleportation is presented with multi-parameter measurements via a non-maximally entangled state. This is in contrast to the fact that the measurement kinds for quantum teleportation are usually particular in most previous schemes. The detail implementation producers for our proposal are given by using of appropriate local unitary operations. Moreover, the total success probability and classical information of this proposal are calculated. It is demonstrated that the success probability and classical cost would be changed with the multi-measurement parameters and the entanglement factor of quantum channel. Our scheme could enlarge the research range of probabilistic teleportation.

Simultaneous Multiparameter Cellular Energy Metabolism Profiling of Small Populations of Cells.

PubMed

Kelbauskas, Laimonas; Ashili, Shashaanka P; Lee, Kristen B; Zhu, Haixin; Tian, Yanqing; Meldrum, Deirdre R

2018-03-12

Functional and genomic heterogeneity of individual cells are central players in a broad spectrum of normal and disease states. Our knowledge about the role of cellular heterogeneity in tissue and organism function remains limited due to analytical challenges one encounters when performing single cell studies in the context of cell-cell interactions. Information based on bulk samples represents ensemble averages over populations of cells, while data generated from isolated single cells do not account for intercellular interactions. We describe a new technology and demonstrate two important advantages over existing technologies: first, it enables multiparameter energy metabolism profiling of small cell populations (<100 cells)-a sample size that is at least an order of magnitude smaller than other, commercially available technologies; second, it can perform simultaneous real-time measurements of oxygen consumption rate (OCR), extracellular acidification rate (ECAR), and mitochondrial membrane potential (MMP)-a capability not offered by any other commercially available technology. Our results revealed substantial diversity in response kinetics of the three analytes in dysplastic human epithelial esophageal cells and suggest the existence of varying cellular energy metabolism profiles and their kinetics among small populations of cells. The technology represents a powerful analytical tool for multiparameter studies of cellular function.

Multicolor Super-Resolution Fluorescence Imaging via Multi-Parameter Fluorophore Detection

PubMed Central

Bates, Mark; Dempsey, Graham T; Chen, Kok Hao; Zhuang, Xiaowei

2012-01-01

Understanding the complexity of the cellular environment will benefit from the ability to unambiguously resolve multiple cellular components, simultaneously and with nanometer-scale spatial resolution. Multicolor super-resolution fluorescence microscopy techniques have been developed to achieve this goal, yet challenges remain in terms of the number of targets that can be simultaneously imaged and the crosstalk between color channels. Herein, we demonstrate multicolor stochastic optical reconstruction microscopy (STORM) based on a multi-parameter detection strategy, which uses both the fluorescence activation wavelength and the emission color to discriminate between photo-activatable fluorescent probes. First, we obtained two-color super-resolution images using the near-infrared cyanine dye Alexa 750 in conjunction with a red cyanine dye Alexa 647, and quantified color crosstalk levels and image registration accuracy. Combinatorial pairing of these two switchable dyes with fluorophores which enhance photo-activation enabled multi-parameter detection of six different probes. Using this approach, we obtained six-color super-resolution fluorescence images of a model sample. The combination of multiple fluorescence detection parameters for improved fluorophore discrimination promises to substantially enhance our ability to visualize multiple cellular targets with sub-diffraction-limit resolution. PMID:22213647

In-Pile Instrumentation Multi- Parameter System Utilizing Photonic Fibers and Nanovision

DOE Office of Scientific and Technical Information (OSTI.GOV)

Burgett, Eric

2015-10-13

An advanced in-pile multi-parameter reactor monitoring system is being proposed in this funding opportunity. The proposed effort brings cutting edge, high fidelity optical measurement systems into the reactor environment in an unprecedented fashion, including in-core, in-cladding and in-fuel pellet itself. Unlike instrumented leads, the proposed system provides a unique solution to a multi-parameter monitoring need in core while being minimally intrusive in the reactor core. Detector designs proposed herein can monitor fuel compression and expansion in both the radial and axial dimensions as well as monitor linear power profiles and fission rates during the operation of the reactor. In additionmore » to pressure, stress, strain, compression, neutron flux, neutron spectra, and temperature can be observed inside the fuel bundle and fuel rod using the proposed system. The proposed research aims at developing radiation-hard, harsh-environment multi-parameter systems for insertion into the reactor environment. The proposed research holds the potential to drastically increase the fidelity and precision of in-core instrumentation with little or no impact in the neutron economy in the reactor environment while providing a measurement system capable of operation for entire operating cycles.« less

Partial-Wave Representations of Laser Beams for Use in Light-Scattering Calculations

NASA Technical Reports Server (NTRS)

Gouesbet, Gerard; Lock, James A.; Grehan, Gerard

1995-01-01

In the framework of generalized Lorenz-Mie theory, laser beams are described by sets of beam-shape coefficients. The modified localized approximation to evaluate these coefficients for a focused Gaussian beam is presented. A new description of Gaussian beams, called standard beams, is introduced. A comparison is made between the values of the beam-shape coefficients in the framework of the localized approximation and the beam-shape coefficients of standard beams. This comparison leads to new insights concerning the electromagnetic description of laser beams. The relevance of our discussion is enhanced by a demonstration that the localized approximation provides a very satisfactory description of top-hat beams as well.

Multi-parameter optimization of piezoelectric actuators for multi-mode active vibration control of cylindrical shells

NASA Astrophysics Data System (ADS)

Hu, K. M.; Li, Hua

2018-07-01

A novel technique for the multi-parameter optimization of distributed piezoelectric actuators is presented in this paper. The proposed method is designed to improve the performance of multi-mode vibration control in cylindrical shells. The optimization parameters of actuator patch configuration include position, size, and tilt angle. The modal control force of tilted orthotropic piezoelectric actuators is derived and the multi-parameter cylindrical shell optimization model is established. The linear quadratic energy index is employed as the optimization criterion. A geometric constraint is proposed to prevent overlap between tilted actuators, which is plugged into a genetic algorithm to search the optimal configuration parameters. A simply-supported closed cylindrical shell with two actuators serves as a case study. The vibration control efficiencies of various parameter sets are evaluated via frequency response and transient response simulations. The results show that the linear quadratic energy indexes of position and size optimization decreased by 14.0% compared to position optimization; those of position and tilt angle optimization decreased by 16.8%; and those of position, size, and tilt angle optimization decreased by 25.9%. It indicates that, adding configuration optimization parameters is an efficient approach to improving the vibration control performance of piezoelectric actuators on shells.

Shape transformation of viral capsids and HIV

NASA Astrophysics Data System (ADS)

Nguyen, Toan

2005-03-01

We present a continuum description of the shape transformation of viral capsids. The cone-like HIV virus is shown to be an thermodynamic stable shape, intermediate between icosahedral and sphero-cylinder capsid shapes. A generalized Caspar-Klug classification is introduced to describe spherical, conical and cylinderical shapes of virus.

Guidelines for improving the reproducibility of quantitative multiparameter immunofluorescence measurements by laser scanning cytometry on fixed cell suspensions from human solid tumors.

PubMed

Shackney, Stanley; Emlet, David R; Pollice, Agnese; Smith, Charles; Brown, Kathryn; Kociban, Deborah

2006-01-01

Laser scanning Cytometry (LSC) is a versatile technology that makes it possible to perform multiple measurements on individual cells and correlate them cell by cell with other cellular features. It would be highly desirable to be able to perform reproducible, quantitative, correlated cell-based immunofluorescence studies on individual cells from human solid tumors. However, such studies can be challenging because of the presence of large numbers of cell aggregates and other confounding factors. Techniques have been developed to deal with cell aggregates in data sets collected by LSC. Experience has also been gained in addressing other key technical and methodological issues that can affect the reproducibility of such cell-based immunofluorescence measurements. We describe practical aspects of cell sample collection, cell fixation and staining, protocols for performing multiparameter immunofluorescence measurements by LSC, use of controls and reference samples, and approaches to data analysis that we have found useful in improving the accuracy and reproducibility of LSC data obtained in human tumor samples. We provide examples of the potential advantages of LSC in examining quantitative aspects of cell-based analysis. Improvements in the quality of cell-based multiparameter immunofluorescence measurements make it possible to extract useful information from relatively small numbers of cells. This, in turn, permits the performance of multiple multicolor panels on each tumor sample. With links among the different panels that are provided by overlapping measurements, it is possible to develop increasingly more extensive profiles of intracellular expression of multiple proteins in clinical samples of human solid tumors. Examples of such linked panels of measurements are provided. Advances in methodology can improve cell-based multiparameter immunofluorescence measurements on cell suspensions from human solid tumors by LSC for use in prognostic and predictive clinical applications. Copyright (c) 2005 Wiley-Liss, Inc.

Interparameter trade-off quantification and reduction in isotropic-elastic full-waveform inversion: synthetic experiments and Hussar land data set application

NASA Astrophysics Data System (ADS)

Pan, Wenyong; Geng, Yu; Innanen, Kristopher A.

2018-05-01

The problem of inverting for multiple physical parameters in the subsurface using seismic full-waveform inversion (FWI) is complicated by interparameter trade-off arising from inherent ambiguities between different physical parameters. Parameter resolution is often characterized using scattering radiation patterns, but these neglect some important aspects of interparameter trade-off. More general analysis and mitigation of interparameter trade-off in isotropic-elastic FWI is possible through judiciously chosen multiparameter Hessian matrix-vector products. We show that products of multiparameter Hessian off-diagonal blocks with model perturbation vectors, referred to as interparameter contamination kernels, are central to the approach. We apply the multiparameter Hessian to various vectors designed to provide information regarding the strengths and characteristics of interparameter contamination, both locally and within the whole volume. With numerical experiments, we observe that S-wave velocity perturbations introduce strong contaminations into density and phase-reversed contaminations into P-wave velocity, but themselves experience only limited contaminations from other parameters. Based on these findings, we introduce a novel strategy to mitigate the influence of interparameter trade-off with approximate contamination kernels. Furthermore, we recommend that the local spatial and interparameter trade-off of the inverted models be quantified using extended multiparameter point spread functions (EMPSFs) obtained with pre-conditioned conjugate-gradient algorithm. Compared to traditional point spread functions, the EMPSFs appear to provide more accurate measurements for resolution analysis, by de-blurring the estimations, scaling magnitudes and mitigating interparameter contamination. Approximate eigenvalue volumes constructed with stochastic probing approach are proposed to evaluate the resolution of the inverted models within the whole model. With a synthetic Marmousi model example and a land seismic field data set from Hussar, Alberta, Canada, we confirm that the new inversion strategy suppresses the interparameter contamination effectively and provides more reliable density estimations in isotropic-elastic FWI as compared to standard simultaneous inversion approach.

An all fiber-optic multi-parameter structure health monitoring system

DOE PAGES

Hu, Chennan; Yu, Zhihao; Wang, Anbo

2016-08-24

In this article, we present an all fiber-optics based multi-parameter structure health monitoring system, which is able to monitor strain, temperature, crack and thickness of metal structures. This system is composed of two optical fibers, one for laser-acoustic excitation and the other for acoustic detection. A nano-second 1064 nm pulse laser was used for acoustic excitation and a 2 mm fiber Bragg grating was used to detect the acoustic vibration. The feasibility of this system was demonstrated on an aluminum test piece by the monitoring of the temperature, strain and thickness changes, as well as the appearance of an artificialmore » crack. The multiplexing capability of this system was also preliminarily demonstrated.« less

An all fiber-optic multi-parameter structure health monitoring system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hu, Chennan; Yu, Zhihao; Wang, Anbo

In this article, we present an all fiber-optics based multi-parameter structure health monitoring system, which is able to monitor strain, temperature, crack and thickness of metal structures. This system is composed of two optical fibers, one for laser-acoustic excitation and the other for acoustic detection. A nano-second 1064 nm pulse laser was used for acoustic excitation and a 2 mm fiber Bragg grating was used to detect the acoustic vibration. The feasibility of this system was demonstrated on an aluminum test piece by the monitoring of the temperature, strain and thickness changes, as well as the appearance of an artificialmore » crack. The multiplexing capability of this system was also preliminarily demonstrated.« less

Flow-cytometric identification of vinegars using a multi-parameter analysis optical detection module

NASA Astrophysics Data System (ADS)

Verschooten, T.; Ottevaere, H.; Vervaeke, M.; Van Erps, J.; Callewaert, M.; De Malsche, W.; Thienpont, H.

2015-09-01

We show a proof-of-concept demonstration of a multi-parameter analysis low-cost optical detection system for the flowcytometric identification of vinegars. This multi-parameter analysis system can simultaneously measure laser induced fluorescence, absorption and scattering excited by two time-multiplexed lasers of different wavelengths. To our knowledge no other polymer optofluidic chip based system offers more simultaneous measurements. The design of the optofluidic channels is aimed at countering the effects that viscous fingering, air bubbles, and emulsion samples can have on the correct operation of such a detection system. Unpredictable variations in viscosity and refractive index of the channel content can be turned into a source of information. The sample is excited by two laser diodes that are driven by custom made low-cost laser drivers. The optofluidic chip is built to be robust and easy to handle and is reproducible using hot embossing. We show a custom optomechanical holder for the optofluidic chip that ensures correct alignment and automatic connection to the external fluidic system. We show an experiment in which 92 samples of vinegar are measured. We are able to identify 9 different kinds of vinegar with an accuracy of 94%. Thus we show an alternative approach to the classic optical spectroscopy solution at a lowered. Furthermore, we have shown the possibility of predicting the viscosity and turbidity of vinegars with a goodness-of-fit R2 over 0.947.

A molecular informatics view on best practice in multi-parameter compound optimization.

PubMed

Lusher, Scott J; McGuire, Ross; Azevedo, Rita; Boiten, Jan-Willem; van Schaik, Rene C; de Vlieg, Jacob

2011-07-01

The difference between biologically active molecules and drugs is that the latter balance an array of related and unrelated properties required for administration to patients. Inevitability, during optimization, some of these multiple factors will conflict. Although informatics has a crucial role in addressing the challenges of modern compound optimization, it is arguably still undervalued and underutilized. We present here some of the basic requirements of multi-parameter drug design, the crucial role of informatics and examples of favorable practice. The most crucial of these best practices are the need for informaticians to align their technologies and insights directly to discovery projects and for all scientists in drug discovery to become more proficient in the use of in silico methods. Copyright © 2011 Elsevier Ltd. All rights reserved.

[The design and experiment of multi-parameter water quality monitoring microsystem based on MOEMS microspectrometer].

PubMed

Wei, Kang-Lin; Wen, Zhi-Yu; Guo, Jian; Chen, Song-Bo

2012-07-01

Aiming at the monitoring and protecting of water resource environment, a multi-parameter water quality monitoring microsystem based on microspectrometer was put forward in the present paper. The microsystem is mainly composed of MOEMS microspectrometer, flow paths system and embedded measuring & controlling system. It has the functions of self-injecting samples and detection regents, automatic constant temperature, self -stirring, self- cleaning and samples' spectrum detection. The principle prototype machine of the microsystem was developed, and its structure principle was introduced in the paper. Through experiment research, it was proved that the principle prototype machine can rapidly detect quite a few water quality parameters and can meet the demands of on-line water quality monitoring, moreover, the principle prototype machine has strong function expansibility.

Reconfigurable Multiparameter Biosignal Acquisition SoC for Low Power Wearable Platform

PubMed Central

Kim, Jongpal; Ko, Hyoungho

2016-01-01

A low power and low noise reconfigurable analog front-end (AFE) system on a chip (SoC) for biosignal acquisition is presented. The presented AFE can be reconfigured for use in electropotential, bioimpedance, electrochemical, and photoelectrical modes. The advanced healthcare services based on multiparameter physiological biosignals can be easily implemented with these multimodal and highly reconfigurable features of the proposed system. The reconfigurable gain and input referred noise of the core instrumentation amplifier block are 25 dB to 52 dB, and 1 μVRMS, respectively. The power consumption of the analog blocks in one readout channel is less than 52 μW. The reconfigurable capability among various modes of applications including electrocardiogram, blood glucose concentration, respiration, and photoplethysmography are shown experimentally. PMID:27898004

Dual-optical-response photonic crystal fibre interferometer for multi-parameter sensing

NASA Astrophysics Data System (ADS)

Villatoro, Joel; Minkovich, Vladimir P.; Zubia, Joseba

2014-05-01

An all-fiber mode interferometer consisting of a short segment of photonic crystal fiber (PCF) fusion spliced to standard single mode optical fiber and pressed on localized regions is proposed for multi-parameter sensing. In our configuration, the physical parameter being sensed changes the fringe contrast (or visibility) of the interference pattern and also causes a shift to the same. To achieve this dual effect the device is pressed on localized regions over a few millimeters. In this manner we introduce losses and effective refractive index changes to the interference modes, hence visibility and shift to the interference pattern. Our interferometer is suitable for monitoring diverse physical parameters such as weight, force, pressure, load, etc. The advantage is that no temperature or power fluctuations compensation is required.

n-D shape/texture optimal synthetic description and modeling by GEOGINE

NASA Astrophysics Data System (ADS)

Fiorini, Rodolfo A.; Dacquino, Gianfranco F.

2004-12-01

GEOGINE(GEOmetrical enGINE), a state-of-the-art OMG (Ontological Model Generator) based on n-D Tensor Invariants for multidimensional shape/texture optimal synthetic description and learning, is presented. Usually elementary geometric shape robust characterization, subjected to geometric transformation, on a rigorous mathematical level is a key problem in many computer applications in different interest areas. The past four decades have seen solutions almost based on the use of n-Dimensional Moment and Fourier descriptor invariants. The present paper introduces a new approach for automatic model generation based on n -Dimensional Tensor Invariants as formal dictionary. An ontological model is the kernel used for specifying ontologies so that how close an ontology can be from the real world depends on the possibilities offered by the ontological model. By this approach even chromatic information content can be easily and reliably decoupled from target geometric information and computed into robus colour shape parameter attributes. Main GEOGINEoperational advantages over previous approaches are: 1) Automated Model Generation, 2) Invariant Minimal Complete Set for computational efficiency, 3) Arbitrary Model Precision for robust object description.

Analysis of the shapes of hemocytes of Callista brevisiphonata in vitro (Bivalvia, Veneridae).

PubMed

Karetin, Yu A; Pushchin, I I

2015-08-01

Fractal formalism in conjunction with linear methods of image analysis is suitable for the comparative analysis of such "irregular" shapes (from the point of view of classical Euclidean geometry) as flattened amoeboid cells of invertebrates in vitro. Cell morphology of in vitro spreading hemocytes from the bivalve mollusc Callista brevisiphonata was analyzed using correlation, factor and cluster analysis. Four significantly different cell types were identified on the basis of 36 linear and nonlinear parameters. The analysis confirmed the adequacy of the selected methodology for numerical description of the shape and the adequacy of classification of nonlinear shapes of spread hemocytes belonging to the same species. Investigation has practical significance for the description of the morphology of cultured cells, since cell shape is a result of summation of a number of extracellular and intracellular factors. © 2015 International Society for Advancement of Cytometry.

Airborne gamma-ray spectrometer and magnetometer survey: Weed quadrangle, California. Final report

DOE Office of Scientific and Technical Information (OSTI.GOV)

Not Available

1981-05-01

Volume II contains the flight path, radiometric multi-parameter stacked profiles, magnetic and ancillary parameter stacked profiles, histograms, and anomaly maps for the Weed Quadrangle in California.

The NWRA Classification Infrastructure: description and extension to the Discriminant Analysis Flare Forecasting System (DAFFS)

NASA Astrophysics Data System (ADS)

Leka, K. D.; Barnes, Graham; Wagner, Eric

2018-04-01

A classification infrastructure built upon Discriminant Analysis (DA) has been developed at NorthWest Research Associates for examining the statistical differences between samples of two known populations. Originating to examine the physical differences between flare-quiet and flare-imminent solar active regions, we describe herein some details of the infrastructure including: parametrization of large datasets, schemes for handling "null" and "bad" data in multi-parameter analysis, application of non-parametric multi-dimensional DA, an extension through Bayes' theorem to probabilistic classification, and methods invoked for evaluating classifier success. The classifier infrastructure is applicable to a wide range of scientific questions in solar physics. We demonstrate its application to the question of distinguishing flare-imminent from flare-quiet solar active regions, updating results from the original publications that were based on different data and much smaller sample sizes. Finally, as a demonstration of "Research to Operations" efforts in the space-weather forecasting context, we present the Discriminant Analysis Flare Forecasting System (DAFFS), a near-real-time operationally-running solar flare forecasting tool that was developed from the research-directed infrastructure.

Shape coexistence, shape evolution and Gamow-Teller {beta}-decay of neutron-rich A Asymptotically-Equal-To 100 nuclei

DOE Office of Scientific and Technical Information (OSTI.GOV)

Petrovici, A.; Schmid, K. W.; Faessler, A.

The structure of neutron-rich nuclei in the A Asymptotically-Equal-To 100 mass region relevant for the astrophysical r process manifests drastic changes in some isotopic chains and often sudden variations of particular nuclear properties have been identified. For a realistic description of the evolution in structure with increasing energy, spin, and isospin determined by shape coexistence and mixing beyond-mean-field approaches are required. Our recent studies represent an attempt to the self-consistent description of the shape coexistence phenomena in neutron-rich A Asymptotically-Equal-To 100 nuclei within the complex Excited Vampir variational model with symmetry projection before variation using a realistic effective interaction basedmore » on the Bonn A potential in a large model space. Results concerning the triple shape coexistence and the shape evolution in the N=58 Sr and Zr isotopes, the shape evolution in a chain of Zr nuclei, as well as the Gamow-Teller {beta}-decay properties of neutron-rich Zr and Tc nuclei are presented.« less

Crash Padding Research : Volume II. Constitutive Equation Models.

DOT National Transportation Integrated Search

1986-08-01

Several simplified one-dimensional constitutive equations for viscoelastic materials are reviewed and found to be inadequate for representing the impact-response performance of strongly nonlinear materials. Two multi-parameter empirical models are de...

Fiber Optic Sensor Embedment Study for Multi-Parameter Strain Sensing

PubMed Central

Drissi-Habti, Monssef; Raman, Venkadesh; Khadour, Aghiad; Timorian, Safiullah

2017-01-01

The fiber optic sensors (FOSs) are commonly used for large-scale structure monitoring systems for their small size, noise free and low electrical risk characteristics. Embedded fiber optic sensors (FOSs) lead to micro-damage in composite structures. This damage generation threshold is based on the coating material of the FOSs and their diameter. In addition, embedded FOSs are aligned parallel to reinforcement fibers to avoid micro-damage creation. This linear positioning of distributed FOS fails to provide all strain parameters. We suggest novel sinusoidal sensor positioning to overcome this issue. This method tends to provide multi-parameter strains in a large surface area. The effectiveness of sinusoidal FOS positioning over linear FOS positioning is studied under both numerical and experimental methods. This study proves the advantages of the sinusoidal positioning method for FOS in composite material’s bonding. PMID:28333117

A Multiparameter Thermal Conductivity Equation for 1,1-Difluoroethane (R152a) with an Optimized Functional Form

NASA Astrophysics Data System (ADS)

Scalabrin, G.; Marchi, P.; Finezzo, F.

2006-11-01

The application of an optimization technique to the available experimental data has led to the development of a new multiparameter equation λ = λ ( T,ρ ) for the representation of the thermal conductivity of 1,1-difluoroethane (R152a). The region of validity of the proposed equation covers the temperature range from 220 to 460 K and pressures up to 55 MPa, including the near-critical region. The average absolute deviation of the equation with respect to the selected 939 primary data points is 1.32%. The proposed equation represents therefore a significant improvement with respect to the literature conventional equation. The density value required by the equation is calculated at the chosen temperature and pressure conditions using a high accuracy equation of state for the fluid.

[Multiparameter magnetic resonance imaging in the diagnosis of cancer of the cervix uteri].

PubMed

Tarachkova, E V; Strel'tsova, O N; Panov, V O; Bazaeva, I Ya; Tyurin, I E

2015-01-01

Cancer of the cervix uteri (CCU) ranks third in the incidence of malignancies in women. The choice of CCU treatment mainly depends on the extent of the tumor process, i.e., the stage of the disease. Determining the stage of CCU is based on the clinical classification of the International Federation of Gynecology and Obstetrics (FIGO) (2009) and has a number of substantial limitations in evaluating parametrial invasion, tumor spread to the pelvic wall, and involvement of regional lymph nodes and in determining the true tumor sizes. Magnetic resonance imaging (MRI) is now the method of choice in staging invasive CCU. Multiparameter MRI will be able to enhance the efficiency of diagnosing microinvasive CCU as well (FIGO 2009), to plan surgical and/or chemoradiation treatment, to evaluate its efficiency, and to diagnose locally recurrent CCU.

High speed demodulation systems for fiber optic grating sensors

NASA Technical Reports Server (NTRS)

Udd, Eric (Inventor); Weisshaar, Andreas (Inventor)

2002-01-01

Fiber optic grating sensor demodulation systems are described that offer high speed and multiplexing options for both single and multiple parameter fiber optic grating sensors. To attain very high speeds for single parameter fiber grating sensors ratio techniques are used that allow a series of sensors to be placed in a single fiber while retaining high speed capability. These methods can be extended to multiparameter fiber grating sensors. Optimization of speeds can be obtained by minimizing the number of spectral peaks that must be processed and it is shown that two or three spectral peak measurements may in specific multiparameter applications offer comparable or better performance than processing four spectral peaks. Combining the ratio methods with minimization of peak measurements allows very high speed measurement of such important environmental effects as transverse strain and pressure.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Burgett, Eric; Al-Sheikhly, Mohamad; Summers, Christopher

An advanced in-pile multi-parameter reactor monitoring system is being proposed in this funding opportunity. The proposed effort brings cutting edge, high-fidelity optical measurement systems into the reactor environment in an unprecedented fashion, including in-core, in-cladding and in-fuel pellet itself. Unlike instrumented leads, the proposed system provides a unique solution to a multi-parameter monitoring need in core while being minimally intrusive in the reactor core. Detector designs proposed herein can monitor fuel compression and expansion in both the radial and axial dimensions as well as monitor linear power profiles and fission rates during the operation of the reactor. In addition tomore » pressure, stress, strain, compression, neutron flux, neutron spectra, and temperature can be observed inside the fuel bundle and fuel rod using the proposed system. The proposed research aims at developing radiation-hard, harsh-environment multi-parameter systems for insertion into the reactor environment. The proposed research holds the potential to drastically increase the fidelity and precision of in-core instrumentation with little or no impact in the neutron economy in the reactor environment while providing a measurement system capable of operation for entire operating cycles. Significant work has been done over the last few years on the use of nanoparticle-based scintillators. Through the use of metamaterials, the PIs aim to develop planar neutron detectors and large-volume neutron detectors. These detectors will have high efficiencies for neutron detection and will have a high gamma discrimination capability.« less

Parametrization study of the land multiparameter VTI elastic waveform inversion

NASA Astrophysics Data System (ADS)

He, W.; Plessix, R.-É.; Singh, S.

2018-06-01

Multiparameter inversion of seismic data remains challenging due to the trade-off between the different elastic parameters and the non-uniqueness of the solution. The sensitivity of the seismic data to a given subsurface elastic parameter depends on the source and receiver ray/wave path orientations at the subsurface point. In a high-frequency approximation, this is commonly analysed through the study of the radiation patterns that indicate the sensitivity of each parameter versus the incoming (from the source) and outgoing (to the receiver) angles. In practice, this means that the inversion result becomes sensitive to the choice of parametrization, notably because the null-space of the inversion depends on this choice. We can use a least-overlapping parametrization that minimizes the overlaps between the radiation patterns, in this case each parameter is only sensitive in a restricted angle domain, or an overlapping parametrization that contains a parameter sensitive to all angles, in this case overlaps between the radiation parameters occur. Considering a multiparameter inversion in an elastic vertically transverse isotropic medium and a complex land geological setting, we show that the inversion with the least-overlapping parametrization gives less satisfactory results than with the overlapping parametrization. The difficulties come from the complex wave paths that make difficult to predict the areas of sensitivity of each parameter. This shows that the parametrization choice should not only be based on the radiation pattern analysis but also on the angular coverage at each subsurface point that depends on geology and the acquisition layout.

Integrated waveguide and nanostructured sensor platform for surface-enhanced Raman spectroscopy

NASA Astrophysics Data System (ADS)

Pearce, Stuart J.; Pollard, Michael E.; Oo, SweZin; Chen, Ruiqi; Kalsi, Sumit; Charlton, Martin D. B.

2014-01-01

Limitations of current sensors include large dimensions, sometimes limited sensitivity and inherent single-parameter measurement capability. Surface-enhanced Raman spectroscopy can be utilized for environment and pharmaceutical applications with the intensity of the Raman scattering enhanced by a factor of 10. By fabricating and characterizing an integrated optical waveguide beneath a nanostructured precious metal coated surface a new surface-enhanced Raman spectroscopy sensing arrangement can be achieved. Nanostructured sensors can provide both multiparameter and high-resolution sensing. Using the slab waveguide core to interrogate the nanostructures at the base allows for the emission to reach discrete sensing areas effectively and should provide ideal parameters for maximum Raman interactions. Thin slab waveguide films of silicon oxynitride were etched and gold coated to create localized nanostructured sensing areas of various pitch, diameter, and shape. These were interrogated using a Ti:Sapphire laser tuned to 785-nm end coupled into the slab waveguide. The nanostructured sensors vertically projected a Raman signal, which was used to actively detect a thin layer of benzyl mercaptan attached to the sensors.

Young Children's Concepts of Shape.

ERIC Educational Resources Information Center

Clements, Douglas H.; Swaminathan, Sudha; Hannibal, Mary Anne Zeitler; Sarama, Julie

1999-01-01

Investigates, by conducting individual clinical interviews of 97 children ages 3 to 6, the criteria preschool children use to distinguish members of a class of shapes from other figures, emphasizing identification and descriptions of shapes and reasons for these identifications. Concludes that young children initially form schemas on the basis of…

A corrosion monitoring system for existing reinforced concrete structures.

DOT National Transportation Integrated Search

2015-05-01

This study evaluated a multi-parameter corrosion monitoring system for existing reinforced concrete structures in chloride-laden service environments. The system was fabricated based on a prototype concrete corrosion measurement system that : had bee...

A New Shape Description Method Using Angular Radial Transform

NASA Astrophysics Data System (ADS)

Lee, Jong-Min; Kim, Whoi-Yul

Shape is one of the primary low-level image features in content-based image retrieval. In this paper we propose a new shape description method that consists of a rotationally invariant angular radial transform descriptor (IARTD). The IARTD is a feature vector that combines the magnitude and aligned phases of the angular radial transform (ART) coefficients. A phase correction scheme is employed to produce the aligned phase so that the IARTD is invariant to rotation. The distance between two IARTDs is defined by combining differences in the magnitudes and aligned phases. In an experiment using the MPEG-7 shape dataset, the proposed method outperforms existing methods; the average BEP of the proposed method is 57.69%, while the average BEPs of the invariant Zernike moments descriptor and the traditional ART are 41.64% and 36.51%, respectively.

Closed Forms for 4-Parameter Families of Integrals

ERIC Educational Resources Information Center

Dana-Picard, Thierry; Zeitoun, David G.

2009-01-01

We compute closed forms for two multiparameter families of definite integrals, thus obtaining combinatorial formulas. As a consequence, a surprising formula is derived between a definite integral and an improper integral for the same parametric function.

Multiparameter magnetic inspection system with magnetic field control and plural magnetic transducers

DOEpatents

Jiles, D.C.

1991-04-16

A multiparameter magnetic inspection system is disclosed for providing an efficient and economical way to derive a plurality of independent measurements regarding magnetic properties of the magnetic material under investigation. The plurality of transducers for a plurality of different types of measurements operatively connected to the specimen. The transducers are in turn connected to analytical circuits for converting transducer signals to meaningful measurement signals of the magnetic properties of the specimen. The measurement signals are processed and can be simultaneously communicated to a control component. The measurement signals can also be selectively plotted against one another. The control component operates the functioning of the analytical circuits and operates and controls components to impose magnetic fields of desired characteristics upon the specimen. The system therefore allows contemporaneous or simultaneous derivation of the plurality of different independent magnetic properties of the material which can then be processed to derive characteristics of the material. 1 figure.

Reconstruction of ECG signals in presence of corruption.

PubMed

Ganeshapillai, Gartheeban; Liu, Jessica F; Guttag, John

2011-01-01

We present an approach to identifying and reconstructing corrupted regions in a multi-parameter physiological signal. The method, which uses information in correlated signals, is specifically designed to preserve clinically significant aspects of the signals. We use template matching to jointly segment the multi-parameter signal, morphological dissimilarity to estimate the quality of the signal segment, similarity search using features on a database of templates to find the closest match, and time-warping to reconstruct the corrupted segment with the matching template. In experiments carried out on the MIT-BIH Arrhythmia Database, a two-parameter database with many clinically significant arrhythmias, our method improved the classification accuracy of the beat type by more than 7 times on a signal corrupted with white Gaussian noise, and increased the similarity to the original signal, as measured by the normalized residual distance, by more than 2.5 times.

Iterative matrix algorithm for high precision temperature and force decoupling in multi-parameter FBG sensing.

PubMed

Hopf, Barbara; Dutz, Franz J; Bosselmann, Thomas; Willsch, Michael; Koch, Alexander W; Roths, Johannes

2018-04-30

A new iterative matrix algorithm has been applied to improve the precision of temperature and force decoupling in multi-parameter FBG sensing. For the first time, this evaluation technique allows the integration of nonlinearities in the sensor's temperature characteristic and the temperature dependence of the sensor's force sensitivity. Applied to a sensor cable consisting of two FBGs in fibers with 80 µm and 125 µm cladding diameter installed in a 7 m-long coiled PEEK capillary, this technique significantly reduced the uncertainties in friction-compensated temperature measurements. In the presence of high friction-induced forces of up to 1.6 N the uncertainties in temperature evaluation were reduced from several degrees Celsius if using a standard linear matrix approach to less than 0.5°C if using the iterative matrix approach in an extended temperature range between -35°C and 125°C.

Filtering techniques for efficient inversion of two-dimensional Nuclear Magnetic Resonance data

NASA Astrophysics Data System (ADS)

Bortolotti, V.; Brizi, L.; Fantazzini, P.; Landi, G.; Zama, F.

2017-10-01

The inversion of two-dimensional Nuclear Magnetic Resonance (NMR) data requires the solution of a first kind Fredholm integral equation with a two-dimensional tensor product kernel and lower bound constraints. For the solution of this ill-posed inverse problem, the recently presented 2DUPEN algorithm [V. Bortolotti et al., Inverse Problems, 33(1), 2016] uses multiparameter Tikhonov regularization with automatic choice of the regularization parameters. In this work, I2DUPEN, an improved version of 2DUPEN that implements Mean Windowing and Singular Value Decomposition filters, is deeply tested. The reconstruction problem with filtered data is formulated as a compressed weighted least squares problem with multi-parameter Tikhonov regularization. Results on synthetic and real 2D NMR data are presented with the main purpose to deeper analyze the separate and combined effects of these filtering techniques on the reconstructed 2D distribution.

Pressure sensitivity analysis of fiber Bragg grating sensors

NASA Astrophysics Data System (ADS)

Mrad, Nezih; Sridharan, Vasant; Kazemi, Alex

2014-09-01

Recent development in fiber optic sensing technology has mainly focused on discrete sensing, particularly, sensing systems with potential multiplexing and multi-parameter capabilities. Bragg grating fiber optic sensors have emerged as the non-disputed champion for multiplexing and simultaneous multi-parameter sensing for emerging high value structural components, advanced processing and manufacturing capabilities and increased critical infrastructure resilience applications. Although the number of potential applications for this sensing technology is large and spans the domains of medicine, manufacturing, aerospace, and public safety; critical issues such as fatigue life, sensitivity, accuracy, embeddability, material/sensor interface integrity, and universal demodulation systems still need to be addressed. The purpose of this paper is to primarily evaluate Commercial-Of-The-Shelf (COTS) Fiber Bragg Grating (FBG) sensors' sensitivity to pressure, often neglected in several applications. The COTS fiber sensitivity to pressure is further evaluated for two types of coatings (Polyimide and Acrylate), and different arrangements (arrayed and single).

Multi-dimensional water quality assessment of an urban drinking water source elucidated by high resolution underwater towed vehicle mapping.

PubMed

Lock, Alan; Spiers, Graeme; Hostetler, Blair; Ray, James; Wallschläger, Dirk

2016-04-15

Spatial surveys of Ramsey Lake, Sudbury, Ontario water quality were conducted using an innovative underwater towed vehicle (UTV) equipped with a multi-parameter probe providing real-time water quality data. The UTV revealed underwater vent sites through high resolution monitoring of different spatial chemical characteristics using common sensors (turbidity, chloride, dissolved oxygen, and oxidation/reduction sensors) that would not be feasible with traditional water sampling methods. Multi-parameter probe vent site identification is supported by elevated alkalinity and silica concentrations at these sites. The identified groundwater vent sites appear to be controlled by bedrock fractures that transport water from different sources with different contaminants of concern. Elevated contaminants, such as, arsenic and nickel and/or nutrient concentrations are evident at the vent sites, illustrating the potential of these sources to degrade water quality. Copyright © 2016 Elsevier Ltd. All rights reserved.

Multiparameter magnetic inspection system with magnetic field control and plural magnetic transducers

DOEpatents

Jiles, David C.

1991-04-16

A multiparameter magnetic inspection system for providing an efficient and economical way to derive a plurality of independent measurements regarding magnetic properties of the magnetic material under investigation. The plurality of transducers for a plurality of different types of measurements operatively connected to the specimen. The transducers are in turn connected to analytical circuits for converting transducer signals to meaningful measurement signals of the magnetic properties of the specimen. The measurement signals are processed and can be simultaneously communicated to a control component. The measurement signals can also be selectively plotted against one another. The control component operates the functioning of the analytical circuits and operates and controls components to impose magnetic fields of desired characteristics upon the specimen. The system therefore allows contemporaneous or simultaneous derivation of the plurality of different independent magnetic properties of the material which can then be processed to derive characteristics of the material.

A multiparameter wearable physiologic monitoring system for space and terrestrial applications

NASA Technical Reports Server (NTRS)

Mundt, Carsten W.; Montgomery, Kevin N.; Udoh, Usen E.; Barker, Valerie N.; Thonier, Guillaume C.; Tellier, Arnaud M.; Ricks, Robert D.; Darling, Robert B.; Cagle, Yvonne D.; Cabrol, Nathalie A.;

Monitoring the Dead Sea Region by Multi-Parameter Stations

NASA Astrophysics Data System (ADS)

Mohsen, A.; Weber, M. H.; Kottmeier, C.; Asch, G.

2015-12-01

The Dead Sea Region is an exceptional ecosystem whose seismic activity has influenced all facets of the development, from ground water availability to human evolution. Israelis, Palestinians and Jordanians living in the Dead Sea region are exposed to severe earthquake hazard. Repeatedly large earthquakes (e.g. 1927, magnitude 6.0; (Ambraseys, 2009)) shook the whole Dead Sea region proving that earthquake hazard knows no borders and damaging seismic events can strike anytime. Combined with the high vulnerability of cities in the region and with the enormous concentration of historical values this natural hazard results in an extreme earthquake risk. Thus, an integration of earthquake parameters at all scales (size and time) and their combination with data of infrastructure are needed with the specific aim of providing a state-of-the-art seismic hazard assessment for the Dead Sea region as well as a first quantitative estimate of vulnerability and risk. A strong motivation for our research is the lack of reliable multi-parameter ground-based geophysical information on earthquakes in the Dead Sea region. The proposed set up of a number of observatories with on-line data access will enable to derive the present-day seismicity and deformation pattern in the Dead Sea region. The first multi-parameter stations were installed in Jordan, Israel and Palestine for long-time monitoring. All partners will jointly use these locations. All stations will have an open data policy, with the Deutsches GeoForschungsZentrum (GFZ, Potsdam, Germany) providing the hard and software for real-time data transmission via satellite to Germany, where all partners can access the data via standard data protocols.

Study of ocean red tide multi-parameter monitoring technology based on double-wavelength airborne lidar system

NASA Astrophysics Data System (ADS)

Lin, Hong; Wang, Xinming; Liang, Kun

2010-10-01

For monitoring and forecasting of the ocean red tide in real time, a marine environment monitoring technology based on the double-wavelength airborne lidar system is proposed. An airborne lidar is father more efficient than the traditional measure technology by the boat. At the same time, this technology can detect multi-parameter about the ocean red tide by using the double-wavelength lidar.It not only can use the infrared laser to detect the scattering signal under the water and gain the information about the red tise's density and size, but also can use the blue-green laser to detect the Brillouin scattering signal and deduce the temperature and salinity of the seawater.The red tide's density detecting model is firstly established by introducing the concept about the red tide scattering coefficient based on the Mie scattering theory. From the Brillouin scattering theory, the relationship about the blue-green laser's Brillouin scattering frequency shift value and power value with the seawater temperature and salinity is found. Then, the detecting mode1 of the saewater temperature and salinity can be established. The value of the red tide infrared scattering signal is evaluated by the simulation, and therefore the red tide particles' density can be known. At the same time, the blue-green laser's Brillouin scattering frequency shift value and power value are evaluated by simulating, and the temperature and salinity of the seawater can be known. Baed on the multi-parameters, the ocean red tide's growth can be monitored and forecasted.

Ranking the Potential Yield of Salinity and Selenium from Subbasins in the Lower Gunnison River Basin Using Seasonal, Multi-parameter Regression Models

NASA Astrophysics Data System (ADS)

Linard, J.; Leib, K.; Colorado Water Science Center

2010-12-01

Elevated levels of salinity and dissolved selenium can detrimentally effect the quality of water where anthropogenic and natural uses are concerned. In areas, such as the lower Gunnison Basin of western Colorado, salinity and selenium are such a concern that control projects are implemented to limit their mobilization. To prioritize the locations in which control projects are implemented, multi-parameter regression models were developed to identify subbasins in the lower Gunnison River Basin that were most likely to have elevated salinity and dissolved selenium levels. The drainage area is about 5,900 mi2 and is underlain by Cretaceous marine shale, which is the most common source of salinity and dissolved selenium. To characterize the complex hydrologic and chemical processes governing constituent mobilization, geospatial variables representing 70 different environmental characteristics were correlated to mean seasonal (irrigation and nonirrigation seasons) salinity and selenium yields estimated at 154 sampling sites. The variables generally represented characteristics of the physical basin, precipitation, soil, geology, land use, and irrigation water delivery systems. Irrigation and nonirrigation seasons were selected due to documented effects of irrigation on constituent mobilization. Following a stepwise approach, combinations of the geospatial variables were used to develop four multi-parameter regression models. These models predicted salinity and selenium yield, within a 95 percent confidence range, at individual points in the Lower Gunnison Basin for irrigation and non-irrigation seasons. The corresponding subbasins were ranked according to their potential to yield salinity and selenium and rankings were used to prioritize areas that would most benefit from control projects.

Combining wood anatomy and stable isotope variations in a 600-year multi-parameter climate reconstruction from Corsican black pine

NASA Astrophysics Data System (ADS)

Szymczak, Sonja; Hetzer, Timo; Bräuning, Achim; Joachimski, Michael M.; Leuschner, Hanns-Hubert; Kuhlemann, Joachim

2014-10-01

We present a new multi-parameter dataset from Corsican black pine growing on the island of Corsica in the Western Mediterranean basin covering the period AD 1410-2008. Wood parameters measured include tree-ring width, latewood width, earlywood width, cell lumen area, cell width, cell wall thickness, modelled wood density, as well as stable carbon and oxygen isotopes. We evaluated the relationships between different parameters and determined the value of the dataset for climate reconstructions. Correlation analyses revealed that carbon isotope ratios are influenced by cell parameters determining cell size, whereas oxygen isotope ratios are influenced by cell parameters determining the amount of transportable water in the xylem. A summer (June to August) precipitation reconstruction dating back to AD 1185 was established based on tree-ring width. No long-term trends or pronounced periods with extreme high/low precipitation are recorded in our reconstruction, indicating relatively stable moisture conditions over the entire time period. By comparing the precipitation reconstruction with a summer temperature reconstruction derived from the carbon isotope chronologies, we identified summers with extreme climate conditions, i.e. warm-dry, warm-wet, cold-dry and cold-wet. Extreme climate conditions during summer months were found to influence cell parameter characteristics. Cold-wet summers promote the production of broad latewood composed of wide and thin-walled tracheids, while warm-wet summers promote the production of latewood with small thick-walled cells. The presented dataset emphasizes the potential of multi-parameter wood analysis from one tree species over long time scales.

The extent to which garments affect the assessment of body shapes of males from faceless CCTV images.

PubMed

Lucas, Teghan; Kumaratilake, Jaliya; Henneberg, Maciej

2014-01-01

Closed circuit television (CCTV) systems are being widely used in crime surveillance. The images produced are of poor quality often face details are not visible, however expert witnesses in the field of biological anthropology use morphological descriptions of body shapes in an attempt to identify persons of interest. These methods can be applied to individual images when other cues such as gait, are not present. Criminals commonly disguise their faces, but body shape characteristics can be used to distinguish a person of interest from others. Garments may distort the body shape appearance, thus this study was undertaken to investigate the effects of garments on the description of body shape from CCTV images. Twelve adult males representing a wide body shape range of Sheldonian somatotypes were photographed in identical garments comprising of tight fitting black shirt, horizontally striped shirt, padded leather jacket and in naked torso. These photographs were assessed by 51 males and females aged 18-50 years, with varying levels of education, and different experience in use of CCTV images for identification of people, to identify the 12 participants. The effect of assessors was not significant. They correctly distinguished 88.6% of individuals wearing the same wear, but could not match the same individuals wearing different wear above the random expectations. However, they matched somatotypes above random expectation. Type of clothing produced little bias in somatotype matching; ectomorphic component of individuals wearing black shirts and padded jackets was overestimated and underestimated, respectively. In conclusion, type of the wear had little effect in the description of individuals from CCTV images using the body shapes.

High precision analytical description of the allowed β spectrum shape

NASA Astrophysics Data System (ADS)

Hayen, Leendert; Severijns, Nathal; Bodek, Kazimierz; Rozpedzik, Dagmara; Mougeot, Xavier

2018-01-01

A fully analytical description of the allowed β spectrum shape is given in view of ongoing and planned measurements. Its study forms an invaluable tool in the search for physics beyond the standard electroweak model and the weak magnetism recoil term. Contributions stemming from finite size corrections, mass effects, and radiative corrections are reviewed. Particular focus is placed on atomic and chemical effects, where the existing description is extended and analytically provided. The effects of QCD-induced recoil terms are discussed, and cross-checks were performed for different theoretical formalisms. Special attention was given to a comparison of the treatment of nuclear structure effects in different formalisms. Corrections were derived for both Fermi and Gamow-Teller transitions, and methods of analytical evaluation thoroughly discussed. In its integrated form, calculated f values were in agreement with the most precise numerical results within the aimed for precision. The need for an accurate evaluation of weak magnetism contributions was stressed, and the possible significance of the oft-neglected induced pseudoscalar interaction was noted. Together with improved atomic corrections, an analytical description was presented of the allowed β spectrum shape accurate to a few parts in 10-4 down to 1 keV for low to medium Z nuclei, thereby extending the work by previous authors by nearly an order of magnitude.

A novel binary shape context for 3D local surface description

NASA Astrophysics Data System (ADS)

Dong, Zhen; Yang, Bisheng; Liu, Yuan; Liang, Fuxun; Li, Bijun; Zang, Yufu

2017-08-01

3D local surface description is now at the core of many computer vision technologies, such as 3D object recognition, intelligent driving, and 3D model reconstruction. However, most of the existing 3D feature descriptors still suffer from low descriptiveness, weak robustness, and inefficiency in both time and memory. To overcome these challenges, this paper presents a robust and descriptive 3D Binary Shape Context (BSC) descriptor with high efficiency in both time and memory. First, a novel BSC descriptor is generated for 3D local surface description, and the performance of the BSC descriptor under different settings of its parameters is analyzed. Next, the descriptiveness, robustness, and efficiency in both time and memory of the BSC descriptor are evaluated and compared to those of several state-of-the-art 3D feature descriptors. Finally, the performance of the BSC descriptor for 3D object recognition is also evaluated on a number of popular benchmark datasets, and an urban-scene dataset is collected by a terrestrial laser scanner system. Comprehensive experiments demonstrate that the proposed BSC descriptor obtained high descriptiveness, strong robustness, and high efficiency in both time and memory and achieved high recognition rates of 94.8%, 94.1% and 82.1% on the considered UWA, Queen, and WHU datasets, respectively.

OPTIMA prelim: a randomised feasibility study of personalised care in the treatment of women with early breast cancer.

PubMed

Stein, Robert C; Dunn, Janet A; Bartlett, John M S; Campbell, Amy F; Marshall, Andrea; Hall, Peter; Rooshenas, Leila; Morgan, Adrienne; Poole, Christopher; Pinder, Sarah E; Cameron, David A; Stallard, Nigel; Donovan, Jenny L; McCabe, Christopher; Hughes-Davies, Luke; Makris, Andreas

2016-02-01

There is uncertainty about the chemotherapy sensitivity of some oestrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancers. Multiparameter assays that measure the expression of several tumour genes simultaneously have been developed to guide the use of adjuvant chemotherapy for this breast cancer subtype. The assays provide prognostic information and have been claimed to predict chemotherapy sensitivity. There is a dearth of prospective validation studies. The Optimal Personalised Treatment of early breast cancer usIng Multiparameter Analysis preliminary study (OPTIMA prelim) is the feasibility phase of a randomised controlled trial (RCT) designed to validate the use of multiparameter assay directed chemotherapy decisions in the NHS. OPTIMA prelim was designed to establish the acceptability to patients and clinicians of randomisation to test-driven treatment assignment compared with usual care and to select an assay for study in the main RCT. Partially blinded RCT with adaptive design. Thirty-five UK hospitals. Patients aged ≥ 40 years with surgically treated ER-positive HER2-negative primary breast cancer and with 1-9 involved axillary nodes, or, if node negative, a tumour at least 30 mm in diameter. Randomisation between two treatment options. Option 1 was standard care consisting of chemotherapy followed by endocrine therapy. In option 2, an Oncotype DX(®) test (Genomic Health Inc., Redwood City, CA, USA) performed on the resected tumour was used to assign patients either to standard care [if 'recurrence score' (RS) was > 25] or to endocrine therapy alone (if RS was ≤ 25). Patients allocated chemotherapy were blind to their randomisation. The pre-specified success criteria were recruitment of 300 patients in no longer than 2 years and, for the final 150 patients, (1) an acceptance rate of at least 40%; (2) recruitment taking no longer than 6 months; and (3) chemotherapy starting within 6 weeks of consent in at least 85% of patients. Between September 2012 and 3 June 2014, 350 patients consented to join OPTIMA prelim and 313 were randomised; the final 150 patients were recruited in 6 months, of whom 92% assigned chemotherapy started treatment within 6 weeks. The acceptance rate for the 750 patients invited to participate was 47%. Twelve out of the 325 patients with data (3.7%, 95% confidence interval 1.7% to 5.8%) were deemed ineligible on central review of receptor status. Interviews with researchers and recordings of potential participant consultations made as part of the integral qualitative recruitment study provided insights into recruitment barriers and led to interventions designed to improve recruitment. Patient information was changed as the result of feedback from three patient focus groups. Additional multiparameter analysis was performed on 302 tumour samples. Although Oncotype DX, MammaPrint(®)/BluePrint(®) (Agendia Inc., Irvine, CA, USA), Prosigna(®) (NanoString Technologies Inc., Seattle, WA, USA), IHC4, IHC4 automated quantitative immunofluorescence (AQUA(®)) [NexCourse BreastTM (Genoptix Inc. Carlsbad, CA, USA)] and MammaTyper(®) (BioNTech Diagnostics GmbH, Mainz, Germany) categorised comparable numbers of tumours into low- or high-risk groups and/or equivalent molecular subtypes, there was only moderate agreement between tests at an individual tumour level (kappa ranges 0.33-0.60 and 0.39-0.55 for tests providing risks and subtypes, respectively). Health economics modelling showed the value of information to the NHS from further research into multiparameter testing is high irrespective of the test evaluated. Prosigna is currently the highest priority for further study. OPTIMA prelim has achieved its aims of demonstrating that a large UK clinical trial of multiparameter assay-based selection of chemotherapy in hormone-sensitive early breast cancer is feasible. The economic analysis shows that a trial would be economically worthwhile for the NHS. Based on the outcome of the OPTIMA prelim, a large-scale RCT to evaluate the clinical effectiveness and cost-effectiveness of multiparameter assay-directed chemotherapy decisions in hormone-sensitive HER2-negative early breast would be appropriate to take place in the NHS. Current Controlled Trials ISRCTN42400492. This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme and will be published in full in Health Technology Assessment; Vol. 20, No. 10. See the NIHR Journals Library website for further project information. The Government of Ontario funded research at the Ontario Institute for Cancer Research. Robert C Stein received additional support from the NIHR University College London Hospitals Biomedical Research Centre.

PROGNOSTIC VALUE OF SHAPE-DESCRIPTIVE FACTORS FOR THE PROGRESSION OF GEOGRAPHIC ATROPHY SECONDARY TO AGE-RELATED MACULAR DEGENERATION.

PubMed

Pfau, Maximilian; Lindner, Moritz; Goerdt, Lukas; Thiele, Sarah; Nadal, Jennifer; Schmid, Matthias; Schmitz-Valckenberg, Steffen; Sadda, SriniVas R; Holz, Frank G; Fleckenstein, Monika

2018-05-16

To systematically compare the prognostic value of multiple shape-descriptive factors in the natural course of the disease. A total of 296 eyes of 201 patients (female patients 130; mean age: 72.2 ± 13.08 years) with a median follow-up of 2.38 years from 2 prospective, noninterventional natural history studies (Fundus-Autofluorescence-in-Age-related-Macular-Degeneration [clinicaltrials.gov identifier NCT00393692], Directional-Spread-in-Geographic-Atrophy [NCT02051998]) were included in the analysis. Serial fundus autofluorescence images were annotated using semiautomated image analysis software to determine the lesion area, circularity, perimeter, and caliper diameters. These variables and the fundus autofluorescence phenotype were evaluated for prediction of the future square root progression rates using linear mixed-effects models. For the combined model, leave-one-out cross validation on patient level (Scenario 1: previously unknown patient) resulted in a goodness-to-fit (R value) of 0.244 and leave-one-out cross validation on visit level (Scenario 2: previous observation of the patient) in a R value of 0.391. This indicated that shape-descriptive factors could explain 24.4% of the variance in geographic atrophy progression in previously unknown patients and 39.1% in patients with previous observation. These findings confirm the relevance of shape-descriptive factors and previous progression as prognostic variables for geographic atrophy progression. However, a substantial part of the remaining variation in geographic atrophy progression seems to depend on other variables, some of which are visible in optical coherence tomography.

Analytic Description of Critical Point Nuclei in a Spherical-Axially Deformed Shape Phase Transition

DOE Office of Scientific and Technical Information (OSTI.GOV)

Iachello, F.

2001-07-30

An approximate solution at the critical point of the spherical to axially deformed shape phase transition in nuclei is presented. The eigenvalues of the Hamiltonian are expressed in terms of zeros of Bessel functions of irrational order.

A review on the systematic formulation of 3-D multiparameter full waveform inversion in viscoelastic medium

NASA Astrophysics Data System (ADS)

Yang, Pengliang; Brossier, Romain; Métivier, Ludovic; Virieux, Jean

2016-10-01

In this paper, we study 3-D multiparameter full waveform inversion (FWI) in viscoelastic media based on the generalized Maxwell/Zener body including arbitrary number of attenuation mechanisms. We present a frequency-domain energy analysis to establish the stability condition of a full anisotropic viscoelastic system, according to zero-valued boundary condition and the elastic-viscoelastic correspondence principle: the real-valued stiffness matrix becomes a complex-valued one in Fourier domain when seismic attenuation is taken into account. We develop a least-squares optimization approach to linearly relate the quality factor with the anelastic coefficients by estimating a set of constants which are independent of the spatial coordinates, which supplies an explicit incorporation of the parameter Q in the general viscoelastic wave equation. By introducing the Lagrangian multipliers into the matrix expression of the wave equation with implicit time integration, we build a systematic formulation of multiparameter FWI for full anisotropic viscoelastic wave equation, while the equivalent form of the state and adjoint equation with explicit time integration is available to be resolved efficiently. In particular, this formulation lays the foundation for the inversion of the parameter Q in the time domain with full anisotropic viscoelastic properties. In the 3-D isotropic viscoelastic settings, the anelastic coefficients and the quality factors using bulk and shear moduli parametrization can be related to the counterparts using P and S velocity. Gradients with respect to any other parameter of interest can be found by chain rule. Pioneering numerical validations as well as the real applications of this most generic framework will be carried out to disclose the potential of viscoelastic FWI when adequate high-performance computing resources and the field data are available.

Variety of geologic silhouette shapes distinguishable by multiple rotations method of quantitative shape analysis text

DOE Office of Scientific and Technical Information (OSTI.GOV)

Collins, D.G.; Parks, J.M.

1984-04-01

Silhouette shapes are two-dimensional projections of three-dimensional objects such as sand grains, gravel, and fossils. Within-the-margin markings such as chamber boundaries, sutures, or ribs are ignored. Comparisons between populations of objects from similar and differential origins (i.e., environments, species or genera, growth series, etc) is aided by quantifying the shapes. The Multiple Rotations Method (MRM) uses a variation of ''eigenshapes'', which is capable of distinguishing most of the subtle variations that the ''trained eye'' can detect. With a video-digitizer and microcomputer, MRM is fast, more accurate, and more objective than the human eye. The resulting shape descriptors comprise 5 ormore » 6 numbers per object that can be stored and retrieved to compare with similar descriptions of other objects. The original-shape outlines can be reconstituted sufficiently for gross recognition from these few numerical descriptors. Thus, a semi-automated data-retrieval system becomes feasible, with silhouette-shape descriptions as one of several recognition criteria. MRM consists of four ''rotations'': rotation about a center to a comparable orientation; a principal-components rotation to reduce the many original shape descriptors to a few; a VARIMAX orthogonal-factor rotation to achieve simple structure; and a rotation to achieve factor scores on individual objects. A variety of subtly different shapes includes sand grains from several locations, ages, and environments, and fossils of several types. This variety illustrates the feasibility of quantitative comparisons by MRM.« less

Description of transitional nuclei in the sdg boson model

NASA Astrophysics Data System (ADS)

Lac, V.-S.; Kuyucak, S.

1992-03-01

We study the transitional nuclei in the framework of the sdg boson model. This extension is necessitated by recent measurements of E2 and E4 transitions in the Pt and Os isotopes which can not be explained in the sd boson models. We show how γ-unstable and triaxial shapes arise from special choices of sdg model hamiltonians and discuss ways of limiting the number of free parameters through consistency and coherence conditions. A satisfactory description of E2 and E4 properties is obtained for the Pt and Os nuclei, which also predicts dynamic shape transitions in these nuclei.

Theoretical description of magnetocaloric effect in the shape memory alloy exhibiting metamagnetic behavior

DOE Office of Scientific and Technical Information (OSTI.GOV)

L'vov, Victor A.; Taras Shevchenko National University, Kyiv 01601; Kosogor, Anna, E-mail: annakosogor@gmail.com

2016-01-07

A simple thermodynamic theory is proposed for the quantitative description of giant magnetocaloric effect observed in metamagnetic shape memory alloys. Both the conventional magnetocaloric effect at the Curie temperature and the inverse magnetocaloric effect at the transition from the ferromagnetic austenite to a weakly magnetic martensite are considered. These effects are evaluated from the Landau-type free energy expression involving exchange interactions in a system of a two magnetic sublattices. The findings of the thermodynamic theory agree with first-principles calculations and experimental results from Ni-Mn-In-Co and Ni-Mn-Sn alloys, respectively.

LASER APPLICATIONS AND OTHER TOPICS IN QUANTUM ELECTRONICS: Application of the Wigner function and matrix optics to describe variations in the shape of ultrashort laser pulses propagating through linear optical systems

NASA Astrophysics Data System (ADS)

Gitin, Andrey V.

2006-04-01

The transformation of the shape of ultrashort laser pulses (USPs) in time can be described similarly to the process of image formation in space. It is shown that the wave description of imaging is simplified by using the Wigner function, this description in the quadratic approximation being identical to the use of the ABCD matrices. The transformation of USPs propagating through linear optical systems was described and these systems were classified by the methods of matrix optics.

Achieving quantum precision limit in adaptive qubit state tomography

NASA Astrophysics Data System (ADS)

Hou, Zhibo; Zhu, Huangjun; Xiang, Guo-Yong; Li, Chuan-Feng; Guo, Guang-Can

2016-02-01

The precision limit in quantum state tomography is of great interest not only to practical applications but also to foundational studies. However, little is known about this subject in the multiparameter setting even theoretically due to the subtle information trade-off among incompatible observables. In the case of a qubit, the theoretic precision limit was determined by Hayashi as well as Gill and Massar, but attaining the precision limit in experiments has remained a challenging task. Here we report the first experiment that achieves this precision limit in adaptive quantum state tomography on optical polarisation qubits. The two-step adaptive strategy used in our experiment is very easy to implement in practice. Yet it is surprisingly powerful in optimising most figures of merit of practical interest. Our study may have significant implications for multiparameter quantum estimation problems, such as quantum metrology. Meanwhile, it may promote our understanding about the complementarity principle and uncertainty relations from the information theoretic perspective.

Millimeter wave radiative transfer studies for precipitation measurements

NASA Technical Reports Server (NTRS)

Vivekanandan, J.; Evans, Frank

1989-01-01

Scattering calculations using the discrete dipole approximation and vector radiative transfer calculations were performed to model multiparameter radar return and passive microwave emission for a simple model of a winter storm. The issue of dendrite riming was addressed by computing scattering properties of thin ice disks with varying bulk density. It was shown that C-band multiparameter radar contains information about particle density and the number concentration of the ice particles. The radiative transfer modeling indicated that polarized multifrequency passive microwave emission may be used to infer some properties of ice hydrometers. Detailed radar modeling and vector radiative transfer modeling is in progress to enhance the understanding of simultaneous radar and radiometer measurements, as in the case of the proposed TRMM field program. A one-dimensional cloud model will be used to simulate the storm structure in detail and study the microphysics, such as size and density. Multifrequency polarized radiometer measurements from the SSMI satellite instrument will be analyzed in relation to dual-frequency and dual-polarization radar measurements.

Detection of Rossby Waves in Multi-Parameters in Multi-Mission Satellite Observations and HYCOM Simulations in the Indian Ocean

NASA Technical Reports Server (NTRS)

Subrahmanyam, Bulusu; Heffner, David M.; Cromwell, David; Shriver, Jay F.

2009-01-01

Rossby waves are difficult to detect with in situ methods. However, as we show in this paper, they can be clearly identified in multi-parameters in multi-mission satellite observations of sea surface height (SSH), sea surface temperature (SST) and ocean color observations of chlorophyll-a (chl-a), as well as 1/12-deg global HYbrid Coordinate Ocean Model (HYCOM) simulations of SSH, SST and sea surface salinity (SSS) in the Indian Ocean. While the surface structure of Rossby waves can be elucidated from comparisons of the signal in different sea surface parameters, models are needed to gain direct information about how these waves affect the ocean at depth. The first three baroclinic modes of the Rossby waves are inferred from the Fast Fourier Transform (FFT), and two-dimensional Radon Transform (2D RT). At many latitudes the first and second baroclinic mode Rossby wave phase speeds from satellite observations and model parameters are identified.

Quantitative Assessment of Retinopathy Using Multi-parameter Image Analysis

PubMed Central

Ghanian, Zahra; Staniszewski, Kevin; Jamali, Nasim; Sepehr, Reyhaneh; Wang, Shoujian; Sorenson, Christine M.; Sheibani, Nader; Ranji, Mahsa

2016-01-01

A multi-parameter quantification method was implemented to quantify retinal vascular injuries in microscopic images of clinically relevant eye diseases. This method was applied to wholemount retinal trypsin digest images of diabetic Akita/+, and bcl-2 knocked out mice models. Five unique features of retinal vasculature were extracted to monitor early structural changes and retinopathy, as well as quantifying the disease progression. Our approach was validated through simulations of retinal images. Results showed fewer number of cells (P = 5.1205e-05), greater population ratios of endothelial cells to pericytes (PCs) (P = 5.1772e-04; an indicator of PC loss), higher fractal dimension (P = 8.2202e-05), smaller vessel coverage (P = 1.4214e-05), and greater number of acellular capillaries (P = 7.0414e-04) for diabetic retina as compared to normal retina. Quantification using the present method would be helpful in evaluating physiological and pathological retinopathy in a high-throughput and reproducible manner. PMID:27186534

Microwave radiative transfer studies of precipitation

NASA Technical Reports Server (NTRS)

Bringi, V. N.; Vivekanandan, J.; Turk, F. Joseph

1993-01-01

Since the deployment of the DMSP SSM/I microwave imagers in 1987, increased utilization of passive microwave radiometry throughout the 10 - 100 GHz spectrum has occurred for measurement of atmospheric constituents and terrestrial surfaces. Our efforts have focused on observations and analysis of the microwave radiative transfer behavior of precipitating clouds. We have focused particular attention on combining both aircraft and SSM/I radiometer imagery with ground-based multiparameter radar observations. As part of this and the past NASA contract, we have developed a multi-stream, polarized radiative transfer model which incorporates scattering. The model has the capability to be initialized with cloud model output or multiparameter radar products. This model provides the necessary 'link' between the passive microwave radiometer and active microwave radar observations. This unique arrangement has allowed the brightness temperatures (TB) to be compared against quantities such as rainfall, liquid/ice water paths, and the vertical structure of the cloud. Quantification of the amounts of ice and water in precipitating clouds is required for understanding of the global energy balance.

Self-Powered Multiparameter Health Sensor.

PubMed

Tobola, Andreas; Leutheuser, Heike; Pollak, Markus; Spies, Peter; Hofmann, Christian; Weigand, Christian; Eskofier, Bjoern M; Fischer, Georg

2018-01-01

Wearable health sensors are about to change our health system. While several technological improvements have been presented to enhance performance and energy-efficiency, battery runtime is still a critical concern for practical use of wearable biomedical sensor systems. The runtime limitation is directly related to the battery size, which is another concern regarding practicality and customer acceptance. We introduced ULPSEK-Ultra-Low-Power Sensor Evaluation Kit-for evaluation of biomedical sensors and monitoring applications (http://ulpsek.com). ULPSEK includes a multiparameter sensor measuring and processing electrocardiogram, respiration, motion, body temperature, and photoplethysmography. Instead of a battery, ULPSEK is powered using an efficient body heat harvester. The harvester produced 171 W on average, which was sufficient to power the sensor below 25 C ambient temperature. We present design issues regarding the power supply and the power distribution network of the ULPSEK sensor platform. Due to the security aspect of self-powered health sensors, we suggest a hybrid solution consisting of a battery charged by a harvester.

High spatial resolution distributed fiber system for multi-parameter sensing based on modulated pulses.

PubMed

Zhang, Jingdong; Zhu, Tao; Zhou, Huan; Huang, Shihong; Liu, Min; Huang, Wei

2016-11-28

We demonstrate a cost-effective distributed fiber sensing system for the multi-parameter detection of the vibration, the temperature, and the strain by integrating phase-sensitive optical time domain reflectometry (φ-OTDR) and Brillouin optical time domain reflectometry (B-OTDR). Taking advantage of the fast changing property of the vibration and the static properties of the temperature and the strain, both the width and intensity of the laser pulses are modulated and injected into the single-mode sensing fiber proportionally, so that three concerned parameters can be extracted simultaneously by only one photo-detector and one data acquisition channel. A data processing method based on Gaussian window short time Fourier transform (G-STFT) is capable of achieving high spatial resolution in B-OTDR. The experimental results show that up to 4.8kHz vibration sensing with 3m spatial resolution at 10km standard single-mode fiber can be realized, as well as the distributed temperature and stress profiles along the same fiber with 80cm spatial resolution.

AMON: a wearable multiparameter medical monitoring and alert system.

PubMed

Anliker, Urs; Ward, Jamie A; Lukowicz, Paul; Tröster, Gerhard; Dolveck, François; Baer, Michel; Keita, Fatou; Schenker, Eran B; Catarsi, Fabrizio; Coluccini, Luca; Belardinelli, Andrea; Shklarski, Dror; Alon, Menachem; Hirt, Etienne; Schmid, Rolf; Vuskovic, Milica

2004-12-01

This paper describes an advanced care and alert portable telemedical monitor (AMON), a wearable medical monitoring and alert system targeting high-risk cardiac/respiratory patients. The system includes continuous collection and evaluation of multiple vital signs, intelligent multiparameter medical emergency detection, and a cellular connection to a medical center. By integrating the whole system in an unobtrusive, wrist-worn enclosure and applying aggressive low-power design techniques, continuous long-term monitoring can be performed without interfering with the patients' everyday activities and without restricting their mobility. In the first two and a half years of this EU IST sponsored project, the AMON consortium has designed, implemented, and tested the described wrist-worn device, a communication link, and a comprehensive medical center software package. The performance of the system has been validated by a medical study with a set of 33 subjects. The paper describes the main concepts behind the AMON system and presents details of the individual subsystems and solutions as well as the results of the medical validation.

Creation of Novel Cores for β-Secretase (BACE-1) Inhibitors: A Multiparameter Lead Generation Strategy

PubMed Central

2014-01-01

In order to find optimal core structures as starting points for lead optimization, a multiparameter lead generation workflow was designed with the goal of finding BACE-1 inhibitors as a treatment for Alzheimer’s disease. De novo design of core fragments was connected with three predictive in silico models addressing target affinity, permeability, and hERG activity, in order to guide synthesis. Taking advantage of an additive SAR, the prioritized cores were decorated with a few, well-characterized substituents from known BACE-1 inhibitors in order to allow for core-to-core comparisons. Prediction methods and analyses of how physicochemical properties of the core structures correlate to in vitro data are described. The syntheses and in vitro data of the test compounds are reported in a separate paper by Ginman et al. [J. Med. Chem.2013, 56, 4181–4205]. The affinity predictions are described in detail by Roos et al. [J. Chem. Inf.2014, DOI: 10.1021/ci400374z]. PMID:24900855

Creation of Novel Cores for β-Secretase (BACE-1) Inhibitors: A Multiparameter Lead Generation Strategy.

PubMed

Viklund, Jenny; Kolmodin, Karin; Nordvall, Gunnar; Swahn, Britt-Marie; Svensson, Mats; Gravenfors, Ylva; Rahm, Fredrik

2014-04-10

In order to find optimal core structures as starting points for lead optimization, a multiparameter lead generation workflow was designed with the goal of finding BACE-1 inhibitors as a treatment for Alzheimer's disease. De novo design of core fragments was connected with three predictive in silico models addressing target affinity, permeability, and hERG activity, in order to guide synthesis. Taking advantage of an additive SAR, the prioritized cores were decorated with a few, well-characterized substituents from known BACE-1 inhibitors in order to allow for core-to-core comparisons. Prediction methods and analyses of how physicochemical properties of the core structures correlate to in vitro data are described. The syntheses and in vitro data of the test compounds are reported in a separate paper by Ginman et al. [J. Med. Chem. 2013, 56, 4181-4205]. The affinity predictions are described in detail by Roos et al. [J. Chem. Inf. 2014, DOI: 10.1021/ci400374z].

Multivariate meta-analysis for non-linear and other multi-parameter associations

PubMed Central

Gasparrini, A; Armstrong, B; Kenward, M G

2012-01-01

In this paper, we formalize the application of multivariate meta-analysis and meta-regression to synthesize estimates of multi-parameter associations obtained from different studies. This modelling approach extends the standard two-stage analysis used to combine results across different sub-groups or populations. The most straightforward application is for the meta-analysis of non-linear relationships, described for example by regression coefficients of splines or other functions, but the methodology easily generalizes to any setting where complex associations are described by multiple correlated parameters. The modelling framework of multivariate meta-analysis is implemented in the package mvmeta within the statistical environment R. As an illustrative example, we propose a two-stage analysis for investigating the non-linear exposure–response relationship between temperature and non-accidental mortality using time-series data from multiple cities. Multivariate meta-analysis represents a useful analytical tool for studying complex associations through a two-stage procedure. Copyright © 2012 John Wiley & Sons, Ltd. PMID:22807043

Polygon Properties: What Is Possible?

ERIC Educational Resources Information Center

Rodrigue, Paulette R.; Robichaux, Rebecca R.

2010-01-01

Sorting shapes and solving riddles develop and advance children's geometric thinking and understanding while promoting mathematical communication, cooperative learning, and numerous representations. This article presents a brief summary of how children develop an understanding of the properties of geometric shapes as well as a description of the…

Description of cysticercoid of Coronacanthus vassilevi Genov, 1980 (Cestoda:Hymenolepididae).

PubMed

Tkach, V V

1994-06-01

Genus Coronacanthus Spassky, 1954 contains three species--C. integra (Hamann, 1891), C. omissa (Baer et Joyeux 1943) and C. vassilevi Genov, 1980--but larval stages of only first two species were described before. During 1991-1993 cysticercoids of all three species were found from gammarid crustaceans in Eastern Carpathians. The article contains an illustrated description of the cysticercoid of C. vassilevi. It differs considerably from the formerly known Coronacanthus larvae by the egg-shaped (not lens-shaped) form of the cyst, absence of marginal thickening of the cyst wall, by the shape and length of cercomer and besides, by the invagination of the anterior part of the scolex. Microvilli on the cyst surface were not detected with light microscope. Cercomer of C. vassilevi is narrow and very long as for mammalian hymenolepidid (4.7 to 8 times longer than cyst). The number (37-38), length (8-9 microns) and shape of rostellar hooks well correspond to those of adult worms (Genov, 1980).

Computer program analyzes and designs supersonic wing-body combinations

NASA Technical Reports Server (NTRS)

Woodward, F. A.

1968-01-01

Computer program formulates geometric description of the wing body configuration, optimizes wing camber shape, determines wing shape for a given pressure distribution, and calculates pressures, forces, and moments on a given configuration. The program consists of geometry definition, transformation, and paneling, and aerodynamics, and flow visualization.

Are U-Shaped Developmental Trajectories Illusory?

ERIC Educational Resources Information Center

Vouloumanos, Athena

2011-01-01

Without criteria for what counts as a U/N-shaped developmental trajectory, it is not clear how many legitimate "Us" really exist. Many, if not all, "Us" may turn out to be illusions borne out of our sampling methods, task construal, and blurry lenses of description. (Contains 2 figures.)

Interfacing Email Tutoring: Shaping an Emergent Literate Practice.

ERIC Educational Resources Information Center

Anderson, Dana

2002-01-01

Presents a descriptive analysis of 29 online writing lab sites for email tutoring, currently the most popular mode of computer-mediated collaboration. Considers how email tutoring interfaces represent the literate practice of email tutoring, shaping expectations and experiences consistent with its literate aims. Suggests that email tutoring…

Trends Shaping Education 2010

ERIC Educational Resources Information Center

OECD Publishing (NJ3), 2010

2010-01-01

"Trends Shaping Education 2010" brings together evidence showing the effects on education of globalisation, social challenges, changes in the workplace, the transformation of childhood, and ICT. To make the content accessible, each trend is presented on a double page, containing an introduction, two charts with brief descriptive text and a set of…

Military Airlift: C-17 Aircraft Program

DTIC Science & Technology

2007-06-05

cigar-shaped airships, a hybrid airship is shaped more like an aircraft’s wing, to generate lift through aerodynamic forces. Advocates hope that such...Appendix 1. System Description60 Power Plant: Four Pratt & Whitney F117-PW-100 turbofan engines Wingspan: 169 feet 10 inches (to winglet tips) (51.76

Prototype of an Integrated Hurricane Information System for Research: Description and Illustration of its Use in Evaluating WRF Model Simulations

NASA Astrophysics Data System (ADS)

Hristova-Veleva, S.; Chao, Y.; Vane, D.; Lambrigtsen, B.; Li, P. P.; Knosp, B.; Vu, Q. A.; Su, H.; Dang, V.; Fovell, R.; Tanelli, S.; Garay, M.; Willis, J.; Poulsen, W.; Fishbein, E.; Ao, C. O.; Vazquez, J.; Park, K. J.; Callahan, P.; Marcus, S.; Haddad, Z.; Fetzer, E.; Kahn, R.

2007-12-01

In spite of recent improvements in hurricane track forecast accuracy, currently there are still many unanswered questions about the physical processes that determine hurricane genesis, intensity, track and impact on large- scale environment. Furthermore, a significant amount of work remains to be done in validating hurricane forecast models, understanding their sensitivities and improving their parameterizations. None of this can be accomplished without a comprehensive set of multiparameter observations that are relevant to both the large- scale and the storm-scale processes in the atmosphere and in the ocean. To address this need, we have developed a prototype of a comprehensive hurricane information system of high- resolution satellite, airborne and in-situ observations and model outputs pertaining to: i) the thermodynamic and microphysical structure of the storms; ii) the air-sea interaction processes; iii) the larger-scale environment as depicted by the SST, ocean heat content and the aerosol loading of the environment. Our goal was to create a one-stop place to provide the researchers with an extensive set of observed hurricane data, and their graphical representation, together with large-scale and convection-resolving model output, all organized in an easy way to determine when coincident observations from multiple instruments are available. Analysis tools will be developed in the next step. The analysis tools will be used to determine spatial, temporal and multiparameter covariances that are needed to evaluate model performance, provide information for data assimilation and characterize and compare observations from different platforms. We envision that the developed hurricane information system will help in the validation of the hurricane models, in the systematic understanding of their sensitivities and in the improvement of the physical parameterizations employed by the models. Furthermore, it will help in studying the physical processes that affect hurricane development and impact on large-scale environment. This talk will describe the developed prototype of the hurricane information systems. Furthermore, we will use a set of WRF hurricane simulations and compare simulated to observed structures to illustrate how the information system can be used to discriminate between simulations that employ different physical parameterizations. The work described here was performed at the Jet Propulsion Laboratory, California Institute of Technology, under contract with the National Aeronautics ans Space Administration.

Representation and visualization of variability in a 3D anatomical atlas using the kidney as an example

NASA Astrophysics Data System (ADS)

Hacker, Silke; Handels, Heinz

2006-03-01

Computer-based 3D atlases allow an interactive exploration of the human body. However, in most cases such 3D atlases are derived from one single individual, and therefore do not regard the variability of anatomical structures concerning their shape and size. Since the geometric variability across humans plays an important role in many medical applications, our goal is to develop a framework of an anatomical atlas for representation and visualization of the variability of selected anatomical structures. The basis of the project presented is the VOXEL-MAN atlas of inner organs that was created from the Visible Human data set. For modeling anatomical shapes and their variability we utilize "m-reps" which allow a compact representation of anatomical objects on the basis of their skeletons. As an example we used a statistical model of the kidney that is based on 48 different variants. With the integration of a shape description into the VOXEL-MAN atlas it is now possible to query and visualize different shape variations of an organ, e.g. by specifying a person's age or gender. In addition to the representation of individual shape variants, the average shape of a population can be displayed. Besides a surface representation, a volume-based representation of the kidney's shape variants is also possible. It results from the deformation of the reference kidney of the volume-based model using the m-rep shape description. In this way a realistic visualization of the shape variants becomes possible, as well as the visualization of the organ's internal structures.

Multi-Parameter Linear Least-Squares Fitting to Poisson Data One Count at a Time

NASA Technical Reports Server (NTRS)

Wheaton, W.; Dunklee, A.; Jacobson, A.; Ling, J.; Mahoney, W.; Radocinski, R.

1993-01-01

A standard problem in gamma-ray astronomy data analysis is the decomposition of a set of observed counts, described by Poisson statistics, according to a given multi-component linear model, with underlying physical count rates or fluxes which are to be estimated from the data.

A new species of Tereancistrum (Monogenea, Dactylogyridae) from the gills of three Leporinus species (Characiformes, Anostomidae) and a revised description of Tereancistrum parvus.

PubMed

Zago, Aline C; Yamada, Fábio H; Franceschini, Lidiane; Bongiovani, Marcela F; Yamada, Priscilla O F; Silva, Reinaldo J DA

2017-01-01

The present study describes Tereancistrum flabellum n. sp. (Dactylogyridae, Ancyrocephalinae) from the gills of the anostomid fishes Leporinus friderici, Leporinus amblyrhynchus and Leporinus elongatus from two freshwater ecosystems in the south east of Brazil. This new species is mainly characterized by the morphology of the copulatory complex (such as the MCO base formed by two fan-shaped structures, and accessory piece flattened, curved, rigid and channeled), a dorsal anchor with a well-developed superficial and inconspicuous deep root, and the shape of the accessory anchor sclerite with small spathulate termination. Tereancistrum flabellum n. sp. is the first record of a dactylogyrid from L. amblyrhynchus. The description of Tereancistrum parvus is also emended to correct and complement previous descriptions and the species is reported for the first time in Schizodon nasutus.

Imagery Ability and Task Performance.

DTIC Science & Technology

1983-01-24

expected both the reaction times and the error rates to be higher for the more difficult trials on each dimension, and this was true in the curvature and... true and two false assertions about "* the spatial relationships between the shapes in that particular 13 configuration. An example of one...the shapes, the shapes were returned to the experimenter and the subject was given a booklet containing the ten descriptions, each on a separate page

Aspects of Shape Coexistence in the Geometric Collective Model of Nuclei

NASA Astrophysics Data System (ADS)

Georgoudis, P. E.; Leviatan, A.

2018-02-01

We examine the coexistence of spherical and γ-unstable deformed nuclear shapes, described by an SO(5)-invariant Bohr Hamiltonian, along the critical-line. Calculations are performed in the Algebraic Collective Model by introducing two separate bases, optimized to accommodate simultaneously different forms of dynamics. We demonstrate the need to modify the β-dependence of the moments of inertia, in order to obtain an adequate description of such shape-coexistence.

Nanowire growth from the viewpoint of the thin film polylayer growth theory

NASA Astrophysics Data System (ADS)

Kashchiev, Dimo

2018-03-01

The theory of polylayer growth of thin solid films is employed for description of the growth kinetics of single-crystal nanowires. Expressions are derived for the dependences of the height h and radius r of a given nanowire on time t, as well as for the h(r) dependence. These dependences are applicable immediately after the nanowire nucleation on the substrate and thus include the period during which the nucleated nanowire changes its shape from that of cap to that of column. The analysis shows that the nanowire cap-to-column shape transition is continuous and makes it possible to kinetically define the nanowire shape-transition radius by means of the nanowire radial and axial growth rates. The obtained h(t), r(t) and h(r) dependences are found to provide a good description of available experimental data for growth of self-nucleated GaN nanowires by the vapor-solid mechanism.

Impact of Single-Case Pupil Descriptions on Student Teacher Attitudes towards Inclusive Education

ERIC Educational Resources Information Center

Röhm, Alexander; Schnöring, Annika; Hastall, Matthias R.

2018-01-01

Institutional and individual stigmatization are still major barriers for children with disabilities to access education. Teacher attitudes towards inclusive education play a crucial role in this regard, and are shaped by single-case descriptions from mass media or other sources. Building on exemplification theory and priming, two experiments with…

Improved object optimal synthetic description, modeling, learning, and discrimination by GEOGINE computational kernel

NASA Astrophysics Data System (ADS)

Fiorini, Rodolfo A.; Dacquino, Gianfranco

2005-03-01

GEOGINE (GEOmetrical enGINE), a state-of-the-art OMG (Ontological Model Generator) based on n-D Tensor Invariants for n-Dimensional shape/texture optimal synthetic representation, description and learning, was presented in previous conferences elsewhere recently. Improved computational algorithms based on the computational invariant theory of finite groups in Euclidean space and a demo application is presented. Progressive model automatic generation is discussed. GEOGINE can be used as an efficient computational kernel for fast reliable application development and delivery in advanced biomedical engineering, biometric, intelligent computing, target recognition, content image retrieval, data mining technological areas mainly. Ontology can be regarded as a logical theory accounting for the intended meaning of a formal dictionary, i.e., its ontological commitment to a particular conceptualization of the world object. According to this approach, "n-D Tensor Calculus" can be considered a "Formal Language" to reliably compute optimized "n-Dimensional Tensor Invariants" as specific object "invariant parameter and attribute words" for automated n-Dimensional shape/texture optimal synthetic object description by incremental model generation. The class of those "invariant parameter and attribute words" can be thought as a specific "Formal Vocabulary" learned from a "Generalized Formal Dictionary" of the "Computational Tensor Invariants" language. Even object chromatic attributes can be effectively and reliably computed from object geometric parameters into robust colour shape invariant characteristics. As a matter of fact, any highly sophisticated application needing effective, robust object geometric/colour invariant attribute capture and parameterization features, for reliable automated object learning and discrimination can deeply benefit from GEOGINE progressive automated model generation computational kernel performance. Main operational advantages over previous, similar approaches are: 1) Progressive Automated Invariant Model Generation, 2) Invariant Minimal Complete Description Set for computational efficiency, 3) Arbitrary Model Precision for robust object description and identification.

16 CFR 305.3 - Description of covered products.

Code of Federal Regulations, 2011 CFR

2011-01-01

... operation. Some models may require user intervention to initiate these different segments of the cycle after... inner reflective coating on the outer bulb to direct the light, an R, PAR, or similar bulb shapes... bulb to direct the light, an R, PAR, ER, BR, BPAR, or similar bulb shapes with E26 medium screw bases...

The Community College of the Future.

ERIC Educational Resources Information Center

Terrey, John N.

An overview is provided of the challenges facing community colleges due to the shift from a global society shaped by political philosophies to a society shaped by economic powers. Introductory comments are followed by a description of recent changes in the world community, including the rise of Japan, South Korea, Singapore, Taiwan, Thailand, and…

Nondestructive testing methods to predict effect of degradation on wood : a critical assessment

Treesearch

J. Kaiserlik

1978-01-01

Results are reported for an assessment of methods for predicting strength of wood, wood-based, or related material. Research directly applicable to nondestructive strength prediction was very limited. In wood, strength prediction research is limited to vibration decay, wave attenuation, and multiparameter "degradation models." Nonwood methods with potential...

Enrollment Forecasting: A Report of the National Dissemination Project for the Community Colleges.

ERIC Educational Resources Information Center

Maxie, Francoise

A systems approach, a multiparameter stochastic model, that will project State vocational education needs is being developed in Washington State by cooperation of the Coordinating Council for Occupational Education with Dr. Samuel Cleff. The model has incorporated the Cleff Career Development Systems (CCDS), a job matching system used for…

The Shock and Vibration Digest, Volume 18, Number 2

DTIC Science & Technology

1986-02-01

Bounce Response of Canadian 71. McMunn, J.C., "Multi-Parameter Optimum MAGLEV Vehicle under Guideway Excitation. . Damping in Linear Dynamical Systems...Northeast Corridor High-Speed Test Cars," J. "Suspension Bounce Response of Canadian L’,-*’-.-" Engrg. Indus., Trans. ASME, 91B (3), pp 897-907 MAGLEV

Relationships between digital signal processing and control and estimation theory

NASA Technical Reports Server (NTRS)

Willsky, A. S.

1978-01-01

Research areas associated with digital signal processing and control and estimation theory are identified. Particular attention is given to image processing, system identification problems (parameter identification, linear prediction, least squares, Kalman filtering), stability analyses (the use of the Liapunov theory, frequency domain criteria, passivity), and multiparameter systems, distributed processes, and random fields.

Postdoctoral Fellow | Center for Cancer Research

Cancer.gov

The positions will provide excellent training opportunities in mucosal immunology.  The ideal candidates must be able to work independently and have demonstrated abilities in clear scientific project planning and reporting.  Experience in multiparameter flow cytometry, gene expression analysis, intestinal cell isolation, and mouse models of disease is desirable.  One position

A Bayesian Method for Evaluating Trainee Proficiency. Technical Paper 323.

ERIC Educational Resources Information Center

Epstein, Kenneth I.; Steinheiser, Frederick H., Jr.

A multiparameter, programmable model was developed to examine the interactive influence of certain parameters on the probability of deciding that an examinee had attained a specified degree of mastery. It was applied within the simulated context of performance testing of military trainees. These parameters included: (1) the number of assumed…

Thermal stability control system of photo-elastic interferometer in the PEM-FTs

NASA Astrophysics Data System (ADS)

Zhang, M. J.; Jing, N.; Li, K. W.; Wang, Z. B.

2018-01-01

A drifting model for the resonant frequency and retardation amplitude of a photo-elastic modulator (PEM) in the photo-elastic modulated Fourier transform spectrometer (PEM-FTs) is presented. A multi-parameter broadband-matching driving control method is proposed to improve the thermal stability of the PEM interferometer. The automatically frequency-modulated technology of the driving signal based on digital phase-locked technology is used to track the PEM's changing resonant frequency. Simultaneously the maximum optical-path-difference of a laser's interferogram is measured to adjust the amplitude of the PEM's driving signal so that the spectral resolution is stable. In the experiment, the multi-parameter broadband-matching control method is applied to the driving control system of the PEM-FTs. Control of resonant frequency and retardation amplitude stabilizes the maximum optical-path-difference to approximately 236 μm and results in a spectral resolution of 42 cm-1. This corresponds to a relative error smaller than 2.16% (4.28 standard deviation). The experiment shows that the method can effectively stabilize the spectral resolution of the PEM-FTs.

Multi-parameter analysis using photovoltaic cell-based optofluidic cytometer

PubMed Central

Yan, Chien-Shun; Wang, Yao-Nan

2016-01-01

A multi-parameter optofluidic cytometer based on two low-cost commercial photovoltaic cells and an avalanche photodetector is proposed. The optofluidic cytometer is fabricated on a polydimethylsiloxane (PDMS) substrate and is capable of detecting side scattered (SSC), extinction (EXT) and fluorescence (FL) signals simultaneously using a free-space light transmission technique without the need for on-chip optical waveguides. The feasibility of the proposed device is demonstrated by detecting fluorescent-labeled polystyrene beads with sizes of 3 μm, 5 μm and 10 μm, respectively, and label-free beads with a size of 7.26 μm. The detection experiments are performed using both single-bead population samples and mixed-bead population samples. The detection results obtained using the SSC/EXT, EXT/FL and SSC/FL signals are compared with those obtained using a commercial flow cytometer. It is shown that the optofluidic cytometer achieves a high detection accuracy for both single-bead population samples and mixed-bead population samples. Consequently, the proposed device provides a versatile, straightforward and low-cost solution for a wide variety of point-of-care (PoC) cytometry applications. PMID:27699122

Multi-parameters monitoring during traditional Chinese medicine concentration process with near infrared spectroscopy and chemometrics

NASA Astrophysics Data System (ADS)

Liu, Ronghua; Sun, Qiaofeng; Hu, Tian; Li, Lian; Nie, Lei; Wang, Jiayue; Zhou, Wanhui; Zang, Hengchang

2018-03-01

As a powerful process analytical technology (PAT) tool, near infrared (NIR) spectroscopy has been widely used in real-time monitoring. In this study, NIR spectroscopy was applied to monitor multi-parameters of traditional Chinese medicine (TCM) Shenzhiling oral liquid during the concentration process to guarantee the quality of products. Five lab scale batches were employed to construct quantitative models to determine five chemical ingredients and physical change (samples density) during concentration process. The paeoniflorin, albiflorin, liquiritin and samples density were modeled by partial least square regression (PLSR), while the content of the glycyrrhizic acid and cinnamic acid were modeled by support vector machine regression (SVMR). Standard normal variate (SNV) and/or Savitzkye-Golay (SG) smoothing with derivative methods were adopted for spectra pretreatment. Variable selection methods including correlation coefficient (CC), competitive adaptive reweighted sampling (CARS) and interval partial least squares regression (iPLS) were performed for optimizing the models. The results indicated that NIR spectroscopy was an effective tool to successfully monitoring the concentration process of Shenzhiling oral liquid.

A versatile system for the rapid collection, handling and graphics analysis of multidimensional data

NASA Astrophysics Data System (ADS)

O'Brien, P. M.; Moloney, G.; O'Connor, A.; Legge, G. J. F.

1993-05-01

The aim of this work was to provide a versatile system for handling multiparameter data that may arise from a variety of experiments — nuclear, AMS, microprobe elemental analysis, 3D microtomography etc. Some of the most demanding requirements arise in the application of microprobes to quantitative elemental mapping and to microtomography. A system to handle data from such experiments had been under continuous development and use at MARC for the past 15 years. It has now been made adaptable to the needs of multiparameter (or single parameter) experiments in general. The original system has been rewritten, greatly expanded and made much more powerful and faster, by use of modern computer technology — a VME bus computer with a real time operating system and a RISC workstation running Unix and the X Window system. This provides the necessary (i) power, speed and versatility, (ii) expansion and updating capabilities (iii) standardisation and adaptability, (iv) coherent modular programming structures, (v) ability to interface to other programs and (vi) transparent operation with several levels, involving the use of menus, programmed function keys and powerful macro programming facilities.

Sequential injection system with multi-parameter analysis capability for water quality measurement.

PubMed

Kaewwonglom, Natcha; Jakmunee, Jaroon

2015-11-01

A simple sequential injection (SI) system with capability to determine multi-parameter has been developed for the determination of iron, manganese, phosphate and ammonium. A simple and compact colorimeter was fabricated in the laboratory to be employed as a detector. The system was optimized for suitable conditions for determining each parameter by changing software program and without reconfiguration of the hardware. Under the optimum conditions, the methods showed linear ranges of 0.2-10 mg L(-1) for iron and manganese determinations, and 0.3-5.0 mg L(-1) for phosphate and ammonium determinations, with correlation coefficients of 0.9998, 0.9973, 0.9987 and 0.9983, respectively. The system provided detection limits of 0.01, 0.14, 0.004 and 0.02 mg L(-1) for iron, manganese, phosphate and ammonium, respectively. The proposed system has good precision, low chemical consumption and high throughput. It was applied for monitoring water quality of Ping river in Chiang Mai, Thailand. Recoveries of the analysis were obtained in the range of 82-119%. Copyright © 2015 Elsevier B.V. All rights reserved.

Prototype of a low cost multiparameter probe

NASA Astrophysics Data System (ADS)

Koski, K.; Schwingle, R.; Pullin, M.

2010-12-01

Commercial multi-parameter probes provide accurate, high-resolution temporal data collection of a variety of water quality parameters, but their cost (>5,000) prohibits more than a few sampling locations. We present a design and prototype for a low cost (<250) probe. The cost of the probe is ~5% of commercially available probes, allowing for data collection from ~20 times more sampling points in a field location. The probe is constructed from a single-board microcontroller, a commercially available temperature sensor, a conductivity sensor, and a fabricated optical rhodamine sensor. Using a secure digital (SD) memory card, the probe can record over a month of data at a user specified interval. Construction, calibration, field deployment and data retrieval can be accomplished by a skilled undergraduate. Initial deployment will take place as part of a tracer test in the Valles Caldera National Preserve in northern New Mexico. Future work includes: addition of commercial ion selective electrodes (pH, bromide, nitrate, and others); construction of optically based sensors (chlorophyll, dissolved oxygen, and others); wireless networking between the sensors; and reduction of biofouling.

Seismo-Geochemical Variations in SW Taiwan: Multi-Parameter Automatic Gas Monitoring Results

NASA Astrophysics Data System (ADS)

Yang, T. F.; Fu, C.-C.; Walia, V.; Chen, C.-H.; Chyi, L. L.; Liu, T.-K.; Song, S.-R.; Lee, M.; Lin, C.-W.; Lin, C.-C.

2006-04-01

Gas variations of many mud volcanoes and hot springs distributed along the tectonic sutures in southwestern Taiwan are considered to be sensitive to the earthquake activity. Therefore, a multi-parameter automatic gas station was built on the bank of one of the largest mud-pools at an active fault zone of southwestern Taiwan, for continuous monitoring of CO2, CH4, N2 and H2O, the major constituents of its bubbling gases. During the year round monitoring from October 2001 to October 2002, the gas composition, especially, CH4 and CO2, of the mud pool showed significant variations. Taking the CO2/CH4 ratio as the main indicator, anomalous variations can be recognized from a few days to a few weeks before earthquakes and correlated well with those with a local magnitude >4.0 and local intensities >2. It is concluded that the gas composition in the area is sensitive to the local crustal stress/strain and is worthy to conduct real-time monitoring for the seismo-geochemical precursors.

How can we maximize the diagnostic utility of uroflow?: ICI-RS 2017.

PubMed

Gammie, Andrew; Rosier, Peter; Li, Rui; Harding, Chris

2018-01-09

To gauge the current level of diagnostic utility of uroflowmetry and to suggest areas needing research to improve this. A summary of the debate held at the 2017 meeting of the International Consultation on Incontinence Research Society, with subsequent analysis by the authors. Limited diagnostic sensitivity and specificity exist for maximum flow rates, multiple uroflow measurements, and flow-volume nomograms. There is a lack of clarity in flow rate curve shape description and uroflow time measurement. There is a need for research to combine uroflowmetry with other non-invasive indicators. Better standardizations of test technique, flow-volume nomograms, uroflow shape descriptions, and time measurements are required. © 2017 Wiley Periodicals, Inc.

Advanced Spatial-Division Multiplexed Measurement Systems Propositions—From Telecommunication to Sensing Applications: A Review

PubMed Central

Weng, Yi; Ip, Ezra; Pan, Zhongqi; Wang, Ting

2016-01-01

The concepts of spatial-division multiplexing (SDM) technology were first proposed in the telecommunications industry as an indispensable solution to reduce the cost-per-bit of optical fiber transmission. Recently, such spatial channels and modes have been applied in optical sensing applications where the returned echo is analyzed for the collection of essential environmental information. The key advantages of implementing SDM techniques in optical measurement systems include the multi-parameter discriminative capability and accuracy improvement. In this paper, to help readers without a telecommunication background better understand how the SDM-based sensing systems can be incorporated, the crucial components of SDM techniques, such as laser beam shaping, mode generation and conversion, multimode or multicore elements using special fibers and multiplexers are introduced, along with the recent developments in SDM amplifiers, opto-electronic sources and detection units of sensing systems. The examples of SDM-based sensing systems not only include Brillouin optical time-domain reflectometry or Brillouin optical time-domain analysis (BOTDR/BOTDA) using few-mode fibers (FMF) and the multicore fiber (MCF) based integrated fiber Bragg grating (FBG) sensors, but also involve the widely used components with their whole information used in the full multimode constructions, such as the whispering gallery modes for fiber profiling and chemical species measurements, the screw/twisted modes for examining water quality, as well as the optical beam shaping to improve cantilever deflection measurements. Besides, the various applications of SDM sensors, the cost efficiency issue, as well as how these complex mode multiplexing techniques might improve the standard fiber-optic sensor approaches using single-mode fibers (SMF) and photonic crystal fibers (PCF) have also been summarized. Finally, we conclude with a prospective outlook for the opportunities and challenges of SDM technologies in optical sensing industry. PMID:27589754

Research on remote sensing identification of rural abandoned homesteads using multiparameter characteristics method

NASA Astrophysics Data System (ADS)

Xu, Saiping; Zhao, Qianjun; Yin, Kai; Cui, Bei; Zhang, Xiupeng

2016-10-01

Hollow village is a special phenomenon in the process of urbanization in China, which causes the waste of land resources. Therefore, it's imminent to carry out the hollow village recognition and renovation. However, there are few researches on the remote sensing identification of hollow village. In this context, in order to recognize the abandoned homesteads by remote sensing technique, the experiment was carried out as follows. Firstly, Gram-Schmidt transform method was utilized to complete the image fusion between multi-spectral images and panchromatic image of WorldView-2. Then the fusion images were made edge enhanced by high pass filtering. The multi-resolution segmentation and spectral difference segmentation were carried out to obtain the image objects. Secondly, spectral characteristic parameters were calculated, such as the normalized difference vegetation index (NDVI), the normalized difference water index (NDWI), the normalized difference Soil index (NDSI) etc. The shape feature parameters were extracted, such as Area, Length/Width Ratio and Rectangular Fit etc.. Thirdly, the SEaTH algorithm was used to determine the thresholds and optimize the feature space. Furthermore, the threshold classification method and the random forest classifier were combined, and the appropriate amount of samples were selected to train the classifier in order to determine the important feature parameters and the best classifier parameters involved in classification. Finally, the classification results was verified by computing the confusion matrix. The classification results were continuous and the phenomenon of salt and pepper using pixel classification was avoided effectively. In addition, the results showed that the extracted Abandoned Homesteads were in complete shapes, which could be distinguished from those confusing classes such as Homestead in Use and Roads.

Advanced Spatial-Division Multiplexed Measurement Systems Propositions-From Telecommunication to Sensing Applications: A Review.

PubMed

Weng, Yi; Ip, Ezra; Pan, Zhongqi; Wang, Ting

2016-08-30

The concepts of spatial-division multiplexing (SDM) technology were first proposed in the telecommunications industry as an indispensable solution to reduce the cost-per-bit of optical fiber transmission. Recently, such spatial channels and modes have been applied in optical sensing applications where the returned echo is analyzed for the collection of essential environmental information. The key advantages of implementing SDM techniques in optical measurement systems include the multi-parameter discriminative capability and accuracy improvement. In this paper, to help readers without a telecommunication background better understand how the SDM-based sensing systems can be incorporated, the crucial components of SDM techniques, such as laser beam shaping, mode generation and conversion, multimode or multicore elements using special fibers and multiplexers are introduced, along with the recent developments in SDM amplifiers, opto-electronic sources and detection units of sensing systems. The examples of SDM-based sensing systems not only include Brillouin optical time-domain reflectometry or Brillouin optical time-domain analysis (BOTDR/BOTDA) using few-mode fibers (FMF) and the multicore fiber (MCF) based integrated fiber Bragg grating (FBG) sensors, but also involve the widely used components with their whole information used in the full multimode constructions, such as the whispering gallery modes for fiber profiling and chemical species measurements, the screw/twisted modes for examining water quality, as well as the optical beam shaping to improve cantilever deflection measurements. Besides, the various applications of SDM sensors, the cost efficiency issue, as well as how these complex mode multiplexing techniques might improve the standard fiber-optic sensor approaches using single-mode fibers (SMF) and photonic crystal fibers (PCF) have also been summarized. Finally, we conclude with a prospective outlook for the opportunities and challenges of SDM technologies in optical sensing industry.

The Locus of the Focus of a Rolling Parabola

ERIC Educational Resources Information Center

Agarwal, Anurag; Marengo, James

2010-01-01

The catenary is usually introduced as the shape assumed by a hanging flexible cable. This is a "physical" description of a catenary. In this article we give a "geometrical" description of a catenary. Specifically we show that the catenary is the locus of the focus of a certain parabola as it rolls on the x-axis.

Shape Mode Analysis Exposes Movement Patterns in Biology: Flagella and Flatworms as Case Studies

PubMed Central

Werner, Steffen; Rink, Jochen C.; Riedel-Kruse, Ingmar H.; Friedrich, Benjamin M.

2014-01-01

We illustrate shape mode analysis as a simple, yet powerful technique to concisely describe complex biological shapes and their dynamics. We characterize undulatory bending waves of beating flagella and reconstruct a limit cycle of flagellar oscillations, paying particular attention to the periodicity of angular data. As a second example, we analyze non-convex boundary outlines of gliding flatworms, which allows us to expose stereotypic body postures that can be related to two different locomotion mechanisms. Further, shape mode analysis based on principal component analysis allows to discriminate different flatworm species, despite large motion-associated shape variability. Thus, complex shape dynamics is characterized by a small number of shape scores that change in time. We present this method using descriptive examples, explaining abstract mathematics in a graphic way. PMID:25426857

A Multi-Parameter Approach for Calculating Crack Instability

NASA Technical Reports Server (NTRS)

Zanganeh, M.; Forman, R. G.

2014-01-01

An accurate fracture control analysis of spacecraft pressure systems, boosters, rocket hardware and other critical low-cycle fatigue cases where the fracture toughness highly impacts cycles to failure requires accurate knowledge of the material fracture toughness. However, applicability of the measured fracture toughness values using standard specimens and transferability of the values to crack instability analysis of the realistically complex structures is refutable. The commonly used single parameter Linear Elastic Fracture Mechanics (LEFM) approach which relies on the key assumption that the fracture toughness is a material property would result in inaccurate crack instability predictions. In the past years extensive studies have been conducted to improve the single parameter (K-controlled) LEFM by introducing parameters accounting for the geometry or in-plane constraint effects]. Despite the importance of the thickness (out-of-plane constraint) effects in fracture control problems, the literature is mainly limited to some empirical equations for scaling the fracture toughness data] and only few theoretically based developments can be found. In aerospace hardware where the structure might have only one life cycle and weight reduction is crucial, reducing the design margin of safety by decreasing the uncertainty involved in fracture toughness evaluations would result in lighter hardware. In such conditions LEFM would not suffice and an elastic-plastic analysis would be vital. Multi-parameter elastic plastic crack tip field quantifying developments combined with statistical methods] have been shown to have the potential to be used as a powerful tool for tackling such problems. However, these approaches have not been comprehensively scrutinized using experimental tests. Therefore, in this paper a multi-parameter elastic-plastic approach has been used to study the crack instability problem and the transferability issue by considering the effects of geometrical constraints as well as the thickness. The feasibility of the approach has been examined using a wide range of specimen geometries and thicknesses manufactured from 7075-T7351 aluminum alloy.

Impact of pre-transplantation minimal residual disease determined by multiparameter flow cytometry on the outcome of AML patients with FLT3-ITD after allogeneic stem cell transplantation.

PubMed

Zhao, Xiaosu; Wang, Zhidong; Ruan, Guorui; Liu, Yanrong; Wang, Yu; Zhang, Xiaohui; Xu, Lanping; Huang, Xiaojun; Chang, Yingjun

2018-06-01

In this study, using multiparameter flow cytometry (FCM), we investigate the impact of minimal residual disease prior to transplantation (pre-MRD) on the transplant outcomes of AML patients with fms-related tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD) mutation. A total of 20 patients who received HLA-matched sibling donor transplantation (MSDT) and 63 patients who received unmanipulated haploidentical hematopoietic stem cell transplantation (haplo-HSCT) were enrolled. Patients were classified into four groups based on the status of pre-FCM: group 1 with positive pre-FCM before MSDT, group 2 with negative pre-FCM before MSDT, group 3 with positive pre-FCM before haplo-HSCT, and group 4 with positive pre-FCM before haplo-HSCT. The results showed that patients in group 1 had the highest cumulative incidence of relapse (2-year CIR, 75.0%), the lowest leukemia-free survival (2-year LFS, 33.3%), and the overall survival (2-year OS, 25.0%) among all four groups. The other three groups of patients had comparable CIR (2-year CIR: group 2 vs. 3 vs. 4, 12.5% vs. 31.3% vs. 22.2%, P > 0.05) and LFS (2-year LFS: group 2 vs. 3 vs. 4, 87.5% vs. 62.5% vs. 66.5%, P > 0.05). Multivariate analysis indicated that disease status (> CR) and pre-MRD were associated with a higher CIR and a lower LFS when patients were classified by pre-MRD and transplant type. Our results suggested that AML patients with FLT3-ITD were able to be separated into high-risk and low-risk relapse groups based on pre-MRD, as determined by multiparameter FCM. Haplo-HSCT might overcome the negative impact of pre-MRD on patient outcomes compared to MSDT. These results require further investigation in prospective study with large numbers of cases.

Sharing, Trading, Stealing: Exploring the Role of Peers in Shaping Foods Available at Lunchtime

ERIC Educational Resources Information Center

Sutter, Carolyn; Nishina, Adrienne; Scherr, Rachel E.; Zidenberg-Cherr, Sheri; Ontai, Lenna L.

2016-01-01

Childhood obesity continues to be a major concern in the United States, warranting a comprehensive approach. However, the majority of research studies continue to neglect the influence of peers on dietary behaviors. The present descriptive study aimed to provide information about the ways peers directly shape dietary choices via food exchanges…

Advanced Life Support System Value Metric

NASA Technical Reports Server (NTRS)

Jones, Harry W.; Arnold, James O. (Technical Monitor)

1999-01-01

The NASA Advanced Life Support (ALS) Program is required to provide a performance metric to measure its progress in system development. Extensive discussions within the ALS program have reached a consensus. The Equivalent System Mass (ESM) metric has been traditionally used and provides a good summary of the weight, size, and power cost factors of space life support equipment. But ESM assumes that all the systems being traded off exactly meet a fixed performance requirement, so that the value and benefit (readiness, performance, safety, etc.) of all the different systems designs are exactly equal. This is too simplistic. Actual system design concepts are selected using many cost and benefit factors and the system specification is then set accordingly. The ALS program needs a multi-parameter metric including both the ESM and a System Value Metric (SVM). The SVM would include safety, maintainability, reliability, performance, use of cross cutting technology, and commercialization potential. Another major factor in system selection is technology readiness level (TRL), a familiar metric in ALS. The overall ALS system metric that is suggested is a benefit/cost ratio, [SVM + TRL]/ESM, with appropriate weighting and scaling. The total value is the sum of SVM and TRL. Cost is represented by ESM. The paper provides a detailed description and example application of the suggested System Value Metric.

GENPLOT: A formula-based Pascal program for data manipulation and plotting

NASA Astrophysics Data System (ADS)

Kramer, Matthew J.

Geochemical processes involving alteration, differentiation, fractionation, or migration of elements may be elucidated by a number of discrimination or variation diagrams (e.g., AFM, Harker, Pearce, and many others). The construction of these diagrams involves arithmetic combination of selective elements (involving major, minor, or trace elements). GENPLOT utilizes a formula-based algorithm (an expression parser) which enables the program to manipulate multiparameter databases and plot XY, ternary, tetrahedron, and REE type plots without needing to change either the source code or rearranging databases. Formulae may be any quadratic expression whose variables are the column headings of the data matrix. A full-screen editor with limited equations and arithmetic functions (spreadsheet) has been incorporated into the program to aid data entry and editing. Data are stored as ASCII files to facilitate interchange of data between other programs and computers. GENPLOT was developed in Turbo Pascal for the IBM and compatible computers but also is available in Apple Pascal for the Apple Ile and Ill. Because the source code is too extensive to list here (about 5200 lines of Pascal code), the expression parsing routine, which is central to GENPLOT's flexibility is incorporated into a smaller demonstration program named SOLVE. The following paper includes a discussion on how the expression parser works and a detailed description of GENPLOT's capabilities.

Hydrologic data and description of a hydrologic monitoring plan for Medicine Lake Volcano, California

USGS Publications Warehouse

Schneider, Tiffany Rae; McFarland, W.D.

1996-01-01

A hydrologic reconnaissance of the Medicine Lake Volcano area was done to collect data needed for the design of a hydrologic monitoring plan. The reconnaissance was completed during two field trips made in June and September 1992, during which geothermal and hydrologic features of public interest in the Medicine Lake area were identified. Selected wells, springs, and geothermal features were located and documented, and initial water-level, discharge, temperature, and specific-conductance measurements were made. Lakes in the study area also were surveyed during the September field trip. Temperature, specific- conductance, dissolved oxygen, and pH data were collected by using a multiparameter probe. The proposed monitoring plan includes measurement of water levels in wells, discharge from springs, and lake stage, as well as analysis of well-,spring-, and lake-water quality. In determining lake-water quality, data for both stratified and unstratified conditions would be considered. (Data for stratified conditions were collected during the reconnaissance phase of this project, but data for unstratified conditions were not.) In addition, lake stage also would be monitored. A geothermal feature near Medicine Lake is a "hot spot" from which hot gases discharge from two distinct vents. Gas chemistry and temperature would be monitored in one of these vents.

Description of saturation curves and boiling process of dry air

NASA Astrophysics Data System (ADS)

Vestfálová, Magda; Petříková, Markéta; Šimko, Martin

2018-06-01

Air is a mixture of gases forming the gas wrap of Earth. It is formed by dry air, moisture and other pollutants. Dry air is a substance whose thermodynamic properties in gaseous state, as well as the thermodynamic properties of its main constituents in gaseous state, are generally known and described in detail in the literature. The liquid air is a bluish liquid and is industrially used to produce oxygen, nitrogen, argon and helium by distillation. The transition between the gaseous and liquid state (the condensation process, resp. boiling process), is usually displayed in the basic thermodynamic diagrams using the saturation curves. The saturation curves of all pure substances are of a similar shape. However, since the dry air is a mixture, the shapes of its saturation curves are modified relative to the shapes corresponding to the pure substances. This paper deals with the description of the dry air saturation curves as a mixture, i.e. with a description of the process of phase change of dry air (boiling process). The dry air saturation curves are constructed in the basic thermodynamic charts based on the values obtained from the literature. On the basis of diagrams, data appearing in various publications are interpreted and put into context with boiling process of dry air.

The challenge associated with the robust computation of meteor velocities from video and photographic records

NASA Astrophysics Data System (ADS)

Egal, A.; Gural, P. S.; Vaubaillon, J.; Colas, F.; Thuillot, W.

2017-09-01

The CABERNET project was designed to push the limits for obtaining accurate measurements of meteoroids orbits from photographic and video meteor camera recordings. The discrepancy between the measured and theoretic orbits of these objects heavily depends on the semi-major axis determination, and thus on the reliability of the pre-atmospheric velocity computation. With a spatial resolution of 0.01° per pixel and a temporal resolution of up to 10 ms, CABERNET should be able to provide accurate measurements of velocities and trajectories of meteors. To achieve this, it is necessary to improve the precision of the data reduction processes, and especially the determination of the meteor's velocity. In this work, most of the steps of the velocity computation are thoroughly investigated in order to reduce the uncertainties and error contributions at each stage of the reduction process. The accuracy of the measurement of meteor centroids is established and results in a precision of 0.09 pixels for CABERNET, which corresponds to 3.24‧‧. Several methods to compute the velocity were investigated based on the trajectory determination algorithms described in Ceplecha (1987) and Borovicka (1990), as well as the multi-parameter fitting (MPF) method proposed by Gural (2012). In the case of the MPF, many optimization methods were implemented in order to find the most efficient and robust technique to solve the minimization problem. The entire data reduction process is assessed using simulated meteors, with different geometrical configurations and deceleration behaviors. It is shown that the multi-parameter fitting method proposed by Gural(2012)is the most accurate method to compute the pre-atmospheric velocity in all circumstances. Many techniques that assume constant velocity at the beginning of the path as derived from the trajectory determination using Ceplecha (1987) or Borovicka (1990) can lead to large errors for decelerating meteors. The MPF technique also allows one to reliably compute the velocity for very low convergence angles (∼ 1°). Despite the better accuracy of this method, the poor conditioning of the velocity propagation models used in the meteor community and currently employed by the multi-parameter fitting method prevent us from optimally computing the pre-atmospheric velocity. Specifically, the deceleration parameters are particularly difficult to determine. The quality of the data provided by the CABERNET network limits the error induced by this effect to achieve an accuracy of about 1% on the velocity computation. Such a precision would not be achievable with lower resolution camera networks and today's commonly used trajectory reduction algorithms. To improve the performance of the multi-parameter fitting method, a linearly independent deceleration formulation needs to be developed.

Increased serum bicarbonate in critically ill patients: a retrospective analysis.

PubMed

Libório, Alexandre Braga; Noritomi, Danilo Teixeira; Leite, Tacyano Tavares; de Melo Bezerra, Candice Torres; de Faria, Evandro Rodrigues; Kellum, John A

2015-03-01

Although metabolic alkalosis is a common occurrence, no study has evaluated its prevalence, associated factors or outcomes in critically ill patients. This is a retrospective study from the Multiparameter Intelligent Monitoring in Intensive Care II database. From 23,529 adult patient records, 18,982 patients met the inclusion criteria. Serum bicarbonate levels demonstrated a U-shaped association with mortality with knots at 25 and 30 mEq/l. Of the total included patients, 5,565 (29.3 %) had at least one serum bicarbonate level measurement >30 mEq/l. The majority were exposed to multiple factors that are classically associated with metabolic alkalosis (mainly diuretic use, hypernatremia, hypokalemia and high gastric output). Patients with increased serum bicarbonate exhibited increased ICU LOS, more days on mechanical ventilation and higher hospital mortality. After multivariate adjustment, each 5-mEq/l increment in the serum bicarbonate level above 30 mEq/l was associated with an odds ratio of 1.21 for hospital mortality. The association between increased serum bicarbonate levels and mortality occurs independently of its possible etiologies. An increased serum bicarbonate level is common in critically ill patients; this can be attributed to multiple factors in the majority of cases, and its presence and duration negatively influence patient outcomes.

Time-lapse electrical impedance spectroscopy for monitoring the cell cycle of single immobilized S. pombe cells.

PubMed

Zhu, Zhen; Frey, Olivier; Haandbaek, Niels; Franke, Felix; Rudolf, Fabian; Hierlemann, Andreas

2015-11-26

As a complement and alternative to optical methods, wide-band electrical impedance spectroscopy (EIS) enables multi-parameter, label-free and real-time detection of cellular and subcellular features. We report on a microfluidics-based system designed to reliably capture single rod-shaped Schizosaccharomyces pombe cells by applying suction through orifices in a channel wall. The system enables subsequent culturing of immobilized cells in an upright position, while dynamic changes in cell-cycle state and morphology were continuously monitored through EIS over a broad frequency range. Besides measuring cell growth, clear impedance signals for nuclear division have been obtained. The EIS system has been characterized with respect to sensitivity and detection limits. The spatial resolution in measuring cell length was 0.25 μm, which corresponds to approximately a 5-min interval of cell growth under standard conditions. The comprehensive impedance data sets were also used to determine the occurrence of nuclear division and cytokinesis. The obtained results have been validated through concurrent confocal imaging and plausibilized through comparison with finite-element modeling data. The possibility to monitor cellular and intracellular features of single S. pombe cells during the cell cycle at high spatiotemporal resolution renders the presented microfluidics-based EIS system a suitable tool for dynamic single-cell investigations.

Time-lapse electrical impedance spectroscopy for monitoring the cell cycle of single immobilized S. pombe cells

PubMed Central

Zhu, Zhen; Frey, Olivier; Haandbaek, Niels; Franke, Felix; Rudolf, Fabian; Hierlemann, Andreas

2015-01-01

As a complement and alternative to optical methods, wide-band electrical impedance spectroscopy (EIS) enables multi-parameter, label-free and real-time detection of cellular and subcellular features. We report on a microfluidics-based system designed to reliably capture single rod-shaped Schizosaccharomyces pombe cells by applying suction through orifices in a channel wall. The system enables subsequent culturing of immobilized cells in an upright position, while dynamic changes in cell-cycle state and morphology were continuously monitored through EIS over a broad frequency range. Besides measuring cell growth, clear impedance signals for nuclear division have been obtained. The EIS system has been characterized with respect to sensitivity and detection limits. The spatial resolution in measuring cell length was 0.25 μm, which corresponds to approximately a 5-min interval of cell growth under standard conditions. The comprehensive impedance data sets were also used to determine the occurrence of nuclear division and cytokinesis. The obtained results have been validated through concurrent confocal imaging and plausibilized through comparison with finite-element modeling data. The possibility to monitor cellular and intracellular features of single S. pombe cells during the cell cycle at high spatiotemporal resolution renders the presented microfluidics-based EIS system a suitable tool for dynamic single-cell investigations. PMID:26608589

The decomposition of deformation: New metrics to enhance shape analysis in medical imaging.

PubMed

Varano, Valerio; Piras, Paolo; Gabriele, Stefano; Teresi, Luciano; Nardinocchi, Paola; Dryden, Ian L; Torromeo, Concetta; Puddu, Paolo E

2018-05-01

In landmarks-based Shape Analysis size is measured, in most cases, with Centroid Size. Changes in shape are decomposed in affine and non affine components. Furthermore the non affine component can be in turn decomposed in a series of local deformations (partial warps). If the extent of deformation between two shapes is small, the difference between Centroid Size and m-Volume increment is barely appreciable. In medical imaging applied to soft tissues bodies can undergo very large deformations, involving large changes in size. The cardiac example, analyzed in the present paper, shows changes in m-Volume that can reach the 60%. We show here that standard Geometric Morphometrics tools (landmarks, Thin Plate Spline, and related decomposition of the deformation) can be generalized to better describe the very large deformations of biological tissues, without losing a synthetic description. In particular, the classical decomposition of the space tangent to the shape space in affine and non affine components is enriched to include also the change in size, in order to give a complete description of the tangent space to the size-and-shape space. The proposed generalization is formulated by means of a new Riemannian metric describing the change in size as change in m-Volume rather than change in Centroid Size. This leads to a redefinition of some aspects of the Kendall's size-and-shape space without losing Kendall's original formulation. This new formulation is discussed by means of simulated examples using 2D and 3D platonic shapes as well as a real example from clinical 3D echocardiographic data. We demonstrate that our decomposition based approaches discriminate very effectively healthy subjects from patients affected by Hypertrophic Cardiomyopathy. Copyright © 2018 Elsevier B.V. All rights reserved.

Measurement Techniques for Hypervelocity Impact Test Fragments

NASA Technical Reports Server (NTRS)

Hill, Nicole E.

2008-01-01

The ability to classify the size and shape of individual orbital debris fragments provides a better understanding of the orbital debris environment as a whole. The characterization of breakup fragmentation debris has gradually evolved from a simplistic, spherical assumption towards that of describing debris in terms of size, material, and shape parameters. One of the goals of the NASA Orbital Debris Program Office is to develop high-accuracy techniques to measure these parameters and apply them to orbital debris observations. Measurement of the physical characteristics of debris resulting from groundbased, hypervelocity impact testing provides insight into the shapes and sizes of debris produced from potential impacts in orbit. Current techniques for measuring these ground-test fragments require determination of dimensions based upon visual judgment. This leads to reduced accuracy and provides little or no repeatability for the measurements. With the common goal of mitigating these error sources, allaying any misunderstandings, and moving forward in fragment shape determination, the NASA Orbital Debris Program Office recently began using a computerized measurement system. The goal of using these new techniques is to improve knowledge of the relation between commonly used dimensions and overall shape. The immediate objective is to scan a single fragment, measure its size and shape properties, and import the fragment into a program that renders a 3D model that adequately demonstrates how the object could appear in orbit. This information would then be used to aid optical methods in orbital debris shape determination. This paper provides a description of the measurement techniques used in this initiative and shows results of this work. The tradeoffs of the computerized methods are discussed, as well as the means of repeatability in the measurements of these fragments. This paper serves as a general description of methods for the measurement and shape analysis of orbital debris.

Nematodes from galls on Myrtaceae. VII. Fergusobia from 'leafy' leaf bud galls in Australia, with re-description of Fergusobia tumifaciens (Currie 1937) Wachek 1955 and descriptions of Fergusobia planchonianae n. sp. and Fergusobia viminalisae n. sp.

PubMed

Davies, Kerrie A; Ye, Weimin; Giblin-Davis, Robin M; Taylor, Gary S; Hodda, Mike; Thomas, W Kelley

2014-08-26

Fergusobia tumifaciens (Currie 1937) Wachek 1955, the type species for the genus Fergusobia, is re-described from specimens collected from 'leafy' leaf bud galls on Eucalyptus bridgesiana near Albury in New South Wales, Australia. It is morphologically characterized by the combination of an open C-shaped parthenogenetic female with a small broadly conoid tail, a C-shaped infective female with a bluntly rounded tail tip, and an arcuate to J-shaped male with angular spicules, not heavily sclerotised, and short to mid-length peloderan bursa. Two new species of Fergusobia, collected from 'leafy' leaf bud galls on, respectively, Eucalyptus planchoniana in Queensland, and E. viminalis in South Australia, Australia, are described. Fergusobia planchonianae Davies n. sp. is characterised by the combination of a C-shaped parthenogenetic female with a conoid tail, an arcuate infective female with an hemispherical tail tip, and an almost straight to arcuate to C-shaped male with an angular spicule, a long peloderan bursa and a narrow tail. Fergusobia viminalisae Davies n. sp. is characterised by the combination of an open C-shaped parthenogenetic female with a broadly conoid tail, a C-shaped infective female with a bluntly rounded tail tip, and an arcuate to J-shaped male with an angular (not heavily sclerotised) spicule and short to mid-length peloderan bursa. The shield morphologies of the fly larvae associated with the 'leafy' leaf bud galls and their possible relationships are outlined. Possible evolutionary relationships of the Fergusobia nematodes from these galls are discussed, considering their morphology, DNA sequences, and the relationships of the associated Fergusonina flies and host plants. 

Information fusion based techniques for HEVC

NASA Astrophysics Data System (ADS)

Fernández, D. G.; Del Barrio, A. A.; Botella, Guillermo; Meyer-Baese, Uwe; Meyer-Baese, Anke; Grecos, Christos

2017-05-01

Aiming at the conflict circumstances of multi-parameter H.265/HEVC encoder system, the present paper introduces the analysis of many optimizations' set in order to improve the trade-off between quality, performance and power consumption for different reliable and accurate applications. This method is based on the Pareto optimization and has been tested with different resolutions on real-time encoders.

Multi-view information fusion for automatic BI-RADS description of mammographic masses

NASA Astrophysics Data System (ADS)

Narvaez, Fabián; Díaz, Gloria; Romero, Eduardo

2011-03-01

Most CBIR-based CAD systems (Content Based Image Retrieval systems for Computer Aided Diagnosis) identify lesions that are eventually relevant. These systems base their analysis upon a single independent view. This article presents a CBIR framework which automatically describes mammographic masses with the BI-RADS lexicon, fusing information from the two mammographic views. After an expert selects a Region of Interest (RoI) at the two views, a CBIR strategy searches similar masses in the database by automatically computing the Mahalanobis distance between shape and texture feature vectors of the mammography. The strategy was assessed in a set of 400 cases, for which the suggested descriptions were compared with the ground truth provided by the data base. Two information fusion strategies were evaluated, allowing a retrieval precision rate of 89.6% in the best scheme. Likewise, the best performance obtained for shape, margin and pathology description, using a ROC methodology, was reported as AUC = 0.86, AUC = 0.72 and AUC = 0.85, respectively.

The Role of Tool and Teacher Mediations in the Construction of Meanings for Reflection

ERIC Educational Resources Information Center

Healy, Lulu

2004-01-01

This article reports on a study aiming to design learning systems in which students' knowledge of reflection is brought closer to institutional knowledge of this isometry and to compare how their activities shape and are shaped by different forms of mediation. It presents descriptions of interactions of groups of students (aged 12-13 years) with…

Thermomechanical Modeling of Shape Memory Alloys and Applications

NASA Astrophysics Data System (ADS)

Lexcellent, C.; Leclercq, S.

The aim of the present paper is a general macroscopic description of the thermomechanical behavior of shape memory alloys (SMA). We use for framework the thermodynamics of irreversible processes. This model is efficient for describing the behavior of "smart" structures as a bronchial, a tentacle element and an prosthesis hybrid structure made of Ti Ni SMA wires embedded in a resin epoxy matrix.

Al-rich objects in ordinary chondrites - Related origin of carbonaceous and ordinary chondrites and their constituents

NASA Technical Reports Server (NTRS)

Bischoff, A.; Keil, K.

1984-01-01

A description is given of 169 Al-rich objects (arbitrarily defined as having 10 wt pct or more of Al2O3) from 24 ordinary chondrites of types 3 and 4, five regolith breccias containing unequilibrated material, the unique meteorite Kakangari, and a few ordinary chondrites of types 5 and 6. On the basis of shape and texture, the Al-rich objects are divided into chondrules (round, with igneous textures), irregularly shaped inclusions (similar to type F and spinel-rich complex Ca-Al-rich inclusions), and fragments (probably fragments of Al-rich chondrules and inclusions). For descriptive purposes, the Al-rich chondrules are further subdivided into compositional subgroups, although they are entirely transitional.

A survey of visual preprocessing and shape representation techniques

NASA Technical Reports Server (NTRS)

Olshausen, Bruno A.

1988-01-01

Many recent theories and methods proposed for visual preprocessing and shape representation are summarized. The survey brings together research from the fields of biology, psychology, computer science, electrical engineering, and most recently, neural networks. It was motivated by the need to preprocess images for a sparse distributed memory (SDM), but the techniques presented may also prove useful for applying other associative memories to visual pattern recognition. The material of this survey is divided into three sections: an overview of biological visual processing; methods of preprocessing (extracting parts of shape, texture, motion, and depth); and shape representation and recognition (form invariance, primitives and structural descriptions, and theories of attention).

Toward a metric for patterned injury analysis

NASA Astrophysics Data System (ADS)

Oliver, William R.; Fritsch, Daniel S.

1997-02-01

An intriguing question in the matching of objects with patterned injures in two and three dimensions is that of an appropriate metric for closeness -- is it possible to objectively measure how well an object 'fits' a patterned injury. Many investigators have suggested an energy-based metric, and have used such metrics to analyze craniofacial growth and anatomic variation. A strict dependence on homology is the primary disadvantage of this energy functional for generalized biological structures; many shapes do not have obvious landmarks. Some tentative solutions to the problem of landmark dependency for patterned injury analysis are presented. One intriguing approach comes from recent work in axiomatic vision. This approach has resulted in the development of a multiresolution medial axis for the extraction of shape primitives which can be used as the basis for registration. A scale-based description of this process can be captured in structures called cores, which can describe object shape and position in a highly compact manner. Cores may provide a scale- and shape-based method of determining correspondences necessary for determining the number and position of landmarks for some patterned injuries. Each of the approaches described are generalizable to higher dimensions, and can thus be used to analyze both two- and three- dimensional data. Together, they may represent a reasonable way of measuring shape distance for the purpose of matching objects and wounds, and can be combined with texture measures for a complete description.

The shape parameter and its modification for defining coastal profiles

NASA Astrophysics Data System (ADS)

Türker, Umut; Kabdaşli, M. Sedat

2009-03-01

The shape parameter is important for the theoretical description of the sandy coastal profiles. This parameter has previously been defined as a function of the sediment-settling velocity. However, the settling velocity cannot be characterized over a wide range of sediment grains. This, in turn, limits the calculation of the shape parameter over a wide range. This paper provides a simpler and faster analytical equation to describe the shape parameter. The validity of the equation has been tested and compared with the previously estimated values given in both graphical and tabular forms. The results of this study indicate that the analytical solutions of the shape parameter improved the usability of profile better than graphical solutions, predicting better results both at the surf zone and offshore.

Dynamical description of the fission process using the TD-BCS theory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Scamps, Guillaume, E-mail: scamps@nucl.phys.tohoku.ac.jp; Simenel, Cédric; Lacroix, Denis

2015-10-15

The description of fission remains a challenge for nuclear microscopic theories. The time-dependent Hartree-Fock approach with BCS pairing is applied to study the last stage of the fission process. A good agreement is found for the one-body observables: the total kinetic energy and the average mass asymmetry. The non-physical dependence of two-body observables with the initial shape is discussed.

Prospects of photonic nanojets for precise exposure on microobjects

DOE Office of Scientific and Technical Information (OSTI.GOV)

Geints, Yu. E., E-mail: ygeints@iao.ru; Zuev Institute of Atmospheric Optics, SB Russian Academy of Sciences, Acad. Zuev Square 1, Tomsk, 634021; Panina, E. K., E-mail: pek@iao.ru

We report on the new optical tool for precise manipulation of various microobjects. This tool is referred to as a “photonic nanojet” (PJ) and corresponds to specific spatially localized and high-intensity area formed near micron-sized transparent spherical dielectric particles illuminated by a visible laser radiation The descriptive analysis of the morphological shapes of photonic nanojets is presented. The PJ shape characterization is based on the numerical calculations of the near-field distribution according to the Mie theory and accounts for jet dimensions and shape complexity.

Ge growth on vicinal si(001) surfaces: island's shape and pair interaction versus miscut angle.

PubMed

Persichetti, L; Sgarlata, A; Fanfoni, M; Balzarotti, A

2011-10-01

A complete description of Ge growth on vicinal Si(001) surfaces is provided. The distinctive mechanisms of the epitaxial growth process on vicinal surfaces are clarified from the very early stages of Ge deposition to the nucleation of 3D islands. By interpolating high-resolution scanning tunneling microscopy measurements with continuum elasticity modeling, we assess the dependence of island's shape and elastic interaction on the substrate misorientation. Our results confirm that vicinal surfaces offer an additional degree of control over the shape and symmetry of self-assembled nanostructures.

Manifold Learning for 3D Shape Description and Classification

DTIC Science & Technology

2014-06-09

sportswear, personal protection clothing and equipment, office and health care device, etc. Therefore it is desirable to develop an effective shape...Modeling Figure 2: Toy example for submanifold decomposition. (a) The original data on the top are fused by two uncorrelated manifolds, blue and red... developed which is effective to extract two linear submanifolds. We demonstrated that comparing with existing manifold learning methods that only

Profile of Secondary School Students with High Mathematics Ability in Solving Shape and Space Problem

ERIC Educational Resources Information Center

Putra, Mulia; Novita, Rita

2015-01-01

This study aimed to describe the profile of secondary school students with high mathematics ability in solving shape and space problem in PISA (Program for International Student Assessment). It is a descriptive research with a qualitative approach, in which the subjects in this study were students of class VIII SMP N 1 Banda Aceh. The results show…

AN ENVIRONMENTAL TECHNOLOGY VERIFICATION (ETV) TESTING OF TWO NUTRIENT ANALYZERS AT AN INDUSTRIAL PLANT: SCHIMADZU SCIENTIFIC INSTRUMENTS, INC. TNPC-4110(C) AND A ZAPS TECHNOLOGIES, INC. MULTI-PARAMETER (MP-1)

EPA Science Inventory

The Environmental Technology Verification (ETV) Program, beginning as an initiative of the U.S. Environmental Protection Agency (EPA) in 1995, verifies the performance of commercially available, innovative technologies that can be used to measure environmental quality. The ETV p...

An Integrated Environment Monitoring System for Underground Coal Mines—Wireless Sensor Network Subsystem with Multi-Parameter Monitoring

PubMed Central

Zhang, Yu; Yang, Wei; Han, Dongsheng; Kim, Young-Il

2014-01-01

Environment monitoring is important for the safety of underground coal mine production, and it is also an important application of Wireless Sensor Networks (WSNs). We put forward an integrated environment monitoring system for underground coal mine, which uses the existing Cable Monitoring System (CMS) as the main body and the WSN with multi-parameter monitoring as the supplementary technique. As CMS techniques are mature, this paper mainly focuses on the WSN and the interconnection between the WSN and the CMS. In order to implement the WSN for underground coal mines, two work modes are designed: periodic inspection and interrupt service; the relevant supporting technologies, such as routing mechanism, collision avoidance, data aggregation, interconnection with the CMS, etc., are proposed and analyzed. As WSN nodes are limited in energy supply, calculation and processing power, an integrated network management scheme is designed in four aspects, i.e., topology management, location management, energy management and fault management. Experiments were carried out both in a laboratory and in a real underground coal mine. The test results indicate that the proposed integrated environment monitoring system for underground coal mines is feasible and all designs performed well as expected. PMID:25051037

Multiparameter flow cytometric analysis of a pH sensitive formyl peptide with application to receptor structure and processing kinetics

DOE Office of Scientific and Technical Information (OSTI.GOV)

Fay, S.P.; Domalewski, M.D.; Houghton, T.G.

1994-02-01

Environmentally sensitive molecules have many potential cellular applications. The authors have investigated the utility of a pH sensitive ligand for the formyl peptide receptor, CHO-Met-Leu-Phe-Phe-Lys (SNAFL)-OH (SNAFL-seminaphthofluorescein), because in previous studies protonation has been used to explain the quenching when the fluorescinated formyl pentapeptide ligand binds to this receptor. Moreover, acidification in intracellular compartments is a general mechanism occurring in cells during processing of ligand-receptor complexes. Because the protonated form of SNAFL is excited at 488 nm with emission at 530 nm and the unprotonated form is excited at 568 nm with emission at 650 nm, the ratio of protonatedmore » and unprotonated forms can be examined by multiparameter flow cytometry. The authors found that the receptor-bound ligand is sensitive to both the extracellular and intracellular pH. There is a small increase in the pK[sub a] of the ligand upon binding to the receptor consistent with protonation in the binding pocket. Once internalized, spectral changes in the probe consistent with acidification and ligand dissociation from the receptor are observed. 22 refs., 4 figs.« less

Real-Time Monitoring of Singlet Oxygen and Oxygen Partial Pressure During the Deep Photodynamic Therapy In Vitro.

PubMed

Li, Weitao; Huang, Dong; Zhang, Yan; Liu, Yangyang; Gu, Yueqing; Qian, Zhiyu

2016-09-01

Photodynamic therapy (PDT) is an effective noninvasive method for the tumor treatment. The major challenge in current PDT research is how to quantitatively evaluate therapy effects. To our best knowledge, this is the first time to combine multi-parameter detection methods in PDT. More specifically, we have developed a set of system, including the high-sensitivity measurement of singlet oxygen, oxygen partial pressure and fluorescence image. In this paper, the detection ability of the system was validated by the different concentrations of carbon quantum dots. Moreover, the correlation between singlet oxygen and oxygen partial pressure with laser irradiation was observed. Then, the system could detect the signal up to 0.5 cm tissue depth with 660 nm irradiation and 1 cm tissue depth with 980 nm irradiation by using up-conversion nanoparticles during PDT in vitro. Furthermore, we obtained the relationship among concentration of singlet oxygen, oxygen partial pressure and tumor cell viability under certain conditions. The results indicate that the multi-parameter detection system is a promising asset to evaluate the deep tumor therapy during PDT. Moreover, the system might be potentially used for the further study in biology and molecular imaging.

Development of motion resistant instrumentation for ambulatory near-infrared spectroscopy

PubMed Central

Zhang, Quan; Yan, Xiangguo; Strangman, Gary E.

2011-01-01

Ambulatory near-infrared spectroscopy (aNIRS) enables recording of systemic or tissue-specific hemodynamics and oxygenation during a person's normal activities. It has particular potential for the diagnosis and management of health problems with unpredictable and transient hemodynamic symptoms, or medical conditions requiring continuous, long-duration monitoring. aNIRS is also needed in conditions where regular monitoring or imaging cannot be applied, including remote environments such as during spaceflight or at high altitude. One key to the successful application of aNIRS is reducing the impact of motion artifacts in aNIRS recordings. In this paper, we describe the development of a novel prototype aNIRS monitor, called NINscan, and our efforts to reduce motion artifacts in aNIRS monitoring. Powered by 2 AA size batteries and weighting 350 g, NINscan records NIRS, ECG, respiration, and acceleration for up to 14 h at a 250 Hz sampling rate. The system's performance and resistance to motion is demonstrated by long term quantitative phantom tests, Valsalva maneuver tests, and multiparameter monitoring during parabolic flight and high altitude hiking. To the best of our knowledge, this is the first report of multiparameter aNIRS monitoring and its application in parabolic flight. PMID:21895335

A highly precise frequency-based method for estimating the tension of an inclined cable with unknown boundary conditions

NASA Astrophysics Data System (ADS)

Ma, Lin

2017-11-01

This paper develops a method for precisely determining the tension of an inclined cable with unknown boundary conditions. First, the nonlinear motion equation of an inclined cable is derived, and a numerical model of the motion of the cable is proposed using the finite difference method. The proposed numerical model includes the sag-extensibility, flexural stiffness, inclination angle and rotational stiffness at two ends of the cable. Second, the influence of the dynamic parameters of the cable on its frequencies is discussed in detail, and a method for precisely determining the tension of an inclined cable is proposed based on the derivatives of the eigenvalues of the matrices. Finally, a multiparameter identification method is developed that can simultaneously identify multiple parameters, including the rotational stiffness at two ends. This scheme is applicable to inclined cables with varying sag, varying flexural stiffness and unknown boundary conditions. Numerical examples indicate that the method provides good precision. Because the parameters of cables other than tension (e.g., the flexural stiffness and rotational stiffness at the ends) are not accurately known in practical engineering, the multiparameter identification method could further improve the accuracy of cable tension measurements.

Multi-Response Parameter Interval Sensitivity and Optimization for the Composite Tape Winding Process.

PubMed

Deng, Bo; Shi, Yaoyao; Yu, Tao; Kang, Chao; Zhao, Pan

2018-01-31

The composite tape winding process, which utilizes a tape winding machine and prepreg tapes, provides a promising way to improve the quality of composite products. Nevertheless, the process parameters of composite tape winding have crucial effects on the tensile strength and void content, which are closely related to the performances of the winding products. In this article, two different object values of winding products, including mechanical performance (tensile strength) and a physical property (void content), were respectively calculated. Thereafter, the paper presents an integrated methodology by combining multi-parameter relative sensitivity analysis and single-parameter sensitivity analysis to obtain the optimal intervals of the composite tape winding process. First, the global multi-parameter sensitivity analysis method was applied to investigate the sensitivity of each parameter in the tape winding processing. Then, the local single-parameter sensitivity analysis method was employed to calculate the sensitivity of a single parameter within the corresponding range. Finally, the stability and instability ranges of each parameter were distinguished. Meanwhile, the authors optimized the process parameter ranges and provided comprehensive optimized intervals of the winding parameters. The verification test validated that the optimized intervals of the process parameters were reliable and stable for winding products manufacturing.

Novel Serial Positive Enrichment Technology Enables Clinical Multiparameter Cell Sorting

PubMed Central

Tschulik, Claudia; Piossek, Christine; Bet, Jeannette; Yamamoto, Tori N.; Schiemann, Matthias; Neuenhahn, Michael; Martin, Klaus; Schlapschy, Martin; Skerra, Arne; Schmidt, Thomas; Edinger, Matthias; Riddell, Stanley R.; Germeroth, Lothar; Busch, Dirk H.

2012-01-01

A general obstacle for clinical cell preparations is limited purity, which causes variability in the quality and potency of cell products and might be responsible for negative side effects due to unwanted contaminants. Highly pure populations can be obtained best using positive selection techniques. However, in many cases target cell populations need to be segregated from other cells by combinations of multiple markers, which is still difficult to achieve – especially for clinical cell products. Therefore, we have generated low-affinity antibody-derived Fab-fragments, which stain like parental antibodies when multimerized via Strep-tag and Strep-Tactin, but can subsequently be removed entirely from the target cell population. Such reagents can be generated for virtually any antigen and can be used for sequential positive enrichment steps via paramagnetic beads. First protocols for multiparameter enrichment of two clinically relevant cell populations, CD4high/CD25high/CD45RAhigh ‘regulatory T cells’ and CD8high/CD62Lhigh/CD45RAneg ‘central memory T cells’, have been established to determine quality and efficacy parameters of this novel technology, which should have broad applicability for clinical cell sorting as well as basic research. PMID:22545138

Multi-Response Parameter Interval Sensitivity and Optimization for the Composite Tape Winding Process

PubMed Central

Yu, Tao; Kang, Chao; Zhao, Pan

2018-01-01

The composite tape winding process, which utilizes a tape winding machine and prepreg tapes, provides a promising way to improve the quality of composite products. Nevertheless, the process parameters of composite tape winding have crucial effects on the tensile strength and void content, which are closely related to the performances of the winding products. In this article, two different object values of winding products, including mechanical performance (tensile strength) and a physical property (void content), were respectively calculated. Thereafter, the paper presents an integrated methodology by combining multi-parameter relative sensitivity analysis and single-parameter sensitivity analysis to obtain the optimal intervals of the composite tape winding process. First, the global multi-parameter sensitivity analysis method was applied to investigate the sensitivity of each parameter in the tape winding processing. Then, the local single-parameter sensitivity analysis method was employed to calculate the sensitivity of a single parameter within the corresponding range. Finally, the stability and instability ranges of each parameter were distinguished. Meanwhile, the authors optimized the process parameter ranges and provided comprehensive optimized intervals of the winding parameters. The verification test validated that the optimized intervals of the process parameters were reliable and stable for winding products manufacturing. PMID:29385048

High speed acquisition of multiparameter data using a Macintosh IIcx

NASA Astrophysics Data System (ADS)

Berno, Anthony; Vogel, John S.; Caffee, Marc

1991-05-01

Accelerator mass spectrometry systems based on > 3 MV tandem accelerators often use multianode ionization detectors and/or time-of-flight detectors to identify individual isotopes through multiparameter analysis. A Macintosh IIcx has been programmed to collect AMS data from a CAMAC-implemented analyzer and to display the histogrammed individual parameters and a doubleparameter array. The computer-CAMAC connection is through a NuBus to CAMAC dataway interface which allows direct addressing to all functions and registers in the crate. Asynchronous data from the rare isotope are sorted into a CAMAC memory module by a list sequence controller. Isotope switching is controlled by a one-cycle timing generator. A rate-dependent amount of time is used to transfer the data from the memory module at the end of each timing cycle. The present configuration uses 10-75 ms for rates of 500-10000 cps. Parameter analysis occurs during the rest of the 520 ms data collection cycle. Completed measurements of the isotope concentrations of each sample are written to files which are compatible with standard Macintosh databases or other processing programs. The system is inexpensive and operates at speeds comparable to those obtainable using larger computers.

An integrated environment monitoring system for underground coal mines--Wireless Sensor Network subsystem with multi-parameter monitoring.

PubMed

Zhang, Yu; Yang, Wei; Han, Dongsheng; Kim, Young-Il

2014-07-21

Environment monitoring is important for the safety of underground coal mine production, and it is also an important application of Wireless Sensor Networks (WSNs). We put forward an integrated environment monitoring system for underground coal mine, which uses the existing Cable Monitoring System (CMS) as the main body and the WSN with multi-parameter monitoring as the supplementary technique. As CMS techniques are mature, this paper mainly focuses on the WSN and the interconnection between the WSN and the CMS. In order to implement the WSN for underground coal mines, two work modes are designed: periodic inspection and interrupt service; the relevant supporting technologies, such as routing mechanism, collision avoidance, data aggregation, interconnection with the CMS, etc., are proposed and analyzed. As WSN nodes are limited in energy supply, calculation and processing power, an integrated network management scheme is designed in four aspects, i.e., topology management, location management, energy management and fault management. Experiments were carried out both in a laboratory and in a real underground coal mine. The test results indicate that the proposed integrated environment monitoring system for underground coal mines is feasible and all designs performed well as expected.

Description of textures by a structural analysis.

PubMed

Tomita, F; Shirai, Y; Tsuji, S

1982-02-01

A structural analysis system for describing natural textures is introduced. The analyzer automatically extracts the texture elements in an input image, measures their properties, classifies them into some distinctive classes (one ``ground'' class and some ``figure'' classes), and computes the distributions of the gray level, the shape, and the placement of the texture elements in each class. These descriptions are used for classification of texture images. An analysis-by-synthesis method for evaluating texture analyzers is also presented. We propose a synthesizer which generates a texture image based on the descriptions. By comparing the reconstructed image with the original one, we can see what information is preserved and what is lost in the descriptions.

Shape, form, function and Leishmania pathogenicity: from textbook descriptions to biological understanding

PubMed Central

Gull, Keith

2017-01-01

The shape and form of protozoan parasites are inextricably linked to their pathogenicity. The evolutionary pressure associated with establishing and maintaining an infection and transmission to vector or host has shaped parasite morphology. However, there is not a ‘one size fits all’ morphological solution to these different pressures, and parasites exhibit a range of different morphologies, reflecting the diversity of their complex life cycles. In this review, we will focus on the shape and form of Leishmania spp., a group of very successful protozoan parasites that cause a range of diseases from self-healing cutaneous leishmaniasis to visceral leishmaniasis, which is fatal if left untreated. PMID:28903998

Primal-dual methods of shape sensitivity analysis for curvilinear cracks with nonpenetration

NASA Astrophysics Data System (ADS)

Kovtunenko, V. A.

2006-10-01

Based on a level-set description of a crack moving with a given velocity, the problem of shape perturb-ation of the crack is considered. Nonpenetration conditions are imposed between opposite crack surfaces which result in a constrained minimization problem describing equilibrium of a solid with the crack. We suggest a minimax formulation of the state problem thus allowing curvilinear (nonplanar) cracks for the consideration. Utilizing primal-dual methods of shape sensitivity analysis we obtain the general formula for a shape derivative of the potential energy, which describes an energy-release rate for the curvilinear cracks. The conditions sufficient to rewrite it in the form of a path-independent integral (J-integral) are derived.

Eyeglasses Lens Contour Extraction from Facial Images Using an Efficient Shape Description

PubMed Central

Borza, Diana; Darabant, Adrian Sergiu; Danescu, Radu

2013-01-01

This paper presents a system that automatically extracts the position of the eyeglasses and the accurate shape and size of the frame lenses in facial images. The novelty brought by this paper consists in three key contributions. The first one is an original model for representing the shape of the eyeglasses lens, using Fourier descriptors. The second one is a method for generating the search space starting from a finite, relatively small number of representative lens shapes based on Fourier morphing. Finally, we propose an accurate lens contour extraction algorithm using a multi-stage Monte Carlo sampling technique. Multiple experiments demonstrate the effectiveness of our approach. PMID:24152926

Depicting 3D shape using lines

NASA Astrophysics Data System (ADS)

DeCarlo, Doug

2012-03-01

Over the last few years, researchers in computer graphics have developed sophisticated mathematical descriptions of lines on 3D shapes that can be rendered convincingly as strokes in drawings. These innovations highlight fundamental questions about how human perception takes strokes in drawings as evidence of 3D structure. Answering these questions will lead to a greater scientific understanding of the flexibility and richness of human perception, as well as to practical techniques for synthesizing clearer and more compelling drawings. This paper reviews what is known about the mathematics and perception of computer-generated line drawings of shape and motivates an ongoing program of research to better characterize the shapes people see when they look at such drawings.

Patch-Based Generative Shape Model and MDL Model Selection for Statistical Analysis of Archipelagos

NASA Astrophysics Data System (ADS)

Ganz, Melanie; Nielsen, Mads; Brandt, Sami

We propose a statistical generative shape model for archipelago-like structures. These kind of structures occur, for instance, in medical images, where our intention is to model the appearance and shapes of calcifications in x-ray radio graphs. The generative model is constructed by (1) learning a patch-based dictionary for possible shapes, (2) building up a time-homogeneous Markov model to model the neighbourhood correlations between the patches, and (3) automatic selection of the model complexity by the minimum description length principle. The generative shape model is proposed as a probability distribution of a binary image where the model is intended to facilitate sequential simulation. Our results show that a relatively simple model is able to generate structures visually similar to calcifications. Furthermore, we used the shape model as a shape prior in the statistical segmentation of calcifications, where the area overlap with the ground truth shapes improved significantly compared to the case where the prior was not used.

Preshaping command inputs to reduce telerobotic system oscillations

NASA Technical Reports Server (NTRS)

Singer, Neil C.; Seering, Warren P.

1989-01-01

The results of using a new technique for shaping inputs to a model of the space shuttle Remote Manipulator System (RMS) are presented. The shapes inputs move the system to the same location that was originally commanded, however, the oscillations of the machine are considerably reduced. An overview of the new shaping method is presented. A description of RMS model is provided. The problem of slow joint servo rates on the RMS is accommodated with an extension of the shaping method. The results and sample data are also presented for both joint and three-dimensional cartesian motions. The results demonstrate that the new shaping method performs well on large, telerobotic systems which exhibit significant structural vibration. The new method is shown to also result in considerable energy savings during operations of the RMS manipulator.

Benchmarking of HPCC: A novel 3D molecular representation combining shape and pharmacophoric descriptors for efficient molecular similarity assessments.

PubMed

Karaboga, Arnaud S; Petronin, Florent; Marchetti, Gino; Souchet, Michel; Maigret, Bernard

2013-04-01

Since 3D molecular shape is an important determinant of biological activity, designing accurate 3D molecular representations is still of high interest. Several chemoinformatic approaches have been developed to try to describe accurate molecular shapes. Here, we present a novel 3D molecular description, namely harmonic pharma chemistry coefficient (HPCC), combining a ligand-centric pharmacophoric description projected onto a spherical harmonic based shape of a ligand. The performance of HPCC was evaluated by comparison to the standard ROCS software in a ligand-based virtual screening (VS) approach using the publicly available directory of useful decoys (DUD) data set comprising over 100,000 compounds distributed across 40 protein targets. Our results were analyzed using commonly reported statistics such as the area under the curve (AUC) and normalized sum of logarithms of ranks (NSLR) metrics. Overall, our HPCC 3D method is globally as efficient as the state-of-the-art ROCS software in terms of enrichment and slightly better for more than half of the DUD targets. Since it is largely admitted that VS results depend strongly on the nature of the protein families, we believe that the present HPCC solution is of interest over the current ligand-based VS methods. Copyright © 2013 Elsevier Inc. All rights reserved.

Quantification of the Spatial Organization of the Nuclear Lamina as a Tool for Cell Classification

PubMed Central

Righolt, Christiaan H.; Zatreanu, Diana A.; Raz, Vered

2013-01-01

The nuclear lamina is the structural scaffold of the nuclear envelope that plays multiple regulatory roles in chromatin organization and gene expression as well as a structural role in nuclear stability. The lamina proteins, also referred to as lamins, determine nuclear lamina organization and define the nuclear shape and the structural integrity of the cell nucleus. In addition, lamins are connected with both nuclear and cytoplasmic structures forming a dynamic cellular structure whose shape changes upon external and internal signals. When bound to the nuclear lamina, the lamins are mobile, have an impact on the nuclear envelop structure, and may induce changes in their regulatory functions. Changes in the nuclear lamina shape cause changes in cellular functions. A quantitative description of these structural changes could provide an unbiased description of changes in cellular function. In this review, we describe how changes in the nuclear lamina can be measured from three-dimensional images of lamins at the nuclear envelope, and we discuss how structural changes of the nuclear lamina can be used for cell classification. PMID:27335676

Quantification of the Spatial Organization of the Nuclear Lamina as a Tool for Cell Classification.

PubMed

Righolt, Christiaan H; Zatreanu, Diana A; Raz, Vered

2013-01-01

The nuclear lamina is the structural scaffold of the nuclear envelope that plays multiple regulatory roles in chromatin organization and gene expression as well as a structural role in nuclear stability. The lamina proteins, also referred to as lamins, determine nuclear lamina organization and define the nuclear shape and the structural integrity of the cell nucleus. In addition, lamins are connected with both nuclear and cytoplasmic structures forming a dynamic cellular structure whose shape changes upon external and internal signals. When bound to the nuclear lamina, the lamins are mobile, have an impact on the nuclear envelop structure, and may induce changes in their regulatory functions. Changes in the nuclear lamina shape cause changes in cellular functions. A quantitative description of these structural changes could provide an unbiased description of changes in cellular function. In this review, we describe how changes in the nuclear lamina can be measured from three-dimensional images of lamins at the nuclear envelope, and we discuss how structural changes of the nuclear lamina can be used for cell classification.

Postdoctoral Fellow | Center for Cancer Research

Cancer.gov

The positions will provide excellent training opportunities in mucosal immunology.  The ideal candidates must be able to work independently and have demonstrated abilities in clear scientific project planning and reporting.  Experience in multiparameter flow cytometry, gene expression analysis, intestinal cell isolation, and mouse models of disease is desirable.  One position will be preferentially given to candidate with experience in non-human primate models.  

A general power equation for predicting bed load transport rates in gravel bed rivers

Treesearch

Jeffrey J. Barry; John M. Buffington; John G. King

2004-01-01

A variety of formulae has been developed to predict bed load transport in gravel bed rivers, ranging from simple regressions to complex multiparameter formulations. The ability to test these formulae across numerous field sites has, until recently, been hampered by a paucity of bed load transport data for gravel bed rivers. We use 2104 bed load transport observations...

Updating Parameters for Volcanic Hazard Assessment Using Multi-parameter Monitoring Data Streams And Bayesian Belief Networks

NASA Astrophysics Data System (ADS)

Odbert, Henry; Aspinall, Willy

2014-05-01

Evidence-based hazard assessment at volcanoes assimilates knowledge about the physical processes of hazardous phenomena and observations that indicate the current state of a volcano. Incorporating both these lines of evidence can inform our belief about the likelihood (probability) and consequences (impact) of possible hazardous scenarios, forming a basis for formal quantitative hazard assessment. However, such evidence is often uncertain, indirect or incomplete. Approaches to volcano monitoring have advanced substantially in recent decades, increasing the variety and resolution of multi-parameter timeseries data recorded at volcanoes. Interpreting these multiple strands of parallel, partial evidence thus becomes increasingly complex. In practice, interpreting many timeseries requires an individual to be familiar with the idiosyncrasies of the volcano, monitoring techniques, configuration of recording instruments, observations from other datasets, and so on. In making such interpretations, an individual must consider how different volcanic processes may manifest as measureable observations, and then infer from the available data what can or cannot be deduced about those processes. We examine how parts of this process may be synthesised algorithmically using Bayesian inference. Bayesian Belief Networks (BBNs) use probability theory to treat and evaluate uncertainties in a rational and auditable scientific manner, but only to the extent warranted by the strength of the available evidence. The concept is a suitable framework for marshalling multiple strands of evidence (e.g. observations, model results and interpretations) and their associated uncertainties in a methodical manner. BBNs are usually implemented in graphical form and could be developed as a tool for near real-time, ongoing use in a volcano observatory, for example. We explore the application of BBNs in analysing volcanic data from the long-lived eruption at Soufriere Hills Volcano, Montserrat. We discuss the uncertainty of inferences, and how our method provides a route to formal propagation of uncertainties in hazard models. Such approaches provide an attractive route to developing an interface between volcano monitoring analyses and probabilistic hazard scenario analysis. We discuss the use of BBNs in hazard analysis as a tractable and traceable tool for fast, rational assimilation of complex, multi-parameter data sets in the context of timely volcanic crisis decision support.

Structural and functional screening in human induced-pluripotent stem cell-derived cardiomyocytes accurately identifies cardiotoxicity of multiple drug types

DOE Office of Scientific and Technical Information (OSTI.GOV)

Doherty, Kimberly R., E-mail: kimberly.doherty@quintiles.com; Talbert, Dominique R.; Trusk, Patricia B.

Safety pharmacology studies that evaluate new drug entities for potential cardiac liability remain a critical component of drug development. Current studies have shown that in vitro tests utilizing human induced pluripotent stem cell-derived cardiomyocytes (hiPS-CM) may be beneficial for preclinical risk evaluation. We recently demonstrated that an in vitro multi-parameter test panel assessing overall cardiac health and function could accurately reflect the associated clinical cardiotoxicity of 4 FDA-approved targeted oncology agents using hiPS-CM. The present studies expand upon this initial observation to assess whether this in vitro screen could detect cardiotoxicity across multiple drug classes with known clinical cardiac risks.more » Thus, 24 drugs were examined for their effect on both structural (viability, reactive oxygen species generation, lipid formation, troponin secretion) and functional (beating activity) endpoints in hiPS-CM. Using this screen, the cardiac-safe drugs showed no effects on any of the tests in our panel. However, 16 of 18 compounds with known clinical cardiac risk showed drug-induced changes in hiPS-CM by at least one method. Moreover, when taking into account the Cmax values, these 16 compounds could be further classified depending on whether the effects were structural, functional, or both. Overall, the most sensitive test assessed cardiac beating using the xCELLigence platform (88.9%) while the structural endpoints provided additional insight into the mechanism of cardiotoxicity for several drugs. These studies show that a multi-parameter approach examining both cardiac cell health and function in hiPS-CM provides a comprehensive and robust assessment that can aid in the determination of potential cardiac liability. - Highlights: • 24 drugs were tested for cardiac liability using an in vitro multi-parameter screen. • Changes in beating activity were the most sensitive in predicting cardiac risk. • Structural effects add in-depth insight towards mechanism of cardiac toxicity. • Testing functional and structural endpoints enhances early cardiac risk assessment.« less

Embedded Active Fiber Optic Sensing Network for Structural Health Monitoring in Harsh Environments

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Anbo

This report summarizes technical progress on the program “Embedded Active Fiber Optic Sensing Network for Structural Health Monitoring in Harsh Environments” funded by the National Energy Technology Laboratory of the U.S. Department of Energy, and performed by the Center for Photonics Technology at Virginia Tech. The objective of this project is to develop a first-of-a-kind technology for remote fiber optic generation and detection of acoustic waves for structural health monitoring in harsh environments. During the project period, which is from April 1, 2013 to Septemeber 30, 2016, three different acoustic generation mechanisms were studied in detail for their applications inmore » building a fiber optic acoustic generation unit (AGU), including laser induced plasma breakdown (LIP), Erbium-doped fiber laser absorption, and metal laser absorption. By comparing the performance of the AGUs designed based on these three mechanisms and analyzing the experimental results with simulations, the metal laser absorption method was selected to build a complete fiber optic structure health monitoring (FO-SHM) system for the proposed high temperature multi-parameter structure health monitoring application. Based on the simulation of elastic wave propagation and fiber Bragg grating acoustic pulse detection, an FO-SHM element together with a completed interrogation system were designed and built. This system was first tested on an aluminum piece in the low-temperature range and successfully demonstrated its capability of multi-parameter monitoring and multi-point sensing. In the later stages of the project, the research was focused on improving the surface attachment design and preparing the FO-SHM element for high temperature environment tests. After several upgrades to the surface attachment methods, the FO-SHM element was able to work reliably up to 600oC when attached to P91 pipes, which are the target material of this project. In the final stage of this project, this FO-SHM sensing system was tested in the simulated harsh environment for its multi-parameter monitoring performance and high-temperature survivability.« less

Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Doherty, Kimberly R., E-mail: kimberly.doherty@quintiles.com; Wappel, Robert L.; Talbert, Dominique R.

2013-10-01

Tyrosine kinase inhibitors (TKi) have greatly improved the treatment and prognosis of multiple cancer types. However, unexpected cardiotoxicity has arisen in a subset of patients treated with these agents that was not wholly predicted by pre-clinical testing, which centers around animal toxicity studies and inhibition of the human Ether-à-go-go-Related Gene (hERG) channel. Therefore, we sought to determine whether a multi-parameter test panel assessing the effect of drug treatment on cellular, molecular, and electrophysiological endpoints could accurately predict cardiotoxicity. We examined how 4 FDA-approved TKi agents impacted cell viability, apoptosis, reactive oxygen species (ROS) generation, metabolic status, impedance, and ion channelmore » function in human cardiomyocytes. The 3 drugs clinically associated with severe cardiac adverse events (crizotinib, sunitinib, nilotinib) all proved to be cardiotoxic in our in vitro tests while the relatively cardiac-safe drug erlotinib showed only minor changes in cardiac cell health. Crizotinib, an ALK/MET inhibitor, led to increased ROS production, caspase activation, cholesterol accumulation, disruption in cardiac cell beat rate, and blockage of ion channels. The multi-targeted TKi sunitinib showed decreased cardiomyocyte viability, AMPK inhibition, increased lipid accumulation, disrupted beat pattern, and hERG block. Nilotinib, a second generation Bcr-Abl inhibitor, led to increased ROS generation, caspase activation, hERG block, and an arrhythmic beat pattern. Thus, each drug showed a unique toxicity profile that may reflect the multiple mechanisms leading to cardiotoxicity. This study demonstrates that a multi-parameter approach can provide a robust characterization of drug-induced cardiomyocyte damage that can be leveraged to improve drug safety during early phase development. - Highlights: • TKi with known adverse effects show unique cardiotoxicity profiles in this panel. • Crizotinib increases ROS, apoptosis, and cholesterol as well as alters beat rate. • Sunitinib inhibits AMPK, increases lipids and alters the cardiac beat pattern. • Nilotinib causes ROS and caspase activation, decreased lipids and arrhythmia. • Erlotinib did not impact ROS, caspase, or lipid levels or affect the beat pattern.« less

Multi-Parameter GEOSCOPE Land Stations and Ocean Bottom Observatories

NASA Astrophysics Data System (ADS)

Stutzmann, E.; Roult, G.; Montagner, J.; Karczewski, J.; Geoscope Group,.

2002-12-01

Since the mid-eighties, the number of high quality broadband stations installed over the world has increased in a spectacular way and these stations cover now most of the emerged lands, with a higher concentration in the northern hemisphere between the latitudes 0 and 60N. The GEOSCOPE program has been the first global network of 3-component broadband seismic stations and has contributed to the elaboration of the FDSN. The 25 broadband GEOSCOPE stations fulfill the FDSN criteria, the data are stored in data-centers at the IPGP and IRIS DMC and are accessible through the netdc procedure (email to netdc@ipgp.jussieu.fr) or via the web. GEOSCOPE data have contributed to the major progresses of our knowledge of the earth interior. The earthquake CMT are now determined in a routine manner and the temporal history of the seismic source is accessible for the largest earthquakes. The geographical distribution of GEOSCOPE stations, specially in the southern hemisphere, has also played an important role in improving the resolution of global tomographic models. Recent P-wave models give high resolution images of subducted slabs whereas recent S-wave models have enable to discover the two super-swells. The evolution of the GEOSCOPE program is now focused on the installation of multi-parameter stations including 3-component broadband seismic sensors, pressure gauge, thermometer and GPS receivers. These stations will enable to decrease the seismic noise, and -among others- to better characterize the background free oscillations of the earth. The seismic station earth coverage is limited by the presence of oceans and the next step is the installation of ocean bottom broadband stations. For this purpose, in 1992, a first temporary station sismobs/OFM has been working for 2 weeks, along the mid atlantic ridge. In 1997, an international multi-parameter station, MOISE has been operating during 3 months in the Monterey Bay. The further step is the installation of the station NERO in a ODP hole along the Ninety East Ridge in collaboration with IFREMER and JAMSTEC. The location of this station has been decided by the ION program and the station will be operating for at least 2 years.

Quantitative ultrasound assessment of breast tumor response to chemotherapy using a multi-parameter approach

PubMed Central

Tadayyon, Hadi; Sannachi, Lakshmanan; Gangeh, Mehrdad; Sadeghi-Naini, Ali; Tran, William; Trudeau, Maureen E.; Pritchard, Kathleen; Ghandi, Sonal; Verma, Sunil; Czarnota, Gregory J.

2016-01-01

Purpose This study demonstrated the ability of quantitative ultrasound (QUS) parameters in providing an early prediction of tumor response to neoadjuvant chemotherapy (NAC) in patients with locally advanced breast cancer (LABC). Methods Using a 6-MHz array transducer, ultrasound radiofrequency (RF) data were collected from 58 LABC patients prior to NAC treatment and at weeks 1, 4, and 8 of their treatment, and prior to surgery. QUS parameters including midband fit (MBF), spectral slope (SS), spectral intercept (SI), spacing among scatterers (SAS), attenuation coefficient estimate (ACE), average scatterer diameter (ASD), and average acoustic concentration (AAC) were determined from the tumor region of interest. Ultrasound data were compared with the ultimate clinical and pathological response of the patient's tumor to treatment and patient recurrence-free survival. Results Multi-parameter discriminant analysis using the κ-nearest-neighbor classifier demonstrated that the best response classification could be achieved using the combination of MBF, SS, and SAS, with an accuracy of 60 ± 10% at week 1, 77 ± 8% at week 4 and 75 ± 6% at week 8. Furthermore, when the QUS measurements at each time (week) were combined with pre-treatment (week 0) QUS values, the classification accuracies improved (70 ± 9% at week 1, 80 ± 5% at week 4, and 81 ± 6% at week 8). Finally, the multi-parameter QUS model demonstrated a significant difference in survival rates of responding and non-responding patients at weeks 1 and 4 (p=0.035, and 0.027, respectively). Conclusion This study demonstrated for the first time, using new parameters tested on relatively large patient cohort and leave-one-out classifier evaluation, that a hybrid QUS biomarker including MBF, SS, and SAS could, with relatively high sensitivity and specificity, detect the response of LABC tumors to NAC as early as after 4 weeks of therapy. The findings of this study also suggested that incorporating pre-treatment QUS parameters of a tumor improved the classification results. This work demonstrated the potential of QUS and machine learning methods for the early assessment of breast tumor response to NAC and providing personalized medicine with regards to the treatment planning of refractory patients. PMID:27105515

Quantitative ultrasound assessment of breast tumor response to chemotherapy using a multi-parameter approach.

PubMed

Tadayyon, Hadi; Sannachi, Lakshmanan; Gangeh, Mehrdad; Sadeghi-Naini, Ali; Tran, William; Trudeau, Maureen E; Pritchard, Kathleen; Ghandi, Sonal; Verma, Sunil; Czarnota, Gregory J

2016-07-19

This study demonstrated the ability of quantitative ultrasound (QUS) parameters in providing an early prediction of tumor response to neoadjuvant chemotherapy (NAC) in patients with locally advanced breast cancer (LABC). Using a 6-MHz array transducer, ultrasound radiofrequency (RF) data were collected from 58 LABC patients prior to NAC treatment and at weeks 1, 4, and 8 of their treatment, and prior to surgery. QUS parameters including midband fit (MBF), spectral slope (SS), spectral intercept (SI), spacing among scatterers (SAS), attenuation coefficient estimate (ACE), average scatterer diameter (ASD), and average acoustic concentration (AAC) were determined from the tumor region of interest. Ultrasound data were compared with the ultimate clinical and pathological response of the patient's tumor to treatment and patient recurrence-free survival. Multi-parameter discriminant analysis using the κ-nearest-neighbor classifier demonstrated that the best response classification could be achieved using the combination of MBF, SS, and SAS, with an accuracy of 60 ± 10% at week 1, 77 ± 8% at week 4 and 75 ± 6% at week 8. Furthermore, when the QUS measurements at each time (week) were combined with pre-treatment (week 0) QUS values, the classification accuracies improved (70 ± 9% at week 1, 80 ± 5% at week 4, and 81 ± 6% at week 8). Finally, the multi-parameter QUS model demonstrated a significant difference in survival rates of responding and non-responding patients at weeks 1 and 4 (p=0.035, and 0.027, respectively). This study demonstrated for the first time, using new parameters tested on relatively large patient cohort and leave-one-out classifier evaluation, that a hybrid QUS biomarker including MBF, SS, and SAS could, with relatively high sensitivity and specificity, detect the response of LABC tumors to NAC as early as after 4 weeks of therapy. The findings of this study also suggested that incorporating pre-treatment QUS parameters of a tumor improved the classification results. This work demonstrated the potential of QUS and machine learning methods for the early assessment of breast tumor response to NAC and providing personalized medicine with regards to the treatment planning of refractory patients.

Prostate malignancy grading using gland-related shape descriptors

NASA Astrophysics Data System (ADS)

Braumann, Ulf-Dietrich; Scheibe, Patrick; Loeffler, Markus; Kristiansen, Glen; Wernert, Nicolas

2014-03-01

A proof-of-principle study was accomplished assessing the descriptive potential of two simple geometric measures (shape descriptors) applied to sets of segmented glands within images of 125 prostate cancer tissue sections. Respective measures addressing glandular shapes were (i) inverse solidity and (ii) inverse compactness. Using a classifier based on logistic regression, Gleason grades 3 and 4/5 could be differentiated with an accuracy of approx. 95%. Results suggest not only good discriminatory properties, but also robustness against gland segmentation variations. False classifications in part were caused by inadvertent Gleason grade assignments, as a-posteriori re-inspections had turned out.

Advanced Life Support System Value Metric

NASA Technical Reports Server (NTRS)

Jones, Harry W.; Rasky, Daniel J. (Technical Monitor)

1999-01-01

The NASA Advanced Life Support (ALS) Program is required to provide a performance metric to measure its progress in system development. Extensive discussions within the ALS program have led to the following approach. The Equivalent System Mass (ESM) metric has been traditionally used and provides a good summary of the weight, size, and power cost factors of space life support equipment. But ESM assumes that all the systems being traded off exactly meet a fixed performance requirement, so that the value and benefit (readiness, performance, safety, etc.) of all the different systems designs are considered to be exactly equal. This is too simplistic. Actual system design concepts are selected using many cost and benefit factors and the system specification is defined after many trade-offs. The ALS program needs a multi-parameter metric including both the ESM and a System Value Metric (SVM). The SVM would include safety, maintainability, reliability, performance, use of cross cutting technology, and commercialization potential. Another major factor in system selection is technology readiness level (TRL), a familiar metric in ALS. The overall ALS system metric that is suggested is a benefit/cost ratio, SVM/[ESM + function (TRL)], with appropriate weighting and scaling. The total value is given by SVM. Cost is represented by higher ESM and lower TRL. The paper provides a detailed description and example application of a suggested System Value Metric and an overall ALS system metric.

Expected Characteristics of Global Wind Profile Measurements with a Scanning, Hybrid, Doppler Lidar System

NASA Technical Reports Server (NTRS)

Kavaya, Michael J.

2008-01-01

Over 20 years of investigation by NASA and NOAA scientists and Doppler lidar technologists into a global wind profiling mission from earth orbit have led to the current favored concept of an instrument with both coherent- and direct-detection pulsed Doppler lidars (i.e., a hybrid Doppler lidar) and a stepstare beam scanning approach covering several azimuth angles with a fixed nadir angle. The nominal lidar wavelengths are 2 microns for coherent detection, and 0.355 microns for direct detection. The two agencies have also generated two sets of sophisticated wind measurement requirements for a space mission: science demonstration requirements and operational requirements. The requirements contain the necessary details to permit mission design and optimization by lidar technologists. Simulations have been developed that connect the science requirements to the wind measurement requirements, and that connect the wind measurement requirements to the Doppler lidar parameters. The simulations also permit trade studies within the multi-parameter space. These tools, combined with knowledge of the state of the Doppler lidar technology, have been used to conduct space instrument and mission design activities to validate the feasibility of the chosen mission and lidar parameters. Recently, the NRC Earth Science Decadal Survey recommended the wind mission to NASA as one of 15 recommended missions. A full description of the wind measurement product from these notional missions and the possible trades available are presented in this paper.

Improved Shaping Approach to the Preliminary Design of Low-Thrust Trajectories

NASA Astrophysics Data System (ADS)

Novak, D. M.; Vasile, M.

2011-01-01

This paper presents a general framework for the development of shape-based approaches to low-thrust trajectory design. A novel shaping method, based on a three-dimensional description of the trajectory in spherical coordinates, is developed within this general framework. Both the exponential sinusoid and the inverse polynomial shaping are demonstrated to be particular two-dimensional cases of the spherical one. The pseudoequinoctial shaping is revisited within the new framework, and the nonosculating nature of the pseudoequinoctial elements is analyzed. A two-step approach is introduced to solve the time of flight constraint, related to the design of low-thrust arcs with boundary constraints for both spherical and pseudoequinoctial shaping. The solution derived from the shaping approach is improved with a feedback linear-quadratic controller and compared against a direct collocation method based on finite elements in time. The new shaping approach and the combination of shaping and linear-quadratic controller are tested on three case studies: a mission to Mars, a mission to asteroid 1989ML, a mission to comet Tempel-1, and a mission to Neptune.

Development and evaluation of statistical shape modeling for principal inner organs on torso CT images.

PubMed

Zhou, Xiangrong; Xu, Rui; Hara, Takeshi; Hirano, Yasushi; Yokoyama, Ryujiro; Kanematsu, Masayuki; Hoshi, Hiroaki; Kido, Shoji; Fujita, Hiroshi

2014-07-01

The shapes of the inner organs are important information for medical image analysis. Statistical shape modeling provides a way of quantifying and measuring shape variations of the inner organs in different patients. In this study, we developed a universal scheme that can be used for building the statistical shape models for different inner organs efficiently. This scheme combines the traditional point distribution modeling with a group-wise optimization method based on a measure called minimum description length to provide a practical means for 3D organ shape modeling. In experiments, the proposed scheme was applied to the building of five statistical shape models for hearts, livers, spleens, and right and left kidneys by use of 50 cases of 3D torso CT images. The performance of these models was evaluated by three measures: model compactness, model generalization, and model specificity. The experimental results showed that the constructed shape models have good "compactness" and satisfied the "generalization" performance for different organ shape representations; however, the "specificity" of these models should be improved in the future.

Teaching Writing on the Shoulders of Giants.

ERIC Educational Resources Information Center

Jensen, Julie M.

2002-01-01

Presents descriptions of influential individuals who have shaped language arts education as it is know today. Elaborates on contributions of: Sylvia Ashton-Warner; Natalie Robinson Cole; Julia Weber Gordon; and Alvina Treut Burrows. (SG)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Houdayer, Jérôme; Poitevin, Frédéric

This paper shows how small-angle scattering (SAS) curves can be decomposed in a simple sum using a set of invariant parameters calledK nwhich are related to the shape of the object of study. TheseK n, together with a radiusR, give a complete theoretical description of the SAS curve. Adding an overall constant, these parameters are easily fitted against experimental data giving a concise comprehensive description of the data. The pair distance distribution function is also entirely described by this invariant set and theD maxparameter can be measured. In addition to the understanding they bring, these invariants can be used tomore » reliably estimate structural moments beyond the radius of gyration, thereby rigorously expanding the actual set of model-free quantities one can extract from experimental SAS data, and possibly paving the way to designing new shape reconstruction strategies.« less

Morphological decomposition of 2-D binary shapes into convex polygons: a heuristic algorithm.

PubMed

Xu, J

2001-01-01

In many morphological shape decomposition algorithms, either a shape can only be decomposed into shape components of extremely simple forms or a time consuming search process is employed to determine a decomposition. In this paper, we present a morphological shape decomposition algorithm that decomposes a two-dimensional (2-D) binary shape into a collection of convex polygonal components. A single convex polygonal approximation for a given image is first identified. This first component is determined incrementally by selecting a sequence of basic shape primitives. These shape primitives are chosen based on shape information extracted from the given shape at different scale levels. Additional shape components are identified recursively from the difference image between the given image and the first component. Simple operations are used to repair certain concavities caused by the set difference operation. The resulting hierarchical structure provides descriptions for the given shape at different detail levels. The experiments show that the decomposition results produced by the algorithm seem to be in good agreement with the natural structures of the given shapes. The computational cost of the algorithm is significantly lower than that of an earlier search-based convex decomposition algorithm. Compared to nonconvex decomposition algorithms, our algorithm allows accurate approximations for the given shapes at low coding costs.

Characterization of Breast Implant Surfaces, Shapes, and Biomechanics: A Comparison of High Cohesive Anatomically Shaped Textured Silicone, Breast Implants from Three Different Manufacturers.

PubMed

Atlan, Michael; Bigerelle, Maxence; Larreta-garde, Véronique; Hindié, Mathilde; Hedén, Per

2016-02-01

Several companies offer anatomically shaped breast implants but differences among manufacturers are often misunderstood. The shell texture is a crucial parameter for anatomically shaped implants to prevent rotation and to decrease the risk of capsular contracture, even though concerns have recently been raised concerning the complications associated with textured breast implants. The aim of this study was to characterize differences in terms of texture, cell adhesion, shape, and stiffness between some commonly used anatomically shaped implants from three different manufacturers. Five commercially available anatomically shaped breast implants from 3 different manufacturers (Allergan, Mentor, and Sebbin) were used. Scanning electron microscopy, X-ray microtomography, and scanning mechanical microscopy were used to characterize the shell texture. Human fibroblast adhesion onto the shells was evaluated. 3D models of the implants were obtained using CT-scan acquisitions to analyze their shape. Implant stiffness was evaluated using a tractiometer. Major differences were observed in the topography of the textures of the shells, but this was not conveyed by a statistically significant fibroblast adhesion difference. However, fibroblasts adhered better on anatomically shaped textured implants than on smooth implants (p < 0.01). Our work pointed out differences in the Biocell® texture in comparison with older studies. The 3D analysis showed significant shape differences between the anatomically shaped implants of the 3 companies, despite similar dimensions. Implant stiffness was comparable among the 3 brands. Each texture had its specific topography, and this work is the first description of Sebbin anatomic breast implant texturation. Moreover, major discrepancies were found in the analysis of the Biocell® texture when comparing our results with previous reports. These differences may have clinical implications and are discussed. This study also highlighted major shape differences among breast implants from different manufacturers, which is quite counterintuitive. The clinical impact of these differences however needs further investigation. This journal requires that authors assign a level of evidence to each submission to which Evidence-Based Medicine rankings are applicable. This excludes Review Articles, Book Reviews, and manuscripts that concern Basic Science, Animal Studies, Cadaver Studies, and Experimental Studies. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

Pulsational mode fluctuations and their basic conservation laws

NASA Astrophysics Data System (ADS)

Borah, B.; Karmakar, P. K.

2015-01-01

We propose a theoretical hydrodynamic model for investigating the basic features of nonlinear pulsational mode stability in a partially charged dust molecular cloud within the framework of the Jeans homogenization assumption. The inhomogeneous cloud is modeled as a quasi-neutral multifluid consisting of the warm electrons, warm ions, and identical inertial cold dust grains with partial ionization in a neutral gaseous background. The grain-charge is assumed not to vary in the fluctuation evolution time scale. The active inertial roles of the thermal species are included. We apply a standard multiple scaling technique centered on the gravito-electrostatic equilibrium to understand the fluctuations on the astrophysical scales of space and time. This is found that electrostatic and self-gravitational eigenmodes co-exist as diverse solitary spectral patterns governed by a pair of Korteweg-de Vries (KdV) equations. In addition, all the relevant classical conserved quantities associated with the KdV system under translational invariance are methodologically derived and numerically analyzed. A full numerical shape-analysis of the fluctuations, scale lengths and perturbed densities with multi-parameter variation of judicious plasma conditions is carried out. A correlation of the perturbed densities and gravito-electrostatic spectral patterns is also graphically indicated. It is demonstrated that the solitary mass, momentum and energy densities also evolve like solitary spectral patterns which remain conserved throughout the spatiotemporal scales of the fluctuation dynamics. Astrophysical and space environments significant to our results are briefly highlighted.

Dissecting pigment architecture of individual photosynthetic antenna complexes in solution

DOE PAGES

Wang, Quan; Moerner, W. E.

2015-10-05

Oligomerization plays a critical role in shaping the light-harvesting properties of many photosynthetic pigment-protein complexes, but a detailed understanding of this process at the level of individual pigments is still lacking. To study the effects of oligomerization, we designed a single-molecule approach to probe the photophysical properties of individual pigment sites as a function of protein assembly state. Our method, based on the principles of anti-Brownian electrokinetic trapping of single fluorescent proteins, step-wise photobleaching, and multiparameter spectroscopy, allows pigment-specific spectroscopic information on single multipigment antennae to be recorded in a nonperturbative aqueous environment with unprecedented detail. We focus on themore » monomer-to-trimer transformation of allophycocyanin (APC), an important antenna protein in cyanobacteria. Here, our data reveal that the two chemically identical pigments in APC have different roles. One (α) is the functional pigment that red-shifts its spectral properties upon trimer formation, whereas the other (β) is a "protective" pigment that persistently quenches the excited state of α in the prefunctional, monomer state of the protein. These results show how subtleties in pigment organization give rise to functionally important aspects of energy transfer and photoprotection in antenna complexes. Finally, the method developed here should find immediate application in understanding the emergent properties of other natural and artificial light-harvesting systems.« less

Multiparameter behavioral profiling reveals distinct thermal response regimes in Caenorhabditis elegans

PubMed Central

2012-01-01

Background Responding to noxious stimuli by invoking an appropriate escape response is critical for survival of an organism. The sensations of small and large changes in temperature in most organisms have been studied separately in the context of thermotaxis and nociception, respectively. Here we use the nematode C. elegans to address the neurogenetic basis of responses to thermal stimuli over a broad range of intensities. Results C. elegans responds to aversive temperature by eliciting a stereotypical behavioral sequence. Upon sensation of the noxious stimulus, it moves backwards, turns and resumes forward movement in a new direction. In order to study the response of C. elegans to a broad range of noxious thermal stimuli, we developed a novel assay that allows simultaneous characterization of multiple aspects of escape behavior elicited by thermal pulses of increasing amplitudes. We exposed the laboratory strain N2, as well as 47 strains with defects in various aspects of nervous system function, to thermal pulses ranging from ΔT = 0.4°C to 9.1°C and recorded the resulting behavioral profiles. Conclusions Through analysis of the multidimensional behavioral profiles, we found that the combinations of molecules shaping avoidance responses to a given thermal pulse are unique. At different intensities of aversive thermal stimuli, these distinct combinations of molecules converge onto qualitatively similar stereotyped behavioral sequences. PMID:23114012

Uncertainty-enabled design of electromagnetic reflectors with integrated shape control

NASA Astrophysics Data System (ADS)

Haque, Samiul; Kindrat, Laszlo P.; Zhang, Li; Mikheev, Vikenty; Kim, Daewa; Liu, Sijing; Chung, Jooyeon; Kuian, Mykhailo; Massad, Jordan E.; Smith, Ralph C.

2018-03-01

We implemented a computationally efficient model for a corner-supported, thin, rectangular, orthotropic polyvinylidene fluoride (PVDF) laminate membrane, actuated by a two-dimensional array of segmented electrodes. The laminate can be used as shape-controlled electromagnetic reflector and the model estimates the reflector's shape given an array of control voltages. In this paper, we describe a model to determine the shape of the laminate for a given distribution of control voltages. Then, we investigate the surface shape error and its sensitivity to the model parameters. Subsequently, we analyze the simulated deflection of the actuated bimorph using a Zernike polynomial decomposition. Finally, we provide a probabilistic description of reflector performance using statistical methods to quantify uncertainty. We make design recommendations for nominal parameter values and their tolerances based on optimization under uncertainty using multiple methods.

Monotonicity preserving splines using rational cubic Timmer interpolation

NASA Astrophysics Data System (ADS)

Zakaria, Wan Zafira Ezza Wan; Alimin, Nur Safiyah; Ali, Jamaludin Md

2017-08-01

In scientific application and Computer Aided Design (CAD), users usually need to generate a spline passing through a given set of data, which preserves certain shape properties of the data such as positivity, monotonicity or convexity. The required curve has to be a smooth shape-preserving interpolant. In this paper a rational cubic spline in Timmer representation is developed to generate interpolant that preserves monotonicity with visually pleasing curve. To control the shape of the interpolant three parameters are introduced. The shape parameters in the description of the rational cubic interpolant are subjected to monotonicity constrained. The necessary and sufficient conditions of the rational cubic interpolant are derived and visually the proposed rational cubic Timmer interpolant gives very pleasing results.

An application of interactive graphics to neutron spectrometry

NASA Technical Reports Server (NTRS)

Binney, S. E.

1972-01-01

The use of interactive graphics is presented as an attractive method for performing multi-parameter data analysis of proton recoil distributions to determine neutron spectra. Interactive graphics allows the user to view results on-line as the program is running and to maintain maximum control over the path along which the calculation will proceed. Other advantages include less time to obtain results and freedom from handling paper tapes and IBM cards.

Battery model for electrical power system energy balance

NASA Technical Reports Server (NTRS)

Hafen, D. P.

1983-01-01

A model to simulate nickel-cadmium battery performance and response in a spacecraft electrical power system energy balance calculation was developed. The voltage of the battery is given as a function of temperature, operating depth-of-charge (DOD), and battery state-of-charge. Also accounted for is charge inefficiency. A battery is modeled by analysis of the results of a multiparameter battery cycling test at various temperatures and DOD's.

Computer program to minimize prediction error in models from experiments with 16 hypercube points and 0 to 6 center points

NASA Technical Reports Server (NTRS)

Holms, A. G.

1982-01-01

A previous report described a backward deletion procedure of model selection that was optimized for minimum prediction error and which used a multiparameter combination of the F - distribution and an order statistics distribution of Cochran's. A computer program is described that applies the previously optimized procedure to real data. The use of the program is illustrated by examples.

[Cluster analysis in biomedical researches].

PubMed

Akopov, A S; Moskovtsev, A A; Dolenko, S A; Savina, G D

2013-01-01

Cluster analysis is one of the most popular methods for the analysis of multi-parameter data. The cluster analysis reveals the internal structure of the data, group the separate observations on the degree of their similarity. The review provides a definition of the basic concepts of cluster analysis, and discusses the most popular clustering algorithms: k-means, hierarchical algorithms, Kohonen networks algorithms. Examples are the use of these algorithms in biomedical research.

Cosmic ray experimental observations

NASA Technical Reports Server (NTRS)

Balasubrahmanyan, V. K.; Mcdonald, F. B.

1974-01-01

The current experimental situation in cosmic ray studies is discussed, with special emphasis on the development of new detector systems. Topics covered are the techniques for particle identification, energy measurements, gas Cerenkov counters, magnet spectrometers, ionization spectrometers, track detectors, nuclear emulsions, multiparameter analysis using arrays of detectors, the Goddard ionization spectrometer, charge spectra, relative abundances, isotope composition, antinuclei in cosmic rays, electrons, the measurement of cosmic ray arrival directions, and the prehistory of cosmic rays.

Simulating Scenario Floods for Hazard Assessment on the Lower Bicol Floodplain, the Philippines

NASA Astrophysics Data System (ADS)

Usamah, Muhibuddin Bin; Alkema, Dinand

This paper describes the first results from a study to the behavior of floods in the lower Bicol area, the Philippines. A 1D2D dynamic hydraulic model was applied to simulate a set of scenario floods through the complex topography of the city Naga and surrounding area. The simulation results are integrated into a multi-parameter hazard zonation for the five scenario floods.

Multiparameter immune profiling of operational tolerance in liver transplantation.

PubMed

Martínez-Llordella, M; Puig-Pey, I; Orlando, G; Ramoni, M; Tisone, G; Rimola, A; Lerut, J; Latinne, D; Margarit, C; Bilbao, I; Brouard, S; Hernández-Fuentes, M; Soulillou, J-P; Sánchez-Fueyo, A

2007-02-01

Immunosuppressive drugs can be completely withdrawn in up to 20% of liver transplant recipients, commonly referred to as 'operationally' tolerant. Immune characterization of these patients, however, has not been performed in detail, and we lack tests capable of identifying tolerant patients among recipients receiving maintenance immunosuppression. In the current study we have analyzed a variety of biological traits in peripheral blood of operationally tolerant liver recipients in an attempt to define a multiparameter 'fingerprint' of tolerance. Thus, we have performed peripheral blood gene expression profiling and extensive blood cell immunophenotyping on 16 operationally tolerant liver recipients, 16 recipients requiring on-going immunosuppressive therapy, and 10 healthy individuals. Microarray profiling identified a gene expression signature that could discriminate tolerant recipients from immunosuppression-dependent patients with high accuracy. This signature included genes encoding for gammadelta T-cell and NK receptors, and for proteins involved in cell proliferation arrest. In addition, tolerant recipients exhibited significantly greater numbers of circulating potentially regulatory T-cell subsets (CD4+ CD25+ T-cells and Vdelta1+ T cells) than either non-tolerant patients or healthy individuals. Our data provide novel mechanistic insight on liver allograft operational tolerance, and constitute a first step in the search for a non-invasive diagnostic signature capable of predicting tolerance before undergoing drug weaning.

Optoelectronic transport properties in amorphous/crystalline silicon solar cell heterojunctions measured by frequency-domain photocarrier radiometry: multi-parameter measurement reliability and precision studies.

PubMed

Zhang, Y; Melnikov, A; Mandelis, A; Halliop, B; Kherani, N P; Zhu, R

2015-03-01

A theoretical one-dimensional two-layer linear photocarrier radiometry (PCR) model including the presence of effective interface carrier traps was used to evaluate the transport parameters of p-type hydrogenated amorphous silicon (a-Si:H) and n-type crystalline silicon (c-Si) passivated by an intrinsic hydrogenated amorphous silicon (i-layer) nanolayer. Several crystalline Si heterojunction structures were examined to investigate the influence of the i-layer thickness and the doping concentration of the a-Si:H layer. The experimental data of a series of heterojunction structures with intrinsic thin layers were fitted to PCR theory to gain insight into the transport properties of these devices. The quantitative multi-parameter results were studied with regard to measurement reliability (uniqueness) and precision using two independent computational best-fit programs. The considerable influence on the transport properties of the entire structure of two key parameters that can limit the performance of amorphous thin film solar cells, namely, the doping concentration of the a-Si:H layer and the i-layer thickness was demonstrated. It was shown that PCR can be applied to the non-destructive characterization of a-Si:H/c-Si heterojunction solar cells yielding reliable measurements of the key parameters.

Optoelectronic transport properties in amorphous/crystalline silicon solar cell heterojunctions measured by frequency-domain photocarrier radiometry: Multi-parameter measurement reliability and precision studies

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Y.; Institute of Electronic Engineering and Optoelectronic Technology, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094; Melnikov, A.

2015-03-15

A theoretical one-dimensional two-layer linear photocarrier radiometry (PCR) model including the presence of effective interface carrier traps was used to evaluate the transport parameters of p-type hydrogenated amorphous silicon (a-Si:H) and n-type crystalline silicon (c-Si) passivated by an intrinsic hydrogenated amorphous silicon (i-layer) nanolayer. Several crystalline Si heterojunction structures were examined to investigate the influence of the i-layer thickness and the doping concentration of the a-Si:H layer. The experimental data of a series of heterojunction structures with intrinsic thin layers were fitted to PCR theory to gain insight into the transport properties of these devices. The quantitative multi-parameter results weremore » studied with regard to measurement reliability (uniqueness) and precision using two independent computational best-fit programs. The considerable influence on the transport properties of the entire structure of two key parameters that can limit the performance of amorphous thin film solar cells, namely, the doping concentration of the a-Si:H layer and the i-layer thickness was demonstrated. It was shown that PCR can be applied to the non-destructive characterization of a-Si:H/c-Si heterojunction solar cells yielding reliable measurements of the key parameters.« less

Applicability and feasibility of systematic review for performing evidence-based risk assessment in food and feed safety.

PubMed

Aiassa, E; Higgins, J P T; Frampton, G K; Greiner, M; Afonso, A; Amzal, B; Deeks, J; Dorne, J-L; Glanville, J; Lövei, G L; Nienstedt, K; O'connor, A M; Pullin, A S; Rajić, A; Verloo, D

2015-01-01

Food and feed safety risk assessment uses multi-parameter models to evaluate the likelihood of adverse events associated with exposure to hazards in human health, plant health, animal health, animal welfare, and the environment. Systematic review and meta-analysis are established methods for answering questions in health care, and can be implemented to minimize biases in food and feed safety risk assessment. However, no methodological frameworks exist for refining risk assessment multi-parameter models into questions suitable for systematic review, and use of meta-analysis to estimate all parameters required by a risk model may not be always feasible. This paper describes novel approaches for determining question suitability and for prioritizing questions for systematic review in this area. Risk assessment questions that aim to estimate a parameter are likely to be suitable for systematic review. Such questions can be structured by their "key elements" [e.g., for intervention questions, the population(s), intervention(s), comparator(s), and outcome(s)]. Prioritization of questions to be addressed by systematic review relies on the likely impact and related uncertainty of individual parameters in the risk model. This approach to planning and prioritizing systematic review seems to have useful implications for producing evidence-based food and feed safety risk assessment.

Power capability evaluation for lithium iron phosphate batteries based on multi-parameter constraints estimation

NASA Astrophysics Data System (ADS)

Wang, Yujie; Pan, Rui; Liu, Chang; Chen, Zonghai; Ling, Qiang

2018-01-01

The battery power capability is intimately correlated with the climbing, braking and accelerating performance of the electric vehicles. Accurate power capability prediction can not only guarantee the safety but also regulate driving behavior and optimize battery energy usage. However, the nonlinearity of the battery model is very complex especially for the lithium iron phosphate batteries. Besides, the hysteresis loop in the open-circuit voltage curve is easy to cause large error in model prediction. In this work, a multi-parameter constraints dynamic estimation method is proposed to predict the battery continuous period power capability. A high-fidelity battery model which considers the battery polarization and hysteresis phenomenon is presented to approximate the high nonlinearity of the lithium iron phosphate battery. Explicit analyses of power capability with multiple constraints are elaborated, specifically the state-of-energy is considered in power capability assessment. Furthermore, to solve the problem of nonlinear system state estimation, and suppress noise interference, the UKF based state observer is employed for power capability prediction. The performance of the proposed methodology is demonstrated by experiments under different dynamic characterization schedules. The charge and discharge power capabilities of the lithium iron phosphate batteries are quantitatively assessed under different time scales and temperatures.

Multiparameter optimization of mammography: an update

NASA Astrophysics Data System (ADS)

Jafroudi, Hamid; Muntz, E. P.; Jennings, Robert J.

1994-05-01

Previously in this forum we have reported the application of multiparameter optimization techniques to the design of a minimum dose mammography system. The approach used a reference system to define the physical imaging performance required and the dose to which the dose for the optimized system should be compared. During the course of implementing the resulting design in hardware suitable for laboratory testing, the state of the art in mammographic imaging changed, so that the original reference system, which did not have a grid, was no longer appropriate. A reference system with a grid was selected in response to this change, and at the same time the optimization procedure was modified, to make it more general and to facilitate study of the optimized design under a variety of conditions. We report the changes in the procedure, and the results obtained using the revised procedure and the up- to-date reference system. Our results, which are supported by laboratory measurements, indicate that the optimized design can image small objects as well as the reference system using only about 30% of the dose required by the reference system. Hardware meeting the specification produced by the optimization procedure and suitable for clinical use is currently under evaluation in the Diagnostic Radiology Department at the Clinical Center, NH.

Continuous neonatal blood gas monitoring using a multiparameter intra-arterial sensor

PubMed Central

Morgan, C; Newell, S; Ducker, D; Hodgkinson, J; White, D; Morley, C; Church, J

1999-01-01

AIMS—To compare arterial blood gas (ABG) readings obtained with a multiparameter intra-arterial sensor with those from an ABG analyser.
METHODS—An MPIAS with the ability to measure continuously pH, PaCO2, and PaO2 was introduced via an umbilical arterial catheter in 27 neonates requiring intensive care. They underwent 3260 hours of MPIAS monitoring, during which 753 ABG readings were performed.
RESULTS—Overall bias (mean difference: MPIAS-ABG) and precision (standard deviation of differences) values were: −0.002 and 0.022,respectively, for pH; +0.26 and 0.52 for PaCO2 (kPa); and −0.19 and 0.99 for PaO2 (kPa). This gave 95% limits of agreement as: −0.047 to +0.042 for pH, −0.76 to +1.28 kPa for PaCO2, and −2.13 to +1.75 kPa for PaO2. For each variable, precision across readings from the same individual was better than overall precision for all data. No complications related to the use of the catheter were observed.
CONCLUSIONS—Continuous MPIAS ABG monitoring is an exciting development, with the potential to reduce blood transfusions and improve ABG homeostasis.

 PMID:10325783

Composite multi-parameter ranking of real and virtual compounds for design of MC4R agonists: renaissance of the Free-Wilson methodology.

PubMed

Nilsson, Ingemar; Polla, Magnus O

2012-10-01

Drug design is a multi-parameter task present in the analysis of experimental data for synthesized compounds and in the prediction of new compounds with desired properties. This article describes the implementation of a binned scoring and composite ranking scheme for 11 experimental parameters that were identified as key drivers in the MC4R project. The composite ranking scheme was implemented in an AstraZeneca tool for analysis of project data, thereby providing an immediate re-ranking as new experimental data was added. The automated ranking also highlighted compounds overlooked by the project team. The successful implementation of a composite ranking on experimental data led to the development of an equivalent virtual score, which was based on Free-Wilson models of the parameters from the experimental ranking. The individual Free-Wilson models showed good to high predictive power with a correlation coefficient between 0.45 and 0.97 based on the external test set. The virtual ranking adds value to the selection of compounds for synthesis but error propagation must be controlled. The experimental ranking approach adds significant value, is parameter independent and can be tuned and applied to any drug discovery project.

Multiparameter flow cytometry reveals myelodysplasia-related aberrant antigen expression in myelodysplastic/myeloproliferative neoplasms.

PubMed

Kern, Wolfgang; Bacher, Ulrike; Schnittger, Susanne; Alpermann, Tamara; Haferlach, Claudia; Haferlach, Torsten

2013-05-01

Within the myelodysplastic/myeloproliferative neoplasm (MDS/MPN) category of the WHO (2008), only chronic myelomonocytic leukemia was so far evaluated by multiparameter flow cytometry (MFC). To investigate the potential of MFC for MDS/MPNs, unclassifiable (MDS/MPNu), and refractory anemia associated with ring sideroblasts and marked thrombocytosis (RARS-T), we studied 91 patients with these entities (60 males/31 females; 35.3-87.4 years) for MDS-related aberrant immunophenotypes (≥ 2 different cell lineages with ≥ 3 aberrantly expressed antigens). Data were correlated with cytomorphology and cytogenetics. MFC identified MDS-related immunophenotypes in 54/91 (59.3%) of patients. Patients with or without MDS-related immunophenotype did not differ significantly by demographic characteristics, blood values, or median overall survival. MDS-related immunophenotype cases showed a higher number of aberrantly expressed antigens (mean ± SD, 4.9 ± 2.4 vs. 2.0 ± 1.4; P < 0.001). Aberrant karyotypes showed a similar frequency in patients with and without MDS-related immunophenotype (11/54; 20.4% vs. 7/37; 18.9%; P = n.s.). MDS-related immunophenotype are present in more than half of patients with MDS/MPNu and RARS-T. MFC therefore may be helpful to separate cases into more "MDS-like" or "MPN-like" subgroups. Copyright © 2012 International Clinical Cytometry Society.

A three-dimensional, compressible, laminar boundary-layer method for general fuselages. Volume 2: User's manual

NASA Technical Reports Server (NTRS)

Wie, Yong-Sun

1990-01-01

This user's manual contains a complete description of the computer programs developed to calculate three-dimensional, compressible, laminar boundary layers for perfect gas flow on general fuselage shapes. These programs include the 3-D boundary layer program (3DBLC), the body-oriented coordinate program (BCC), and the streamline coordinate program (SCC). Subroutine description, input, output and sample case are discussed. The complete FORTRAN listings of the computer programs are given.

Influences shaping nurses' use of distraction for children's procedural pain.

PubMed

Olmstead, Deborah L; Scott, Shannon D; Mayan, Maria; Koop, Priscilla M; Reid, Kathy

2014-04-01

This study explored pediatric nurses' choices to use distraction for managing painful procedures. Using interpretive description approaches, interviews with pediatric nurses provided descriptions of choices to manage procedural pain. Nurses' distress influenced distraction use to mitigate the suffering of children and themselves. Newer nurses described task mastery as influencing distraction choices. Nurses' accounts of performing painful procedures on children mirrored children's descriptions of pain from the literature. Nurses' distress and competency performing painful procedures on children influenced practice. Future qualitative studies could extend understanding of pain management choices by pediatric nurses and the impact on undermanaged pain. © 2014, Wiley Periodicals, Inc.

Shape in Picture: Mathematical Description of Shape in Grey-Level Images

DTIC Science & Technology

1992-09-11

representation is scale-space, derived frrr- the linear isotropic diffusion equation; recently other types of equations have been considered. Multiscale...recognition of dimensions in the general case of an arbitrary denominator is similar to that just explained. 3 Linear Inequalities in the Two-Dimensional...solid region containing all pixels of the space, whose coordinates satisfy a linear inequality. A Um C scspt fr Digital Geometry 41 s a a v--’ -0 7 O

What was your question again? Types of medical studies.

PubMed

Jupiter, Daniel C

2014-01-01

Medical literature comes in all shapes and sizes, from animal studies to prospective clinical trials to retrospective chart reviews. In all of these cases, it is worth asking: What are the intellectual goals of the study: description, hypothesis testing, or hypothesis generating? This differentiation can help shape our view of the success or failure of the scientific effort. Copyright © 2014 American College of Foot and Ankle Surgeons. Published by Elsevier Inc. All rights reserved.

Does shape co-variation between the skull and the mandible have functional consequences? A 3D approach for a 3D problem

PubMed Central

Cornette, Raphaël; Baylac, Michel; Souter, Thibaud; Herrel, Anthony

2013-01-01

Morpho-functional patterns are important drivers of phenotypic diversity given their importance in a fitness-related context. Although modularity of the mandible and skull has been studied extensively in mammals, few studies have explored shape co-variation between these two structures. Despite being developmentally independent, the skull and mandible form a functionally integrated unit. In the present paper we use 3D surface geometric morphometric methods allowing us to explore the form of both skull and mandible in its 3D complexity using the greater white-toothed shrew as a model. This approach allows an accurate 3D description of zones devoid of anatomical landmarks that are functionally important. Two-block partial least-squares approaches were used to describe the co-variation of form between skull and mandible. Moreover, a 3D biomechanical model was used to explore the functional consequences of the observed patterns of co-variation. Our results show the efficiency of the method in investigations of complex morpho-functional patterns. Indeed, the description of shape co-variation between the skull and the mandible highlighted the location and the intensity of their functional relationships through the jaw adductor muscles linking these two structures. Our results also demonstrated that shape co-variation in form between the skull and mandible has direct functional consequences on the recruitment of muscles during biting. PMID:23964811

Simulation loop between cad systems, GEANT-4 and GeoModel: Implementation and results

NASA Astrophysics Data System (ADS)

Sharmazanashvili, A.; Tsutskiridze, Niko

2016-09-01

Compare analysis of simulation and as-built geometry descriptions of detector is important field of study for data_vs_Monte-Carlo discrepancies. Shapes consistency and detalization is not important while adequateness of volumes and weights of detector components are essential for tracking. There are 2 main reasons of faults of geometry descriptions in simulation: (1) Difference between simulated and as-built geometry descriptions; (2) Internal inaccuracies of geometry transformations added by simulation software infrastructure itself. Georgian Engineering team developed hub on the base of CATIA platform and several tools enabling to read in CATIA different descriptions used by simulation packages, like XML->CATIA; VP1->CATIA; Geo-Model->CATIA; Geant4->CATIA. As a result it becomes possible to compare different descriptions with each other using the full power of CATIA and investigate both classes of reasons of faults of geometry descriptions. Paper represents results of case studies of ATLAS Coils and End-Cap toroid structures.

40 CFR 463.20 - Applicability; description of the cleaning water subcategory.

Code of Federal Regulations, 2011 CFR

2011-07-01

... the cleaning water subcategory are processes where water comes in contact with the plastic product for the purpose of cleaning the surface of the product and where water comes in contact with shaping...

Anatomical medial surfaces with efficient resolution of branches singularities.

PubMed

Gil, Debora; Vera, Sergio; Borràs, Agnés; Andaluz, Albert; González Ballester, Miguel A

2017-01-01

Medial surfaces are powerful tools for shape description, but their use has been limited due to the sensibility of existing methods to branching artifacts. Medial branching artifacts are associated to perturbations of the object boundary rather than to geometric features. Such instability is a main obstacle for a confident application in shape recognition and description. Medial branches correspond to singularities of the medial surface and, thus, they are problematic for existing morphological and energy-based algorithms. In this paper, we use algebraic geometry concepts in an energy-based approach to compute a medial surface presenting a stable branching topology. We also present an efficient GPU-CPU implementation using standard image processing tools. We show the method computational efficiency and quality on a custom made synthetic database. Finally, we present some results on a medical imaging application for localization of abdominal pathologies. Copyright © 2016 Elsevier B.V. All rights reserved.

A 3D model for rubber tyres contact, based on Kalker's methods through the STRIPES model

NASA Astrophysics Data System (ADS)

Chollet, Hugues

2012-01-01

A project on the pavement-rutting evolution under the effect of a tram on tyre, led the author to make a link between road and railway approaches to the problem of rolling contact. A simplified model is proposed with a fine description of the contact patch between a tyre and the road, and a more realistic pressure and shear stresses distribution than that available from basic models previously available. Experimental measurements are used to identify some characteristics of the force description, while the geometric shape of the tyre-road section are used, like in the traditional rail-wheel contact models, to build the 3D model. The last part validates a plausible contact pressure shape from self-aligning torque measurements and from Kalker's contact stresses gradient applied to the real tyre used in the project. The final result is a brush model extended from the wheel-rail STRIPES one, applicable to dynamics or contact studies of real tyres, with a physical coupling between longitudinal, lateral and spin effects, and a relatively fine description of the contact stresses along each strip of each tyre of the vehicle on an uneven road.

An experimental study of mushroom shaped stall cells. [on finite wings with separated flow

NASA Technical Reports Server (NTRS)

Winkelmann, A. E.

1982-01-01

Surface patterns characterized by a pair of counter-rotating swirls have been observed in connection with the conduction of surface flow visualization experiments involving test geometries with separated flows. An example of this phenomenon occurring on a finite wing with trailing edge stall has been referred to by Winkelmann and Barlow (1980) as 'mushroom shaped'. A description is presented of a collection of experimental results which show or suggest the occurrence of mushroom shaped stall cells on a variety of test geometries. Investigations conducted with finite wings, airfoil models, and flat plates are considered, and attention is given to studies involving the use of bluff models, investigations of shock induced boundary layer separation, and mushroom shaped patterns observed in a number of miscellaneous cases. It is concluded that the mushroom shaped stall cell appears commonly in separated flow regions.

CORRIGENDUM: A new algorithm for the shape reconstruction of perfectly conducting objects A new algorithm for the shape reconstruction of perfectly conducting objects

NASA Astrophysics Data System (ADS)

Çayören, M.; Akduman, I.; Yapar, A.; Crocco, L.

2010-03-01

The reference list should have included the conference communications [1] and [2], wherein we introduced the algorithm described in this paper. Note that a less complete description of the algorithm was given in [1]. However, the example considering a bean-shaped target is the same in the two papers and it is reused in this paper by kind permission of the Applied Computational Electromagnetics Society. References [1] Crocco L, Akduman I, Çayören M and Yapar A 2007 A new method for shape reconstruction of perfectly conducting targets The 23rd Annual Review of Progress in Applied Computational Electromagnetics (Verona, Italy) [2] Çayören M, Akduman I, Yapar A and Crocco L 2007 A new algorithm for the shape reconstruction of perfectly conducting objects Progress in Electromagnetics Research Symposium (PIERS) (Beijing, PRC)

Fast surface-based travel depth estimation algorithm for macromolecule surface shape description.

PubMed

Giard, Joachim; Alface, Patrice Rondao; Gala, Jean-Luc; Macq, Benoît

2011-01-01

Travel Depth, introduced by Coleman and Sharp in 2006, is a physical interpretation of molecular depth, a term frequently used to describe the shape of a molecular active site or binding site. Travel Depth can be seen as the physical distance a solvent molecule would have to travel from a point of the surface, i.e., the Solvent-Excluded Surface (SES), to its convex hull. Existing algorithms providing an estimation of the Travel Depth are based on a regular sampling of the molecule volume and the use of the Dijkstra's shortest path algorithm. Since Travel Depth is only defined on the molecular surface, this volume-based approach is characterized by a large computational complexity due to the processing of unnecessary samples lying inside or outside the molecule. In this paper, we propose a surface-based approach that restricts the processing to data defined on the SES. This algorithm significantly reduces the complexity of Travel Depth estimation and makes possible the analysis of large macromolecule surface shape description with high resolution. Experimental results show that compared to existing methods, the proposed algorithm achieves accurate estimations with considerably reduced processing times.

Syntactic methods of shape feature description and its application in analysis of medical images

NASA Astrophysics Data System (ADS)

Ogiela, Marek R.; Tadeusiewicz, Ryszard

2000-02-01

The paper presents specialist algorithms of morphologic analysis of shapes of selected organs of abdominal cavity proposed in order to diagnose disease symptoms occurring in the main pancreatic ducts and upper segments of ureters. Analysis of the correct morphology of these structures has been conducted with the use of syntactic methods of pattern recognition. Its main objective is computer-aided support to early diagnosis of neoplastic lesions and pancreatitis based on images taken in the course of examination with the endoscopic retrograde cholangiopancreatography (ERCP) method and a diagnosis of morphological lesions in ureter based on kidney radiogram analysis. In the analysis of ERCP images, the main objective is to recognize morphological lesions in pancreas ducts characteristic for carcinoma and chronic pancreatitis. In the case of kidney radiogram analysis the aim is to diagnose local irregularity of ureter lumen. Diagnosing the above mentioned lesion has been conducted with the use of syntactic methods of pattern recognition, in particular the languages of shape features description and context-free attributed grammars. These methods allow to recognize and describe in a very efficient way the aforementioned lesions on images obtained as a result of initial image processing into diagrams of widths of the examined structures.

Shape coexistence from lifetime and branching-ratio measurements in 68,70Ni

DOE PAGES

Crider, B. P.; Prokop, C. J.; Liddick, S. N.; ...

2016-10-15

Shape coexistence near closed-shell nuclei, whereby states associated with deformed shapes appear at relatively low excitation energy alongside spherical ones, is indicative of the rapid change in structure that can occur with the addition or removal of a few protons or neutrons. Near 68Ni (Z=28, N=40), the identification of shape coexistence hinges on hitherto undetermined transition rates to and from low-energy 0 + states. In 68,70Ni, new lifetimes and branching ratios have been measured. These data enable quantitative descriptions of the 0 + states through the deduced transition rates and serve as sensitive probes for characterizing their nuclear wave functions.more » The results are compared to, and consistent with, large-scale shell-model calculations which predict shape coexistence. With the firm identification of this phenomenon near 68Ni, shape coexistence is now observed in all currently accessible regions of the nuclear chart with closed proton shells and mid-shell neutrons.« less

Extensions of different type parameterized inequalities for generalized [Formula: see text]-preinvex mappings via k-fractional integrals.

PubMed

Zhang, Yao; Du, Ting-Song; Wang, Hao; Shen, Yan-Jun; Kashuri, Artion

2018-01-01

The authors discover a general k -fractional integral identity with multi-parameters for twice differentiable functions. By using this integral equation, the authors derive some new bounds on Hermite-Hadamard's and Simpson's inequalities for generalized [Formula: see text]-preinvex functions through k -fractional integrals. By taking the special parameter values for various suitable choices of function h , some interesting results are also obtained.

ACTS propagation experiment discussion: Ka-band propagation measurements using the ACTS propagation terminal and the CSU-CHILL and Space Communications Technology Center Florida propagation program

NASA Technical Reports Server (NTRS)

Bringi, V. N.; Chandrasekar, V.; Mueller, Eugene A.; Turk, Joseph; Beaver, John; Helmken, Henry F.; Henning, Rudy

1993-01-01

Papers on Ka-band propagation measurements using the ACTS propagation terminal and the Colorado State University CHILL multiparameter radar and on Space Communications Technology Center Florida Propagation Program are discussed. Topics covered include: microwave radiative transfer and propagation models; NASA propagation terminal status; ACTS channel characteristics; FAU receive only terminal; FAU terminal status; and propagation testbed.

Netcast™ Shape Casting Technology: A Technological Breakthrough that Enhances the Cost Effectiveness of Aluminum Forgings

NASA Astrophysics Data System (ADS)

Anderson, Mark; Bruski, Richard; Groszkiewicz, Daniel; Wagstaff, Bob

A new Direct Chill (DC) casting process is introduced to semi-continuous casting where near net shaped ingots are solidified. This process is currently being used at Alcan Engineered Cast Products (ECP) facility in Jonquiere, Canada, sectioned, then forged at Alcoa Automotive, Kentucky Casting Center (KCC). Finished forgings are machined and assembled into the Ford D/EW98 platform as suspension components. A brief description of the process and the implications on the forging process are presented.

49 CFR 173.59 - Description of terms for explosives.

Code of Federal Regulations, 2013 CFR

2013-10-01

... MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS SHIPPERS... other material containing only propellant explosive. The term excludes charges, shaped, commercial...-flammable materials, in which only the explosive component is the primer. Cases, combustible, empty, without...

49 CFR 173.59 - Description of terms for explosives.

Code of Federal Regulations, 2014 CFR

2014-10-01

... MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS SHIPPERS... other material containing only propellant explosive. The term excludes charges, shaped, commercial...-flammable materials, in which only the explosive component is the primer. Cases, combustible, empty, without...

Forces and dynamics in epithelial domes of controlled size and shape

NASA Astrophysics Data System (ADS)

Latorre-Ibars, Ernest; Casares, Laura; Gomez-Gonzalez, Manuel; Uroz, Marina; Arroyo, Marino; Trepat, Xavier

Mechanobiology of epithelia plays a central role in morphogenesis, wound healing, and tumor progression. Its current understanding relies on mechanical measurements on flat epithelial layers. However, most epithelia in vivo exhibit a curved 3D shape enclosing a pressurized lumen. Using soft micropatterned substrates we produce massive parallel arrays of epithelial domes with controlled size and basal shape. We measure epithelial traction, tension, and luminal pressure in epithelial domes. The local stress tensor on the freestanding epithelial membrane is then mapped by combining measured luminal pressure and local curvature. We show that tension and cell shape are highly anisotropic and vary along the meridional position of the domes. Finally, we establish constitutive relations between shape, tension, and pressure during perturbations of the contractile machinery, osmotic shocks, and spontaneous fluctuations of dome volume. Our findings contradict a description of the epithelium as a fluid capillary surface. Cells in the dome are unable to relax into a uniform and isotropic tensional state through sub- and supra-cellular rearrangements. Mapping epithelial shape, tension, and pressure will enable quantitative studies of mechanobiology in 3D epithelia of controlled size and shape.

Statistical Analyses of Brain Surfaces Using Gaussian Random Fields on 2-D Manifolds

PubMed Central

Staib, Lawrence H.; Xu, Dongrong; Zhu, Hongtu; Peterson, Bradley S.

2008-01-01

Interest in the morphometric analysis of the brain and its subregions has recently intensified because growth or degeneration of the brain in health or illness affects not only the volume but also the shape of cortical and subcortical brain regions, and new image processing techniques permit detection of small and highly localized perturbations in shape or localized volume, with remarkable precision. An appropriate statistical representation of the shape of a brain region is essential, however, for detecting, localizing, and interpreting variability in its surface contour and for identifying differences in volume of the underlying tissue that produce that variability across individuals and groups of individuals. Our statistical representation of the shape of a brain region is defined by a reference region for that region and by a Gaussian random field (GRF) that is defined across the entire surface of the region. We first select a reference region from a set of segmented brain images of healthy individuals. The GRF is then estimated as the signed Euclidean distances between points on the surface of the reference region and the corresponding points on the corresponding region in images of brains that have been coregistered to the reference. Correspondences between points on these surfaces are defined through deformations of each region of a brain into the coordinate space of the reference region using the principles of fluid dynamics. The warped, coregistered region of each subject is then unwarped into its native space, simultaneously bringing into that space the map of corresponding points that was established when the surfaces of the subject and reference regions were tightly coregistered. The proposed statistical description of the shape of surface contours makes no assumptions, other than smoothness, about the shape of the region or its GRF. The description also allows for the detection and localization of statistically significant differences in the shapes of the surfaces across groups of subjects at both a fine and coarse scale. We demonstrate the effectiveness of these statistical methods by applying them to study differences in shape of the amygdala and hippocampus in a large sample of normal subjects and in subjects with attention deficit/hyperactivity disorder (ADHD). PMID:17243583

Systematic description of the effect of particle shape on the strength properties of granular media

NASA Astrophysics Data System (ADS)

Azéma, Emilien; Estrada, Nicolas; Preechawuttipong, Itthichai; Delenne, Jean-Yves; Radjai, Farhang

2017-06-01

In this paper, we explore numerically the effect of particle shape on the mechanical behavior of sheared granular packings. In the framework of the Contact Dynamic (CD)Method, we model angular shape as irregular polyhedral particles, non-convex shape as regular aggregates of four overlapping spheres, elongated shape as rounded cap rectangles and platy shape as square-plates. Binary granular mixture consisting of disks and elongated particles are also considered. For each above situations, the number of face of polyhedral particles, the overlap of spheres, the aspect ratio of elongated and platy particles, are systematically varied from spheres to very angular, non-convex, elongated and platy shapes. The level of homogeneity of binary mixture varies from homogenous packing to fully segregated packings. Our numerical results suggest that the effects of shape parameters are nonlinear and counterintuitive. We show that the shear strength increases as shape deviate from spherical shape. But, for angular shapes it first increases up to a maximum value and then saturates to a constant value as the particles become more angular. For mixture of two shapes, the strength increases with respect of the increase of the proportion of elongated particles, but surprisingly it is independent with the level of homogeneity of the mixture. A detailed analysis of the contact network topology, evidence that various contact types contribute differently to stress transmission at the micro-scale.

Variational and WKB Descriptions of Laterally Localized Eigenmodes in Non-Collinear Optical Parametric Amplifiers

DOE Office of Scientific and Technical Information (OSTI.GOV)

Afeyan, Bedros; Charbonneau-Lefort, Mathieu; Fejer, Martin

With a finite lateral width pump, non-collinear interactions result in metastable or stable laterally localized bound states. The physical processes involved are group velocity walk-off, diffraction, chirped QPM gratings and different pump shapes.

49 CFR 173.59 - Description of terms for explosives.

Code of Federal Regulations, 2012 CFR

2012-10-01

... perforating guns, charged, oil well, without detonator. Articles consisting of a steel tube or metallic strip... MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION HAZARDOUS MATERIALS REGULATIONS SHIPPERS... fiber, metal or other material containing only propellant explosive. The term excludes charges, shaped...

When are circular lesions square? A national clinical education skin lesion audit and study.

PubMed

Miranda, Benjamin H; Herman, Katie A; Malahias, Marco; Juma, Ali

2014-09-01

Skin cancer is the most prevalent cancer by organ type and referral accuracy is vital for diagnosis and management. The British Association of Dermatologists (BAD) and literature highlight the importance of accurate skin lesion examination, diagnosis and educationally-relevant studies. We undertook a review of the relevant literature, a national audit of skin lesion description standards and a study of speciality training influences on these descriptions. Questionnaires (n=200), with pictures of a circular and an oval lesion, were distributed to UK dermatology/plastic surgery consultants and speciality trainees (ST), general practitioners (GP), and medical students (MS). The following variables were analysed against a pre-defined 95% inclusion accuracy standard: site, shape, size, skin/colour, and presence of associated scars. There were 250 lesion descriptions provided by 125 consultants, STs, GPs, and MSs. Inclusion accuracy was greatest for consultants over STs (80% vs. 68%; P<0.001), GPs (57%) and MSs (46%) (P<0.0001), for STs over GPs (P<0.010) and MSs (P<0.0001) and for GPs over MSs (P<0.010), all falling below audit standard. Size description accuracy sub-analysis according to circular/oval dimensions was as follows: consultants (94%), GPs (80%), STs (73%), MSs (37%), with the most common error implying a quadrilateral shape (66%). Addressing BAD guidelines and published requirements for more empirical performance data to improve teaching methods, we performed a national audit and studied skin lesion descriptions. To improve diagnostic and referral accuracy for patients, healthcare professionals must strive towards accuracy (a circle is not a square). We provide supportive evidence that increased speciality training improves this process and propose that greater focus is placed on such training early on during medical training, and maintained throughout clinical practice.

Intra- and inter-observer agreement when using a descriptive classification scale for clinical assessment of faecal consistency in growing pigs.

PubMed

Pedersen, Ken Steen; Toft, Nils

2011-03-01

The objective of the current study was to evaluate intra- and inter-observer agreement using a descriptive classification scale with four categories, descriptive text and pictures for assessment of consistency in faecal samples from pigs post weaning. The four consistency categories were score one=firm and shaped, score two=soft and shaped, score three=loose and score four=watery. Five observers from the same veterinary practice examined 100 faecal samples using the scale with four categories. Four of the observers examined the 100 faecal samples twice within the same day. Within observers the difference in proportions for the individual consistency categories between two examinations was on average 0.04 (range: 0-0.10). The mean intra-observer agreement was 0.82 (range: 0.72-0.91) with a mean kappa value of 0.76 (range: 0.61-0.88). For inter-observer agreement overall kappa was 0.64. For the 10 pair-wise comparisons the mean inter-observer agreement was 0.73 (range: 0.61-0.90) with a mean kappa value of 0.64 (range: 0.48-0.87). The difference in proportions for the individual consistency categories was on average 0.08 (range: 0-0.17). In conclusion, the agreement observed for the descriptive classification scale with four categories, descriptive text and pictures may be categorized as a substantial to almost perfect intra-observer agreement and a moderate to almost perfect inter-observer agreement. However, more objective measures than clinical scales may still be needed to improve intra- and inter-observer agreement in research studies. Copyright © 2010 Elsevier B.V. All rights reserved.

Real-Time Description of the Electronic Dynamics for a Molecule Close to a Plasmonic Nanoparticle

PubMed Central

2016-01-01

The optical properties of molecules close to plasmonic nanostructures greatly differ from their isolated molecule counterparts. To theoretically investigate such systems from a quantum-chemistry perspective, one has to take into account that the plasmonic nanostructure (e.g., a metal nanoparticle–NP) is often too large to be treated atomistically. Therefore, a multiscale description, where the molecule is treated by an ab initio approach and the metal NP by a lower level description, is needed. Here we present an extension of one such multiscale model [Corni, S.; Tomasi, J. J. Chem. Phys.2001, 114, 3739], originally inspired by the polarizable continuum model, to a real-time description of the electronic dynamics of the molecule and of the NP. In particular, we adopt a time-dependent configuration interaction (TD CI) approach for the molecule, the metal NP is described as a continuous dielectric of complex shape characterized by a Drude–Lorentz dielectric function, and the molecule–NP electromagnetic coupling is treated by an equation-of-motion (EOM) extension of the quasi-static boundary element method (BEM). The model includes the effects of both the mutual molecule–NP time-dependent polarization and the modification of the probing electromagnetic field due to the plasmonic resonances of the NP. Finally, such an approach is applied to the investigation of the light absorption of a model chromophore, LiCN, in the presence of a metal–NP of complex shape. PMID:28035246

The role of shape complexity in the detection of closed contours.

PubMed

Wilder, John; Feldman, Jacob; Singh, Manish

2016-09-01

The detection of contours in noise has been extensively studied, but the detection of closed contours, such as the boundaries of whole objects, has received relatively little attention. Closed contours pose substantial challenges not present in the simple (open) case, because they form the outlines of whole shapes and thus take on a range of potentially important configural properties. In this paper we consider the detection of closed contours in noise as a probabilistic decision problem. Previous work on open contours suggests that contour complexity, quantified as the negative log probability (Description Length, DL) of the contour under a suitably chosen statistical model, impairs contour detectability; more complex (statistically surprising) contours are harder to detect. In this study we extended this result to closed contours, developing a suitable probabilistic model of whole shapes that gives rise to several distinct though interrelated measures of shape complexity. We asked subjects to detect either natural shapes (Exp. 1) or experimentally manipulated shapes (Exp. 2) embedded in noise fields. We found systematic effects of global shape complexity on detection performance, demonstrating how aspects of global shape and form influence the basic process of object detection. Copyright © 2015 Elsevier Ltd. All rights reserved.

Theoretical study of triaxial shapes of neutron-rich Mo and Ru nuclei

DOE PAGES

Zhang, C. L.; Bhat, G. H.; Nazarewicz, W.; ...

2015-09-10

Here, whether atomic nuclei can possess triaxial shapes at their ground states is still a subject of ongoing debate. According to theory, good prospects for low-spin triaxiality are in the neutron-rich Mo-Ru region. Recently, transition quadrupole moments in rotational bands of even-mass neutron-rich isotopes of molybdenum and ruthenium nuclei have been measured. The new data have provided a challenge for theoretical descriptions invoking stable triaxial deformations. The purpose of this study is to understand experimental data on rotational bands in the neutron-rich Mo-Ru region, we carried out theoretical analysis of moments of inertia, shapes, and transition quadrupole moments of neutron-richmore » even-even nuclei around 110Ru using self-consistent mean-field and shell model techniques. Methods: To describe yrast structures in Mo and Ru isotopes, we use nuclear density functional theory (DFT) with the optimized energy density functional UNEDF0. We also apply triaxial projected shell model (TPSM) to describe yrast and positive-parity, near-yrast band structures. As a result, our self-consistent DFT calculations predict triaxial ground-state deformations in 106,108Mo and 108,110,112Ru and reproduce the observed low-frequency behavior of moments of inertia. As the rotational frequency increases, a negative-gamma structure, associated with the aligned ν(h 11/2) 2 pair, becomes energetically favored. The computed transition quadrupole moments vary with angular momentum, which reflects deformation changes with rotation; those variations are consistent with experiment. The TPSM calculations explain the observed band structures assuming stable triaxial shapes. Lastly, the structure of neutron-rich even-even nuclei around Ru-110 is consistent with triaxial shape deformations. Our DFT and TPSM frameworks provide a consistent and complementary description of experimental data.« less

Pre-equilibrium dynamics and heavy-ion observables

NASA Astrophysics Data System (ADS)

Heinz, Ulrich; Liu, Jia

2016-12-01

To bracket the importance of the pre-equilibrium stage on relativistic heavy-ion collision observables, we compare simulations where it is modeled by either free-streaming partons or fluid dynamics. These cases implement the assumptions of extremely weak vs. extremely strong coupling in the initial collision stage. Accounting for flow generated in the pre-equilibrium stage, we study the sensitivity of radial, elliptic and triangular flow on the switching time when the hydrodynamic description becomes valid. Using the hybrid code iEBE-VISHNU [C. Shen, Z. Qiu, H. Song, J. Bernhard, S. Bass and U. Heinz, Comput. Phys. Commun. 199 (2016) 61] we perform a multi-parameter search, constrained by particle ratios, integrated elliptic and triangular charged hadron flow, the mean transverse momenta of pions, kaons and protons, and the second moment < pT2 > of the proton transverse momentum spectrum, to identify optimized values for the switching time τs from pre-equilibrium to hydrodynamics, the specific shear viscosity η / s, the normalization factor of the temperature-dependent specific bulk viscosity (ζ / s) (T), and the switching temperature Tsw from viscous hydrodynamics to the hadron cascade UrQMD. With the optimized parameters, we predict and compare with experiment the pT-distributions of π, K, p, Λ, Ξ and Ω yields and their elliptic flow coefficients, focusing specifically on the mass-ordering of the elliptic flow for protons and Lambda hyperons which is incorrectly described by VISHNU without pre-equilibrium flow.

Flow Cytometric Analysis of Mononuclear Phagocytes in Nondiseased Human Lung and Lung-Draining Lymph Nodes.

PubMed

Desch, A Nicole; Gibbings, Sophie L; Goyal, Rajni; Kolde, Raivo; Bednarek, Joe; Bruno, Tullia; Slansky, Jill E; Jacobelli, Jordan; Mason, Robert; Ito, Yoko; Messier, Elise; Randolph, Gwendalyn J; Prabagar, Miglena; Atif, Shaikh M; Segura, Elodie; Xavier, Ramnik J; Bratton, Donna L; Janssen, William J; Henson, Peter M; Jakubzick, Claudia V

2016-03-15

The pulmonary mononuclear phagocyte system is a critical host defense mechanism composed of macrophages, monocytes, monocyte-derived cells, and dendritic cells. However, our current characterization of these cells is limited because it is derived largely from animal studies and analysis of human mononuclear phagocytes from blood and small tissue resections around tumors. Phenotypic and morphologic characterization of mononuclear phagocytes that potentially access inhaled antigens in human lungs. We acquired and analyzed pulmonary mononuclear phagocytes from fully intact nondiseased human lungs (including the major blood vessels and draining lymph nodes) obtained en bloc from 72 individual donors. Differential labeling of hematopoietic cells via intrabronchial and intravenous administration of antibodies within the same lobe was used to identify extravascular tissue-resident mononuclear phagocytes and exclude cells within the vascular lumen. Multiparameter flow cytometry was used to identify mononuclear phagocyte populations among cells labeled by each route of antibody delivery. We performed a phenotypic analysis of pulmonary mononuclear phagocytes isolated from whole nondiseased human lungs and lung-draining lymph nodes. Five pulmonary mononuclear phagocytes were observed, including macrophages, monocyte-derived cells, and dendritic cells that were phenotypically distinct from cell populations found in blood. Different mononuclear phagocytes, particularly dendritic cells, were labeled by intravascular and intrabronchial antibody delivery, countering the notion that tissue and blood mononuclear phagocytes are equivalent systems. Phenotypic descriptions of the mononuclear phagocytes in nondiseased lungs provide a precedent for comparative studies in diseased lungs and potential targets for therapeutics.

Ka-Band Propagation Studies using the ACTS Propagation Terminal and the CSU-CHILL Multiparameter Radar

NASA Technical Reports Server (NTRS)

Bringi, V. N.; Beaver, John

1996-01-01

One of the first experimental communications satellites using Ka-band technology is the NASA Advanced Communications Technology Satellite (ACTS). In September 1993, ACTS was deployed into a geostationary orbit near 100 degrees W longitude by the space shuttle Discovery. The ACTS system supports both communication and propagation experiments at the 20/30 GHz frequency bands. The propagation experiment involves multi-year attenuation measurements along the satellite-Earth slant path.

Multi-parameter MRI in the 6-OPRI variant of inherited prion disease

PubMed Central

De Vita, Enrico; Ridgway, Gerard R.; Scahill, Rachael I; Caine, Diana; Rudge, Peter; Yousry, Tarek A; Mead, Simon; Collinge, John; Jäger, H R; Thornton, John S; Hyare, Harpreet

2013-01-01

Background and Purpose To define the distribution of cerebral volumetric and microstructural parenchymal tissue changes in a specific mutation within inherited human prion diseases (IPD) combining voxel-based morphometry (VBM) with voxel-based analysis (VBA) of cerebral magnetization transfer ratio (MTR) and mean diffusivity (MD). Materials and Methods VBM and VBA of cerebral MTR and MD were performed in 16 healthy controls and 9 patients with the 6-octapeptide repeat insertion (6-OPRI) mutation. An ANCOVA consisting of diagnostic grouping with age and total intracranial volume as covariates was performed. Results On VBM there was significant grey matter (GM) volume reduction in patients compared with controls in the basal ganglia, perisylvian cortex, lingual gyrus and precuneus. Significant MTR reduction and MD increases were more anatomically extensive than volume differences on VBM in the same cortical areas, but MTR and MD changes were not seen in the basal ganglia. Conclusions GM and WM changes were seen in brain areas associated with motor and cognitive functions known to be impaired in patients with the 6-OPRI mutation. There were some differences in the anatomical distribution of MTR-VBA and MDVBA changes compared to VBM, likely to reflect regional variations in the type and degree of the respective pathophysiological substrates. Combined analysis of complementary multi-parameter MRI data furthers our understanding of prion disease pathophysiology. PMID:23538406

Distributed Water Pollution Source Localization with Mobile UV-Visible Spectrometer Probes in Wireless Sensor Networks.

PubMed

Ma, Junjie; Meng, Fansheng; Zhou, Yuexi; Wang, Yeyao; Shi, Ping

2018-02-16

Pollution accidents that occur in surface waters, especially in drinking water source areas, greatly threaten the urban water supply system. During water pollution source localization, there are complicated pollutant spreading conditions and pollutant concentrations vary in a wide range. This paper provides a scalable total solution, investigating a distributed localization method in wireless sensor networks equipped with mobile ultraviolet-visible (UV-visible) spectrometer probes. A wireless sensor network is defined for water quality monitoring, where unmanned surface vehicles and buoys serve as mobile and stationary nodes, respectively. Both types of nodes carry UV-visible spectrometer probes to acquire in-situ multiple water quality parameter measurements, in which a self-adaptive optical path mechanism is designed to flexibly adjust the measurement range. A novel distributed algorithm, called Dual-PSO, is proposed to search for the water pollution source, where one particle swarm optimization (PSO) procedure computes the water quality multi-parameter measurements on each node, utilizing UV-visible absorption spectra, and another one finds the global solution of the pollution source position, regarding mobile nodes as particles. Besides, this algorithm uses entropy to dynamically recognize the most sensitive parameter during searching. Experimental results demonstrate that online multi-parameter monitoring of a drinking water source area with a wide dynamic range is achieved by this wireless sensor network and water pollution sources are localized efficiently with low-cost mobile node paths.

Distributed Water Pollution Source Localization with Mobile UV-Visible Spectrometer Probes in Wireless Sensor Networks

PubMed Central

Zhou, Yuexi; Wang, Yeyao; Shi, Ping

2018-01-01

Pollution accidents that occur in surface waters, especially in drinking water source areas, greatly threaten the urban water supply system. During water pollution source localization, there are complicated pollutant spreading conditions and pollutant concentrations vary in a wide range. This paper provides a scalable total solution, investigating a distributed localization method in wireless sensor networks equipped with mobile ultraviolet-visible (UV-visible) spectrometer probes. A wireless sensor network is defined for water quality monitoring, where unmanned surface vehicles and buoys serve as mobile and stationary nodes, respectively. Both types of nodes carry UV-visible spectrometer probes to acquire in-situ multiple water quality parameter measurements, in which a self-adaptive optical path mechanism is designed to flexibly adjust the measurement range. A novel distributed algorithm, called Dual-PSO, is proposed to search for the water pollution source, where one particle swarm optimization (PSO) procedure computes the water quality multi-parameter measurements on each node, utilizing UV-visible absorption spectra, and another one finds the global solution of the pollution source position, regarding mobile nodes as particles. Besides, this algorithm uses entropy to dynamically recognize the most sensitive parameter during searching. Experimental results demonstrate that online multi-parameter monitoring of a drinking water source area with a wide dynamic range is achieved by this wireless sensor network and water pollution sources are localized efficiently with low-cost mobile node paths. PMID:29462929

Multiparameter MR imaging in the 6-OPRI variant of inherited prion disease.

PubMed

De Vita, E; Ridgway, G R; Scahill, R I; Caine, D; Rudge, P; Yousry, T A; Mead, S; Collinge, J; Jäger, H R; Thornton, J S; Hyare, H

2013-09-01

Inherited prion diseases represent over 15% of human prion cases and are a frequent cause of early onset dementia. The purpose of this study was to define the distribution of changes in cerebral volumetric and microstructural parenchymal tissues in a specific inherited human prion disease mutation combining VBM with VBA of cerebral MTR and MD. VBM and VBA of cerebral MTR and MD were performed in 16 healthy control participants and 9 patients with the 6-OPRI mutation. An analysis of covariance consisting of diagnostic grouping with age and total intracranial volume as covariates was performed. On VBM, there was a significant reduction in gray matter volume in patients compared with control participants in the basal ganglia, perisylvian cortex, lingual gyrus, and precuneus. Significant MTR reduction and MD increases were more anatomically extensive than volume differences on VBM in the same cortical areas, but MTR and MD changes were not seen in the basal ganglia. Gray matter and WM changes were seen in brain areas associated with motor and cognitive functions known to be impaired in patients with the 6-OPRI mutation. There were some differences in the anatomic distribution of MTR-VBA and MD-VBA changes compared with VBM, likely to reflect regional variations in the type and degree of the respective pathophysiologic substrates. Combined analysis of complementary multiparameter MR imaging data furthers our understanding of prion disease pathophysiology.

A multi-parameter optical fiber sensor with interrogation and discrimination capabilities

NASA Astrophysics Data System (ADS)

Zhan, Yage; Wu, Hua; Yang, Qinyu; Pei, Jincheng; Yang, Xichun

2009-11-01

A multi-parameter and multi-function, but low-cost, optical fiber grating sensor with self-interrogation and self-discrimination capabilities is presented theoretically and experimentally. The sensor bases on three fiber Bragg gratings (FBG) and one fiber long period grating (LPG). Strain, vibration, pressure, ordinary temperature (-10 to 100 °C) and high temperature (100-800 °C) can be measured by the sensor. When high temperature (100-800 °C) is measured, the LPG is used as a high temperture sensor head and FBG 1 is used as an interrogation element. Alternatively, when one of the other four measurands is measured, FBG 1 (or FBG 2) is used as a sensor head and LPG is used as an interrogation element. When two of the other four measurands are measured simultaneously, FBG 1 and FBG 2 are used as sensor heads and LPG is used as a shared interrogation element. FBG 3 is used as a reference element to eliminate the errors resulted from light source fluctuation and the cross-sensitivity between measurand and environmental temperature. The measurands can be interrogated according to the signals of the photodiodes (PDs), which are related to the relative wavelength shift of the LPG and the FBGs. Experimental results agree well with theoretical analyses. The interrogation scheme is immune to light source fluctuation and the cross-sensitivity between measurands and enviromental temperature, and also the dynamic range is large.

AZA-MS: a novel multiparameter mass spectrometry method to determine the intracellular dynamics of azacitidine therapy in vivo

PubMed Central

Unnikrishnan, A; Vo, A N Q; Pickford, R; Raftery, M J; Nunez, A C; Verma, A; Hesson, L B; Pimanda, J E

2018-01-01

The cytidine analogue, 5-azacytidine (AZA; 5-AZA-cR), is the primary treatment for myelodysplastic syndrome and chronic myelomonocytic leukaemia. However, only ~50% of treated patients will respond to AZA and the drivers of AZA resistance in vivo are poorly understood. To better understand the intracellular dynamics of AZA upon therapy and decipher the molecular basis for AZA resistance, we have developed a novel, multiparameter, quantitative mass spectrometry method (AZA-MS). Using AZA-MS, we have accurately quantified the abundance of the ribonucleoside (5-AZA-cR) and deoxyribonucleoside (5-AZA-CdR) forms of AZA in RNA, DNA and the cytoplasm within the same sample using nanogram quantities of input material. We report that although AZA induces DNA demethylation in a dose-dependent manner, it has no corresponding effect on RNA methylation. By applying AZA-MS to primary bone marrow samples from patients undergoing AZA therapy, we have identified that responders accumulate more 5-AZA-CdR in their DNA compared with nonresponders. AZA resistance was not a result of impaired AZA metabolism or intracellular accumulation. Furthermore, AZA-MS has helped to uncover different modes of AZA resistance. Whereas some nonresponders fail to incorporate sufficient 5-AZA-CdR into DNA, others incorporate 5-AZA-CdR and effect DNA demethylation like AZA responders, but show no clinical benefit. PMID:29249821

Characterisation of capacitive field-effect sensors with a nanocrystalline-diamond film as transducer material for multi-parameter sensing.

PubMed

Abouzar, M H; Poghossian, A; Razavi, A; Williams, O A; Bijnens, N; Wagner, P; Schöning, M J

2009-01-01

The feasibility of a capacitive field-effect EDIS (electrolyte-diamond-insulator-semiconductor) platform for multi-parameter sensing is demonstrated by realising EDIS sensors with an O-terminated nanocrystalline-diamond (NCD) film as transducer material for the detection of pH and penicillin concentration as well as for the label-free electrical monitoring of adsorption and binding of charged macromolecules, like polyelectrolytes. The NCD films were grown on p-Si-SiO(2) substrates by microwave plasma-enhanced chemical vapour deposition. To obtain O-terminated surfaces, the NCD films were treated in an oxidising medium. The NCD-based field-effect sensors have been characterised by means of constant-capacitance method. The average pH sensitivity of the O-terminated NCD film was 40 mV/pH. A low detection limit of 5 microM and a high penicillin G sensitivity of 65-70 mV/decade has been obtained for an EDIS penicillin biosensor with the adsorptively immobilised enzyme penicillinase. Alternating potential changes, having tendency to decrease with increasing the number of adsorbed polyelectrolyte layers, have been observed after the layer-by-layer deposition of polyelectrolyte multilayers, using positively charged PAH (poly (allylamine hydrochloride)) and a negatively charged PSS (poly (sodium 4-styrene sulfonate)) as a model system. The response mechanism of the developed EDIS sensors is discussed.

Single-molecule multiparameter fluorescence spectroscopy reveals directional MutS binding to mismatched bases in DNA

PubMed Central

Cristóvão, Michele; Sisamakis, Evangelos; Hingorani, Manju M.; Marx, Andreas D.; Jung, Caroline P.; Rothwell, Paul J.; Seidel, Claus A. M.; Friedhoff, Peter

2012-01-01

Mismatch repair (MMR) corrects replication errors such as mismatched bases and loops in DNA. The evolutionarily conserved dimeric MMR protein MutS recognizes mismatches by stacking a phenylalanine of one subunit against one base of the mismatched pair. In all crystal structures of G:T mismatch-bound MutS, phenylalanine is stacked against thymine. To explore whether these structures reflect directional mismatch recognition by MutS, we monitored the orientation of Escherichia coli MutS binding to mismatches by FRET and anisotropy with steady state, pre-steady state and single-molecule multiparameter fluorescence measurements in a solution. The results confirm that specifically bound MutS bends DNA at the mismatch. We found additional MutS–mismatch complexes with distinct conformations that may have functional relevance in MMR. The analysis of individual binding events reveal significant bias in MutS orientation on asymmetric mismatches (G:T versus T:G, A:C versus C:A), but not on symmetric mismatches (G:G). When MutS is blocked from binding a mismatch in the preferred orientation by positioning asymmetric mismatches near the ends of linear DNA substrates, its ability to authorize subsequent steps of MMR, such as MutH endonuclease activation, is almost abolished. These findings shed light on prerequisites for MutS interactions with other MMR proteins for repairing the appropriate DNA strand. PMID:22367846

Open-access MIMIC-II database for intensive care research.

PubMed

Lee, Joon; Scott, Daniel J; Villarroel, Mauricio; Clifford, Gari D; Saeed, Mohammed; Mark, Roger G

2011-01-01

The critical state of intensive care unit (ICU) patients demands close monitoring, and as a result a large volume of multi-parameter data is collected continuously. This represents a unique opportunity for researchers interested in clinical data mining. We sought to foster a more transparent and efficient intensive care research community by building a publicly available ICU database, namely Multiparameter Intelligent Monitoring in Intensive Care II (MIMIC-II). The data harnessed in MIMIC-II were collected from the ICUs of Beth Israel Deaconess Medical Center from 2001 to 2008 and represent 26,870 adult hospital admissions (version 2.6). MIMIC-II consists of two major components: clinical data and physiological waveforms. The clinical data, which include patient demographics, intravenous medication drip rates, and laboratory test results, were organized into a relational database. The physiological waveforms, including 125 Hz signals recorded at bedside and corresponding vital signs, were stored in an open-source format. MIMIC-II data were also deidentified in order to remove protected health information. Any interested researcher can gain access to MIMIC-II free of charge after signing a data use agreement and completing human subjects training. MIMIC-II can support a wide variety of research studies, ranging from the development of clinical decision support algorithms to retrospective clinical studies. We anticipate that MIMIC-II will be an invaluable resource for intensive care research by stimulating fair comparisons among different studies.

Associative image analysis: a method for automated quantification of 3D multi-parameter images of brain tissue

PubMed Central

Bjornsson, Christopher S; Lin, Gang; Al-Kofahi, Yousef; Narayanaswamy, Arunachalam; Smith, Karen L; Shain, William; Roysam, Badrinath

2009-01-01

Brain structural complexity has confounded prior efforts to extract quantitative image-based measurements. We present a systematic ‘divide and conquer’ methodology for analyzing three-dimensional (3D) multi-parameter images of brain tissue to delineate and classify key structures, and compute quantitative associations among them. To demonstrate the method, thick (~100 μm) slices of rat brain tissue were labeled using 3 – 5 fluorescent signals, and imaged using spectral confocal microscopy and unmixing algorithms. Automated 3D segmentation and tracing algorithms were used to delineate cell nuclei, vasculature, and cell processes. From these segmentations, a set of 23 intrinsic and 8 associative image-based measurements was computed for each cell. These features were used to classify astrocytes, microglia, neurons, and endothelial cells. Associations among cells and between cells and vasculature were computed and represented as graphical networks to enable further analysis. The automated results were validated using a graphical interface that permits investigator inspection and corrective editing of each cell in 3D. Nuclear counting accuracy was >89%, and cell classification accuracy ranged from 81–92% depending on cell type. We present a software system named FARSIGHT implementing our methodology. Its output is a detailed XML file containing measurements that may be used for diverse quantitative hypothesis-driven and exploratory studies of the central nervous system. PMID:18294697

Flow cytometric HyPer-based assay for hydrogen peroxide.

PubMed

Lyublinskaya, O G; Antonov, S A; Gorokhovtsev, S G; Pugovkina, N A; Kornienko, Ju S; Ivanova, Ju S; Shatrova, A N; Aksenov, N D; Zenin, V V; Nikolsky, N N

2018-05-30

HyPer is a genetically encoded fluorogenic sensor for hydrogen peroxide which is generally used for the ratiometric imaging of H 2 O 2 fluxes in living cells. Here, we demonstrate the advantages of HyPer-based ratiometric flow cytometry assay for H 2 O 2 , by using K562 and human mesenchymal stem cell lines expressing HyPer. We show that flow cytometry analysis is suitable to detect HyPer response to submicromolar concentrations of extracellularly added H 2 O 2 that is much lower than concentrations addressed previously in the other HyPer-based assays (such as cell imaging or fluorimetry). Suggested technique is also much more sensitive to hydrogen peroxide than the widespread flow cytometry assay exploiting H 2 O 2 -reactive dye H 2 DCFDA and, contrary to the H 2 DCFDA-based assay, can be employed for the kinetic studies of H 2 O 2 utilization by cells, including measurements of the rate constants of H 2 O 2 removal. In addition, flow cytometry multi-parameter ratiometric measurements enable rapid and high-throughput detection of endogenously generated H 2 O 2 in different subpopulations of HyPer-expressing cells. To sum up, HyPer can be used in multi-parameter flow cytometry studies as a highly sensitive indicator of intracellular H 2 O 2 . Copyright © 2018. Published by Elsevier Inc.

Real time reconstruction of quasiperiodic multi parameter physiological signals

NASA Astrophysics Data System (ADS)

Ganeshapillai, Gartheeban; Guttag, John

2012-12-01

A modern intensive care unit (ICU) has automated analysis systems that depend on continuous uninterrupted real time monitoring of physiological signals such as electrocardiogram (ECG), arterial blood pressure (ABP), and photo-plethysmogram (PPG). These signals are often corrupted by noise, artifacts, and missing data. We present an automated learning framework for real time reconstruction of corrupted multi-parameter nonstationary quasiperiodic physiological signals. The key idea is to learn a patient-specific model of the relationships between signals, and then reconstruct corrupted segments using the information available in correlated signals. We evaluated our method on MIT-BIH arrhythmia data, a two-channel ECG dataset with many clinically significant arrhythmias, and on the CinC challenge 2010 data, a multi-parameter dataset containing ECG, ABP, and PPG. For each, we evaluated both the residual distance between the original signals and the reconstructed signals, and the performance of a heartbeat classifier on a reconstructed ECG signal. At an SNR of 0 dB, the average residual distance on the CinC data was roughly 3% of the energy in the signal, and on the arrhythmia database it was roughly 16%. The difference is attributable to the large amount of diversity in the arrhythmia database. Remarkably, despite the relatively high residual difference, the classification accuracy on the arrhythmia database was still 98%, indicating that our method restored the physiologically important aspects of the signal.

Community-Based Instruction: Its Origin and Description.

ERIC Educational Resources Information Center

Csapo, Marg

This book chapter puts community-based rehabilitation and community-based instruction in an historical perspective by describing a number of influential social, political, legal, technological, and philosophical factors that have shaped contemporary special and regular education. The characteristics of community-based instruction, community-based…

Gradient Space under Orthography and Perspective

DTIC Science & Technology

1982-05-24

surfaceorientation to image geometry [8, 9, 10, 13, 15]. The descriptions of important gradient space properties, however, have been scattered throughout...Kanade, T. A Theory of Origami World. Artificial Intelligence 13:279-311, 1980. *[8] Kanade, T. and Kender, J. Mapping Image Properies into Shape

User's manual for three dimensional FDTD version D code for scattering from frequency-dependent dielectric and magnetic materials

NASA Technical Reports Server (NTRS)

Beggs, John H.; Luebbers, Raymond J.; Kunz, Karl S.

1992-01-01

The Penn State Finite Difference Time Domain Electromagnetic Scattering Code version D is a 3-D numerical electromagnetic scattering code based upon the finite difference time domain technique (FDTD). The manual provides a description of the code and corresponding results for several scattering problems. The manual is organized into 14 sections: introduction; description of the FDTD method; operation; resource requirements; version D code capabilities; a brief description of the default scattering geometry; a brief description of each subroutine; a description of the include file; a section briefly discussing Radar Cross Section computations; a section discussing some scattering results; a sample problem setup section; a new problem checklist; references and figure titles. The FDTD technique models transient electromagnetic scattering and interactions with objects of arbitrary shape and/or material composition. In the FDTD method, Maxwell's curl equations are discretized in time-space and all derivatives (temporal and spatial) are approximated by central differences.

A novel fruit shape classification method based on multi-scale analysis

NASA Astrophysics Data System (ADS)

Gui, Jiangsheng; Ying, Yibin; Rao, Xiuqin

2005-11-01

Shape is one of the major concerns and which is still a difficult problem in automated inspection and sorting of fruits. In this research, we proposed the multi-scale energy distribution (MSED) for object shape description, the relationship between objects shape and its boundary energy distribution at multi-scale was explored for shape extraction. MSED offers not only the mainly energy which represent primary shape information at the lower scales, but also subordinate energy which represent local shape information at higher differential scales. Thus, it provides a natural tool for multi resolution representation and can be used as a feature for shape classification. We addressed the three main processing steps in the MSED-based shape classification. They are namely, 1) image preprocessing and citrus shape extraction, 2) shape resample and shape feature normalization, 3) energy decomposition by wavelet and classification by BP neural network. Hereinto, shape resample is resample 256 boundary pixel from a curve which is approximated original boundary by using cubic spline in order to get uniform raw data. A probability function was defined and an effective method to select a start point was given through maximal expectation, which overcame the inconvenience of traditional methods in order to have a property of rotation invariants. The experiment result is relatively well normal citrus and serious abnormality, with a classification rate superior to 91.2%. The global correct classification rate is 89.77%, and our method is more effective than traditional method. The global result can meet the request of fruit grading.

Estimating the spatial distribution of soil organic matter density and geochemical properties in a polygonal shaped Arctic Tundra using core sample analysis and X-ray computed tomography

NASA Astrophysics Data System (ADS)

Soom, F.; Ulrich, C.; Dafflon, B.; Wu, Y.; Kneafsey, T. J.; López, R. D.; Peterson, J.; Hubbard, S. S.

2016-12-01

The Arctic tundra with its permafrost dominated soils is one of the regions most affected by global climate change, and in turn, can also influence the changing climate through biogeochemical processes, including greenhouse gas release or storage. Characterization of shallow permafrost distribution and characteristics are required for predicting ecosystem feedbacks to a changing climate over decadal to century timescales, because they can drive active layer deepening and land surface deformation, which in turn can significantly affect hydrological and biogeochemical responses, including greenhouse gas dynamics. In this study, part of the Next-Generation Ecosystem Experiment (NGEE-Arctic), we use X-ray computed tomography (CT) to estimate wet bulk density of cores extracted from a field site near Barrow AK, which extend 2-3m through the active layer into the permafrost. We use multi-dimensional relationships inferred from destructive core sample analysis to infer organic matter density, dry bulk density and ice content, along with some geochemical properties from nondestructive CT-scans along the entire length of the cores, which was not obtained by the spatially limited destructive laboratory analysis. Multi-parameter cross-correlations showed good agreement between soil properties estimated from CT scans versus properties obtained through destructive sampling. Soil properties estimated from cores located in different types of polygons provide valuable information about the vertical distribution of soil and permafrost properties as a function of geomorphology.

The problem with coal-waste dumps inventory in Upper Silesian Coal Basin

NASA Astrophysics Data System (ADS)

Abramowicz, Anna; Chybiorz, Ryszard

2017-04-01

Coal-waste dumps are the side effect of coal mining, which has lasted in Poland for 250 years. They have negative influence on the landscape and the environment, and pollute soil, vegetation and groundwater. Their number, size and shape is changing over time, as new wastes have been produced and deposited changing their shape and enlarging their size. Moreover deposited wastes, especially overburned, are exploited for example road construction, also causing the shape and size change up to disappearing. Many databases and inventory systems were created in order to control these hazards, but some disadvantages prevent reliable statistics. Three representative databases were analyzed according to their structure and type of waste dumps description, classification and visualization. The main problem is correct classification of dumps in terms of their name and type. An additional difficulty is the accurate quantitative description (area and capacity). A complex database was created as a result of comparison, verification of the information contained in existing databases and its supplementation based on separate documentation. A variability analysis of coal-waste dumps over time is also included. The project has been financed from the funds of the Leading National Research Centre (KNOW) received by the Centre for Polar Studies for the period 2014-2018.

DIATOM (Data Initialization and Modification) Library Version 7.0

DOE Office of Scientific and Technical Information (OSTI.GOV)

Crawford, David A.; Schmitt, Robert G.; Hensinger, David M.

DIATOM is a library that provides numerical simulation software with a computational geometry front end that can be used to build up complex problem geometries from collections of simpler shapes. The library provides a parser which allows for application-independent geometry descriptions to be embedded in simulation software input decks. Descriptions take the form of collections of primitive shapes and/or CAD input files and material properties that can be used to describe complex spatial and temporal distributions of numerical quantities (often called “database variables” or “fields”) to help define starting conditions for numerical simulations. The capability is designed to be generalmore » purpose, robust and computationally efficient. By using a combination of computational geometry and recursive divide-and-conquer approximation techniques, a wide range of primitive shapes are supported to arbitrary degrees of fidelity, controllable through user input and limited only by machine resources. Through the use of call-back functions, numerical simulation software can request the value of a field at any time or location in the problem domain. Typically, this is used only for defining initial conditions, but the capability is not limited to just that use. The most recent version of DIATOM provides the ability to import the solution field from one numerical solution as input for another.« less

Global optimization framework for solar building design

NASA Astrophysics Data System (ADS)

Silva, N.; Alves, N.; Pascoal-Faria, P.

2017-07-01

The generative modeling paradigm is a shift from static models to flexible models. It describes a modeling process using functions, methods and operators. The result is an algorithmic description of the construction process. Each evaluation of such an algorithm creates a model instance, which depends on its input parameters (width, height, volume, roof angle, orientation, location). These values are normally chosen according to aesthetic aspects and style. In this study, the model's parameters are automatically generated according to an objective function. A generative model can be optimized according to its parameters, in this way, the best solution for a constrained problem is determined. Besides the establishment of an overall framework design, this work consists on the identification of different building shapes and their main parameters, the creation of an algorithmic description for these main shapes and the formulation of the objective function, respecting a building's energy consumption (solar energy, heating and insulation). Additionally, the conception of an optimization pipeline, combining an energy calculation tool with a geometric scripting engine is presented. The methods developed leads to an automated and optimized 3D shape generation for the projected building (based on the desired conditions and according to specific constrains). The approach proposed will help in the construction of real buildings that account for less energy consumption and for a more sustainable world.

Preliminary Investigation of Ice Shape Sensitivity to Parameter Variations

NASA Technical Reports Server (NTRS)

Miller, Dean R.; Potapczuk, Mark G.; Langhals, Tammy J.

2005-01-01

A parameter sensitivity study was conducted at the NASA Glenn Research Center's Icing Research Tunnel (IRT) using a 36 in. chord (0.91 m) NACA-0012 airfoil. The objective of this preliminary work was to investigate the feasibility of using ice shape feature changes to define requirements for the simulation and measurement of SLD icing conditions. It was desired to identify the minimum change (threshold) in a parameter value, which yielded an observable change in the ice shape. Liquid Water Content (LWC), drop size distribution (MVD), and tunnel static temperature were varied about a nominal value, and the effects of these parameter changes on the resulting ice shapes were documented. The resulting differences in ice shapes were compared on the basis of qualitative and quantitative criteria (e.g., mass, ice horn thickness, ice horn angle, icing limits, and iced area). This paper will provide a description of the experimental method, present selected experimental results, and conclude with an evaluation of these results, followed by a discussion of recommendations for future research.

An Integrated Approach to Swept Wing Icing Simulation

NASA Technical Reports Server (NTRS)

Potapczuk, Mark G.; Broeren, Andy P.

2017-01-01

This paper describes the various elements of a simulation approach used to develop a database of ice shape geometries and the resulting aerodynamic performance data for a representative commercial transport wing model exposed to a variety of icing conditions. This effort included testing in the NASA Icing Research Tunnel, the Wichita State University Walter H. Beech Wind Tunnel, and the ONERA F1 Subsonic Wind Tunnel as well as the use of ice accretion codes, an inviscid design code, and computational fluid dynamics codes. Additionally, methods for capturing full three-dimensional ice shape geometries, geometry interpolation along the span of the wing, and creation of artificial ice shapes based upon that geometric data were developed for this effort. The icing conditions used for this effort were representative of actual ice shape encounter scenarios and run the gamut from ice roughness to full three-dimensional scalloped ice shapes. The effort is still underway so this paper is a status report of work accomplished to date and a description of the remaining elements of the effort.

Refining image segmentation by polygon skeletonization

NASA Technical Reports Server (NTRS)

Clarke, Keith C.

1987-01-01

A skeletonization algorithm was encoded and applied to a test data set of land-use polygons taken from a USGS digital land use dataset at 1:250,000. The distance transform produced by this method was instrumental in the description of the shape, size, and level of generalization of the outlines of the polygons. A comparison of the topology of skeletons for forested wetlands and lakes indicated that some distinction based solely upon the shape properties of the areas is possible, and may be of use in an intelligent automated land cover classification system.

Multiple Coulomb scattering in thin silicon

NASA Astrophysics Data System (ADS)

Berger, N.; Buniatyan, A.; Eckert, P.; Förster, F.; Gredig, R.; Kovalenko, O.; Kiehn, M.; Philipp, R.; Schöning, A.; Wiedner, D.

2014-07-01

We present a measurement of multiple Coulomb scattering of 1 to 6 GeV/c electrons in thin (50-140 μm) silicon targets. The data were obtained with the EUDET telescope Aconite at DESY and are compared to parametrisations as used in the Geant4 software package. We find good agreement between data and simulation in the scattering distribution width but large deviations in the shape of the distribution. In order to achieve a better description of the shape, a new scattering model based on a Student's t distribution is developed and compared to the data.

User's Manual for Computer Program ROTOR. [to calculate tilt-rotor aircraft dynamic characteristics

NASA Technical Reports Server (NTRS)

Yasue, M.

1974-01-01

A detailed description of a computer program to calculate tilt-rotor aircraft dynamic characteristics is presented. This program consists of two parts: (1) the natural frequencies and corresponding mode shapes of the rotor blade and wing are developed from structural data (mass distribution and stiffness distribution); and (2) the frequency response (to gust and blade pitch control inputs) and eigenvalues of the tilt-rotor dynamic system, based on the natural frequencies and mode shapes, are derived. Sample problems are included to assist the user.

Description of high-power laser radiation in the paraxial approximation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Milant'ev, V P; Karnilovich, S P; Shaar, Ya N

2015-11-30

We consider the feasibility of an adequate description of a laser pulse of arbitrary shape within the framework of the paraxial approximation. In this approximation, using a parabolic equation and an expansion in the small parameter, expressions are obtained for the field of a sufficiently intense laser radiation given in the form of axially symmetric Hermite – Gaussian beams of arbitrary mode and arbitrary polarisation. It is shown that in the case of sufficiently short pulses, corrections to the transverse components of the laser field are the first-order rather than the secondorder quantities in the expansion in the small parameter.more » The peculiarities of the description of higher-mode Hermite – Gaussian beams are outlined. (light wave transformation)« less

English-Language Writing Instruction in Poland

ERIC Educational Resources Information Center

Reichelt, Melinda

2005-01-01

Second language writing scholars have undertaken descriptions of English-language writing instruction in a variety of international settings, describing the role of various contextual factors in shaping English-language writing instruction. This article describes English-language writing instruction at various levels in Poland, noting how it is…

Overhearing Single and Multiple Perspectives

ERIC Educational Resources Information Center

Fox Tree, Jean E.; Mayer, Sarah A.

2008-01-01

In 2 spontaneous speech experiments, this study found that multiple perspectives improved overhearers' abilities to select abstract shapes from an array, although single-perspective descriptions were more detailed. Prior findings that overhearers performed better when listening in on dialogues (Fox Tree, 1999) can best be understood as an…

Stamping Out Misconceptions.

ERIC Educational Resources Information Center

Bradley, J. D.; Brand, M.

1985-01-01

Describes the use of rubber hand-stamps to generate molecular pictures. These stamps (prepared with shapes of atoms and molecules at little cost by small, local print shops) can be used in creating pictures representing the microscopic state that can be linked to macroscopic descriptions for active conceptual exploration. (JN)

A semi-analytical bearing model considering outer race flexibility for model based bearing load monitoring

NASA Astrophysics Data System (ADS)

Kerst, Stijn; Shyrokau, Barys; Holweg, Edward

2018-05-01

This paper proposes a novel semi-analytical bearing model addressing flexibility of the bearing outer race structure. It furthermore presents the application of this model in a bearing load condition monitoring approach. The bearing model is developed as current computational low cost bearing models fail to provide an accurate description of the more and more common flexible size and weight optimized bearing designs due to their assumptions of rigidity. In the proposed bearing model raceway flexibility is described by the use of static deformation shapes. The excitation of the deformation shapes is calculated based on the modelled rolling element loads and a Fourier series based compliance approximation. The resulting model is computational low cost and provides an accurate description of the rolling element loads for flexible outer raceway structures. The latter is validated by a simulation-based comparison study with a well-established bearing simulation software tool. An experimental study finally shows the potential of the proposed model in a bearing load monitoring approach.

Cell mechanics: a dialogue.

PubMed

Tao, Jiaxiang; Li, Yizeng; Vig, Dhruv K; Sun, Sean X

2017-03-01

Under the microscope, eukaryotic animal cells can adopt a variety of different shapes and sizes. These cells also move and deform, and the physical mechanisms driving these movements and shape changes are important in fundamental cell biology, tissue mechanics, as well as disease biology. This article reviews some of the basic mechanical concepts in cells, emphasizing continuum mechanics description of cytoskeletal networks and hydrodynamic flows across the cell membrane. We discuss how cells can generate movement and shape changes by controlling mass fluxes at the cell boundary. These mass fluxes can come from polymerization/depolymerization of actin cytoskeleton, as well as osmotic and hydraulic pressure-driven flow of water across the cell membrane. By combining hydraulic pressure control with force balance conditions at the cell surface, we discuss a quantitative mechanism of cell shape and volume control. The broad consequences of this model on cell mechanosensation and tissue mechanics are outlined.

Cell mechanics: a dialogue

PubMed Central

Tao, Jiaxiang; Li, Yizeng; Vig, Dhruv K; Sun, Sean X

2017-01-01

Under the microscope, eukaryotic animal cells can adopt a variety of different shapes and sizes. These cells also move and deform, and the physical mechanisms driving these movements and shape changes are important in fundamental cell biology, tissue mechanics, as well as disease biology. This article reviews some of the basic mechanical concepts in cells, emphasizing continuum mechanics description of cytoskeletal networks and hydrodynamic flows across the cell membrane. We discuss how cells can generate movement and shape changes by controlling mass fluxes at the cell boundary. These mass fluxes can come from polymerization/depolymerization of actin cytoskeleton, as well as osmotic and hydraulic pressure-driven flow of water across the cell membrane. By combining hydraulic pressure control with force balance conditions at the cell surface, we discuss a quantitative mechanism of cell shape and volume control. The broad consequences of this model on cell mechanosensation and tissue mechanics are outlined. PMID:28129208

Cell mechanics: a dialogue

NASA Astrophysics Data System (ADS)

Tao, Jiaxiang; Li, Yizeng; Vig, Dhruv K.; Sun, Sean X.

2017-03-01

Under the microscope, eukaryotic animal cells can adopt a variety of different shapes and sizes. These cells also move and deform, and the physical mechanisms driving these movements and shape changes are important in fundamental cell biology, tissue mechanics, as well as disease biology. This article reviews some of the basic mechanical concepts in cells, emphasizing continuum mechanics description of cytoskeletal networks and hydrodynamic flows across the cell membrane. We discuss how cells can generate movement and shape changes by controlling mass fluxes at the cell boundary. These mass fluxes can come from polymerization/depolymerization of actin cytoskeleton, as well as osmotic and hydraulic pressure-driven flow of water across the cell membrane. By combining hydraulic pressure control with force balance conditions at the cell surface, we discuss a quantitative mechanism of cell shape and volume control. The broad consequences of this model on cell mechanosensation and tissue mechanics are outlined.

Removal of central obscuration and spider arm effects with beam-shaping coronagraphy

NASA Astrophysics Data System (ADS)

Abe, L.; Murakami, N.; Nishikawa, J.; Tamura, M.

2006-05-01

This paper describes a method for removing the effect of a centrally obscured aperture with additional spider arms in arbitrary geometrical configurations. The proposed method is based on a two-stage process where the light beam is first shaped to remove the central obscuration and spider arms, in order to feed a second, highly efficient coronagraph. The beam-shaping stage is a combination of a diffraction mask in the first focal plane and a complex amplitude filter located in the conjugate pupil. This paper specifically describes the case of using Lyot occulting masks and circular phase-shifting masks as diffracting components. The basic principle of the method is given along with an analytical description and numerical simulations. Substantial improvement in the performance of high-contrast coronagraphs can be obtained with this method, even if the beam-shaping filter is not perfectly manufactured.

Topological Aspects of the FAITH Experiment

NASA Technical Reports Server (NTRS)

Tobak, Murray; Long, Kurtis

2010-01-01

This slide presentation reviews the following issues (1) What is relationship between surface pressure extrema and singular points? (2) Does every singular point in a pattern of skin friction lines occur at a surface pressure extremum? (and/or vice versa?) (3) Can this relationship be generalized to all geometries? (4) FAITH Project (5) Ongoing effort at NASA Ames Experimental AeroPhysics Branch (6) Multi-parameter wind tunnel investigation of flow around obstacle (7) Acquire data for CFD validation, optimization and (8) Relationship between FAITH and topology projects

Combining the bi-Yang-Baxter deformation, the Wess-Zumino term and TsT transformations in one integrable σ-model

NASA Astrophysics Data System (ADS)

Delduc, F.; Hoare, B.; Kameyama, T.; Magro, M.

2017-10-01

A multi-parameter integrable deformation of the principal chiral model is presented. The Yang-Baxter and bi-Yang-Baxter σ-models, the principal chiral model plus a Wess-Zumino term and the TsT transformation of the principal chiral model are all recovered when the appropriate deformation parameters vanish. When the Lie group is SU(2), we show that this four-parameter integrable deformation of the SU(2) principal chiral model corresponds to the Lukyanov model.

A Unified Approach to Electromagnetic Wave Propagation in Turbulence and the Evaluation of Multiparameter Integrals

DTIC Science & Technology

1988-07-01

The solutions in some cases have been made more general , as in the papers of Fried2 and Tyler3 by defining normnalized quantities; the tabular and... generalized hypergeometric functions. For that case, he shows that the integral, which can be transformed into a Mellin- Barnes integral, can be expressed as a...finite sum of generalized hypergeometric functions which are equivalent to a Meijer’s G-function. He briefly considers the case in which the

Stability, performance and sensitivity analysis of I.I.D. jump linear systems

NASA Astrophysics Data System (ADS)

Chávez Fuentes, Jorge R.; González, Oscar R.; Gray, W. Steven

2018-06-01

This paper presents a symmetric Kronecker product analysis of independent and identically distributed jump linear systems to develop new, lower dimensional equations for the stability and performance analysis of this type of systems than what is currently available. In addition, new closed form expressions characterising multi-parameter relative sensitivity functions for performance metrics are introduced. The analysis technique is illustrated with a distributed fault-tolerant flight control example where the communication links are allowed to fail randomly.

Multiparameter Flow Cytometry For Clinical Applications

NASA Astrophysics Data System (ADS)

Stewart, Carleton C.

1989-06-01

Flow Cytometry facilities are well established and provide immunophenotyping and DNA content measurement services. The application of immunophenotyping has been primarily in monitoring therapy and in providing further information to aid in the definitive diagnosis of immunological and neoplastic disease such as: immunodeficiency disease, auto immune disease, organ transplantation, and leukemia and lymphoma. DNA content measurements have been particularly important in determining the fraction of cycling cells and presence of aneuploid cells in neoplasia. This information has been useful in the management of patients with solid tumors.

NASA Applications of Structural Health Monitoring Technology

NASA Technical Reports Server (NTRS)

Richards, W Lance; Madaras, Eric I.; Prosser, William H.; Studor, George

2013-01-01

This presentation provides examples of research and development that has recently or is currently being conducted at NASA, with a special emphasis on the application of structural health monitoring (SHM) of aerospace vehicles. SHM applications on several vehicle programs are highlighted, including Space Shuttle Orbiter, International Space Station, Uninhabited Aerial Vehicles, and Expandable Launch Vehicles. Examples of current and previous work are presented in the following categories: acoustic emission impact detection, multi-parameter fiber optic strain-based sensing, wireless sensor system development, and distributed leak detection.

NASA Applications of Structural Health Monitoring Technology

NASA Technical Reports Server (NTRS)

Richards, W Lance; Madaras, Eric I.; Prosser, William H.; Studor, George

2013-01-01

This presentation provides examples of research and development that has recently or is currently being conducted at NASA, with a special emphasis on the application of structural health monitoring (SHM) of aerospace vehicles. SHM applications on several vehicle programs are highlighted, including Space Shuttle Orbiter, the International Space Station, Uninhabited Aerial Vehicles, and Expendable Launch Vehicles. Examples of current and previous work are presented in the following categories: acoustic emission impact detection, multi-parameter fiber optic strain-based sensing, wireless sensor system development, and distributed leak detection.

Extracting falsifiable predictions from sloppy models.

PubMed

Gutenkunst, Ryan N; Casey, Fergal P; Waterfall, Joshua J; Myers, Christopher R; Sethna, James P

2007-12-01

Successful predictions are among the most compelling validations of any model. Extracting falsifiable predictions from nonlinear multiparameter models is complicated by the fact that such models are commonly sloppy, possessing sensitivities to different parameter combinations that range over many decades. Here we discuss how sloppiness affects the sorts of data that best constrain model predictions, makes linear uncertainty approximations dangerous, and introduces computational difficulties in Monte-Carlo uncertainty analysis. We also present a useful test problem and suggest refinements to the standards by which models are communicated.

Effect of Obesity and Chronic Inflammation on TRAIL-Based Immunotherapy for Advanced Breast Cancer

DTIC Science & Technology

2015-04-01

resistance. J Clin Invest, 112: 1821, 2003 3. Lee, I. S., Shin, G., Choue, R.: Shifts in diet from high fat to high carbohydrate improved levels of...phenotype and percentages via multiparameter flow cytometry – months 10-13 (Dr. Norian) B. Evaluate shifts in DC stimulatory vs . regulatory function...cohort of 13 NW and 13 DIO mice is shown in Fig. 1B. Compared to NW mice, DIO mice had increased percentages of visceral body fat and increased

Effect of Obesity and Chronic Inflammation on TRAIL-Based Immunotherapy for Advanced Breast Cancer

DTIC Science & Technology

2014-04-01

to high carbohydrate improved levels of adipokines and pro-inflammatory cytokines in mice fed a high- fat diet. Endocr J, 57: 39, 2009 4. Fenton, J...phenotype and percentages via multiparameter flow cytometry – months 10-13 (Dr. Norian) B. Evaluate shifts in DC stimulatory vs . regulatory...weights of one cohort of 13 NW and 13 DIO mice is shown in Fig. 1B. Compared to NW mice, DIO mice had increased percentages of visceral body fat and

Nasal Septal Deviations: A Systematic Review of Classification Systems.

PubMed

Teixeira, Jeffrey; Certal, Victor; Chang, Edward T; Camacho, Macario

2016-01-01

Objective. To systematically review the international literature for internal nasal septal deviation classification systems and summarize them for clinical and research purposes. Data Sources. Four databases (including PubMed/MEDLINE) were systematically searched through December 16, 2015. Methods. Systematic review, adhering to PRISMA. Results. After removal of duplicates, this study screened 952 articles for relevance. A final comprehensive review of 50 articles identified that 15 of these articles met the eligibility criteria. The classification systems defined in these articles included C-shaped, S-shaped, reverse C-shaped, and reverse S-shaped descriptions of the septal deviation in both the cephalocaudal and anteroposterior dimensions. Additional studies reported use of computed tomography and categorized deviation based on predefined locations. Three studies graded the severity of septal deviations based on the amount of deflection. The systems defined in the literature also included an evaluation of nasal septal spurs and perforations. Conclusion. This systematic review ascertained that the majority of the currently published classification systems for internal nasal septal deviations can be summarized by C-shaped or reverse C-shaped, as well as S-shaped or reverse S-shaped deviations in the anteroposterior and cephalocaudal dimensions. For imaging studies, predefined points have been defined along the septum. Common terminology can facilitate future research.

Deciphering the shape and deformation of secondary structures through local conformation analysis

PubMed Central

2011-01-01

Background Protein deformation has been extensively analysed through global methods based on RMSD, torsion angles and Principal Components Analysis calculations. Here we use a local approach, able to distinguish among the different backbone conformations within loops, α-helices and β-strands, to address the question of secondary structures' shape variation within proteins and deformation at interface upon complexation. Results Using a structural alphabet, we translated the 3 D structures of large sets of protein-protein complexes into sequences of structural letters. The shape of the secondary structures can be assessed by the structural letters that modeled them in the structural sequences. The distribution analysis of the structural letters in the three protein compartments (surface, core and interface) reveals that secondary structures tend to adopt preferential conformations that differ among the compartments. The local description of secondary structures highlights that curved conformations are preferred on the surface while straight ones are preferred in the core. Interfaces display a mixture of local conformations either preferred in core or surface. The analysis of the structural letters transition occurring between protein-bound and unbound conformations shows that the deformation of secondary structure is tightly linked to the compartment preference of the local conformations. Conclusion The conformation of secondary structures can be further analysed and detailed thanks to a structural alphabet which allows a better description of protein surface, core and interface in terms of secondary structures' shape and deformation. Induced-fit modification tendencies described here should be valuable information to identify and characterize regions under strong structural constraints for functional reasons. PMID:21284872

Deciphering the shape and deformation of secondary structures through local conformation analysis.

PubMed

Baussand, Julie; Camproux, Anne-Claude

2011-02-01

Protein deformation has been extensively analysed through global methods based on RMSD, torsion angles and Principal Components Analysis calculations. Here we use a local approach, able to distinguish among the different backbone conformations within loops, α-helices and β-strands, to address the question of secondary structures' shape variation within proteins and deformation at interface upon complexation. Using a structural alphabet, we translated the 3 D structures of large sets of protein-protein complexes into sequences of structural letters. The shape of the secondary structures can be assessed by the structural letters that modeled them in the structural sequences. The distribution analysis of the structural letters in the three protein compartments (surface, core and interface) reveals that secondary structures tend to adopt preferential conformations that differ among the compartments. The local description of secondary structures highlights that curved conformations are preferred on the surface while straight ones are preferred in the core. Interfaces display a mixture of local conformations either preferred in core or surface. The analysis of the structural letters transition occurring between protein-bound and unbound conformations shows that the deformation of secondary structure is tightly linked to the compartment preference of the local conformations. The conformation of secondary structures can be further analysed and detailed thanks to a structural alphabet which allows a better description of protein surface, core and interface in terms of secondary structures' shape and deformation. Induced-fit modification tendencies described here should be valuable information to identify and characterize regions under strong structural constraints for functional reasons.

Ice Shape Characterization Using Self-Organizing Maps

NASA Technical Reports Server (NTRS)

McClain, Stephen T.; Tino, Peter; Kreeger, Richard E.

2011-01-01

A method for characterizing ice shapes using a self-organizing map (SOM) technique is presented. Self-organizing maps are neural-network techniques for representing noisy, multi-dimensional data aligned along a lower-dimensional and possibly nonlinear manifold. For a large set of noisy data, each element of a finite set of codebook vectors is iteratively moved in the direction of the data closest to the winner codebook vector. Through successive iterations, the codebook vectors begin to align with the trends of the higher-dimensional data. In information processing, the intent of SOM methods is to transmit the codebook vectors, which contains far fewer elements and requires much less memory or bandwidth, than the original noisy data set. When applied to airfoil ice accretion shapes, the properties of the codebook vectors and the statistical nature of the SOM methods allows for a quantitative comparison of experimentally measured mean or average ice shapes to ice shapes predicted using computer codes such as LEWICE. The nature of the codebook vectors also enables grid generation and surface roughness descriptions for use with the discrete-element roughness approach. In the present study, SOM characterizations are applied to a rime ice shape, a glaze ice shape at an angle of attack, a bi-modal glaze ice shape, and a multi-horn glaze ice shape. Improvements and future explorations will be discussed.

Complex Landscape Terms in Seri

ERIC Educational Resources Information Center

O'Meara, Carolyn; Bohnemeyer, Jurgen

2008-01-01

The nominal lexicon of Seri is characterized by a prevalence of analytical descriptive terms. We explore the consequences of this typological trait in the landscape domain. The complex landscape terms of Seri classify geographic entities in terms of their material make-up and spatial properties such as shape, orientation, and merological…

SDL: A Surface Description Language

NASA Technical Reports Server (NTRS)

Maple, Raymond C.

1992-01-01

A new interpreted language specifically designed for surface grid generation is introduced. Many unique aspects of the language are discussed, including the farray, vector, curve, and surface data types and the operators used to manipulate them. Custom subroutine libraries written in the language are used to easily build surface grids for generic missile shapes.

16 CFR 305.3 - Description of covered products.

Code of Federal Regulations, 2010 CFR

2010-01-01

... discharge into light, including only the following: (i) Any straight-shaped lamp (commonly referred to as 4... OTHER PRODUCTS REQUIRED UNDER THE ENERGY POLICY AND CONSERVATION ACT (âAPPLIANCE LABELING RULEâ... refrigerator means a cabinet designed for the refrigerated storage of food at temperatures above 32 °F and...

Mountain Plains Learning Experience Guide: Drafting. Course: Basic Drawing. Revised Edition.

ERIC Educational Resources Information Center

Wetterling, C.; Wheatley, J.

One of two individualized courses included in a drafting curriculum, this course is designed to develop the fundamental skills of drafting using mechanical instruments. The course is comprised of thirteen units: (1) Mechanical Drawing, (2) Lettering, (3) Geometric Construction, (4) Shape Description, (5) Multiview Projection and Drawing…

A Theoretical Trombone

ERIC Educational Resources Information Center

LoPresto, Michael C.

2014-01-01

What follows is a description of a theoretical model designed to calculate the playing frequencies of the musical pitches produced by a trombone. The model is based on quantitative treatments that demonstrate the effects of the flaring bell and cup-shaped mouthpiece sections on these frequencies and can be used to calculate frequencies that…

The Geometry of the Universe: Part 2

ERIC Educational Resources Information Center

Francis, Stephanie

2009-01-01

Hyperbolic geometry occurs on hyperbolic planes--the most commonly cited one being a saddle shape. In this article, the author explores negative hyperbolic curvature, and provides a detailed description of how she constructed two hyperbolic paraboloids. Hyperbolic geometry occurs on surfaces that have negative curvature. (Contains 11 figures and 4…

Symmetry remnants in the face of competing interactions in nuclei

DOE Office of Scientific and Technical Information (OSTI.GOV)

Leviatan, A., E-mail: ami@phys.huji.ac.il; Macek, M., E-mail: michal.macek@yale.edu

2015-10-15

Detailed description of nuclei necessitates model Hamiltonians which break most dynamical symmetries. Nevertheless, generalized notions of partial and quasi dynamical symmetries may still be applicable to selected subsets of states, amidst a complicated environment of other states. We examine such scenarios in the context of nuclear shape-phase transitions.

Exploring the "New" Unionism: Perceptions of Recently Tenured Teachers.

ERIC Educational Resources Information Center

Murray, Christine E.

A study analyzed recently tenured teachers' perceptions about union reform, examining factors shaping their beliefs and noting efforts of Rochester, New York's Rochester Teachers' Association (RTA) to promote reform and foster new leadership. Newly tenured teachers completed interviews on: the RTA's role; a description of the RTA; what influenced…

Public Health and Church-Based Constructions of HIV Prevention: Black Baptist Perspective

ERIC Educational Resources Information Center

Roman Isler, Malika; Eng, Eugenia; Maman, Susanne; Adimora, Adaora; Weiner, Bryan

2014-01-01

The black church is influential in shaping health behaviors within African-American communities, yet few use evidence-based strategies for HIV prevention (abstinence, monogamy, condoms, voluntary counseling and testing, and prevention with positives). Using principles of grounded theory and interpretive description, we explored the social…

A description of discrete internal representation schemes for visual pattern discrimination.

PubMed

Foster, D H

1980-01-01

A general description of a class of schemes for pattern vision is outlined in which the visual system is assumed to form a discrete internal representation of the stimulus. These representations are discrete in that they are considered to comprise finite combinations of "components" which are selected from a fixed and finite repertoire, and which designate certain simple pattern properties or features. In the proposed description it is supposed that the construction of an internal representation is a probabilistic process. A relationship is then formulated associating the probability density functions governing this construction and performance in visually discriminating patterns when differences in pattern shape are small. Some questions related to the application of this relationship to the experimental investigation of discrete internal representations are briefly discussed.

Multi-parameter vital sign database to assist in alarm optimization for general care units.

PubMed

Welch, James; Kanter, Benjamin; Skora, Brooke; McCombie, Scott; Henry, Isaac; McCombie, Devin; Kennedy, Rosemary; Soller, Babs

2016-12-01

Continual vital sign assessment on the general care, medical-surgical floor is expected to provide early indication of patient deterioration and increase the effectiveness of rapid response teams. However, there is concern that continual, multi-parameter vital sign monitoring will produce alarm fatigue. The objective of this study was the development of a methodology to help care teams optimize alarm settings. An on-body wireless monitoring system was used to continually assess heart rate, respiratory rate, SpO 2 and noninvasive blood pressure in the general ward of ten hospitals between April 1, 2014 and January 19, 2015. These data, 94,575 h for 3430 patients are contained in a large database, accessible with cloud computing tools. Simulation scenarios assessed the total alarm rate as a function of threshold and annunciation delay (s). The total alarm rate of ten alarms/patient/day predicted from the cloud-hosted database was the same as the total alarm rate for a 10 day evaluation (1550 h for 36 patients) in an independent hospital. Plots of vital sign distributions in the cloud-hosted database were similar to other large databases published by different authors. The cloud-hosted database can be used to run simulations for various alarm thresholds and annunciation delays to predict the total alarm burden experienced by nursing staff. This methodology might, in the future, be used to help reduce alarm fatigue without sacrificing the ability to continually monitor all vital signs.

Development of an automated analysis system for data from flow cytometric intracellular cytokine staining assays from clinical vaccine trials

PubMed Central

Shulman, Nick; Bellew, Matthew; Snelling, George; Carter, Donald; Huang, Yunda; Li, Hongli; Self, Steven G.; McElrath, M. Juliana; De Rosa, Stephen C.

2008-01-01

Background Intracellular cytokine staining (ICS) by multiparameter flow cytometry is one of the primary methods for determining T cell immunogenicity in HIV-1 clinical vaccine trials. Data analysis requires considerable expertise and time. The amount of data is quickly increasing as more and larger trials are performed, and thus there is a critical need for high throughput methods of data analysis. Methods A web based flow cytometric analysis system, LabKey Flow, was developed for analyses of data from standardized ICS assays. A gating template was created manually in commercially-available flow cytometric analysis software. Using this template, the system automatically compensated and analyzed all data sets. Quality control queries were designed to identify potentially incorrect sample collections. Results Comparison of the semi-automated analysis performed by LabKey Flow and the manual analysis performed using FlowJo software demonstrated excellent concordance (concordance correlation coefficient >0.990). Manual inspection of the analyses performed by LabKey Flow for 8-color ICS data files from several clinical vaccine trials indicates that template gates can appropriately be used for most data sets. Conclusions The semi-automated LabKey Flow analysis system can analyze accurately large ICS data files. Routine use of the system does not require specialized expertise. This high-throughput analysis will provide great utility for rapid evaluation of complex multiparameter flow cytometric measurements collected from large clinical trials. PMID:18615598

Research on multi-parameter monitoring of steel frame shaking-table test using smartphone

NASA Astrophysics Data System (ADS)

Han, Ruicong; Loh, Kenneth J.; Zhao, Xuefeng; Yu, Yan

2017-04-01

The numerical simulation promises an effective method to assess seismic damage of high-rise structure. But it's difficult to determine the input parameters and the simulation results are not completely consistent with the real condition. A more direct approach to evaluate the seismic damage is the structural health monitoring (SHM), which is one complex set of various kinds of sensors, devices and software, and always needs professionals. SHM system has achieved great development over recent years, especially on bridge structures. However it's not so popular on high-rise building due to its difficult implementation. Developing a low-cost and convenient monitoring technique will be helpful for the safety maintenance of high-rise building. Smartphones, which embedded with sensors, network transmission, data storage and processing system, are evolving towards crowdsourcing. The popularity of smartphones presents opportunities for implementation of portable SHM system on buildings. In this paper, multi-parameter monitoring of a three-story steel frame on shaking table under earthquake excitations was conducted with smartphone, and the comparison between smartphone and traditional sensors was provided. First, the monitoring applications on iOS platform, Orion-CC and D-viewer, were introduced. Then the experimental details were presented, including three-story frame model, sensors placement, viscous dampers and so on. Last, the acceleration and displacement time-history curves of smartphone and traditional sensors are provided and compared to prove the feasibility of the monitoring on frame under earthquake excitations by smartphone.

Fabrication of a Miniature Multi-Parameter Sensor Chip for Water Quality Assessment.

PubMed

Zhou, Bo; Bian, Chao; Tong, Jianhua; Xia, Shanhong

2017-01-14

Water contamination is a main inducement of human diseases. It is an important step to monitor the water quality in the water distribution system. Due to the features of large size, high cost, and complicated structure of traditional water determination sensors and devices, it is difficult to realize real-time water monitoring on a large scale. In this paper, we present a multi-parameter sensor chip, which is miniature, low-cost, and robust, to detect the pH, conductivity, and temperature of water simultaneously. The sensor chip was fabricated using micro-electro-mechanical system (MEMS) techniques. Iridium oxide film was electrodeposited as the pH-sensing material. The atomic ratio of Ir(III) to Ir(IV) is about 1.38 according to the X-ray photoelectron spectroscopy (XPS) analysis. The pH sensing electrode showed super-Nernstian response (-67.60 mV/pH) and good linearity (R² = 0.9997), in the range of pH 2.22 to pH 11.81. KCl-agar and epoxy were used as the electrolyte layer and liquid junction for the solid-state reference electrode, respectively, and its potential stability in deionized water was 56 h. The conductivity cell exhibited a linear determination range from 21.43 μ S / cm to 1.99 mS / cm , and the electrode constant was 1.566 cm -1 . Sensitivity of the temperature sensor was 5.46 Ω / ° C . The results indicate that the developed sensor chip has potential application in water quality measurements.

Anti-TNF and thiopurine therapy in pregnant IBD patients does not significantly alter a panel of B-cell and T-cell subsets in 1-year-old infants.

PubMed

Kattah, Michael G; Milush, Jeffrey M; Burt, Trevor; McCabe, Robert P; Whang, Michael I; Ma, Averil; Mahadevan, Uma

2018-04-03

Infants exposed to combination therapy with anti-tumor necrosis factor (anti-TNF) agents and thiopurines may exhibit increased infections at 1 year of age compared to unexposed infants. We hypothesized that this increased risk of infection is due to abnormal development of the newborn immune system. We immunophenotyped B-cell and T-cell subsets using multiparameter flow cytometry in 1-year-old infants whose mothers were exposed to therapeutic agents for IBD. We analyzed samples from infants exposed to infliximab (IFX) or adalimumab (ADA) monotherapy (IFX/ADA, n = 11), certolizumab pegol (CZP) monotherapy (CZP, n = 4), IFX or ADA plus thiopurine combination therapy (IFX/ADA + IM, n = 4), and CZP plus thiopurine combination therapy (CZP + IM, n = 2). Percentages of B cells, CD4 + T helper cells, T regulatory cells (T regs ), and CD8 + cytotoxic T cells, were similar among the groups. Infants exposed to combination therapy (IFX/ADA + IM) exhibited trends toward fewer CD27 + B cells, switched memory B cells, plasmablasts, interferon gamma (IFNγ)-producing CD4 + and CD8 + T cells, and CCR5 + CD4 + T cells, but these did not reach statistical significance. Multiparameter immunophenotyping of major B-cell and T-cell subsets suggests that the adaptive newborn immune system develops largely unaltered after exposure to combination therapy as compared to anti-TNF monotherapy.

Elucidation of Seventeen Human Peripheral Blood B cell Subsets and Quantification of the Tetanus Response Using a Density-Based Method for the Automated Identification of Cell Populations in Multidimensional Flow Cytometry Data

PubMed Central

Qian, Yu; Wei, Chungwen; Lee, F. Eun-Hyung; Campbell, John; Halliley, Jessica; Lee, Jamie A.; Cai, Jennifer; Kong, Megan; Sadat, Eva; Thomson, Elizabeth; Dunn, Patrick; Seegmiller, Adam C.; Karandikar, Nitin J.; Tipton, Chris; Mosmann, Tim; Sanz, Iñaki; Scheuermann, Richard H.

2011-01-01

Background Advances in multi-parameter flow cytometry (FCM) now allow for the independent detection of larger numbers of fluorochromes on individual cells, generating data with increasingly higher dimensionality. The increased complexity of these data has made it difficult to identify cell populations from high-dimensional FCM data using traditional manual gating strategies based on single-color or two-color displays. Methods To address this challenge, we developed a novel program, FLOCK (FLOw Clustering without K), that uses a density-based clustering approach to algorithmically identify biologically relevant cell populations from multiple samples in an unbiased fashion, thereby eliminating operator-dependent variability. Results FLOCK was used to objectively identify seventeen distinct B cell subsets in a human peripheral blood sample and to identify and quantify novel plasmablast subsets responding transiently to tetanus and other vaccinations in peripheral blood. FLOCK has been implemented in the publically available Immunology Database and Analysis Portal – ImmPort (http://www.immport.org) for open use by the immunology research community. Conclusions FLOCK is able to identify cell subsets in experiments that use multi-parameter flow cytometry through an objective, automated computational approach. The use of algorithms like FLOCK for FCM data analysis obviates the need for subjective and labor intensive manual gating to identify and quantify cell subsets. Novel populations identified by these computational approaches can serve as hypotheses for further experimental study. PMID:20839340

Multiparameter double hole contrast detail phantom: Ability to detect image displacement due to off position anode stem

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pauzi, Nur Farahana; Majid, Zafri Azran Abdul; Sapuan, Abdul Halim

Contrast Detail phantom is a quality control tool to analyze the performance of imaging devices. Currently, its function is solely to evaluate the contrast detail characteristic of imaging system. It consists of drilled hole which gives effect to the penetration of x-ray beam divergence to pass through the base of each hole. This effect will lead to false appearance of image from its original location but it does not being visualized in the radiograph. In this study, a new design of Contrast Detail phantom’s hole which consists of double hole construction has been developed. It can detect the image displacementmore » which is due to off position of anode stem from its original location. The double hole differs from previous milled hole, whereby it consists of combination of different hole diameters. Small hole diameter (3 mm) is positioned on top of larger hole diameter (10 mm). The thickness of double hole acrylic blocks is 13 mm. Result revealed that Multiparameter Double Hole Contrast Detail phantom can visualize the shifted flaw image quality produced by x-ray machine due to improper position of the anode stem which is attached to rotor and stator. The effective focal spot of x-ray beam also has been shifted from the center of collimator as a result of off-position anode stem. As a conclusion, the new design of double hole Contrast Detail phantom able to measure those parameters in a well manner.« less

High Frequency and Multi-parameter Observation of Land-Sea Connection at the Aransas Pass Tidal Inlet, South Texas in Summer 2008

NASA Astrophysics Data System (ADS)

Min, D.

2008-12-01

Understanding the nature of water exchange and material transport processes at tidal inlets is critical in improving our knowledge of land-sea connection and exchange processes. High-frequency multi-parameter water property measurement was conducted over a month period during mid-June to mid-July in 2008 at the UT Marine Science Institute pier at Port Aransas, Texas throughout 12-m water column. The pier is at the Aransas Pass tidal inlet, which is a major water and property exchange pathway in South Texas between several local bays and the Gulf of Mexico. Unlike the summer 2007 when a large-scale freshwater discharge event occurred, the summer 2008 during the observation period was relatively dry in general. Offshore influence was more pronounced this year than 2007 with multiple days of higher salinity water (higher than 36 psu) dominating over tidal cycles. The offshore influence was also marked by lower oxygen and chlorophyll concentrations. The lower oxygen content water with higher salinity seems to be connected to low-oxygen bottom water on near shore shelf area. Additional instrument mooring data during hurricane Dolly will also be presented along with the current meter and tide gauge information. Comparison of the data with that observed from nearby Mission-Aransas National Estuarine Research Reserve SWMP stations will be presented as well. Continuous water column measurements at a local inlet show a potential to quantify water property flux and to detect episodic events in the coastal environment.

High dimensional model representation method for fuzzy structural dynamics

NASA Astrophysics Data System (ADS)

Adhikari, S.; Chowdhury, R.; Friswell, M. I.

2011-03-01

Uncertainty propagation in multi-parameter complex structures possess significant computational challenges. This paper investigates the possibility of using the High Dimensional Model Representation (HDMR) approach when uncertain system parameters are modeled using fuzzy variables. In particular, the application of HDMR is proposed for fuzzy finite element analysis of linear dynamical systems. The HDMR expansion is an efficient formulation for high-dimensional mapping in complex systems if the higher order variable correlations are weak, thereby permitting the input-output relationship behavior to be captured by the terms of low-order. The computational effort to determine the expansion functions using the α-cut method scales polynomically with the number of variables rather than exponentially. This logic is based on the fundamental assumption underlying the HDMR representation that only low-order correlations among the input variables are likely to have significant impacts upon the outputs for most high-dimensional complex systems. The proposed method is first illustrated for multi-parameter nonlinear mathematical test functions with fuzzy variables. The method is then integrated with a commercial finite element software (ADINA). Modal analysis of a simplified aircraft wing with fuzzy parameters has been used to illustrate the generality of the proposed approach. In the numerical examples, triangular membership functions have been used and the results have been validated against direct Monte Carlo simulations. It is shown that using the proposed HDMR approach, the number of finite element function calls can be reduced without significantly compromising the accuracy.

Additivity rules using similarity models for chemical reactivity: calculation and interpretation of electrofugality and nucleofugality.

PubMed

Bentley, T William

2006-08-25

A recently proposed, multi-parameter correlation: log k (25 degrees C)=s(f) (Ef + Nf), where Ef is electrofugality and Nf is nucleofugality, for the substituent and solvent effects on the rate constants for solvolyses of benzhydryl and substituted benzhydryl substrates, is re-evaluated. A new formula (Ef=log k (RCl/EtOH/25 degrees C) -1.87), where RCl/EtOH refers to ethanolysis of chlorides, reproduces published values of Ef satisfactorily, avoids multi-parameter optimisations and provides additional values of Ef. From the formula for Ef, it is shown that the term (sfxEf) is compatible with the Hammett-Brown (rho+sigma+) equation for substituent effects. However, the previously published values of N(f) do not accurately account for solvent and leaving group effects (e.g. nucleofuge Cl or X), even for benzhydryl solvolyses; alternatively, if the more exact, two-parameter term, (sfxNf) is used, calculated effects are less accurate. A new formula (Nf=6.14 + log k(BX/any solvent/25 degrees C)), where BX refers to solvolysis of the parent benzhydryl as electrofuge, defines improved Nf values for benzhydryl substrates. The new formulae for Ef and Nf are consistent with an assumption that sf=1.00(,) and so improved correlations for benzhydryl substrates can be obtained from the additive formula: log k(RX/any solvent/25 degrees C)=(Ef + Nf). Possible extensions of this approach are also discussed.

The Complicate Observations and Multi-Parameter Land Information Constructions on Allied Telemetry Experiment (COMPLICATE)

PubMed Central

Tian, Xin; Li, Zengyuan; Chen, Erxue; Liu, Qinhuo; Yan, Guangjian; Wang, Jindi; Niu, Zheng; Zhao, Shaojie; Li, Xin; Pang, Yong; Su, Zhongbo; van der Tol, Christiaan; Liu, Qingwang; Wu, Chaoyang; Xiao, Qing; Yang, Le; Mu, Xihan; Bo, Yanchen; Qu, Yonghua; Zhou, Hongmin; Gao, Shuai; Chai, Linna; Huang, Huaguo; Fan, Wenjie; Li, Shihua; Bai, Junhua; Jiang, Lingmei; Zhou, Ji

2015-01-01

The Complicate Observations and Multi-Parameter Land Information Constructions on Allied Telemetry Experiment (COMPLICATE) comprises a network of remote sensing experiments designed to enhance the dynamic analysis and modeling of remotely sensed information for complex land surfaces. Two types of experimental campaigns were established under the framework of COMPLICATE. The first was designed for continuous and elaborate experiments. The experimental strategy helps enhance our understanding of the radiative and scattering mechanisms of soil and vegetation and modeling of remotely sensed information for complex land surfaces. To validate the methodologies and models for dynamic analyses of remote sensing for complex land surfaces, the second campaign consisted of simultaneous satellite-borne, airborne, and ground-based experiments. During field campaigns, several continuous and intensive observations were obtained. Measurements were undertaken to answer key scientific issues, as follows: 1) Determine the characteristics of spatial heterogeneity and the radiative and scattering mechanisms of remote sensing on complex land surfaces. 2) Determine the mechanisms of spatial and temporal scale extensions for remote sensing on complex land surfaces. 3) Determine synergist inversion mechanisms for soil and vegetation parameters using multi-mode remote sensing on complex land surfaces. Here, we introduce the background, the objectives, the experimental designs, the observations and measurements, and the overall advances of COMPLICATE. As a result of the implementation of COMLICATE and for the next several years, we expect to contribute to quantitative remote sensing science and Earth observation techniques. PMID:26332035

Description of Paralactobacillus selangorensis gen. nov., sp. nov., a new lactic acid bacterium isolated from chili bo, a Malaysian food ingredient.

PubMed

Leisner, J J; Vancanneyt, M; Goris, J; Christensen, H; Rusul, G

2000-01-01

Paralactobacillus selangorensis gen. nov., sp. nov. is described. This organism, isolated from a Malaysian food ingredient called chili bo, is an obligatory homofermentative, rod-shaped lactic acid bacterium. The G+C content is 46.1-46.2+/-0.3 mol%. Earlier 16S rRNA studies showed that this organism constitutes a new taxon distantly related to the Lactobacillus casei-Pediococcus group. A phenotypic description that distinguishes Paralactobacillus selangorensis from other genera of lactic acid bacteria is presented. The type strain of Paralactobacillus selangorensis is LMG 17710T.

General relativistic description of the observed galaxy power spectrum: Do we understand what we measure?

DOE Office of Scientific and Technical Information (OSTI.GOV)

Yoo, Jaiyul

2010-10-15

We extend the general relativistic description of galaxy clustering developed in Yoo, Fitzpatrick, and Zaldarriaga (2009). For the first time we provide a fully general relativistic description of the observed matter power spectrum and the observed galaxy power spectrum with the linear bias ansatz. It is significantly different from the standard Newtonian description on large scales and especially its measurements on large scales can be misinterpreted as the detection of the primordial non-Gaussianity even in the absence thereof. The key difference in the observed galaxy power spectrum arises from the real-space matter fluctuation defined as the matter fluctuation at themore » hypersurface of the observed redshift. As opposed to the standard description, the shape of the observed galaxy power spectrum evolves in redshift, providing additional cosmological information. While the systematic errors in the standard Newtonian description are negligible in the current galaxy surveys at low redshift, correct general relativistic description is essential for understanding the galaxy power spectrum measurements on large scales in future surveys with redshift depth z{>=}3. We discuss ways to improve the detection significance in the current galaxy surveys and comment on applications of our general relativistic formalism in future surveys.« less

Laser pulse shape design for laser-indirect-driven quasi-isentropic compression experiments

NASA Astrophysics Data System (ADS)

Xue, Quanxi; Jiang, Shaoen; Wang, Zhebin; Wang, Feng; Zhao, Xueqing; Ding, Yongkun

2018-02-01

Laser pulse shape design is a key work in the design of indirect-laser-driven experiments, especially for long pulse laser driven quasi-isentropic compression experiments. A method for designing such a laser pulse shape is given here. What's more, application experiments were performed, and the results of a typical shot are presented. At last of this article, the details of the application of the method are discussed, such as the equation parameter choice, radiation ablation pressure expression, and approximations in the method. The application shows that the method can provide reliable descriptions of the energy distribution in a hohlraum target; thus, it can be used in the design of long-pulse laser driven quasi-isentropic compression experiments and even other indirect-laser-driven experiments.

Critical heat flux for water boiling in channels. Modern state, typical regularities, unsolved problems, and ways for solving them (a review)

NASA Astrophysics Data System (ADS)

Bobkov, V. P.

2015-02-01

Some general matters concerned with description of burnout in channels are outlined. Data obtained from experimental investigations on critical heat fluxes (CHF) in different channels, CHF data banks, the main determining parameters, CHF basic dependences, and a system of correction functions are discussed. Two methods for estimating the CHF description errors are analyzed. The influence of operating parameters, transverse sizes of channels, and conditions at their inlet are analyzed. The effects of heat-transfer surface shape and heat supply arrangement are considered for concentric annular channels. The notions of a thermal boundary layer and an elementary thermal cell during burnout in channels with an intricate cross section are defined. New notions for describing CHF in rod assemblies are introduced: bundle effect, thermal misalignment, assembly-section-averaged and local parameters (for an elementary cell), cell-wise CHF analysis in bundles, and standard and nonstandard cells. Possible influence of wall thermophysical properties on CHF in dense assemblies and other effects are considered. Thermal interaction of nonequivalent cells and the effect of heat supply arrangement over the cell perimeter are analyzed. Special attention is paid to description of the effect the heat release nonuniformity along the channels has on CHF. Objectives to be pursued by studies of CHF in channels of different cross-section shapes are formulated.

Use of 3D techniques for virtual production

NASA Astrophysics Data System (ADS)

Grau, Oliver; Price, Marc C.; Thomas, Graham A.

2000-12-01

Virtual production for broadcast is currently mainly used in the form of virtual studios, where the resulting media is a sequence of 2D images. With the steady increase of 3D computing power in home PCs and the technical progress in 3D display technology, the content industry is looking for new kinds of program material, which makes use of 3D technology. The applications range form analysis of sport scenes, 3DTV, up to the creation of fully immersive content. In a virtual studio a camera films one or more actors in a controlled environment. The pictures of the actors can be segmented very accurately in real time using chroma keying techniques. The isolated silhouette can be integrated into a new synthetic virtual environment using a studio mixer. The resulting shape description of the actors is 2D so far. For the realization of more sophisticated optical interactions of the actors with the virtual environment, such as occlusions and shadows, an object-based 3D description of scenes is needed. However, the requirements of shape accuracy, and the kind of representation, differ in accordance with the application. This contribution gives an overview of requirements and approaches for the generation of an object-based 3D description in various applications studied by the BBC R and D department. An enhanced Virtual Studio for 3D programs is proposed that covers a range of applications for virtual production.

Autism, Asperger syndrome and brain mechanisms for the attribution of mental states to animated shapes.

PubMed

Castelli, Fulvia; Frith, Chris; Happé, Francesca; Frith, Uta

2002-08-01

Ten able adults with autism or Asperger syndrome and 10 normal volunteers were PET scanned while watching animated sequences. The animations depicted two triangles moving about on a screen in three different conditions: moving randomly, moving in a goal-directed fashion (chasing, fighting), and moving interactively with implied intentions (coaxing, tricking). The last condition frequently elicited descriptions in terms of mental states that viewers attributed to the triangles (mentalizing). The autism group gave fewer and less accurate descriptions of these latter animations, but equally accurate descriptions of the other animations compared with controls. While viewing animations that elicited mentalizing, in contrast to randomly moving shapes, the normal group showed increased activation in a previously identified mentalizing network (medial prefrontal cortex, superior temporal sulcus at the temporo-parietal junction and temporal poles). The autism group showed less activation than the normal group in all these regions. However, one additional region, extrastriate cortex, which was highly active when watching animations that elicited mentalizing, showed the same amount of increased activation in both groups. In the autism group this extrastriate region showed reduced functional connectivity with the superior temporal sulcus at the temporo-parietal junction, an area associated with the processing of biological motion as well as with mentalizing. This finding suggests a physiological cause for the mentalizing dysfunction in autism: a bottleneck in the interaction between higher order and lower order perceptual processes.

Description and recognition of faces from 3D data

NASA Astrophysics Data System (ADS)

Coombes, Anne M.; Richards, Robin; Linney, Alfred D.; Bruce, Vicki; Fright, Rick

1992-12-01

A method based on differential geometry, is presented for mathematically describing the shape of the facial surface. Three-dimensional data for the face are collected by optical surface scanning. The method allows the segmentation of the face into regions of a particular `surface type,' according to the surface curvature. Eight different surface types are produced which all have perceptually meaningful interpretations. The correspondence of the surface type regions to the facial features are easily visualized, allowing a qualitative assessment of the face. A quantitative description of the face in terms of the surface type regions can be produced and the variation of the description between faces is demonstrated. A set of optical surface scans can be registered together and averages to produce an average male and average female face. Thus an assessment of how individuals vary from the average can be made as well as a general statement about the differences between male and female faces. This method will enable an investigation to be made as to how reliably faces can be individuated by their surface shape which, if feasible, may be the basis of an automatic system for recognizing faces. It also has applications in physical anthropology, for classification of the face, facial reconstructive surgery, to quantify the changes in a face altered by reconstructive surgery and growth, and in visual perception, to assess the recognizability of faces. Examples of some of these applications are presented.

The multi-parameter borehole system and high resolution seismic studies in the western part of the main Marmara Fault in the frame of MARSITE Project.

NASA Astrophysics Data System (ADS)

Ozel, Oguz; Guralp, Cansun; Tunc, Suleyman; Yalcinkaya, Esref

2016-04-01

The main objective of this study is to install a multi-parameter borehole system and surface array as close to the main Marmara Fault (MMF) in the western Marmara Sea as possible, and measure continuously the evolution of the state of the fault zone surrounding the MMF and to detect any anomaly or change, which may occur before earthquakes by making use of the data from the arrays already running in the eastern part of the Marmara Sea. The multi-parameter borehole system is composed of very wide dynamic range and stable borehole (VBB) broad band seismic sensor, and incorporate strain meter, tilt meter, and temperature and local hydrostatic pressure measuring devices. The borehole seismic station uses the latest update technologies and design ideas to record "Earth tides" signals to the smallest magnitude -3 events. Additionally, a surface microearthquake observation array, consisting of 8-10 seismometers around the borehole is established to obtain continuous high resolution locations of micro-seismicity and to better understand the existing seismically active structures and their roles in local tectonic settings.Bringing face to face the seismograms of microearthquakes recorded by borehole and surface instruments portrays quite different contents. The shorter recording duration and nearly flat frequency spectrum up to the Nyquist frequencies of borehole records are faced with longer recording duration and rapid decay of spectral amplitudes at higher frequencies of a surface seismogram. The main causative of the observed differences are near surface geology effects that mask most of the source related information the seismograms include, and that give rise to scattering, generating longer duration seismograms. In view of these circumstances, studies on microearthquakes employing surface seismograms may bring on misleading results. Particularly, the works on earthquake physics and nucleation process of earthquakes requires elaborate analysis of tiny events. It is obvious from the studies on the nucleation process of the 1999 earthquake that tens of minutes before the major rupture initiate noteworthy microearthquake activity happened. The starting point of the 1999 rupture was a site of swarm activity noticed a few decades prior the main shock. Nowadays, analogous case is probable in western Marmara Sea region, prone to a major event in near future where the seismic activity is prevailing along the impending rupture zone. Deploying a borehole system eastern end of the Ganos fault zone may yield invaluable data to closely inspect and monitor the last stages of the preparation stage of major rupture.

Tailoring therapies—improving the management of early breast cancer: St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2015

PubMed Central

Coates, A. S.; Winer, E. P.; Goldhirsch, A.; Gelber, R. D.; Gnant, M.; Piccart-Gebhart, M.; Thürlimann, B.; Senn, H.-J.

2015-01-01

The 14th St Gallen International Breast Cancer Conference (2015) reviewed substantial new evidence on locoregional and systemic therapies for early breast cancer. Further experience has supported the adequacy of tumor margins defined as ‘no ink on invasive tumor or DCIS’ and the safety of omitting axillary dissection in specific cohorts. Radiotherapy trials support irradiation of regional nodes in node-positive disease. Considering subdivisions within luminal disease, the Panel was more concerned with indications for the use of specific therapies, rather than surrogate identification of intrinsic subtypes as measured by multiparameter molecular tests. For the treatment of HER2-positive disease in patients with node-negative cancers up to 1 cm, the Panel endorsed a simplified regimen comprising paclitaxel and trastuzumab without anthracycline as adjuvant therapy. For premenopausal patients with endocrine responsive disease, the Panel endorsed the role of ovarian function suppression with either tamoxifen or exemestane for patients at higher risk. The Panel noted the value of an LHRH agonist given during chemotherapy for premenopausal women with ER-negative disease in protecting against premature ovarian failure and preserving fertility. The Panel noted increasing evidence for the prognostic value of commonly used multiparameter molecular markers, some of which also carried prognostic information for late relapse. The Panel noted that the results of such tests, where available, were frequently used to assist decisions about the inclusion of cytotoxic chemotherapy in the treatment of patients with luminal disease, but noted that threshold values had not been established for this purpose for any of these tests. Multiparameter molecular assays are expensive and therefore unavailable in much of the world. The majority of new breast cancer cases and breast cancer deaths now occur in less developed regions of the world. In these areas, less expensive pathology tests may provide valuable information. The Panel recommendations on treatment are not intended to apply to all patients, but rather to establish norms appropriate for the majority. Again, economic considerations may require that less expensive and only marginally less effective therapies may be necessary in less resourced areas. Panel recommendations do not imply unanimous agreement among Panel members. Indeed, very few of the 200 questions received 100% agreement from the Panel. In the text below, wording is intended to convey the strength of Panel support for each recommendation, while details of Panel voting on each question are available in supplementary Appendix S2, available at Annals of Oncology online. PMID:25939896

The shape of a hole and that of the surface-with-hole cannot be analyzed separately.

PubMed

Bertamini, Marco; Helmy, Mai Salah

2012-08-01

Figure-ground organization has a central role in visual perception, since it creates the regions to which properties, such as shape descriptions, are then assigned. However, there is disagreement on how much shape analysis is independent of figure-ground. The reversal of figure-ground of a single closed region is the purest form of figure-ground organization, and the two resulting percepts are that of an object and that of a hole. Both object and hole are nonaccidental regions and can share an identical outline. We devised a test of how figure-ground and contour ownership dramatically affect how shape is processed. Observers judged the shape of a contour that could be either the same as or different from an irrelevant surrounding contour. We report that different (incongruent) inside and outside contours produce a stronger interference effect when they form a single object-with-hole, as compared with a hierarchical set of surfaces or a single hole separating different surfaces (a trench). We conclude that (1) which surface owns the contour constrains the interference between shapes and that (2) despite some recent claims, holes do not display objectlike properties.

Flying mirror model for interaction of a super-intense laser pulse with a thin plasma layer: Transparency and shaping of linearly polarized laser pulses

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kulagin, Victor V.; Cherepenin, Vladimir A.; Hur, Min Sup

2007-11-15

A self-consistent one-dimensional (1D) flying mirror model is developed for description of an interaction of an ultra-intense laser pulse with a thin plasma layer (foil). In this model, electrons of the foil can have large longitudinal displacements and relativistic longitudinal momenta. An approximate analytical solution for a transmitted field is derived. Transmittance of the foil shows not only a nonlinear dependence on the amplitude of the incident laser pulse, but also time dependence and shape dependence in the high-transparency regime. The results are compared with particle-in-cell (PIC) simulations and a good agreement is ascertained. Shaping of incident laser pulses usingmore » the flying mirror model is also considered. It can be used either for removing a prepulse or for reducing the length of a short laser pulse. The parameters of the system for effective shaping are specified. Predictions of the flying mirror model for shaping are compared with the 1D PIC simulations, showing good agreement.« less

Shape optimization of three-dimensional stamped and solid automotive components

NASA Technical Reports Server (NTRS)

Botkin, M. E.; Yang, R.-J.; Bennett, J. A.

1987-01-01

The shape optimization of realistic, 3-D automotive components is discussed. The integration of the major parts of the total process: modeling, mesh generation, finite element and sensitivity analysis, and optimization are stressed. Stamped components and solid components are treated separately. For stamped parts a highly automated capability was developed. The problem description is based upon a parameterized boundary design element concept for the definition of the geometry. Automatic triangulation and adaptive mesh refinement are used to provide an automated analysis capability which requires only boundary data and takes into account sensitivity of the solution accuracy to boundary shape. For solid components a general extension of the 2-D boundary design element concept has not been achieved. In this case, the parameterized surface shape is provided using a generic modeling concept based upon isoparametric mapping patches which also serves as the mesh generator. Emphasis is placed upon the coupling of optimization with a commercially available finite element program. To do this it is necessary to modularize the program architecture and obtain shape design sensitivities using the material derivative approach so that only boundary solution data is needed.

Axi-symmetric patterns of active polar filaments on spherical and composite surfaces

NASA Astrophysics Data System (ADS)

Srivastava, Pragya; Rao, Madan

2014-03-01

Experiments performed on Fission Yeast cells of cylindrical and spherical shapes, rod-shaped bacteria and reconstituted cylindrical liposomes suggest the influence of cell geometry on patterning of cortical actin. A theoretical model based on active hydrodynamic description of cortical actin that includes curvature-orientation coupling predicts spontaneous formation of acto-myosin rings, cables and nodes on cylindrical and spherical geometries [P. Srivastava et al, PRL 110, 168104(2013)]. Stability and dynamics of these patterns is also affected by the cellular shape and has been observed in experiments performed on Fission Yeast cells of spherical shape. Motivated by this, we study the stability and dynamics of axi-symmetric patterns of active polar filaments on the surfaces of spherical, saddle shaped and conical geometry and classify the stable steady state patterns on these surfaces. Based on the analysis of the fluorescence images of Myosin-II during ring slippage we propose a simple mechanical model for ring-sliding based on force balance and make quantitative comparison with the experiments performed on Fission Yeast cells. NSF Grant DMR-1004789 and Syracuse Soft Matter Program.

A new model for gravitational potential perturbations in disks of spiral galaxies. An application to our Galaxy

NASA Astrophysics Data System (ADS)

Junqueira, T. C.; Lépine, J. R. D.; Braga, C. A. S.; Barros, D. A.

2013-02-01

Aims: We propose a new, more realistic description of the perturbed gravitational potential of spiral galaxies, with spiral arms having Gaussian-shaped groove profiles. The aim is to reach a self-consistent description of the spiral structure, that is, one in which an initial potential perturbation generates, by means of the stellar orbits, spiral arms with a profile similar to that of the imposed perturbation. Self-consistency is a condition for having long-lived structures. Methods: Using the new perturbed potential, we investigate the stable stellar orbits in galactic disks for galaxies with no bar or with only a weak bar. The model is applied to our Galaxy by making use of the axisymmetric component of the potential computed from the Galactic rotation curve, in addition to other input parameters similar to those of our Galaxy. The influence of the bulge mass on the stellar orbits in the inner regions of a disk is also investigated. Results: The new description offers the advantage of easy control of the parameters of the Gaussian profile of its potential. We compute the density contrast between arm and inter-arm regions. We find a range of values for the perturbation amplitude from 400 to 800 km2 s-2 kpc-1, which implies an approximate maximum ratio of the tangential force to the axisymmetric force between 3% and 6%. Good self-consistency of arm shapes is obtained between the Inner Lindblad resonance (ILR) and the 4:1 resonance. Near the 4:1 resonance the response density starts to deviate from the imposed logarithmic spiral form. This creates bifurcations that appear as short arms. Therefore the deviation from a perfect logarithmic spiral in galaxies can be understood as a natural effect of the 4:1 resonance. Beyond the 4:1 resonance we find closed orbits that have similarities with the arms observed in our Galaxy. In regions near the center, elongated stellar orbits appear naturally, in the presence of a massive bulge, without imposing any bar-shaped potential, but only extending the spiral perturbation a little inward of the ILR. This suggests that a bar is formed with a half-size ~3 kpc by a mechanism similar to that of the spiral arms. Conclusions: The potential energy perturbation that we adopted represents an important step in the direction of self-consistency, compared to previous sine function descriptions of the potential. In addition, our model produces a realistic description of the spiral structure, which is able to explain several details that were not yet understood.

Three-dimensional description and mathematical characterization of the parasellar internal carotid artery in human infants

PubMed Central

Meng, Stefan; da F Costa, Luciano; Geyer, Stefan H; Viana, Matheus P; Reiter, Christian; Müller, Gerd B; Weninger, Wolfgang J

2008-01-01

Inside the ‘cavernous sinus’ or ‘parasellar region’ the human internal carotid artery takes the shape of a siphon that is twisted and torqued in three dimensions and surrounded by a network of veins. The parasellar section of the internal carotid artery is of broad biological and medical interest, as its peculiar shape is associated with temperature regulation in the brain and correlated with the occurrence of vascular pathologies. The present study aims to provide anatomical descriptions and objective mathematical characterizations of the shape of the parasellar section of the internal carotid artery in human infants and its modifications during ontogeny. Three-dimensional (3D) computer models of the parasellar section of the internal carotid artery of infants were generated with a state-of-the-art 3D reconstruction method and analysed using both traditional morphometric methods and novel mathematical algorithms. We show that four constant, demarcated bends can be described along the infant parasellar section of the internal carotid artery, and we provide measurements of their angles. We further provide calculations of the curvature and torsion energy, and the total complexity of the 3D skeleton of the parasellar section of the internal carotid artery, and compare the complexity of this in infants and adults. Finally, we examine the relationship between shape parameters of the parasellar section of the internal carotid artery in infants, and the occurrence of intima cushions, and evaluate the reliability of subjective angle measurements for characterizing the complexity of the parasellar section of the internal carotid artery in infants. The results can serve as objective reference data for comparative studies and for medical imaging diagnostics. They also form the basis for a new hypothesis that explains the mechanisms responsible for the ontogenetic transformation in the shape of the parasellar section of the internal carotid artery. PMID:18397239

Borehole dilatometer installation, operation, and maintenance at sites in Hawaii

USGS Publications Warehouse

Myren, G.D.; Johnston, M.J.S.; Mueller, R.J.

2006-01-01

In response to concerns about the potential hazard of Mauna Loa volcano in Hawaii, the USGS began efforts in 1998 to add four high-resolution borehole sites. Located at these sites are; strainmeters, tiltmeters, seismometers, accelerometers and other instrumentation. These instruments are capable of providing continuous monitoring of the magma movement under Mauna Loa. Each site was planned to provide multi-parameter monitoring of volcanic activity. In June of 2000, a contract was let for the core drilling of three of these four sites. They are located at Hokukano (west side of Mauna Loa) above Captain Cook, Hawaii; at Mauna Loa Observatory (11,737 feet near the summit), and at Mauna Loa Strip Road (east side of Mauna Loa). Another site was chosen near Halema'uma u' and Kilauea's summit, in the Keller deep well. (See maps). The locations of these instruments are shown in Figure 1 with their latitude and longitude in Table 1. The purpose of this network is to monitor crustal deformation associated with volcanic intrusions and earthquakes on Mauna Loa and Kilauea volcanoes. This report describes the methods used to locate sites, install dilatometers, other instrumentation, and telemetry. We also provide a detailed description of the electronics used for signal amplification and telemetry, plus techniques used for instrument maintenance. Instrument sites were selected in regions of hard volcanic rock where the expected signals from magmatic activity were calculated to be a maximum and the probability of earthquakes with magnitude 4 or greater is large. At each location, an attempt was made to separate tectonic and volcanic signals from known noise sources for each instrument type.

Assessment of beating parameters in human induced pluripotent stem cells enables quantitative in vitro screening for cardiotoxicity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sirenko, Oksana, E-mail: oksana.sirenko@moldev.com; Cromwell, Evan F., E-mail: evan.cromwell@moldev.com; Crittenden, Carole

2013-12-15

Human induced pluripotent stem cell (iPSC)-derived cardiomyocytes show promise for screening during early drug development. Here, we tested a hypothesis that in vitro assessment of multiple cardiomyocyte physiological parameters enables predictive and mechanistically-interpretable evaluation of cardiotoxicity in a high-throughput format. Human iPSC-derived cardiomyocytes were exposed for 30 min or 24 h to 131 drugs, positive (107) and negative (24) for in vivo cardiotoxicity, in up to 6 concentrations (3 nM to 30 uM) in 384-well plates. Fast kinetic imaging was used to monitor changes in cardiomyocyte function using intracellular Ca{sup 2+} flux readouts synchronous with beating, and cell viability. Amore » number of physiological parameters of cardiomyocyte beating, such as beat rate, peak shape (amplitude, width, raise, decay, etc.) and regularity were collected using automated data analysis. Concentration–response profiles were evaluated using logistic modeling to derive a benchmark concentration (BMC) point-of-departure value, based on one standard deviation departure from the estimated baseline in vehicle (0.3% dimethyl sulfoxide)-treated cells. BMC values were used for cardiotoxicity classification and ranking of compounds. Beat rate and several peak shape parameters were found to be good predictors, while cell viability had poor classification accuracy. In addition, we applied the Toxicological Prioritization Index (ToxPi) approach to integrate and display data across many collected parameters, to derive “cardiosafety” ranking of tested compounds. Multi-parameter screening of beating profiles allows for cardiotoxicity risk assessment and identification of specific patterns defining mechanism-specific effects. These data and analysis methods may be used widely for compound screening and early safety evaluation in drug development. - Highlights: • Induced pluripotent stem cell-derived cardiomyocytes are promising in vitro models. • We tested if evaluation of cardiotoxicity is possible in a high-throughput format. • The assay shows benefits of automated data integration across multiple parameters. • Quantitative assessment of concentration–response is possible using iPSCs. • Multi-parametric screening allows for cardiotoxicity risk assessment.« less

Models of Reality: Shaping Thought and Action.

ERIC Educational Resources Information Center

Richardson, Jacques, Ed.

The 21 essays in this two-part book provide conceptual and operational understanding of the nature of models as representations of reality and as tools for description, analysis, interpretation, and forecasting. Topic areas addressed in part 1 (concept) include: the nature of models; the earth as a system; the determination of form; some…

Edge-Assignment and Figure-Ground Segmentation in Short-Term Visual Matching.

ERIC Educational Resources Information Center

Driver, Jon; Baylis, Gordon

1996-01-01

Eight experiments involving 99 college students examined the role of edge-assignment in a contour matching task. Edge-matching performance was not based solely on a raw description of the edges themselves. Results suggest a pervasive tendency within the visual system to go beyond the edges toward figural shapes. (SLD)

National Migrant Education Program Math Skills Information System.

ERIC Educational Resources Information Center

de la Rosa, Raul; Hackett, Eugene deG.

The educational background and issues which shaped the design of the National Migrant Education Program Math Skills Information System are explained in this report, along with a full description of the features of the system and its operation. It discusses the variety of math skills information used to permit teachers to input and receive math…

"Scissors, Paper, Stone": Perceptual Foundations of Noun Classifier Systems.

ERIC Educational Resources Information Center

Erbaugh, Mary S.

While all languages use shape to classify unfamiliar objects, some languages as diverse as Mandarin, Thai, Japanese, Mohawk, and American Sign Language lexicalize these and other types of description as noun classifiers. Classification does not develop from a fixed set of features in the object, but is discourse-sensitive and invoked when it would…

Modeling biological disturbances in LANDIS: a module description and demonstration using spruce budworm

Treesearch

Brian R. Sturtevant; Eric J. Gustafson; Wei Li; Hong S. He

2004-01-01

Insects and diseases are common disturbance agents in forested ecosystems. Severe outbreaks can cause significant changes in tree species composition, age structure, and fuel conditions over broad areas. To investigate the role of biological disturbances in shaping forest landscapes over time, we constructed a new "biological disturbance agent" (BDA) module...

A Model for Teaching Ethical Meta-Principles: A Descriptive Experience

ERIC Educational Resources Information Center

Jones, Irma S.; Rivas, Olivia; Mancillas, Margarita

2009-01-01

As students, educators, outreach and community service experts enter their distinct professional worlds, each will be compelled to make a wide variety of decisions. The shaping of peoples' ethical beliefs occurs through personal experiences as well as family, culture, religion and peer pressure. In order for these students, educators, outreach and…

Sources, Developments and Directions of Task-Based Language Teaching

ERIC Educational Resources Information Center

Bygate, Martin

2016-01-01

This paper provides an outline of the origins, the current shape and the potential directions of task-based language teaching (TBLT) as an approach to language pedagogy. It first offers a brief description of TBLT and considers its origins within language teaching methodology and second language acquisition. It then summarises the current position…

Articulating Breath: Writing Charcot's Hysteric with "Performance Writing"

ERIC Educational Resources Information Center

Worden, Jessica

2014-01-01

The overlap between the visual and textual in practice research provides an opportunity to explore ways of presenting knowledge through "performance writin". The purpose of this paper is to demonstrate how a performance writing practice can be incorporated into and shape research writing. This text uses descriptions of Jean-Martin…

Literacy and Complexity: On Using Technology within Emergent Learning Structures with Young Learners

ERIC Educational Resources Information Center

Laidlaw, Linda; Wong, Suzanna So-Har

2016-01-01

This article presents and describes how we have used notions and structures informed by complexity thinking to shape new descriptions and approaches to understanding "new literacy" practices with young learners. Using data from two studies: a two year project working with kindergarten children using drama and digital tools to develop…

Nation State versus National Identity: State and Inspectorate in Mid-Victorian Wales.

ERIC Educational Resources Information Center

Williams, H. G.

2000-01-01

Examines the relationship between state and inspectorate in Wales by tracing the history of Harry Longueville Jones, the first Her Majesty's Inspectorate (HMI) of Church schools. Considers how he tried to shape an educational system suitable for the needs of Welsh communities. Includes a historical description of Wales. (CMK)

Why Economists Are Part of the Problem

ERIC Educational Resources Information Center

Marglin, Stephen A.

2009-01-01

Economics is a two-faced discipline. It claims to be a science, describing the world without preconception or value judgment. The reality is that descriptive economics has been shaped by a framework of assumptions geared more to its normative message than to its pretensions. The self-interested individual--who rationally calculates how to achieve…

Structuring Opportunity: The Role of School Context in Shaping High School Students' Occupational Aspirations

ERIC Educational Resources Information Center

Rowan-Kenyon, Heather T.; Perna, Laura W.; Swan, Amy K.

2011-01-01

This study explores the occupational aspirations of high school students planning to attend college by drawing on a multilayered model of college enrollment, social cognitive career theory, and multiple descriptive case studies of 15 high schools. Students' occupational aspirations and their understanding of the education required to achieve these…

Educational Policy Research in New Zealand: Issues and Challenges.

ERIC Educational Resources Information Center

Wagemaker, H.

As exemplified by New Zealand, the nature of educational policy research is shaped by political and social factors that impinge upon the research environment. Following a description of the educational system and research funding methods, this paper analyzes three areas that affect policy research in New Zealand and addresses relevant social…

Advancements in noncontact, multiparameter physiological measurements using a webcam.

PubMed

Poh, Ming-Zher; McDuff, Daniel J; Picard, Rosalind W

2011-01-01

We present a simple, low-cost method for measuring multiple physiological parameters using a basic webcam. By applying independent component analysis on the color channels in video recordings, we extracted the blood volume pulse from the facial regions. Heart rate (HR), respiratory rate, and HR variability (HRV, an index for cardiac autonomic activity) were subsequently quantified and compared to corresponding measurements using Food and Drug Administration-approved sensors. High degrees of agreement were achieved between the measurements across all physiological parameters. This technology has significant potential for advancing personal health care and telemedicine.

Classification of Aerosol Retrievals from Spaceborne Polarimetry Using a Multiparameter Algorithm

NASA Technical Reports Server (NTRS)

Russell, Philip B.; Kacenelenbogen, Meloe; Livingston, John M.; Hasekamp, Otto P.; Burton, Sharon P.; Schuster, Gregory L.; Johnson, Matthew S.; Knobelspiesse, Kirk D.; Redemann, Jens; Ramachandran, S.;

Rational engineering correlations of diffusional and inertial particle deposition behavior in non-isothermal forced convection environments

NASA Technical Reports Server (NTRS)

Rosner, D. E.; Gokoglu, S. A.; Israel, R.

1982-01-01

A multiparameter correlation approach to the study of particle deposition rates in engineering applications is discussed with reference to two specific examples, one dealing with thermophoretically augmented small particle convective diffusion and the other involving larger particle inertial impaction. The validity of the correlations proposed here is demonstrated through rigorous computations including all relevant phenomena and interactions. Such representations are shown to minimize apparent differences between various geometric, flow, and physicochemical parameters, allowing many apparently different physicochemical situations to be described in a unified way.

Global structure of forked DNA in solution revealed by high-resolution single-molecule FRET.

PubMed

Sabir, Tara; Schröder, Gunnar F; Toulmin, Anita; McGlynn, Peter; Magennis, Steven W

2011-02-09

Branched DNA structures play critical roles in DNA replication, repair, and recombination in addition to being key building blocks for DNA nanotechnology. Here we combine single-molecule multiparameter fluorescence detection and molecular dynamics simulations to give a general approach to global structure determination of branched DNA in solution. We reveal an open, planar structure of a forked DNA molecule with three duplex arms and demonstrate an ion-induced conformational change. This structure will serve as a benchmark for DNA-protein interaction studies.

The Spaceborne Imaging Radar program: SIR-C - The next step toward EOS

NASA Technical Reports Server (NTRS)

Evans, Diane; Elachi, Charles; Cimino, Jobea

1987-01-01

The NASA Shuttle Imaging Radar SIR-C experiments will investigate earth surface and environment phenomena to deepen understanding of terra firma, biosphere, hydrosphere, cryosphere, and atmosphere components of the earth system, capitalizing on the observational capabilities of orbiting multiparameter radar sensors alone or in combination with other sensors. The SIR-C sensor encompasses an antenna array, an exciter, receivers, a data-handling network, and the ground SAR processor. It will be possible to steer the antenna beam electronically, so that the radar look angle can be varied.

Multi-objective Optimization Design of Gear Reducer Based on Adaptive Genetic Algorithms

NASA Astrophysics Data System (ADS)

Li, Rui; Chang, Tian; Wang, Jianwei; Wei, Xiaopeng; Wang, Jinming

2008-11-01

An adaptive Genetic Algorithm (GA) is introduced to solve the multi-objective optimized design of the reducer. Firstly, according to the structure, strength, etc. in a reducer, a multi-objective optimized model of the helical gear reducer is established. And then an adaptive GA based on a fuzzy controller is introduced, aiming at the characteristics of multi-objective, multi-parameter, multi-constraint conditions. Finally, a numerical example is illustrated to show the advantages of this approach and the effectiveness of an adaptive genetic algorithm used in optimized design of a reducer.

A predictive model of asymmetric morphogenesis from 3D reconstructions of mouse heart looping dynamics

PubMed Central

Le Garrec, Jean-François; Ivanovitch, Kenzo D; Raphaël, Etienne; Bangham, J Andrew; Torres, Miguel; Coen, Enrico; Mohun, Timothy J

2017-01-01

How left-right patterning drives asymmetric morphogenesis is unclear. Here, we have quantified shape changes during mouse heart looping, from 3D reconstructions by HREM. In combination with cell labelling and computer simulations, we propose a novel model of heart looping. Buckling, when the cardiac tube grows between fixed poles, is modulated by the progressive breakdown of the dorsal mesocardium. We have identified sequential left-right asymmetries at the poles, which bias the buckling in opposite directions, thus leading to a helical shape. Our predictive model is useful to explore the parameter space generating shape variations. The role of the dorsal mesocardium was validated in Shh-/- mutants, which recapitulate heart shape changes expected from a persistent dorsal mesocardium. Our computer and quantitative tools provide novel insight into the mechanism of heart looping and the contribution of different factors, beyond the simple description of looping direction. This is relevant to congenital heart defects. PMID:29179813

Quantitative ESD Guidelines for Charged Spacecraft Derived from the Physics of Discharges

NASA Technical Reports Server (NTRS)

Frederickson, A. R.

1992-01-01

Quantitative guidelines are proposed for Electrostatic Discharge (ESD) pulse shape on charged spacecraft. The guidelines are based on existing ground test data, and on a physical description of the pulsed discharge process. The guidelines are designed to predict pulse shape for surface charging and internal charging on a wide variety of spacecraft structures. The pulses depend on the area of the sample, its capacitance to ground, and the strength of the electric field in the vacuum adjacent to the charged surface. By knowing the pulse shape, current vs. time, one can determine if nearby circuits are threatened by the pulse. The quantitative guidelines might be used to estimate the level of threat to an existing spacecraft, or to redesign a spacecraft to reduce its pulses to a known safe level. The experiments which provide the data and the physics that allow one to interpret the data will be discussed, culminating in examples of how to predict pulse shape/size. This method has been used, but not confirmed, on several spacecraft.

Three dimensional shape measurement of wear particle by iterative volume intersection

NASA Astrophysics Data System (ADS)

Wu, Hongkun; Li, Ruowei; Liu, Shilong; Rahman, Md Arifur; Liu, Sanchi; Kwok, Ngaiming; Peng, Zhongxiao

2018-04-01

The morphology of wear particle is a fundamental indicator where wear oriented machine health can be assessed. Previous research proved that thorough measurement of the particle shape allows more reliable explanation of the occurred wear mechanism. However, most of current particle measurement techniques are focused on extraction of the two-dimensional (2-D) morphology, while other critical particle features including volume and thickness are not available. As a result, a three-dimensional (3-D) shape measurement method is developed to enable a more comprehensive particle feature description. The developed method is implemented in three steps: (1) particle profiles in multiple views are captured via a camera mounted above a micro fluid channel; (2) a preliminary reconstruction is accomplished by the shape-from-silhouette approach with the collected particle contours; (3) an iterative re-projection process follows to obtain the final 3-D measurement by minimizing the difference between the original and the re-projected contours. Results from real data are presented, demonstrating the feasibility of the proposed method.

A new method of automatic landmark tagging for shape model construction via local curvature scale

NASA Astrophysics Data System (ADS)

Rueda, Sylvia; Udupa, Jayaram K.; Bai, Li

2008-03-01

Segmentation of organs in medical images is a difficult task requiring very often the use of model-based approaches. To build the model, we need an annotated training set of shape examples with correspondences indicated among shapes. Manual positioning of landmarks is a tedious, time-consuming, and error prone task, and almost impossible in the 3D space. To overcome some of these drawbacks, we devised an automatic method based on the notion of c-scale, a new local scale concept. For each boundary element b, the arc length of the largest homogeneous curvature region connected to b is estimated as well as the orientation of the tangent at b. With this shape description method, we can automatically locate mathematical landmarks selected at different levels of detail. The method avoids the use of landmarks for the generation of the mean shape. The selection of landmarks on the mean shape is done automatically using the c-scale method. Then, these landmarks are propagated to each shape in the training set, defining this way the correspondences among the shapes. Altogether 12 strategies are described along these lines. The methods are evaluated on 40 MRI foot data sets, the object of interest being the talus bone. The results show that, for the same number of landmarks, the proposed methods are more compact than manual and equally spaced annotations. The approach is applicable to spaces of any dimensionality, although we have focused in this paper on 2D shapes.

Effective description of domain wall strings

NASA Astrophysics Data System (ADS)

Rodrigues, Davi R.; Abanov, Ar.; Sinova, J.; Everschor-Sitte, K.

2018-04-01

The analysis of domain wall dynamics is often simplified to one-dimensional physics. For domain walls in thin films, more realistic approaches require the description as two-dimensional objects. This includes the study of vortices and curvatures along the domain walls as well as the influence of boundary effects. Here we provide a theory in terms of soft modes that allows us to analytically study the physics of extended domain walls and their stability. By considering irregularly shaped skyrmions as closed domain walls, we analyze their plasticity and compare their dynamics with those of circular skyrmions. Our theory directly provides an analytical description of the excitation modes of magnetic skyrmions, previously accessible only through sophisticated micromagnetic numerical calculations and spectral analysis. These analytical expressions provide the scaling behavior of the different physics on parameters that experiments can test.

Affective Beliefs Influence the Experience of Eating Meat

PubMed Central

Anderson, Eric C.; Barrett, Lisa Feldman

2016-01-01

People believe they experience the world objectively, but research continually demonstrates that beliefs influence perception. Emerging research indicates that beliefs influence the experience of eating. In three studies, we test whether beliefs about how animals are raised can influence the experience of eating meat. Samples of meat were paired with descriptions of animals raised on factory farms or raised on humane farms. Importantly, the meat samples in both conditions were identical. However, participants experienced the samples differently: meat paired with factory farm descriptions looked, smelled, and tasted less pleasant. Even basic properties of flavor were influenced: factory farmed samples tasted more salty and greasy. Finally, actual behavior was influenced: participants consumed less when samples were paired with factory farm descriptions. These findings demonstrate that the experience of eating is not determined solely by physical properties of stimuli—beliefs also shape experience. PMID:27556643

Dispatch from the field: ecology of ground-web-building spiders with description of a new species (Araneae, Symphytognathidae)

PubMed Central

2014-01-01

Abstract Crassignatha danaugirangensis sp. n. (Araneae: Symphytognathidae) was discovered during a tropical ecology field course held at the Danau Girang Field Centre in Sabah, Malaysia. A taxonomic description and accompanying ecological study were completed as course activities. To assess the ecology of this species, which belongs to the ground-web-building spider community, three habitat types were surveyed: riparian forest, recently inundated riverine forest, and oil palm plantation. Crassignatha danaugirangensis sp. n. is the most abundant ground-web-building spider species in riparian forest; it is rare or absent from the recently inundated forest and was not found in a nearby oil palm plantation. The availability of this taxonomic description may help facilitate the accumulation of data about this species and the role of inundated riverine forest in shaping invertebrate communities. PMID:24891829

Early differential sensitivity of evoked-potentials to local and global shape during the perception of three-dimensional objects.

PubMed

Leek, E Charles; Roberts, Mark; Oliver, Zoe J; Cristino, Filipe; Pegna, Alan J

2016-08-01

Here we investigated the time course underlying differential processing of local and global shape information during the perception of complex three-dimensional (3D) objects. Observers made shape matching judgments about pairs of sequentially presented multi-part novel objects. Event-related potentials (ERPs) were used to measure perceptual sensitivity to 3D shape differences in terms of local part structure and global shape configuration - based on predictions derived from hierarchical structural description models of object recognition. There were three types of different object trials in which stimulus pairs (1) shared local parts but differed in global shape configuration; (2) contained different local parts but shared global configuration or (3) shared neither local parts nor global configuration. Analyses of the ERP data showed differential amplitude modulation as a function of shape similarity as early as the N1 component between 146-215ms post-stimulus onset. These negative amplitude deflections were more similar between objects sharing global shape configuration than local part structure. Differentiation among all stimulus types was reflected in N2 amplitude modulations between 276-330ms. sLORETA inverse solutions showed stronger involvement of left occipitotemporal areas during the N1 for object discrimination weighted towards local part structure. The results suggest that the perception of 3D object shape involves parallel processing of information at local and global scales. This processing is characterised by relatively slow derivation of 'fine-grained' local shape structure, and fast derivation of 'coarse-grained' global shape configuration. We propose that the rapid early derivation of global shape attributes underlies the observed patterns of N1 amplitude modulations. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

3D model retrieval method based on mesh segmentation

NASA Astrophysics Data System (ADS)

Gan, Yuanchao; Tang, Yan; Zhang, Qingchen

2012-04-01

In the process of feature description and extraction, current 3D model retrieval algorithms focus on the global features of 3D models but ignore the combination of global and local features of the model. For this reason, they show less effective performance to the models with similar global shape and different local shape. This paper proposes a novel algorithm for 3D model retrieval based on mesh segmentation. The key idea is to exact the structure feature and the local shape feature of 3D models, and then to compares the similarities of the two characteristics and the total similarity between the models. A system that realizes this approach was built and tested on a database of 200 objects and achieves expected results. The results show that the proposed algorithm improves the precision and the recall rate effectively.

Molecular moment similarity between several nucleoside analogs of thymidine and thymidine. sil@watson.ibm.com.

PubMed

Silverman, B D; Pitman, M C; Platt, D E

1999-06-01

Molecular moment descriptors of the shape and charge distributions of twenty five nucleoside structures have been examined. The structures include thymidine as well as the difluorotoluene nucleoside analog which has been found to pair efficiently with adenine by polymerase catalysis. The remaining twenty three structures have been chosen to be as structurally similar to thymidine and to the difluorotoluene nucleoside analog as possible. The moment descriptors which include a description of the relationship of molecular charge to shape show the difluorotoluene nucleoside to be one of the most proximate molecules to thymidine in the space of the molecular moments. The calculations, therefore, suggest that polymerase specificity might be not only a consequence of molecular steric features alone but also of the molecular electrostatic environment and its registration with molecular shape.

Optimal design of damping layers in SMA/GFRP laminated hybrid composites

NASA Astrophysics Data System (ADS)

Haghdoust, P.; Cinquemani, S.; Lo Conte, A.; Lecis, N.

2017-10-01

This work describes the optimization of the shape profiles for shape memory alloys (SMA) sheets in hybrid layered composite structures, i.e. slender beams or thinner plates, designed for the passive attenuation of flexural vibrations. The paper starts with the description of the material and architecture of the investigated hybrid layered composite. An analytical method, for evaluating the energy dissipation inside a vibrating cantilever beam is developed. The analytical solution is then followed by a shape profile optimization of the inserts, using a genetic algorithm to minimize the SMA material layer usage, while maintaining target level of structural damping. Delamination problem at SMA/glass fiber reinforced polymer interface is discussed. At the end, the proposed methodology has been applied to study the hybridization of a wind turbine layered structure blade with SMA material, in order to increase its passive damping.

Potential for protein surface shape analysis using spherical harmonics and 3D Zernike descriptors.

PubMed

Venkatraman, Vishwesh; Sael, Lee; Kihara, Daisuke

2009-01-01

With structure databases expanding at a rapid rate, the task at hand is to provide reliable clues to their molecular function and to be able to do so on a large scale. This, however, requires suitable encodings of the molecular structure which are amenable to fast screening. To this end, moment-based representations provide a compact and nonredundant description of molecular shape and other associated properties. In this article, we present an overview of some commonly used representations with specific focus on two schemes namely spherical harmonics and their extension, the 3D Zernike descriptors. Key features and differences of the two are reviewed and selected applications are highlighted. We further discuss recent advances covering aspects of shape and property-based comparison at both global and local levels and demonstrate their applicability through some of our studies.

Molecular quantum control landscapes in von Neumann time-frequency phase space

NASA Astrophysics Data System (ADS)

Ruetzel, Stefan; Stolzenberger, Christoph; Fechner, Susanne; Dimler, Frank; Brixner, Tobias; Tannor, David J.

2010-10-01

Recently we introduced the von Neumann representation as a joint time-frequency description for femtosecond laser pulses and suggested its use as a basis for pulse shaping experiments. Here we use the von Neumann basis to represent multidimensional molecular control landscapes, providing insight into the molecular dynamics. We present three kinds of time-frequency phase space scanning procedures based on the von Neumann formalism: variation of intensity, time-frequency phase space position, and/or the relative phase of single subpulses. The shaped pulses produced are characterized via Fourier-transform spectral interferometry. Quantum control is demonstrated on the laser dye IR140 elucidating a time-frequency pump-dump mechanism.

Molecular quantum control landscapes in von Neumann time-frequency phase space.

PubMed

Ruetzel, Stefan; Stolzenberger, Christoph; Fechner, Susanne; Dimler, Frank; Brixner, Tobias; Tannor, David J

2010-10-28

Recently we introduced the von Neumann representation as a joint time-frequency description for femtosecond laser pulses and suggested its use as a basis for pulse shaping experiments. Here we use the von Neumann basis to represent multidimensional molecular control landscapes, providing insight into the molecular dynamics. We present three kinds of time-frequency phase space scanning procedures based on the von Neumann formalism: variation of intensity, time-frequency phase space position, and/or the relative phase of single subpulses. The shaped pulses produced are characterized via Fourier-transform spectral interferometry. Quantum control is demonstrated on the laser dye IR140 elucidating a time-frequency pump-dump mechanism.

Dichroism, chirality, and polarization eigenstates in Babinet nanoslot-dimer membrane metamaterials

NASA Astrophysics Data System (ADS)

Zhukovsky, Sergei V.; Chigrin, Dmitry N.; Kremers, Christian; Lavrinenko, Andrei V.

2013-11-01

We present a detailed theoretical description of the optical properties of planar metamaterials comprising a metal membrane patterned with openings (microslots) arranged in closely located couples (dimers). Using the covariant coupled-dipole approach, the effective material tensors of such a metamaterial are recovered, and contributions responsible for elliptical dichroism and optical activity are identified. Polarization conversion properties of II-shaped and V-shaped dimers are determined and explained in terms of elliptically polarized eigenmodes of the metamaterial. Good agreement with direct numerical simulations is demonstrated. The results obtained are promising for the design of thin-film frequency selective polarization shapers for terahertz waves.

Biochemical changes related to hypoxia during cerebral aneurysm surgery: combined microdialysis and tissue oxygen monitoring: case report.

PubMed

Hutchinson, P J; Al-Rawi, P G; O'Connell, M T; Gupta, A K; Pickard, J D; Kirkpatrick, P J

2000-01-01

The objective of this study was to monitor brain metabolism on-line during aneurysm surgery, by combining the use of a multiparameter (brain tissue oxygen, brain carbon dioxide, pH, and temperature) sensor with microdialysis (extracellular glucose, lactate, pyruvate, and glutamate). The case illustrates the potential value of these techniques by demonstrating the effects of adverse physiological events on brain metabolism and the ability to assist in both intraoperative and postoperative decision-making. A 41-year-old woman presented with a World Federation of Neurological Surgeons Grade I subarachnoid hemorrhage. Angiography revealed a basilar artery aneurysm that was not amenable to coiling, so the aneurysm was clipped. Before the craniotomy was performed, a multiparameter sensor and a microdialysis catheter were inserted to monitor brain metabolism. During the operation, the brain oxygen level decreased, in relation to biochemical changes, including the reduction of extracellular glucose and pyruvate and the elevation of lactate and glutamate. These changes were reversible. However, when the craniotomy was closed, a second decrease in brain oxygen occurred in association with brain swelling, which immediately prompted a postoperative computed tomographic scan. The scan demonstrated acute hydrocephalus, requiring external ventricular drainage. The patient made a full recovery. The monitoring techniques influenced clinical decision-making in the treatment of this patient. On-line measurement of brain tissue gases and extracellular chemistry has the potential to assist in the perioperative and postoperative management of patients undergoing complex cerebrovascular surgery and to establish the effects of intervention on brain homeostasis.

Multiparameter cell affinity chromatography: separation and analysis in a single microfluidic channel.

PubMed

Li, Peng; Gao, Yan; Pappas, Dimitri

2012-10-02

The ability to sort and capture more than one cell type from a complex sample will enable a wide variety of studies of cell proliferation and death and the analysis of disease states. In this work, we integrated a pneumatic actuated control layer to an affinity separation layer to create different antibody-coating regions on the same fluidic channel. The comparison of different antibody capture capabilities to the same cell line was demonstrated by flowing Ramos cells through anti-CD19- and anti-CD71-coated regions in the same channel. It was determined that the cell capture density on the anti-CD19 region was 2.44 ± 0.13 times higher than that on the anti-CD71-coated region. This approach can be used to test different affinity molecules for selectivity and capture efficiency using a single cell line in one separation. Selective capture of Ramos and HuT 78 cells from a mixture was also demonstrated using two antibody regions in the same channel. Greater than 90% purity was obtained on both capture areas in both continuous flow and stop flow separation modes. A four-region antibody-coated device was then fabricated to study the simultaneous, serial capture of three different cell lines. In this case the device showed effective capture of cells in a single separation channel, opening up the possibility of multiple cell sorting. Multiparameter sequential blood sample analysis was also demonstrated with high capture specificity (>97% for both CD19+ and CD4+ leukocytes). The chip can also be used to selectively treat cells after affinity separation.

Minimal residual disease assessed by multi-parameter flow cytometry is highly prognostic in adult patients with acute lymphoblastic leukaemia

PubMed Central

Ravandi, Farhad; Jorgensen, Jeffrey L.; O'Brien, Susan M.; Jabbour, Elias; Thomas, Deborah A.; Borthakur, Gautam; Garris, Rebecca; Huang, Xuelin; Garcia-Manero, Guillermo; Burger, Jan A.; Ferrajoli, Alessandra; Wierda, William; Kadia, Tapan; Jain, Nitin; Wang, Sa A.; Konoplev, Sergei; Kebriaei, Partow; Champlin, Richard E.; McCue, Deborah; Estrov, Zeev; Cortes, Jorge E; Kantarjian, Hagop M.

2016-01-01

SUMMARY The prognostic value of minimal residual disease (MRD) assessed by multi-parameter flow cytometry (MFC) was investigated among 340 adult patients with B-cell acute lymphoblastic leukaemia (B-ALL) treated between 2004 and 2014 using regimens including the hyperCVAD (hyperfractionated cyclophosphamide, vincristine, doxorubicin, dexamethasone, methotrexate, cytarabine) backbone. Among them, 323 (95%) achieved complete remission (CR) and were included in this study. Median age was 52 years (range, 15-84). Median white blood cell count (WBC) was 9.35 × 109/l (range, 0.4-658.1 ×109/l). MRD by MFC was initially assessed with a sensitivity of 0.01%, using a 15-marker, 4-colour panel and subsequently a 6-colour panel on bone marrow specimens obtained at CR achievement and at approximately 3 month intervals thereafter. MRD negative status at CR was associated with improved disease-free survival (DFS) and overall survival (OS)(P=0.004 and P=0.04, respectively). Similarly, achieving MRD negative status at approximately 3 and 6 months was associated with improved DFS (P=0.002 and P<0.0001, respectively) and OS (P=0.003 and P<0.0001, respectively). Multivariate analysis including age, WBC at presentation, cytogenetics (standard vs. high risk) and MRD status at CR, 3 months and 6 months, indicated that MRD negative status at CR was an independent predictor of DFS (P<0.05). Achievement of an MRD negative state assessed by MFC is an important predictor of DFS and OS in adult patients with ALL PMID:26492205

TCSPC based approaches for multiparameter detection in living cells

NASA Astrophysics Data System (ADS)

Jahn, Karolina; Buschmann, Volker; Koberling, Felix; Hille, Carsten

2014-03-01

In living cells a manifold of processes take place simultaneously. This implies a precise regulation of intracellular ion homeostasis. In order to understand their spatio-temporal pattern comprehensively, the development of multiplexing concepts is essential. Due to the multidimensional characteristics of fluorescence dyes (absorption and emission spectra, decay time, anisotropy), the highly sensitive and non-invasive fluorescence microscopy is a versatile tool for realising multiplexing concepts. A prerequisite are analyte-specific fluorescence dyes with low cross-sensitivity to other dyes and analytes, respectively. Here, two approaches for multiparameter detection in living cells are presented. Insect salivary glands are well characterised secretory active tissues which were used as model systems to evaluate multiplexing concepts. Salivary glands secrete a KCl-rich or NaCl-rich fluid upon stimulation which is mainly regulated by intracellular Ca2+ as second messenger. Thus, pairwise detection of intracellular Na+, Cl- and Ca2+ with the fluorescent dyes ANG2, MQAE and ACR were tested. Therefore, the dyes were excited simultaneously (2-photon excitation) and their corresponding fluorescence decay times were recorded within two spectral ranges using time-correlated singlephoton counting (TCSPC). A second approach presented here is based on a new TCSPC-platform covering decay time detection from picoseconds to milliseconds. Thereby, nanosecond decaying cellular fluorescence and microsecond decaying phosphorescence of Ruthenium-complexes, which is quenched by oxygen, were recorded simultaneously. In both cases changes in luminescence decay times can be linked to changes in analyte concentrations. In consequence of simultaneous excitation as well as detection, it is possible to get a deeper insight into spatio-temporal pattern in living tissues.

Multiparameter Flowfield Measurements in High-Pressure, Cryogenic Environments Using Femtosecond Lasers

NASA Technical Reports Server (NTRS)

Burns, Ross A.; Danehy, Paul M.; Peters, Christopher J.

2016-01-01

Femtosecond laser electronic excitation tagging (FLEET) and Rayleigh scattering (RS) from a femtosecond laser are demonstrated in the NASA Langley 0.3-m Transonic Cryogenic Tunnel (TCT). The measured signals from these techniques are examined for their thermodynamic dependencies in pure nitrogen. The FLEET signal intensity and signal lifetimes are found to scale primarily with the gas density, as does the RS signal. Several models are developed, which capture these physical behaviors. Notably, the FLEET and Rayleigh scattering intensities scale linearly with the flow density, while the FLEET signal decay rates are a more complex function of the thermodynamic state of the gas. The measurement of various flow properties are demonstrated using these techniques. While density was directly measured from the signal intensities and FLEET signal lifetime, temperature and pressure were measured using the simultaneous FLEET velocity measurements while assuming the flow had a constant total enthalpy. Measurements of density, temperature, and pressure from the FLEET signal are made with accuracies as high as 5.3 percent, 0.62 percent, and 6.2 percent, respectively, while precisions were approximately 10 percent, 0.26 percent, and 11 percent for these same quantities. Similar measurements of density from Rayleigh scattering showed an overall accuracy of 3.5 percent and a precision of 10.2 percent over a limited temperature range (T greater than 195 K). These measurements suggest a high degree of utility at using the femtosecond-laser based diagnostics for making multiparameter measurements in high-pressure, cryogenic environments such as large-scale TCT facilities.

Magnetic resonance for laryngeal cancer.

PubMed

Maroldi, Roberto; Ravanelli, Marco; Farina, Davide

2014-04-01

This review summarizes the most recent experiences on the integration of magnetic resonance in assessing the local extent of laryngeal cancer and detecting submucosal recurrences. Advances in magnetic resonance have been characterized by the development of technical solutions that shorten the acquisition time, thereby reducing motion artifacts, and increase the spatial resolution. Phased-array surface coils, directly applied to the neck, enable the use of parallel-imaging techniques, which greatly reduce the acquisition time, and amplify the signal intensity, being closer to the larynx. One of the most important drawbacks of this technique is the small field-of-view, restricting the imaged area to the larynx. Furthermore, diffusion-weighted imaging (DWI) has increased the set of magnetic resonance sequences. Differently from computed tomography (CT), which has only two variables (precontrast/postcontrast), magnetic resonance is based on a multiparameter analysis (T2-weighting and T1-weighting, DWI, and postcontrast acquisition). This multiparameter approach amplifies the contrast resolution. It has, also, permitted to differentiate scar tissue (after laser resection) from submucosal recurrent disease. In addition, DWI sequences have the potential of a more precise discrimination of peritumoral edema from neoplastic tissue, which may lead to improve the assessment of paraglottic space invasion. Magnetic resonance of the larynx is technically challenging. The use of surface coils and motion-reducing techniques is critical to achieve adequate image quality. The intrinsic high-contrast resolution is further increased by the integration of information from different sequences. When CT has not been conclusive, magnetic resonance is indicated in the pretreatment local assessment and in the suspicion of submucosal recurrence.

More on the losses of dissolved CO(2) during champagne serving: toward a multiparameter modeling.

PubMed

Liger-Belair, Gérard; Parmentier, Maryline; Cilindre, Clara

2012-11-28

Pouring champagne into a glass is far from being inconsequential with regard to the dissolved CO(2) concentration found in champagne. Three distinct bottle types, namely, a magnum bottle, a standard bottle, and a half bottle, were examined with regard to their loss of dissolved CO(2) during the service of successively poured flutes. Whatever the bottle size, a decreasing trend is clearly observed with regard to the concentration of dissolved CO(2) found within a flute (from the first to the last one of a whole service). Moreover, when it comes to champagne serving, the bottle size definitely does matter. The higher the bottle volume, the better its buffering capacity with regard to dissolved CO(2) found within champagne during the pouring process. Actually, for a given flute number in a pouring data series, the concentration of dissolved CO(2) found within the flute was found to decrease as the bottle size decreases. The impact of champagne temperature (at 4, 12, and 20 °C) on the losses of dissolved CO(2) found in successively poured flutes for a given standard 75 cL bottle was also examined. Cold temperatures were found to limit the decreasing trend of dissolved CO(2) found within the successively poured flutes (from the first to the last one of a whole service). Our experimental results were discussed on the basis of a multiparameter model that accounts for the major physical parameters that influence the loss of dissolved CO(2) during the service of a whole bottle type.

A novel method for multiparameter physiological phenotype characterization at the single-cell level

NASA Astrophysics Data System (ADS)

Kelbauskas, Laimonas; Ashili, Shashanka; Houkal, Jeff; Smith, Dean; Mohammadreza, Aida; Lee, Kristen; Kumar, Ashok; Anis, Yasser; Paulson, Tom; Youngbull, Cody; Tian, Yanqing; Johnson, Roger; Holl, Mark; Meldrum, Deirdre

2011-02-01

Non-genetic intercellular heterogeneity has been increasingly recognized as one of the key factors in a variety of core cellular processes including proliferation, stimulus response, carcinogenesis and drug resistance. Many diseases, including cancer, originate in a single or a few cells. Early detection and characterization of these abnormal cells can provide new insights into the pathogenesis and serve as a tool for better disease diagnosis and treatment. We report on a novel technology for multiparameter physiological phenotype characterization at the single-cell level. It is based on real-time measurements of concentrations of several metabolites by means of extracellular optical sensors in microchambers of sub-nL volume containing single cells. In its current configuration, the measurement platform features the capability to detect oxygen consumption rate and pH changes under normoxic and hypoxic conditions at the single-cell level. We have conceived, designed and developed a semi-automated method for single-cell manipulation and loading into microwells utilizing custom, high-precision fluid handling at the nanoliter scale. We present the results of a series of measurements of oxygen consumption rates (OCRs) of single human metaplastic esophageal epithelial cells. In addition, to assess the effects of cell-to-cell interactions, we have measured OCRs of two and three cells placed in a single well. The major advantages of the approach are a) multiplexed characterization of cell phenotype at the single-cell level, b) minimal invasiveness due to the distant positioning of sensors, and c) flexibility in terms of accommodating measurements of other metabolites or biomolecules of interest.

A miniaturized and integrated gel post platform for multiparameter PCR detection of herpes simplex viruses from raw genital swabs.

PubMed

Manage, Dammika P; Lauzon, Jana; Atrazhev, Alexey; Morrissey, Yuen C; Edwards, Ann L; Stickel, Alexander J; Crabtree, H John; Pabbaraju, Kanti; Zahariadis, George; Yanow, Stephanie K; Pilarski, Linda M

2012-05-07

Herpes simplex virus (HSV) is one of the most prevalent viruses, with acute and recurrent infections in humans. The current gold standard for the diagnosis of HSV is viral culture which takes 2-14 days and has low sensitivity. In contrast, DNA amplification by polymerase chain reaction (PCR) can be performed within 1-2 h. We here describe a multiparameter PCR assay to simultaneously detect HSV-1 and HSV-2 DNA templates, together with integrated positive and negative controls, with product detection by melting curve analysis (MCA), in an array of semi-solid polyacrylamide gel posts. Each gel post is 0.67 μL in volume, and polymerized with all the components required for PCR. Both PCR and MCA can currently be performed in one hour and 20 min. Unprocessed genital swabs collected in universal transport medium were directly added to the reagents before or after polymerization, diffusing from atop the gel posts. The gel post platform detects HSV templates in as little as 2.5 nL of raw sample. In this study, 45 genital swab specimens were tested blindly as a preliminary validation of this platform. The concordance of PCR on gel posts with conventional PCR was 91%. The primer sequestration method introduced here (wherein different primers are placed in different sets of posts) enables the simultaneous detection of multiple pathogens for the same sample, together with positive and negative controls, on a single chip. This platform accepts unprocessed samples and is readily adaptable to detection of multiple different pathogens or biomarkers for point-of-care diagnostics.

Fabrication of a Miniature Multi-Parameter Sensor Chip for Water Quality Assessment

PubMed Central

Zhou, Bo; Bian, Chao; Tong, Jianhua; Xia, Shanhong

2017-01-01

Water contamination is a main inducement of human diseases. It is an important step to monitor the water quality in the water distribution system. Due to the features of large size, high cost, and complicated structure of traditional water determination sensors and devices, it is difficult to realize real-time water monitoring on a large scale. In this paper, we present a multi-parameter sensor chip, which is miniature, low-cost, and robust, to detect the pH, conductivity, and temperature of water simultaneously. The sensor chip was fabricated using micro-electro-mechanical system (MEMS) techniques. Iridium oxide film was electrodeposited as the pH-sensing material. The atomic ratio of Ir(III) to Ir(IV) is about 1.38 according to the X-ray photoelectron spectroscopy (XPS) analysis. The pH sensing electrode showed super-Nernstian response (−67.60 mV/pH) and good linearity (R2 = 0.9997), in the range of pH 2.22 to pH 11.81. KCl-agar and epoxy were used as the electrolyte layer and liquid junction for the solid-state reference electrode, respectively, and its potential stability in deionized water was 56 h. The conductivity cell exhibited a linear determination range from 21.43 μS/cm to 1.99 mS/cm, and the electrode constant was 1.566 cm−1. Sensitivity of the temperature sensor was 5.46 Ω/°C. The results indicate that the developed sensor chip has potential application in water quality measurements. PMID:28098824

Describing the brain in autism in five dimensions--magnetic resonance imaging-assisted diagnosis of autism spectrum disorder using a multiparameter classification approach.

PubMed

Ecker, Christine; Marquand, Andre; Mourão-Miranda, Janaina; Johnston, Patrick; Daly, Eileen M; Brammer, Michael J; Maltezos, Stefanos; Murphy, Clodagh M; Robertson, Dene; Williams, Steven C; Murphy, Declan G M

2010-08-11

Autism spectrum disorder (ASD) is a neurodevelopmental condition with multiple causes, comorbid conditions, and a wide range in the type and severity of symptoms expressed by different individuals. This makes the neuroanatomy of autism inherently difficult to describe. Here, we demonstrate how a multiparameter classification approach can be used to characterize the complex and subtle structural pattern of gray matter anatomy implicated in adults with ASD, and to reveal spatially distributed patterns of discriminating regions for a variety of parameters describing brain anatomy. A set of five morphological parameters including volumetric and geometric features at each spatial location on the cortical surface was used to discriminate between people with ASD and controls using a support vector machine (SVM) analytic approach, and to find a spatially distributed pattern of regions with maximal classification weights. On the basis of these patterns, SVM was able to identify individuals with ASD at a sensitivity and specificity of up to 90% and 80%, respectively. However, the ability of individual cortical features to discriminate between groups was highly variable, and the discriminating patterns of regions varied across parameters. The classification was specific to ASD rather than neurodevelopmental conditions in general (e.g., attention deficit hyperactivity disorder). Our results confirm the hypothesis that the neuroanatomy of autism is truly multidimensional, and affects multiple and most likely independent cortical features. The spatial patterns detected using SVM may help further exploration of the specific genetic and neuropathological underpinnings of ASD, and provide new insights into the most likely multifactorial etiology of the condition.

"To be or not to be in a good shape": diagnostic and clinical value of nuclear shape irregularities in thyroid and breast cancer.

PubMed

Bussolati, Gianni; Maletta, Francesca; Asioli, Sofia; Annaratone, Laura; Sapino, Anna; Marchiò, Caterina

2014-01-01

Variation in both nuclear shape and size ("pleomorphism"), coupled with changes in chromatin amount and distribution, remains the basic criteria for microscopy in a cytologic diagnosis of cancer. The biological determinants of nuclear shape irregularities are not clarified, so, rather than on the genesis of nuclear irregularities, we here focus our attention on a descriptive analysis of nuclear pleomorphism. We keep in mind that evaluation of nuclear shape as currently practiced in routine preparations is improper because it is indirectly based on the distribution of DNA as revealed by the affinity for basic dyes. Therefore, over the last years we have been using as criteria morphological features of nuclei of thyroid and breast carcinomas as determined by immunofluorescence, in situ hybridization, and 3D reconstruction. We have translated this approach to routine diagnostic pathology on tissue sections by employing immunoperoxidase staining for emerin. Direct detection of nuclear envelope irregularities by tagging nuclear membrane proteins such as lamin B and emerin has resulted in a more objective definition of the shape of the nucleus. In this review we discuss in detail methodological issues as well as diagnostic and prognostic implications provided by decoration/staining of the nuclear envelope in both thyroid and breast cancer, thus demonstrating how much it matters "to be in the right shape" when dealing with pathological diagnosis of cancer.

Intraspecific variation in the turtle barnacle, Cylindrolepas sinica Ren, 1980 (Cirripedia, Thoracica, Coronuloidea), with brief notes on habitat selectivity.

PubMed

Hayashi, Ryota

2013-01-01

Specimens of the turtle barnacle Cylindrolepas sinica Ren, 1980 were collected from sea turtles in Japanese waters. The specimens were hexagonal in shape and were found burrowing into the sea turtle plastron. Specimens were dissected and the hard and soft parts were compared with the original description.

Federal Policies and Higher Education in the United States.

ERIC Educational Resources Information Center

Prisco, Anne; Hurley, Alicia D.; Carton, Thomas C; Richardson, Richard C., Jr.

The purpose of this report is to describe U.S. federal policies that have helped to shape the context within which state systems of higher education operated during the past decade. It also presents descriptive statistics about the higher education enterprise in the United States, including available performance data. The report is based on the…

On Leadership and Fitting in: Dominant Understandings of Masculinities within an Early Primary Peer Group

ERIC Educational Resources Information Center

Keddie, Amanda

2003-01-01

This paper argues the importance of examining the collective dimension of masculinities in the early school years through a description of a study into children's (young males') peer group relations. Specifically, the paper attends to the significance of the peer group in shaping behaviour, and in particular exaggerated "masculine"…

A new western nearctic species of Calameuta konow (Hymenoptera: cephidae)

Treesearch

David R. Smith; Nathan M. Schiff

2005-01-01

Calameuta middlekauffi, n. sp., is described from southern Oregon and California. It is the second species of Calarneuta in North America and is differentiated from C. clnvnta (Norton) by head shape and coloration. Illustrations, descriptions, and a key are given to separate the two species. The food plant is unknown, but Palearctic species of...

Graphical and Numerical Descriptive Analysis: Exploratory Tools Applied to Vietnamese Data

ERIC Educational Resources Information Center

Haughton, Dominique; Phong, Nguyen

2004-01-01

This case study covers several exploratory data analysis ideas, the histogram and boxplot, kernel density estimates, the recently introduced bagplot--a two-dimensional extension of the boxplot--as well as the violin plot, which combines a boxplot with a density shape plot. We apply these ideas and demonstrate how to interpret the output from these…

Listening to Our Students: Understanding How They Learn Research Methods in Geography

ERIC Educational Resources Information Center

Keenan, Kevin; Fontaine, Danielle

2012-01-01

How undergraduate students learn research methods in geography has been understudied. Existing work has focused on course description from the instructor's perspective. This study, however, uses a grounded theory approach to allow students' voices to shape a new theory of how they themselves say that they learn research methods. Data from two…

Shaping the Marketers of Tomorrow: An Analysis of 25 Years of Marketing Education Review

ERIC Educational Resources Information Center

Morrison, Stacey A.; Blair, Amanda J.; McMullan, Kylie L.; Flostrand, Andrew

2017-01-01

This article presents a bibliometric analysis of "Marketing Education Review" from its inception in 1990 until 2014. A brief history of the journal is presented and its content is analyzed. In total, 706 articles were studied in terms of their authorship, manuscript, and content characteristics. Descriptive statistics provide an overview…

Natural Gas: Major Legislative and Regulatory Actions (1935 - 2008)

EIA Publications

2009-01-01

This special report Web-based product presents a chronology of some of the key federal legislative and regulatory actions that have helped shape the natural gas market, with particular emphasis on policy directives from 1978 to October 2008. Separate reports provide brief descriptions of specific legislation, regulations, or policies, and their impacts on the natural gas market.

Stuttering Treatment for a School-Age Child with Down Syndrome: A Descriptive Case Report

ERIC Educational Resources Information Center

Harasym, Jessica; Langevin, Marilyn

2012-01-01

Background: Little is known about optimal treatment approaches and stuttering treatment outcomes for children with Down syndrome. Aims and method: The purpose of this study was to investigate outcomes for a child with Down syndrome who received a combination of fluency shaping therapy and parent delivered contingencies for normally fluent speech,…

Beyond Stereotyping: An Understanding of Sport Media As Sites of Struggle.

ERIC Educational Resources Information Center

Duncan, Margaret Carlisle

Commodification is one of the media mechanisms that shape and proliferate images of femininity which result in the disempowerment of women and of female athletes. The method of homology is used to analyze commodification, one of the formal structures or mechanisms of patriarchy. After a description of this mechanism, the discussion focuses on how…

Controlled Structures Technology Steering Committee Workshop

NASA Technical Reports Server (NTRS)

1992-01-01

Viewgraphs on controlled structures technology presented at the steering committee workshop on 22-23 Jan. 1992 are included. Topics addressed include: interferometer testbed; middeck 0-gravity dynamics experiment; middeck active control experiment; multivariable identification for control; strain actuated aeroelastic control; sensor/actuator technology development; input command shaping; and other research projects. A description of the organization and committee are included.

Gender Differences in the Vocational Interests of Youth Considering High Job Growth and Green Energy Occupations

ERIC Educational Resources Information Center

Robinson, Becky S.

2012-01-01

For more than 100 years, vocational psychologists and educational researchers have sought to identify the significant influences shaping occupational interests. This descriptive study used a series of vocational card sort exercises with 139 rural high school youth to identify gender differences in occupational interests toward working in 60 of the…

A Closer Look at Party Hosting Behaviors within Off-Campus College Settings

ERIC Educational Resources Information Center

Jakeman, Rick C.; McClure, Tracae M.; Silver, Blake R.

2015-01-01

Colleges and universities have taken a variety of approaches to combat alcohol and other drug misuse among students. This descriptive quantitative study aims to investigate the behaviors of students who host off-campus parties and how these behaviors shape party environments. Undergraduate students (N = 2,146) completed an online survey to capture…

The Topological Panorama Camera: A New Tool for Teaching Concepts Related to Space and Time.

ERIC Educational Resources Information Center

Gelphman, Janet L.; And Others

1992-01-01

Included are the description, operating characteristics, uses, and future plans for the Topological Panorama Camera, which is an experimental, robotic photographic device capable of producing visual renderings of the mathematical characteristics of an equation in terms of position changes of an object or in terms of the shape of the space…

Primary Class Size Reduction: How Policy Space, Physical Space, and Spatiality Shape What Happens in Real Schools

ERIC Educational Resources Information Center

Bascia, Nina; Faubert, Brenton

2012-01-01

This article reviews the literature base on class size reduction and proposes a new analytic framework that we believe provides practically useful explanations of how primary class size reduction works. It presents descriptions of classroom practice and grounded explanations for how class size reduction affects educational core activities by…

Dynamics of Shape Memory Alloy Systems, Phase 2

DTIC Science & Technology

2015-12-22

M.A. Savi, S.L.D. Paiva & A.C.P. Brasil Jr., Applied Ecology and Environmental Research, v.11, n.3, pp.463-490, 2013. ISSN 1589-1623. 26...Dynamics and Chaos of the Daisyworld Employed for Global Warming Description", F.M. Viola, M.A. Savi, S.L.D. Paiva & A.C.P. Brasil Jr., Applied Ecology

Students of Color Studying Abroad: A Qualitative Description of the Factors That Influence Participation and the Perceived Impact of Participation

ERIC Educational Resources Information Center

Perkins, Christel

2017-01-01

Research indicates that study abroad participation has many benefits, including increasing students' language proficiency, intercultural sensitivity and cross-cultural communication skills when compared with students who do not study abroad. Additionally, study abroad have been found to shape students' career paths, and academic pursuits. Despite…

Lateral ventricle morphology analysis via mean latitude axis.

PubMed

Paniagua, Beatriz; Lyall, Amanda; Berger, Jean-Baptiste; Vachet, Clement; Hamer, Robert M; Woolson, Sandra; Lin, Weili; Gilmore, John; Styner, Martin

2013-03-29

Statistical shape analysis has emerged as an insightful method for evaluating brain structures in neuroimaging studies, however most shape frameworks are surface based and thus directly depend on the quality of surface alignment. In contrast, medial descriptions employ thickness information as alignment-independent shape metric. We propose a joint framework that computes local medial thickness information via a mean latitude axis from the well-known spherical harmonic (SPHARM-PDM) shape framework. In this work, we applied SPHARM derived medial representations to the morphological analysis of lateral ventricles in neonates. Mild ventriculomegaly (MVM) subjects are compared to healthy controls to highlight the potential of the methodology. Lateral ventricles were obtained from MRI scans of neonates (9-144 days of age) from 30 MVM subjects as well as age- and sex-matched normal controls (60 total). SPHARM-PDM shape analysis was extended to compute a mean latitude axis directly from the spherical parameterization. Local thickness and area was straightforwardly determined. MVM and healthy controls were compared using local MANOVA and compared with the traditional SPHARM-PDM analysis. Both surface and mean latitude axis findings differentiate successfully MVM and healthy lateral ventricle morphology. Lateral ventricles in MVM neonates show enlarged shapes in tail and head. Mean latitude axis is able to find significant differences all along the lateral ventricle shape, demonstrating that local thickness analysis provides significant insight over traditional SPHARM-PDM. This study is the first to precisely quantify 3D lateral ventricle morphology in MVM neonates using shape analysis.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cooper, W. James; Albertson, R Craig; Jacob, Rick E.

Here we present a re-description of Abudefduf luridus and reassign it to the genus Similiparma. We supplement traditional diagnoses and descriptions of this species with quantitative anatomical data collected from a family-wide geometric morphometric analysis of head morphology (44 species representing all 30 damselfish genera) and data from cranial micro-CT scans of fishes in the genus Similiparma. The use of geometric morphometric analyses (and other methods of shape analysis) permits detailed comparisons between the morphology of specific taxa and the anatomical diversity that has arisen in an entire lineage. This provides a particularly useful supplement to traditional description methods andmore » we recommend the use of such techniques by systematists. Similiparma and its close relatives constitute a branch of the damselfish phylogenetic tree that predominantly inhabits rocky reefs in the Atlantic and Eastern Pacific, as opposed to the more commonly studied damselfishes that constitute a large portion of the ichthyofauna on all coral-reef communities.« less

Telidon Videotex presentation level protocol: Augmented picture description instructions

NASA Astrophysics Data System (ADS)

Obrien, C. D.; Brown, H. G.; Smirle, J. C.; Lum, Y. F.; Kukulka, J. Z.; Kwan, A.

1982-02-01

The Telidon Videotex system is a method by which graphic and textual information and transactional services can be accessed from information sources by the general public. In order to transmit information to a Telidon terminal at a minimum bandwidth, and in a manner independent of the type of communications channel, a coding scheme was devised which permits the encoding of a picture into the geometric drawing elements which compose it. These picture description instructions are an alpha geometric coding model and are based on the primitives of POINT, LINE, ARC, RECTANGLE, POLYGON, and INCREMENT. Text is encoded as (ASCII) characters along with a supplementary table of accents and special characters. A mosaic shape table is included for compatibility. A detailed specification of the coding scheme and a description of the principles which make it independent of communications channel and display hardware are provided.

Multiblob coarse-graining for mixtures of long polymers and soft colloids

NASA Astrophysics Data System (ADS)

Locatelli, Emanuele; Capone, Barbara; Likos, Christos N.

2016-11-01

Soft nanocomposites represent both a theoretical and an experimental challenge due to the high number of the microscopic constituents that strongly influence the behaviour of the systems. An effective theoretical description of such systems invokes a reduction of the degrees of freedom to be analysed, hence requiring the introduction of an efficient, quantitative, coarse-grained description. We here report on a novel coarse graining approach based on a set of transferable potentials that quantitatively reproduces properties of mixtures of linear and star-shaped homopolymeric nanocomposites. By renormalizing groups of monomers into a single effective potential between a f-functional star polymer and an homopolymer of length N0, and through a scaling argument, it will be shown how a substantial reduction of the to degrees of freedom allows for a full quantitative description of the system. Our methodology is tested upon full monomer simulations for systems of different molecular weight, proving its full predictive potential.

Qualitative Description of Spatial Quality in Inclusive Architecture.

PubMed

Ryhl, Camilla; Kajita, Masashi; Sørensen, René

2016-01-01

Universal design (UD) has gained global significance and is in the process of institutionalisation in the Nordic Region. This is despite an urgent necessity for developing the theoretical basis and practical applicability of UD. Reflecting this need for furthering the comprehensive understanding of spatial implication of UD, this paper aims to contribute for articulating a means to assess the quality of UD in architecture. Drawing upon numerous cases from research conducted at the Danish Building Research Institute, the paper focuses on sensory aspects of spatial quality, and discusses as well as reflects an applied method for producing the qualitative description of selected buildings that embody UD through creative solutions. The qualitative description of collected examples appears to be effective in delineating sensory aspects of spatial experience; however the systematic development of assessment criteria is essential in order to support students and designers to make responsible decisions in shaping built environments that are accessible and inclusive but also enjoyable.

Shells, orbit bifurcations, and symmetry restorations in Fermi systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Magner, A. G., E-mail: magner@kinr.kiev.ua; Koliesnik, M. V.; Arita, K.

The periodic-orbit theory based on the improved stationary-phase method within the phase-space path integral approach is presented for the semiclassical description of the nuclear shell structure, concerning themain topics of the fruitful activity ofV.G. Soloviev. We apply this theory to study bifurcations and symmetry breaking phenomena in a radial power-law potential which is close to the realistic Woods–Saxon one up to about the Fermi energy. Using the realistic parametrization of nuclear shapes we explain the origin of the double-humped fission barrier and the asymmetry in the fission isomer shapes by the bifurcations of periodic orbits. The semiclassical origin of themore » oblate–prolate shape asymmetry and tetrahedral shapes is also suggested within the improved periodic-orbit approach. The enhancement of shell structures at some surface diffuseness and deformation parameters of such shapes are explained by existence of the simple local bifurcations and new non-local bridge-orbit bifurcations in integrable and partially integrable Fermi-systems. We obtained good agreement between the semiclassical and quantum shell-structure components of the level density and energy for several surface diffuseness and deformation parameters of the potentials, including their symmetry breaking and bifurcation values.« less

Shape sensing methods: Review and experimental comparison on a wing-shaped plate

NASA Astrophysics Data System (ADS)

Gherlone, Marco; Cerracchio, Priscilla; Mattone, Massimiliano

2018-05-01

Shape sensing, i.e., the reconstruction of the displacement field of a structure from some discrete surface strain measurements, is a fundamental capability for the structural health management of critical components. In this paper, a review of the shape sensing methodologies available in the open literature and of the different applications is provided. Then, for the first time, an experimental comparative study is presented among the main approaches in order to highlight their relative merits in presence of uncertainties affecting real applications. These approaches are, namely, the inverse Finite Element Method, the Modal Method and Ko's Displacement Theory. A brief description of these methods is followed by the presentation of the experimental test results. A cantilevered, wing-shaped aluminum plate is let deform under its own weight, leading to bending and twisting. Using the experimental strain measurements as input data, the deflection field of the plate is reconstructed using the three aforementioned approaches and compared with the actual measured deflection. The inverse Finite Element Method is proven to be slightly more accurate and particularly attractive because it is versatile with respect to the boundary conditions and it does not require any information about material properties and loading conditions.

Health and Aging Policy Fellows Program: Shaping a Healthy Future for Older Americans.

PubMed

Pincus, Harold Alan; Pike, Kathleen M; Spaeth-Rublee, Brigitta; Elinson, Lynn

2017-09-01

As the size of the elderly population increases, so do the challenges of and barriers to high-quality, affordable health care. The Health and Aging Policy Fellows (HAPF) Program is designed to provide health and aging professionals with the skills and experience to help lead the effort in reducing these barriers and shaping a healthy and productive future for older Americans. Since its inception in 2008, the program has affected not only the fellows who participate, but also the field of health and aging policy. Work needs to be done to sustain this program so that more fellows can participate and sound policies for the elderly population can continue to be shaped and improved. This report describes the HAPF Program, including its background (rationale, description, partners, progress, effect), lessons learned, challenges and solutions, and policy implications. © 2017, Copyright the Authors Journal compilation © 2017, The American Geriatrics Society.

Moving mode shape function approach for spinning disk and asymmetric disc brake squeal

NASA Astrophysics Data System (ADS)

Kang, Jaeyoung

2018-06-01

The solution approach of an asymmetric spinning disk under stationary friction loads requires the mode shape function fixed in the disk in the assumed mode method when the equations of motion is described in the space-fixed frame. This model description will be termed the 'moving mode shape function approach' and it allows us to formulate the stationary contact load problem in both the axisymmetric and asymmetric disk cases. Numerical results show that the eigenvalues of the time-periodic axisymmetric disk system are time-invariant. When the axisymmetry of the disk is broken, the positive real parts of the eigenvalues highly vary with the rotation of the disk in the slow speeds in such application as disc brake squeal. By using the Floquet stability analysis, it is also shown that breaking the axisymmetry of the disc alters the stability boundaries of the system.

Kinematics of flagellar swimming in Euglena gracilis: Helical trajectories and flagellar shapes.

PubMed

Rossi, Massimiliano; Cicconofri, Giancarlo; Beran, Alfred; Noselli, Giovanni; DeSimone, Antonio

2017-12-12

The flagellar swimming of euglenids, which are propelled by a single anterior flagellum, is characterized by a generalized helical motion. The 3D nature of this swimming motion, which lacks some of the symmetries enjoyed by more common model systems, and the complex flagellar beating shapes that power it make its quantitative description challenging. In this work, we provide a quantitative, 3D, highly resolved reconstruction of the swimming trajectories and flagellar shapes of specimens of Euglena gracilis We achieved this task by using high-speed 2D image recordings taken with a conventional inverted microscope combined with a precise characterization of the helical motion of the cell body to lift the 2D data to 3D trajectories. The propulsion mechanism is discussed. Our results constitute a basis for future biophysical research on a relatively unexplored type of eukaryotic flagellar movement. Copyright © 2017 the Author(s). Published by PNAS.

World Ocean Circulation Experiment

NASA Technical Reports Server (NTRS)

Clarke, R. Allyn

1992-01-01

The oceans are an equal partner with the atmosphere in the global climate system. The World Ocean Circulation Experiment is presently being implemented to improve ocean models that are useful for climate prediction both by encouraging more model development but more importantly by providing quality data sets that can be used to force or to validate such models. WOCE is the first oceanographic experiment that plans to generate and to use multiparameter global ocean data sets. In order for WOCE to succeed, oceanographers must establish and learn to use more effective methods of assembling, quality controlling, manipulating and distributing oceanographic data.

A digital algorithm for spectral deconvolution with noise filtering and peak picking: NOFIPP-DECON

NASA Technical Reports Server (NTRS)

Edwards, T. R.; Settle, G. L.; Knight, R. D.

1975-01-01

Noise-filtering, peak-picking deconvolution software incorporates multiple convoluted convolute integers and multiparameter optimization pattern search. The two theories are described and three aspects of the software package are discussed in detail. Noise-filtering deconvolution was applied to a number of experimental cases ranging from noisy, nondispersive X-ray analyzer data to very noisy photoelectric polarimeter data. Comparisons were made with published infrared data, and a man-machine interactive language has evolved for assisting in very difficult cases. A modified version of the program is being used for routine preprocessing of mass spectral and gas chromatographic data.

Ultrafast optical transistor and router of multi-order fluorescence and spontaneous parametric four-wave mixing in Pr³⁺:YSO.

PubMed

Wen, Feng; Ali, Imran; Hasan, Abdulkhaleq; Li, Changbiao; Tang, Haijun; Zhang, Yufei; Zhang, Yanpeng

2015-10-15

We study the realization of an optical transistor (switch and amplifier) and router in multi-order fluorescence (FL) and spontaneous parametric four-wave mixing (SP-FWM). We estimate that the switching speed is about 15 ns. The router action results from the Autler-Townes splitting in spectral or time domain. The switch and amplifier are realized by dressing suppression and enhancement in FL and SP-FWM. The optical transistor and router can be controlled by multi-parameters (i.e., power, detuning, or polarization).

Vortex conception of rotor and mutual effect of screw/propellers

NASA Technical Reports Server (NTRS)

Lepilkin, A. M.

1986-01-01

A vortex theory of screw/propellers with variable circulation according to the blade and its azimuth is proposed, the problem is formulated and circulation is expanded in a Fourier series. Equations are given for inductive velocities in space for crews, including those with an infinitely large number of blades and expansion of the inductive velocity by blade azimuth of a second screw. Multiparameter improper integrals are given as a combination of elliptical integrals and elementary functions, and it is shown how to reduce elliptical integrals of the third kind with a complex parameter to integrals with a real parameter.

Earth Studies Using L-band Synthetic Aperture Radar

NASA Technical Reports Server (NTRS)

Rosen, Paul A.

1999-01-01

L-band SAR has played an important role in studies of the Earth by revealing the nature of the larger-scale (decimeter) surface features. JERS-1, by supplying multi-seasonal coverage of the much of the earth, has demonstrated the importance of L-band SARs. Future L-band SARs such as ALOS and LightSAR will pave the way for science missions that use SAR instruments. As technology develops to enable lower cost SAR instruments, missions will evolve to each have a unique science focus. International coordination of multi-parameter constellations and campaigns will maximize science return.

Calculation with MCNP of capture photon flux in VVER-1000 experimental reactor.

PubMed

Töre, Candan; Ortego, Pedro

2005-01-01

The aim of this study is to obtain by Monte Carlo method the high energy photon flux due to neutron capture in the internals and vessel layers of the experimental reactor LR-0 located in REZ, Czech Republic, and loaded with VVER-1000 fuel. The calclated neutron, photon and photon to neutron flux ratio are compared with experimental measurements performed with a multi-parameter stilbene detector. The results show clear underestimation of photon flux in downcomer and some overestimation at vessel surface and 1/4 thickness but a good fitting for deeper points in vessel.

Genetically encoded sensors and fluorescence microscopy for anticancer research

NASA Astrophysics Data System (ADS)

Zagaynova, Elena V.; Shirmanova, Marina V.; Sergeeva, Tatiana F.; Klementieva, Natalia V.; Mishin, Alexander S.; Gavrina, Alena I.; Zlobovskay, Olga A.; Furman, Olga E.; Dudenkova, Varvara V.; Perelman, Gregory S.; Lukina, Maria M.; Lukyanov, Konstantin A.

2017-02-01

Early response of cancer cells to chemical compounds and chemotherapeutic drugs were studied using novel fluorescence tools and microscopy techniques. We applied confocal microscopy, two-photon fluorescence lifetime imaging microscopy and super-resolution localization-based microscopy to assess structural and functional changes in cancer cells in vitro. The dynamics of energy metabolism, intracellular pH, caspase-3 activation during staurosporine-induced apoptosis as well as actin cytoskeleton rearrangements under chemotherapy were evaluated. We have showed that new genetically encoded sensors and advanced fluorescence microscopy methods provide an efficient way for multiparameter analysis of cell activities

Optimal pattern synthesis for speech recognition based on principal component analysis

NASA Astrophysics Data System (ADS)

Korsun, O. N.; Poliyev, A. V.

2018-02-01

The algorithm for building an optimal pattern for the purpose of automatic speech recognition, which increases the probability of correct recognition, is developed and presented in this work. The optimal pattern forming is based on the decomposition of an initial pattern to principal components, which enables to reduce the dimension of multi-parameter optimization problem. At the next step the training samples are introduced and the optimal estimates for principal components decomposition coefficients are obtained by a numeric parameter optimization algorithm. Finally, we consider the experiment results that show the improvement in speech recognition introduced by the proposed optimization algorithm.

Theoretical study of polarization dependence of carrier-induced refractive index change of quantum dot.

PubMed

Miao, Qingyuan; Yang, Ziyi; Dong, Jianji; He, Ping-An; Huang, Dexiu

2018-02-05

The influences of dot material component, barrier material component, aspect ratio and carrier density on the refractive index changes of TE mode and TM mode of columnar quantum dot are analyzed, and a multiparameter adjustment method is proposed to realize low polarization dependence of refractive index change. Then the quantum dots with low polarization dependence of refractive index change (<1.5%) within C-band (1530 nm - 1565 nm) are designed, and it shows that quantum dots with different material parameters are anticipated to have similar characteristics of low polarization dependence.

Integrated Multidisciplinary Fault Observation System in the western part of the main Marmara Fault in the frame of an EU-FP7 project, titled as MARSITE

NASA Astrophysics Data System (ADS)

Ozel, Oguz; Guralp, Cansun; Tunc, Suleyman; Yalcinkaya, Esref; Meral Ozel, Nurcan

2015-04-01

The main objective of this study is to install a multi-parameter borehole system and surface array consisting of eight broadband sensors as close to the main Marmara Fault (MMF) in the western Marmara Sea as possible, and measure continuously the evolution of the state of the fault zone surrounding the MMF and to detect any anomaly or change which may occur before earthquakes by making use of the data from these arrays. The multi-parameter borehole system is composed of very wide dynamic range and stable borehole (VBB) broad band seismic sensor, and incorporate 3-D strain meter, tilt meter, and temperature and local hydrostatic pressure measuring devices. All these sensors are installed in 146m-deep borehole. All the sensor outputs are digitized; total of 11*24 bit-channels and 6*20 bit-channels. Real-time data transmission to the main server of the Marsite Project at Kandilli Observatory in Istanbul is accomplished. The multi-parameter borehole seismic station uses the latest update technologies and design ideas to record "Earth tides" signals to the smallest magnitude -3 events, as the innovative part of the Marsite Project. Bringing face to face the seismograms of microearthquakes recorded by borehole and surface instruments portrays quite different contents. The shorter recording duration and nearly flat frequency spectrum up to the Nyquist frequencies of borehole records are faced with longer recording duration and rapid decay of spectral amplitudes at higher frequencies of a surface seismogram. The main causative of the observed differences are near surface geology effects that mask most of the source related information the seismograms include, and that give rise to scattering, generating longer duration seismograms. In view of these circumstances, studies on microearthquakes employing surface seismograms may bring on misleading results. Particularly, the works on earthquake physics and nucleation process of earthquakes requires elaborate analysis of tiny events. It is obvious from the studies on the nucleation process of the 1999 earthquake that tens of minutes before the major rupture initiate noteworthy microearthquake activity happened. The starting point of the 1999 rupture was a site of swarm activity noticed a few decades prior the main shock. Nowadays, analogous case is probable in western Marmara Sea region, prone to a major event in near future where the seismic activity is prevailing along the impending rupture zone. Having deployed a borehole system at the eastern end of the Ganos fault zone will yield invaluable data to closely inspect and monitor the last stages of the preparation stage of major rupture.

Multi-parameter Full-waveform Inversion for Acoustic VTI Medium with Surface Seismic Data

NASA Astrophysics Data System (ADS)

Cheng, X.; Jiao, K.; Sun, D.; Huang, W.; Vigh, D.

2013-12-01

Full-waveform Inversion (FWI) attracts wide attention recently in oil and gas industry as a new promising tool for high resolution subsurface velocity model building. While the traditional common image point gather based tomography method aims to focus post-migrated data in depth domain, FWI aims to directly fit the observed seismic waveform in either time or frequency domain. The inversion is performed iteratively by updating the velocity fields to reduce the difference between the observed and the simulated data. It has been shown the inversion is very sensitive to the starting velocity fields, and data with long offsets and low frequencies is crucial for the success of FWI to overcome this sensitivity. Considering the importance of data with long offsets and low frequencies, in most geologic environment, anisotropy is an unavoidable topic for FWI especially at long offsets, since anisotropy tends to have more pronounced effects on waves traveled for a great distance. In VTI medium, this means more horizontal velocity will be registered in middle-to-long offset data, while more vertical velocity will be registered in near-to-middle offset data. Up to date, most of real world applications of FWI still remain in isotropic medium, and only a few studies have been shown to account for anisotropy. And most of those studies only account for anisotropy in waveform simulation, but not invert for those anisotropy fields. Multi-parameter inversion for anisotropy fields, even in VTI medium, remains as a hot topic in the field. In this study, we develop a strategy for multi-parameter FWI for acoustic VTI medium with surface seismic data. Because surface seismic data is insensitivity to the delta fields, we decide to hold the delta fields unchanged during our inversion, and invert only for vertical velocity and epsilon fields. Through parameterization analysis and synthetic tests, we find that it is more feasible to invert for the parameterization as vertical and horizontal velocities instead of inverting for the parameterization as vertical velocity and epsilon fields. We develop a hierarchical approach to invert for vertical velocity first but hold epsilon unchanged and only switch to simultaneous inversion when vertical velocity inversion are approaching convergence. During simultaneous inversion, we observe significant acceleration in the convergence when incorporates second order information and preconditioning into inversion. We demonstrate the success of our strategy for VTI FWI using synthetic and real data examples from the Gulf of Mexico. Our results show that incorporation of VTI FWI improves migration of large offset acquisition data, and produces better focused migration images to be used in exploration, production and development of oil fields.

A stratigraphic network across the Subtropical Front in the central South Atlantic: Multi-parameter correlation of magnetic susceptibility, density, X-ray fluorescence and @d^1^8O records [rapid communication

NASA Astrophysics Data System (ADS)

Hofmann, Daniela I.; Fabian, Karl; Schmieder, Frank; Donner, Barbara; Bleil, Ulrich

2005-12-01

Computer aided multi-parameter signal correlation is used to develop a common high-precision age model for eight gravity cores from the subtropical and subantarctic South Atlantic. Since correlations between all pairs of multi-parameter sequences are used, and correlation errors between core pairs ( A, B) and ( B, C) are controlled by comparison with ( A, C), the resulting age model is called a stratigraphic network. Precise inter-core correlation is achieved using high-resolution records of magnetic susceptibility κ, wet bulk density ρ and X-ray fluorescence scans of elemental composition. Additional δ18O records are available for two cores. The data indicate nearly undisturbed sediment series and the absence of significant hiatuses or turbidites. After establishing a high-precision common depth scale by synchronously correlating four densely measured parameters (Fe, Ca, κ, ρ), the final age model is obtained by simultaneously fitting the aligned δ18O and κ records of the stratigraphic network to orbitally tuned oxygen isotope [J. Imbrie, J. D. Hays, D. G. Martinson, A. McIntyre, A. C. Mix, J. J. Morley, N. G. Pisias, W. L. Prell, N. J. Shackleton, The orbital theory of Pleistocene climate: support from a revised chronology of the marine δ18O record, in: A. Berger, J. Imbrie, J. Hays, G. Kukla, B. Saltzman (Eds.), Milankovitch and Climate: Understanding the Response to Orbital Forcing, Reidel Publishing, Dordrecht, 1984, pp. 269-305; D. Martinson, N. Pisias, J. Hays, J. Imbrie, T. C. Moore Jr., N. Shackleton, Age dating and the orbital theory of the Ice Ages: development of a high-resolution 0 to 300.000-Year chronostratigraphy, Quat. Res. 27 (1987) 1-29.] or susceptibility stacks [T. von Dobeneck, F.Schmieder, Using rock magnetic proxy records for orbital tuning and extended time series analyses into the super-and sub-Milankovitch Bands, in: G. Fischer, G. Wefer (Eds.), Use of proxies in paleoceanography: Examples from the South Atlantic, Springer-Verlag, Berlin (1999), pp. 601-633.]. Besides the detection and elimination of errors in single records, the stratigraphic network approach allows to check the intrinsic consistency of the final result by comparing it to the outcome of more restricted alignment procedures. The final South Atlantic stratigraphic network covers the last 400 kyr south and the last 1200 kyr north of the Subtropical Front (STF) and provides a highly precise age model across the STF representing extremely different sedimentary regimes. This allows to detect temporal shifts of the STF by mapping δMn / Fe. It turns out that the apparent STF movements by about 200 km are not directly related to marine oxygen isotope stages.

Development of a generalized multi-pixel and multi-parameter satellite remote sensing algorithm for aerosol properties

NASA Astrophysics Data System (ADS)

Hashimoto, M.; Nakajima, T.; Takenaka, H.; Higurashi, A.

2013-12-01

We develop a new satellite remote sensing algorithm to retrieve the properties of aerosol particles in the atmosphere. In late years, high resolution and multi-wavelength, and multiple-angle observation data have been obtained by grand-based spectral radiometers and imaging sensors on board the satellite. With this development, optimized multi-parameter remote sensing methods based on the Bayesian theory have become popularly used (Turchin and Nozik, 1969; Rodgers, 2000; Dubovik et al., 2000). Additionally, a direct use of radiation transfer calculation has been employed for non-linear remote sensing problems taking place of look up table methods supported by the progress of computing technology (Dubovik et al., 2011; Yoshida et al., 2011). We are developing a flexible multi-pixel and multi-parameter remote sensing algorithm for aerosol optical properties. In this algorithm, the inversion method is a combination of the MAP method (Maximum a posteriori method, Rodgers, 2000) and the Phillips-Twomey method (Phillips, 1962; Twomey, 1963) as a smoothing constraint for the state vector. Furthermore, we include a radiation transfer calculation code, Rstar (Nakajima and Tanaka, 1986, 1988), numerically solved each time in iteration for solution search. The Rstar-code has been directly used in the AERONET operational processing system (Dubovik and King, 2000). Retrieved parameters in our algorithm are aerosol optical properties, such as aerosol optical thickness (AOT) of fine mode, sea salt, and dust particles, a volume soot fraction in fine mode particles, and ground surface albedo of each observed wavelength. We simultaneously retrieve all the parameters that characterize pixels in each of horizontal sub-domains consisting the target area. Then we successively apply the retrieval method to all the sub-domains in the target area. We conducted numerical tests for the retrieval of aerosol properties and ground surface albedo for GOSAT/CAI imager data to test the algorithm for the land area. In this test, we simulated satellite-observed radiances for a sub-domain consisting of 5 by 5 pixels by the Rstar code assuming wavelengths of 380, 674, 870 and 1600 [nm], atmospheric condition of the US standard atmosphere, and the several aerosol and ground surface conditions. The result of the experiment showed that AOTs of fine mode and dust particles, soot fraction and ground surface albedo at the wavelength of 674 [nm] are retrieved within absolute value differences of 0.04, 0.01, 0.06 and 0.006 from the true value, respectively, for the case of dark surface, and also, for the case of blight surface, 0.06, 0.03, 0.04 and 0.10 from the true value, respectively. We will conduct more tests to study the information contents of parameters needed for aerosol and land surface remote sensing with different boundary conditions among sub-domains.

Description of the HiMAT Tailored composite structure and laboratory measured vehicle shape under load

NASA Technical Reports Server (NTRS)

Monaghan, R. C.

1981-01-01

The aeroelastically tailored outer wing and canard of the highly maneuverable aircraft technology (HiMAT) vehicle are closely examined and a general description of the overall structure of the vehicle is provided. Test data in the form of laboratory measured twist under load and predicted twist from the HiMAT NASTRAN structural design program are compared. The results of this comparison indicate that the measured twist is generally less than the NASTRAN predicted twist. These discrepancies in twist predictions are attributed, at least in part, to the inability of current analytical composite materials programs to provide sufficiently accurate properties of matrix dominated laminates for input into structural programs such as NASTRAN.

Intraspecific variation in the turtle barnacle, Cylindrolepas sinica Ren, 1980 (Cirripedia, Thoracica, Coronuloidea), with brief notes on habitat selectivity

PubMed Central

Hayashi, Ryota

2013-01-01

Abstract Specimens of the turtle barnacle Cylindrolepas sinica Ren, 1980 were collected from sea turtles in Japanese waters. The specimens were hexagonal in shape and were found burrowing into the sea turtle plastron. Specimens were dissected and the hard and soft parts were compared with the original description. PMID:24167420

Student Sampler: Facts in Brief on North Carolina

ERIC Educational Resources Information Center

North Carolina Department of Public Instruction, 2006

2006-01-01

This student sampler has been compiled to assist North Carolina students (4th and 8th grade) in their study of North Carolina. It is designed to introduce them to the people, places and events that have shaped North Carolina history. Topics include state symbols, descriptions of the state flag, and seal, the lyrics to the state song, and the…

Calibration of the Langley 16-foot transonic tunnel with test section air removal

NASA Technical Reports Server (NTRS)

Corson, B. W., Jr.; Runckel, J. F.; Igoe, W. B.

1974-01-01

The Langley 16-foot transonic tunnel with test section air removal (plenum suction) was calibrated to a Mach number of 1.3. The results of the calibration, including the effects of slot shape modifications, test section wall divergence, and water vapor condensation, are presented. A complete description of the wind tunnel and its auxiliary equipment is included.

Youth Athletes, Bodies and Gender: Gender Constructions in Textbooks Used in Coaching Education Programmes in Sweden

ERIC Educational Resources Information Center

Grahn, Karin

2014-01-01

This paper is based on analyses of ideas about girls and boys in sports as they are presented in textbooks used in coaching education programmes in Sweden. Specifically, it explores gender in relation to descriptions of girls' and boys' bodies and bodily development during puberty. Texts construct gender differences. Masculinity is shaped around…

A Schema-Theoretic View of Reading. Technical Report No. 32.

ERIC Educational Resources Information Center

Adams, Marilyn Jager; Collins, Allan

This paper provides a general description of schema-theoretic models of language comprehension and examines some extensions of such models to the study of reading. The goal of schema theory is to specify the interface between the reader and the text: to specify how the reader's knowledge interacts with and shapes the information on the page and to…

Who Is Shaping the Field? Doctoral Education, Knowledge Creation and Postsecondary Education Research in the United States

ERIC Educational Resources Information Center

Saunders, Daniel B.; Kolek, Ethan A.; Williams, Elizabeth A.; Wells, Ryan S.

2016-01-01

Previous research has found the field of higher education, particularly in the United States, is dominated by functionalist approaches, a preponderance of survey data, and the ubiquitous use of advanced quantitative methods to investigate educational phenomena. This descriptive study aims to illuminate why the field is constructed in this way.…

Engaging Students in Designing Movement: The Divergent Discovery Style of Teaching

ERIC Educational Resources Information Center

Chatoupis, Constantine

2018-01-01

In the divergent discovery style of teaching the teacher designs problems that engage students in finding multiple solutions. The purpose of this article is to show how physical educators can use the divergent discovery style in the gymnasium. A brief description of this style and its connection to the SHAPE America National Standards for K-12…

Recent trends in particle size analysis techniques

NASA Technical Reports Server (NTRS)

Kang, S. H.

1984-01-01

Recent advances and developments in the particle-sizing technologies are briefly reviewed in accordance with three operating principles including particle size and shape descriptions. Significant trends of the particle size analysing equipment recently developed show that compact electronic circuitry and rapid data processing systems were mainly adopted in the instrument design. Some newly developed techniques characterizing the particulate system were also introduced.

ALPS yield optimization cutting program

Treesearch

P. Klinkhachorn; J.P. Franklin; Charles W. McMillin; H.A. Huber

1989-01-01

This paper reports ongoing work on a series of computer programs developed to automate hardwood lumber processing in a furniture roughmill. The program computes the placement of cuttings on lumber, based on a description of each board in terms of shape and defect location, and a cutting bill. These results are suitable for use with a high-power laser to cut the parts...

Continuum description of ionic and dielectric shielding for molecular-dynamics simulations of proteins in solution

NASA Astrophysics Data System (ADS)

Egwolf, Bernhard; Tavan, Paul

2004-01-01

We extend our continuum description of solvent dielectrics in molecular-dynamics (MD) simulations [B. Egwolf and P. Tavan, J. Chem. Phys. 118, 2039 (2003)], which has provided an efficient and accurate solution of the Poisson equation, to ionic solvents as described by the linearized Poisson-Boltzmann (LPB) equation. We start with the formulation of a general theory for the electrostatics of an arbitrarily shaped molecular system, which consists of partially charged atoms and is embedded in a LPB continuum. This theory represents the reaction field induced by the continuum in terms of charge and dipole densities localized within the molecular system. Because these densities cannot be calculated analytically for systems of arbitrary shape, we introduce an atom-based discretization and a set of carefully designed approximations. This allows us to represent the densities by charges and dipoles located at the atoms. Coupled systems of linear equations determine these multipoles and can be rapidly solved by iteration during a MD simulation. The multipoles yield the reaction field forces and energies. Finally, we scrutinize the quality of our approach by comparisons with an analytical solution restricted to perfectly spherical systems and with results of a finite difference method.

Improvements to a method for the geometrically nonlinear analysis of compressively loaded stiffened composite panels

NASA Technical Reports Server (NTRS)

Stoll, Frederick

1993-01-01

The NLPAN computer code uses a finite-strip approach to the analysis of thin-walled prismatic composite structures such as stiffened panels. The code can model in-plane axial loading, transverse pressure loading, and constant through-the-thickness thermal loading, and can account for shape imperfections. The NLPAN code represents an attempt to extend the buckling analysis of the VIPASA computer code into the geometrically nonlinear regime. Buckling mode shapes generated using VIPASA are used in NLPAN as global functions for representing displacements in the nonlinear regime. While the NLPAN analysis is approximate in nature, it is computationally economical in comparison with finite-element analysis, and is thus suitable for use in preliminary design and design optimization. A comprehensive description of the theoretical approach of NLPAN is provided. A discussion of some operational considerations for the NLPAN code is included. NLPAN is applied to several test problems in order to demonstrate new program capabilities, and to assess the accuracy of the code in modeling various types of loading and response. User instructions for the NLPAN computer program are provided, including a detailed description of the input requirements and example input files for two stiffened-panel configurations.

Laser welding of polymers: phenomenological model for a quick and reliable process quality estimation considering beam shape influences

NASA Astrophysics Data System (ADS)

Timpe, Nathalie F.; Stuch, Julia; Scholl, Marcus; Russek, Ulrich A.

2016-03-01

This contribution presents a phenomenological, analytical model for laser welding of polymers which is suited for a quick process quality estimation for the practitioner. Besides material properties of the polymer and processing parameters like welding pressure, feed rate and laser power the model is based on a simple few parameter description of the size and shape of the laser power density distribution (PDD) in the processing zone. The model allows an estimation of the weld seam tensile strength. It is based on energy balance considerations within a thin sheet with the thickness of the optical penetration depth on the surface of the absorbing welding partner. The joining process itself is modelled by a phenomenological approach. The model reproduces the experimentally known process windows for the main process parameters correctly. Using the parameters describing the shape of the laser PDD the critical dependence of the process windows on the PDD shape will be predicted and compared with experiments. The adaption of the model to other laser manufacturing processes where the PDD influence can be modelled comparably will be discussed.

Random, double- and single-strand DNA breaks can be differentiated in the method of Comet assay by the shape of the comet image.

PubMed

Georgieva, Milena; Zagorchev, Plamen; Miloshev, George

2015-10-01

Comet assay is an invaluable tool in DNA research. It is widely used to detect DNA damage as an indicator of exposure to genotoxic stress. A canonical set of parameters and specialized software programs exist for Comet assay data quantification and analysis. None of them so far has proven its potential to employ a computer-based algorithm for assessment of the shape of the comet as an indicator of the exact mechanism by which the studied genotoxins cut in the molecule of DNA. Here, we present 14 unique measurements of the comet image based on the comet morphology. Their mathematical derivation and statistical analysis allowed precise description of the shape of the comet image which in turn discriminated the cause of genotoxic stress. This algorithm led to the development of the "CometShape" software which allowed easy discrimination among different genotoxins depending on the type of DNA damage they induce. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Absolute shape measurements using high-resolution optoelectronic holography methods

NASA Astrophysics Data System (ADS)

Furlong, Cosme; Pryputniewicz, Ryszard J.

2000-01-01

Characterization of surface shape and deformation is of primary importance in a number of testing and metrology applications related to the functionality, performance, and integrity of components. In this paper, a unique, compact, and versatile state-of-the-art fiber-optic-based optoelectronic holography (OEH) methodology is described. This description addresses apparatus and analysis algorithms, especially developed to perform measurements of both absolute surface shape and deformation. The OEH can be arranged in multiple configurations, which include the three-camera, three-illumination, and in-plane speckle correlation setups. With the OEH apparatus and analysis algorithms, absolute shape measurements can be made, using present setup, with a spatial resolution and accuracy of better than 30 and 10 micrometers , respectively, for volumes characterized by a 300-mm length. Optimizing the experimental setup and incorporating equipment, as it becomes available, having superior capabilities to the ones utilized in the present investigations can further increase resolution and accuracy in the measurements. The particular feature of this methodology is its capability to export the measurements data directly into CAD environments for subsequent processing, analysis, and definition of CAD/CAE models.

Measuring the shapes of macromolecules – and why it matters

PubMed Central

Li, Jie; Mach, Paul; Koehl, Patrice

2013-01-01

The molecular basis of life rests on the activity of biological macromolecules, mostly nucleic acids and proteins. A perhaps surprising finding that crystallized over the last handful of decades is that geometric reasoning plays a major role in our attempt to understand these activities. In this paper, we address this connection between geometry and biology, focusing on methods for measuring and characterizing the shapes of macromolecules. We briefly review existing numerical and analytical approaches that solve these problems. We cover in more details our own work in this field, focusing on the alpha shape theory as it provides a unifying mathematical framework that enable the analytical calculations of the surface area and volume of a macromolecule represented as a union of balls, the detection of pockets and cavities in the molecule, and the quantification of contacts between the atomic balls. We have shown that each of these quantities can be related to physical properties of the molecule under study and ultimately provides insight on its activity. We conclude with a brief description of new challenges for the alpha shape theory in modern structural biology. PMID:24688748

A single scan skeletonization algorithm: application to medical imaging of trabecular bone

NASA Astrophysics Data System (ADS)

Arlicot, Aurore; Amouriq, Yves; Evenou, Pierre; Normand, Nicolas; Guédon, Jean-Pierre

2010-03-01

Shape description is an important step in image analysis. The skeleton is used as a simple, compact representation of a shape. A skeleton represents the line centered in the shape and must be homotopic and one point wide. Current skeletonization algorithms compute the skeleton over several image scans, using either thinning algorithms or distance transforms. The principle of thinning is to delete points as one goes along, preserving the topology of the shape. On the other hand, the maxima of the local distance transform identifies the skeleton and is an equivalent way to calculate the medial axis. However, with this method, the skeleton obtained is disconnected so it is required to connect all the points of the medial axis to produce the skeleton. In this study we introduce a translated distance transform and adapt an existing distance driven homotopic algorithm to perform skeletonization with a single scan and thus allow the processing of unbounded images. This method is applied, in our study, on micro scanner images of trabecular bones. We wish to characterize the bone micro architecture in order to quantify bone integrity.

A New Minimum Trees-Based Approach for Shape Matching with Improved Time Computing: Application to Graphical Symbols Recognition

NASA Astrophysics Data System (ADS)

Franco, Patrick; Ogier, Jean-Marc; Loonis, Pierre; Mullot, Rémy

Recently we have developed a model for shape description and matching. Based on minimum spanning trees construction and specifics stages like the mixture, it seems to have many desirable properties. Recognition invariance in front shift, rotated and noisy shape was checked through median scale tests related to GREC symbol reference database. Even if extracting the topology of a shape by mapping the shortest path connecting all the pixels seems to be powerful, the construction of graph induces an expensive algorithmic cost. In this article we discuss on the ways to reduce time computing. An alternative solution based on image compression concepts is provided and evaluated. The model no longer operates in the image space but in a compact space, namely the Discrete Cosine space. The use of block discrete cosine transform is discussed and justified. The experimental results led on the GREC2003 database show that the proposed method is characterized by a good discrimination power, a real robustness to noise with an acceptable time computing.

Two-dimensional shape classification using generalized Fourier representation and neural networks

NASA Astrophysics Data System (ADS)

Chodorowski, Artur; Gustavsson, Tomas; Mattsson, Ulf

2000-04-01

A shape-based classification method is developed based upon the Generalized Fourier Representation (GFR). GFR can be regarded as an extension of traditional polar Fourier descriptors, suitable for description of closed objects, both convex and concave, with or without holes. Explicit relations of GFR coefficients to regular moments, moment invariants and affine moment invariants are given in the paper. The dual linear relation between GFR coefficients and regular moments was used to compare shape features derive from GFR descriptors and Hu's moment invariants. the GFR was then applied to a clinical problem within oral medicine and used to represent the contours of the lesions in the oral cavity. The lesions studied were leukoplakia and different forms of lichenoid reactions. Shape features were extracted from GFR coefficients in order to classify potentially cancerous oral lesions. Alternative classifiers were investigated based on a multilayer perceptron with different architectures and extensions. The overall classification accuracy for recognition of potentially cancerous oral lesions when using neural network classifier was 85%, while the classification between leukoplakia and reticular lichenoid reactions gave 96% (5-fold cross-validated) recognition rate.

Prediction of the shapes of deformed nuclei by the polyspheron theory.

PubMed

Pauling, L

1982-04-01

It is pointed out that some features of the shapes of (62) (154)Sm, (68) (166)Er, and (70) (176)Yb as reported by Cooper et al. [Cooper, T., Bertozzi, W., Heisenberg, J., Kowalski, S., Turchinetz, W., Williamson, C., Cardman, L., Fivozinsky, S., Lightbody, J., Jr., & Penner, S. (1976) Phys. Rev. C 13, 1083-1094] from electron-scattering experiments agree reasonably well with the description of these nuclei, derived from the values of the rotational energy levels, as consisting of a large spherical part (essentially (132)Sn) and a cap [Pauling, L. (1969) Proc. Natl. Acad. Sci. USA 64, 807-809; Pauling, L. & Robinson, A. B. (1975) Can. J. Phys. 53, 1953-1964].

Elongated dust particles growth in a spherical glow discharge in ethanol

NASA Astrophysics Data System (ADS)

Fedoseev, A. V.; Sukhinin, G. I.; Sakhapov, S. Z.; Zaikovskii, A. V.; Novopashin, S. A.

2018-01-01

The formation of elongated dust particles in a spherical dc glow discharge in ethanol was observed for the first time. Dust particles were formed in the process of coagulation of ethanol dissociation products in the plasma of gas discharge. During the process the particles were captured into clouds in the electric potential wells of strong striations of spherical discharge. The size and the shape of dust particles are easily detected by naked eye after the illumination of the laser sheet. The description of the experimental setup and conditions, the analysis of size, shape and composition of the particles, the explanation of spatial ordering and orientation of these particles are presented.

Prediction of the shapes of deformed nuclei by the polyspheron theory

PubMed Central

Pauling, Linus

1982-01-01

It is pointed out that some features of the shapes of 62154Sm, 68166Er, and 70176Yb as reported by Cooper et al. [Cooper, T., Bertozzi, W., Heisenberg, J., Kowalski, S., Turchinetz, W., Williamson, C., Cardman, L., Fivozinsky, S., Lightbody, J., Jr., & Penner, S. (1976) Phys. Rev. C 13, 1083-1094] from electron-scattering experiments agree reasonably well with the description of these nuclei, derived from the values of the rotational energy levels, as consisting of a large spherical part (essentially 132Sn) and a cap [Pauling, L. (1969) Proc. Natl. Acad. Sci. USA 64, 807-809; Pauling, L. & Robinson, A. B. (1975) Can. J. Phys. 53, 1953-1964]. Images PMID:16593183

Locomotion of C. elegans: A Piecewise-Harmonic Curvature Representation of Nematode Behavior

PubMed Central

Padmanabhan, Venkat; Khan, Zeina S.; Solomon, Deepak E.; Armstrong, Andrew; Rumbaugh, Kendra P.; Vanapalli, Siva A.; Blawzdziewicz, Jerzy

2012-01-01

Caenorhabditis elegans, a free-living soil nematode, displays a rich variety of body shapes and trajectories during its undulatory locomotion in complex environments. Here we show that the individual body postures and entire trails of C. elegans have a simple analytical description in curvature representation. Our model is based on the assumption that the curvature wave is generated in the head segment of the worm body and propagates backwards. We have found that a simple harmonic function for the curvature can capture multiple worm shapes during the undulatory movement. The worm body trajectories can be well represented in terms of piecewise sinusoidal curvature with abrupt changes in amplitude, wavevector, and phase. PMID:22792224

Spinning superfluid 4He nanodroplets

NASA Astrophysics Data System (ADS)

Ancilotto, Francesco; Barranco, Manuel; Pi, Martí

2018-05-01

We have studied spinning superfluid 4He nanodroplets at zero temperature using density functional theory. Due to the irrotational character of the superfluid flow, the shapes of the spinning nanodroplets are very different from those of a viscous normal fluid drop in steady rotation. We show that when vortices are nucleated inside the superfluid droplets, their morphology, which evolves from axisymmetric oblate to triaxial prolate to two-lobed shapes, is in good agreement with experiments. The presence of vortex arrays confers to the superfluid droplets the rigid-body behavior of a normal fluid in steady rotation, and this is the ultimate reason for the surprising good agreement between recent experiments and the classical models used for their description.

Does the Sole Description of a Tax Authority Affect Tax Evasion? - The Impact of Described Coercive and Legitimate Power

PubMed Central

Hartl, Barbara; Hofmann, Eva; Gangl, Katharina; Hartner-Tiefenthaler, Martina; Kirchler, Erich

2015-01-01

Following the classic economic model of tax evasion, taxpayers base their tax decisions on economic determinants, like fine rate and audit probability. Empirical findings on the relationship between economic key determinants and tax evasion are inconsistent and suggest that taxpayers may rather rely on their beliefs about tax authority’s power. Descriptions of the tax authority’s power may affect taxpayers’ beliefs and as such tax evasion. Experiment 1 investigates the impact of fines and beliefs regarding tax authority’s power on tax evasion. Experiments 2-4 are conducted to examine the effect of varying descriptions about a tax authority’s power on participants’ beliefs and respective tax evasion. It is investigated whether tax evasion is influenced by the description of an authority wielding coercive power (Experiment 2), legitimate power (Experiment 3), and coercive and legitimate power combined (Experiment 4). Further, it is examined whether a contrast of the description of power (low to high power; high to low power) impacts tax evasion (Experiments 2-4). Results show that the amount of fine does not impact tax payments, whereas participants’ beliefs regarding tax authority’s power significantly shape compliance decisions. Descriptions of high coercive power as well as high legitimate power affect beliefs about tax authority’s power and positively impact tax honesty. This effect still holds if both qualities of power are applied simultaneously. The contrast of descriptions has little impact on tax evasion. The current study indicates that descriptions of the tax authority, e.g., in information brochures and media reports, have more influence on beliefs and tax payments than information on fine rates. Methodically, these considerations become particularly important when descriptions or vignettes are used besides objective information. PMID:25923770

Does the sole description of a tax authority affect tax evasion?--the impact of described coercive and legitimate power.

PubMed

Hartl, Barbara; Hofmann, Eva; Gangl, Katharina; Hartner-Tiefenthaler, Martina; Kirchler, Erich

2015-01-01

Following the classic economic model of tax evasion, taxpayers base their tax decisions on economic determinants, like fine rate and audit probability. Empirical findings on the relationship between economic key determinants and tax evasion are inconsistent and suggest that taxpayers may rather rely on their beliefs about tax authority's power. Descriptions of the tax authority's power may affect taxpayers' beliefs and as such tax evasion. Experiment 1 investigates the impact of fines and beliefs regarding tax authority's power on tax evasion. Experiments 2-4 are conducted to examine the effect of varying descriptions about a tax authority's power on participants' beliefs and respective tax evasion. It is investigated whether tax evasion is influenced by the description of an authority wielding coercive power (Experiment 2), legitimate power (Experiment 3), and coercive and legitimate power combined (Experiment 4). Further, it is examined whether a contrast of the description of power (low to high power; high to low power) impacts tax evasion (Experiments 2-4). Results show that the amount of fine does not impact tax payments, whereas participants' beliefs regarding tax authority's power significantly shape compliance decisions. Descriptions of high coercive power as well as high legitimate power affect beliefs about tax authority's power and positively impact tax honesty. This effect still holds if both qualities of power are applied simultaneously. The contrast of descriptions has little impact on tax evasion. The current study indicates that descriptions of the tax authority, e.g., in information brochures and media reports, have more influence on beliefs and tax payments than information on fine rates. Methodically, these considerations become particularly important when descriptions or vignettes are used besides objective information.

Arabidopsis phenotyping through Geometric Morphometrics.

PubMed

Manacorda, Carlos A; Asurmendi, Sebastian

2018-06-18

Recently, much technical progress was achieved in the field of plant phenotyping. High-throughput platforms and the development of improved algorithms for rosette image segmentation make it now possible to extract shape and size parameters for genetic, physiological and environmental studies on a large scale. The development of low-cost phenotyping platforms and freeware resources make it possible to widely expand phenotypic analysis tools for Arabidopsis. However, objective descriptors of shape parameters that could be used independently of platform and segmentation software used are still lacking and shape descriptions still rely on ad hoc or even sometimes contradictory descriptors, which could make comparisons difficult and perhaps inaccurate. Modern geometric morphometrics is a family of methods in quantitative biology proposed to be the main source of data and analytical tools in the emerging field of phenomics studies. Based on the location of landmarks (corresponding points) over imaged specimens and by combining geometry, multivariate analysis and powerful statistical techniques, these tools offer the possibility to reproducibly and accurately account for shape variations amongst groups and measure them in shape distance units. Here, a particular scheme of landmarks placement on Arabidopsis rosette images is proposed to study shape variation in the case of viral infection processes. Shape differences between controls and infected plants are quantified throughout the infectious process and visualized. Quantitative comparisons between two unrelated ssRNA+ viruses are shown and reproducibility issues are assessed. Combined with the newest automated platforms and plant segmentation procedures, geometric morphometric tools could boost phenotypic features extraction and processing in an objective, reproducible manner.

The design and implementation of stereoscopic 3D scalable vector graphics based on WebKit

NASA Astrophysics Data System (ADS)

Liu, Zhongxin; Wang, Wenmin; Wang, Ronggang

2014-03-01

Scalable Vector Graphics (SVG), which is a language designed based on eXtensible Markup Language (XML), is used to describe basic shapes embedded in webpages, such as circles and rectangles. However, it can only depict 2D shapes. As a consequence, web pages using classical SVG can only display 2D shapes on a screen. With the increasing development of stereoscopic 3D (S3D) technology, binocular 3D devices have been widely used. Under this circumstance, we intend to extend the widely used web rendering engine WebKit to support the description and display of S3D webpages. Therefore, the extension of SVG is of necessity. In this paper, we will describe how to design and implement SVG shapes with stereoscopic 3D mode. Two attributes representing the depth and thickness are added to support S3D shapes. The elimination of hidden lines and hidden surfaces, which is an important process in this project, is described as well. The modification of WebKit is also discussed, which is made to support the generation of both left view and right view at the same time. As is shown in the result, in contrast to the 2D shapes generated by the Google Chrome web browser, the shapes got from our modified browser are in S3D mode. With the feeling of depth and thickness, the shapes seem to be real 3D objects away from the screen, rather than simple curves and lines as before.

Application of the Hartmann-Tran profile to analysis of H2O spectra

NASA Astrophysics Data System (ADS)

Lisak, D.; Cygan, A.; Bermejo, D.; Domenech, J. L.; Hodges, J. T.; Tran, H.

2015-10-01

The Hartmann-Tran profile (HTP), which has been recently recommended as a new standard in spectroscopic databases, is used to analyze spectra of several lines of H2O diluted in N2, SF6, and in pure H2O. This profile accounts for various mechanisms affecting the line-shape and can be easily computed in terms of combinations of the complex Voigt profile. A multi-spectrum fitting procedure is implemented to simultaneously analyze spectra of H2O transitions acquired at different pressures. Multi-spectrum fitting of the HTP to a theoretical model confirms that this profile provides an accurate description of H2O line-shapes in terms of residuals and accuracy of fitted parameters. This profile and its limiting cases are also fit to measured spectra for three H2O lines in different vibrational bands. The results show that it is possible to obtain accurate HTP line-shape parameters when measured spectra have a sufficiently high signal-to-noise ratio and span a broad range of collisional-to-Doppler line widths. Systematic errors in the line area and differences in retrieved line-shape parameters caused by the overly simplistic line-shape models are quantified. Also limitations of the quadratic speed-dependence model used in the HTP are demonstrated in the case of an SF6 broadened H2O line, which leads to a strongly asymmetric line-shape.

The Organization of Shape and Color in Vision and Art

PubMed Central

Pinna, Baingio

2011-01-01

The aim of this work is to study the phenomenal organization of shape and color in vision and art in terms of microgenesis of the object perception and creation. The idea of “microgenesis” is that the object perception and creation takes time to develop. Our hypothesis is that the roles of shape and color are extracted in sequential order and in the same order these roles are also used by artists to paint objects. Boundary contours are coded before color contours. The microgenesis of the object formation was demonstrated (i) by introducing new conditions derived from the watercolor illusion, where the juxtaposed contours are displaced horizontally or vertically, and based on variations of Matisse’s Woman, (ii) by studying descriptions and replications of visual objects in adults and children of different ages, and (iii) by analyzing the linguistic sequence and organization in a free naming task of the attributes related to shape and color. The results supported the idea of the microgenesis of the object perception, namely the temporal order in the formation of the roles of the object properties (shape before color). Some general principles were extracted from the experimental results. They can be a starting point to explore a new domain focused on the microgenesis of shape and color within the more general problem of object organization, where integrated and multidisciplinary studies based on art and vision science can be very useful. PMID:22065954

[Application of the elliptic fourier functions to the description of avian egg shape].

PubMed

Ávila, Dennis Denis

2014-12-01

Egg shape is difficult to quantify due to the lack of an exact formula to describe its geometry. Here I described a simple algorithm to characterize and compare egg shapes using Fourier functions. These functions can delineate any closed contour and had been previously applied to describe several biological objects. I described, step by step, the process of data acquisition, processing and the use of the SHAPE software to extract function coefficients in a study case. I compared egg shapes in three birds' species representing different reproductive strategies: Cuban Parakeet (Aratinga euops), Royal Tern (Thalasseus maximus) and Cuban Blackbird (Dives atroviolaceus). Using 73 digital pictures of eggs kept in Cuban scientific collections, I calculated Fourier descriptors with 4, 6, 8, 16 and 20 harmonics. Descriptors were reduced by a Principal Component Analysis and the scores of the eigen-values that account for 90% of variance were used in a Lineal Discriminant Function to analyze the possibility to differentiate eggs according to its shapes. Using four harmonics, the first five component accounted for 97% of shape variances; more harmonics diluted the variance increasing to eight the number of components needed to explain most of the variation. Convex polygons in the discriminant space showed a clear separation between species, allowing trustful discrimination (classification errors between 7-15%). Misclassifications were related to specific egg shape variability between species. In the study case, A. euops eggs were perfectly classified, but for the other species, errors ranged from 5 to 29% of misclassifications, in relation to the numbers or harmonics and components used. The proposed algorithm, despite its apparent mathematical complexity, showed many advantages to describe eggs shape allowing a deeper understanding of factors related to this variable.

Shape of the orbital opening: individual characterization and analysis of variability in modern humans, Gorilla gorilla, and Pan troglodytes.

PubMed

Schmittbuhl, M; Le Minor, J M; Allenbach, B; Schaaf, A

1999-05-01

The description of the human orbital shape is principally qualitative in the classical literature, and characterised by adjectives such as circular, rectangular or quadrangular. In order to provide a precise quantification and interpretation of this shape, a study based on automatic image analysis and Fourier analysis was carried out on 45 human skulls (30 males, 15 females), and for comparison on 61 skulls of Gorilla gorilla (40 males, 21 females), and 34 skulls of Pan troglodytes (20 males, 14 females). Sexual dimorphism in the shape of the orbital opening was not demonstrated. Its dominant morphological features could be characterized by Fourier analysis; elliptical elongation and quadrangularity were dominant morphological features of the shape of the orbital opening in the three species. Elliptical elongation was more marked in humans and Pan, whereas quadrangularity was particularly emphasized in Gorilla. An intraspecific variability of the shape of the orbital opening existed in humans, Gorilla and Pan, and seemed close in the three species. Interspecific partition between humans, Gorilla and Pan was demonstrated despite the variability observed in the three species studied. Interspecific differences between Gorilla and the Pan-humans group were principally explained by the differences in quadrangularity, and by differences in orientation of triangularity and pentagonality. Differences in the shape of the orbital opening between humans and Pan were principally explained by differences in hexagonality, and by differences in orientation of quadrangularity. A closeness of shape between some humans and some individuals in Pan and, to a lesser degree, with some individuals in Gorilla was observed, demonstrating the existence of a morphological continuum of the shape of the orbital opening in hominoids.

Inertia-Centric Stability Analysis of a Planar Uniform Dust Molecular Cloud with Weak Neutral-Charged Dust Frictional Coupling

NASA Astrophysics Data System (ADS)

K. Karmakar, P.; Borah, B.

2014-05-01

This paper adopts an inertia-centric evolutionary model to study the excitation mechanism of new gravito-electrostatic eigenmode structures in a one-dimensional (1-D) planar self-gravitating dust molecular cloud (DMC) on the Jeans scale. A quasi-neutral multi-fluid consisting of warm electrons, warm ions, neutral gas and identical inertial cold dust grains with partial ionization is considered. The grain-charge is assumed not to vary at the fluctuation evolution time scale. The neutral gas particles form the background, which is weakly coupled with the collapsing grainy plasma mass. The gravitational decoupling of the background neutral particles is justifiable for a higher inertial mass of the grains with higher neutral population density so that the Jeans mode frequency becomes reasonably large. Its physical basis is the Jeans assumption of a self-gravitating uniform medium adopted for fiducially analytical simplification by neglecting the zero-order field. So, the equilibrium is justifiably treated initially as “homogeneous”. The efficacious inertial role of the thermal species amidst weak collisions of the neutral-charged grains is taken into account. A standard multiscale technique over the gravito-electrostatic equilibrium yields a unique pair of Korteweg-de Vries (KdV) equations. It is integrated numerically by the fourth-order Runge-Kutta method with multi-parameter variation for exact shape analyses. Interestingly, the model is conducive for the propagation of new conservative solitary spectral patterns. Their basic physics, parametric features and unique characteristics are discussed. The results go qualitatively in good correspondence with the earlier observations made by others. Tentative applications relevant to space and astrophysical environments are concisely highlighted.

High-rate dead-time corrections in a general purpose digital pulse processing system

PubMed Central

Abbene, Leonardo; Gerardi, Gaetano

2015-01-01

Dead-time losses are well recognized and studied drawbacks in counting and spectroscopic systems. In this work the abilities on dead-time correction of a real-time digital pulse processing (DPP) system for high-rate high-resolution radiation measurements are presented. The DPP system, through a fast and slow analysis of the output waveform from radiation detectors, is able to perform multi-parameter analysis (arrival time, pulse width, pulse height, pulse shape, etc.) at high input counting rates (ICRs), allowing accurate counting loss corrections even for variable or transient radiations. The fast analysis is used to obtain both the ICR and energy spectra with high throughput, while the slow analysis is used to obtain high-resolution energy spectra. A complete characterization of the counting capabilities, through both theoretical and experimental approaches, was performed. The dead-time modeling, the throughput curves, the experimental time-interval distributions (TIDs) and the counting uncertainty of the recorded events of both the fast and the slow channels, measured with a planar CdTe (cadmium telluride) detector, will be presented. The throughput formula of a series of two types of dead-times is also derived. The results of dead-time corrections, performed through different methods, will be reported and discussed, pointing out the error on ICR estimation and the simplicity of the procedure. Accurate ICR estimations (nonlinearity < 0.5%) were performed by using the time widths and the TIDs (using 10 ns time bin width) of the detected pulses up to 2.2 Mcps. The digital system allows, after a simple parameter setting, different and sophisticated procedures for dead-time correction, traditionally implemented in complex/dedicated systems and time-consuming set-ups. PMID:26289270

Validation of an In-Water, Tower-Shading Correction Scheme

NASA Technical Reports Server (NTRS)

Hooker, Stanford B. (Editor); Firestone, Elaine R. (Editor); Doyle, John P.; Zibordi, Giuseppe; vanderLinde, Dirk

2003-01-01

Large offshore structures used for the deployment of optical instruments can significantly perturb the intensity of the light field surrounding the optical measurement point, where different portions of the visible spectrum are subject to different shadowing effects. These effects degrade the quality of the acquired optical data and can reduce the accuracy of several derived quantities, such as those obtained by applying bio-optical algorithms directly to the shadow-perturbed data. As a result, optical remote sensing calibration and validation studies can be impaired if shadowing artifacts are not fully accounted for. In this work, the general in-water shadowing problem is examined for a particular case study. Backward Monte Carlo (MC) radiative transfer computations- performed in a vertically stratified, horizontally inhomogeneous, and realistic ocean-atmosphere system are shown to accurately simulate the shadow-induced relative percent errors affecting the radiance and irradiance data profiles acquired close to an oceanographic tower. Multiparameter optical data processing has provided adequate representation of experimental uncertainties allowing consistent comparison with simulations. The more detailed simulations at the subsurface depth appear to be essentially equivalent to those obtained assuming a simplified ocean-atmosphere system, except in highly stratified waters. MC computations performed in the simplified system can be assumed, therefore, to accurately simulate the optical measurements conducted under more complex sampling conditions (i.e., within waters presenting moderate stratification at most). A previously reported correction scheme, based on the simplified MC simulations, and developed for subsurface shadow-removal processing of in-water optical data taken close to the investigated oceanographic tower, is then validated adequately under most experimental conditions. It appears feasible to generalize the present tower-specific approach to solve other optical sensor shadowing problems pertaining to differently shaped deployment platforms, and also including surrounding structures and instrument casings.

Natural descriptions of motor behavior: examples from E. coli and C. elegans.

NASA Astrophysics Data System (ADS)

Ryu, William

2007-03-01

E. coli has a natural behavioral variable - the direction of rotation of its flagellar rotorary motor. Monitoring this one-dimensional behavioral response in reaction to chemical perturbation has been instrumental in the understanding of how E. coli performs chemotaxis at the genetic, physiological, and computational level. Here we apply this experimental strategy to the study of bacterial thermotaxis - a sensory mode that is less well understood. We investigate bacterial thermosensation by studying the motor response of single cells subjected to impulses of heat produced by an IR laser. A simple temperature dependent modification to an existing chemotaxis model can explain the observed temperature response. Higher organisms may have a more complicated behavioral response due to the simple fact that their motions have more degrees of freedom. Here we provide a principled analysis of motor behavior of such an organism -- the roundworm C. elegans. Using tracking video-microscopy we capture a worm's image and extract the skeleton of the shape as a head-to-tail ordered collection of tangent angles sampled along the curve. Applying principal components analysis we show that the space of shapes is remarkably low dimensional, with four dimensions accounting for > 95% of the shape variance. We also show that these dimensions align with behaviorally relevant states. As an application of this analysis we study the thermal response of worms stimulated by laser heating. Our quantitative description of C. elegans movement should prove useful in a wide variety of contexts, from the linking of motor output with neural circuitry to the genetic basis of adaptive behavior.

Description of the lower jaws of Baculites from the Upper Cretaceous U.S. Western Interior

NASA Astrophysics Data System (ADS)

Larson, Neal L.; Landman, Neil H.

2017-03-01

We report the discovery of lower jaws of Baculites (Ammonoidea) from the Upper Cretaceous U.S. Western Interior. In the lower Campanian Smoky Hill Chalk Member of the Niobrara Chalk of Kansas, most of the jaws occur as isolated elements. Based on their age, they probably belong to Baculites sp. (smooth). They conform to the description of rugaptychus, and are ornamented with coarse rugae on their ventral side. One specimen is preserved inside a small fecal pellet that was probably produced by a fish. Another specimen occurs inside in a crushed body chamber near the aperture and is probably in situ. Three small structures are present immediately behind the jaw and may represent the remains of the gills. In the lower Maastrichtian Pierre Shale of Wyoming, two specimens of Baculites grandis contain lower jaws inside their body chambers, and are probably in situ. In both specimens, the jaws are oriented at an acute angle to the long axis of the shell, with their anterior ends pointing toward the dorsum. One of the jaws is folded into a U-shape, which probably approximates the shape of the jaw during life. Based on the measurements of the jaws and the shape of the shell, the jaws could not have touched the sides of the shell even if they were splayed out, implying that they could not have effectively served as opercula. Instead, in combination with the upper jaws and radula, they constituted the buccal apparatus that collected and conveyed food to the esophagus.

Effects of velocity-changing collisions on two-photon and stepwise-absorption spectroscopic line shapes

NASA Astrophysics Data System (ADS)

Liao, P. F.; Bjorkholm, J. E.; Berman, P. R.

1980-06-01

We report the results of an experimental study of the effects of velocity-changing collisions on two-photon and stepwise-absorption line shapes. Excitation spectra for the 3S12-->3P12-->4D12 transitions of sodium atoms undergoing collisions with foreign gas perturbers are obtained. These spectra are obtained with two cw dye lasers. One laser, the pump laser, is tuned 1.6 GHz below the 3S12-->3P12 transition frequency and excites a nonthermal longitudinal velocity distribution of excited 3P12 atoms in the vapor. Absorption of the second (probe) laser is used to monitor the steady-state excited-state distribution which is a result of collisions with rare gas atoms. The spectra are obtained for various pressures of He, Ne, and Kr gases and are fit to a theoretical model which utilizes either the phenomenological Keilson-Störer or the classical hardsphere collision kernel. The theoretical model includes the effects of collisionally aided excitation of the 3P12 state as well as effects due to fine-structure state-changing collisions. Although both kernels are found to predict line shapes which are in reasonable agreement with the experimental results, the hard-sphere kernel is found superior as it gives a better description of the effects of large-angle scattering for heavy perturbers. Neither kernel provides a fully adequate description over the entire line profile. The experimental data is used to extract effective hard-sphere collision cross sections for collisions between sodium 3P12 atoms and helium, neon, and krypton perturbers.

A tailored 200 parameter VME based data acquisition system for IBA at the Lund Ion Beam Analysis Facility - Hardware and software

NASA Astrophysics Data System (ADS)

Elfman, Mikael; Ros, Linus; Kristiansson, Per; Nilsson, E. J. Charlotta; Pallon, Jan

2016-03-01

With the recent advances towards modern Ion Beam Analysis (IBA), going from one- or few-parameter detector systems to multi-parameter systems, it has been necessary to expand and replace the more than twenty years old CAMAC based system. A new VME multi-parameter (presently up to 200 channels) data acquisition and control system has been developed and implemented at the Lund Ion Beam Analysis Facility (LIBAF). The system is based on the VX-511 Single Board Computer (SBC), acting as master with arbiter functionality and consists of standard VME modules like Analog to Digital Converters (ADC's), Charge to Digital Converters (QDC's), Time to Digital Converters (TDC's), scaler's, IO-cards, high voltage and waveform units. The modules have been specially selected to support all of the present detector systems in the laboratory, with the option of future expansion. Typically, the detector systems consist of silicon strip detectors, silicon drift detectors and scintillator detectors, for detection of charged particles, X-rays and γ-rays. The data flow of the raw data buffers out from the VME bus to the final storage place on a 16 terabyte network attached storage disc (NAS-disc) is described. The acquisition process, remotely controlled over one of the SBCs ethernet channels, is also discussed. The user interface is written in the Kmax software package, and is used to control the acquisition process as well as for advanced online and offline data analysis through a user-friendly graphical user interface (GUI). In this work the system implementation, layout and performance are presented. The user interface and possibilities for advanced offline analysis are also discussed and illustrated.

Effects of variation in cerebral haemodynamics during aneurysm surgery on brain tissue oxygen and metabolism.

PubMed

Kett-White, R; Hutchinson, P J; Czosnyka, M; al-Rawi, P; Gupta, A; Pickard, J D; Kirkpatrick, P J

2002-01-01

This study explores the sensitivities of multiparameter tissue gas sensors and microdialysis to variations in blood pressure, CSF drainage and to well-defined periods of ischaemia accompanying aneurysm surgery, and their predictive value for infarction. A Neurotrend sensor [brain tissue partial pressure of oxygen (PBO2), carbon dioxide (PBCO2), brain pH (pHB) and temperature] and microdialysis catheter were inserted into the appropriate vascular territory prior to craniotomy. Baseline data showed a clear correlation between PBO2 and mean arterial pressure (MAP) below a threshold of 80 mmHg. PBO2 improved with CSF drainage in 20 out of 28 (Wilcoxon: P < 0.05) cases where data was available. In 26 patients the effects of temporary vascular clipping (TC) (mean duration 16 minutes) were assessed. 2 patients subsequently declared infarction in the region of the probes. PBO2 fell from a mean 3.2 (95% CI 2.4-4.1) kPa to a minimum of 1.5 (95% CI 1.0-2.0) kPa in the non-infarct group. There was a lower baseline PBO2 (mean 0.8 kPa) in the patients who infarcted. PBCO2 mirrored PBO2 changes, whereas pHB did not change significantly in either group. Microdialysis changes associated with decreased PBO2 included a delayed increase in lactate, a raised lactate/pyruvate ratio and more rarely an increased glutamate. These changes were seen in 11 patients but were not predictive of infarction. Hypotension during aneurysm surgery is associated with a low PBO2. Multiparameter sensors can be sensitive to acute ischaemia. Microdialysis shows potential in the detection of metabolic changes during tissue hypoxia.

Evaluation of Machine Learning Algorithms for Classification of Primary Biological Aerosol using a new UV-LIF spectrometer

NASA Astrophysics Data System (ADS)

Ruske, S. T.; Topping, D. O.; Foot, V. E.; Kaye, P. H.; Stanley, W. R.; Morse, A. P.; Crawford, I.; Gallagher, M. W.

2016-12-01

Characterisation of bio-aerosols has important implications within Environment and Public Health sectors. Recent developments in Ultra-Violet Light Induced Fluorescence (UV-LIF) detectors such as the Wideband Integrated bio-aerosol Spectrometer (WIBS) and the newly introduced Multiparameter bio-aerosol Spectrometer (MBS) has allowed for the real time collection of fluorescence, size and morphology measurements for the purpose of discriminating between bacteria, fungal Spores and pollen. This new generation of instruments has enabled ever-larger data sets to be compiled with the aim of studying more complex environments, yet the algorithms used for specie classification remain largely invalidated. It is therefore imperative that we validate the performance of different algorithms that can be used for the task of classification, which is the focus of this study. For unsupervised learning we test Hierarchical Agglomerative Clustering with various different linkages. For supervised learning, ten methods were tested; including decision trees, ensemble methods: Random Forests, Gradient Boosting and AdaBoost; two implementations for support vector machines: libsvm and liblinear; Gaussian methods: Gaussian naïve Bayesian, quadratic and linear discriminant analysis and finally the k-nearest neighbours algorithm. The methods were applied to two different data sets measured using a new Multiparameter bio-aerosol Spectrometer. We find that clustering, in general, performs slightly worse than the supervised learning methods correctly classifying, at best, only 72.7 and 91.1 percent for the two data sets. For supervised learning the gradient boosting algorithm was found to be the most effective, on average correctly classifying 88.1 and 97.8 percent of the testing data respectively across the two data sets. We discuss the wider relevance of these results with regards to challenging existing classification in real-world environments.