Science.gov

Sample records for multiple microprocessor system

  1. Design of a Distributed Microprocessor Sensor System

    DTIC Science & Technology

    1990-04-01

    implemented through these methods, multiversion software and recovery the use of multiple identical software tasks running on blocks, are intended to... Multiversion software for real-time systems tolerant microprocessor that uses three processing is discussed by Shepherd32, Hitt33, Avizienis’, and...tasks and the there are no data available to determine the cost third is used for noncritical tasks. If a discrepancy effectiveness of multiversion

  2. Microprocessor controlled portable TLD system

    NASA Technical Reports Server (NTRS)

    Apathy, I.; Deme, S.; Feher, I.

    1996-01-01

    An up-to-date microprocessor controlled thermoluminescence dosemeter (TLD) system for environmental and space dose measurements has been developed. The earlier version of the portable TLD system, Pille, was successfully used on Soviet orbital stations as well as on the US Space Shuttle, and for environmental monitoring. The new portable TLD system, Pille'95, consists of a reader and TL bulb dosemeters, and each dosemeter is provided with an EEPROM chip for automatic identification. The glow curve data are digitised and analysed by the program of the reader. The measured data and the identification number appear on the LED display of the reader. Up to several thousand measured data together with the glow curves can be stored on a removable flash memory card. The whole system is supplied either from built-in rechargeable batteries or from the mains of the space station.

  3. Microprocessor-Controlled Laser Balancing System

    NASA Technical Reports Server (NTRS)

    Demuth, R. S.

    1985-01-01

    Material removed by laser action as part tested for balance. Directed by microprocessor, laser fires appropriate amount of pulses in correct locations to remove necessary amount of material. Operator and microprocessor software interact through video screen and keypad; no programing skills or unprompted system-control decisions required. System provides complete and accurate balancing in single load-and-spinup cycle.

  4. A Signal Processing Algorithm Based on Multiple Microprocessors for an Underwater Acoustic Imaging System.

    DTIC Science & Technology

    1980-12-01

    amp-C For the case of a narrow two degree beam width system that transmits a pulse at each bearing increment, the resulting image after the sector was...be a narrow beam system that scans the sector by transmitting a very short pulse at each bearing increment, provides linear inputs to memory from the...the range increments on the Indata array, for the bearing of the transmitted pulse, is indepen- dent of any of the other ranges. This is the summation

  5. Fidelity Optimization of Microprocessor System Simulations.

    DTIC Science & Technology

    1981-03-01

    I. TIT LE (end Su.btitle) 5 TYPE OF REPORT A PERIOD COVERED " Fidelity Optimization of Microprocessor THESIS /DgW&YON/ System Simulations...MICROPROCESSOR SYSTEM SIHULATIONS Earnest Taylor Landrum, Jr. A Thesis Submitted to the Graduate Faculty of Auburn University in Partial Fulfillment of the...Taylor Landrum, Jr. Permission is herewith granted to Auburn University to make copies of this thesis at its discretion, upon the request of

  6. Microprocessor-Based Laboratory Data Acquisition Systems.

    ERIC Educational Resources Information Center

    Woodard, F. E.; And Others

    1981-01-01

    Focuses on attributes of microcomputer systems which affect their usefulness in a laboratory environment. In addition to presenting general concepts, comments are made regarding the implementation of these concepts using a microprocessor-based data acquisition system developed at the University of North Carolina. (CO)

  7. A Microprocessor Architecture for Bibliographic Retrieval System.

    ERIC Educational Resources Information Center

    Martella, G.; Gobbi, G.

    1981-01-01

    Proposes a microprocessor-based architecture that makes large use of parallelism both in processing and in retrieval operations. The proposed system consists of three functional blocks: the query processor, simple query executers, and the answer composer. Twenty-one references are listed. (FM)

  8. A microprocessor controlled pressure scanning system

    NASA Technical Reports Server (NTRS)

    Anderson, R. C.

    1976-01-01

    A microprocessor-based controller and data logger for pressure scanning systems is described. The microcomputer positions and manages data from as many as four 48-port electro-mechanical pressure scanners. The maximum scanning rate is 80 pressure measurements per second (20 ports per second on each of four scanners). The system features on-line calibration, position-directed data storage, and once-per-scan display in engineering units of data from a selected port. The system is designed to be interfaced to a facility computer through a shared memory. System hardware and software are described. Factors affecting measurement error in this type of system are also discussed.

  9. Microprocessor-based cardiopulmonary monitoring system

    NASA Technical Reports Server (NTRS)

    1978-01-01

    The system uses a dedicated microprocessor for transducer control and data acquisition and analysis. No data will be stored in this system, but the data will be transmitted to the onboard data system. The data system will require approximately 12 inches of rack space and will consume only 100 watts of power. An experiment specific control panel, through a series of lighted buttons, will guide the operator through the test series providing a smaller margin of error. The experimental validity of the system was verified, and the reproducibility of data and reliability of the system checked. In addition, ease of training, ease of operator interaction, and crew acceptance were evaluated in actual flight conditions.

  10. Data transmission system with distributed microprocessors

    DOEpatents

    Nambu, Shigeo

    1985-01-01

    A data transmission system having a common request line and a special request line in addition to a transmission line. The special request line has priority over the common request line. A plurality of node stations are multi-drop connected to the transmission line. Among the node stations, a supervising station is connected to the special request line and takes precedence over other slave stations to become a master station. The master station collects data from the slave stations. The station connected to the common request line can assign a master control function to any station requesting to be assigned the master control function within a short period of time. Each station has an auto response control circuit. The master station automatically collects data by the auto response controlling circuit independently of the microprocessors of the slave stations.

  11. A Micro-Processor Based System as a Teaching Tool.

    ERIC Educational Resources Information Center

    Spero, Samuel W.

    1979-01-01

    Two instructional strategies incorporating a microprocessor-based computer system are described. These are the use of the system to drive a television monitor, and the system's use in generating problem sets. (MP)

  12. Modular, Microprocessor-Controlled Flash Lighting System

    NASA Technical Reports Server (NTRS)

    Kiefer, Dwayne; Gray, Elizabeth; Skupinski, Robert; Stachowicz, Arthur; Birchenough, William

    2006-01-01

    A microprocessor-controlled lighting system generates brief, precisely timed, high-intensity flashes of light for scientific imaging at frame rates up to about 1 kHz. The system includes an array of light-emitting diodes (LEDs) that are driven in synchronism with an externally generated timing signal (for example, a timing signal generated by a video camera). The light output can be varied in peak intensity, pulse duration, pulse delay, and pulse rate, all depending on the timing signal and associated externally generated control signals. The array of LEDs comprises as many as 16 LED panels that can be attached together. Each LED panel is a module consisting of a rectangular subarray of 10 by 20 LEDs of advanced design on a printed-circuit board in a mounting frame with a power/control connector. The LED panels are controlled by an LED control module that contains an AC-to-DC power supply, a control board, and 8 LED-panel driver boards. In prior LED panels, the LEDs are packaged at less than maximum areal densities in bulky metal housings that reduce effective active areas. In contrast, in the present LED panels, the LEDs are packed at maximum areal density so as to afford 100-percent active area and so that when panels are joined side by side to form the array, there are no visible seams between them and the proportion of active area is still 100 percent. Each panel produces an illuminance of .5 x 10( exp 4) lux at a distance of 5.8 in. (approx.1.6 cm). The LEDs are driven according to a pulse-width-modulation control scheme that makes it safe to drive the LEDs beyond their rated steady-state currents in order to generate additional light during short periods. The drive current and the pulse-width modulation for each LED panel can be controlled independently of those of the other 15 panels. The maximum allowable duration of each pulse of drive current is a function of the amount of overdrive, the total time to be spent in overdrive operation, and the limitations

  13. Microprocessors in Systems Engineering at the U.S. Naval Academy.

    ERIC Educational Resources Information Center

    Mitchell, Eugene E., Ed.; Lowe, W. M., Ed.

    1982-01-01

    Describes the introduction of microprocessors into the Weapons and Systems Engineering Department at the U.S. Naval Academy, including planning decisions, implementation, procedures, uses of microprocessors in the department, and impact on the Systems Engineering major and curriculum. (SK)

  14. Autofocusing system based on signal processing of single chip microprocessor

    NASA Astrophysics Data System (ADS)

    Xu, Xiangdong; Zeng, Chao; Li, Feng; Huang, GuiZao

    2002-09-01

    In this paper, an auto-focusing system based on Signal Processing of Single-chip Microprocessor is introduced to realize auto-focusing. The system can automatically get the distance information of the worktable and drive the step motor to reach the aim of auto-focusing. The auto-focusing system is loaded in the original CMOS-based measuring system. After the AV signals from CMOS image sensor pass through the analog filter, the single-chip microprocessor samples and processes them, then controls the lens to be in focus. As a result, this method can not only achieve all functions of focusing, but also avoid complicated calculations. The system is low power consuming, programming rapidly. Here we analyse the key technique of the system and the results of the experiments are given. It can be practical applied and the further perfection of algorithm and software will result in the system having more function.

  15. Real-time fetal ECG system design using embedded microprocessors

    NASA Astrophysics Data System (ADS)

    Meyer-Baese, Uwe; Muddu, Harikrishna; Schinhaerl, Sebastian; Kumm, Martin; Zipf, Peter

    2016-05-01

    The emphasis of this project lies in the development and evaluation of new robust and high fidelity fetal electrocardiogram (FECG) systems to determine the fetal heart rate (FHR). Recently several powerful algorithms have been suggested to improve the FECG fidelity. Until now it is unknown if these algorithms allow a real-time processing, can be used in mobile systems (low power), and which algorithm produces the best error rate for a given system configuration. In this work we have developed high performance, low power microprocessor-based biomedical systems that allow a fair comparison of proposed, state-of-the-art FECG algorithms. We will evaluate different soft-core microprocessors and compare these solutions to other commercial off-the-shelf (COTS) hardcore solutions in terms of price, size, power, and speed.

  16. Human supervision and microprocessor control of an optical tracking system

    NASA Technical Reports Server (NTRS)

    Bigley, W. J.; Vandenberg, J. D.

    1981-01-01

    Gunners using small calibre anti-aircraft systems have not been able to track high-speed air targets effectively. Substantial improvement in the accuracy of surface fire against attacking aircraft has been realized through the design of a director-type weapon control system. This system concept frees the gunner to exercise a supervisory/monitoring role while the computer takes over continuous target tracking. This change capitalizes on a key consideration of human factors engineering while increasing system accuracy. The advanced system design, which uses distributed microprocessor control, is discussed at the block diagram level and is contrasted with the previous implementation.

  17. Microprocessor control for standardized power control systems

    NASA Technical Reports Server (NTRS)

    Green, D. G.; Perry, E.

    1978-01-01

    The use of microcomputers in space-oriented power systems as a replacement for existing inflexible analog type controllers has been proposed. This study examines multiprocessor systems, various modularity concepts and presents a conceptualized power system incorporating a multiprocessor controller as well as preliminary results from a breadboard model of the proposed system.

  18. Feasibility study of a microprocessor based oculometer system

    NASA Technical Reports Server (NTRS)

    Varanasi, M. R.

    1981-01-01

    The elimination of redundancy in data to maximize processing speed and minimize storage requirements were objectives in a feasibility study of a microprocessor based oculometer system that would be portable in size and flexible in use. The appropriate architectural design of the signal processor, improved optics, and the reduction of size, weight, and power to the system were investigated. A flow chart is presented showing the strategy of the design. The simulation for developing microroutines for the high speed algorithmic processor subsystem is discussed as well as the Karhunen-Loeve transform technique for data compression.

  19. Microprocessor controlled optical measuring system for large mirror modules

    NASA Astrophysics Data System (ADS)

    Koehne, R.; Rach, E.; Reich, F.

    1985-10-01

    A microprocessor controlled contactless measuring system was developed in order to determine how the beam quality of mirrors influences the performance of solar plants with focusing collectors. The system was installed to investigate large flat and curved mirror surfaces ( or = 10 sq m). An algorithm to evaluate the measured data was derived. The very accurate method is based on laser ray tracing to determine the ripple and the deviations from the ideal contour which can be expressed as a root mean square value. Measurements on parabolic trough mirrors and heliostat segments yield rms values of 10 and 3.7 mrad, respectively.

  20. USAFSAM Microprocessor Audiometer: System Reference Manual

    DTIC Science & Technology

    1980-04-01

    As indicated in Figure 2, the microcomputer consists of the following Intel multibus compatible boards: SBC 80/20 single - board computer , SBC 104...Womble. WIZARD programmer manual. SAM-TR-79-15, Sep 1979. 5. Intel Corporation. SBC 80/20 single board computer hardware reference manual. Document No... board computer (51 provides the "brains" of the system, along with additional memory and 1/0 capability. In fact, the analog audiometer is controlled

  1. A Low Cost Navigation Microprocessor System.

    DTIC Science & Technology

    1977-03-01

    a., 77843. uaed to iteratively update hi ~~~~~~~~~ -~~~- .:S~~~~~~~~~~~~~ . .— a — ~~~~~~~~~. - ~~~~ - . .- . — --- •5 n- -pr~~~ I~~~ ‘77 PIC ~~DU...the altitude above the reference ellipsoid (Ian — feature is implemented as step (6) below . nude —longitude—altitude coordinate system). Since cal

  2. Security policy concepts for microprocessor-based systems

    SciTech Connect

    Axline, R.M. Jr.; Ormesher, R.C.

    1989-03-01

    This report presents security policies for microprocessor-based systems and gives an example of how to enforce these policies, using an independent, hardware-based monitor, in a hypothetical single-processor system. The purpose of these policies is to detect erroneous behavior of the microprocessor system and to guarantee that accesses (read, write, or execute), by executable procedures,to the various system resources (other procedure, data areas, and peripheral ports) are in accordance with rules that are defined precisely and completely. We present the main result of our research as a ''Second-Order Security Policy'', which describes a segmentation of system resources into a number of ''Blocks'' and defines access rights of each ''Process Block'' to all Blocks in the system. The hardware-monitor example is a conceptual design of an independent monitor that we believe can be built to enforce the second-order policy in real time. This approach will be effective in preventing erroneous accesses to data structures and peripherals and in detecting errors in the transfer of program control from Block to Block. 9 refs., 11 figs., 3 tabs.

  3. Microprocessor tester for the treat upgrade reactor trip system

    SciTech Connect

    Lenkszus, F.R.; Bucher, R.G.

    1984-01-01

    The upgrading of the Transient Reactor Test (TREAT) Facility at ANL-Idaho has been designed to provide additional experimental capabilities for the study of core disruptive accident (CDA) phenomena. In addition, a programmable Automated Reactor Control System (ARCS) will permit high-power transients up to 11,000 MW having a controlled reactor period of from 15 to 0.1 sec. These modifications to the core neutronics will improve simulation of LMFBR accident conditions. Finally, a sophisticated, multiply-redundant safety system, the Reactor Trip System (RTS), will provide safe operation for both steady state and transient production operating modes. To insure that this complex safety system is functioning properly, a Dedicated Microprocessor Tester (DMT) has been implemented to perform a thorough checkout of the RTS prior to all TREAT operations.

  4. Microprocessor-based control of the photovoltaic solar power system for an AM radio station

    SciTech Connect

    Much, C. H.; Rothenheber, P. J.

    1980-01-01

    A microprocessor-based controller for a 15 kW photovoltaic power system powering an AM radio station keeps dc bus voltage between desired limits, governs battery operation, monitors safety conditions, and provides status reporting. The microprocessor also facilitates complicated algorithms that improve performance. The first three months of system operation are presented.

  5. An Interdisciplinary Microprocessor Project.

    ERIC Educational Resources Information Center

    Wilcox, Alan D.; And Others

    1985-01-01

    Describes an unusual project in which third-year computer science students designed and built a four-bit multiplier circuit and then combines it with software to complete a full 16-bit multiplication. The multiplier was built using TTL components, interfaced with a Z-80 microprocessor system, and programed in assembly language. (JN)

  6. Microprocessor systems for self-control of vital bodily functions.

    PubMed

    Yumatov, E A

    2000-01-01

    This article presents a fundamentally novel approach to an urgent medico-social problem of providing the timely medical care. To maintain people's health and life in their everyday activities, a new concept of the medical instrument-making industry was put forward. This concept was developed in terms of the theory of functional systems, which revealed the universal rules of self-regulation of bodily functions. The practical realization of the above-mentioned concept involved the construction, patenting, and production of a number of original devices capable of warning the patient about disorders in basic bodily functions. These devices included a Heart Protection System, a Stress Doser, a Physiological Clock, a Ration Controller, and a Mother-Fetus Controller. They can all be regarded as informational household microprocessor-based instruments of the 21st century.

  7. The role of the microprocessor in onboard image processing for the information adaptive system

    NASA Technical Reports Server (NTRS)

    Kelly, W. L., IV; Meredith, B. D.

    1980-01-01

    The preliminary design of the Information Adaptive System is presented. The role of the microprocessor in the implementation of the individual processing elements is discussed. Particular emphasis is placed on multispectral image data processing.

  8. Orbit determination software development for microprocessor based systems: Evaluation and recommendations

    NASA Technical Reports Server (NTRS)

    Shenitz, C. M.; Mcgarry, F. E.; Tasaki, K. K.

    1980-01-01

    A guide is presented for National Aeronautics and Space Administration management personnel who stand to benefit from the lessons learned in developing microprocessor-based flight dynamics software systems. The essential functional characteristics of microprocessors are presented. The relevant areas of system support software are examined, as are the distinguishing characteristics of flight dynamics software. Design examples are provided to illustrate the major points presented, and actual development experience obtained in this area is provided as evidence to support the conclusions reached.

  9. Information distribution in distributed microprocessor based flight control systems

    NASA Technical Reports Server (NTRS)

    Montgomery, R. C.; Lee, P. S.

    1977-01-01

    This paper presents an optimal control theory that accounts for variable time intervals in the information distribution to control effectors in a distributed microprocessor based flight control system. The theory is developed using a linear process model for the aircraft dynamics and the information distribution process is modeled as a variable time increment process where, at the time that information is supplied to the control effectors, the control effectors know the time of the next information update only in a stochastic sense. An optimal control problem is formulated and solved that provides the control law that minimizes the expected value of a quadratic cost function. An example is presented where the theory is applied to the control of the longitudinal motions of the F8-DFBW aircraft. Theoretical and simulation results indicate that, for the example problem, the optimal cost obtained using a variable time increment Markov information update process where the control effectors know only the past information update intervals and the Markov transition mechanism is almost identical to that obtained using a known uniform information update interval.

  10. Experimental APL system based on a multi-microprocessor architecture

    SciTech Connect

    Sakellardis, U.

    1983-01-01

    After an introduction dealing with the fundamental aspects and main extensions of APL, a programming language based on array operations, the author describes an experimental language, APL 90, which can take advantage of multi-microprocessor architecture to overcome many limitations of standard APL. 5 references.

  11. Loran-C digital word generator for use with a KIM-1 microprocessor system

    NASA Technical Reports Server (NTRS)

    Nickum, J. D.

    1977-01-01

    The problem of translating the time of occurrence of received Loran-C pulses into a time, referenced to a particular period of occurrence is addressed and applied to the design of a digital word generator for a Loran-C sensor processor package. The digital information from this word generator is processed in a KIM-1 microprocessor system which is based on the MOS 6502 CPU. This final system will consist of a complete time difference sensor processor for determining position information using Loran-C charts. The system consists of the KIM-1 microprocessor module, a 4K RAM memory board, a user interface, and the Loran-C word generator.

  12. Self-Checking Pairs Of Microprocessors

    NASA Technical Reports Server (NTRS)

    Smith, Brian S.

    1995-01-01

    Method of imparting fault tolerance to computer system provides for immediate detection of faults at microprocessor level. Shadow microprocessor provides nominal duplicate outputs to verify functioning of main microprocessor. When output signal on any pin of one microprocessor differs from that on corresponding pin of other microprocessor, comparator puts out alarm signal.

  13. Investigating the Possibility of a Microprocessor-Based Machine Translation System,

    DTIC Science & Technology

    terminological polysemy and syntactic complexity are reduced via the notions of controlled vocabulary and restricted syntax. Given these constraints, it...feasibility of Machine Translation (MT) in a microprocessor environment. These incorporates as far as possible features of large-scale MT systems that

  14. Development of a microprocessor-based Sun-tracking system for solar collectors

    NASA Astrophysics Data System (ADS)

    Kohler, S. M.; Wilcoxen, J. L.

    1980-04-01

    The development of a prototype Sun-tracking system and the tests performed on it on an east-west trough solar collector array are described. The system includes a controller built around an RCA1802 microprocessor, a digital shaft encoder, and a heat flux sensor. The heat flux sensor consists of a fine resistance wire wrapped around the receiver tube. The wire is used to correct errors in calculated tracking angles arising from reflector imperfections and misalignments.

  15. Advanced Transport Operating System (ATOPS) color displays software description microprocessor system

    NASA Technical Reports Server (NTRS)

    Slominski, Christopher J.; Plyler, Valerie E.; Dickson, Richard W.

    1992-01-01

    This document describes the software created for the Sperry Microprocessor Color Display System used for the Advanced Transport Operating Systems (ATOPS) project on the Transport Systems Research Vehicle (TSRV). The software delivery known as the 'baseline display system', is the one described in this document. Throughout this publication, module descriptions are presented in a standardized format which contains module purpose, calling sequence, detailed description, and global references. The global reference section includes procedures and common variables referenced by a particular module. The system described supports the Research Flight Deck (RFD) of the TSRV. The RFD contains eight cathode ray tubes (CRTs) which depict a Primary Flight Display, Navigation Display, System Warning Display, Takeoff Performance Monitoring System Display, and Engine Display.

  16. A microprocessor-based position control system for a telescope secondary mirror

    NASA Technical Reports Server (NTRS)

    Lorell, K. R.; Barrows, W. F.; Clappier, R. R.; Lee, G. K.

    1983-01-01

    The pointing requirements for the Shuttle IR Telescope Facility (SIRTF), which consists of an 0.85-m cryogenically cooled IR telescope, call for an image stability of 0.25 arcsec. Attention is presently given to a microprocessor-based position control system developed for the control of the SIRTF secondary mirror, employing a special control law (to minimize energy dissipation), a precision capacitive position sensor, and a specially designed power amplifier/actuator combination. The microprocessor generates the command angular position and rate waveforms in order to maintain a 90 percent dwell time/10 percent transition time ratio independently of chop frequency or amplitude. Performance and test results of a prototype system designed for use with a demonstration model of the SIRTF focal plane fine guidance sensor are presented.

  17. Non Radiation Hardened Microprocessors in Spaced Based Remote Sensing Systems

    NASA Technical Reports Server (NTRS)

    Decoursey, Robert J.; Estes, Robert F.; Melton, Ryan

    2006-01-01

    The CALIPSO (Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observations) mission is a comprehensive suite of active and passive sensors including a 20Hz 230mj Nd:YAG lidar, a visible wavelength Earth-looking camera and an imaging infrared radiometer. CALIPSO flies in formation with the Earth Observing System Post-Meridian (EOS PM) train, provides continuous, near-simultaneous measurements and is a planned 3 year mission. CALIPSO was launched into a 98 degree sun synchronous Earth orbit in April of 2006 to study clouds and aerosols and acquires over 5 gigabytes of data every 24 hours. The ground track of one CALIPSO orbit as well as high and low intensity South Atlantic Anomaly outlines is shown. CALIPSO passes through the SAA several times each day. Spaced based remote sensing systems that include multiple instruments and/or instruments such as lidar generate large volumes of data and require robust real-time hardware and software mechanisms and high throughput processors. Due to onboard storage restrictions and telemetry downlink limitations these systems must pre-process and reduce the data before sending it to the ground. This onboard processing and realtime requirement load may mean that newer more powerful processors are needed even though acceptable radiation-hardened versions have not yet been released. CALIPSO's single board computer payload controller processor is actually a set of four (4) voting non-radiation hardened COTS Power PC 603r's built on a single width VME card by General Dynamics Advanced Information Systems (GDAIS). Significant radiation concerns for CALIPSO and other Low Earth Orbit (LEO) satellites include the South Atlantic Anomaly (SAA), the north and south poles and strong solar events. Over much of South America and extending into the South Atlantic Ocean the Van Allen radiation belts dip to just 200-800km and spacecraft entering this area are subjected to high energy protons and experience higher than normal Single Event Upset

  18. A Microprocessor Based CAI System with Graphic Capabilities.

    ERIC Educational Resources Information Center

    Mabry, Frank J.; And Others

    This paper describes a system which operates on an independent basis as well as connected to communications network, e.g., PLATO and ASCII based communication systems. The system also has facilities for local production and use of PILOT lessons, for support of a generalized programming language (NSBASIC), and for development of graphic sequences.…

  19. Airborne Systems Software Acquisition Engineering Guidebook for Microprocessors and Firmware.

    DTIC Science & Technology

    1980-02-01

    cycle of your system? The cost to your system of loss of mass production support for your devices may be great . * Field support - Especially important if...specification - source of potential devide type proliferation. 0 Environment - devices must be evaluated and slash sheets published. 0 Economics - itis

  20. A distributed microprocessor system for spacecraft control and data handling

    NASA Technical Reports Server (NTRS)

    Rennels, D. A.

    1977-01-01

    The specific requirements for spacecraft computing systems are considered. These requirements are partly related to the constraints of limited resources of power, weight, and volume. Another important factor is the requirement of extremely high reliability. These reliability requirements have led to introduction of automated redundancy techniques on board the spacecraft. The various redundant computers check each other and provide recovery procedures when a computer is found to have failed. Past and future capabilities are considered along with distributed processing requirements. System considerations are discussed, taking into account suboptimum computer throughput, sensitivity to software modifications, hierarchic timing, I/O granularity, restricted communications, synchronous functions, hierarchic control, and concurrent error detection. A description is presented of the Unified Data System (UDS), which consists of a set of standard microcomputers connected by several buses. Attention is also given to synchronization and timing, the executive control structure, the programming language, and the executive program.

  1. Microprocessor control system for 200-kilowatt Mod-OA wind turbines

    NASA Technical Reports Server (NTRS)

    Nyland, T. W.; Birchenough, A. G.

    1982-01-01

    The microprocessor system and program used to control the operation of the 200-kW Mod-OA wind turbines is described. The system is programmed to begin startup and shutdown sequences automatically and to control yaw motion. Rotor speed and power output are controlled with integral and proportional control of the blade pitch angle. Included in the report are a description of the hardware and a discussion of the software programming technique. A listing of the PL/M software program is given.

  2. Development of a microprocessor controller for stand-alone photovoltaic power systems

    NASA Astrophysics Data System (ADS)

    Millner, A. R.; Kaufman, D. L.

    1984-06-01

    A controller for stand-alone photovoltaic systems has been developed using a low power CMOS microprocessor. It performs battery state of charge estimation, array control, load management, instrumentation, automatic testing, and communications functions. Array control options are sequential subarray switching and maximum power control. A calculator keypad and LCD display provides manual control, fault diagnosis and digital multimeter functions. An RS-232 port provides data logging or remote control capability. A prototype 5 kW unit has been built and tested successfully. The controller is expected to be useful in village photovoltaic power systems, large solar water pumping installations, and other battery management applications.

  3. Development of a microprocessor controller for stand-alone photovoltaic power systems

    NASA Technical Reports Server (NTRS)

    Millner, A. R.; Kaufman, D. L.

    1984-01-01

    A controller for stand-alone photovoltaic systems has been developed using a low power CMOS microprocessor. It performs battery state of charge estimation, array control, load management, instrumentation, automatic testing, and communications functions. Array control options are sequential subarray switching and maximum power control. A calculator keypad and LCD display provides manual control, fault diagnosis and digital multimeter functions. An RS-232 port provides data logging or remote control capability. A prototype 5 kW unit has been built and tested successfully. The controller is expected to be useful in village photovoltaic power systems, large solar water pumping installations, and other battery management applications.

  4. Development of a fault-tolerant microprocessor based computer system for space flight

    NASA Technical Reports Server (NTRS)

    Montgomery, V. T.

    1981-01-01

    A methodology for the design of a tightly coupled, highly reliable microprocessor based computer system is described. The concept of triple modular redundancy with sparing is used. The notion of synchronizing by using a single crystal oscillator is examined. The use of decoders to replace voters is also used. The decoders not only isolate the failed module but also allow error identification to be accomplished. Each module is to have its own RAM memory. The necessary circuitry to select a correct memory and the corresponding DMA controller was designed.

  5. Microprocessor-based interface for oceanography

    NASA Technical Reports Server (NTRS)

    Hansen, G. R.

    1979-01-01

    Ocean floor imaging system incorporates five identical microprocessor-based interface units each assigned to specific sonar instrument to simplify system. Central control module based on same microprocessor eliminates need for custom tailoring hardware interfaces for each instrument.

  6. Pain and efficacy rating of a microprocessor-controlled metered injection system for local anaesthesia in minor hand surgery.

    PubMed

    Nimigan, André S; Gan, Bing Siang

    2011-01-01

    Purpose. Little attention has been given to syringe design and local anaesthetic administration methods. A microprocessor-controlled anaesthetic delivery device has become available that may minimize discomfort during injection. The purpose of this study was to document the pain experience associated with the use of this system and to compare it with use of a conventional syringe. Methods. A prospective, randomized clinical trial was designed. 40 patients undergoing carpal tunnel release were block randomized according to sex into a two groups: a traditional syringe group and a microprocessor-controlled device group. The primary outcome measure was surgical pain and local anaesthetic administration pain. Secondary outcomes included volume of anaesthetic used and injection time. Results. Analysis showed that equivalent anaesthesia was achieved in the microprocessor-controlled group despite using a significantly lower volume of local anaesthetic (P = .0002). This same group, however, has significantly longer injection times (P < .0001). Pain during the injection process or during surgery was not different between the two groups. Conclusions. This RCT comparing traditional and microprocessor controlled methods of administering local anaesthetic showed similar levels of discomfort in both groups. While the microprocessor-controlled group used less volume, the total time for the administration was significantly greater.

  7. System and method for leveraging human physiological traits to control microprocessor frequency

    SciTech Connect

    Shye, Alex; Pan, Yan; Scholbrock, Benjamin; Miller, J. Scott; Memik, Gokhan; Dinda, Peter A; Dick, Robert P

    2014-03-25

    A system and method for leveraging physiological traits to control microprocessor frequency are disclosed. In some embodiments, the system and method may optimize, for example, a particular processor-based architecture based on, for example, end user satisfaction. In some embodiments, the system and method may determine, for example, whether their users are satisfied to provide higher efficiency, improved reliability, reduced power consumption, increased security, and a better user experience. The system and method may use, for example, biometric input devices to provide information about a user's physiological traits to a computer system. Biometric input devices may include, for example, one or more of the following: an eye tracker, a galvanic skin response sensor, and/or a force sensor.

  8. Briefing: Microprocessors.

    ERIC Educational Resources Information Center

    Standing, Roy A.

    1982-01-01

    Reviews the basic concepts and technology behind the functions computers perform, describes the miniaturization of computer components, discusses the development of the microprocessor and the microcomputer, and makes projections concerning the future of the microcomputer market. Information is provided on the features, costs, and manufacturers of…

  9. Microprocessor control of a wind turbine generator

    NASA Technical Reports Server (NTRS)

    Gnecco, A. J.; Whitehead, G. T.

    1978-01-01

    A microprocessor based system was used to control the unattended operation of a wind turbine generator. The turbine and its microcomputer system are fully described with special emphasis on the wide variety of tasks performed by the microprocessor for the safe and efficient operation of the turbine. The flexibility, cost and reliability of the microprocessor were major factors in its selection.

  10. The Stand-Alone Microprocessor System: A Valuable Tool in College Admissions and Recruitment.

    ERIC Educational Resources Information Center

    Garrett, Larry Neal

    1983-01-01

    The stand-alone microprocessor is seen as one innovative tool that can be used both in the organizational management of decline and in meeting specific organizational needs such as those of the admissions director and staff. The term "microprocessor" is defined. (MLW)

  11. Microprocessor user support at Langley Research Center

    NASA Technical Reports Server (NTRS)

    Tucker, J. H.

    1980-01-01

    The use of microprocessors pose significant problems including: (1) a long learning process for proficient use of microprocessors; (2) the requirement for extensive support in both hardware and software; and (3) the need for coordination and sharing of the creative effort to avoid unnecessary duplication. To address these problems, Langley Research Center has established a microprocessor users committee to provide an advisory interface for management and users, and is training microprocessor users. A newsletter is published to disseminate information among microprocessor users. Both cross software on the central computer complex and microprocessor development systems are used to support the design of microprocessor based systems. Each of these activities is reviewed with special emphasis given to the microprocessor support available from the central computer complex. The effectiveness of the approach being taken at Langley is assessed and specific hardware and software development efforts that are targeted toward enhancing the existing microprocessing support are discussed.

  12. [An integral chip for the multiphase pulse-duration modulation used for voltage changer in biomedical microprocessor systems].

    PubMed

    Balashov, A M; Selishchev, S V

    2004-01-01

    An integral chip (IC) was designed for controlling the step-down pulse voltage converter, which is based on the multiphase pulse-duration modulation, for use in biomedical microprocessor systems. The CMOS technology was an optimal basis for the IC designing. An additional feedback circuit diminishes the output voltage dispersion at dynamically changing loads.

  13. A microprocessor based anti-aliasing filter for a PCM system

    NASA Technical Reports Server (NTRS)

    Morrow, D. C.; Sandlin, D. R.

    1984-01-01

    Described is the design and evaluation of a microprocessor based digital filter. The filter was made to investigate the feasibility of a digital replacement for the analog pre-sampling filters used in telemetry systems at the NASA Ames-Dryden Flight Research Facility (DFRF). The digital filter will utilize an Intel 2920 Analog Signal Processor (ASP) chip. Testing includes measurements of: (1) the filter frequency response and, (2) the filter signal resolution. The evaluation of the digital filter was made on the basis of circuit size, projected environmental stability and filter resolution. The 2920 based digital filter was found to meet or exceed the pre-sampling filter specifications for limited signal resolution applications.

  14. Development of a microprocessor controller for stand-alone photovoltaic power systems

    SciTech Connect

    Millner, A.R.; Kaufman, D.L.

    1984-06-01

    As the cost of photovoltaic modules decreases, system control and related engineering costs become very important. To meet this need for flexibility with a minimum of customizing cost, and yet consume only a few watts of power is within the capabilities of today's microprocessor. The first unit was produced under DOE contract DEN3-310 and tested for NASA at TriSolarCorp. It is 5kW maximum power controlling battery charger which can also be configured as a 5kW batteryless motor drive. The entire controller interfaces with existing 500 watt MPC power modules, operates in a NEMA-4 enclosuer over an ambient temperature range of -25/sup 0/C to /sup +/45/sup 0/C, operates from either a 12V battery or a 40V to 300V dc unregulated solar array or battery bus. The unit design and cost are discussed, and testing is reported.

  15. MICROPROCESSOR-BASED DATA-ACQUISITION SYSTEM FOR A BOREHOLE RADAR.

    USGS Publications Warehouse

    Bradley, Jerry A.; Wright, David L.

    1987-01-01

    An efficient microprocessor-based system is described that permits real-time acquisition, stacking, and digital recording of data generated by a borehole radar system. Although the system digitizes, stacks, and records independently of a computer, it is interfaced to a desktop computer for program control over system parameters such as sampling interval, number of samples, number of times the data are stacked prior to recording on nine-track tape, and for graphics display of the digitized data. The data can be transferred to the desktop computer during recording, or it can be played back from a tape at a latter time. Using the desktop computer, the operator observes results while recording data and generates hard-copy graphics in the field. Thus, the radar operator can immediately evaluate the quality of data being obtained, modify system parameters, study the radar logs before leaving the field, and rerun borehole logs if necessary. The system has proven to be reliable in the field and has increased productivity both in the field and in the laboratory.

  16. Development of a patch type embedded cardiac function monitoring system using dual microprocessor for arrhythmia detection in heart disease patient.

    PubMed

    Jang, Yongwon; Noh, Hyung Wook; Lee, I B; Jung, Ji-Wook; Song, Yoonseon; Lee, Sooyeul; Kim, Seunghwan

    2012-01-01

    A patch type embedded cardiac function monitoring system was developed to detect arrhythmias such as PVC (Premature Ventricular Contraction), pause, ventricular fibrillation, and tachy/bradycardia. The overall system is composed of a main module including a dual processor and a Bluetooth telecommunication module. The dual microprocessor strategy minimizes power consumption and size, and guarantees the resources of embedded software programs. The developed software was verified with standard DB, and showed good performance.

  17. EFFECTS OF THE GENIUM MICROPROCESSOR KNEE SYSTEM ON KNEE MOMENT SYMMETRY DURING HILL WALKING

    PubMed Central

    Highsmith, M. Jason; Klenow, Tyler D.; Kahle, Jason T.; Wernke, Matthew M.; Carey, Stephanie L.; Miro, Rebecca M.; Lura, Derek J.

    2016-01-01

    Use of the Genium microprocessor knee (MPK) system reportedly improves knee kinematics during walking and other functional tasks compared to other MPK systems. This improved kinematic pattern was observed when walking on different hill conditions and at different speeds. Given the improved kinematics associated with hill walking while using the Genium, a similar improvement in the symmetry of knee kinetics is also feasible. The purpose of this study was to determine if Genium MPK use would reduce the degree of asymmetry (DoA) of peak stance knee flexion moment compared to the C-Leg MPK in transfemoral amputation (TFA) patients. This study used a randomized experimental crossover of TFA patients using Genium and C-Leg MPKs (n = 20). Biomechanical gait analysis by 3D motion tracking with floor mounted force plates of TFA patients ambulating at different speeds on 5° ramps was completed. Knee moment DoA was significantly different between MPK conditions in the slow and fast uphill as well as the slow and self-selected downhill conditions. In a sample of high-functioning TFA patients, Genium knee system accommodation and use improved knee moment symmetry in slow speed walking up and down a five degree ramp compared with C-Leg. Additionally, the Genium improved knee moment symmetry when walking downhill at comfortable speed. These results likely have application in other patients who could benefit from more consistent knee function, such as older patients and others who have slower walking speeds. PMID:28066523

  18. EFFECTS OF THE GENIUM MICROPROCESSOR KNEE SYSTEM ON KNEE MOMENT SYMMETRY DURING HILL WALKING.

    PubMed

    Highsmith, M Jason; Klenow, Tyler D; Kahle, Jason T; Wernke, Matthew M; Carey, Stephanie L; Miro, Rebecca M; Lura, Derek J

    2016-09-01

    Use of the Genium microprocessor knee (MPK) system reportedly improves knee kinematics during walking and other functional tasks compared to other MPK systems. This improved kinematic pattern was observed when walking on different hill conditions and at different speeds. Given the improved kinematics associated with hill walking while using the Genium, a similar improvement in the symmetry of knee kinetics is also feasible. The purpose of this study was to determine if Genium MPK use would reduce the degree of asymmetry (DoA) of peak stance knee flexion moment compared to the C-Leg MPK in transfemoral amputation (TFA) patients. This study used a randomized experimental crossover of TFA patients using Genium and C-Leg MPKs (n = 20). Biomechanical gait analysis by 3D motion tracking with floor mounted force plates of TFA patients ambulating at different speeds on 5° ramps was completed. Knee moment DoA was significantly different between MPK conditions in the slow and fast uphill as well as the slow and self-selected downhill conditions. In a sample of high-functioning TFA patients, Genium knee system accommodation and use improved knee moment symmetry in slow speed walking up and down a five degree ramp compared with C-Leg. Additionally, the Genium improved knee moment symmetry when walking downhill at comfortable speed. These results likely have application in other patients who could benefit from more consistent knee function, such as older patients and others who have slower walking speeds.

  19. Microfluidic pneumatic logic circuits and digital pneumatic microprocessors for integrated microfluidic systems.

    PubMed

    Rhee, Minsoung; Burns, Mark A

    2009-11-07

    We have developed pneumatic logic circuits and microprocessors built with microfluidic channels and valves in polydimethylsiloxane (PDMS). The pneumatic logic circuits perform various combinational and sequential logic calculations with binary pneumatic signals (atmosphere and vacuum), producing cascadable outputs based on Boolean operations. A complex microprocessor is constructed from combinations of various logic circuits and receives pneumatically encoded serial commands at a single input line. The device then decodes the temporal command sequence by spatial parallelization, computes necessary logic calculations between parallelized command bits, stores command information for signal transportation and maintenance, and finally executes the command for the target devices. Thus, such pneumatic microprocessors will function as a universal on-chip control platform to perform complex parallel operations for large-scale integrated microfluidic devices. To demonstrate the working principles, we have built 2-bit, 3-bit, 4-bit, and 8-bit microprocessors to control various target devices for applications such as four color dye mixing, and multiplexed channel fluidic control. By significantly reducing the need for external controllers, the digital pneumatic microprocessor can be used as a universal on-chip platform to autonomously manipulate microfluids in a high throughput manner.

  20. Mark IVA microprocessor support

    NASA Technical Reports Server (NTRS)

    Burford, A. L.

    1982-01-01

    The requirements and plans for the maintenance support of microprocessor-based controllers in the Deep Space Network Mark IVA System are discussed. Additional new interfaces and 16-bit processors have introduced problems not present in the Mark III System. The need for continuous training of maintenance personnel to maintain a level of expertise consistent with the sophistication of the required tools is also emphasized.

  1. Analysis of the Intel 386 and i486 microprocessors for the Space Station Freedom Data Management System

    NASA Technical Reports Server (NTRS)

    Liu, Yuan-Kwei

    1991-01-01

    The feasibility is analyzed of upgrading the Intel 386 microprocessor, which has been proposed as the baseline processor for the Space Station Freedom (SSF) Data Management System (DMS), to the more advanced i486 microprocessors. The items compared between the two processors include the instruction set architecture, power consumption, the MIL-STD-883C Class S (Space) qualification schedule, and performance. The advantages of the i486 over the 386 are (1) lower power consumption; and (2) higher floating point performance. The i486 on-chip cache does not have parity check or error detection and correction circuitry. The i486 with on-chip cache disabled, however, has lower integer performance than the 386 without cache, which is the current DMS design choice. Adding cache to the 386/386 DX memory hierachy appears to be the most beneficial change to the current DMS design at this time.

  2. Analysis of the Intel 386 and i486 microprocessors for the Space Station Freedom Data Management System

    NASA Technical Reports Server (NTRS)

    Liu, Yuan-Kwei

    1991-01-01

    The feasibility is analyzed of upgrading the Intel 386 microprocessor, which has been proposed as the baseline processor for the Space Station Freedom (SSF) Data Management System (DMS), to the more advanced i486 microprocessors. The items compared between the two processors include the instruction set architecture, power consumption, the MIL-STD-883C Class S (Space) qualification schedule, and performance. The advantages of the i486 over the 386 are (1) lower power consumption; and (2) higher floating point performance. The i486 on-chip cache does not have parity check or error detection and correction circuitry. The i486 with on-chip cache disabled, however, has lower integer performance than the 386 without cache, which is the current DMS design choice. Adding cache to the 386/387 DX memory hierarchy appears to be the most beneficial change to the current DMS design at this time.

  3. Devices and systems-on-chip for photonic communication links in a microprocessor

    NASA Astrophysics Data System (ADS)

    Wade, Mark T.

    For the first time, high-performance photonic devices and electronic-photonic systems-on-chip are monolithically integrated in an advanced CMOS microelectronics fabrication process. This includes a silicon optical resonator termed the "spoked-ring" cavity that meets the constraints of thin-SOI microelectronics CMOS processes and enables energy efficient modulators and thermally tunable filters. For low-loss fiber-to-chip optical coupling, a phased-array antenna concept is demonstrated, and the 45 nm CMOS microelectronics process is shown to support a near ideal implementation of the device using the crystalline silicon and polysilicon material layers that comprise the active region and gate, respectively, of the native MOSFET transistors. The active devices and vertical grating couplers are implemented in large-scale electronic-photonic systems-on-chip to demonstrate a wavelength stabilized, microring-based chip-to-chip communications link and an 11-channel wavelength division multiplexed (WDM) transmitter. The link is shown to be robust against thermal environmental variations which is critical for operation in realistic systems. The chip-to-chip link is then used to demonstrate a CPU-to-memory communication link, the first demonstration of its kind. The first microprocessor with photonic I/O is demonstrated as part of this work, with substantial implications for computer architecture. Advanced photonic device technology demonstrations, including photonic crystals, a quantum-correlated photon-pair source, an active photonic device platform in a 32 nm SOI node, and a 180 nm bulk silicon process, are presented to show the wide range of applications that monolithic integration could support in the future of photonics. These results taken together show that monolithic integration directly into CMOS microelectronics processes does allow high performance photonics, and is a viable approach to build large-scale electronic-photonic systems with a realistic path to

  4. Microfluidic Pneumatic Logic Circuits and Digital Pneumatic Microprocessors for Integrated Microfluidic Systems

    PubMed Central

    Rhee, Minsoung

    2010-01-01

    We have developed pneumatic logic circuits and microprocessors built with microfluidic channels and valves in polydimethylsiloxane (PDMS). The pneumatic logic circuits perform various combinational and sequential logic calculations with binary pneumatic signals (atmosphere and vacuum), producing cascadable outputs based on Boolean operations. A complex microprocessor is constructed from combinations of various logic circuits and receives pneumatically encoded serial commands at a single input line. The device then decodes the temporal command sequence by spatial parallelization, computes necessary logic calculations between parallelized command bits, stores command information for signal transportation and maintenance, and finally executes the command for the target devices. Thus, such pneumatic microprocessors will function as a universal on-chip control platform to perform complex parallel operations for large-scale integrated microfluidic devices. To demonstrate the working principles, we have built 2-bit, 3-bit, 4-bit, and 8-bit microprecessors to control various target devices for applications such as four color dye mixing, and multiplexed channel fluidic control. By significantly reducing the need for external controllers, the digital pneumatic microprocessor can be used as a universal on-chip platform to autonomously manipulate microfluids in a high throughput manner. PMID:19823730

  5. A Microprocessor Project for Non-Electrical Engineering Students.

    ERIC Educational Resources Information Center

    Swingler, D. N.

    1981-01-01

    Offers rationale for and a description of a microprocessor-based control system project for mechanical engineering students. Includes reasons for selecting a Texas Instruments TM990/189 microprocessor system. (SK)

  6. Microprocessor prosthetic knees.

    PubMed

    Berry, Dale

    2006-02-01

    This article traces the development of microprocessor prosthetic knees from early research in the 1970s to the present. Read about how microprocessor knees work, functional options, patient selection, and the future of this prosthetic.

  7. Microprocessors in Schools?

    ERIC Educational Resources Information Center

    Cuthbert, L. G.

    1981-01-01

    Examines reasons for including microprocessors in school curricula. Indicates that practical work with microprocessors is not easy and discusses problems associated with using and constructing these control and processing devices of microcomputers. (SK)

  8. Cumulative Timers for Microprocessors

    NASA Technical Reports Server (NTRS)

    Battle, John O.

    2007-01-01

    It has been proposed to equip future microprocessors with electronic cumulative timers, for essentially the same reasons for which land vehicles are equipped with odometers (total-distance-traveled meters) and aircraft are equipped with Hobbs meters (total-engine-operating time meters). Heretofore, there has been no way to determine the amount of use to which a microprocessor (or a product containing a microprocessor) has been subjected. The proposed timers would count all microprocessor clock cycles and could only be read by means of microprocessor instructions but, like odometers and Hobbs meters, could never be reset to zero without physically damaging the chip.

  9. Microprocessor aided data acquisition at VEDAS

    SciTech Connect

    Ziem, P.; Drescher, B.; Kapper, K.; Kowallik, R.

    1985-08-01

    Three microprocessor systems have been developed to support data acquisition in nuclear physics multiparameter experiments. A bit-slice processor accumulates up to 256 1-dim spectra and 16 2-dim spectra. A microprocessor, based on the AM 29116 ALU, performs a fast consistency check on the coincidence data. A VME-Bus double-processor displays a colored scatterplot.

  10. Microprocessors in the Curriculum and the Classroom.

    ERIC Educational Resources Information Center

    Summers, M. K.

    1978-01-01

    This article, directed at teachers concerned with computer science courses at sixth-form level with no prior knowledge of microprocessors, provides a basic introduction, and describes possible applications of a microprocessor development system as a teaching aid in computer sciences courses in UK secondary school. (Author/RAO)

  11. Verification of the FtCayuga fault-tolerant microprocessor system. Volume 2: Formal specification and correctness theorems

    NASA Technical Reports Server (NTRS)

    Bickford, Mark; Srivas, Mandayam

    1991-01-01

    Presented here is a formal specification and verification of a property of a quadruplicately redundant fault tolerant microprocessor system design. A complete listing of the formal specification of the system and the correctness theorems that are proved are given. The system performs the task of obtaining interactive consistency among the processors using a special instruction on the processors. The design is based on an algorithm proposed by Pease, Shostak, and Lamport. The property verified insures that an execution of the special instruction by the processors correctly accomplishes interactive consistency, providing certain preconditions hold, using a computer aided design verification tool, Spectool, and the theorem prover, Clio. A major contribution of the work is the demonstration of a significant fault tolerant hardware design that is mechanically verified by a theorem prover.

  12. Small Microprocessor for ASIC or FPGA Implementation

    NASA Technical Reports Server (NTRS)

    Kleyner, Igor; Katz, Richard; Blair-Smith, Hugh

    2011-01-01

    A small microprocessor, suitable for use in applications in which high reliability is required, was designed to be implemented in either an application-specific integrated circuit (ASIC) or a field-programmable gate array (FPGA). The design is based on commercial microprocessor architecture, making it possible to use available software development tools and thereby to implement the microprocessor at relatively low cost. The design features enhancements, including trapping during execution of illegal instructions. The internal structure of the design yields relatively high performance, with a significant decrease, relative to other microprocessors that perform the same functions, in the number of microcycles needed to execute macroinstructions. The problem meant to be solved in designing this microprocessor was to provide a modest level of computational capability in a general-purpose processor while adding as little as possible to the power demand, size, and weight of a system into which the microprocessor would be incorporated. As designed, this microprocessor consumes very little power and occupies only a small portion of a typical modern ASIC or FPGA. The microprocessor operates at a rate of about 4 million instructions per second with clock frequency of 20 MHz.

  13. Aerospace Applications of Microprocessors

    NASA Technical Reports Server (NTRS)

    1980-01-01

    An assessment of the state of microprocessor applications is presented. Current and future requirements and associated technological advances which allow effective exploitation in aerospace applications are discussed.

  14. Laboratory Implementation of the Continuously Reconfiguring Multi-Microprocessor Flight Control System (CRMMFCS)

    DTIC Science & Technology

    1989-10-01

    partial or total failure of processing elements or transmitting units. Given the spectrum of fault possibilities, the system of fault detection and isolation mechanisms...must be able to cover a wide area. A single fault detection and isolation mechanism will not be able to cover this entire area...CRMMFCS uses multiple fault detection and isolation mechanisms which overlap each other. In this way, failures which pass one or more types of tests is

  15. Power-supply regulation by microprocessor

    SciTech Connect

    Sheehan, J.; Langenbach, H.

    1983-01-01

    Many small-magnet power supplies are regulated by using a microprocessor system to generate control voltages to continuously servoregulate each power supply. The power supplies are of very simple design since all regulation and feedback hardware are parts of the microprocessor system. Most of the supplies are bipolar transistor followers, powered by a common unregulated dc power supply and are used to power trim steering magnets on the three NSLS synchrotron rings. Twelve-bit accuracy is obtained using commercially available microprocessor pc cards.

  16. Microprocessor Seminar, phase 2

    NASA Technical Reports Server (NTRS)

    Scott, W. R.

    1977-01-01

    Workshop sessions and papers were devoted to various aspects of microprocessor and large scale integrated circuit technology. Presentations were made on advanced LSI developments for high reliability military and NASA applications. Microprocessor testing techniques were discussed, and test data were presented. High reliability procurement specifications were also discussed.

  17. Microprocessors and the Curriculum.

    ERIC Educational Resources Information Center

    Pasahow, Edward J.

    1981-01-01

    Presents three approaches to teaching the use of a microprocessor: (1) a "generic" device on paper; (2) a "conglomeration" device, surveying a number of real products; and (3) the "how" course which covers a small number of actual but related microprocessors. (CT)

  18. A microprocessor based high speed packet switch for satellite communications

    NASA Technical Reports Server (NTRS)

    Arozullah, M.; Crist, S. C.

    1980-01-01

    The architectures of a single processor, a three processor, and a multiple processor system are described. The hardware circuits, and software routines required for implementing the three and multiple processor designs are presented. A bit-slice microprocessor was designed and microprogrammed. Maximum throughput was calculated for all three designs. Queue theoretic models for these three designs were developed and utilized to obtain analytical expressions for the average waiting times, overall average response times and average queue sizes. From these expressions, graphs were obtained showing the effect on the system performance of a number of design parameters.

  19. Non-radiation hardened microprocessors in space-based remote sensing systems

    NASA Astrophysics Data System (ADS)

    DeCoursey, R.; Melton, Ryan; Estes, Robert R., Jr.

    2006-09-01

    The CALIPSO (Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observations) mission is a comprehensive suite of active and passive sensors including a 20Hz 230mj Nd:YAG lidar, a visible wavelength Earth-looking camera and an imaging infrared radiometer. CALIPSO flies in formation with the Earth Observing System Post-Meridian (EOS PM) train, provides continuous, near-simultaneous measurements and is a planned 3 year mission. CALIPSO was launched into a 98 degree sun synchronous Earth orbit in April of 2006 to study clouds and aerosols and acquires over 5 gigabytes of data every 24 hours. Figure 1 shows the ground track of one CALIPSO orbit as well as high and low intensity South Atlantic Anomaly outlines. CALIPSO passes through the SAA several times each day. Spaced based remote sensing systems that include multiple instruments and/or instruments such as lidar generate large volumes of data and require robust real-time hardware and software mechanisms and high throughput processors. Due to onboard storage restrictions and telemetry downlink limitations these systems must pre-process and reduce the data before sending it to the ground. This onboard processing and realtime requirement load may mean that newer more powerful processors are needed even though acceptable radiation-hardened versions have not yet been released. CALIPSO's single board computer payload controller processor is actually a set of four (4) voting non-radiation hardened COTS Power PC 603r's built on a single width VME card by General Dynamics Advanced Information Systems (GDAIS). Significant radiation concerns for CALIPSO and other Low Earth Orbit (LEO) satellites include the South Atlantic Anomaly (SAA), the north and south poles and strong solar events. Over much of South America and extending into the South Atlantic Ocean (see figure 1) the Van Allen radiation belts dip to just 200-800km and spacecraft entering this area are subjected to high energy protons and experience higher than

  20. Microprocessor control of multiple peak power tracking DC/DC converters for use with solar cell arrays

    NASA Technical Reports Server (NTRS)

    Frederick, Martin E. (Inventor); Jermakian, Joel (Inventor)

    1991-01-01

    A method and an apparatus is provided for efficiently controlling the power output of a solar cell array string or a plurality of solar cell array strings to achieve a maximum amount of output power from the strings under varying conditions of use. Maximum power output from a solar array string is achieved through control of a pulse width modulated DC/DC buck converter which transfers power from a solar array to a load or battery bus. The input voltage from the solar array to the converter is controlled by a pulse width modulation duty cycle, which in turn is controlled by a differential signal controller. By periodically adjusting the control voltage up or down by a small amount and comparing the power on the load or bus with that generated at different voltage values a maximum power output voltage may be obtained. The system is totally modular and additional solar array strings may be added to the system simply by adding converter boards to the system and changing some constants in the controller's control routines.

  1. Feasibility study of microprocessor systems suitable for use in developing a real-time for the 4.75 GHz scatterometer

    NASA Technical Reports Server (NTRS)

    1977-01-01

    A class of signal processors suitable for the reduction of radar scatterometer data in real time was developed. The systems were applied to the reduction of single polarized 13.3 GHz scatterometer data and provided a real time output of radar scattering coefficient as a function of incident angle. It was proposed that a system for processing of C band radar data be constructed to support scatterometer system currently under development. The establishment of a feasible design approach to the development of this processor system utilizing microprocessor technology was emphasized.

  2. Generic interpreters and microprocessor verification

    NASA Technical Reports Server (NTRS)

    Windley, Phillip J.

    1990-01-01

    The following topics are covered in viewgraph form: (1) generic interpreters; (2) Viper microprocessors; (3) microprocessor verification; (4) determining correctness; (5) hierarchical decomposition; (6) interpreter theory; (7) AVM-1; (8) phase-level specification; and future work.

  3. Monolithic silicon photonics in a sub-100nm SOI CMOS microprocessor foundry: progress from devices to systems

    NASA Astrophysics Data System (ADS)

    Popović, Miloš A.; Wade, Mark T.; Orcutt, Jason S.; Shainline, Jeffrey M.; Sun, Chen; Georgas, Michael; Moss, Benjamin; Kumar, Rajesh; Alloatti, Luca; Pavanello, Fabio; Chen, Yu-Hsin; Nammari, Kareem; Notaros, Jelena; Atabaki, Amir; Leu, Jonathan; Stojanović, Vladimir; Ram, Rajeev J.

    2015-02-01

    We review recent progress of an effort led by the Stojanović (UC Berkeley), Ram (MIT) and Popović (CU Boulder) research groups to enable the design of photonic devices, and complete on-chip electro-optic systems and interfaces, directly in standard microelectronics CMOS processes in a microprocessor foundry, with no in-foundry process modifications. This approach allows tight and large-scale monolithic integration of silicon photonics with state-of-the-art (sub-100nm-node) microelectronics, here a 45nm SOI CMOS process. It enables natural scale-up to manufacturing, and rapid advances in device design due to process repeatability. The initial driver application was addressing the processor-to-memory communication energy bottleneck. Device results include 5Gbps modulators based on an interleaved junction that take advantage of the high resolution of the sub-100nm CMOS process. We demonstrate operation at 5fJ/bit with 1.5dB insertion loss and 8dB extinction ratio. We also demonstrate the first infrared detectors in a zero-change CMOS process, using absorption in transistor source/drain SiGe stressors. Subsystems described include the first monolithically integrated electronic-photonic transmitter on chip (modulator+driver) with 20-70fJ/bit wall plug energy/bit (2-3.5Gbps), to our knowledge the lowest transmitter energy demonstrated to date. We also demonstrate native-process infrared receivers at 220fJ/bit (5Gbps). These are encouraging signs for the prospects of monolithic electronics-photonics integration. Beyond processor-to-memory interconnects, our approach to photonics as a "More-than- Moore" technology inside advanced CMOS promises to enable VLSI electronic-photonic chip platforms tailored to a vast array of emerging applications, from optical and acoustic sensing, high-speed signal processing, RF and optical metrology and clocks, through to analog computation and quantum technology.

  4. [Anesthesiological systems "Polinarkon-Vita" with microprocessor for artificial lung ventilation apparatuses and monitoring].

    PubMed

    Trushin, A I; Uliakov, G I; Reĭderman, E N

    2005-01-01

    The anesthesiological systems Polinarkon-Vita for adults and children are described. These systems were developed at VNIIMP-VITA, Ltd. on the basis of basic model of the anesthesiological system Polinarkon-E-Vita. The following new important units of the fifth generation apparatuses for inhalation anesthesia (IA) are described: Anestezist-4 monocomponent evaporator for liquid anesthetics (enfluran and isofluran); Diana, Diana-Det, and Elan-NR apparatuses for mechanical lung ventilation (MLV); dosimeters of medical gases, etc. These systems implement monitoring of vitally important functions of patient and parameters of IN and MLV. The anesthesiological systems Polinarkon-Vita are recommended for medical practice and commercially available from VNIIMP-VITA, Ltd. as small lots.

  5. A microprocessor-controlled tracheal insufflation-assisted total liquid ventilation system.

    PubMed

    Parker, James Courtney; Sakla, Adel; Donovan, Francis M; Beam, David; Chekuri, Annu; Al-Khatib, Mohammad; Hamm, Charles R; Eyal, Fabien G

    2009-09-01

    A prototype time cycled, constant volume, closed circuit perfluorocarbon (PFC) total liquid ventilator system is described. The system utilizes microcontroller-driven display and master control boards, gear motor pumps, and three-way solenoid valves to direct flow. A constant tidal volume and functional residual capacity (FRC) are maintained with feedback control using end-expiratory and end-inspiratory stop-flow pressures. The system can also provide a unique continuous perfusion (bias flow, tracheal insufflation) through one lumen of a double-lumen endotracheal catheter to increase washout of dead space liquid. FRC and arterial blood gases were maintained during ventilation with Rimar 101 PFC over 2-3 h in normal piglets and piglets with simulated pulmonary edema induced by instillation of albumin solution. Addition of tracheal insufflation flow significantly improved the blood gases and enhanced clearance of instilled albumin solution during simulated edema.

  6. Microprocessor control system for output power optimization of a wind turbine

    SciTech Connect

    Eriksson, M.; Ottosson, J.; Wolpert, T.

    1983-10-01

    The wind turbine used in ERICSSON SUNWIND is a combined Darrieus-Savonius type, in which the Darrieus turbine produces most of the energy, whereas Savonius rotor supplies a starting torque. The particular requirements and difficulties connected with the output power control of a Darrieus turbine are presented and analysed. In order to meet these requirements an adaptive control system based on microcomputer techniques has been developed. This paper describes the principle of operation, the hardware and the software of the control system. An illustration of the practical operation in a test plant is also given.

  7. System of thermostatic control on Peltier thermopiles and microprocessor control for a portable NMR relaxometer.

    PubMed

    Anisimov, Alexander V; Teplov, Vadim Yu; Silkin, Nikolai I

    2002-02-01

    Liquid equipment for thermostatic control of samples with accuracy better than 0.1 degree C within the temperature range from -20 to +70 degree C is designed for small-sized NMR spectrometers. The difficulty in using this equipment is a thermomodule based on the Peltier effect. The temperature control system is based on a single crystal microcomputer. The equipment fits modern small-sized NMR spectrometers, which facilitates medical and biological studies.

  8. Automated mixed traffic transit vehicle microprocessor controller

    NASA Technical Reports Server (NTRS)

    Marks, R. A.; Cassell, P.; Johnston, A. R.

    1981-01-01

    An improved Automated Mixed Traffic Vehicle (AMTV) speed control system employing a microprocessor and transistor chopper motor current controller is described and its performance is presented in terms of velocity versus time curves. The on board computer hardware and software systems are described as is the software development system. All of the programming used in this controller was implemented using FORTRAN. This microprocessor controller made possible a number of safety features and improved the comfort associated with starting and shopping. In addition, most of the vehicle's performance characteristics can be altered by simple program parameter changes. A failure analysis of the microprocessor controller was generated and the results are included. Flow diagrams for the speed control algorithms and complete FORTRAN code listings are also included.

  9. A fast microprocessor communication network design for interprocessor communications for an integrated flight control system

    NASA Technical Reports Server (NTRS)

    Kelly, G. L.; Jiang, P.-W.

    1982-01-01

    A node design with connectivity four is presented whose communication processor handles data at four million bits/sec on each of the four channels into the node, and on each of the four channels out of the node, for a total node capacity of 32 million bits/sec. An integrated flight control system real-time application of this communication network design is discussed. It is shown that such high speed node communication hardware, arranged in the topological configuration of a minimum diameter graph with connectivity four and all links active, has good potential for real time control applications requiring reliability, availability, and survivability characteristics.

  10. Enhancement of a radiation safety system through the use of a microprocessor-controlled speech synthesizer

    SciTech Connect

    Keefe, D.J.; McDowell, W.P.

    1980-01-01

    A speech synthesizer is being used to differentiate eight separate safety alarms on a high energy accelerator at Argonne National Laboratory. A single board microcomputer monitors eight signals from an existing radiation safety logic circuit. The microcomputer is programmed to output the proper code at the proper time and sequence to a speech synthesizer which supplies the audio input to a local public address system. This eliminates the requirement for eight different alarm tones and the personnel training required to differentiate among them. A twenty-word vocabulary was found adequate to supply the necessary safety announcements. The article describes the techniques used to interface the speech synthesizer into the existing safety logic circuit.

  11. Synchronous clock stopper for microprocessor

    NASA Technical Reports Server (NTRS)

    Kitchin, David A. (Inventor)

    1985-01-01

    A synchronous clock stopper circuit for inhibiting clock pulses to a microprocessor in response to a stop request signal, and for reinstating the clock pulses in response to a start request signal thereby to conserve power consumption of the microprocessor when used in an environment of limited power. The stopping and starting of the microprocessor is synchronized, by a phase tracker, with the occurrences of a predetermined phase in the instruction cycle of the microprocessor in which the I/O data and address lines of the microprocessor are of high impedance so that a shared memory connected to the I/O lines may be accessed by other peripheral devices. The starting and stopping occur when the microprocessor initiates and completes, respectively, an instruction, as well as before and after transferring data with a memory. Also, the phase tracker transmits phase information signals over a bus to other peripheral devices which signals identify the current operational phase of the microprocessor.

  12. Microprocessor-based cardiotachometer

    NASA Technical Reports Server (NTRS)

    Crosier, W. G.; Donaldson, J. A.

    1981-01-01

    Instrument operates reliably even with stress-test electrocardiogram (ECG) signals subject to noise, baseline wandering, and amplitude change. It records heart rate from preamplified, single-lead ECG input signal and produces digital and analog heart-rate outputs which are fed elsewhere. Analog hardware processes ECG input signal, producing 10-ms pulse for each heartbeat. Microprocessor analyzes resulting pulse train, identifying irregular heartbeats and maintaining stable output during lead switching. Easily modified computer program provides analysis.

  13. Microprocessor Design Using Hardware Description Language

    ERIC Educational Resources Information Center

    Mita, Rosario; Palumbo, Gaetano

    2008-01-01

    The following paper has been conceived to deal with the contents of some lectures aimed at enhancing courses on digital electronic, microelectronic or VLSI systems. Those lectures show how to use a hardware description language (HDL), such as the VHDL, to specify, design and verify a custom microprocessor. The general goal of this work is to teach…

  14. Could a Neuroscientist Understand a Microprocessor?

    PubMed Central

    Kording, Konrad Paul

    2017-01-01

    There is a popular belief in neuroscience that we are primarily data limited, and that producing large, multimodal, and complex datasets will, with the help of advanced data analysis algorithms, lead to fundamental insights into the way the brain processes information. These datasets do not yet exist, and if they did we would have no way of evaluating whether or not the algorithmically-generated insights were sufficient or even correct. To address this, here we take a classical microprocessor as a model organism, and use our ability to perform arbitrary experiments on it to see if popular data analysis methods from neuroscience can elucidate the way it processes information. Microprocessors are among those artificial information processing systems that are both complex and that we understand at all levels, from the overall logical flow, via logical gates, to the dynamics of transistors. We show that the approaches reveal interesting structure in the data but do not meaningfully describe the hierarchy of information processing in the microprocessor. This suggests current analytic approaches in neuroscience may fall short of producing meaningful understanding of neural systems, regardless of the amount of data. Additionally, we argue for scientists using complex non-linear dynamical systems with known ground truth, such as the microprocessor as a validation platform for time-series and structure discovery methods. PMID:28081141

  15. Modular strapdown guidance unit with embedded microprocessors

    NASA Astrophysics Data System (ADS)

    Gilmore, J. P.

    1980-02-01

    The Low-Cost Inertial Guidance System (LCIGS) is a modular strapdown implementation of attitude (gyro) and velocity (accelerometer) axes which permits the interchangeable use of different manufacturer's instruments without affecting the system's electronic or mechanical interfaces or processing software. This design flexibility is made possible by the use of microprocessors for processing and control. The microprocessors are embedded in each module and five are used: one per accelerometer triad, one each per gyro module, and one in the service module. The processors effect on-line digital torquing control of the gyros, active instrument error model compensation, including modeling for temperature sensitivity effects, temperature control, self-testing, etc. Adaptation of processing and calibration algorithms to accommodate for instrument changes or sensed environmental variations is achieved through the use of an alterable read-only data base that may be updated by the LCIGS support equipment as required at calibrations or upon an instrument replacement. This data base is accessed by the microprocessors and used to compute coefficient corrections for the processing algorithms. The system architecture is presented and the microprocessor software partitioning and functions are described.

  16. Could a Neuroscientist Understand a Microprocessor?

    PubMed

    Jonas, Eric; Kording, Konrad Paul

    2017-01-01

    There is a popular belief in neuroscience that we are primarily data limited, and that producing large, multimodal, and complex datasets will, with the help of advanced data analysis algorithms, lead to fundamental insights into the way the brain processes information. These datasets do not yet exist, and if they did we would have no way of evaluating whether or not the algorithmically-generated insights were sufficient or even correct. To address this, here we take a classical microprocessor as a model organism, and use our ability to perform arbitrary experiments on it to see if popular data analysis methods from neuroscience can elucidate the way it processes information. Microprocessors are among those artificial information processing systems that are both complex and that we understand at all levels, from the overall logical flow, via logical gates, to the dynamics of transistors. We show that the approaches reveal interesting structure in the data but do not meaningfully describe the hierarchy of information processing in the microprocessor. This suggests current analytic approaches in neuroscience may fall short of producing meaningful understanding of neural systems, regardless of the amount of data. Additionally, we argue for scientists using complex non-linear dynamical systems with known ground truth, such as the microprocessor as a validation platform for time-series and structure discovery methods.

  17. Verification of the FtCayuga fault-tolerant microprocessor system. Volume 1: A case study in theorem prover-based verification

    NASA Technical Reports Server (NTRS)

    Srivas, Mandayam; Bickford, Mark

    1991-01-01

    The design and formal verification of a hardware system for a task that is an important component of a fault tolerant computer architecture for flight control systems is presented. The hardware system implements an algorithm for obtaining interactive consistancy (byzantine agreement) among four microprocessors as a special instruction on the processors. The property verified insures that an execution of the special instruction by the processors correctly accomplishes interactive consistency, provided certain preconditions hold. An assumption is made that the processors execute synchronously. For verification, the authors used a computer aided design hardware design verification tool, Spectool, and the theorem prover, Clio. A major contribution of the work is the demonstration of a significant fault tolerant hardware design that is mechanically verified by a theorem prover.

  18. OS friendly microprocessor architecture: Hardware level computer security

    NASA Astrophysics Data System (ADS)

    Jungwirth, Patrick; La Fratta, Patrick

    2016-05-01

    We present an introduction to the patented OS Friendly Microprocessor Architecture (OSFA) and hardware level computer security. Conventional microprocessors have not tried to balance hardware performance and OS performance at the same time. Conventional microprocessors have depended on the Operating System for computer security and information assurance. The goal of the OS Friendly Architecture is to provide a high performance and secure microprocessor and OS system. We are interested in cyber security, information technology (IT), and SCADA control professionals reviewing the hardware level security features. The OS Friendly Architecture is a switched set of cache memory banks in a pipeline configuration. For light-weight threads, the memory pipeline configuration provides near instantaneous context switching times. The pipelining and parallelism provided by the cache memory pipeline provides for background cache read and write operations while the microprocessor's execution pipeline is running instructions. The cache bank selection controllers provide arbitration to prevent the memory pipeline and microprocessor's execution pipeline from accessing the same cache bank at the same time. This separation allows the cache memory pages to transfer to and from level 1 (L1) caching while the microprocessor pipeline is executing instructions. Computer security operations are implemented in hardware. By extending Unix file permissions bits to each cache memory bank and memory address, the OSFA provides hardware level computer security.

  19. Retrofitting of multiple control systems

    SciTech Connect

    Sullivan, G.F.; Coles, J.E.

    1984-01-01

    In these days when distributed micro-processor control systems are being hailed as the way to go in new power plants, the question of replacing worn-out and obsolete control systems in existing power plants presents a real dilemma. The cost of these systems and their non-compatibility with much of the existing hardware makes them unattractive for retrofits. After almost a year of study and cost comparisons, it was decided five years ago that the most painless way of resolving that problem in our 15-28 year old plant was to distribute various plant instrumentation and control functions in a few mini-computers and to break this project into several time phases, thereby spreading the capital expenditures over several years. In prosecuting the project, a step backwards was taken from the direction plant instrumentation and controls is heading today, ending up with all of our eggs in one basket - almost, but gaining a quantum increase in control system reliability and performance, plus the capability to add new unrelated loops and functions as required. The system is described.

  20. Microprocessor applications in reentry vehicle testing

    NASA Astrophysics Data System (ADS)

    Downing, W. D., Jr.; Winn, B. D.; Pruett, J. P.

    A system to test the Minuteman MK-12 reentry vehicle is being developed by Southwest Research Institute for use at Kelly AFB. The system will use several microprocessors to monitor and direct the test functions, control the flight environment equipment and measure reentry vehicle performance. Data acquired during the test are used for reliability scoring. The new system is intended to replace the original system which has been in operation sicne 1968. This paper will provide a description of each microprocessor system and its associated peripherals and software. Emphasis will be given to and distribution of critical tasks among processors and development of fault tolerant software in order to increase system reliability. Testing has been conducted for several years, revealing many areas that need improvement. Some of the problems encountered, and the solutions to those problems, will be discussed.

  1. Autoregulatory mechanisms controlling the Microprocessor.

    PubMed

    Triboulet, Robinson; Gregory, Richard I

    2010-01-01

    The Microprocessor, comprising the ribonuclease Drosha and its essential cofactor, the double-stranded RNA-binding protein, DGCR8, is essential for the first step of the miRNA biogenesis pathway. It specifically cleaves double-stranded RNA within stem-loop structures of primary miRNA transcripts (pri-miRNAs) to generate precursor (pre-miRNA) intermediates. Pre-miRNAs are subsequently processed by Dicer to their mature 22 nt form. Thus, Microprocessor is essential for miRNA maturation, and pri-miRNA cleavage by this complex defines one end of the mature miRNA. Moreover, it is emerging that dysregulation of the Microprocessor is associated with various human diseases. It is therefore important to understand the mechanisms by which the expression of the subunits of the Microprocessor is regulated. Recent findings have uncovered a post-transcriptional mechanism that maintains the integrity of the Microprocessor. These studies revealed that the Microprocessor is involved in the processing of the messenger RNA (mRNA) that encodes DGCR8. This regulatory feedback loop, along with the reported role played by DGCR8 in the stabilization of Drosha protein, is part ofa newly identified regulatory mechanism controlling Microprocessor activity.

  2. Autoregulatory mechanisms controlling the microprocessor.

    PubMed

    Triboulet, Robinson; Gregory, Richard I

    2011-01-01

    The Microprocessor, comprising the ribonuclease Drosha and its essential cofactor, the double-stranded RNA-binding protein, DGCR8, is essential for the first step of the miRNA biogenesis pathway. It specifically cleaves double-stranded RNA within stem-loop structures of primary miRNA transcripts (pri-miRNAs) to generate precursor (pre-miRNA) intermediates. Pre-miRNAs are subsequently processed by Dicer to their mature ∼22 nt form. Thus, Microprocessor is essential for miRNA maturation, and pri-miRNA cleavage by this complex defines one end of the mature miRNA. Moreover, it is emerging that dysregulation of the Microprocessor is associated with various human diseases. It is therefore important to understand the mechanisms by which the expression of the subunits of the Microprocessor is regulated. Recent findings have uncovered a post-transcriptional mechanism that maintains the integrity of the Microprocessor. These studies revealed that the Microprocessor is involved in the processing of the messenger RNA (mRNA) that encodes DGCR8. This regulatory feedback loop, along with the reported role played by DGCR8 in the stabilization of Drosha protein, is part of a newly identified regulatory mechanism controlling Microprocessor activity.

  3. The design of a microprocessor-based data logger

    USGS Publications Warehouse

    Leap, K.J.; Dedini, L.A.

    1982-01-01

    The design of a microprocessor-based data logger, which collects and digitizes analog voltage signals from a continuous-measuring instrumentation system and transmits serial data to a magnetic tape recorder, is discussed. The data logger was assembled from commercially-available components and can be user-programmed for greater flexibility. A description of the data logger hardware and software designs, general operating instructions, the microprocessor program listing, and electrical schematic diagrams are presented.

  4. Microprocessors in physics experiments at SLAC

    SciTech Connect

    Rochester, L.S.

    1981-04-01

    The increasing size and complexity of high energy physics experiments is changing the way data are collected. To implement a trigger or event filter requires complex logic which may have to be modified as the experiment proceeds. Simply to monitor a detector, large amounts of data must be processed on line. The use of microprocessors or other programmable devices can help to achieve these ends flexibly and economically. At SLAC, a number of microprocessor-based systems have been built and are in use in experimental setups, and others are now being developed. This talk is a review of existing systems and their use in experiments, and of developments in progress and future plans.

  5. Formal verification of an avionics microprocessor

    NASA Technical Reports Server (NTRS)

    Srivas, Mandayam, K.; Miller, Steven P.

    1995-01-01

    Formal specification combined with mechanical verification is a promising approach for achieving the extremely high levels of assurance required of safety-critical digital systems. However, many questions remain regarding their use in practice: Can these techniques scale up to industrial systems, where are they likely to be useful, and how should industry go about incorporating them into practice? This report discusses a project undertaken to answer some of these questions, the formal verification of the AAMPS microprocessor. This project consisted of formally specifying in the PVS language a rockwell proprietary microprocessor at both the instruction-set and register-transfer levels and using the PVS theorem prover to show that the microcode correctly implemented the instruction-level specification for a representative subset of instructions. Notable aspects of this project include the use of a formal specification language by practicing hardware and software engineers, the integration of traditional inspections with formal specifications, and the use of a mechanical theorem prover to verify a portion of a commercial, pipelined microprocessor that was not explicitly designed for formal verification.

  6. Safety and walking ability of KAFO users with the C-Brace® Orthotronic Mobility System, a new microprocessor stance and swing control orthosis

    PubMed Central

    Pröbsting, Eva; Kannenberg, Andreas; Zacharias, Britta

    2016-01-01

    Background: There are clear indications for benefits of stance control orthoses compared to locked knee ankle foot orthoses. However, stance control orthoses still have limited function compared with a sound human leg. Objectives: The aim of this study was to evaluate the potential benefits of a microprocessor stance and swing control orthosis compared to stance control orthoses and locked knee ankle foot orthoses in activities of daily living. Study design: Survey of lower limb orthosis users before and after fitting of a microprocessor stance and swing control orthosis. Methods: Thirteen patients with various lower limb pareses completed a baseline survey for their current orthotic device (locked knee ankle foot orthosis or stance control orthosis) and a follow-up for the microprocessor stance and swing control orthosis with the Orthosis Evaluation Questionnaire, a new self-reported outcome measure devised by modifying the Prosthesis Evaluation Questionnaire for use in lower limb orthotics and the Activities of Daily Living Questionnaire. Results: The Orthosis Evaluation Questionnaire results demonstrated significant improvements by microprocessor stance and swing control orthosis use in the total score and the domains of ambulation (p = .001), paretic limb health (p = .04), sounds (p = .02), and well-being (p = .01). Activities of Daily Living Questionnaire results showed significant improvements with the microprocessor stance and swing control orthosis with regard to perceived safety and difficulty of activities of daily living. Conclusion: The microprocessor stance and swing control orthosis may facilitate an easier, more physiological, and safer execution of many activities of daily living compared to traditional leg orthosis technologies. Clinical relevance This study compared patient-reported outcomes of a microprocessor stance and swing control orthosis (C-Brace) to those with traditional knee ankle foot orthosis and stance control orthosis

  7. Cellular functions of the microprocessor.

    PubMed

    Macias, Sara; Cordiner, Ross A; Cáceres, Javier F

    2013-08-01

    The microprocessor is a complex comprising the RNase III enzyme Drosha and the double-stranded RNA-binding protein DGCR8 (DiGeorge syndrome critical region 8 gene) that catalyses the nuclear step of miRNA (microRNA) biogenesis. DGCR8 recognizes the RNA substrate, whereas Drosha functions as an endonuclease. Recent global analyses of microprocessor and Dicer proteins have suggested novel functions for these components independent of their role in miRNA biogenesis. A HITS-CLIP (high-throughput sequencing of RNA isolated by cross-linking immunoprecipitation) experiment designed to identify novel substrates of the microprocessor revealed that this complex binds and regulates a large variety of cellular RNAs. The microprocessor-mediated cleavage of several classes of RNAs not only regulates transcript levels, but also modulates alternative splicing events, independently of miRNA function. Importantly, DGCR8 can also associate with other nucleases, suggesting the existence of alternative DGCR8 complexes that may regulate the fate of a subset of cellular RNAs. The aim of the present review is to provide an overview of the diverse functional roles of the microprocessor.

  8. Single-event upset in advanced commercial power PC microprocessors

    NASA Technical Reports Server (NTRS)

    Irom, F.; Farmanesh, F.; Swift, G. M.; Johnston, A. H.

    2003-01-01

    Single-event upset from heavy ions in measured for advanced commercial microprocessors, comparing upset sensitivity in registers and d-cache for several generations of devices. Multiple-bit upsets and asymmetry in registers upset cross sections are also discussed.

  9. Microprocessor utilization in search and rescue missions

    NASA Technical Reports Server (NTRS)

    Schwartz, M.

    1977-01-01

    The feasibility of performing the same task in real time using microprocessor technology was determined. The least square algorithm was implemented on an Intel 8080 microprocessor. Results indicated that a microprocessor could easily match the IBM implementation in accuracy and be performed inside the time limitations set.

  10. Daily weather direct readout microprocessor study

    NASA Technical Reports Server (NTRS)

    Davisson, L. D.; Davisson, J. B.

    1976-01-01

    The work completed included a study of the requirements and hardware and software implementation techniques for NIMBUS ESMR and TWERLE direct readout applications using microprocessors. Many microprocessors were studied for this application. Because of the available Interdata development capabilities, it was concluded that future implementations be on an Interdata microprocessor which was found adequate for the task.

  11. Kepler's Multiple Planet Systems

    NASA Technical Reports Server (NTRS)

    Lissauer, Jack J.

    2012-01-01

    Among the 1800 Kepler targets that have candidate planets, 20% have two or more candidate planets. While most of these objects have not yet been confirmed as true planets, several considerations strongly suggest that the vast majority of these multi-candidate systems are true planetary systems. Virtually all candidate systems are stable, as tested by numerical integrations (assuming a nominal mass-radius relationship). Statistical studies performed on these candidates reveal a great deal about the architecture of planetary systems, including the typical spacing of orbits and flatness of planetary systems. The distribution of observed period ratios shows that the vast majority of candidate pairs are neither in nor near low-order mean motion resonances. Nonetheless, there are small but statistically significant excesses of candidate pairs both in resonance and spaced slightly too far apart to be in resonance, particularly near the 2:1 resonance. The characteristics of the confirmed Kepler multi-planet systems will also be discussed.

  12. Microprocessor-Based Hourmeter For Maintenance

    NASA Astrophysics Data System (ADS)

    Chin, Teck-Chai

    1987-01-01

    A low-cost data acquisition system based on Z80 microprocessor has been developed to monitor and record the engine running hours of terminal tractors in port cargo handling operations. The engine hours data recorded on a large fleet of tractors will be retrieved electronically and later transferred to a personal computer in the office ready to be processed by standard database software package for maintenance planning and scheduling. The implementation of this system thus reduces manpower and time, and climates human error in data handling.

  13. Microprocessor-controlled photovoltaic-array loading unit

    SciTech Connect

    Russell, D.F.

    1982-08-01

    Described is a microprocessor-controlled test system in operation at the Photovoltaics Advanced Systems Test Facility located at Sandia National Laboratories. The test system is designed to measure the total energy output of photovoltaic arrays. The theory, installation, operation, and calibration of the test system are described.

  14. Multiple system atrophy

    MedlinePlus

    ... nervous system that controls important functions such as heart rate, blood pressure, and sweating. ... A pacemaker that is programmed to stimulate the heart to beat at ... blood pressure for some people. Constipation can be treated with ...

  15. Microprocessor Simulation: A Training Technique.

    ERIC Educational Resources Information Center

    Oscarson, David J.

    1982-01-01

    Describes the design and application of a microprocessor simulation using BASIC for formal training of technicians and managers and as a management tool. Illustrates the utility of the modular approach for the instruction and practice of decision-making techniques. (SK)

  16. Controller Chips Preserve Microprocessor Function

    NASA Technical Reports Server (NTRS)

    2012-01-01

    Above the Atlantic Ocean, off the coast of Brazil, there is a dip in the Earth s surrounding magnetic field called the South Atlantic Anomaly. Here, space radiation can reach into Earth s upper atmosphere to interfere with the functioning of satellites, aircraft, and even the International Space Station. "The South Atlantic Anomaly is a hot spot of radiation that the space station goes through at a certain point in orbit," Miria Finckenor, a physicist at Marshall Space Flight Center, describes, "If there s going to be a problem with the electronics, 90 percent of that time, it is going to be in that spot." Space radiation can cause physical damage to microchips and can actually change the software commands in computers. When high-energy particles penetrate a satellite or other spacecraft, the electrical components can absorb the energy and temporarily switch off. If the energy is high enough, it can cause the device to enter a hung state, which can only be addressed by restarting the system. When space radiation affects the operational status of microprocessors, the occurrence is called single event functional interrupt (SEFI). SEFI happens not only to the computers onboard spacecraft in Earth orbit, but to the computers on spacecraft throughout the solar system. "One of the Mars rovers had this problem in the radiation environment and was rebooting itself several times a day. On one occasion, it rebooted 40 times in one day," Finckenor says. "It s hard to obtain any data when you have to constantly reboot and start over."

  17. Low-cost microprocessor controlled shadowband radiometer

    NASA Astrophysics Data System (ADS)

    Michalsky, J. J.; Lebaron, B. A.; Harrison, L. C.

    1985-06-01

    This paper describes the second phase in the development of a low-cost microprocessor-controlled rotating shadowband radiometer at PNL. The initial work, to develop a solar photometer, resulted in a mechanical design that is adopted for the solar radiometer with only minor changes. The goals of this effort are: (1) to improve the data acquisition system; and (2) to derive corrections for the silicon cell-based pyranometer that would allow measurements of total horizontal, diffuse horizontal, and direct normal solar radiation approaching first-class instrumentation accuracy at a fraction of the cost. Significant progress on temperature, cosine and spectral corrections is achieved.

  18. Microprocessor Control of Low Speed VSTOL Flight.

    DTIC Science & Technology

    1979-06-08

    stability augmentation system (SAS) for the AV-8B Advanced Harrier VSTOL aircraft using microprocessor-based digital control. The research focuses on improving the handling qualities of the airplane through SAS redesign in the low speed flight regime. Particular attention is paid to the so-called weather-cocking instability encountered in transition (hover to conventional and vice versa) flight. Until quite recently, there has been a dearth of information about the flight characteristics of the Harrier. A major breakthrough in this field was achieved by the

  19. Microprocessor realizations of range rate filters

    NASA Technical Reports Server (NTRS)

    1979-01-01

    The performance of five digital range rate filters is evaluated. A range rate filter receives an input of range data from a radar unit and produces an output of smoothed range data and its estimated derivative range rate. The filters are compared through simulation on an IBM 370. Two of the filter designs are implemented on a 6800 microprocessor-based system. Comparisons are made on the bases of noise variance reduction ratios and convergence times of the filters in response to simulated range signals.

  20. A microprocessor-controlled CCD star tracker

    NASA Technical Reports Server (NTRS)

    Salomon, P. M.; Goss, W. C.

    1976-01-01

    The STELLAR (Star Tracker for Economical Long Life Attitude Reference) utilizes an image sensing Charge-Coupled Device (CCD) operating under microprocessor control. This approach results in a new type of high-accuracy star tracker which can be adapted to a wide variety of different space flight applications through software changes only. The STELLAR determines two-axis star positions by computing the element and the interelement interpolated centroid positions of the star images. As many as 10 stars may be tracked simultaneously, providing significantly increased stability and accuracy. A detailed description of the STELLAR is presented along with measurements of system performance obtained from an operating breadboard model.

  1. Digital system upset. The effects of simulated lightning-induced transients on a general-purpose microprocessor

    NASA Technical Reports Server (NTRS)

    Belcastro, C. M.

    1983-01-01

    Flight critical computer based control systems designed for advanced aircraft must exhibit ultrareliable performance in lightning charged environments. Digital system upset can occur as a result of lightning induced electrical transients, and a methodology was developed to test specific digital systems for upset susceptibility. Initial upset data indicates that there are several distinct upset modes and that the occurrence of upset is related to the relative synchronization of the transient input with the processing sate of the digital system. A large upset test data base will aid in the formulation and verification of analytical upset reliability modeling techniques which are being developed.

  2. High-speed, automatic controller design considerations for integrating array processor, multi-microprocessor, and host computer system architectures

    NASA Technical Reports Server (NTRS)

    Jacklin, S. A.; Leyland, J. A.; Warmbrodt, W.

    1985-01-01

    Modern control systems must typically perform real-time identification and control, as well as coordinate a host of other activities related to user interaction, online graphics, and file management. This paper discusses five global design considerations which are useful to integrate array processor, multimicroprocessor, and host computer system architectures into versatile, high-speed controllers. Such controllers are capable of very high control throughput, and can maintain constant interaction with the nonreal-time or user environment. As an application example, the architecture of a high-speed, closed-loop controller used to actively control helicopter vibration is briefly discussed. Although this system has been designed for use as the controller for real-time rotorcraft dynamics and control studies in a wind tunnel environment, the controller architecture can generally be applied to a wide range of automatic control applications.

  3. A Microprocessor Control Scheme For Switched Reluctance Motor Drives

    NASA Astrophysics Data System (ADS)

    Oza, A. R.; Krishnan, R.; Adkar, S.

    1987-10-01

    A microprocessor control scheme for a switched reluctance motor(SRM) drive is discussed. A SRM is inherently a variable speed machine since it requires a converter even for constant speed running. Starting with a conceptual development, a particular hardware scheme is discussed for controller implementation. Hardware-software tradeoffs incorporated in the design are discussed. Some results of an actual system are evaluated. It is shown that a microprocessor controller has many advantages over conventional controllers. The controller design uses rotor position and speed feedbacks. Self-starting is incorporated into the design. Use of off-the-shelf components makes the controller simple, reliable, and economical.

  4. Microprocessor controlled transdermal drug delivery.

    PubMed

    Subramony, J Anand; Sharma, Ashutosh; Phipps, J B

    2006-07-06

    Transdermal drug delivery via iontophoresis is reviewed with special focus on the delivery of lidocaine for local anesthesia and fentanyl for patient controlled acute therapy such as postoperative pain. The role of the microprocessor controller in achieving dosimetry, alternating/reverse polarity, pre-programmed, and sensor-based delivery is highlighted. Unique features such as the use of tactile signaling, telemetry control, and pulsatile waveforms in iontophoretic drug delivery are described briefly.

  5. Technology transfer of military space microprocessor developments

    NASA Astrophysics Data System (ADS)

    Gorden, C.; King, D.; Byington, L.; Lanza, D.

    1999-01-01

    Over the past 13 years the Air Force Research Laboratory (AFRL) has led the development of microprocessors and computers for USAF space and strategic missile applications. As a result of these Air Force development programs, advanced computer technology is available for use by civil and commercial space customers as well. The Generic VHSIC Spaceborne Computer (GVSC) program began in 1985 at AFRL to fulfill a deficiency in the availability of space-qualified data and control processors. GVSC developed a radiation hardened multi-chip version of the 16-bit, Mil-Std 1750A microprocessor. The follow-on to GVSC, the Advanced Spaceborne Computer Module (ASCM) program, was initiated by AFRL to establish two industrial sources for complete, radiation-hardened 16-bit and 32-bit computers and microelectronic components. Development of the Control Processor Module (CPM), the first of two ASCM contract phases, concluded in 1994 with the availability of two sources for space-qualified, 16-bit Mil-Std-1750A computers, cards, multi-chip modules, and integrated circuits. The second phase of the program, the Advanced Technology Insertion Module (ATIM), was completed in December 1997. ATIM developed two single board computers based on 32-bit reduced instruction set computer (RISC) processors. GVSC, CPM, and ATIM technologies are flying or baselined into the majority of today's DoD, NASA, and commercial satellite systems.

  6. Multiple pass laser amplifier system

    DOEpatents

    Brueckner, Keith A.; Jorna, Siebe; Moncur, N. Kent

    1977-01-01

    A laser amplification method for increasing the energy extraction efficiency from laser amplifiers while reducing the energy flux that passes through a flux limited system which includes apparatus for decomposing a linearly polarized light beam into multiple components, passing the components through an amplifier in delayed time sequence and recombining the amplified components into an in phase linearly polarized beam.

  7. Small Private Key PKS on an Embedded Microprocessor

    PubMed Central

    Seo, Hwajeong; Kim, Jihyun; Choi, Jongseok; Park, Taehwan; Liu, Zhe; Kim, Howon

    2014-01-01

    Multivariate quadratic ( ) cryptography requires the use of long public and private keys to ensure a sufficient security level, but this is not favorable to embedded systems, which have limited system resources. Recently, various approaches to cryptography using reduced public keys have been studied. As a result of this, at CHES2011 (Cryptographic Hardware and Embedded Systems, 2011), a small public key scheme, was proposed, and its feasible implementation on an embedded microprocessor was reported at CHES2012. However, the implementation of a small private key scheme was not reported. For efficient implementation, random number generators can contribute to reduce the key size, but the cost of using a random number generator is much more complex than computing on modern microprocessors. Therefore, no feasible results have been reported on embedded microprocessors. In this paper, we propose a feasible implementation on embedded microprocessors for a small private key scheme using a pseudo-random number generator and hash function based on a block-cipher exploiting a hardware Advanced Encryption Standard (AES) accelerator. To speed up the performance, we apply various implementation methods, including parallel computation, on-the-fly computation, optimized logarithm representation, vinegar monomials and assembly programming. The proposed method reduces the private key size by about 99.9% and boosts signature generation and verification by 5.78% and 12.19% than previous results in CHES2012. PMID:24651722

  8. Small private key MQPKS on an embedded microprocessor.

    PubMed

    Seo, Hwajeong; Kim, Jihyun; Choi, Jongseok; Park, Taehwan; Liu, Zhe; Kim, Howon

    2014-03-19

    Multivariate quadratic (MQ) cryptography requires the use of long public and private keys to ensure a sufficient security level, but this is not favorable to embedded systems, which have limited system resources. Recently, various approaches to MQ cryptography using reduced public keys have been studied. As a result of this, at CHES2011 (Cryptographic Hardware and Embedded Systems, 2011), a small public key MQ scheme, was proposed, and its feasible implementation on an embedded microprocessor was reported at CHES2012. However, the implementation of a small private key MQ scheme was not reported. For efficient implementation, random number generators can contribute to reduce the key size, but the cost of using a random number generator is much more complex than computing MQ on modern microprocessors. Therefore, no feasible results have been reported on embedded microprocessors. In this paper, we propose a feasible implementation on embedded microprocessors for a small private key MQ scheme using a pseudo-random number generator and hash function based on a block-cipher exploiting a hardware Advanced Encryption Standard (AES) accelerator. To speed up the performance, we apply various implementation methods, including parallel computation, on-the-fly computation, optimized logarithm representation, vinegar monomials and assembly programming. The proposed method reduces the private key size by about 99.9% and boosts signature generation and verification by 5.78% and 12.19% than previous results in CHES2012.

  9. An assembler for the MOS Technology 6502 microprocessor as implemented in jolt (TM) and KIM-1 (TM)

    NASA Technical Reports Server (NTRS)

    Lilley, R. W.

    1976-01-01

    Design of low-cost, microcomputer-based navigation receivers, and the assembler are described. The development of computer software for microprocessors is materially aided by the assembler program using mnemonic variable names. The flexibility of the environment provided by the IBM's Virtual Machine Facility and the Conversational Monitor System, make possible the convenient assembler access. The implementation of the assembler for the microprocessor chip serves a part of the present need and forms a model for support of other microprocessors.

  10. Multiple memory systems as substrates for multiple decision systems.

    PubMed

    Doll, Bradley B; Shohamy, Daphna; Daw, Nathaniel D

    2015-01-01

    It has recently become widely appreciated that value-based decision making is supported by multiple computational strategies. In particular, animal and human behavior in learning tasks appears to include habitual responses described by prominent model-free reinforcement learning (RL) theories, but also more deliberative or goal-directed actions that can be characterized by a different class of theories, model-based RL. The latter theories evaluate actions by using a representation of the contingencies of the task (as with a learned map of a spatial maze), called an "internal model." Given the evidence of behavioral and neural dissociations between these approaches, they are often characterized as dissociable learning systems, though they likely interact and share common mechanisms. In many respects, this division parallels a longstanding dissociation in cognitive neuroscience between multiple memory systems, describing, at the broadest level, separate systems for declarative and procedural learning. Procedural learning has notable parallels with model-free RL: both involve learning of habits and both are known to depend on parts of the striatum. Declarative memory, by contrast, supports memory for single events or episodes and depends on the hippocampus. The hippocampus is thought to support declarative memory by encoding temporal and spatial relations among stimuli and thus is often referred to as a relational memory system. Such relational encoding is likely to play an important role in learning an internal model, the representation that is central to model-based RL. Thus, insofar as the memory systems represent more general-purpose cognitive mechanisms that might subserve performance on many sorts of tasks including decision making, these parallels raise the question whether the multiple decision systems are served by multiple memory systems, such that one dissociation is grounded in the other. Here we investigated the relationship between model-based RL and

  11. Scalable Analysis Techniques for Microprocessor Performance Counter Metrics

    SciTech Connect

    Ahn, D H; Vetter, J S

    2002-07-24

    Contemporary microprocessors provide a rich set of integrated performance counters that allow application developers and system architects alike the opportunity to gather important information about workload behaviors. These counters can capture instruction, memory, and operating system behaviors. Current techniques for analyzing data produced from these counters use raw counts, ratios, and visualization techniques to help users make decisions about their application source code. While these techniques are appropriate for analyzing data from one process, they do not scale easily to new levels demanded by contemporary computing systems. Indeed, the amount of data generated by these experiments is on the order of tens of thousands of data points. Furthermore, if users execute multiple experiments, then we add yet another dimension to this already knotty picture. This flood of multidimensional data can swamp efforts to harvest important ideas from these valuable counters. Very simply, this paper addresses these concerns by evaluating several multivariate statistical techniques on these datasets. We find that several techniques, such as statistical clustering, can automatically extract important features from this data. These derived results can, in turn, be feed directly back to an application developer, or used as input to a more comprehensive performance analysis environment, such as a visualization or an expert system.

  12. MULTIPLE ECH LAUNCHER CONTROL SYSTEM

    SciTech Connect

    GREEN,M.T; PONCE,D; GRUNLOH,H.J; ELLIS,R.A; GROSNICKLE,W.H; HUMPHREY,R.L

    2003-10-01

    OAK-B135 The addition of new, high power gyrotrons to the heating and current drive arsenal at DIII-D, required a system upgrade for control of fully steerable ECH Launchers. Each launcher contains two pointing mirrors with two degrees of mechanical freedom. The two flavors of motion are called facet and tilt. Therefore up to four channels of motion per launcher need to be controlled. The system utilizes absolute encoders to indicate mirror position and therefore direction of the microwave beam. The launcher movement is primarily controlled by PLC, but future iterations of design, may require this control to be accomplished by a CPU on fast bus such as Compact PCI. This will be necessary to accomplish real time position control. Safety of equipment and personnel is of primary importance when controlling a system of moving parts. Therefore multiple interlocks and fault status enunciators have been implemented. This paper addresses the design of a Multiple ECH Launcher Control System, and characterizes the flexibility needed to upgrade to a real time position control system in the future.

  13. Microprocessor Automation of Bipolar Electrocoagulation

    PubMed Central

    L'Huillier, J.P.; Oumerzouk, Y.; Le-Huy, P.; Yvroud, E.; Guillemin, F.; Frisch, R.

    1983-01-01

    The heat produced by high frequency A.C. current, for example 500 KHz modulated by 10 KHz could coagulate proteins and produce hemostasis. Practically this characteristic is used in microsurgery to coagulate vessels hugged between tweezers' tips. The electric and thermic constants of tweezers are being higher than these of tissues, consequently the important temperature elevation on tweezers' tips may cause the carbonization of tissues which are in contact with them. In this paper an analytical model of temperature field in tissues and on the tweezers is described. It takes account of electrical field between the tweezers, and underlines the necessity to regulate their temperature. The knowledge of this physical process allow to elaborate an efficient current loop control drived by microprocessor.

  14. Multiple channel data acquisition system

    SciTech Connect

    Crawley, H. Bert; Rosenberg, Eli I.; Meyer, W. Thomas; Gorbics, Mark S.; Thomas, William D.; McKay, Roy L.; Homer, Jr., John F.

    1990-05-22

    A multiple channel data acquisition system for the transfer of large amounts of data from a multiplicity of data channels has a plurality of modules which operate in parallel to convert analog signals to digital data and transfer that data to a communications host via a FASTBUS. Each module has a plurality of submodules which include a front end buffer (FEB) connected to input circuitry having an analog to digital converter with cache memory for each of a plurality of channels. The submodules are interfaced with the FASTBUS via a FASTBUS coupler which controls a module bus and a module memory. The system is triggered to effect rapid parallel data samplings which are stored to the cache memories. The cache memories are uploaded to the FEBs during which zero suppression occurs. The data in the FEBs is reformatted and compressed by a local processor during transfer to the module memory. The FASTBUS coupler is used by the communications host to upload the compressed and formatted data from the module memory. The local processor executes programs which are downloaded to the module memory through the FASTBUS coupler.

  15. Multiple channel data acquisition system

    SciTech Connect

    Crawley, H.B.; Rosenberg, E.I.; Meyer, W.T.; Gorbics, M.S.; Thomas, W.D.; McKay, R.L.; Homer, J.F. Jr.

    1990-05-22

    A multiple channel data acquisition system for the transfer of large amounts of data from a multiplicity of data channels has a plurality of modules which operate in parallel to convert analog signals to digital data and transfer that data to a communications host via a FASTBUS. Each module has a plurality of submodules which include a front end buffer (FEB) connected to input circuitry having an analog to digital converter with cache memory for each of a plurality of channels. The submodules are interfaced with the FASTBUS via a FASTBUS coupler which controls a module bus and a module memory. The system is triggered to effect rapid parallel data samplings which are stored to the cache memories. The cache memories are uploaded to the FEBs during which zero suppression occurs. The data in the FEBs is reformatted and compressed by a local processor during transfer to the module memory. The FASTBUS coupler is used by the communications host to upload the compressed and formatted data from the module memory. The local processor executes programs which are downloaded to the module memory through the FASTBUS coupler. 25 figs.

  16. A Flight Investigation of Digital Control Using Microprocessor Technology.

    DTIC Science & Technology

    1979-06-01

    DISPLAYS COTOSE IRF MOTIONS I I T EALATIONl PILOT FEPERIANTAL. Figure 3-2. Overview of the VRA/Micro- DFCS System. mechanical linkage connecting to the...April 1979 CELEC T E D 1 .... 3 OCT 23 1980 DISTRIBUTIOD Sor . D : - U Approved for public . Distribution Uniirnitcd - UNC LASS SECURITY CLASSIFICATION...CLASSIFICATION OF Ywl PAGE(IWhen Data Enterod) ABSTRACT A microprocessor-based digital flight control system (Micro- DFCS ) is implemented in Princeton’s

  17. Inventory and Billing Systems for Multiple Users.

    ERIC Educational Resources Information Center

    Frazier, Lavon

    1985-01-01

    Washington State University developed a comprehensive supplies inventory system and a generalized billing system with multiple users in mind. The inventory management system and the service center billing system are described. (Author/MLW)

  18. Models of Multiple System Atrophy

    PubMed Central

    Fellner, Lisa; Wenning, Gregor K.; Stefanova, Nadia

    2016-01-01

    Multiple system atrophy (MSA) is a predominantly sporadic, adult-onset, fatal neurodegenerative disease of unknown etiology. MSA is characterized by autonomic failure, levodopa-unresponsive parkinsonism, cerebellar ataxia and pyramidal signs in any combination. MSA belongs to a group of neurodegenerative disorders termed α-synucleinopathies, which also include Parkinson’s disease and dementia with Lewy bodies. Their common pathological feature is the occurrence of abnormal α-synuclein positive inclusions in neurons or glial cells. In MSA, the main cell type presenting aggregates composed of α-synuclein are oligodendroglial cells. This pathological hallmark, also called glial cytoplasmic inclusions (GCIs), is associated with progressive and profound neuronal loss in various regions of the brain. The development of animal models of MSA is justified by the limited understanding of the mechanisms of neurodegeneration and GCIs formation, which is paralleled by a lack of therapeutic strategies. Two main types of rodent models have been generated to replicate different features of MSA neuropathology. On one hand, neurotoxin-based models have been produced to reproduce neuronal loss in substantia nigra pars compacta and striatum. On the other hand, transgenic mouse models with overexpression of α-synuclein in oligodendroglia have been used to reproduce GCIs-related pathology. This chapter gives an overview of the atypical Parkinson’s syndrome MSA and summarizes the currently available MSA animal models and their relevance for pre-clinical testing of disease-modifying therapies. PMID:24338664

  19. Evolution of a standard microprocessor-based space computer

    NASA Technical Reports Server (NTRS)

    Fernandez, M.

    1980-01-01

    An existing in inventory computer hardware/software package (B-1 RFS/ECM) was repackaged and applied to multiple missile/space programs. Concurrent with the application efforts, low risk modifications were made to the computer from program to program to take advantage of newer, advanced technology and to meet increasingly more demanding requirements (computational and memory capabilities, longer life, and fault tolerant autonomy). It is concluded that microprocessors hold promise in a number of critical areas for future space computer applications. However, the benefits of the DoD VHSIC Program are required and the old proliferation problem must be revised.

  20. Kepler Systems That Show Multiple Transiting Objects

    NASA Astrophysics Data System (ADS)

    Steffen, Jason H.; Fabrycky, D. C.; Ford, E. B.; Holman, M. J.; Lissauer, J. J.; Ragozzine, D.; Welsh, W. F.; Kepler Science Team

    2011-01-01

    Exoplanetary systems that have multiple transiting planets provide unique and important insight into the formation, evolution, and dynamics of exoplanetary systems. Kepler has announced the discovery of a confirmed planetary system with multiple transiting planets (Kepler 9, Holman et al. 2010) as well as several candidate planetary systems that show multiple transiting objects (Steffen et al. 2010). Kepler 9 shows deviations from a constant period due to the ongoing dynamical interactions between the confirmed planets. From these transit timing variations (TTV) one can measure the planetary masses from the photometric data alone. The presence of several systems with multiple transiting candidates from the first quarter of data indicate that Kepler should continue to find systems with multiple transiting planets. Such systems will provide important, general information about the histories of planetary systems.

  1. Using benchmarks for radiation testing of microprocessors and FPGAs

    SciTech Connect

    Quinn, Heather; Robinson, William H.; Rech, Paolo; Aguirre, Miguel; Barnard, Arno; Desogus, Marco; Entrena, Luis; Garcia-Valderas, Mario; Guertin, Steven M.; Kaeli, David; Kastensmidt, Fernanda Lima; Kiddie, Bradley T.; Sanchez-Clemente, Antonio; Reorda, Matteo Sonza; Sterpone, Luca; Wirthlin, Michael

    2015-12-01

    Performance benchmarks have been used over the years to compare different systems. These benchmarks can be useful for researchers trying to determine how changes to the technology, architecture, or compiler affect the system's performance. No such standard exists for systems deployed into high radiation environments, making it difficult to assess whether changes in the fabrication process, circuitry, architecture, or software affect reliability or radiation sensitivity. In this paper, we propose a benchmark suite for high-reliability systems that is designed for field-programmable gate arrays and microprocessors. As a result, we describe the development process and report neutron test data for the hardware and software benchmarks.

  2. A microprocessor-based one dimensional optical data processor for spatial frequency analysis

    NASA Technical Reports Server (NTRS)

    Collier, R. L.; Ballard, G. S.

    1982-01-01

    A high degree of accuracy was obtained in measuring the spatial frequency spectrum of known samples using an optical data processor based on a microprocessor, which reliably collected intensity versus angle data. Stray light control, system alignment, and angle measurement problems were addressed and solved. The capabilities of the instrument were extended by the addition of appropriate optics to allow the use of different wavelengths of laser radiation and by increasing the travel limits of the rotating arm to + or - 160 degrees. The acquisition, storage, and plotting of data by the computer permits the researcher a free hand in data manipulation such as subtracting background scattering from a diffraction pattern. Tests conducted to verify the operation of the processor using a 25 mm diameter pinhole, a 39.37 line pairs per mm series of multiple slits, and a microscope slide coated with 1.091 mm diameter polystyrene latex spheres are described.

  3. Microprocessor utilization in search and rescue missions

    NASA Technical Reports Server (NTRS)

    Schwartz, M.; Bashkow, T.

    1978-01-01

    The position of an emergency transmitter may be determined by measuring the Doppler shift of the distress signal as received by an orbiting satellite. This requires the computation of an initial estimate and refinement of this estimate through an iterative, nonlinear, least squares estimation. A version of the algorithm was implemented and tested by locating a transmitter on the premises and obtaining observations from a satellite. The computer used was an IBM 360/95. The position was determined within the desired 10 km radius accuracy. The feasibility of performing the same task in real time using microprocessor technology, was determined. The least squares algorithm was implemented on an Intel 8080 microprocessor. The results indicate that a microprocessor can easily match the IBM implementation in accuracy and be performed inside the time limitations set.

  4. Microprocessor implementation of an FFT for ionospheric VLF observations

    NASA Technical Reports Server (NTRS)

    Elvidge, J.; Kintner, P.; Holzworth, R.

    1984-01-01

    A fast Fourier transform algorithm is implemented on a CMOS microprocessor for application to very low-frequency electric fields (less than 10 kHz) sensed on high-altitude scientific balloons. Two FFT's are calculated simultaneously by associating them with conjugate symmetric and conjugate antisymmetric results. One goal of the system was to detect spectral signatures associated with fast time variations present in natural signals such as whistlers and chorus. Although a full evaluation of the system was not possible for operational reasons, a measure of the system's success has been defined and evaluated.

  5. Automatic tools for microprocessor failure analysis

    NASA Astrophysics Data System (ADS)

    Conard, Didier; Laurent, J.; Velazco, Raoul; Ziade, Haissam; Cabestany, J.; Sala, F.

    A new approach for fault location when testing microprocessors is presented. The startpoint for the backtracing analysis converging to the failure is constituted by the automatic localization of a reduced area. Automatic image comparison based on pattern recognition is performed by means of an electron beam tester. The developed hardware and software tools allow large circuit areas to be covered offering powerful diagnosis capabilities to the user. The validation of this technique was performed on faulty 68000 microprocessors. It shows the feasibility of the automation of the first and most important step of failure analysis: fault location at the chip surface.

  6. Constructive Multiple-Choice Testing System

    ERIC Educational Resources Information Center

    Park, Jooyong

    2010-01-01

    The newly developed computerized Constructive Multiple-choice Testing system is introduced. The system combines short answer (SA) and multiple-choice (MC) formats by asking examinees to respond to the same question twice, first in the SA format, and then in the MC format. This manipulation was employed to collect information about the two…

  7. Telerobotic management system: coordinating multiple human operators with multiple robots

    NASA Astrophysics Data System (ADS)

    King, Jamie W.; Pretty, Raymond; Brothers, Brendan; Gosine, Raymond G.

    2003-09-01

    This paper describes an application called the Tele-robotic management system (TMS) for coordinating multiple operators with multiple robots for applications such as underground mining. TMS utilizes several graphical interfaces to allow the user to define a partially ordered plan for multiple robots. This plan is then converted to a Petri net for execution and monitoring. TMS uses a distributed framework to allow robots and operators to easily integrate with the applications. This framework allows robots and operators to join the network and advertise their capabilities through services. TMS then decides whether tasks should be dispatched to a robot or a remote operator based on the services offered by the robots and operators.

  8. Single-chip microprocessor that communicates directly using light.

    PubMed

    Sun, Chen; Wade, Mark T; Lee, Yunsup; Orcutt, Jason S; Alloatti, Luca; Georgas, Michael S; Waterman, Andrew S; Shainline, Jeffrey M; Avizienis, Rimas R; Lin, Sen; Moss, Benjamin R; Kumar, Rajesh; Pavanello, Fabio; Atabaki, Amir H; Cook, Henry M; Ou, Albert J; Leu, Jonathan C; Chen, Yu-Hsin; Asanović, Krste; Ram, Rajeev J; Popović, Miloš A; Stojanović, Vladimir M

    2015-12-24

    Data transport across short electrical wires is limited by both bandwidth and power density, which creates a performance bottleneck for semiconductor microchips in modern computer systems--from mobile phones to large-scale data centres. These limitations can be overcome by using optical communications based on chip-scale electronic-photonic systems enabled by silicon-based nanophotonic devices. However, combining electronics and photonics on the same chip has proved challenging, owing to microchip manufacturing conflicts between electronics and photonics. Consequently, current electronic-photonic chips are limited to niche manufacturing processes and include only a few optical devices alongside simple circuits. Here we report an electronic-photonic system on a single chip integrating over 70 million transistors and 850 photonic components that work together to provide logic, memory, and interconnect functions. This system is a realization of a microprocessor that uses on-chip photonic devices to directly communicate with other chips using light. To integrate electronics and photonics at the scale of a microprocessor chip, we adopt a 'zero-change' approach to the integration of photonics. Instead of developing a custom process to enable the fabrication of photonics, which would complicate or eliminate the possibility of integration with state-of-the-art transistors at large scale and at high yield, we design optical devices using a standard microelectronics foundry process that is used for modern microprocessors. This demonstration could represent the beginning of an era of chip-scale electronic-photonic systems with the potential to transform computing system architectures, enabling more powerful computers, from network infrastructure to data centres and supercomputers.

  9. Marine and Human Systems: Addressing Multiple Scales and Multiple Stressors

    NASA Astrophysics Data System (ADS)

    Hofmann, E. E.; Bundy, A.; Chuenpagdee, R.; Maddison, L.; Svendsen, E.

    2015-12-01

    The Integrated Marine Biogeochemistry and Ecosystem Research (IMBER) project aims to develop a comprehensive understanding of, and predictive capacity of ocean responses to accelerating global change and the consequent effects on the Earth System and human society. Understanding the changing ecology and biogeochemistry of marine ecosystems and their sensitivity and resilience to multiple drivers, pressures and stressors is critical to developing responses that will help reduce the vulnerability of marine-dependent human communities. The cumulative pressure of anthropogenic activities on marine systems is already apparent and is projected to increase in the next decades. Policy- and decision-makers need assessments of the status and trends of marine habitats, species, and ecosystems to promote sustainable human activities in the marine environment, particularly in light of global environmental change and changing social systems and human pressures. The IMBER community recently undertook a synthesis and evaluation of approaches for ecosystem-based marine governance, integrated modeling of marine social-ecological systems, and the social and ecological consequences of changing marine ecosystems. The outcomes of this activity provide assessments of current understanding, indicate approaches needed to predict the effects of multiple stressors, at multiple scales, on marine ecosystems and dependent human populations, and highlight approaches for developing innovative societal responses to changing marine ecosystems.

  10. Evolutionary Processes in Multiple Systems

    SciTech Connect

    Eggleton, P P; Kisseleva-Eggleton, L

    2006-02-14

    There are several ways in which triple stars can evolve in somewhat unusual ways. They discuss two situations where Case A Roche-lobe overflow, followed by a merger, can produce anomalous wide binaries such as {gamma} Per; and Kozai cycles in triples with non-parallel orbits, which can produce merged rapidly-rotating stars like AB Dor, and which can also lead to the delayed ejection of one component of a multiple, as may have been observed in T Tau in 1998.

  11. The development of a microprocessor-controlled linearly-actuated valve assembly

    NASA Technical Reports Server (NTRS)

    Wall, R. H.

    1984-01-01

    The development of a proportional fluid control valve assembly is presented. This electromechanical system is needed for space applications to replace the current proportional flow controllers. The flow is controlled by a microprocessor system that monitors the control parameters of upstream pressure and requested volumetric flow rate. The microprocessor achieves the proper valve stem displacement by means of a digital linear actuator. A linear displacement sensor is used to measure the valve stem position. This displacement is monitored by the microprocessor system as a feedback signal to close the control loop. With an upstream pressure between 15 and 47 psig, the developed system operates between 779 standard CU cm/sec (SCCS) and 1543 SCCS.

  12. Single-chip microprocessor that communicates directly using light

    NASA Astrophysics Data System (ADS)

    Sun, Chen; Wade, Mark T.; Lee, Yunsup; Orcutt, Jason S.; Alloatti, Luca; Georgas, Michael S.; Waterman, Andrew S.; Shainline, Jeffrey M.; Avizienis, Rimas R.; Lin, Sen; Moss, Benjamin R.; Kumar, Rajesh; Pavanello, Fabio; Atabaki, Amir H.; Cook, Henry M.; Ou, Albert J.; Leu, Jonathan C.; Chen, Yu-Hsin; Asanović, Krste; Ram, Rajeev J.; Popović, Miloš A.; Stojanović, Vladimir M.

    2015-12-01

    Data transport across short electrical wires is limited by both bandwidth and power density, which creates a performance bottleneck for semiconductor microchips in modern computer systems—from mobile phones to large-scale data centres. These limitations can be overcome by using optical communications based on chip-scale electronic-photonic systems enabled by silicon-based nanophotonic devices8. However, combining electronics and photonics on the same chip has proved challenging, owing to microchip manufacturing conflicts between electronics and photonics. Consequently, current electronic-photonic chips are limited to niche manufacturing processes and include only a few optical devices alongside simple circuits. Here we report an electronic-photonic system on a single chip integrating over 70 million transistors and 850 photonic components that work together to provide logic, memory, and interconnect functions. This system is a realization of a microprocessor that uses on-chip photonic devices to directly communicate with other chips using light. To integrate electronics and photonics at the scale of a microprocessor chip, we adopt a ‘zero-change’ approach to the integration of photonics. Instead of developing a custom process to enable the fabrication of photonics, which would complicate or eliminate the possibility of integration with state-of-the-art transistors at large scale and at high yield, we design optical devices using a standard microelectronics foundry process that is used for modern microprocessors. This demonstration could represent the beginning of an era of chip-scale electronic-photonic systems with the potential to transform computing system architectures, enabling more powerful computers, from network infrastructure to data centres and supercomputers.

  13. Functional Anatomy of the Human Microprocessor.

    PubMed

    Nguyen, Tuan Anh; Jo, Myung Hyun; Choi, Yeon-Gil; Park, Joha; Kwon, S Chul; Hohng, Sungchul; Kim, V Narry; Woo, Jae-Sung

    2015-06-04

    MicroRNA (miRNA) maturation is initiated by Microprocessor composed of RNase III DROSHA and its cofactor DGCR8, whose fidelity is critical for generation of functional miRNAs. To understand how Microprocessor recognizes pri-miRNAs, we here reconstitute human Microprocessor with purified recombinant proteins. We find that Microprocessor is an ∼364 kDa heterotrimeric complex of one DROSHA and two DGCR8 molecules. Together with a 23-amino acid peptide from DGCR8, DROSHA constitutes a minimal functional core. DROSHA serves as a "ruler" by measuring 11 bp from the basal ssRNA-dsRNA junction. DGCR8 interacts with the stem and apical elements through its dsRNA-binding domains and RNA-binding heme domain, respectively, allowing efficient and accurate processing. DROSHA and DGCR8, respectively, recognize the basal UG and apical UGU motifs, which ensure proper orientation of the complex. These findings clarify controversies over the action mechanism of DROSHA and allow us to build a general model for pri-miRNA processing.

  14. Educational Implications of Microelectronics and Microprocessors.

    ERIC Educational Resources Information Center

    Harris, N. D. C., Ed.

    This conference report explores microelectronic technology, its effect on educational methods and objectives, and its implications for educator responsibilities. Two main areas were considered: the significance of the likely impact of the large scale introduction of microprocessors and microelectronics on commercial and industrial processes, the…

  15. VELA: A Microprocessor-Based Laboratory Instrument.

    ERIC Educational Resources Information Center

    Lambert, Andrew

    1983-01-01

    Provides a general description of a preprogramed, microprocessor-based laboratory instrument, discussing its use in monitoring: (1) environmental changes; (2) distribution of count rates from a radioactive source, and (3) motion on an air tract. Includes list of the instrument's various capabilities: frequency meter, voltmeter, interval timer, and…

  16. The Effects of Microprocessors on Industry, Society and Employment: A Meeting of the Frontier Group on Strategies for Change in a Technological Society (Bath, England, March 13, 1979).

    ERIC Educational Resources Information Center

    Harris, N. D. C.

    Discussed are the multiple impacts of microelectronics on society. Included are discussions of the problem of predicting effects, difficulty of exploiting new technology, manpower consequences, and needs within the United Kingdom relating to microprocessors. (RE)

  17. Coed Transactions, Vol. XI, No. 1, January 1979. Microprocessor Course Development Equipment Selection.

    ERIC Educational Resources Information Center

    Mitchell, Eugene E., Ed.; Leventhal, Lance A.

    Many devices and systems related to microprocessors are available on the marketplace. The author suggests that criteria for selecting and designing workstations and development systems are necessary. Seventeen important factors of designing workstations and six desirable features of a development system are presented. The kinds of places in which…

  18. Fast computational scheme of image compression for 32-bit microprocessors

    NASA Technical Reports Server (NTRS)

    Kasperovich, Leonid

    1994-01-01

    This paper presents a new computational scheme of image compression based on the discrete cosine transform (DCT), underlying JPEG and MPEG International Standards. The algorithm for the 2-d DCT computation uses integer operations (register shifts and additions / subtractions only); its computational complexity is about 8 additions per image pixel. As a meaningful example of an on-board image compression application we consider the software implementation of the algorithm for the Mars Rover (Marsokhod, in Russian) imaging system being developed as a part of Mars-96 International Space Project. It's shown that fast software solution for 32-bit microprocessors may compete with the DCT-based image compression hardware.

  19. Microprocessor-controlled laser tracker for atmospheric sensing

    NASA Technical Reports Server (NTRS)

    Johnson, R. A.; Webster, C. R.; Menzies, R. T.

    1985-01-01

    An optical tracking system comprising a visible HeNe laser, an imaging detector, and a microprocessor-controlled mirror, has been designed to track a moving retroreflector located up to 500 m away from an atmospheric instrument and simultaneously direct spectrally tunable infrared laser radiation to the retroreflector for double-ended, long-path absorption measurements of atmospheric species. The tracker has been tested during the recent flight of a balloon-borne tunable diode laser absorption spectrometer which monitors the concentrations of stratospheric species within a volume defined by a 0.14-m-diameter retroreflector lowered 500 m below the instrument gondola.

  20. Modelling microprocessor farms for SSC (Superconducting Super Collider) data acquisition

    SciTech Connect

    Cutts, D.; van Ingen, C.

    1985-01-01

    Data acquisition, involving both data collection and accompanying filtering, is a crucial part of an SSC experiment. The extreme demands on the acquisition system for I/O bandwidth and real-time computation capability that makes irrecoverable event selections requires that the system operation be well designed and fully understood. Modelling is a valuable and perhaps necessary tool for a successful design of such complex systems. As a demonstration of the modelling process we have made a few studies of simple systems consisting of a large number of microprocessors arranged in a ''farm'', a system in which each event is routed from the digitization/readout crates directly to a single microprocessor, one of a large parallel array, which performs the complete software event filter on that event. Subsequent events are transferred in turn to other processor nodes which are idle. The results of our crude simulations agree with the expected performance of such farms, and suggest that realistic modelling of SSC acquisitions will be important. 3 figs.

  1. Inventory and Billing Systems for Multiple Users.

    ERIC Educational Resources Information Center

    Frazier, Lavon

    Washington State University developed a comprehensive supplies inventory system and a generalized billing system with multiple users in mind. The supplies inventory control system developed for Central Stores, a self-sustaining service center that purchases and warehouses office, laboratory, and hardware supplies, was called AIMS, An Inventory…

  2. Hand-held multiple system gas chromatograph

    DOEpatents

    Yu, Conrad M.

    2001-01-01

    A multiple parallel hand-held gas chromatograph (GC) system which includes several independent GCs. Each independent GC has its own injector, separation column, detector and oven and the GCs are mounted in a light weight hand-held assembly. Each GC operates independently and simultaneously. Because of different coatings in different separation columns, different retention times for the same gas will be measured. Thus, for a GC system with multiple parallel GCs, the system can measure, in a short period, different retention times and provide a cross-reference in the determination of the measured gas and to become a two-dimensional system for direct field use.

  3. Hardware math for the 6502 microprocessor

    NASA Technical Reports Server (NTRS)

    Kissel, R.; Currie, J.

    1985-01-01

    A floating-point arithmetic unit is described which is being used in the Ground Facility of Large Space Structures Control Verification (GF/LSSCV). The experiment uses two complete inertial measurement units and a set of three gimbal torquers in a closed loop to control the structural vibrations in a flexible test article (beam). A 6502 (8-bit) microprocessor controls four AMD 9511A floating-point arithmetic units to do all the computation in 20 milliseconds.

  4. Simplified microprocessor design for VLSI control applications

    NASA Technical Reports Server (NTRS)

    Cameron, K.

    1991-01-01

    A design technique for microprocessors combining the simplicity of reduced instruction set computers (RISC's) with the richer instruction sets of complex instruction set computers (CISC's) is presented. They utilize the pipelined instruction decode and datapaths common to RISC's. Instruction invariant data processing sequences which transparently support complex addressing modes permit the formulation of simple control circuitry. Compact implementations are possible since neither complicated controllers nor large register sets are required.

  5. Spacecraft Multiple Array Communication System Performance Analysis

    NASA Technical Reports Server (NTRS)

    Hwu, Shian U.; Desilva, Kanishka; Sham, Catherine C.

    2010-01-01

    The Communication Systems Simulation Laboratory (CSSL) at the NASA Johnson Space Center is tasked to perform spacecraft and ground network communication system simulations, design validation, and performance verification. The CSSL has developed simulation tools that model spacecraft communication systems and the space and ground environment in which the tools operate. In this paper, a spacecraft communication system with multiple arrays is simulated. Multiple array combined technique is used to increase the radio frequency coverage and data rate performance. The technique is to achieve phase coherence among the phased arrays to combine the signals at the targeting receiver constructively. There are many technical challenges in spacecraft integration with a high transmit power communication system. The array combining technique can improve the communication system data rate and coverage performances without increasing the system transmit power requirements. Example simulation results indicate significant performance improvement can be achieved with phase coherence implementation.

  6. NSC 800, 8-bit CMOS microprocessor

    NASA Technical Reports Server (NTRS)

    Suszko, S. F.

    1984-01-01

    The NSC 800 is an 8-bit CMOS microprocessor manufactured by National Semiconductor Corp., Santa Clara, California. The 8-bit microprocessor chip with 40-pad pin-terminals has eight address buffers (A8-A15), eight data address -- I/O buffers (AD(sub 0)-AD(sub 7)), six interrupt controls and sixteen timing controls with a chip clock generator and an 8-bit dynamic RAM refresh circuit. The 22 internal registers have the capability of addressing 64K bytes of memory and 256 I/O devices. The chip is fabricated on N-type (100) silicon using self-aligned polysilicon gates and local oxidation process technology. The chip interconnect consists of four levels: Aluminum, Polysi 2, Polysi 1, and P(+) and N(+) diffusions. The four levels, except for contact interface, are isolated by interlevel oxide. The chip is packaged in a 40-pin dual-in-line (DIP), side brazed, hermetically sealed, ceramic package with a metal lid. The operating voltage for the device is 5 V. It is available in three operating temperature ranges: 0 to +70 C, -40 to +85 C, and -55 to +125 C. Two devices were submitted for product evaluation by F. Stott, MTS, JPL Microprocessor Specialist. The devices were pencil-marked and photographed for identification.

  7. Vibration interaction in a multiple flywheel system

    NASA Astrophysics Data System (ADS)

    Firth, Jordan; Black, Jonathan

    2012-03-01

    This paper investigates vibration interaction in a multiple flywheel system. Flywheels can be used for kinetic energy storage in a satellite Integrated Power and Attitude Control System (IPACS). One hitherto unstudied problem with IPACS is vibration interaction between multiple unbalanced wheels. This paper uses a linear state-space dynamics model to study the impact of vibration interaction. Specifically, imbalance-induced vibration inputs in one flywheel rotor are used to cause a resonant whirling vibration in another rotor. Extra-synchronous resonant vibrations are shown to exist, but with damping modeled the effect is minimal. Vibration is most severe when both rotors are spinning in the same direction.

  8. Programming Languages for Microprocessor Courseware.

    ERIC Educational Resources Information Center

    Schuyler, James A.

    1979-01-01

    Suggests criteria for choosing a programing language in courseware development. Authoring languages (PILOT, TUTOR, BASIC, and PASCAL) are compared; driver programs' compilers and interpreters are discussed; and the tasks of an authoring system are presented. (RAO)

  9. Multiple Fault Isolation in Redundant Systems

    NASA Technical Reports Server (NTRS)

    Pattipati, Krishna R.; Patterson-Hine, Ann; Iverson, David

    1997-01-01

    Fault diagnosis in large-scale systems that are products of modern technology present formidable challenges to manufacturers and users. This is due to large number of failure sources in such systems and the need to quickly isolate and rectify failures with minimal down time. In addition, for fault-tolerant systems and systems with infrequent opportunity for maintenance (e.g., Hubble telescope, space station), the assumption of at most a single fault in the system is unrealistic. In this project, we have developed novel block and sequential diagnostic strategies to isolate multiple faults in the shortest possible time without making the unrealistic single fault assumption.

  10. Multiple Fault Isolation in Redundant Systems

    NASA Technical Reports Server (NTRS)

    Pattipati, Krishna R.

    1997-01-01

    Fault diagnosis in large-scale systems that are products of modem technology present formidable challenges to manufacturers and users. This is due to large number of failure sources in such systems and the need to quickly isolate and rectify failures with minimal down time. In addition, for fault-tolerant systems and systems with infrequent opportunity for maintenance (e.g., Hubble telescope, space station), the assumption of at most a single fault in the system is unrealistic. In this project, we have developed novel block and sequential diagnostic strategies to isolate multiple faults in the shortest possible time without making the unrealistic single fault assumption.

  11. Dynamic characterization and microprocessor control of the NASA/UVA proof mass actuator

    NASA Technical Reports Server (NTRS)

    Zimmerman, D. C.; Inman, D. J.; Horner, G. C.

    1984-01-01

    The self-contained electromagnetic-reaction-type force-actuator system developed by NASA/UVA for the verification of spacecraft-structure vibration-control laws is characterized and demonstrated. The device is controlled by a dedicated microprocessor and has dynamic characteristics determined by Fourier analysis. Test data on a cantilevered beam are shown.

  12. A Cesium Beam Frequency Standard with Microprocessor Control,

    DTIC Science & Technology

    Frequency, *Control, *Symposia, *Electron beams, *Cesium, *Microprocessors, Laboratory tests, Frequency standards, Performance(Engineering), Reliability, Time , State of the art, Computers, Data acquisition

  13. Using benchmarks for radiation testing of microprocessors and FPGAs

    DOE PAGES

    Quinn, Heather; Robinson, William H.; Rech, Paolo; ...

    2015-12-01

    Performance benchmarks have been used over the years to compare different systems. These benchmarks can be useful for researchers trying to determine how changes to the technology, architecture, or compiler affect the system's performance. No such standard exists for systems deployed into high radiation environments, making it difficult to assess whether changes in the fabrication process, circuitry, architecture, or software affect reliability or radiation sensitivity. In this paper, we propose a benchmark suite for high-reliability systems that is designed for field-programmable gate arrays and microprocessors. As a result, we describe the development process and report neutron test data for themore » hardware and software benchmarks.« less

  14. Genetics Home Reference: multiple system atrophy

    MedlinePlus

    ... inability to hold the body upright and balanced (postural instability). The other type of multiple system atrophy , known as MSA-C, is characterized by cerebellar ataxia , which causes problems with coordination and balance. This form of the condition can also include ...

  15. Stress Effects on Multiple Memory System Interactions

    PubMed Central

    Ness, Deborah; Calabrese, Pasquale

    2016-01-01

    Extensive behavioural, pharmacological, and neurological research reports stress effects on mammalian memory processes. While stress effects on memory quantity have been known for decades, the influence of stress on multiple memory systems and their distinct contributions to the learning process have only recently been described. In this paper, after summarizing the fundamental biological aspects of stress/emotional arousal and recapitulating functionally and anatomically distinct memory systems, we review recent animal and human studies exploring the effects of stress on multiple memory systems. Apart from discussing the interaction between distinct memory systems in stressful situations, we will also outline the fundamental role of the amygdala in mediating such stress effects. Additionally, based on the methods applied in the herein discussed studies, we will discuss how memory translates into behaviour. PMID:27034845

  16. 76 FR 39895 - In the Matter of Certain Microprocessors, Components Thereof, and Products Containing Same...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-07

    ... COMMISSION In the Matter of Certain Microprocessors, Components Thereof, and Products Containing Same; Notice... importation, and the sale within the United States after importation of certain microprocessors, components... sale within the United States after importation of certain microprocessors, components thereof,...

  17. A Holter-type microprocessor-based rehabilitation instrument for acquisition and storage of plantar pressure data in children with cerebral palsy.

    PubMed

    Abu-Faraj, Z O; Harris, G F; Abler, J H; Wertsch, J J; Smith, P A

    1996-03-01

    A multichannel, portable data acquisition system has been developed to measure discrete plantar pressures in the rehabilitation of children who have cerebral palsy and planovalgus foot deformity. The microprocessor-based system is designed to be lightweight (350 g with batteries) and portable (no umbilicus) in order to minimize encumbrances to gait patterns. It provides an improved method for obtaining accurate and reliable data during extended recording and rehabilitative periods that is not available from commercial systems. Twelve conductive polymer force (pressure) sensors are used to acquire pressure data, which are then stored in the system memory. Plantar pressures are sampled at a rate of 40 Hz from each of the 12 sensors for up to 2 h. The system consists of 16 analog amplifiers, a 12 b sampling analog-to-digital converter, an 8 b Dallas semiconductor microprocessor (DS5001FP-16, Dallas, TX), 4 MB of pseudo static RAM, and serial and parallel I/O interfaces. The interfaces are used to upload data into a PC for further processing, analysis, and display. During subject testing, sensors are located at predetermined anatomic areas under the calcaneus, medial and lateral midfoot, medial and lateral metatarsal heads, and hallux. Foot pressure data has been acquired from two pediatric subjects during multiple walking trials to illustrate system application in the normal and planovalgus foot. The system is considered to be appropriate for further clinical application and for characterization of event related alterations including rehabilitative, therapeutic, surgical, and nonsurgical treatment.

  18. Establishment of cells to monitor Microprocessor through fusion genes of microRNA and GFP.

    PubMed

    Tsutsui, Motomu; Hasegawa, Hitoki; Adachi, Koichi; Miyata, Maiko; Huang, Peng; Ishiguro, Naoki; Hamaguchi, Michinari; Iwamoto, Takashi

    2008-08-08

    Microprocessor, the complex of Drosha and DGCR8, promotes the processing of primary microRNA to precursor microRNA, which is a crucial step for microRNA maturation. So far, no convenient assay systems have been developed for observing this step in vivo. Here we report the establishment of highly sensitive cellular systems where we can visually monitor the function of Microprocessor. During a series of screening of transfectants with fusion genes of the EGFP cDNA and primary microRNA genes, we have obtained certain cell lines where introduction of siRNA against DGCR8 or Drosha strikingly augments GFP signals. In contrast, these cells have not responded to Dicer siRNA; thus they have a unique character that GFP signals should be negatively and specifically correlated to the action of Microprocessor among biogenesis of microRNA. These cell lines can be useful tools for real-time analysis of Microprocessor action in vivo and identifying its novel modulators.

  19. A Systematic Methodology for Verifying Superscalar Microprocessors

    NASA Technical Reports Server (NTRS)

    Srivas, Mandayam; Hosabettu, Ravi; Gopalakrishnan, Ganesh

    1999-01-01

    We present a systematic approach to decompose and incrementally build the proof of correctness of pipelined microprocessors. The central idea is to construct the abstraction function by using completion functions, one per unfinished instruction, each of which specifies the effect (on the observables) of completing the instruction. In addition to avoiding the term size and case explosion problem that limits the pure flushing approach, our method helps localize errors, and also handles stages with interactive loops. The technique is illustrated on pipelined and superscalar pipelined implementations of a subset of the DLX architecture. It has also been applied to a processor with out-of-order execution.

  20. EnABLing microprocessor for apoptosis.

    PubMed

    Tu, Chi-Chiang; Wang, Jean Y J

    The Microprocessor complex consisting of DROSHA (a type III ribonuclease) and DGCR8 (DiGeorge syndrome critical region gene 8-encoded RNA binding protein) recognizes and cleaves the precursor microRNA hairpin (pre-miRNA) from the primary microRNA transcript (pri-miRNA). The Abelson tyrosine kinase 1 (ABL) phosphorylates DGCR8 to stimulate the cleavage of a subset of pro-apoptotic pri-miRNAs, thus expanding the nuclear functions of ABL to include regulation of RNA processing.

  1. Power electronics for the microprocessor age

    NASA Astrophysics Data System (ADS)

    Kenjo, Takashi

    The design and operation of microprocessor-controlled power electronic drive devices for electrical machines are discussed, with an emphasis on recent advances in controllers for low- and medium-power dc motors. Chapters are devoted to computers, power electronics, and motors; solid-state devices as switch elements; converters and phase controllers; dc converters; servo amplifiers; stepping-motor drive technology; inverters; brushless dc drives; fundamental aspects of converters; and position control using a dc motor. Diagrams, drawings, graphs, photographs, and tables of numerical data are provided.

  2. The immune system--multiple sites but one system.

    PubMed

    Harleman, Johannes H

    2006-07-01

    Recently several guidelines were published on immunotoxicity. Validation studies have shown that detailed extended examination of the immune system is able to flag immunotoxic compounds. Parameters of the examination are presented. In the final examination it is important that the whole immune system is evaluated as one functional system--multiple sites but one system.

  3. Automatic multi-banking of memory for microprocessors

    NASA Technical Reports Server (NTRS)

    Wiker, G. A. (Inventor)

    1984-01-01

    A microprocessor system is provided with added memories to expand its address spaces beyond its address word length capacity by using indirect addressing instructions of a type having a detectable operations code and dedicating designated address spaces of memory to each of the added memories, one space to a memory. By decoding each operations code of instructions read from main memory into a decoder to identify indirect addressing instructions of the specified type, and then decoding the address that follows in a decoder to determine which added memory is associated therewith, the associated added memory is selectively enabled through a unit while the main memory is disabled to permit the instruction to be executed on the location to which the effective address of the indirect address instruction points, either before the indirect address is read from main memory or afterwards, depending on how the system is arranged by a switch.

  4. MPACT Fast Neutron Multiplicity System Prototype Development

    SciTech Connect

    D.L. Chichester; S.A. Pozzi; J.L. Dolan; M.T. Kinlaw; S.J. Thompson; A.C. Kaplan; M. Flaska; A. Enqvist; J.T. Johnson; S.M. Watson

    2013-09-01

    This document serves as both an FY2103 End-of-Year and End-of-Project report on efforts that resulted in the design of a prototype fast neutron multiplicity counter leveraged upon the findings of previous project efforts. The prototype design includes 32 liquid scintillator detectors with cubic volumes 7.62 cm in dimension configured into 4 stacked rings of 8 detectors. Detector signal collection for the system is handled with a pair of Struck Innovative Systeme 16-channel digitizers controlled by in-house developed software with built-in multiplicity analysis algorithms. Initial testing and familiarization of the currently obtained prototype components is underway, however full prototype construction is required for further optimization. Monte Carlo models of the prototype system were performed to estimate die-away and efficiency values. Analysis of these models resulted in the development of a software package capable of determining the effects of nearest-neighbor rejection methods for elimination of detector cross talk. A parameter study was performed using previously developed analytical methods for the estimation of assay mass variance for use as a figure-of-merit for system performance. A software package was developed to automate these calculations and ensure accuracy. The results of the parameter study show that the prototype fast neutron multiplicity counter design is very nearly optimized under the restraints of the parameter space.

  5. Encoding olfactory signals via multiple chemosensory systems.

    PubMed

    Ma, Minghong

    2007-01-01

    Most animals have evolved multiple olfactory systems to detect general odors as well as social cues. The sophistication and interaction of these systems permit precise detection of food, danger, and mates, all crucial elements for survival. In most mammals, the nose contains two well described chemosensory apparatuses (the main olfactory epithelium and the vomeronasal organ), each of which comprises several subtypes of sensory neurons expressing distinct receptors and signal transduction machineries. In many species (e.g., rodents), the nasal cavity also includes two spatially segregated clusters of neurons forming the septal organ of Masera and the Grueneberg ganglion. Results of recent studies suggest that these chemosensory systems perceive diverse but overlapping olfactory cues and that some neurons may even detect the pressure changes carried by the airflow. This review provides an update on how chemosensory neurons transduce chemical (and possibly mechanical) stimuli into electrical signals, and what information each system brings into the brain. Future investigation will focus on the specific ligands that each system detects with a behavioral context and the processing networks that each system involves in the brain. Such studies will lead to a better understanding of how the multiple olfactory systems, acting in concert, offer a complete representation of the chemical world.

  6. Microprocessor-based single particle calibration of scintillation counter

    NASA Technical Reports Server (NTRS)

    Mazumdar, G. K. D.; Pathak, K. M.

    1985-01-01

    A microprocessor-base set-up is fabricated and tested for the single particle calibration of the plastic scintillator. The single particle response of the scintillator is digitized by an A/D converter, and a 8085 A based microprocessor stores the pulse heights. The digitized information is printed. Facilities for CRT display and cassette storing and recalling are also made available.

  7. MIL-STD-1750A Microprocessor Chip Set Development,

    DTIC Science & Technology

    Fairchild ARDL, under contract with General Dynamics/Fort Worth, is developing a high performance MIL- STD -1750A microprocessr chip set for use in...technology. Fairchild MIL- STD -1750A Microprocessor chip set is centered around the F9450A a 20-MHz 64 pin microprocessor with 200ns cycle time that

  8. Information Technologies for the 1980's: Lasers and Microprocessors.

    ERIC Educational Resources Information Center

    Mathews, William D.

    This discussion of the development and application of lasers and microprocessors to information processing stresses laser communication in relation to capacity, reliability, and cost and the advantages of this technology to real-time information access and information storage. The increased capabilities of microprocessors are reviewed, and a…

  9. Microprocessors: An Understandable Guide for the Classroom Teacher.

    ERIC Educational Resources Information Center

    Okinaka, Russell T.

    A microprocessor constitutes the heart and soul of a personal computer. Indeed, the quality of a personal computer is determined largely by the type of microprocessor that is included within its circuitry. Since the microcomputer revolution began in the late 1970s, these special chips have gone through a series of improvements and modifications.…

  10. Microprocessor-controlled, wide-range streak camera

    SciTech Connect

    Amy E. Lewis, Craig Hollabaugh

    2006-09-01

    Bechtel Nevada/NSTec recently announced deployment of their fifth generation streak camera. This camera incorporates many advanced features beyond those currently available for streak cameras. The arc-resistant driver includes a trigger lockout mechanism, actively monitors input trigger levels, and incorporates a high-voltage fault interrupter for user safety and tube protection. The camera is completely modular and may deflect over a variable full-sweep time of 15 nanoseconds to 500 microseconds. The camera design is compatible with both large- and small-format commercial tubes from several vendors. The embedded microprocessor offers Ethernet connectivity, and XML [extensible markup language]-based configuration management with non-volatile parameter storage using flash-based storage media. The camera’s user interface is platform-independent (Microsoft Windows, Unix, Linux, Macintosh OSX) and is accessible using an AJAX [asynchronous Javascript and XML]-equipped modem browser, such as Internet Explorer 6, Firefox, or Safari. User interface operation requires no installation of client software or browser plug-in technology. Automation software can also access the camera configuration and control using HTTP [hypertext transfer protocol]. The software architecture supports multiple-simultaneous clients, multiple cameras, and multiple module access with a standard browser. The entire user interface can be customized.

  11. Microprocessor-controlled wide-range streak camera

    NASA Astrophysics Data System (ADS)

    Lewis, Amy E.; Hollabaugh, Craig

    2006-08-01

    Bechtel Nevada/NSTec recently announced deployment of their fifth generation streak camera. This camera incorporates many advanced features beyond those currently available for streak cameras. The arc-resistant driver includes a trigger lockout mechanism, actively monitors input trigger levels, and incorporates a high-voltage fault interrupter for user safety and tube protection. The camera is completely modular and may deflect over a variable full-sweep time of 15 nanoseconds to 500 microseconds. The camera design is compatible with both large- and small-format commercial tubes from several vendors. The embedded microprocessor offers Ethernet connectivity, and XML [extensible markup language]-based configuration management with non-volatile parameter storage using flash-based storage media. The camera's user interface is platform-independent (Microsoft Windows, Unix, Linux, Macintosh OSX) and is accessible using an AJAX [asynchronous Javascript and XML]-equipped modem browser, such as Internet Explorer 6, Firefox, or Safari. User interface operation requires no installation of client software or browser plug-in technology. Automation software can also access the camera configuration and control using HTTP [hypertext transfer protocol]. The software architecture supports multiple-simultaneous clients, multiple cameras, and multiple module access with a standard browser. The entire user interface can be customized.

  12. Multiple energy synchrotron biomedical imaging system

    NASA Astrophysics Data System (ADS)

    Bassey, B.; Martinson, M.; Samadi, N.; Belev, G.; Karanfil, C.; Qi, P.; Chapman, D.

    2016-12-01

    A multiple energy imaging system that can extract multiple endogenous or induced contrast materials as well as water and bone images would be ideal for imaging of biological subjects. The continuous spectrum available from synchrotron light facilities provides a nearly perfect source for multiple energy x-ray imaging. A novel multiple energy x-ray imaging system, which prepares a horizontally focused polychromatic x-ray beam, has been developed at the BioMedical Imaging and Therapy bend magnet beamline at the Canadian Light Source. The imaging system is made up of a cylindrically bent Laue single silicon (5,1,1) crystal monochromator, scanning and positioning stages for the subjects, flat panel (area) detector, and a data acquisition and control system. Depending on the crystal’s bent radius, reflection type, and the horizontal beam width of the filtered synchrotron radiation (20-50 keV) used, the size and spectral energy range of the focused beam prepared varied. For example, with a bent radius of 95 cm, a (1,1,1) type reflection and a 50 mm wide beam, a 0.5 mm wide focused beam of spectral energy range 27 keV-43 keV was obtained. This spectral energy range covers the K-edges of iodine (33.17 keV), xenon (34.56 keV), cesium (35.99 keV), and barium (37.44 keV) some of these elements are used as biomedical and clinical contrast agents. Using the developed imaging system, a test subject composed of iodine, xenon, cesium, and barium along with water and bone were imaged and their projected concentrations successfully extracted. The estimated dose rate to test subjects imaged at a ring current of 200 mA is 8.7 mGy s-1, corresponding to a cumulative dose of 1.3 Gy and a dose of 26.1 mGy per image. Potential biomedical applications of the imaging system will include projection imaging that requires any of the extracted elements as a contrast agent and multi-contrast K-edge imaging.

  13. Iontophoretic Transport Across a Multiple Membrane System

    PubMed Central

    MOLOKHIA, SARAH A.; ZHANG, YANHUI; HIGUCHI, WILLIAM I.; LI, S. KEVIN

    2008-01-01

    The objective of the present study was to investigate the iontophoretic transport behavior across multiple membranes of different barrier properties. Spectra/Por® (SP) and Ionac membranes were the synthetic membranes and sclera was the biomembrane in this model study. The barrier properties of SP membranes were determined individually in passive and iontophoresis transport experiments with tetraethylammonium ion (TEA), chloride ion (Cl), and mannitol as the model permeants. Passive and iontophoretic transport experiments were then conducted with an assembly of SP membranes. The contribution of electroosmosis to iontophoresis was assessed using the mannitol data. Model analysis was performed to study the contribution of diffusion and electromigration to electrotransport across the multiple membrane system. The effects of membrane barrier thickness upon ion-exchange membrane-enhanced iontophoresis were examined with Ionac, SP, and sclera. The present study shows that iontophoretic transport of TEA across the membrane system was related to the thicknesses and permeability coefficients of the membranes and the electromobilities of the permeant across the individual membranes in the assembly. Model analysis suggests significant contribution of diffusion within the membranes across the membrane system, and this mechanism is relatively independent of the current density applied across the system in iontophoresis dominant transport. PMID:17990310

  14. The labeled systems of multiple neural networks.

    PubMed

    Nemissi, M; Seridi, H; Akdag, H

    2008-08-01

    This paper proposes an implementation scheme of K-class classification problem using systems of multiple neural networks. Usually, a multi-class problem is decomposed into simple sub-problems solved independently using similar single neural networks. For the reason that these sub-problems are not equivalent in their complexity, we propose a system that includes reinforced networks destined to solve complicated parts of the entire problem. Our approach is inspired from principles of the multi-classifiers systems and the labeled classification, which aims to improve performances of the networks trained by the Back-Propagation algorithm. We propose two implementation schemes based on both OAO (one-against-all) and OAA (one-against-one). The proposed models are evaluated using iris and human thigh databases.

  15. Multiple weapon system distributed sensor concept

    NASA Astrophysics Data System (ADS)

    Rafailov, Michael K.

    2009-05-01

    Distributed Sensor Concept-DISCO was proposed for multiplication of individual weapon capability through cooperative target engagement. DISCO creates practically distributed in space sensor network that performs sensing by exchanging of pre-track frame and GNC data. Concept of operations for DISCO is based on complete absence of any kind of host vehicle with its weight allocated for unique and costly propulsion, communication and avionics, and, in the same time DISCO preserves the original idea of multiplicity of lightweight effective weapon dispensed from an unitary payload Three major benefits of DISCO are: immediate PBO deployment; absence of any kind of carrier or "central" vehicle or bus; multiplicity of weapon. DISCO sensor network supports target handover without active ranging but by triangulating. Digital video-signal processing that supports DISCO is Recursive Adaptive Frame Integration of Limited data. Each sensor disseminates to and receives frame, calibration and GNC data from other sensors in the network. In this paper efficiency of DISCO weapon system is discussed for acquisition, accurate handover and track correlation.

  16. [Susceptibility gene in multiple system atrophy (MSA)].

    PubMed

    Tsuji, Shoji

    2014-01-01

    To elucidate molecular bases of multiple system atrophy (MSA), we first focused on recently identified MSA multiplex families. Though linkage analyses followed by whole genome resequencing, we have identified a causative gene, COQ2, for MSA. We then conducted comprehensive nucleotide sequence analysis of COQ2 of sporadic MSA cases and controls, and found that functionally deleterious COQ2 variants confer a strong risk for developing MSA. COQ2 encodes an enzyme in the biosynthetic pathway of coenzyme Q10. Decreased synthesis of coenzyme Q10 is considered to be involved in the pathogenesis of MSA through decreased electron transport in mitochondria and increased vulnerability to oxidative stress.

  17. Low cost design of microprocessor EDAC circuit

    NASA Astrophysics Data System (ADS)

    Li, Hao; Lixin, Yu; Heping, Peng; Wei, Zhuang

    2015-11-01

    An optimization method of error detection and correction (EDAC) circuit design is proposed. The method involves selecting or constructing EDAC codes of low cost hardware, associated with operation scheduling implementation based on 2-input XOR gates structure, and two actions for reducing hardware cells, which can reduce the delay penalties and area costs of the EDAC circuit effectively. The 32-bit EDAC circuit hardware implementation is selected to make a prototype, based on the 180 nm process. The delay penalties and area costs of the EDAC circuit are evaluated. Results show that the time penalty and area cost of the EDAC circuitries are affected with different parity-check matrices and different hardware implementation for the EDAC codes with the same capability of correction and detection code. This method can be used as a guide for low-cost radiation-hardened microprocessor EDAC circuit design and for more advanced technologies.

  18. Application of Microprocessor-Based Equipment in Nuclear Power Plants - Technical Basis for a Qualification Methodology

    SciTech Connect

    Korsah, K.

    2001-08-24

    This document (1) summarizes the most significant findings of the ''Qualification of Advanced Instrumentation and Control (I&C) Systems'' program initiated by the Nuclear Regulatory Commission (NRC); (2) documents a comparative analysis of U.S. and European qualification standards; and (3) provides recommendations for enhancing regulatory guidance for environmental qualification of microprocessor-based safety-related systems. Safety-related I&C system upgrades of present-day nuclear power plants, as well as I&C systems of Advanced Light-Water Reactors (ALWRs), are expected to make increasing use of microprocessor-based technology. The Nuclear Regulatory Commission (NRC) recognized that the use of such technology may pose environmental qualification challenges different from current, analog-based I&C systems. Hence, it initiated the ''Qualification of Advanced Instrumentation and Control Systems'' program. The objectives of this confirmatory research project are to (1) identify any unique environmental-stress-related failure modes posed by digital technologies and their potential impact on the safety systems and (2) develop the technical basis for regulatory guidance using these findings. Previous findings from this study have been documented in several technical reports. This final report in the series documents a comparative analysis of two environmental qualification standards--Institute of Electrical and Electronics Engineers (IEEE) Std 323-1983 and International Electrotechnical Commission (IEC) 60780 (1998)--and provides recommendations for environmental qualification of microprocessor-based systems based on this analysis as well as on the findings documented in the previous reports. The two standards were chosen for this analysis because IEEE 323 is the standard used in the U.S. for the qualification of safety-related equipment in nuclear power plants, and IEC 60780 is its European counterpart. In addition, the IEC document was published in 1998, and should

  19. Proceedings: DISE Workshop on Microprocessors and Education (Fort Collins, Colorado, August 16-18, 1976).

    ERIC Educational Resources Information Center

    Pittsburgh Univ., PA. Dept. of Electrical Engineering.

    Papers presented during four sessions of a workshop, which addressed the role of microprocessors in education, are included in this publication. The issues covered involved seven areas: (1) views of the microelectronics industry; (2) microprocessor architecture; (3) microprocessor chip design; (4) microprocessor software; (5) the impact of…

  20. In vitro models of multiple system atrophy.

    PubMed

    Stefanova, Nadia; Reindl, Markus; Poewe, Werner; Wenning, Gregor K

    2005-08-01

    alpha-Synuclein represents the major constituent of oligodendroglial cytoplasmic inclusions, the hallmark lesion of multiple system atrophy (MSA), a progressive disorder that is associated with selective degenerative cell loss in basal ganglia, cerebellum, brainstem, and spinal cord. The role of abnormal alpha-synuclein aggregation in oligodendroglial cells is still obscure, in particular, whether alpha-synuclein might impair oligodendroglial and, secondarily, neuronal integrity of those cells in the diseased brain. In an attempt to answer some of these questions, we have developed an "in vitro model of MSA" by expressing the wild-type or C-terminally truncated form of alpha-synuclein in glial cell cultures. With this simplified system, we have demonstrated that alpha-synuclein significantly affects the survival of glia and its vulnerability to environmental stress, which might represent a major step in the pathogenesis of MSA.

  1. Multiple beam antenna/switch system study

    NASA Technical Reports Server (NTRS)

    1989-01-01

    In the study of the Multiple Beam Antenna/Switch for the space to ground link (SGL) uplink and downlink services, several issues related to system engineering, antenna, transmit/receive, and switch systems were addressed and the results are provided. Bandwidth allocation at Ku band is inadequate to serve the data rate requirements for the forward and return services. Rain and depolarization effects at EHF, especially at Ka band, pose a significant threat to the link availabilities at heavy rain areas. Hardware induced effects such as the nonlinear characteristics of the power amplifier may necessitate the use of linearizers and limiters. It is also important to identify the components that are susceptible to the space radiation effects and shield or redesign them with rad-hard technologies for meeting the requirements of the space environment.

  2. Multiple beam laser cell micropatterning system

    NASA Astrophysics Data System (ADS)

    Narasimhan, Sriram V.; Goodwin, Richard L.; Borg, Thomas K.; Dawson, Darren M.; Gao, Bruce Z.

    2004-10-01

    The various cell mechanisms, including cell-cell interactions, in native tissue could be better understood by engineering a cell coculture with a micro environment that closely mimics the natural cell arrangement. To this end, we developed a cell micropatterning system that uses a weakly focused laser beam to trap individual cells at the center of the beam and propel them forward onto an appropriate substrate. The optimal methods of introducing different cell types to be patterned into the patterning system and preventing cells from randomly falling onto the pattern were issues to be addressed with this system. Here, we report the development of a multi-chamber, multi-beam laser cell micropatterning system, in which the delivery of specific cells into the beam can be controlled using secondary laser beams. This permits consecutive creation of a pattern involving multiple cell types at specific relative positions. As examples, various patterns of fibroblasts have been created on collagen coated coverslips. In addition, two asynchronously beating clusters of cardiomyocytes were connected with fibroblasts of cardiac origin, yielding a deeper insight into the electrophysiological role of fibroblasts in conduction of the action potentials among cardiomyocytes.

  3. MPACT Fast Neutron Multiplicity System Design Concepts

    SciTech Connect

    D. L. Chichester; S. A. Pozzi; J. L. Dolan; M. T. Kinlaw; A. C. Kaplan; M. Flaska; A. Enqvist; J. T. Johnsom; S. M. Watson

    2012-10-01

    This report documents work performed by Idaho National Laboratory and the University of Michigan in fiscal year (FY) 2012 to examine design parameters related to the use of fast-neutron multiplicity counting for assaying plutonium for materials protection, accountancy, and control purposes. This project seeks to develop a new type of neutron-measurement-based plutonium assay instrument suited for assaying advanced fuel cycle materials. Some current-concept advanced fuels contain high concentrations of plutonium; some of these concept fuels also contain other fissionable actinides besides plutonium. Because of these attributes the neutron emission rates of these new fuels may be much higher, and more difficult to interpret, than measurements made of plutonium-only materials. Fast neutron multiplicity analysis is one approach for assaying these advanced nuclear fuels. Studies have been performed to assess the conceptual performance capabilities of a fast-neutron multiplicity counter for assaying plutonium. Comparisons have been made to evaluate the potential improvements and benefits of fast-neutron multiplicity analyses versus traditional thermal-neutron counting systems. Fast-neutron instrumentation, using for example an array of liquid scintillators such as EJ-309, have the potential to either a) significantly reduce assay measurement times versus traditional approaches, for comparable measurement precision values, b) significantly improve assay precision values, for measurement durations comparable to current-generation technology, or c) moderating improve both measurement precision and measurement durations versus current-generation technology. Using the MCNPX-PoliMi Monte Carlo simulation code, studies have been performed to assess the doubles-detection efficiency for a variety of counter layouts of cylindrical liquid scintillator detector cells over one, two, and three rows. Ignoring other considerations, the best detector design is the one with the most

  4. The Microprocessor controls the activity of mammalian retrotransposons.

    PubMed

    Heras, Sara R; Macias, Sara; Plass, Mireya; Fernandez, Noemí; Cano, David; Eyras, Eduardo; Garcia-Perez, José L; Cáceres, Javier F

    2013-10-01

    More than half of the human genome is made of transposable elements whose ongoing mobilization is a driving force in genetic diversity; however, little is known about how the host regulates their activity. Here, we show that the Microprocessor (Drosha-DGCR8), which is required for microRNA biogenesis, also recognizes and binds RNAs derived from human long interspersed element 1 (LINE-1), Alu and SVA retrotransposons. Expression analyses demonstrate that cells lacking a functional Microprocessor accumulate LINE-1 mRNA and encoded proteins. Furthermore, we show that structured regions of the LINE-1 mRNA can be cleaved in vitro by Drosha. Additionally, we used a cell culture-based assay to show that the Microprocessor negatively regulates LINE-1 and Alu retrotransposition in vivo. Altogether, these data reveal a new role for the Microprocessor as a post-transcriptional repressor of mammalian retrotransposons and a defender of human genome integrity.

  5. A programmable controller based on CAN field bus embedded microprocessor and FPGA

    NASA Astrophysics Data System (ADS)

    Cai, Qizhong; Guo, Yifeng; Chen, Wenhei; Wang, Mingtao

    2008-10-01

    One kind of new programmable controller(PLC) is introduced in this paper. The advanced embedded microprocessor and Field-Programmable Gate Array (FPGA) device are applied in the PLC system. The PLC system structure was presented in this paper. It includes 32 bits Advanced RISC Machines (ARM) embedded microprocessor as control core, FPGA as control arithmetic coprocessor and CAN bus as data communication criteria protocol connected the host controller and its various extension modules. It is detailed given that the circuits and working principle, IiO interface circuit between ARM and FPGA and interface circuit between ARM and FPGA coprocessor. Furthermore the interface circuit diagrams between various modules are written. In addition, it is introduced that ladder chart program how to control the transfer info of control arithmetic part in FPGA coprocessor. The PLC, through nearly two months of operation to meet the design of the basic requirements.

  6. A case study for the real-time experimental evaluation of the VIPER microprocessor

    NASA Technical Reports Server (NTRS)

    Carreno, Victor A.; Angellatta, Rob K.

    1991-01-01

    An experiment to evaluate the applicability of the Verifiable Integrated Processor for Enhanced Reliability (VIPER) microprocessor to real time control is described. The VIPER microprocessor was invented by the Royal Signals and Radar Establishment (RSRE), U.K., and is an example of the use of formal mathematical methods for developing electronic digital systems with a high degree of assurance on the system design and implementation correctness. The experiment consisted of selecting a control law, writing the control law algorithm for the VIPER processor, and providing real time, dynamic inputs into the processor and monitoring the outputs. The control law selected and coded for the VIPER processor was the yaw damper function of an automatic landing program for a 737 aircraft. The mechanisms for interfacing the VIPER Single Board Computer to the VAX host are described. Results include run time experiences, performance evaluation, and comparison of VIPER and FORTRAN yaw damper algorithm output for accuracy estimation.

  7. A case study for the real-time experimental evaluation of the VIPER microprocessor

    NASA Astrophysics Data System (ADS)

    Carreno, Victor A.; Angellatta, Rob K.

    1991-09-01

    An experiment to evaluate the applicability of the Verifiable Integrated Processor for Enhanced Reliability (VIPER) microprocessor to real time control is described. The VIPER microprocessor was invented by the Royal Signals and Radar Establishment (RSRE), U.K., and is an example of the use of formal mathematical methods for developing electronic digital systems with a high degree of assurance on the system design and implementation correctness. The experiment consisted of selecting a control law, writing the control law algorithm for the VIPER processor, and providing real time, dynamic inputs into the processor and monitoring the outputs. The control law selected and coded for the VIPER processor was the yaw damper function of an automatic landing program for a 737 aircraft. The mechanisms for interfacing the VIPER Single Board Computer to the VAX host are described. Results include run time experiences, performance evaluation, and comparison of VIPER and FORTRAN yaw damper algorithm output for accuracy estimation.

  8. Microprocessor control and networking for the amps breadboard

    NASA Technical Reports Server (NTRS)

    Floyd, Stephen A.

    1987-01-01

    Future space missions will require more sophisticated power systems, implying higher costs and more extensive crew and ground support involvement. To decrease this human involvement, as well as to protect and most efficiently utilize this important resource, NASA has undertaken major efforts to promote progress in the design and development of autonomously managed power systems. Two areas being actively pursued are autonomous power system (APS) breadboards and knowledge-based expert system (KBES) applications. The former are viewed as a requirement for the timely development of the latter. Not only will they serve as final testbeds for the various KBES applications, but will play a major role in the knowledge engineering phase of their development. The current power system breadboard designs are of a distributed microprocessor nature. The distributed nature, plus the need to connect various external computer capabilities (i.e., conventional host computers and symbolic processors), places major emphasis on effective networking. The communications and networking technologies for the first power system breadboard/test facility are described.

  9. Disintegrating Multiple Systems in Early Stellar Evolution

    NASA Astrophysics Data System (ADS)

    Reipurth, Bo

    2000-12-01

    An analysis of the multiplicity of 14 sources driving giant Herbig-Haro flows has revealed an observed binary frequency between 79% and 86%, of which half are higher order multiples. These sources represent the hitherto youngest sample of stars examined for binarity. I postulate that the dynamical decay of triple or multiple systems leads to strong outflow activity. It is well known that a large fraction of nonhierarchical triple systems rapidly break up and eject the lightest member. At the same time a closer binary in a highly eccentric orbit is formed. Massive disk truncation results, accompanied by large-scale accretion, with a consequent burst of outflow activity, which produces the observed giant HH bow shocks. Some of the material culled from the individual circumstellar disks may settle into a circumbinary disk around the newly bound stellar pair. The small remaining and truncated circumstellar disks are fed from the circumbinary disk through gas streams, and this as well as other dynamical effects cause the binary orbit to shrink. Gas streams together with disk interactions at periastron drive cyclic accretion modulated on an orbital timescale. As the stellar components gradually spiral toward each other, the increasingly frequent mass-loss events form chains of HH objects until eventually the binary has a semimajor axis of only 9-12 AU, at which point the closely spaced shocked ejecta appear as a finely collimated jet. Thus, such HH flows can be read as a fossil record of the evolution of orbital motions of a binary, newly formed in a triple disintegration event, as it shrinks from a typical separation of 100 AU or more to 10 AU or less. When the triple system disintegrates and a single star is ejected, the newly formed binary recoils, and as a result both components (star and close binary) leave their nascent envelope. While one component becomes visible as a T Tauri star, the other will be obscured for a while by the envelope and will appear as a bright

  10. Test report for single event effects of the 80386DX microprocessor

    NASA Technical Reports Server (NTRS)

    Watson, R. Kevin; Schwartz, Harvey R.; Nichols, Donald K.

    1993-01-01

    The Jet Propulsion Laboratory Section 514 Single Event Effects (SEE) Testing and Analysis Group has performed a series of SEE tests of certain strategic registers of Intel's 80386DX CHMOS 4 microprocessor. Following a summary of the test techniques and hardware used to gather the data, we present the SEE heavy ion and proton test results. We also describe the registers tested, along with a system impact analysis should these registers experience a single event upset.

  11. Quantized levitation states of superconducting multiple-ring systems

    SciTech Connect

    Haley, S.B.; Fink, H.J.

    1996-02-01

    The quantized levitation, trapped, and suspension states of a magnetic microsphere held in equilibrium by two fixed superconducting (SC) microrings are calculated by minimizing the free energy of the system. Each state is a discrete function of two independent fluxoid quantum numbers of the rings. When the radii of the SC rings are of the same order as the Ginzburg-Landau coherence length {xi}({ital T}), the system exhibits a small set of gravity and temperature-dependent levels. The levels of a weakly magnetized particle are sensitive functions of the gravitational field, indicating potential application as an accelerometer, and for trapping small magnetic particles in outer space or on Earth. The equilibrium states of a SC ring levitated by another SC ring are also calculated. {copyright} {ital 1996 The American Physical Society.}

  12. Probabilistic deployment for multiple sensor systems

    NASA Astrophysics Data System (ADS)

    Qian, Ming; Ferrari, Silvia

    2005-05-01

    The performance of many multi-sensor systems can be significantly improved by using a priori environmental information and sensor data to plan the movements of sensor platforms that are later deployed with the purpose of improving the quality of the final detection and classification results. However, existing path planning algorithms and ad-hoc data processing (e.g., fusion) techniques do not allow for the systematic treatment of multiple and heterogeneous sensors and their platforms. This paper presents a method that combines Bayesian network inference with probabilistic roadmap (PRM) planners to utilize the information obtained by different sensors and their level of uncertainty. The uncertainty of prior sensed information is represented by entropy values obtained from the Bayesian network (BN) models of the respective sensor measurement processes. The PRM algorithm is modified to utilize the entropy distribution in optimizing the path of posterior sensor platforms that have the following objectives: (1) improve the quality of the sensed information, i.e., through fusion, (2) minimize the distance traveled by the platforms, and (3) avoid obstacles. This so-called Probabilistic Deployment (PD) method is applied to a demining system comprised of ground-penetrating radars (GPR), electromagnetic (EMI), and infrared sensors (IR) installed on ground platforms, to detect and classify buried mines. Numerical simulations show that PD is more efficient than path planning techniques that do not utilize a priori information, such as complete coverage, random coverage method, or PRM methods that do not utilize Bayesian inference.

  13. The Challenge of Multiple Perspectives: Multiple Solution Tasks for Students Incorporating Diverse Tools and Representation Systems

    ERIC Educational Resources Information Center

    Kordaki, Maria

    2015-01-01

    This study focuses on the role of multiple solution tasks (MST) incorporating multiple learning tools and representation systems (MTRS) in encouraging each student to develop multiple perspectives on the learning concepts under study and creativity of thought. Specifically, two types of MST were used, namely tasks that allowed and demanded…

  14. Optical detector calibrator system

    NASA Technical Reports Server (NTRS)

    Strobel, James P. (Inventor); Moerk, John S. (Inventor); Youngquist, Robert C. (Inventor)

    1996-01-01

    An optical detector calibrator system simulates a source of optical radiation to which a detector to be calibrated is responsive. A light source selected to emit radiation in a range of wavelengths corresponding to the spectral signature of the source is disposed within a housing containing a microprocessor for controlling the light source and other system elements. An adjustable iris and a multiple aperture filter wheel are provided for controlling the intensity of radiation emitted from the housing by the light source to adjust the simulated distance between the light source and the detector to be calibrated. The geared iris has an aperture whose size is adjustable by means of a first stepper motor controlled by the microprocessor. The multiple aperture filter wheel contains neutral density filters of different attenuation levels which are selectively positioned in the path of the emitted radiation by a second stepper motor that is also controlled by the microprocessor. An operator can select a number of detector tests including range, maximum and minimum sensitivity, and basic functionality. During the range test, the geared iris and filter wheel are repeatedly adjusted by the microprocessor as necessary to simulate an incrementally increasing simulated source distance. A light source calibration subsystem is incorporated in the system which insures that the intensity of the light source is maintained at a constant level over time.

  15. TDP-43 regulates the microprocessor complex activity during in vitro neuronal differentiation.

    PubMed

    Di Carlo, Valerio; Grossi, Elena; Laneve, Pietro; Morlando, Mariangela; Dini Modigliani, Stefano; Ballarino, Monica; Bozzoni, Irene; Caffarelli, Elisa

    2013-12-01

    TDP-43 (TAR DNA-binding protein 43) is an RNA-binding protein implicated in RNA metabolism at several levels. Even if ubiquitously expressed, it is considered as a neuronal activity-responsive factor and a major signature for neurological pathologies, making the comprehension of its activity in the nervous system a very challenging issue. TDP-43 has also been described as an accessory component of the Drosha-DGCR8 (DiGeorge syndrome critical region gene 8) microprocessor complex, which is crucially involved in basal and tissue-specific RNA processing events. In the present study, we exploited in vitro neuronal differentiation systems to investigate the TDP-43 demand for the microprocessor function, focusing on both its canonical microRNA biosynthetic activity and its alternative role as a post-transcriptional regulator of gene expression. Our findings reveal a novel role for TDP-43 as an essential factor that controls the stability of Drosha protein during neuronal differentiation, thus globally affecting the production of microRNAs. We also demonstrate that TDP-43 is required for the Drosha-mediated regulation of Neurogenin 2, a master gene orchestrating neurogenesis, whereas post-transcriptional control of Dgcr8, another Drosha target, resulted to be TDP-43-independent. These results implicate a previously uncovered contribution of TDP-43 in regulating the abundance and the substrate specificity of the microprocessor complex and provide new insights into TDP-43 as a key player in neuronal differentiation.

  16. Dynamical modelling of coordinated multiple robot systems

    NASA Technical Reports Server (NTRS)

    Hayati, Samad

    1987-01-01

    The state of the art in the modeling of the dynamics of coordinated multiple robot manipulators is summarized and various problems related to this subject are discussed. It is recognized that dynamics modeling is a component used in the design of controllers for multiple cooperating robots. As such, the discussion addresses some problems related to the control of multiple robots. The techniques used to date in the modeling of closed kinematic chains are summarized. Various efforts made to date for the control of coordinated multiple manipulators is summarized.

  17. GPS/MEMS IMU/Microprocessor Board for Navigation

    NASA Technical Reports Server (NTRS)

    Gender, Thomas K.; Chow, James; Ott, William E.

    2009-01-01

    A miniaturized instrumentation package comprising a (1) Global Positioning System (GPS) receiver, (2) an inertial measurement unit (IMU) consisting largely of surface-micromachined sensors of the microelectromechanical systems (MEMS) type, and (3) a microprocessor, all residing on a single circuit board, is part of the navigation system of a compact robotic spacecraft intended to be released from a larger spacecraft [e.g., the International Space Station (ISS)] for exterior visual inspection of the larger spacecraft. Variants of the package may also be useful in terrestrial collision-detection and -avoidance applications. The navigation solution obtained by integrating the IMU outputs is fed back to a correlator in the GPS receiver to aid in tracking GPS signals. The raw GPS and IMU data are blended in a Kalman filter to obtain an optimal navigation solution, which can be supplemented by range and velocity data obtained by use of (l) a stereoscopic pair of electronic cameras aboard the robotic spacecraft and/or (2) a laser dynamic range imager aboard the ISS. The novelty of the package lies mostly in those aspects of the design of the MEMS IMU that pertain to controlling mechanical resonances and stabilizing scale factors and biases.

  18. MicroShell Minimalist Shell for Xilinx Microprocessors

    NASA Technical Reports Server (NTRS)

    Werne, Thomas A.

    2011-01-01

    MicroShell is a lightweight shell environment for engineers and software developers working with embedded microprocessors in Xilinx FPGAs. (MicroShell has also been successfully ported to run on ARM Cortex-M1 microprocessors in Actel ProASIC3 FPGAs, but without project-integration support.) Micro Shell decreases the time spent performing initial tests of field-programmable gate array (FPGA) designs, simplifies running customizable one-time-only experiments, and provides a familiar-feeling command-line interface. The program comes with a collection of useful functions and enables the designer to add an unlimited number of custom commands, which are callable from the command-line. The commands are parameterizable (using the C-based command-line parameter idiom), so the designer can use one function to exercise hardware with different values. Also, since many hardware peripherals instantiated in FPGAs have reasonably simple register-mapped I/O interfaces, the engineer can edit and view hardware parameter settings at any time without stopping the processor. MicroShell comes with a set of support scripts that interface seamlessly with Xilinx's EDK tool. Adding an instance of MicroShell to a project is as simple as marking a check box in a library configuration dialog box and specifying a software project directory. The support scripts then examine the hardware design, build design-specific functions, conditionally include processor-specific functions, and complete the compilation process. For code-size constrained designs, most of the stock functionality can be excluded from the compiled library. When all of the configurable options are removed from the binary, MicroShell has an unoptimized memory footprint of about 4.8 kB and a size-optimized footprint of about 2.3 kB. Since MicroShell allows unfettered access to all processor-accessible memory locations, it is possible to perform live patching on a running system. This can be useful, for instance, if a bug is

  19. Towards translational therapies for multiple system atrophy

    PubMed Central

    Kuzdas-Wood, Daniela; Stefanova, Nadia; Jellinger, Kurt A.; Seppi, Klaus; Schlossmacher, Michael G.; Poewe, Werner; Wenning, Gregor K.

    2014-01-01

    Multiple system atrophy (MSA) is a fatal adult-onset neurodegenerative disorder of uncertain etiopathogenesis manifesting with autonomic failure, parkinsonism, and ataxia in any combination. The underlying neuropathology affects central autonomic, striatonigral and olivopontocerebellar pathways and it is associated with distinctive glial cytoplasmic inclusions (GCIs, Papp-Lantos bodies) that contain aggregates of α-synuclein. Current treatment options are very limited and mainly focused on symptomatic relief, whereas disease modifying options are lacking. Despite extensive testing, no neuroprotective drug treatment has been identified up to now; however, a neurorestorative approach utilizing autologous mesenchymal stem cells has shown remarkable beneficial effects in the cerebellar variant of MSA. Here, we review the progress made over the last decade in defining pathogenic targets in MSA and summarize insights gained from candidate disease-modifying interventions that have utilized a variety of well-established preclinical MSA models. We also discuss the current limitations that our field faces and suggest solutions for possible approaches in cause-directed therapies of MSA. PMID:24598411

  20. Novel Therapeutic Approaches in Multiple System Atrophy

    PubMed Central

    Palma, Jose-Alberto; Kaufmann, Horacio

    2014-01-01

    Multiple system atrophy (MSA) is a sporadic, adult onset, relentlessly, progressive neurodegenerative disease characterized by autonomic abnormalities associated with parkinsonism, cerebellar dysfunction, pyramidal signs, or combinations thereof. Treatments that can halt or reverse the progression of MSA have not yet been identified. MSA is neuropathologically defined by the presence of α-synuclein–containing inclusions, particularly in the cytoplasm of oligodendrocytes (glial cytoplasmic inclusions, GCIs), which are associated with neurodegeneration. The mechanisms by which oligodendrocytic α-synuclein inclusions cause neuronal death in MSA are not completely understood. The MSA neurodegenerative process likely comprise cell-to-cell transmission of α-synuclein in a prion-like manner, α-synuclein aggregation, increased oxidative stress, abnormal expression of tubulin proteins, decreased expression of neurotrophic factors, excitotoxicity and microglial activation, and neuroinflammation. In an attempt to block each of these pathogenic mechanisms, several pharmacologic approaches have been tried and shown to exert neuroprotective effects in transgenic mouse or cellular models of MSA. These include sertraline, paroxetine, and lithium, which hamper arrival of α-synuclein to oligodendroglia; rifampicin, lithium, and non-steroidal anti-inflamatory drugs, which inhibit α-synuclein aggregation in oligodendrocytes; riluzole, rasagiline, fluoxetine and mesenchimal stem cells, which exert neuroprotective actions; and minocycline and intravenous immunoglobulins, which reduce neuroinflammation and microglial activation. These and other potential therapeutic strategies for MSA are summarized in this review. PMID:24928797

  1. The biological microprocessor, or how to build a computer with biological parts

    PubMed Central

    Moe-Behrens, Gerd HG

    2013-01-01

    Systemics, a revolutionary paradigm shift in scientific thinking, with applications in systems biology, and synthetic biology, have led to the idea of using silicon computers and their engineering principles as a blueprint for the engineering of a similar machine made from biological parts. Here we describe these building blocks and how they can be assembled to a general purpose computer system, a biological microprocessor. Such a system consists of biological parts building an input / output device, an arithmetic logic unit, a control unit, memory, and wires (busses) to interconnect these components. A biocomputer can be used to monitor and control a biological system. PMID:24688733

  2. A lightweight security scheme for wireless body area networks: design, energy evaluation and proposed microprocessor design.

    PubMed

    Selimis, Georgios; Huang, Li; Massé, Fabien; Tsekoura, Ioanna; Ashouei, Maryam; Catthoor, Francky; Huisken, Jos; Stuyt, Jan; Dolmans, Guido; Penders, Julien; De Groot, Harmke

    2011-10-01

    In order for wireless body area networks to meet widespread adoption, a number of security implications must be explored to promote and maintain fundamental medical ethical principles and social expectations. As a result, integration of security functionality to sensor nodes is required. Integrating security functionality to a wireless sensor node increases the size of the stored software program in program memory, the required time that the sensor's microprocessor needs to process the data and the wireless network traffic which is exchanged among sensors. This security overhead has dominant impact on the energy dissipation which is strongly related to the lifetime of the sensor, a critical aspect in wireless sensor network (WSN) technology. Strict definition of the security functionality, complete hardware model (microprocessor and radio), WBAN topology and the structure of the medium access control (MAC) frame are required for an accurate estimation of the energy that security introduces into the WBAN. In this work, we define a lightweight security scheme for WBAN, we estimate the additional energy consumption that the security scheme introduces to WBAN based on commercial available off-the-shelf hardware components (microprocessor and radio), the network topology and the MAC frame. Furthermore, we propose a new microcontroller design in order to reduce the energy consumption of the system. Experimental results and comparisons with other works are given.

  3. Multiple-channel Streaming Delivery for Omnidirectional Vision System

    NASA Astrophysics Data System (ADS)

    Iwai, Yoshio; Nagahara, Hajime; Yachida, Masahiko

    An omnidirectional vision is an imaging system that can capture a surrounding image in whole direction by using a hyperbolic mirror and a conventional CCD camera. This paper proposes a streaming server that can efficiently transfer movies captured by an omnidirectional vision system through the Internet. The proposed system uses multiple channels to deliver multiple movies synchronously. Through this method, the system enables clients to view the different direction of omnidirectional movies and also support the function to change the view are during playback period. Our evaluation experiments show that our proposed streaming server can effectively deliver multiple movies via multiple channels.

  4. The Single Event Effect Characteristics of the 486-DX4 Microprocessor

    NASA Technical Reports Server (NTRS)

    Kouba, Coy; Choi, Gwan

    1996-01-01

    This research describes the development of an experimental radiation testing environment to investigate the single event effect (SEE) susceptibility of the 486-DX4 microprocessor. SEE effects are caused by radiation particles that disrupt the logic state of an operating semiconductor, and include single event upsets (SEU) and single event latchup (SEL). The relevance of this work can be applied directly to digital devices that are used in spaceflight computer systems. The 486-DX4 is a powerful commercial microprocessor that is currently under consideration for use in several spaceflight systems. As part of its selection process, it must be rigorously tested to determine its overall reliability in the space environment, including its radiation susceptibility. The goal of this research is to experimentally test and characterize the single event effects of the 486-DX4 microprocessor using a cyclotron facility as the fault-injection source. The test philosophy is to focus on the "operational susceptibility," by executing real software and monitoring for errors while the device is under irradiation. This research encompasses both experimental and analytical techniques, and yields a characterization of the 486-DX4's behavior for different operating modes. Additionally, the test methodology can accommodate a wide range of digital devices, such as microprocessors, microcontrollers, ASICS, and memory modules, for future testing. The goals were achieved by testing with three heavy-ion species to provide different linear energy transfer rates, and a total of six microprocessor parts were tested from two different vendors. A consistent set of error modes were identified that indicate the manner in which the errors were detected in the processor. The upset cross-section curves were calculated for each error mode, and the SEU threshold and saturation levels were identified for each processor. Results show a distinct difference in the upset rate for different configurations of

  5. 78 FR 12354 - Certain Microprocessors, Components Thereof, and Products Containing Same; Termination of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-22

    ... From the Federal Register Online via the Government Publishing Office INTERNATIONAL TRADE COMMISSION Certain Microprocessors, Components Thereof, and Products Containing Same; Termination of... microprocessors, Apple Inc. of Cupertino, California (``Apple''); and Hewlett-Packard Company of Palo...

  6. Multiple operating system rotation environment moving target defense

    DOEpatents

    Evans, Nathaniel; Thompson, Michael

    2016-03-22

    Systems and methods for providing a multiple operating system rotation environment ("MORE") moving target defense ("MTD") computing system are described. The MORE-MTD system provides enhanced computer system security through a rotation of multiple operating systems. The MORE-MTD system increases attacker uncertainty, increases the cost of attacking the system, reduces the likelihood of an attacker locating a vulnerability, and reduces the exposure time of any located vulnerability. The MORE-MTD environment is effectuated by rotation of the operating systems at a given interval. The rotating operating systems create a consistently changing attack surface for remote attackers.

  7. Application Specific Chemical Information Microprocessor (ASCI mu P)

    DTIC Science & Technology

    2016-06-13

    Application Specific Chemical Information Microprocessor (ASCI µP) David Fries U. South Florida, Marine Science Dept, 140 7TH Ave So. St. Petersburg...00-00-1999 to 00-00-1999 4. TITLE AND SUBTITLE Application Specific Chemical Information Microprocessor (ASCI μP) 5a. CONTRACT NUMBER 5b. GRANT...NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND

  8. Study of limitations and attributes of microprocessor testing techniques

    NASA Technical Reports Server (NTRS)

    Mccaskill, R.; Sohl, W. E.

    1977-01-01

    All microprocessor units have a similar architecture from which a basic test philosophy can be adopted and used to develop an approach to test each module separately in order to verify the functionality of each module within the device using the input/output pins of the device and its instruction set; test for destructive interaction between functional modules; and verify all timing, status information, and interrupt operations of the device. Block and test flow diagrams are given for the 8080, 8008, 2901, 6800, and 1802 microprocessors. Manufacturers are listed and problems encountered in testing the modules are discussed. Test equipment and methods are described.

  9. Use of electronic microprocessor-based instrumentation by the U.S. geological survey for hydrologic data collection

    USGS Publications Warehouse

    Shope, William G.; ,

    1991-01-01

    The U.S. Geological Survey is acquiring a new generation of field computers and communications software to support hydrologic data-collection at field locations. The new computer hardware and software mark the beginning of the Survey's transition from the use of electromechanical devices and paper tapes to electronic microprocessor-based instrumentation. Software is being developed for these microprocessors to facilitate the collection, conversion, and entry of data into the Survey's National Water Information System. The new automated data-collection process features several microprocessor-controlled sensors connected to a serial digital multidrop line operated by an electronic data recorder. Data are acquired from the sensors in response to instructions programmed into the data recorder by the user through small portable lap-top or hand-held computers. The portable computers, called personal field computers, also are used to extract data from the electronic recorders for transport by courier to the office computers. The Survey's alternative to manual or courier retrieval is the use of microprocessor-based remote telemetry stations. Plans have been developed to enhance the Survey's use of the Geostationary Operational Environmental Satellite telemetry by replacing the present network of direct-readout ground stations with less expensive units. Plans also provide for computer software that will support other forms of telemetry such as telephone or land-based radio.

  10. Microprocessors in U.S. Electrical Engineering Departments, 1974-1975.

    ERIC Educational Resources Information Center

    Sloan, M. E.

    Drawn from a survey of engineering departments known to be teaching microprocessor courses, this paper shows that the adoption of microprocessors by Electrical Engineering Departments has been rapid compared with their adoption of minicomputers. The types of courses that are being taught can be categorized as: surveys of microprocessors, intensive…

  11. Multiple channel secure communication using chaotic system encoding

    SciTech Connect

    Miller, S.L.

    1996-12-31

    fA new method to encrypt signals using chaotic systems has been developed that offers benefits over conventional chaotic encryption methods. The method simultaneously encodes multiple plaintext streams using a chaotic system; a key is required to extract the plaintext from the chaotic cipertext. A working prototype demonstrates feasibility of the method by simultaneously encoding and decoding multiple audio signals using electrical circuits.

  12. Redundant Multiple-Valued Number Systems

    DTIC Science & Technology

    1997-07-01

    Fibonacci ou de nombres de Lucas ,” Bull. Soc. Royale Sci. Liege 41, 1972, pp. 179-182. 14-1 ABSTRACT We survey number systems in which the...Figure 5. The 4-Bit One’s Complement Number System. E. FIBONACCI NUMBER SYSTEM The Fibonacci number system is the second example of a redundant number ...instead of powers of 2 or -2, Fibonacci numbers are used as the base. In such a number system, there are many redundant representatives. Fig.

  13. Fault and operating data collection features of a new microprocessor recloser control

    SciTech Connect

    Dolnik, T.G. . Thomas A. Edison Technical Center); Kischefsky, J.A. )

    1990-01-01

    Distribution system operation and maintenance procedures are often conducted with a data base of estimated parameters. This provides satisfactory system performance but not necessarily optimum efficiency or economy. The authors discuss how, to replace the estimated numbers in the data base, actual values can be obtained at points on the feeder that are served with a microprocessor controlled automatic circuit recloser. A control with capabilities to obtain these values can provide normal line current data tabulated over a 24 hour period, accumulated duty on the recloser contacts and can collect data history that keeps track of the various operations of the recloser.

  14. Structural system reliability under multiple failure modes

    NASA Technical Reports Server (NTRS)

    Mahadevan, S.; Chamis, C. C.

    1993-01-01

    This paper describes a computational method for system reliability estimation of propulsion structures. The failure domain of the entire structural system is computed through the union of failure regions for various critical system failure modes. The effect of non-critical progressive damage is incorporated through structural reanalysis, resulting in the construction of several linear segments to approximately cover the system failure domain. An adaptive damage imposition scheme is outlined for the sake of computational efficiency. The proposed method is used to construct the system survival cdf (cumulative distribution function) of a two-rotor system.

  15. Method and system of integrating information from multiple sources

    SciTech Connect

    Alford, Francine A.; Brinkerhoff, David L.

    2006-08-15

    A system and method of integrating information from multiple sources in a document centric application system. A plurality of application systems are connected through an object request broker to a central repository. The information may then be posted on a webpage. An example of an implementation of the method and system is an online procurement system.

  16. Multiple IMU system development, volume 1

    NASA Technical Reports Server (NTRS)

    Landey, M.; Mckern, R.

    1974-01-01

    A redundant gimballed inertial system is described. System requirements and mechanization methods are defined and hardware and software development is described. Failure detection and isolation algorithms are presented and technology achievements described. Application of the system as a test tool for shuttle avionics concepts is outlined.

  17. Guided Multiple Launch Rocket System/Guided Multiple Launch Rocket System Alternative Warhead (GMLRS/GMLRS AW)

    DTIC Science & Technology

    2015-12-01

    Selected Acquisition Report (SAR) RCS: DD-A&T(Q&A)823-260 Guided Multiple Launch Rocket System/Guided Multiple Launch Rocket System Alternative... Selected Acquisition Report SCP - Service Cost Position TBD - To Be Determined TY - Then Year UCR - Unit Cost Reporting U.S. - United States USD(AT

  18. A radiation-hardened 16/32-bit microprocessor

    SciTech Connect

    Hass, K.J.; Treece, R.K.; Giddings, A.E.

    1989-01-01

    A radiation-hardened 16/32-bit microprocessor has been fabricated and tested. Our initial evaluation has demonstrated that it is functional after a total gamma dose of 5Mrad(Si) and is immune to SEU from Krypton ions. 3 refs., 2 figs.

  19. SEU characterization and design dependence of the SA3300 microprocessor

    SciTech Connect

    Sexton, F.W.; Treece, R.K.; Axness, C.L.; Hughes, K.H.; Hash, G.L.; Hass, K.J.

    1990-01-01

    The SA3300 16-bit microprocessor is a key component for interplanetary space probes to be launched in the 1990's. A full SEU characterization of the D-latches of the SA3300 is given, including pattern sensitivity and temperature. 9 refs., 5 figs.

  20. Variable-thermoinsulation garments with a microprocessor temperature controller.

    PubMed

    Kurczewska, Agnieszka; Leánikowski, Jacek

    2008-01-01

    This paper presents the concept of active variable thermoinsulation clothing for users working in low temperatures. Those garments contain heating inserts regulated by a microprocessor temperature controller. This paper also presents the results of tests carried out on the newly designed garments.

  1. Advanced Electricity. Microprocessors and Robotics. Curriculum Development. Bulletin 1803.

    ERIC Educational Resources Information Center

    Southeastern Louisiana Univ., Hammond.

    This model instructional unit was developed to aid industrial arts/technology education teachers in Louisiana to teach a course on microprocessors and robotics in grades 11 and 12. It provides guidance on model performance objectives, current technology content, sources, and supplemental materials. Following a course description, rationale, and…

  2. Bridging the Gap from Gates to Microprocessors in Ten Hours.

    ERIC Educational Resources Information Center

    Larson, Allen L.

    The advent of microprocessor technology requires that the teaching of computer basics become a part of undergraduate digital electronics courses. This paper describes a laboratory-oriented approach to basic instruction requiring less than 10 hours student study time. The technique utilizes a programmed text and a small 4-bit computer,…

  3. Microprocessor-based fault-tolerant nuclear turbine governor

    SciTech Connect

    Tone, Y.; Nakamura, H.; Yokota, Y.

    1986-02-01

    A new microprocessor-based fault-tolerant nuclear turbine governor has been developed. Hierarchically distributed configuration and asynchronous triplicated architecture with middle value voting logic maximizes the plant availability. Problem-oriented language is provided for design ease and program maintainability. The turbine governor with these features is described with test results.

  4. Dynamical configurations of celestial systems comprised of multiple irregular bodies

    NASA Astrophysics Data System (ADS)

    Jiang, Yu; Zhang, Yun; Baoyin, Hexi; Li, Junfeng

    2016-09-01

    This manuscript considers the main features of the nonlinear dynamics of multiple irregular celestial body systems. The gravitational potential, static electric potential, and magnetic potential are considered. Based on the three established potentials, we show that three conservative values exist for this system, including a Jacobi integral. The equilibrium conditions for the system are derived and their stability analyzed. The equilibrium conditions of a celestial system comprised of n irregular bodies are reduced to 12n - 9 equations. The dynamical results are applied to simulate the motion of multiple-asteroid systems. The simulation is useful for the study of the stability of multiple irregular celestial body systems and for the design of spacecraft orbits to triple-asteroid systems discovered in the solar system. The dynamical configurations of the five triple-asteroid systems 45 Eugenia, 87 Sylvia, 93 Minerva, 216 Kleopatra, and 136617 1994CC, and the six-body system 134340 Pluto are calculated and analyzed.

  5. Multiple system modelling of waste management.

    PubMed

    Eriksson, Ola; Bisaillon, Mattias

    2011-12-01

    Due to increased environmental awareness, planning and performance of waste management has become more and more complex. Therefore waste management has early been subject to different types of modelling. Another field with long experience of modelling and systems perspective is energy systems. The two modelling traditions have developed side by side, but so far there are very few attempts to combine them. Waste management systems can be linked together with energy systems through incineration plants. The models for waste management can be modelled on a quite detailed level whereas surrounding systems are modelled in a more simplistic way. This is a problem, as previous studies have shown that assumptions on the surrounding system often tend to be important for the conclusions. In this paper it is shown how two models, one for the district heating system (MARTES) and another one for the waste management system (ORWARE), can be linked together. The strengths and weaknesses with model linking are discussed when compared to simplistic assumptions on effects in the energy and waste management systems. It is concluded that the linking of models will provide a more complete, correct and credible picture of the consequences of different simultaneous changes in the systems. The linking procedure is easy to perform and also leads to activation of project partners. However, the simulation procedure is a bit more complicated and calls for the ability to run both models.

  6. Modernization of the multiple launch rocket system embedded system software

    NASA Astrophysics Data System (ADS)

    Mockensturm, Jeffrey J.

    1995-03-01

    Weapon systems in the Department of Defense (DOD) are becoming increasingly reliant on embedded software. As the size and level of complexity of these software development efforts have increased, the management of these programs has become more challenging. Additionally, as the Army strives to digitize the future battlefield, the demand for software will only increase. This thesis reviews the software development efforts associated with modernizing the Army's Multiple Launch Rocket System (MLRS). The thesis begins by presenting a background discussion of the Army's Fire Direction Data Manager (FDDM) development. After the FDDM background discussion, a case study of the troubled FDDM software development effort is presented. The FDDM case study follows the general format presented in the May 1992 General Accounting Office report on the FDDM software development difficulties. Following the FDDM review, the current MLRS software development effort, the Improved Fire Control System (IFCS), is presented. Next, the FDDM case study is reviewed to determine the software development lessons learned. Using the FDDM software lessons learned, the IFCS program is analyzed to determine the software risks, and to review the risk mitigation strategies of that program. The objective of the thesis is to provide insight into the use of modern software management methods in reducing software development program risk.

  7. Switched Systems With Multiple Invariant Sets

    DTIC Science & Technology

    2015-05-06

    and flapping flight. Keywords: Switched systems, Non- equilibrium steady state, Set-based control 1. Introduction Bifurcations have been of interest to...Motor Control Mode Figure 1: Schematic of mode switching with non- equilibrium limit sets. with σ = 1. For a positive rate of convergence λ > 0, it...body of literature on switched 2 systems [3]. Most work on stability of switched systems assumes that all subsystems have a common equilibrium point. [4

  8. Multiple system modelling of waste management

    SciTech Connect

    Eriksson, Ola; Bisaillon, Mattias

    2011-12-15

    Highlights: > Linking of models will provide a more complete, correct and credible picture of the systems. > The linking procedure is easy to perform and also leads to activation of project partners. > The simulation procedure is a bit more complicated and calls for the ability to run both models. - Abstract: Due to increased environmental awareness, planning and performance of waste management has become more and more complex. Therefore waste management has early been subject to different types of modelling. Another field with long experience of modelling and systems perspective is energy systems. The two modelling traditions have developed side by side, but so far there are very few attempts to combine them. Waste management systems can be linked together with energy systems through incineration plants. The models for waste management can be modelled on a quite detailed level whereas surrounding systems are modelled in a more simplistic way. This is a problem, as previous studies have shown that assumptions on the surrounding system often tend to be important for the conclusions. In this paper it is shown how two models, one for the district heating system (MARTES) and another one for the waste management system (ORWARE), can be linked together. The strengths and weaknesses with model linking are discussed when compared to simplistic assumptions on effects in the energy and waste management systems. It is concluded that the linking of models will provide a more complete, correct and credible picture of the consequences of different simultaneous changes in the systems. The linking procedure is easy to perform and also leads to activation of project partners. However, the simulation procedure is a bit more complicated and calls for the ability to run both models.

  9. Analysis of bilinear stochastic systems. [involving multiplicative noise processes

    NASA Technical Reports Server (NTRS)

    Willsky, A. S.; Marcus, S. I.; Martin, D. N.

    1974-01-01

    Analysis of stochastic dynamical systems that involve multiplicative (bilinear) noise processes is considered. After defining the systems of interest, the evolution of the moments of such systems, the question of stochastic stability, and estimation for bilinear stochastic systems are discussed. Both exact and approximate methods of analysis are introduced, and, in particular, the uses of Lie-theoretic concepts and harmonic analysis are discussed.

  10. Seismic isolation systems with distinct multiple frequencies

    DOEpatents

    Wu, Ting-shu; Seidensticker, Ralph W.

    1990-01-01

    A method and apparatus for isolating a building or other structure from smic vibratory motion which provides increased assurance that large horizontal motion of the structure will not occur than is provided by other isolation systems. Increased assurance that large horizontal motion will not occur is achieved by providing for change of the natural frequency of the support and structure system in response to displacement of the structure beyond a predetermined value. The natural frequency of the support and structure system may be achieved by providing for engaging and disengaging of the structure and some supporting members in response to motion of the supported structure.

  11. Supporting multiple control systems at Fermilab

    SciTech Connect

    Nicklaus, Dennis J.; /Fermilab

    2009-10-01

    The Fermilab control system, ACNET, is used for controlling the Tevatron and all of its pre-accelerators. However, other smaller experiments at Fermilab have been using different controls systems, in particular DOOCS and EPICS. This paper reports some of the steps taken at Fermilab to integrate support for these outside systems. We will describe specific tools that we have built or adapted to facilitate interaction between the architectures. We also examine some of the difficulties that arise from managing this heterogeneous environment. Incompatibilities as well as common elements will be described.

  12. Adaptable Transponder for Multiple Telemetry Systems

    NASA Technical Reports Server (NTRS)

    Sims, William Herbert, III (Inventor); Varnavas, Kosta A. (Inventor)

    2014-01-01

    The present invention is a stackable telemetry circuit board for use in telemetry systems for satellites and other purposes. The present invention incorporates previously-qualified interchangeable circuit boards, or "decks," that perform functions such as power, signal receiving and transmission, and processing. Each deck is adapted to serve a range of telemetry applications. This provides flexibility in the construction of the stackable telemetry circuit board and significantly reduces the cost and time necessary to develop a telemetry system.

  13. A Decision Support System for Solving Multiple Criteria Optimization Problems

    ERIC Educational Resources Information Center

    Filatovas, Ernestas; Kurasova, Olga

    2011-01-01

    In this paper, multiple criteria optimization has been investigated. A new decision support system (DSS) has been developed for interactive solving of multiple criteria optimization problems (MOPs). The weighted-sum (WS) approach is implemented to solve the MOPs. The MOPs are solved by selecting different weight coefficient values for the criteria…

  14. A rocket-borne data-manipulation experiment using a microprocessor

    NASA Technical Reports Server (NTRS)

    Davis, L. L.; Smith, L. G.; Voss, H. D.

    1979-01-01

    The development of a data-manipulation experiment using a Z-80 microprocessor is described. The instrumentation is included in the payloads of two Nike Apache sounding rockets used in an investigation of energetic particle fluxes. The data from an array of solid-state detectors and an electrostatic analyzer is processed to give the energy spectrum as a function of pitch angle. The experiment performed well in its first flight test: Nike Apache 14.543 was launched from Wallops Island at 2315 EST on 19 June 1978. The system was designed to be easily adaptable to other data-manipulation requirements and some suggestions for further development are included.

  15. Multiple Drosophila Tracking System with Heading Direction

    PubMed Central

    Sirigrivatanawong, Pudith; Arai, Shogo; Thoma, Vladimiros; Hashimoto, Koichi

    2017-01-01

    Machine vision systems have been widely used for image analysis, especially that which is beyond human ability. In biology, studies of behavior help scientists to understand the relationship between sensory stimuli and animal responses. This typically requires the analysis and quantification of animal locomotion. In our work, we focus on the analysis of the locomotion of the fruit fly Drosophila melanogaster, a widely used model organism in biological research. Our system consists of two components: fly detection and tracking. Our system provides the ability to extract a group of flies as the objects of concern and furthermore determines the heading direction of each fly. As each fly moves, the system states are refined with a Kalman filter to obtain the optimal estimation. For the tracking step, combining information such as position and heading direction with assignment algorithms gives a successful tracking result. The use of heading direction increases the system efficiency when dealing with identity loss and flies swapping situations. The system can also operate with a variety of videos with different light intensities. PMID:28067800

  16. Microprocessor-based integration of microfluidic control for the implementation of automated sensor monitoring and multithreaded optimization algorithms.

    PubMed

    Ezra, Elishai; Maor, Idan; Bavli, Danny; Shalom, Itai; Levy, Gahl; Prill, Sebastian; Jaeger, Magnus S; Nahmias, Yaakov

    2015-08-01

    Microfluidic applications range from combinatorial synthesis to high throughput screening, with platforms integrating analog perfusion components, digitally controlled micro-valves and a range of sensors that demand a variety of communication protocols. Currently, discrete control units are used to regulate and monitor each component, resulting in scattered control interfaces that limit data integration and synchronization. Here, we present a microprocessor-based control unit, utilizing the MS Gadgeteer open framework that integrates all aspects of microfluidics through a high-current electronic circuit that supports and synchronizes digital and analog signals for perfusion components, pressure elements, and arbitrary sensor communication protocols using a plug-and-play interface. The control unit supports an integrated touch screen and TCP/IP interface that provides local and remote control of flow and data acquisition. To establish the ability of our control unit to integrate and synchronize complex microfluidic circuits we developed an equi-pressure combinatorial mixer. We demonstrate the generation of complex perfusion sequences, allowing the automated sampling, washing, and calibrating of an electrochemical lactate sensor continuously monitoring hepatocyte viability following exposure to the pesticide rotenone. Importantly, integration of an optical sensor allowed us to implement automated optimization protocols that require different computational challenges including: prioritized data structures in a genetic algorithm, distributed computational efforts in multiple-hill climbing searches and real-time realization of probabilistic models in simulated annealing. Our system offers a comprehensive solution for establishing optimization protocols and perfusion sequences in complex microfluidic circuits.

  17. Absolute stability for multiple delay general Lur'e control systems with multiple nonlinearities

    NASA Astrophysics Data System (ADS)

    He, Yong; Wu, Min

    2003-10-01

    In this paper, necessary and sufficient conditions are obtained for the existence of Lyapunov functional of extended Lur'e form to guarantee absolute stability for multiple delay general Lur'e control systems with multiple nonlinearities, and the existence reduces to a problem of solving a group of linear matrix inequalities (LMIs). When the LMIs are feasible, the free parameters in the Lyapunov functional are given by the solution of these LMIs. Otherwise, this class of Lyapunov functional does not exist.

  18. Software simulator for multiple computer simulation system

    NASA Technical Reports Server (NTRS)

    Ogrady, E. P.

    1983-01-01

    A description is given of the structure and use of a computer program that simulates the operation of a parallel processor simulation system. The program is part of an investigation to determine algorithms that are suitable for simulating continous systems on a parallel processor configuration. The simulator is designed to accurately simulate the problem-solving phase of a simulation study. Care has been taken to ensure the integrity and correctness of data exchanges and to correctly sequence periods of computation and periods of data exchange. It is pointed out that the functions performed during a problem-setup phase or a reset phase are not simulated. In particular, there is no attempt to simulate the downloading process that loads object code into the local, transfer, and mapping memories of processing elements or the memories of the run control processor and the system control processor. The main program of the simulator carries out some problem-setup functions of the system control processor in that it requests the user to enter values for simulation system parameters and problem parameters. The method by which these values are transferred to the other processors, however, is not simulated.

  19. A rocket-borne microprocessor-based experiment for investigation of energetic particles in the D and E regions

    NASA Technical Reports Server (NTRS)

    Braswell, F. M.

    1981-01-01

    An energetic experiment using the Z80 family of microcomputer components is described. Data collected from the experiment allowed fast and efficient postprocessing, yielding both energy-spectrum and pitch-angle distribution of energetic particles in the D and E regions. Advanced microprocessor system architecture and software concepts were used in the design to cope with the large amount of data being processed. This required the Z80 system to operate at over 80% of its total capacity. The microprocessor system was included in the payloads of three rockets launched during the Energy Budget Campaign at ESRANGE, Kiruna, Sweden in November 1980. Based on preliminary examination of the data, the performance of the experiment was satisfactory and good data were obtained on the energy spectrum and pitch-angle distribution of the particles.

  20. Multiple strategies of reasoning for expert systems

    SciTech Connect

    Yao Yuchuan; Kulikowski, C.A.

    1983-01-01

    In expert systems the heuristics used for combining the weight of evidence can be based on probabilistic, fuzzy set, or subjective confidence factors. Although the underlying assumptions for each of the methods differ, it can be shown that there are correspondences between them and that it is possible to develop a model of expert reasoning for medical consultation using any one of the methods. The authors have developed a system for representing expert knowledge, called ESMES, which is an outgrowth of the expert scheme developed earlier at Rutgers. ESMES allows the use of alternative strategies in the solution of a consultation problem. The authors report on the performance of ESMES for a prototype glaucoma consultation model, using reasoning mechanisms similar to those of the expert, MYCIN, Internist I, and Prospector systems. 9 references.

  1. Exoplanet orbital eccentricity: multiplicity relation and the Solar System.

    PubMed

    Limbach, Mary Anne; Turner, Edwin L

    2015-01-06

    The known population of exoplanets exhibits a much wider range of orbital eccentricities than Solar System planets and has a much higher average eccentricity. These facts have been widely interpreted to indicate that the Solar System is an atypical member of the overall population of planetary systems. We report here on a strong anticorrelation of orbital eccentricity with multiplicity (number of planets in the system) among cataloged radial velocity (RV) systems. The mean, median, and rough distribution of eccentricities of Solar System planets fits an extrapolation of this anticorrelation to the eight-planet case rather precisely despite the fact that no more than two Solar System planets would be detectable with RV data comparable to that in the exoplanet sample. Moreover, even if regarded as a single or double planetary system, the Solar System lies in a reasonably heavily populated region of eccentricity-multiplicity space. Thus, the Solar System is not anomalous among known exoplanetary systems with respect to eccentricities when its multiplicity is taken into account. Specifically, as the multiplicity of a system increases, the eccentricity decreases roughly as a power law of index -1.20. A simple and plausible but ad hoc and model-dependent interpretation of this relationship implies that ∼ 80% of the one-planet and 25% of the two-planet systems in our sample have additional, as yet undiscovered, members but that systems of higher observed multiplicity are largely complete (i.e., relatively rarely contain additional undiscovered planets). If low eccentricities indeed favor high multiplicities, habitability may be more common in systems with a larger number of planets.

  2. Exoplanet orbital eccentricity: Multiplicity relation and the Solar System

    PubMed Central

    Limbach, Mary Anne; Turner, Edwin L.

    2015-01-01

    The known population of exoplanets exhibits a much wider range of orbital eccentricities than Solar System planets and has a much higher average eccentricity. These facts have been widely interpreted to indicate that the Solar System is an atypical member of the overall population of planetary systems. We report here on a strong anticorrelation of orbital eccentricity with multiplicity (number of planets in the system) among cataloged radial velocity (RV) systems. The mean, median, and rough distribution of eccentricities of Solar System planets fits an extrapolation of this anticorrelation to the eight-planet case rather precisely despite the fact that no more than two Solar System planets would be detectable with RV data comparable to that in the exoplanet sample. Moreover, even if regarded as a single or double planetary system, the Solar System lies in a reasonably heavily populated region of eccentricity−multiplicity space. Thus, the Solar System is not anomalous among known exoplanetary systems with respect to eccentricities when its multiplicity is taken into account. Specifically, as the multiplicity of a system increases, the eccentricity decreases roughly as a power law of index –1.20. A simple and plausible but ad hoc and model-dependent interpretation of this relationship implies that ∼80% of the one-planet and 25% of the two-planet systems in our sample have additional, as yet undiscovered, members but that systems of higher observed multiplicity are largely complete (i.e., relatively rarely contain additional undiscovered planets). If low eccentricities indeed favor high multiplicities, habitability may be more common in systems with a larger number of planets. PMID:25512527

  3. Optoelectronic System Measures Distances to Multiple Targets

    NASA Technical Reports Server (NTRS)

    Liebe, Carl Christian; Abramovici, Alexander; Bartman, Randall; Chapsky, Jacob; Schmalz, John; Coste, Keith; Litty, Edward; Lam, Raymond; Jerebets, Sergei

    2007-01-01

    An optoelectronic metrology apparatus now at the laboratory-prototype stage of development is intended to repeatedly determine distances of as much as several hundred meters, at submillimeter accuracy, to multiple targets in rapid succession. The underlying concept of optoelectronic apparatuses that can measure distances to targets is not new; such apparatuses are commonly used in general surveying and machining. However, until now such apparatuses have been, variously, constrained to (1) a single target or (2) multiple targets with a low update rate and a requirement for some a priori knowledge of target geometry. When fully developed, the present apparatus would enable measurement of distances to more than 50 targets at an update rate greater than 10 Hz, without a requirement for a priori knowledge of target geometry. The apparatus (see figure) includes a laser ranging unit (LRU) that includes an electronic camera (photo receiver), the field of view of which contains all relevant targets. Each target, mounted at a fiducial position on an object of interest, consists of a small lens at the output end of an optical fiber that extends from the object of interest back to the LRU. For each target and its optical fiber, there is a dedicated laser that is used to illuminate the target via the optical fiber. The targets are illuminated, one at a time, with laser light that is modulated at a frequency of 10.01 MHz. The modulated laser light is emitted by the target, from where it returns to the camera (photodetector), where it is detected. Both the outgoing and incoming 10.01-MHz laser signals are mixed with a 10-MHz local-oscillator to obtain beat notes at 10 kHz, and the difference between the phases of the beat notes is measured by a phase meter. This phase difference serves as a measure of the total length of the path traveled by light going out through the optical fiber and returning to the camera (photodetector) through free space. Because the portion of the path

  4. Study and development of smart sensor using microprocessor and microcontroller

    NASA Astrophysics Data System (ADS)

    Sarma, Utpal

    The trend towards replacing dumb sensors with smart ones has been gathering momentum from last two decades. Smart sensors have a number of advantages compared to their dumb counterparts. Ease of installation and operation, field upgradeability, standalone feature, digital communication interface are few of them. Institute of Electrical and Electronics Engineers, Inc. (IEEE) and National Institute of Standards and Technology (NIST) in 1993 initiated the standardisation for smart sensor. This process generates IEEE Std. 1451.1TM -1999, IEEE Std. 1451.2TM -1997, IEEE Std. 1451.3TM - 2003, IEEE Std. 1451.4TM -2004, IEEE Std. 1451.10TM -2007, IEEE Std. 1451.5TM -2007. At present IEEE P1451.6 and IEEE P1451.7 are the proposed standards of smart sensor. The basic motive behind these standards is to build a common platform for sensor network, transducer interface module, transducer electronic data sheets etc. In the present work the design, fabrication, calibration, and performance of such smart sensor system with their functionalities are discussed. Results based on field trial of this system in a tea factory are also discussed. Initially a smart industrial temperature monitoring and data logging system using INTEL 8086 microprocessor is designed, the detail of which is explained in Chapter 2. Here, a K-type thermocouple is considered as the sensor. It incorporates automatic reference junction compensation, signal conditioning, 12-bit A/D conversion and data transmission via RS232C interface. At the user end, PC software handles data monitoring and recording. Calibration of the system using a mercury thermometer and an oil bath is described. The stability of the reference junction compensation is also tested. Certain improvements are found to be necessary in this system, so the system is modified adding some more features. As the TC response is not linear it is linearised using least square polynomial fitting method. The improvements in error are discussed in Chapter 3

  5. ARCHITECTURE AND DYNAMICS OF KEPLER'S CANDIDATE MULTIPLE TRANSITING PLANET SYSTEMS

    SciTech Connect

    Lissauer, Jack J.; Jenkins, Jon M.; Borucki, William J.; Bryson, Stephen T.; Howell, Steve B.; Ragozzine, Darin; Holman, Matthew J.; Carter, Joshua A.; Fabrycky, Daniel C.; Fortney, Jonathan J.; Steffen, Jason H.; Ford, Eric B.; Shporer, Avi; Rowe, Jason F.; Quintana, Elisa V.; Caldwell, Douglas A.; Ciardi, David; Gautier, Thomas N. III; and others

    2011-11-01

    About one-third of the {approx}1200 transiting planet candidates detected in the first four months of Kepler data are members of multiple candidate systems. There are 115 target stars with two candidate transiting planets, 45 with three, 8 with four, and 1 each with five and six. We characterize the dynamical properties of these candidate multi-planet systems. The distribution of observed period ratios shows that the vast majority of candidate pairs are neither in nor near low-order mean-motion resonances. Nonetheless, there are small but statistically significant excesses of candidate pairs both in resonance and spaced slightly too far apart to be in resonance, particularly near the 2:1 resonance. We find that virtually all candidate systems are stable, as tested by numerical integrations that assume a nominal mass-radius relationship. Several considerations strongly suggest that the vast majority of these multi-candidate systems are true planetary systems. Using the observed multiplicity frequencies, we find that a single population of planetary systems that matches the higher multiplicities underpredicts the number of singly transiting systems. We provide constraints on the true multiplicity and mutual inclination distribution of the multi-candidate systems, revealing a population of systems with multiple super-Earth-size and Neptune-size planets with low to moderate mutual inclinations.

  6. Advanced multiple access concepts in mobile satellite systems

    NASA Technical Reports Server (NTRS)

    Ananasso, Fulvio

    1990-01-01

    Some multiple access strategies for Mobile Satellite Systems (MSS) are discussed. These strategies were investigated in the context of three separate studies conducted for the International Maritime Satellite Organization (INMARSAT) and the European Space Agency (ESA). Satellite-Switched Frequency Division Multiple Access (SS-FDMA), Code Division Multiple Access (CDMA), and Frequency-Addressable Beam architectures are addressed, discussing both system and technology aspects and outlining advantages and drawbacks of either solution with associated relevant hardware issues. An attempt is made to compare the considered option from the standpoint of user terminal/space segment complexity, synchronization requirements, spectral efficiency, and interference rejection.

  7. MULTIPLE PROJECTIONS SYSTEM (MPS): USER'S MANUAL VERSION 2.0

    EPA Science Inventory

    The document is a user's manual for Multiple Projections System (MPS) Version 2.0, based on the 3% reasonable further progress (RFP) tracking system that was developed in FY92/FY93. The 3% RFP tracking system is a Windows application, and enhancements to convert the 3% RFP track...

  8. The NP Draconii Multiple Star System

    NASA Astrophysics Data System (ADS)

    Castelaz, Michael W.; Barker, Thurburn; McNaughton, Abby; Robertson, Rachel; Smith, Matt

    2016-01-01

    Otero and Dubovsky used the ASAS-3 (Pojmanski 2002), Hipparcos (Perryman et al 1997) and Northern Sky Variability Survey (NSVS; Wozniak et al 2004) databases to determine elements for 80 eclipsing binaries. NP Draconii (NSV 22984) was identified by Otero and Dubovsky (IBVS Number 5557, 2004) as a possible Algol type variable with an ephemeris of HJD Min I = 2448604.780+3.10886E days based on 84 observations over 326 days with about 2 to 4 observations on any one night. We decided to further refine the ephemeris and observe NP Dra in VRI filters, with the goal of determining the elements of the system.NP Dra is a V = 9.0 system located at J2000 = 17h 35m 16s and +55d 00' 12". We observed NP Dra August 2, 3 and September 15, 16, 17, 18, and 19 2015 UT using the Pisgah Astronomical Research Institute 0.4-m telescope in V, R, and I with 20 second exposure times in each filter. Observations in each filter were repeated about every 3 minutes each night of observing.From our light curves we determined the period using the Date Compensated Discrete Fourier Transform function (Ferraz-Mello 1981) which is part of the open source code VSTAR (AAVSO). The period derived from the observations is 2.2755 days. Superimposed on this period is another period of 0.6398 days. We will present the V, R, and I light curves, period determination and implication

  9. Switched steerable multiple beam antenna system

    NASA Technical Reports Server (NTRS)

    Iwasaki, Richard S. (Inventor)

    1988-01-01

    A steerable multibeam five element cross-feed cluster antenna system is described. The feed power is divided into five branches. Each branch includes a switching network comprised of a plurality of time delay elements each individually controlled by a respective electromagnetic latching switch. Frequency independent individual two-dimensional beam steering at intermediate (IF) scanning frequencies is thereby provided wherein discrete incremental time delays are introduced by the switching networks into each branch and the signals recombined thereafter to form each beam. The electromagnetic latched switching reduces power consumption and permits higher power switching and reciprocal coincident tranmsit and receive operation. Frequency independence due to incremental time delay switching permits coincident reciprocal operation and steering for transmit-receive signal paths carrying different transmit-receive frequencies. Diagonal quarter wave plates in the waveguides alter polarization from the circular to orthogonal linear to provide transmitter-receiver isolation.

  10. Stability and Evolution of Multiple Planet and Satellite Systems

    NASA Astrophysics Data System (ADS)

    Quillen, Alice

    Numerous multiple planet systems have recently been discovered with the Kepler Mission, suggesting that multiple planet systems are common. Multiple- body nearly coplanar satellite systems are also found in the Solar system. Multiple planet and satellite systems exhibit rich dynamics as they are affected by three-body and secular resonances affecting short timescale behavior and long timescale stability. Interactions with debris disks and planetesimal belts and tidal interactions can both reduce and induce instability. Using both numerical and analytical studies, we propose to develop a broadly applicable framework to estimate diffusion rates and stability regimes both in resonant and non- resonant configurations. Understanding of resonant dynamics is needed to understand each of these systems and a broader general theory would cover scenarios and mechanisms that are relevant for all of them. Architectures and dynamical mechanisms will be used to test scenarios for formation and evolution of multiple body systems and constrain poorly known quantities such as masses, eccentricities, inclinations, radii, and the existence of undetected bodies.

  11. 46 CFR 62.25-25 - Programable systems and devices.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... range of the equipment. (b) Operating programs for microprocessor-based or computer-based vital control... power resumption. (c) If a microprocessor-based or computer-based system serves both vital and...

  12. OBSERVATIONS OF HIERARCHICAL SOLAR-TYPE MULTIPLE STAR SYSTEMS

    SciTech Connect

    Roberts, Lewis C. Jr.; Tokovinin, Andrei; Mason, Brian D.; Hartkopf, William I.; Riddle, Reed L.

    2015-10-15

    Twenty multiple stellar systems with solar-type primaries were observed at high angular resolution using the PALM-3000 adaptive optics system at the 5 m Hale telescope. The goal was to complement the knowledge of hierarchical multiplicity in the solar neighborhood by confirming recent discoveries by the visible Robo-AO system with new near-infrared observations with PALM-3000. The physical status of most, but not all, of the new pairs is confirmed by photometry in the Ks band and new positional measurements. In addition, we resolved for the first time five close sub-systems: the known astrometric binary in HIP 17129AB, companions to the primaries of HIP 33555, and HIP 118213, and the companions to the secondaries in HIP 25300 and HIP 101430. We place the components on a color–magnitude diagram and discuss each multiple system individually.

  13. Observations of Hierarchical Solar-type Multiple Star Systems

    NASA Astrophysics Data System (ADS)

    Roberts, Lewis C., Jr.; Tokovinin, Andrei; Mason, Brian D.; Hartkopf, William I.; Riddle, Reed L.

    2015-10-01

    Twenty multiple stellar systems with solar-type primaries were observed at high angular resolution using the PALM-3000 adaptive optics system at the 5 m Hale telescope. The goal was to complement the knowledge of hierarchical multiplicity in the solar neighborhood by confirming recent discoveries by the visible Robo-AO system with new near-infrared observations with PALM-3000. The physical status of most, but not all, of the new pairs is confirmed by photometry in the Ks band and new positional measurements. In addition, we resolved for the first time five close sub-systems: the known astrometric binary in HIP 17129AB, companions to the primaries of HIP 33555, and HIP 118213, and the companions to the secondaries in HIP 25300 and HIP 101430. We place the components on a color-magnitude diagram and discuss each multiple system individually.

  14. Architecture of Kepler's Multiple Planet Systems

    NASA Astrophysics Data System (ADS)

    Lissauer, Jack

    We propose to determine the typical characteristics of planetary systems within 1 AU of stars. We will address basic questions including: How many planets are typical? What are their orbital spacings? How do these relate to planet sizes, relative inclinations, and stellar type? These questions probe the signatures of planet formation that are recorded in the catalogs of Kepler planet candidates. We propose to update the findings Lissauer et al. (2011, ApJS 197, 8), which used the first four months of Kepler observations, and Fabrycky et al. (2014, ApJ 790, 146) to encompass the additional planet candidates that have and will be cataloged by the Kepler project. The current catalog (Coughlin et al. (2015, arXiv 1512.06149) includes four times as many planet candidates as were known in 2011, almost twice as many as the catalog used by Fabrycky et al., as well as vastly improved measures of planetary radii and stellar properties. The improved catalogs will allow us to minimize detection biases andperform independent analyses of subsets of the data to compare distributions of planet periodratios, transit durations and planet radii to determine how these vary with orbital distance orincident fluxes. Analyses of the early Kepler data also identified an excess of planets just wide of resonance and a deficit just narrow of resonance. We propose to discriminate between tidal and dynamical models for this phenomenon with improved distributions of period ratios, sorted by planet size and orbit period, since tidal effects decline rapidly with distance from the star.

  15. Benchmarking Microprocessors for High-End Signal Processing

    DTIC Science & Technology

    2005-02-01

    skycomputers.com There are a number of general- purpose microprocessor architectures which, while not designed for high-end signal processing, might...bandwidth of the processors considered, a trivial vector-sum computation was developed . In this simple benchmark, as well as in others, all of the...efficiency of the 970’s L2 cache and automatic pre-fetch engines . The bandwidth falloff between L1 and L2 caches of this processor is quite minor, whereas

  16. Achieving High Performance on the i860 Microprocessor

    NASA Technical Reports Server (NTRS)

    Lee, King; Kutler, Paul (Technical Monitor)

    1998-01-01

    The i860 is a high performance microprocessor used in the Intel Touchstone project. This paper proposes a paradigm for programming the i860 that is modelled on the vector instructions of the Cray computers. Fortran callable assembler subroutines were written that mimic the concurrent vector instructions of the Cray. Cache takes the place of vector registers. Using this paradigm we have achieved twice the performance of compiled code on a traditional solve.

  17. A microprocessor-based multichannel subsensory stochastic resonance electrical stimulator.

    PubMed

    Chang, Gwo-Ching

    2013-01-01

    Stochastic resonance electrical stimulation is a novel intervention which provides potential benefits for improving postural control ability in the elderly, those with diabetic neuropathy, and stroke patients. In this paper, a microprocessor-based subsensory white noise electrical stimulator for the applications of stochastic resonance stimulation is developed. The proposed stimulator provides four independent programmable stimulation channels with constant-current output, possesses linear voltage-to-current relationship, and has two types of stimulation modes, pulse amplitude and width modulation.

  18. Microprocessor activity controls differential miRNA biogenesis In Vivo.

    PubMed

    Conrad, Thomas; Marsico, Annalisa; Gehre, Maja; Orom, Ulf Andersson

    2014-10-23

    In miRNA biogenesis, pri-miRNA transcripts are converted into pre-miRNA hairpins. The in vivo properties of this process remain enigmatic. Here, we determine in vivo transcriptome-wide pri-miRNA processing using next-generation sequencing of chromatin-associated pri-miRNAs. We identify a distinctive Microprocessor signature in the transcriptome profile from which efficiency of the endogenous processing event can be accurately quantified. This analysis reveals differential susceptibility to Microprocessor cleavage as a key regulatory step in miRNA biogenesis. Processing is highly variable among pri-miRNAs and a better predictor of miRNA abundance than primary transcription itself. Processing is also largely stable across three cell lines, suggesting a major contribution of sequence determinants. On the basis of differential processing efficiencies, we define functionality for short sequence features adjacent to the pre-miRNA hairpin. In conclusion, we identify Microprocessor as the main hub for diversified miRNA output and suggest a role for uncoupling miRNA biogenesis from host gene expression.

  19. G-cueing microcontroller (a microprocessor application in simulators)

    NASA Technical Reports Server (NTRS)

    Horattas, C. G.

    1980-01-01

    A g cueing microcontroller is described which consists of a tandem pair of microprocessors, dedicated to the task of simulating pilot sensed cues caused by gravity effects. This task includes execution of a g cueing model which drives actuators that alter the configuration of the pilot's seat. The g cueing microcontroller receives acceleration commands from the aerodynamics model in the main computer and creates the stimuli that produce physical acceleration effects of the aircraft seat on the pilots anatomy. One of the two microprocessors is a fixed instruction processor that performs all control and interface functions. The other, a specially designed bipolar bit slice microprocessor, is a microprogrammable processor dedicated to all arithmetic operations. The two processors communicate with each other by a shared memory. The g cueing microcontroller contains its own dedicated I/O conversion modules for interface with the seat actuators and controls, and a DMA controller for interfacing with the simulation computer. Any application which can be microcoded within the available memory, the available real time and the available I/O channels, could be implemented in the same controller.

  20. Using Multiple Unmanned Systems for a Site Security Task

    SciTech Connect

    Matthew O. Anderson; Curtis W. Nielsen; Mark D. McKay; Derek C. Wadsworth; Ryan C. Hruska; John A. Koudelka

    2009-04-01

    Unmanned systems are often used to augment the ability of humans to perform challenging tasks. While the value of individual unmanned vehicles have been proven for a variety of tasks, it is less understood how multiple unmanned systems should be used together to accomplish larger missions such as site security. The purpose of this paper is to discuss efforts by researchers at the Idaho National Laboratory (INL) to explore the utility and practicality of operating multiple unmanned systems for a site security mission. This paper reviews the technology developed for a multi-agent mission and summarizes the lessons-learned from a technology demonstration.

  1. MOOSES: Multiple Option Observation System for Experimental Studies.

    ERIC Educational Resources Information Center

    Tapp, Jon; Wehby, Joseph

    The Multiple Option Observation System for Experimental Studies (MOOSES) is a flexible data collection and analysis package for applied behavioral research that addresses the needs of researchers interested in live coding of observational data. MOOSES allows the researcher to design a coding system for a particular research question. General types…

  2. 21 CFR 866.5660 - Multiple autoantibodies immunological test system.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 8 2012-04-01 2012-04-01 false Multiple autoantibodies immunological test system. 866.5660 Section 866.5660 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES IMMUNOLOGY AND MICROBIOLOGY DEVICES Immunological Test Systems §...

  3. 21 CFR 866.5660 - Multiple autoantibodies immunological test system.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 8 2014-04-01 2014-04-01 false Multiple autoantibodies immunological test system. 866.5660 Section 866.5660 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES IMMUNOLOGY AND MICROBIOLOGY DEVICES Immunological Test Systems §...

  4. 21 CFR 866.5660 - Multiple autoantibodies immunological test system.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 8 2011-04-01 2011-04-01 false Multiple autoantibodies immunological test system. 866.5660 Section 866.5660 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES IMMUNOLOGY AND MICROBIOLOGY DEVICES Immunological Test Systems §...

  5. MULTIPLE PROJECTIONS SYSTEM (MPS) - USER'S MANUAL VERSION 1.0

    EPA Science Inventory

    The report is a user's manual for version 1.0 of the Multiple Projections Systems (MPS), a computer system that can perform "what if" scenario analysis and report the final results (i.e., Rate of Further Progress - ROP - inventories) to EPA (i.e., the Aerometric Information Retri...

  6. Prototype microprocessor controller. [for STDN antennas

    NASA Technical Reports Server (NTRS)

    Zarur, J.; Kraeuter, R.

    1980-01-01

    A microcomputer controller for STDN antennas was developed. The microcomputer technology reduces the system's physical size by the implementation in firmware of functions. The reduction in the number of components increases system reliability and similar benefit is derived when a graphic video display is substituted for several control and indicator panels. A substantial reduction in the number of cables, connectors, and mechanical switches is achieved. The microcomputer based system is programmed to perform calibration and diagnostics, to update the satellite orbital vector, and to communicate with other network systems. The design is applicable to antennas and lasers.

  7. Transient thermal management comparison of a microprocessor using PCMs in various configurations

    NASA Astrophysics Data System (ADS)

    Thenmozhi, R.; Sharmeela, C.; Natarajan, P.; Velraj, R.

    2011-12-01

    There has been a strong interest in the use of Phase Change Materials (PCMs) for the transient thermal abatement of high powered microprocessor. This paper presents a set of transient computational analysis for selected IC packages with the purpose of calibrating the merits of PCM in different configurations. The transient analysis of high powered microprocessors with heat sinks was performed as a benchmark for comparison with the same microprocessors fitted with PCM in the following configurations: a) PCM imbedded into the finned region of the heat sink, b) PCM mounted between the microprocessor and heat sink, c) sealed PCM underfill to the microprocessor and d) PCM fitted to the underside of the printed circuit board directly beneath the microprocessor. The analysis was performed using a commercial CFD tool together with an approximation to the phase change mechanism using the slope method. Results indicate the merit of each configuration.

  8. Microprocessor-based controller for automatic amorphous silicon solar cells characterization

    SciTech Connect

    Cibils, R.M.; Buitrago, R.H.

    1984-07-01

    This work describes an innovation of traditional systems used in C--V and G--V curve measurements. Although this system has been specifically developed to be used in the characterization of hydrogenated amorphous silicon (a-Si:H), it is useful when information about conductance (G) or capacitance (C) frequency dependence is needed. The highlights of the new system are signal heterodination and microprocessor-based digital control over current range and modulation frequency. The outstanding advantages of this system are significant reduction of operation time and more reliable measurements. Additionally, there is no waste of computer time in the control of data-acquisition operations. The system has an excellent signal-to-noise ratio, a nearly infinite line signal rejection, and a broad frequency range of operation (20 to 10/sup 5/ Hz).

  9. Module comprising IC memory stack dedicated to and structurally combined with an IC microprocessor chip

    NASA Technical Reports Server (NTRS)

    Carson, John C. (Inventor); Indin, Ronald J. (Inventor); Shanken, Stuart N. (Inventor)

    1994-01-01

    A computer module is disclosed in which a stack of glued together IC memory chips is structurally integrated with a microprocessor chip. The memory provided by the stack is dedicated to the microprocessor chip. The microprocessor and its memory stack may be connected either by glue and/or by solder bumps. The solder bumps can perform three functions--electrical interconnection, mechanical connection, and heat transfer. The electrical connections in some versions are provided by wire bonding.

  10. Multiple sex chromosome systems in howler monkeys (Platyrrhini, Alouatta)

    PubMed Central

    Steinberg, Eliana Ruth; Nieves, Mariela; Mudry, Marta Dolores

    2014-01-01

    Abstract In light of the multiple sex chromosome systems observed in howler monkeys (Alouatta Lacépède, 1799) a combined cladistic analysis using chromosomal and molecular characters was applied to discuss the possible origin of these systems. Mesoamerican and South American howlers were karyologically compared. FISH analysis using the chromosome painting probes for the #3 and #15 human chromosomes was applied to corroborate the homeology of the sexual systems. We found that the HSA3/15 syntenic association, present in the sex chromosome systems of South American Howlers, is not present in those of Mesoamerican ones. The autosomes involved in the translocation that formed the sexual systems in the Mesoamerican and South American species are different, thus suggesting an independent origin. Parsimony analysis resolved the phylogenetic relationships among howler species, demonstrating utility of the combined approach. A hypothesis for the origin of the multiple sex chromosome systems for the genus is proposed. PMID:24744833

  11. Progressive Retinal Structure Abnormalities in Multiple System Atrophy

    PubMed Central

    Mendoza-Santiesteban, Carlos E.; Palma, Jose-Alberto; Martinez, Jose; Norcliffe-Kaufmann, Lucy; Hedges, Thomas R.; Kaufmann, Horacio

    2015-01-01

    Background Objective measures of disease progression that can be used as end-points in clinical trials of multiple system atrophy are necessary. We studied retinal thickness in patients with multiple system atrophy, and assessed changes over time to determine its usefulness as imaging biomarker of disease progression. Methods Cross sectional study including 24 patients with multiple system atrophy, 20 patients with Parkinson disease (PD) and 35 controls; followed by a longitudinal study of 13 multiple system atrophy (MSA) patients. Patients were evaluated with high definition-optical coherence tomography and the Unified Multiple System Atrophy Rating Scale. Evaluations were performed at baseline and at consecutive follow-up visits for up to 26 months. Results MSA subjects had normal visual acuity and color discrimination. Compared to controls, retinal nerve fiber layer (p=0.008 and p=0.001) and ganglion cell complex (p=0.013 and p=0.001) thicknesses were reduced in multiple system atrophy and in PD. No significant differences between MSA and PD were found. Over time, in patients with MSA, there was a significant reduction of the retinal nerve fiber layer and ganglion cell complex thicknesses, with estimated annual average losses of 3.7 μm and 1.8 μm respectively. Conclusions Visually asymptomatic MSA patients exhibit progressive reductions in the thickness of the retinal nerve fiber layer and, to a lesser extent, in the macular ganglion cell complex, which can be quantified by high-definition optical coherence tomography. Specific patterns of retinal nerve fiber damage could be a useful imaging biomarker of disease progression in future clinical trials. PMID:26359930

  12. Multiple-User, Multitasking, Virtual-Memory Computer System

    NASA Technical Reports Server (NTRS)

    Generazio, Edward R.; Roth, Don J.; Stang, David B.

    1993-01-01

    Computer system designed and programmed to serve multiple users in research laboratory. Provides for computer control and monitoring of laboratory instruments, acquisition and anlaysis of data from those instruments, and interaction with users via remote terminals. System provides fast access to shared central processing units and associated large (from megabytes to gigabytes) memories. Underlying concept of system also applicable to monitoring and control of industrial processes.

  13. Multiple-state quantum Otto engine, 1D box system

    NASA Astrophysics Data System (ADS)

    Latifah, E.; Purwanto, A.

    2014-03-01

    Quantum heat engines produce work using quantum matter as their working substance. We studied adiabatic and isochoric processes and defined the general force according to quantum system. The processes and general force are used to evaluate a quantum Otto engine based on multiple-state of one dimensional box system and calculate the efficiency. As a result, the efficiency depends on the ratio of initial and final width of system under adiabatic processes.

  14. Multiple-state quantum Otto engine, 1D box system

    SciTech Connect

    Latifah, E.; Purwanto, A.

    2014-03-24

    Quantum heat engines produce work using quantum matter as their working substance. We studied adiabatic and isochoric processes and defined the general force according to quantum system. The processes and general force are used to evaluate a quantum Otto engine based on multiple-state of one dimensional box system and calculate the efficiency. As a result, the efficiency depends on the ratio of initial and final width of system under adiabatic processes.

  15. System For Research On Multiple-Arm Robots

    NASA Technical Reports Server (NTRS)

    Backes, Paul G.; Hayati, Samad; Tso, Kam S.; Hayward, Vincent

    1991-01-01

    Kali system of computer programs and equipment provides environment for research on distributed programming and distributed control of coordinated-multiple-arm robots. Suitable for telerobotics research involving sensing and execution of low level tasks. Software and configuration of hardware designed flexible so system modified easily to test various concepts in control and programming of robots, including multiple-arm control, redundant-arm control, shared control, traded control, force control, force/position hybrid control, design and integration of sensors, teleoperation, task-space description and control, methods of adaptive control, control of flexible arms, and human factors.

  16. Systemic Multiple Aneurysms Caused by Vascular Ehlers-Danlos Syndrome.

    PubMed

    Gui, Xinyu; Li, Fangda; Wu, Lingeer; Zheng, Yuehong

    2016-07-01

    Systemic multiple aneurysms are rare and usually associated with collagen tissue disease, such as Ehlers-Danlos syndrome (EDS) or Marfan syndrome. In the present case, we describe a 39-year-old male patient with systemic multiple aneurysms and acute intraperitoneal hemorrhage who was clinically diagnosed with vascular EDS. Coil embolization of the distal segment of the common hepatic artery was performed, which resolved the patient's symptoms. With this case presentation, we aim to increase the awareness of vascular EDS among clinicians and emphasize the extreme fragility of the arteries in patients with vascular EDS.

  17. FAME, a microprocessor based front-end analysis and modeling environment

    NASA Technical Reports Server (NTRS)

    Rosenbaum, J. D.; Kutin, E. B.

    1980-01-01

    Higher order software (HOS) is a methodology for the specification and verification of large scale, complex, real time systems. The HOS methodology was implemented as FAME (front end analysis and modeling environment), a microprocessor based system for interactively developing, analyzing, and displaying system models in a low cost user-friendly environment. The nature of the model is such that when completed it can be the basis for projection to a variety of forms such as structured design diagrams, Petri-nets, data flow diagrams, and PSL/PSA source code. The user's interface with the analyzer is easily recognized by any current user of a structured modeling approach; therefore extensive training is unnecessary. Furthermore, when all the system capabilities are used one can check on proper usage of data types, functions, and control structures thereby adding a new dimension to the design process that will lead to better and more easily verified software designs.

  18. The application of the ADSP-21020 40-bit floating point DSP microprocessor in a digital Doppler radar

    SciTech Connect

    Robinson, S.H.; Morrison, R.E.

    1991-08-26

    A continuous wave doppler radar system has been designed which is portable, easily deployable and can be remotely controlled. The system is immune to ground clutter and is used for wind speed detection and direction determination. Nearly real time digital signal processing is performed by an Analog Devices ADSP-21020, a 40-bit floating point Digital Signal Processing (DSP) microprocessor. This paper provides an overview of the design of the system including the radio frequency (RF) to digital interface. The various DSP detection algorithms are discussed and compared to system performance and sensitivity. Finally, DSP performance is compared to the performance of an earlier system using Analog Device's ADSP-2100. 6 refs.

  19. Identifying The Ejected Population From Disintegrating Multiple Systems

    NASA Astrophysics Data System (ADS)

    Yip, Alexandra Ka Po; Pinfield, David J.; Kurtev, Radostin; Gromadzki, Mariusz; Marocco, Federico

    2016-08-01

    Kinematic studies of the Hipparcos catalogue have revealed associations that are best explained as disintegrating multiple systems, presumably resulting from a dynamical encounter between single/multiple systems in the field (Li et al., 2009). In this work we explore the possibility that known ultra-cool dwarfs may be components of disintegrating multiple systems, and consider the implications for the properties of these objects. We will present here the methods/techniques that can be used to search for and identify disintegrating benchmark systems in three database/catalogues: Dwarf Archive, the Hipparcos Main Catalogue, and the Gliese-Jahreiszlig; Catalogue. Placing distance constraints on objects with parallax or colour-magnitude information from spectrophotometry allowed us to identify common distance associations. Proper motion measurements allowed us to separate common proper motion multiples from our sample of disintegrating candidates. Moreover, proper motion and positional information allowed us to select candidate systems based on relative component positions that were tracked back and projected forward through time. Using this method we identified one candidate disintegrating quadruple association, and two candidate disintegrating binaries, all of them containing one ultra-cool dwarf.

  20. Time-delay identification for vibration systems with multiple feedback

    NASA Astrophysics Data System (ADS)

    Sun, Yi-Qiang; Jin, Meng-Shi; Song, Han-Wen; Xu, Jian

    2016-12-01

    An approach for time-delay identification is proposed in multiple-degree-of-freedom (MDOF) linear systems with multiple feedback. The applicability of the approach is discussed in detail. Based on the characteristics of frequency domain in feedback controlled system with multiple time-delays, this paper proposes a time-delay identification approach, which is based on the pseudo impedance function of reference point. Treating feedback time-delays as the "frequencies" of the oscillation curve, the time-delays can be obtained from the "frequencies" of the curve. Numerical simulation is conducted to validate the proposed approach. The application scope of the approach is discussed with regard to different forms of feedback.

  1. Using reconfigurable functional units in conventional microprocessors.

    SciTech Connect

    Rodrigues, Arun F.

    2010-09-01

    Scientific applications use highly specialized data structures that require complex, latency sensitive graphs of integer instructions for memory address calculations. Working with the Univeristy of Wisconsin, we have demonstrated significant differences between the Sandia's applications and the industry standard SPEC-FP (standard performance evaluation corporation-floating point) suite. Specifically, integer dataflow performance is critical to overall system performance. To improve this performance, we have developed a configurable functional unit design that is capable of accelerating integer dataflow.

  2. A Microprocessor Controlled Autonomous Sentry Robot.

    DTIC Science & Technology

    1982-10-01

    plate is electrically insulated from the ver- tical pole which serves as the GND connection by a plexi - glass insulator between the plate and the...Figure 9. A considerable amount of frictional damping is inherently present in this positioning system, which decreases ,the chances of overshoot...on the prototype: simply ignore the near-infrared proximity detectors. An even better plan would call for reducing the receiver sensitivity by a factor

  3. Microprocessor-based multichannel flutter monitor using dynamic strain gage signals

    NASA Technical Reports Server (NTRS)

    Smalley, R. R.

    1976-01-01

    Two microprocessor-based multichannel monitors for monitoring strain gage signals during aerodynamic instability (flutter) testing in production type turbojet engines were described. One system monitors strain gage signals in the time domain and gives an output indication whenever the signal amplitude of any gage exceeds a pre-set alarm or abort level for that particular gage. The second system monitors the strain gage signals in the frequency domain and therefore is able to use both the amplitude and frequency information. Thus, an alarm signal is given whenever the spectral content of the strain gage signal exceeds, at any point, its corresponding amplitude vs. frequency limit profiles. Each system design is described with details on design trade-offs, hardware, software, and operating experience.

  4. The DIII-D ECH multiple gyrotron control system

    SciTech Connect

    Ponce, D.; Lohr, J.; Tooker, J.F.; Cary, W.P.; Harris, T.E.

    1997-11-01

    DIII-D`s ECH upgrade with 1 MW, 110 GHz gyrotrons is ongoing, and with it, an upgrade of the control system. The ECH Multiple Gyrotron Control System uses software distributed among networked computers, interfaced to a programmable logic controller (PLC), the timing and pulse system, power supplies, vacuum and wave guide controls, and instrumentation. During DIII-D operations, the system will allow a chief and a co-operator to control and monitor a number of gyrotrons from different manufacturers. The software, written using LabVIEW, allows for remote and multiple operator control. Thus any supported computer can become a control station and multiple projects can be simultaneously accommodated. Each operator can be given access to the controls of all gyrotrons or to a subset of controls. Status information is also remotely available. The use of a PLC simplifies the hardware and software design. It reduces interlock and control circuitry, includes monitoring for slow analog signals, and allows one software driver to efficiently interface to a number of systems. In addition, the interlock logic can be easily changed and control points can be forced as needed. The pulse system is designed around arbitrary function generators. Various modulation schemes can be accommodated, including real-time control of the modulation. This discussion will include the hardware and software design of the control system and its current implementation.

  5. (3749) BALAM: A VERY YOUNG MULTIPLE ASTEROID SYSTEM

    SciTech Connect

    Vokrouhlicky, David

    2009-11-20

    Binaries and multiple systems among small bodies in the solar system have received wide attention over the past decade. This is because their observations provide a wealth of data otherwise inaccessible for single objects. We use numerical integration to prove that the multiple asteroid system (3749) Balam is very young, in contrast to its previously assumed age of 0.5-1 Gyr related to the formation of the Flora family. This work is enabled by a fortuitous discovery of a paired component to (3749) Balam. We first show that the proximity of the (3749) Balam and 2009 BR60 orbits is not a statistical fluke of otherwise quasi-uniform distribution. Numerical integrations then strengthen the case and allow us to prove that 2009 BR60 separated from the Balam system less than a million years ago. This is the first time the age of a binary asteroid can be estimated with such accuracy.

  6. Building a cognitive map by assembling multiple path integration systems.

    PubMed

    Wang, Ranxiao Frances

    2016-06-01

    Path integration and cognitive mapping are two of the most important mechanisms for navigation. Path integration is a primitive navigation system which computes a homing vector based on an animal's self-motion estimation, while cognitive map is an advanced spatial representation containing richer spatial information about the environment that is persistent and can be used to guide flexible navigation to multiple locations. Most theories of navigation conceptualize them as two distinctive, independent mechanisms, although the path integration system may provide useful information for the integration of cognitive maps. This paper demonstrates a fundamentally different scenario, where a cognitive map is constructed in three simple steps by assembling multiple path integrators and extending their basic features. The fact that a collection of path integration systems can be turned into a cognitive map suggests the possibility that cognitive maps may have evolved directly from the path integration system.

  7. Designs and performance of microprocessor-controlled knee joints.

    PubMed

    Thiele, Julius; Westebbe, Bettina; Bellmann, Malte; Kraft, Marc

    2014-02-01

    In this comparative study, three transfemoral amputee subjects were fitted with four different microprocessor-controlled exoprosthetic knee joints (MPK): C-Leg, Orion, Plié2.0, and Rel-K. In a motion analysis laboratory, objective gait measures were acquired during level walking at different velocities. Subsequent technical analyses, which involved X-ray computed tomography, identified the functional mechanisms of each device and enabled corroboration of the performance in the gait laboratory by the engineering design of the MPK. Gait measures showed that the mean increase of the maximum knee flexion angle at different walking velocities was closest in value to the unaffected contralateral knee (6.2°/m/s) with C-Leg (3.5°/m/s; Rel-K 17.0°/m/s, Orion 18.3°/m/s, and Plié2.0 28.1°/m/s). Technical analyses corroborated that only with Plié2.0 the flexion resistances were not regulated by microprocessor control at different walking velocities. The muscular effort for the initiation of the swing phase, measured by the minimum hip moment, was found to be lowest with C-Leg (-82.1±14.1 Nm; Rel-K -83.59±17.8 Nm, Orion -88.0±16.3 Nm, and Plié2.0 -91.6±16.5 Nm). Reaching the extension stop at the end of swing phase was reliably executed with both Plié2.0 and C-Leg. Abrupt terminal stance phase extension observed with Plié2.0 and Rel-K could be attributed to the absence of microprocessor control of extension resistance.

  8. System configured for applying multiple modifying agents to a substrate

    DOEpatents

    Propp, W. Alan; Argyle, Mark D.; Janikowski, Stuart K.; Fox, Robert V.; Toth, William J.; Ginosar, Daniel M.; Allen, Charles A.; Miller, David L.

    2003-11-25

    The present invention is related to the modifying of substrates with multiple modifying agents in a single continuous system. At least two processing chambers are configured for modifying the substrate in a continuous feed system. The processing chambers can be substantially isolated from one another by interstitial seals. Additionally, the two processing chambers can be substantially isolated from the surrounding atmosphere by end seals. Optionally, expansion chambers can be used to separate the seals from the processing chambers.

  9. NEXT Propellant Management System Integration With Multiple Ion Thrusters

    NASA Technical Reports Server (NTRS)

    Sovey, James S.; Soulas, George C.; Herman, Daniel A.

    2011-01-01

    As a critical part of the NEXT test validation process, a multiple-string integration test was performed on the NEXT propellant management system and ion thrusters. The objectives of this test were to verify that the PMS is capable of providing stable flow control to multiple thrusters operating over the NEXT system throttling range and to demonstrate to potential users that the NEXT PMS is ready for transition to flight. A test plan was developed for the sub-system integration test for verification of PMS and thruster system performance and functionality requirements. Propellant management system calibrations were checked during the single and multi-thruster testing. The low pressure assembly total flow rates to the thruster(s) were within 1.4 percent of the calibrated support equipment flow rates. The inlet pressures to the main, cathode, and neutralizer ports of Thruster PM1R were measured as the PMS operated in 1-thruster, 2-thruster, and 3-thruster configurations. It was found that the inlet pressures to Thruster PM1R for 2-thruster and 3-thruster operation as well as single thruster operation with the PMS compare very favorably indicating that flow rates to Thruster PM1R were similar in all cases. Characterizations of discharge losses, accelerator grid current, and neutralizer performance were performed as more operating thrusters were added to the PMS. There were no variations in these parameters as thrusters were throttled and single and multiple thruster operations were conducted. The propellant management system power consumption was at a fixed voltage to the DCIU and a fixed thermal throttle temperature of 75 C. The total power consumed by the PMS was 10.0, 17.9, and 25.2 W, respectively, for single, 2-thruster, and 3-thruster operation with the PMS. These sub-system integration tests of the PMS, the DCIU Simulator, and multiple thrusters addressed, in part, the NEXT PMS and propulsion system performance and functionality requirements.

  10. System Configured For Applying Multiple Modifying Agents To A Substrate.

    DOEpatents

    Propp, W. Alan; Argyle, Mark D.; Janikowski, Stuart K.; Fox, Robert V.; Toth, William J.; Ginosar, Daniel M.; Allen, Charles A.; Miller, David L.

    2005-11-08

    The present invention is related to the modifying of substrates with multiple modifying agents in a single continuous system. At least two processing chambers are configured for modifying the substrate in a continuous feed system. The processing chambers can be substantially isolated from one another by interstitial seals. Additionally, the two processing chambers can be substantially isolated from the surrounding atmosphere by end seals. Optionally, expansion chambers can be used to separate the seals from the processing chambers.

  11. Multiple-etalon systems for the Advanced Technology Solar Telescope

    NASA Technical Reports Server (NTRS)

    Gary, G. Allen; Balasubramaniam, K. S.; Sigwarth, Michael

    2003-01-01

    Multiple etalon systems are discussed that meet the science requirements for a narrow-passband imaging system for the 4-meter National Solar Observatory (NSO)/Advance Technology Solar Telescope (ATST). A multiple etalon system can provide an imaging interferometer that works in four distinct modes: as a spectro-polarimeter, a filter-vector magnetograph, an intermediate-band imager, and broadband high-resolution imager. Specific dual and triple etalon configurations are described that provide a spectrographic passband of 2.0-3.5 micron and reduce parasitic light levels to 10(exp -4) as required for precise polarization measurement, e.g., Zeeman measurements of magnetic sensitive lines. A TESOS-like (Telecentric Etalon SOlar Spectrometer) triple etalon system provides a spectral purity of 10(exp -5). The triple designs have the advantage of reducing the finesse requirement on each etalon; allow the use of more stable blocking filters, and have very high spectral purity. A dual-etalon double-pass (Cavallini-like) system can provide a competing configuration. Such a dual-etalon design can provide high contrast. The selection of the final focal plane instrument will depend on a trade-off between an ideal instrument and practical reality. The trade study will include the number of etalons, their aperture sizes, complexities of the optical train, number of blocking filters, configuration of the electronic control system, computer interfaces, temperature controllers, etalon controllers, and their associated feedback electronics. The heritage of single and multiple etalon systems comes from their use in several observatories, including the Marshall Space Flight Center (MSFC) Solar Observatory, Sacramento Peak Observatory (NSO), and Kiepenheuer-Institut fur Sonnenphysik (KIS, Germany), Mees Solar Observatory (University of Hawaii), and Arcetri Astrophysical Observatory (Italy). The design of the ATST multiple etalon system will benefit from the experience gained at these

  12. SystemVerilog-Based Verification Environment Employing Multiple Inheritance of SystemC

    NASA Astrophysics Data System (ADS)

    You, Myoung-Keun; Song, Gi-Yong

    In this paper, we describe a verification environment which is based on a constrained random layered testbench using SystemVerilog OOP. As SystemVerilog OOP technique does not allow multiple inheritance, we adopt SystemC to design components of a verification environment which employ multiple inheritance. Then SystemC design unit is linked to a SystemVerilog-based verification environment using SystemVerilog DPI and ModelSim macro. Employing multiple inheritance of SystemC makes the design phase of verification environment simple and easy through source code reusability without corruption due to multi-level single inheritance.

  13. The Capacity Gain of Orbital Angular Momentum Based Multiple-Input-Multiple-Output System

    NASA Astrophysics Data System (ADS)

    Zhang, Zhuofan; Zheng, Shilie; Chen, Yiling; Jin, Xiaofeng; Chi, Hao; Zhang, Xianmin

    2016-05-01

    Wireless communication using electromagnetic wave carrying orbital angular momentum (OAM) has attracted increasing interest in recent years, and its potential to increase channel capacity has been explored widely. In this paper, we compare the technique of using uniform linear array consist of circular traveling-wave OAM antennas for multiplexing with the conventional multiple-in-multiple-out (MIMO) communication method, and numerical results show that the OAM based MIMO system can increase channel capacity while communication distance is long enough. An equivalent model is proposed to illustrate that the OAM multiplexing system is equivalent to a conventional MIMO system with a larger element spacing, which means OAM waves could decrease the spatial correlation of MIMO channel. In addition, the effects of some system parameters, such as OAM state interval and element spacing, on the capacity advantage of OAM based MIMO are also investigated. Our results reveal that OAM waves are complementary with MIMO method. OAM waves multiplexing is suitable for long-distance line-of-sight (LoS) communications or communications in open area where the multi-path effect is weak and can be used in massive MIMO systems as well.

  14. The Capacity Gain of Orbital Angular Momentum Based Multiple-Input-Multiple-Output System

    PubMed Central

    Zhang, Zhuofan; Zheng, Shilie; Chen, Yiling; Jin, Xiaofeng; Chi, Hao; Zhang, Xianmin

    2016-01-01

    Wireless communication using electromagnetic wave carrying orbital angular momentum (OAM) has attracted increasing interest in recent years, and its potential to increase channel capacity has been explored widely. In this paper, we compare the technique of using uniform linear array consist of circular traveling-wave OAM antennas for multiplexing with the conventional multiple-in-multiple-out (MIMO) communication method, and numerical results show that the OAM based MIMO system can increase channel capacity while communication distance is long enough. An equivalent model is proposed to illustrate that the OAM multiplexing system is equivalent to a conventional MIMO system with a larger element spacing, which means OAM waves could decrease the spatial correlation of MIMO channel. In addition, the effects of some system parameters, such as OAM state interval and element spacing, on the capacity advantage of OAM based MIMO are also investigated. Our results reveal that OAM waves are complementary with MIMO method. OAM waves multiplexing is suitable for long-distance line-of-sight (LoS) communications or communications in open area where the multi-path effect is weak and can be used in massive MIMO systems as well. PMID:27146453

  15. The Capacity Gain of Orbital Angular Momentum Based Multiple-Input-Multiple-Output System.

    PubMed

    Zhang, Zhuofan; Zheng, Shilie; Chen, Yiling; Jin, Xiaofeng; Chi, Hao; Zhang, Xianmin

    2016-05-05

    Wireless communication using electromagnetic wave carrying orbital angular momentum (OAM) has attracted increasing interest in recent years, and its potential to increase channel capacity has been explored widely. In this paper, we compare the technique of using uniform linear array consist of circular traveling-wave OAM antennas for multiplexing with the conventional multiple-in-multiple-out (MIMO) communication method, and numerical results show that the OAM based MIMO system can increase channel capacity while communication distance is long enough. An equivalent model is proposed to illustrate that the OAM multiplexing system is equivalent to a conventional MIMO system with a larger element spacing, which means OAM waves could decrease the spatial correlation of MIMO channel. In addition, the effects of some system parameters, such as OAM state interval and element spacing, on the capacity advantage of OAM based MIMO are also investigated. Our results reveal that OAM waves are complementary with MIMO method. OAM waves multiplexing is suitable for long-distance line-of-sight (LoS) communications or communications in open area where the multi-path effect is weak and can be used in massive MIMO systems as well.

  16. On the Floating Point Performance of the i860 Microprocessor

    NASA Technical Reports Server (NTRS)

    Lee, King; Kutler, Paul (Technical Monitor)

    1997-01-01

    The i860 microprocessor is a pipelined processor that can deliver two double precision floating point results every clock. It is being used in the Touchstone project to develop a teraflop computer by the year 2000. With such high computational capabilities it was expected that memory bandwidth would limit performance on many kernels. Measured performance of three kernels showed performance is less than what memory bandwidth limitations would predict. This paper develops a model that explains the discrepancy in terms of memory latencies and points to some problems involved in moving data from memory to the arithmetic pipelines.

  17. Multiple Etalon Systems for the Advanced Technology Solar Telescope

    NASA Technical Reports Server (NTRS)

    Gary, G. Allen; Balasubramaniam, K. S.; Sigwarth, Michael; Six, N. Frank (Technical Monitor)

    2002-01-01

    Multiple etalons systems are discussed that meet the 4-meter NSO/Advance Technology Solar Telescope (http://www.nso.edu/ATST/index.html) instrument and science requirements for a narrow bandpass imaging system. A multiple etalon system can provide an imaging interferometer working in four distinct modes: as a spectro-polarimeter, a filter-vector magnetograph, and a wide-band and broad-band high-resolution imager. Specific dual and triple etalon configurations will be described that provides spectrographic passband of 2.0-3.5nm and reduces parasitic light levels to 1/10000 as required by precise polarization measurement, e.g., Zeeman measurements of magnetic sensitive lines. A TESOS-like triple etalon system provides for spectral purity of 100 thousandths. The triple designs have the advantage of reducing the finesse requirement on each etalon, allowing much more stable blocking filters, and can have very high spectral purity. A dual-etalon double-pass Cavallini-like configuration can provide a competing configuration. This design can provide high contrast with only a double etalon. The selection of the final focal plan instrument will depend on a trade-off of the ideal instrument versus reality, the number of etalons, the aperture of etalons, the number of blocking filters the electronic control system and computer interfaces, the temperature control and controllers for the etalons and the electronics. The use of existing experience should provide significant cost savings. The heritage of use of etalons and multiple etalon systems in solar physics come from a number of observatories, which includes MSFC Solar Observatory (NASA), Sac Peak Observatory (NSO), and Kiepenheuer Institute for Solar Physics (Germany), Mees Solar Observatory (University of Hawaii), and Arcetri Astrophysical Observatory (Italy). The design of the ATST multiple etalon system will reply on the existing experience from these observatories.

  18. Precision Control of Multiple Quantum Cascade Lasers for Calibration Systems

    SciTech Connect

    Taubman, Matthew S.; Myers, Tanya L.; Pratt, Richard M.; Stahl, Robert D.; Cannon, Bret D.

    2014-01-15

    We present a precision, digitally interfaced current controller for quantum cascade lasers, with demonstrated DC and modulated temperature coefficients of 1- 2 ppm/ºC and 15 ppm/ºC respectively. High linearity digital to analog converters (DACs) together with an ultra-precision voltage reference, produce highly stable, precision voltages. These are in turn selected by a low charge-injection multiplexer (MUX) chip, which are then used to set output currents via a linear current regulator. The controller is operated in conjunction with a power multiplexing unit, allowing one of three lasers to be driven by the controller while ensuring protection of controller and all lasers during operation, standby and switching. Simple ASCII commands sent over a USB connection to a microprocessor located in the current controller operate both the controller (via the DACs and MUX chip) and the power multiplexer.

  19. Precision control of multiple quantum cascade lasers for calibration systems

    SciTech Connect

    Taubman, Matthew S. Myers, Tanya L.; Pratt, Richard M.; Stahl, Robert D.; Cannon, Bret D.

    2014-01-15

    We present a precision, 1-A, digitally interfaced current controller for quantum cascade lasers, with demonstrated temperature coefficients for continuous and 40-kHz full-depth square-wave modulated operation, of 1–2 ppm/ °C and 15 ppm/ °C, respectively. High precision digital to analog converters (DACs) together with an ultra-precision voltage reference produce highly stable, precision voltages, which are selected by a multiplexer (MUX) chip to set output currents via a linear current regulator. The controller is operated in conjunction with a power multiplexing unit, allowing one of three lasers to be driven by the controller, while ensuring protection of controller and all lasers during operation, standby, and switching. Simple ASCII commands sent over a USB connection to a microprocessor located in the current controller operate both the controller (via the DACs and MUX chip) and the power multiplexer.

  20. A floating-point/multiple-precision processor for airborne applications

    NASA Technical Reports Server (NTRS)

    Yee, R.

    1982-01-01

    A compact input output (I/O) numerical processor capable of performing floating-point, multiple precision and other arithmetic functions at execution times which are at least 100 times faster than comparable software emulation is described. The I/O device is a microcomputer system containing a 16 bit microprocessor, a numerical coprocessor with eight 80 bit registers running at a 5 MHz clock rate, 18K random access memory (RAM) and 16K electrically programmable read only memory (EPROM). The processor acts as an intelligent slave to the host computer and can be programmed in high order languages such as FORTRAN and PL/M-86.

  1. Development of Multiple-Frequency Ultrasonic Imaging System Using Multiple Resonance Piezoelectric Transducer

    NASA Astrophysics Data System (ADS)

    Akiyama, Iwaki; Yoshizumi, Natsuki; Saito, Shigemi; Wada, Yuji; Koyama, Daisuke; Nakamura, Kentaro

    2012-07-01

    The authors have developed a multiple frequency imaging system using a multiple resonance transducer (MRT) consisting of 1-3 composite materials with a low mechanical quality factor Q bonded together. The MRT has a structure consisting of thin and thick piezoelectric plates, two matching layers, and a backing layer. This makes it possible to obtain B-mode images of satisfactory resolution using ultrasonic pulses owing to their short duration. In this paper, the vibration property of the MRT derived through equivalent-circuit analysis is first shown. By utilizing the result, an MRT capable of transmitting ultrasonic pulses for generation of the images of biological tissues with satisfactory resolution is designed and prototyped. Setting the prototype transducer in the mechanical sector probe of commercial ultrasonic diagnosis equipment, the speckle reduction effect is demonstrated using images of various phantoms to mimic biological tissues and a human thyroid.

  2. Galerkin projection methods for solving multiple related linear systems

    SciTech Connect

    Chan, T.F.; Ng, M.; Wan, W.L.

    1996-12-31

    We consider using Galerkin projection methods for solving multiple related linear systems A{sup (i)}x{sup (i)} = b{sup (i)} for 1 {le} i {le} s, where A{sup (i)} and b{sup (i)} are different in general. We start with the special case where A{sup (i)} = A and A is symmetric positive definite. The method generates a Krylov subspace from a set of direction vectors obtained by solving one of the systems, called the seed system, by the CG method and then projects the residuals of other systems orthogonally onto the generated Krylov subspace to get the approximate solutions. The whole process is repeated with another unsolved system as a seed until all the systems are solved. We observe in practice a super-convergence behaviour of the CG process of the seed system when compared with the usual CG process. We also observe that only a small number of restarts is required to solve all the systems if the right-hand sides are close to each other. These two features together make the method particularly effective. In this talk, we give theoretical proof to justify these observations. Furthermore, we combine the advantages of this method and the block CG method and propose a block extension of this single seed method. The above procedure can actually be modified for solving multiple linear systems A{sup (i)}x{sup (i)} = b{sup (i)}, where A{sup (i)} are now different. We can also extend the previous analytical results to this more general case. Applications of this method to multiple related linear systems arising from image restoration and recursive least squares computations are considered as examples.

  3. Ambulatory REACT: real-time seizure detection with a DSP microprocessor.

    PubMed

    McEvoy, Robert P; Faul, Stephen; Marnane, William P

    2010-01-01

    REACT (Real-Time EEG Analysis for event deteCTion) is a Support Vector Machine based technology which, in recent years, has been successfully applied to the problem of automated seizure detection in both adults and neonates. This paper describes the implementation of REACT on a commercial DSP microprocessor; the Analog Devices Blackfin®. The primary aim of this work is to develop a prototype system for use in ambulatory or in-ward automated EEG analysis. Furthermore, the complexity of the various stages of the REACT algorithm on the Blackfin processor is analysed; in particular the EEG feature extraction stages. This hardware profile is used to select a reduced, platform-aware feature set, in order to evaluate the seizure classification accuracy of a lower-complexity, lower-power REACT system.

  4. Distributed magnetic field positioning system using code division multiple access

    NASA Technical Reports Server (NTRS)

    Prigge, Eric A. (Inventor)

    2003-01-01

    An apparatus and methods for a magnetic field positioning system use a fundamentally different, and advantageous, signal structure and multiple access method, known as Code Division Multiple Access (CDMA). This signal architecture, when combined with processing methods, leads to advantages over the existing technologies, especially when applied to a system with a large number of magnetic field generators (beacons). Beacons at known positions generate coded magnetic fields, and a magnetic sensor measures a sum field and decomposes it into component fields to determine the sensor position and orientation. The apparatus and methods can have a large `building-sized` coverage area. The system allows for numerous beacons to be distributed throughout an area at a number of different locations. A method to estimate position and attitude, with no prior knowledge, uses dipole fields produced by these beacons in different locations.

  5. Alternative multiple-access techniques for mobile satellite systems

    NASA Technical Reports Server (NTRS)

    Smith, Patrick O.; Geraniotis, Evaggelos

    1989-01-01

    The use of Code Division Multiple Access (CDMA) to satisfy the diverse requirements of a generic (land, maritime, aeronautical) mobile satellite system (MSS) network design is discussed. Comparisons between CDMA and Frequency Division Multiple Access (FDMA) show that a CDMA network design can support significantly more voice channel allocations than FDMA when relatively simple CDMA correlation receivers are employed, provided that there is sufficient space segment equivalent isotropically radiated power (EIRP). The use of more advanced CDMA receivers can improve the spectral and power efficiency. Although the use of CDMA may not gain immediate and widespread support in the international MSS community, provision for the use of CDMA for a domestic system in the U.S., and possibly for a regional system throughout North America, is likely.

  6. A Portable Farmland Information Collection System with Multiple Sensors

    PubMed Central

    Zhang, Jianfeng; Hu, Jinyang; Huang, Lvwen; Zhang, Zhiyong; Ma, Yimian

    2016-01-01

    Precision agriculture is the trend of modern agriculture, and it is also one of the important ways to realize the sustainable development of agriculture. In order to meet the production requirements of precision agriculture—efficient use of agricultural resources, and improving the crop yields and quality—some necessary field information in crop growth environment needs to be collected and monitored. In this paper, a farmland information collection system is developed, which includes a portable farmland information collection device based on STM32 (a 32-bit comprehensive range of microcontrollers based on ARM Crotex-M3), a remote server and a mobile phone APP. The device realizes the function of portable and mobile collecting of multiple parameters farmland information, such as chlorophyll content of crop leaves, air temperature, air humidity, and light intensity. UM220-III (Unicore Communication Inc., Beijing, China) is used to realize the positioning based on BDS/GPS (BeiDou Navigation Satellite System, BDS/Global Positioning System, GPS) dual-mode navigation and positioning system, and the CDMA (Code Division Multiple Access, CDMA) wireless communication module is adopted to realize the real-time remote transmission. The portable multi-function farmland information collection system is real-time, accurate, and easy to use to collect farmland information and multiple information parameters of crops. PMID:27782076

  7. A Portable Farmland Information Collection System with Multiple Sensors.

    PubMed

    Zhang, Jianfeng; Hu, Jinyang; Huang, Lvwen; Zhang, Zhiyong; Ma, Yimian

    2016-10-22

    Precision agriculture is the trend of modern agriculture, and it is also one of the important ways to realize the sustainable development of agriculture. In order to meet the production requirements of precision agriculture-efficient use of agricultural resources, and improving the crop yields and quality-some necessary field information in crop growth environment needs to be collected and monitored. In this paper, a farmland information collection system is developed, which includes a portable farmland information collection device based on STM32 (a 32-bit comprehensive range of microcontrollers based on ARM Crotex-M3), a remote server and a mobile phone APP. The device realizes the function of portable and mobile collecting of multiple parameters farmland information, such as chlorophyll content of crop leaves, air temperature, air humidity, and light intensity. UM220-III (Unicore Communication Inc., Beijing, China) is used to realize the positioning based on BDS/GPS (BeiDou Navigation Satellite System, BDS/Global Positioning System, GPS) dual-mode navigation and positioning system, and the CDMA (Code Division Multiple Access, CDMA) wireless communication module is adopted to realize the real-time remote transmission. The portable multi-function farmland information collection system is real-time, accurate, and easy to use to collect farmland information and multiple information parameters of crops.

  8. DEVELOPMENT OF A WIRELINE CPT SYSTEM FOR MULTIPLE TOOL USAGE

    SciTech Connect

    Stephen P. Farrington; Martin L. Gildea; J. Christopher Bianchi

    1999-08-01

    The first phase of development of a wireline cone penetrometer system for multiple tool usage was completed under DOE award number DE-AR26-98FT40366. Cone penetrometer technology (CPT) has received widespread interest and is becoming more commonplace as a tool for environmental site characterization activities at several Department of Energy (DOE) facilities. Although CPT already offers many benefits for site characterization, the wireline system can improve CPT technology by offering greater utility and increased cost savings. Currently the use of multiple CPT tools during a site characterization (i.e. piezometric cone, chemical sensors, core sampler, grouting tool) must be accomplished by withdrawing the entire penetrometer rod string to change tools. This results in multiple penetrations being required to collect the data and samples that may be required during characterization of a site, and to subsequently seal the resulting holes with grout. The wireline CPT system allows multiple CPT tools to be interchanged during a single penetration, without withdrawing the CPT rod string from the ground. The goal of the project is to develop and demonstrate a system by which various tools can be placed at the tip of the rod string depending on the type of information or sample desired. Under the base contract, an interchangeable piezocone and grouting tool was designed, fabricated, and evaluated. The results of the evaluation indicate that success criteria for the base contract were achieved. In addition, the wireline piezocone tool was validated against ASTM standard cones, the depth capability of the system was found to compare favorably with that of conventional CPT, and the reliability and survivability of the system were demonstrated.

  9. COED Transactions, Vol. IX, No. 6, June 1977. An Introductory Course in Microprocessors and Microcomputers.

    ERIC Educational Resources Information Center

    Marcovitz, Alan B., Ed.

    This paper describes an introductory course in microprocessors and microcomputers implemented at Grossmont College. The current state-of-the-art in the microprocessor field is discussed, with special emphasis on the 8-bit MOS single-chip processors which are the most commonly used devices. Objectives and guidelines for the course are presented,…

  10. Expanding the spectrum of neuronal pathology in multiple system atrophy.

    PubMed

    Cykowski, Matthew D; Coon, Elizabeth A; Powell, Suzanne Z; Jenkins, Sarah M; Benarroch, Eduardo E; Low, Phillip A; Schmeichel, Ann M; Parisi, Joseph E

    2015-08-01

    Multiple system atrophy is a sporadic alpha-synucleinopathy that typically affects patients in their sixth decade of life and beyond. The defining clinical features of the disease include progressive autonomic failure, parkinsonism, and cerebellar ataxia leading to significant disability. Pathologically, multiple system atrophy is characterized by glial cytoplasmic inclusions containing filamentous alpha-synuclein. Neuronal inclusions also have been reported but remain less well defined. This study aimed to further define the spectrum of neuronal pathology in 35 patients with multiple system atrophy (20 male, 15 female; mean age at death 64.7 years; median disease duration 6.5 years, range 2.2 to 15.6 years). The morphologic type, topography, and frequencies of neuronal inclusions, including globular cytoplasmic (Lewy body-like) neuronal inclusions, were determined across a wide spectrum of brain regions. A correlation matrix of pathologic severity also was calculated between distinct anatomic regions of involvement (striatum, substantia nigra, olivary and pontine nuclei, hippocampus, forebrain and thalamus, anterior cingulate and neocortex, and white matter of cerebrum, cerebellum, and corpus callosum). The major finding was the identification of widespread neuronal inclusions in the majority of patients, not only in typical disease-associated regions (striatum, substantia nigra), but also within anterior cingulate cortex, amygdala, entorhinal cortex, basal forebrain and hypothalamus. Neuronal inclusion pathology appeared to follow a hierarchy of region-specific susceptibility, independent of the clinical phenotype, and the severity of pathology was duration-dependent. Neuronal inclusions also were identified in regions not previously implicated in the disease, such as within cerebellar roof nuclei. Lewy body-like inclusions in multiple system atrophy followed the stepwise anatomic progression of Lewy body-spectrum disease inclusion pathology in 25.7% of patients

  11. Mean-field limit of systems with multiplicative noise.

    PubMed

    Muñoz, Miguel A; Colaiori, Francesca; Castellano, Claudio

    2005-11-01

    A detailed study of the mean-field solution of Langevin equations with multiplicative noise is presented. Three different regimes depending on noise intensity (weak, intermediate, and strong noise) are identified by performing a self-consistent calculation on a fully connected lattice. The most interesting, strong-noise, regime is shown to be intrinsically unstable with respect to the inclusion of fluctuations, as a Ginzburg criterion shows. On the other hand, the self-consistent approach is shown to be valid only in the thermodynamic limit, while for finite systems the critical behavior is found to be different. In this last case, the self-consistent field itself is broadly distributed rather than taking a well defined mean value; its fluctuations, described by an effective zero-dimensional multiplicative noise equation, govern the critical properties. These findings are obtained analytically for a fully connected graph, and verified numerically both on fully connected graphs and on random regular networks. The results presented here shed some doubt on what is the validity and meaning of a standard mean-field approach in systems with multiplicative noise in finite dimensions, where each site does not see an infinite number of neighbors, but a finite one. The implications of all this on the existence of a finite upper critical dimension for multiplicative noise and Kardar-Parisi-Zhang problems are briefly discussed.

  12. The MOS silicon gate technology and the first microprocessors

    NASA Astrophysics Data System (ADS)

    Faggin, F.

    2015-12-01

    Today we are so used to the enormous capabilities of microelectronics that it is hard to imagine what it might have been like in the early Sixties and Seventies when much of the technology we use today was being developed. This paper will first present a brief history of microelectronics and computers, taking us to the threshold of the inventions of the MOS silicon gate technology and the microprocessor. These two creations provided the basic technology that would allow only a few years later to merge microelectronics and computers into the first commercial monolithic computer. By the late Seventies, the first monolithic computer weighting less than one gram, occupying a volume of less than one cubic centimeter, dissipating less than one Watt, and selling for less than ten dollars, could perform more information processing than the UNIVAC I, the first commercial electronic computer introduced in 1951, made with 5200 vacuum tubes, dissipating 125kW, weighting 13 metric tons, occupying a room larger than 35m2, and selling for more than one million dollars per unit. The first-person story of the SGT and the early microprocessors will be told by the Italian-born physicist who led both projects.

  13. [Systemic amyloidosis associated with IgD-λ multiple myeloma].

    PubMed

    Nagamachi, Yasuhiro; Yamauchi, Naofumi; Muramatsu, Hirohito; Inomata, Hidetoshi; Nozawa, Eri; Koyama, Ryuzo; Ihara, Koji; Nishisato, Takuji; Yamada, Hideyuki; Yano, Tomohiro; Kikuchi, Shohei; Hirako, Tasuku; Kitaoka, Keisuke; Ono, Kaoru; Ihara, Hideyuki; Kato, Junji

    2011-12-01

    We describe here a case of systemic amyloidosis associated with IgD multiple myeloma. A 59-year-old man was admitted to our hospital in April 2009, because of macroglossia and swelling in both wrists and fingers. He had difficulty moving his limbs and was aware of peripheral neuropathy. Skin biopsy revealed extensive deposition of amyloidosis, which was positive by Congo red staining. Laboratory findings were as follows: serum electrophoresis revealed IgD λ monoclonal protein, and Bence-Jones protein was detected. Monoclonal IgD protein had a concentration of 727 mg/dl, and a bone marrow aspiration revealed 49.6% of plasma cells. These findings led to a diagnosis of IgD multiple myeloma with systemic amyloidosis. The patient was treated with MP (melphalan and methylprednisolone), high-dose dexamethasone and VAD therapy (vincristine, adriamycin and dexamethasone), but systemic amyloidosis progressed, and his general condition deteriorated. Coexistence of IgD multiple myeloma and systemic amyloidosis is rare, and accumulation of case reports is needed to gain a better understanding of this condition.

  14. Orbital Stability of Spacecraft Exploring Multiple Asteroid Systems

    NASA Astrophysics Data System (ADS)

    Burns, Keaton; Marchis, F.; Bellerose, J.

    2011-05-01

    Space missions to study the composition and formation histories of multiple asteroid systems require the identification of safe orbits for the observing spacecraft. To identify regions of orbital stability, we developed an n-body simulation and Monte Carlo scheme to test a large selection of orbits around the components of multiple asteroid systems. Our n-body program integrates the equations of motion of the spacecraft, asteroid system components, and the sun for 20 days, taking into account solar radiation pressure on the spacecraft and modeling asteroids as systems of rigid points when their shape model is known. We utilized a Monte Carlo scheme to test the stability of polar and retrograde orbits from uniformly distributed starting positions with normally distributed tangential velocities around each component. We present preliminary results of simulations testing hundreds of thousands of polar and retrograde orbits around the components of the 2001 SN263 near-earth triple asteroid system, and the (90) Antiope doublet and (45) Eugenia triple systems in the main-belt. These systems are potential targets for several space mission concepts, including: the Amor mission to visit and land on the components of 2001 SN263, Jones et al. (LPSC 42, #2695, 2011), the Diversity mission to explore several asteroid systems including (45) Eugenia and (90) Antiope, Marchis et al. (LPSC 42, #2062, 2011), and the ASTER mission to visit a NEA multiple asteroid, Sukhanov et al. (Cosmic Research 48-5, p. 443-450, 2010). Analysis of stable regions in position and velocity may assist in planning scientific orbits and instrumental specifications for such missions.

  15. FOREVER ALONE? TESTING SINGLE ECCENTRIC PLANETARY SYSTEMS FOR MULTIPLE COMPANIONS

    SciTech Connect

    Wittenmyer, Robert A.; Horner, Jonathan; Tinney, C. G.; Bailey, J.; Salter, G. S.; Wright, D.; Wang Songhu; Zhou Jilin; Butler, R. P.; Jones, H. R. A.; O'Toole, S. J.; Carter, B. D.

    2013-09-15

    Determining the orbital eccentricity of an extrasolar planet is critically important for understanding the system's dynamical environment and history. However, eccentricity is often poorly determined or entirely mischaracterized due to poor observational sampling, low signal-to-noise, and/or degeneracies with other planetary signals. Some systems previously thought to contain a single, moderate-eccentricity planet have been shown, after further monitoring, to host two planets on nearly circular orbits. We investigate published apparent single-planet systems to see if the available data can be better fit by two lower-eccentricity planets. We identify nine promising candidate systems and perform detailed dynamical tests to confirm the stability of the potential new multiple-planet systems. Finally, we compare the expected orbits of the single- and double-planet scenarios to better inform future observations of these interesting systems.

  16. Multiple exciton collection in a sensitized photovoltaic system.

    PubMed

    Sambur, Justin B; Novet, Thomas; Parkinson, B A

    2010-10-01

    Multiple exciton generation, the creation of two electron-hole pairs from one high-energy photon, is well established in bulk semiconductors, but assessments of the efficiency of this effect remain controversial in quantum-confined systems like semiconductor nanocrystals. We used a photoelectrochemical system composed of PbS nanocrystals chemically bound to TiO(2) single crystals to demonstrate the collection of photocurrents with quantum yields greater than one electron per photon. The strong electronic coupling and favorable energy level alignment between PbS nanocrystals and bulk TiO(2) facilitate extraction of multiple excitons more quickly than they recombine, as well as collection of hot electrons from higher quantum dot excited states. Our results have implications for increasing the efficiency of photovoltaic devices by avoiding losses resulting from the thermalization of photogenerated carriers.

  17. Multiple-Valued Immune Network with Apoptosis System

    NASA Astrophysics Data System (ADS)

    Yamaguchi, Takayuki; Tang, Zheng

    In this paper, we describe a new model of immune network based on biological immune response network. We propose an immunity like multiple-valued network with apoptosis mechanism. The model is based on the interaction between B cells and T cells and the biological apoptosis mechanism in human body. With the mechanism, a naturally immune system can be reproduced. The model is also applied to pattern recognition. It gets possible with a conventional model to restricting categories increase of memory patterns.

  18. Hot Flow Testing of Multiple Nozzle Exhaust Eductor Systems

    DTIC Science & Technology

    1979-09-01

    distribution unlimited. Hot Flow Testing of Multiple Nozzle Exhaust Eductor Systems by James Allan Hill Lieutenant, United States Navy B.A. Economics...8217M 3.. . . . . . . . A L). N30 - - 𔃺 0 N N N O. 3 ’ . . . .4 A% v 34 -- --- .L 4 44 Q 4 a 4 0 0 a 03 -r ’P 0 t .4. 0 0 0 0 0 0 a 3.q 4z -- . . . . 9

  19. System and process for pulsed multiple reaction monitoring

    DOEpatents

    Belov, Mikhail E

    2013-05-17

    A new pulsed multiple reaction monitoring process and system are disclosed that uses a pulsed ion injection mode for use in conjunction with triple-quadrupole instruments. The pulsed injection mode approach reduces background ion noise at the detector, increases amplitude of the ion signal, and includes a unity duty cycle that provides a significant sensitivity increase for reliable quantitation of proteins/peptides present at attomole levels in highly complex biological mixtures.

  20. Emergy evaluation of contrasting dairy systems at multiple levels.

    PubMed

    Vigne, Mathieu; Peyraud, Jean-Louis; Lecomte, Philippe; Corson, Michael S; Wilfart, Aurélie

    2013-11-15

    Emergy accounting (EmA) was applied to a range of dairy systems, from low-input smallholder systems in South Mali (SM), to intermediate-input systems in two regions of France, Poitou-Charentes (PC) and Bretagne (BR), to high-input systems on Reunion Island (RI). These systems were studied at three different levels: whole-farm (dairy system and cropping system), dairy-system (dairy herd and forage land), and herd (animals only). Dairy farms in SM used the lowest total emergy at all levels and was the highest user of renewable resources. Despite the low quality of resources consumed (crop residues and natural pasture), efficiency of their use was similar to that of industrialised inputs by intensive systems in RI, PC and BR. In addition, among the systems studied, SM dairy farms lay closest to environmental sustainability, contradicting the usual image of high environmental impact of cattle production in developing countries. EmA also revealed characteristics of the three intensive systems. Systems from RI and PC had lower resource transformation efficiency and higher environmental impacts than those from BR, due mainly to feeding strategies that differed due to differing socio-climatic constraints. Application of EmA at multiple levels revealed the importance of a multi-level analysis. While the whole-farm level assesses the overall contribution of the system to its environment, the dairy-system level is suitable for comparison of multi-product systems. In contrast, the herd level focuses on herd management and bypasses debates about definition of system boundaries by excluding land management. Combining all levels highlights the contribution of livestock to the global agricultural system and identifies inefficiencies and influences of system components on the environment.

  1. Multiple Object Based RFID System Using Security Level

    NASA Astrophysics Data System (ADS)

    Kim, Jiyeon; Jung, Jongjin; Ryu, Ukjae; Ko, Hoon; Joe, Susan; Lee, Yongjun; Kim, Boyeon; Chang, Yunseok; Lee, Kyoonha

    2007-12-01

    RFID systems are increasingly applied for operational convenience in wide range of industries and individual life. However, it is uneasy for a person to control many tags because common RFID systems have the restriction that a tag used to identify just a single object. In addition, RFID systems can make some serious problems in violation of privacy and security because of their radio frequency communication. In this paper, we propose a multiple object RFID tag which can keep multiple object identifiers for different applications in a same tag. The proposed tag allows simultaneous access for their pair applications. We also propose an authentication protocol for multiple object tag to prevent serious problems of security and privacy in RFID applications. Especially, we focus on efficiency of the authentication protocol by considering security levels of applications. In the proposed protocol, the applications go through different authentication procedures according to security level of the object identifier stored in the tag. We implemented the proposed RFID scheme and made experimental results about efficiency and stability for the scheme.

  2. Development and evaluation of a microprocessor-based ergonomic dosimeter for evaluating carpentry tasks.

    PubMed

    Bhattacharya, A; Warren, J; Teuschler, J; Dimov, M; Medvedovic, M; Lemasters, G

    1999-12-01

    This portable and self-contained lightweight microprocessor based Ergonomic Dosimeter is designed to collect continuously postural angles of the torso and the upper arm in the sagittal plane and the number of kneeling activities. Up to 4 h of task performance data can be stored in a non-volatile memory of the dosimeter, which can then be downloaded to a lap-top computer. The portable dosimeter was tested for test-retest reliability, compared with posture data obtained with a computer-based video analysis system and evaluated at a carpenter's apprentices school and at a construction site. The dosimeter was shown to be suitable for collecting posture and kneeling data for a prolonged period at construction sites.

  3. Multi-crop area estimation and mapping on a microprocessor/mainframe network

    NASA Technical Reports Server (NTRS)

    Sheffner, E.

    1985-01-01

    The data processing system is outlined for a 1985 test aimed at determining the performance characteristics of area estimation and mapping procedures connected with the California Cooperative Remote Sensing Project. The project is a joint effort of the USDA Statistical Reporting Service-Remote Sensing Branch, the California Department of Water Resources, NASA-Ames Research Center, and the University of California Remote Sensing Research Program. One objective of the program was to study performance when data processing is done on a microprocessor/mainframe network under operational conditions. The 1985 test covered the hardware, software, and network specifications and the integration of these three components. Plans for the year - including planned completion of PEDITOR software, testing of software on MIDAS, and accomplishment of data processing on the MIDAS-VAX-CRAY network - are discussed briefly.

  4. A microprocessor-based digital feeder monitor with high-impedance fault detection

    SciTech Connect

    Patterson, R.; Tyska, W.; Russell, B.D.

    1994-12-31

    The high impedance fault detection technology developed at Texas A&M University after more than a decade of research, funded in large part by the Electric Power Research Institute, has been incorporated into a comprehensive monitoring device for overhead distribution feeders. This digital feeder monitor (DFM) uses a high waveform sampling rate for the ac current and voltage inputs in conjunction with a high-performance reduced instruction set (RISC) microprocessor to obtain the frequency response required for arcing fault detection and power quality measurements. Expert system techniques are employed to assure security while maintaining dependability. The DFM is intended to be applied at a distribution substation to monitor one feeder. The DFM is packaged in a non-drawout case which fits the panel cutout for a GE IAC overcurrent relay to facilitate retrofits at the majority of sites were electromechanical overcurrent relays already exist.

  5. Design of a microprocessor based novel braking of three phase induction motor

    SciTech Connect

    Sinha, N.; Laskar, S.H.; Goyal, K.; Nair, P.B.; Sharma, M.K.

    1995-12-31

    This paper describes the development of an efficient braking system suitable for three phase induction motor drives specially driving loads of non-overhauling type. The method incorporates a combination of three braking methods in four states according to the speed range at which the respective methods are most effective, with the result of a smooth and efficient braking. First capacitor self-excitation is applied in stages followed by magnetic braking by double short circuiting and dc injection. Theoretical and experimental results for determining different parameters useful for designing the braking scheme are provided. Lastly microprocessor has been used for proper incorporation of different braking schemes. Dual switching scheme has improved the reliability of the scheme.

  6. Performance analysis of commercial multiple-input-multiple-output access point in distributed antenna system.

    PubMed

    Fan, Yuting; Aighobahi, Anthony E; Gomes, Nathan J; Xu, Kun; Li, Jianqiang

    2015-03-23

    In this paper, we experimentally investigate the throughput of IEEE 802.11n 2x2 multiple-input-multiple-output (MIMO) signals in a radio-over-fiber-based distributed antenna system (DAS) with different fiber lengths and power imbalance. Both a MIMO-supported access point (AP) and a spatial-diversity-supported AP were separately employed in the experiments. Throughput measurements were carried out with wireless users at different locations in a typical office environment. For the different fiber length effect, the results indicate that MIMO signals can maintain high throughput when the fiber length difference between the two remote antenna units (RAUs) is under 100 m and falls quickly when the length difference is greater. For the spatial diversity signals, high throughput can be maintained even when the difference is 150 m. On the other hand, the separation of the MIMO antennas allows additional freedom in placing the antennas in strategic locations for overall improved system performance, although it may also lead to received power imbalance problems. The results show that the throughput performance drops in specific positions when the received power imbalance is above around 13 dB. Hence, there is a trade-off between the extent of the wireless coverage for moderate bit-rates and the area over which peak bit-rates can be achieved.

  7. [The Multiple Sclerosis Documentation System MSDS. Discussion of a documentation standard for multiple sclerosis].

    PubMed

    Pette, M; Eulitz, M

    2002-02-01

    The MSDS (multiple sclerosis documentation system) has been developed at the Department of Neurology, Technical University of Dresden, Germany, during the last 4 years. The first version of this database application has been in use since October 2000. The MSDS manages information on MS patients, their treating physicians, patient history (symptoms, other diseases, biographical history, family history, habits, medication), clinical signs, results of laboratory examinations (blood chemistry, autoantibodies, borrelia serology, evoked potentials, cranial and spinal cord magnetic resonance imaging), clinical scores relevant for MS, and biosamples. In principle, MSDS allows online data input and semiautomatically generates reports to all general practitioners and neurologists treating the respective patient. Patient information sheets and internal treatment guidelines are part of the system. During a 3-month evaluation, the first version of MSDS was tested at eight university multiple sclerosis ambulatory care units and one general neurology hospital. The overall judgement was favorable. Suggestions for changes and improvements, as well as practical experiences, were considered when developing MSDS 2.0, which will be available by the end of 2001.

  8. Stress and multiple memory systems: from 'thinking' to 'doing'.

    PubMed

    Schwabe, Lars; Wolf, Oliver T

    2013-02-01

    Although it has been known for decades that stress influences memory performance, it was only recently shown that stress may alter the contribution of multiple, anatomically and functionally distinct memory systems to behavior. Here, we review recent animal and human studies demonstrating that stress promotes a shift from flexible 'cognitive' to rather rigid 'habit' memory systems and discuss, based on recent neuroimaging data in humans, the underlying brain mechanisms. We argue that, despite being generally adaptive, this stress-induced shift towards 'habit' memory may, in vulnerable individuals, be a risk factor for psychopathology.

  9. Wireline system for multiple direct push tool usage

    DOEpatents

    Bratton, Wesley L.; Farrington, Stephen P.; Shinn, II, James D.; Nolet, Darren C.

    2003-11-11

    A tool latching and retrieval system allows the deployment and retrieval of a variety of direct push subsurface characterization tools through an embedded rod string during a single penetration without requiring withdrawal of the string from the ground. This enables the in situ interchange of different tools, as well as the rapid retrieval of soil core samples from multiple depths during a single direct push penetration. The system includes specialized rods that make up the rod string, a tool housing which is integral to the rod string, a lock assembly, and several tools which mate to the lock assembly.

  10. Multiple-lamp illumination system for projection displays

    NASA Astrophysics Data System (ADS)

    Vanderwerf, Dennis F.

    1996-03-01

    This paper describes a diascopic projection system that efficiently combines and integrates the output from multiple light sources. The images of these light sources are superposed at a common focus in the projection lens, resulting in a projected screen brightness considerably greater than that produced by a single lamp of equivalent wattage. The illumination system consists of a series of collimating and converging plastic Fresnel lenses, and a linear beam- integrating micro-prismatic element. Glass anamorphic condenser optics are also used. The optics can be cascaded, and the design requirements of a four-lamp system is described. The experimental results from a laboratory developed overhead projection system using dual tungsten-halogen lamps is discussed.

  11. System and method for inventorying multiple remote objects

    DOEpatents

    Carrender, Curtis L.; Gilbert, Ronald W.

    2007-10-23

    A system and method of inventorying multiple objects utilizing a multi-level or a chained radio frequency identification system. The system includes a master tag and a plurality of upper level tags and lower level tags associated with respective objects. The upper and lower level tags communicate with each other and the master tag so that reading of the master tag reveals the presence and absence of upper and lower level tags. In the chained RF system, the upper and lower level tags communicate locally with each other in a manner so that more remote tags that are out of range of some of the upper and lower level tags have their information relayed through adjacent tags to the master tag and thence to a controller.

  12. System and method for inventorying multiple remote objects

    DOEpatents

    Carrender, Curtis L.; Gilbert, Ronald W.

    2009-12-29

    A system and method of inventorying multiple objects utilizing a multi-level or a chained radio frequency identification system. The system includes a master tag and a plurality of upper level tags and lower level tags associated with respective objects. The upper and lower level tags communicate with each other and the master tag so that reading of the master tag reveals the presence and absence of upper and lower level tags. In the chained RF system, the upper and lower level tags communicate locally with each other in a manner so that more remote tags that are out of range of some of the upper and lower level tags have their information relayed through adjacent tags to the master tag and thence to a controller.

  13. Simultaneous real-time monitoring of multiple cortical systems

    NASA Astrophysics Data System (ADS)

    Gupta, Disha; Hill, N. Jeremy; Brunner, Peter; Gunduz, Aysegul; Ritaccio, Anthony L.; Schalk, Gerwin

    2014-10-01

    Objective. Real-time monitoring of the brain is potentially valuable for performance monitoring, communication, training or rehabilitation. In natural situations, the brain performs a complex mix of various sensory, motor or cognitive functions. Thus, real-time brain monitoring would be most valuable if (a) it could decode information from multiple brain systems simultaneously, and (b) this decoding of each brain system were robust to variations in the activity of other (unrelated) brain systems. Previous studies showed that it is possible to decode some information from different brain systems in retrospect and/or in isolation. In our study, we set out to determine whether it is possible to simultaneously decode important information about a user from different brain systems in real time, and to evaluate the impact of concurrent activity in different brain systems on decoding performance. Approach. We study these questions using electrocorticographic signals recorded in humans. We first document procedures for generating stable decoding models given little training data, and then report their use for offline and for real-time decoding from 12 subjects (six for offline parameter optimization, six for online experimentation). The subjects engage in tasks that involve movement intention, movement execution and auditory functions, separately, and then simultaneously. Main results. Our real-time results demonstrate that our system can identify intention and movement periods in single trials with an accuracy of 80.4% and 86.8%, respectively (where 50% would be expected by chance). Simultaneously, the decoding of the power envelope of an auditory stimulus resulted in an average correlation coefficient of 0.37 between the actual and decoded power envelopes. These decoders were trained separately and executed simultaneously in real time. Significance. This study yielded the first demonstration that it is possible to decode simultaneously the functional activity of multiple

  14. Multiple fuel supply system for an internal combustion engine

    DOEpatents

    Crothers, William T.

    1977-01-01

    A multiple fuel supply or an internal combustion engine wherein phase separation of components is deliberately induced. The resulting separation permits the use of a single fuel tank to supply components of either or both phases to the engine. Specifically, phase separation of a gasoline/methanol blend is induced by the addition of a minor amount of water sufficient to guarantee separation into an upper gasoline phase and a lower methanol/water phase. A single fuel tank holds the two-phase liquid with separate fuel pickups and separate level indicators for each phase. Either gasoline or methanol, or both, can be supplied to the engine as required by predetermined parameters. A fuel supply system for a phase-separated multiple fuel supply contained in a single fuel tank is described.

  15. Propagation error minimization method for multiple structural displacement monitoring system

    NASA Astrophysics Data System (ADS)

    Jeon, Haemin; Shin, Jae-Uk; Myung, Hyun

    2013-04-01

    In the previous study, a visually servoed paired structured light system (ViSP) which is composed of two sides facing each other, each with one or two lasers, a 2-DOF manipulator, a camera, and a screen has been proposed. The lasers project their parallel beams to the screen on the opposite side and 6-DOF relative displacement between two sides is estimated by calculating positions of the projected laser beams and rotation angles of the manipulators. To apply the system to massive civil structures such as long-span bridges or high-rise buildings, the whole area should be divided into multiple partitions and each ViSP module is placed in each partition in a cascaded manner. In other words, the movement of the entire structure can be monitored by multiplying the estimated displacements from multiple ViSP modules. In the multiplication, however, there is a major problem that the displacement estimation error is propagated throughout the multiple modules. To solve the problem, propagation error minimization method (PEMM) which uses Newton-Raphson formulation inspired by the error back-propagation algorithm is proposed. In this method, a propagation error at the last module is calculated and then the estimated displacement from ViSP at each partition is updated in reverse order by using the proposed PEMM that minimizes the propagation error. To verify the performance of the proposed method, various simulations and experimental tests have been performed. The results show that the propagation error is significantly reduced after applying PEMM.

  16. Motion coordination and performance analysis of multiple vehicle systems

    NASA Astrophysics Data System (ADS)

    Sharma, Vikrant

    In this dissertation, issues related to multiple vehicle systems are studied. First, the issue of vehicular congestion is addressed and its effect on the performance of some systems studied. Motion coordination algorithms for some systems of interest are also developed. The issue of vehicular congestion is addressed by characterizing the effect of increasing the number of vehicles, in a bounded region, on the speed of the vehicles. A multiple vehicle routing problem is considered where vehicles are required to stay velocity-dependent distance away from each other to avoid physical collisions. Optimal solutions to the minimum time routing are characterized and are found to increase with the square root of the number of vehicles in the environment, for different distributions of the sources and destinations of the vehicles. The second issue addressed is that of the effect of vehicular congestion on the delay associated with data delivery in wireless networks where vehicles are used to transport data to increase the wireless capacity of the network. Tight bounds on the associated delay are derived. The next problem addressed is that of covering an arbitrary path-connected two dimensional region, using multiple unmanned aerial vehicles, in minimum time. A constant-factor optimal algorithm is presented for any given initial positions of the vehicles inside the environment. The last problem addressed is that of the deployment of an environment monitoring network of mobile sensors to improve the network lifetime and sensing quality. A distributed algorithm is presented that improves the system's performance starting from an initial deployment.

  17. MACSIMS : multiple alignment of complete sequences information management system

    PubMed Central

    Thompson, Julie D; Muller, Arnaud; Waterhouse, Andrew; Procter, Jim; Barton, Geoffrey J; Plewniak, Frédéric; Poch, Olivier

    2006-01-01

    Background In the post-genomic era, systems-level studies are being performed that seek to explain complex biological systems by integrating diverse resources from fields such as genomics, proteomics or transcriptomics. New information management systems are now needed for the collection, validation and analysis of the vast amount of heterogeneous data available. Multiple alignments of complete sequences provide an ideal environment for the integration of this information in the context of the protein family. Results MACSIMS is a multiple alignment-based information management program that combines the advantages of both knowledge-based and ab initio sequence analysis methods. Structural and functional information is retrieved automatically from the public databases. In the multiple alignment, homologous regions are identified and the retrieved data is evaluated and propagated from known to unknown sequences with these reliable regions. In a large-scale evaluation, the specificity of the propagated sequence features is estimated to be >99%, i.e. very few false positive predictions are made. MACSIMS is then used to characterise mutations in a test set of 100 proteins that are known to be involved in human genetic diseases. The number of sequence features associated with these proteins was increased by 60%, compared to the features available in the public databases. An XML format output file allows automatic parsing of the MACSIM results, while a graphical display using the JalView program allows manual analysis. Conclusion MACSIMS is a new information management system that incorporates detailed analyses of protein families at the structural, functional and evolutionary levels. MACSIMS thus provides a unique environment that facilitates knowledge extraction and the presentation of the most pertinent information to the biologist. A web server and the source code are available at . PMID:16792820

  18. Biosorption of gold from computer microprocessor leachate solutions using chitin.

    PubMed

    Côrtes, Letícia N; Tanabe, Eduardo H; Bertuol, Daniel A; Dotto, Guilherme L

    2015-11-01

    The biosorption of gold from discarded computer microprocessor (DCM) leachate solutions was studied using chitin as a biosorbent. The DCM components were leached with thiourea solutions, and two procedures were tested for recovery of gold from the leachates: (1) biosorption and (2) precipitation followed by biosorption. For each procedure, the biosorption was evaluated considering kinetic, equilibrium, and thermodynamic aspects. The general order model was able to represent the kinetic behavior, and the equilibrium was well represented by the BET model. The maximum biosorption capacities were around 35 mg g(-1) for both procedures. The biosorption of gold on chitin was a spontaneous, favorable, and exothermic process. It was found that precipitation followed by biosorption resulted in the best gold recovery, because other species were removed from the leachate solution in the precipitation step. This method enabled about 80% of the gold to be recovered, using 20 g L(-1) of chitin at 298 K for 4 h.

  19. Transient fault behavior in a microprocessor: A case study

    NASA Technical Reports Server (NTRS)

    Duba, Patrick

    1989-01-01

    An experimental analysis is described which studies the susceptibility of a microprocessor based jet engine controller to upsets caused by current and voltage transients. A design automation environment which allows the run time injection of transients and the tracing from their impact device to the pin level is described. The resulting error data are categorized by the charge levels of the injected transients by location and by their potential to cause logic upsets, latched errors, and pin errors. The results show a 3 picoCouloumb threshold, below which the transients have little impact. An Arithmetic and Logic Unit transient is most likely to result in logic upsets and pin errors (i.e., impact the external environment). The transients in the countdown unit are potentially serious since they can result in latched errors, thus causing latent faults. Suggestions to protect the processor against these errors, by incorporating internal error detection and transient suppression techniques, are also made.

  20. Satisfying STEM Education Using the Arduino Microprocessor in C Programming

    NASA Astrophysics Data System (ADS)

    Hoffer, Brandyn M.

    There exists a need to promote better Science Technology Engineering and Math (STEM) education at the high school level. To satisfy this need a series of hands-on laboratory assignments were created to be accompanied by 2 educational trainers that contain various electronic components. This project provides an interdisciplinary, hands-on approach to teaching C programming that meets several standards defined by the Tennessee Board of Education. Together the trainers and lab assignments also introduce key concepts in math and science while allowing students hands-on experience with various electronic components. This will allow students to mimic real world applications of using the C programming language while exposing them to technology not currently introduced in many high school classrooms. The developed project is targeted at high school students performing at or above the junior level and uses the Arduino Mega open-source Microprocessor and software as the primary control unit.

  1. Charging system with galvanic isolation and multiple operating modes

    SciTech Connect

    Kajouke, Lateef A.; Perisic, Milun; Ransom, Ray M.

    2013-01-08

    Systems and methods are provided for operating a charging system with galvanic isolation adapted for multiple operating modes. A vehicle charging system comprises a DC interface, an AC interface, a first conversion module coupled to the DC interface, and a second conversion module coupled to the AC interface. An isolation module is coupled between the first conversion module and the second conversion module. The isolation module comprises a transformer and a switching element coupled between the transformer and the second conversion module. The transformer and the switching element are cooperatively configured for a plurality of operating modes, wherein each operating mode of the plurality of operating modes corresponds to a respective turns ratio of the transformer.

  2. Multiple-Point Mass Flux Measurement System Using Rayleigh Scattering

    NASA Technical Reports Server (NTRS)

    Mielke, Amy F.; Elam, Kristie A.; Clem, Michelle M.

    2009-01-01

    A multiple-point Rayleigh scattering diagnostic is being developed to provide mass flux measurements in gas flows. Spectroscopic Rayleigh scattering is an established flow diagnostic that has the ability to provide simultaneous density, temperature, and velocity measurements. Rayleigh scattered light from a focused 18 Watt continuous-wave laser beam is directly imaged through a solid Fabry-Perot etalon onto a CCD detector which permits spectral analysis of the light. The spatial resolution of the measurements is governed by the locations of interference fringes, which can be changed by altering the etalon characteristics. A prototype system has been used to acquire data in a Mach 0.56 flow to demonstrate feasibility of using this system to provide mass flux measurements. Estimates of measurement uncertainty and recommendations for system improvements are presented

  3. Comparing fault susceptibility of multiple ISAs and operating systems

    NASA Astrophysics Data System (ADS)

    Chyłek, Sławomir

    2015-09-01

    This paper presents a research that aims to compare effects of faults on different configurations of computer systems. The study covers comparison of susceptibility to faults of x86, AMD64, ARM, PowerPC, MIPS architectures and Linux, FreeBSD, Minix operating systems. An emulation based software implemented fault injection technique was used to perform experiments. The problem of choosing an adequate number of tests in experiments is followed by report with collected results where multiple aspects of test runs were analyzed: providing correct computation result, availability of the system under test and error messages. The research allows to determine characteristics of susceptibility to faults of each platform and is a first step towards designing new fault tolerance solutions and assessing their effectiveness.

  4. Thermodynamics of quantum systems with multiple conserved quantities

    PubMed Central

    Guryanova, Yelena; Popescu, Sandu; Short, Anthony J.; Silva, Ralph; Skrzypczyk, Paul

    2016-01-01

    Recently, there has been much progress in understanding the thermodynamics of quantum systems, even for small individual systems. Most of this work has focused on the standard case where energy is the only conserved quantity. Here we consider a generalization of this work to deal with multiple conserved quantities. Each conserved quantity, which, importantly, need not commute with the rest, can be extracted and stored in its own battery. Unlike the standard case, in which the amount of extractable energy is constrained, here there is no limit on how much of any individual conserved quantity can be extracted. However, other conserved quantities must be supplied, and the second law constrains the combination of extractable quantities and the trade-offs between them. We present explicit protocols that allow us to perform arbitrarily good trade-offs and extract arbitrarily good combinations of conserved quantities from individual quantum systems. PMID:27384384

  5. Novel Public Key Encryption Technique Based on Multiple Chaotic Systems

    NASA Astrophysics Data System (ADS)

    Bose, Ranjan

    2005-08-01

    Public key encryption was first introduced by Diffie and Hellman in 1976. Since then, the Diffie-Hellman key exchange protocol has been used in developing public key systems such as Rivest-Shamir-Adleman and elliptic curve cryptography. Chaotic functions, so far, have been used for symmetric cryptography only. In this Letter we propose, for the first time, a methodology to use multiple chaotic systems and a set of linear functions for key exchange over an insecure channel. To the best of our knowledge, this is the first Letter that reports the use of chaotic systems for public key cryptography. We have shown that the security of the proposed algorithm grows as (NP)m, where N, P, and m are large numbers that can be chosen as the parameters of the cryptosystem.

  6. Novel public key encryption technique based on multiple chaotic systems.

    PubMed

    Bose, Ranjan

    2005-08-26

    Public key encryption was first introduced by Diffie and Hellman in 1976. Since then, the Diffie-Hellman key exchange protocol has been used in developing public key systems such as Rivest-Shamir-Adleman and elliptic curve cryptography. Chaotic functions, so far, have been used for symmetric cryptography only. In this Letter we propose, for the first time, a methodology to use multiple chaotic systems and a set of linear functions for key exchange over an insecure channel. To the best of our knowledge, this is the first Letter that reports the use of chaotic systems for public key cryptography. We have shown that the security of the proposed algorithm grows as (NP)(m), where N, P, and m are large numbers that can be chosen as the parameters of the cryptosystem.

  7. The role of information system in multiple sclerosis management.

    PubMed

    Ajami, Sima; Ahmadi, Golchehreh; Etemadifar, Masoud

    2014-12-01

    Multiple sclerosis (MS) is a chronic disease of central nervous system. The multiple sclerosis information system (MSIS), such as other information system (IS), depends on identification, collection and processing of data for producing useful information. Lack of the integrated IS for collecting standard data causes undesirable effects on exchanging, comparing, and managing. The aim of this study was to recognize the role of the IS in the MS management and determine the advantages and barriers in implementing of the MSIS. The present study was a nonsystematized review that was done in order to recognize the role of the IS in the MS management. In this study, electronic scientific resources such as scientific magazines and books and published topics at conferences were used. We used key words (IS, chronic disease management, and multiple sclerosis), their combination or their synonyms in title, key words, abstracts, and text of English articles and published reports from 1980 until 2013, and by using search engines such as Google, Google Scholar and scientific databases and electronic issues such as iPubMed, sufficiently important difference, Scopus, Medlib, and Magiran for gathering information. More than 200 articles and reports were collected and assessed and 139 of them. Findings showed that the MSIS can reduce of disease expenses through continuously collecting correct, accurate, sufficient, and timely patients and disease nature information; recoding; editing; processing; exchanging, and distributing among different health care centers. Although the MSIS has many advantages; but, we cannot ignore cultural, economic, technical, organizational, and managerial barriers. Therefore, it is necessary to do studies for preventing, reducing, and controlling them. One of the ways is to recognize the advantages of the MSIS and usage information technology in optimizing disease management.

  8. Multiple brain atlas database and atlas-based neuroimaging system.

    PubMed

    Nowinski, W L; Fang, A; Nguyen, B T; Raphel, J K; Jagannathan, L; Raghavan, R; Bryan, R N; Miller, G A

    1997-01-01

    For the purpose of developing multiple, complementary, fully labeled electronic brain atlases and an atlas-based neuroimaging system for analysis, quantification, and real-time manipulation of cerebral structures in two and three dimensions, we have digitized, enhanced, segmented, and labeled the following print brain atlases: Co-Planar Stereotaxic Atlas of the Human Brain by Talairach and Tournoux, Atlas for Stereotaxy of the Human Brain by Schaltenbrand and Wahren, Referentially Oriented Cerebral MRI Anatomy by Talairach and Tournoux, and Atlas of the Cerebral Sulci by Ono, Kubik, and Abernathey. Three-dimensional extensions of these atlases have been developed as well. All two- and three-dimensional atlases are mutually preregistered and may be interactively registered with an actual patient's data. An atlas-based neuroimaging system has been developed that provides support for reformatting, registration, visualization, navigation, image processing, and quantification of clinical data. The anatomical index contains about 1,000 structures and over 400 sulcal patterns. Several new applications of the brain atlas database also have been developed, supported by various technologies such as virtual reality, the Internet, and electronic publishing. Fusion of information from multiple atlases assists the user in comprehensively understanding brain structures and identifying and quantifying anatomical regions in clinical data. The multiple brain atlas database and atlas-based neuroimaging system have substantial potential impact in stereotactic neurosurgery and radiotherapy by assisting in visualization and real-time manipulation in three dimensions of anatomical structures, in quantitative neuroradiology by allowing interactive analysis of clinical data, in three-dimensional neuroeducation, and in brain function studies.

  9. The role of information system in multiple sclerosis management

    PubMed Central

    Ajami, Sima; Ahmadi, Golchehreh; Etemadifar, Masoud

    2014-01-01

    Multiple sclerosis (MS) is a chronic disease of central nervous system. The multiple sclerosis information system (MSIS), such as other information system (IS), depends on identification, collection and processing of data for producing useful information. Lack of the integrated IS for collecting standard data causes undesirable effects on exchanging, comparing, and managing. The aim of this study was to recognize the role of the IS in the MS management and determine the advantages and barriers in implementing of the MSIS. The present study was a nonsystematized review that was done in order to recognize the role of the IS in the MS management. In this study, electronic scientific resources such as scientific magazines and books and published topics at conferences were used. We used key words (IS, chronic disease management, and multiple sclerosis), their combination or their synonyms in title, key words, abstracts, and text of English articles and published reports from 1980 until 2013, and by using search engines such as Google, Google Scholar and scientific databases and electronic issues such as iPubMed, sufficiently important difference, Scopus, Medlib, and Magiran for gathering information. More than 200 articles and reports were collected and assessed and 139 of them. Findings showed that the MSIS can reduce of disease expenses through continuously collecting correct, accurate, sufficient, and timely patients and disease nature information; recoding; editing; processing; exchanging, and distributing among different health care centers. Although the MSIS has many advantages; but, we cannot ignore cultural, economic, technical, organizational, and managerial barriers. Therefore, it is necessary to do studies for preventing, reducing, and controlling them. One of the ways is to recognize the advantages of the MSIS and usage information technology in optimizing disease management. PMID:25709660

  10. Lung function measurement with multiple-breath-helium washout system.

    PubMed

    Wang, J-Y; Suddards, M E; Mellor, C J; Owers-Bradley, J R

    2013-04-01

    Multiple-breath-washout (MBW) measurements are regarded as a sensitive technique which can reflect the ventilation inhomogeneity of respiratory airways. Typically nitrogen is used as the tracer gas and is washed out by pure oxygen in multiple-breath-nitrogen washout (MBNW) tests. In this study, instead of using nitrogen, (4)He is used as the tracer gas with smaller gas density which may be able to reach deeper into our lungs in a given time and the helium washout results may be more sensitive to the ventilation inhomogeneity in small airways. A multiple-breath-helium-washout (MBHW) system developed for the lung function study is also presented. Quartz tuning forks with a resonance frequency of 32,768Hz have been used for detecting the change of the respiratory gas density. The resonance frequency of the quartz tuning fork decreases linearly with increasing density of the surrounding gas. Knowing the CO2 concentration from the infrared carbon dioxide detector, the helium concentration can be determined. Results from 14 volunteers (3 mild asthmatics, 4 tobacco smokers, 1 with asthma history, 1 with COPD history, 5 normal) have shown that mild asthmatics have higher ventilation inhomogeneity in either conducting or acinar airways (or both). A feature has been found in washout curve of single breaths from 4 tobacco smokers with different length of smoking history which may indicate the early stage of respiratory ventilation inhomogeneity in acinar airways.

  11. Report on the formal specification and partial verification of the VIPER microprocessor

    NASA Technical Reports Server (NTRS)

    Brock, Bishop; Hunt, Warren A., Jr.

    1991-01-01

    The formal specification and partial verification of the VIPER microprocessor is reviewed. The VIPER microprocessor was designed by RSRE, Malvern, England, for safety critical computing applications (e.g., aircraft, reactor control, medical instruments, armaments). The VIPER was carefully specified and partially verified in an attempt to provide a microprocessor with completely predictable operating characteristics. The specification of VIPER is divided into several levels of abstraction, from a gate-level description up to an instruction execution model. Although the consistency between certain levels was demonstrated with mechanically-assisted mathematical proof, the formal verification of VIPER was never completed.

  12. Involvement of medullary serotonergic groups in multiple system atrophy.

    PubMed

    Benarroch, Eduardo E; Schmeichel, Ann M; Low, Phillip A; Parisi, Joseph E

    2004-03-01

    We sought to determine whether medullary serotonergic neurons were affected in multiple system atrophy (MSA). Immunostaining for tryptophan hydroxylase was performed on serial 50 microm sections of the medulla of brains obtained at autopsy from six control subjects, eight subjects with clinical diagnosis of MSA, and four with Parkinson's disease. There was a severe depletion of serotonergic neurons in the nucleus raphe magnus, raphe obscurus, raphe pallidus, and ventrolateral medulla in MSA. Depletion of serotonergic neurons may contribute to impaired control of sympathetic outflow and other abnormalities in MSA.

  13. Failure management of multiple gimbal inertial systems for space shuttle

    NASA Technical Reports Server (NTRS)

    Dove, D. W.; Mckern, R. A.

    1973-01-01

    A failure detection and isolation technique for use with four gimbaled inertial measurement units (IMU) is presented. By using simulated boost and entry shuttle trajectories with specific gimbaled IMU models, failure detection thresholds are developed based on red-line life dependent requirements and warning thresholds within the red-line thresholds based on expected worst case IMU performance. Using these trajectories, established trajectory threshold, and multiple IMU models, various failure detection and isolation techniques are evaluated for application in both powered and unpowered flight phases. The adequacy of the systems for both attitude and velocity detection methods is evaluated and recommendations for space shuttle applications are made.

  14. Multiprocessor system with multiple concurrent modes of execution

    SciTech Connect

    Ahn, Daniel; Ceze, Luis H.; Chen, Dong Chen; Gara, Alan; Heidelberger, Philip; Ohmacht, Martin

    2016-11-22

    A multiprocessor system supports multiple concurrent modes of speculative execution. Speculation identification numbers (IDs) are allocated to speculative threads from a pool of available numbers. The pool is divided into domains, with each domain being assigned to a mode of speculation. Modes of speculation include TM, TLS, and rollback. Allocation of the IDs is carried out with respect to a central state table and using hardware pointers. The IDs are used for writing different versions of speculative results in different ways of a set in a cache memory.

  15. Flocking of multi-agent systems with multiple groups

    NASA Astrophysics Data System (ADS)

    Jing, Gangshan; Zheng, Yuanshi; Wang, Long

    2014-12-01

    In this paper, we consider the flocking problem of multi-agent systems with multiple groups. First, some algorithms using local information are designed to divide the agents into any pre-assigned number of groups in fixed and switching heterogeneous networks, respectively. Based on algebraic graph theory and Barbalat's lemma, convergence criteria are established to ensure velocity alignment and cohesion of each subgroup as well as collision avoidance between any agents in the whole group. Second, an algorithm for homogeneous networks is studied. Simulation examples are finally presented to verify the effectiveness of our theoretical results.

  16. Multiprocessor system with multiple concurrent modes of execution

    DOEpatents

    Ahn, Daniel; Ceze, Luis H; Chen, Dong; Gara, Alan; Heidelberger, Philip; Ohmacht, Martin

    2013-12-31

    A multiprocessor system supports multiple concurrent modes of speculative execution. Speculation identification numbers (IDs) are allocated to speculative threads from a pool of available numbers. The pool is divided into domains, with each domain being assigned to a mode of speculation. Modes of speculation include TM, TLS, and rollback. Allocation of the IDs is carried out with respect to a central state table and using hardware pointers. The IDs are used for writing different versions of speculative results in different ways of a set in a cache memory.

  17. The multiple parameter hemodynamic imaging system based on ARM

    NASA Astrophysics Data System (ADS)

    Tang, Xuejun; He, Heng; Jiang, Chao; Li, Pengcheng; Luo, Qingming

    2008-12-01

    Optical imaging with high resolution is significant to reveal the functional activities of brain and the mechanism of disease, and has grown into a diverse field. The high-resolution multi-parameters optical imaging system which combines the laser speckle contrast imaging method and optical intrinsic signal imaging method can obtain more hemodynamic information in cortex simultaneously. However, most of current optical imaging systems use He-Ne laser and mercury xenon arc lamp as the light source. Meanwhile, the control unit of the system which includes a personal computer, is not portable. In this paper, we develop a multiple parameters hemodynamic imaging system based on ARM. To make the system more compact, three wavelengths light-emitting diode and laser diode as imaging illuminants were adopted. In addition, the real-time embedded operation system (μC/OS-II) and embedded Graphic User Interface (μC/GUI) were introduced. Animal experimental results also show that changes in oxyhemoglobin, deoxyhemoglobin, total hemoglobin concentration and cerebral blood flow during Cortical Spreading Depression can be simultaneously accessed using this optical imaging system based on embedded ARM.

  18. Coded multiple chirp spread spectrum system and overlay service

    NASA Technical Reports Server (NTRS)

    Kim, Junghwan; Pratt, Timothy; Ha, Tri T.

    1988-01-01

    An asynchronous spread-spectrum system called coded multiple chirp is proposed, and the possible spread-spectrum overlay over an analog FM-TV signal is investigated by computer simulation. Multiple single-sloped up and down chirps are encoded by a pseudonoise code and decoded by dechirpers (pulse-compression filters) followed by a digital code correlator. The performance of the proposed system, expressed in terms of in probability of bit error and code miss probability, is similar to that of FSK (frequency shift keying) using codewords if sufficient compression gain is used. When chirp is used to overlay an FM-TV channel, two chirp signals with data rate up to 25 kb/s could be overlaid in a 36-MHz satellite transponder without significant mutual interference. Performance estimates for a VSAT (very small aperture terminal) earth station operating at C-band show that a 2.4-m antenna and 300-mW transmitter could send a 2.4-kb/s signal to a large central earth station over an occupied channel.

  19. Metal halogen battery system with multiple outlet nozzle for hydrate

    DOEpatents

    Bjorkman, Jr., Harry K.

    1983-06-21

    A metal halogen battery system, including at least one cell having a positive electrode and a negative electrode contacted by aqueous electrolyte containing the material of said metal and halogen, store means whereby halogen hydrate is formed and stored as part of an aqueous material, means for circulating electrolyte through the cell and to the store means, and conduit means for transmitting halogen gas formed in the cell to a hydrate former whereby the hydrate is formed in association with the store means, said store means being constructed in the form of a container which includes a filter means, said filter means being inoperative to separate the hydrate formed from the electrolyte, said system having, a hydrate former pump means associated with the store means and being operative to intermix halogen gas with aqueous electrolyte to form halogen hydrate, said hydrate former means including, multiple outlet nozzle means connected with the outlet side of said pump means and being operative to minimize plugging, said nozzle means being comprised of at least one divider means which is generally perpendicular to the rotational axes of gears within the pump means, said divider means acting to divide the flow from the pump means into multiple outlet flow paths.

  20. Multiple sclerosis: Therapeutic applications of advancing drug delivery systems.

    PubMed

    Dolati, Sanam; Babaloo, Zohreh; Jadidi-Niaragh, Farhad; Ayromlou, Hormoz; Sadreddini, Sanam; Yousefi, Mehdi

    2017-02-01

    Multiple sclerosis (MS) is an inflammatory autoimmune disease of the central nervous system, which is accompanying with demyelination, neurodegeneration and sensibility to oxidative stress. In MS, auto-reactive lymphocytes cross the blood-brain barrier (BBB) and reside in the perivenous demyelinating lesions which create various distinct inflammatory demyelinated plaques situated predominantly in the white matter. The current MS-related therapeutic approaches can be classified into disease-modifying therapies (DMTs) and symptomatic therapy. DMTs suppress circulating immune cells, inhibit passing the BBB and decrease the inflammatory responses. Recent advances have remarkably delayed disease development and improved the quality of life for numerous patients. In spite of major improvements in therapeutic options, there are some limitations regarding the routes of administration and the necessity for repeated and long-term dosing in which cause to systemic disadvantageous consequences and patient non-compliance. Nanotechnology presents promising approaches to improve autoimmune disease treatment with the capability to overcome many of the limitations common to the current immunosuppressive and biological therapies. Here we emphasis on nanomedicine-based drug delivery approaches of biological immunomodulatory mediators for the treatment of multiple sclerosis. This comprehensive review details the most successful drugs in MS therapy and also focuses on conceptions and clinical potential of novel nanomedicine attitudes for inducing immunosuppression and immunological tolerance in MS to modulate abnormal and pathologic immune responses.

  1. Diagnostic accuracy of an ultrasonic multiple transducer cardiac imaging system

    NASA Technical Reports Server (NTRS)

    Popp, R. L.; Brown, O. R.; Harrison, D. C.

    1975-01-01

    An ultrasonic multiple-transducer imaging system for intracardiac structure visualization is developed in order to simplify visualization of the human heart in vivo without radiation hazard or invasion of the body. Results of the evaluation of the diagnostic accuracy of the devised system in a clinical setting for adult patients are presented and discussed. Criteria are presented for recognition of mitral valva prolapse, mitral stenosis, pericardial effusion, atrial septal defect, and left ventricular dyssynergy. The probable cause for false-positive and false-negative diagnoses is discussed. However, hypertrophic myopathy and congestive myopathy were unable to be detected. Since only qualitative criteria were used, it was not possible to differentiate patients with left ventricular volume overload from patients without cardiac pathology.

  2. The Gas6/TAM System and Multiple Sclerosis

    PubMed Central

    Bellan, Mattia; Pirisi, Mario; Sainaghi, Pier Paolo

    2016-01-01

    Growth arrest specific 6 (Gas6) is a multimodular circulating protein, the biological actions of which are mediated by the interaction with three transmembrane tyrosine kinase receptors: Tyro3, Axl, and MerTK, collectively named TAM. Over the last few decades, many progresses have been done in the understanding of the biological activities of this highly pleiotropic system, which plays a role in the regulation of immune response, inflammation, coagulation, cell growth, and clearance of apoptotic bodies. Recent findings have further related Gas6 and TAM receptors to neuroinflammation in general and, specifically, to multiple sclerosis (MS). In this paper, we review the biology of the Gas6/TAM system and the current evidence supporting its potential role in the pathogenesis of MS. PMID:27801848

  3. The nature of the autonomic dysfunction in multiple system atrophy

    NASA Technical Reports Server (NTRS)

    Parikh, Samir M.; Diedrich, Andre; Biaggioni, Italo; Robertson, David

    2002-01-01

    The concept that multiple system atrophy (MSA, Shy-Drager syndrome) is a disorder of the autonomic nervous system is several decades old. While there has been renewed interest in the movement disorder associated with MSA, two recent consensus statements confirm the centrality of the autonomic disorder to the diagnosis. Here, we reexamine the autonomic pathophysiology in MSA. Whereas MSA is often thought of as "autonomic failure", new evidence indicates substantial persistence of functioning sympathetic and parasympathetic nerves even in clinically advanced disease. These findings help explain some of the previously poorly understood features of MSA. Recognition that MSA entails persistent, constitutive autonomic tone requires a significant revision of our concepts of its diagnosis and therapy. We will review recent evidence bearing on autonomic tone in MSA and discuss their therapeutic implications, particularly in terms of the possible development of a bionic baroreflex for better control of blood pressure.

  4. Multiple Chaos Synchronization System for Power Quality Classification in a Power System

    PubMed Central

    Huang, Cong-Hui; Lin, Chia-Hung

    2014-01-01

    This document proposes multiple chaos synchronization (CS) systems for power quality (PQ) disturbances classification in a power system. Chen-Lee based CS systems use multiple detectors to track the dynamic errors between the normal signal and the disturbance signal, including power harmonics, voltage fluctuation phenomena, and voltage interruptions. Multiple detectors are used to monitor the dynamic errors between the master system and the slave system and are used to construct the feature patterns from time-domain signals. The maximum likelihood method (MLM), as a classifier, performs a comparison of the patterns of the features in the database. The proposed method can adapt itself without the need for adjustment of parameters or iterative computation. For a sample power system, the test results showed accurate discrimination, good robustness, and faster processing time for the detection of PQ disturbances. PMID:24764771

  5. A Microprocessor-Based, Solar Cell Parameter Measurement System

    DTIC Science & Technology

    1988-06-01

    solar cell I - V curves ........................... 31 Figure 8. Sample 2, silicon solar cell I - V curves...32 Figure 9. Sample gallium-arsenide solar cell I - V curves ..................... 33 Figure 10. Practical versus ideal binary fractional...Sherif Michael and Robert Callaway developed a simple circuit for the meas- urement of a solar cell I - V curve at the Naval Postgraduate School

  6. Distributed Micro-Processor Applications to Guidance and Control Systems.

    DTIC Science & Technology

    1982-07-01

    Continuously stimulating advances in the aerospace sciences relevant to strengthening the common defence posture; - Improving the co-operation among member...promises to be equally amazing. There appears to be another three orders of magnitude improvement before we reach saturation limits due to inherent...using x-rays for achieving 0.3 micron feature size promise significant improvements in the speed power products for operational microcircuits in the

  7. A Continuously Reconfiguring Multi-Microprocessor Flight Control System.

    DTIC Science & Technology

    1981-05-01

    an architecture and control law consultant on the project. In 1981, Lt. Jack Crotty joined the program as a software designer thereby completing the...processor and helped to develop the CRMmFCS control laws and corresponding aircraft simulation. Mark Mears was iii responsible for the haidware and...for development of the real-world plant simulation and overall control law design. He also organized a national workshop on multi-processor flight

  8. Simultaneous Real-Time Monitoring of Multiple Cortical Systems

    PubMed Central

    Gupta, Disha; Hill, N. Jeremy; Brunner, Peter; Gunduz, Aysegul; Ritaccio, Anthony L.; Schalk, Gerwin

    2014-01-01

    Objective Real-time monitoring of the brain is potentially valuable for performance monitoring, communication, training or rehabilitation. In natural situations, the brain performs a complex mix of various sensory, motor, or cognitive functions. Thus, real-time brain monitoring would be most valuable if (a) it could decode information from multiple brain systems simultaneously, and (b) this decoding of each brain system were robust to variations in the activity of other (unrelated) brain systems. Previous studies showed that it is possible to decode some information from different brain systems in retrospect and/or in isolation. In our study, we set out to determine whether it is possible to simultaneously decode important information about a user from different brain systems in real time, and to evaluate the impact of concurrent activity in different brain systems on decoding performance. Approach We study these questions using electrocorticographic (ECoG) signals recorded in humans. We first document procedures for generating stable decoding models given little training data, and then report their use for offline and for real-time decoding from 12 subjects (6 for offline parameter optimization, 6 for online experimentation). The subjects engage in tasks that involve movement intention, movement execution and auditory functions, separately, and then simultaneously. Main results Our real-time results demonstrate that our system can identify intention and movement periods in single trials with an accuracy of 80.4% and 86.8%, respectively (where 50% would be expected by chance). Simultaneously, the decoding of the power envelope of an auditory stimulus resulted in an average correlation coefficient of 0.37 between the actual and decoded power envelope. These decoders were trained separately and executed simultaneously in real time. Significance This study yielded the first demonstration that it is possible to decode simultaneously the functional activity of multiple

  9. Actively controlled multiple-sensor system for feature extraction

    NASA Astrophysics Data System (ADS)

    Daily, Michael J.; Silberberg, Teresa M.

    1991-08-01

    Typical vision systems which attempt to extract features from a visual image of the world for the purposes of object recognition and navigation are limited by the use of a single sensor and no active sensor control capability. To overcome limitations and deficiencies of rigid single sensor systems, more and more researchers are investigating actively controlled, multisensor systems. To address these problems, we have developed a self-calibrating system which uses active multiple sensor control to extract features of moving objects. A key problem in such systems is registering the images, that is, finding correspondences between images from cameras of differing focal lengths, lens characteristics, and positions and orientations. The authors first propose a technique which uses correlation of edge magnitudes for continuously calibrating pan and tilt angles of several different cameras relative to a single camera with a wide angle field of view, which encompasses the views of every other sensor. A simulation of a world of planar surfaces, visual sensors, and a robot platform used to test active control for feature extraction is then described. Motion in the field of view of at least one sensor is used to center the moving object for several sensors, which then extract object features such as color, boundary, and velocity from the appropriate sensors. Results are presented from real cameras and from the simulated world.

  10. Handheld camera 3D modeling system using multiple reference panels

    NASA Astrophysics Data System (ADS)

    Fujimura, Kouta; Oue, Yasuhiro; Terauchi, Tomoya; Emi, Tetsuichi

    2002-03-01

    A novel 3D modeling system in which a target object is easily captured and modeled by using a hand-held camera with several reference panels is presented in this paper. The reference panels are designed to be able to obtain the camera position and discriminate between each other. A conventional 3D modeling system using a reference panel has several restrictions regarding the target object, specifically the size and its location. Our system uses multiple reference panels, which are set around the target object to remove these restrictions. The main features of this system are as follows: 1) The whole shape and photo-realistic textures of the target object can be digitized based on several still images or a movie captured by using a hand-held camera; as well as each location of the camera that can be calculated using the reference panels. 2) Our system can be provided as a software product only. That means there are no special requirements for hardware; even the reference panels , because they can be printed from image files or software. 3) This system can be applied to digitize a larger object. In the experiments, we developed and used an interactive region selection tool to detect the silhouette on each image instead of using the chroma -keying method. We have tested our system with a toy object. The calculation time is about 10 minutes (except for the capturing the images and extracting the silhouette by using our tool) on a personal computer with a Pentium-III processor (600MHz) and 320MB memory. However, it depends on how complex the images are and how many images you use. Our future plan is to evaluate the system with various kind of objects, specifically, large ones in outdoor environments.

  11. Predicting Flood Hazards in Systems with Multiple Flooding Mechanisms

    NASA Astrophysics Data System (ADS)

    Luke, A.; Schubert, J.; Cheng, L.; AghaKouchak, A.; Sanders, B. F.

    2014-12-01

    Delineating flood zones in systems that are susceptible to flooding from a single mechanism (riverine flooding) is a relatively well defined procedure with specific guidance from agencies such as FEMA and USACE. However, there is little guidance in delineating flood zones in systems that are susceptible to flooding from multiple mechanisms such as storm surge, waves, tidal influence, and riverine flooding. In this study, a new flood mapping method which accounts for multiple extremes occurring simultaneously is developed and exemplified. The study site in which the method is employed is the Tijuana River Estuary (TRE) located in Southern California adjacent to the U.S./Mexico border. TRE is an intertidal coastal estuary that receives freshwater flows from the Tijuana River. Extreme discharge from the Tijuana River is the primary driver of flooding within TRE, however tide level and storm surge also play a significant role in flooding extent and depth. A comparison between measured flows at the Tijuana River and ocean levels revealed a correlation between extreme discharge and ocean height. Using a novel statistical method based upon extreme value theory, ocean heights were predicted conditioned up extreme discharge occurring within the Tijuana River. This statistical technique could also be applied to other systems in which different factors are identified as the primary drivers of flooding, such as significant wave height conditioned upon tide level, for example. Using the predicted ocean levels conditioned upon varying return levels of discharge as forcing parameters for the 2D hydraulic model BreZo, the 100, 50, 20, and 10 year floodplains were delineated. The results will then be compared to floodplains delineated using the standard methods recommended by FEMA for riverine zones with a downstream ocean boundary.

  12. Formal proof of the AVM-1 microprocessor using the concept of generic interpreters

    NASA Technical Reports Server (NTRS)

    Windley, P.; Levitt, K.; Cohen, G. C.

    1991-01-01

    A microprocessor designated AVM-1 was designed to demonstrate the use of generic interpreters in verifying hierarchically decomposed microprocessor specifications. This report is intended to document the high-order language (HOL) code verifying AVM-1. The organization of the proof is discussed and some technical details concerning the execution of the proof scripts in HOL are presented. The proof scripts used to verify AVM-1 are also presented.

  13. Systemic Mastocytosis with Smoldering Multiple Myeloma: Report of a Case.

    PubMed

    Ghanem, Sassine; Garcia, Gwenalyn; Ying, Liu; Hurford, Matthew; Odaimi, Marcel

    2016-01-01

    Systemic mastocytosis (SM) is a disease characterized by a clonal infiltration of mast cells affecting various tissues of the body. It is grouped into six different subtypes according to the World Health Organization classification. It is called indolent systemic mastocytosis (ISM) when there is no evidence of end organ dysfunction, while the presence of end organ dysfunction defines aggressive systemic mastocytosis (ASM). When SM coexists with a clonal hematological disorder, it is classified as systemic mastocytosis with associated clonal hematological nonmast cell lineage disease (SM-AHNMD). Over 80% of SM-AHNMD cases involve disorders of the myeloid cell lines. To our knowledge, there are only 8 reported cases to date of SM associated with a plasma cell disorder. We report a patient with ISM who was found to have concomitant smoldering multiple myeloma. His disease later progressed to ASM. We discuss this rare association between SM and a plasma cell disorder, and potential common pathophysiologic mechanisms linking the two disorders will be reviewed. We also discuss prognostic factors in SM as well as the management options considered during the evolution of the patient's disease.

  14. Supporting Multiple Cognitive Processing Styles Using Tailored Support Systems

    SciTech Connect

    Tuan Q. Tran; Karen M. Feigh; Amy R. Pritchett

    2007-08-01

    According to theories of cognitive processing style or cognitive control mode, human performance is more effective when an individual’s cognitive state (e.g., intuition/scramble vs. deliberate/strategic) matches his/her ecological constraints or context (e.g., utilize intuition to strive for a "good-enough" response instead of deliberating for the "best" response under high time pressure). Ill-mapping between cognitive state and ecological constraints are believed to lead to degraded task performance. Consequently, incorporating support systems which are designed to specifically address multiple cognitive and functional states e.g., high workload, stress, boredom, and initiate appropriate mitigation strategies (e.g., reduce information load) is essential to reduce plant risk. Utilizing the concept of Cognitive Control Models, this paper will discuss the importance of tailoring support systems to match an operator's cognitive state, and will further discuss the importance of these ecological constraints in selecting and implementing mitigation strategies for safe and effective system performance. An example from the nuclear power plant industry illustrating how a support system might be tailored to support different cognitive states is included.

  15. Systemic Mastocytosis with Smoldering Multiple Myeloma: Report of a Case

    PubMed Central

    Garcia, Gwenalyn; Ying, Liu; Hurford, Matthew; Odaimi, Marcel

    2016-01-01

    Systemic mastocytosis (SM) is a disease characterized by a clonal infiltration of mast cells affecting various tissues of the body. It is grouped into six different subtypes according to the World Health Organization classification. It is called indolent systemic mastocytosis (ISM) when there is no evidence of end organ dysfunction, while the presence of end organ dysfunction defines aggressive systemic mastocytosis (ASM). When SM coexists with a clonal hematological disorder, it is classified as systemic mastocytosis with associated clonal hematological nonmast cell lineage disease (SM-AHNMD). Over 80% of SM-AHNMD cases involve disorders of the myeloid cell lines. To our knowledge, there are only 8 reported cases to date of SM associated with a plasma cell disorder. We report a patient with ISM who was found to have concomitant smoldering multiple myeloma. His disease later progressed to ASM. We discuss this rare association between SM and a plasma cell disorder, and potential common pathophysiologic mechanisms linking the two disorders will be reviewed. We also discuss prognostic factors in SM as well as the management options considered during the evolution of the patient's disease. PMID:27293930

  16. Multiple Classifier System for Remote Sensing Image Classification: A Review

    PubMed Central

    Du, Peijun; Xia, Junshi; Zhang, Wei; Tan, Kun; Liu, Yi; Liu, Sicong

    2012-01-01

    Over the last two decades, multiple classifier system (MCS) or classifier ensemble has shown great potential to improve the accuracy and reliability of remote sensing image classification. Although there are lots of literatures covering the MCS approaches, there is a lack of a comprehensive literature review which presents an overall architecture of the basic principles and trends behind the design of remote sensing classifier ensemble. Therefore, in order to give a reference point for MCS approaches, this paper attempts to explicitly review the remote sensing implementations of MCS and proposes some modified approaches. The effectiveness of existing and improved algorithms are analyzed and evaluated by multi-source remotely sensed images, including high spatial resolution image (QuickBird), hyperspectral image (OMISII) and multi-spectral image (Landsat ETM+). Experimental results demonstrate that MCS can effectively improve the accuracy and stability of remote sensing image classification, and diversity measures play an active role for the combination of multiple classifiers. Furthermore, this survey provides a roadmap to guide future research, algorithm enhancement and facilitate knowledge accumulation of MCS in remote sensing community. PMID:22666057

  17. Multiple classifier system for remote sensing image classification: a review.

    PubMed

    Du, Peijun; Xia, Junshi; Zhang, Wei; Tan, Kun; Liu, Yi; Liu, Sicong

    2012-01-01

    Over the last two decades, multiple classifier system (MCS) or classifier ensemble has shown great potential to improve the accuracy and reliability of remote sensing image classification. Although there are lots of literatures covering the MCS approaches, there is a lack of a comprehensive literature review which presents an overall architecture of the basic principles and trends behind the design of remote sensing classifier ensemble. Therefore, in order to give a reference point for MCS approaches, this paper attempts to explicitly review the remote sensing implementations of MCS and proposes some modified approaches. The effectiveness of existing and improved algorithms are analyzed and evaluated by multi-source remotely sensed images, including high spatial resolution image (QuickBird), hyperspectral image (OMISII) and multi-spectral image (Landsat ETM+). Experimental results demonstrate that MCS can effectively improve the accuracy and stability of remote sensing image classification, and diversity measures play an active role for the combination of multiple classifiers. Furthermore, this survey provides a roadmap to guide future research, algorithm enhancement and facilitate knowledge accumulation of MCS in remote sensing community.

  18. A genome-wide association study in multiple system atrophy

    PubMed Central

    Sailer, Anna; Nalls, Michael A.; Schulte, Claudia; Federoff, Monica; Price, T. Ryan; Lees, Andrew; Ross, Owen A.; Dickson, Dennis W.; Mok, Kin; Mencacci, Niccolo E.; Schottlaender, Lucia; Chelban, Viorica; Ling, Helen; O'Sullivan, Sean S.; Wood, Nicholas W.; Traynor, Bryan J.; Ferrucci, Luigi; Federoff, Howard J.; Mhyre, Timothy R.; Morris, Huw R.; Deuschl, Günther; Quinn, Niall; Widner, Hakan; Albanese, Alberto; Infante, Jon; Bhatia, Kailash P.; Poewe, Werner; Oertel, Wolfgang; Höglinger, Günter U.; Wüllner, Ullrich; Goldwurm, Stefano; Pellecchia, Maria Teresa; Ferreira, Joaquim; Tolosa, Eduardo; Bloem, Bastiaan R.; Rascol, Olivier; Meissner, Wassilios G.; Hardy, John A.; Revesz, Tamas; Holton, Janice L.; Gasser, Thomas; Wenning, Gregor K.; Singleton, Andrew B.

    2016-01-01

    Objective: To identify genetic variants that play a role in the pathogenesis of multiple system atrophy (MSA), we undertook a genome-wide association study (GWAS). Methods: We performed a GWAS with >5 million genotyped and imputed single nucleotide polymorphisms (SNPs) in 918 patients with MSA of European ancestry and 3,864 controls. MSA cases were collected from North American and European centers, one third of which were neuropathologically confirmed. Results: We found no significant loci after stringent multiple testing correction. A number of regions emerged as potentially interesting for follow-up at p < 1 × 10−6, including SNPs in the genes FBXO47, ELOVL7, EDN1, and MAPT. Contrary to previous reports, we found no association of the genes SNCA and COQ2 with MSA. Conclusions: We present a GWAS in MSA. We have identified several potentially interesting gene loci, including the MAPT locus, whose significance will have to be evaluated in a larger sample set. Common genetic variation in SNCA and COQ2 does not seem to be associated with MSA. In the future, additional samples of well-characterized patients with MSA will need to be collected to perform a larger MSA GWAS, but this initial study forms the basis for these next steps. PMID:27629089

  19. Post-transcriptional control of DGCR8 expression by the Microprocessor

    PubMed Central

    Triboulet, Robinson; Chang, Hao-Ming; LaPierre, Robert J.; Gregory, Richard I.

    2009-01-01

    The Microprocessor, comprising the RNase III Drosha and the double-stranded RNA binding protein DGCR8, is essential for microRNA (miRNA) biogenesis. In the miRNA processing pathway certain hairpin structures within primary miRNA (pri-miRNA) transcripts are specifically cleaved by the Microprocessor to release ∼60–70-nucleotide precursor miRNA (pre-miRNA) intermediates. Although both Drosha and DGCR8 are required for Microprocessor activity, the mechanisms regulating the expression of these proteins are unknown. Here we report that the Microprocessor negatively regulates DGCR8 expression. Using in vitro reconstitution and in vivo studies, we demonstrate that a hairpin, localized in the 5′ untranslated region (5′UTR) of DGCR8 mRNA, is cleaved by the Microprocessor. Accordingly, knockdown of Drosha leads to an increase in DGCR8 mRNA and protein levels in cells. Furthermore, we found that the DGCR8 5′UTR confers Microprocessor-dependent repression of a luciferase reporter gene in vivo. Our results uncover a novel feedback loop that regulates DGCR8 levels. PMID:19383765

  20. Post-transcriptional control of DGCR8 expression by the Microprocessor.

    PubMed

    Triboulet, Robinson; Chang, Hao-Ming; Lapierre, Robert J; Gregory, Richard I

    2009-06-01

    The Microprocessor, comprising the RNase III Drosha and the double-stranded RNA binding protein DGCR8, is essential for microRNA (miRNA) biogenesis. In the miRNA processing pathway certain hairpin structures within primary miRNA (pri-miRNA) transcripts are specifically cleaved by the Microprocessor to release approximately 60-70-nucleotide precursor miRNA (pre-miRNA) intermediates. Although both Drosha and DGCR8 are required for Microprocessor activity, the mechanisms regulating the expression of these proteins are unknown. Here we report that the Microprocessor negatively regulates DGCR8 expression. Using in vitro reconstitution and in vivo studies, we demonstrate that a hairpin, localized in the 5' untranslated region (5'UTR) of DGCR8 mRNA, is cleaved by the Microprocessor. Accordingly, knockdown of Drosha leads to an increase in DGCR8 mRNA and protein levels in cells. Furthermore, we found that the DGCR8 5'UTR confers Microprocessor-dependent repression of a luciferase reporter gene in vivo. Our results uncover a novel feedback loop that regulates DGCR8 levels.

  1. Implementation of a Real-Time, Distributed Operating System for a Multiple Computer System.

    DTIC Science & Technology

    1982-06-01

    Segmentation Registers ------ 31 4. The iSBC8O86/12A( Single Board Computer ) ------ 35 C. PHYSICAL ADDRESS GENERATION ---------------------- 36 1. General...iSBC86/12A single board computer (SBC). It is based on the INTEL 8086 16 bit micro-processor. Detailed descriptions of all the components of the SBC and...space. The extra segment register (ES) is typically used for external or shared data, and data storage. 4. The iSBC86/12A( Single Board Computer ) The

  2. Single transmission line interrogated multiple channel data acquisition system

    DOEpatents

    Fasching, George E.; Keech, Jr., Thomas W.

    1980-01-01

    A single transmission line interrogated multiple channel data acquisition system is provided in which a plurality of remote station/sensor circuits each monitors a specific process variable and each transmits measurement values over a single transmission line to a master interrogating station when addressed by said master interrogating station. Typically, as many as 330 remote stations may be parallel connected to the transmission line which may exceed 7,000 feet. The interrogation rate is typically 330 stations/second. The master interrogating station samples each station according to a shared, charging transmit-receive cycle. All remote station address signals, all data signals from the remote stations/sensors and all power for all of the remote station/sensors are transmitted via a single continuous terminated coaxial cable. A means is provided for periodically and remotely calibrating all remote sensors for zero and span. A provision is available to remotely disconnect any selected sensor station from the main transmission line.

  3. Redundancy management of multiple inertial systems for Space Shuttle.

    NASA Technical Reports Server (NTRS)

    Dove, D. W.; Mckern, R. A.

    1972-01-01

    Failure detection and isolation techniques are developed for application to off-the-shelf type four-gimbaled inertial measurement units such as the KT-70 or Carousel IV. By using simulated boost and entry shuttle trajectories with specific gimbaled IMU models, failure detection thresholds are developed based upon red-line life dependent requirements and warning thresholds are given within the red-line thresholds based upon expected worst case IMU performance. Using these trajectories, established trajectory thresholds, and multiple IMU models, various failure detection and isolation techniques are evaluated for application in both powered and unpowered flight phases. The adequacy of off-the-shelf systems for both attitude and velocity detection methods is evaluated and recommendations for shuttle application are made.

  4. Multiple system atrophy--the nature of the beast.

    PubMed Central

    Quinn, N

    1989-01-01

    Multiple system atrophy (MSA) is generally considered a rare disease, but may account for up to 10% of patients with Parkinsonism. The profusion of names for this disease, which may present to general physicians, psychiatrists, cardiologists, autonomic specialists, general neurologists and those with a special interest in Parkinsonism (this author's own perspective) or cerebellar disorders, together with ignorance of its protean manifestations, may account for its underrecognition and misdiagnosis. In this article, the history and nosology of the condition are considered, and provisional diagnostic criteria are advanced. The usefulness (or otherwise) of ancillary investigations is addressed, and the shortcomings of current methods of treatment are stressed. As with idiopathic Parkinson's disease, the ultimate goal of eradicating the disease entails better diagnosis in order to establish the cause, and thence to develop a radical treatment capable of preventing or arresting the disease process. PMID:2666581

  5. Multiple system atrophy: current and future approaches to management

    PubMed Central

    Flabeau, Olivier; Meissner, Wassilios G.; Tison, François

    2010-01-01

    Multiple system atrophy (MSA) is a rare neurodegenerative disorder without any effective treatment in slowing or stopping disease progression. It is characterized by poor levodopa responsive Parkinsonism, cerebellar ataxia, pyramidal signs and autonomic failure in any combination. Current therapeutic strategies are primarily based on dopamine replacement and improvement of autonomic failure. However, symptomatic management remains disappointing and no curative treatment is yet available. Recent experimental evidence has confirmed the key role of alpha-synuclein aggregation in the pathogenesis of MSA. Referring to this hypothesis, transgenic and toxic animal models have been developed to assess candidate drugs for MSA. The standardization of diagnosis criteria and assessment procedures will allow large multicentre clinical trials to be conducted. In this article we review the available symptomatic treatment, recent results of studies investigating potential neuroprotective drugs, and future approaches for the management in MSA. PMID:21179616

  6. Anhidrosis in multiple system atrophy: a preganglionic sudomotor dysfunction?

    PubMed

    Donadio, Vincenzo; Nolano, Maria; Elam, Mikael; Montagna, Pasquale; Provitera, Vincenzo; Bugiardini, Enrico; Baruzzi, Agostino; Santoro, Lucio; Liguori, Rocco

    2008-04-30

    Anhidrosis occurs in the majority of multiple system atrophy (MSA) patients but the underlying site of lesion is not well established. We describe three patients with long-standing MSA and anhidrosis diagnosed on the basis of a thermoregulatory sweating test. In biopsies of anhidrotic skin, immunofluorescence analysis disclosed a well preserved postganglionic sudomotor innervation in all three patients supporting the hypothesis of a preganglionic nerve fiber lesion underlying their anhidrosis. Postganglionic sudomotor fiber integrity was also confirmed by normal electrodermal responses in one patient, whereas such responses and microneurographically detectable skin sympathetic nerve activity were absent in the other two MSA patients, suggesting a functional inactivity of structurally intact postganglionic sympathetic skin fibers.

  7. Simultaneous multiple degrees of freedom (DoF) measurement system

    NASA Astrophysics Data System (ADS)

    Molnar, G.; Strube, S.; Köchert, P.; Danzebrink, H.-U.; Flügge, J.

    2016-08-01

    This paper presents a newly developed highly accurate interferometric 6° of freedom (DoF) measurement system with Ångström resolution for displacement and μrad resolution for angle measurement, respectively. The new interferometer is based on a modified homodyne Twyman-Green interferometer concept. It uses a novel signal acquisition and processing approach whereby a spatial interferogram is captured by a CMOS camera and the registered fringe pattern is transformed into its frequency spectrum [1]. The spectral representation of a movement of e.g. a positioning stage is analyzed for its major components: the phase information directly correlates with the displacement of the stage, while a possible rotational motion causes a shift in the frequency spectrum. The developed compact 6 DoF head uses multiple rays in parallel to detect x-y-z displacements and roll-pitch-yaw movements.

  8. Multiple System Atrophy: A Clinical and Neuropathological Perspective

    PubMed Central

    Ubhi, Kiren; Low, Phillip; Masliah, Eliezer

    2011-01-01

    Multiple System Atrophy (MSA) is a neurodegenerative disease presenting with motor abnormalities including akinesia, rigidity and postural instability. Whilst improved diagnostic criteria have aided accurate diagnosis of MSA, understanding of neuropathological aspects underlying MSA was bolstered by the identification of alpha-synuclein (α-syn) as the primary constituent of the abnormal protein aggregations observed in the brains of MSA patients. The generation of transgenic animal models of MSA coupled with an increasing understanding of the biochemical structure and function of α-syn has highlighted a number of key pathological pathways thought to underlie the neurodegeneration observed in MSA. This review will summarize key findings in the field, discuss current areas of debate and describe current experimental approaches towards disease-modifying therapies. PMID:21962754

  9. Operational effectiveness of a Multiple Aquila Control System (MACS)

    NASA Technical Reports Server (NTRS)

    Brown, R. W.; Flynn, J. D.; Frey, M. R.

    1983-01-01

    The operational effectiveness of a multiple aquila control system (MACS) was examined under a variety of remotely piloted vehicle (RPV) mission configurations. The set of assumptions and inputs used to form the rules under which a computerized simulation of MACS was run is given. The characteristics that are to govern MACS operations include: the battlefield environment that generates the requests for RPV missions, operating time-lines of the RPV-peculiar equipment, maintenance requirements, and vulnerability to enemy fire. The number of RPV missions and the number of operation days are discussed. Command, control, and communication data rates are estimated by determining how many messages are passed and what information is necessary in them to support ground coordination between MACS sections.

  10. A Spectroscopic and Mineralogical Study of Multiple Asteroid Systems

    NASA Astrophysics Data System (ADS)

    Lindsay, Sean S.; Emery, J. P.; Marchis, F.; Enriquez, J.; Assafin, M.

    2013-10-01

    There are currently ~200 identified multiple asteroid systems (MASs). These systems display a large diversity in heliocentric distance, size/mass ratio, system angular momentum, mutual orbital parameters, and taxonomic class. These characteristics are simplified under the nomenclature of Descamps and Marchis (2008), which divides MASs into four types: Type-1 - large asteroids with small satellites; Type-2 - similar size double asteroids; Type-3 - small asynchronous systems; and Type-4 - contact-binary asteroids. The large MAS diversity suggests multiple formation mechanisms are required to understand their origins. There are currently three broad formation scenarios: 1) ejecta from impacts; 2) catastrophic disruption followed by rotational fission; and 3) tidal disruption. The taxonomic class and mineralogy of the MASs coupled with the average density and system angular momentum provide a potential means to discriminate between proposed formation mechanisms. We present visible and near-infrared (NIR) spectra spanning 0.45 - 2.45 μm for 23 Main Belt MASs. The data were primarily obtained using the Southern Astrophysical Research Telescope (SOAR) Goodman High Throughput Spectrograph (August 2011 - July 2012) for the visible data and the InfraRed Telescope Facility (IRTF) SpeX Spectrograph (August 2008 - May 2013) for the IR data. Our data were supplemented using previously published data when necessary. The asteroids' Bus-DeMeo taxonomic classes are determined using the MIT SMASS online classification routines. Our sample includes 3 C-types, 1 X-type, 1 K-type, 1 L-type, 4 V-types, 10 S-types, 2 Sq- or Q-types, and 1 ambiguous classification. We calculate the 1- and 2-μm band centers, depths, and areas to determine the pyroxene mineralogy (molar Fs and Wo) of the surfaces using empirically derived equations. The NIR band analysis allows us to determine the S-type subclasses, S(I) - S(VII), which roughly tracks olivine-pyroxene chemistry. A comparison of the orbital

  11. Fast 3D multiple fan-beam CT systems

    NASA Astrophysics Data System (ADS)

    Kohlbrenner, Adrian; Haemmerle, Stefan; Laib, Andres; Koller, Bruno; Ruegsegger, Peter

    1999-09-01

    Two fast, CCD-based three-dimensional CT scanners for in vivo applications have been developed. One is designed for small laboratory animals and has a voxel size of 20 micrometer, while the other, having a voxel size of 80 micrometer, is used for human examinations. Both instruments make use of a novel multiple fan-beam technique: radiation from a line-focus X-ray tube is divided into a stack of fan-beams by a 28 micrometer pitch foil collimator. The resulting wedge-shaped X-ray field is the key to the instrument's high scanning speed and allows to position the sample close to the X-ray source, which makes it possible to build compact CT systems. In contrast to cone- beam scanners, the multiple fan-beam scanner relies on standard fan-beam algorithms, thereby eliminating inaccuracies in the reconstruction process. The projections from one single rotation are acquired within 2 min and are subsequently reconstructed into a 1024 X 1024 X 255 voxel array. Hence a single rotation about the sample delivers a 3D image containing a quarter of a billion voxels. Such volumetric images are 6.6 mm in height and can be stacked on top of each other. An area CCD sensor bonded to a fiber-optic light guide acts as a detector. Since no image intensifier, conventional optics or tapers are used throughout the system, the image is virtually distortion free. The scanner's high scanning speed and high resolution at moderately low radiation dose are the basis for reliable time serial measurements and analyses.

  12. The early-type multiple system QZ Carinae

    NASA Astrophysics Data System (ADS)

    Mayer, P.; Lorenz, R.; Drechsel, H.; Abseim, A.

    2001-02-01

    We present an analysis of the early-type quadruple system QZ Car, consisting of an eclipsing and a non-eclipsing binary. The spectroscopic investigation is based on new high dispersion echelle and CAT/CES spectra of H and He lines. The elements for the orbit of the non-eclipsing pair could be refined. Lines of the brighter component of the eclipsing binary were detected in near-quadrature spectra, while signatures of the fainter component could be identified in only few spectra. Lines of the primary component of the non-eclipsing pair and of both components of the eclipsing pair were found to be variable in position and strength; in particular, the He ii 4686 emission line of the brighter eclipsing component is strongly variable. An ephemeris for the eclipsing binary QZ Car valid at present was derived Prim. Min. = hel. JD 2448687.16 + 5fd9991 * E. The relative orbit of the two binary constituents of the multiple system is discussed. In contrast to earlier investigations we found radial velocity changes of the systemic velocities of both binaries, which were used - together with an O-C analysis of the expected light-time effect - to derive approximate parameters of the mutual orbit of the two pairs. It is shown that this orbit and the distance to QZ Car can be further refined by minima timing and interferometry. Based on observations collected at the European Southern Observatory, La Silla, Chile.

  13. A Multiple-Channel Sub-Band Transient Detection System

    SciTech Connect

    David A. Smith

    1998-11-01

    We have developed a unique multiple-channel sub-band transient detection system to record transient electromagnetic signals in carrier-dominated radio environments; the system has been used to make unique observations of weak, transient HF signals. The detection system has made these observations possible through improved sensitivity compared to conventional broadband transient detection systems; the sensitivity improvement is estimated to be at least 20 dB. The increase in sensitivity has been achieved through subdivision of the band of interest (an 18 MHz tunable bandwidth) into eight sub-band independent detection channels, each with a 400 kHz bandwidth and its own criteria. The system generates a system trigger signal when a predetermined number of channels (typically five) trigger within a predetermined window of time (typically 100 ~s). Events are recorded with a broadband data acquisition system sampling at 50 or 100 Msample/s, so despite the fact that the detection system operates on portions of the signal confined to narrow bands, data acquisition is broadband. Between May and September of 1994, the system was used to detect and record over six thousand transient events in the frequency band from 3 to 30 MHz. Approximately 500 of the events have been characterized as paired bursts of radio noise with individual durations of 2 to 10 ps and separations between the bursts of 5 to 160 ps. The paired transients are typically 5 to 40 dB brighter than the background electromagnetic spectrum between carrier signals. We have termed these events SubIonospheric Pulse Pairs (SIPPS) and presently have no explanation as to their source. Our observations of SIPPS resemble observations of TransIonospheric Pulse Pairs (TIPPs) recorded by the Blackboard instrument on the ALEXIS satellite; the source of TIPP events is also unknown. Most of the recorded SIPP events do not exhibit frequency dispersion, implying propagation along a line-of-sight (groundwave) path; but seven of

  14. Music recommendation system for biofied building considering multiple residents

    NASA Astrophysics Data System (ADS)

    Ito, Takahiro; Mita, Akira

    2012-04-01

    This research presents a music recommendation system based on multiple users' communication excitement and productivity. Evaluation is conducted on following two points. 1, Does songA recommended by the system improve the situation of dropped down communication excitement? 2, Does songB recommended by the system improve the situation of dropped down and productivity of collaborative work? The objective of this system is to recommend songs which shall improve the situation of dropped down communication excitement and productivity. Songs are characterized according to three aspects; familiarity, relaxing and BPM(Beat Per Minutes). Communication excitement is calculated from speech data obtained by an audio sensor. Productivity of collaborative brainstorming is manually calculated by the number of time-series key words during mind mapping. First experiment was music impression experiment to 118 students. Based on 1, average points of familiarity, relaxing and BPM 2, cronbach alpha factor, songA(high familiarity, high relaxing and high BPM song) and songB(high familiarity, high relaxing and low BPM) are selected. Exploratory experiment defined dropped down communication excitement and dropped down and productivity of collaborative work. Final experiment was conducted to 32 first meeting students divided into 8 groups. First 4 groups had mind mapping 1 while listening to songA, then had mind mapping 2 while listening songB. Following 4 groups had mind mapping 1 while listening to songB, then had mind mapping 2 while listening songA. Fianl experiment shows two results. Firstly, ratio of communication excitement between music listening section and whole brain storming is 1.27. Secondly, this system increases 69% of average productivity.

  15. Implementation of the DAST ARW II control laws using an 8086 microprocessor and an 8087 floating-point coprocessor. [drones for aeroelasticity research

    NASA Technical Reports Server (NTRS)

    Kelly, G. L.; Berthold, G.; Abbott, L.

    1982-01-01

    A 5 MHZ single-board microprocessor system which incorporates an 8086 CPU and an 8087 Numeric Data Processor is used to implement the control laws for the NASA Drones for Aerodynamic and Structural Testing, Aeroelastic Research Wing II. The control laws program was executed in 7.02 msec, with initialization consuming 2.65 msec and the control law loop 4.38 msec. The software emulator execution times for these two tasks were 36.67 and 61.18, respectively, for a total of 97.68 msec. The space, weight and cost reductions achieved in the present, aircraft control application of this combination of a 16-bit microprocessor with an 80-bit floating point coprocessor may be obtainable in other real time control applications.

  16. 3-D movies using microprocessor-controlled optoelectronic spectacles

    NASA Astrophysics Data System (ADS)

    Jacobs, Ken; Karpf, Ron

    2012-02-01

    Despite rapid advances in technology, 3-D movies are impractical for general movie viewing. A new approach that opens all content for casual 3-D viewing is needed. 3Deeps--advanced microprocessor controlled optoelectronic spectacles--provides such a new approach to 3-D. 3Deeps works on a different principle than other methods for 3-D. 3-D movies typically use the asymmetry of dual images to produce stereopsis, necessitating costly dual-image content, complex formatting and transmission standards, and viewing via a corresponding selection device. In contrast, all 3Deeps requires to view movies in realistic depth is an illumination asymmetry--a controlled difference in optical density between the lenses. When a 2-D movie has been projected for viewing, 3Deeps converts every scene containing lateral motion into realistic 3-D. Put on 3Deeps spectacles for 3-D viewing, or remove them for viewing in 2-D. 3Deeps works for all analogue and digital 2-D content, by any mode of transmission, and for projection screens, digital or analogue monitors. An example using aerial photography is presented. A movie consisting of successive monoscopic aerial photographs appears in realistic 3-D when viewed through 3Deeps spectacles.

  17. The tools of competition: Differentiation, segmentation and the microprocessor

    SciTech Connect

    Piepmeier, J.M. ); Jermain, D.O. ); Egnor, T.L. )

    1993-11-01

    The microprocessor enables electric utilities to recover product differentiation and market segmentation tools that they relinquished decades ago. These tools present a [open quotes]double-edged[close quotes] opportunity to the industry. Product differentiation and market segmentation are deeply and permanently embedded in the corporate strategy and culture of virtually every successful firm. Most electric utilities, however, continue to promote a generic product to an undifferentiated captive audience. This approach was also common in the pre-Yeltsin USSR, where advertisements simply read, Buy Beer, or Eat Potatoes'. Electric utilities relinquished the differentiation/segmentation function in the far distant past to the suppliers of end-use energy appliances such as GE and Carrier. By default they assigned themselves the role of commodity supplier. Historically, this role has been protected in the marketplace and insulated from competition by two strong barriers: economies of scale and status as a legally franchised monopoly in a well-defined geographic territory. These two barriers do not exist independently; the second depends on the first. When scale economies cease and then reverse, the industry's legally protected position in the marketplace begins to erode. The lack of product differentiation and market segmentation, which was inconsequential before, now becomes a serious handicap: These same relinquished tools seem to be essential for success in a competitive environment.

  18. Formal verification of a microcoded VIPER microprocessor using HOL

    NASA Technical Reports Server (NTRS)

    Levitt, Karl; Arora, Tejkumar; Leung, Tony; Kalvala, Sara; Schubert, E. Thomas; Windley, Philip; Heckman, Mark; Cohen, Gerald C.

    1993-01-01

    The Royal Signals and Radar Establishment (RSRE) and members of the Hardware Verification Group at Cambridge University conducted a joint effort to prove the correspondence between the electronic block model and the top level specification of Viper. Unfortunately, the proof became too complex and unmanageable within the given time and funding constraints, and is thus incomplete as of the date of this report. This report describes an independent attempt to use the HOL (Cambridge Higher Order Logic) mechanical verifier to verify Viper. Deriving from recent results in hardware verification research at UC Davis, the approach has been to redesign the electronic block model to make it microcoded and to structure the proof in a series of decreasingly abstract interpreter levels, the lowest being the electronic block level. The highest level is the RSRE Viper instruction set. Owing to the new approach and some results on the proof of generic interpreters as applied to simple microprocessors, this attempt required an effort approximately an order of magnitude less than the previous one.

  19. A Putative Multiple-Demand System in the Macaque Brain

    PubMed Central

    Bell, Andrew H.; Buckley, Mark J.; Mitchell, Anna S.; Sallet, Jerome; Duncan, John

    2016-01-01

    In humans, cognitively demanding tasks of many types recruit common frontoparietal brain areas. Pervasive activation of this “multiple-demand” (MD) network suggests a core function in supporting goal-oriented behavior. A similar network might therefore be predicted in nonhuman primates that readily perform similar tasks after training. However, an MD network in nonhuman primates has not been described. Single-cell recordings from macaque frontal and parietal cortex show some similar properties to human MD fMRI responses (e.g., adaptive coding of task-relevant information). Invasive recordings, however, come from limited prespecified locations, so they do not delineate a macaque homolog of the MD system and their positioning could benefit from knowledge of where MD foci lie. Challenges of scanning behaving animals mean that few macaque fMRI studies specifically contrast levels of cognitive demand, so we sought to identify a macaque counterpart to the human MD system using fMRI connectivity in 35 rhesus macaques. Putative macaque MD regions, mapped from frontoparietal MD regions defined in humans, were found to be functionally connected under anesthesia. To further refine these regions, an iterative process was used to maximize their connectivity cross-validated across animals. Finally, whole-brain connectivity analyses identified voxels that were robustly connected to MD regions, revealing seven clusters across frontoparietal and insular cortex comparable to human MD regions and one unexpected cluster in the lateral fissure. The proposed macaque MD regions can be used to guide future electrophysiological investigation of MD neural coding and in task-based fMRI to test predictions of similar functional properties to human MD cortex. SIGNIFICANCE STATEMENT In humans, a frontoparietal “multiple-demand” (MD) brain network is recruited during a wide range of cognitively demanding tasks. Because this suggests a fundamental function, one might expect a similar

  20. Rotating dipole and quadrupole field for a multiple cathode system

    SciTech Connect

    Chang, X.; Ben-Zvi, I.; Kewisch, J.; Litvinenko, V.; Meng, W.; Pikin, A.; Ptitsyn, V.; Rao, T.; Sheehy, B.; Skarita, J.; Wang, E.; Wu, Q.; Xin, T.

    2011-03-28

    A multiple cathode system has been designed to provide the high average current polarized electron bunches for the future electron-ion collider eRHIC [1]. One of the key research topics in this design is the technique to generate a combined dipole and quadrupole rotating field at high frequency (700 kHz). This type of field is necessary for combining bunches from different cathodes to the same axis with minimum emittance growth. Our simulations and the prototype test results to achieve this will be presented. The future eRHIC project, next upgrade of EHIC, will be the first electron-heavy ion collider in the world. For polarized-electron and polarized proton collisions, it requires a polarized electron source with high average current ({approx}50 mA), short bunch ({approx}3 mm), emittance of about 20 {micro}m and energy spread of {approx}1% at 10 MeV. The state-of-art polarized electron cathode can generate average current of about more than 1 mA, but much less than 50 mA. The current is limited by the quantum efficiency, lifetime, space charge and ultra-high vacuum requirement of the polarized cathode. A possible approach to achieve the 50 mA beam is to employ multiple cathodes, such as 20 cathodes, and combine the multiple bunched beams from cathodes to the same axis. We name it as 'Gatling gun' because its operations bear similarity to a multi-barrel Gatling gun. The electron spin direction is not affected by electric field but will follow to the direction of the magnetic bending. This requires that, to preserve the spin polarization from cathode, the fixed bending field after the solenoid and the rotating bending field in combiner must be either a pair of electric bendings or a pair of magnetic bendings. We choose the scheme with a pair of magnetic bendings because it is much easier than the scheme with a pair of electric bendings at our 200 keV electron energy level.

  1. Orbits of Four Young Triple-lined Multiple Systems

    NASA Astrophysics Data System (ADS)

    Tokovinin, Andrei

    2016-07-01

    Each of the nearby triple systems HIP 7601, 13498, 23824, and 113597 (HD 10800, 18198, 35877, 217379) consist of solar-type dwarfs with comparable masses, where all three components are resolved spectrally, while the outer pairs are resolved both visually and spectrally. These stars are relatively young (between 100 and 600 Myr) and chromospherically active (X-ray sources), although they rotate slowly. I determine the spectroscopic orbits of the inner subsystems (periods 19.4, 14.1, 5.6, 20.3 days) and the orbits of the outer systems (periods 1.75, 51, 27, 500 years, respectively). For HIP 7601 and 13498, the combined spectro-interferometric outer orbits produce direct measurement of the masses of all of the components, allowing for a comparison with stellar models. The 6708 Å lithium line is present and its strength is measured in each component individually by subtracting the contributions of the other components. The inner and outer orbits of HIP 7601 are nearly circular, likely co-planar, and have a modest period ratio of 1:33. This study contributes to the characterization of hierarchical multiplicity in the solar neighborhood and provides data for testing stellar evolutionary models and chronology.

  2. Emission current control system for multiple hollow cathode devices

    NASA Technical Reports Server (NTRS)

    Beattie, John R. (Inventor); Hancock, Donald J. (Inventor)

    1988-01-01

    An emission current control system for balancing the individual emission currents from an array of hollow cathodes has current sensors for determining the current drawn by each cathode from a power supply. Each current sensor has an output signal which has a magnitude proportional to the current. The current sensor output signals are averaged, the average value so obtained being applied to a respective controller for controlling the flow of an ion source material through each cathode. Also applied to each controller are the respective sensor output signals for each cathode and a common reference signal. The flow of source material through each hollow cathode is thereby made proportional to the current drawn by that cathode, the average current drawn by all of the cathodes, and the reference signal. Thus, the emission current of each cathode is controlled such that each is made substantially equal to the emission current of each of the other cathodes. When utilized as a component of a multiple hollow cathode ion propulsion motor, the emission current control system of the invention provides for balancing the thrust of the motor about the thrust axis and also for preventing premature failure of a hollow cathode source due to operation above a maximum rated emission current.

  3. Design of a Multiple Drug Delivery System Directed at Periodontitis

    PubMed Central

    Sundararaj, Sharath C.; Thomas, Mark V.; Peyyala, Rebecca; Dziubla, Thomas D.; Puleo, David A.

    2013-01-01

    Periodontal disease is highly prevalent, with 90% of the world population affected by either periodontitis or its preceding condition, gingivitis. These conditions are caused by bacterial biofilms on teeth, which stimulate a chronic inflammatory response that leads to loss of alveolar bone and, ultimately, the tooth. Current treatment methods for periodontitis address specific parts of the disease, with no individual treatment serving as a complete therapy. The present research sought to demonstrate development of a multiple drug delivery system for stepwise treatment of different stages of periodontal disease. More specifically, multilayered films were fabricated from an association polymer comprising cellulose acetate phthalate and Pluronic F-127 to achieve sequential release of drugs. The four types of drugs used were metronidazole, ketoprofen, doxycycline, and simvastatin to eliminate infection, inhibit inflammation, prevent tissue destruction, and aid bone regeneration, respectively. Different erosion times and adjustable sequential release profiles were achieved by modifying the number of layers or by inclusion of a slower-eroding polymer layer. Analysis of antibiotic and anti-inflammatory bioactivity showed that drugs released from the devices retained 100% bioactivity. The multilayered CAPP delivery system offers a versatile approach for releasing different drugs based on the pathogenesis of periodontitis and other conditions. PMID:23948165

  4. Clinicopathological study of 35 cases of multiple system atrophy.

    PubMed Central

    Wenning, G K; Ben-Shlomo, Y; Magalhães, M; Daniel, S E; Quinn, N P

    1995-01-01

    The clinical and pathological features of 35 cases with multiple system atrophy collected in the United Kingdom Parkinson's Disease Society Brain Bank (UKPDSBB) between 1985 and 1992 have been analysed. The median age of onset was 55 (range 33.3-75.8) years and median survival was 7.3 (range 2.1-11.5) years. Parkinsonism, usually asymmetric, occurred in all, and autonomic failure in all but one case. Cerebellar signs were noted in 34% and pyramidal features in 54% of the cases. Glial cytoplasmic inclusions were found in all cases with adequate fixation. Lewy bodies were detected in three cases. The substantia nigra was (usually severely) depleted of cells in all cases. With two exceptions the putamen was atrophic; the caudate and pallidum were less commonly and less severely affected. Overall nigrostriatal cell loss correlated with severity of disease at the time of death. The latest, but not the best, recorded levodopa response tended to be inversely related to the degree of putaminal degeneration. The olivopontocerebellar system was involved in 88% of the cases, the cerebellar vermis usually being more severely affected than the hemispheres. The presence of associated cerebellar pathology was, however, unrelated to the presence of cerebellar signs in life. PMID:7876845

  5. Tearing mode instability in a multiple current sheet system

    NASA Technical Reports Server (NTRS)

    Yan, M.; Otto, A.; Muzzell, D.; Lee, L. C.

    1994-01-01

    The tearing mode and magnetic reconnection are studied for multiple current sheet systems by two-dimensional magnetohydrodynamic (MHD) simulations. Both the linear and nonlinear evolution of this process are anaylsed for laminar perturbations. The results illustrate the existence of a linear regime with a symmetric and antisymmetric mode and agree with previous analytic results (Otto and Birk, 1992). The nonlinear evolution shows a number of interesting new features and may explain some properties in corresponding studies of turbulent reconnection. For wavelengths larger than twice the current sheet separation the evolution of antisymmetric modes leads to an entire reconfiguration of the magnetic field and converts a major portion of the magnetic energy into kinetic energy. Antisymmetric modes with smaller wavelengths and symmetric modes are found to saturate. The influence of the value of the resistivity on the reconnection rate decreases in the nonlinear evolution, and the ratio of current sheet separation to wavelength seems to be of major importance. A comparion of the dynamics of periodic current sheets with the evolution of only two current sheets indicates that some of the results for the periodic system also apply to the evolution of only two interacting current sheets. The results are discussed with respect to observations of large-scale plasma and magnetic field reconfigurations in the magnetosheath and near the Earth's bow shock.

  6. State recovery and lockstep execution restart in a system with multiprocessor pairing

    DOEpatents

    Gara, Alan; Gschwind, Michael K; Salapura, Valentina

    2014-01-21

    System, method and computer program product for a multiprocessing system to offer selective pairing of processor cores for increased processing reliability. A selective pairing facility is provided that selectively connects, i.e., pairs, multiple microprocessor or processor cores to provide one highly reliable thread (or thread group). Each paired microprocessor or processor cores that provide one highly reliable thread for high-reliability connect with a system components such as a memory "nest" (or memory hierarchy), an optional system controller, and optional interrupt controller, optional I/O or peripheral devices, etc. The memory nest is attached to a selective pairing facility via a switch or a bus. Each selectively paired processor core is includes a transactional execution facility, whereing the system is configured to enable processor rollback to a previous state and reinitialize lockstep execution in order to recover from an incorrect execution when an incorrect execution has been detected by the selective pairing facility.

  7. Microprocessors as a tool in determining correlation between sferics and tornado genesis: an update

    SciTech Connect

    Witte, D.R.

    1980-09-01

    Sferics - atmospheric electromagnetic radiation - can be directly correlated, it is believed, to the genesis of tornadoes and other severe weather. Sferics are generated by lightning and other atmospheric disturbances that are not yet entirely understood. The recording and analysis of the patterns in which sferics events occur, it is hoped, will lead to accurate real-time prediction of tornadoes and other severe weather. Collection of the tremendous amount of sferics data generated by one storm system becomes cumbersome when correlation between at least two stations is necessary for triangulation. Microprocessor-based computing systems have made the task of data collection and manipulation inexpensive and manageable. The original paper on this subject delivered at MAECON '78 dealt with hardware interfacing. Presented were hardware and software tradeoffs, as well as design and construction techniques to yield a cost effective system. This updated paper presents an overview of where the data comes from, how it is collected, and some current manipulation and interpretation techniques used.

  8. 15 CFR 744.17 - Restrictions on certain exports and reexports of general purpose microprocessors for “military...

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... reexports of general purpose microprocessors for âmilitary end-usesâ and to âmilitary end-users.â 744.17... microprocessors for “military end-uses” and to “military end-users.” (a) General prohibition. In addition to the... reexport commodities described in ECCN 3A991.a.1 on the CCL (“microprocessor microcircuits”,...

  9. A microprocessor-controlled fast-response speed regulator with dual mode current loop for DCM drives

    NASA Astrophysics Data System (ADS)

    Ohmae, T.; Matsuda, T.; Suzuki, T.; Azusawa, N.; Kamiyama, K.; Konishi, T.

    1980-06-01

    A new control method is described in which a microprocessor is used to regulate the speed of a dc motor driven by antiparallel-connected three-phase dual thyristor converters. A distinct feature of this speed regulating system is that speed response is improved by using a fast-response current controller for the internal loop. A fast-response current controller is obtained by employing a nonlinear compensation subloop and a proportional plus integral compensation subloop. The nonlinear compensation subloop is used to linearize the nonlinear load characteristics of the thyristor converter, which are encountered under discontinuous conduction states of current. The proportional plus integral compensation subloop reduces the deviation of detected current from the current reference. With these two current-control subloops a fast motor speed response is achieved under discontinuous as well as continuous conduction states; hence the steady-state accuracy of speed is improved. A speed regulator using a microprocessor was trial manufactured and tested with a 20-kW dc motor. It was found that an extremely fast controlled current response can be obtained even with a relatively long sampling period. Further, normal action was confirmed in four-quadrant operation.

  10. Designing an Electronic Patient Management System for Multiple Sclerosis: Building a Next Generation Multiple Sclerosis Documentation System

    PubMed Central

    Kern, Raimar; Haase, Rocco; Eisele, Judith Christina; Thomas, Katja

    2016-01-01

    Background Technologies like electronic health records or telemedicine devices support the rapid mediation of health information and clinical data independent of time and location between patients and their physicians as well as among health care professionals. Today, every part of the treatment process from diagnosis, treatment selection, and application to patient education and long-term care may be enhanced by a quality-assured implementation of health information technology (HIT) that also takes data security standards and concerns into account. In order to increase the level of effectively realized benefits of eHealth services, a user-driven needs assessment should ensure the inclusion of health care professional perspectives into the process of technology development as we did in the development process of the Multiple Sclerosis Documentation System 3D. After analyzing the use of information technology by patients suffering from multiple sclerosis, we focused on the needs of neurological health care professionals and their handling of health information technology. Objective Therefore, we researched the status quo of eHealth adoption in neurological practices and clinics as well as health care professional opinions about potential benefits and requirements of eHealth services in the field of multiple sclerosis. Methods We conducted a paper-and-pencil–based mail survey in 2013 by sending our questionnaire to 600 randomly chosen neurological practices in Germany. The questionnaire consisted of 24 items covering characteristics of participating neurological practices (4 items), the current use of network technology and the Internet in such neurological practices (5 items), physicians’ attitudes toward the general and MS-related usefulness of eHealth systems (8 items) and toward the clinical documentation via electronic health records (4 items), and physicians’ knowledge about the Multiple Sclerosis Documentation System (3 items). Results From 600 mailed

  11. Tidal Evolution of Multiple Planet Systems Around Brown Dwarfs

    NASA Astrophysics Data System (ADS)

    Bolmont, Emeline; Raymond, S. N.; Leconte, J.

    2012-10-01

    The tidal evolution of planets orbiting brown dwarfs (BDs) presents an interesting case study because BDs' terrestrial planet forming region is located extremely close-in. In fact, the habitable zones of BDs range from roughly 0.001 to 0.03 AU and for the lowest-mass BDs are located interior to the Roche limit. In contrast with stars, BDs spin up as they age. Thus, the corotation distance moves inward. We study the tidal evolution of planets around BDs using a standard tidal model and test the effect of numerous parameters such as the initial semi-major axis and eccentricity, the rotation period of the BD, the masses of both star and planet, and their tidal dissipation factor. We find that the most important parameter is the initial orbital distance with respect to the corotation distance. We find that all planets that form at or beyond the corotation distance and with initial eccentricities smaller than about 0.1 and are repelled from the star. Some planets initially interior to corotation can survive if their inward tidal evolution is slower than the BD's spin evolution, although most initially close-in planets fall onto the BD. Next we studied multiple planet systems with a N-body code altered to include tidal forces. We present a few interesting case studies for systems of planets orbiting BDs. In one example, a close-in planet pushes a more distant planet outward while locked in resonance. In another example, rapid outward tidal migration destabilizes a system of three planets. In another case, the combination of eccentricity forcing from an outer planet and dissipation within the inner planet drives the inner planet into the BD despite being exterior to the corotation radius. We thank the CNRS’s PNP program for funding.

  12. REGULATION OF MULTIPLE RENIN-ANGIOTENSIN SYSTEM GENES BY SRY

    PubMed Central

    Milsted, Amy; Underwood, Adam C.; Dunmire, Jeff; DelPuerto, Helen L.; Martins, Almir S.; Ely, Daniel L.; Turner, Monte E.

    2010-01-01

    We demonstrated that the Sry gene complex on the SHR Y chromosome is a candidate locus for hypertension that accounts for the SHR Y chromosome blood pressure effect. All rat strains examined to date share 6 Sry loci, and a seventh Sry locus (Sry3) appears to be unique to SHR males. Previously, we showed that Sry1 increased activity of the tyrosine hydroxylase promoter in transfected PC12 cells, and Sry1 delivered to adrenal gland of WKY rats increased blood pressure and sympathetic nervous system activity. The objective of this study was to determine whether renin-angiotensin system genes participate in Sry-mediated effects. Sry expression vectors were co-transfected into CHO cells with luciferase reporter constructs containing promoters of angiotensinogen (Agt −1430/+22), renin (Ren −1050/−1), ACE (ACE −1677/+21) and ACE2 (ACE2 −1091/+83). Sry1, Sry2 and Sry3 differentially up-regulated activity of the promoters of angiotensinogen, renin and ACE genes, and down-regulated ACE2 promoter activity. The largest effect was seen with Sry3, which increased activity of angiotensinogen promoter by 1.7 fold, renin promoter by 1.3 fold, ACE promoter by 2.6 fold, and decreased activity of ACE2 promoter by 0.5 fold. The effect of Sry1 on promoter activity was significantly less than Sry3. Sry2 activated promoters at a significantly lower level than Sry1. The result of either an additive effect of Sry regulation of multiple genes in the renin-angiotensin system or alterations in expression of a single gene could favor increased levels of Ang II and decreased levels of Ang-(1-7). These actions of Sry could result in increased blood pressure in males and contribute to gender differences in blood pressure. PMID:19809364

  13. Identification of limit cycles in multi-nonlinearity, multiple path systems

    NASA Technical Reports Server (NTRS)

    Mitchell, J. R.; Barron, O. L.

    1979-01-01

    A method of analysis which identifies limit cycles in autonomous systems with multiple nonlinearities and multiple forward paths is presented. The FORTRAN code for implementing the Harmonic Balance Algorithm is reported. The FORTRAN code is used to identify limit cycles in multiple path and nonlinearity systems while retaining the effects of several harmonic components.

  14. Data and results of a laboratory investigation of microprocessor upset caused by simulated lightning-induced analog transients

    NASA Technical Reports Server (NTRS)

    Belcastro, C. M.

    1984-01-01

    Advanced composite aircraft designs include fault-tolerant computer-based digital control systems with thigh reliability requirements for adverse as well as optimum operating environments. Since aircraft penetrate intense electromagnetic fields during thunderstorms, onboard computer systems maya be subjected to field-induced transient voltages and currents resulting in functional error modes which are collectively referred to as digital system upset. A methodology was developed for assessing the upset susceptibility of a computer system onboard an aircraft flying through a lightning environment. Upset error modes in a general-purpose microprocessor were studied via tests which involved the random input of analog transients which model lightning-induced signals onto interface lines of an 8080-based microcomputer from which upset error data were recorded. The application of Markov modeling to upset susceptibility estimation is discussed and a stochastic model development.

  15. 21 CFR 866.5660 - Multiple autoantibodies immunological test system.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... the autoantibodies (antibodies produced against the body's own tissues) in serum and other body fluids. Measurement of multiple autoantibodies aids in the diagnosis of autoimmune disorders (disease produced...

  16. Catastrophic Behavior of Multiple Coronal Flux Rope System

    NASA Astrophysics Data System (ADS)

    Ding, J. Y.; Hu, Y. Q.; Wang, J. X.

    2006-05-01

    A major solar active event called Bastille Day Event occurred in AR 9077 on July 14, 2000. Simultaneous occurrence of a filament eruption, a flare and a coronal mass ejection was observed in this event. Previous analyses of this event show that before the event, there existed an activation and eruption of a huge trans-equatorial filament, which might play a crucial role in triggering the Bastille Day event. This implies that independent flux systems are closely related to and affect each other, which has encouraged us to investigate the catastrophic behavior of a multiple coronal flux rope system with the use of a 2.5-D time-dependent MHD model. A force-free field that contains three separate coronal flux ropes is taken to be the initial state. Starting from this state, we increase either the annular or the axial flux of a certain flux rope to examine the catastrophic behavior of the system in two regimes, the ideal MHD regime and the resistive MHD regime. It is found that a catastrophe occurs if the flux exceeds a certain critical value, or the magnetic energy of the system exceeds a certain threshold: the rope of interest breaks away from the base and escapes to infinity, leaving a current sheet below. Moreover, the destiny of the remainder flux ropes relies on whether reconnection takes place across the current sheet. In the ideal MHD regime, i.e., in the absence of reconnection, these ropes remain to be attached to the base in equilibrium, whereas in the resistive MHD regime they abruptly erupt upward during reconnection and escape to infinity. Reconnection causes the field lines to close back to the base and thus changes the background field outside the attached flux ropes in such a way that the constraint on these ropes is substantially relaxed and the corresponding catastrophic energy threshold is reduced accordingly, leading to a catastrophic eruption of these ropes. Since magnetic reconnection is generally inevitable when a current sheet forms and develops

  17. Microprocessor-based near real-time bedside blood chemistry monitor.

    PubMed

    Wong, D K; Jordan, W S

    1992-01-01

    A microprocessor-based instrument which integrates the function of a volumetric infusion pump with a blood chemistry analyzer has been developed. Presently, the instrument is capable of measuring Na+, K+, Ca++ and pH within approximately 40 sec at a frequency of up to every 2 min. The system is set up as an intravenous (IV) infusion pump with the addition of an array of disposable sensors placed at the distal end of the IV set. An isotonic IV solution is used to keep the site patent while also serving as a calibrant for the sensors. The instrument first calibrates the sensors, then withdraws approximately 0.6 ml of blood to come in contact with the sensors. Within approximately 15 sec, it displays the results, flushes the blood back into the patient and resumes normal infusion. There is no blood loss to the patient and no need to handle blood. The system was first validated with known aqueous controls and then used on-line in a variety of animal studies where dynamic fluctuation of electrolytes and pH occurred. Excellent correlation was found with off-line samples tested on conventional STAT analyzers. Some preliminary patient data is also presented.

  18. Microprocessor controlled anodic stripping voltameter for trace metals analysis in tap water

    SciTech Connect

    Clem, R.G.; Park, F.W.; Kirsten, F.A.; Phillips, S.L.; Binnall, E.P.

    1981-04-01

    The construction and use of a portable, microprocessor controlled anodic stripping voltameter for on-site simultaneous metal analysis of copper, lead and cadmium in tap water is discussed. The instrumental system is comprised of a programmable controller which permits keying in analytical parameters such as sparge time and plating time; a rotating cell for efficient oxygen removal and amalgam formation; and, a magnetic tape which can be used for data storage. Analysis time can be as short as 10 to 15 minutes. The stripping analysis is based on a pre-measurement step during which the metals from a water sample are concentrated into a thin mercury film by deposition from an acetate solution of pH 4.5. The concentrated metals are then electrochemically dissolved from the film by application of a linearly increasing anodic potential. Typical peak-shaped curves are obtained. The heights of these curves are related to the concentration of metals in the water by calibration data. Results of tap water analysis showed 3 +- 1 ..mu..g/L lead, 22 +- 0.3 ..mu..g/L copper, and less than 0.2 ..mu..g/L cadmium for a Berkeley, California tap water, and 1 to 1000 ..mu..g/L Cu, 1 to 2 ..mu..g/L Pb for ten samples of Seattle, Washington tap water. Recommendations are given for a next generation instrument system.

  19. Skin vasodilator response to local heating in multiple system atrophy.

    PubMed

    Yamanaka, Yoshitaka; Asahina, Masato; Mathias, Christopher J; Akaogi, Yuichi; Koyama, Yu; Hattori, Takamichi

    2007-12-01

    Local heating of nonglabrous skin increases skin blood flow (SkBF) in two phases. The initial peak (P1) is mediated by a sensory-axon reflex and the plateau phase (P2) by local production of substances such as nitric oxide. We evaluated the SkBF response to local heating in 15 multiple system atrophy (MSA) patients with autonomic failure and 12 age-matched healthy controls. The mean ratio of SkBF at P1 to that at baseline (SkBF(P1)/SkBF(base) ratio) in MSA was significantly lower than that in controls (P < 0.01). The mean ratio of SkBF at P2 seemed to be slightly reduced in the MSA patients, compared with controls, although there was no significant difference. The P1 phase is thought to be mediated by a sensory-axon reflex modulated by sympathetic nerve activity. These findings are indicative of the skin sympathetic vasomotor dysfunction in MSA.

  20. Therapeutic advances in multiple system atrophy and progressive supranuclear palsy.

    PubMed

    Poewe, Werner; Mahlknecht, Philipp; Krismer, Florian

    2015-09-15

    Multiple system atrophy (MSA) and progressive supranuclear palsy (PSP) are relentlessly progressive neurodegenerative diseases leading to severe disability and ultimately death within less than 10 y. Despite increasing efforts in basic and clinical research, effective therapies for these atypical parkinsonian disorders are lacking. Although earlier small clinical studies in MSA and PSP mainly focused on symptomatic treatment, advances in the understanding of the molecular underpinnings of these diseases and in the search for biomarkers have paved the way for the first large and well-designed clinical trials aiming at disease modification. Targets of intervention in these trials have included α-synuclein inclusion pathology in the case of MSA and tau-related mechanisms in PSP. Since 2013, four large randomized, placebo-controlled, double-blind disease-modification trials have been completed and published, using rasagiline (MSA), rifampicin (MSA), tideglusib (PSP), or davunetide (PSP). All of these failed to demonstrate signal efficacy with regard to the primary outcome measures. In addition, two randomized, placebo-controlled, double-blind trials have studied the efficacy of droxidopa in the symptomatic treatment of neurogenic orthostatic hypotension, including patients with MSA, with positive results in one trial. This review summarizes the design and the outcomes of these and other smaller trials published since 2013 and attempts to highlight priority areas of future therapeutic research in MSA and PSP. © 2015 International Parkinson and Movement Disorder Society.

  1. Diffusion tensor imaging in the characterization of multiple system atrophy

    PubMed Central

    Rulseh, Aaron Michael; Keller, Jiri; Rusz, Jan; Syka, Michael; Brozova, Hana; Rusina, Robert; Havrankova, Petra; Zarubova, Katerina; Malikova, Hana; Jech, Robert; Vymazal, Josef

    2016-01-01

    Purpose Multiple system atrophy (MSA) is a rare neurodegenerative disease that remains poorly understood, and the diagnosis of MSA continues to be challenging. We endeavored to improve the diagnostic process and understanding of in vivo characteristics of MSA by diffusion tensor imaging (DTI). Materials and methods Twenty MSA subjects, ten parkinsonian dominant (MSA-P), ten cerebellar dominant (MSA-C), and 20 healthy volunteer subjects were recruited. Fractional anisotropy, mean diffusivity, radial diffusivity, and axial diffusivity maps were processed using tract-based spatial statistics. Diffusion data were additionally evaluated in the basal ganglia. A support vector machine was used to assess diagnostic utility, leave-one-out cross-validation in the evaluation of classification schemes, and receiver operating characteristic analyses to determine cutoff values. Results We detected widespread changes in the brain white matter of MSA subjects; however, no group-wise differences were found between MSA-C and MSA-P subgroups. Altered DTI metrics in the putamen and middle cerebellar peduncles were associated with a positive parkinsonian and cerebellar phenotype, respectively. Concerning clinical applicability, we achieved high classification performance on mean diffusivity data in the combined bilateral putamen and middle cerebellar peduncle (accuracy 90.3%±9%, sensitivity 86.5%±11%, and specificity 99.3%±4%). Conclusion DTI in the middle cerebellar peduncle and putamen may be used in the diagnosis of MSA with a high degree of accuracy. PMID:27616888

  2. Multiple sclerosis is not a disease of the immune system.

    PubMed

    Corthals, Angelique P

    2011-12-01

    Multiple sclerosis is a complex neurodegenerative disease, thought to arise through autoimmunity against antigens of the central nervous system. The autoimmunity hypothesis fails to explain why genetic and environmental risk factors linked to the disease in one population tend to be unimportant in other populations. Despite great advances in documenting the cell and molecular mechanisms underlying MS pathophysiology, the autoimmunity framework has also been unable to develop a comprehensive explanation of the etiology of the disease. I propose a new framework for understanding MS as a dysfunction of the metabolism of lipids. Specifically, the homeostasis of lipid metabolism collapses during acute-phase inflammatory response triggered by a pathogen, trauma, or stress, starting a feedback loop of increased oxidative stress, inflammatory response, and proliferation of cytoxic foam cells that cross the blood brain barrier and both catabolize myelin and prevent remyelination. Understanding MS as a chronic metabolic disorder illuminates four aspects of disease onset and progression: 1) its pathophysiology; 2) genetic susceptibility; 3) environmental and pathogen triggers; and 4) the skewed sex ratio of patients. It also suggests new avenues for treatment.

  3. Transmission of multiple system atrophy prions to transgenic mice

    PubMed Central

    Watts, Joel C.; Giles, Kurt; Oehler, Abby; Middleton, Lefkos; Dexter, David T.; Gentleman, Steve M.; DeArmond, Stephen J.; Prusiner, Stanley B.

    2013-01-01

    Prions are proteins that adopt alternative conformations, which become self-propagating. Increasing evidence argues that prions feature in the synucleinopathies that include Parkinson’s disease, Lewy body dementia, and multiple system atrophy (MSA). Although TgM83+/+ mice homozygous for a mutant A53T α-synuclein transgene begin developing CNS dysfunction spontaneously at ∼10 mo of age, uninoculated TgM83+/− mice (hemizygous for the transgene) remain healthy. To determine whether MSA brains contain α-synuclein prions, we inoculated the TgM83+/− mice with brain homogenates from two pathologically confirmed MSA cases. Inoculated TgM83+/− mice developed progressive signs of neurologic disease with an incubation period of ∼100 d, whereas the same mice inoculated with brain homogenates from spontaneously ill TgM83+/+ mice developed neurologic dysfunction in ∼210 d. Brains of MSA-inoculated mice exhibited prominent astrocytic gliosis and microglial activation as well as widespread deposits of phosphorylated α-synuclein that were proteinase K sensitive, detergent insoluble, and formic acid extractable. Our results provide compelling evidence that α-synuclein aggregates formed in the brains of MSA patients are transmissible and, as such, are prions. The MSA prion represents a unique human pathogen that is lethal upon transmission to Tg mice and as such, is reminiscent of the prion causing kuru, which was transmitted to chimpanzees nearly 5 decades ago. PMID:24218576

  4. Analysis of the prion protein gene in multiple system atrophy.

    PubMed

    Chelban, Viorica; Manole, Andreea; Pihlstrøm, Lasse; Schottlaender, Lucia; Efthymiou, Stephanie; OConnor, Emer; Meissner, Wassilios G; Holton, Janice L; Houlden, Henry

    2017-01-01

    Neurodegenerative diseases are a very diverse group of disorders but they share some common mechanisms such as abnormally misfolded proteins with prion-like propagation and aggregation. Creutzfeldt-Jakob disease (CJD) is the most prevalent prion disease in humans. In the sporadic form of CJD the only known risk factor is the codon 129 polymorphism. Recent reports suggested that α-synuclein in multiple system atrophy (MSA) has similar pathogenic mechanisms as the prion protein. Here we present 1 Italian family with MSA and prion disease. Also, cases of concurrent MSA and prion pathology in the same individual or family suggest the possibility of molecular interaction between prion protein and α-synuclein in the process of protein accumulation and neurodegeneration, warranting further investigations. We assessed the PRNP gene by whole-exome sequencing in 264 pathologically confirmed MSA cases and 462 healthy controls to determine whether the 2 diseases share similar risk factors. We then analyzed codon 129 polymorphism by Sanger sequencing and compared with previously published results in sporadic CJD. Homozygosity at codon 129 was present in 50% of pathologically confirmed MSA cases and in 58% of normal controls (odds ratio, 0.7 (95% confidence interval of 0.5-0.9)) compared with 88.2% in sporadic CJD. Our data show that the homozygous state of position 129 in the PRNP is not a risk factor for MSA. No other variants in the PRNP gene were associated with increased risk for MSA.

  5. Pathogenesis of laryngeal narrowing in patients with multiple system atrophy

    PubMed Central

    Isono, Shiroh; Shiba, Keisuke; Yamaguchi, Mika; Tanaka, Atsuko; Hattori, Takamichi; Konno, Akiyoshi; Nishino, Takashi

    2001-01-01

    We do not fully understand the pathogenesis of nocturnal laryngeal stridor in patients with multiple system atrophy (MSA). Recent studies suggest that inspiratory thyroarytenoid (TA) muscle activation has a role in the development of the stridor.The breathing pattern and firing timing of TA muscle activation were determined in ten MSA patients, anaesthetized with propofol and breathing through the laryngeal mask airway, while the behaviour of the laryngeal aperture was being observed endoscopically.Two distinct breathing patterns, i.e. no inspiratory flow limitation (no-IFL) and IFL, were identified during the measurements. During IFL, significant laryngeal narrowing was observed leading to an increase in laryngeal resistance and end-tidal carbon dioxide concentration. Development of IFL was significantly associated with the presence of phasic inspiratory activation of TA muscle. Application of continuous positive airway pressure suppressed the TA muscle activation.The results indicate that contraction of laryngeal adductors during inspiration narrows the larynx leading to development of inspiratory flow limitation accompanied by stridor in patients with MSA under general anaesthesia. PMID:11579172

  6. Animal modeling an oligodendrogliopathy--multiple system atrophy.

    PubMed

    Bleasel, Jonathan M; Halliday, Glenda M; Kim, Woojin Scott

    2016-02-09

    Multiple system atrophy (MSA) is a rare, yet rapidly-progressive neurodegenerative disease that presents clinically with autonomic failure in combination with parkinsonism or cerebellar ataxia. The definitive neuropathology differentiating MSA from Lewy body diseases is the presence of α-synuclein aggregates in oligodendrocytes (called glial cytoplasmic inclusion or GCI) rather than the fibrillar aggregates in neurons (called Lewy bodies). This makes the pathological pathway(s) in MSA unique in that oligodendrocytes are involved rather than predominantly neurons, as is most other neurodegenerative disorders. MSA is therefore regarded as an oligodendrogliopathy. The etiology of MSA is unknown. No definitive risk factors have been identified, although α-synuclein and other genes have been variably linked to MSA risk. Utilization of postmortem brain tissues has greatly advanced our understanding of GCI pathology and the subsequent neurodegeneration. However, extrapolating the early pathogenesis of MSA from such resource has been difficult and limiting. In recent years, cell and animal models developed for MSA have been instrumental in delineating unique MSA pathological pathways, as well as aiding in clinical phenotyping. The purpose of this review is to bring together and discuss various animal models that have been developed for MSA and how they have advanced our understanding of MSA pathogenesis, particularly the dynamics of α-synuclein aggregation. This review will also discuss how animal models have been used to explore potential therapeutic avenues for MSA, and future directions of MSA modeling.

  7. Urinary and erectile dysfunction in multiple system atrophy (MSA).

    PubMed

    Papatsoris, A G; Papapetropoulos, S; Singer, C; Deliveliotis, C

    2008-01-01

    Multiple system atrophy (MSA) is a neurodegenerative disease of undetermined etiology that occurs sporadically and manifests itself as a combination of parkinsonian, autonomic, cerebellar, and pyramidal signs. Despite the lack of effective therapies, some of the symptoms may be, at least temporarily, improved with adequate symptomatic therapies. Urinary and erectile dysfunction (ED) symptoms are prominent early features in male MSA patients. Lower urinary tract infections (UTIs) are a major cause of morbidity and mortality in this disorder. More than 50% of MSA patients suffer from recurrent lower UTIs and a significant number (approximately 25%) die of complications related to them. Urogenital symptoms in MSA are usually due to a complex mixture of central and peripheral nervous abnormalities, sometimes superimposed on previous local pathological conditions such as benign prostatic hyperplasia and perineal laxity. There have been instances were MSA-related urological symptoms were confused with symptoms of benign prostatic hyperplasia, leading to unnecessary urological surgery. In this review, we present the phenotypic range and therapeutic approaches for common storage and voiding urological symptoms and ED, in patients with MSA.

  8. Multiple dopant injection system for small rocket engines

    NASA Technical Reports Server (NTRS)

    Sakala, G. G.; Raines, N. G.

    1992-01-01

    The Diagnostics Test Facility (DTF) at NASA's Stennis Space Center (SSC) was designed and built to provide a standard rocket engine exhaust plume for use in the research and development of engine health monitoring instrumentation. A 1000 lb thrust class liquid oxygen (LOX)-gaseous hydrogen (GH2) fueled rocket engine is used as the subscale plume source to simulate the SSME during experimentation and instrument development. The ability of the DTF to provide efficient, and low cost test operations makes it uniquely suited for plume diagnostic experimentation. The most unique feature of the DTF is the Multiple Dopant Injection System (MDIS) that is used to seed the exhaust plume with the desired element or metal alloy. The dopant injection takes place at the fuel injector, yielding a very uniform and homogeneous distribution of the seeding material in the exhaust plume. The MDIS allows during a single test firing of the DTF, the seeding of the exhaust plume with up to three different dopants and also provides distilled water base lines between the dopants. A number of plume diagnostic-related experiments have already utilized the unique capabilities of the DTF.

  9. Stabilization of a nonlinear system by multiplicative noise

    NASA Astrophysics Data System (ADS)

    Billah, K. Y. R.; Shinozuka, M.

    1991-10-01

    The effect of multiplicative colored noise on the stabilization of a bistable system is studied numerically. In particular, numerical simulation of a much discussed theoretical study carried out by Graham and Schenzle [Phys. Rev. A 26, 1676 (1982)] is presented. To corroborate this study, analog simulation studies have been undertaken to date which concluded that there are substantial limitations of the theory. Subsequently, to commensurate with those numerical studies, a variant theoretical interpretation was also made. On the other hand, it is also discussed in the literature that the inherent presence of weak additive stochastic forces in analog-simulation measurements may have prevented the substantiation of the theory. With the present status thus being inconclusive, in this Rapid Communication digital-simulation results are presented that provide a variant perspective for the theoretical study. Importantly, the study also sheds new light on the old controversies: interpretation of Stratonovich and Ito calculi and adiabatic elimination. It is also pointed out that contrary to existing notion in the literature-that digital simulation is biased on the algorithm selected (Ito or Stratonovich)-one algorithm is capable of distinguishing the two interpretations. And this is possible due to the inclusion of inertia in the formulation by Graham and Schenzle.

  10. Chronic Traumatic Encephalopathy Pathology in Multiple System Atrophy.

    PubMed

    Koga, Shunsuke; Dickson, Dennis W; Bieniek, Kevin F

    2016-10-01

    Chronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disorder associated with repetitive traumatic brain injury. Multiple system atrophy (MSA) is a Parkinsonian disorder that can result in repetitive falls with associated head trauma. We hypothesized that patients with neurodegenerative disorders like MSA could develop CTE pathology. Therefore, we assessed CTE pathology in 139 MSA cases in our brain bank. Sections from convexity cerebral cortices were screened by immunohistochemistry with anti-phospho-tau antibody. For cases with suggestive CTE pathology, further sections of basal forebrain and hippocampus were immunostained. Consensus criteria were used to make the diagnosis of CTE and aging-related tau astrogliopathy (ARTAG) was differentiated from CTE pathology. Pertinent clinical information was derived from the available records and online searches. Of the 139 MSA cases, 8 (6%) had CTE pathology and 10 (8%) had ARTAG pathology. All 8 cases with CTE were male and 4 of them had a documented history of contact sports. The median age at death in MSA with CTE was younger than in MSA without CTE or MSA with ARTAG (60, 67, and 74 years, respectively; p = 0.002). Even without a known history of contact sports or head trauma, a small subset of cases with MSA had CTE pathology.

  11. Neural Computations in a Dynamical System with Multiple Time Scales

    PubMed Central

    Mi, Yuanyuan; Lin, Xiaohan; Wu, Si

    2016-01-01

    Neural systems display rich short-term dynamics at various levels, e.g., spike-frequency adaptation (SFA) at the single-neuron level, and short-term facilitation (STF) and depression (STD) at the synapse level. These dynamical features typically cover a broad range of time scales and exhibit large diversity in different brain regions. It remains unclear what is the computational benefit for the brain to have such variability in short-term dynamics. In this study, we propose that the brain can exploit such dynamical features to implement multiple seemingly contradictory computations in a single neural circuit. To demonstrate this idea, we use continuous attractor neural network (CANN) as a working model and include STF, SFA and STD with increasing time constants in its dynamics. Three computational tasks are considered, which are persistent activity, adaptation, and anticipative tracking. These tasks require conflicting neural mechanisms, and hence cannot be implemented by a single dynamical feature or any combination with similar time constants. However, with properly coordinated STF, SFA and STD, we show that the network is able to implement the three computational tasks concurrently. We hope this study will shed light on the understanding of how the brain orchestrates its rich dynamics at various levels to realize diverse cognitive functions. PMID:27679569

  12. Comparison of PSF maxima and minima of multiple annuli coded aperture (MACA) and complementary multiple annuli coded aperture (CMACA) systems

    NASA Astrophysics Data System (ADS)

    Ratnam, Challa; Lakshmana Rao, Vadlamudi; Lachaa Goud, Sivagouni

    2006-10-01

    In the present paper, and a series of papers to follow, the Fourier analytical properties of multiple annuli coded aperture (MACA) and complementary multiple annuli coded aperture (CMACA) systems are investigated. First, the transmission function for MACA and CMACA is derived using Fourier methods and, based on the Fresnel-Kirchoff diffraction theory, the formulae for the point spread function are formulated. The PSF maxima and minima are calculated for both the MACA and CMACA systems. The dependence of these properties on the number of zones is studied and reported in this paper.

  13. TRAIL/TRAIL Receptor System and Susceptibility to Multiple Sclerosis

    PubMed Central

    García-León, Juan Antonio; Pinto-Medel, María Jesús; Oliver-Martos, Begoña; Ortega-Pinazo, Jesús; Suardíaz, Margarita; García-Trujillo, Lucía; Guijarro-Castro, Cristina; Benito-León, Julián; Prat, Isidro; Varadé, Jezabel; Álvarez-Lafuente, Roberto; Urcelay, Elena

    2011-01-01

    The TNF-related apoptosis inducing ligand (TRAIL)/TRAIL receptor system participates in crucial steps in immune cell activation or differentiation. It is able to inhibit proliferation and activation of T cells and to induce apoptosis of neurons and oligodendrocytes, and seems to be implicated in autoimmune diseases. Thus, TRAIL and TRAIL receptor genes are potential candidates for involvement in susceptibility to multiple sclerosis (MS). To test whether single-nucleotide polymorphisms (SNPs) in the human genes encoding TRAIL, TRAILR-1, TRAILR-2, TRAILR-3 and TRAILR-4 are associated with MS susceptibility, we performed a candidate gene case-control study in the Spanish population. 59 SNPs in the TRAIL and TRAIL receptor genes were analysed in 628 MS patients and 660 controls, and validated in an additional cohort of 295 MS patients and 233 controls. Despite none of the SNPs withstood the highly conservative Bonferroni correction, three SNPs showing uncorrected p values<0.05 were successfully replicated: rs4894559 in TRAIL gene, p = 9.8×10−4, OR = 1.34; rs4872077, in TRAILR-1 gene, p = 0.005, OR = 1.72; and rs1001793 in TRAILR-2 gene, p = 0.012, OR = 0.84. The combination of the alleles G/T/A in these SNPs appears to be associated with a reduced risk of developing MS (p = 2.12×10−5, OR = 0.59). These results suggest that genes of the TRAIL/TRAIL receptor system exerts a genetic influence on MS. PMID:21814551

  14. A multiple-input-multiple-output visible light communication system based on VCSELs and spatial light modulators.

    PubMed

    Lu, Hai-Han; Lin, Ying-Pyng; Wu, Po-Yi; Chen, Chia-Yi; Chen, Min-Chou; Jhang, Tai-Wei

    2014-02-10

    A multiple-input-multiple-output (MIMO) visible light communication (VLC) system employing vertical cavity surface emitting laser (VCSEL) and spatial light modulators (SLMs) with 16-quadrature amplitude modulation (QAM)-orthogonal frequency-division multiplexing (OFDM) modulating signal is proposed and experimentally demonstrated. The transmission capacity of system is significantly increased by space-division demultiplexing scheme. With the assistance of low noise amplifier (LNA) and data comparator, good bit error rate (BER) performance, clear constellation map, and clear eye diagram are achieved for each optical channel. Such a MIMO VLC system would be attractive for providing services including data and telecommunication services. Our proposed system is suitably applicable to the lightwave communication system in wireless transmission.

  15. Kynurenines and Multiple Sclerosis: The Dialogue between the Immune System and the Central Nervous System.

    PubMed

    Rajda, Cecilia; Majláth, Zsófia; Pukoli, Dániel; Vécsei, László

    2015-08-06

    Multiple sclerosis is an inflammatory disease of the central nervous system, in which axonal transection takes place in parallel with acute inflammation to various, individual extents. The importance of the kynurenine pathway in the physiological functions and pathological processes of the nervous system has been extensively investigated, but it has additionally been implicated as having a regulatory function in the immune system. Alterations in the kynurenine pathway have been described in both preclinical and clinical investigations of multiple sclerosis. These observations led to the identification of potential therapeutic targets in multiple sclerosis, such as synthetic tryptophan analogs, endogenous tryptophan metabolites (e.g., cinnabarinic acid), structural analogs (laquinimod, teriflunomid, leflunomid and tranilast), indoleamine-2,3-dioxygenase inhibitors (1MT and berberine) and kynurenine-3-monooxygenase inhibitors (nicotinylalanine and Ro 61-8048). The kynurenine pathway is a promising novel target via which to influence the immune system and to achieve neuroprotection, and further research is therefore needed with the aim of developing novel drugs for the treatment of multiple sclerosis and other autoimmune diseases.

  16. Global identification of target recognition and cleavage by the Microprocessor in human ES cells.

    PubMed

    Seong, Youngmo; Lim, Do-Hwan; Kim, Augustine; Seo, Jae Hong; Lee, Young Sik; Song, Hoseok; Kwon, Young-Soo

    2014-11-10

    The Microprocessor plays an essential role in canonical miRNA biogenesis by facilitating cleavage of stem-loop structures in primary transcripts to yield pre-miRNAs. Although miRNA biogenesis has been extensively studied through biochemical and molecular genetic approaches, it has yet to be addressed to what extent the current miRNA biogenesis models hold true in intact cells. To address the issues of in vivo recognition and cleavage by the Microprocessor, we investigate RNAs that are associated with DGCR8 and Drosha by using immunoprecipitation coupled with next-generation sequencing. Here, we present global protein-RNA interactions with unprecedented sensitivity and specificity. Our data indicate that precursors of canonical miRNAs and miRNA-like hairpins are the major substrates of the Microprocessor. As a result of specific enrichment of nascent cleavage products, we are able to pinpoint the Microprocessor-mediated cleavage sites per se at single-nucleotide resolution. Unexpectedly, a 2-nt 3' overhang invariably exists at the ends of cleaved bases instead of nascent pre-miRNAs. Besides canonical miRNA precursors, we find that two novel miRNA-like structures embedded in mRNAs are cleaved to yield pre-miRNA-like hairpins, uncoupled from miRNA maturation. Our data provide a framework for in vivo Microprocessor-mediated cleavage and a foundation for experimental and computational studies on miRNA biogenesis in living cells.

  17. A real time, FEM based optimal control algorithm and its implementation using parallel processing hardware (transistors) in a microprocessor environment

    NASA Technical Reports Server (NTRS)

    Patten, William Neff

    1989-01-01

    There is an evident need to discover a means of establishing reliable, implementable controls for systems that are plagued by nonlinear and, or uncertain, model dynamics. The development of a generic controller design tool for tough-to-control systems is reported. The method utilizes a moving grid, time infinite element based solution of the necessary conditions that describe an optimal controller for a system. The technique produces a discrete feedback controller. Real time laboratory experiments are now being conducted to demonstrate the viability of the method. The algorithm that results is being implemented in a microprocessor environment. Critical computational tasks are accomplished using a low cost, on-board, multiprocessor (INMOS T800 Transputers) and parallel processing. Progress to date validates the methodology presented. Applications of the technique to the control of highly flexible robotic appendages are suggested.

  18. An updated histological classification system for multiple sclerosis lesions.

    PubMed

    Kuhlmann, Tanja; Ludwin, Samuel; Prat, Alexandre; Antel, Jack; Brück, Wolfgang; Lassmann, Hans

    2017-01-01

    Multiple sclerosis is a complex and heterogeneous, most likely autoimmune, demyelinating disease of the central nervous system (CNS). Although a number of histological classification systems for CNS lesions have been used by different groups in recent years, no uniform classification exists. In this paper, we propose a simple and unifying classification of MS lesions incorporating many elements of earlier histological systems that aims to provide guidelines for neuropathologists and researchers studying MS lesions to allow for better comparison of different studies performed with MS tissue, and to aid in understanding the pathogenesis of the disease. Based on the presence/absence and distribution of macrophages/microglia (inflammatory activity) and the presence/absence of ongoing demyelination (demyelinating activity), we suggest differentiating between active, mixed active/inactive, and inactive lesions with or without ongoing demyelination. Active lesions are characterized by macrophages/microglia throughout the lesion area, whereas mixed active/inactive lesions have a hypocellular lesion center with macrophages/microglia limited to the lesion border. Inactive lesions are almost completely lacking macrophages/microglia. Active and mixed active/inactive lesions can be further subdivided into lesions with ongoing myelin destruction (demyelinating lesions) and lesions in which the destruction of myelin has ceased, but macrophages are still present (post-demyelinating lesions). This distinction is based on the presence or absence of myelin degradation products within the cytoplasm of macrophages/microglia. For this classification of MS lesions, identification of myelin with histological stains [such as luxol fast blue-PAS] or by immunohistochemistry using antibodies against myelin basic-protein (MBP) or proteolipid-protein (PLP), as well as, detection of macrophages/microglia by, e.g., anti-CD68 is sufficient. Active and demyelinating lesions may be further

  19. Multiple-Input Multiple-Output (MIMO) Linear Systems Extreme Inputs/Outputs

    DOE PAGES

    Smallwood, David O.

    2007-01-01

    A linear structure is excited at multiple points with a stationary normal random process. The response of the structure is measured at multiple outputs. If the autospectral densities of the inputs are specified, the phase relationships between the inputs are derived that will minimize or maximize the trace of the autospectral density matrix of the outputs. If the autospectral densities of the outputs are specified, the phase relationships between the outputs that will minimize or maximize the trace of the input autospectral density matrix are derived. It is shown that other phase relationships and ordinary coherence less than one willmore » result in a trace intermediate between these extremes. Least favorable response and some classes of critical response are special cases of the development. It is shown that the derivation for stationary random waveforms can also be applied to nonstationary random, transients, and deterministic waveforms.« less

  20. Extreme inputs/outputs for multiple input multiple output linear systems.

    SciTech Connect

    Smallwood, David Ora

    2005-09-01

    A linear structure is excited at multiple points with a stationary normal random process. The response of the structure is measured at multiple outputs. If the auto spectral densities of the inputs are specified, the phase relationships between the inputs are derived that will minimize or maximize the trace of the auto spectral density matrix of the outputs. If the autospectral densities of the outputs are specified, the phase relationships between the outputs that will minimize or maximize the trace of the input auto spectral density matrix are derived. It is shown that other phase relationships and ordinary coherence less than one will result in a trace intermediate between these extremes. Least favorable response and some classes of critical response are special cases of the development. It is shown that the derivation for stationary random waveforms can also be applied to nonstationary random, transients, and deterministic waveforms.

  1. Personal Cabin Pressure Monitor and Warning System

    NASA Technical Reports Server (NTRS)

    Zysko, Jan A. (Inventor)

    2002-01-01

    A cabin pressure altitude monitor and warning system provides a warning when a detected cabin pressure altitude has reached a predetermined level. The system is preferably embodied in a portable, pager-sized device that can be carried or worn by an individual. A microprocessor calculates the pressure altitude from signals generated by a calibrated pressure transducer and a temperature sensor that compensates for temperature variations in the signals generated by the pressure transducer. The microprocessor is programmed to generate a warning or alarm if a cabin pressure altitude exceeding a predetermined threshold is detected. Preferably, the microprocessor generates two different types of warning or alarm outputs, a first early warning or alert when a first pressure altitude is exceeded. and a second more serious alarm condition when either a second. higher pressure altitude is exceeded, or when the first pressure altitude has been exceeded for a predetermined period of time. Multiple types of alarm condition indicators are preferably provided, including visual, audible and tactile. The system is also preferably designed to detect gas concentrations and other ambient conditions, and thus incorporates other sensors, such as oxygen, relative humidity, carbon dioxide, carbon monoxide and ammonia sensors, to provide a more complete characterization and monitoring of the local environment.

  2. Microprocessor-controlled optical stimulating device to improve the gait of patients with Parkinson's disease.

    PubMed

    Ferrarin, M; Brambilla, M; Garavello, L; Di Candia, A; Pedotti, A; Rabuffetti, M

    2004-05-01

    Different types of visual cue for subjects with Parkinson's disease (PD) produced an improvement in gait and helped some of them prevent or overcome freezing episodes. The paper describes a portable gait-enabling device (optical stimulating glasses (OSGs) that provides, in the peripheral field of view, different types of continuous optic flow (backward or forward) and intermittent stimuli synchronised with external events. The OSGs are a programmable, stand-alone, augmented reality system that can be interfaced with a PC for program set-up. It consists of a pair of non-corrective glasses, equipped with two matrixes of 70 micro light emitting diodes, one on each side, controlled by a microprocessor. Two foot-switches are used to synchronise optical stimulation with specific gait events. A pilot study was carried out on three PD patients and three controls, with different types of optic flow during walking along a fixed path. The continuous optic flow in the forward direction produced an increase in gait velocity in the PD patients (up to + 11% in average), whereas the controls had small variations. The stimulation synchronised with the swing phase, associated with an attentional strategy, produced a remarkable increase in stride length for all subjects. After prolonged testing, the device has shown good applicability and technical functionality, it is easily wearable and transportable, and it does not interfere with gait.

  3. Microprocessors for auditing the surveillance activity of the Infection Control Nurse.

    PubMed

    Desai, N; Honeywell, K; Casewell, M W

    1991-06-01

    An important part of the Infection Control Nurse's activity in the UK is the laboratory-based surveillance of patients with infections that are known to be transmissible, i.e. of 'alert' organisms. We have replaced a manual 'T-card' system in which relevant patient information, microbiology and nursing notes are held on all patients yielding 'alert' organisms. The programme is menu driven, requires minimal coding and runs on a microprocessor with a hard disc. The programme enables surveillance patient information to be entered, edited, archived and recorded. Instant retrieval on screen or hard copy includes summarized or full displays of all patients on all wards, sorted by wards, organism, date or risk category. Archived data may be retrieved within minutes and this avoids having to interrogate the whole laboratory database overnight. To illustrate an additional use of the data stored, we analysed the surveillance activities of the Control of Infection Nurse for one year. Of 203 laboratory diagnoses requiring patient surveillance, 30% were viral infections, of which more than two-thirds were caused by hepatitis B virus; of the 142 bacterial isolates, 27% were multiply antibiotic-resistant Enterobacteriaceae, 25% Pseudomonas spp, 12% Salmonella spp., 9% methicillin-resistant Staphylococcus aureus (MRSA), 7% Group A streptococci and 8% meningococci. These isolates resulted in only four outbreaks involving nine patients or staff. This information has proved useful for auditing the nurse's activity and provides evidence for the cost-effectiveness of infection control.

  4. Plasticity of the motor system in multiple sclerosis.

    PubMed

    Zeller, D; Classen, J

    2014-12-26

    Multiple sclerosis (MS) is a chronic neurological disease characterized by inflammation and degeneration within the CNS. Over the course of the disease, most MS patients successively accumulate inflammatory lesions, axonal damage, and a rather diffuse CNS pathology, along with an increasing degree of disability. Pharmacological treatment options which are currently approved for MS aim at limiting inflammation and decreasing the relapse rate, or at simply relieving symptoms. Established disease-modifying and immunosuppressive treatments are unable to prevent the accumulation of pathology in most patients over long-term. Therefore, therapies promoting the innate ability of the CNS to compensate for dysfunction resulting from brain injury might be highly beneficial in MS. As a precondition, however, development of such strategies requires well-grounded knowledge about the extent to which central plasticity is intact and accessible in MS patients, and whether it is functionally relevant at all. This review will focus on plasticity of the motor system in patients with MS. A number of functional imaging studies have assessed patterns of brain activation during simple motor tasks in MS patients and their relationship with CNS damage and motor function. Deeper insights about causal and functional relationships were gained by neurophysiological techniques, predominantly by transcranial magnetic stimulation. In addition, and probably closest to rehabilitative approaches, practice-induced plasticity has been probed in a few studies. Altogether, there is growing evidence for a preservation of rapid-onset motor plasticity and for functionally relevant chronic reorganization processes, which might be limited by high CNS injury in advanced stages of the disease. Clinical implications of these findings with regard to the development and optimization of rehabilitative treatments in MS are discussed, as well as open questions which need to be addressed by future studies.

  5. Differential involvement of hypothalamic vasopressin neurons in multiple system atrophy.

    PubMed

    Benarroch, Eduardo E; Schmeichel, Ann M; Sandroni, Paola; Low, Phillip A; Parisi, Joseph E

    2006-10-01

    We sought to determine whether there is differential involvement of different groups of hypothalamic arginine-vasopressin (AVP) synthesizing neurons in multiple system atrophy (MSA). Hypothalamus was obtained from five subjects with clinical diagnosis of MSA confirmed neuropathologically and five age-matched controls. Sections were immunostained for AVP, and cells with visible nuclei were counted in the posterior portion of the paraventricular nucleus (PVNp), supraoptic nucleus (SON), magnocellular PVN and suprachiasmatic nucleus (SCN). Sections of the hypothalamus and medulla were also immunostained for tyrosine hydroxylase (TH). There was a significant loss of AVP neurons in the PVNp in MSA compared with controls (17 +/- 3 versus 59 +/- 10 cells/section, P < 0.01). There was preservation of AVP- and TH-immunoreactive neurons in the SON and magnocellular PVN in all MSA cases. In contrast, there was marked depletion of TH-immunoreactive fibres innervating these magnocellular AVP neurons, coincident with a loss of neurons in the A1 area (6 +/- 1 versus 13 +/- 1 cells/section, P < 0.01). There was loss of AVP neurons in the SCN in MSA compared with control cases (14 +/- 3 versus 71 +/- 16 cells/section, P < 0.02). Our results indicate that, in MSA, loss of AVP neurons in the PVNp may contribute to sympathetic failure, whereas loss of catecholaminergic input from the brainstem to the magnocellular AVP neurons may contribute to impaired AVP secretion in response to orthostatic stress. Loss of AVP neurons in the SCN may contribute to impaired circadian regulation of endocrine and autonomic functions.

  6. Comparison of Different Symptom Assessment Scales for Multiple System Atrophy.

    PubMed

    Matsushima, Masaaki; Yabe, Ichiro; Oba, Koji; Sakushima, Ken; Mito, Yasunori; Takei, Asako; Houzen, Hideki; Tsuzaka, Kazufumi; Yoshida, Kazuto; Maruo, Yasunori; Sasaki, Hidenao

    2016-04-01

    To identify the most sensitive scale for use in clinical trials on multiple system atrophy (MSA), a short and sensitive scale is needed for MSA clinical trials. Potential candidates are the Unified MSA Rating Scale (UMSARS), Scale for the Assessment and Rating of Ataxia (SARA), Berg Balance Scale (BBS), MSA Health-Related Quality of Life scale (MSA-QoL), and Scales for Outcomes in Parkinson's Disease-Autonomic questionnaire (SCOPA-AUT). We enrolled patients with MSA from eight hospitals in Hokkaido, Japan. Board-certified neurologists assessed each patient at 6-month intervals and scored them on the UMSARS, SARA, BBS, MSA-QoL, and SCOPA-AUT. Score changes were evaluated using the standardized response mean (SRM). The correlation between disease duration and each score was examined. The first evaluation was conducted on 85 patients (60 patients with MSA cerebellar ataxia dominant subtype [MSA-C] and 25 patients with MSA Parkinsonism-dominant subtype [MSA-P]). Sixty-nine patients were examined after 6 months and 63 patients after 12 months. The UMSARS Part 4 had the largest SRM after 6 months and the SARA after 12 months. SRMs for MSA-P, the shorter duration group, and the early-onset group were larger than were those for MSA-C, the longer duration group, and the late-onset group. SRMs for items regarding skilled hand activities, walking, and standing were relatively large. Our study indicates that the UMSARS (parts 2 and 4), SARA, and BBS are sensitive scales for evaluating MSA progression over 12 months. Items with large SRMs effectively evaluated short-term changes.

  7. Health-related quality of life in multiple system atrophy.

    PubMed

    Schrag, Anette; Geser, Felix; Stampfer-Kountchev, Michaela; Seppi, Klaus; Sawires, Martin; Köllensperger, Martin; Scherfler, Christoph; Quinn, Niall; Pellecchia, Maria T; Barone, Paolo; Del Sorbo, Francesca; Albanese, Alberto; Ostergaard, Karen; Dupont, Erik; Cardozo, Adriana; Tolosa, Eduardo; Nilsson, Christer F; Widner, Håkan; Lindvall, Olle; Giladi, Nir; Gurevich, Tanya; Daniels, Christine; Deuschl, Günther; Coelho, Miguel; Sampaio, Cristina; Abele, Michael; Klockgether, Thomas; Schimke, Nicole; Eggert, Karla M; Oertel, Wolfgang; Djaldetti, Ruth; Colosimo, Carlo; Meco, Giuseppe; Poewe, Werner; Wenning, Gregor K

    2006-06-01

    Although multiple system atrophy (MSA) is a neurodegenerative disorder leading to progressive disability and decreased life expectancy, little is known about patients' own evaluation of their illness and factors associated with poor health-related quality of life (Hr-QoL). We, therefore, assessed Hr-QoL and its determinants in MSA. The following scales were applied to 115 patients in the European MSA-Study Group (EMSA-SG) Natural History Study: Medical Outcome Study Short Form (SF-36), EQ-5D, Beck Depression Inventory (BDI), Mini-Mental state examination (MMSE), Unified MSA Rating Scale (UMSARS), Hoehn & Yahr (H&Y) Parkinson's disease staging scale, Composite Autonomic Symptom Scale (COMPASS), and Parkinson's Disease Sleep Scale (PDSS). Forty-six percent of patients had moderate to severe depression (BDI > or = 17); Hr-QoL scores on the SF-36 and EQ-5D were significantly impaired. Pain, the only domain with similar scores in MSA and published PD patients, was reported more frequently in patients with MSA-P (predominantly parkinsonian motor subtype) than MSA-C (predominantly cerebellar motor subtype; 76% vs. 50%; P = 0.005). Hr-QoL scores correlated most strongly with UMSARS motor, COMPASS, and BDI scores but not with MMSE scores, age at onset, or disease duration. The COMPASS and UMSARS activities of daily living scores were moderate-to-strong predictors for the SF-36 physical summary score and the BDI and UMSARS motor scores for the SF-36 mental summary score. This report is the first study to show that Hr-QoL is significantly impaired in MSA. Although not all possible factors related to impaired Hr-QoL in MSA could be assessed, autonomic dysfunction, motor impairment, and depression were most closely associated with poor Hr-QoL, and therapeutic management, therefore, should concentrate upon these aspects of the disease.

  8. Acoustic Characteristics of Stridor in Multiple System Atrophy

    PubMed Central

    Lee, Jee Young; Joo, Eun Yeon; Nam, Hyunwoo

    2016-01-01

    Nocturnal stridor is a breathing disorder prevalent in patients with multiple system atrophy (MSA). An improved understanding of this breathing disorder is essential since nocturnal stridor carries a poor prognosis (an increased risk of sudden death). In this study, we aimed to classify types of stridor by sound analysis and to reveal their clinical significance. Patients who met the criteria for probable MSA and had undergone polysomnography (PSG) were recruited. Patients were then assessed clinically with sleep questionnaires, including the Pittsburgh Sleep Quality Index, and the Hoehn and Yahr scale. Nocturnal stridor and snoring were analyzed with the Multi-Dimensional Voice Program. Nocturnal stridor was recorded in 22 patients and snoring in 18 patients using the PSG. Waveforms of stridors were classified into rhythmic or semirhythmic after analysis of the oscillogram. Formants and harmonics were observed in both types of stridor, but not in snoring. Of the 22 patients diagnosed with stridor during the present study, fifteen have subsequently died, with the time to death after the PSG study being 1.9 ± 1.4 years (range 0.8 to 5.0 years). The rhythmic waveform group presented higher scores on the Hoehn and Yahr scale and the survival outcome of this group was lower compared to the semirhythmic waveform group (p = 0.030, p = 0.014). In the Kaplan Meier’s survival curve, the outcome of patients with rhythmic waveform was significantly less favorable than the outcome of patients with semirhythmic waveform (log-rank test, p < 0.001). Stridor in MSA can be classified into rhythmic and semirhythmic types and the rhythmic component signifies a poorer outcome. PMID:27093692

  9. Exploring lipids with nonlinear optical microscopy in multiple biological systems

    NASA Astrophysics Data System (ADS)

    Alfonso-Garcia, Alba

    Lipids are crucial biomolecules for the well being of humans. Altered lipid metabolism may give rise to a variety of diseases that affect organs from the cardiovascular to the central nervous system. A deeper understanding of lipid metabolic processes would spur medical research towards developing precise diagnostic tools, treatment methods, and preventive strategies for reducing the impact of lipid diseases. Lipid visualization remains a complex task because of the perturbative effect exerted by traditional biochemical assays and most fluorescence markers. Coherent Raman scattering (CRS) microscopy enables interrogation of biological samples with minimum disturbance, and is particularly well suited for label-free visualization of lipids, providing chemical specificity without compromising on spatial resolution. Hyperspectral imaging yields large datasets that benefit from tailored multivariate analysis. In this thesis, CRS microscopy was combined with Raman spectroscopy and other label-free nonlinear optical techniques to analyze lipid metabolism in multiple biological systems. We used nonlinear Raman techniques to characterize Meibum secretions in the progression of dry eye disease, where the lipid and protein contributions change in ratio and phase segregation. We employed similar tools to examine lipid droplets in mice livers aboard a spaceflight mission, which lose their retinol content contributing to the onset of nonalcoholic fatty-liver disease. We also focused on atherosclerosis, a disease that revolves around lipid-rich plaques in arterial walls. We examined the lipid content of macrophages, whose variable phenotype gives rise to contrasting healing and inflammatory activities. We also proposed new label-free markers, based on lifetime imaging, for macrophage phenotype, and to detect products of lipid oxidation. Cholesterol was also detected in hepatitis C virus infected cells, and in specific strains of age-related macular degeneration diseased cells by

  10. Scheduler for multiprocessor system switch with selective pairing

    DOEpatents

    Gara, Alan; Gschwind, Michael Karl; Salapura, Valentina

    2015-01-06

    System, method and computer program product for scheduling threads in a multiprocessing system with selective pairing of processor cores for increased processing reliability. A selective pairing facility is provided that selectively connects, i.e., pairs, multiple microprocessor or processor cores to provide one highly reliable thread (or thread group). The method configures the selective pairing facility to use checking provide one highly reliable thread for high-reliability and allocate threads to corresponding processor cores indicating need for hardware checking. The method configures the selective pairing facility to provide multiple independent cores and allocate threads to corresponding processor cores indicating inherent resilience.

  11. A heterotrimer model of the complete Microprocessor complex revealed by single-molecule subunit counting.

    PubMed

    Herbert, Kristina M; Sarkar, Susanta K; Mills, Maria; Delgado De la Herran, Hilda C; Neuman, Keir C; Steitz, Joan A

    2016-02-01

    During microRNA (miRNA) biogenesis, the Microprocessor complex (MC), composed minimally of Drosha, an RNaseIII enzyme, and DGCR8, a double-stranded RNA-binding protein, cleaves the primary-miRNA (pri-miRNA) to release the pre-miRNA stem-loop structure. Size-exclusion chromatography of the MC, isolated from mammalian cells, suggested multiple copies of one or both proteins in the complex. However, the exact stoichiometry was unknown. Initial experiments suggested that DGCR8 bound pri-miRNA substrates specifically, and given that Drosha could not be bound or cross-linked to RNA, a sequential model for binding was established in which DGCR8 bound first and recruited Drosha. Therefore, many laboratories have studied DGCR8 binding to RNA in the absence of Drosha and have shown that deletion constructs of DGCR8 can multimerize in the presence of RNA. More recently, it was demonstrated that Drosha can bind pri-miRNA substrates in the absence of DGCR8, casting doubt on the sequential model of binding. In the same study, using a single-molecule photobleaching assay, fluorescent protein-tagged deletion constructs of DGCR8 and Drosha assembled into a heterotrimeric complex on RNA, comprising two DGCR8 molecules and one Drosha molecule. To determine the stoichiometry of Drosha and DGCR8 within the MC in the absence of added RNA, we also used a single-molecule photobleaching assay and confirmed the heterotrimeric model of the human MC. We demonstrate that a heterotrimeric complex is likely preformed in the absence of RNA and exists even when full-length proteins are expressed and purified from human cells, and when hAGT-derived tags are used rather than fluorescent proteins.

  12. COED Transactions, Vol. XI, No. 12, December 1979. Some Alternate Applications of Microprocessor Trainers in Support of Undergraduate Laboratories.

    ERIC Educational Resources Information Center

    Mitchell, Eugene E., Ed.

    Ways are described for the use of a microprocessor trainer in undergraduate laboratories. Listed are microcomputer applications that have been used as demonstrations and which provide signals for other experiments which are not related to microprocessors. Information and figures are provided for methods to do the following: direct generation of…

  13. Frequency Dependence of Single-event Upset in Advanced Commerical PowerPC Microprocessors

    NASA Technical Reports Server (NTRS)

    Irom, Frokh; Farmanesh, Farhad F.; Swift, Gary M.; Johnston, Allen H.

    2004-01-01

    This paper examines single-event upsets in advanced commercial SOI microprocessors in a dynamic mode, studying SEU sensitivity of General Purpose Registers (GPRs) with clock frequency. Results are presented for SOI processors with feature sizes of 0.18 microns and two different core voltages. Single-event upset from heavy ions is measured for advanced commercial microprocessors in a dynamic mode with clock frequency up to 1GHz. Frequency and core voltage dependence of single-event upsets in registers is discussed.

  14. Single-event upset in highly scaled commercial silicon-on-insulator PowerPc microprocessors

    NASA Technical Reports Server (NTRS)

    Irom, Farokh; Farmanesh, Farhad H.

    2004-01-01

    Single event upset effects from heavy ions are measured for Motorola and IBM silicon-on-insulator (SOI) microprocessors with different feature sizes, and core voltages. The results are compared with results for similar devices with build substrates. The cross sections of the SOI processors are lower than their bulk counterparts, but the threshold is about the same, even though the charge collections depth is more than an order of magnitude smaller in the SOI devices. The scaling of the cross section with reduction of feature size and core voltage dependence for SOI microprocessors discussed.

  15. Distributed Microprocessor Automation Network for Synthesizing Radiotracers Used in Positron Emission Tomography [PET

    DOE R&D Accomplishments Database

    Russell, J. A. G.; Alexoff, D. L.; Wolf, A. P.

    1984-09-01

    This presentation describes an evolving distributed microprocessor network for automating the routine production synthesis of radiotracers used in Positron Emission Tomography. We first present a brief overview of the PET method for measuring biological function, and then outline the general procedure for producing a radiotracer. The paper identifies several reasons for our automating the syntheses of these compounds. There is a description of the distributed microprocessor network architecture chosen and the rationale for that choice. Finally, we speculate about how this network may be exploited to extend the power of the PET method from the large university or National Laboratory to the biomedical research and clinical community at large. (DT)

  16. Optical Power Transfer System for Powering a Remote Mobility System for Multiple Missions

    NASA Technical Reports Server (NTRS)

    Stone, William C. (Inventor); Hogan, Bartholomew P. (Inventor)

    2016-01-01

    An optical power transfer system for powering a remote mobility system for multiple missions comprising a high power source and a chilling station connected to a laser source. The laser source transmits a high optical energy to a beam switch assembly via an optical fiber. The beam switch assembly is optically connected to actively cooled fiber spoolers. Docking stations are adapted for securing the fiber spoolers until alternatively ready for use by a remote mobility system. The remote mobility system is optically connected to the fiber spoolers and has a receiving port adapted for securing the fiber spoolers thereon. The fiber spooler transmits the optical energy to a power conversion system which converts the optical energy received to another usable form of energy. More than one power source may be used where the remote mobility system transfers from one source to another while maintaining an operational radius to each source.

  17. Annual elk calf survival in a multiple carnivore system

    USGS Publications Warehouse

    Eacker, Daniel R.; Hebblewhite, Mark; Proffitt, Kelly M.; Jimenez, Benjamin S.; Mitchell, Michael S.; Robinson, Hugh S.

    2016-01-01

    The realized effect of multiple carnivores on juvenile ungulate recruitment may depend on the carnivore assemblage as well as compensation from forage and winter weather severity, which may mediate juvenile vulnerability to predation in ungulates. We used a time-to-event approach to test for the effects of risk factors on annual elk (Cervus canadensis) calf survival and to estimate cause-specific mortality rates for 2 elk populations in adjacent study areas in the southern Bitterroot Valley, Montana, USA, during 2011–2014. We captured and radio-tagged 286 elk calves: 226 neonates, and 60 6-month-old calves. Summer survival probability was less variable than winter (P = 0.12) and averaged 0.55 (95% CI = 0.47–0.63), whereas winter survival varied more than summer and significantly across study years (P = 0.003) and averaged 0.73 (95% CI = 0.64–0.81). During summer, elk calf survival increased with biomass of preferred forage biomass, and was slightly lower following winters with high precipitation; exposure to mountain lion (Puma concolor) predation risk was unimportant. In contrast, during winter, we found that exposure to mountain lion predation risk influenced survival, with a weak negative effect of winter precipitation. We found no evidence that forage availability or winter weather severity mediated vulnerability to mountain lion predation risk in summer or winter (e.g., an interaction), indicating that the effect of mountain lion predation was constant regardless of spatial variation in forage or weather. Mountain lions dominated known causes of elk calf mortality in summer and winter, with estimated cause-specific mortality rates of 0.14 (95% CI = 0.09–0.20) and 0.12 (95% CI = 0.07–0.18), respectively. The effect of carnivores on juvenile ungulate recruitment varies across ecological systems depending on relative carnivore densities. Mountain lions may be the most important carnivore for ungulates, especially where grizzly

  18. Theory and investigation of acoustic multiple-input multiple-output systems based on spherical arrays in a room.

    PubMed

    Morgenstern, Hai; Rafaely, Boaz; Zotter, Franz

    2015-11-01

    Spatial attributes of room acoustics have been widely studied using microphone and loudspeaker arrays. However, systems that combine both arrays, referred to as multiple-input multiple-output (MIMO) systems, have only been studied to a limited degree in this context. These systems can potentially provide a powerful tool for room acoustics analysis due to the ability to simultaneously control both arrays. This paper offers a theoretical framework for the spatial analysis of enclosed sound fields using a MIMO system comprising spherical loudspeaker and microphone arrays. A system transfer function is formulated in matrix form for free-field conditions, and its properties are studied using tools from linear algebra. The system is shown to have unit-rank, regardless of the array types, and its singular vectors are related to the directions of arrival and radiation at the microphone and loudspeaker arrays, respectively. The formulation is then generalized to apply to rooms, using an image source method. In this case, the rank of the system is related to the number of significant reflections. The paper ends with simulation studies, which support the developed theory, and with an extensive reflection analysis of a room impulse response, using the platform of a MIMO system.

  19. Multiple Source DF (Direction Finding) Signal Processing: An Experimental System,

    DTIC Science & Technology

    The MUltiple SIgnal Characterization ( MUSIC ) algorithm is an implementation of the Signal Subspace Approach to provide parameter estimates of...the signal subspace (obtained from the received data) and the array manifold (obtained via array calibration). The MUSIC algorithm has been

  20. Steady-State Multiplicity Features of Chemically Reacting Systems.

    ERIC Educational Resources Information Center

    Luss, Dan

    1986-01-01

    Analyzes steady-state multiplicity in chemical reactors, focusing on the use of two mathematical tools, namely, the catastrophe theory and the singularity theory with a distinguished parameter. These tools can be used to determine the maximum number of possible solutions and the different types of bifurcation diagrams. (JN)

  1. Childhood Giftedness, Adolescent Agency: A Systemic Multiple-Case Study

    ERIC Educational Resources Information Center

    Mudrak, Jiri; Zabrodska, Katerina

    2015-01-01

    Although considerable research has addressed development from childhood giftedness to adult excellence, subjective perceptions of this development by gifted individuals themselves have remained largely unexplored. This multiple case study examined the ways in which young adults, who in the past had been identified as gifted, made sense of their…

  2. Assessing Multiple Stakeholders' Perceptions of an Effective Principal Evaluation System

    ERIC Educational Resources Information Center

    Tran, Henry; Bon, Susan C.

    2015-01-01

    Existing principal evaluation research has failed to include the perspectives of multiple stakeholders. The present research study used focus group interviews to gather data about designing a principal evaluation process that includes these perspectives. Focus groups were conducted with principals, parents, certificated staff, and classified…

  3. A Low Noise, Microprocessor-Controlled, Internally Digitizing Rotating-Vane Electric Field Mill for Airborne Platforms

    NASA Technical Reports Server (NTRS)

    Bateman, M. G.; Stewart, M. F.; Blakeslee, R. J.; Podgorny, s. J.; Christian, H. J.; Mach, D. M.; Bailey, J. C.; Daskar, D.

    2006-01-01

    This paper reports on a new generation of aircraft-based rotating-vane style electric field mills designed and built at NASA's Marshall Spaceflight Center. The mills have individual microprocessors that digitize the electric field signal at the mill and respond to commands from the data system computer. The mills are very sensitive (1 V/m per bit), have a wide dynamic range (115 dB), and are very low noise (+/-1 LSB). Mounted on an aircraft, these mills can measure fields from +/-1 V/m to +/-500 kV/m. Once-per-second commanding from the data collection computer to each mill allows for precise timing and synchronization. The mills can also be commanded to execute a self-calibration in flight, which is done periodically to monitor the status and health of each mill.

  4. Technical basis for environmental qualification of microprocessor-based safety-related equipment in nuclear power plants

    SciTech Connect

    Korsah, K.; Wood, R.T.; Hassan, M.; Tanaka, T.J.

    1998-01-01

    This document presents the results of studies sponsored by the Nuclear Regulatory Commission (NRC) to provide the technical basis for environmental qualification of computer-based safety equipment in nuclear power plants. The studies were conducted by Oak Ridge National Laboratory (ORNL), Sandia National Laboratories (SNL), and Brookhaven National Laboratory (BNL). The studies address the following: (1) adequacy of the present test methods for qualification of digital I and C systems; (2) preferred (i.e., Regulatory Guide-endorsed) standards; (3) recommended stressors to be included in the qualification process during type testing; (4) resolution of need for accelerated aging for equipment to be located in a benign environment; and (5) determination of an appropriate approach for addressing the impact of smoke in digital equipment qualification programs. Significant findings from the studies form the technical basis for a recommended approach to the environmental qualification of microprocessor-based safety-related equipment in nuclear power plants.

  5. Optimization and Performance Modeling of Stencil Computations on Modern Microprocessors

    SciTech Connect

    Datta, Kaushik; Kamil, Shoaib; Williams, Samuel; Oliker, Leonid; Shalf, John; Yelick, Katherine

    2007-06-01

    Stencil-based kernels constitute the core of many important scientific applications on blockstructured grids. Unfortunately, these codes achieve a low fraction of peak performance, due primarily to the disparity between processor and main memory speeds. In this paper, we explore the impact of trends in memory subsystems on a variety of stencil optimization techniques and develop performance models to analytically guide our optimizations. Our work targets cache reuse methodologies across single and multiple stencil sweeps, examining cache-aware algorithms as well as cache-oblivious techniques on the Intel Itanium2, AMD Opteron, and IBM Power5. Additionally, we consider stencil computations on the heterogeneous multicore design of the Cell processor, a machine with an explicitly managed memory hierarchy. Overall our work represents one of the most extensive analyses of stencil optimizations and performance modeling to date. Results demonstrate that recent trends in memory system organization have reduced the efficacy of traditional cache-blocking optimizations. We also show that a cache-aware implementation is significantly faster than a cache-oblivious approach, while the explicitly managed memory on Cell enables the highest overall efficiency: Cell attains 88% of algorithmic peak while the best competing cache-based processor achieves only 54% of algorithmic peak performance.

  6. Gaussian systems for quantum-enhanced multiple phase estimation

    NASA Astrophysics Data System (ADS)

    Gagatsos, Christos N.; Branford, Dominic; Datta, Animesh

    2016-10-01

    For a fixed average energy, the simultaneous estimation of multiple phases can provide a better total precision than estimating them individually. We show this for a multimode interferometer with a phase in each mode, using Gaussian inputs and passive elements, by calculating the covariance matrix. The quantum Cramér-Rao bound provides a lower bound to the covariance matrix via the quantum Fisher information matrix, whose elements we derive to be the covariances of the photon numbers across the modes. We prove that this bound can be saturated. In spite of the Gaussian nature of the problem, the calculation of non-Gaussian integrals is required, which we accomplish analytically. We find our simultaneous strategy to yield no more than a factor-of-2 improvement in total precision, possibly because of a fundamental performance limitation of Gaussian states. Our work shows that no modal entanglement is necessary for simultaneous quantum-enhanced estimation of multiple phases.

  7. DISTURBANCE PATTERNS IN A SOCIO-ECOLOGICAL SYSTEM AT MULTIPLE SCALES

    EPA Science Inventory

    Ecological systems with hierarchical organization and non-equilibrium dynamics require multiple-scale analyses to comprehend how a system is structured and to formulate hypotheses about regulatory mechanisms. Characteristic scales in real landscapes are determined by, or at least...

  8. Microcprocessing Computer Technician, Digital and Microprocessor Technician Program. Post-Graduate 5th Year.

    ERIC Educational Resources Information Center

    Carangelo, Pasquale R.; Janeczek, Anthony J.

    Materials are provided for a two-semester digital and microprocessor technician postgraduate program. Prerequisites stated for the program include a background in DC and AC theory, solid state devices, basic circuit fundamentals, and basic math. A chronology of major topics and a listing of course objectives appear first. Theory outlines for each…

  9. An Ill-Structured PBL-Based Microprocessor Course without Formal Laboratory

    ERIC Educational Resources Information Center

    Kim, Jungkuk

    2012-01-01

    This paper introduces a problem-based learning (PBL) microprocessor application course designed according to the following strategies: 1) hands-on training without having a formal laboratory, and 2) intense student-centered cooperative learning through an ill-structured problem. PBL was adopted as the core educational technique of the course to…

  10. Cell cycle-dependent regulation of Aurora kinase B mRNA by the Microprocessor complex.

    PubMed

    Jung, Eunsun; Seong, Youngmo; Seo, Jae Hong; Kwon, Young-Soo; Song, Hoseok

    2014-03-28

    Aurora kinase B regulates the segregation of chromosomes and the spindle checkpoint during mitosis. In this study, we showed that the Microprocessor complex, which is responsible for the processing of the primary transcripts during the generation of microRNAs, destabilizes the mRNA of Aurora kinase B in human cells. The Microprocessor-mediated cleavage kept Aurora kinase B at a low level and prevented premature entrance into mitosis. The cleavage was reduced during mitosis leading to the accumulation of Aurora kinase B mRNA and protein. In addition to Aurora kinase B mRNA, the processing of other primary transcripts of miRNAs were also decreased during mitosis. We found that the cleavage was dependent on an RNA helicase, DDX5, and the association of DDX5 and DDX17 with the Microprocessor was reduced during mitosis. Thus, we propose a novel mechanism by which the Microprocessor complex regulates stability of Aurora kinase B mRNA and cell cycle progression.

  11. Multiple access capacity trade-offs for a Ka-band personal access satellite system

    NASA Technical Reports Server (NTRS)

    Dessouky, Khaled; Motamedi, Masoud

    1990-01-01

    System capability is critical to the economic viability of a personal satellite communication system. Ka band has significant potential to support a high capacity multiple access system because of the availability of bandwidth. System design tradeoffs are performed and multiple access schemes are compared with the design goal of achieving the highest capacity and efficiency. Conclusions regarding the efficiency of the different schemes and the achievable capacities are given.

  12. A FIRST COMPARISON OF KEPLER PLANET CANDIDATES IN SINGLE AND MULTIPLE SYSTEMS

    SciTech Connect

    Latham, David W.; Quinn, Samuel N.; Carter, Joshua A.; Holman, Matthew J.; Rowe, Jason F.; Borucki, William J.; Bryson, Stephen T.; Howell, Steve B.; Batalha, Natalie M.; Brown, Timothy M.; Buchhave, Lars A.; Caldwell, Douglas A.; Christiansen, Jessie L.; Dunham, Edward W.; Fabrycky, Daniel C.; Ford, Eric B.; Gautier, Thomas N. III

    2011-05-10

    In this Letter, we present an overview of the rich population of systems with multiple candidate transiting planets found in the first four months of Kepler data. The census of multiples includes 115 targets that show two candidate planets, 45 with three, eight with four, and one each with five and six, for a total of 170 systems with 408 candidates. When compared to the 827 systems with only one candidate, the multiples account for 17% of the total number of systems, and one-third of all the planet candidates. We compare the characteristics of candidates found in multiples with those found in singles. False positives due to eclipsing binaries are much less common for the multiples, as expected. Singles and multiples are both dominated by planets smaller than Neptune; 69{sup +2}{sub -3}% for singles and 86{sup +2}{sub -5}% for multiples. This result, that systems with multiple transiting planets are less likely to include a transiting giant planet, suggests that close-in giant planets tend to disrupt the orbital inclinations of small planets in flat systems, or maybe even prevent the formation of such systems in the first place.

  13. Analysis and Simulation of Disadvantaged Receivers for Multiple-Input Multiple-Output Communications Systems

    DTIC Science & Technology

    2010-09-01

    47 Figure 23. Simulated BER performance of a 2x2 MIMO-OFDM system with Alamouti space-time coding and 16 QAM modulation ...Spectral Density xiv PDF Probability Density Function QAM Quadrature Amplitude Modulation QPSK Quadrature Phase-Shift Keying RF Radio...of possible received symbols in a given modulation scheme (i.e., M- QAM ). It is clear that this will significantly reduce computational time

  14. Youngest Brown Dwarf Yet in a Multiple Stellar System

    NASA Astrophysics Data System (ADS)

    2000-07-01

    ... and the Sharpest Optical Image (0.18 arcsec) from the VLT so far...! Astronomers are eager to better understand the formation of stars and planets - with an eye on the complex processes that lead to the emergence of our own solar system some 4600 million years ago. Brown Dwarfs (BDs) play a special role in this context. Within the cosmic zoo, they represent a class of "intermediate" objects. While they are smaller than normal stars, they shine by their own energy for a limited time, in contrast to planets. Recent observations with the ESO Very Large Telescope (VLT) of a "young" Brown Dwarf in a multiple stellar system are taking on a particular importance in this connection. An evaluation of the new data by an international team of astronomers [1] shows that it is by far the youngest of only four such objects found in a stellar system so far. The results are now providing new insights into the stellar formation process. This small object is known as TWA-5 B and with a mass of only 15 - 40 times that of Jupiter, it is near the borderline between planets and Brown Dwarfs, cf. the explanatory Appendix to this Press Release. However, visible and infrared VLT spectra unambiguously classify it in the latter category. Accurate positional measurements with the Hubble Space Telescope (HST) and the VLT hint that it is orbiting the central, much heavier and brighter star in this system, TWA-5 A (itself a close double star of which each component presumably has a mass of 0.75 solar masses), with a period that may be as long as 900 years. And, by the way, an (I-band) image of the TWA-5 system is the sharpest delivered by the VLT so far, with an image size of only 0.18 arcsec [2]! Brown Dwarfs: a cool subject In current astronomical terminology, Brown Dwarfs (BDs) are objects whose masses are below those of normal stars - the borderline is believed to be about 8% of the mass of our Sun - but larger than those of planets, cf. [3]. Unlike normal stars, Brown Dwarfs are unable

  15. PC-based Multiple Information System Interface (PC/MISI) detailed design and implementation plan

    NASA Technical Reports Server (NTRS)

    Dominick, Wayne D. (Editor); Hall, Philip P.

    1985-01-01

    The design plan for the personal computer multiple information system interface (PC/MISI) project is discussed. The document is intended to be used as a blueprint for the implementation of the system. Each component is described in the detail necessary to allow programmers to implement the system. A description of the system data flow and system file structures is given.

  16. Shannon information capacity of time reversal wideband multiple-input multiple-output system based on correlated statistical channels

    NASA Astrophysics Data System (ADS)

    Yu, Yang; Bing-Zhong, Wang; Shuai, Ding

    2016-05-01

    Utilizing channel reciprocity, time reversal (TR) technique increases the signal-to-noise ratio (SNR) at the receiver with very low transmitter complexity in complex multipath environment. Present research works about TR multiple-input multiple-output (MIMO) communication all focus on the system implementation and network building. The aim of this work is to analyze the influence of antenna coupling on the capacity of wideband TR MIMO system, which is a realistic question in designing a practical communication system. It turns out that antenna coupling stabilizes the capacity in a small variation range with statistical wideband channel response. Meanwhile, antenna coupling only causes a slight detriment to the channel capacity in a wideband TR MIMO system. Comparatively, uncorrelated stochastic channels without coupling exhibit a wider range of random capacity distribution which greatly depends on the statistical channel. The conclusions drawn from information difference entropy theory provide a guideline for designing better high-performance wideband TR MIMO communication systems. Project supported by the National Natural Science Foundation of China (Grant Nos. 61331007, 61361166008, and 61401065) and the Specialized Research Fund for the Doctoral Program of Higher Education of China (Grant No. 20120185130001).

  17. Multiple IMU system hardware interface design, volume 2

    NASA Technical Reports Server (NTRS)

    Landey, M.; Brown, D.

    1975-01-01

    The design of each system component is described. Emphasis is placed on functional requirements unique in this system, including data bus communication, data bus transmitters and receivers, and ternary-to-binary torquing decision logic. Mechanization drawings are presented.

  18. Multiple System Atrophy with Orthostatic Hypotension (Shy-Drager Syndrome)

    MedlinePlus

    ... the onset of symptoms. A problem with the respiratory system is the most common cause of death. × Prognosis ... the onset of symptoms. A problem with the respiratory system is the most common cause of death. View ...

  19. GSFC conceptual design study for an inter-satellite Optical Multiple Access communication system

    NASA Technical Reports Server (NTRS)

    Fox, Neil; Maynard, Will; Clarke, Ernest; Bruno, Ronald

    1991-01-01

    System and terminal level specifications for an inter-satellite Optical Multiple Access (OMA) communication system are presented, as well as the resulting hardware designs for both OMA relay and OMA user terminals. The OMA relay terminal design uses a mechanical innovation which moves multiple fiber optic pickups in the focal plane, thereby providing simultaneous links with multiple OMA user terminals via a single telescope. Thus, with such a terminal on a relay satellite, multiple access service can be provided with a minimum of impact on the relay satellite.

  20. Real-time optical multiple object recognition and tracking system and method

    NASA Technical Reports Server (NTRS)

    Chao, Tien-Hsin (Inventor); Liu, Hua Kuang (Inventor)

    1987-01-01

    The invention relates to an apparatus and associated methods for the optical recognition and tracking of multiple objects in real time. Multiple point spatial filters are employed that pre-define the objects to be recognized at run-time. The system takes the basic technology of a Vander Lugt filter and adds a hololens. The technique replaces time, space and cost-intensive digital techniques. In place of multiple objects, the system can also recognize multiple orientations of a single object. This later capability has potential for space applications where space and weight are at a premium.