Science.gov

Sample records for multisite spectroscopic observations

  1. Spectroscopic Observations of Merging Galaxies

    NASA Astrophysics Data System (ADS)

    Donzelli, C. J.; Pastoriza, M. G.

    2000-07-01

    In this paper we describe the spectroscopic and infrared properties of a sample of 25 merging galaxy pairs, selected from the catalog of Arp & Madore, and we compare them with those observed in a similar sample of interacting galaxies (Donzelli & Pastoriza). It is noted that mergers as well as interacting systems comprise a wide range of spectral types, going from those corresponding to well-evolved stellar populations (older than 200 Myr) to those that show clear signatures of H II regions with stellar populations younger than 8 Myr. However, merger galaxies show on average more excited spectra than interacting pairs, which could be attributed to lower gas metallicity. From the emission lines we also found that merging systems show on average higher (about a factor of 2) star formation rates than interacting galaxies. Classical diagnostic diagrams show that only three of 50 of the galaxies (6%) present some form of nuclear activity: two Seyfert galaxies and one LINER. However, through a detailed analysis of the pure emission-line spectra, we conclude that this fraction may raise up to 23% of the mergers if we consider that some galaxies host a low-luminosity active nucleus surrounded by strong star-forming regions. This latter assumption is also supported by the infrared colors of the galaxies. Regarding to the total infrared luminosities, the merging galaxies show on average an IR luminosity, log(Lir)=10.7, lower than that of interacting systems, log(Lir)=10.9. We find that only three mergers of the sample (12%) can be classified as luminous infrared galaxies, while this fraction increases to 24% in the interacting sample. Based on observations made at CASLEO. Complejo Astronómico El Leoncito is operated under agreement between the Consejo Nacional de Investigaciones Científicas y Técnicas de la República Argentina and the National Universities of La Plata, Córdoba and San Juan.

  2. Unification of VW Arietis observations obtained in multisite campaign.

    NASA Astrophysics Data System (ADS)

    Dorokhova, T. N.

    1999-04-01

    The two-channel photometric observations of the δ Scuti star VW Arietis (BDS 1269A) obtained at the Mt. Dushak-Erekdag Station of the Odessa Astron. Obs., Turkmenistan, were combined with the STEPHI Network four-channel photometry made at Xinglong Obs., China, and Observatorio del Teide, Spain, during the same season. The data set 164.9 hours long (16 days in October 1993) was analyzed. A five-frequency solution is proposed at the present stage of investigation. The suggestion that VW Arietis belongs to a small group of peculiar λ Bootis stars removes some contradictions in previous results, the existence of a binary system with a peculiar and a normal star finds a natural explanation. A possible pulsation mode identification is suggested.

  3. Using a Two-Staged Propensity Score Matching Strategy and Multilevel Modeling to Estimate Treatment Effects in a Multisite Observational Study

    ERIC Educational Resources Information Center

    Rickles, Jordan H.

    2012-01-01

    The study is designed to demonstrate and test the utility of the proposed two-stage matching method compared to other analytic methods traditionally employed for multisite observational studies. More specifically, the study addresses the following research questions: (1) How do different specifications of the matching method influence covariate…

  4. Speckle observations of visual and spectroscopic binaries. IV

    NASA Astrophysics Data System (ADS)

    Miura, Noriaki; Baba, Naoshi; Ni-Ino, Mikinori; Ohtsubo, Junji; Noguchi, Motokazu; Isobe, Syuzo

    This is the fourth paper of this series giving results of speckle observations for 22 visual and 161 spectroscopic binaries. The observation was carried out by using the 212 cm telescope of San Pedro Martir Observatory in Mexico on 7 nights from July 20 to July 26, 1991. We obtained fringes in power spectra of 19 visual and 11 spectroscopic binaries (6 newly resolved ones) with angular separation larger than 0.06 arcsec. We introduced a new ICCD TV camera in this observation, and were able to achieve the diffraction-limit resolution of the 212 cm telescope.

  5. Theoretical backgrounds for interpretation of spectroscopic observations

    NASA Astrophysics Data System (ADS)

    Hadrava, P.

    2013-02-01

    The advantage of analysis of observed data using their fit with theoretical model of the directly observed quantities is shown as well as the need for simultaneous solution of all available data. Some particular problems of disentangling of stellar spectra and model atmospheres of component stars of multiple systems are discussed.

  6. Spectroscopic observations of comet Kohoutek (1973f)

    NASA Technical Reports Server (NTRS)

    Kohoutek, L.; Rahe, J.

    1976-01-01

    Coude spectrograms of comet Kohoutek obtained with the ESO 152-cm telescope in La Silla, Chile are discussed. Emission features of the C3, CH, and CO(+) molecules found in the blue region of the spectrum are considered along with measured emissions in the visual region of the spectrum. The observational and cometary data are given in tabular form.

  7. A Two-Stage Propensity Score Matching Strategy for Treatment Effect Estimation in a Multisite Observational Study

    ERIC Educational Resources Information Center

    Rickles, Jordan H.; Seltzer, Michael

    2014-01-01

    When nonrandom treatments occur across sites, within-site matching (WM) is often desirable. This approach, however, can significantly reduce treatment group sample size and exclude substantively important subgroups. To limit these drawbacks, we extend a matching approach developed by Stuart and Rubin to a multisite study. We demonstrate the…

  8. Using and Experiencing the Academic Library: A Multisite Observational Study of Space and Place

    ERIC Educational Resources Information Center

    May, Francine; Swabey, Alice

    2015-01-01

    This study examines how students are using academic library spaces and the role these spaces are playing in the campus community. Data were collected on five campuses (two community colleges, two undergraduate universities, and one technical institute) via observational seating sweeps and questionnaires. The study found remarkably similar usage…

  9. Unification of the VW Arietis observation results obtained in multisite campaign.

    NASA Astrophysics Data System (ADS)

    Dorokhova, T. N.

    Results of the two-channel photometric observations of the δ Sct star VW Ari (BDS 1269 A) made at the Mt. Dushak-Erekdag Station of the Odessa Astronomical Observatory (Turkmenistan) were combined with the STEPHI network four-channel photometry made at the Xinglong Observatory (China) and Observatorio del Teide (Spain) during the same season. A five-frequency solution is proposed at the present stage of investigation. The suggestion that VW Ari belongs to the small group of peculiar λ Boo stars eliminates some discrepancies in the earlier results, and the existence of a binary system with a star with a peculiar abundance and a star with the normal abundance finds its natural explanation. A possible identification of pulsation modes is suggested.

  10. Multi-site model-observations comparison shows the diurnal effects of hydrodynamic stress on evapotranspiration

    NASA Astrophysics Data System (ADS)

    Matheny, A. M.; Bohrer, G.

    2013-12-01

    Hydraulic limitations are known to control transpiration in forest ecosystems when the soil is drying or when the vapor pressure deficit between the air and stomata is very large, but they can also impact stomatal apertures under conditions of adequate soil moisture and lower evaporative demand. We use the NACP dataset of latent heat flux (LE) measurements and model observations for multiple site/model intercomparisons to evaluate the degree to which currently un-resolved high-frequency (sub-daily) hydrodynamic stresses affect the error in model prediction of latent heat flux. Particularly, we see that models have difficulty resolving the dynamics of intra-daily hysteresis. We hypothesize that this is a result of un-resolved afternoon stomata closure due to hydrodynamic stresses. We find that although no model or stomata parameterization was consistently best or worst in terms of ability to predict LE, errors in model-simulated LE were consistently largest and most variable when soil moisture and VPD were moderate to limiting. This suggests that models have trouble simulating the dynamics that cause stomata to close due to high VPD and moderate to low soil-water availability. Errors in LE occur most frequently when vegetative dynamics dominate. The majority of models tend to underestimate LE in the pre-noon hours and overestimate in the late evening. These diurnal error patterns are consistent with models' diminished ability to accurately simulate the natural hysteresis of transpiration. Nearly all models demonstrate a marked tendency to underestimate the degree of maximum hysteresis which, across all sites studied, is most pronounced during moisture limited conditions. The assumed empirical or semi-empirical coupling between stomatal conductance and soil moisture used by these current models does not resolve the hydrodynamic process of water movement from the soil to the leaves. This approach does not take advantage of advances in our understanding of water flow

  11. Development and initial validation of the Observer-Rated Housing Quality Scale (OHQS) in a multisite trial of housing first.

    PubMed

    Adair, Carol E; Kopp, Brianna; Lavoie, Jennifer; Distasio, Jino; Hwang, Stephen W; Watson, Aimee; Veldhuizen, Scott; Chislett, Katherine; Voronka, Jijian; Ahmad, Muznah; Ahmed, Naveed; Goering, Paula

    2014-04-01

    Quality of housing has been shown to be related to health outcomes, including mental health and well-being, yet "objective" or observer-rated housing quality is rarely measured in housing intervention research. This may be due to a lack of standardized, reliable, and valid housing quality instruments. The objective of this research was to develop and validate the Observer-Rated Housing Quality Scale (OHQS) for use in a multisite trial of a "housing first" intervention for homeless individuals with mental illness. A list of 79 housing unit, building, and neighborhood characteristics was generated from a review of the relevant literature and three focus groups with consumers and housing service providers. The characteristics were then ranked by 47 researchers, consumers, and service providers on perceived importance, generalizability, universality of value, and evidence base. Items were then drafted, scaled (five points, half values allowed), and pretested in seven housing units and with seven raters using cognitive interviewing techniques. The draft scale was piloted in 55 housing units in Toronto and Winnipeg, Canada. Items were rated independently in each unit by two trained research assistants and a housing expert. Data were analyzed using classical psychometric approaches and intraclass correlation coefficients (ICC) for inter-rater reliability. The draft scale consisted of 34 items assessing three domains: the unit, the building, and the neighborhood. Five of 18 unit items and 3 of 7 building items displayed ceiling or floor effects and were adjusted accordingly. Internal consistency was very good (Cronbach's alpha = 0.90 for the unit items, 0.80 for the building items, and 0.92 total (unit and building)). Percent agreement ranged from 89 to 100 % within one response scale value and 67 to 91 % within one half scale value. Inter-rater reliability was also good (ICCs were 0.87 for the unit, 0.85 for the building, and 0.93 for the total scale). Three

  12. Spectroscopic observations of spatial and temporal variations on Venus

    NASA Technical Reports Server (NTRS)

    Young, A. T.; Young, L. G.; Woszczyk, A.

    1974-01-01

    Details of the Table Mountain spectroscopic patrol of Venus in September-October 1972 are given. The data indicate systematic variation over the disc, with more CO2 absorption near the terminator than at the limb, and slightly more in the southern than in the northern hemisphere. The semiregular four-day variation, reported to occur simultaneously over the disk at 8689 A by Young et al. (1973), is confirmed by observations of the 7820 A and 7883 A CO2 bands.

  13. On VI Imaging Instrumentation and Spectroscopic Observations in Supernova Remnants

    NASA Astrophysics Data System (ADS)

    Beasley, M. N.

    2003-12-01

    For my thesis, I designed and built a high resolution imaging spectrograph, the Imaging Spectrograph for Interstellar Shocks (ISIS), that flew on a sub-orbital rocket from White Sands Missile Range on November 18th, 2002. This rocket-borne instrument was designed to image hot plasma at O vi λ λ 1032/1038 Å \\space behind a shock front in the Cygnus Loop. The new type of instrument developed for this application is a novel type of spectrograph that relies on a standard telescope for its optical layout. This layout, in conjunction with aberration-corrected holography, is capable of arcsecond quality imaging in diffracted light while maintaining arcsecond imaging at the telescope focus. The follow-up research is based on observations of N132D, a young, oxygen rich supernova remnant in the Large Magellanic Cloud. These new spectroscopic observations from the Far Ultraviolet Spectroscopic Explorer of emitting O vi in the shocked stellar ejecta were used to distinguish between different models of the ejecta and demonstrate that there is lack of appropriate observations of this type of remnant. This work was supported by NASA grants NAG5-5096, NAG5-7465, NAG5-8955, and NAG5-10319. M. Beasley was supported by a Graduate Student Research Program fellowship NGT5-50340.

  14. On VI imaging instrumentation and spectroscopic observations in supernova remnants

    NASA Astrophysics Data System (ADS)

    Beasley, Matthew Nelson

    2003-10-01

    For my thesis project, I designed and built a high resolution imaging spectrograph, the Imaging Spectrograph for Interstellar Shocks (ISIS), that flew on a sub-orbital rocket from White Sands Missile Range on November 18th, 2002. This rocket-borne instrument was designed to image hot plasma at O VI lambdalambda1032/1038 A behind a shock front in the Cygnus Loop. The new type of instrument developed for this application is a novel type of spectrograph that relies on a standard telescope for its optical layout. This layout, in conjunction with aberration-corrected holography, is capable of arcsecond quality imaging in diffracted light while maintaining an arcsecond image at the telescope focus. The follow-up research is based on observations of N132D, a young, oxygen rich supernova remnant in the Large Magellanic Cloud. These new spectroscopic observations from the Far Ultraviolet Spectroscopic Explorer of emitting O VI in the shocked stellar ejecta were used to distinguish between different models of the ejecta and demonstrate that there is lack of appropriate observations of this type of remnant.

  15. Irradiation effects on canvas oil painting: Spectroscopic observations

    NASA Astrophysics Data System (ADS)

    Manea, Mihaela Maria; Negut, C. D.; Stanculescu, Ioana Rodica; Ponta, C. C.

    2012-10-01

    "Winter" oil painting, by Romanian contemporary artist George Alexandrescu was used as experimental model for the substantiation of gamma radiation treatment, as the best choice to stop the biological attack of paintings. In this purpose, spectroscopic and colorimetric methods were used to analyse in situ, non-destructively and non-contact, the experimental model before and after 60Co gamma irradiation. Chemical structure and colour changes were monitored by FTIR, FT-Raman and Vis reflectance spectroscopy. Negligible Infrared spectral transformations have been observed after irradiation. Furthermore, it was found that gamma irradiation did not induce any significant colour alterations. Insignificant structural and colour changes observed, recommend the use of gamma irradiation in the disinfection of oil paintings.

  16. Spectroscopic and video observations of fullerene production arcs

    SciTech Connect

    Lorents, D.C.; Stalder, K.R.; Keegan, D.M.; Ruoff, R.S.; Malhotra, R.M.

    1993-12-01

    Spatially resolved spectroscopic studies of a carbon arc operating under fullerene production conditions have been made across the visible wavelength range using an imaging Optical Multichannel Analyzer. C{sub 2} Swan bands are observed to be the major visible emissions although strong CI and CII as well as He I atomic lines are also observed. Video and photographic studies of the arc characteristics show the Swan-band emissions to be concentrated most intensely near the anode but also to appear strongly in regions well outside the electrode gap region. Vibrational and rotational temperatures of these bands provide information on the temperatures in various regions of the arc. The characteristic spatial structure of the arcs observed in the Swan-band light suggests that they are excited by electrons whose trajectories are controlled by the local electric and magnetic fields. The arc exhibits complex and interesting temporal behavior that has been observed with a video camera using short exposure times. Video film taken through a Swan-band filter clearly shows the dominant spatial features of the C{sub 2} emissions.

  17. Spectroscopic observations of the exoplanet WASP-32b transit

    NASA Astrophysics Data System (ADS)

    Grauzhanina, A. O.; Valyavin, G. G.; Gadelshin, D. R.; Baklanova, D. N.; Plachinda, S. I.; Antonyuk, K. A.; Pit, N. V.; Galazutdinov, G. A.; Valeev, A. F.; Burlakova, T. E.; Kholtygin, A. F.

    2017-01-01

    We present first results of spectroscopic observations of transiting exoplanets in the Special Astrophysical Observatory of the Russian Academy of Sciences with the Main Stellar Spectrograph of the 6-m BTA telescope. For the exoplanetWASP-32b, we detected a significant variation of intensity and equivalent width in the Hα spectral line of the parent star at the time of a transit. The equivalent width of the line during transit is by 8-10% larger than outside the planet passage. Residual intensity in the core of the line reveals the following tendency: the line is by 10-15% deeper inside transit than outside it. Observations with the long-slit spectrograph of the Crimean Astrophysical Observatory at the 2.6-m ZTSh telescope also showed a transit event in the Hα line, although, with a smaller amplitude and shape inverted in relation to the data from the 6-m telescope. While in the observations with the BTA the Hα line becomes deeper during the transit, in the ZTSh observations, the residual intensity of the Hα line decreases during the transit. Reducing and analysis of the archive data of WASP-32b observations with the HARPS spectrograph also confirm the Hα line modulation at the time of the transit. The observed data give evidence of the envelope in WASP-32b filling the Roche lobe and a comet-like tail of changing geometry and orientation relative to the observer. These changes determine different depths and shapes of the Hα spectral line at the time of transits.

  18. ISO spectroscopic observations of short-period comets

    NASA Astrophysics Data System (ADS)

    Crovisier, J.; Encrenaz, Th.; Lellouch, E.; Bockelée-Morvan, D.; Altieri, B.; Leech, K.; Salama, A.; Griffin, M. J.; de Graauw, Th.; van Dishoeck, E. F.; Knacke, R.; Brooke, T. Y.

    1999-03-01

    Two Infrared Space Observatory programmes (guaranteed time and open time) were devoted to high-resolution spectroscopic observations of short-period comets. 22P/Kopff was observed on October-December 1996 with SWS and LWS. Due to the weakness of the object, only the ν3 ro-vibrational lines of water were detected, with SWS. Comet 103P/Hartley 2 was observed close to its perihelion (at 1.04 AU from Sun and 0.82 AU from Earth) on January 1998 with SWS, LWS and CAM. The bands of H2O and CO2 at 2.7 and 4.3 μm are detected, with [CO2]/[H2O] = 10 %. The 2.7 μm band of H2O is observed with a high signal-to-noise ratio with SWS, which permits to evaluate the rotational temperature of water to 16-20 K and its ortho-to-para ratio to ~ 2.7, corresponding to a spin temperature of ~ 35 K. The 5-17 μm spectrum of comet Hartley 2 observed with CAM-CVF shows the 9-12 μm signature of silicates. Silicate emission around 10 μm is present at a level of about 20 % of the continuum, with a peak at 11.3 μm indicative of crystalline silicates. This is the first time crystalline silicates are found in a short-period comet. The ISO observations of the Jupiter-family comet P/Hartley 2, presumably originating from the Edgeworth-Kuiper belt, are compared to those of comet Hale-Bopp which came from the Oort cloud.

  19. Spectroscopic observations of the optical candidate for Cygnus X-1.

    NASA Technical Reports Server (NTRS)

    Brucato, R.; Kristian, J.

    1973-01-01

    The spectroscopic binary BD+34 3815 (= HDE 226868) with a period of 5.6 days, which is the brightest object in the position box for the X-ray source Cyg X-1, is studied to determine whether it meets all the requirements for being a black hole. Evidence is presented that the mass of the secondary is larger than the upper limits for white dwarfs or neutron stars, but there is no conclusive evidence that the optical binary is an X-ray source, and that the secondary is a collapsed object.

  20. Patterns and loss of sexual activity in the year following hospitalization for acute myocardial infarction (a United States National Multisite Observational Study).

    PubMed

    Lindau, Stacy Tessler; Abramsohn, Emily; Gosch, Kensey; Wroblewski, Kristen; Spatz, Erica S; Chan, Paul S; Spertus, John; Krumholz, Harlan M

    2012-05-15

    A multisite observational study of sexual activity-related outcomes in patients enrolled in the TRIUMPH registry during hospitalization for an acute myocardial infarction (AMI) was conducted to identify patterns and loss of sexual activity 1 year after hospitalization for AMI. Gender-specific multivariable hierarchical models were used to identify correlates of loss of sexual activity including physician counseling. Main outcome measurements included "loss of sexual activity" (less frequent or no sexual activity 1 year after an AMI in those who were sexually active in the year before the AMI) and 1-year mortality. Mean ages were 61.1 years for women (n = 605) and 58.6 years for men (n = 1,274). Many were sexually active in the year before and 1 year after hospitalization (44% and 40% of women, 74% and 68% of men, respectively). One third of women and 47% of men reported receiving hospital discharge instructions about resuming sex. Those who did not receive instructions were more likely to report loss of sexual activity (women, adjusted relative risk 1.44, 95% confidence interval 1.16 to 1.79; men, adjusted relative risk 1.27, 95% confidence interval 1.11 to 1.46). One year mortality after AMI was similar in those who reported sexual activity in the first month after AMI (2.1%) and those who were sexually inactive (4.1%, p = 0.08). In conclusion, although many patients were sexually active before AMI, only a minority received discharge counseling about resuming sexual activity. Lack of counseling was associated with loss of sexual activity 1 year later. Mortality was not significantly increased in patients who were sexually active soon after their AMI.

  1. Multi-site Observations of the March 2016 Total Solar Eclipse: Calibration of Images to Simulate Continuous Monitoring

    NASA Astrophysics Data System (ADS)

    Bosh, Robert; Penn, Matthew J.; McKay, Myles; Baer, Robert; Garrison, David; Gelderman, Richard; Hare, Honor; Isberner, Fred; Jensen, Logan; Kovac, Sarah; Mitchell, Adriana; Pierce, Michael; Thompson, Patricia; Ursache, Andrei; Varsik, John R.; Walter, Donald K.; Watson, Zachary; Young, David; Citizen Cate Team

    2017-01-01

    During the total solar eclipse of March 9, 2016, five teams of astronomers participating in the Citizen Continental America Telescopic Eclipse (CATE) experiment, traveled to different locations in Indonesia to observe the eclipse. Data was acquired to continuously monitor the progression of features in the inner solar corona: a region of the solar atmosphere where time evolution is not well understood. Image data from the eclipse consisted of sets of 7 exposure times 0.4, 1.3, 4, 13, 40, 130, and 400 milliseconds which are used to create a high dynamic range composite image. Eclipse data from these sites were then processed and calibrated using sets of dark and flat images. Further data processing included the compilation of exposures into high dynamic range images and were subsequently spatially filtered. Using these processing techniques, data from each site was aligned and compiled as frames in videos of the eclipse, each consisting of over 140 frames with the goal of being combined. Lessons learned from the data obtained in the observations of the 2016 total solar eclipse are being used to improve the procedure which will be used in the CATE experiment during the North American 2017 total solar eclipse.

  2. Estimating CH4 and CO Emissions in California's Urban and Rural Regions Using Multi-site Observations

    NASA Astrophysics Data System (ADS)

    Jeong, S.; Andrews, A. E.; Bianco, L.; Graven, H. D.; Hsu, Y.; Newman, S.; Novakovskaia, E.; Vaca, P.; Salameh, P.; Sloop, C.; Weiss, R. F.; Keeling, R. F.; Fischer, M. L.

    2013-12-01

    California's commitment (Assembly Bill 32) to reduce total greenhouse gas (GHG) emissions to 1990 levels by 2020 (~20% reduction) requires quantification of current GHG emissions. We will present atmospheric inversion estimates of California's total CH4 emissions for summer 2013, using data from multiple sites covering urban and rural areas of California's South Coast Air Basin (SoCAB), Central Valley, and San Francisco Bay Area. We will also use measured CO from two tall-tower sites (Central Valley and SoCAB) to quantify CO emissions as well as to evaluate atmospheric transport. We use Bayesian inverse modeling to estimate the CH4 and CO emissions from discrete regions of California by combining the atmospheric measurements, upstream background, high-resolution prior emission maps, and predicted atmospheric transport from WRF-STILT. We quantify site-specific model-measurement uncertainties due to transport using meteorological data from a network of atmospheric profilers and in-situ sensors, due to background using oceanic and aircraft observations, and the prior emissions. To reduce the uncertainty in transport, we assimilate available meteorological measurements from surface and upper air stations, and wind profilers into the WRF model. Preliminary inversion results during September 2010 - June 2011 and summer of 2012 suggest that state total CH4 emissions are 1.2 - 1.8 times higher than the current CARB inventory and we will update these estimates. We expect the results of this study will significantly improve upon existing work in quantifying CH4 and CO emissions in California's urban and rural regions.

  3. Spectroscopic observations of X-ray selected late type stars

    NASA Technical Reports Server (NTRS)

    Takalo, L. O.

    1988-01-01

    A spectroscopic survey of nine X-ray selected late type stars was conducted. These stars are serendipitously discovered EINSTEIN X-ray sources, selected from two large x-ray surveys: the Columbia Astrophysical Laboratory survey (five stars) and the CFA Medium Sensitivity survey (four stars). Four of the Columbia survey stars were found to be short period binaries. The fifth was found to be an active single G dwarf. None of the Medium Sensitivity survey stars were found to be either binaries or active stars. Activity was measured by comparing the H-alpha and the CaII infrared triplet (8498, 8542) lines in these stars to the lines in inactive stars of similar spectral type. A correlation was found between the excess H-alpha lime emission and V sin(i) and between the excess H-alpha line emission and X-ray luminosity. No correlation was found between the infrared line emission and any other measured quantity.

  4. Spectroscopic and photometric observations of M supergiants in Carina.

    NASA Technical Reports Server (NTRS)

    Humphreys, R. M.; Strecker, D. W.; Ney, E. P.

    1972-01-01

    Spectroscopic study of 30 Southern-Hemisphere M supergiants mostly in Carina in the blue and near-infrared, and photometrical study of these stars from 0.4 to 18 microns. The uncertainties in the determinations of interstellar extinction are discussed, and the spatial distribution of the M supergiants in the Carina arm is shown. The presence of the 11-micron excess attributed to silicate dust is a common feature. Stars of the same spectral type and luminosity class are remarkably homogeneous in their long-wave behavior. The silicate feature becomes more prominent in the more luminous stars and in stars of later spectral type. Four composite systems show little long-wave excess. The two VV Cephei objects have excesses probably produced by gas emission, and the other two have little or no excess - supporting the suggestion that the presence of the early star prohibits the formation of a dust envelope. Three stars - VY CMa, VX Sgr, and HD 9767 - appear to be extreme examples of stars with large excesses over the entire long-wave region. It is suggested that these objects are surrounded by large amounts of particulate material over a great range of distances from the stars.

  5. Spectroscopic Observations of the Bright Afterglow of GRB021004

    NASA Astrophysics Data System (ADS)

    Harrison, Fiona

    2001-09-01

    One of the holy grails of gamma-ray burst research is to detect X-ray line signatures from an afterglow with high statistical significance. Of all possible observations, this perhaps offers the best chance of constraining the GRB mechanism and environment, and could provide the "smoking gun" signature connecting GRBs to massive stellar deaths. In order to accomplish this, we know long observations within one day of the event are necessary.

  6. HERSCHEL SPECTROSCOPIC OBSERVATIONS OF LITTLE THINGS DWARF GALAXIES

    SciTech Connect

    Cigan, Phil; Young, Lisa; Cormier, Diane; Lebouteiller, Vianney; Madden, Suzanne; Brinks, Elias; Elmegreen, Bruce; Schruba, Andreas; Heesen, Volker; Collaboration: LITTLE THINGS Team

    2016-01-15

    We present far-infrared (FIR) spectral line observations of five galaxies from the Little Things sample: DDO 69, DDO 70, DDO 75, DDO 155, and WLM. While most studies of dwarfs focus on bright systems or starbursts due to observational constraints, our data extend the observed parameter space into the regime of low surface brightness dwarf galaxies with low metallicities and moderate star formation rates. Our targets were observed with Herschel at the [C ii] 158 μm, [O i] 63 μm, [O iii] 88 μm, and [N ii] 122 μm emission lines using the PACS Spectrometer. These high-resolution maps allow us for the first time to study the FIR properties of these systems on the scales of larger star-forming complexes. The spatial resolution in our maps, in combination with star formation tracers, allows us to identify separate photodissociation regions (PDRs) in some of the regions we observed. Our systems have widespread [C ii] emission that is bright relative to continuum, averaging near 0.5% of the total infrared (TIR) budget—higher than in solar-metallicity galaxies of other types. [N ii] is weak, suggesting that the [C ii] emission in our galaxies comes mostly from PDRs instead of the diffuse ionized interstellar medium (ISM). These systems exhibit efficient cooling at low dust temperatures, as shown by ([O i]+[C ii])/TIR in relation to 60 μm/100 μm, and low [O i]/[C ii] ratios which indicate that [C ii] is the dominant coolant of the ISM. We observe [O iii]/[C ii] ratios in our galaxies that are lower than those published for other dwarfs, but similar to levels noted in spirals.

  7. SOHO/UVCS spectroscopic observations of coronal oscillations

    NASA Astrophysics Data System (ADS)

    Mancuso, Salvatore; Raymond, John C.; Rubinetti, Sara; Taricco, Carla

    2016-06-01

    We analyzed the temporal evolution of the intensities and Doppler shifts of two sets of high-cadence sit-and-stare observations acquired with the Ultraviolet Coronagraph Spectrometer (UVCS) on board the Solar and Heliospheric Observatory (SOHO) satellite to detect the possible signature of wave and oscillatory motions in the solar corona. The first set of data consisted of H I Lyα observations collected on 1997 December 14 at 1.43 RS above the eastern limb of the Sun. Spectral analysis of the data revealed clear Doppler-shift oscillations with period P = 14.3 min over a portion of the UVCS slit. The origin of these oscillations is attributable to the excitation of propagating fast-mode magnetoacoustic kink waves along a narrow, jet-like ejection observed higher up in the white-light corona. The second set of data consisted of O VI 1032 Å observations collected on 1996 December 19 at 1.38 RS above the north polar coronal hole. In this case, clear intensity oscillations (P = 19.5 min) and Doppler-shift oscillations (P = 7.2 min) over two different portions of the UVCS slit were detected. The origin of these oscillations is attributable to the excitation of slow-mode magnetoacoustic waves propagating along polar plumes that may partially account for heating of the plasma in the corona.

  8. Spectroscopic Observations of the 2011 Draconids Meteor Shower

    NASA Astrophysics Data System (ADS)

    Rudawska, Regina; Zender, Joe; Jenniskens, Peter; Vaubaillon, Jeremie; Koten, Pavel; Margonis, Anastasios; Tóth, Juraj; McAuliffe, Jonathan; Koschny, Detlef

    2014-08-01

    Some past October Draconid shower meteoroids fell apart in a spray of fragments at the end of their trajectory before slowing down, from which it was concluded that these were among the most fragile meteoroids known. In those instances, the dust could not be reliably traced to a particular return of the parent comet 21P/Giaconini-Zinner. On October 8th, 2011, Earth was predicted to transverse the 1900 A.D. dust ejecta of the comet. In 1900, the comet's perihelion distance first moved significantly inwards to the Sun and ejection conditions could have been unusual. An airborne observing campaign was organized, with several teams contributing imaging and spectrographic cameras to study the manner in which these meteoroids released the volatile element sodium during the ablation process in the Earth's atmosphere. IMCCE, ESA, and the SETI Institute contributed spectrographic cameras based on low-light WATEC 902H2 Ultimate, low-light LCC1, and GenII XX1332 image intensified cameras. An outburst was observed, much as predicted. Despite a lack of bright meteors, a total of 15 Draconid spectra were recorded. All show evidence of an early release of sodium. The loss of sodium was observed to coincide with the formation of a distinct wake of fragments. The observations show that 21P/Giacobini-Zinner ejected fragile meteoroids during the return in 1900. Those grains may have lost some sodium even before impacting Earth.

  9. ISO Far-Infrared Spectroscopic Observations of Jupiter

    NASA Astrophysics Data System (ADS)

    Burgdorf, M. J.; Encrenaz, Th.; Feuchtgruber, H.; Davis, G. R.; Fouchet, Th.; Gautier, D.; Lellouch, E.; Orton, G. S.; Sidher, S. D.

    2001-07-01

    We present the far-infrared spectrum of Jupiter that was measured with the Short and Long Wavelength Spectrometers (SWS and LWS) aboard the Infrared Space Observatory (ISO). The region between 38 and 44 microns was observed in grating mode, where the SWS provides a spectral resolution of about 1300. For longer waves up to 197 microns the LWS-FP (Fabry-Perot) was used to achieve a resolution of several thousand. The observations were made between 23 and 26 May 1997 during ISO's revolutions 554, 556 and 557. The Jovian spectrum in the far-infrared is compared to an atmospheric radiative transfer model using expected values for the vertical profiles of the atmospheric constituents. Rotational transitions of ammonia and phosphine are responsible for the absorption features observed: Strong ammonia absorption manifolds are obvious against the background continuum slope, appearing at 39, 42, 46, 51, 56, 63, 72, 84, 100 and 125 microns in both the data and the model. Also PH3 features are present at the expected wavelengths of 113 and 141 microns in both the data and the model. This is the first time that most of these far-infrared features have been detected. The ISO observations are therefore of interest for the preparation of the planned submillimeter studies of the atmospheres of the Jovian planets with FIRST.

  10. Spectroscopic observations of southern nearby galaxies. I. NGC 2442

    NASA Astrophysics Data System (ADS)

    Bajaja, E.; Agüero, E.; Paolantonio, S.

    1999-04-01

    The galaxy NGC 2442 was observed with a REOSC spectrograph, installed in the 2.15 m CASLEO telescope, in order to derive galactic parameters from the observed optical lines and to compare them with the results of radioastronomical observations made in the continuum, at 843 MHz, with the MOST and in the CO lines with the SEST telescope. Recent publications allowed us to extend the comparison to results from interferometric observations of Hα and H I 21 cm lines and of the continuum at 1415 MHz. The long slit observations were made placing the 5farcm 8 slit at six different positions on the optical image of the galaxy. The emission line intensity ratios at the nuclear region indicate that NGC 2442 is a LINER. The electron temperature and volume density are Te ~ 14 000 K and Ne ~ 530 cm(-3) , respectively. In contrast, a spectrum of a region 87arcsec to the NE shows the typical characteristics of a H Ii region. In this case Te ~ 6,500 K and Ne ~ 10 cm(-3) . Good correlations between the distributions of intensities, velocity fields and rotation curves have been found for the optical and radio lines. It is shown that the three intensity peaks along the line at PA = 40degr were not resolved by the observations at radio frequencies. The steep central rotation curve seen in CO has been confirmed and improved showing the existence of a disc or a ring, with a radius of 12.5 arcsec, rotating at 216/sin(i) km s(-1). Two velocity components in three optical spectra obtained in the nuclear region, have been related to two small Hα regions close to the nucleus and to the central ring. Asymmetries in the distributions of the emitting sources and irregularities in their velocity fields indicate the need of modelling the galaxy before any dynamical study is attempted. Based on observations made in the Complejo Astronomico El Leoncito, operated under agreement between the Consejo Nacional de Investigaciones Cientificas y Tecnicas de la Republica Argentina and the National

  11. Infrared imaging-spectroscopic observations of Venus atmosphere

    NASA Astrophysics Data System (ADS)

    Ohtsuki, Shoko; Sagawa, Hideo; Ueno, Munetaka

    2005-01-01

    We present a report on our recent observations of Venus atmosphere which we have performed in infrared wavelength at Okayama Astrophysical Observatory. The data show important results on the CO distribution and on O2 IRA (0,0) 1.27μm airglow in the atmosphere. The infrared windows of the Venusian atmosphere are rather developing areas and will give us important information on the dynamics of Venus atmosphere.

  12. A Spectroscopic Census of L Dwarfs Observed By Gaia

    NASA Astrophysics Data System (ADS)

    Marocco, Federico; Smart, Richard L.; Caballero, José A.; Pinfield, David J.; Beamín, Juan Carlos; Jones, Hugh R. A.; Cabrera-Lavers, Antonio; García-Álvarez, David

    2016-08-01

    The ESA cornerstone mission Gaia will revolutionise astronomy observing objects as diverse as minor planets, stars,and galaxies out to QSOs. We estimate that Gaia will observe directly 500 L0 to L4 dwarfs and a handful ofbr /> L5 to T1 dwarfs, providing precision of 0.1-0.3 mas in parallax for these objects, and tangential velocities at thenbsp;level of 10-30 m s-1. As these objects are very close, the perspective acceleration will change both the parallaxnbsp;and the proper motion over the time frame of the mission, leading to ldquo;astrometricrdquo; radial velocities with errorsnbsp;of 50 km s-1. However, to fully exploit the extremely accurate and precise astrometric data, it is fundamentalnbsp;to obtain better radial velocities. In this contribution we present the preliminary results from a large campaignnbsp;conducted with OSIRIS on the GTC and X-shooter on the VLT to measure radial velocities for L dwarfs that willnbsp;be observed by Gaia. The spectra will be used to determine radial velocities, spectral indices, identify possiblebr /> unresolved binaries, and further investigate the peculiar objects in the sample. Combined with the Gaia resultsnbsp;this will be a incomparable dataset for many studies./p>

  13. Cloud structure of brown dwarfs from spectroscopic variability observations

    NASA Astrophysics Data System (ADS)

    Buenzli, E.; Marley, M. S.; Apai, D.; Lupu, R. E.

    Recent discoveries of variable brown dwarfs have provided us with a new window into their three-dimensional cloud structure. The highest variables are found at the L/T transition, where the cloud cover is thought to break up, but variability has been found to occur also for both cloudy L dwarfs and (mostly) cloud-free mid T dwarfs. We summarize results from recent HST programs measuring the spectral variability of brown dwarfs in the near-infrared and compare to results from ground-based programs. We discuss the patchy cloud structure of L/T transition objects, for which it is becoming increasingly certain that the variability does not arise from cloud holes into the deep hot regions but from varying cloud thickness. We present a new patchy cloud model to explain the spectral variability of 2MASSJ21392676+0220226. We also discuss the curious multi-wavelength variability behavior of the recently discovered very nearby early T dwarf WISE J104915.57-531906.1B (Luhman 16B) and the mid T dwarf 2MASS J22282889-431026. Based on observations made with the NASA/ESA Hubble Space Telescope, obtained at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-26555. These observations are associated with program # 12314 and 13280

  14. Physical properties of orbital debris from spectroscopic observations

    NASA Astrophysics Data System (ADS)

    Jorgensen, K.; Africano, J.; Hamada, K.; Stansbery, E.; Sydney, P.; Kervin, P.

    2004-01-01

    Currently, certain physical properties, such as material type and albedo, of orbital debris are assumed when used to determine the size of the objects. A study to ascertain whether or not the assumed values are valid has begun using reflectance spectroscopy as a means of determining the material type of the object. What appears to some as a squiggly line is actually the reflectance of sunlight from the object. By comparing the location, depth, and width of the absorption features on the squiggly lines, the material type of the debris object is identified. Once the material type is known, the albedo of the object can be determined. This paper discusses the results from observations of large rocket bodies and satellites in both lower and geosynchronous Earth orbits (LEO and GEO, respectively) taken at the air force maui optical and supercomputing (AMOS) site located in Maui, Hawaii. Using the 1.6-m telescope and a spectral range of 0.3-0.9 μm, differences between rocket bodies of different types and launch dates, as well as satellites of different types and launch dates are determined. Variations seen in the squiggle lines are due to colors of paint, space weathering, and for the satellites, orientation and size of the solar panels. Future direction of the project will be discussed as well as plans for future observations.

  15. Spectroscopic Observations of Nearby Cool Stars: The DUNES Sample

    NASA Astrophysics Data System (ADS)

    Maldonado, J.; Eiroa, C.; Martínez-Arnáiz, R. M.; Montes, D.

    2010-10-01

    The detection of faint dusty exo-zodies and exo-EKBs around mature stars is a direct proof of planetesimal systems. Relating the properties of such structures with the hosting stars is fundamental to get clear clues concerning how common planetary systems are, and how the form and evolve. DUNES (DUst around NEarby Stars (see http://www.mpia-hd.mpg.de/DUNES/) is a Herschel Open Time Key Project with the aim of detecting cool faint exo-solar analogues to the Edgeworth-Kuiper Belt (EKB). Since the success of DUNES depends on very accurate determination of the stellar properties and age, we have started a high resolution observing program of the DUNES targets, with the first results are presented here.

  16. Spectroscopic observations of the detached binary PG 1413 + 015

    NASA Technical Reports Server (NTRS)

    Fulbright, Michael S.; Liebert, James; Bergeron, P.; Green, Richard

    1993-01-01

    We present improved estimates of the stellar parameters of the eclipsing, precataclysmic binary system PG 1413 + 015 (GH Vir), which has an orbital period of only 8h16m. Model atmosphere fits a Balmer line profiles yield T(eff) = 48,800 +/- 1200 K and log g = 7.70 +/- 0.11 for the DAO white dwarf primary star, from which a mass of 0.51 +/- 0.04 solar mass is inferred using evolutionary models. An ultraviolet spectrum obtained with the IUE Observatory has a slope consistent with this temperature and the assumption of no interstellar extinction. A red CCD spectrum of the secondary star during the 12-minute total eclipse indicates a spectral type of M3 V-M5 V. Reanalysis of the eclipse light curve leads to an inferred radius of 0.15 solar radius and a mass of 0.10 solar mass for the secondary, the latter being marginally consistent with the spectral type. Reprocessing on the facing side of the secondary produces phase-dependent Balmer line emission and detectable variations in the continuum from 6500-9000 A. The observed levels of reprocessing are consistent with expectations based on the above stellar parameters.

  17. Spitzer mid-infrared spectroscopic observations of planetary nebulae

    NASA Astrophysics Data System (ADS)

    Mata, H.; Ramos-Larios, G.; Guerrero, M. A.; Nigoche-Netro, A.; Toalá, J. A.; Fang, X.; Rubio, G.; Kemp, S. N.; Navarro, S. G.; Corral, L. J.

    2016-06-01

    We present Spitzer Space Telescope archival mid-infrared (mid-IR) spectroscopy of a sample of 11 planetary nebulae (PNe). The observations, acquired with the Spitzer Infrared Spectrograph (IRS), cover the spectral range 5.2-14.5 μm that includes the H2 0-0 S(2) to S(7) rotational emission lines. This wavelength coverage has allowed us to derive the Boltzmann distribution and calculate the H2 rotational excitation temperature (Tex). The derived excitation temperatures have consistent values ≃900 ± 70 K for different sources despite their different structural components. We also report the detection of mid-IR ionic lines of [Ar III], [S IV], and [Ne II] in most objects, and polycyclic aromatic hydrocarbon features in a few cases. The decline of the [Ar III]/[Ne II] line ratio with the stellar effective temperature can be explained either by a true neon enrichment or by high density circumstellar regions of PNe that presumably descend from higher mass progenitor stars.

  18. Photoelectric and Spectroscopic Observations Related to a Possible Optical Counterpart for Pulsar CP 1919+21.

    PubMed

    Lynds, R; Maran, S P; Trumbo, D E

    1968-07-05

    Spectroscopic observations of the two stars near the pulsar CP 1919+21 are not sufficiently conclusive to permit an identification of either object with the source of the radio pulses. However, our most extensive series of photometric observations of a region of sky near the radio source position, which region includes the brighter of the two stars, suggests an approximately sinusoidal variation. It is significant that the period of the variation is double the period of the radio pulsations.

  19. Optical Spectroscopic Observations of Gamma-Ray Blazar Candidates. VI. Further Observations from TNG, WHT, OAN, SOAR, and Magellan Telescopes

    NASA Astrophysics Data System (ADS)

    Álvarez Crespo, N.; Massaro, F.; Milisavljevic, D.; Landoni, M.; Chavushyan, V.; Patiño-Álvarez, V.; Masetti, N.; Jiménez-Bailón, E.; Strader, J.; Chomiuk, L.; Katagiri, H.; Kagaya, M.; Cheung, C. C.; Paggi, A.; D'Abrusco, R.; Ricci, F.; La Franca, F.; Smith, Howard A.; Tosti, G.

    2016-04-01

    Blazars, one of the most extreme classes of active galaxies, constitute so far the largest known population of γ-ray sources, and their number is continuously growing in the Fermi catalogs. However, in the latest release of the Fermi catalog there is still a large fraction of sources that are classified as blazar candidates of uncertain type (BCUs) for which optical spectroscopic observations are necessary to confirm their nature and their associations. In addition, about one-third of the γ-ray point sources listed in the Third Fermi-LAT Source Catalog (3FGL) are still unassociated and lacking an assigned lower-energy counterpart. Since 2012 we have been carrying out an optical spectroscopic campaign to observe blazar candidates to confirm their nature. In this paper, the sixth of the series, we present optical spectroscopic observations for 30 γ-ray blazar candidates from different observing programs we carried out with the Telescopio Nazionale Galileo, William Herschel Telescope, Observatorio Astronómico Nacional, Southern Astrophysical Research Telescope, and Magellan Telescopes. We found that 21 out of 30 sources investigated are BL Lac objects, while the remaining targets are classified as flat-spectrum radio quasars showing the typical broad emission lines of normal quasi-stellar objects. We conclude that our selection of γ-ray blazar candidates based on their multifrequency properties continues to be a successful way to discover potential low-energy counterparts of the Fermi unidentified gamma-ray sources and to confirm the nature of BCUs.

  20. Spectroscopic Observations of Geo-Stationary Satellites Over the Korean Peninsula

    NASA Astrophysics Data System (ADS)

    Lee, D. K.; Kim, S. J.; Han, W. Y.; Park, J. S.; Min, S. W.

    2001-11-01

    Low resolution spectroscopic observations of geo-stationary satellites over the Korean peninsula have been carried out at the KyungHee Optical Satellite Observing Facility (KOSOF) with a 40cm telescope. We have observed 9 telecommunication satellites and 1 weather satellite of 6 countries. The obtained spectral data showed that satellites could be classified and grouped with similar basic spectral feature. We divided the 10 satellites into 4 groups based on spectral slop and reflectance. It is suggested that the material types of the satellites can be determined through spectral comparisons with the ground laboratory data. We will continuously observe additional geo-stationary satellites for the accurate classification of spectral features.

  1. MASSIVE YOUNG STELLAR OBJECTS IN THE GALACTIC CENTER. I. SPECTROSCOPIC IDENTIFICATION FROM SPITZER INFRARED SPECTROGRAPH OBSERVATIONS

    SciTech Connect

    An, Deokkeun; RamIrez, Solange V.; Boogert, A. C. Adwin; Sellgren, Kris; Arendt, Richard G.; Schultheis, Mathias; Cotera, Angela S.; Stolovy, Susan R.

    2011-08-01

    We present results from our spectroscopic study, using the Infrared Spectrograph (IRS) on board the Spitzer Space Telescope, designed to identify massive young stellar objects (YSOs) in the Galactic center (GC). Our sample of 107 YSO candidates was selected based on Infrared Array Camera (IRAC) colors from the high spatial resolution, high sensitivity Spitzer/IRAC images in the Central Molecular Zone, which spans the central {approx}300 pc region of the Milky Way. We obtained IRS spectra over 5-35 {mu}m using both high- and low-resolution IRS modules. We spectroscopically identify massive YSOs by the presence of a 15.4 {mu}m shoulder on the absorption profile of 15 {mu}m CO{sub 2} ice, suggestive of CO{sub 2} ice mixed with CH{sub 3}OH ice on grains. This 15.4 {mu}m shoulder is clearly observed in 16 sources and possibly observed in an additional 19 sources. We show that nine massive YSOs also reveal molecular gas-phase absorption from CO{sub 2}, C{sub 2}H{sub 2}, and/or HCN, which traces warm and dense gas in YSOs. Our results provide the first spectroscopic census of the massive YSO population in the GC. We fit YSO models to the observed spectral energy distributions and find YSO masses of 8-23 M{sub sun}, which generally agree with the masses derived from observed radio continuum emission. We find that about 50% of photometrically identified YSOs are confirmed with our spectroscopic study. This implies a preliminary star formation rate of {approx}0.07 M{sub sun} yr{sup -1} at the GC.

  2. Massive Young Stellar Objects in the Galactic Center. 1; Spectroscopic Identification from Spitzer/IRS Observations

    NASA Technical Reports Server (NTRS)

    An, Deokkeun; Ramirez, Solange V.; Sellgren, Kris; Arendt, Richard G.; Boogert, A. C. Adwin; Robitaille, Thomas P.; Schultheis, Mathias; Cotera, Angela S.; Smith, Howard A.; Stolovy, Susan R.

    2011-01-01

    We present results from our spectroscopic study, using the Infrared Spectrograph (IRS) onboard the Spitzer Space Telescope, designed to identify massive young stellar objects (YSOs) in the Galactic Center (GC). Our sample of 107 YSO candidates was selected based on IRAC colors from the high spatial resolution, high sensitivity Spitzer/IRAC images in the Central Molecular Zone (CMZ), which spans the central approximately 300 pc region of the Milky Way Galaxy. We obtained IRS spectra over 5 micron to 35 micron using both high- and low-resolution IRS modules. We spectroscopically identify massive YSOs by the presence of a 15.4 micron shoulder on the absorption profile of 15 micron CO2 ice, suggestive of CO2 ice mixed with CH30H ice on grains. This 15.4 micron shoulder is clearly observed in 16 sources and possibly observed in an additional 19 sources. We show that 9 massive YSOs also reveal molecular gas-phase absorption from C02, C2H2, and/or HCN, which traces warm and dense gas in YSOs. Our results provide the first spectroscopic census of the massive YSO population in the GC. We fit YSO models to the observed spectral energy distributions and find YSO masses of 8 - 23 solar Mass, which generally agree with the masses derived from observed radio continuum emission. We find that about 50% of photometrically identified YSOs are confirmed with our spectroscopic study. This implies a preliminary star formation rate of approximately 0.07 solar mass/yr at the GC.

  3. OPTICAL SPECTROSCOPIC OBSERVATIONS OF GAMMA-RAY BLAZAR CANDIDATES. VI. FURTHER OBSERVATIONS FROM TNG, WHT, OAN, SOAR, AND MAGELLAN TELESCOPES

    SciTech Connect

    Álvarez Crespo, N.; Massaro, F.; Milisavljevic, D.; Paggi, A.; Smith, Howard A.; Landoni, M.; Chavushyan, V.; Patiño-Álvarez, V.; Masetti, N.; Jiménez-Bailón, E.; Strader, J.; Chomiuk, L.; Katagiri, H.; Kagaya, M.; Cheung, C. C.; D’Abrusco, R.; Ricci, F.; La Franca, F.; and others

    2016-04-15

    Blazars, one of the most extreme classes of active galaxies, constitute so far the largest known population of γ-ray sources, and their number is continuously growing in the Fermi catalogs. However, in the latest release of the Fermi catalog there is still a large fraction of sources that are classified as blazar candidates of uncertain type (BCUs) for which optical spectroscopic observations are necessary to confirm their nature and their associations. In addition, about one-third of the γ-ray point sources listed in the Third Fermi-LAT Source Catalog (3FGL) are still unassociated and lacking an assigned lower-energy counterpart. Since 2012 we have been carrying out an optical spectroscopic campaign to observe blazar candidates to confirm their nature. In this paper, the sixth of the series, we present optical spectroscopic observations for 30 γ-ray blazar candidates from different observing programs we carried out with the Telescopio Nazionale Galileo, William Herschel Telescope, Observatorio Astronómico Nacional, Southern Astrophysical Research Telescope, and Magellan Telescopes. We found that 21 out of 30 sources investigated are BL Lac objects, while the remaining targets are classified as flat-spectrum radio quasars showing the typical broad emission lines of normal quasi-stellar objects. We conclude that our selection of γ-ray blazar candidates based on their multifrequency properties continues to be a successful way to discover potential low-energy counterparts of the Fermi unidentified gamma-ray sources and to confirm the nature of BCUs.

  4. SPECTROSCOPIC OBSERVATIONS OF AN EVOLVING FLARE RIBBON SUBSTRUCTURE SUGGESTING ORIGIN IN CURRENT SHEET WAVES

    SciTech Connect

    Brannon, S. R.; Longcope, D. W.; Qiu, J.

    2015-09-01

    We present imaging and spectroscopic observations from the Interface Region Imaging Spectrograph of the evolution of the flare ribbon in the SOL2014-04-18T13:03 M-class flare event, at high spatial resolution and time cadence. These observations reveal small-scale substructure within the ribbon, which manifests as coherent quasi-periodic oscillations in both position and Doppler velocities. We consider various alternative explanations for these oscillations, including modulation of chromospheric evaporation flows. Among these, we find the best support for some form of wave localized to the coronal current sheet, such as a tearing mode or Kelvin–Helmholtz instability.

  5. Imaging and spectroscopic observations of the 9 March 2016 Total Solar Eclipse in Palangkaraya

    NASA Astrophysics Data System (ADS)

    Kholish, Abdul Majid Al; Jihad, Imanul; Taufik Andika, Irham; Puspitaningrum, Evaria; Ainy, Fathin Q.; Ramadhan, Sahlan; Ikbal Arifyanto, M.; Malasan, Hakim L.

    2016-11-01

    The March 9th 2016 total solar eclipse observation was carried out at Universitas Palangkaraya, Central Kalimantan. Time-resolved imaging of the Sun has been conducted before, after, and during totality of eclipse while optical spectroscopic observation has been carried out only at the totality. The imaging observation in white light was done to take high resolution images of solar corona. The images were taken with a DSLR camera that is attached to a refractor telescope (d=66 mm, f/5.9). Despite cloudy weather during the eclipse moments, we managed to obtain the images with lower signal-to-noise ratio, including identifiable diamond ring, prominence and coronal structure. The images were processed using standard reduction procedure to increase the signal-to-noise ratio and to enhance the corona. Then, the coronal structure is determined and compared with ultraviolet data from SOHO to analyze the correlation between visual and ultraviolet corona. The spectroscopic observation was conducted using a slit-less spectrograph and a DSLR camera to obtain solar flash spectra. The flash spectra taken during the eclipse show emissions of H 4861 Å, He I 5876 Å, and H 6563 Å. The Fe XIV 5303 Å and Fe X 6374 Å lines are hardly detected due to low signal-to-noise ratio. Spectral reduction and analysis are conducted to derive the emission lines intensity relative to continuum intensity. We use the measured parameters to determine the temperature of solar chromosphere.

  6. Spectroscopic observations of V443 Herculis - A symbiotic binary with a low mass white dwarf

    NASA Technical Reports Server (NTRS)

    Dobrzycka, Danuta; Kenyon, Scott J.; Mikolajewska, Joanna

    1993-01-01

    We present an analysis of new and existing photometric and spectroscopic observations of the symbiotic binary V443 Herculis. This binary system consists of a normal M5 giant and a hot compact star. These two objects have comparable luminosities: about 1500 solar for the M5 giant and about 1000 solar for the compact star. We identify three nebular regions in this binary: a small, highly ionized volume surrounding the hot component, a modestly ionized shell close to the red giant photosphere, and a less dense region of intermediate ionization encompassing both binary components. The system parameters for V443 Her suggest the hot component currently declines from a symbiotic nova eruption.

  7. Low X-Ray Luminosity Galaxy Clusters: Main Goals, Sample Selection, Photometric and Spectroscopic Observations

    NASA Astrophysics Data System (ADS)

    Nilo Castellón, José Luis; Alonso, M. Victoria; García Lambas, Diego; Valotto, Carlos; O'Mill, Ana Laura; Cuevas, Héctor; Carrasco, Eleazar R.; Ramírez, Amelia; Astudillo, José M.; Ramos, Felipe; Jaque Arancibia, Marcelo; Ulloa, Natalie; Órdenes, Yasna

    2016-06-01

    We present our study of 19 low X-ray luminosity galaxy clusters (L{}X ˜ 0.5-45 × 1043 erg s-1), selected from the ROSAT Position Sensitive Proportional Counters Pointed Observations and the revised version of Mullis et al. in the redshift range of 0.16-0.7. This is the introductory paper of a series presenting the sample selection, photometric and spectroscopic observations, and data reduction. Photometric data in different passbands were taken for eight galaxy clusters at Las Campanas Observatory; three clusters at Cerro Tololo Interamerican Observatory; and eight clusters at the Gemini Observatory. Spectroscopic data were collected for only four galaxy clusters using Gemini telescopes. Using the photometry, the galaxies were defined based on the star-galaxy separation taking into account photometric parameters. For each galaxy cluster, the catalogs contain the point-spread function and aperture magnitudes of galaxies within the 90% completeness limit. They are used together with structural parameters to study the galaxy morphology and to estimate photometric redshifts. With the spectroscopy, the derived galaxy velocity dispersion of our clusters ranged from 507 km s-1 for [VMF98]022 to 775 km s-1 for [VMF98]097 with signs of substructure. Cluster membership has been extensively discussed taking into account spectroscopic and photometric redshift estimates. In this sense, members are the galaxies within a projected radius of 0.75 Mpc from the X-ray emission peak and with clustercentric velocities smaller than the cluster velocity dispersion or 6000 km s-1, respectively. These results will be used in forthcoming papers to study, among the main topics, the red cluster sequence, blue cloud and green populations, the galaxy luminosity function, and cluster dynamics.

  8. Chemical Nature Of Titan’s Organic Aerosols Constrained from Spectroscopic and Mass Spectrometric Observations

    NASA Astrophysics Data System (ADS)

    Imanaka, Hiroshi; Cruikshank, D. P.

    2012-10-01

    The Cassini-Huygens observations greately extend our knowledge about Titan’s organic aerosols. The Cassini INMS and CAPS observations clearly demonstrate the formation of large organic molecules in the ionosphere [1, 2]. The VIMS and CIRS instruments have revealed spectral features of the haze covering the mid-IR and far-IR wavelengths [3, 4, 5, 6]. This study attempts to speculate the possible chemical nature of Titan’s aerosols by comparing the currently available observations with our laboratory study. We have conducted a series of cold plasma experiment to investigate the mass spectrometric and spectroscopic properties of laboratory aerosol analogs [7, 8]. Titan tholins and C2H2 plasma polymer are generated with cold plasma irradiations of N2/CH4 and C2H2, respectively. Laser desorption mass spectrum of the C2H2 plasma polymer shows a reasonable match with the CAPS positive ion mass spectrum. Furthermore, spectroscopic features of the the C2H2 plasma polymer in mid-IR and far-IR wavelegths qualitatively show reasonable match with the VIMS and CIRS observations. These results support that the C2H2 plasma polymer is a good candidate material for Titan’s aerosol particles at the altitudes sampled by the observations. We acknowledge funding supports from the NASA Cassini Data Analysis Program, NNX10AF08G, and from the NASA Exobiology Program, NNX09AM95G, and the Cassini Project. [1] Waite et al. (2007) Science 316, 870-875. [2] Crary et al. (2009) Planet. Space Sci. 57, 1847-1856. [3] Bellucci et al. (2009) Icarus 201, 198-216. [4] Anderson and Samuelson (2011) Icarus 212, 762-778. [5] Vinatier et al. (2010) Icarus 210, 852-866. [6] Vinatier et al. (2012) Icarus 219, 5-12. [7] Imanaka et al. (2004) Icarus 168, 344-366. [8] Imanaka et al. (2012) Icarus 218, 247-261.

  9. Direct spectroscopic observation of a shallow hydrogenlike donor state in insulating SrTiO3.

    PubMed

    Salman, Z; Prokscha, T; Amato, A; Morenzoni, E; Scheuermann, R; Sedlak, K; Suter, A

    2014-10-10

    We present a direct spectroscopic observation of a shallow hydrogenlike muonium state in SrTiO(3) which confirms the theoretical prediction that interstitial hydrogen may act as a shallow donor in this material. The formation of this muonium state is temperature dependent and appears below ∼ 70K. From the temperature dependence we estimate an activation energy of ∼ 50 meV in the bulk and ∼ 23 meV near the free surface. The field and directional dependence of the muonium precession frequencies further supports the shallow impurity state with a rare example of a fully anisotropic hyperfine tensor. From these measurements we determine the strength of the hyperfine interaction and propose that the muon occupies an interstitial site near the face of the oxygen octahedron in SrTiO(3). The observed shallow donor state provides new insight for tailoring the electronic and optical properties of SrTiO(3)-based oxide interface systems.

  10. High-Resolution Spectroscopic Database for the NASA Earth Observing System Program

    NASA Technical Reports Server (NTRS)

    Rothman, Laurence S.; Starr, David (Technical Monitor)

    2002-01-01

    The purpose of this project is to develop and enhance the HITRAN molecular spectroscopic database and associated software to support the observational programs of the Earth Observing System (EOS). In particular, the focus is on the EOS projects: the Atmospheric Infrared Sounder (AIRS), the High-Resolution Dynamics Limb Sounder (HIRDLS), Measurements of Pollution in the Troposphere (MOPITT), the Tropospheric Emission Spectrometer (TES), and the Stratospheric Aerosol and Gas Experiment (SAGE III). The data requirements of these programs in terms of spectroscopy are varied, but usually call for additional spectral parameters or improvements to existing molecular bands. In addition, cross-section data for heavier molecular species must be expanded and made amenable to modeling in remote sensing. The effort in the project also includes developing software and distribution to make access, manipulation, and use of HITRAN functional to the EOS program.

  11. Implementation of Multiple Spectroscopic Techniques to Simultaneously Observe Native and Mutated Protein Unfolding

    NASA Astrophysics Data System (ADS)

    Cull, Brennan; Ben, Kelty; Link, Justin

    A protein's natural, correctly folded structure can determine the protein's ability to carry out its function. If the unfolding process of proteins can be observed, then the relative stability can be better understood between native and mutated proteins. A global picture of the unfolding process may be completed through the studies of strategically mutated proteins using tryptophan as a probe. Horse heart cytochrome c, a thoroughly studied, model protein was used in our investigation to explore this idea. Various spectroscopic techniques such as circular dichroism (CD), absorbance, and fluorescence were simultaneously applied while slowly unfolding our protein by increasing the concentration of a chemical denaturant, guanidine hydrochloride. This provided us information about the thermodynamic properties of the protein and several mutants which can then be interpreted to gain relative stability information among mutations. Efforts to utilize these techniques on native and mutated proteins in comparison to current scientific unfolding theories will be presented in this session.

  12. High-dispersion infrared spectroscopic observations of comet 8P/Tuttle with VLT/CRIRES

    NASA Astrophysics Data System (ADS)

    Kobayashi, H.; Bockelée-Morvan, D.; Kawakita, H.; Dello Russo, N.; Jehin, E.; Manfroid, J.; Smette, A.; Hutsemékers, D.; Stüwe, J.; Weiler, M.; Arpigny, C.; Biver, N.; Cochran, A.; Crovisier, J.; Magain, P.; Sana, H.; Schulz, R.; Vervack, R. J.; Weaver, H.; Zucconi, J.-M.

    2010-01-01

    We report on the composition of the Halley-family comet (HFC) 8P/Tuttle investigated with high-dispersion near-infrared spectroscopic observations. The observations were carried out at the ESO VLT (Very Large Telescope) with the CRIRES instrument as part of a multi-wavelength observation campaign of 8P/Tuttle performed in late January and early February 2008. Radar observations suggested that 8P/Tuttle is a contact binary, and it was proposed that these components might be heterogeneous in chemistry. We determined mixing ratios of organic volatiles with respect to H2O and found that mixing ratios were consistent with previous near infrared spectroscopic observations obtained in late December 2007 and in late January 2008. It has been suggested that because 8P/Tuttle is a contact binary, it might be chemically heterogeneous. However, we find no evidence for chemical heterogeneity within the nucleus of 8P/Tuttle. We also compared the mixing ratios of organic molecules in 8P/Tuttle with those of both other HFCs and long period comets (LPCs) and found that HCN, C2H2, and C2H6 are depleted whereas CH4 and CH3OH have normal abundances. This may indicate that 8P/Tuttle was formed in a different region of the early solar nebula than other HFCs and LPCs. We estimated the conversion efficiency from C2H2 to C2H6 by hydrogen addition reactions on cold grains by employing the C2H6/(C2H6+C2H2) ratio. The C2H6/(C2H6+C2H2) ratio in 8P/Tuttle is consistent with the ratios found in other HFCs and LPCs within the error bars. We also discuss the source of C2 and CN based on our observations and conclude that the abundances of C2H2 and C2H6 are insufficient to explain the C2 abundances in comet 8P/Tuttle and that the abundance of HCN is insufficient to explain the CN abundances in the comet, so at least one additional parent is needed for each species, as pointed out in previous study. Based on observations collected at the European Southern Observatory, Paranal, Chile (ESO Prog. 080.C

  13. Submillimetric Spectroscopic Observations of Volatiles in Comet C-2004 Q2 (Machholz)

    NASA Technical Reports Server (NTRS)

    DeVal-Borro, M.; Hartogh, P.; Jarchow, C.; Rengel, M.; Villanueva, G. L.; Kueppers, M.; Biver, N.; Bockelee-Morvan, D.; Crovisier, J.

    2012-01-01

    Submillimeter spectroscopic observations of comets provide an important tool for understanding their chemical composition and enable a taxonomic classification. Aims. We aim to determine the production rates of several parent- and product volatiles and the C-12/C-13 isotopic carbon ratio in the long-period comet C/2004 Q2 (Machholz), which is likely to originate from the Oort Cloud. Methods. The line emission from several molecules in the coma was measured with high signal-to-noise ratio in January 2005 at heliocentric distance of 1.2 AU by means of high-resolution spectroscopic observations using the Submillimeter Telescope (SMT) at the Arizona Radio Observatory (ARO). Results. We have obtained production rates of several volatiles (CH3OH, HCN, H(sup 13)CN, HNC, H2CO, CO, and CS) by comparing the observed and simulated line-integrated intensities. We calculated the synthetic profiles using a radiative transfer code that includes collisions between neutrals and electrons, and the effects of radiative pumping of the fundamental vibrational levels by solar infrared radiation. Furthermore, multiline observations of the CH3OH J = 7-6 series allow us to estimate the rotational temperature using the rotation diagram technique. We find that the CH3OH population distribution of the levels sampled by these lines can be described by a rotational temperature of 40 +/- 3 K. Derived mixing ratios relative to hydrogen cyanide are CO/CH3OH/H2CO/CS/HNC/HC-13N/HCN= 30.9/24.6/4.8/0.57/0.031/0.013/1 assuming a pointing offset of 8" due to the uncertain ephemeris at the time of the observations and the telescope pointing error. Conclusions. The measured relative molecular abundances in C/2004 Q2 (Machholz) are between low- to typical values of those obtained in Oort Cloud comets, suggesting that it has visited the inner solar system previously and undergone thermal processing. The HNC/HCN abundance ratio of approx 3.1% is comparable to that found in other comets, accounting for the

  14. IMAGING AND SPECTROSCOPIC OBSERVATIONS OF MAGNETIC RECONNECTION AND CHROMOSPHERIC EVAPORATION IN A SOLAR FLARE

    SciTech Connect

    Tian, Hui; Reeves, Katharine K.; Raymond, John C.; Chen, Bin; Murphy, Nicholas A.; Li, Gang; Guo, Fan; Liu, Wei

    2014-12-20

    Magnetic reconnection is believed to be the dominant energy release mechanism in solar flares. The standard flare model predicts both downward and upward outflow plasmas with speeds close to the coronal Alfvén speed. Yet, spectroscopic observations of such outflows, especially the downflows, are extremely rare. With observations of the newly launched Interface Region Imaging Spectrograph (IRIS), we report the detection of a greatly redshifted (∼125 km s{sup –1} along the line of sight) Fe XXI 1354.08 Å emission line with a ∼100 km s{sup –1} nonthermal width at the reconnection site of a flare. The redshifted Fe XXI feature coincides spatially with the loop-top X-ray source observed by RHESSI. We interpret this large redshift as the signature of downward-moving reconnection outflow/hot retracting loops. Imaging observations from both IRIS and the Atmospheric Imaging Assembly (AIA) on board the Solar Dynamics Observatory also reveal the eruption and reconnection processes. Fast downward-propagating blobs along these loops are also found from cool emission lines (e.g., Si IV, O IV, C II, Mg II) and images of AIA and IRIS. Furthermore, the entire Fe XXI line is blueshifted by ∼260 km s{sup –1} at the loop footpoints, where the cool lines mentioned above all exhibit obvious redshift, a result that is consistent with the scenario of chromospheric evaporation induced by downward-propagating nonthermal electrons from the reconnection site.

  15. Revised spectroscopic parameters of SH(+) from ALMA and IRAM 30m observations.

    PubMed

    Müller, Holger S P; Goicoechea, Javier R; Cernicharo, José; Agúndez, Marcelino; Pety, Jérôme; Cuadrado, Sara; Gerin, Maryvonne; Dumas, Gaëlle; Chapillon, Edwige

    2014-09-19

    Hydrides represent the first steps of interstellar chemistry. Sulfanylium (SH(+)), in particular, is a key tracer of energetic processes. We used ALMA and the IRAM 30 m telescope to search for the lowest frequency rotational lines of SH(+) toward the Orion Bar, the prototypical photo-dissociation region illuminated by a strong UV radiation field. On the basis of previous Herschel/HIFI observations of SH(+), we expected to detect emission of the two SH(+) hyperfine structure (HFS) components of the NJ = 10-01 fine structure (FS) component near 346 GHz. While we did not observe any lines at the frequencies predicted from laboratory data, we detected two emission lines, each ~15 MHz above the SH(+) predictions and with relative intensities and HFS splitting expected for SH(+). The rest frequencies of the two newly detected lines are more compatible with the remainder of the SH(+) laboratory data than the single line measured in the laboratory near 346 GHz and previously attributed to SH(+). Therefore, we assign these new features to the two SH(+) HFS components of the NJ = 10-01 FS component and re-determine its spectroscopic parameters, which will be useful for future observations of SH(+), in particular if its lowest frequency FS components are studied. Our observations demonstrate the suitability of these lines for SH(+) searches at frequencies easily accessible from the ground.

  16. Solar Flares Observed with the Ramaty High Energy Solar Spectroscopic Imager (RHESSI)

    NASA Technical Reports Server (NTRS)

    Holman, Gordon D.

    2004-01-01

    Solar flares are impressive examples of explosive energy release in unconfined, magnetized plasma. It is generally believed that the flare energy is derived from the coronal magnetic field. However, we have not been able to establish the specific energy release mechanism(s) or the relative partitioning of the released energy between heating, particle acceleration (electrons and ions), and mass motions. NASA's RHESSI Mission was designed to study the acceleration and evolution of electrons and ions in flares by observing the X-ray and gamma-ray emissions these energetic particles produce. This is accomplished through the combination of high-resolution spectroscopy and spectroscopic imaging, including the first images of flares in gamma rays. RHESSI has observed over 12,000 solar flares since its launch on February 5, 2002. I will demonstrate how we use the RHESSI spectra to deduce physical properties of accelerated electrons and hot plasma in flares. Using images to estimate volumes, w e typically find that the total energy in accelerated electrons is comparable to that in the thermal plasma. I will also present flare observations that provide strong support for the presence of magnetic reconnection in a large-scale, vertical current sheet in the solar corona. RHESSI observations such as these are allowing us to probe more deeply into the physics of solar flares.

  17. High Resolution Spectroscopic Database for the NASA Earth Observing System Program

    NASA Technical Reports Server (NTRS)

    Rothman, Laurence

    2004-01-01

    The purpose of this project has been to develop and enhance the HITRAN molecular spectroscopic database and associated software to support the observational programs of the Earth Observing System (EOS). Emphasis has been on the EOS projects: the Atmospheric Infrared Sounder (AIRS), the High-Resolution Dynamics Limb Sounder (HIRDLS), Measurements of Pollution in the Troposphere (MOPITT), the Tropospheric Emission Spectrometer (TES), and the Stratospheric Aerosol and Gas Experiment (SAGE III). The HITRAN program is also involved in the Ozone Monitoring Experiment (OMI). The data requirements of these programs in terms of spectroscopy are varied with respect to constituents being observed, required remote-sensing parameters, and spectral coverage. A general requisite is for additional spectral parameters and improvements to existing molecular bands sufficient for the simulation of the observations leading to retrieval of the atmospheric state. In addition, cross-section data for heavier molecular species must be expanded and made amenable to modeling in remote sensing. The effort in the project also includes developing software and distribution to make access, manipulation, and use of HITRAN functional to the EOS program.

  18. High-Resolution Spectroscopic Database for the NASA Earth Observing System Program

    NASA Technical Reports Server (NTRS)

    Rothman, Laurence S.

    2004-01-01

    The purpose of this project is to develop and enhance the HITRAN molecular spectroscopic database and associated - software to support the observational programs of the Earth observing System (EOS). In particular, the focus is on the EOS projects: the Atmospheric Infrared Sounder (AIRS), the High-Resolution Dynamics Limb Sounder (HIRDLS), Measurements of Pollution in the Troposphere (MOPITT), the Tropospheric Emission Spectrometer (TES), and the Stratospheric Aerosol and Gas Experiment (SAGE III). The HITRAN program is also involved in the Ozone Monitoring Experiment (OMI). The data requirements of these programs in terms of spectroscopy are varied with respect to constituents being observed, required remote-sensing parameters, and spectral coverage. A general requisite is for additional spectral parameters and improvements to existing molecular bands sufficient for the simulation of the observations leading to retrieval of the atmospheric state. In addition cross-section data for heavier molecular species must be expanded and made amenable to modeling in remote sensing. The effort in the project also includes developing software and distribution to make access, manipulation, and use HITRAN functional to the EOS program.

  19. Far Ultraviolet Spectroscopic Explorer Observations of the Blue Compact Dwarf Galaxy Markarian 59

    NASA Astrophysics Data System (ADS)

    Thuan, Trinh X.; Lecavelier des Etangs, Alain; Izotov, Yuri I.

    2002-02-01

    New Far Ultraviolet Spectroscopic Explorer (FUSE) far-UV spectroscopy of the nearby metal-deficient (Zsolar/8) cometary blue compact dwarf (BCD) galaxy Markarian (Mrk) 59 is discussed. The data are used to investigate element abundances in its interstellar medium. The H I absorption lines are characterized by narrow cores that are interstellar in origin and by broad wings that are stellar in origin. The mean interstellar H I column density is ~7×1020 cm-2 in Mrk 59. No H2 lines are seen and N(H2) is <~1015 cm-2 at the 10 σ level. The lack of diffuse H2 is due to the combined effect of a strong UV radiation field that destroys the H2 molecules and a low metallicity that leads to a scarcity of dust grains necessary for H2 formation. P Cygni profiles of the S VI λλ933.4, 944.5 and O VI λλ1031.9, 1037.6 lines are seen, indicating the presence of very hot O stars and a stellar wind terminal velocity of ~1000 km s-1. By fitting the line profiles with multiple components having each a velocity dispersion b=7 km s-1 and spanning a radial velocity range of 100 km s-1, some of which can be saturated, we derive heavy element abundances in the neutral gas. We find logN(O I)/N(H I)=-5.0+/-0.3 or [O I/H I]=-1.5 for the neutral gas, about a factor of 10 below the oxygen abundance of the supergiant H II region, implying self-enrichment of the latter. Based on observations made with the NASA-CNES-CSA Far Ultraviolet Spectroscopic Explorer. FUSE is operated for NASA by the Johns Hopkins University under NASA contract NAS 5-32985.

  20. Comments: Statistical Analysis for Multisite Trials

    ERIC Educational Resources Information Center

    Bloom, Howard S.

    2012-01-01

    In this article, the author shares his comments on statistical analysis for multisite trials, and focuses on the contribution of Stephen Raudenbush, Sean Reardon, and Takako Nomi to future research. Raudenbush, Reardon, and Nomi provide a major contribution to future research on variation in program impacts by showing how to use multisite trials…

  1. Visible Spectroscopic Observation Of Asteroid 162173 (1999ju3) With The Gemini-s Telescope

    NASA Astrophysics Data System (ADS)

    Sugita, Seiji; Kuroda, D.; Kameda, S.; Hasegawa, S.; Kamata, S.; Abe, M.; Ishiguro, M.; Takato, N.; Yoshikawa, M.

    2012-10-01

    Asteroid 162173 (1999JU3; hereafter JU3) is the target of the Hayabusa-2 mission. Its visible reflectance spectra have been observed a few times [1,2], and obtained spectra exhibit a wide variety of spectral patterns ranging from a spectra with absorption in the UV region (May 1999) to a flat spectrum with a faint broad absorption centered around 0.6 microns (September 2007) and that with UV absorption and strong broad absorption centered around 0.7 micron (July 2007). The apparent large spectral variation may be due to variegation on the asteroid surface. Such variegation would make a large influence on remote sensing strategy for Hayabusa-2 before its sampling operations. In order to better constraint the spectral properties of JU3, we conducted visible spectroscopic observations at the GEMINI-South observatory 8.1-m telescope with the GMOS instrument. We could obtain three different sets of data in June and July 2012. Although the JU3 rotation phases of two of the observation are close to each other, the other is about 120 degrees away from the two. Our preliminary analyses indicate that these three spectra are slightly reddish but generally flat across the observed wavelength range (0.47 - 0.89 microns). The observed flat spectra are most similar to the spectrum obtained in September 2007, which probably has the highest signal-to-noise ratio among the previous three spectra. This result suggests that material with a flat spectrum probably covers a dominant proportion of the JU3 surface and that the other two types of previously obtained spectra may not cover a very large fraction of the JU3 surface. [1] Binzel, R. P. et al. (2001) Icarus, 151, 139-149; [2] Vilas, F. (2008) AJ, 135, 1101-1105.

  2. Mid-infrared Spectroscopic Observations of the Dust-forming Classical Nova V2676 Oph

    NASA Astrophysics Data System (ADS)

    Kawakita, Hideyo; Ootsubo, Takafumi; Arai, Akira; Shinnaka, Yoshiharu; Nagashima, Masayoshi

    2017-02-01

    The dust-forming nova V2676 Oph is unique in that it was the first nova to provide evidence of C2 and CN molecules during its near-maximum phase and evidence of CO molecules during its early decline phase. Observations of this nova have revealed the slow evolution of its lightcurves and have also shown low isotopic ratios of carbon (12C/13C) and nitrogen (14N/15N) in its envelope. These behaviors indicate that the white dwarf (WD) star hosting V2676 Oph is a CO-rich WD rather than an ONe-rich WD (typically larger in mass than the former). We performed mid-infrared spectroscopic and photometric observations of V2676 Oph in 2013 and 2014 (respectively 452 and 782 days after its discovery). No significant [Ne ii] emission at 12.8 μm was detected at either epoch. These provided evidence for a CO-rich WD star hosting V2676 Oph. Both carbon-rich and oxygen-rich grains were detected in addition to an unidentified infrared feature at 11.4 μm originating from polycyclic aromatic hydrocarbon molecules or hydrogenated amorphous carbon grains in the envelope of V2676 Oph. Based on data collected at the Subaru Telescope, which is operated by the National Astronomical Observatory of Japan.

  3. A SURVEY OF FAR ULTRAVIOLET SPECTROSCOPIC EXPLORER OBSERVATIONS OF CATACLYSMIC VARIABLES

    SciTech Connect

    Froning, Cynthia S.; Long, Knox S.; Gaensicke, Boris; Szkody, Paula E-mail: long@stsci.edu E-mail: szkody@alicar.astro.washington.edu

    2012-03-01

    During its lifetime, the Far Ultraviolet Spectroscopic Explorer (FUSE) was used to observe 99 cataclysmic variables (CVs) in 211 separate observations. Here, we present a survey of the moderate-resolution (R {approx_equal} 10, 000), far-ultraviolet (905-1188 A), time-averaged FUSE spectra of CVs. The FUSE spectra are morphologically diverse. They show contributions from the accretion disk, the disk chromosphere, disk outflows, and the white dwarf (WD), but the relative contribution of each component varies widely as a function of CV subtype, orbital period and evolutionary state, inclination, mass accretion rate, and magnetic field strength of the WD. The data reveal information about the structure, temperature, density and mass flow rates of the disk and disk winds, the temperature of the WD and the effects of ongoing accretion on its structure, and the long-term response of the systems to disk outbursts. The complete atlas of time-averaged FUSE spectra of CVs is available at the Multimission Archive at Space Telescope Science Institute as a High Level Science Product.

  4. Spectroscopic observations of AT2016hvu and PNV J00424181+4113433 with the Nordic Optical Telescope

    NASA Astrophysics Data System (ADS)

    Somero, A.; Kangas, T.; Harmanen, J.; Ederoclite, A.; Barcewicz, S.; Heikkila, T.; Hon, S.; Kumar, T.; Mattila, S.; Gafton, E.

    2016-11-01

    We report spectroscopic observations of the transient AT2016hvu in NGC7316 discovered by the Catalina Real-time Transient Survey (CRTS; Drake et al. 2009, ApJ, 696, 870 ; http://crts.caltech.edu/) and the nova candidate PNV J00424181+4113433 reported in ATel #9716.

  5. Spectroscopic observation of SN 2017pp by NUTS (NOT Un-biased Transient Survey)

    NASA Astrophysics Data System (ADS)

    Pastorello, A.; Elias-Rosa, N.; Benetti, S.; Cappellaro, E.; Terreran, G.; Tomasella, L.; Tronsgaard, R.

    2017-01-01

    The Nordic Optical Telescope (NOT) Unbiased Transient Survey (NUTS; ATel #8992) reports the spectroscopic classification of SN 2017pp in PGC 1378162. The candidate was discovered by F. Ciabattari, E. Mazzoni, S. Donati (ISSP; http://italiansupernovae.org).

  6. NIR SPECTROSCOPIC OBSERVATION OF MASSIVE GALAXIES IN THE PROTOCLUSTER AT z = 3.09

    SciTech Connect

    Kubo, Mariko; Yamada, Toru; Ichikawa, Takashi; Kajisawa, Masaru; Matsuda, Yuichi; Tanaka, Ichi

    2015-01-20

    We present the results of near-infrared spectroscopic observations of the K-band-selected candidate galaxies in the protocluster at z = 3.09 in the SSA22 field. We observed 67 candidates with K {sub AB} < 24 and confirmed redshifts of the 39 galaxies at 2.0 < z {sub spec} < 3.4. Of the 67 candidates, 24 are certainly protocluster members with 3.04 ≤ z {sub spec} ≤ 3.12, which are massive red galaxies that have been unidentified in previous optical observations of the SSA22 protocluster. Many distant red galaxies (J – K {sub AB} > 1.4), hyper extremely red objects (J – K {sub AB} > 2.1), Spitzer MIPS 24 μm sources, active galactic nuclei (AGNs) as well as the counterparts of Lyα blobs and the AzTEC/ASTE 1.1 mm sources in the SSA22 field are also found to be protocluster members. The mass of the SSA22 protocluster is estimated to be ∼2-5 × 10{sup 14} M {sub ☉}, and this system is plausibly a progenitor of the most massive clusters of galaxies in the current universe. The reddest (J – K {sub AB} ≥ 2.4) protocluster galaxies are massive galaxies with M {sub star} ∼ 10{sup 11} M {sub ☉} showing quiescent star formation activities and plausibly dominated by old stellar populations. Most of these massive quiescent galaxies host moderately luminous AGNs detected by X-ray. There are no significant differences in the [O III] λ5007/Hβ emission line ratios and [O III] λ5007 line widths and spatial extents of the protocluster galaxies from those of massive galaxies at z ∼ 2-3 in the general field.

  7. [In situ Raman spectroscopic observation of micro-processes of methane hydrate formation and dissociation].

    PubMed

    Liu, Chang-Ling; Ye, Yu-Guang; Meng, Qing-Guo; Lü, Wan-Jun; Wang, Fei-Fei

    2011-06-01

    Micro laser Raman spectroscopic technique was used for in situ observation of the micro-processes of methane hydrate formed and decomposed in a high pressure transparent capillary. The changes in clathrate structure of methane hydrate were investigated during these processes. The results show that, during hydrate formation, the Raman peak (2 917 cm(-1)) of methane gas gradually splits into two peaks (2 905 and 2 915 cm(-1)) representing large and small cages, respectively, suggesting that the dissolved methane molecules go into two different chemical environments. In the meantime, the hydrogen bonds interaction is strengthened because water is changing from liquid to solid state gradually. As a result, the O-H stretching vibrations of water shift to lower wavenumber. During the decomposition process of methane hydrates, the Raman peaks of the methane molecules both in the large and small cages gradually clear up, and finally turn into a single peak of methane gas. The experimental results show that laser Raman spectroscopy can accurately demonstrate some relevant information of hydrate crystal structure changes during the formation and dissociation processes of methane hydrate.

  8. Spectroscopic Observation of the Re-Entry Capsule of HAYABUSA Spacecraft

    NASA Astrophysics Data System (ADS)

    Ohnishi, Kouji; Watanabe, Jun-Ichi; Sato, Mikiya; Ohkawa, Takuya; Ebizuka, Noboru

    2011-10-01

    We performed low-resolution spectroscopic observations of the capsule of the HAYABUSA spacecraft during re-entry into the Earth's atmosphere on 2010 June 13 UT as an artificial meteor. We obtained the photometric magnitude of the HAYABUSA capsule using zeroth-order spectra. The efficiency of the zeroth-order spectra was too low for us to measure the magnitude of the capsule without any saturation at all times. The altitude at the maximal flux of the capsule was at around 56 km (13h52m19s.81 UT), which is almost similar to the case GENESIS, i.e., the maximal flux at around 55 km. We examined the change in the spectrum shape of the capsule as a function of its altitude, and investigated the emission from the shock layer and the blackbody radiation from the surface of the capsule. It is found that the shock-layer emission was dominant, and/or on the same order of the blackbody radiation at the early phase of re-entry; also, the emission from blackbody radiation was dominant during the last phase of re-entry. We measured the surface temperature of the capsule along the trajectory; during the last phase before dark flight, we found that the blackbody temperature of the capsule was 3100 ± 300 K at an altitude of around 50 km, and 2400 ± 300 K at an altitude of around 40 km.

  9. Near-Simultaneous Spectroscopic and Broadband Polarimetric Observations of Be Stars

    NASA Technical Reports Server (NTRS)

    Ghosh, K.; Iyengar, K. V. K.; Ramsey, B. D.; Austin, R. A.

    1999-01-01

    Near simultaneous optical spectroscopic (on four nights) and broadband linear continuum (B, V, R, and I bands) polarimetric (on seven nights) observations of 29 Be stars were carried out during 1993 November-December. The program Be stars displayed wavelength dependence of intrinsic polarizations with no frequency dependence of polarimetric position angles. Some of the Be stars displayed long-term polarization variability. The Be and Be-shell stars could not be distinguished from one another solely on the basis of their polarization values. Full widths at half-maximum of the H.alpha profiles and the intrinsic linear continuum polarizations are closely correlated with the projected rotational velocities of the program stars. Photospheric-absorption-corrected equivalent widths of H.alpha profiles [W(alpha)] and the radii of H.alpha-emitting or -absorbing envelopes (R(sub e) or R(sub a)) are nonlinearly correlated with the intrinsic continuum polarizations of these stars. However, W(alpha) and R(sub e) are linearly correlated. With large uncertainties, there is a trend of spectral dependence of polarization. Detailed discussion of these results is presented in this paper.

  10. Reconciling Spectroscopic Electron Temperature Measurements in the Solar Corona with In Situ Charge State Observations.

    PubMed

    Esser; Edgar

    2000-03-20

    It has been a puzzle for quite some time that spectroscopic measurements in the inner corona indicate electron temperatures far too low to produce the ion fractions observed in situ in the solar wind. In the present Letter, we show that in order to reconcile the two sets of measurements, a number of conditions have to exist in the inner corona: (1) The electron distribution function has to be Maxwellian or close to Maxwellian at the coronal base, (2) the non-Maxwellian character of the distribution has to develop rapidly as a function of height and has to reach close to interplanetary properties inside of a few solar radii, and (3) ions of different elements have to flow with significantly different speeds to separate their "freezing-in" distances sufficiently so that they can encounter different distribution functions. We choose two examples to demonstrate that these conditions are general requirements if both coronal electron temperatures and in situ ion fractions are correct. However, these two examples also show that the details of the required distribution functions are very sensitive to the exact electron temperature, density, and ion flow speed profiles in the region of the corona where the ions predominantly form.

  11. Spectroscopic Observations and Analysis of the Unusual Type Ia SN1999ac

    SciTech Connect

    Garavini, G.; Aldering, G.; Amadon, A.; Amanullah, R.; Astier,P.; Balland, C.; Blanc, G.; Conley, A.; Dahlen, T.; Deustua, S.E.; Ellis,R.; Fabbro, S.; Fadeyev, V.; Fan, X.; Folatelli, G.; Frye, B.; Gates,E.L.; Gibbons, R.; Goldhaber, G.; Goldman, B.; Goobar, A.; Groom, D.E.; Haissinski, J.; Hardin, D.; Hook, I.; Howell, D.A.; Kent, S.; Kim, A.G.; Knop, R.A.; Kowalski, M.; Kuznetsova, N.; Lee, B.C.; Lidman, C.; Mendez,J.; Miller, G.J.; Moniez, M.; Mouchet, M.; Mourao, A.; Newberg, H.; Nobili, S.; Nugent, P.E.; Pain, R.; Perdereau, O.; Perlmutter, S.; Quimby, R.; Regnault, N.; Rich, J.; Richards, G.T.; Ruiz-Lapuente, P.; Schaefer, B.E.; Schahmaneche, K.; Smith, E.; Spadafora, A.L.; Stanishev,V.; Thomas, R.C.; Walton, N.A.; Wang, L.; Wood-Vasey, W.M.

    2005-07-12

    The authors present optical spectra of the peculiar Type Ia supernova (SN Ia) 1999ac. The data extend from -15 to +42 days with respect to B-band maximum and reveal an event that is unusual in several respects. prior to B-band maximum, the spectra resemble those of SN 1999aa, a slowly declining event, but possess stronger Si II and Ca II signatures (more characteristic of a spectroscopically normal SN). Spectra after B-band maximum appear more normal. The expansion velocities inferred from the Iron lines appear to be lower than average; whereas, the expansion velocity inferred from Calcium H and K are higher than average. The expansion velocities inferred from the Iron lines appear to be lower than average; whereas, the expansion velocity inferred from Calcium H and K are higher than average. The expansion velocities inferred from Si II are among the slowest ever observed, though SN 1999ac is not particularly dim. The analysis of the parameters v{sub 10}(Si II), R(Si II), v, and {Delta}m{sub 15} further underlines the unique characteristics of SN 1999ac. They find convincing evidence of C II {lambda}6580 in the day -15 spectrum with ejection velocity v > 16,000 km s{sup -1}, but this signature disappears by day -9. This rapid evolution at early times highlights the importance of extremely early-time spectroscopy.

  12. Spectroscopic observations of the distant cluster of galaxies Abell 370 - A catalogue of 84 spectra

    NASA Astrophysics Data System (ADS)

    Soucail, G.; Mellier, Y.; Fort, B.; Cailloux, M.

    1988-06-01

    Spectroscopic and photometric data are presented on 84 objects in the field of the distant cluster of galaxies Abell 370 (z = 0.374) obtained with the multiaperture spectroscopic systems PUMA developed at the Toulouse Observatory for the CFHT and ESO. The redshift and the spectral types as well as CCD photometry in the B and R bands are given with a discussion on the accuracy of the different data and measurements.

  13. Spectroscopic Observations of a Solar Flare and the Associated Coronal Mass Ejection

    NASA Astrophysics Data System (ADS)

    Murray, S.; Tian, H.; McKillop, S.

    2013-12-01

    We used data from the EUV Imaging Spectrometer (EIS) on board Hinode to examine a coronal mass ejection and a preceding flare observed on 21 November 2012 between 15:00 and 17:00 UT. Images from the Atmospheric Imaging Assembly on the Solar Dynamics Observatory were used to align the data from EIS with specific events occurring. We analyzed spectra of a few emission lines at three locations on the flare site and one location in the erupting prominence. On the flare site, we found line profiles showing typical characteristics of chromospheric evaporation: downflows at cooler lines and upflows at hotter lines. At one particular location on the flare site, we clearly identified dominant downflows on the order of 100 km/s in lines through Fe VIII to Fe XVI. To the best of our knowledge, this is the first time that such strong high-speed downflows have been spectroscopically observed in the impulsive phase of solar flares. The profile of the Fe VIII 184.54 line reveals two peaks and we were able to use the double Gaussian fit to separate the rapid downflows of dense material from the nearly stationary coronal background emission. For the erupting prominence, we were able to analyze multiple lines, cooler and warmer, of interest using this double Gaussian fit to separate the background emission from the emission of the ejected material. Our results show that the LOS velocities of the ejected material are about 100 km/s in the lower corona. Additionally, in each region of interest, we used the ratio of the density-sensitive line pair FeXII 195/186 to determine the electron density. Our results clearly show that the coronal densities were greatly enhanced during the flare. The density of the ejected material is also much larger than the typical coronal density. This research was supported by the NSF grant for the Solar Physics REU Program at the Smithsonian Astrophysical Observatory (AGS-1263241).

  14. Vertical profiling of methane and carbon dioxide using high resolution near-infrared heterodyne spectroscopic observations

    NASA Astrophysics Data System (ADS)

    Rodin, Alexander; Klimchuk, Artem; Churbanov, Dmitry; Pereslavtseva, Anastasia; Spiridonov, Maxim; Nadezhdinskyi, Alexander

    2014-05-01

    We present new method of monitoring greenhouse gases using spectroscopic observations of solar radiation passed through the atmosphere with spectral resolution ΛvδΛ up to 108. Such a high resolution is achieved by heterodyne technique and allows to retrieve full information about spectral line shape which, in turn, is used to distinguish contribution of different atmospheric layers to the resulting absorption. Weak absorption line at 6056.5 cm-1 was selected for CO2 measurements and a quartet of lines centered at 6057 cm-1for CH4. The instrument setup includes Sun tracker with a microtelescope and chopper, diode DFB laser used as a local oscillator, a bundle of single mode optical fibers that provides medium for radiation transfer and beam coupling, reference cell with depressurized methane for LO frequency stabilization, and Fabry-Perot etalon for LO frequency calibration. A commercial p-i-n diode with squared detector replaces a mixer and IF spectrometer, providing measurement of heterodyne beating within a bandpass of few MHz, which determines the effective spectral resolution of the instrument. Spectral coverage within narrow range (about 1 cm-1) is provided by ramping the LO frequency based on feedback from the reference channel. Observations of Sun in the Moscow region have resulted for the first time in measurements of the atmospheric transmission near 1.65 μm with sub-Doppler spectral resolution. In order to retrieve vertical profiles of methane and carbon dioxide we developed the inversion algorithm implementing Tikhonov regularization approach. With measured transmission having S/N ratio of 100 or higher, the uncertainty of CH4 profile is about 10 ppb, with the uncertainty of CO2 profile at 1 ppm. This techniques is promising an affordable opportunity or widespread monitoring of greenhouse gases and may be implemented on existing ground-based stations. This work has been supported by the grant of Russian Ministry of education and science #11.G34.31.0074

  15. 2-D Spectroscopic Observations of O II Recombination Lines in the Planetary Nebula NGC 7009

    NASA Astrophysics Data System (ADS)

    Hwang, Sehyun; Dinerstein, H.; Hill, G.; MacQueen, P.; Adams, J.; Blanc, G.

    2007-12-01

    We present preliminary results from 2-D spatially-resolved spectroscopic observations of the planetary nebula NGC 7009, obtained in September 2007 on the McDonald Observatory 2.7m telescope utilizing the integral field unit (IFU) VIRUS-P (Visible Integral-field Replicable Unit Spectrograph-Prototype; Hill et al., 2006, New Astronomy Reviews, 50, 378). The instrument delivers simultaneous spectra in 247 fibers over the wavelength range 3550-5850Å at a spectral resolving power of 1000 at 5000Å. By taking three spatially dithered integrations, fully-sampled maps can be obtained for a region of 112"×112" with an angular resolution of 4.1". These observations are part of an observing program to investigate the enigma of the optical recombination lines (ORLs) such as those of O II, that appear to indicate higher oxygen abundances than the collisionally excited lines (CELs) from the same ion, in some planetary nebulae. In order to resolve this abundance discrepancy, Liu et al. (2000, MNRAS, 312, 585) proposed a dual-abundance model, which postulates that the nebulae which display this behavior contain cold, metal-rich, H-deficient inclusions where the ORLs are produced, embedded in hotter material of more normal composition from which the CELs arise. This model can provide a good fit to the integrated-light spectra, but the cold, metal-rich inclusions have yet to be spatially resolved or isolated. We have obtained fully-sampled maps of several planetary nebulae that display this anomaly, in an effort to find evidence for localized variations in the strengths of the ORLs relative to the CELs that would be expected if the cold, metal-rich gas is concentrated in spatially distinct clumps. In this poster we will present results from our observations to date, in particular from a recent VIRUS-P observing set of NGC 7009. [This research was supported by NSF grants AST-0408609/-0708245 to H.L.D., and VIRUS-P has been by the Cynthia and George Mitchell Foundation.

  16. First spectroscopic observations of the substellar companion of the young debris disk star PZ Telescopii

    NASA Astrophysics Data System (ADS)

    Schmidt, T. O. B.; Mugrauer, M.; Neuhäuser, R.; Vogt, N.; Witte, S.; Hauschildt, P. H.; Helling, Ch.; Seifahrt, A.

    2014-06-01

    Context. In 2010 a substellar companion to the solar analog pre-main sequence star PZ Tel and member of the approximately 12 Myr old β Pic moving group was found by high-contrast direct imaging independently by two teams. Aims: In order to determine the basic parameters of this companion more precisely and independent of evolutionary models, hence age-independent, we obtained follow-up spectroscopic observations of the primary and companion. Methods: We used the Spectrograph for INtegral Field Observations in the Near Infrared (SINFONI) at the Very Large Telescope Unit 4/Yepun of ESO's Paranal Observatory in the H + K band and processed the data using the spectral deconvolution technique. The resulting spectrum of the companion was then compared to a grid of Drift-Phoenix synthetic model spectra, a combination of a general-purpose model atmosphere code with a non-equilibrium, stationary cloud and dust model, using a χ2 minimization analysis. Results: We find a best fitting spectral type of G6.5 for PZ Tel A. The extracted spectrum of the substellar companion, at a spatial position compatible with earlier orbit estimates, yields a temperature Teff = 2500-115+138 K, a visual extinction AV = 0.53-0.53+0.84 mag, a surface gravity of log g = 3.50-0.30+0.51 dex, and a metallicity at the edge of the grid of [M/H] = 0.30-0.30 dex. Conclusions: We derive a luminosity of log(Lbol/L⊙) = -2.66-0.08+0.06, a radius of R = 2.42-0.34+0.28 RJup, and a mass of M = 7.5-4.3+16.9 MJup for the PZ Tel companion, which is consistent with most earlier estimates using photometry alone. Combining our results with evolutionary models, we find a best-fitting mass of about 21 Jupiter masses at an age corresponding to the recently determined lithium depletion age of 7-2+4 Myr. Hence, the PZ Tel companion is most likely a wide brown dwarf companion in the 12-4+8 Myr old β Pic moving group. Based on observations made with ESO Telescopes at the La Silla Paranal Observatory under program ID 087

  17. Simulation-optimization framework for multi-site multi-season hybrid stochastic streamflow modeling

    NASA Astrophysics Data System (ADS)

    Srivastav, Roshan; Srinivasan, K.; Sudheer, K. P.

    2016-11-01

    able to predict the characteristics of the multi-site multi-season streamflows under uncertain future. Also, the AMHMABB model is found to perform better than the linear multi-site disaggregation model (MDM) in preserving the statistical as well as the multi-site critical deficit run characteristics of the observed flows. However, a major drawback of the hybrid models persists in case of the AMHMABB model as well, of not being able to synthetically generate enough number of flows beyond the observed extreme flows, and not being able to generate values that are quite different from the observed flows.

  18. The Tarantula Massive Binary Monitoring. I. Observational campaign and OB-type spectroscopic binaries

    NASA Astrophysics Data System (ADS)

    Almeida, L. A.; Sana, H.; Taylor, W.; Barbá, R.; Bonanos, A. Z.; Crowther, P.; Damineli, A.; de Koter, A.; de Mink, S. E.; Evans, C. J.; Gieles, M.; Grin, N. J.; Hénault-Brunet, V.; Langer, N.; Lennon, D.; Lockwood, S.; Maíz Apellániz, J.; Moffat, A. F. J.; Neijssel, C.; Norman, C.; Ramírez-Agudelo, O. H.; Richardson, N. D.; Schootemeijer, A.; Shenar, T.; Soszyński, I.; Tramper, F.; Vink, J. S.

    2017-02-01

    Context. Massive binaries play a crucial role in the Universe. Knowing the distributions of their orbital parameters is important for a wide range of topics from stellar feedback to binary evolution channels and from the distribution of supernova types to gravitational wave progenitors, yet no direct measurements exist outside the Milky Way. Aims: The Tarantula Massive Binary Monitoring project was designed to help fill this gap by obtaining multi-epoch radial velocity (RV) monitoring of 102 massive binaries in the 30 Doradus region. Methods: In this paper we analyze 32 FLAMES/GIRAFFE observations of 93 O- and 7 B-type binaries. We performed a Fourier analysis and obtained orbital solutions for 82 systems: 51 single-lined (SB1) and 31 double-lined (SB2) spectroscopic binaries. Results: Overall, the binary fraction and orbital properties across the 30 Doradus region are found to be similar to existing Galactic samples. This indicates that within these domains environmental effects are of second order in shaping the properties of massive binary systems. A small difference is found in the distribution of orbital periods, which is slightly flatter (in log space) in 30 Doradus than in the Galaxy, although this may be compatible within error estimates and differences in the fitting methodology. Also, orbital periods in 30 Doradus can be as short as 1.1 d, somewhat shorter than seen in Galactic samples. Equal mass binaries (q> 0.95) in 30 Doradus are all found outside NGC 2070, the central association that surrounds R136a, the very young and massive cluster at 30 Doradus's core. Most of the differences, albeit small, are compatible with expectations from binary evolution. One outstanding exception, however, is the fact that earlier spectral types (O2-O7) tend to have shorter orbital periods than later spectral types (O9.2-O9.7). Conclusions: Our results point to a relative universality of the incidence rate of massive binaries and their orbital properties in the

  19. Synergies between spectroscopic and time-series photometric surveys - LAMOST observations for the Kepler field and K2 fields

    NASA Astrophysics Data System (ADS)

    Fu, Jianning; De Cat, Peter; Smith, Martin

    2017-01-01

    Synergies between spectroscopic and time-series photometric surveys can provide valuable information for studies in Galactic archaeology. The Kepler satellite has provided unprecedented high duty-cycle, high-precision time-series photometric observations for a large number of stars. After a continuous monitoring of the Kepler field for 4 years, it started to observe K2 fields, which include multiple stellar populations, for about 80 days each. These observed fields are all good targets for Galactic archaeology, provided that spectroscopic observations can be made for hundreds of thousands of stars within these fields in a homogeneous way.In 2010, we initiated the LAMOST-Kepler project with the aim to collect low-resolution spectra for as many objects from the KIC10 catalogue as possible with the Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST). This is a 4-m telescope equipped with 4,000 optical fibers covering a circular field of view with a diameter of 5 degrees on the sky. The observations since 2012 have resulted in 150,567 low-resolution spectra with the Signal-Noise-Ratio in r larger than 20. The stellar atmospheric parameters were derived and calibrated with the values determined from either high-resolution spectroscopy or asteroseismology. Since the end of 2015, five K2 fields have been observed with LAMOST and the qualified spectra were used to derive the stellar atmospheric parameters for 59,213 stars.In this presentation we introduce the LAMOST-Kepler project, whose data have a great potential for Galactic archaeology. It includes an update on the progress and a summary of the existing scientific works based on the data provided by this project.

  20. Spectroscopic observation of simultaneous bi-directional reconnection outflows in a laboratory plasma

    NASA Astrophysics Data System (ADS)

    Brown, M. R.; Cothran, C. D.; Gray, T.; Myers, C. E.; Belova, E. V.

    2012-08-01

    We report a precise, direct spectroscopic measurement of simultaneous bi-directional outflows from a reconnection event in a laboratory plasma. Outflow speeds are as Alfvénic and Abel analysis shows that the outflows are generated in the plasma core. A Sweet-Parker like analysis of outflow speed coupled with external measurements of reconnection electric field and assumption of Spitzer resistivity predict an aspect ratio of the reconnection layer and reconnection rate that are close to that measured in the experiment and in simulations. However, this analysis underestimates the absolute scale of the layer, indicating other than 2D resistive physics is at play.

  1. How Can Multi-Site Evaluations Be Participatory?

    ERIC Educational Resources Information Center

    Lawrenz, Frances; Huffman, Douglas

    2003-01-01

    Multi-site evaluations are becoming increasingly common in federal funding portfolios. Although much thought has been given to multi-site evaluation, there has been little emphasis on how it might interact with participatory evaluation. Therefore, this paper reviews several National Science Foundation educational, multi-site evaluations for the…

  2. Photometric and Spectroscopic Observations of SN 2012dn, a Super-Chandra Candidate Type-Ia Supernova

    NASA Astrophysics Data System (ADS)

    Parrent, Jerod T.; Transient Factory, Palomar; Cumbres Observatory Global Telescope Network, Las

    2013-01-01

    Currently, there is no singular standard model picture of type-Ia supernovae (SNe Ia) with a parameter-space of predictions that overlap the observed, diverse array of SN Ia properties. The same can be said for the super-luminous versions of SNe Ia, those thought to originate from up to 2.4 solar mass progenitor systems. To make matters worse, we remain in the dark-ages of astronomy regarding the interpretation of their observed spectra. In short, line-blending due to resonant line-scattering alone prevents making clear the compositional makeup of the outermost ejected layers. Since simulations of violent merger and single degenerate scenarios are both able to roughly reproduce spectroscopic observations, the direct mapping of the ejecta via spectrum synthesis measurements is of high importance. For example, with the closest SN Ia to date, SN 2011fe, we were able to map (in velocity space) the composition of the outer layers of ejecta. We did this by evolving simple P-Cygni-blends of synthetic spectra over the course of the first month (post-explosion), with an average of 1.8 days between observations by which to compare. As a result, SN 2011fe gave a clearer picture of the compositional structure of a ''normal'' SN Ia. We now have another chance to put this measure of SN Ia diversity into practice with the discovery of a brighter than normal southern hemisphere object, SN 2012dn. Here we present g-, r-, and i-band photometric observations obtained at Faulkes Telescope South, as well as optical time-series spectra from Gemini-North, Gemini-South, SALT, and MMT facilities. With 19 spectroscopic observations spanning its first month, post-explosion, we are able to measure the relative velocities of the periodic table in the outermost layers of ejected material. This serves as a means for distinguishing the origin of SNe Ia and their various forms.

  3. Near Infrared photometric and spectroscopic observations of the bright optical transient J212444.87+321738.3

    NASA Astrophysics Data System (ADS)

    Mondal, Soumen; Das, Ramkrishna; Ashok, N. M.; Banerjee, D. P. K.; Dutta, Somnath; Ghosh, Supriyo; Mondal, Anindita

    2013-04-01

    We report near infrared JHK-band photometry and spectroscopic observations of the recently reported bright optical transient J212444.87+321738.3 using the Near-IR Imager cum spectrograph (NICMOS-3) installed on the Mount Abu 1.2-m telescope of the Physical Research Laboratory, India following the outburst announcement by Tiurina et al. in ATel #4888. The photometric observations were carried out on 2013 March 21.020 UT and 23.010 UT yielding magnitudes of J = 5.85 +/- 0.06, H = 4.47 +/- 0.06, K = 3.77 +/- 0.05; and J= 5.64 +/- 0.04, H= 4.48 +/- 0.04, K = 3.77 +/- 0.03 respectively.

  4. Thermal treatment effects imposed on solid DNA cationic lipid complex with hexadecyltrimethylammonium chloride, observed by variable angle spectroscopic ellipsometry

    SciTech Connect

    Nizioł, Jacek

    2014-12-21

    DNA cationic lipid complexes are materials of properties required for applications in organic electronics and optoelectronics. Often, their thermal stability demonstrated by thermogravimetry is cited in the literature as important issue. However, little is known about processes occurring in heated solid DNA cationic lipid complexes. In frame of this work, thin films of Deoxyribonucleic acid-hexadecyltrimethylammonium chloride (DNA-CTMA) were deposited on silicon wafers. Samples were thermally annealed, and simultaneously, their optical functions were measured by spectroscopic ellipsometry. At lower temperatures, thermal expansion coefficient of solid DNA-CTMA was negative, but at higher temperatures positive. Thermally induced modification of absorption spectrum in UV-vis was observed. It occurred at a range of temperatures higher than this of DNA denaturation in solution. The observed phenomenon was irreversible, at least in time scale of the experiment (one day)

  5. Culture and Influence in Multisite Evaluation

    ERIC Educational Resources Information Center

    Kirkhart, Karen E.

    2011-01-01

    Understanding the influence of multisite evaluation requires careful consideration of cultural context. The author illustrates dimensions of influence and culture with excerpts from four National Science Foundation evaluation case studies and summarizes what influence teaches everyone about culture and what culture teaches everyone about…

  6. The OmegaWhite survey for short-period variable stars - III: follow-up photometric and spectroscopic observations

    NASA Astrophysics Data System (ADS)

    Macfarlane, S. A.; Woudt, P. A.; Groot, P. J.; Ramsay, G.; Toma, R.; Motsoaledi, M.; Crause, L. A.; Gilbank, D. G.; O'Donoghue, D.; Potter, S. B.; Sickafoose, A. A.; van Gend, C.; Worters, H. L.

    2017-02-01

    We present photometric and spectroscopic follow-up observations of short-period variables discovered in the OmegaWhite survey, a wide-field high-cadence g-band synoptic survey targeting the Galactic Plane. We have used fast photometry on the SAAO 1.0- and 1.9-m telescopes to obtain light curves of 27 variables, and use these results to validate the period and amplitude estimates from the OmegaWhite processing pipeline. Furthermore, 57 sources (44 unique, 13 with new light curves) were selected for spectroscopic follow-up using either the SAAO 1.9-m telescope or the Southern African Large Telescope. We find that many of these variables have spectra which are consistent with being δ Scuti-type pulsating stars. At higher amplitudes, we detect four possible pulsating white dwarf/subdwarf sources and an eclipsing cataclysmic variable. Due to their rarity, these targets are ideal candidates for detailed follow-up studies. From spectroscopy, we confirm the symbiotic binary star nature of two variables identified as such in the SIMBAD database. We also report what could possibly be the first detection of the `Bump Cepheid' phenomena in a δ Scuti star, with OW J175848.21-271653.7 showing a pronounced 22 per cent amplitude dip lasting 3 min during each pulsational cycle peak. However, the precise nature of this target is still uncertain as it exhibits the spectral features of a B-type star.

  7. Bias and Bias Correction in Multi-Site Instrumental Variables Analysis of Heterogeneous Mediator Effects

    ERIC Educational Resources Information Center

    Reardon, Sean F.; Unlu, Faith; Zhu, Pei; Bloom, Howard

    2013-01-01

    We explore the use of instrumental variables (IV) analysis with a multi-site randomized trial to estimate the effect of a mediating variable on an outcome in cases where it can be assumed that the observed mediator is the only mechanism linking treatment assignment to outcomes, as assumption known in the instrumental variables literature as the…

  8. Bias and Bias Correction in Multisite Instrumental Variables Analysis of Heterogeneous Mediator Effects

    ERIC Educational Resources Information Center

    Reardon, Sean F.; Unlu, Fatih; Zhu, Pei; Bloom, Howard S.

    2014-01-01

    We explore the use of instrumental variables (IV) analysis with a multisite randomized trial to estimate the effect of a mediating variable on an outcome in cases where it can be assumed that the observed mediator is the only mechanism linking treatment assignment to outcomes, an assumption known in the IV literature as the exclusion restriction.…

  9. Optical Spectroscopic Observations of γ-Ray Blazar Candidates. III. The 2013/2014 Campaign in the Southern Hemisphere

    NASA Astrophysics Data System (ADS)

    Landoni, M.; Massaro, F.; Paggi, A.; D'Abrusco, R.; Milisavljevic, D.; Masetti, N.; Smith, H. A.; Tosti, G.; Chomiuk, L.; Strader, J.; Cheung, C. C.

    2015-05-01

    We report the results of our exploratory program carried out with the southern Astrophysical Research telescope aimed at associating counterparts and establishing the nature of the Fermi Unidentified γ-ray Sources (UGSs). We selected the optical counterparts of six UGSs from the Fermi catalog on the basis of our recently discovered tight connection between infrared and γ-ray emission found for the γ-ray blazars detected by the Wide-Field Infrared Survey Explorer in its all-sky survey. We perform for the first time a spectroscopic study of the low-energy counterparts of the Fermi UGSs, in the optical band, confirming the blazar-like nature of the whole sample. We also present new spectroscopic observations of six active galaxies of uncertain type associated with Fermi sources which appear to be BL Lac objects. Finally, we report the spectra collected for six known γ-ray blazars belonging to the Roma BZCAT that were obtained to establish their nature or better estimate their redshifts. Two interesting cases of high redshift and extremely luminous BL Lac objects (z ≥ 1.18 and z ≥ 1.02, based on the detection of Mg ii intervening systems) are also discussed. Based on observations obtained at the southern Astrophysical Research (SOAR) telescope, which is a joint project of the Ministério da Ciência, Tecnologia, e Inovação (MCTI) da República Federativa do Brasil, the U.S. National Optical Astronomy Observatory (NOAO), the University of North Carolina at Chapel Hill (UNC), and Michigan State University (MSU).

  10. Detection of High-Frequency Oscillations and Damping from Multi-slit Spectroscopic Observations of the Corona

    NASA Astrophysics Data System (ADS)

    Samanta, T.; Singh, J.; Sindhuja, G.; Banerjee, D.

    2016-01-01

    During the total solar eclipse of 11 July 2010, multi-slit spectroscopic observations of the solar corona were performed from Easter Island, Chile. To search for high-frequency waves, observations were taken at a high cadence in the green line at 5303 Å that is due to [Fe xiv] and the red line at 6374 Å that is due to [Fe x]. The data were analyzed to study the periodic variations in intensity, Doppler velocity, and line width using wavelet analysis. The data with high spectral and temporal resolution enabled us to study the rapid dynamical changes within coronal structures. We find that at certain locations, each parameter shows significant oscillation with periods ranging from 6 - 25 s. For the first time, we were able to detect damping of high-frequency oscillations with periods of about 10 s. If the observed damped oscillations are due to magnetohydrodynamic waves, then they can contribute significantly to the heating of the corona. From a statistical study we try to characterize the nature of the observed oscillations while considering the distribution of power in different line parameters.

  11. An Overview of Ultraviolet Through Infrared Reflectance Spectroscopic Observations of Mercury During the First MESSENGER Flyby

    NASA Astrophysics Data System (ADS)

    Izenberg, N. R.; McClintock, W. E.; Holsclaw, G. M.; Robinson, M. S.; Blewett, D. T.; Domingue, D. L.; Head, J. W.; Jensen, E. A.; Kochte, M. C.; Lankton, M. R.; Murchie, S. L.; Sprague, A. L.; Vilas, F.; Solomon, S. C.

    2008-05-01

    During the first MESSENGER flyby of Mercury on January 14, 2008, the Mercury Atmospheric and Surface Composition Spectrometer (MASCS) measured reflectance spectra from Mercury's surface over the wavelength range 220-1450 nm. These are the first high-spatial-resolution (<10 km) spectra at any wavelength and the first reported ultraviolet (UV, wavelength < 360 nm) observations of the surface. MASCS observed the sunlit surface for approximately 14 minutes after closest approach, acquiring over 650 spectra with the Visible and Infrared Spectrograph (VIRS) detectors of MASCS sensitive to wavelengths of 350-1450 nm. MASCS also obtained just under four grating scans in the middle ultraviolet (220-320 nm) using MASCS's Ultraviolet and Visible Spectrometer (UVVS) component. Most of the near-equatorial ground track of the observation covered terrain in the previously unseen hemisphere of Mercury but also crossed into the hemisphere viewed by Mariner 10 south of Mozart crater and in Tir Planitia. Ground-based observations of Mercury reveal a surface with a red, nearly featureless spectrum in the visible and near-infrared (wavelengths greater than ~ 500 nm) that has been interpreted as evidence for a largely iron-poor feldspathic composition. Initial analyses of VIRS spectra also show strongly red-sloped, near featureless spectra, appearing to support contentions of low iron abundance in surface materials. However, interpretation of Mercury's spectral reflectance is complicated by our lack of knowledge about the effects on its surface materials of space weathering, which both suppresses the strength of spectral absorption features and reddens the spectrum. Brightness variations and absorption bands in ultraviolet reflectance may help determine both the nature and extent of processes that modify observed reflectance at longer wavelengths. MASCS surface observation data demonstrate spectral variations across the Mercury surface that can be related to previous telescopic

  12. Multi-site, multivariate weather generator using maximum entropy bootstrap

    NASA Astrophysics Data System (ADS)

    Srivastav, Roshan K.; Simonovic, Slobodan P.

    2014-05-01

    Weather generators are increasingly becoming viable alternate models to assess the effects of future climate change scenarios on water resources systems. In this study, a new multisite, multivariate maximum entropy bootstrap weather generator (MEBWG) is proposed for generating daily weather variables, which has the ability to mimic both, spatial and temporal dependence structure in addition to other historical statistics. The maximum entropy bootstrap (MEB) involves two main steps: (1) random sampling from the empirical cumulative distribution function with endpoints selected to allow limited extrapolation and (2) reordering of the random series to respect the rank ordering of the original time series (temporal dependence structure). To capture the multi-collinear structure between the weather variables and between the sites, we combine orthogonal linear transformation with MEB. Daily weather data, which include precipitation, maximum temperature and minimum temperature from 27 years of record from the Upper Thames River Basin in Ontario, Canada, are used to analyze the ability of MEBWG based weather generator. Results indicate that the statistics from the synthetic replicates were not significantly different from the observed data and the model is able to preserve the 27 CLIMDEX indices very well. The MEBWG model shows better performance in terms of extrapolation and computational efficiency when compared to multisite, multivariate K-nearest neighbour model.

  13. Time Series Spectroscopic and Photometric Observations of the Massive DAV BPM 37093

    NASA Astrophysics Data System (ADS)

    Nitta, Atsuko; Kepler, S. O.; Chene, Andre–Nicolas; Koester, D.; Provencal, J. L.; Sullivan, D. J.; Chote, Paul; Safeko, Ramotholo; Kanaan, Antonio; Romero, Alejandra; Corti, Mariela; Corti, Mariela; Kilic, Mukremin; Winget, D. E.

    2015-06-01

    BPM 37093 was the first of only a handful of massive (1.05+/-0.05 M⊙; Bergeron 2004;Koester & Allard 2000) white dwarf pulsators discovered (Kanaan et al. 1992). These stars are particularly interesting because the crystallized mass-fraction as a function of mass and temperature is poorly constrained by observation, yet this process adds 1-2 Gyr uncertainty in ages of the oldest white dwarf stars observed and hence, in the ages of associations that contain them (Abrikosov 1960; Kirzhnits 1960; Salpeter 1961). Last year, we discovered that ESO uses BPM 37093 as a standard star and extracted corresponding spectra from the public archive. The data suggested a large variation in the observed hydrogen line profiles that could potentially be due to pulsations, but the measurement did not reach a detection-quality threshold. To further explore this possibility, though, we obtained 4hrs of continuous time series spectroscopy of BPM 37093 with Gemini in the Northern Spring of 2014. We present our preliminary results from these data along with those from the accompanying time series photometric observations we gathered from Mt. John (New Zealand), South African Astronomical Observatory (SAAO), Panchromatic Robotic optical Monitoring and Polarimetry Telescopes (PROMPT) in Chile, and Complejo Astronomico El Leoncito (Argentina) to support the Gemini observations.

  14. Direct Spectroscopic Observation of the Structural Origin of Peroxide Generation from Co-Based Pyrolyzed Porphyrins for ORR Applications

    SciTech Connect

    Ziegelbauer,J.; Olson, T.; Pylypenko, S.; Alamgir, F.; Jaye, C.; Atanassov, P.; Mukerjee, S.

    2008-01-01

    Pyrolyzed transition metal based porphyrins present an attractive alternative to state of the art Pt-based electrocatalysts for fuel cell applications based on their comparatively low cost. Unfortunately, the large array of precursors and synthetic strategies has led to considerable ambiguity regarding the specific structure/property relationships that give rise to their activity for oxygen reduction. Specifically, considerable debate exists in actual chemical structure of the pyrolyzed reaction centers, and their relationship to membrane-damaging peroxide yield. In this manuscript a comprehensive electrochemical and spectroscopic study of pyrolyzed CoTMPP produced via a self-templating process is presented. The resulting electrocatalysts are not carbon-supported, but are highly porous self-supported pyropolymers. Rotating ring disk electrode measurements showed that the materials pyrolyzed at 700 C exhibited the highest performance, whereas pyrolysis at 800 C resulted in a significant increase in the peroxide yield. X-ray photoelectron spectroscopy and Co L and K edge extended X-ray absorption fine structure (EXAFS) studies confirm that the majority of the Co-N4 active site has broken down to Co-N2 at 800 C. Application of ?{mu} analysis (an X-ray absorption near-edge structure difference technique) to the in situ Co K edge EXAFS data allowed for direct spectroscopic observation of the geometry of Oads on the pyropolymer active sites. The specific geometrical adsorption of molecular oxygen with respect to the plane of the Co-Nx moieties highly influences the oxygen reduction reaction pathway. The application of the ?{mu} technique to other transition metal based macrocycle electrocatalyst systems is expected to provide similarly detailed information.

  15. Special configuration of a very large Schmidt telescope for extensive astronomical spectroscopic observation.

    PubMed

    Wang, S G; Su, D Q; Chu, Y Q; Cui, X; Wang, Y N

    1996-09-01

    A special reflecting Schmidt telescope is used to observe celestial objects. The telescope has an aperture of 4m, f ratio of 5, and a 5° field of view. Its optical axis is fixed and tilted 25° to the horizontal that runs from south to north. The celestial objects were observed for 1.5 h as they passed through the meridian. The shape of the reflecting Schmidt plate has to be changed with each different declination δ and in the tracking process. This is achieved with active optics. The sky area to be observed is -10° ≤ δ ≤ +90°. There are plans to place ~4000 optical fibers on the telescope focal surface that will lead to a dozen spectrographs.

  16. Analysis Concerning the Inspection Threshold for Multi-Site Damage

    DTIC Science & Technology

    1993-12-01

    uL 200 words) Periodic inspections, at a prescribed interval, for Multi-Site Damage (MSD) in longitudinal fuselage lap-joints start when the aircraft ...at a prescribed interval, for Multi-Site Damage (MSD) in longitudinal fuselage lap-joints start when the aircraft has accumulated a certain number of...viii 1. INTRODUCTION AND SCOPE The cumulative probability of detection of Multi-Site Damage (MSD) in fuselage lap-joints of aging aircraft was assessed

  17. Advanced techniques for high resolution spectroscopic observations of cosmic gamma-ray sources

    NASA Technical Reports Server (NTRS)

    Matteson, J. L.; Pelling, M. R.; Peterson, L. E.; Lin, R. P.; Anderson, K. A.; Pehl, R. H.; Hurley, K. C.; Vedrenne, G.; Sniel, M.; Durouchoux, P.

    1985-01-01

    An advanced gamma-ray spectrometer that is currently in development is described. It will obtain a sensitivity of 0.0001 ph/sq cm./sec in a 6 hour balloon observation and uses innovative techniques for background reduction and source imaging.

  18. Spectroscopic observations of the Uranus' satellite Miranda in Near-IR

    NASA Astrophysics Data System (ADS)

    Gourgeot, F.; Dumas, C.; Merlin, F.; Vernazza, P.; Alvarez-Candal, A.

    2013-09-01

    We present new Near-IR spectra of the Uranus' icy satellite Miranda. This body is probably the most remarkable of all satellites of Uranus, displaying series of surface features such as faults, craters and largescale upwelling, remnant of a geologically very active past. The observations were performed first at the Palomar Observatory with the PHARO instrument (Palomar High Angular Resolution Observer) and then at the Mauna Kea Observatory with SpeX instrument based on the IRTF (Infra-Red Telescope Facility). Water ice is clearly visible in K-band (large 2.0 μm absorption band) and crystalline water ice (at 1.65 μm) seems to cover the most part of the satellite's surface. We focused the study in H band on the 1.42-1.72 μm range at observations dates corresponding to the leading and trailing hemispheres of Miranda. Contrary to the other outer Uranus' moons (Grundy et al. 2006), we did not found any significative differences between both hemispheres in this spectral range. We also studied the possible presence of volatiles like ammonia hydrate and do not exclude the possible presence of a tiny 2.22 μm band yet observed by Bauer et al. 2002. No significant features of carbon dioxide were identified on any spectra. We performed spectral models, based on bi-hemispherical reflectance theory (Hapke 1993) in order to obtain more details on the chemical compounds possibly present on the surface of this Uranian satellite.

  19. Spectroscopic Observation of Comet P/de Vico: Comparison with P/Halley and P/Brorsen-Metcalf

    NASA Astrophysics Data System (ADS)

    Kawakita, Hideyo; Ayani, Kazuya; Matsubara, Keiji

    1998-06-01

    A spectroscopic observation of Comet P/de Vico in the visible region was made at Bisei Astronomical Observatory on 1995 October 11. The obtained spectrum covers the wavelengths from 5200 to 7200 Angstroms, and includes several emissions, such as C_2, NH_2, and [O I]. The ratios of the gas-production rates of C_2 and NH_2 relative to that of H_2O, Q(C_2)/Q(H_2O), and Q(NH_2)/Q(H_2O), were determined from our observation based on the Haser model. The production-rate ratio and gas-to-dust ratio were: Q(C_2)/Q(H_2O) = 0.25%, Q(NH_2)/Q(H_2O) = 0.14%, and log_ {10}[ Q(H_2O)/Af rho ] = 26.9 at the time of observation. Comet P/de Vico was similar to P/Halley from the viewpoint of the chemical composition (C_2 and NH_2 relative to the H_2O), and P/de Vico was comparable to P/Brorsen-Metcalf concerning the gas-to-dust ratio. P/de Vico was one of the most gas-rich comets ever known.

  20. Inferential monitoring of chlorinated solvents through Raman spectroscopic observation of the vibrational modes of water.

    PubMed

    Sinfield, Joseph V; Monwuba, Chike

    2016-02-01

    Recent improvements in diode laser, fiber optic, and data acquisition technology have rejuvenated interest in field applications of Raman spectroscopy in a wide range of settings. One such application involves the observation of chlorinated solvents to facilitate the practice of "monitored natural attenuation." In this context, this manuscript focuses on means to improve the sensitivity of in-situ Raman analysis of chlorinated solvents. In particular, the work explores the performance limits of a Time-Resolved Raman Spectroscopy (TRRS) system employed to observe chlorinated solvents in aqueous samples via laboratory tests conducted on both liquid standards of trichloroethylene (TCE) and simulated biodegraded field samples. Quantitative assessment of TCE in solution is carried out through both direct observation of TCE Raman functional groups (381 cm(-1) (δ skeletal), 840 cm(-1) (νCCl) and 1242 cm(-1) (δCH)) and indirect observation of the broad OH stretching (2700-3800 cm(-1)) Raman modes of water. Results from tests on simple solutions show that the TRRS system can detect TCE at aqueous concentrations as low as 70 ppm by directly monitoring the 381 cm(-1) TCE line, whereas observation of the OH stretching line of water (3393 cm(-1)) provides an indirect indication of TCE presence with nearly a 9× improvement in detection level. This unique and counterintuitive mechanism to detect the presence of chlorinated compounds in solution takes advantage of the influence of chlorine on the vibrational modes of water. This influence, which is believed to be attributed to the formation of hydrogen bonds and their resultant interactions with the solvation shell, may serve as a more sensitive and robust indication of the presence of aggregate chlorinated solvent contamination in aqueous systems. Tests performed on simulated biodegraded field samples demonstrate that the indirect detection mechanism is apparent even in complex samples representative of typical field

  1. Non-LTE Inversion of Spectropolarimetric and Spectroscopic Observations of a Small Active-region Filament Observed at the VTT

    NASA Astrophysics Data System (ADS)

    Schwartz, P.; Balthasar, H.; Kuckein, C.; Koza, J.; Gömöry, P.; Rybák, J.; Kučera, A.; Heinzel, P.

    2016-04-01

    An active region mini-filament was observed by VTT simultaneously in the HeI 10 830 Å triplet by the TIP 1 spectropolarimeter, in Hα by the TESOS Fabry-Pérot interferometer, and in Ca II 8542 Å by the VTT spectrograph. The spectropolarimetric data were inverted using the HAZEL code and Hα profiles were modelled solving a NLTE radiative transfer in a simple isobaric and isothermal 2D slab irradiated both from bottom and sides. It was found that the mini-filament is composed of horizontal fluxtubes, along which the cool plasma of T˜10 000 K can flow by very large - even supersonic - velocities.

  2. Evidence for CO in Jupiter's atmosphere from airborne spectroscopic observations at 5 microns

    NASA Technical Reports Server (NTRS)

    Larson, H. P.; Fink, U.; Treffers, R. R.

    1978-01-01

    High-altitude (12.4 km) spectra of Jupiter recorded at the Kuiper Airborne Observatory are analyzed for the presence of CO absorption lines. A line-by-line comparison of Jupiter's spectrum with that of carbon monoxide is presented, as well as a correlation analysis that includes the influence of other gases present in Jupiter's atmosphere (CH4, NH3, H2O, PH3, and GeH4). The resulting evidence points strongly to the presence of carbon monoxide in Jupiter's atmosphere, thus strengthening Beer's evidence for it. Possible explanations for the existence and observability of Jovian CO, including convection from hotter, deeper layers or decomposition of organic molecules, are explored. A recent suggestion that the Jovian CO is restricted to stratospheric levels is not supported by the observations.

  3. Spectroscopic observations of the extended corona during the SOHO whole sun month

    NASA Technical Reports Server (NTRS)

    Strachan, L.; Raymond, J. C.; Panasyuk, A. V.; Fineschi, S.; Gardner, L. D.; Antonucci, E.; Giordano, S.; Romoli, M.; Noci, G.; Kohl, J. L.

    1997-01-01

    The spatial distribution of plasma parameters in the extended corona, derived from the ultraviolet coronagraph spectrometer (UVCS) onboard the Solar and Heliospheric Observatory (SOHO), was investigated. The observations were carried out during the SOHO whole month campaign. Daily coronal scans in the H I Lyman alpha and O VI lambda-lambda 1032 A and 1037 A were used. Maps of outflow velocities of O(5+), based on Doppler dimming of the O VI lines, are discussed. The velocity distribution widths of O(5+) are shown to be a clear signature of coronal holes while the velocity distributions for H(0) show a much smaller effect. The possible physical explanations for some of the observed features are discussed.

  4. Preliminary results of the solar corona spectroscopic observation of 9th March 2016 Total Solar Eclipse

    NASA Astrophysics Data System (ADS)

    Sungging Mumpuni, Emanuel; Zamzam Nurzaman, Muhamad; Suryana, Nana

    2016-11-01

    Spectroscopy observation of solar corona has been carried out from 9th March 2016 Total Solar Eclipse expedition in Maba, East Halmahera. Due to limitation by the weather condition during the observation, the obtained data were not favorable. Because of the low signal to noise ratio, the wavelength calibration was not straightforward. To obtain the optimum results, steps for data reduction were performed as the following: selecting the finest data, extracting the 1D spectrum from 2D spectrum, and calibrating spectrum wavelength (including careful interpolation). In this preliminary result, we discuss the instrumentation, the data under investigation, the extraction process of spectrum, and the polynomial interpolation that has been used for extracting information from our data.

  5. Spectroscopic observations of the displacement dynamics of physically adsorbed molecules-CO on C60

    NASA Astrophysics Data System (ADS)

    Yuan, Chunqing; Yates, John T.

    2016-10-01

    In this paper, we observed physically adsorbed CO molecules on C60 surface being displaced by impinging noble gas atoms (He, Ne, Ar, Kr), either through a dynamic displacement process or an exothermic replacement process, depending on their adsorption energies. This displacement mechanism could shift from one to the other depending on the surface coverage and temperature. Furthermore, rotational energy of the impinging molecules may also contribute to the dynamic displacement process by supplying additional energy.

  6. SPECTROSCOPIC OBSERVATIONS OF PLANETARY NEBULAE IN THE NORTHERN SPUR OF M31

    SciTech Connect

    Fang, X.; Liu, X.-W.; Zhang, Y.; Garcia-Benito, R.

    2013-09-10

    We present spectroscopy of three planetary nebulae (PNe) in the Northern Spur of the Andromeda galaxy (M31) obtained with the Double Spectrograph on the 5.1 m Hale Telescope at the Palomar Observatory. The samples were selected from the observations of Merrett et al. Our purpose is to investigate the formation of the substructures of M31 using PNe as a tracer of chemical abundances. The [O III] {lambda}4363 line is detected in the spectra of two objects, enabling temperature determinations. Ionic abundances are derived from the observed collisionally excited lines, and elemental abundances of nitrogen, oxygen, neon, sulfur, and argon are estimated. We study the correlations between oxygen and the {alpha}-element abundance ratios using our sample and the M31 disk and bulge PNe from the literature. In one of the three PNe, we observed a relatively higher oxygen abundance compared to the disk sample of M31 at similar galactocentric distances. The results of at least one of the three Northern Spur PNe might be in line with the proposed possible origin of the Northern Spur substructure of M31, i.e., the Northern Spur is connected to the Southern Stream and both substructures comprise the tidal debris of the satellite galaxies of M31.

  7. Impact of Spectroscopic Line Parameters on Carbon Monoxide Column Density Retrievals from Shortwave Infrared Nadir Observations

    NASA Astrophysics Data System (ADS)

    Schmidt, Denise; Gimeno Garcia, Sebastian; Schreier, Franz; Lichtenberg, Gunter

    2015-11-01

    Among the various input data required for the retrieval of atmospheric state parameters from infrared remote sensing observations molecular spectroscopy line data have a central role, because their quality is critical for the quality of the final product. Here we discuss the impact of the line parameters on vertical column densities (VCD) estimated from short wave infrared nadir observations. Using BIRRA (the Beer InfraRed Retrieval Algorithm) comprising a line-by-line radiative transfer code (forward model) and a separable nonlinear least squares solver for inversion we retrieve carbon monoxide from observations of SCIAMACHY aboard Envisat. Retrievals using recent versions of HITRAN und GEISA have been performed and the results are compared in terms of residual norms, molecular density scaling factors, their corresponding errors, and the final VCD product. The retrievals turn out to be quite similar for all three databases, so a definite recommendation in favor of one of these databases is difficult for the considered spectral range around 2.3 μm. Nevertheless, HITRAN 2012 appears to be advantageous when evaluating the different quality criteria.

  8. Spectroscopic observations of winds on Venus. I - Technique and data reduction

    NASA Technical Reports Server (NTRS)

    Young, A. T.; Crisp, D.; Barker, E. S.; Schorn, R. A.; Young, L. D. G.

    1979-01-01

    Methods of measurement and reduction of high-dispersion photographic spectra of Venus are presented. Preliminary results are consistent with slow direct or no rotation at the level sample, and disagree strongly with a 4-day retrograde rotation. A serious systematic error, which affects much published work, is due to blending of solar lines in the sky with those reflected from the planet. This always tends to produce a spurious retrograde 'rotation'. Only data obtained in a dark sky, or daytime observations from which the sky lines have been accurately subtracted, can be relied upon. All such data give low wind speeds.

  9. The FUor Candidate V582 Aurigae: First Photometric and Spectroscopic Observations

    NASA Astrophysics Data System (ADS)

    Semkov, Evgeni H.; Peneva, Stoyanka P.; Dennefeld, Michel

    One of the most attractive events in the pre-main sequence evolution is the FU Orionis (FUor) outburst. Because only a small number of FUor stars have been detected to date, photometric and spectral studies of every new object are of great interest. Recently, a new FUor candidate was discovered by Anton Khruslov - V582 Aur. To confirm the FUors nature of this object we started regular photometric observations with the telescopes of the National Astronomical Observatory Rozhen (Bulgaria). A high-resolution spectrum of V582 Aur was obtained with the 1.93 m telescope in Haute-Provence Observatory (France).

  10. Future prospects for spectroscopic and direct work - Optical and UV. [astronomical observations with Space Telescope

    NASA Technical Reports Server (NTRS)

    Burbidge, E. M.

    1978-01-01

    A description of the main features and proposed instrumentation of the 2.4 m Space Telescope is given. Highlights of work that can be planned on active nuclei of galaxies, QSOs, and BL Lac objects are briefly outlined, involving spectroscopy over wavelengths from 1200 A to 1 mm, direct imaging with 0.1 sec resolution, and the capability for 0.1 sec resolution along the spectrograph slit. The resolution, the much reduced sky background, and the full wavelength coverage also make possible important observations relevant to cosmology.

  11. In Situ Spectroscopic Observation of Activation and Transformation of Tantalum Suboxides

    SciTech Connect

    Wang, Ke; Liu, Zhi; Cruz, Tirma Herranz; Salmeron, Miquel; Liang, Hong

    2009-12-16

    Using ambient pressure X-ray Photoelectron Spectroscopy (AP-XPS), we were able to observe the process of oxidation of tantalum with different morphological parameters. Being able to trace surface evolution during oxidation, we evaluated activation energy of oxidation under the influence of strain and grain boundaries. It was found that the metal oxidized through three different stages and there was a transition stage where the phase transformation from suboxides to the equilibrium state of pentoxide. The applied stress and surface defects reduced the activation energy oxidation.

  12. Probing the IRC+10 ° 216 circumstellar envelope using spectroscopic observations of background stars

    NASA Astrophysics Data System (ADS)

    Kendall, Tim; Mauron, Nicolas; McCombie, June; Sarre, Peter

    2004-02-01

    A unique and novel set of observations has been undertaken to study the circumstellar envelope (CSE) of the nearby (130 pc) carbon star IRC +10° 216 using optical absorption spectroscopy towards twobackground stars lying beyond the envelope.The primary aim of the observations is to search for diffuse band (DIB)carriers in the CSE. The circumstellar H+2H2column density expected along the line of sight towards the targets islarge compared to that derived from the small interstellar reddening inthis region, E B-V< 0.03 mag. We summarise our mainfindings, already reported in Kendall et al. (2002): The 6284Å DIB is detected in the VLT/UVES spectrum of one target, but clearly arises inthe foreground ISM. No other DIB is seen. Hence the DIB carriers, if present in the CSE, have a low abundance relative to H in the C-rich envelope of IRC +10°216, in comparison with this ratio in theISM. An important new result, previously unreported, concerns the detectionof circumstellar C2 via absorption of the Phillips bandnear 8760Å.

  13. A Photometric and Spectroscopic Study of 3 Vulpeculae: An Observer's Nightmare

    NASA Astrophysics Data System (ADS)

    Dukes, Robert J., Jr.; Kubinec, William R.; Kubinec, Angela; Adelman, Saul J.

    2003-07-01

    We describe photometry of 3 Vulpeculae obtained with the Four College Automated Photoelectric Telescope and spectroscopy obtained with the 1.22 m telescope of the Dominion Astrophysical Observatory. We have analyzed differential uvby photometric observations obtained over 7 yr. Three main frequencies (f1=0.9719, f2=0.7923, and f3=0.8553 cycles day-1) were found, as well as a sum frequency (f1+f2=1.76420 cycles day-1). A study of the photographic region using high-dispersion spectrograms obtained with a Reticon detector at the coudé spectrograph confirms the variable nature of 3 Vul as a 53 Persei star and indicates that the star's abundances are normal for main-sequence band B stars. The new spectra were combined with those previously published to confirm an orbital period very close to 1 yr. Finally, comparison with models yielded both a mass (4.16 Msolar) and an age (25 Myr), and a mass range for the companion (0.6-1.1 Msolar). With an orbital period of almost 1 yr and a pulsation period of almost 1 day, this star is indeed an observer's nightmare.

  14. Imaging and spectroscopic observations of a filament channel and the implications for the nature of counter-streamings

    SciTech Connect

    Chen, P. F.; Fang, C.; Harra, L. K.

    2014-03-20

    The dynamics of a filament channel are observed with imaging and spectroscopic telescopes before and during the filament eruption on 2011 January 29. The extreme ultraviolet (EUV) spectral observations reveal that there are no EUV counterparts of the Hα counter-streamings in the filament channel, implying that the ubiquitous Hα counter-streamings found by previous research are mainly due to longitudinal oscillations of filament threads, which are not in phase between each other. However, there exist larger-scale patchy counter-streamings in EUV along the filament channel from one polarity to the other, implying that there is another component of unidirectional flow (in the range of ±10 km s{sup –1}) inside each filament thread in addition to the implied longitudinal oscillation. Our results suggest that the flow direction of the larger-scale patchy counter-streaming plasma in the EUV is related to the intensity of the plage or active network, with the upflows being located at brighter areas of the plage and downflows at the weaker areas. We propose a new method to determine the chirality of an erupting filament on the basis of the skewness of the conjugate filament drainage sites. This method suggests that the right-skewed drainage corresponds to sinistral chirality, whereas the left-skewed drainage corresponds to dextral chirality.

  15. Spatially resolved optical and ultrastructural properties of colorectal and pancreatic field carcinogenesis observed by inverse spectroscopic optical coherence tomography

    PubMed Central

    Yi, Ji; Radosevich, Andrew J.; Stypula-Cyrus, Yolanda; Mutyal, Nikhil N.; Azarin, Samira Michelle; Horcher, Elizabeth; Goldberg, Michael J.; Bianchi, Laura K.; Bajaj, Shailesh; Roy, Hemant K.; Backman, Vadim

    2014-01-01

    Abstract. Field carcinogenesis is the initial stage of cancer progression. Understanding field carcinogenesis is valuable for both cancer biology and clinical medicine. Here, we used inverse spectroscopic optical coherence tomography to study colorectal cancer (CRC) and pancreatic cancer (PC) field carcinogenesis. Depth-resolved optical and ultrastructural properties of the mucosa were quantified from histologically normal rectal biopsies from patients with and without colon adenomas (n=85) as well as from histologically normal peri-ampullary duodenal biopsies from patients with and without PC (n=22). Changes in the epithelium and stroma in CRC field carcinogenesis were separately quantified. In both compartments, optical and ultra-structural alterations were consistent. Optical alterations included lower backscattering (μb) and reduced scattering (μs′) coefficients and higher anisotropy factor g. Ultrastructurally pronounced alterations were observed at length scales up to ∼450  nm, with the shape of the mass density correlation function having a higher shape factor D, thus implying a shift to larger length scales. Similar alterations were found in the PC field carcinogenesis despite the difference in genetic pathways and etiologies. We further verified that the chromatin clumping in epithelial cells and collagen cross-linking caused D to increase in vitro and could be among the mechanisms responsible for the observed changes in epithelium and stroma, respectively. PMID:24643530

  16. Ultrafast spectroscopy and computational study of the photochemistry of diphenylphosphoryl azide: direct spectroscopic observation of a singlet phosphorylnitrene.

    PubMed

    Vyas, Shubham; Muthukrishnan, Sivaramakrishnan; Kubicki, Jacek; McCulla, Ryan D; Burdzinski, Gotard; Sliwa, Michel; Platz, Matthew S; Hadad, Christopher M

    2010-12-01

    The photochemistry of diphenylphosphoryl azide was studied by femtosecond transient absorption spectroscopy, by chemical analysis of light-induced reaction products, and by RI-CC2/TZVP and TD-B3LYP/TZVP computational methods. Theoretical methods predicted two possible mechanisms for singlet diphenylphosphorylnitrene formation from the photoexcited phosphoryl azide. (i) Energy transfer from the (π,π*) singlet excited state, localized on a phenyl ring, to the azide moiety, thereby leading to the formation of the singlet excited azide, which subsequently loses molecular nitrogen to form the singlet diphenylphosphorylnitrene. (ii) Direct irradiation of the azide moiety to form an excited singlet state of the azide, which in turn loses molecular nitrogen to form the singlet diphenylphosphorylnitrene. Two transient species were observed upon ultrafast photolysis (260 nm) of diphenylphosphoryl azide. The first transient absorption, centered at 430 nm (lifetime (τ) ∼ 28 ps), was assigned to a (π,π*) singlet S(1) excited state localized on a phenyl ring, and the second transient observed at 525 nm (τ ∼ 480 ps) was assigned to singlet diphenylphosphorylnitrene. Experimental and computational results obtained from the study of diphenyl phosphoramidate, along with the results obtained with diphenylphosphoryl azide, supported the mechanism of energy transfer from the singlet excited phenyl ring to the azide moiety, followed by nitrogen extrusion to form the singlet phosphorylnitrene. Ultrafast time-resolved studies performed on diphenylphosphoryl azide with the singlet nitrene quencher, tris(trimethylsilyl)silane, confirmed the spectroscopic assignment of singlet diphenylphosphorylnitrene to the 525 nm absorption band.

  17. BAT AGN Spectroscopic Survey - III. An observed link between AGN Eddington ratio and narrow-emission-line ratios

    NASA Astrophysics Data System (ADS)

    Oh, Kyuseok; Schawinski, Kevin; Koss, Michael; Trakhtenbrot, Benny; Lamperti, Isabella; Ricci, Claudio; Mushotzky, Richard; Veilleux, Sylvain; Berney, Simon; Crenshaw, D. Michael; Gehrels, Neil; Harrison, Fiona; Masetti, Nicola; Soto, Kurt T.; Stern, Daniel; Treister, Ezequiel; Ueda, Yoshihiro

    2017-01-01

    We investigate the observed relationship between black hole mass (MBH), bolometric luminosity (Lbol) and Eddington ratio (λEdd) with optical emission-line ratios ([N II] λ6583/Hα, [S II] λλ6716, 6731/Hα, [O I] λ6300/Hα, [O III] λ5007/Hβ, [Ne III] λ3869/Hβ and He II λ4686/Hβ) of hard X-ray-selected active galactic nuclei (AGN) from the BAT AGN Spectroscopic Survey. We show that the [N II] λ6583/Hα ratio exhibits a significant correlation with λEdd (RPear = -0.44, p-value = 3 × 10-13, σ = 0.28 dex), and the correlation is not solely driven by MBH or Lbol. The observed correlation between [N II] λ6583/Hα ratio and MBH is stronger than the correlation with Lbol, but both are weaker than the λEdd correlation. This implies that the large-scale narrow lines of AGN host galaxies carry information about the accretion state of the AGN central engine. We propose that [N II] λ6583/Hα is a useful indicator of Eddington ratio with 0.6 dex of rms scatter, and that it can be used to measure λEdd and thus MBH from the measured Lbol, even for high-redshift obscured AGN. We briefly discuss possible physical mechanisms behind this correlation, such as the mass-metallicity relation, X-ray heating, and radiatively driven outflows.

  18. The "Cool Algol" BD+05 706 : Photometric observations of a new eclipsing double-lined spectroscopic binary

    NASA Astrophysics Data System (ADS)

    Marschall, L. A.; Torres, G.; Neuhauser, R.

    1998-05-01

    BVRI Observations of the star BD+05 706, carried out between January, 1997, and April 1998 using the 0.4m reflector and Photometrics CCD camera at the Gettysburg College Observatory, show that the star is an eclipsing binary system with a light curve characteristic of a class of semi-detached binaries known as the "cool Algols". These results are in good agreement with the previous report of BD+05 706 as a cool Algol by Torres, Neuhauser, and Wichmann,(Astron. J., 115, May 1998) who based their classification on the strong X-ray emission detected by Rosat and on a series of spectroscopic observations of the radial velocities of both components of the system obtained at the Oak Ridge Observatory, the Fred L. Whipple Observatory, and the Multiple Mirror Telescope. Only 10 other examples of cool Algols are known, and the current photometric light curve, together with the radial velocity curves obtained previously, allows us to derive a complete solution for the physical parameters of each component, providing important constraints on models for these interesting systems.

  19. Probing the Impact of Stellar Duplicity on Planet Occurrence with Spectroscopic and Imaging Observations

    NASA Astrophysics Data System (ADS)

    Eggenberger, Anne; Udry, Stéphane

    Over the past 14 years, Doppler spectroscopy has been very successful in detecting and characterizing extrasolar planets, providing us with a wealth of information on these distant worlds (e.g., Marcy et al. 2005a; Udry and Santos 2007b; Udry et al. 2007a). One important and considerably unexpected fact these new data have taught us is that diversity is the rule in the planetary world. Diversity is found not only in the characteristics and orbital properties of the ˜ 340 planets detected thus far,1 but also in the types of environments in which they reside and are able to form. This observation has prompted a serious revision of the theories of planet formation (e.g., Lissauer and Stevenson 2007; Durisen et al. 2007; Nagasawa et al. 2007), leading to the idea that planet formation may be a richer and more robust process than originally thought.

  20. Spectroscopic observation of jet-cooled 2,5-dichlorobenzyl radical generated by corona discharge

    NASA Astrophysics Data System (ADS)

    Yi, Eun Hye; Yoon, Young Wook; Lee, Sang Kuk

    2014-07-01

    Vibronically excited but jet-cooled 2,5-dichlorobenzyl radical was generated from 2,5-dichlorotoluene precursor in a large excess of helium carrier gas, from which the visible vibronic emission spectrum was recorded. From an analysis of the spectrum observed, it was found that the origin band shows larger shift to red than those expected from mono-substitutions, which has been discussed in terms of orientation of substituents. Also, the electronic energy of the D1 → D0 transition and vibrational mode frequencies at the ground electronic state of the 2,5-dichlorobenzyl radical were determined in comparison with the known vibrational data of precursor and ab initio calculations.

  1. New spectroscopic and polarimetric observations of the A0 supergiant HD 92207

    NASA Astrophysics Data System (ADS)

    Hubrig, S.; Kholtygin, A. F.; Schöller, M.; Anderson, R. I.; Saesen, S.; González, J. F.; Ilyin, I.; Briquet, M.

    2015-02-01

    Our recent search for the presence of a magnetic field in the bright early A-type supergiant HD 92207 using FORS 2 in spectropolarimetric mode revealed the presence of a longitudinal magnetic field of the order of a few hundred Gauss. However, the definite confirmation of the magnetic nature of this object remained pending due to the detection of short-term spectral variability probably affecting the position of line profiles in left- and right-hand polarized spectra. We present new magnetic field measurements of HD 92207 obtained on three different epochs in 2013 and 2014 using FORS 2 in spectropolarimetric mode. A 3σ detection of the mean longitudinal magnetic field using the entire spectrum, _all=104±34 G, was achieved in observations obtained in 2014 January. At this epoch, the position of the spectral lines appeared stable. Our analysis of spectral line shapes recorded in opposite circularly polarized light, i.e. in light with opposite sense of rotation, reveals that line profiles in the light polarized in a certain direction appear slightly split. The mechanism causing such a behaviour in the circularly polarized light is currently unknown. Trying to settle the issue of short-term variability, we searched for changes in the spectral line profiles on a time scale of 8-10 min using HARPS polarimetric spectra and on a time scale of 3-4 min using time series obtained with the CORALIE spectrograph. No significant variability was detected on these time scales during the epochs studied. Based on observations collected with the CORALIE echelle spectrograph mounted on the 1.2-m Swiss telescope at La Silla Observatory, data obtained at the European Southern Observatory (ESO Prg. 092.D-0209(A), and data obtained from the ESO Science Archive Facility under request MSCHOELLER 102067).

  2. Extreme-Ultraviolet Spectroscopic Observation of Direct Coronal Heating During a C-Class Solar Flare

    NASA Technical Reports Server (NTRS)

    Brosius, Jeffrey W.

    2012-01-01

    With the Coronal Diagnostic Spectrometer operating in rapid cadence (9.8 s) stare mode during a C6.6 flare on the solar disk, we observed a sudden brightening of Fe xix line emission (formed at temperature T ˜ 8 MK) above the pre-flare noise without a corresponding brightening of emission from ions formed at lower temperatures, including He i (0.01 MK), Ov (0.25 MK), and Si xii (2 MK). The sudden brightening persisted as a plateau of Fe xix intensity that endured more than 11 minutes. The Fe xix emission at the rise and during the life of the plateau showed no evidence of significant bulk velocity flows, and hence cannot be attributed to chromospheric evaporation. However, the line width showed a significant broadening at the rise of the plateau, corresponding to nonthermal velocities of at least 89 km s-1 due to reconnection outflows or turbulence. During the plateau He i, Ov, and Si xii brightened at successively later times starting about 3.5 minutes after Fe xix, which suggests that these brightenings were produced by thermal conduction from the plasma that produced the Fe xix line emission; however, we cannot rule out the possibility that they were produced by a weak beam of nonthermal particles. We interpret an observed shortening of the Ov wavelength for about 1.5 minutes toward the middle of the plateau to indicate new upward motions driven by the flare, as occurs during gentle chromospheric evaporation; relative to a quiescent interval shortly before the flare, the Ov upward velocity was around -10 km s-1.

  3. Spectroscopic Coronal Observations During the Total Solar Eclipse of 11 July 2010

    NASA Astrophysics Data System (ADS)

    Voulgaris, A. G.; Gaintatzis, P. S.; Seiradakis, J. H.; Pasachoff, J. M.; Economou, T. E.

    2012-05-01

    The flash spectra of the solar chromosphere and corona were measured with a slitless spectrograph before, after, and during the totality of the solar eclipse of 11 July 2010, at Easter Island, Chile. This eclipse took place at the beginning of Solar Cycle 24, after an extended minimum of solar activity. The spectra taken during the eclipse show a different intensity ratio of the red and green coronal lines compared with those taken during the total solar eclipse of 1 August 2008, which took place toward the end of Solar Cycle 23. The characteristic coronal emission line of forbidden Fe xiv (5303 Å) was observed on the east and west solar limbs in four areas relatively symmetrically located with respect to the solar rotation axis. Subtraction of the continuum flash-spectrum background led to the identification of several extremely weak emission lines, including forbidden Ca xv (5694 Å), which is normally detected only in regions of very high excitation, e.g., during flares or above large sunspots. The height of the chromosphere was measured spectrophotometrically, using spectral lines from light elements and compared with the equivalent height of the lower chromosphere measured using spectral lines from heavy elements.

  4. Spectroscopic observation of helium-ion- and hydrogen-catalyzed hydrino transitions

    NASA Astrophysics Data System (ADS)

    Mills, Randell L.; Lu, Ying; Akhtar, Kamran

    2010-06-01

    Four predictions of Mills’ Grand Unified Theory of Classical Physics (GUTCP) regarding atomic hydrogen undergoing a catalytic reaction with certain atomized elements and ions which resonantly, nonradiatively accept integer multiples of the potential energy of atomic hydrogen, m · 27.2 eV wherein m is an integer, have been confirmed experimentally. Specifically, a catalyst comprises a chemical or physical process with an enthalpy change equal to an integer multiple m of the potential energy of atomic hydrogen, 27.2 eV. For He+ m = 2, due to its ionization reaction to He2+, and two H atoms formed from H2 by collision with a third, hot H can also act as a catalyst with m = 2 for this third H. The product is H(1/ p), fractional Rydberg states of atomic hydrogen called “hydrino atoms” wherein n = 1/2, 1/3, 1/4, …, 1/ p( p≤137 is an integer) replaces the well-known parameter n = integer in the Rydberg equation for hydrogen excited states. The predictions for the hydrino reaction of (1) pumping of the catalyst excited states, (2) characteristic EUV continuum radiation, (3) fast H, and (4) hydrino products were observed in multiple catalyst-hydrogen plasma systems.

  5. Spectroscopic observation of helium-ion- and hydrogen-catalyzed hydrino transitions

    NASA Astrophysics Data System (ADS)

    Mills, Randell; Lu, Ying; Akhtar, Kamran

    2010-06-01

    Four predictions of Mills' Grand Unified Theory of Classical Physics (GUTCP) regarding atomic hydrogen undergoing a catalytic reaction with certain atomized elements and ions which resonantly, nonradiatively accept integer multiples of the potential energy of atomic hydrogen, m · 27.2 eV wherein m is an integer, have been confirmed experimentally. Specifically, a catalyst comprises a chemical or physical process with an enthalpy change equal to an integer multiple m of the potential energy of atomic hydrogen, 27.2 eV. For He+ m = 2, due to its ionization reaction to He2+, and two H atoms formed from H2 by collision with a third, hot H can also act as a catalyst with m = 2 for this third H. The product is H(1/p), fractional Rydberg states of atomic hydrogen called "hydrino atoms" wherein n = 1/2, 1/3, 1/4, …, 1/p(p≤137 is an integer) replaces the well-known parameter n = integer in the Rydberg equation for hydrogen excited states. The predictions for the hydrino reaction of (1) pumping of the catalyst excited states, (2) characteristic EUV continuum radiation, (3) fast H, and (4) hydrino products were observed in multiple catalyst-hydrogen plasma systems.

  6. High-Dispersion Spectroscopic Observations of Comet C/2012 S1 (ISON) with the Subaru Telescope

    NASA Astrophysics Data System (ADS)

    Shinnaka, Yoshiharu; Kawakita, Hideyo; Nagashima, Masayoshi; Hitomi, Kobayashi; Decock, Alice; Jehin, Emmanuel; Boice, Daniel C.

    2014-11-01

    Comet C/2012 S1 (ISON) was one of the Oort cloud comets and dynamically new. This comet was broken at its perihelion passage on UT 2013 November 28.1 (at Rh ~ 17 solar radius). We observed the comet C/2012 S1 (ISON) on UT 2013 November 15 with the High Dispersion Spectrograph (HDS) mounted on the Subaru Telescope atop Mauna Kea, Hawaii. Its heliocentric and geocentric distances were 0.601 and 0.898 AU, respectively. We selected the slit size of 0”.5 x 9”.0 on the sky to achieve the spectral resolution of R = 72,000 from 550 to 830 nm. The total exposure time of comet C/2012 S1 (ISON) was 1200 seconds. We detected many emission lines caused from radicals (e.g., CN, C2, NH2), ions (H2O+), atoms ([OI] and Na I) and also many unidentified lines in the spectra. We report the (1) the ortho-to-para abundance ratios (OPRs) of water and ammonia estimated from the high-dispersion spectra of H2O+ and NH2, (2) the green-to-red line ratio of forbidden oxygen emissions, (3) the isotopic ratios of C2 (the carbon isotopic ratio from Swan band) and CN (the carbon and nitrogen isotopic ratios from red band), (4) the sodium-to-continuum ratio of comet C/2012 S1 (ISON).

  7. X-Ray Spectroscopic Observations with ASCA and BeppoSAX

    NASA Astrophysics Data System (ADS)

    Kaastra, J. S.

    Introduction X-ray spectroscopy The ASCA and BeppoSAX missions The most prominent spectral features observable with ASCA and - BeppoSAX A Few Notes on Spectral Data Fitting Introduction Data binning Model binning Calibration uncertainties Spectral deconvolution Statistics Low count rates Data presentation Plasma models Stellar Coronae Introduction Differential emission measure distribution techniques Temperature structure Abundances Flares Stellar evolution Hot Stars Introduction Normal O and B stars Luminous blue variables Wolf-Rayet stars Protostars and T Tauri Stars Introduction X-ray emission from protostars X-ray emission from T Tauri stars Cataclysmic Variables Introduction Non-magnetic cataclysmic variables Intermediate polars Polars High-Mass X-Ray Binaries Introduction Vela X-1 Cyg X-3 Cen X-3 SS 433 Other cases Low-Mass X-Ray Binaries Introduction 4U 1626-67 Cir X-1 Supernova Remnants Introduction Oxygen-ricg remnats: Cas A Young type Ia remnants Old shell-like remnants Synchrotron X-ray emission from SNRs Crab-like remnants Center-filled thermal remnants Jets interacting with SNRs Isolated pulsars The Magellanic Cloud SNRs Supernova explosions in distant galaxies Extended X-Ray Emission from Normal Galaxies The galactic ridge The galactic center X-ray emission from other normal galaxies Seyfert 1 Galaxies The iron line Warm absorbers The power law component Soft components Low-luminosity AGN Broad-line radio galaxies Seyfert 2 Galaxies Introduction NGC 1068 NGC 6552 NGC 4945 NGC 1808 Other cases Intermediate cases: narrow-line emission galaxies and others Quasars Radio-quiet quasars Radio-loud quasars Type 2 quasars BL Lac objects Clusters of Galaxies Temperature distribtuion of the hot medium The cooling flow and the central temperature distribtuion Mass distribution Groups of galaxies Cluster mergers and dynamical evolution Optical-depth effects The quest for the Hubble constant Abundances in nearby clusters Abundances in distant clusters Abundances

  8. Spectroscopic observation of AT2016iyw and AT2016jal by NUTS (NOT Un-biased Transient Survey)

    NASA Astrophysics Data System (ADS)

    Taddia, F.; Lundqvist, P.; Ergon, M.; Kangas, T.; Mattila, S.; Kuncarayakti, H.; Harmanen, J.; Somero, A.; Reynolds, T.; Stritzinger, M.; Dong, S.; Blay, P.

    2017-01-01

    The Nordic Optical Telescope (NOT) Unbiased Transient Survey (NUTS; ATel #8992) reports the spectroscopic classification of two transients. The candidates were discovered by the ATLAS survey (Tonry et al., ATel #9685).

  9. Nitrogen Isotopic Ratio of Cometary Ammonia from High-resolution Optical Spectroscopic Observations of C/2014 Q2 (Lovejoy)

    NASA Astrophysics Data System (ADS)

    Shinnaka, Yoshiharu; Kawakita, Hideyo

    2016-11-01

    The icy materials present in comets provide clues to the origin and evolution of our solar system and planetary systems. High-resolution optical spectroscopic observations of comet C/2014 Q2 (Lovejoy) were performed on 2015 January 11 (at 1.321 au pre-perihelion) with the High Dispersion Spectrograph mounted on the Subaru Telescope on Maunakea, Hawaii. We derive the 14N/15N ratio of NH2 (126 ± 25), as well as the ortho-to-para abundance ratios (OPRs) of the H2O+ ion (2.77 ± 0.24) and NH2 (3.38 ± 0.07), which correspond to nuclear spin temperatures of >24 K (3σ lower limit) and 27 ± 2 K, respectively. We also derive the intensity ratio of the green-to-red doublet of forbidden oxygen lines (0.107 ± 0.007). The ammonia in the comet must have formed under low-temperature conditions at ˜10 K or less to reproduce the observed 14N/15N ratio in this molecule if it is assumed that the 15N-fractionation of ammonia occurred via ion-molecule chemical reactions. However, this temperature is inconsistent with the nuclear spin temperatures of water and ammonia estimated from the OPRs. The interpretation of the nuclear spin temperature as the temperature at molecular formation may therefore be incorrect. An isotope-selective photodissociation of molecular nitrogen by protosolar ultraviolet radiation might play an important role in the 15N-fractionation observed in cometary volatiles.

  10. Spectroscopic observation of Lyα emitters at z ∼ 7.7 and implications on re-ionization

    SciTech Connect

    Faisst, A. L.; Carollo, C. M.; Capak, P.; Scarlata, C.; Scoville, N.

    2014-06-10

    We present spectroscopic follow-up observations on two bright Lyα emitter (LAE) candidates originally found by Krug et al. at a redshift of z ∼ 7.7 using the Multi-Object Spectrometer for Infra-Red Exploration at Keck. We rule out any line emission at the >5σ level for both objects, putting on solid ground a previous null result for one of the objects. The limits inferred from the non-detections rule out the previous claim of no or even reversed evolution between 5.7 < z < 7.7 in the Lyα luminosity function (LF) and suggest a drop in the Lyα LF consistent with that seen in Lyman break galaxy (LBG) samples. We model the redshift evolution of the LAE LF using the LBG UV-continuum LF and the observed rest-frame equivalent width distribution. From the comparison of our empirical model with the observed LAE distribution, we estimate lower limits of the neutral hydrogen fraction to be 50%-70% at z ∼ 7.7. Together with this, we find a strong evolution in the Lyα optical depth characterized by (1 + z){sup 2.2} {sup ±} {sup 0.5} beyond z = 6, indicative of a strong evolution of the intergalactic medium. Finally, we extrapolate the LAE LF to z ∼ 9 using our model and show that it is unlikely that large area surveys, like UltraVISTA or Euclid, pick up LAEs at this redshift assuming the current depths and area.

  11. The Elephant's Trunk: Spectroscopic diagnostics applied to SOHO/CDS observations of the August 1996 equatorial coronal hole

    NASA Astrophysics Data System (ADS)

    Del Zanna, G.; Bromage, B. J. I.

    1999-05-01

    A large equatorial coronal hole, named the ``Elephant's Trunk,'' was observed by the coronal diagnostic spectrometer (CDS) on board the Solar and Heliospheric Observatory (SOHO) during the last week of August 1996. Spatially averaged spectra within the hole and in neighboring quiet sun regions are analyzed and calibrated in intensity. Spectroscopic diagnostic techniques that make use of the CHIANTI atomic database are applied in an attempt to characterize such large-scale features. Line intensity ratios are used to obtain information on the electron density, temperature, and element abundances inside and outside the coronal hole. The transequatorial coronal hole showed, on average, coronal electron densities Ne~=2-3×108cm-3, a factor of 2 higher than the quiet sun areas near the hole. A differential emission measure analysis shows that emission measures in the coronal hole were much lower at temperatures above a million degrees than in the quiet sun regions. In the Elephant's Trunk, the temperature of peak emission is found to be ~=8×105K, compared to about 9.7×105K in the quiet sun. Indications of a first ionization potential (FIP) effect differentiating between cell centers and the network are found, both in coronal hole and quiet sun regions. A small plume was detected inside the Elephant's Trunk coronal hole at low latitude, on the disc.

  12. SHRINE: Enabling Nationally Scalable Multi-Site Disease Studies

    PubMed Central

    McMurry, Andrew J.; Murphy, Shawn N.; MacFadden, Douglas; Weber, Griffin; Simons, William W.; Orechia, John; Bickel, Jonathan; Wattanasin, Nich; Gilbert, Clint; Trevvett, Philip; Churchill, Susanne; Kohane, Isaac S.

    2013-01-01

    Results of medical research studies are often contradictory or cannot be reproduced. One reason is that there may not be enough patient subjects available for observation for a long enough time period. Another reason is that patient populations may vary considerably with respect to geographic and demographic boundaries thus limiting how broadly the results apply. Even when similar patient populations are pooled together from multiple locations, differences in medical treatment and record systems can limit which outcome measures can be commonly analyzed. In total, these differences in medical research settings can lead to differing conclusions or can even prevent some studies from starting. We thus sought to create a patient research system that could aggregate as many patient observations as possible from a large number of hospitals in a uniform way. We call this system the ‘Shared Health Research Information Network’, with the following properties: (1) reuse electronic health data from everyday clinical care for research purposes, (2) respect patient privacy and hospital autonomy, (3) aggregate patient populations across many hospitals to achieve statistically significant sample sizes that can be validated independently of a single research setting, (4) harmonize the observation facts recorded at each institution such that queries can be made across many hospitals in parallel, (5) scale to regional and national collaborations. The purpose of this report is to provide open source software for multi-site clinical studies and to report on early uses of this application. At this time SHRINE implementations have been used for multi-site studies of autism co-morbidity, juvenile idiopathic arthritis, peripartum cardiomyopathy, colorectal cancer, diabetes, and others. The wide range of study objectives and growing adoption suggest that SHRINE may be applicable beyond the research uses and participating hospitals named in this report. PMID:23533569

  13. A Mixed Methods Sampling Methodology for a Multisite Case Study

    ERIC Educational Resources Information Center

    Sharp, Julia L.; Mobley, Catherine; Hammond, Cathy; Withington, Cairen; Drew, Sam; Stringfield, Sam; Stipanovic, Natalie

    2012-01-01

    The flexibility of mixed methods research strategies makes such approaches especially suitable for multisite case studies. Yet the utilization of mixed methods to select sites for these studies is rarely reported. The authors describe their pragmatic mixed methods approach to select a sample for their multisite mixed methods case study of a…

  14. Building a Community of Evaluation Practice within a Multisite Program

    ERIC Educational Resources Information Center

    Goodyear, Leslie K.

    2011-01-01

    New and novel uses of evaluation processes and findings are possible when a community of practice develops as evaluation stakeholders participate in multisite evaluations in multiple ways. Developing such communities takes advantage of what makes multisite evaluations special. This chapter uses the example of the Innovative Technology Experiences…

  15. The Role of Involvement and Use in Multisite Evaluations

    ERIC Educational Resources Information Center

    Lawrenz, Frances; King, Jean A.; Ooms, Ann

    2011-01-01

    A cross-case analysis of four National Science Foundation (NSF) case studies identified both unique details and common themes related to promoting the use and influence of multisite evaluations. The analysis provided evidence of diverse evaluation use by stakeholders and suggested that people taking part in the multisite evaluations perceived…

  16. Polarimetric and spectroscopic optical observations of the ultra-compact X-ray binary 4U 0614+091

    NASA Astrophysics Data System (ADS)

    Baglio, M. C.; Mainetti, D.; D'Avanzo, P.; Campana, S.; Covino, S.; Russell, D. M.; Shahbaz, T.

    2014-12-01

    Aims: We present a polarimetric and spectroscopic study of the persistent ultra-compact X-ray binary 4U 0614+091 aimed at searching for the emission of a relativistic particle jet and at unveiling the orbital period Porb of the system. Methods: We obtained r-band polarimetric observations with the Telescopio Nazionale Galileo (TNG) equipped with the PAOLO polarimeter and with the Nordic Optical Telescope (NOT) equipped with the ALFOSC instrument, covering ~2 h and ~0.5 h observations, respectively. We carried out low resolution spectroscopy of the system using the ESO Very Large Telescope equipped with FORS1 for ~1.5 h (16 spectra covering the range 4300-8000 Å). Results: The polarimetric analysis performed starting from the TNG dataset revealed a polarisation degree in the r-band of 3% ± 1%. From the NOT dataset, due to the lower signal-to-noise ratio, we could obtain only a 3σ upper limit of 3.4%. From the joining of a spectroscopic and photometric analysis, through the study of the equivalent width variations of the CII 7240 Å line and the r-band light curve, we could find a hint of a ~45 min periodicity. Conclusions: A polarisation degree P of ~3% in the r-band is consistent with the emission of a relativistic particle jet, which is supposed to emit intrinsically linearly polarised synchrotron radiation. Since no variations of P with time have been detected, and the accretion disc of the system does not contain ionised hydrogen, scattering by free electrons in the accretion disc has been rejected. The period of ~45 min obtained through the analysis of the system light curve and of the equivalent width variations of the selected spectral line is probably linked to the presence of a hot spot or a superhump in the accretion disc, and lead to an orbital period ≳1 h for the binary system. Based on observations made with the Italian Telescopio Nazionale Galileo (TNG) operated on the island of La Palma by the Fundación Galileo Galilei of the INAF (Istituto

  17. Far Ultraviolet Spectroscopic Explorer Observations of the Seyfert 1.5 Galaxy NGC 5548 in a Low State

    NASA Technical Reports Server (NTRS)

    Brotherton, M. S.; Green, R. F.; Kriss, G. A.; Oegerle, W.; Kaiser, M. E.; Zheng, W.; Hutchings, J. B.; Fisher, Richard R. (Technical Monitor)

    2001-01-01

    We present far-ultraviolet spectra of the Seyfert 1.5 galaxy NGC 5548 obtained in 2000 June with the Far Ultraviolet Spectroscopic Explorer (FUSE). Our data span the observed wavelength range 915-1185 A at a resolution of approximately 20 km s(exp -1). The spectrum shows a weak continuum and emission from O VI (lambda)(lambda)1032, 1038, C III (lambda)977, and He II (lambda)1085. The FUSE data were obtained when the AGN (Active Galactic Nuclei) was in a low state, which has revealed strong, narrow O VI emission lines. We also resolve intrinsic, associated absorption lines of O VI and the Lyman series. Several distinct kinematic components are present, spanning a velocity range of approximately 0 to -1300 km s(exp -1) relative to systemic, with kinematic structure similar to that seen in previous observations of longer wavelength ultraviolet (UV) lines. We explore the relationships between the far-UV (ultraviolet) absorbers and those seen previously in the UV and X-rays. We find that the high-velocity UV absorption component is consistent with being low-ionization, contrary to some previous claims, and is consistent with its non-detection in high-resolution X-ray spectra. The intermediate velocity absorbers, at -300 to -400 km s(exp -1), show H I and O VI column densities consistent with having contributions from both a high-ionization X-ray absorber and a low-ionization UV absorber. No single far-UV absorbing component can be solely identified with the X-ray absorber.

  18. OPTICAL SPECTROSCOPIC OBSERVATIONS OF GAMMA-RAY BLAZAR CANDIDATES. V. TNG, KPNO, AND OAN OBSERVATIONS OF BLAZAR CANDIDATES OF UNCERTAIN TYPE IN THE NORTHERN HEMISPHERE

    SciTech Connect

    Álvarez Crespo, N.; Massaro, F.; Masetti, N.; Ricci, F.; La Franca, F.; Landoni, M.; Patiño-Álvarez, V.; Chavushyan, V.; Torrealba, J.; D’Abrusco, R.; Paggi, A.; Smith, Howard A.; Jiménez-Bailón, E.; Latronico, L.; Tosti, G.

    2016-02-15

    The extragalactic γ-ray sky is dominated by emission from blazars, a peculiar class of active galactic nuclei. Many of the γ-ray sources included in the Fermi-Large Area Telescope Third Source catalog (3FGL) are classified as blazar candidates of uncertain type (BCUs) because there are no optical spectra available in the literature to confirm their nature. In 2013, we started a spectroscopic campaign to look for the optical counterparts of the BCUs and of the unidentified γ-ray sources to confirm their blazar nature. Whenever possible we also determine their redshifts. Here, we present the results of the observations carried out in the northern hemisphere in 2013 and 2014 at the Telescopio Nazionale Galileo, Kitt Peak National Observatory, and Observatorio Astronómico Nacional in San Pedro Mártir. In this paper, we describe the optical spectra of 25 sources. We confirmed that all of the 15 BCUs observed in our campaign and included in our sample are blazars and we estimated the redshifts for three of them. In addition, we present the spectra for three sources classified as BL Lacs in the literature but with no optical spectra available to date. We found that one of them is a quasar (QSO) at a redshift of z = 0.208 and the other two are BL Lacs. Moreover, we also present seven new spectra for known blazars listed in the Roma-BZCAT that have an uncertain redshift or are classified as BL Lac candidates. We found that one of them, 5BZB J0724+2621, is a “changing look” blazar. According to the spectrum available in the literature, it was classified as a BL Lac, but in our observation we clearly detected a broad emission line that led us to classify this source as a QSO at z = 1.17.

  19. Far Ultraviolet Spectroscopic Explorer Observations of Interstellar Gas toward the Large Magellanic Cloud Star SK -67°05

    NASA Astrophysics Data System (ADS)

    Friedman, S. D.; Howk, J. C.; Andersson, B.-G.; Sembach, K. R.; Ake, T. B.; Roth, K.; Sahnow, D. J.; Savage, B. D.; York, D. G.; Sonneborn, G.; Vidal-Madjar, A.; Wilkinson, E.

    2000-07-01

    We report on measurements of interstellar O VI, H2, P II, Si II, Ar I, and Fe II absorption along the line of sight to Sk -67°05, a B0 Ia star in a diffuse H II region in the western edge of the Large Magellanic Cloud (LMC). We find logN(O VI)=14.40+/-0.04 in the Milky Way component and, using the C IV column density from previous IUE observations, N(C IV)/N(O VI)=1.00+/-0.16, a value similar to other halo measurements made with the Far Ultraviolet Spectroscopic Explorer. In the LMC component, logN(O VI)=13.89+/-0.05 and N(C IV)/N(O VI)<0.4 (3 σ), since only an upper limit on N(C IV) is available. Along this sight line, the LMC is rich in molecular hydrogen [logN(H2)=19.50+/-0.08] in the Milky Way, logN(H2)=14.95+/-0.08. A two-component fit for the excitation temperature of the molecular gas in the LMC gives T01=59+/-5 K for J=0, 1 and Tex=800+/-330 K for J=3, 4, 5. For the Milky Way, T01=99+30-20 K; no excitation temperature could be determined for the higher rotational states. The Milky Way and LMC gas-phase [Fe/P] abundances are ~0.6 and ~0.7 dex lower, respectively, than solar system abundances. These values are similar to [Fe/Zn] measurements for the Milky Way and LMC toward SN 1987A.

  20. Dust tail of the active distant Comet C/2003 WT42 (LINEAR) studied with photometric and spectroscopic observations

    NASA Astrophysics Data System (ADS)

    Korsun, Pavlo P.; Kulyk, Irina V.; Ivanova, Oleksandra V.; Afanasiev, Viktor L.; Kugel, Francois; Rinner, Claudine; Ivashchenko, Yuriy M.

    2010-12-01

    We present the study of dust environment of dynamically new Comet C/2003 WT42 (LINEAR) based on spectroscopic and photometric observations. The comet was observed before and after the perihelion passage at heliocentric distances from 5.2 to 9.5 AU. Although the comet moved beyond the zone where water ice sublimation could be significant, its bright coma and extended dust tail evidenced the high level of physical activity. Afρ values exceeded 3000 cm likely reaching its maximum before the perihelion passage. At the same time, the spectrum of the comet did not reveal molecular emission features above the reflected continuum. Reddening of the continuum derived from the cometary spectrum is nonlinear along the dispersion with the steeper slop in the blue region. The pair of the blue and red continuum images was analyzed to estimate a color of the comet. The mean normalized reflectivity gradient derived from the innermost part of the cometary coma equals to 8% per 1000 Å that is typical for Oort cloud objects. However, the color map shows that the reddening of the cometary dust varies over the coma increasing to 15% per 1000 Å along the tail axis. The photometric images were fitted with a Monte Carlo model to construct the theoretical brightness distribution of the cometary coma and tail and to investigate the development of the cometary activity along the orbit. As the dust particles of distant comets are expected to be icy, we propose here the model, which describes the tail formation taking into account sublimation of grains along their orbits. The chemical composition and structure of these particles are assumed to correspond with Greenberg's interstellar dust model of comet dust. All images were fitted with the close values of the model parameters. According to the results of the modeling, the physical activity of the comet is mainly determined by two active areas with outflows into the wide cones. The obliquity of the rotation axis of the nucleus equals to 20

  1. Mixed mechanisms of multi-site phosphorylation

    PubMed Central

    Suwanmajo, Thapanar; Krishnan, J.

    2015-01-01

    Multi-site phosphorylation is ubiquitous in cell biology and has been widely studied experimentally and theoretically. The underlying chemical modification mechanisms are typically assumed to be distributive or processive. In this paper, we study the behaviour of mixed mechanisms that can arise either because phosphorylation and dephosphorylation involve different mechanisms or because phosphorylation and/or dephosphorylation can occur through a combination of mechanisms. We examine a hierarchy of models to assess chemical information processing through different mixed mechanisms, using simulations, bifurcation analysis and analytical work. We demonstrate how mixed mechanisms can show important and unintuitive differences from pure distributive and processive mechanisms, in some cases resulting in monostable behaviour with simple dose–response behaviour, while in other cases generating new behaviour-like oscillations. Our results also suggest patterns of information processing that are relevant as the number of modification sites increases. Overall, our work creates a framework to examine information processing arising from complexities of multi-site modification mechanisms and their impact on signal transduction. PMID:25972433

  2. Mixed mechanisms of multi-site phosphorylation.

    PubMed

    Suwanmajo, Thapanar; Krishnan, J

    2015-06-06

    Multi-site phosphorylation is ubiquitous in cell biology and has been widely studied experimentally and theoretically. The underlying chemical modification mechanisms are typically assumed to be distributive or processive. In this paper, we study the behaviour of mixed mechanisms that can arise either because phosphorylation and dephosphorylation involve different mechanisms or because phosphorylation and/or dephosphorylation can occur through a combination of mechanisms. We examine a hierarchy of models to assess chemical information processing through different mixed mechanisms, using simulations, bifurcation analysis and analytical work. We demonstrate how mixed mechanisms can show important and unintuitive differences from pure distributive and processive mechanisms, in some cases resulting in monostable behaviour with simple dose-response behaviour, while in other cases generating new behaviour-like oscillations. Our results also suggest patterns of information processing that are relevant as the number of modification sites increases. Overall, our work creates a framework to examine information processing arising from complexities of multi-site modification mechanisms and their impact on signal transduction.

  3. Long-term dynamics of multisite phosphorylation

    PubMed Central

    Rubinstein, Boris Y.; Mattingly, Henry H.; Berezhkovskii, Alexander M.; Shvartsman, Stanislav Y.

    2016-01-01

    Multisite phosphorylation cycles are ubiquitous in cell regulation systems and are studied at multiple levels of complexity, from molecules to organisms, with the ultimate goal of establishing predictive understanding of the effects of genetic and pharmacological perturbations of protein phosphorylation in vivo. Achieving this goal is essentially impossible without mathematical models, which provide a systematic framework for exploring dynamic interactions of multiple network components. Most of the models studied to date do not discriminate between the distinct partially phosphorylated forms and focus on two limiting reaction regimes, distributive and processive, which differ in the number of enzyme–substrate binding events needed for complete phosphorylation or dephosphorylation. Here we use a minimal model of extracellular signal-related kinase regulation to explore the dynamics of a reaction network that includes all essential phosphorylation forms and arbitrary levels of reaction processivity. In addition to bistability, which has been studied extensively in distributive mechanisms, this network can generate periodic oscillations. Both bistability and oscillations can be realized at high levels of reaction processivity. Our work provides a general framework for systematic analysis of dynamics in multisite phosphorylation systems. PMID:27226482

  4. Observing the Fine Structure of Loops through High-resolution Spectroscopic Observations of Coronal Rain with the CRISP Instrument at the Swedish Solar Telescope

    NASA Astrophysics Data System (ADS)

    Antolin, P.; Rouppe van der Voort, L.

    2012-02-01

    Observed in cool chromospheric lines, such as Hα or Ca II H, coronal rain corresponds to cool and dense plasma falling from coronal heights. Considered as a peculiar sporadic phenomenon of active regions, it has not received much attention since its discovery more than 40 years ago. Yet, it has been shown recently that a close relationship exists between this phenomenon and the coronal heating mechanism. Indeed, numerical simulations have shown that this phenomenon is most likely due to a loss of thermal equilibrium ensuing from a heating mechanism acting mostly toward the footpoints of loops. We present here one of the first high-resolution spectroscopic observations of coronal rain, performed with the CRisp Imaging Spectro Polarimeter (CRISP) instrument at the Swedish Solar Telescope. This work constitutes the first attempt to assess the importance of coronal rain in the understanding of the coronal magnetic field in active regions. With the present resolution, coronal rain is observed to literally invade the entire field of view. A large statistical set is obtained in which dynamics (total velocities and accelerations), shapes (lengths and widths), trajectories (angles of fall of the blobs), and thermodynamic properties (temperatures) of the condensations are derived. Specifically, we find that coronal rain is composed of small and dense chromospheric cores with average widths and lengths of ~310 km and ~710 km, respectively, average temperatures below 7000 K, displaying a broad distribution of falling speeds with an average of ~70 km s-1, and accelerations largely below the effective gravity along loops. Through estimates of the ion-neutral coupling in the blobs we show that coronal rain acts as a tracer of the coronal magnetic field, thus supporting the multi-strand loop scenario, and acts as a probe of the local thermodynamic conditions in loops. We further elucidate its potential in coronal heating. We find that the cooling in neighboring strands occurs

  5. OBSERVING THE FINE STRUCTURE OF LOOPS THROUGH HIGH-RESOLUTION SPECTROSCOPIC OBSERVATIONS OF CORONAL RAIN WITH THE CRISP INSTRUMENT AT THE SWEDISH SOLAR TELESCOPE

    SciTech Connect

    Antolin, P.; Rouppe van der Voort, L. E-mail: v.d.v.l.rouppe@astro.uio.no

    2012-02-01

    Observed in cool chromospheric lines, such as H{alpha} or Ca II H, coronal rain corresponds to cool and dense plasma falling from coronal heights. Considered as a peculiar sporadic phenomenon of active regions, it has not received much attention since its discovery more than 40 years ago. Yet, it has been shown recently that a close relationship exists between this phenomenon and the coronal heating mechanism. Indeed, numerical simulations have shown that this phenomenon is most likely due to a loss of thermal equilibrium ensuing from a heating mechanism acting mostly toward the footpoints of loops. We present here one of the first high-resolution spectroscopic observations of coronal rain, performed with the CRisp Imaging Spectro Polarimeter (CRISP) instrument at the Swedish Solar Telescope. This work constitutes the first attempt to assess the importance of coronal rain in the understanding of the coronal magnetic field in active regions. With the present resolution, coronal rain is observed to literally invade the entire field of view. A large statistical set is obtained in which dynamics (total velocities and accelerations), shapes (lengths and widths), trajectories (angles of fall of the blobs), and thermodynamic properties (temperatures) of the condensations are derived. Specifically, we find that coronal rain is composed of small and dense chromospheric cores with average widths and lengths of {approx}310 km and {approx}710 km, respectively, average temperatures below 7000 K, displaying a broad distribution of falling speeds with an average of {approx}70 km s{sup -1}, and accelerations largely below the effective gravity along loops. Through estimates of the ion-neutral coupling in the blobs we show that coronal rain acts as a tracer of the coronal magnetic field, thus supporting the multi-strand loop scenario, and acts as a probe of the local thermodynamic conditions in loops. We further elucidate its potential in coronal heating. We find that the cooling

  6. What can We Learn about Solar Coronal Mass Ejections, Coronal Dimmings, and Extreme-ultraviolet Jets through Spectroscopic Observations?

    NASA Astrophysics Data System (ADS)

    Tian, Hui; McIntosh, Scott W.; Xia, Lidong; He, Jiansen; Wang, Xin

    2012-04-01

    Solar eruptions, particularly coronal mass ejections (CMEs) and extreme-ultraviolet (EUV) jets, have rarely been investigated with spectroscopic observations. We analyze several data sets obtained by the EUV Imaging Spectrometer on board Hinode and find various types of flows during CMEs and jet eruptions. CME-induced dimming regions are found to be characterized by significant blueshift and enhanced line width by using a single Gaussian fit, while a red-blue (RB) asymmetry analysis and an RB-guided double Gaussian fit of the coronal line profiles indicate that these are likely caused by the superposition of a strong background emission component and a relatively weak (~10%), high-speed (~100 km s-1) upflow component. This finding suggests that the outflow velocity in the dimming region is probably of the order of 100 km s-1, not ~20 km s-1 as reported previously. These weak, high-speed outflows may provide a significant amount of mass to refill the corona after the eruption of CMEs, and part of them may experience further acceleration and eventually become solar wind streams that can serve as an additional momentum source of the associated CMEs. Density and temperature diagnostics of the dimming region suggest that dimming is primarily an effect of density decrease rather than temperature change. The mass losses in dimming regions as estimated from different methods are roughly consistent with each other, and they are 20%-60% of the masses of the associated CMEs. With the guide of RB asymmetry analysis, we also find several temperature-dependent outflows (speed increases with temperature) immediately outside the (deepest) dimming region. These outflows may be evaporation flows that are caused by the enhanced thermal conduction or nonthermal electron beams along reconnecting field lines, or induced by the interaction between the opened field lines in the dimming region and the closed loops in the surrounding plage region. In an erupted CME loop and an EUV jet

  7. A Hierarchical Modeling Approach to Data Analysis and Study Design in a Multi-Site Experimental fMRI Study

    ERIC Educational Resources Information Center

    Zhou, Bo; Konstorum, Anna; Duong, Thao; Tieu, Kinh H.; Wells, William M.; Brown, Gregory G.; Stern, Hal S.; Shahbaba, Babak

    2013-01-01

    We propose a hierarchical Bayesian model for analyzing multi-site experimental fMRI studies. Our method takes the hierarchical structure of the data (subjects are nested within sites, and there are multiple observations per subject) into account and allows for modeling between-site variation. Using posterior predictive model checking and model…

  8. Spectroscopic mode identification of main-sequence non-radially pulsating stars

    NASA Astrophysics Data System (ADS)

    Maisonneuve, F.; Pollard, K. R.; Cottrell, P. L.; Kilmartin, P. M.; Wright, D. J.; De Cat, P.

    2010-07-01

    We are undertaking an extensive observational campaign of a number of non-radially pulsating stars using the high-resolution HERCULES spectrograph on the 1.0-m telescope at the Mt John University Observatory. This is part of a large world-wide multi-site campaign to improve mode-identification techniques in non-radially pulsating stars, particularly for g-mode pulsators. This paper outlines our campaign and presents preliminary results for one γ Doradus star, HD 40745, and one β Cephei star, HD 61068. We have used a representative cross-correlation line-profile technique presented by Wright in 2008 to extract line profiles and these have then been analyzed using the FAMIAS package due to Zima published in 2006 to derive a spectroscopic mode identification.

  9. Evaluation of spectroscopic databases through radiative transfer simulations compared to observations. Application to the validation of GEISA 2015 with IASI and TCCON

    NASA Astrophysics Data System (ADS)

    Armante, Raymond; Scott, Noelle; Crevoisier, Cyril; Capelle, Virginie; Crepeau, Laurent; Jacquinet, Nicole; Chédin, Alain

    2016-09-01

    The quality of spectroscopic parameters that serve as input to forward radiative transfer models are essential to fully exploit remote sensing of Earth atmosphere. However, the process of updating spectroscopic databases in order to provide the users with a database that insures an optimal characterization of spectral properties of molecular absorption for radiative transfer modeling is challenging. The evaluation of the databases content and the underlying choices made by the managing team is thus a crucial step. Here, we introduce an original and powerful approach for evaluating spectroscopic parameters: the Spectroscopic Parameters And Radiative Transfer Evaluation (SPARTE) chain. The SPARTE chain relies on the comparison between forward radiative transfer simulations made by the 4A radiative transfer model and observations of spectra made from various observations collocated over several thousands of well-characterized atmospheric situations. Averaging the resulting 'calculated-observed spectral' residuals minimizes the random errors coming from both the radiometric noise of the instruments and the imperfect description of the atmospheric state. The SPARTE chain can be used to evaluate any spectroscopic databases, from the visible to the microwave, using any type of remote sensing observations (ground-based, airborne or space-borne). We show that the comparison of the shape of the residuals enables: (i) identifying incorrect line parameters (line position, intensity, width, pressure shift, etc.), even for molecules for which interferences between the lines have to be taken into account; (ii) proposing revised values, in cooperation with contributing teams; and (iii) validating the final updated parameters. In particular, we show that the simultaneous availability of two databases such as GEISA and HITRAN helps identifying remaining issues in each database. The SPARTE chain has been here applied to the validation of the update of GEISA-2015 in 2 spectral regions

  10. Multisite Interactions in Lattice-Gas Models

    NASA Astrophysics Data System (ADS)

    Einstein, T. L.; Sathiyanarayanan, R.

    For detailed applications of lattice-gas models to surface systems, multisite interactions often play at least as significant a role as interactions between pairs of adatoms that are separated by a few lattice spacings. We recall that trio (3-adatom, non-pairwise) interactions do not inevitably create phase boundary asymmetries about half coverage. We discuss a sophisticated application to an experimental system and describe refinements in extracting lattice-gas energies from calculations of total energies of several different ordered overlayers. We describe how lateral relaxations complicate matters when there is direct interaction between the adatoms, an issue that is important when examining the angular dependence of step line tensions. We discuss the connector model as an alternative viewpoint and close with a brief account of recent work on organic molecule overlayers.

  11. Optical low-dispersion spectroscopic observations of Comet 103P/Hartley 2 at Koyama Astronomical Observatory during the EPOXI flyby

    NASA Astrophysics Data System (ADS)

    Shinnaka, Yoshiharu; Kawakita, Hideyo; Kobayashi, Hitomi; Naka, Chiharu; Arai, Akira; Arasaki, Takayuki; Kitao, Eiji; Taguchi, Gaku; Ikeda, Yuji

    2013-02-01

    We performed low-dispersion spectroscopic observations of Comet 103P/Hartley 2 in optical wavelengths using the LOSA/F2 mounted on the 1.3 m-Araki telescope at Koyama Astronomical Observatory on UT 2010 November 4 during the close approach of the Deep Impact spacecraft to the nucleus of Comet 103P/Hartley 2 in the EPOXI mission flyby. Our observations have revealed the chemistry of the coma at optical wavelengths; including CN, C3, C2 and NH2 along with H2O from [OI] emission at 6300 Å. Resultant mixing ratios of these radicals put the comet into the normal group in chemical composition. The mixing ratios with respect to H2O obtained in our observations are basically consistent with the previous optical spectro-photometric observations of Comet 103P/Hartley 2 in 1991 by A'Hearn et al. (A'Hearn, M.F., Millis, R.L., Schleicher, D.G., Osip, D.J., Birch, P.V. [1995]. Icarus 118, 223-270), the optical spectroscopic observations in 1998 by Fink (Fink, U. [2009]. Icarus 201, 311-334) and also consistent with the observations on UT 2010 October 27 and 29 by Lara et al. (Lara, L.M., Lin, Z.-Y., Meech, K. [2011]. Astron. Astrophys. 532, A87) (but only for the ratio relative to CN).

  12. Exploration of scanning effects in multi-site structural MRI studies

    PubMed Central

    Chen, Jiayu; Liu, Jingyu; Calhoun, Vince D.; Arias-Vasquez, Alejandro; Zwiers, Marcel P.; Gupta, Cota Navin; Franke, Barbara; Turner, Jessica A.

    2014-01-01

    Background Pooling of multi-site MRI data is often necessary when a large cohort is desired. However, different scanning platforms can introduce systematic differences which confound true effects of interest. One may reduce multi-site bias by calibrating pivotal scanning parameters, or include them as covariates to improve the data integrity. New method In the present study we use a source-based morphometry (SBM) model to explore scanning effects in multi-site sMRI studies and develop a data-driven correction. Specifically, independent components are extracted from the data and investigated for associations with scanning parameters to assess the influence. The identified scanning-related components can be eliminated from the original data for correction. Results A small set of SBM components captured most of the variance associated with the scanning differences. In a dataset of 1460 healthy subjects, pronounced and independent scanning effects were observed in brainstem and thalamus, associated with magnetic field strength-inversion time and RF-receiving coil. A second study with 110 schizophrenia patients and 124 healthy controls demonstrated that scanning effects can be effectively corrected with the SBM approach. Comparison with existing method(s) Both SBM and GLM correction appeared to effectively eliminate the scanning effects. Meanwhile, the SBM-corrected data yielded a more significant patient versus control group difference and less questionable findings. Conclusions It is important to calibrate scanning settings and completely examine individual parameters for the control of confounding effects in multi-site sMRI studies. Both GLM and SBM correction can reduce scanning effects, though SBM’s data-driven nature provides additional flexibility and is better able to handle collinear effects. PMID:24785589

  13. Nonlinear instabilities of multi-site breathers in Klein-Gordon lattices

    DOE PAGES

    Cuevas-Maraver, Jesus; Kevrekidis, Panayotis G.; Pelinovsky, Dmitry E.

    2016-08-01

    Here, we explore the possibility of multi-site breather states in a nonlinear Klein–Gordon lattice to become nonlinearly unstable, even if they are found to be spectrally stable. The mechanism for this nonlinear instability is through the resonance with the wave continuum of a multiple of an internal mode eigenfrequency in the linearization of excited breather states. For the nonlinear instability, the internal mode must have its Krein signature opposite to that of the wave continuum. This mechanism is not only theoretically proposed, but also numerically corroborated through two concrete examples of the Klein–Gordon lattice with a soft (Morse) and amore » hard (Φ4) potential. Compared to the case of the nonlinear Schrödinger lattice, the Krein signature of the internal mode relative to that of the wave continuum may change depending on the period of the multi-site breather state. For the periods for which the Krein signatures of the internal mode and the wave continuum coincide, multi-site breather states are observed to be nonlinearly stable.« less

  14. Nonlinear instabilities of multi-site breathers in Klein-Gordon lattices

    SciTech Connect

    Cuevas-Maraver, Jesus; Kevrekidis, Panayotis G.; Pelinovsky, Dmitry E.

    2016-08-01

    Here, we explore the possibility of multi-site breather states in a nonlinear Klein–Gordon lattice to become nonlinearly unstable, even if they are found to be spectrally stable. The mechanism for this nonlinear instability is through the resonance with the wave continuum of a multiple of an internal mode eigenfrequency in the linearization of excited breather states. For the nonlinear instability, the internal mode must have its Krein signature opposite to that of the wave continuum. This mechanism is not only theoretically proposed, but also numerically corroborated through two concrete examples of the Klein–Gordon lattice with a soft (Morse) and a hard (Φ4) potential. Compared to the case of the nonlinear Schrödinger lattice, the Krein signature of the internal mode relative to that of the wave continuum may change depending on the period of the multi-site breather state. For the periods for which the Krein signatures of the internal mode and the wave continuum coincide, multi-site breather states are observed to be nonlinearly stable.

  15. Variations in the D/H Ratio of Extended Sight Lines from Far Ultraviolet Spectroscopic Explorer Observations

    NASA Astrophysics Data System (ADS)

    Oliveira, Cristina M.; Hébrard, Guillaume

    2006-12-01

    We use new FUSE data to determine the column densities of interstellar D I, N I, O I, Fe II, and H2 along the HD 41161 and HD 53975 sight lines. Together with N(H I) from the literature, we derive D/H, N/H, and O/H ratios. These sight lines have logN(H I)>21.00 and probe gas up to ~1300 pc, allowing us to determine the gas-phase D/H ratio in a hydrogen column density range, logN(H)>20.70, where the only five measurements available in the literature yield a weighted average of D/H=(0.86+/-0.08)×10-5. We find D/H=(2.14+0.51-0.43)×10-5 along the HD 41161 sight line. This ratio is ~3 σ higher than the weighted mean D/H ratio quoted above, while the D/H ratio for the HD 53975 line of sight, D/H=(1.02+0.23-0.20)×10-5, agrees within the 1 σ uncertainties. Our D/H measurement along the HD 41161 sight line presents the first evidence of variations of D/H at high N(H). Our result seems to indicate either that the long sight lines that, according to the deuterium depletion model, are dominated by cold undisturbed gas where deuterium would be depleted onto carbonaceous grains occur at higher N(H) than previously thought, or that the clumping of low D/H values in the literature for the long sight lines has another explanation. Both of the O/H ratios derived here, (9.12+2.15-1.83)×10-4 and (5.37+1.35-1.14)×10-4 (for HD 41161 and HD 53975, respectively), are higher than what has been found by other authors. Finally, we derive (N/H)×105=8.32+2.09-1.76 and 5.07+1.45-1.21, and (D/O)×102=2.29+0.40-0.35 and 1.91+0.51-0.43, for HD 41161 and HD 53975, respectively. In addition, the relatively high signal-to-noise ratio of the HD 41161 data allows us to place constraints on the f-values of some neutral chlorine transitions present in the FUSE bandpass for which only theoretical values are available. Based on observations made with the NASA-CNES-CSA Far Ultraviolet Spectroscopic Explorer. FUSE is operated for NASA by the Johns Hopkins University under NASA contract NAS5-32985.

  16. Spectroscopic analyses of subluminous B stars: observational constraints for the theory of stellar evolution, pulsation, and diffusion

    NASA Astrophysics Data System (ADS)

    Edelmann, Heinz

    2003-06-01

    This thesis deals with quantitative spectroscopic analyses of large samples of subluminous B stars in order to find constraints the theory of stellar evolution, pulsation, and diffusion. Subluminous B stars, also known as subdwarf B (sdB) stars, are very important in several respects: They dominate the population of faint blue stars in high galactic latitudes, and are found both in the field and in globular clusters. Therefore, sdB stars are important to understand the structure and evolution of our galaxy. From the cosmological point of view, they are candidate progenitors of supernovae of type Ia due to their membership in close binary systems. In the context of stellar astrophysics, subdwarf B stars play an important role because several of them are discovered to show non-radial pulsations, which allows to probe their interior by asteroseismology. Last but not least, sdB stars show very peculiar element abundance patterns, probably caused by diffusion processes. Subluminous B stars are generally considered to be core helium-burning stars with extremely thin hydrogen envelopes (< 0.02M) and masses around 0.5M. In the Hertzsprung-Russell diagram they populate a very narrow area which lies on a blue-ward extension of the horizontal branch (HB), the so called "Extreme Horizontal Branch" (EHB). Due to their thin hydrogen-rich envelope, they cannot sustain a hydrogen-burning shell. This means that the sdB stars cannot ascend the asymptotic giant branch after the end of the helium-core burning, but should evolve directly to the white dwarf graveyard. However, according to standard stellar evolution theory, subdwarf B stars should not exist. Their evolution is still unclear and several scenarios are under debate. For all these investigations, knowledge of the stellar parameters (effective temperature, gravity and chemical composition) is very important to verify or discard theoretical models and predictions. Numerous observing runs have been performed mostly by myself

  17. Multisite adsorption of cadmium on goethite

    SciTech Connect

    Venema, P.; Hiemstra, T.; Riemsdijk, W.H. van

    1996-11-10

    Recently a new general ion adsorption model has been developed for ion binding to mineral surfaces (Hiemstra and van Riemsdijk, 1996). The model uses the Pauling concept of charge distribution (CD) and is an extension of the multi-site complexation (MUSIC) approach. In the CD-MUSIC model the charge of an adsorbing ion that forms an inner sphere complex is distributed over its ligands, which are present in two different electrostatic planes. In this paper the authors have applied the CD-MUSIC model to the adsorption of metal cations, using an extended data set for cadmium adsorbing on goethite. The adsorption of cadmium and the cadmium-proton exchange ratio were measured as function of metal ion concentration, pH, and ionic strength. The data could be described well, taking into account the surface heterogeneity resulting from the presence of two different crystal planes (the dominant 110 face and the minor 021 face). The surface species used in the model are consistent with recent EXAFS data. In accordance with the EXAFS results, high-affinity complexes at the 021 face were used in the model.

  18. Encoded multisite two-photon microscopy

    PubMed Central

    Ducros, Mathieu; Houssen, Yannick Goulam; Bradley, Jonathan; de Sars, Vincent; Charpak, Serge

    2013-01-01

    The advent of scanning two-photon microscopy (2PM) has created a fertile new avenue for noninvasive investigation of brain activity in depth. One principal weakness of this method, however, lies with the limit of scanning speed, which makes optical interrogation of action potential-like activity in a neuronal network problematic. Encoded multisite two-photon microscopy (eMS2PM), a scanless method that allows simultaneous imaging of multiple targets in depth with high temporal resolution, addresses this drawback. eMS2PM uses a liquid crystal spatial light modulator to split a high-power femto-laser beam into multiple subbeams. To distinguish them, a digital micromirror device encodes each subbeam with a specific binary amplitude modulation sequence. Fluorescence signals from all independently targeted sites are then collected simultaneously onto a single photodetector and site-specifically decoded. We demonstrate that eMS2PM can be used to image spike-like voltage transients in cultured cells and fluorescence transients (calcium signals in neurons and red blood cells in capillaries from the cortex) in depth in vivo. These results establish eMS2PM as a unique method for simultaneous acquisition of neuronal network activity. PMID:23798397

  19. Encoded multisite two-photon microscopy.

    PubMed

    Ducros, Mathieu; Goulam Houssen, Yannick; Bradley, Jonathan; de Sars, Vincent; Charpak, Serge

    2013-08-06

    The advent of scanning two-photon microscopy (2PM) has created a fertile new avenue for noninvasive investigation of brain activity in depth. One principal weakness of this method, however, lies with the limit of scanning speed, which makes optical interrogation of action potential-like activity in a neuronal network problematic. Encoded multisite two-photon microscopy (eMS2PM), a scanless method that allows simultaneous imaging of multiple targets in depth with high temporal resolution, addresses this drawback. eMS2PM uses a liquid crystal spatial light modulator to split a high-power femto-laser beam into multiple subbeams. To distinguish them, a digital micromirror device encodes each subbeam with a specific binary amplitude modulation sequence. Fluorescence signals from all independently targeted sites are then collected simultaneously onto a single photodetector and site-specifically decoded. We demonstrate that eMS2PM can be used to image spike-like voltage transients in cultured cells and fluorescence transients (calcium signals in neurons and red blood cells in capillaries from the cortex) in depth in vivo. These results establish eMS2PM as a unique method for simultaneous acquisition of neuronal network activity.

  20. The Wasilewski sample of emission-line galaxies - Follow-up CCD imaging and spectroscopic and IRAS observations

    NASA Technical Reports Server (NTRS)

    Bothun, Gregory D.; Schmitz, Mark; Halpern, Jules P.; Lonsdale, Carol J.; Impey, Chris

    1989-01-01

    The results of an extensive imaging and spectroscopic follow-up of the objective prism-selected emission line galaxy (ELG) sample of Wasilewski (1982) are presented. Fluxes at 12, 25, 60, and 100 microns were also obtained from the coadded IRAS survey data. ELGs found by objective prism surveys are found to be generally small and underluminous galaxies which usually have higher than average optical surface brightness. The Seyfert detection rate in objective prism surveys is roughly 10 percent and the ratio of the space densities of Seyfert 2 to Seyfert 1 galaxies is significantly larger than unity. Most of the galaxies selected by objective prism surveys are star-forming, late-type spirals which often show disturbed morphology. About 25 percent of the galaxies detected by the surveys are faint, high-excitation metal-poor compact H II regions.

  1. Real-Time Enrollment Dashboard For Multisite Clinical Trials

    PubMed Central

    Mattingly, William A; Kelley, Robert R; Wiemken, Timothy L; Chariker, Julia H; Peyrani, Paula; Guinn, Brian E; Binford, Laura E; Buckner, Kimberley; Ramirez, Julio

    2015-01-01

    Objective Achieving patient recruitment goals are critical for the successful completion of a clinical trial. We designed and developed a web-based dashboard for assisting in the management of clinical trial screening and enrollment. Materials and Methods We use the dashboard to assist in the management of two observational studies of community-acquired pneumonia. Clinical research associates and managers using the dashboard were surveyed to determine its effectiveness as compared with traditional direct communication. Results The dashboard has been in use since it was first introduced in May of 2014. Of the 23 staff responding to the survey, 77% felt that it was easier or much easier to use the dashboard for communication than to use direct communication. Conclusion We have designed and implemented a visualization dashboard for managing multi-site clinical trial enrollment in two community acquired pneumonia studies. Information dashboards are a useful tool for clinical trial management. They can be used as a standalone trial information tool or included into a larger management system. PMID:26878068

  2. Spectroscopic properties of holmium doped ? crystals

    NASA Astrophysics Data System (ADS)

    Dominiak-Dzik, G.; Golab, S.; Zawadzka, J.; Ryba-Romanowski, W.; Lukasiewicz, T.; Swirkowicz, M.

    1998-11-01

    The spectroscopic properties of 0953-8984/10/45/016/img11 ions in 0953-8984/10/45/016/img12 crystals have been investigated using optical absorption, luminescence and lifetime measurements in the 5-300 K temperature range. The low temperature, polarized absorption spectra of 0953-8984/10/45/016/img11 in this matrix have allowed us to identify the Stark levels of the different multiplets up to 30 000 0953-8984/10/45/016/img14. The results are consistent with 0953-8984/10/45/016/img15 symmetry for the rare-earth ions and a singlet A character for the lowest Stark level of the 0953-8984/10/45/016/img16 ground state. Several transitions show additional structure which indicates multi-site occupancy for the 0953-8984/10/45/016/img11 ions. The measured oscillator strengths of the transitions between the J manifolds at 300 K are compared with those derived from the Judd-Ofelt theory. The radiative transition rates and radiative lifetimes have been calculated. The luminescence observed at 5 K has been attributed to 0953-8984/10/45/016/img18 (18 100 0953-8984/10/45/016/img14), 0953-8984/10/45/016/img20 (15 060 0953-8984/10/45/016/img14) and 0953-8984/10/45/016/img22 (13 150 0953-8984/10/45/016/img14) transitions. The obtained data are used to discuss the radiative properties for luminescent levels of 0953-8984/10/45/016/img11 ions in the 0953-8984/10/45/016/img25 matrix. The emission cross-section of a potential laser line at 2 0953-8984/10/45/016/img26m connected with the 0953-8984/10/45/016/img27 transition is estimated.

  3. Coordination and Management of Multisite Complementary and Alternative Medicine (CAM) Therapies: Experience from a Multisite Reflexology Intervention Trial

    PubMed Central

    Rahbar, Mohammad H.; Wyatt, Gwen; Sikorskii, Alla; Victorson, David; Ardjomand-Hessabi, Manouchehr

    2011-01-01

    Background Multisite randomized clinical trials allow for increased research collaboration among investigators and expedite data collection efforts. As a result, government funding agencies typically look favorably upon this approach. As the field of complementary and alternative medicine (CAM) continues to evolve, so do increased calls for the use of more rigorous study design and trial methodologies, which can present challenges for investigators. Purpose To describe the processes involved in the coordination and management of a multisite randomized clinical trial of a CAM intervention. Methods Key aspects related to the coordination and management of a multisite CAM randomized clinical trial are presented, including organizational and site selection considerations, recruitment concerns and issues related to data collection and randomization to treatment groups. Management and monitoring of data, as well as quality assurance procedures are described. Finally, a real world perspective is shared from a recently conducted multisite randomized clinical trial of reflexology for women diagnosed with advanced breast cancer. Results The use of multiple sites in the conduct of CAM-based randomized clinical trials can provide an efficient, collaborative and robust approach to study coordination and data collection that maximizes efficiency and ensures the quality of results. Conclusions Multisite randomized clinical trial designs can offer the field of CAM research a more standardized and efficient approach to examine the effectiveness of novel therapies and treatments. Special attention must be given to intervention fidelity, consistent data collection and ensuring data quality. Assessment and reporting of quantitative indicators of data quality should be required. PMID:21664296

  4. Strategies to Encourage Adoption in Multi-Site Clinical Trials

    PubMed Central

    Guydish, Joseph; Tajima, Barbara; Manser, Sarah; Jessup, Martha

    2012-01-01

    The National Institute on Drug Abuse (NIDA) Clinical Trials Network (CTN) is intended to test promising drug abuse treatment models in multi-site clinical trials, and to support adoption of new interventions into clinical practice. Using qualitative research methods we studied adoption in the context of two multi-site clinical trials, one outside the CTN and one within the CTN. A total of 71 participants, representing 8 organizational levels ranging from clinic staff to clinical trial leaders, were interviewed about their role in the clinical trial, its interactions with clinics, and intervention adoption. Drawing on conceptual themes identified in these interviews, we report strategies that could be applied in planning, development and implementation of multi-site studies to better support adoption of tested interventions in study clinics after the trial has ended. Planning for adoption in the early stages of protocol development will enhance integration of new interventions into practice. PMID:17306726

  5. Development of a high dynamic range spectroscopic system for observation of neutral hydrogen atom density distribution in Large Helical Device core plasma

    SciTech Connect

    Fujii, K. Atsumi, S.; Watanabe, S.; Shikama, T.; Hasuo, M.; Goto, M.; Morita, S.

    2014-02-15

    We report development of a high dynamic range spectroscopic system comprising a spectrometer with 30% throughput and a camera with a low-noise fast-readout complementary metal-oxide semiconductor sensor. The system achieves a 10{sup 6} dynamic range (∼20 bit resolution) and an instrumental function approximated by a Voigt profile with Gauss and Lorentz widths of 31 and 0.31 pm, respectively, for 656 nm light. The application of the system for line profile observations of the Balmer-α emissions from high temperature plasmas generated in the Large Helical Device is also presented. In the observed line profiles, emissions are detected in far wings more than 1.0 nm away from the line center, equivalent to neutral hydrogen atom kinetic energies above 1 keV. We evaluate atom density distributions in the core plasma by analyzing the line profiles.

  6. Spectroscopic survey of Kepler stars. I. HERMES/Mercator observations of A- and F-type stars

    NASA Astrophysics Data System (ADS)

    Niemczura, E.; Murphy, S. J.; Smalley, B.; Uytterhoeven, K.; Pigulski, A.; Lehmann, H.; Bowman, D. M.; Catanzaro, G.; van Aarle, E.; Bloemen, S.; Briquet, M.; De Cat, P.; Drobek, D.; Eyer, L.; Gameiro, J. F. S.; Gorlova, N.; Kamiński, K.; Lampens, P.; Marcos-Arenal, P.; Pápics, P. I.; Vandenbussche, B.; Van Winckel, H.; Stȩślicki, M.; Fagas, M.

    2015-07-01

    The Kepler space mission provided near-continuous and high-precision photometry of about 207 000 stars, which can be used for asteroseismology. However, for successful seismic modeling it is equally important to have accurate stellar physical parameters. Therefore, supplementary ground-based data are needed. We report the results of the analysis of high-resolution spectroscopic data of A- and F-type stars from the Kepler field, which were obtained with the HERMES spectrograph on the Mercator telescope. We determined spectral types, atmospheric parameters and chemical abundances for a sample of 117 stars. Hydrogen Balmer, Fe I, and Fe II lines were used to derive effective temperatures, surface gravities, and microturbulent velocities. We determined chemical abundances and projected rotational velocities using a spectrum synthesis technique. The atmospheric parameters obtained were compared with those from the Kepler Input Catalogue (KIC), confirming that the KIC effective temperatures are underestimated for A stars. Effective temperatures calculated by spectral energy distribution fitting are in good agreement with those determined from the spectral line analysis. The analysed sample comprises stars with approximately solar chemical abundances, as well as chemically peculiar stars of the Am, Ap, and λ Boo types. The distribution of the projected rotational velocity, vsin i, is typical for A and F stars and ranges from 8 to about 280 km s-1, with a mean of 134 km s-1.

  7. The Growth of Multi-Site Fatigue Damage in Fuselage Lap Joints

    NASA Technical Reports Server (NTRS)

    Piascik, Robert S.; Willard, Scott A.

    1999-01-01

    Destructive examinations were performed to document the progression of multi-site damage (MSD) in three lap joint panels that were removed from a full scale fuselage test article that was tested to 60,000 full pressurization cycles. Similar fatigue crack growth characteristics were observed for small cracks (50 microns to 10 mm) emanating from counter bore rivets, straight shank rivets, and 100 deg counter sink rivets. Good correlation of the fatigue crack growth data base obtained in this study and FASTRAN Code predictions show that the growth of MSD in the fuselage lap joint structure can be predicted by fracture mechanics based methods.

  8. Multisite Testing of the Discrete Address Beacon System (DABS).

    DTIC Science & Technology

    1981-07-01

    surveillance processing , data link processing , and intersensor communications. It is concluded that the performance of the DABS sensors in multisite...of completed page autholed , ACKNOWLEDGMENTS Assistance in test conduct and data analysis was rendered by R. Frack , L. Baker, R. Gilmartin, Major...Collection 10 TEST RESULTS AND ANALYSIS 12 Network Management 12 Surveillance Processing 30 Data Link Message Processing 32 Intersensor Communications

  9. A Gateway MultiSite Recombination Cloning Toolkit

    PubMed Central

    Petersen, Lena K.; Stowers, R. Steven

    2011-01-01

    The generation of DNA constructs is often a rate-limiting step in conducting biological experiments. Recombination cloning of single DNA fragments using the Gateway system provided an advance over traditional restriction enzyme cloning due to increases in efficiency and reliability. Here we introduce a series of entry clones and a destination vector for use in two, three, and four fragment Gateway MultiSite recombination cloning whose advantages include increased flexibility and versatility. In contrast to Gateway single-fragment cloning approaches where variations are typically incorporated into model system-specific destination vectors, our Gateway MultiSite cloning strategy incorporates variations in easily generated entry clones that are model system-independent. In particular, we present entry clones containing insertions of GAL4, QF, UAS, QUAS, eGFP, and mCherry, among others, and demonstrate their in vivo functionality in Drosophila by using them to generate expression clones including GAL4 and QF drivers for various trp ion channel family members, UAS and QUAS excitatory and inhibitory light-gated ion channels, and QUAS red and green fluorescent synaptic vesicle markers. We thus establish a starter toolkit of modular Gateway MultiSite entry clones potentially adaptable to any model system. An inventory of entry clones and destination vectors for Gateway MultiSite cloning has also been established (www.gatewaymultisite.org). PMID:21931740

  10. A Multisite Cluster Randomized Field Trial of Open Court Reading

    ERIC Educational Resources Information Center

    Borman, Geoffrey D.; Dowling, N. Maritza; Schneck, Carrie

    2008-01-01

    In this article, the authors report achievement outcomes of a multisite cluster randomized field trial of Open Court Reading 2005 (OCR), a K-6 literacy curriculum published by SRA/McGraw-Hill. The participants are 49 first-grade through fifth-grade classrooms from predominantly minority and poor contexts across the nation. Blocking by grade level…

  11. A Multisite Evaluation of Reading Is Fundamental: Summary Report.

    ERIC Educational Resources Information Center

    Parker, Ronald K.; And Others

    Reading Is Fundamental (RIF) is a national program that seeks to motivate children to read. Implemented by local sponsors and aimed at disadvantaged groups, it offers participating children a wide selection of attractive paperback books about interesting people, places, and events. The multisite evaluation summarized in this report studied…

  12. A Multisite Evaluation of Reading Is Fundamental: Technical Report.

    ERIC Educational Resources Information Center

    Parker, Ronald K.; And Others

    Reading Is Fundamental (RIF) is a national program that seeks to motivate children to read. Implemented by local sponsors and aimed at disadvantaged groups, it offers participating children a wide selection of attractive paperbound books about interesting people, places, and events. The multisite evaluation discussed in this technical report…

  13. Hydrological modeling using a multi-site stochastic weather generator

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Weather data is usually required at several locations over a large watershed, especially when using distributed models for hydrological simulations. In many applications, spatially correlated weather data can be provided by a multi-site stochastic weather generator which considers the spatial correl...

  14. Strengthening Multisite Educational Interventions: An Illustration with Multilevel Modeling.

    ERIC Educational Resources Information Center

    Pituch, Keenan A.; Miller, John W.

    1999-01-01

    Uses data from an evaluation of an alternative teacher certification program to illustrate the value and use of multilevel models to examine site-to-site outcome differences data from multisite evaluations, showing how a traditional analysis approach can overlook effective interventions and miss important links between program implementation and…

  15. The clustering of galaxies in the completed SDSS-III Baryon Oscillation Spectroscopic Survey: observational systematics and baryon acoustic oscillations in the correlation function

    NASA Astrophysics Data System (ADS)

    Ross, Ashley J.; Beutler, Florian; Chuang, Chia-Hsun; Pellejero-Ibanez, Marcos; Seo, Hee-Jong; Vargas-Magaña, Mariana; Cuesta, Antonio J.; Percival, Will J.; Burden, Angela; Sánchez, Ariel G.; Grieb, Jan Niklas; Reid, Beth; Brownstein, Joel R.; Dawson, Kyle S.; Eisenstein, Daniel J.; Ho, Shirley; Kitaura, Francisco-Shu; Nichol, Robert C.; Olmstead, Matthew D.; Prada, Francisco; Rodríguez-Torres, Sergio A.; Saito, Shun; Salazar-Albornoz, Salvador; Schneider, Donald P.; Thomas, Daniel; Tinker, Jeremy; Tojeiro, Rita; Wang, Yuting; White, Martin; Zhao, Gong-bo

    2017-01-01

    We present baryon acoustic oscillation (BAO) scale measurements determined from the clustering of 1.2 million massive galaxies with redshifts 0.2 < z < 0.75 distributed over 9300 deg2, as quantified by their redshift-space correlation function. In order to facilitate these measurements, we define, describe, and motivate the selection function for galaxies in the final data release (DR12) of the SDSS III Baryon Oscillation Spectroscopic Survey (BOSS). This includes the observational footprint, masks for image quality and Galactic extinction, and weights to account for density relationships intrinsic to the imaging and spectroscopic portions of the survey. We simulate the observed systematic trends in mock galaxy samples and demonstrate that they impart no bias on BAO scale measurements and have a minor impact on the recovered statistical uncertainty. We measure transverse and radial BAO distance measurements in 0.2 < z < 0.5, 0.5 < z < 0.75, and (overlapping) 0.4 < z < 0.6 redshift bins. In each redshift bin, we obtain a precision that is 2.7 per cent or better on the radial distance and 1.6 per cent or better on the transverse distance. The combination of the redshift bins represents 1.8 per cent precision on the radial distance and 1.1 per cent precision on the transverse distance. This paper is part of a set that analyses the final galaxy clustering data set from BOSS. The measurements and likelihoods presented here are combined with others in Alam et al. to produce the final cosmological constraints from BOSS.

  16. Establishment of multi-site infection model in zebrafish larvae for studying Staphylococcus aureus infectious disease.

    PubMed

    Li, Ya-juan; Hu, Bing

    2012-09-20

    Zebrafish (Danio rerio) is an ideal model for studying the mechanism of infectious disease and the interaction between host and pathogen. As a teleost, zebrafish has developed a complete immune system which is similar to mammals. Moreover, the easy acquirement of large amounts of transparent embryos makes it a good candidate for gene manipulation and drug screening. In a zebrafish infection model, all of the site, timing, and dose of the bacteria microinjection into the embryo are important factors that determine the bacterial infection of host. Here, we established a multi-site infection model in zebrafish larvae of 36 hours post-fertilization (hpf) by microinjecting wild-type or GFP-expressing Staphylococcus aereus (S. aureus) with gradient burdens into different embryo sites including the pericardial cavity (PC), eye, the fourth hindbrain ventricle (4V), yolk circulation valley (YCV), caudal vein (CV), yolk body (YB), and Duct of Cuvier (DC) to resemble human infectious disease. With the combination of GFP-expressing S. aureus and transgenic zebrafish Tg (coro1a: eGFP; lyz: Dsred) and Tg (lyz: Dsred) lines whose macrophages or neutrophils are fluorescent labeled, we observed the dynamic process of bacterial infection by in vivo multicolored confocal fluorescence imaging. Analyses of zebrafish embryo survival, bacterial proliferation and myeloid cells phagocytosis show that the site- and dose-dependent differences exist in infection of different bacterial entry routes. This work provides a consideration for the future study of pathogenesis and host resistance through selection of multi-site infection model. More interaction mechanisms between pathogenic bacteria virulence factors and the immune responses of zebrafish could be determined through zebrafish multi-site infection model.

  17. Replication and Comparison of the Newly Proposed ADOS-2, Module 4 Algorithm in ASD without ID: A Multi-Site Study

    ERIC Educational Resources Information Center

    Pugliese, Cara E.; Kenworthy, Lauren; Bal, Vanessa Hus; Wallace, Gregory L.; Yerys, Benjamin E.; Maddox, Brenna B.; White, Susan W.; Popal, Haroon; Armour, Anna Chelsea; Miller, Judith; Herrington, John D.; Schultz, Robert T.; Martin, Alex; Anthony, Laura Gutermuth

    2015-01-01

    Recent updates have been proposed to the Autism Diagnostic Observation Schedule-2 Module 4 diagnostic algorithm. This new algorithm, however, has not yet been validated in an independent sample without intellectual disability (ID). This multi-site study compared the original and revised algorithms in individuals with ASD without ID. The revised…

  18. Observed Stellar Spectra As Templates For Gaia. I. The Asiago Red Clump Spectroscopic Survey At 1.22 Meter Telescope

    NASA Astrophysics Data System (ADS)

    Saguner, T.; Munari, U.; Vallenari, A.

    2011-02-01

    We aim to derive accurate, multi-epoch radial velocities and atmospheric parameters (Teff, log g and [M/H]) of a large sample of Red Clump stars. We acquired data of the target stars at high signal-to-noise (S/N) and medium resolution with the Asiago B&C spectrograph. Radial velocities were obtained by applying cross-correlation against observed IAU standard stars and atmospheric parameters via χ2 fit to a synthetic spectral library. Extensive tests were carried out with the multi-epoch observations of the programme stars and re-observations of the Red Clump stars that are taken from different catalogues in the literature. A total of 305 Red Clump stars (60 of them with a second epoch observation) were observed, and presented in an output catalogue that contains accurate radial velocities (σ(RV) = 2.6 km s-1), atmospheric parameters (σ(Teff) = 68 K, σ(log g) = 0.38 dex and σ([M/H]) = 0.17 dex), distances derived from spectrophotometry, space velocities (U,V,W) with additional astrometric and photometric data taken from literature. We aim to use our final catalogue to study the substructure and kinematics of the Galaxy.

  19. IMAGING AND SPECTROSCOPIC OBSERVATIONS OF A TRANSIENT CORONAL LOOP: EVIDENCE FOR THE NON-MAXWELLIAN κ-DISTRIBUTIONS

    SciTech Connect

    Dudík, Jaroslav; Mackovjak, Šimon; Dzifčáková, Elena; Karlický, Marian; Kotrč, Pavel; Fárník, František; Zemanová, Alena; Del Zanna, Giulio; Mason, Helen E.; Williams, David R.; Lörinčík, Juraj

    2015-07-10

    We report on the Solar Dynamics Observatory/Atmospheric Imaging Assembly (AIA) and Hinode/EUV Imaging Spectrograph (EIS) observations of a transient coronal loop. The loop brightens up in the same location after the disappearance of an arcade formed during a B8.9-class microflare 3 hr earlier. EIS captures this loop during its brightening phase, as observed in most of the AIA filters. We use the AIA data to study the evolution of the loop, as well as to perform the differential emission measure (DEM) diagnostics as a function of κ. The Fe xi–Fe xiii lines observed by EIS are used to perform the diagnostics of electron density and subsequently the diagnostics of κ. Using ratios involving the Fe xi 257.772 Å self-blend, we diagnose κ ≲ 2, i.e., an extremely non-Maxwellian distribution. Using the predicted Fe line intensities derived from the DEMs as a function of κ, we show that, with decreasing κ, all combinations of ratios of line intensities converge to the observed values, confirming the diagnosed κ ≲ 2. These results represent the first positive diagnostics of κ-distributions in the solar corona despite the limitations imposed by calibration uncertainties.

  20. High-dispersion spectroscopic observations of Venus during 1968 and 1969 II. The carbon-dioxide band at 8689A

    NASA Technical Reports Server (NTRS)

    Schorn, R. A. J.; Woszczyk, A.; Young, L. D. G.

    1974-01-01

    Thirty well-exposed photographic plates showing the spectrum of the carbon dioxide band at 8689A in the atmosphere of Venus were obtained during 1968 and 1969. All spectra were obtained at a dispersion of 2 A/mm for Venus phase angles varying from 10 deg. to 126 deg. Rotational temperatures ranging from 236 K to 274 K were found. The average value of the rotational temperature is 246 + or - 1 K (one standard deviation); for 1967 observations, the rotational temperatures ranged from 222 to 248 K, with an average value of 238 + or - 4 K. The variation of the equivalent width of the 8689A band, with Venus phase angle, was very similar for the two sets of observations (53 plates). The temporal variations, of approximately 30 percent, were comparable with the phase variations over this limited range of phase angle.

  1. Thermal infrared spectroscopic observations of Mars from the Kuiper Airborne Observatory (KAO): Constraints on past climates and weathering products

    NASA Technical Reports Server (NTRS)

    Roush, Ted L.; Pollack, James B.; Witteborn, Fred C.; Bregman, Jesse D.; Bell, James F., III; Sitton, Bradley

    1995-01-01

    Spectral observations providing evidence for the presence of volatile-bearing minerals on the surface of Mars were obtained in 1988 and 1990 from the KAO. The 1988 data suggest the presence of 1-3 weight percent (wt%) of carbonate/bicarbonate and 10-15 wt% sulfate/bisulfate associated with martian atmospheric dust. Estimates of the optical depths are approximately 0.60 and approximately 0.35 in 1988 and 1990, respectively.

  2. The vertical structure of the Uranian atmosphere near equinox as modeled with near-infrared spectroscopic observations

    NASA Astrophysics Data System (ADS)

    Norwood, James Walter

    We acquired spectra of Uranus in September 2006 and September 2007, at NASA's infrared Telescope Facility using the spectrograph SpeX. These spectra from 0.8--2.5 mum allow probing the Uranian troposphere due to the low haze opacity and broad range in methane opacity in the near infrared. Our observations occurred close to Uranus' December 2007 equinox, which not only allowed us to simultaneously observe regions of constant latitude due to the near-zero sub-observer latitude, but also provided a rare opportunity to study Uranus in one of the extremes of its 84-year seasonal cycle. We modeled the vertical structure of the Uranian atmosphere with a radiative transfer code designed to generate synthetic spectra based on a given set of atmospheric properties, for comparison with our observations. We employed the band-model methane absorption coefficients of Irwin et al. (2006), determined the effects of collision-induced absorption, and accounted for the large spatial coverage in each observation by calculating the contributions of numerous locations on Uranus to each spectrum. Our models assumed three aerosol layers in the atmosphere of Uranus: a stratospheric haze layer, and two tropospheric cloud layers. We fit optimum values to the optical depth of each aerosol layer in different spectral regions and to the pressure levels of each cloud layer; holding all other parameters constant. Our model results described two overarching regimes on Uranus. In 2006, the spectra from the southern hemisphere were best fit with bright clouds at high altitude, while the northern hemisphere was characterized by a dimmer haze layer, almost nonexistent upper cloud, and a deep lower cloud near 7 bars. However, this changed in the one-year interim between our data sets. In 2007, the high-cloud regions were instead around the equator, and we found the region near 45°S, which in previous years had displayed a bright polar collar, to have taken on the characteristics of the dimmer deeper

  3. {sup 13}C-METHYL FORMATE: OBSERVATIONS OF A SAMPLE OF HIGH-MASS STAR-FORMING REGIONS INCLUDING ORION-KL AND SPECTROSCOPIC CHARACTERIZATION

    SciTech Connect

    Favre, Cécile; Bergin, Edwin A.; Crockett, Nathan R.; Neill, Justin L.; Carvajal, Miguel; Field, David; Jørgensen, Jes K.; Bisschop, Suzanne E.; Brouillet, Nathalie; Despois, Didier; Baudry, Alain; Kleiner, Isabelle; Margulès, Laurent; Huet, Thérèse R.; Demaison, Jean E-mail: miguel.carvajal@dfa.uhu.es

    2015-01-01

    We have surveyed a sample of massive star-forming regions located over a range of distances from the Galactic center for methyl formate, HCOOCH{sub 3}, and its isotopologues H{sup 13}COOCH{sub 3} and HCOO{sup 13}CH{sub 3}. The observations were carried out with the APEX telescope in the frequency range 283.4-287.4 GHz. Based on the APEX observations, we report tentative detections of the {sup 13}C-methyl formate isotopologue HCOO{sup 13}CH{sub 3} toward the following four massive star-forming regions: Sgr B2(N-LMH), NGC 6334 IRS 1, W51 e2, and G19.61-0.23. In addition, we have used the 1 mm ALMA science verification observations of Orion-KL and confirm the detection of the {sup 13}C-methyl formate species in Orion-KL and image its spatial distribution. Our analysis shows that the {sup 12}C/{sup 13}C isotope ratio in methyl formate toward the Orion-KL Compact Ridge and Hot Core-SW components (68.4 ± 10.1 and 71.4 ± 7.8, respectively) are, for both the {sup 13}C-methyl formate isotopologues, commensurate with the average {sup 12}C/{sup 13}C ratio of CO derived toward Orion-KL. Likewise, regarding the other sources, our results are consistent with the {sup 12}C/{sup 13}C in CO. We also report the spectroscopic characterization, which includes a complete partition function, of the complex H{sup 13}COOCH{sub 3} and HCOO{sup 13}CH{sub 3} species. New spectroscopic data for both isotopomers H{sup 13}COOCH{sub 3} and HCOO{sup 13}CH{sub 3}, presented in this study, have made it possible to measure this fundamentally important isotope ratio in a large organic molecule for the first time.

  4. CCD system upgrading of the Kyoto3DII and integral field spectroscopic observation with the new system

    NASA Astrophysics Data System (ADS)

    Mitsuda, Kazuma; Hashiba, Yasuhito; Minowa, Yosuke; Hayano, Yutaka; Sugai, Hajime; Shimono, Atsushi; Matsubayashi, Kazuya; Hattori, Takashi; Kamata, Yukiko; Ozaki, Shinobu; Doi, Mamoru; Sako, Shigeyuki

    2016-08-01

    The Kyoto Tridimensional Spectrograph II (Kyoto 3DII) is an optical integral field spectrograph mounted on the Subaru telescope as a PI-type instrument. Used with AO188, Kyoto 3DII provides us unique opportunities of optical Integral Field Spectroscopy (IFS) with adaptive optics (AO). While AO works better in redder wavelength regions, quantum efficiency of the previous CCD was low there with optimization for a wider wavelength coverage. To optimize Kyoto 3DII to AO observations, we have newly installed the red-sensitive Hamamatsu fully depleted CCD, which enhances the system efficiency by a factor of 2 in the red wavelength range. Fringes are dramatically reduced, and the readout noise drops to 3:2-3:4e- about two times smaller than previous, due to refrigerator and readout system. With these improvements, we carried out engineering and scientific observations in September 2015, February and March 2016. We measured the system efficiency using a standard star, and confirmed the successful improvement of the system efficiency. We observed galactic nuclei of nearby galaxies in the Natural Guide Star (NGS) and the Laser Guide Star (LGS) modes. We found the spatial resolution of 0.1'' FWHM using a 9.5-magnitude NGS, and 0.2 - 0:4'' in LGS mode. Together with the AO resolution, improved efficiency opens a new window for Kyoto 3DII to carry out high resolution optical IFS targeting faint objects such as high-redshift galaxies as well as faint lines such as [OI] λ6300° A and absorption lines of nearby objects.

  5. Spectroscopic determinations of surface gravities of giant stars, and ultraviolet observations of RR Lyrae and X Arietis

    SciTech Connect

    Bonnell, J.T.

    1987-01-01

    The surface gravities of four K giant stars, including the well-known standard stars Arcturus (..cap alpha.. Boo) and Aldebaran (..cap alpha.. Tau) were determined from an analysis of the molecular dissociation equilibrium of OH. High-resolution FTS spectra of the infrared ground-state vibration-rotation lines of the OH ..delta..v = 1 and ..delta.. v = 2 sequences were used in the analysis. The oxygen abundances were derived from the (O I) lines at 6300 and 6363 A. The surface gravities of 5 further G and K giants were determined from an analysis of the molecular equilibrium of MgH, the magnesium abundances being derived from visible and near-infrared high-excitation-potential MgI lines. Ultraviolet observations of RR Lyrae and X Arietis obtained with the Astronomical Netherlands Satellite (ANS) and the International Ultraviolet Explorer (IUE) satellite are also discussed. These observations are compared with light curves derived using model atmospheres and synthetic spectrum calculations in conjunction with angular diameters determined by Manduca et al. (1981) from photometry at longer wavelengths. A good agreement is found.

  6. Spectroscopic determinations of surface gravities of giant stars, and ultraviolet observations of RR Lyrae and X ARIETIS

    NASA Astrophysics Data System (ADS)

    Bonnell, Jeremiah Tighe

    The surface gravities of four giant K stars, including the well known standard stars Arcturus (alpha Boo) and Aldebaran (alpha Tau) are determined from an analysis of the molecular dissociation equilibrium of OH. High resolution FTS spectra of the infrared ground state vibration-rotation lines of the OH delta v = 1 and delta v = 2 sequences were used in the analysis. The oxygen abundances were derived from the (OI) line at 6300 and 6363 A. Lifetimes for the OH delta v = 2 sequence lines are derived based on the electric dipole moment function and rotationless Einstein A values. Masses for the stars based on the derived gravities, measured parallaxes, and angular diameters are discussed. The surface gravities of 5 more G and K giants were determined from an analysis of the molecular equilibrium of MgH, the magnesium abundances being derived from visible and near infrared high excitation potential MgI lines. The MgH/MgI gravities are compared to surface gravities derived based on an analysis of the ionization equilibrium of iron. It is found that the implied giant star masses are not significantly subsolar. Ultraviolet observations of RR Lyrae and X Arietis obtained with the Astronomical Netherlands Satellite (ANS) and the International Ultraviolet Explorer (IUE) satellite are also discussed. These observations are compared with light curves derived using model atmospheres and synthetic spectrum calculations in conjunction with angular diameters determined from photometry at longer wavelengths. A good agreement was found.

  7. A new method of observing weak extended x-ray sources with the Reuven Ramaty high-energy solar spectroscopic imager.

    PubMed

    Hannah, Iain G; Hurford, Gordon J; Hudson, Hugh S; Lin, Robert P

    2007-02-01

    We present a new method, fan-beam modulation, for observing weak extended x-ray sources with the Reuven Ramaty High-Energy Solar Spectroscopic Imager (RHESSI). This space-based solar x-ray and gamma-ray telescope has much greater sensitivity than previous experiments in the 3-25 keV range, but is normally not well suited to detecting extended sources since their signal is not modulated by RHESSI's rotating grids. When the spacecraft is offpointed from the target source, however, the fan-beam modulation time-modulates the transmission by shadowing resulting from exploiting the finite thickness of the grids. In this article we detail how the technique is implemented and verify its consistency with sources with clear known signals that have occurred during RHESSI offpointing: microflares and the Crab Nebula. In both cases the results are consistent with previous and complementary measurements. Preliminary work indicates that this new technique allows RHESSI to observe the integrated hard x-ray spectrum of weak extended sources on the quiet Sun.

  8. First spectroscopic observation of gold(i) butadiynylide: Photodetachment velocity map imaging of the AuC4H anion.

    PubMed

    Visser, Bradley R; Addicoat, Matthew A; Gascooke, Jason R; Lawrance, Warren D; Metha, Gregory F

    2016-07-28

    The velocity map imaging technique was used in the investigation of gold(i) butadiynylide, AuC4H(-), with images recorded at two excitation wavelengths. The resultant photodetachment spectra show a well defined vibrational progression in the neutral with an energy spacing of 343 ± 3 cm(-1). The adiabatic electron affinity was determined to be 1.775 ± 0.005 eV and assigned to the X(1)Σ(+)←X(2)Σ(+) transition between the anionic and neutral ground states. Franck-Condon simulations performed on density functional theory optimized geometries assisted the assignment of linear geometries to the neutral and anion and the observed vibrational progression to that of the Au-C4H stretch.

  9. First spectroscopic observation of gold(i) butadiynylide: Photodetachment velocity map imaging of the AuC4H anion

    NASA Astrophysics Data System (ADS)

    Visser, Bradley R.; Addicoat, Matthew A.; Gascooke, Jason R.; Lawrance, Warren D.; Metha, Gregory F.

    2016-07-01

    The velocity map imaging technique was used in the investigation of gold(i) butadiynylide, AuC4H-, with images recorded at two excitation wavelengths. The resultant photodetachment spectra show a well defined vibrational progression in the neutral with an energy spacing of 343 ± 3 cm-1. The adiabatic electron affinity was determined to be 1.775 ± 0.005 eV and assigned to the X1Σ+←X2Σ+ transition between the anionic and neutral ground states. Franck-Condon simulations performed on density functional theory optimized geometries assisted the assignment of linear geometries to the neutral and anion and the observed vibrational progression to that of the Au-C4H stretch.

  10. Pulsation in the atmosphere of the roAp star HD 24712. I. Spectroscopic observations and radial velocity measurements

    NASA Astrophysics Data System (ADS)

    Ryabchikova, T.; Sachkov, M.; Weiss, W. W.; Kallinger, T.; Kochukhov, O.; Bagnulo, S.; Ilyin, I.; Landstreet, J. D.; Leone, F.; Lo Curto, G.; Lüftinger, T.; Lyashko, D.; Magazzù, A.

    2007-02-01

    Aims:We have investigated the structure of the pulsating atmosphere of one of the best studied rapidly oscillating Ap stars, HD 24712. Methods: For this purpose we analyzed spectra collected during 2001-2004. An extensive data set was obtained in 2004 simultaneously with the photometry of the Canadian MOST mini-satellite. This allows us to connect directly atmospheric dynamics observed as radial velocity variations with light variations seen in photometry. Results: We directly derived for the first time and for different chemical elements, respectively ions, phase shifts between photometric and radial velocity pulsation maxima indicating, as we suggest, different line formation depths in the atmosphere. This allowed us to estimate for the first time the propagation velocity of a pulsation wave in the outer stellar atmosphere of a roAp star to be slightly lower than the sound speed. We confirm large pulsation amplitudes (150-400 m s-1) for REE lines and the Hα core, while spectral lines of the other elements (Mg, Si, Ca, and Fe-peak elements) have nearly constant velocities. We did not find different pulsation amplitudes and phases for the lines of rare-earth elements before and after the Balmer jump, which supports the hypothesis of REE concentration in the upper atmosphere above the hydrogen line-forming layers. We also discuss radial velocity amplitudes and phases measured for individual spectral lines as tools for a 3D tomography of the atmosphere of HD 24712. Based on observations collected at the Canada-France-Hawaii Telescope (CFHT), at the Nordic Optical Telescope (NOT), at the European Southern Observatory, Paranal, Chile, (DDT-274.D-5011), at the Telescopio Nazionale Galileo (TNG), and from MOST, a Canadian Space Agency mission operated jointly by Dynacon, Inc., the University of Toronto Institute of Aerospace Studies, and the University of British Columbia, with assistance from the University of Vienna. Tables 4, 5 and Fig. 9 are only available in

  11. Far Ultraviolet Spectroscopic Explorer and Space Telescope Imaging Spectrograph Observations of Intervening O VI Absorption Line Systems in the Spectrum of PG 0953+415

    NASA Astrophysics Data System (ADS)

    Savage, B. D.; Sembach, K. R.; Tripp, T. M.; Richter, P.

    2002-01-01

    We present Far Ultraviolet Spectroscopic Explorer (FUSE) and Space Telescope Imaging Spectrograph (STIS) observations of the intergalactic medium toward the bright QSO PG 0953+415 (zem=0.239). The FUSE spectra extend from 905 to 1187 Å and have a resolution of 25 km s-1, while the STIS spectra cover 1150-1730 Å and have a resolution of 7 km s-1. Additional STIS observations at 30 km s-1 are obtained in selected wavelength ranges. An O VI system at z=0.06807 is detected in H I Lyα, Lyβ, Lyγ, O VI λλ1031.93, 1037.62, N V λλ1238.82, 1242.80, C IV λλ1548.20, 1550.77, and C III λ977.02. The observed column densities can be modeled as a low-density intervening gas with a metallicity of 0.4+0.6-0.2 times solar in photoionization equilibrium with the ionizing extragalactic background radiation. The best fit is achieved with an ionization parameter, logU=-1.35, which implies nH~10-5 cm-3 and a path length of ~80 kpc through the absorbing gas. H I Lyα absorption at z=0.14232 spans a velocity range of 410 km s-1 with the strongest components near 0 and 80 km s-1 in the z=0.14232 rest frame. In this system, O VI λλ1031.93, 1037.62 absorption is strong near 0 km s-1 and not detected at 80 km s-1. C III λ977.02 absorption is marginally detected at 80 km s-1 but is not detected at 0 km s-1. The observations place constraints on the properties of the z=0.14232 system but do not discriminate between collisional ionization in hot gas versus photoionization in a very low density medium with an ionization parameter logU>-0.74. The z=0.06807 and 0.14232 O VI systems occur at redshifts where there are peaks in the number density of intervening galaxies along the line of sight determined from WIYN redshift measurements of galaxies in the ~1° field centered on PG 0953+415. We combine our observations of PG 0953+415 with those for other QSOs to update the estimate of the low-redshift number density of intervening O VI systems. Over a total unobscured redshift path of Δz=0

  12. VLT/GIRAFFE spectroscopic observations of the metal-poor blue compact dwarf galaxy SBS 0335-052E

    NASA Astrophysics Data System (ADS)

    Izotov, Y. I.; Schaerer, D.; Blecha, A.; Royer, F.; Guseva, N. G.; North, P.

    2006-11-01

    Aims.We present two-dimensional spectroscopy of the extremely metal-deficient blue compact dwarf (BCD) galaxy SBS 0335-052E to study physical conditions, element abundances and kinematical properties of the ionised gas in this galaxy. Methods: .Observations were obtained in the spectral range λ3620-9400 Å with the imaging spectrograph GIRAFFE on the UT2 of the Very Large Telescope (VLT). These observations are the first ones carried out so far with GIRAFFE in the ARGUS mode which allows one to simultaneously obtain 308 spectra covering a 11.4 arcsec×7.3 arcsec region. Results: .We produced images of SBS 0335-052E in the continuum and in emission lines of different stages of excitation. While the maximum of emission in the majority of lines, including the strong lines Hβ 4861 Å, Hα 6563 Å, [O iii] 4363,5007 Å, [O ii] 3726,3729 Å, coincides with the youngest south-eastern star clusters 1 and 2, the emission of He II 4686 Å line is offset to the more evolved north-west clusters 4, 5. This suggests that hard ionising radiation responsible for the He II λ4686 Å emission is not related to the most massive youngest stars, but rather is related to fast radiative shocks. This conclusion is supported by the kinematical properties of the ionised gas from the different emission lines as the velocity dispersion in the He II λ4686 Å line is systematically higher, by ~50-100%, than that in other lines. The variations of the emission line profiles suggest the presence of an ionised gas outflow in the direction perpendicular to the galaxy disk. We find a relatively high electron number density Ne of several hundred cm-3 in the brightest part of SBS 0335-052E. There is a small gradient of the electron temperature Te and oxygen abundance from the East to the West with systematically higher Te and lower 12+log O/H in the western part of the galaxy. The oxygen abundances for the whole H II region and its brightest part are 12 + log O/H = 7.29 ± 0.02 and 7.31 ± 0

  13. Predicting multisite protein subcellular locations: progress and challenges.

    PubMed

    Du, Pufeng; Xu, Chao

    2013-06-01

    In the last two decades, predicting protein subcellular locations has become a hot topic in bioinformatics. A number of algorithms and online services have been developed to computationally assign a subcellular location to a given protein sequence. With the progress of many proteome projects, more and more proteins are annotated with more than one subcellular location. However, multisite prediction has only been considered in a handful of recent studies, in which there are several common challenges. In this special report, the authors discuss what these challenges are, why these challenges are important and how the existing studies gave their solutions. Finally, a vision of the future of predicting multisite protein subcellular locations is given.

  14. Security architecture for multi-site patient records research.

    PubMed Central

    Behlen, F. M.; Johnson, S. B.

    1999-01-01

    A security system was developed as part of a patient records research database project intended for both local and multi-site studies. A comprehensive review of ethical foundations and legal environment was undertaken, and a security system comprising both administrative policies and computer tools was developed. For multi-site studies, Institutional Review Board (IRB) approval is required for each study, at each participating site. A sponsoring Principal Investigator (PI) is required at each site, and each PI needs automated enforcement tools. Systems fitting this model were implemented at two academic medical centers. Security features of commercial database systems were found to be adequate for basic enforcement of approved research protocols. PMID:10566404

  15. Independent positioning of microelectrodes for multisite recordings in vitro.

    PubMed

    Albus, Klaus; Sinske, Kurt; Heinemann, Uwe

    2009-01-30

    A robust and easy to handle, inexpensive multisite recording system is described which allows independent positioning of several microelectrodes with high precision axial movement of each electrode. The basic units of the system are a manually operated manipulator for left-right and up-down movement and a micrometer for positioning in the direction of the micrometer axis. The micrometer is actuated with a DC-motor operated by a stand-alone controller module allowing for remote control of the motor in either step mode or continuous mode. The multisite recording system has been proven to allow stable simultaneous recordings of single unit and population activities, extracellular ion concentrations and intracellular potentials in organotypic hippocampal slice cultures (OHSCs) of rat.

  16. NGP: a new large format infrared detector for observation, hyperspectral and spectroscopic space missions in VISIR, SWIR and MWIR wavebands

    NASA Astrophysics Data System (ADS)

    Delannoy, Anne; Fièque, Bruno; Chorier, Philippe; Riuné, Céline

    2015-10-01

    SOFRADIR is one of the leading companies involved in the development and manufacturing of infrared detectors for space applications. As a matter of fact, SOFRADIR is present in many space programs in visible and SWIR spectral ranges. Most of these programs concern hyperspectral imagery observation of the earth but also some scientific applications. For more than 10 years, the Saturn generation detector (VISIR or SWIR) of Sofradir was the basis of numerous space missions. In order to answer future mission needs which require larger detector for better spatial and spectral resolutions while complying with all specifications reflecting the state of requirements for space detectors, SOFRADIR has developed a new detector in a frame of an ESA R and T program, named Next Generation Panchromatic Detector (NGP). While designed for VISIR and SWIR spectral ranges, this detector is also studied to be extended in MWIR spectral range. In this paper, NGP detector will be described as well as its performances. Space applications using this detector will be presented also showing appropriateness of its use to answer space programs specifications, as for example those of Sentinel-5.

  17. Photometric and Spectroscopic Observations of Gaia16cfr/AT 2016jbu: A Probable Supernova Impostor in NGC 2442

    NASA Astrophysics Data System (ADS)

    Bose, S.; Monard, L. A. G.; Seidel, M. K.; Dong, S.; Hsiao, E.; Shappee, B. J.; Bond, H. E.; Prieto, J. L.; Morrell, N.; Phillips, M.

    2017-01-01

    Gaia16cfr/AT 2016jbu was discovered by Gaia Alerts at 19.6 mag on UT 2016-12-01 (http://gsaweb.ast.cam.ac.uk/alerts/alert/Gaia16cfr/). This transient in NGC 2442 was also found by Berto Monard at 17.8 +/- 0.2 mag (clear filter) on UT 2016-12-22.85, and the photometric observations by Monard from 2016-12-22 to 2017-01-01 are listed below: Time (UT) Mag (clear filter) -------------------- 2016-12-22.85 17.8 +/- 0.2 2016-12-30.88 17.7 +/- 0.1 2016-12-31.96 17.7 +/- 0.1 2017-01-01.87 17.4 +/- 0.2 The distance NGC 2442 (z = 0.0049) is estimated as 23.9 +/- 0.4 Mpc using SN Ia 2015F (Im et al., 2015), and the absolute magnitude of Gaia16cfr/AT 2016jbu on 2017-01-01.87 is thus about -14.5 mag without taking into account of extinction (the Galactic extinction is about A_R 0.4 mag according to NED).

  18. Fast-ion deuterium alpha spectroscopic observations of the effects of fishbones in the Mega-Ampere Spherical Tokamak

    NASA Astrophysics Data System (ADS)

    Jones, O. M.; Michael, C. A.; McClements, K. G.; Conway, N. J.; Crowley, B.; Akers, R. J.; Lake, R. J.; Pinches, S. D.; the MAST Team

    2013-08-01

    Using the recently installed fast-ion deuterium alpha (FIDA) spectrometer, the effects of low-frequency (20-50 kHz) chirping energetic particle modes with toroidal mode number n ⩾ 1 on the neutral beam injection-driven fast-ion population in Mega-Ampere Spherical Tokamak (MAST) plasmas are considered. Results from the FIDA diagnostic are presented and discussed in the light of the present theoretical understanding of these modes, known as fishbones, in plasmas with reversed shear. Measurements of the fast-ion population reveal strong redistribution of fast ions in both real and velocity space as a result of the fishbones. Time-resolved measurements throughout the evolution of a fishbone show radial redistribution of fast ions with energies up to 95% of the primary beam injection energy. Correlations between changes in the FIDA signal and the peak time derivative of the magnetic field perturbation are observed in a limited range of operating scenarios. The transient reduction in signal caused by a fishbone may in some cases reach 50% of the signal intensity before mode onset.

  19. High-dispersion spectroscopic observations of comet C/2013 R1 (Lovejoy) with the Subaru Telescope on 2013 November 15

    NASA Astrophysics Data System (ADS)

    Shinnaka, Y.; Kawakita, H.; Nagashima, M.; Kobayashi, H.; Decock, A.; Jehin, E.

    2014-07-01

    Comet C/2013 R1 (Lovejoy) probably originates from the Oort Cloud. Comet Lovejoy provided us with great opportunities to investigate the chemical composition of the comet thanks to its brightness and elongation angle from October 2013 to March 2014. We observed comet C/2013 R1 (Lovejoy) on 2013 November 15 UT using the High Dispersion Spectrograph (HDS) mounted on the Subaru Telescope on Mauna Kea. Its heliocentric and geocentric distances were 1.066 and 0.412 au, respectively. The obtained spectra cover the wavelength region from 360 to 830 nm with the resolving power of R = λ/Δλ = 72,000 for the slit size of 0''.5 × 9''.0 (360-520 nm) and 0''.5 × 9''.0 (550-830 nm) on the sky. Exposure time was 130 minutes in total (100 minutes for shorter and 30 minutes for longer wavelength regions). We could identify many species such as the radicals (CN, CH, C_{3}, C_{2}, NH_{2}, etc.), ions (CH^{+}, H_{2}O^{+}), and atoms ([OI] and NaI) in the spectra and many unidentified lines were also detected. Here we discuss the chemical reaction in cometary coma and the origin of icy materials of comet C/2013 R1 (Lovejoy), based on the high-dispersion spectra in the optical wavelength regions. We present (1) the ortho-to-para abundance ratios (OPRs) of water and ammonia inferred from the high-dispersion spectra of H_{2}O^{+} and NH_{2}, (2) the green-to-red line ratio of forbidden oxygen emissions, (3) the nitrogen and the carbon isotopic ratios of CN, and (4) spatial distributions of radicals, atoms, and dust continuum in the inner coma.

  20. Spectroscopic observations of active solar-analog stars with high X-ray luminosity, as a proxy of superflare stars

    NASA Astrophysics Data System (ADS)

    Notsu, Yuta; Honda, Satoshi; Maehara, Hiroyuki; Notsu, Shota; Namekata, Kosuke; Nogami, Daisaku; Shibata, Kazunari

    2017-02-01

    Recent studies of solar-type superflare stars have suggested that even old slowly rotating stars similar to the Sun can have large starspots and superflares. We conducted high-dispersion spectroscopy of 49 nearby solar-analog stars (G-type main-sequence stars with Teff ≈ 5600-6000 K) identified as ROSAT soft X-ray sources, which are not binary stars from previous studies. We expected that these stars could be used as a proxy of bright solar-analog superflare stars, since superflare stars are expected to show strong X-ray luminosity. More than half (37) of the 49 target stars show no evidence of binarity, and their atmospheric parameters (temperature, surface gravity, and metallicity) are within the range of ordinary solar-analog stars. We measured the intensity of Ca II 8542 and Hα lines, which are good indicators of the stellar chromospheric activity. The intensity of these lines indicates that all the target stars have large starspots. We also measured v sin i (projected rotational velocity) and lithium abundance for the target stars. Li abundance is a key to understanding the evolution of the stellar convection zone, which reflects the stellar age, mass and rotational history. We confirmed that many of the target stars rapidly rotate and have high Li abundance, compared with the Sun, as suggested by many previous studies. There are, however, also some target stars that rotate slowly (v sin i = 2-3 km s-1) and have low Li abundance like the Sun. These results support that old and slowly rotating stars similar to the Sun could have high activity levels and large starspots. This is consistent with the results of our previous studies of solar-type superflare stars. In the future, it is important to conduct long-term monitoring observations of these active solar-analog stars in order to investigate detailed properties of large starspots from the viewpoint of stellar dynamo theory.

  1. Proton adsorption onto alumina: extension of multisite complexation (MUSIC) theory

    SciTech Connect

    Nagashima, K.; Blum, F.D.

    1999-09-01

    The adsorption isotherm of protons onto a commercial {gamma}-alumina sample was determined in aqueous nitric acid with sodium nitrate as a background electrolyte. Three discrete regions could be discerned in the log-log plots of the proton isotherm determined at the solution pH 5 to 2. The multisite complexation (MUSIC) model was modified to analyze the simultaneous adsorption of protons onto various kinds of surface species.

  2. Multisite artery disease: a common and challenging clinical condition calling for specific management.

    PubMed

    Di Noi, Paola; Brancati, Marta Francesca; Burzotta, Francesco; Trani, Carlo

    2014-05-01

    'Multisite' artery disease is defined as the simultaneous presence of clinically significant atherosclerotic lesions in at least two major vascular territories. The management of patients with multisite artery disease represents a common challenge in clinical practice, since they are at increased risk for both vascular and coronary surgery. Preliminary experiences suggest that percutaneous treatment may represent a promising strategy for patients with multisite artery disease. In this review, the prevalence and management of multisite artery disease are discussed with particular attention to coronary and peripheral revascularization related issues.

  3. Observational and laboratory studies of optical properties of black and brown carbon particles in the atmosphere using spectroscopic techniques

    NASA Astrophysics Data System (ADS)

    Nakayama, Tomoki; Matsumi, Yutaka

    2015-04-01

    Light absorption and scattering by aerosols are as an important contributor to radiation balance in the atmosphere. Black carbon (BC) is considered to be the most potent light absorbing material in the visible region of the spectrum, although light absorbing organic carbon (brown carbon or BrC) and mineral dust may also act as sources of significant absorption, especially in the ultraviolet (UV) and shorter visible wavelength regions. The optical properties of such particles depend on wavelength, particle size and shape, morphology, coating, and complex refractive index (or chemical composition), and therefore accurate in situ measurements of the wavelength dependence of the optical properties of particles are needed. Recently, cavity ring-down spectroscopy (CRDS) and photoacoustic spectroscopy (PAS) have been used for the direct measurements of extinction and absorption coefficients of particles suspended in air. We have applied these techniques to the observational studies of optical properties of BC and BrC in an urban site in Japan and to the laboratory studies of optical properties of secondary organic aerosols (SOAs) generated from a variety of biogenic and anthropogenic volatile organic compounds and those of diesel exhaust particles (DEPs). In the presentation, the basic principles of these techniques and the results obtained in our studies and in the recent literatures will be overviewed. References Guo, X. et al., Measurement of the light absorbing properties of diesel exhaust particles using a three-wavelength photoacoustic spectrometer, Atmos. Environ., 94, 428-437 (2014). Nakayama, T. et al., Measurements of aerosol optical properties in central Tokyo during summertime using cavity ring-down spectroscopy: Comparison with conventional techniques, Atmos. Environ., 44, 3034-3042 (2010). Nakayama, T. et al., Laboratory studies on optical properties of secondary organic aerosols generated during the photooxidation of toluene and the ozonolysis of alpha

  4. Study of diatoms/aqueous solution interface. I. Acid-base equilibria and spectroscopic observation of freshwater and marine species

    NASA Astrophysics Data System (ADS)

    Gélabert, A.; Pokrovsky, O. S.; Schott, J.; Boudou, A.; Feurtet-Mazel, A.; Mielczarski, J.; Mielczarski, E.; Mesmer-Dudons, N.; Spalla, O.

    2004-10-01

    This work reports on a concerted study of diatom-water interfaces for two marine planktonic ( Thalassiosira weissflogii= TW, Skeletonema costatum= SC) and two freshwater periphytic species ( Achnanthidium minutissimum= AMIN, Navicula minima= NMIN). Proton surface adsorption was measured at 25°C, pH of 3 to 11 and ionic strength of 0.001 to 1.0 M via potentiometric titration using a limited residence time reactor. Electrophoretic mobility of living cells and their frustules was measured as a function of pH and ionic strength. Information on the chemical composition and molecular structure of diatoms surfaces was obtained using FT-IR (in situ attenuated total reflectance) and X-ray Photoelectron Spectroscopy (XPS). The surface area of living cells and their frustules in aqueous solutions was quantified using Small Angle X-ray Scattering Spectroscopy (SAXS). These observations allowed us to identify the nature and to determine the concentration of the major surface functional groups (carboxyl, amine and silanol) responsible for the amphoteric behavior of cell surfaces in aqueous solutions. Taking into account the relative proportion of surface sites inferred from XPS and FT-IR measurements, a surface complexation model of diatom-solution interfaces was generated on the basis of surface titration results. The cell-normalized ratios of the three major surface sites {>COOH}: {>NH 3}: {>SiOH} are 1:1:0.1, 1:10:0, 1:1:0.4 and 1:1:0.3 for TW, SC, AMIN and NMIN, respectively. The total amount of proton/hydroxyl active surface sites for investigated species ranges from 1 (NMIN) to 9 (SC) mmol/g dry weight. Normalization of these site densities to the area of siliceous skeleton yields values between 0.3 (NMIN) and 0.9 mmol/m 2 (SC) which are an order of magnitude higher than corresponding values for organic-free frustules or amorphous silica. This suggests that the amphoteric properties and possibly the affinity for metal adsorption of diatom cultures are essentially

  5. Expansion of the gateway multisite recombination cloning toolkit.

    PubMed

    Shearin, Harold K; Dvarishkis, Alisa R; Kozeluh, Craig D; Stowers, R Steven

    2013-01-01

    Precise manipulation of transgene expression in genetic model organisms has led to advances in understanding fundamental mechanisms of development, physiology, and genetic disease. Transgene construction is, however, a precondition of transgene expression, and often limits the rate of experimental progress. Here we report an expansion of the modular Gateway MultiSite recombination-cloning platform for high efficiency transgene assembly. The expansion includes two additional destination vectors and entry clones for the LexA binary transcription system, among others. These new tools enhance the expression levels possible with Gateway MultiSite generated transgenes and make possible the generation of LexA drivers and reporters with Gateway MultiSite cloning. In vivo data from transgenic Drosophila functionally validating each novel component are presented and include neuronal LexA drivers, LexAop2 red and green fluorescent synaptic vesicle reporters, TDC2 and TRH LexA, GAL4, and QF drivers, and LexAop2, UAS, and QUAS channelrhodopsin2 T159C reporters.

  6. Multisite Ion Model in Concentrated Solutions of Divalent Cations (MgCl2 and CaCl2): Osmotic Pressure Calculations

    PubMed Central

    2015-01-01

    Accurate force field parameters for ions are essential for meaningful simulation studies of proteins and nucleic acids. Currently accepted models of ions, especially for divalent ions, do not necessarily reproduce the right physiological behavior of Ca2+ and Mg2+ ions. Saxena and Sept (J. Chem. Theor. Comput.2013, 9, 3538–3542) described a model, called the multisite-ion model, where instead of treating the ions as an isolated sphere, the charge was split into multiple sites with partial charge. This model provided accurate inner shell coordination of the ion with biomolecules and predicted better free energies for proteins and nucleic acids. Here, we expand and refine the multisite model to describe the behavior of divalent ions in concentrated MgCl2 and CaCl2 electrolyte solutions, eliminating the unusual ion–ion pairing and clustering of ions which occurred in the original model. We calibrate and improve the parameters of the multisite model by matching the osmotic pressure of concentrated solutions of MgCl2 to the experimental values and then use these parameters to test the behavior of CaCl2 solutions. We find that the concentrated solutions of both divalent ions exhibit the experimentally observed behavior with correct osmotic pressure, the presence of solvent separated ion pairs instead of direct ion pairs, and no aggregation of ions. The improved multisite model for (Mg2+ and Ca2+) can be used in classical simulations of biomolecules at physiologically relevant salt concentrations. PMID:25482831

  7. Multisite ion model in concentrated solutions of divalent cations (MgCl2 and CaCl2): osmotic pressure calculations.

    PubMed

    Saxena, Akansha; García, Angel E

    2015-01-08

    Accurate force field parameters for ions are essential for meaningful simulation studies of proteins and nucleic acids. Currently accepted models of ions, especially for divalent ions, do not necessarily reproduce the right physiological behavior of Ca(2+) and Mg(2+) ions. Saxena and Sept (J. Chem. Theor. Comput. 2013, 9, 3538-3542) described a model, called the multisite-ion model, where instead of treating the ions as an isolated sphere, the charge was split into multiple sites with partial charge. This model provided accurate inner shell coordination of the ion with biomolecules and predicted better free energies for proteins and nucleic acids. Here, we expand and refine the multisite model to describe the behavior of divalent ions in concentrated MgCl2 and CaCl2 electrolyte solutions, eliminating the unusual ion-ion pairing and clustering of ions which occurred in the original model. We calibrate and improve the parameters of the multisite model by matching the osmotic pressure of concentrated solutions of MgCl2 to the experimental values and then use these parameters to test the behavior of CaCl2 solutions. We find that the concentrated solutions of both divalent ions exhibit the experimentally observed behavior with correct osmotic pressure, the presence of solvent separated ion pairs instead of direct ion pairs, and no aggregation of ions. The improved multisite model for (Mg(2+) and Ca(2+)) can be used in classical simulations of biomolecules at physiologically relevant salt concentrations.

  8. Spectroscopic Observations of the Planets.

    DTIC Science & Technology

    2007-11-02

    1997). "The Surfaces of Pluto and Charon" D. P. Cruikshank, T. L. Roush, J. M. Moore, M. V. Sykes, T. Owen, M. J. Bartholomew, R. H. Brown, K. A...Tryka. In Pluto and Charon, ed. D. J. Tholen and S. A. Stern (Tucson, Univ. of Arizona Press) p. 221-268 (1997) . "From Planetesimals to Planets

  9. Hard X-ray Spectroscopic, Microwave and H-alpha Linear Polarization Studies with Hard X-Ray Observations from HESSI

    NASA Technical Reports Server (NTRS)

    Kiplinger, Alan L.

    2005-01-01

    The Principal Investigator (P.I.) has been pursuing a three year grant under NASA's Sun-Earth Connection Guest Investigator Program in support of the Ramaty High Energy Solar Spectroscopic Imager (RHESSI). An objective of these efforts is to combine X-ray and other data on solar flares, coronal mass ejections and interplanetary particle events in order to obtain a more comprehensive recognition of signatures, and understanding of interplanetary proton events. Thus, part of these efforts are to investigate if signatures seen in hard X-rays and microwaves can lead to better predictions of interplanetary proton events that can be dangerous to astronauts and spacecraft. The original proposal was written in May, 2000 and it discusses a three-pronged approach for data comparisons with three new types of instrumentation observing at X-ray, microwave and optical wavelengths. The major impetus behind this work and the proposal is that the P.I. discovered a strong correlation between a particular type of hard X-ray signature seen in spectral evolutions and interplanetary proton events (Kiplinger, 1995). The basic signature is that hard X-ray flux peaks either exhibit spectra that soften on their decays (Le. show fewer and fewer high energy X-rays with time) or they harden during decays (i.e. high energy X-rays decay significantly slower that lower energy X-rays). This signature is called progressive hardening. Studies were conducted over an eight-year period of data from the Hard X-Ray Burst Spectrometer (HXRBS) of the Solar maximum mission. Out of the 750 well observed flares studied, 41 flares had major associated proton events. Of these, 29 events were predicted on the basis of progressive hardening for a hit rate of 71%. The 152 largest flares had a hit rate of 82%.

  10. Candidate Water Vapor Lines to Locate the H2O Snowline through High-dispersion Spectroscopic Observations. I. The Case of a T Tauri Star

    NASA Astrophysics Data System (ADS)

    Notsu, Shota; Nomura, Hideko; Ishimoto, Daiki; Walsh, Catherine; Honda, Mitsuhiko; Hirota, Tomoya; Millar, T. J.

    2016-08-01

    Inside the H2O snowline of protoplanetary disks, water evaporates from the dust-grain surface into the gas phase, whereas it is frozen out onto the dust in the cold region beyond the snowline. H2O ice enhances the solid material in the cold outer part of a disk, which promotes the formation of gas-giant planet cores. We can regard the H2O snowline as the surface that divides the regions between rocky and gaseous giant planet formation. Thus observationally measuring the location of the H2O snowline is crucial for understanding the planetesimal and planet formation processes, and the origin of water on Earth. In this paper, we find candidate water lines to locate the H2O snowline through future high-dispersion spectroscopic observations. First, we calculate the chemical composition of the disk and investigate the abundance distributions of H2O gas and ice, and the position of the H2O snowline. We confirm that the abundance of H2O gas is high not only in the hot midplane region inside the H2O snowline but also in the hot surface layer of the outer disk. Second, we calculate the H2O line profiles and identify those H2O lines that are promising for locating the H2O snowline: the identified lines are those that have small Einstein A coefficients and high upper state energies. The wavelengths of the candidate H2O lines range from mid-infrared to sub-millimeter, and they overlap with the regions accessible to the Atacama Large Millimeter/sub-millimeter Array and future mid-infrared high-dispersion spectrographs (e.g., TMT/MICHI, SPICA).

  11. Spectroscopic Classifications of Optical Transients with SOAR

    NASA Astrophysics Data System (ADS)

    Foley, R. J.; Hounsell, R. A.; Downing, S.; Pan, Y.-C.; Scolnic, D.; Jha, S. W.; Rest, A.; Smith, K. W.; Wright, D.; Smartt, S. J.; Huber, M.; Chambers, K. C.; Flewelling, H.; Willman, M.; Primak, N.; Schultz, A.; Gibson, B.; Magnier, E.; Waters, C.; Tonry, J.; Wainscoat, R. J.

    2015-07-01

    We report the following classifications of optical transients from spectroscopic observations with the Goodman spectrograph (wavelength range 3100 - 7100) on the Southern Astrophysical Research (SOAR) telescope.

  12. Spectroscopic detection

    DOEpatents

    Woskov, Paul P.; Hadidi, Kamal

    2003-01-01

    In embodiments, spectroscopic monitor monitors modulated light signals to detect low levels of contaminants and other compounds in the presence of background interference. The monitor uses a spectrometer that includes a transmissive modulator capable of causing different frequency ranges to move onto and off of the detector. The different ranges can include those with the desired signal and those selected to subtract background contributions from those with the desired signal. Embodiments of the system are particularly useful for monitoring metal concentrations in combustion effluent.

  13. Multi-Sited Global Ethnography and Travel: Gendered Journeys in Three Registers

    ERIC Educational Resources Information Center

    Epstein, Debbie; Fahey, Johannah; Kenway, Jane

    2013-01-01

    This paper joins a barely begun conversation about multi-sited and global ethnography in educational research; a conversation that is likely to intensify along with growing interest in the links between education, globalisation, internationalisation and transnationalism. Drawing on an ongoing multi-sited global ethnography of elite schools and…

  14. Spectroscopic Observations of SN 2012fr: A Luminous, Normal Type Ia Supernova with Early High-velocity Features and a Late Velocity Plateau

    NASA Astrophysics Data System (ADS)

    Childress, M. J.; Scalzo, R. A.; Sim, S. A.; Tucker, B. E.; Yuan, F.; Schmidt, B. P.; Cenko, S. B.; Silverman, J. M.; Contreras, C.; Hsiao, E. Y.; Phillips, M.; Morrell, N.; Jha, S. W.; McCully, C.; Filippenko, A. V.; Anderson, J. P.; Benetti, S.; Bufano, F.; de Jaeger, T.; Forster, F.; Gal-Yam, A.; Le Guillou, L.; Maguire, K.; Maund, J.; Mazzali, P. A.; Pignata, G.; Smartt, S.; Spyromilio, J.; Sullivan, M.; Taddia, F.; Valenti, S.; Bayliss, D. D. R.; Bessell, M.; Blanc, G. A.; Carson, D. J.; Clubb, K. I.; de Burgh-Day, C.; Desjardins, T. D.; Fang, J. J.; Fox, O. D.; Gates, E. L.; Ho, I.-T.; Keller, S.; Kelly, P. L.; Lidman, C.; Loaring, N. S.; Mould, J. R.; Owers, M.; Ozbilgen, S.; Pei, L.; Pickering, T.; Pracy, M. B.; Rich, J. A.; Schaefer, B. E.; Scott, N.; Stritzinger, M.; Vogt, F. P. A.; Zhou, G.

    2013-06-01

    We present 65 optical spectra of the Type Ia SN 2012fr, 33 of which were obtained before maximum light. At early times, SN 2012fr shows clear evidence of a high-velocity feature (HVF) in the Si II λ6355 line that can be cleanly decoupled from the lower velocity "photospheric" component. This Si II λ6355 HVF fades by phase -5 subsequently, the photospheric component exhibits a very narrow velocity width and remains at a nearly constant velocity of ~12,000 km s-1 until at least five weeks after maximum brightness. The Ca II infrared triplet exhibits similar evidence for both a photospheric component at v ≈ 12,000 km s-1 with narrow line width and long velocity plateau, as well as an HVF beginning at v ≈ 31,000 km s-1 two weeks before maximum. SN 2012fr resides on the border between the "shallow silicon" and "core-normal" subclasses in the Branch et al. classification scheme, and on the border between normal and high-velocity Type Ia supernovae (SNe Ia) in the Wang et al. system. Though it is a clear member of the "low velocity gradient" group of SNe Ia and exhibits a very slow light-curve decline, it shows key dissimilarities with the overluminous SN 1991T or SN 1999aa subclasses of SNe Ia. SN 2012fr represents a well-observed SN Ia at the luminous end of the normal SN Ia distribution and a key transitional event between nominal spectroscopic subclasses of SNe Ia.

  15. Efficient multi-site two-photon functional imaging of neuronal circuits

    PubMed Central

    Castanares, Michael Lawrence; Gautam, Vini; Drury, Jack; Bachor, Hans; Daria, Vincent R.

    2016-01-01

    Two-photon imaging using high-speed multi-channel detectors is a promising approach for optical recording of cellular membrane dynamics at multiple sites. A main bottleneck of this technique is the limited number of photons captured within a short exposure time (~1ms). Here, we implement temporal gating to improve the two-photon fluorescence yield from holographically projected multiple foci whilst maintaining a biologically safe incident average power. We observed up to 6x improvement in the signal-to-noise ratio (SNR) in Fluorescein and cultured hippocampal neurons showing evoked calcium transients. With improved SNR, we could pave the way to achieving multi-site optical recording of fluorogenic probes with response times in the order of ~1ms. PMID:28018745

  16. Spectroscopic Binary Stars

    NASA Astrophysics Data System (ADS)

    Batten, A.; Murdin, P.

    2000-11-01

    Historically, spectroscopic binary stars were binary systems whose nature was discovered by the changing DOPPLER EFFECT or shift of the spectral lines of one or both of the component stars. The observed Doppler shift is a combination of that produced by the constant RADIAL VELOCITY (i.e. line-of-sight velocity) of the center of mass of the whole system, and the variable shift resulting from the o...

  17. Control of spatially patterned synchrony with multisite delayed feedback

    NASA Astrophysics Data System (ADS)

    Hauptmann, C.; Omel‘Chenko, O.; Popovych, O. V.; Maistrenko, Y.; Tass, P. A.

    2007-12-01

    We present an analytical study describing a method for the control of spatiotemporal patterns of synchrony in networks of coupled oscillators. Delayed feedback applied through a small number of electrodes effectively induces spatiotemporal dynamics at minimal stimulation intensities. Different arrangements of the delays cause different spatial patterns of synchrony, comparable to central pattern generators (CPGs), i.e., interacting clusters of oscillatory neurons producing patterned output, e.g., for motor control. Multisite delayed feedback stimulation might be used to restore CPG activity in patients with incomplete spinal cord injury or gait ignition disorders.

  18. High-resolution Spectroscopic Observations of Binary Stars and Yellow Stragglers in Three Open Clusters : NGC 2360, NGC 3680, and NGC 5822

    NASA Astrophysics Data System (ADS)

    Sales Silva, J. V.; Peña Suárez, V. J.; Katime Santrich, O. J.; Pereira, C. B.; Drake, N. A.; Roig, F.

    2014-11-01

    Binary stars in open clusters are very useful targets in constraining the nucleosynthesis process. The luminosities of the stars are known because the distances of the clusters are also known, so chemical peculiarities can be linked directly to the evolutionary status of a star. In addition, binary stars offer the opportunity to verify a relationship between them and the straggler population in both globular and open clusters. We carried out a detailed spectroscopic analysis to derive the atmospheric parameters for 16 red giants in binary systems and the chemical composition of 11 of them in the open clusters NGC 2360, NGC 3680, and NGC 5822. We obtained abundances of C, N, O, Na, Mg, Al, Ca, Si, Ti, Ni, Cr, Y, Zr, La, Ce, and Nd. The atmospheric parameters of the studied stars and their chemical abundances were determined using high-resolution optical spectroscopy. We employ the local thermodynamic equilibrium model atmospheres of Kurucz and the spectral analysis code MOOG. The abundances of the light elements were derived using the spectral synthesis technique. We found that the stars NGC 2360-92 and 96, NGC 3680-34, and NGC 5822-4 and 312 are yellow straggler stars. We show that the spectra of NGC 5822-4 and 312 present evidence of contamination by an A-type star as a secondary star. For the other yellow stragglers, evidence of contamination is given by the broad wings of the Hα. Detection of yellow straggler stars is important because the observed number can be compared with the number predicted by simulations of binary stellar evolution in open clusters. We also found that the other binary stars are not s-process enriched, which may suggest that in these binaries the secondary star is probably a faint main-sequence object. The lack of any s-process enrichment is very useful in setting constraints for the number of white dwarfs in the open cluster, a subject that is related to the birthrate of these kinds of stars in open clusters and also to the age of a

  19. The s-process in low-metallicity stars - II. Interpretation of high-resolution spectroscopic observations with asymptotic giant branch models

    NASA Astrophysics Data System (ADS)

    Bisterzo, S.; Gallino, R.; Straniero, O.; Cristallo, S.; Käppeler, F.

    2011-11-01

    High-resolution spectroscopic observations of 100 metal-poor carbon and s-rich stars (CEMP-s) collected from the literature are compared with the theoretical nucleosynthesis models of the asymptotic giant branch (AGB) presented in Paper I (MAGBini= 1.3, 1.4, 1.5, 2 M⊙, - 3.6 ≲ [ Fe/H ] ≲- 1.5). The s-process enhancement detected in these objects is associated with binary systems: the more massive companion evolved faster through the thermally pulsing AGB phase (TP-AGB), synthesizing s-elements in the inner He intershell, which are partly dredged up to the surface during the third dredge-up (TDU) episode. The secondary observed low-mass companion became CEMP-s by the mass transfer of C- and s-rich material from the primary AGB. We analyse the light elements C, N, O, Na and Mg, as well as the two s-process indicators, [hs/ls] (where ls = is the the light-s peak at N = 50 and hs = the heavy-s peak at N = 82) and [Pb/hs]. We distinguish between CEMP-s with high s-process enhancement, [hs/Fe] >rsim 1.5 (CEMP-sII), and mild s-process enhanced stars, [hs/Fe] < 1.5 (CEMP-sI). To interpret the observations, a range of s-process efficiencies at any given metallicity is necessary. This is confirmed by the high spread observed in [Pb/hs] (˜2 dex). A degeneration of solutions is found with some exceptions: most main-sequence CEMP-sII stars with low [Na/Fe] can only be interpreted with MAGBini= 1.3-1.4 M⊙. Giants having suffered the first dredge-up (FDU) need a dilution >rsim1 dex (dil is defined as the mass of the convective envelope of the observed star, Mobs★, over the material transferred from the AGB to the companion, MtransAGB). Then AGB models with higher AGB initial masses (MAGBini= 1.5-2 M⊙) are adopted to interpret CEMP-sII giants. In general, solutions with AGB models in the mass range MAGBini= 1.3-2 M⊙ and different dilution factors are found for CEMP-sI stars. About half of the CEMP-s stars with europium measurements show a high r

  20. Multisite multivariate modeling of daily precipitation and temperature in the Canadian Prairie Provinces using generalized linear models

    NASA Astrophysics Data System (ADS)

    Asong, Zilefac E.; Khaliq, M. N.; Wheater, H. S.

    2016-11-01

    Based on the Generalized Linear Model (GLM) framework, a multisite stochastic modelling approach is developed using daily observations of precipitation and minimum and maximum temperatures from 120 sites located across the Canadian Prairie Provinces: Alberta, Saskatchewan and Manitoba. Temperature is modeled using a two-stage normal-heteroscedastic model by fitting mean and variance components separately. Likewise, precipitation occurrence and conditional precipitation intensity processes are modeled separately. The relationship between precipitation and temperature is accounted for by using transformations of precipitation as covariates to predict temperature fields. Large scale atmospheric covariates from the National Center for Environmental Prediction Reanalysis-I, teleconnection indices, geographical site attributes, and observed precipitation and temperature records are used to calibrate these models for the 1971-2000 period. Validation of the developed models is performed on both pre- and post-calibration period data. Results of the study indicate that the developed models are able to capture spatiotemporal characteristics of observed precipitation and temperature fields, such as inter-site and inter-variable correlation structure, and systematic regional variations present in observed sequences. A number of simulated weather statistics ranging from seasonal means to characteristics of temperature and precipitation extremes and some of the commonly used climate indices are also found to be in close agreement with those derived from observed data. This GLM-based modelling approach will be developed further for multisite statistical downscaling of Global Climate Model outputs to explore climate variability and change in this region of Canada.

  1. High-resolution spectroscopic observations of binary stars and yellow stragglers in three open clusters: NGC 2360, NGC 3680, and NGC 5822

    SciTech Connect

    Sales Silva, J. V.; Peña Suárez, V. J.; Katime Santrich, O. J.; Pereira, C. B.; Drake, N. A.; Roig, F. E-mail: jearim@on.br E-mail: claudio@on.br E-mail: froig@on.br

    2014-11-01

    Binary stars in open clusters are very useful targets in constraining the nucleosynthesis process. The luminosities of the stars are known because the distances of the clusters are also known, so chemical peculiarities can be linked directly to the evolutionary status of a star. In addition, binary stars offer the opportunity to verify a relationship between them and the straggler population in both globular and open clusters. We carried out a detailed spectroscopic analysis to derive the atmospheric parameters for 16 red giants in binary systems and the chemical composition of 11 of them in the open clusters NGC 2360, NGC 3680, and NGC 5822. We obtained abundances of C, N, O, Na, Mg, Al, Ca, Si, Ti, Ni, Cr, Y, Zr, La, Ce, and Nd. The atmospheric parameters of the studied stars and their chemical abundances were determined using high-resolution optical spectroscopy. We employ the local thermodynamic equilibrium model atmospheres of Kurucz and the spectral analysis code MOOG. The abundances of the light elements were derived using the spectral synthesis technique. We found that the stars NGC 2360-92 and 96, NGC 3680-34, and NGC 5822-4 and 312 are yellow straggler stars. We show that the spectra of NGC 5822-4 and 312 present evidence of contamination by an A-type star as a secondary star. For the other yellow stragglers, evidence of contamination is given by the broad wings of the Hα. Detection of yellow straggler stars is important because the observed number can be compared with the number predicted by simulations of binary stellar evolution in open clusters. We also found that the other binary stars are not s-process enriched, which may suggest that in these binaries the secondary star is probably a faint main-sequence object. The lack of any s-process enrichment is very useful in setting constraints for the number of white dwarfs in the open cluster, a subject that is related to the birthrate of these kinds of stars in open clusters and also to the age of a

  2. In-Situ Measurements of HCN and CH3CN in the Pacific Troposphere: Sources, Sinks, and Comparisons with Spectroscopic Observations

    NASA Technical Reports Server (NTRS)

    Singh, Hanwant B.; Salas, L.; Herlth, D.; Czech, E.; Viezee, W.; Li, Q.; Jacob, D. J.; Blake, D.; Sachse, G.; Harward, C. N.; Hipskind, R. Stephen (Technical Monitor)

    2002-01-01

    We report the first in-situ measurements of hydrogen cyanide (HCN) and acetonitrile (CH3CN) from the Pacific troposphere (0-12 km) obtained during the NASA/Trace-P mission (Feb.-April, 2001). Mean HCN and CH3CN mixing ratios of 243 (+/-118) ppt and 149 (+/-56) ppt respectively, were measured. The in-situ observations correspond to a total HCN column of 4.4-4.9 x 10(exp 15) molec. cm(exp -2) and a CH3CN column of 2.8-3.0 x 10(exp 15) molec. cm(exp -2). This HCN column is in good agreement with available spectroscopic observations. The atmospheric concentrations of HCN and CH3CN were greatly influenced by outflow of pollution from Asia. There is a linear relationship between the mixing ratios of HCN and CH3CN, and in turn these are well correlated with tracers of biomass combustion (e.g. CH3Cl, CO). Relative enhancements with respect to known tracers of biomass combustion within selected plumes in the free troposphere, and pollution episodes in the boundary layer allow an estimation of a global biomass burning source of 0.8+/-0.4 Tg (N)/y for HCN and 0.4+/-0.1 Tg (N)/y for CH3CN. In comparison, emissions from automobiles and industry are quite small (<0.05 Tg (N)/y). The vertical structure of HCN and CH3CN indicated reduced mixing ratios in the MBL (Marine Boundary Layer). Using, a simple box model, the observed gradients across the top of the MBL are used to derive an oceanic flux of 6.7 x 10(exp -15) g (N) cm(exp -2)/s for HCN and 4.8 x 10(exp -15) g (N) cm(exp -2)/s for CH3CN. An air-sea exchange model is used to conclude that this flux can be maintained if the oceans are under-saturated in HCN and CH3CN by 23% and 17%, respectively. It is inferred that oceanic loss is a dominant sink for these nitrites, and they deposit some 1.3 Tg (N) of nitrogen annually to the oceans. Assuming reaction with OH radicals and loss to the oceans as the major removal processes, a mean atmospheric residence time of 4.7 months for HCN and 5.1 months for CH3CN is calculated. A global

  3. Spectroscopic pulsational frequency identification and mode determination of γ Doradus star HD 12901

    NASA Astrophysics Data System (ADS)

    Brunsden, E.; Pollard, K. R.; Cottrell, P. L.; Wright, D. J.; De Cat, P.

    2012-12-01

    Using multisite spectroscopic data collected from three sites, the frequencies and pulsational modes of the γ Doradus star HD 12901 were identified. A total of six frequencies in the range 1-2 d-1 were observed, their identifications supported by multiple line-profile measurement techniques and previously published photometry. Five frequencies were of sufficient signal-to-noise ratio for mode identification, and all five displayed similar three-bump standard deviation profiles which were fitted well with (l,m) = (1,1) modes. These fits had reduced χ2 values of less than 18. We propose that this star is an excellent candidate to test models of non-radially pulsating γ Doradus stars as a result of the presence of multiple (1,1) modes. This paper includes data taken at the Mount John University Observatory of the University of Canterbury (New Zealand), the McDonald Observatory of the University of Texas at Austin (Texas, USA) and the European Southern Observatory at La Silla (Chile).

  4. Multisite reliability of MR-based functional connectivity.

    PubMed

    Noble, Stephanie; Scheinost, Dustin; Finn, Emily S; Shen, Xilin; Papademetris, Xenophon; McEwen, Sarah C; Bearden, Carrie E; Addington, Jean; Goodyear, Bradley; Cadenhead, Kristin S; Mirzakhanian, Heline; Cornblatt, Barbara A; Olvet, Doreen M; Mathalon, Daniel H; McGlashan, Thomas H; Perkins, Diana O; Belger, Aysenil; Seidman, Larry J; Thermenos, Heidi; Tsuang, Ming T; van Erp, Theo G M; Walker, Elaine F; Hamann, Stephan; Woods, Scott W; Cannon, Tyrone D; Constable, R Todd

    2017-02-01

    Recent years have witnessed an increasing number of multisite MRI functional connectivity (fcMRI) studies. While multisite studies provide an efficient way to accelerate data collection and increase sample sizes, especially for rare clinical populations, any effects of site or MRI scanner could ultimately limit power and weaken results. Little data exists on the stability of functional connectivity measurements across sites and sessions. In this study, we assess the influence of site and session on resting state functional connectivity measurements in a healthy cohort of traveling subjects (8 subjects scanned twice at each of 8 sites) scanned as part of the North American Prodrome Longitudinal Study (NAPLS). Reliability was investigated in three types of connectivity analyses: (1) seed-based connectivity with posterior cingulate cortex (PCC), right motor cortex (RMC), and left thalamus (LT) as seeds; (2) the intrinsic connectivity distribution (ICD), a voxel-wise connectivity measure; and (3) matrix connectivity, a whole-brain, atlas-based approach to assessing connectivity between nodes. Contributions to variability in connectivity due to subject, site, and day-of-scan were quantified and used to assess between-session (test-retest) reliability in accordance with Generalizability Theory. Overall, no major site, scanner manufacturer, or day-of-scan effects were found for the univariate connectivity analyses; instead, subject effects dominated relative to the other measured factors. However, summaries of voxel-wise connectivity were found to be sensitive to site and scanner manufacturer effects. For all connectivity measures, although subject variance was three times the site variance, the residual represented 60-80% of the variance, indicating that connectivity differed greatly from scan to scan independent of any of the measured factors (i.e., subject, site, and day-of-scan). Thus, for a single 5min scan, reliability across connectivity measures was poor (ICC=0

  5. Multi-site identification of a distributed hydrological nitrogen model using Bayesian uncertainty analysis

    NASA Astrophysics Data System (ADS)

    Jiang, Sanyuan; Jomaa, Seifeddine; Büttner, Olaf; Meon, Günter; Rode, Michael

    2015-10-01

    For capturing spatial variations of runoff and nutrient fluxes attributed to catchment heterogeneity, multi-site hydrological water quality monitoring strategies are increasingly put into practice. This study aimed to investigate the impacts of spatially distributed streamflow and streamwater Inorganic Nitrogen (IN) concentration observations on the identification of a continuous time, spatially semi-distributed and process-based hydrological water quality model HYPE (HYdrological Predictions for the Environment). A Bayesian inference based approach DREAM(ZS) (DiffeRential Evolution Adaptive Metrololis algorithm) was combined with HYPE to implement model optimisation and uncertainty analysis on streamflow and streamwater IN concentration simulations at a nested meso scale catchment in central Germany. To this end, a 10-year period (1994-1999 for calibration and 1999-2004 for validation) was utilised. We compared the parameters' posterior distributions, modelling performance using the best estimated parameter set and 95% prediction confidence intervals at catchment outlet for the calibration period that were derived from single-site calibration (SSC) and multi-site calibration (MSC) modes. For SSC, streamflow and streamwater IN concentration observations at only the catchment outlet were used. While, for MSC, streamflow and streamwater IN concentration observations from both catchment outlet and two internal sites were considered. Results showed that the uncertainty intervals of hydrological water quality parameters' posterior distributions estimated from MSC, were narrower than those obtained from SSC. In addition, it was found that the MSC outperformed SSC on streamwater IN concentration simulations at internal sites for both calibration and validation periods, while the influence on streamflow modelling performance was small. This can be explained by the "nested" nature of the catchment and high correlation between discharge observations from different sites

  6. Studying multisite binary and ternary protein interactions by global analysis of isothermal titration calorimetry data in SEDPHAT: application to adaptor protein complexes in cell signaling.

    PubMed

    Houtman, Jon C D; Brown, Patrick H; Bowden, Brent; Yamaguchi, Hiroshi; Appella, Ettore; Samelson, Lawrence E; Schuck, Peter

    2007-01-01

    Multisite interactions and the formation of ternary or higher-order protein complexes are ubiquitous features of protein interactions. Cooperativity between different ligands is a hallmark for information transfer, and is frequently critical for the biological function. We describe a new computational platform for the global analysis of isothermal titration calorimetry (ITC) data for the study of binary and ternary multisite interactions, implemented as part of the public domain multimethod analysis software SEDPHAT. The global analysis of titrations performed in different orientations was explored, and the potential for unraveling cooperativity parameters in multisite interactions was assessed in theory and experiment. To demonstrate the practical potential and limitations of global analyses of ITC titrations for the study of cooperative multiprotein interactions, we have examined the interactions of three proteins that are critical for signal transduction after T-cell activation, LAT, Grb2, and Sos1. We have shown previously that multivalent interactions between these three molecules promote the assembly of large multiprotein complexes important for T-cell receptor activation. By global analysis of the heats of binding observed in sets of ITC injections in different orientations, which allowed us to follow the formation of binary and ternary complexes, we observed negative and positive cooperativity that may be important to control the pathway of assembly and disassembly of adaptor protein particles.

  7. Statistical multi-site fatigue damage analysis model

    NASA Astrophysics Data System (ADS)

    Wang, G. S.

    1995-02-01

    A statistical model has been developed to evaluate fatigue damage at multi-sites in complex joints based on coupon test data and fracture mechanics methods. The model is similar to the USAF model, but modified by introducing a failure criterion and a probability of fatal crack occurrence to account for the multiple site damage phenomenon. The involvement of NDI techniques has been included in the model which can be used to evaluate the structural reliability, the detectability of fatigue damage (cracks), and the risk of failure based on NDI results taken from samples. A practical example is provided for rivet fasteners and bolted fasteners. It is shown that the model can be used even if it is based on conventional S-N coupon experiments should further fractographic inspections be made for cracks on the broken surfaces of specimens.

  8. Asiago spectroscopic classification of SN2017mf

    NASA Astrophysics Data System (ADS)

    Ochner, P.; Benetti, S.; Tomasella, L.; Cappellaro, E.; Elias-Rosa, N.; Pastorello, P.; Turatto, M.; Terreran, G

    2017-01-01

    The Asiago Transient Classification Program (Tomasella et al. 2014, AN, 335, 841) reports the spectroscopic observation of SN2017mf. The observation was performed with the Asiago 1.22-m Galileo Telescope (+ Boller & Chivens spectrograph).

  9. The relationship between involvement in and use of evaluation in multi-site evaluations.

    PubMed

    Roseland, Denise; Lawrenz, Frances; Thao, Mao

    2015-02-01

    This research explores the relationship between participation in evaluation and the use of evaluation findings and processes within three large-scale multi-site evaluations. Using canonical correlation analysis and a collection of 20 interviews, this study describes and tests the relationship between these two critical conceptual powerhouses in evaluation. Using data that were collected as a part of the NSF-funded research Beyond Evaluation Use (Lawrenz & King, 2009), this study found that some theories and beliefs about participatory evaluation contribute to use and influence in similar ways as in single-site evaluations. The differences identified in this research highlight potential planning and implementation considerations that might allow multi-site evaluators and funders of multi-site evaluation to enhance use and influence of multi-site evaluations.

  10. Efficient Calculations with Multisite Local Orbitals in a Large-Scale DFT Code CONQUEST.

    PubMed

    Nakata, Ayako; Bowler, David R; Miyazaki, Tsuyoshi

    2014-11-11

    Multisite local orbitals, which are formed from linear combinations of pseudoatomic orbitals from a target atom and its neighbor atoms, have been introduced in the large-scale density functional theory calculation code CONQUEST. Multisite local orbitals correspond to local molecular orbitals so that the number of required local orbitals can be minimal. The multisite support functions are determined by using the localized filter diagonalization (LFD) method [ Phys. Rev. B 2009 , 80 , 205104 ]. Two new methods, the double cutoff method and the smoothing method, are introduced to the LFD method to improve efficiency and stability. The Hamiltonian and overlap matrices with multisite local orbitals are constructed by efficient sparse-matrix multiplications in CONQUEST. The investigation of the calculated energetic and geometrical properties and band structures of bulk Si, Al, and DNA systems demonstrate the accuracy and the computational efficiency of the present method. The representability of both occupied and unoccupied band structures with the present method has been also confirmed.

  11. Ultrasensitivity and sharp threshold theorems for multisite systems

    NASA Astrophysics Data System (ADS)

    Dougoud, M.; Mazza, C.; Vinckenbosch, L.

    2017-02-01

    This work studies the ultrasensitivity of multisite binding processes where ligand molecules can bind to several binding sites. It considers more particularly recent models involving complex chemical reactions in allosteric phosphorylation processes and for transcription factors and nucleosomes competing for binding on DNA. New statistics-based formulas for the Hill coefficient and the effective Hill coefficient are provided and necessary conditions for a system to be ultrasensitive are exhibited. It is first shown that the ultrasensitivity of binding processes can be approached using sharp-threshold theorems which have been developed in applied probability theory and statistical mechanics for studying sharp threshold phenomena in reliability theory, random graph theory and percolation theory. Special classes of binding process are then introduced and are described as density dependent birth and death process. New precise large deviation results for the steady state distribution of the process are obtained, which permits to show that switch-like ultrasensitive responses are strongly related to the multi-modality of the steady state distribution. Ultrasensitivity occurs if and only if the entropy of the dynamical system has more than one global minimum for some critical ligand concentration. In this case, the Hill coefficient is proportional to the number of binding sites, and the system is highly ultrasensitive. The classical effective Hill coefficient I is extended to a new cooperativity index I q , for which we recommend the computation of a broad range of values of q instead of just the standard one I  =  I 0.9 corresponding to the 10%-90% variation in the dose-response. It is shown that this single choice can sometimes mislead the conclusion by not detecting ultrasensitivity. This new approach allows a better understanding of multisite ultrasensitive systems and provides new tools for the design of such systems.

  12. PS2-06: Best Practices for Advancing Multi-site Chart Abstraction Research

    PubMed Central

    Blick, Noelle; Cole, Deanna; King, Colleen; Riordan, Rick; Von Worley, Ann; Yarbro, Patty

    2012-01-01

    Background/Aims Multi-site chart abstraction studies are becoming increasingly common within the HMORN. Differences in systems among HMORN sites can pose significant obstacles to the success of these studies. It is therefore crucial to standardize abstraction activities by following best practices for multi-site chart abstraction, as consistency of processes across sites will increase efficiencies and enhance data quality. Methods Over the past few months the authors have been meeting to identify obstacles to multi-site chart abstraction and to address ways in which multi-site chart abstraction processes can be systemized and standardized. The aim of this workgroup is to create a best practice guide for multi-site chart abstraction studies. Focus areas include: abstractor training, format for chart abstraction (database, paper, etc), data quality, redaction, mechanism for transferring data, site specific access to medical records, IRB/HIPAA concerns, and budgetary issues. Results The results of the workgroup’s efforts (the best practice guide) will be presented by a panel of experts at the 2012 HMORN conference. The presentation format will also focus on discussion among attendees to elicit further input and to identify areas that need to be further addressed. Subsequently, the best practice guide will be posted on the HMORN website. Discussion The best practice guide for multi-site chart abstraction studies will establish sound guidelines and serve as an aid to researchers embarking on multi-site chart abstraction studies. Efficiencies and data quality will be further enhanced with standardized multi-site chart abstraction practices.

  13. High-Accuracy Quartic Force Field Calculations for the Spectroscopic Constants and Vibrational Frequencies of 1(exp 1)A' l-C3H(-): A Possible Link to Lines Observed in the Horsehead Nebula PDR

    NASA Technical Reports Server (NTRS)

    Fortenberry, Ryan C.; Huang, Xinchuan; Crawford, T. Daniel; Lee, Timothy J.

    2013-01-01

    It has been shown that rotational lines observed in the Horsehead nebula photon-dominated-region (PDR) are probably not caused by l-C3H+, as was originally suggested. In the search for viable alternative candidate carriers, quartic force fields are employed here to provide highly accurate rotational constants, as well as fundamental vibrational frequencies, for another candidate carrier: 1 (sup 1)A' C3H(-). The ab initio computed spectroscopic constants provided in this work are, compared to those necessary to define the observed lines, as accurate as the computed spectroscopic constants for many of the known interstellar anions. Additionally, the computed D-eff for C3H(-) is three times closer to the D deduced from the observed Horsehead nebula lines relative to l-C3H(+). As a result, 1 (sup 1)A' C3H(-). is a more viable candidate for these observed rotational transitions and would be the seventh confirmed interstellar anion detected within the past decade and the first C(sub n)H(-) molecular anion with an odd n.

  14. Basal inflammation and innate immune response in chronic multisite musculoskeletal pain.

    PubMed

    Generaal, Ellen; Vogelzangs, Nicole; Macfarlane, Gary J; Geenen, Rinie; Smit, Johannes H; Dekker, Joost; Penninx, Brenda W J H

    2014-08-01

    Dysregulation of the immune system may play a role in chronic pain, although study findings are inconsistent. This cross-sectional study examined whether basal inflammatory markers and the innate immune response are associated with the presence and severity of chronic multisite musculoskeletal pain. Data were used on 1632 subjects of the Netherlands Study of Depression and Anxiety. The Chronic Pain Grade questionnaire was used to determine the presence and severity of chronic multisite musculoskeletal pain. Subjects were categorized in a chronic multisite musculoskeletal pain group (n=754) and a control group (n=878). Blood levels of the basal inflammatory markers C-reactive protein, interleukin-6, and tumor necrosis factor-alpha were determined. To obtain a measure of the innate immune response, 13 inflammatory markers were assessed after lipopolysaccharide (LPS) stimulation in a subsample (n=707). Subjects with chronic multisite musculoskeletal pain showed elevated levels of basal inflammatory markers compared with controls, but statistical significance was lost after adjustment for lifestyle and disease variables. For some LPS-stimulated inflammatory markers, we did find elevated levels in subjects with chronic multisite musculoskeletal pain both before and after adjustment for covariates. Pain severity was not associated with inflammation within chronic pain subjects. An enhanced innate immune response in chronic multisite musculoskeletal pain may be examined as a potential biomarker for the onset or perpetuation of chronic pain.

  15. Increasing the ranks of academic researchers in mental health: a multisite approach to postdoctoral fellowship training.

    PubMed

    O'Hara, Ruth; Cassidy-Eagle, Erin L; Beaudreau, Sherry A; Eyler, Lisa T; Gray, Heather L; Giese-Davis, Janine; Hubbard, Jeffrey; Yesavage, Jerome A

    2010-01-01

    This report highlights the use of multisite training for psychiatry and psychology postdoctoral fellows developing careers in academic clinical research in the field of mental health. The objective is to describe a model of training for young investigators to establish independent academic clinical research careers, including (1) program structure and eligibility, (2) program goals and development of a multisite curriculum, (3) use of technology for implementing the program across multiple sites, and (4) advantages and challenges of this multisite approach. In 2000, in collaboration with the Veterans Affairs (VA) Mental Illness Research, Education and Clinical Centers (MIRECCs), the VA Office of Academic Affiliations launched the Special Fellowship Program in Advanced Psychiatry and Psychology. Each of the 10 currently participating VA sites across the United States is affiliated with a MIRECC and an academic medical institution. In the first five years of this fellowship program, 83 fellows (34 psychiatrists and 49 psychologists) have participated. The success of this multisite approach is evidenced by the 58 fellows who have already graduated from the program: 70% have entered academic clinical research positions, and over 25 have obtained independent extramural grant support from the VA or the National Institutes of Health. Multisite training results in a greater transfer of knowledge and capitalizes on the nationwide availability of experts, creating unique networking and learning opportunities for trainees. The VA's multisite fellowship program plays a valuable role in preparing substantial numbers of psychiatry and psychology trainees for a range of academic clinical research and leadership positions in the field of mental health.

  16. The value and potential of multisited ethnography for science education research: a review of Jrène Rahm's Science in the Making at the Margin

    NASA Astrophysics Data System (ADS)

    Beeman-Cadwallader, Nicole

    2012-03-01

    Rahm sought to illuminate how children and youth make meaning of science in three out-of-school time programs, and the identity work that is done through the trajectory of their youth toward their young adulthood. Through using multisited ethnography, she asserts that we can learn more about what the youth say about their science learning and science literacy development in these programs. She has revealed through her rich data the potential value of multisited ethnography for science education research. A similar theme of insider/outsider status to science emerged in each of the three sites. The nature of the data collected in Rahm's multisited ethnography allowed for the unveiling of the similarities in this theme, but also made evident the nuanced ways that this theme presented itself differently across the three sites. The additional potential came through in the varied data Rahm could have delved into and did not. A unique characteristic of ethnographic research, that is not necessarily present in other research methods, is that a wide array of varied data is collected. An analysis of documents, images, and observational field notes, which go beyond interview data, may provide deeper understandings previously untouched in science education.

  17. A DVD Spectroscope: A Simple, High-Resolution Classroom Spectroscope

    ERIC Educational Resources Information Center

    Wakabayashi, Fumitaka; Hamada, Kiyohito

    2006-01-01

    Digital versatile disks (DVDs) have successfully made up an inexpensive but high-resolution spectroscope suitable for classroom experiments that can easily be made with common material and gives clear and fine spectra of various light sources and colored material. The observed spectra can be photographed with a digital camera, and such images can…

  18. THE HYPERFINE STRUCTURE OF THE ROTATIONAL SPECTRUM OF HDO AND ITS EXTENSION TO THE THz REGION: ACCURATE REST FREQUENCIES AND SPECTROSCOPIC PARAMETERS FOR ASTROPHYSICAL OBSERVATIONS

    SciTech Connect

    Cazzoli, Gabriele; Lattanzi, Valerio; Puzzarini, Cristina; Alonso, José Luis; Gauss, Jürgen

    2015-06-10

    The rotational spectrum of the mono-deuterated isotopologue of water, HD{sup 16}O, has been investigated in the millimeter- and submillimeter-wave frequency regions, up to 1.6 THz. The Lamb-dip technique has been exploited to obtain sub-Doppler resolution and to resolve the hyperfine (hf) structure due to the deuterium and hydrogen nuclei, thus enabling the accurate determination of the corresponding hf parameters. Their experimental determination has been supported by high-level quantum-chemical calculations. The Lamb-dip measurements have been supplemented by Doppler-limited measurements (weak high-J and high-frequency transitions) in order to extend the predictive capability of the available spectroscopic constants. The possibility of resolving hf splittings in astronomical spectra has been discussed.

  19. Multisite Phosphorylation Provides an Effective and Flexible Mechanism for Switch-Like Protein Degradation

    PubMed Central

    Varedi K., S. Marjan; Ventura, Alejandra C.; Merajver, Sofia D.; Lin, Xiaoxia Nina

    2010-01-01

    Phosphorylation-triggered degradation is a common strategy for elimination of regulatory proteins in many important cell signaling processes. Interesting examples include cyclin-dependent kinase inhibitors such as p27 in human and Sic1 in yeast, which play crucial roles during the G1/S transition in the cell cycle. In this work, we have modeled and analyzed the dynamics of multisite-phosphorylation-triggered protein degradation systematically. Inspired by experimental observations on the Sic1 protein and a previous intriguing theoretical conjecture, we develop a model to examine in detail the degradation dynamics of a protein featuring multiple phosphorylation sites and a threshold site number for elimination in response to a kinase signal. Our model explains the role of multiple phosphorylation sites, compared to a single site, in the regulation of protein degradation. A single-site protein cannot convert a graded input of kinase increase to much sharper output, whereas multisite phosphorylation is capable of generating a highly switch-like temporal profile of the substrate protein with two characteristics: a temporal threshold and rapid decrease beyond the threshold. We introduce a measure termed temporal response coefficient to quantify the extent to which a response in the time domain is switch-like and further investigate how this property is determined by various factors including the kinase input, the total number of sites, the threshold site number for elimination, the order of phosphorylation, the kinetic parameters, and site preference. Some interesting and experimentally verifiable predictions include that the non-degradable fraction of the substrate protein exhibits a more switch-like temporal profile; a sequential system is more switch-like, while a random system has the advantage of increased robustness; all the parameters, including the total number of sites, the threshold site number for elimination and the kinetic parameters synergistically

  20. Multisite phosphorylation provides an effective and flexible mechanism for switch-like protein degradation.

    PubMed

    Varedi K, S Marjan; Ventura, Alejandra C; Merajver, Sofia D; Lin, Xiaoxia Nina

    2010-12-13

    Phosphorylation-triggered degradation is a common strategy for elimination of regulatory proteins in many important cell signaling processes. Interesting examples include cyclin-dependent kinase inhibitors such as p27 in human and Sic1 in yeast, which play crucial roles during the G1/S transition in the cell cycle. In this work, we have modeled and analyzed the dynamics of multisite-phosphorylation-triggered protein degradation systematically. Inspired by experimental observations on the Sic1 protein and a previous intriguing theoretical conjecture, we develop a model to examine in detail the degradation dynamics of a protein featuring multiple phosphorylation sites and a threshold site number for elimination in response to a kinase signal. Our model explains the role of multiple phosphorylation sites, compared to a single site, in the regulation of protein degradation. A single-site protein cannot convert a graded input of kinase increase to much sharper output, whereas multisite phosphorylation is capable of generating a highly switch-like temporal profile of the substrate protein with two characteristics: a temporal threshold and rapid decrease beyond the threshold. We introduce a measure termed temporal response coefficient to quantify the extent to which a response in the time domain is switch-like and further investigate how this property is determined by various factors including the kinase input, the total number of sites, the threshold site number for elimination, the order of phosphorylation, the kinetic parameters, and site preference. Some interesting and experimentally verifiable predictions include that the non-degradable fraction of the substrate protein exhibits a more switch-like temporal profile; a sequential system is more switch-like, while a random system has the advantage of increased robustness; all the parameters, including the total number of sites, the threshold site number for elimination and the kinetic parameters synergistically

  1. Structural integrity of fuselage panels with multisite damage

    NASA Astrophysics Data System (ADS)

    Park, Jai H.; Singh, Ripudaman; Pyo, Chang R.; Atluris, Satya N.

    1995-05-01

    Structural integrity assessment of aging flight vehicles is extremely important to ensure their economic and safe operation. A two-step analytical approach, developed to estimate the residual strength of pressurized fuselage stiffened shell panels with multi-bay fatigue cracking is presented in this article. Conventional finite element analysis of the damaged multibay panel is first carried out to obtain the load flow pattern through it. The Schwartz-Neumann alternating method is then applied to the fuselage skin with multiple site damage, to obtain stresses and the relevant crack tip parameters that govern the onset of fracture. Fracture mechanics as well as net section yield criteria are used to evaluate the static residual strength. The presence of holes with or without multisite damage ahead of a dominant crack is found to significantly degrade the capacity of the fuselage shell panels to sustain static internal pressure. An elastic-plastic alternating method is newly developed and applied to evaluate the residual strength of flat panels with multiple cracks. The computational methodologies presented herein are marked improvements to the present state-of-the-art, and are extremely efficient, both from engineering manpower as well as computational costs point of view. Once verified, they can very well complement the experimental requirements, reducing the cost of structural integrity assessment programs.

  2. Multisite clickable modification of proteins using lipoic acid ligase.

    PubMed

    Plaks, Joseph G; Falatach, Rebecca; Kastantin, Mark; Berberich, Jason A; Kaar, Joel L

    2015-06-17

    Approaches that allow bioorthogonal and, in turn, site-specific chemical modification of proteins present considerable opportunities for modulating protein activity and stability. However, the development of such approaches that enable site-selective modification of proteins at multiple positions, including internal sites within a protein, has remained elusive. To overcome this void, we have developed an enzymatic approach for multisite clickable modification based on the incorporation of azide moieties in proteins using lipoic acid ligase (LplA). The ligation of azide moieties to the model protein, green fluorescent protein (GFP), at the N-terminus and two internal sites using lipoic acid ligase was shown to proceed efficiently with near-complete conversion. Modification of the ligated azide groups with poly(ethylene glycol) (PEG), α-d-mannopyranoside, and palmitic acid resulted in highly homogeneous populations of protein-polymer, protein-sugar, and protein-fatty acid conjugates. The homogeneity of the conjugates was confirmed by mass spectrometry (MALDI-TOF) and SDS-PAGE electrophoresis. In the case of PEG attachment, which involved the use of strain-promoted azide-alkyne click chemistry, the conjugation reaction resulted in highly homogeneous PEG-GFP conjugates in less than 30 min. As further demonstration of the utility of this approach, ligated GFP was also covalently immobilized on alkyne-terminated self-assembled monolayers. These results underscore the potential of this approach for, among other applications, site-specific multipoint protein PEGylation, glycosylation, fatty acid modification, and protein immobilization.

  3. Multisite flooding hazard assessment in the Upper Mississippi River

    NASA Astrophysics Data System (ADS)

    Ghizzoni, Tatiana; Roth, Giorgio; Rudari, Roberto

    2012-01-01

    SummaryThis contribution presents an assessment of the joint probability distribution able to describe multi-site multi-basin flood scenarios in a high dimensionality framework. This goal will be pursued through two different approaches: the multivariate skew- t distribution and the Student copula with arbitrary margins. While copulas have been widely used in the modeling of hydrological processes, the use of the skew- t distribution in hydrology has been only recently proposed with reference to a trivariate application (Ghizzoni et al., 2010, Adv. Water Resour., 33, 1243-1255). Both methods are here applied and discussed in a context of considerably higher dimensionality: the Upper Mississippi River floods. In fact, to enhance the characteristics of the correlation structure, eighteen nested and non-nested gauging stations were selected, with significantly different contributing areas. Such conditions represent a challenge for both the skew- t and the copula approach. In perspective, the ability of such approaches in explaining the multivariate aspects of the relevant processes is needed to specify flood hazard scenarios in terms of their intensity, extension and frequency. When this is associated to the knowledge of location, value and vulnerability of exposed elements, comprehensive flood risk scenarios can be produced, and risk cumuli quantified, for given portfolios, composed of wherever located risks.

  4. Spectroscopic Classifications of Optical Transients with SOAR

    NASA Astrophysics Data System (ADS)

    Hounsell, R. A.; Miller, J. A.; Pan, Y.-C.; Foley, R. J.; Jha, S. W.; Rest, A.; Scolnic, D.; Smith, K. W.; Wright, D.; Smartt, S. J.; Huber, M.; Chambers, K. C.; Flewelling, H.; Willman, M.; Primak, N.; Schultz, A.; Gibson, B.; Magnier, E.; Waters, C.; Tonry, J.; Wainscoat, R. J.

    2016-06-01

    We report the following classifications of optical transients from spectroscopic observations with the Goodman spectrograph on the SOAR 4-m telescope. Targets were supplied by the Pan-STARRS Survey for Transients (PSST).

  5. Asiago spectroscopic classification of SN2017awk.

    NASA Astrophysics Data System (ADS)

    Tomasella, L.; Benetti, S.; Cappellaro, E.; Elias-Rosa, N.; Ochner; Pastorello, P.; Turatto, M.; Terreran, G

    2017-02-01

    The Asiago Transient Classification Program (Tomasella et al. 2014, AN, 335, 841) reports the spectroscopic observation of ASASSN-17co The target was supplied by All Sky Automated Survey for SuperNovae (ASAS-SN).

  6. A model of yeast cell-cycle regulation based on multisite phosphorylation

    PubMed Central

    Barik, Debashis; Baumann, William T; Paul, Mark R; Novak, Bela; Tyson, John J

    2010-01-01

    In order for the cell's genome to be passed intact from one generation to the next, the events of the cell cycle (DNA replication, mitosis, cell division) must be executed in the correct order, despite the considerable molecular noise inherent in any protein-based regulatory system residing in the small confines of a eukaryotic cell. To assess the effects of molecular fluctuations on cell-cycle progression in budding yeast cells, we have constructed a new model of the regulation of Cln- and Clb-dependent kinases, based on multisite phosphorylation of their target proteins and on positive and negative feedback loops involving the kinases themselves. To account for the significant role of noise in the transcription and translation steps of gene expression, the model includes mRNAs as well as proteins. The model equations are simulated deterministically and stochastically to reveal the bistable switching behavior on which proper cell-cycle progression depends and to show that this behavior is robust to the level of molecular noise expected in yeast-sized cells (∼50 fL volume). The model gives a quantitatively accurate account of the variability observed in the G1-S transition in budding yeast, which is governed by an underlying sizer+timer control system. PMID:20739927

  7. Complementary Therapies for Children Undergoing Stem Cell Transplant: Report of A Multisite Trial

    PubMed Central

    Phipps, Sean; Barrera, Maru; Vannatta, Kathryn; Xiong, Xiaoping; Doyle, John J; Alderfer, Melissa A.

    2010-01-01

    Background Children undergoing stem cell transplant (SCT) experience high levels of somatic distress and mood disturbance. This trial evaluated the efficacy of complementary therapies (massage, humor therapy, relaxation/imagery) for reducing distress associated with pediatric SCT. Methods Across 4 sites, 178 pediatric patients scheduled to undergo SCT were randomized to a child-targeted intervention involving massage and humor therapy (HPI-C), the identical child intervention plus a parent intervention involving massage and relaxation/imagery (HPI-CP) or standard care (SC). Randomization was stratified by site, age, and type of transplant. The interventions began at admission and continued through SCT week +3. Primary outcomes included patient and parent reports of somatic distress and mood disturbance obtained weekly from admission through week +6 using the BASES scales. Secondary outcomes included length of hospitalization, time to engraftment, and usage of narcotic analgesic and antiemetic medications. Results A mixed model approach was used to assess longitudinal trends of patient and parent-report outcomes and test differences between groups on these measures. Significant changes across time were observed on all patient and parent-report outcomes. However, no significant differences between treatment arms were found on the primary outcomes. Similarly, no signficant between group differences were noted on any of the medical variables as secondary outcomes. Conclusions Results of this multi-site trial failed to document significant benefits of complementary interventions in the pediatric SCT setting. PMID:20626016

  8. Coping Skills Among Adolescent Suicide Attempters: Results of a Multisite Study

    PubMed Central

    Mirkovic, Bojan; Labelle, Réal; Guilé, Jean-Marc; Belloncle, Vincent; Bodeau, Nicolas; Knafo, Alexandra; Condat, Agnès; Bapt-Cazalets, Nathalie; Marguet, Christophe; Breton, Jean-Jacques; Cohen, David; Gérardin, Priscille

    2015-01-01

    Objectives: A multisite study was undertaken to advance our understanding of how coping skills, depression, and suicidal ideation are related among adolescents who attempt suicide. Two hypotheses were postulated: productive coping and nonproductive coping would be associated, respectively, with lower and higher depression scores when age, sex, and stressful life events (SLEs) were controlled; and productive coping and nonproductive coping would be associated, respectively, with the presence and absence of suicidal ideation when age, sex, and SLEs were controlled. Methods: Participants were 167 adolescents (13 to 17 years of age) hospitalized for attempting suicide in 5 pediatric departments across France. Four instruments were administered: the Kiddie Schedule for Affective Disorders and Schizophrenia—Present and Lifetime Version, the Adolescent Coping Scale, the Life Events Questionnaire, and the Columbia-Suicide Severity Rating Scale. Descriptive analyses and univariate and multiple regression models were completed. Results: Both hypotheses were confirmed. Focus on the positive emerged as a significant variable in both models; depression emerged as a significant variable in the suicidal ideation model. The only sex difference observed was that girls made greater use of wishful thinking and seek social support. Conclusions: These findings suggest that coping skills are important mechanisms through which depression and suicidal ideation are maintained after attempting suicide. In intervening with adolescents who have attempted suicide, it may be useful to emphasize cognitive work geared to looking on the bright side, positive thinking, and fighting depression. PMID:25886670

  9. [Preanalytical phase and accreditation: acceptance criteria for samples of multisite laboratory].

    PubMed

    Dialma, Pascale; Piaulenne, Stéphane; Baty, Sonia; Zeitoun, Thierry

    2013-01-01

    Performing high quality analyses in order to help physicians in their diagnoses and to ensure better patient care: this represents our routine mission for clinical lab. To achieve this goal, all steps from sampling to the final data transfer must be controlled. The preanalytical phase is one of the most crucial, but also one of the most complicated, especially in the context of a consolidated laboratory network. Transport conditions, delays, temperature, regulatory constraints are all criteria that we need to take into consideration in order to comply to ISO 15189, section 5.4. In this context, our laboratory would like to address the following issues: to control the transport conditions in order to guarantee optimal preservation of the samples, and to define an internal process and identify non-conforming situations linked to delay in sample delivery. An original study dealing with the stability in whole blood of common clinical chemistry and immunochemistry tests in defined transport conditions (delays, temperature, tube position) was performed on a panel of 100 patients' samples. This panel is intended to be a good reflection of the patients usually seen in multi-site laboratory. We observed that most of the analytes (35 of 41) were stable in whole blood; however, some of them demonstrated instability over time. All these results were integrated into our collection manual.

  10. Multisite, multimodal neuroimaging of chronic urological pelvic pain: Methodology of the MAPP Research Network.

    PubMed

    Alger, Jeffry R; Ellingson, Benjamin M; Ashe-McNalley, Cody; Woodworth, Davis C; Labus, Jennifer S; Farmer, Melissa; Huang, Lejian; Apkarian, A Vania; Johnson, Kevin A; Mackey, Sean C; Ness, Timothy J; Deutsch, Georg; Harris, Richard E; Clauw, Daniel J; Glover, Gary H; Parrish, Todd B; Hollander, Jan den; Kusek, John W; Mullins, Chris; Mayer, Emeran A

    2016-01-01

    The Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP) Research Network is an ongoing multi-center collaborative research group established to conduct integrated studies in participants with urologic chronic pelvic pain syndrome (UCPPS). The goal of these investigations is to provide new insights into the etiology, natural history, clinical, demographic and behavioral characteristics, search for new and evaluate candidate biomarkers, systematically test for contributions of infectious agents to symptoms, and conduct animal studies to understand underlying mechanisms for UCPPS. Study participants were enrolled in a one-year observational study and evaluated through a multisite, collaborative neuroimaging study to evaluate the association between UCPPS and brain structure and function. 3D T1-weighted structural images, resting-state fMRI, and high angular resolution diffusion MRI were acquired in five participating MAPP Network sites using 8 separate MRI hardware and software configurations. We describe the neuroimaging methods and procedures used to scan participants, the challenges encountered in obtaining data from multiple sites with different equipment/software, and our efforts to minimize site-to-site variation.

  11. How Institutional and University Counselor Policies Effectively Respond to Victims of Cyber Violent Acts: A Multisite Case Study

    ERIC Educational Resources Information Center

    Richards, Gretchen M.

    2012-01-01

    This multisite case study examined how institutional and university counselor policies effectively respond to cyber violent acts. Stake's (2006) multisite case study methodology was used to identify seven themes from current literature. Two sites with four participants were selected. The participants included two counseling directors and the…

  12. Observation of the origin of d0 magnetism in ZnO nanostructures using X-ray-based microscopic and spectroscopic techniques.

    PubMed

    Singh, Shashi B; Wang, Yu-Fu; Shao, Yu-Cheng; Lai, Hsuan-Yu; Hsieh, Shang-Hsien; Limaye, Mukta V; Chuang, Chen-Hao; Hsueh, Hung-Chung; Wang, Hsaiotsu; Chiou, Jau-Wern; Tsai, Hung-Ming; Pao, Chih-Wen; Chen, Chia-Hao; Lin, Hong-Ji; Lee, Jyh-Fu; Wu, Chun-Te; Wu, Jih-Jen; Pong, Way-Faung; Ohigashi, Takuji; Kosugi, Nobuhiro; Wang, Jian; Zhou, Jigang; Regier, Tom; Sham, Tsun-Kong

    2014-08-07

    Efforts have been made to elucidate the origin of d(0) magnetism in ZnO nanocactuses (NCs) and nanowires (NWs) using X-ray-based microscopic and spectroscopic techniques. The photoluminescence and O K-edge and Zn L3,2-edge X-ray-excited optical luminescence spectra showed that ZnO NCs contain more defects than NWs do and that in ZnO NCs, more defects are present at the O sites than at the Zn sites. Specifically, the results of O K-edge scanning transmission X-ray microscopy (STXM) and the corresponding X-ray-absorption near-edge structure (XANES) spectroscopy demonstrated that the impurity (non-stoichiometric) region in ZnO NCs contains a greater defect population than the thick region. The intensity of O K-edge STXM-XANES in the impurity region is more predominant in ZnO NCs than in NWs. The increase in the unoccupied (occupied) density of states at/above (at/below) the conduction-band minimum (valence-band maximum) or the Fermi level is related to the population of defects at the O sites, as revealed by comparing the ZnO NCs to the NWs. The results of O K-edge and Zn L3,2-edge X-ray magnetic circular dichroism demonstrated that the origin of magnetization is attributable to the O 2p orbitals rather than the Zn d orbitals. Further, the local density approximation (LDA) + U verified that vacancies in the form of dangling or unpaired 2p states (due to Zn vacancies) induced a significant local spin moment in the nearest-neighboring O atoms to the defect center, which was determined from the uneven local spin density by analyzing the partial density of states of O 2p in ZnO.

  13. Middle-Eastern plant communities tolerate 9 years of drought in a multi-site climate manipulation experiment.

    PubMed

    Tielbörger, Katja; Bilton, Mark C; Metz, Johannes; Kigel, Jaime; Holzapfel, Claus; Lebrija-Trejos, Edwin; Konsens, Irit; Parag, Hadas A; Sternberg, Marcelo

    2014-10-06

    For evaluating climate change impacts on biodiversity, extensive experiments are urgently needed to complement popular non-mechanistic models which map future ecosystem properties onto their current climatic niche. Here, we experimentally test the main prediction of these models by means of a novel multi-site approach. We implement rainfall manipulations--irrigation and drought--to dryland plant communities situated along a steep climatic gradient in a global biodiversity hotspot containing many wild progenitors of crops. Despite the large extent of our study, spanning nine plant generations and many species, very few differences between treatments were observed in the vegetation response variables: biomass, species composition, species richness and density. The lack of a clear drought effect challenges studies classifying dryland ecosystems as most vulnerable to global change. We attribute this resistance to the tremendous temporal and spatial heterogeneity under which the plants have evolved, concluding that this should be accounted for when predicting future biodiversity change.

  14. A Comparison of Commonly Used Processes for Multi-Site Software Development

    NASA Astrophysics Data System (ADS)

    Avritzer, Alberto; Paulish, Daniel J.

    This chapter describes some commonly used multi-site software development processes and compares them with respect to the amount of coordination that they support across locations. Specifically, two common processes, called the "Extended Workbench Modelextended workbench model " and "System of Systems Modelsystem of systems model " will be compared based on our experience. The processes have each been experimentally applied over several years to a global development project, called the "Global Studio Project" (GSP) in which university students around the world have simulated the processes used for an industrial multi-site development project. Lessons learned will be discussed and guidance given for multi-site development projects based on our experience from experimental and real projects.

  15. Multisite comparison of high-sensitivity multiplex cytokine assays.

    PubMed

    Breen, Elizabeth Crabb; Reynolds, Sandra M; Cox, Christopher; Jacobson, Lisa P; Magpantay, Larry; Mulder, Candice B; Dibben, Oliver; Margolick, Joseph B; Bream, Jay H; Sambrano, Elise; Martínez-Maza, Otoniel; Sinclair, Elizabeth; Borrow, Persephone; Landay, Alan L; Rinaldo, Charles R; Norris, Philip J

    2011-08-01

    The concentrations of cytokines in human serum and plasma can provide valuable information about in vivo immune status, but low concentrations often require high-sensitivity assays to permit detection. The recent development of multiplex assays, which can measure multiple cytokines in one small sample, holds great promise, especially for studies in which limited volumes of stored serum or plasma are available. Four high-sensitivity cytokine multiplex assays on a Luminex (Bio-Rad, BioSource, Linco) or electrochemiluminescence (Meso Scale Discovery) platform were evaluated for their ability to detect circulating concentrations of 13 cytokines, as well as for laboratory and lot variability. Assays were performed in six different laboratories utilizing archived serum from HIV-uninfected and -infected subjects from the Multicenter AIDS Cohort Study (MACS) and the Women's Interagency HIV Study (WIHS) and commercial plasma samples spanning initial HIV viremia. In a majority of serum samples, interleukin-6 (IL-6), IL-8, IL-10, and tumor necrosis factor alpha were detectable with at least three kits, while IL-1β was clearly detected with only one kit. No single multiplex panel detected all cytokines, and there were highly significant differences (P < 0.001) between laboratories and/or lots with all kits. Nevertheless, the kits generally detected similar patterns of cytokine perturbation during primary HIV viremia. This multisite comparison suggests that current multiplex assays vary in their ability to measure serum and/or plasma concentrations of cytokines and may not be sufficiently reproducible for repeated determinations over a long-term study or in multiple laboratories but may be useful for longitudinal studies in which relative, rather than absolute, changes in cytokines are important.

  16. Patterns of multisite pain and associations with risk factors

    PubMed Central

    Coggon, David; Ntani, Georgia; Palmer, Keith T.; Felli, Vanda E.; Harari, Raul; Barrero, Lope H.; Felknor, Sarah A.; Gimeno, David; Cattrell, Anna; Vargas-Prada, Sergio; Bonzini, Matteo; Solidaki, Eleni; Merisalu, Eda; Habib, Rima R.; Sadeghian, Farideh; Masood Kadir, M.; Warnakulasuriya, Sudath S.P.; Matsudaira, Ko; Nyantumbu, Busisiwe; Sim, Malcolm R.; Harcombe, Helen; Cox, Ken; Marziale, Maria H.; Sarquis, Leila M.; Harari, Florencia; Freire, Rocio; Harari, Natalia; Monroy, Magda V.; Quintana, Leonardo A.; Rojas, Marianela; Salazar Vega, Eduardo J.; Harris, E. Clare; Serra, Consol; Martinez, J. Miguel; Delclos, George; Benavides, Fernando G.; Carugno, Michele; Ferrario, Marco M.; Pesatori, Angela C.; Chatzi, Leda; Bitsios, Panos; Kogevinas, Manolis; Oha, Kristel; Sirk, Tuuli; Sadeghian, Ali; Peiris-John, Roshini J.; Sathiakumar, Nalini; Wickremasinghe, A. Rajitha; Yoshimura, Noriko; Kelsall, Helen L.; Hoe, Victor C.W; Urquhart, Donna M.; Derrett, Sarah; McBride, David; Herbison, Peter; Gray, Andrew

    2013-01-01

    To explore definitions for multisite pain, and compare associations with risk factors for different patterns of musculoskeletal pain, we analysed cross-sectional data from the Cultural and Psychosocial Influences on Disability (CUPID) study. The study sample comprised 12,410 adults aged 20–59 years from 47 occupational groups in 18 countries. A standardised questionnaire was used to collect information about pain in the past month at each of 10 anatomical sites, and about potential risk factors. Associations with pain outcomes were assessed by Poisson regression, and characterised by prevalence rate ratios (PRRs). Extensive pain, affecting 6–10 anatomical sites, was reported much more frequently than would be expected if the occurrence of pain at each site were independent (674 participants vs 41.9 expected). In comparison with pain involving only 1–3 sites, it showed much stronger associations (relative to no pain) with risk factors such as female sex (PRR 1.6 vs 1.1), older age (PRR 2.6 vs 1.1), somatising tendency (PRR 4.6 vs 1.3), and exposure to multiple physically stressing occupational activities (PRR 5.0 vs 1.4). After adjustment for number of sites with pain, these risk factors showed no additional association with a distribution of pain that was widespread according to the frequently used American College of Rheumatology criteria. Our analysis supports the classification of pain at multiple anatomical sites simply by the number of sites affected, and suggests that extensive pain differs importantly in its associations with risk factors from pain that is limited to only a small number of anatomical sites. PMID:23727463

  17. Spectroscopic characterization of the isolated SF6- and C4F8- anions: observation of very long harmonic progressions in symmetric deformation modes upon photodetachment.

    PubMed

    Bopp, Joseph C; Roscioli, Joseph R; Johnson, Mark A; Miller, Thomas M; Viggiano, A A; Villano, Stephanie M; Wren, Scott W; Lineberger, W Carl

    2007-02-22

    Spectroscopic studies of the SF6- and c-C4F8- anions are reported to provide experimental benchmarks for theoretical predictions of their structures and electron binding energies. The photoelectron spectrum of SF6- is dominated by a long progression in the S-F stretching mode, with an envelope consistent with theoretical predictions that the anion preserves the Oh symmetry of the neutral, but has a longer S-F bond length. This main progression occurs with an unexpectedly strong contribution from a second mode, however, whose characteristic energy does not correspond to any of the neutral SF6 fundamental vibrations in its ground electronic state. The resulting doublet pattern is evident when the bare ion is prepared with low internal energy content (i.e., using N2 carrier gas in a free jet or liquid nitrogen-cooling in a flowing afterglow) but is much better resolved in the spectrum of the SF6-.Ar complex. The infrared predissociation spectrum of SF6-.Ar consists of a strong band at 683(5) cm(-1), which we assign to the nu3 (t1u) fundamental, the same mode that yields the strong 948 cm(-1) infrared transition in neutral SF6. One qualitatively interesting aspect of the SF6- behavior is the simple structure of its photoelectron spectrum, which displays uncluttered, harmonic bands in an energy region where the neutral molecule contains about 2 eV of vibrational excitation. We explore this effect further in the c-C4F8- anion, which also presents a system that is calculated to undergo large, symmetrical distortion upon electron attachment to the neutral. The photoelectron spectrum of this species is dominated by a long, single vibrational progression, this time involving the symmetric ring-breathing mode. Like the SF6- case, the c-C4F8- spectrum is remarkably isolated and harmonic in spite of the significant internal excitation of a relatively complex molecular framework. Both these perfluorinated anions thus share the property that the symmetrical deformation of the

  18. Tools and Methods for Risk Management in Multi-Site Engineering Projects

    NASA Astrophysics Data System (ADS)

    Zhou, Mingwei; Nemes, Laszlo; Reidsema, Carl; Ahmed, Ammar; Kayis, Berman

    In today's highly global business environment, engineering and manufacturing projects often involve two or more geographically dispersed units or departments, research centers or companies. This paper attempts to identify the requirements for risk management in a multi-site engineering project environment, and presents a review of the state-of-the-art tools and methods that can be used to manage risks in multi-site engineering projects. This leads to the development of a risk management roadmap, which will underpin the design and implementation of an intelligent risk mapping system.

  19. Spectroscopic measurements of solar wind generation

    NASA Technical Reports Server (NTRS)

    Kohl, J. L.; Withbroe, G. L.; Zapata, C. A.; Noci, G.

    1983-01-01

    Spectroscopically observable quantities are described which are sensitive to the primary plasma parameters of the solar wind's source region. The method is discussed in which those observable quantities are used as constraints in the construction of empirical models of various coronal structures. Simulated observations are used to examine the fractional contributions to observed spectral intensities from coronal structures of interest which co-exist with other coronal structures along simulated lines-of-sight. The sensitivity of spectroscopic observables to the physical parameters within each of those structures is discussed.

  20. Single nanoparticle tracking spectroscopic microscope

    DOEpatents

    Yang, Haw; Cang, Hu; Xu, Cangshan; Wong, Chung M.

    2011-07-19

    A system that can maintain and track the position of a single nanoparticle in three dimensions for a prolonged period has been disclosed. The system allows for continuously imaging the particle to observe any interactions it may have. The system also enables the acquisition of real-time sequential spectroscopic information from the particle. The apparatus holds great promise in performing single molecule spectroscopy and imaging on a non-stationary target.

  1. Observation

    ERIC Educational Resources Information Center

    Helfrich, Shannon

    2016-01-01

    Helfrich addresses two perspectives from which to think about observation in the classroom: that of the teacher observing her classroom, her group, and its needs, and that of the outside observer coming into the classroom. Offering advice from her own experience, she encourages and defends both. Do not be afraid of the disruption of outside…

  2. Observations

    ERIC Educational Resources Information Center

    Joosten, Albert Max

    2016-01-01

    Joosten begins his article by telling us that love and knowledge together are the foundation for our work with children. This combination is at the heart of our observation. With this as the foundation, he goes on to offer practical advice to aid our practice of observation. He offers a "List of Objects of Observation" to help guide our…

  3. Ground state dissociation pathways for 3,4,-dichloro-1,2,5-thiadiazole: Spectroscopic observation and fate of NCsbnd C(Cl2)sbnd Ndbnd S isomer

    NASA Astrophysics Data System (ADS)

    Srinivas, D.; Upadhyaya, Hari P.

    2016-09-01

    Photodissociation pathways for 3,4-dichloro-1,2,5-thiadiazole was investigated in its ground state at various wavelengths in the UV region. The photolysis products were identified by the UV absorption and emission spectroscopy. Molecular chlorine (Cl2) elimination was observed using absorption methods in the UV region. UV absorption and quantum calculation confirms the migration of chlorine atom and subsequent ring opening to form NCsbnd C(Cl2)sbnd Ndbnd S isomer. Multiphotonic excitation leading to the UV emission in the vicinity of 389 nm was observed due to the formation of CN(B2Σ+) moiety. New UV absorption bands observed at ∼255 and ∼290 nm were assigned to the its isomer NCsbnd C(Cl2)sbnd Ndbnd S.

  4. Positive Family Intervention for Severe Challenging Behavior I: A Multisite Randomized Clinical Trial

    ERIC Educational Resources Information Center

    Durand, V. Mark; Hieneman, Meme; Clarke, Shelley; Wang, Mo; Rinaldi, Melissa L.

    2013-01-01

    The present study was a multisite randomized clinical trial assessing the effects of adding a cognitive-behavioral intervention to positive behavior support (PBS). Fifty-four families who met the criteria of (a) having a child with a developmental disability, (b) whose child displayed serious challenging behavior (e.g., aggression, self-injury,…

  5. Learning about and from a Distribution of Program Impacts Using Multisite Trials

    ERIC Educational Resources Information Center

    Raudenbush, Stephen W.; Bloom, Howard S.

    2015-01-01

    The present article provides a synthesis of the conceptual and statistical issues involved in using multisite randomized trials to learn about and from a distribution of heterogeneous program impacts across individuals and/or program sites. Learning "about" such a distribution involves estimating its mean value, detecting and quantifying…

  6. Documenting the Impact of Multisite Evaluations on the Science, Technology, Engineering, and Mathematics Field

    ERIC Educational Resources Information Center

    Roseland, Denise; Greenseid, Lija O.; Volkov, Boris B.; Lawrenz, Frances

    2011-01-01

    This chapter discusses the impact that four multisite National Science Foundation (NSF) evaluations had on the broader field of science, technology, engineering, and mathematics education and evaluation. Three approaches were used to investigate the broader impact of these evaluations on the field: (a) a citation analysis, (b) an on-line survey,…

  7. Brief Treatments for Cannabis Dependence: Findings From a Randomized Multisite Trial

    ERIC Educational Resources Information Center

    Babor, Thomas F.

    2004-01-01

    This study evaluated the efficacy of 2 brief interventions for cannabis-dependent adults. A multisite randomized controlled trial compared cannabis use outcomes across 3 study conditions: (a) 2 sessions of motivational enhancement therapy (MET); (b) 9 sessions of multicomponent therapy that included MET, cognitive-behavioral therapy, and case…

  8. Finding Efficiency in the Design of Large Multisite Evaluations: Estimating Variances for Science Achievement Studies

    ERIC Educational Resources Information Center

    Westine, Carl D.

    2016-01-01

    Little is known empirically about intraclass correlations (ICCs) for multisite cluster randomized trial (MSCRT) designs, particularly in science education. In this study, ICCs suitable for science achievement studies using a three-level (students in schools in districts) MSCRT design that block on district are estimated and examined. Estimates of…

  9. Intraclass Correlations for Three-Level Multi-Site Cluster-Randomized Trials of Science Achievement

    ERIC Educational Resources Information Center

    Westine, Carl D.

    2015-01-01

    A cluster-randomized trial (CRT) relies on random assignment of intact clusters to treatment conditions, such as classrooms or schools (Raudenbush & Bryk, 2002). One specific type of CRT, a multi-site CRT (MSCRT), is commonly employed in educational research and evaluation studies (Spybrook & Raudenbush, 2009; Spybrook, 2014; Bloom,…

  10. Multi-Site Ethnography, Hypermedia and the Productive Hazards of Digital Methods: A Struggle for Liveness

    ERIC Educational Resources Information Center

    Gallagher, Kathleen; Freeman, Barry

    2011-01-01

    This article explores the possibilities and frustrations of using digital methods in a multi-sited ethnographic research project. The project, "Urban School Performances: The interplay, through live and digital drama, of local-global knowledge about student engagement", is a study of youth and teachers in drama classrooms in contexts of…

  11. A Multisite Randomized Effectiveness Trial of Motivational Enhancement Therapy for Spanish-Speaking Substance Users

    ERIC Educational Resources Information Center

    Carroll, Kathleen M.; Martino, Steve; Ball, Samuel A.; Nich, Charla; Frankforter, Tami; Anez, Luis M.; Paris, Manuel; Suarez-Morales, Lourdes; Szapocznik, Jose; Miller, William R.; Rosa, Carmen; Matthews, Julie; Farentinos, Chris

    2009-01-01

    Hispanic individuals are underrepresented in clinical and research populations and are often excluded from clinical trials in the United States. Hence, there are few data on the effectiveness of most empirically validated therapies for Hispanic substance users. The authors conducted a multisite randomized trial comparing the effectiveness of 3…

  12. A Multisite Psychotherapy and Medication Trial for Depressed Adolescents: Background and Benefits

    ERIC Educational Resources Information Center

    Kratochvil, Christopher J.; Simons, Anne; Vitiello, Benedetto; Walkup, John; Emslie, Graham; Rosenberg, David; March, John S.

    2005-01-01

    The Treatment for Adolescents With Depression Study (TADS) is an NIMH-supported multisite clinical trial that compares the effectiveness of a depression-specific cognitive behavioral therapy (CBT), medication management with fluoxetine (FLX), the combination of CBT and FLX (COMB), and medical management with pill placebo (PBO). TADS was…

  13. A Qualitative Multi-Site Case Study: Examining Principals' Leadership Styles and School Performance

    ERIC Educational Resources Information Center

    Preyear, Loukisha

    2015-01-01

    The purpose of this qualitative multi-site case study was to explore the impact of principals' leadership styles on student academic achievement in a high-poverty low-performing school district in Louisiana. A total of 17 participants, principals and teachers, from this school district were used in this study. Data source triangulation of…

  14. Statistical Analysis for Multisite Trials Using Instrumental Variables with Random Coefficients

    ERIC Educational Resources Information Center

    Raudenbush, Stephen W.; Reardon, Sean F.; Nomi, Takako

    2012-01-01

    Multisite trials can clarify the average impact of a new program and the heterogeneity of impacts across sites. Unfortunately, in many applications, compliance with treatment assignment is imperfect. For these applications, we propose an instrumental variable (IV) model with person-specific and site-specific random coefficients. Site-specific IV…

  15. Predicting changes in protein thermostability brought about by single- or multi-site mutations

    PubMed Central

    2010-01-01

    Background An important aspect of protein design is the ability to predict changes in protein thermostability arising from single- or multi-site mutations. Protein thermostability is reflected in the change in free energy (ΔΔG) of thermal denaturation. Results We have developed predictive software, Prethermut, based on machine learning methods, to predict the effect of single- or multi-site mutations on protein thermostability. The input vector of Prethermut is based on known structural changes and empirical measurements of changes in potential energy due to protein mutations. Using a 10-fold cross validation test on the M-dataset, consisting of 3366 mutants proteins from ProTherm, the classification accuracy of random forests and the regression accuracy of random forest regression were slightly better than support vector machines and support vector regression, whereas the overall accuracy of classification and the Pearson correlation coefficient of regression were 79.2% and 0.72, respectively. Prethermut performs better on proteins containing multi-site mutations than those with single mutations. Conclusions The performance of Prethermut indicates that it is a useful tool for predicting changes in protein thermostability brought about by single- or multi-site mutations and will be valuable in the rational design of proteins. PMID:20598148

  16. Testing the Feasibility of Fidelity Evaluation in a Multisite, Multiprogram Initiative

    ERIC Educational Resources Information Center

    Cornish, Disa Lubker; Losch, Mary E.; Avery, Mitchell

    2016-01-01

    Monitoring fidelity of implementation is a critical task when initiating evidence-based programs. This pilot study sought to identify best practices in a fidelity monitoring process and determine the feasibility of continuing a fidelity monitoring process with a multisite, multiprogram initiative. A fidelity log was created for each of 11…

  17. Power Calculations for Moderators in Multi-Site Cluster Randomized Trials

    ERIC Educational Resources Information Center

    Spybrook, Jessaca; Kelcey, Ben; Dong, Nianbo

    2016-01-01

    Cluster randomized trials (CRTs), or studies in which intact groups of individuals are randomly assigned to a condition, are becoming more common in evaluation studies of educational programs. A specific type of CRT in which clusters are randomly assigned to treatment within blocks or sites, known as multisite cluster randomized trials (MSCRTs),…

  18. Observation

    ERIC Educational Resources Information Center

    Kripalani, Lakshmi A.

    2016-01-01

    The adult who is inexperienced in the art of observation may, even with the best intentions, react to a child's behavior in a way that hinders instead of helping the child's development. Kripalani outlines the need for training and practice in observation in order to "understand the needs of the children and...to understand how to remove…

  19. Direct spectroscopic observation of a brewer's yeast pyruvate decarboxylase-bound enamine intermediate produced from a suicide substrate. Evidence for nonconcerted decarboxylation.

    PubMed

    Kuo, D J; Jordan, F

    1983-11-25

    The conjugated alpha-keto acid (E)-4-(4-chlorophenyl)-2-oxo-3-butenoic acid, a suicide substrate (Kuo, D. J., and Jordan, F. (1983) Biochemistry 22, 3735-3740), when reacted with brewer's yeast pyruvate decarboxylase (EC 4.1.1.1), was found to produce a new absorption band centered at 440 nm. The band was attributed to the formation of a thiamindiphosphate-bound intermediate produced upon decarboxylation and was not observed in the absence of either thiamindiphosphate or apoprotein. Simultaneously, with the appearance of the spectral band, the enzyme was inactivated irreversibly. The combined evidence suggested that the spectral band pertains to an enzyme-bound conjugated enamine and the results constitute the first direct observation of such an intermediate in any thiamindiphosphate requiring enzymatic reaction. It could be concluded that for the alpha-keto acid employed, CO2 loss and C-protonation of the enamine take place in a stepwise, rather than concerted, manner and that the steps culminating in CO2 loss are faster overall than the subsequent steps that lead to the release of the product. The observation of stoichiometric concentration of enzyme-bound enamine intermediate supports the previous suggestion that alpha-hydroxyethyl thiamindiphosphate is not the true intermediate, but rather the enamine is (Ullrich, J., and Mannshreck, A. (1967) Eur. J. Biochem 1, 110-116).

  20. Knockout, Transfer and Spectroscopic Factors

    NASA Astrophysics Data System (ADS)

    Kemper, Kirby; Keeley, Nicholas; Rusek, Krzysztof

    2011-10-01

    As derived quantities rather than observables, spectroscopic factors extracted from fits to data are model dependent. The main source of uncertainty is the choice of binding potential, but other factors such as adequate modeling of the reaction mechanism, the Perey effect, choice of distorting nuclear potentials etc. can also play a significant role. Recently, there has been some discussion of apparent discrepancies in spectroscopic factors derived from knockout reactions compared to those obtained from low-energy direct reactions. It should be possible to reconcile these discrepancies and we explore this prospect by attempting to describe the 10Be(d,t)9Be data of Nucl. Phys. A157, 305 (1970) using the 10Be/9Be form factors from a recent knockout study, Phys. Rev. Lett. 106, 162502 (2011). The influence of such factors as choice of distorting potentials and multi-step reactions paths will be explored.

  1. Multisite Parent-Centered Risk Assessment to Reduce Pediatric Oral Chemotherapy Errors

    PubMed Central

    Walsh, Kathleen E.; Mazor, Kathleen M.; Roblin, Douglas; Biggins, Colleen; Wagner, Joann L.; Houlahan, Kathleen; Li, Justin W.; Keuker, Christopher; Wasilewski-Masker, Karen; Donovan, Jennifer; Kanaan, Abir; Weingart, Saul N.

    2013-01-01

    Purpose: Observational studies describe high rates of errors in home oral chemotherapy use in children. In hospitals, proactive risk assessment methods help front-line health care workers develop error prevention strategies. Our objective was to engage parents of children with cancer in a multisite study using proactive risk assessment methods to identify how errors occur at home and propose risk reduction strategies. Methods: We recruited parents from three outpatient pediatric oncology clinics in the northeast and southeast United States to participate in failure mode and effects analyses (FMEA). An FMEA is a systematic team-based proactive risk assessment approach in understanding ways a process can fail and develop prevention strategies. Steps included diagram the process, brainstorm and prioritize failure modes (places where things go wrong), and propose risk reduction strategies. We focused on home oral chemotherapy administration after a change in dose because prior studies identified this area as high risk. Results: Parent teams consisted of four parents at two of the sites and 10 at the third. Parents developed a 13-step process map, with two to 19 failure modes per step. The highest priority failure modes included miscommunication when receiving instructions from the clinician (caused by conflicting instructions or parent lapses) and unsafe chemotherapy handling at home. Recommended risk assessment strategies included novel uses of technology to improve parent access to information, clinicians, and other parents while at home. Conclusion: Parents of pediatric oncology patients readily participated in a proactive risk assessment method, identifying processes that pose a risk for medication errors involving home oral chemotherapy. PMID:23633976

  2. Predicting diffuse light-enhancement of GPP from plant functional traits: A multi-site synthesis

    NASA Astrophysics Data System (ADS)

    O'Halloran, T. L.; Barr, J. G.; Cook, B.; Goeckede, M.; Law, B. E.; Kueppers, L. M.; Riley, W. J.

    2013-12-01

    Diffuse light enhances canopy-scale photosynthesis because isotropic diffuse light penetrates deeper into the canopy, involves more leaf area in photosynthesis, and prevents the top of the canopy from becoming light saturated. However, the observational and modeling communities still have little understanding of how the 'Diffuse light Enhancement Effect' (DEE) varies across plant functional types or is constrained by factors such as nitrogen availability and plant structure. So far, variability in the strength of DEE across plant functional types (PFTs) remains poorly constrained, but canopy models indicate leaf area index (LAI) is a primary controller. While the very few existing multi-site, measurement-based syntheses of the DEE have provided valuable information on the variability of the DEE across a few plant functional types, no study has correlated measured metrics of DEE magnitude with direct measurements of canopy physical traits across a wide range of plant functional types. Here we report a new metric that is suitable for quantifying the DEE in both flux measurements and land surface models. We also present, for the first time, an examination of the relationship between the DEE metric and plant functional traits. Results from our 70+ site AmeriFlux and FLUXNET synthesis indicate that LAI is the strongest controller of the DEE across sites and PFTs, with less significant influences from foliar nitrogen, canopy height, and mean annual precipitation. Our results will enable direct evaluation and improvement of remote sensing algorithms and light use efficiency models (e.g. MODIS GPP), which to this point regard diffuse light fraction as a source of noise. Additionally, improving resolution of the DEE in prognostic land surface models, such as the Community Land Model (CLM), will greatly improve our ability to forecast future feedbacks to terrestrial carbon sequestration from changes in cloudiness and aerosol amount.

  3. Candidate Water Vapor Lines to Locate the H2O Snowline through High-dispersion Spectroscopic Observations. II. The Case of a Herbig Ae Star

    NASA Astrophysics Data System (ADS)

    Notsu, Shota; Nomura, Hideko; Ishimoto, Daiki; Walsh, Catherine; Honda, Mitsuhiko; Hirota, Tomoya; Millar, T. J.

    2017-02-01

    Observationally measuring the location of the {{{H}}}2{{O}} snowline is crucial for understanding planetesimal and planet formation processes, and the origin of water on Earth. In disks around Herbig Ae stars (T * ∼ 10,000 K, M * ≳ 2.5M ⊙), the position of the {{{H}}}2{{O}} snowline is farther from the central star compared with that around cooler and less massive T Tauri stars. Thus, the {{{H}}}2{{O}} emission line fluxes from the region within the {{{H}}}2{{O}} snowline are expected to be stronger. In this paper, we calculate the chemical composition of a Herbig Ae disk using chemical kinetics. Next, we calculate the {{{H}}}2{{O}} emission line profiles and investigate the properties of candidate water lines across a wide range of wavelengths (from mid-infrared to submillimeter) that can locate the position of the {{{H}}}2{{O}} snowline. Those lines identified have small Einstein A coefficients (∼ {10}-6{--}{10}-3 s‑1) and relatively high upper-state energies (∼1000 K). The total fluxes tend to increase with decreasing wavelengths. We investigate the possibility of future observations (e.g., ALMA, SPICA/SMI-HRS) locating the position of the {{{H}}}2{{O}} snowline. Since the fluxes of those identified lines from Herbig Ae disks are stronger than those from T Tauri disks, the possibility of a successful detection is expected to increase for a Herbig Ae disk.

  4. Resolving Spectral Lines with a Periscope-Type DVD Spectroscope

    ERIC Educational Resources Information Center

    Wakabayashi, Fumitaka

    2008-01-01

    A new type of DVD spectroscope, the periscope type, is described and the numerical analysis of the observed emission and absorption spectra is demonstrated. A small and thin mirror is put inside and an eighth part of a DVD is used as a grating. Using this improved DVD spectroscope, one can observe and photograph visible spectra more easily and…

  5. Spectroscopic far ultraviolet observations of transition zone instabilities and their possible role in a pre-flare energy build-up

    NASA Technical Reports Server (NTRS)

    Brueckner, G. E.; Patterson, N. P.; Scherrer, V. E.

    1976-01-01

    Highly flare-productive newly emerging active regions are characterized by numerous small low-lying loops which frequently show a chaotic pattern. Flare activity in such a region subsides as the chaotic loop structures relax and expand into a bipolar configuration. The transition zone in such an active region is highly unstable, as shown by broadened and shifted nonthermal line profiles of medium-ionized elements like Si III, Si IV, and C IV. These transition-zone instabilities, which occur as isolated events in active regions of low flare productivity, are often observed prior to flares. Transition-zone instabilities can be traced to the footpoints of active loops and seem to be accompanied by heating of the loop. The loops vary in size and show differing degrees of activity, with the brightest and most compact ones seemingly being in a pre-flare state which results in the catastrophic energy release along the loop during a flare.

  6. Spectroscopic optical coherence elastography.

    PubMed

    Adie, Steven G; Liang, Xing; Kennedy, Brendan F; John, Renu; Sampson, David D; Boppart, Stephen A

    2010-12-06

    We present an optical technique to image the frequency-dependent complex mechanical response of a viscoelastic sample. Three-dimensional hyperspectral data, comprising two-dimensional B-mode images and a third dimension corresponding to vibration frequency, were acquired from samples undergoing external mechanical excitation in the audio-frequency range. We describe the optical coherence tomography (OCT) signal when vibration is applied to a sample and detail the processing and acquisition techniques used to extract the local complex mechanical response from three-dimensional data that, due to a wide range of vibration frequencies, possess a wide range of sample velocities. We demonstrate frequency-dependent contrast of the displacement amplitude and phase of a silicone phantom containing inclusions of higher stiffness. Measurements of an ex vivo tumor margin demonstrate distinct spectra between adipose and tumor regions, and images of displacement amplitude and phase demonstrated spatially-resolved contrast. Contrast was also observed in displacement amplitude and phase images of a rat muscle sample. These results represent the first demonstration of mechanical spectroscopy based on B-mode OCT imaging. Spectroscopic optical coherence elastography (S-OCE) provides a high-resolution imaging capability for the detection of tissue pathologies that are characterized by a frequency-dependent viscoelastic response.

  7. Spectroscopic Observation of the Stardust Re-Entry in the Near UV with SLIT: Deduction of Surface Temperatures and Plasma Radiation

    NASA Technical Reports Server (NTRS)

    Winter, Michael W.; Trumble, Kerry A.

    2010-01-01

    Thermal radiation of the heat-shield and the emission of the post-shock layer around the Stardust capsule, during its re-entry, were detected by a NASA-led observation campaign aboard NASA's DC-8 airborne observatory involving teams from several nations. The German SLIT experiment used a conventional spectrometer, in a Czerny-Turner configuration (300 mm focal length and a 600 lines/mm grating), fed by fiber optics, to cover a wavelength range from 324 nm to 456 nm with a pixel resolution of 0.08 nm. The reentering spacecraft was tracked m uansuinaglly a camera with a view angle of 20 degrees, and light from the capsule was collected using a small mirror telescope with a view angle of only 0.45 degrees. Data were gathered with a measurement frequency of 5 Hz in a 30-second time interval around the point of maximum heating until the capsule left the field of view. The emission of CN (as a major ablation product), N2(+) and different atoms were monitored successfully during that time. Due to the nature of the experimental set up, spatial resolution of the radiation field was not possible. Therefore, all measured values represent an integration of radiation from the visible part of the glowing heat shield, and from the plasma in the post-shock region. Further, due to challenges in tracking not every spectrum gathered contained data. The measured spectra can be split up into two parts: (i) continuum spectra which represent a superposition of the heat shield radiation and the continuum radiation of potential dust particles in the plasma, and (ii) line spectra from the plasma in the shock layer. Planck temperatures (interpreted as the surface temperatures of the Stardust heat shield) were determined assuming either a constant surface temperature, or a temperature distribution deduced from numerical simulation. The constant surface temperatures are in good agreement with numerical simulations, but the peak values at the stagnation point are significantly lower than those

  8. Asiago spectroscopic classification of SN 2017ati.

    NASA Astrophysics Data System (ADS)

    Benetti, S.; Tomasella, L.; Cappellaro, E.; Elias-Rosa, N.; Ochner, P.; Pastorello, A.; Turatto, M.; Terreran, G.

    2017-02-01

    The Asiago Transient Classification Program (Tomasella et al. 2014, AN, 335, 841) reports the spectroscopic observation of Gaia17aiq. The target was supplied by Gaia Photometric Science Alerts programme . The observation was performed with the Asiago 1.82m Copernico Telescope (+AFOSC; range 340-820 nm; resolution 1.4 nm). Survey name | IAU name | Host galaxy | Disc.

  9. Asiago spectroscopic classification of ASASSN-15db

    NASA Astrophysics Data System (ADS)

    Ochner, P.; Pastorello, A.; Benetti, S.; Cappellaro, E.; Elias-Rosa, N.; Tartaglia, L.; Terreran, G.; Tomasella, L.; Turatto, M.

    2015-02-01

    The Asiago Transient Classification Program (Tomasella et al. 2014, AN, 335, 841) reports the spectroscopic observation of ASASSN-15db in NGC 5996. The observation was performed with the Asiago 1.82m Copernico Telescope (+AFOSC; range 340-820 nm; resolution 1.4 nm), equipped with the CCD Andor IKON L936.

  10. Spectroscopic observations of 14N/15N ratios in both NH2 and CN in comet C/2013 US10 (Catalina)

    NASA Astrophysics Data System (ADS)

    Shinnaka, Yoshiharu; Kawakita, Hideyo

    2016-10-01

    Comet is one of the primordial small bodies in the solar system and probably it has kept the information about the evolution of materials from the pre-solar molecular cloud to the solar nebula.Isotopic ratio in volatiles is one of the primordial properties of comets. A heavier isotopes trend to be captured into a molecule by chemical reactions under very low-temperature conditions (called as fractionation). For instance, D/H ratio of water (HDO/H2O) in comet is enriched in D atom than the elemental abundance ratios of D/H in entire solar system [1]. Based on the observed D/H ratios in cometary water, a presumed temperature is ~20-50 K as the formation temperature of water (most abundant volatiles in cometary nucleus), by assuming water formed in gas-phase chemistry [2].Besides, the nitrogen isotopic ratios (14N/15N) have been determined from CN and HCN (which is believed a dominant "parent" species of CN in the coma) in >20 comets [3,4]. They demonstrated cometary HCN and CN show high 15N-fractionation with respect to the proto-solar value by a factor of ~3 and with a small diversity. Moreover, 14N/15N ratios in NH3 in comets has been determined from intensity ratios of NH2 isotopologues [5,6,7], and both 15N-fractionation as much as HCN in comets and a small diversity are seen in those 14N/15N ratios in NH3. However, there is a few reports about 14N/15N ratios in both HCN and NH3 in the same comets, and discussions about the relationship between these 14N/15N ratios have not been yet.We present 14N/15N ratios in both NH2 and CN in comet C/2013 US10 (Catalina). High-resolution optical spectra of the comet were taken with the HDS spectrograph mounted on the Subaru Telescope (Hawaii) on UT 2016 January 2-3. We will discuss about the origins of these volatiles based on the 14N/15N ratios.This work was supported by Graint-in-Aid for JSPS Fellows, 15J10864 (YS).References:[1] Lis et al., 2013, ApJ 774, L3[2] Millar et al., 1989, ApJ 340, 906[3] Bockelée-Morvan et al

  11. Synchrotron-based far-infrared spectroscopic investigation and ab initio calculations of 3-oxetanone: observation and analysis of the ν7 band and the Coriolis coupled ν16 and ν20 bands.

    PubMed

    Chen, Ziqiu; van Wijngaarden, Jennifer

    2012-09-27

    Rotationally resolved vibrational spectra of the four-membered heterocycle 3-oxetanone (c-C(3)H(4)O(2)) have been investigated in the 360-720 cm(-1) region with a resolution of 0.000 959 cm(-1) using synchrotron radiation from the Canadian Light Source. The observed bands correspond to motions best described as C═O deformation out-of-plane (ν(20)) at 399.6 cm(-1), C═O deformation in-plane (ν(16)) at 448.2 cm(-1), and the ring deformation (ν(7)) at 685.0 cm(-1). Infrared ground state combination differences along with previously reported pure rotational transitions were used to obtain the ground state spectroscopic parameters. Band centers, rotational and centrifugal distortion constants for the ν(7), ν(16), and ν(20) vibrational excited states were accurately determined by fitting a total of 10,319 assigned rovibrational transitions in a global analysis. The two adjacent carbonyl deformation bands, ν(16) and ν(20), were found to be mutually perturbed through a first-order a-type Coriolis interaction which was accounted for in the multiband analysis. The band centers agree within 3% of the ab initio estimates using DFT theory.

  12. High-energy spectroscopic astrophysics

    NASA Astrophysics Data System (ADS)

    Güdel, Manuel; Walter, Roland

    After three decades of intense research in X-ray and gamma-ray astronomy, the time was ripe to summarize basic knowledge on X-ray and gamma-ray spectroscopy for interested students and researchers ready to become involved in new high-energy missions. This volume exposes both the scientific basics and modern methods of high-energy spectroscopic astrophysics. The emphasis is on physical principles and observing methods rather than a discussion of particular classes of high-energy objects, but many examples and new results are included in the three chapters as well.

  13. Solution of the antiferromagnetic Ising model with multisite interaction on a zigzag ladder.

    PubMed

    Jurčišinová, E; Jurčišin, M

    2014-09-01

    We consider the antiferromagnetic spin-1/2 Ising model with multisite interaction in an external magnetic field on an infinite zigzag ladder. The model is solved exactly by using the transfer matrix method. Using the exact expression for the total magnetization per site, the magnetic properties of the model are investigated in detail. The model exhibits the formation of magnetization plateaus for low temperatures, and it is shown that their properties depend strongly on the strength of the multisite interaction. All possible ground states of the model are found and discussed. The existence of nontrivial singular ground states is proven and exact explicit expressions for them are found. The macroscopic degeneracy of the ground states is investigated and discussed.

  14. MASCARA: the multi-site all-sky CAameRA: concept and first results

    NASA Astrophysics Data System (ADS)

    Lesage, A.-L.; Spronck, J. F. P.; Stuik, R.; Bettonvil, F.; Pollaco, D.; Snellen, I. A. G.

    2014-07-01

    MASCARA, the Multi-site All-Sky CAmeRA, will consist of several fully-automated stations distributed across the globe. Its goal is to find exoplanets transiting the brightest stars, in the mV = 4 to 8 magnitude range, currently probed neither by space- nor by ground-based surveys. The nearby transiting planet systems that MASCARA is expected to discover will be key targets for future detailed planet atmosphere observations. The target population for MASCARA consists mostly of hot Jupiters. The main requirement set on MASCARA to detect these planets around stars down to magnitude 8 is to reach a minimum Signal-to-Noise Ratio of 100 within one hour of observation. Each MASCARA station consists of five low-noise off-the-shelf full-frame CCD cameras, fitted with standard Canon 24 mm , f/1.4 lenses, monitoring the near-entire sky down to magnitude 8 at that location. Measurements have demonstrated that the required Signal-to-Noise Ratio of 100, can be achieved in less than thirty minutes. MASCARA aims at deploying several stations world-wide to provide a nearly continuous coverage of the dark sky, at sub-minute cadence. While at the faint end MASCARA is limited mainly by photon noise, at the bright end scintillation and red noise become the limiting factors. Instrumental noise sources are reduced by placing the cameras in a fixed orientation and in a temperature controlled environment. By defocusing and allowing stars to drift over the detector, the impact of pixel-to-pixel variations on the photometry are minimized, while taking exposures at fixed sidereal times allows accurate cross-calibration of consecutive nights. The exposure time of 6.4 seconds gives rise to a high data acquisition rate of a MASCARA station, around 500GB per night. In order to minimize data transport and data storage requirements, the raw images are reduced to produce accurate light curves in nearly real time. The first MASCARA station will be integrated on La Palma during the summer of 2014

  15. Multi-Site Fatigue Testing and Characterization of Fuselage Panels from Aging Aircraft Structure

    DTIC Science & Technology

    2013-06-07

    Multi-site fatigue damage is a common problem in the riveted lap joint structure of aging aircraft. Modeling and characterization of such damage is...an especially daunting task. In this effort we present the results from fatigue tests which were performed on fuselage lap joints extracted from...in the lap joint . Some spot welded lap joint panels were also tested during the larger program; however, only the results from mechanically fastened

  16. Multisite organic-inorganic hybrid catalysts for the direct sustainable synthesis of GABAergic drugs.

    PubMed

    Leyva-Pérez, Antonio; García-García, Pilar; Corma, Avelino

    2014-08-11

    Multisite organic-inorganic hybrid catalysts have been prepared and applied in a new general, practical, and sustainable synthetic procedure toward industrially relevant GABA derivatives. The domino sequence is composed of seven chemical transformations which are performed in two one-pot reactions. The method produces both enantiomeric forms of the product in high enantiopurity as well as the racemate in good yields after a single column purification step. This protocol highlights major process intensification, catalyst recyclability, and low waste generation.

  17. Fundamental spectroscopic studies of carbenes and hydrocarbon radicals

    SciTech Connect

    Gottlieb, C.A.; Thaddeus, P.

    1993-12-01

    Highly reactive carbenes and carbon-chain radicals are studied at millimeter wavelengths by observing their rotational spectra. The purpose is to provide definitive spectroscopic identification, accurate spectroscopic constants in the lowest vibrational states, and reliable structures of the key intermediates in reactions leading to aromatic hydrocarbons and soot particles in combustion.

  18. Spectroscopic constants and potential energy curves of AsF

    NASA Astrophysics Data System (ADS)

    Latifzadeh, Lida; Balasubramanian, K.

    1996-02-01

    Spectroscopic constants and potential energy curves of 21 electronic states of AsF are computed using the complete active space self-consistent field (CASSCF) followed by first- and second-order configuration interaction (FOCI, SOCI) and multireference singles and doubles configuration interaction (MRSDCI) methods. The computed spectroscopic constants agree with the experimental values for the observed states.

  19. Progress in centralised ethics review processes: Implications for multi-site health evaluations.

    PubMed

    Prosser, Brenton; Davey, Rachel; Gibson, Diane

    2015-04-01

    Increasingly, public sector programmes respond to complex social problems that intersect specific fields and individual disciplines. Such responses result in multi-site initiatives that can span nations, jurisdictions, sectors and organisations. The rigorous evaluation of public sector programmes is now a baseline expectation. For evaluations of large and complex multi-site programme initiatives, the processes of ethics review can present a significant challenge. However in recent years, there have been new developments in centralised ethics review processes in many nations. This paper provides the case study of an evaluation of a national, inter-jurisdictional, cross-sector, aged care health initiative and its encounters with Australian centralised ethics review processes. Specifically, the paper considers progress against the key themes of a previous five-year, five nation study (Fitzgerald and Phillips, 2006), which found that centralised ethics review processes would save time, money and effort, as well as contribute to more equitable workloads for researchers and evaluators. The paper concludes with insights for those charged with refining centralised ethics review processes, as well as recommendations for future evaluators of complex multi-site programme initiatives.

  20. The unique character of involvement in multi-site evaluation settings.

    PubMed

    Toal, Stacie A; King, Jean A; Johnson, Kelli; Lawrenz, Frances

    2009-05-01

    As the number of large federal programs increases, so, too, does the need for a more complete understanding of how to conduct evaluations of such complex programs. The research literature has documented the benefits of stakeholder participation in smaller-scale program evaluations. However, given the scope and diversity of projects in multi-site program evaluations, traditional notions of participatory evaluation do not apply. The purpose of this research is to determine the ways in which stakeholders are involved in large-scale, multi-site STEM evaluations. This article describes the findings from a survey of 313 program leaders and evaluators and from follow-up interviews with 12 of these individuals. Findings from this study indicate that attendance at meetings and conferences, planning discussions within the project related to use of the program evaluation, and participation in data collection should be added to the list of activities that foster feelings of evaluation involvement among stakeholders. In addition, perceptions of involvement may vary according to breadth or depth of evaluation activities, but not always both. Overall, this study suggests that despite the contextual challenges of large, multi-site evaluations, it is feasible to build feelings of involvement among stakeholders.

  1. MultiSite Gateway-Compatible Cell Type-Specific Gene-Inducible System for Plants1[OPEN

    PubMed Central

    Siligato, Riccardo; Wang, Xin; Yadav, Shri Ram; Lehesranta, Satu; Ma, Guojie; Ursache, Robertas; Sevilem, Iris; Zhang, Jing; Gorte, Maartje; Prasad, Kalika; Heidstra, Renze

    2016-01-01

    A powerful method to study gene function is expression or overexpression in an inducible, cell type-specific system followed by observation of consequent phenotypic changes and visualization of linked reporters in the target tissue. Multiple inducible gene overexpression systems have been developed for plants, but very few of these combine plant selection markers, control of expression domains, access to multiple promoters and protein fusion reporters, chemical induction, and high-throughput cloning capabilities. Here, we introduce a MultiSite Gateway-compatible inducible system for Arabidopsis (Arabidopsis thaliana) plants that provides the capability to generate such constructs in a single cloning step. The system is based on the tightly controlled, estrogen-inducible XVE system. We demonstrate that the transformants generated with this system exhibit the expected cell type-specific expression, similar to what is observed with constitutively expressed native promoters. With this new system, cloning of inducible constructs is no longer limited to a few special cases but can be used as a standard approach when gene function is studied. In addition, we present a set of entry clones consisting of histochemical and fluorescent reporter variants designed for gene and promoter expression studies. PMID:26644504

  2. Multisite HPV16/18 Vaccine Efficacy Against Cervical, Anal, and Oral HPV Infection

    PubMed Central

    Kreimer, Aimée R.; Schiffman, Mark; Herrero, Rolando; Wacholder, Sholom; Rodriguez, Ana Cecilia; Lowy, Douglas R.; Porras, Carolina; Schiller, John T.; Quint, Wim; Jimenez, Silvia; Safaeian, Mahboobeh; Struijk, Linda; Schussler, John; Hildesheim, Allan; Gonzalez, Paula

    2016-01-01

    Background: Previous Costa Rica Vaccine Trial (CVT) reports separately demonstrated vaccine efficacy against HPV16 and HPV18 (HPV16/18) infections at the cervical, anal, and oral regions; however, the combined overall multisite efficacy (protection at all three sites) and vaccine efficacy among women infected with HPV16 or HPV18 prior to vaccination are less known. Methods: Women age 18 to 25 years from the CVT were randomly assigned to the HPV16/18 vaccine (Cervarix) or a hepatitis A vaccine. Cervical, oral, and anal specimens were collected at the four-year follow-up visit from 4186 women. Multisite and single-site vaccine efficacies (VEs) and 95% confidence intervals (CIs) were computed for one-time detection of point prevalent HPV16/18 in the cervical, anal, and oral regions four years after vaccination. All statistical tests were two-sided. Results: The multisite woman-level vaccine efficacy was highest among “naïve” women (HPV16/18 seronegative and cervical HPV high-risk DNA negative at vaccination) (vaccine efficacy = 83.5%, 95% CI = 72.1% to 90.8%). Multisite woman-level vaccine efficacy was also demonstrated among women with evidence of a pre-enrollment HPV16 or HPV18 infection (seropositive for HPV16 and/or HPV18 but cervical HPV16/18 DNA negative at vaccination) (vaccine efficacy = 57.8%, 95% CI = 34.4% to 73.4%), but not in those with cervical HPV16 and/or HPV18 DNA at vaccination (anal/oral HPV16/18 VE = 25.3%, 95% CI = -40.4% to 61.1%). Concordant HPV16/18 infections at two or three sites were also less common in HPV16/18-infected women in the HPV vaccine vs control arm (7.4% vs 30.4%, P < .001). Conclusions: This study found high multisite vaccine efficacy among “naïve” women and also suggests the vaccine may provide protection against HPV16/18 infections at one or more anatomic sites among some women infected with these types prior to HPV16/18 vaccination. PMID:26467666

  3. Spectroscopic mode identification in gamma Doradus stars

    NASA Astrophysics Data System (ADS)

    Rylvia Pollard, Karen

    2015-08-01

    The MUSICIAN programme at the University of Canterbury has been successfully identifying frequencies and pulsation modes in many gamma Doradus stars using hundreds of precise, high resolution spectroscopic observations. This paper describes some of these frequency and mode identifications and the emerging patterns of the programme.

  4. Development of a THz spectroscopic imaging system.

    PubMed

    Usami, M; Iwamoto, T; Fukasawa, R; Tani, M; Watanabe, M; Sakai, K

    2002-11-07

    We have developed a real-time THz imaging system based on the two-dimensional (2D) electro-optic (EO) sampling technique. Employing the 2D EO-sampling technique, we can obtain THz images using a CCD camera at a video rate of up to 30 frames per second. A spatial resolution of 1.4 mm was achieved. This resolution was reasonably close to the theoretical limit determined by diffraction. We observed not only static objects but also moving ones. To acquire spectroscopic information, time-domain images were collected. By processing these images on a computer, we can obtain spectroscopic images. Spectroscopy for silicon wafers was demonstrated.

  5. Process evaluation in a multisite, primary obesity-prevention trial in American Indian schoolchildren1–3

    PubMed Central

    Helitzer, Deborah L; Davis, Sally M; Gittelsohn, Joel; Going, Scott B; Murray, David M; Snyder, Patricia; Steckler, Allan B

    2016-01-01

    We describe the development, implementation, and use of the process evaluation component of a multisite, primary obesity prevention trial for American Indian schoolchildren. We describe the development and pilot testing of the instruments, provide some examples of the criteria for instrument selection, and provide examples of how process evaluation results were used to document and refine intervention components. The theoretical and applied framework of the process evaluation was based on diffusion theory, social learning theory, and the desire for triangulation of multiple modes of data collection. The primary objectives of the process evaluation were to systematically document the training process, content, and implementation of 4 components of the intervention. The process evaluation was developed and implemented collaboratively so that it met the needs of both the evaluators and those who would be implementing the intervention components. Process evaluation results revealed that observation and structured interviews provided the most informative data; however, these methods were the most expensive and time consuming and required the highest level of skill to undertake. Although the literature is full of idealism regarding the uses of process evaluation for formative and summative purposes, in reality, many persons are sensitive to having their work evaluated in such an in-depth, context-based manner as is described. For this reason, use of structured, quantitative, highly objective tools may be more effective than qualitative methods, which appear to be more dependent on the skills and biases of the researcher and the context in which they are used. PMID:10195608

  6. Validation of Mismatch Negativity and P3a for Use in Multi-Site Studies of Schizophrenia: Characterization of Demographic, Clinical, Cognitive, and Functional Correlates in COGS-2

    PubMed Central

    Light, Gregory A.; Swerdlow, Neal R.; Thomas, Michael L.; Calkins, Monica E.; Green, Michael F.; Greenwood, Tiffany A.; Gur, Raquel E.; Gur, Ruben C.; Lazzeroni, Laura C.; Nuechterlein, Keith H.; Pela, Marlena; Radant, Allen D.; Seidman, Larry J.; Sharp, Richard F.; Siever, Larry J.; Silverman, Jeremy M.; Sprock, Joyce; Stone, William S.; Sugar, Catherine A.; Tsuang, Debby W.; Tsuang, Ming T.; Braff, David L.; Turetsky, Bruce I.

    2014-01-01

    Mismatch negativity (MMN) and P3a are auditory event-related potential (ERP) components that show robust deficits in schizophrenia (SZ) patients and exhibit qualities of endophenotypes, including substantial heritability, test-retest reliability, and trait-like stability. These measures also fulfill criteria for use as cognition and function-linked biomarkers in outcome studies, but have not yet been validated for use in large-scale multi-site clinical studies. This study tested the feasibility of adding MMN and P3a to the ongoing Consortium on the Genetics of Schizophrenia (COGS) study. The extent to which demographic, clinical, cognitive, and functional characteristics contribute to variability in MMN and P3a amplitudes was also examined. Participants (HCS n=824, SZ n=966) underwent testing at 5 geographically distributed COGS laboratories. Valid ERP data was obtained from 91% of HCS and 91% of SZ patients. Highly significant MMN (d=0.96) and P3a (d=0.93) amplitude reductions were observed in SZ patients, comparable in magnitude to those observed in single-lab studies with no appreciable differences across laboratories. Demographic characteristics accounted for 26% and 18% of the variance in MMN and P3a amplitudes, respectively. Significant relationships were observed among demographically-adjusted MMN and P3a measures and medication status as well as several clinical, cognitive, and functional characteristics of the SZ patients. This study demonstrates that MMN and P3a ERP biomarkers can be feasibly used in multi-site clinical studies. As with many clinical tests of brain function, demographic factors contribute to MMN and P3a amplitudes and should be carefully considered in future biomarker-informed clinical studies. PMID:25449710

  7. The pulsating hot subdwarf Balloon 090100001: results of the 2005 multisite campaign

    NASA Astrophysics Data System (ADS)

    Baran, A.; Oreiro, R.; Pigulski, A.; Pérez Hernández, F.; Ulla, A.; Reed, M. D.; Rodríguez-López, C.; Moskalik, P.; Kim, S.-L.; Chen, W.-P.; Crowe, R.; Siwak, M.; Armendarez, L.; Binder, P. M.; Choo, K.-J.; Dye, A.; Eggen, J. R.; Garrido, R.; González Pérez, J. M.; Harms, S. L.; Huang, F.-Y.; Kozieł, D.; Lee, H.-T.; MacDonald, J.; Fox Machado, L.; Monserrat, T.; Stevick, J.; Stewart, S.; Terry, D.; Zhou, A.-Y.; Zoła, S.

    2009-01-01

    We present the results of a multisite photometric campaign on the pulsating B-type hot subdwarf star Balloon090100001 (Bal09). The star is one of the two known hybrid hot subdwarfs with both long- and short-period oscillations, theoretically attributed to g and p modes. The campaign involved eight telescopes with three obtaining UBVR data, four B-band data and one Strömgren uvby photometry. The campaign covered 48 nights, providing a temporal resolution of 0.36μHz with a detection threshold of about 0.2mmag in B-filter data. Bal09 has the richest pulsation spectrum of any known pulsating subdwarf B star, and our analysis detected 114 frequencies including 97 independent and 17 combination ones. Most of the 24 g-mode frequencies are between 0.1 and 0.4mHz. Of the remaining 73, presumably p modes, 72 group into four distinct regions near 2.8, 3.8, 4.7 and 5.5mHz. The density of frequencies requires that some modes must have degrees l larger than 2. The modes in the 2.8 mHz region have the largest amplitudes. The strongest mode (f1) is most likely radial, while the remaining ones in this region form two nearly symmetric multiplets: a triplet and quintuplet, attributed to rotationally split l = 1 and 2 modes, respectively. We find clear increases of splitting in both multiplets between the 2004 and 2005 observing campaigns, amounting to ~15 per cent on average. The observed splittings imply that the rotational rate in Bal09 depends on stellar latitude and is the fastest on the equator. We also speculate on the possible reasons for the changes of splitting. The only plausible explanation we find is torsional oscillation. This hypothesis, however, needs to be verified in the future by detailed modelling. In this context, it is very important to monitor the splittings on a longer time-scale as their behaviour may help to explain this interesting phenomenon. The amplitudes of almost all terms detected in both 2004 and 2005 were found to vary. This is evident even during

  8. Spectroscopic Low Coherence Interferometry

    NASA Astrophysics Data System (ADS)

    Bosschaart, Nienke; van Leeuwen, T. G.; Aalders, Maurice C.; Hermann, Boris; Drexler, Wolfgang; Faber, Dirk J.

    Low-coherence interferometry (LCI) allows high-resolution volumetric imaging of tissue morphology and provides localized optical properties that can be related to the physiological status of tissue. This chapter discusses the combination of spatial and spectroscopic information by means of spectroscopic OCT (sOCT) and low-coherence spectroscopy (LCS). We describe the theory behind these modalities for the assessment of spatially resolved optical absorption and (back)scattering coefficient spectra. These spectra can be used for the highly localized quantification of chromophore concentrations and assessment of tissue organization on (sub)cellular scales. This leads to a wealth of potential clinical applications, ranging from neonatology for the determination of billibrubin concentrations, to oncology for the optical assessment of the aggressiveness of a cancerous lesion.

  9. Exploring the Feasibility of Multi-Site Flow Cytometric Processing of Gut Associated Lymphoid Tissue with Centralized Data Analysis for Multi-Site Clinical Trials

    PubMed Central

    McGowan, Ian; Anton, Peter A.; Elliott, Julie; Cranston, Ross D.; Duffill, Kathryn; Althouse, Andrew D.; Hawkins, Kevin L.; De Rosa, Stephen C.

    2015-01-01

    The purpose of this study was to determine whether the development of a standardized approach to the collection of intestinal tissue from healthy volunteers, isolation of gut associated lymphoid tissue mucosal mononuclear cells (MMC), and characterization of mucosal T cell phenotypes by flow cytometry was sufficient to minimize differences in the normative ranges of flow parameters generated at two trial sites. Forty healthy male study participants were enrolled in Pittsburgh and Los Angeles. MMC were isolated from rectal biopsies using the same biopsy acquisition and enzymatic digestion protocols. As an additional comparator, peripheral blood mononuclear cells (PBMC) were collected from the study participants. For quality control, cryopreserved PBMC from a single donor were supplied to both sites from a central repository (qPBMC). Using a jointly optimized standard operating procedure, cells were isolated from tissue and blood and stained with monoclonal antibodies targeted to T cell phenotypic markers. Site-specific flow data were analyzed by an independent center which analyzed all data from both sites. Ranges for frequencies for overall CD4+ and CD8+ T cells, derived from the qPBMC samples, were equivalent at both UCLA and MWRI. However, there were significant differences across sites for the majority of T cell activation and memory subsets in qPBMC as well as PBMC and MMC. Standardized protocols to collect, stain, and analyze MMC and PBMC, including centralized analysis, can reduce but not exclude variability in reporting flow data within multi-site studies. Based on these data, centralized processing, flow cytometry, and analysis of samples may provide more robust data across multi-site studies. Centralized processing requires either shipping of fresh samples or cryopreservation and the decision to perform centralized versus site processing needs to take into account the drawbacks and restrictions associated with each method. PMID:26010577

  10. Replication and Comparison of the Newly Proposed ADOS-2, Module 4 Algorithm in ASD without ID: A Multi-site Study

    PubMed Central

    Pugliese, Cara E.; Kenworthy, Lauren; Bal, Vanessa Hus; Wallace, Gregory L; Yerys, Benjamin E; Maddox, Brenna B.; White, Susan W.; Popal, Haroon; Armour, Anna Chelsea; Miller, Judith; Herrington, John D.; Schultz, Robert T.; Martin, Alex; Anthony, Laura Gutermuth

    2015-01-01

    Recent updates have been proposed to the Autism Diagnostic Observation Schedule-2 Module 4 diagnostic algorithm. This new algorithm, however, has not yet been validated in an independent sample without intellectual disability (ID). This multi-site study compared the original and revised algorithms in individuals with ASD without ID. The revised algorithm demonstrated increased sensitivity, but lower specificity in the overall sample. Estimates were highest for females, individuals with a verbal IQ below 85 or above 115, and ages 16 and older. Best practice diagnostic procedures should include the Module 4 in conjunction with other assessment tools. Balancing needs for sensitivity and specificity depending on the purpose of assessment (e.g., clinical vs. research) and demographic characteristics mentioned above will enhance its utility. PMID:26385796

  11. A Hybrid Approach for Precipitation Simulation Using the Multi-site Neyman-Scott Rainfall Pulse Model and the Analog Method

    NASA Astrophysics Data System (ADS)

    Kaheil, Y. H.; Lohmann, D.; Goteti, G.; Katz, B. G.; RMS Model Dev Team

    2011-12-01

    The Multi-site Neyman-Scott Rainfall Pulse model (MNSRP) was previously implemented in many studies over different climate zones and is known for its capability to accurately capture the statistical and the geostatistical properties of the precipitation process up to the third moment, which is a key factor in extreme precipitation analysis. However, due to the purely stochastic nature of the model, larger spatial precipitation patterns cannot be captured, especially when the model is implemented over large regions. The Analog Method (AM) uses observed precipitation EOFs to accurately simulate precipitation spatially. The quality of the AM simulations suffers in arid and semi-arid regions where the statistical properties of the precipitation process are harder to capture. The Hybrid Approach (HA) uses the AM simulations to locally rank the MNSRP simulations for each month. Case studies in different climatic regions in the US show that the new approach compares favorably to each individual model.

  12. Multivariate real-time assessment of droughts via copula-based multi-site Hazard Trajectories and Fans

    NASA Astrophysics Data System (ADS)

    Salvadori, G.; De Michele, C.

    2015-07-01

    Droughts, like floods, represent the most dangerous, and costly, water cycle expressions, with huge impacts on society and built environment. Droughts are events occurring over a certain region, lasting several weeks or months, and involving multiple variables: thus, a multivariate, multi-site, approach is most appropriate for their statistical characterization. In this methodological work, hydrological droughts are considered, and a multivariate approach is proposed, by regarding as relevant variables the duration and the average intensity. A multivariate, multi-site, frequency analysis is presented, based on the Theory of Copulas and the joint Survival Kendall's Return Periods, by investigating the historical drought episodes occurred at five main river sections of the Po river (Northern Italy), the most important Italian basin. The tool of Dynamic Return Period is used, and the new concepts of Hazard Trajectories and Fans are introduced, in order to provide useful indications for a valuable multi-site real-time assessment of droughts.

  13. Spectroscopic madness - A golden age for amateurs

    NASA Astrophysics Data System (ADS)

    Eversberg, Thomas

    2011-01-01

    Today, professional instrumentation is dominated by heavily oversubscribed telescopes which focus mainly on a limited number of ``fashionable'' research topics. As a result, time acquisition for massive star research including extended observation campaigns, becomes more difficult. On the other hand, massive star investigations by amateur astronomers performing spectroscopic measurements are on a level which can fulfil professional needs. I describe the instrumentation available to the amateurs, their observational skills and the potential contribution they can make to the professional community.

  14. Approaches and Recommendations for Simulating Extreme Precipitation Years in Multi-site Experiments

    NASA Astrophysics Data System (ADS)

    Knapp, A.; Collins, S. L.; Dukes, J.; Loik, M. E.; Phillips, R.; Sala, O. E.; Smith, M.

    2015-12-01

    Worldwide, human activities are exposing all ecosystems to increases in atmospheric CO2, N and temperature. Precipitation also is being altered globally, but increases in precipitation variability and extremes are expected to have greater impacts on ecosystem function than changes in means. Determining how and why ecosystems differ in their sensitivity to precipitation extremes (i.e., drought) is key to forecasting future ecosystem structure and function at the global scale. Coordinated multi-site experiments can be invaluable for assessing differential sensitivity of ecosystems (deserts, grasslands, forests, etc.) to precipitation extremes. However, determining treatment levels in these experiments presents unique problems because extremes in precipitation are defined statistically, based on historical context, and thus can differ dramatically among sites. Therefore, while multi-site experiments with fixed treatment levels may be appropriate for assessing ecosystem sensitivity to CO2 or warming, they may provide less mechanistic insight for studying extremes. We propose that for multi-site experiments focused on variability and extremes, the amount of precipitation removed or added to impose precipitation extremes should be site-specific (not fixed across sites) and matched to the historical climate record. Further, because extreme wet and dry years differ from each other in other attributes (event size, number of events, consecutive dry days, etc.) treatments should incorporate realistic alterations in these precipitation attributes as well. We show that for most ecosystem types globally, experimental infrastructure that passively reduces each rainfall event can realistically simulate drought, with the addition of a few large precipitation events realistically simulating extreme wet years. Thus, while treatment levels required to impose extreme precipitation years should vary among ecosystems, alterations in precipitation attributes can be imposed uniformly.

  15. Reliability of an fMRI Paradigm for Emotional Processing in a Multisite Longitudinal Study

    PubMed Central

    Gee, Dylan G.; McEwen, Sarah C.; Forsyth, Jennifer K.; Haut, Kristen M.; Bearden, Carrie E.; Addington, Jean; Goodyear, Bradley; Cadenhead, Kristin S.; Mirzakhanian, Heline; Cornblatt, Barbara A.; Olvet, Doreen; Mathalon, Daniel H.; McGlashan, Thomas H.; Perkins, Diana O.; Belger, Aysenil; Seidman, Larry J.; Thermenos, Heidi; Tsuang, Ming T.; van Erp, Theo G.M.; Walker, Elaine F.; Hamann, Stephan; Woods, Scott W.; Constable, Todd; Cannon, Tyrone D.

    2015-01-01

    Multisite neuroimaging studies can facilitate the investigation of brain-related changes in many contexts, including patient groups that are relatively rare in the general population. Though multisite studies have characterized the reliability of brain activation during working memory and motor functional magnetic resonance imaging tasks, emotion processing tasks, pertinent to many clinical populations, remain less explored. A traveling participants study was conducted with eight healthy volunteers scanned twice on consecutive days at each of the eight North American Longitudinal Prodrome Study sites. Tests derived from generalizability theory showed excellent reliability in the amygdala (Eρ2=0.82), inferior frontal gyrus (IFG;Eρ2=0.83), anterior cingulate cortex (ACC;Eρ2=0.76), insula (Eρ2=0.85), and fusiform gyrus (Eρ2=0.91) for maximum activation and fair to excellent reliability in the amygdala (Eρ2=0.44), IFG (Eρ2=0.48), ACC (Eρ2=0.55), insula (Eρ2=0.42), and fusiform gyrus (Eρ2=0.83) for mean activation across sites and test days. For the amygdala, habituation (Eρ2=0.71) was more stable than mean activation. In a second investigation, data from 111 healthy individuals across sites were aggregated in a voxelwise, quantitative meta-analysis. When compared with a mixed effects model controlling for site, both approaches identified robust activation in regions consistent with expected results based on prior single-site research. Overall, regions central to emotion processing showed strong reliability in the traveling participants study and robust activation in the aggregation study. These results support the reliability of blood oxygen level-dependent signal in emotion processing areas across different sites and scanners and may inform future efforts to increase efficiency and enhance knowledge of rare conditions in the population through multisite neuroimaging paradigms. PMID:25821147

  16. A Bayesian hierarchical nonhomogeneous hidden Markov model for multisite streamflow reconstructions

    NASA Astrophysics Data System (ADS)

    Bracken, C.; Rajagopalan, B.; Woodhouse, C.

    2016-10-01

    In many complex water supply systems, the next generation of water resources planning models will require simultaneous probabilistic streamflow inputs at multiple locations on an interconnected network. To make use of the valuable multicentury records provided by tree-ring data, reconstruction models must be able to produce appropriate multisite inputs. Existing streamflow reconstruction models typically focus on one site at a time, not addressing intersite dependencies and potentially misrepresenting uncertainty. To this end, we develop a model for multisite streamflow reconstruction with the ability to capture intersite correlations. The proposed model is a hierarchical Bayesian nonhomogeneous hidden Markov model (NHMM). A NHMM is fit to contemporary streamflow at each location using lognormal component distributions. Leading principal components of tree rings are used as covariates to model nonstationary transition probabilities and the parameters of the lognormal component distributions. Spatial dependence between sites is captured with a Gaussian elliptical copula. Parameters of the model are estimated in a fully Bayesian framework, in that marginal posterior distributions of all the parameters are obtained. The model is applied to reconstruct flows at 20 sites in the Upper Colorado River Basin (UCRB) from 1473 to 1906. Many previous reconstructions are available for this basin, making it ideal for testing this new method. The results show some improvements over regression-based methods in terms of validation statistics. Key advantages of the Bayesian NHMM over traditional approaches are a dynamic representation of uncertainty and the ability to make long multisite simulations that capture at-site statistics and spatial correlations between sites.

  17. Predictive risk factors for chronic regional and multisite musculoskeletal pain: a 5-year prospective study in a working population.

    PubMed

    Herin, Fabrice; Vézina, Michel; Thaon, Isabelle; Soulat, Jean-Marc; Paris, Christophe

    2014-05-01

    The role of psychosocial and physical factors in the development of musculoskeletal pain (MSP) has now been clearly demonstrated. However, it is unclear whether these factors contribute to specific regional MSP or to multisite pain. The main goal of this study was to assess the impact of work-related factors according to gender on the development of regional and multisite MSP. A total of 12,591 subjects (65% men and 35% women) who were born in 1938, 1943, 1948, and 1953 and were participating in a French longitudinal prospective epidemiological survey (ESTEV) in 1990 to 1995 were eligible. Personal factors and work exposure were assessed by self-administered questionnaires. Statistical associations between chronic MSP (regional body site or multisite), personal factors, and occupational factors were analyzed using logistic regression modeling. The incidence of regional MSP and multisite pain in 1995 were, respectively, 17% and 25.6%. For women, highly repetitive movements predicted neck/shoulder pain; posture and vibrations predicted arm and low back pain; and effort with tools predicted arm pain. For men, forceful effort and vibrations predicted neck/shoulder pain; posture and forceful effort predicted lower limb and low back pain; and forceful effort and effort with tools predicted arm pain. Physical constraints (ie, forceful effort or vibrations) were associated with multisite pain in both genders. Only for women, psychological factors were risk factors predictive of upper limb pain and in 3 or 4 painful anatomical sites. These results support the hypothesis that some physical and psychological work-related factors are predictive of regional or multisite MSP but differ according to gender. Gender differences and risk factors for work-related musculoskeletal pain should be also taken into account to more effectively target preventive measures.

  18. The 2003-2004 multisite photometric campaign for the β Cephei and eclipsing star 16 (EN) Lacertae with an appendix on 2 Andromedae, the variable comparison star

    NASA Astrophysics Data System (ADS)

    Jerzykiewicz, M.; Handler, G.; Daszyńska-Daszkiewicz, J.; Pigulski, A.; Poretti, E.; Rodríguez, E.; Amado, P. J.; Kołaczkowski, Z.; Uytterhoeven, K.; Dorokhova, T. N.; Dorokhov, N. I.; Lorenz, D.; Zsuffa, D.; Kim, S.-L.; Bourge, P.-O.; Acke, B.; De Ridder, J.; Verhoelst, T.; Drummond, R.; Movchan, A. I.; Lee, J.-A.; Stȩślicki, M.; Molenda-Żakowicz, J.; Garrido, R.; Kim, S.-H.; Michalska, G.; Paparó, M.; Antoci, V.; Aerts, C.

    2015-11-01

    A multisite photometric campaign for the β Cephei and eclipsing variable 16 Lacertae is reported. 749 h of high-quality differential photoelectric Strömgren, Johnson and Geneva time series photometry were obtained with 10 telescopes during 185 nights. After removing the pulsation contribution, an attempt was made to solve the resulting eclipse light curve by means of the computer program EBOP. Although a unique solution was not obtained, the range of solutions could be constrained by comparing computed positions of the secondary component in the Hertzsprung-Russell diagram with evolutionary tracks. For three high-amplitude pulsation modes, the uvy and the Geneva UBG amplitude ratios are derived and compared with the theoretical ones for spherical-harmonic degrees ℓ ≤ 4. The highest degree, ℓ = 4, is shown to be incompatible with the observations. One mode is found to be radial, one is ℓ = 1, while in the remaining case ℓ = 2 or 3. The present multisite observations are combined with the archival photometry in order to investigate the long-term variation of the amplitudes and phases of the three high-amplitude pulsation modes. The radial mode shows a non-sinusoidal variation on a time-scale of 73 yr. The ℓ = 1 mode is a triplet with unequal frequency spacing, giving rise to two beat-periods, 720.7 d and 29.1 yr. The amplitude and phase of the ℓ = 2 or 3 mode vary on time-scales of 380.5 d and 43 yr. The light variation of 2 And, one of the comparison stars, is discussed in the appendix.

  19. Spectroscopic constants and potential energy curves of GeF +

    NASA Astrophysics Data System (ADS)

    Xu, Hua; Balasubramanian, K.

    1995-05-01

    Spectroscopic constants and potential energy curves of 27 electronic states of GeF + are computed using the complete active space self-consistent field (CASSCF) followed by first- and second-order configuration interaction (FOCI, SOCI) methods that included up to 1.6 million configurations. Our computed spectroscopic constants of the 1Σ+ electronic state fit well with the experimentally observed X ground state. Other yet to be observed properties of several excited electronic states are reported.

  20. Spectroscopic constants and potential energy curves of SnF

    NASA Astrophysics Data System (ADS)

    Dai, Dingguo; Balasubramanian, K.

    1994-07-01

    Spectroscopic constants and potential energy curves of 20 electronic states of SnF arising from valence dissociation limits are computed using the complete active space MCSCF (CASSCF) followed by first- and second-order configuration interaction (FOCI, SOCI) methods, which included up to one million configurations. Our computed spectroscopic constants of five electronic states fit well with the experimentally observed X, A, a, and C states. The dipole moments and other yet to be observed properties of several electronic states are reported.

  1. The Benefits and Challenges of Preconsent in a Multisite, Pediatric Sickle Cell Intervention Trial.

    PubMed

    Nimmer, Mark; Czachor, Jason; Turner, Laura; Thomas, Bobbe; Woodford, Ashley L; Carpenter, Karli; Gonzalez, Victor; Liem, Robert I; Ellison, Angela; Casper, T Charles; Brousseau, David C

    2016-09-01

    Enrollment of patients in sickle cell intervention trials has been challenging due to difficulty in obtaining consent from a legal guardian and lack of collaboration between emergency medicine and hematology. We utilized education and preconsent in a pediatric multisite sickle cell intervention trial to overcome these challenges. Overall, 48 patients were enrolled after being preconsented. Variable Institutional Review Board policies related to preconsent validity and its allowable duration decreased the advantages of preconsent at some sites. The utility of preconsent for future intervention trials largely depends on local Institutional Review Board policies. Preeducation may also benefit the consent process, regardless of site differences.

  2. Congenital Anomalies in Contaminated Sites: A Multisite Study in Italy

    PubMed Central

    Santoro, Michele; Minichilli, Fabrizio; Pierini, Anna; Astolfi, Gianni; Bisceglia, Lucia; Carbone, Pietro; Conti, Susanna; Dardanoni, Gabriella; Iavarone, Ivano; Ricci, Paolo; Scarano, Gioacchino; Bianchi, Fabrizio

    2017-01-01

    The health impact on populations residing in industrially contaminated sites (CSs) is recognized as a public health concern especially in relation to more vulnerable population subgroups. The aim of this study was to estimate the risk of congenital anomalies (CAs) in Italian CSs. Thirteen CSs covered by regional CA registries were investigated in an ecological study. The observed/expected ratios (O/E) with 90% confidence intervals (CI) for the total and specific subgroups of CAs were calculated using the regional areas as references. For the CSs with waste landfills, petrochemicals, and refineries, pooled estimates were calculated. The total number of observed cases of CAs was 7085 out of 288,184 births (prevalence 245.8 per 10,000). For some CSs, excesses for several CA subgroups were observed, in particular for genital and heart defects. The excess of genital CAs observed in Gela (O/E 2.36; 90% CI 1.73–3.15) is consistent with findings from other studies. For CSs including petrochemical and landfills, the pooled risk estimates were 1.10 (90% CI 1.01–1.19) and 1.07 (90% CI 1.02–1.13), respectively. The results are useful in identifying priority areas for analytical investigations and in supporting the promotion of policies for the primary prevention of CAs. The use of short-latency effect indicators is recommended for the health surveillance of the populations residing in CSs. PMID:28287452

  3. Mauna Kea Observatory infrared observations

    NASA Technical Reports Server (NTRS)

    Jefferies, J. T.

    1974-01-01

    Galactic and solar system infrared observations are reported using a broad variety of radiometric and spectroscopic instrumentation. Infrared programs and papers published during this period are listed.

  4. On the use of multi-algorithm, genetically adaptive multi-objective method for multi-site calibration of the SWAT model

    SciTech Connect

    Zhang, Xuesong; Srinivasan, Raghavan; Van Liew, M.

    2010-04-15

    With the availability of spatially distributed data, distributed hydrologic models are increasingly used for simulation of spatially varied hydrologic processes to understand and manage natural and human activities that affect watershed systems. Multi-objective optimization methods have been applied to calibrate distributed hydrologic models using observed data from multiple sites. As the time consumed by running these complex models is increasing substantially, selecting efficient and effective multi-objective optimization algorithms is becoming a nontrivial issue. In this study, we evaluated a multi-algorithm, genetically adaptive multi-objective method (AMALGAM) for multi-site calibration of a distributed hydrologic model—Soil and Water Assessment Tool (SWAT), and compared its performance with two widely used evolutionary multi-objective optimization (EMO) algorithms (i.e. Strength Pareto Evolutionary Algorithm 2 (SPEA2) and Non-dominated Sorted Genetic Algorithm II (NSGA-II)). In order to provide insights into each method’s overall performance, these three methods were tested in four watersheds with various characteristics. The test results indicate that the AMALGAM can consistently provide competitive or superior results compared with the other two methods. The multi-method search framework of AMALGAM, which can flexibly and adaptively utilize multiple optimization algorithms, makes it a promising tool for multi-site calibration of the distributed SWAT. For practical use of AMALGAM, it is suggested to implement this method in multiple trials with relatively small number of model runs rather than run it once with long iterations. In addition, incorporating different multiobjective optimization algorithms and multi-mode search operators into AMALGAM deserves further research.

  5. Potential interoperability problems facing multi-site radiation oncology centers in The Netherlands

    NASA Astrophysics Data System (ADS)

    Scheurleer, J.; Koken, Ph; Wessel, R.

    2014-03-01

    Aim: To identify potential interoperability problems facing multi-site Radiation Oncology (RO) departments in the Netherlands and solutions for unambiguous multi-system workflows. Specific challenges confronting the RO department of VUmc (RO-VUmc), which is soon to open a satellite department, were characterized. Methods: A nationwide questionnaire survey was conducted to identify possible interoperability problems and solutions. Further detailed information was obtained by in-depth interviews at 3 Dutch RO institutes that already operate in more than one site. Results: The survey had a 100% response rate (n=21). Altogether 95 interoperability problems were described. Most reported problems were on a strategic and semantic level. The majority were DICOM(-RT) and HL7 related (n=65), primarily between treatment planning and verification systems or between departmental and hospital systems. Seven were identified as being relevant for RO-VUmc. Departments have overcome interoperability problems with their own, or with tailor-made vendor solutions. There was little knowledge about or utilization of solutions developed by Integrating the Healthcare Enterprise Radiation Oncology (IHE-RO). Conclusions: Although interoperability problems are still common, solutions have been identified. Awareness of IHE-RO needs to be raised. No major new interoperability problems are predicted as RO-VUmc develops into a multi-site department.

  6. Flexible split-ring electrode for insect flight biasing using multisite neural stimulation.

    PubMed

    Tsang, Wei Mong; Stone, Alice L; Aldworth, Zane N; Hildebrand, John G; Daniel, Tom L; Akinwande, Akintunde Ibitayo; Voldman, Joel

    2010-07-01

    We describe a flexible multisite microelectrode for insect flight biasing using neural stimulation. The electrode is made of two layers of polyimide (PI) with gold sandwiched in between in a split-ring geometry. The split-ring design in conjunction with the flexibility of the PI allows for a simple insertion process and provides good attachment between the electrode and ventral nerve cord of the insect. Stimulation sites are located at the ends of protruding tips that are circularly distributed inside the split-ring structure. These protruding tips penetrate into the connective tissue surrounding the nerve cord. We have been able to insert the electrode into pupae of the giant sphinx moth Manduca sexta as early as seven days before the adult moth emerges, and we are able to use the multisite electrode to deliver electrical stimuli that evoke multidirectional, graded abdominal motions in both pupae and adult moths. Finally, in loosely tethered flight, we have used stimulation through the flexible microelectrodes to alter the abdominal angle, thus causing the flying moth to deviate to the left or right of its intended path.

  7. A multi-site approach towards integrating environmental management in the wine production industry.

    PubMed

    Walsdorff, A; van Kraayenburg, M; Barnardt, C A

    2005-01-01

    Nine wineries and a water bottling plant situated in the Franschhoek Valley, South Africa, have decided to lead the way towards creating a safer and more sustainable environment in the Valley. As part of the Vignerons de Franschhoek ECO Association (VFEA), they adopted a multi-site approach and obtained, in December 2003, the first ISO 14001 multi-site certification in South Africa. This proactive approach allows them better overall environmental performances through mutual motivation, information sharing and comparison of practices by the different participating organisations of Franschhoek Valley. At the initiation of the project, the major concerns were associated with a lack of sound environmental management and training of employees. Of particular concern was also the lack of monitoring and measurement of environmental performance key indicators, especially in water consumption and wastewater disposal areas. Although the system is still in its juvenile stage, it already showed some effluent quality improvements through better wastewater management, better control over chemical stores as well as definite improvement in water management and increase in solid wastes recycling. The latter improvements will definitely entail long-term cost savings should the system be continually and properly maintained. It is the intention of the VFEA to create a more environmentally friendly and sustainable Valley by convincing others to be more environmentally responsive and expanding the ISO 14001 principles to other areas of the organisations including the farms, to other wineries and ultimately to the whole Franschhoek Valley.

  8. eGEMs: Pathways to Success for Multisite Clinical Data Research

    PubMed Central

    McGraw JD, Deven C.; Leiter JD, Alice B.

    2013-01-01

    There are numerous and significant challenges associated with leveraging electronic clinical data (ECD) for purposes beyond treating an individual patient and getting paid for that care. Optimizing this secondary use of clinical data is a key underpinning of many health reform goals and triggers numerous issues related to data stewardship and, more broadly, data governance. These challenges often involve legal, policy, and procedural issues related to the access, use, and disclosure of electronic health record (EHR) data for quality improvement and research. This paper contributes to the ongoing discussion of health data governance by detailing the experiences of nine multisite research initiatives across the country. The rich set of experiences from these initiatives, as well as a number of resources used by project participants to work through various challenges, are documented and collected here for others wishing to learn from their collective efforts. The paper does not attempt to catalog the full spectrum of governance issues that could potentially surface in the course of multisite research projects using ECD. Rather, the goal was to provide a snapshot in time of data-sharing challenges and navigation strategies, as well as validation that privacy-protective, legally compliant clinical data sharing across sites is currently possible. Finally, the paper also provides a foundation and framing for a broader community resource on governance—a “governance toolkit”—that will create a virtual space for the further discussion and sharing of promising practices. PMID:25848568

  9. A novel high channel-count system for acute multisite neuronal recordings.

    PubMed

    Hofmann, Ulrich G; Folkers, Andre; Mösch, Florian; Malina, Thomas; Menne, Kerstin M L; Biella, Gerardo; Fagerstedt, Patriq; De Schutter, Erik; Jensen, Winnie; Yoshida, Ken; Hoehl, Dirk; Thomas, Uwe; Kindlundh, Maria G; Norlin, Peter; de Curtis, Marco

    2006-08-01

    Multisite recording represents a suitable condition to study microphysiology and network interactions in the central nervous system and, therefore, to understand brain functions. Several different materials and array configurations have been proposed for the development of new probes utilized to record brain activity from experimental animal models. We describe new multisite silicon probes that broaden the currently available application base for neuroscientists. The array arrangement of the probes recording sites was extended to increase their spatial resolution. Probes were integrated with a newly developed electronic hardware and novel software for advanced real-time processing and analysis. The new system, based on 32- and 64-electrode silicon probes, proved very valuable to record field potentials and single unit activity from the olfactory-limbic cortex of the in vitro isolated guinea-pig brain preparation and to acutely record unit activity at multiple sites from the cerebellar cortex in vivo. The potential advantages of the new system in comparison to the currently available technology are discussed.

  10. Diffusion modifies the connectivity of kinetic schemes for multisite binding and catalysis.

    PubMed

    Gopich, Irina V; Szabo, Attila

    2013-12-03

    The simplest way to describe the influence of the relative diffusion of the reactants on the time course of bimolecular reactions is to modify or renormalize the phenomenological rate constants that enter into the rate equations of conventional chemical kinetics. However, for macromolecules with multiple inequivalent reactive sites, this is no longer sufficient, even in the low concentration limit. The physical reason is that an enzyme (or a ligand) that has just modified (or dissociated from) one site can bind to a neighboring site rather than diffuse away. This process is not described by the conventional chemical kinetics, which is only valid in the limit that diffusion is fast compared with reaction. Using an exactly solvable many-particle reaction-diffusion model, we show that the influence of diffusion on the kinetics of multisite binding and catalysis can be accounted for by not only scaling the rates, but also by introducing new connections into the kinetic scheme. The rate constants that describe these new transitions or reaction channels turn out to have a transparent physical interpretation: The chemical rates are scaled by the appropriate probabilities that a pair of reactants, which are initially in contact, bind rather than diffuse apart. The theory is illustrated by application to phosphorylation of a multisite substrate.

  11. An efficient statistical approach to multi-site downscaling of daily precipitation series in the context of climate change

    NASA Astrophysics Data System (ADS)

    Khalili, Malika; Van Nguyen, Van Thanh

    2016-11-01

    Global Climate Models (GCMs) have been extensively used in many climate change impact studies. However, the coarser resolution of these GCM outputs is not adequate to assess the potential effects of climate change on local scale. Downscaling techniques have thus been proposed to resolve this problem either by dynamical or statistical approaches. The statistical downscaling (SD) methods are widely privileged because of their simplicity of implementation and use. However, many of them ignore the observed spatial dependence between different locations, which significantly affects the impact study results. An improved multi-site SD approach is thus presented in this paper to downscaling of daily precipitation at many sites concurrently. This approach is based on a combination of multiple regression models for rainfall occurrences and amounts and the Singular Value Decomposition technique, which models the stochastic components of these regression models to preserve accurately the space-time statistical properties of the daily precipitation. Furthermore, this method was able to describe adequately the intermittency property of the precipitation processes. The proposed approach has been assessed using 10 rain gauges located in the southwest region of Quebec and southeast region of Ontario in Canada, and climate predictors from the National Centers for Environmental Prediction/National Centre for Atmospheric Research re-analysis data set. The results have indicated the ability of the proposed approach to reproduce accurately multiple observed statistical properties of the precipitation occurrences and amounts, the at-site temporal persistence, the spatial dependence between sites and the temporal variability and spatial intermittency of the precipitation processes.

  12. Progressive Reduction in Cortical Thickness as Psychosis Develops: A Multisite Longitudinal Neuroimaging Study of Youth at Elevated Clinical Risk

    PubMed Central

    Cannon, Tyrone D.; Chung, Yoonho; He, George; Sun, Daqiang; Jacobson, Aron; van Erp, Theo G. M.; McEwen, Sarah; Addington, Jean; Bearden, Carrie E.; Cadenhead, Kristin; Cornblatt, Barbara; Mathalon, Daniel H.; McGlashan, Thomas; Perkins, Diana; Jeffries, Clark; Seidman, Larry J.; Tsuang, Ming; Walker, Elaine; Woods, Scott W.; Heinssen, Robert

    2014-01-01

    Background Individuals at clinical high-risk (CHR) who progress to fully psychotic symptoms have been observed to show a steeper rate of cortical gray matter reduction compared with those without symptomatic progression and with healthy controls. Whether such changes reflect processes associated with the pathophysiology of schizophrenia or exposure to antipsychotic drugs is unknown. Methods In this multisite study, 274 CHR cases, including 35 who converted to psychosis, and 135 healthy comparison subjects were scanned with MRI at baseline, 12-month follow-up, and/or the point of conversion for those who developed fully psychotic symptoms. Results In a traveling subjects sub-study, we observed excellent reliability for measures of cortical thickness and subcortical volumes. Controlling for multiple comparisons throughout the brain, CHR converters showed a steeper rate of gray matter loss in right superior frontal, middle frontal, and medial orbitofrontal cortical regions, as well as a greater rate of expansion of the third ventricle, compared with CHR non-converters and healthy controls. Differential tissue loss was present among cases who had not received antipsychotic medications during the inter-scan interval and was predicted by baseline levels of an aggregate measure of pro-inflammatory cytokines in plasma. Conclusions These findings demonstrate that the brain changes are not explained by exposure to antipsychotic drugs, but likely play a role in psychosis pathophysiology. Given that the cortical changes were more pronounced among cases with briefer durations of prodromal symptoms, contributing factors may predominantly play a role in acute-onset forms of psychosis. PMID:25034946

  13. Gender Differences in Clinical Outcomes among HIV-Positive Individuals on Antiretroviral Therapy in Canada: A Multisite Cohort Study

    PubMed Central

    Cescon, Angela; Patterson, Sophie; Chan, Keith; Palmer, Alexis K.; Margolese, Shari; Burchell, Ann N.; Cooper, Curtis; Klein, Marina B.; Machouf, Nima; Montaner, Julio S. G.; Tsoukas, Chris; Hogg, Robert S.; Raboud, Janet M.; Loutfy, Mona R.

    2013-01-01

    Background Cohort data examining differences by gender in clinical responses to combination antiretroviral therapy (ART) remain inconsistent and have yet to be explored in a multi-province Canadian setting. This study investigates gender differences by injection drug use (IDU) history in virologic responses to ART and mortality. Methods Data from the Canadian Observational Cohort (CANOC) collaboration, a multisite cohort study of HIV-positive individuals initiating ART after January 1, 2000, were included. This analysis was restricted to participants with a follow-up HIV-RNA plasma viral load measure and known IDU history. Weibull hazard regression evaluated time to virologic suppression (2 consecutive measures <50 copies/mL), rebound (>1000 copies/mL after suppression), and all-cause mortality. Sensitivity analyses explored the impact of presumed ART use in pregnancy on virologic outcomes. Results At baseline, women (1120 of 5442 participants) were younger (median 36 vs. 41 years) and more frequently reported IDU history (43.5% vs. 28.8%) (both p<0.001). Irrespective of IDU history, in adjusted multivariable analyses women were significantly less likely to virologically suppress after ART initiation and were at increased risk of viral load rebound. In adjusted time to death analysis, no differences by gender were noted. After adjusting for presumed ART use in pregnancy, observed gender differences in time to virologic suppression for non-IDU, and time to virologic rebound for IDU, became insignificant. Conclusions HIV-positive women in CANOC are at heightened risk for poor clinical outcomes. Further understanding of the intersections between gender and other factors augmenting risk is needed to maximize the benefits of ART. PMID:24391803

  14. Spectroscopic Constants and Potential Energy Curves for GeF

    NASA Astrophysics Data System (ADS)

    Liao, D. W.; Balasubramanian, K.

    1994-01-01

    The spectroscopic constants of the electronic states of GeF lying below the 60000 cm -1 region are obtained using the complete active space multiconfiguration self-consistent field followed by first- and second-order configuration interaction (FOCI. SOCI) methods which included up to a million configurations. The potential energy curves of the low-lying electronic states are also computed. The computed spectroscopic constants confirm the assignments of the X, A, a, C, C', and D' states of GeF. In addition the spectroscopic constants of several electronic states of GeF are predicted which are yet to be observed.

  15. Spectroscopic Constants and Potential Energy Curves for GeBr

    NASA Astrophysics Data System (ADS)

    Liao, D. W.; Balasubramanian, K.

    1993-12-01

    Spectroscopic constants and potential energy curves of several low-lying electronic states of the GeBr radical are computed using the complete active space multiconfiguration self-consistent filed (CASSCF) followed by first- and second-order configuration interaction (FOCI, SOCI) methods which included up to a million configurations. Our computed spectroscopic constants confirm the assignments of X, A, A‧, B, and C states. Spectroscopic properties of several other electronic states below 30 000 cm-1 are predicted, which are yet to be observed.

  16. Spectroscopic investigation of highly transient pinch plasmas

    SciTech Connect

    Bergmann, K.; Engel, A.; Lebert, R.; Rosmej, O.N.; Rosmej, F.B.; Gavrilescu, C.; Neff, W.

    1997-11-01

    The temporal evolution of neon pinch plasmas, generated in a 2 kJ plasma focus device, has been investigated by x-ray spectroscopic methods for two sets of device parameters. These two sets lead to characteristic differences of the K-shell emission. Stationary models are shown to fail to explain the experimental observations even qualitatively. Transient spectra analysis shows that the characteristic differences observed can be referred to different transient modes of plasma dynamics. The spectra analysis includes beside resonance lines also dielectronic satellites and recombination continua. The results concerning the development of the plasma parameters achieved by the spectra modeling are supported by independent measurements of the time resolved K-shell emission and by optical streak images of the pinch plasma dynamics, which confirms the reliability of the transient spectroscopic analysis presented. {copyright} {ital 1997} {ital The American Physical Society}

  17. Spectroscopic Sensitivity Workout: First-order modes

    NASA Astrophysics Data System (ADS)

    Brown, Thomas

    2003-07-01

    We will observe the primary flux standards G191B2B, GD71 and GD153, obtaining first-order spectra in all L-modes {G191B2B only in the CCD modes due to its high brightness in the UV}. By comparing observed and model spectra, we will update calibration reference files describing spectroscopic sensitivity {and CTE loss} as a function of time. On visit of GD71 will be spent on verifying the recently derived CTE formula for STIS Spectroscopic modes with the CCD, by stepping the target along the slit {7 positions} with two {short} exposure times. This will verify the results using the two-amplifier readout method, and provide high-S/N data at low intensity levels and low background level.

  18. Multisite inhibition of Pinus pinea isocitrate lyase by phosphate.

    PubMed

    Ranaldi, F; Vanni, P; Giachetti, E

    2000-11-01

    Our results show that the phosphate ion is a nonlinear competitive inhibitor of Pinus pinea isocitrate lyase. In addition, this compound induces a sigmoidal response of the enzyme, which usually exhibits standard Michaelis-Menten kinetics. This peculiar behavior of P. pinea isocitrate lyase could be explained by a dimer (two-site) model, in which phosphate binds cooperatively, but the affinity of the vacant site for substrate (the magnesium-isocitrate complex) remains the same. As a result, the interaction of phosphate with free enzyme produces an inhibitor-enzyme-inhibitor species that is of significant importance in determining reaction rate; a possible regulatory role of the glyoxylate cycle by inorganic phosphate is suggested. The mode of phosphate inhibition is consistent with both the mechanism for magnesium ion activation of P. pinea isocitrate lyase and its site heterogeneity. Our results explain the cooperative effects observed by some authors in kinetic studies of isocitrate lyase carried out in phosphate buffers and also account for the higher K(m) values determined by using such assay systems. Phosphate buffer should be avoided in performing isocitrate lyase kinetics.

  19. Learning "about" and "from" Variation in Program Impacts Using Multisite Trials. MDRC Working Papers on Research Methodology

    ERIC Educational Resources Information Center

    Raudenbush, Stephen W.; Bloom, Howard S.

    2015-01-01

    The present paper, which is intended for a diverse audience of evaluation researchers, applied social scientists, and research funders, provides a broad overview of the conceptual and statistical issues involved in using multisite randomized trials to learn "about" and "from" variation in program effects across…

  20. Collaborative Imaginaries and Multi-Sited Ethnography: Space-Time Dimensions of Engagement in an Afterschool Science Programme for Girls

    ERIC Educational Resources Information Center

    Rahm, Jrene

    2012-01-01

    Temporal and spatial configurations that constitute learning and identity work across practices have been little explored in studies of science literacy development. Grounded in multi-sited ethnography, this paper explores diverse girls' engagement with and identity work in science locally, inside a newsletter activity in an afterschool programme…

  1. Distortions in Distributions of Impact Estimates in Multi-Site Trials: The Central Limit Theorem Is Not Your Friend

    ERIC Educational Resources Information Center

    May, Henry

    2014-01-01

    Interest in variation in program impacts--How big is it? What might explain it?--has inspired recent work on the analysis of data from multi-site experiments. One critical aspect of this problem involves the use of random or fixed effect estimates to visualize the distribution of impact estimates across a sample of sites. Unfortunately, unless the…

  2. Awareness of Diagnosis and Knowledge of HPV in Women Patients: Data from a Multi-Site Study

    ERIC Educational Resources Information Center

    McCree, Donna Hubbard; Daley, Ellen M.; Gorbach, Pamina; Hamm, Robert M.; Sharpe, Patricia A.; Brandt, Heather M.; McFarlane, Mary; Kerndt, Peter; McDermott, Robert J.; Perrin, Karen M.; St. Lawrence, Janet S.

    2010-01-01

    Background: Persistent infection with high-risk types of human papillomavirus (HPV) is associated with cervical and other anogenital cancers. Purpose: This paper reports results of awareness of an HPV diagnosis and HPV knowledge from a multi-site study of HPV knowledge, attitudes and behavior, and the impact of an HPV diagnosis on women and their…

  3. Consequences of Being Bullied: Results from a Longitudinal Assessment of Bullying Victimization in a Multisite Sample of American Students

    ERIC Educational Resources Information Center

    Esbensen, Finn-Aage; Carson, Dena C.

    2009-01-01

    Bullying victimization is part of the adolescent experience in most societies, yet little is known about its consequences. In this article we utilize a multisite, longitudinal data set to examine the effects of being bullied. We also explore definitional and measurement issues that confound this line of research. While some researchers have relied…

  4. An Examination of Diversity within Three Southeastern Academic Libraries: A Mixed-Methods, Multi-Site Study

    ERIC Educational Resources Information Center

    Shaffer, Christopher A.

    2014-01-01

    The purpose of this study was to determine the extent to which three academic libraries in the Southeastern United States could be considered diverse. This was a multi-site, mixed methods study. It examined the climate and culture of the libraries, which was assessed through two methods; the first, through survey responses from full-time faculty…

  5. Spectroscopic Gradients in Early-type Galaxies

    NASA Astrophysics Data System (ADS)

    Buzzoni, A.; Battistini, C.; Carrasco, L.; Recillas, E.

    2009-11-01

    We review some relevant properties of the observed changes of Hβ, Mg_2, and FeI Lick indices across the surface of 25 bright elliptical galaxies. The impact of these spectroscopic gradients is briefly discussed, in the framework of the leading physical mechanisms that led to galaxy formation. In particular, three relevant evolutionary scenarios are sketched, each one able, in principle, to consistently match galaxy spectral properties and effectively constrain the composing stellar populations in these systems.

  6. Desirable evolutions of stellar spectroscopic services in the light

    NASA Astrophysics Data System (ADS)

    Lançan, A.; Prugniel, P.; Powalka, M.; Vauglin, I.

    2016-12-01

    Recent and future surveys have improved the precision and the accuracy of photometric and spectroscopic observations of remote galaxies. By examining the difficulties encountered in the modelling of these stellar populations, we identify a few key requests to future libraries of stellar spectra and to the related spectroscopic services. Beside providing data access, future services should increasingly focus on the associated on-line and off-line tools required to model and analyse galaxy spectra.

  7. Spectroscopic Properties and Potential Energy Curves of SnF +

    NASA Astrophysics Data System (ADS)

    Balasubramanian, K.; Xu, H.

    1995-06-01

    Spectroscopic properties and potential energy curves of several electronic states of SnF+ are computed using the complete active space self-consistent field (CASSCF) followed by first- and second-order configuration interaction (FOCI, SOCI) methods that include up to 1.6 million configurations. Spin-orbit effects were incorporated using the relativistic configuration interaction (RCI) method. Spectroscopic properties of several excited electronic states of SnF+ are reported, none of which is observed at present.

  8. Spectroscopic Follow Up of Kepler Planet Candidates

    NASA Astrophysics Data System (ADS)

    Latham, David W.; Cochran, W. D.; Marcy, G. W.; Buchhave, L.; Endl, M.; Isaacson, H.; Gautier, T. N.; Borucki, W. J.; Koch, D.; Kepler Team

    2010-01-01

    Spectroscopic follow-up observations play a crucial role in the confirmation and characterization of transiting planet candidates identified by Kepler. The most challenging part of this work is the determination of radial velocities with a precision approaching 1 m/s in order to derive masses from spectroscopic orbits. The most precious resource for this work is HIRES on Keck I, to be joined by HARPS-North on the William Herschel Telescope when that new spectrometer comes on line in two years. Because a large fraction of the planet candidates are in fact stellar systems involving eclipsing stars and not planets, our strategy is to start with reconnaissance spectroscopy using smaller telescopes, to sort out and reject as many of the false positives as possible before going to Keck. During the first Kepler observing season in 2009, more than 100 nights of telescope time were allocated for this work, using high-resolution spectrometers on the Lick 3.0-m Shane Telescope, the McDonald 2.7-m Reflector, the 2.5-m Nordic Optical Telescope, and the 1.5-m Tillinghast Reflector at the Whipple observatory. In this paper we will summarize the scope and organization of the spectroscopic follow-up observations, showing examples of the types of false positives found and ending with a presentation of the characteristics of a confirmed planet.

  9. Efficacy of a Process Improvement Intervention on Inmate Awareness of HIV Services: A Multi-Site Trial.

    PubMed

    Swan, Holly; Hiller, Matthew L; Albizu-García, Carmen E; Pich, Michele; Patterson, Yvonne; O'Connell, Daniel J

    2015-06-01

    The prevalence of HIV among U.S. inmates is much greater than in the general population, creating public health concerns and cost issues for the criminal justice system. The HIV Services and Treatment Implementation in Corrections protocol of the NIDA funded Criminal Justice Drug Abuse Treatment Studies cooperative tested the efficacy of an organizational process improvement strategy on improving HIV services in correctional facilities. For this paper, we analyzed efficacy of this strategy on improving inmate awareness and perceptions of HIV services. The study used a multi-site (n=28) clustered randomized trial approach. Facilities randomized to the experimental condition used a coach-driven local change team approach to improve HIV services at their facility. Facilities in the control condition were given a directive to improve HIV services on their own. Surveys about awareness and perceptions of HIV services were administered anonymously to inmates who were incarcerated in study facilities at baseline (n=1253) and follow-up (n=1048). A series of one-way ANOVAs were run to test whether there were differences between inmates in the experimental and control facilities at baseline and follow-up. Differences were observed at baseline, with the experimental group having significantly lower scores than the control group on key variables. But, at post-test, following the intervention, these differences were no longer significant. Taken in context of the findings from the main study, these results suggest that the change team approach to improving HIV services in correctional facilities is efficacious for improving inmates' awareness and perceptions of HIV services.

  10. A docking interface in the cyclin Cln2 promotes multisite phosphorylation of substrates and timely cell cycle entry

    PubMed Central

    Bhaduri, Samyabrata; Valk, Ervin; Winters, Matthew J.; Gruessner, Brian; Loog, Mart; Pryciak, Peter M.

    2014-01-01

    Summary Background Eukaryotic cell division is driven by cyclin-dependent kinases (CDKs). Distinct cyclin-CDK complexes are specialized to drive different cell cycle events, though the molecular foundations for these specializations are only partly understood. In budding yeast, the decision to begin a new cell cycle is regulated by three G1 cyclins (Cln1–Cln3). Recent studies revealed that some CDK substrates contain a novel docking motif that is specifically recognized by Cln1 and Cln2, and not by Cln3 or later S- or M-phase cyclins, but the responsible cyclin interface was unknown. Results Here, to explore the role of this new docking mechanism in the cell cycle, we first show that it is conserved in a distinct cyclin subtype (Ccn1). Then, we exploit phylogenetic variation to identify cyclin mutations that disrupt docking. These mutations disrupt binding to multiple substrates as well as the ability to use docking sites to promote efficient, multi-site phosphorylation of substrates in vitro. In cells where the Cln2 docking function is blocked, we observed reductions in the polarized morphogenesis of daughter buds and reduced ability to fully phosphorylate the G1/S transcriptional repressor Whi5. Furthermore, disruption of Cln2 docking perturbs the coordination between cell size and division, such that the G1/S transition is delayed. Conclusions The findings point to a novel substrate interaction interface on cyclins, with patterns of conservation and divergence that relate to functional distinctions among cyclin subtypes. Furthermore, this docking function helps ensure full phosphorylation of substrates with multiple phosphorylation sites, and this contributes to punctual cell cycle entry. PMID:25619768

  11. The mass ratio in spectroscopic binaries

    NASA Astrophysics Data System (ADS)

    Ducati, J. R.; Penteado, E. M.; Turcati, R.

    2003-08-01

    The process of formation of binary and multiple stars is not yet fully understood. Possibilities range from simultaneous processes of condensation from the primeval nebula, to isolated star formation and eventual capture to form a double system. Models exist that predict success probabilities for each theoretical process, and comparison with observational data is crucial. Spectroscopic binaries are specially suited to be used as observational data, since several biases that can arise from general catalogues of binary stars can be avoided, including dominance of systems with large separations between components. A very important parameter in these studies is the mass ratio, the quocient of the masses of primary and secundary members. The histogram of mass ratios provides crucial information to models of binary formation, linked to condensation processes and evolutionaty rates.In this case, spectroscopic binaries can be chosen as the observational sample, provided that the spectrum of the primary is from a non-evolved, main-sequence star,whose mass can be derived reliably from its spectral type. Defining an adequate limiting magnitude (6.5), one avoids bias from eclipsing systems with high inclinations, since nearly all systems up to 6.5 mag were detected. In this paper, a critical review is presented of the existing methods for deriving the distribution of the mass ratios from spectroscopic binary orbital data. After showing the incorrectness of some results published in the litterature, the available data (Batten's 8th Catalogue, 1989) is discussed. Simulations for several distributions of mass ratios (constant, quadratic, etc) are performed. It is shown that the existing data permits only to assert that the spectroscopic binaries with small mass ratios (q < 0.4) are more frequent that those with large mass ratios (q = 0.9 to 1.0).

  12. Spectroscopic Survey of Circumstellar Disks in Orion

    NASA Astrophysics Data System (ADS)

    Contreras, Maria; Hernandez, Jesus; Olguin, Lorenzo; Briceno, Cesar

    2013-07-01

    As a second stage of a project focused on characterizing candidate stars bearing a circumstellar disk in Orion, we present a spectroscopic follow-up of a set of about 170 bright stars. The present set of stars was selected by their optical (UBVRI) and infrared behavior in different color-color and color-magnitude diagrams. Observations were carried out at the Observatorio Astronomico Nacional located at the Sierra San Pedro Martir in B.C., Mexico and at the Observatorio Guillermo Haro in Cananea, Sonora, Mexico. Low-resolution spectra were obtained for all candidates in the sample. Using the SPTCLASS code, we have obtained spectral types and equivalent widths of the Li I 6707 and Halpha lines for each one of the stars. This project is a cornerstone of a large scale survey aimed to obtain stellar parameters in a homogeneous way using spectroscopic data. This work was partially supported by UNAM-PAPIIT grant IN-109311.

  13. Multi-site production planning in hybrid make-to-stock/make-to-order production environment

    NASA Astrophysics Data System (ADS)

    Rafiei, Hamed; Rabbani, Masoud; Kokabi, Reza

    2014-06-01

    Today competitive environment has enforced practitioners and researchers to pay great attention to issues enhancing both production and marketing competitiveness. To do so, it has been obligatory for the firms to consider production side activities while customer requirements are on the other side of competition. In this regard, hybrid make-to-stock (MTS)/make-to-order (MTO) production systems have revealed outstanding results. This paper addresses multi-site production planning of a hybrid manufacturing firm for the first time in the hybrid systems' body of literature. In this regard, a network of suppliers, manufacturers and customers is considered for which a mixed-integer mathematical model is proposed. Objective function of the proposed mathematical model seeks to maximize profitability of the manufacturing firm. Because of computational complexity of the developed mathematical model, a genetic algorithm is developed upon which numerical experiments are reported in order to show validity and applicability of the proposed model.

  14. Existence of multisite intrinsic localized modes in one-dimensional Debye crystals

    SciTech Connect

    Koukouloyannis, V.; Kourakis, I.

    2007-07-15

    The existence of highly localized multisite oscillatory structures (discrete multibreathers) in a nonlinear Klein-Gordon chain which is characterized by an inverse dispersion law is proven and their linear stability is investigated. The results are applied in the description of vertical (transverse, off-plane) dust grain motion in dusty plasma crystals, by taking into account the lattice discreteness and the sheath electric and/or magnetic field nonlinearity. Explicit values from experimental plasma discharge experiments are considered. The possibility for the occurrence of multibreathers associated with vertical charged dust grain motion in strongly coupled dusty plasmas (dust crystals) is thus established. From a fundamental point of view, this study aims at providing a rigorous investigation of the existence of intrinsic localized modes in Debye crystals and/or dusty plasma crystals and, in fact, suggesting those lattices as model systems for the study of fundamental crystal properties.

  15. Multisite silicon neural probes with integrated silicon nitride waveguides and gratings for optogenetic applications

    NASA Astrophysics Data System (ADS)

    Shim, Euijae; Chen, Yu; Masmanidis, Sotiris; Li, Mo

    2016-03-01

    Optimal optogenetic perturbation of brain circuit activity often requires light delivery in a precise spatial pattern that cannot be achieved with conventional optical fibers. We demonstrate an implantable silicon-based probe with a compact light delivery system, consisting of silicon nitride waveguides and grating couplers for out-of-plane light emission with high spatial resolution. 473 nm light is coupled into and guided in cm-long waveguide and emitted at the output grating coupler. Using the direct cut-back and out-scattering measurement techniques, the propagation optical loss of the waveguide is measured to be below 3 dB/cm. The grating couplers provide collimated light emission with sufficient irradiance for neural stimulation. Finally, a probe with multisite light delivery with three output grating emitters from a single laser input is demonstrated.

  16. The Automatic Clinical Trial: Leveraging the Electronic Medical Record in Multi-site Cancer Clinical Trials

    PubMed Central

    Krueger, Judy; Crowley, John

    2012-01-01

    Submission of data into clinical trial electronic data capture (EDC) systems currently requires redundant entry of data that already exist in the electronic medical record (EMR). Being able to automatically transfer data from the EMR to the EDC would save many hours of arduous effort, especially for multi-site data-intensive oncology trials. Standardization of the way in which data is stored and retrieved in the medical record and techniques for mining data from the unstructured narrative will provide opportunities for transferring data from EMR to EDC. As different EMRs proliferate, other technology in the form of data mining or middle tier applications are certain to provide assistance in this effort. PMID:22907283

  17. Multisite silicon neural probes with integrated silicon nitride waveguides and gratings for optogenetic applications

    PubMed Central

    Shim, Euijae; Chen, Yu; Masmanidis, Sotiris; Li, Mo

    2016-01-01

    Optimal optogenetic perturbation of brain circuit activity often requires light delivery in a precise spatial pattern that cannot be achieved with conventional optical fibers. We demonstrate an implantable silicon-based probe with a compact light delivery system, consisting of silicon nitride waveguides and grating couplers for out-of-plane light emission with high spatial resolution. 473 nm light is coupled into and guided in cm-long waveguide and emitted at the output grating coupler. Using the direct cut-back and out-scattering measurement techniques, the propagation optical loss of the waveguide is measured to be below 3 dB/cm. The grating couplers provide collimated light emission with sufficient irradiance for neural stimulation. Finally, a probe with multisite light delivery with three output grating emitters from a single laser input is demonstrated. PMID:26941111

  18. Opposing effects of Elk-1 multisite phosphorylation shape its response to ERK activation.

    PubMed

    Mylona, Anastasia; Theillet, Francois-Xavier; Foster, Charles; Cheng, Tammy M; Miralles, Francesc; Bates, Paul A; Selenko, Philipp; Treisman, Richard

    2016-10-14

    Multisite phosphorylation regulates many transcription factors, including the serum response factor partner Elk-1. Phosphorylation of the transcriptional activation domain (TAD) of Elk-1 by the protein kinase ERK at multiple sites potentiates recruitment of the Mediator transcriptional coactivator complex and transcriptional activation, but the roles of individual phosphorylation events had remained unclear. Using time-resolved nuclear magnetic resonance spectroscopy, we found that ERK2 phosphorylation proceeds at markedly different rates at eight TAD sites in vitro, which we classified as fast, intermediate, and slow. Mutagenesis experiments showed that phosphorylation of fast and intermediate sites promoted Mediator interaction and transcriptional activation, whereas modification of slow sites counteracted both functions, thereby limiting Elk-1 output. Progressive Elk-1 phosphorylation thus ensures a self-limiting response to ERK activation, which occurs independently of antagonizing phosphatase activity.

  19. Multi-site substrate binding and interplay in barley alpha-amylase 1.

    PubMed

    Nielsen, Morten Munch; Seo, Eun-Seong; Bozonnet, Sophie; Aghajari, Nushin; Robert, Xavier; Haser, Richard; Svensson, Birte

    2008-07-23

    Certain starch hydrolases possess secondary carbohydrate binding sites outside of the active site, suggesting that multi-site substrate interactions are functionally significant. In barley alpha-amylase both Tyr380, situated on a remote non-catalytic domain, and Tyr105 in subsite -6 of the active site cleft are principal carbohydrate binding residues. The dual active site/secondary site mutants Y105A/Y380A and Y105A/Y380M show that each of Tyr380 and Tyr105 is important, albeit not essential for binding, degradation, and multiple attack on polysaccharides, while Tyr105 predominates in oligosaccharide hydrolysis. Additional delicate structure/function relationships of the secondary site are uncovered using Y380A/H395A, Y380A, and H395A AMY1 mutants.

  20. Field fracturing multi-sites project. Annual report, August 1, 1995--July 31, 1996

    SciTech Connect

    1996-12-31

    The objective of the Field Fracturing Multi-Sites Project (M-Site) is to conduct experiments to definitively determine hydraulic fracture dimensions using remote well and treatment well diagnostic techniques. In addition, experiments are to be conducted to provide data that will resolve significant unknowns with regard to hydraulic fracture modeling, fracture fluid rheology and fracture treatment design. These experiments will be supported by a well-characterized subsurface environment, as well as surface facilities and equipment conducive to acquiring high-quality data. The primary Project goal is to develop a fully characterized, tight reservoir-typical, field-scale hydraulic fracturing test site to diagnose, characterize, and test hydraulic fracturing technology and performance. It is anticipated that the research work being conducted by the multi-disciplinary team of GRI and DOE contractors will lead to the development of a commercial fracture mapping tool/service.

  1. Multi-Site Quality Assurance Project Plan for Wisconsin Public Service Corporation, Peoples Gas Light and Coke Company, and North Shore Gas

    EPA Pesticide Factsheets

    This Multi-Site QAPP presents the organization, data quality objectives (DQOs), a set of anticipated activities, sample analysis, data handling and specific Quality Assurance/Quality Control (QA/QC) procedures associated with Studies done in EPA Region 5

  2. How Variability in the IRB Review Process Impacts Minimal-Risk Multisite Health Services Research

    PubMed Central

    Petersen, Laura A.; Simpson, Kate; SoRelle, Richard; Urech, Tracy; Chitwood, Supicha Sookanan

    2014-01-01

    Background The Department of Health and Human Services recently called for public comment on human subjects research protections. Objective (1) To assess variability in reviews across Institutional Review Boards (IRBs) for a multisite minimal risk trial of financial incentives for evidence-based hypertension care. (2) To quantify the impact of review determinations on site participation, budget, and timeline. Design A natural experiment occurring from multiple IRBs reviewing the same protocol for a multicenter trial (May 2005–October 2007). Participants 25 Veterans Affairs Medical Centers (VAMCs). Measurements Number of submissions, time to approval, and costs were evaluated. We compared patient complexity, academic affiliation, size, and location (urban/rural) between participating and non-participating VAMCs. Results Of 25 eligible VAMCs, 6 did not meet requirements for IRB review, and 2 declined participation. Of 17 applications, 14 were approved. This process required 115 submissions, lasted 27 months, and cost close to $170,000 in staff salaries. One IRB’s concern about incentivizing a particular medication recommended by national guidelines prompted a change in our design to broaden our inclusion criteria beyond uncomplicated hypertension. The change required amending the protocol at 14 sites to preserve internal validity. The IRBs that approved the protocol classified it as “minimal risk”. The 12 sites that ultimately participated in the trial were more likely to be urban, academically affiliated, and care for more complex patients, limiting the external validity of the trial’s findings. Limitations Because data came from a single multisite trial in the VA, which uses a two-stage review process, generalizability is limited. Conclusions Complying with IRB requirements for this minimal risk study required substantial resources and threatened the study’s internal and external validity. The current review of regulatory requirements may address some

  3. Model-data fusion across ecosystems: from multi-site optimizations to global simulations

    NASA Astrophysics Data System (ADS)

    Kuppel, S.; Peylin, P.; Maignan, F.; Chevallier, F.; Kiely, G.; Montagnani, L.; Cescatti, A.

    2014-05-01

    This study uses a variational data assimilation framework to simultaneously constrain a global ecosystem model with eddy covariance measurements of daily net carbon (NEE) and latent heat (LE) fluxes from a large number of sites grouped in seven plant functional types (PFTs). It is an attempt to bridge the gap between the numerous site-specific parameter optimization works found in the literature and the generic parameterization used by most land surface models within each PFT. The present multi-site approach allows deriving PFT-generic sets of optimized parameters enhancing the agreement between measured and simulated fluxes at most of the sites considered, with performances often comparable to those of the corresponding site-specific optimizations. Besides reducing the PFT-averaged model-data root-mean-square difference (RMSD) and the associated daily output uncertainty, the optimization improves the simulated CO2 balance at tropical and temperate forests sites. The major site-level NEE adjustments at the seasonal scale are: reduced amplitude in C3 grasslands and boreal forests, increased seasonality in temperate evergreen forests, and better model-data phasing in temperate deciduous broadleaf forests. Conversely, the poorer performances in tropical evergreen broadleaf forests points to deficiencies regarding the modeling of phenology and soil water stress for this PFT. An evaluation with data-oriented estimates of photosynthesis (GPP) and ecosystem respiration (Reco) rates indicates distinctively improved simulations of both gross fluxes. The multi-site parameter sets are then tested against CO2 concentrations measured at 53 locations around the globe, showing significant adjustments of the modeled seasonality of atmospheric CO2 concentration, whose relevance seems PFT-dependent, along with an improved interannual variability. Lastly, a global scale evaluation with remote sensing NDVI measurements indicates an improvement of the simulated seasonal variations of

  4. Model-data fusion across ecosystems: from multisite optimizations to global simulations

    NASA Astrophysics Data System (ADS)

    Kuppel, S.; Peylin, P.; Maignan, F.; Chevallier, F.; Kiely, G.; Montagnani, L.; Cescatti, A.

    2014-11-01

    This study uses a variational data assimilation framework to simultaneously constrain a global ecosystem model with eddy covariance measurements of daily net ecosystem exchange (NEE) and latent heat (LE) fluxes from a large number of sites grouped in seven plant functional types (PFTs). It is an attempt to bridge the gap between the numerous site-specific parameter optimization works found in the literature and the generic parameterization used by most land surface models within each PFT. The present multisite approach allows deriving PFT-generic sets of optimized parameters enhancing the agreement between measured and simulated fluxes at most of the sites considered, with performances often comparable to those of the corresponding site-specific optimizations. Besides reducing the PFT-averaged model-data root-mean-square difference (RMSD) and the associated daily output uncertainty, the optimization improves the simulated CO2 balance at tropical and temperate forests sites. The major site-level NEE adjustments at the seasonal scale are reduced amplitude in C3 grasslands and boreal forests, increased seasonality in temperate evergreen forests, and better model-data phasing in temperate deciduous broadleaf forests. Conversely, the poorer performances in tropical evergreen broadleaf forests points to deficiencies regarding the modelling of phenology and soil water stress for this PFT. An evaluation with data-oriented estimates of photosynthesis (GPP - gross primary productivity) and ecosystem respiration (Reco) rates indicates distinctively improved simulations of both gross fluxes. The multisite parameter sets are then tested against CO2 concentrations measured at 53 locations around the globe, showing significant adjustments of the modelled seasonality of atmospheric CO2 concentration, whose relevance seems PFT-dependent, along with an improved interannual variability. Lastly, a global-scale evaluation with remote sensing NDVI (normalized difference vegetation index

  5. A multisite validation of whole slide imaging for primary diagnosis using standardized data collection and analysis

    PubMed Central

    Wack, Katy; Drogowski, Laura; Treloar, Murray; Evans, Andrew; Ho, Jonhan; Parwani, Anil; Montalto, Michael C.

    2016-01-01

    Context: Text-based reporting and manual arbitration for whole slide imaging (WSI) validation studies are labor intensive and do not allow for consistent, scalable, and repeatable data collection or analysis. Objective: The objective of this study was to establish a method of data capture and analysis using standardized codified checklists and predetermined synoptic discordance tables and to use these methods in a pilot multisite validation study. Methods and Study Design: Fifteen case report form checklists were generated from the College of American Pathology cancer protocols. Prior to data collection, all hypothetical pairwise comparisons were generated, and a level of harm was determined for each possible discordance. Four sites with four pathologists each generated 264 independent reads of 33 cases. Preestablished discordance tables were applied to determine site by site and pooled accuracy, intrareader/intramodality, and interreader intramodality error rates. Results: Over 10,000 hypothetical pairwise comparisons were evaluated and assigned harm in discordance tables. The average difference in error rates between WSI and glass, as compared to ground truth, was 0.75% with a lower bound of 3.23% (95% confidence interval). Major discordances occurred on challenging cases, regardless of modality. The average inter-reader agreement across sites for glass was 76.5% (weighted kappa of 0.68) and for digital it was 79.1% (weighted kappa of 0.72). Conclusion: These results demonstrate the feasibility and utility of employing standardized synoptic checklists and predetermined discordance tables to gather consistent, comprehensive diagnostic data for WSI validation studies. This method of data capture and analysis can be applied in large-scale multisite WSI validations. PMID:27994941

  6. The brain-derived neurotrophic factor pathway, life stress, and chronic multi-site musculoskeletal pain

    PubMed Central

    Milaneschi, Yuri; Jansen, Rick; Elzinga, Bernet M; Dekker, Joost; Penninx, Brenda WJH

    2016-01-01

    Introduction Brain-derived neurotrophic factor (BDNF) disturbances and life stress, both independently and in interaction, have been hypothesized to induce chronic pain. We examined whether (a) the BDNF pathway (val66met genotype, gene expression, and serum levels), (b) early and recent life stress, and (c) their interaction are associated with the presence and severity of chronic multi-site musculoskeletal pain. Methods Cross-sectional data are from 1646 subjects of the Netherlands Study of Depression and Anxiety. The presence and severity of chronic multi-site musculoskeletal pain were determined using the Chronic Pain Grade (CPG) questionnaire. The BDNF val66met polymorphism, BDNF gene expression, and BDNF serum levels were measured. Early life stress before the age of 16 was assessed by calculating a childhood trauma index using the Childhood Trauma Interview. Recent life stress was assessed as the number of recent adverse life events using the List of Threatening Events Questionnaire. Results Compared to val66val, BDNF met carriers more often had chronic pain, whereas no differences were found for BDNF gene expression and serum levels. Higher levels of early and recent stress were both associated with the presence and severity of chronic pain (p < 0.001). No interaction effect was found for the BDNF pathway with life stress in the associations with chronic pain presence and severity. Conclusions This study suggests that the BDNF gene marks vulnerability for chronic pain. Although life stress did not alter the impact of BDNF on chronic pain, it seems an independent factor in the onset and persistence of chronic pain. PMID:27145806

  7. Biophysical Modelling to Simulate the Response to Multisite Left Ventricular Stimulation using a Quadripolar Pacing Lead

    PubMed Central

    Niederer, SA; Shetty, AK; Plank, G; Bostock, J; Razavi, R; Smith, NP; Rinaldi, CA

    2016-01-01

    Background Response to Cardiac Resynchronisation Therapy (CRT) is reduced in patients with postero-lateral scar. Multipolar pacing leads offer the ability to select desirable pacing sites and/or stimulate from multiple pacing sites concurrently using a single lead position. Despite this potential, the clinical evaluation and identification of metrics for optimisation of multisite CRT (MCRT) has not been performed. Methods The efficacy of MCRT via a quadripolar lead with two LV pacing sites in conjunction with RV pacing was compared with single site LV pacing using a coupled electro-mechanical biophysical model of the human heart with no, mild or severe scar in the LV postero-lateral wall. Result The maximum dP/dtmax improvement from baseline was 21%, 23%, 21% for standard CRT vs 22%, 24%, 25% for MCRT for no, mild and severe scar, respectively. In the presence of severe scar there was an incremental benefit of multisite vs standard CRT (25% vs 21%, 19% relative improvement). Minimizing total activation time (analogous to QRS duration) or minimizing the activation time of short axis slices of the heart did not correlate with CRT response. The peak electrical activation wave area in the LV corresponded with CRT response with an R2 value between 0.42-0.75. Conclusion Biophysical modelling predicts that in the presence of postero-lateral scar MCRT offers an improved response over conventional CRT. Maximising the activation wave area in the LV had the most consistent correlation with CRT response, independent of pacing protocol, scar size or lead location. PMID:22040178

  8. Neisseria meningitidis Type IV Pili Composed of Sequence Invariable Pilins Are Masked by Multisite Glycosylation

    PubMed Central

    Gault, Joseph; Ferber, Mathias; Machata, Silke; Imhaus, Anne-Flore; Malosse, Christian; Charles-Orszag, Arthur; Millien, Corinne; Bouvier, Guillaume; Bardiaux, Benjamin; Péhau-Arnaudet, Gérard; Klinge, Kelly; Podglajen, Isabelle; Ploy, Marie Cécile; Seifert, H. Steven; Nilges, Michael; Chamot-Rooke, Julia; Duménil, Guillaume

    2015-01-01

    The ability of pathogens to cause disease depends on their aptitude to escape the immune system. Type IV pili are extracellular filamentous virulence factors composed of pilin monomers and frequently expressed by bacterial pathogens. As such they are major targets for the host immune system. In the human pathogen Neisseria meningitidis, strains expressing class I pilins contain a genetic recombination system that promotes variation of the pilin sequence and is thought to aid immune escape. However, numerous hypervirulent clinical isolates express class II pilins that lack this property. This raises the question of how they evade immunity targeting type IV pili. As glycosylation is a possible source of antigenic variation it was investigated using top-down mass spectrometry to provide the highest molecular precision on the modified proteins. Unlike class I pilins that carry a single glycan, we found that class II pilins display up to 5 glycosylation sites per monomer on the pilus surface. Swapping of pilin class and genetic background shows that the pilin primary structure determines multisite glycosylation while the genetic background determines the nature of the glycans. Absence of glycosylation in class II pilins affects pilus biogenesis or enhances pilus-dependent aggregation in a strain specific fashion highlighting the extensive functional impact of multisite glycosylation. Finally, molecular modeling shows that glycans cover the surface of class II pilins and strongly decrease antibody access to the polypeptide chain. This strongly supports a model where strains expressing class II pilins evade the immune system by changing their sugar structure rather than pilin primary structure. Overall these results show that sequence invariable class II pilins are cloaked in glycans with extensive functional and immunological consequences. PMID:26367394

  9. THE zCOSMOS 10k-BRIGHT SPECTROSCOPIC SAMPLE

    SciTech Connect

    Lilly, Simon J.; Maier, Christian; Carollo, Marcella; Caputi, Karina; Le Brun, Vincent; Kneib, Jean-Paul; Le Fevre, Olivier; De la Torre, Sylvain; De Ravel, Loic; Mainieri, Vincenzo; Mignoli, Marco; Zamorani, Gianni; Bardelli, Sandro; Bolzonella, Micol; Coppa, Graziano; Scodeggio, Marco; Contini, Thierry; Bongiorno, Angela; Cucciati, Olga

    2009-10-01

    We present spectroscopic redshifts of a large sample of galaxies with I {sub AB} < 22.5 in the COSMOS field, measured from spectra of 10,644 objects that have been obtained in the first two years of observations in the zCOSMOS-bright redshift survey. These include a statistically complete subset of 10,109 objects. The average accuracy of individual redshifts is 110 km s{sup -1}, independent of redshift. The reliability of individual redshifts is described by a Confidence Class that has been empirically calibrated through repeat spectroscopic observations of over 600 galaxies. There is very good agreement between spectroscopic and photometric redshifts for the most secure Confidence Classes. For the less secure Confidence Classes, there is a good correspondence between the fraction of objects with a consistent photometric redshift and the spectroscopic repeatability, suggesting that the photometric redshifts can be used to indicate which of the less secure spectroscopic redshifts are likely right and which are probably wrong, and to give an indication of the nature of objects for which we failed to determine a redshift. Using this approach, we can construct a spectroscopic sample that is 99% reliable and which is 88% complete in the sample as a whole, and 95% complete in the redshift range 0.5 < z < 0.8. The luminosity and mass completeness levels of the zCOSMOS-bright sample of galaxies is also discussed.

  10. Spectroscopic classification of supernova candidates

    NASA Astrophysics Data System (ADS)

    Hodgkin, S. T.; Hall, A.; Fraser, M.; Campbell, H.; Wyrzykowski, L.; Kostrzewa-Rutkowska, Z.; Pietro, N.

    2014-09-01

    We report the spectroscopic classification of four supernovae at the 2.5m Isaac Newton Telescope on La Palma, using the Intermediate Dispersion Spectrograph and the R300V grating (3500-8000 Ang; ~6 Ang resolution).

  11. Spectroscopic Detection of Pathogens

    SciTech Connect

    ALAM,M. KATHLEEN; TIMLIN,JERILYN A.; MARTIN,LAURA E.; HJELLE,DRIAN; LYONS,RICK; GARRISON,KRISTIN

    2000-11-01

    The goal of this LDRD Research project was to provide a preliminary examination of the use of infrared spectroscopy as a tool to detect the changes in cell cultures upon activation by an infectious agent. Due to a late arrival of funding, only 5 months were available to transfer and setup equipment at UTTM,develop cell culture lines, test methods of in-situ activation and collect kinetic data from activated cells. Using attenuated total reflectance (ATR) as a sampling method, live cell cultures were examined prior to and after activation. Spectroscopic data were collected from cells immediately after activation in situ and, in many cases for five successive hours. Additional data were collected from cells activated within a test tube (pre-activated), in both transmission mode as well as in ATR mode. Changes in the infrared data were apparent in the transmission data collected from the pre-activated cells as well in some of the pre-activated ATR data. Changes in the in-situ activated spectral data were only occasionally present due to (1) the limited time cells were studied and (2) incomplete activation. Comparison of preliminary data to infrared bands reported in the literature suggests the primary changes seen are due an increase in ribonucleic acid (RNA) production. This work will be continued as part of a 3 year DARPA grant.

  12. Spectroscopic Classification of PS16chs with SOAR/Goodman

    NASA Astrophysics Data System (ADS)

    Miller, J. A.; Hounsell, R. A.; Pan, Y.-C.; Foley, R. J.; Jha, S. W.; Rest, A.; Scolnic, D.

    2016-05-01

    We report the classification of PS16chs from spectroscopic observation with the Goodman spectrograph on the SOAR telescope. The observation was made on 2016 May 08 UT. We classify PS16chs as a SN Ia near maximum light at z = 0.19.

  13. Mitotic activation of the DISC1-inducible cyclic AMP phosphodiesterase-4D9 (PDE4D9), through multi-site phosphorylation, influences cell cycle progression.

    PubMed

    Sheppard, Catherine L; Lee, Louisa C Y; Hill, Elaine V; Henderson, David J P; Anthony, Diana F; Houslay, Daniel M; Yalla, Krishna C; Cairns, Lynne S; Dunlop, Allan J; Baillie, George S; Huston, Elaine; Houslay, Miles D

    2014-09-01

    In Rat-1 cells, the dramatic decrease in the levels of both intracellular cyclic 3'5' adenosine monophosphate (cyclic AMP; cAMP) and in the activity of cAMP-activated protein kinase A (PKA) observed in mitosis was paralleled by a profound increase in cAMP hydrolyzing phosphodiesterase-4 (PDE4) activity. The decrease in PKA activity, which occurs during mitosis, was attributable to PDE4 activation as the PDE4 selective inhibitor, rolipram, but not the phosphodiesterase-3 (PDE3) inhibitor, cilostamide, specifically ablated this cell cycle-dependent effect. PDE4 inhibition caused Rat-1 cells to move from S phase into G2/M more rapidly, to transit through G2/M more quickly and to remain in G1 for a longer period. Inhibition of PDE3 elicited no observable effects on cell cycle dynamics. Selective immunopurification of each of the four PDE4 sub-families identified PDE4D as being selectively activated in mitosis. Subsequent analysis uncovered PDE4D9, an isoform whose expression can be regulated by Disrupted-In-Schizophrenia 1 (DISC1)/activating transcription factor 4 (ATF4) complex, as the sole PDE4 species activated during mitosis in Rat-1 cells. PDE4D9 becomes activated in mitosis through dual phosphorylation at Ser585 and Ser245, involving the combined action of ERK and an unidentified 'switch' kinase that has previously been shown to be activated by H2O2. Additionally, in mitosis, PDE4D9 also becomes phosphorylated at Ser67 and Ser81, through the action of MK2 (MAPKAPK2) and AMP kinase (AMPK), respectively. The multisite phosphorylation of PDE4D9 by all four of these protein kinases leads to decreased mobility (band-shift) of PDE4D9 on SDS-PAGE. PDE4D9 is predominantly concentrated in the perinuclear region of Rat-1 cells but with a fraction distributed asymmetrically at the cell margins. Our investigations demonstrate that the diminished levels of cAMP and PKA activity that characterise mitosis are due to enhanced cAMP degradation by PDE4D9. PDE4D9, was found to

  14. A MultiSite GatewayTM vector set for the functional analysis of genes in the model Saccharomyces cerevisiae

    PubMed Central

    2012-01-01

    Background Recombinatorial cloning using the GatewayTM technology has been the method of choice for high-throughput omics projects, resulting in the availability of entire ORFeomes in GatewayTM compatible vectors. The MultiSite GatewayTM system allows combining multiple genetic fragments such as promoter, ORF and epitope tag in one single reaction. To date, this technology has not been accessible in the yeast Saccharomyces cerevisiae, one of the most widely used experimental systems in molecular biology, due to the lack of appropriate destination vectors. Results Here, we present a set of three-fragment MultiSite GatewayTM destination vectors that have been developed for gene expression in S. cerevisiae and that allow the assembly of any promoter, open reading frame, epitope tag arrangement in combination with any of four auxotrophic markers and three distinct replication mechanisms. As an example of its applicability, we used yeast three-hybrid to provide evidence for the assembly of a ternary complex of plant proteins involved in jasmonate signalling and consisting of the JAZ, NINJA and TOPLESS proteins. Conclusion Our vectors make MultiSite GatewayTM cloning accessible in S. cerevisiae and implement a fast and versatile cloning method for the high-throughput functional analysis of (heterologous) proteins in one of the most widely used model organisms for molecular biology research. PMID:22994806

  15. Exploring the spectroscopic properties of relic radiogalaxies

    NASA Astrophysics Data System (ADS)

    Capetti, A.; Robinson, A.; Baldi, R. D.; Buttiglione, S.; Axon, D. J.; Celotti, A.; Chiaberge, M.

    2013-03-01

    From an optical spectroscopic survey of 3CR radiogalaxies (RGs) with z < 0.3, we discovered three objects characterized by an extremely low level of gas excitation and a large deficit of line emission with respect to RGs of similar radio luminosity. We interpreted these objects as relic active galactic nuclei (AGN), i.e., sources observed after a large drop in their nuclear activity. We here present new spectroscopic observations for these three galaxies and for a group of "candidate" relics. None of the candidates can be convincingly confirmed. From the new data for the three relics, we estimate the density of the line-emitting gas. This enables us to explore the temporal evolution of the line ratios after the AGN "death". The characteristic timescale is the light-crossing time of the emission-line region, a few ~103 years, too short to correspond to a substantial population of relic RGs. Additional mechanisms of gas ionization, such as "relic shocks" from their past high power phase or stellar sources, should also be considered to account for the spectroscopic properties of the relic RGs. Relic RGs appear to be a mixed bag of sources in different phases of evolution, including AGN recently (~104 years ago) quenched, galaxies that have been inactive for at least ~106 years, and objects caught during the transition from a powerful RG to a low power FR I source. Based on observations made with the Italian Telescopio Nazionale Galileo operated on the island of La Palma by the Centro Galileo Galilei of INAF (Istituto Nazionale di Astrofisica) at the Spanish Observatorio del Roque del los Muchachos of the Instituto de Astrofisica de Canarias.

  16. Quasi-static and multi-site high velocity impact response of composite structures

    NASA Astrophysics Data System (ADS)

    Deka, Lakshya

    Understanding of low and high velocity transverse impact of laminated fiber reinforced composites is of interest in military, aerospace, marine and civilian structures. Recent advances in the field of numerical simulation provide a means of predicting the performance characteristics of layered materials for impact protection. The overall objective of this work is to investigate the behavior of laminated composites which include both thermoplastic and thermoset systems subjected to quasi-static, low and high velocity impact; both from an experimental and numerical modeling view point. To analyze this problem, a series of quasi-static, low and high velocity impact tests have been performed on laminated composite plates namely E-glass/polypropylene, S2-glass/epoxy and carbon/polyphenylene sulphide. To analyze the perforation mechanism, ballistic limit and damage evolution, an explicit three-dimensional finite element code LS-DYNA is used. Selecting proper material models and contact definition is one of the major criteria for obtaining accurate numerical simulation. Material model 162 (MAT 162), a progressive failure model based on modified Hashin's criteria and continuum damage mechanics (CDM) has been assigned to predict failure of the laminate. This approach is used because during transverse impact, a composite laminate undergoes progressive damage. The laminate and the projectile are meshed using brick elements with single integration points. The impact velocity ranges from 180 to 400 m s -1. This work focuses on three main aspects; (i) To obtain static and dynamic material properties to incorporate into the finite element model and predict the ballistic limit of a composite laminate based on the information from quasi-static punch shear test; (ii) To understand penetration, material erosion, ballistic limit and delamination mechanisms for single and multi-site high velocity (or ballistic) impact of composite laminates; (iii) To investigate the different failure

  17. UV Spectroscopic Indices of Galactic Globular Clusters

    NASA Astrophysics Data System (ADS)

    Morales-Hernández, J.; Chávez, M.; Bertone, E.; Buzzoni, A.; Bressan, A.

    2009-03-01

    We present the calculation of a set of 12 mid-ultraviolet (1900-3200 Å) spectroscopic indices for a sample of 15 galactic globular clusters (GGC) observed with the International Ultraviolet Explorer (IUE). We explore the dependence of the indices on age and metal abundance. We found that five indices (BL 2538, Fe II 2609, Mg II 2800, Mg I 2852 and Mg Wide) display a remarkably good correlation with [Fe/H]. With respect to age, only one index (BL 2740) shows a good correlation. Results from theoretical simple stellar populations well reproduce the global trends of indices vs. [Fe/H].

  18. Preliminary results on the fracture analysis of multi-site cracking of lap joints in aircraft skins

    NASA Astrophysics Data System (ADS)

    Beuth, J. L., Jr.; Hutchinson, John W.

    1992-07-01

    Results of a fracture mechanics analysis relevant to fatigue crack growth at rivets in lap joints of aircraft skins are presented. Multi-site damage (MSD) is receiving increased attention within the context of problems of aging aircraft. Fracture analyses previously carried out include small-scale modeling of rivet/skin interactions, larger-scale two-dimensional models of lap joints similar to that developed here, and full scale three-dimensional models of large portions of the aircraft fuselage. Fatigue testing efforts have included flat coupon specimens, two-dimensional lap joint tests, and full scale tests on specimens designed to closely duplicate aircraft sections. Most of this work is documented in the proceedings of previous symposia on the aging aircraft problem. The effect MSD has on the ability of skin stiffeners to arrest the growth of long skin cracks is a particularly important topic that remains to be addressed. One of the most striking features of MSD observed in joints of some test sections and in the joints of some of the older aircraft fuselages is the relative uniformity of the fatigue cracks from rivet to rivet along an extended row of rivets. This regularity suggests that nucleation of the cracks must not be overly difficult. Moreover, it indicates that there is some mechanism which keeps longer cracks from running away from shorter ones, or, equivalently, a mechanism for shorter cracks to catch-up with longer cracks. This basic mechanism has not been identified, and one of the objectives of the work is to see to what extent the mechanism is revealed by a fracture analysis of the MSD cracks. Another related aim is to present accurate stress intensity factor variations with crack length which can be used to estimate fatigue crack growth lifetimes once cracks have been initiated. Results are presented which illustrate the influence of load shedding from rivets with long cracks to neighboring rivets with shorter cracks. Results are also included

  19. Preliminary results on the fracture analysis of multi-site cracking of lap joints in aircraft skins

    NASA Technical Reports Server (NTRS)

    Beuth, J. L., Jr.; Hutchinson, John W.

    1992-01-01

    Results of a fracture mechanics analysis relevant to fatigue crack growth at rivets in lap joints of aircraft skins are presented. Multi-site damage (MSD) is receiving increased attention within the context of problems of aging aircraft. Fracture analyses previously carried out include small-scale modeling of rivet/skin interactions, larger-scale two-dimensional models of lap joints similar to that developed here, and full scale three-dimensional models of large portions of the aircraft fuselage. Fatigue testing efforts have included flat coupon specimens, two-dimensional lap joint tests, and full scale tests on specimens designed to closely duplicate aircraft sections. Most of this work is documented in the proceedings of previous symposia on the aging aircraft problem. The effect MSD has on the ability of skin stiffeners to arrest the growth of long skin cracks is a particularly important topic that remains to be addressed. One of the most striking features of MSD observed in joints of some test sections and in the joints of some of the older aircraft fuselages is the relative uniformity of the fatigue cracks from rivet to rivet along an extended row of rivets. This regularity suggests that nucleation of the cracks must not be overly difficult. Moreover, it indicates that there is some mechanism which keeps longer cracks from running away from shorter ones, or, equivalently, a mechanism for shorter cracks to catch-up with longer cracks. This basic mechanism has not been identified, and one of the objectives of the work is to see to what extent the mechanism is revealed by a fracture analysis of the MSD cracks. Another related aim is to present accurate stress intensity factor variations with crack length which can be used to estimate fatigue crack growth lifetimes once cracks have been initiated. Results are presented which illustrate the influence of load shedding from rivets with long cracks to neighboring rivets with shorter cracks. Results are also included

  20. Multi-site, multi-year monitoring of the oscillating Algol-type eclipsing binary CT Herculis

    NASA Astrophysics Data System (ADS)

    Lampens, P.; Strigachev, A.; Kim, S.-L.; Rodríguez, E.; López-González, M. J.; Vidal-Saínz, J.; Mkrtichian, D.; Koo, J.-R.; Kang, Y. B.; van Cauteren, P.; Wils, P.; Kraicheva, Z.; Dimitrov, D.; Southworth, J.; García Melendo, E.; Gómez Forellad, J. M.

    2011-10-01

    We present the results of a multi-site photometric campaign carried out in 2004-2008 for the Algol-type eclipsing binary system CT Her, the primary component of which displays δ Scuti-type oscillations. Our data consist of differential light curves collected in the filters B and V, which were analysed using the method of Wilson-Devinney (Phoebe). After identifying an adequate binary model and removing the best-fit light-curve solution, we performed a Fourier analysis of the residual B and V light curves to investigate the pulsational behaviour. We confirm the presence of rapid pulsations with a main period of 27.2 min. Up to eight significant frequencies with semi-amplitudes in the range 3 to 1 mmag were detected, all of which lie in the frequency range 43.5-53.5 d-1. This result is independent of the choice of the primary's effective temperature (8200 or 8700 K) since the light-curve models of the binary are very similar in both cases. This is yet another case of a complex frequency spectrum observed for an accreting δ Scuti-type star (after Y Cam). In addition, we demonstrate that the amplitudes of several pulsation frequencies provide evidence of variability on timescales as short as 1-2 years, perhaps even less. Moreover, our analysis takes into account some recently acquired spectra, from which we obtained the corresponding radial velocities for the years 2007-2009. Investigation of the O-C diagram shows that further monitoring of the epochs of eclipse minima of CT Her will cast new light on the evolution of its orbital period. Based on photometric data collected at the observatories listed in Table 1 and spectra acquired at the NAO, Bulgaria, and Calar Alto Observatory, Spain. The Skinakas Observatory is a collaborative project of the University of Crete, the Foundation for Research and Technology - Hellas, and the Max-Planck-Institut für Extraterrestrische Physik.Full Tables 3, 4, 9 and 12 are only available at the CDS via anonymous ftp to cdsarc

  1. Trauma Center Youth Violence Screening and Brief Interventions: A Multisite Pilot Feasibility Study.

    PubMed

    Kazemi, Donna M; Jacobs, David G; Portwood, Sharon G; Veach, Laura; Zhou, Weihua; Hurley, Melissa Johnson

    2017-04-01

    Every day, 16 American youths between the ages of 10 and 24 years are murdered; 84% of these fatalities involve a firearm. Nearly half of traumatic youth deaths result from violence-related injuries. In 2013, 580,250 youth suffered nonfatal, assault-related injuries, necessitating emergency department treatment. The aim of this multisite pilot study was to examine the process, feasibility, and challenges of violence brief interventions (VBIs). The participants were youth between 15 and 25 years of age, at 2 major Level 1 trauma centers (TCs; TC1, TC2) in the Southeastern United States. Eligible participants (N = 38; TC1: n = 20, TC2: n = 18) received at least 1 VBI during their hospital stay, which provided information about individual screening results and elicited patients' perspectives on violent and risky behaviors. More participants at TC2 than at TC1 completed 2 VBI sessions. Barriers to and support of implementation were identified at both sites, and factors for improving implementation were identified, including the need for staff support through clinical guidelines and coordinated prevention and outreach programs. Further research is needed to identify factors for successful implementation of VBIs in TCs.

  2. Introduction to the GRI/DOE Field Fracturing Multi-Site Project

    SciTech Connect

    Peterson, R.E.; Middlebrook, M.L.; Warpinski, N.R.; Cleary, M.P.; Branagan, P.T.

    1993-12-31

    The objective of the Field Fracturing Multi-Sites Project is to conduct field experiments and analyze data that will result in definitive determinations of hydraulic fracture dimensions using remote well and treatment well diagnostic techniques. In addition, experiments will be conducted to provide data that will resolve significant unknowns with regard to hydraulic fracture modeling, fracture fluid rheology and fracture treatment design. These experiments will be supported by a well-characterized subsurface environment, as well as surface facilities and equipment that are conducive to acquiring high-quality data. It is anticipated that the primary benefit of the project experiments will be the development and widespread commercialization of new fracture diagnostics technologies to determine fracture length, height, width and azimuth. Data resulting from these new technologies can then be used to prove and refine the 3D fracture model mechanisms. It is also anticipated that data collected and analyzed in the project will define the correct techniques for determining fracture closure pressure. The overall impact of the research will be to provide a foundation for a fracture diagnostic service industry and hydraulic fracture optimization based on measured fracture response.

  3. On-chip, multisite extracellular and intracellular recordings from primary cultured skeletal myotubes

    PubMed Central

    Rabieh, Noha; Ojovan, Silviya M.; Shmoel, Nava; Erez, Hadas; Maydan, Eilon; Spira, Micha E.

    2016-01-01

    In contrast to the extensive use of microelectrode array (MEA) technology in electrophysiological studies of cultured neurons and cardiac muscles, the vast field of skeletal muscle research has yet to adopt the technology. Here we demonstrate an empowering MEA technology for high quality, multisite, long-term electrophysiological recordings from cultured skeletal myotubes. Individual rat skeletal myotubes cultured on micrometer sized gold mushroom-shaped microelectrode (gMμE) based MEA tightly engulf the gMμEs, forming a high seal resistance between the myotubes and the gMμEs. As a consequence, spontaneous action potentials generated by the contracting myotubes are recorded as extracellular field potentials with amplitudes of up to 10 mV for over 14 days. Application of a 10 ms, 0.5–0.9 V voltage pulse through the gMμEs electroporated the myotube membrane, and transiently converted the extracellular to intracellular recording mode for 10–30 min. In a fraction of the cultures stable attenuated intracellular recordings were spontaneously produced. In these cases or after electroporation, subthreshold spontaneous potentials were also recorded. The introduction of the gMμE-MEA as a simple-to-use, high-quality electrophysiological tool together with the progress made in the use of cultured human myotubes opens up new venues for basic and clinical skeletal muscle research, preclinical drug screening, and personalized medicine. PMID:27812002

  4. Multisite Promiscuity in the Processing of Endogenous Substrates By Human Carboxylesterase 1

    SciTech Connect

    Bencharit, S.; Edwards, C.C.; Morton, C.L.; Howard-Williams, E.L.; Kuhn, P.; Potter, P.M.; Redinbo, M.R.; /North Carolina U. /St. Jude Children's Hosp., Memphis /SLAC, SSRL

    2007-01-16

    Human carboxylesterase 1 (hCE1) is a drug and endobiotic-processing serine hydrolase that exhibits relatively broad substrate specificity. It has been implicated in a variety of endogenous cholesterol metabolism pathways including the following apparently disparate reactions: cholesterol ester hydrolysis (CEH), fatty acyl Coenzyme A hydrolysis (FACoAH), acyl-Coenzyme A:cholesterol acyltransfer (ACAT), and fatty acyl ethyl ester synthesis (FAEES). The structural basis for the ability of hCE1 to perform these catalytic actions involving large substrates and products has remained unclear. Here we present four crystal structures of the hCE1 glycoprotein in complexes with the following endogenous substrates or substrate analogues: Coenzyme A, the fatty acid palmitate, and the bile acids cholate and taurocholate. While the active site of hCE1 was known to be promiscuous and capable of interacting with a variety of chemically distinct ligands, these structures reveal that the enzyme contains two additional ligand-binding sites and that each site also exhibits relatively non-specific ligand-binding properties. Using this multisite promiscuity, hCE1 appears structurally capable of assembling several catalytic events depending, apparently, on the physiological state of the cellular environment. These results expand our understanding of enzyme promiscuity and indicate that, in the case of hCE1, multiple non-specific sites are employed to perform distinct catalytic actions.

  5. Out of the frying pan? Streamlining the ethics review process of multisite qualitative research projects.

    PubMed

    Iedema, Rick A M; Allen, Suellen; Britton, Kate; Hor, Suyin

    2013-05-01

    This paper describes the ethics approval processes for two multicentre, nationwide, qualitative health service research projects. The paper explains that the advent of the National Ethics Application Form has brought many improvements, but that attendant processes put in place at local health network and Human Research Ethics Committee levels may have become significantly more complicated, particularly for innovative qualitative research projects. The paper raises several questions based on its analysis of ethics application processes currently in place. WHAT IS KNOWN ABOUT THE TOPIC? The complexity of multicentre research ethics applications for research in health services has been addressed by the introduction of the National Ethics Application Form. Uptake of the form across the country's human research ethics committees has been uneven. WHAT DOES THIS PAPER ADD? This paper adds detailed insight into the ethics application process as it is currently enacted across the country. The paper details this process with reference to difficulties faced by multisite and qualitative studies in negotiating access to research sites, ethics committees' relative unfamiliarity with qualitative research , and apparent tensions between harmonisation and local sites' autonomy in approving research. WHAT ARE THE IMPLICATIONS FOR PRACTITIONERS? Practitioners aiming to engage in research need to be aware that ethics approval takes place in an uneven procedural landscape, made up of variable levels of ethics approval harmonization and intricate governance or site-specific assessment processes.

  6. A Multisite Study of the Prevalence of HIV With Rapid Testing in Mental Health Settings

    PubMed Central

    Blank, Michael B.; Himelhoch, Seth S.; Balaji, Alexandra B.; Metzger, David S.; Dixon, Lisa B.; Rose, Charles E.; Oraka, Emeka; Davis-Vogel, Annet; Thompson, William W.; Heffelfinger, James D.

    2014-01-01

    Objectives. We estimated HIV prevalence and risk factors among persons receiving mental health treatment in Philadelphia, Pennsylvania, and Baltimore, Maryland, January 2009 to August 2011. Methods. We used a multisite, cross-sectional design stratified by clinical setting. We tested 1061 individuals for HIV in university-based inpatient psychiatric units (n = 287), intensive case-management programs (n = 273), and community mental health centers (n = 501). Results. Fifty-one individuals (4.8%) were HIV-infected. Confirmed positive HIV tests were 5.9% (95% confidence interval [CI] = 3.7%, 9.4%) for inpatient units, 5.1% (95% CI = 3.1%, 8.5%) for intensive case-management programs, and 4.0% (95% CI = 2.6%, 6.1%) for community mental health centers. Characteristics associated with HIV included Black race, homosexual or bisexual identity, and HCV infection. Conclusions. HIV prevalence for individuals receiving mental health services was about 4 times as high as in the general population. We found a positive association between psychiatric symptom severity and HIV infection, indicating that engaging persons with mental illness in appropriate mental health treatment may be important to HIV prevention. These findings reinforce recommendations for routine HIV testing in all clinical settings to ensure that HIV-infected persons receiving mental health services are identified and referred to timely infectious disease care. PMID:24524493

  7. Design, simplified cloning, and in-silico analysis of multisite small interfering RNA-targeting cassettes

    PubMed Central

    Baghban-Kohnehrouz, Bahram; Nayeri, Shahnoush

    2016-01-01

    Multiple gene silencing is being required to target and tangle metabolic pathways in eukaryotes and researchers have to develop a subtle method for construction of RNA interference (RNAi) cassettes. Although, several vectors have been developed due to different screening and cloning strategies but still some potential limitations remain to be dissolved. Here, we worked out a simple cloning strategy to develop multisite small interfering RNA (siRNA) cassette from different genes by two cloning steps. In this method, effective siRNA sites in the target messenger RNAs (mRNAs) were determined using in silico analysis and consecutively arranged to reduce length of inverted repeats. Here, we used one-step (polymerase chain reaction) PCR by designed long primer sets covering the selected siRNA sites. Rapid screening, cost-effective and shorten procedure are advantages of this method compare to PCR classic cloning. Validity of constructs was confirmed by optimal centroid secondary structures with high stability in plants. PMID:27844018

  8. Evaluation of Speech-Perception Training for Hearing Aid Users: A Multisite Study in Progress

    PubMed Central

    Miller, James D.; Watson, Charles S.; Dubno, Judy R.; Leek, Marjorie R.

    2015-01-01

    Following an overview of theoretical issues in speech-perception training and of previous efforts to enhance hearing aid use through training, a multisite study, designed to evaluate the efficacy of two types of computerized speech-perception training for adults who use hearing aids, is described. One training method focuses on the identification of 109 syllable constituents (45 onsets, 28 nuclei, and 36 codas) in quiet and in noise, and on the perception of words in sentences presented in various levels of noise. In a second type of training, participants listen to 6- to 7-minute narratives in noise and are asked several questions about each narrative. Two groups of listeners are trained, each using one of these types of training, performed in a laboratory setting. The training for both groups is preceded and followed by a series of speech-perception tests. Subjects listen in a sound field while wearing their hearing aids at their usual settings. The training continues over 15 to 20 visits, with subjects completing at least 30 hours of focused training with one of the two methods. The two types of training are described in detail, together with a summary of other perceptual and cognitive measures obtained from all participants. PMID:27587914

  9. Fertility awareness / natural family planning for adolescents and their families: report of multisite pilot project.

    PubMed

    Klaus, H; Bryan, L M; Bryant, M L; Fagan, M U; Harrigan, M B; Kearns, F

    1987-01-01

    Fertility awareness is experiential learning about cyclic fertility. This awareness, used as a family planning method, differs from contraception because it does not isolate the procreative capacity of either partner. The acceptability and effect of teaching fertility awareness on teen sexual activity and decision making was tested in a multisite pilot program which taught fertility awareness via the prospective marker of the cervical mucus (ovulation method of natural family planning). 200 US and 35 Guatemalan volunteer women ages 15-17 in a structured 1 year curriculum, monitored cycle charting and explored the implications of experiencing one's signs of fertility. Control subjects were recruited from the general population and from family planning clinics. 9% of the US study group were sexually active prior to entry. By cycle 12, 1/2 had discontinued activity. Conception rate was 0.0044. The continuation rate dropped from 90% at cycle 7 to 71% at cycle 8 due to scheduling constraints for 2 classes and to 57% at cycle 12. Postprogram follow-up of early leavers showed only 1/3 the expected rate of onset of sexual activity and pregnancy. Parent involvement correlated positively with postponement and/or discontinuation of sexual activity. Reported movement away from peer group pressure appeared 3 months after entry.

  10. Fracture analysis of multi-site cracking in fuselage lap joints

    NASA Astrophysics Data System (ADS)

    Beuth, J. L.; Hutchinson, J. W.

    1994-09-01

    A two-dimensional plane stress elastic fracture mechanics analysis of a cracked lap joint fastened by rigid pins is presented and results are applied to the problem of multi-site damage (MSD) in riveted lap joints of aircraft fuselage skins. Two problems are addressed, the problem of equal length MSD cracks and the problem of alternating length MSD cracks. For the problem of equal length cracks, two models of rivet/skin interactions are studied and the role of residual stresses due to the riveting process is explored. Stress intensity factors are obtained as a function of normalized crack length. Also, the load distribution among rivet rows and the compliance change of the joint due to MSD cracking are obtained. For the problem of alternating length cracks, attention is focussed on how load is distributed between columns of rivets and how this load shedding can alter crack tip stress intensity factors. The equal and alternating length crack analyses reveal no clear-cut mechanism to explain the relative uniformity of fatigue cracks emerging from lap joint rivet holes in actual aircraft and in mechanical lap joint tests.

  11. Differential adaptation drives ecological speciation in campions (Silene): evidence from a multi-site transplant experiment.

    PubMed

    Favre, Adrien; Widmer, Alex; Karrenberg, Sophie

    2017-02-01

    In order to investigate the role of differential adaptation for the evolution of reproductive barriers, we conducted a multi-site transplant experiment with the dioecious sister species Silene dioica and S. latifolia and their hybrids. Crosses within species as well as reciprocal first-generation (F1 ) and second-generation (F2 ) interspecific hybrids were transplanted into six sites, three within each species' habitat. Survival and flowering were recorded over 4 yr. At all transplant sites, the local species outperformed the foreign species, reciprocal F1 hybrids performed intermediately and F2 hybrids underperformed in comparison to F1 hybrids (hybrid breakdown). Females generally had slightly higher cumulative fitness than males in both within- and between-species crosses and we thus found little evidence for Haldane's rule acting on field performance. The strength of selection against F1 and F2 hybrids as well as hybrid breakdown increased with increasing strength of habitat adaptation (i.e. the relative fitness difference between the local and the foreign species) across sites. Our results suggest that differential habitat adaptation led to ecologically dependent post-zygotic reproductive barriers and drives divergence and speciation in this Silene system.

  12. Multisite updating Markov chain Monte Carlo algorithm for morphologically constrained Gibbs random fields

    NASA Astrophysics Data System (ADS)

    Sivakumar, Krishnamoorthy; Goutsias, John I.

    1998-09-01

    We study the problem of simulating a class of Gibbs random field models, called morphologically constrained Gibbs random fields, using Markov chain Monte Carlo sampling techniques. Traditional single site updating Markov chain Monte Carlo sampling algorithm, like the Metropolis algorithm, tend to converge extremely slowly when used to simulate these models, particularly at low temperatures and for constraints involving large geometrical shapes. Moreover, the morphologically constrained Gibbs random fields are not, in general, Markov. Hence, a Markov chain Monte Carlo sampling algorithm based on the Gibbs sampler is not possible. We prose a variant of the Metropolis algorithm that, at each iteration, allows multi-site updating and converges substantially faster than the traditional single- site updating algorithm. The set of sites that are updated at a particular iteration is specified in terms of a shape parameter and a size parameter. Computation of the acceptance probability involves a 'test ratio,' which requires computation of the ratio of the probabilities of the current and new realizations. Because of the special structure of our energy function, this computation can be done by means of a simple; local iterative procedure. Therefore lack of Markovianity does not impose any additional computational burden for model simulation. The proposed algorithm has been used to simulate a number of image texture models, both synthetic and natural.

  13. User Satisfaction Evaluation of the EHR4CR Query Builder: A Multisite Patient Count Cohort System

    PubMed Central

    Soto-Rey, Iñaki; N'Dja, Aurèle; Cunningham, James; Newe, Axel; Trinczek, Benjamin; Lafitte, Caroline; Sedlmayr, Brita; Fritz, Fleur

    2015-01-01

    The Electronic Health Records for Clinical Research (EHR4CR) project aims to develop services and technology for the leverage reuse of Electronic Health Records with the purpose of improving the efficiency of clinical research processes. A pilot program was implemented to generate evidence of the value of using the EHR4CR platform. The user acceptance of the platform is a key success factor in driving the adoption of the EHR4CR platform; thus, it was decided to evaluate the user satisfaction. In this paper, we present the results of a user satisfaction evaluation for the EHR4CR multisite patient count cohort system. This study examined the ability of testers (n = 22 and n = 16 from 5 countries) to perform three main tasks (around 20 minutes per task), after a 30-minute period of self-training. The System Usability Scale score obtained was 55.83 (SD: 15.37), indicating a moderate user satisfaction. The responses to an additional satisfaction questionnaire were positive about the design of the interface and the required procedure to design a query. Nevertheless, the most complex of the three tasks proposed in this test was rated as difficult, indicating a need to improve the system regarding complicated queries. PMID:26539525

  14. A Multisite Randomized Effectiveness Trial of Motivational Enhancement Therapy for Spanish-Speaking Substance Users

    PubMed Central

    Carroll, Kathleen M.; Martino, Steve; Ball, Samuel A.; Nich, Charla; Frankforter, Tami; Anez, Luis M; Paris, Manuel; Suarez-Morales, Lourdes; Szapocznik, José; Miller, William R.; Rosa, Carmen; Matthews, Julie; Farentinos, Chris

    2009-01-01

    Hispanic individuals are underrepresented in clinical and research populations and often excluded from clinical trials in the US. Hence, there are few data on the effectiveness of most empirically validated therapies for Hispanic substance users. We conducted a multisite randomized trial comparing the effectiveness of three individual sessions of motivational enhancement therapy (MET) to three individual sessions of counseling as usual (CAU) on treatment retention and frequency of substance use, with all assessment and treatment sessions conducted in Spanish among 405 individuals seeking treatment for any type of current substance use. Treatment exposure was good, with 66% of participants completing all three protocol sessions. Although both interventions resulted in reductions in substance use during the 4-week therapy phase, there were no significant treatment condition by time interactions nor site by treatment condition interactions. Results suggest that the individual treatments delivered in Spanish were both attractive to and effective with this heterogeneous group of Hispanic adults, but the differential effectiveness of MET may be limited to those whose primary substance use problem is alcohol and may be fairly modest in magnitude. PMID:19803579

  15. Detection of Intratumor Heterogeneity in Modern Pathology: A Multisite Tumor Sampling Perspective

    PubMed Central

    Cortés, Jesús M.; de Petris, Giovanni; López, José I.

    2017-01-01

    Current sampling protocols of neoplasms along the digestive tract and in the urinary bladder have to be updated, as they do not respond to the necessities of modern personalized medicine. We show here that an adapted version of multisite tumor sampling (MSTS) is a sustainable model to overcome current deficiencies in digestive and bladder tumors when they are large enough so as to make unaffordable a total sampling. The new method is based on the divide-and-conquer algorithm and includes a slight modification of the MSTS, which proved to be useful very recently in clear cell renal cell carcinoma. This in silico analysis confirms the usefulness of MSTS for detecting intratumor heterogeneity (ITH) in tumors arising in hollow viscera. However, MSTS does not seem to improve routine traditional sampling in detecting tumor budding, extramural venous invasion, and perineural invasion. We conclude that (1) MSTS is the best method for tumor sampling to detect ITH balancing high performance and sustainable cost, (2) MSTS must be adapted to tumor shape and tumor location for an optimal performance. PMID:28321395

  16. Risk Factors Associated with HCV among Opioid-dependent Patients in a Multisite Study

    PubMed Central

    Schulte, M.; Hser, Y.; Saxon, A.; Evans, E.; Li, L.; Huang, D.; Hillhouse, M.; Thomas, C.; Ling, W.

    2015-01-01

    We examined risk factors associated with Hepatitis C virus (HCV) infection among opioid-dependent patients enrolled into medication-assisted therapy (buprenorphine or methadone) to determine factors affecting chronic infection. Patients (N=1,039) were randomized as part of a larger, multisite clinical trial sponsored by the National Drug Abuse Treatment Clinical Trials Network assessing liver function. HCV status was first assessed with an antibody screen; if positive, then current infection was determined with an antigen screen testing for detectable virus. Patients were classified as HCV negative, HCV positive but have cleared the virus, or as having chronic HCV. Logistic regression analysis was used to examine demographic and behavioral correlates of the three groups. Thirty-four percent of patients were classified with chronic infection and 14% had evidence of prior infection with apparent clearing of the virus. Chronic infection was associated with recent injection drug use and cocaine use. Chronic HCV infection was also associated with being older and Hispanic. Age, ethnicity, and current drug use increase the likelihood of being chronically infected with HCV. Strategies targeting high risk subgroups can aid in preventing further disease escalation. PMID:25814381

  17. Evolution of translation machinery in recoded bacteria enables multi-site incorporation of nonstandard amino acids

    PubMed Central

    Amiram, Miriam; Haimovich, Adrian D; Fan, Chenguang; Wang, Yane-Shih; Aerni, Hans-Rudolf; Ntai, Ioanna; Moonan, Daniel W; Ma, Natalie J; Rovner, Alexis J; Hong, Seok Hoon; Kelleher, Neil L; Goodman, Andrew L; Jewett, Michael C; Söll, Dieter; Rinehart, Jesse; Isaacs, Farren J

    2016-01-01

    Expansion of the genetic code with nonstandard amino acids (nsAAs) has enabled biosynthesis of proteins with diverse new chemistries. However, this technology has been largely restricted to proteins containing a single or few nsAA instances. Here we describe an in vivo evolution approach in a genomically recoded Escherichia coli strain for the selection of orthogonal translation systems capable of multi-site nsAA incorporation. We evolved chromosomal aminoacyl-tRNA synthetases (aaRSs) with up to 25-fold increased protein production for p-acetyl-L-phenylalanine and p-azido-L-phenylalanine (pAzF). We also evolved aaRSs with tunable specificities for 14 nsAAs, including an enzyme that efficiently charges pAzF while excluding 237 other nsAAs. These variants enabled production of elastin-like-polypeptides with 30 nsAA residues at high yields (~50 mg/L) and high accuracy of incorporation (>95%). This approach to aaRS evolution should accelerate and expand our ability to produce functionalized proteins and sequence-defined polymers with diverse chemistries. PMID:26571098

  18. Evaluation of Speech-Perception Training for Hearing Aid Users: A Multisite Study in Progress.

    PubMed

    Miller, James D; Watson, Charles S; Dubno, Judy R; Leek, Marjorie R

    2015-11-01

    Following an overview of theoretical issues in speech-perception training and of previous efforts to enhance hearing aid use through training, a multisite study, designed to evaluate the efficacy of two types of computerized speech-perception training for adults who use hearing aids, is described. One training method focuses on the identification of 109 syllable constituents (45 onsets, 28 nuclei, and 36 codas) in quiet and in noise, and on the perception of words in sentences presented in various levels of noise. In a second type of training, participants listen to 6- to 7-minute narratives in noise and are asked several questions about each narrative. Two groups of listeners are trained, each using one of these types of training, performed in a laboratory setting. The training for both groups is preceded and followed by a series of speech-perception tests. Subjects listen in a sound field while wearing their hearing aids at their usual settings. The training continues over 15 to 20 visits, with subjects completing at least 30 hours of focused training with one of the two methods. The two types of training are described in detail, together with a summary of other perceptual and cognitive measures obtained from all participants.

  19. A Waveform Library Technique for Multi-Site Identification with the MAJORANA DEMONSTRATOR

    NASA Astrophysics Data System (ADS)

    Buuck, Micah; MAJORANA Collaboration

    2017-01-01

    The MAJORANA DEMONSTRATOR is a low-background array of 44.8 kg of germanium detectors searching for neutrinoless double-beta (0 νββ) decay in germanium-76, deployed 4,850 feet underground at the Sanford Underground Research Facility in Lead, South Dakota, USA. We aim to demonstrate background levels low enough to justify construction of a ton-scale experiment which will be able to fully probe the inverted-hierarchy region of the 0 νββ decay phase-space. In addition to reducing background through materials selection and experimental design, we are developing a range of analysis-based background-suppression techniques. One example is a waveform-library-based technique to reject background multi-site interactions. Here we present an overview of the technique and its current status. This material is based upon work supported by the U.S. Department of Energy, Office of Science, Office of Nuclear Physics, the Particle Astrophysics and Nuclear Physics Programs of the National Science Foundation, and the Sanford Underground Research Facility.

  20. CA3-02: Tools for Quality Multi-site Work with Less Funding

    PubMed Central

    Bachman, Donald; Bauck, Alan; Bardsley, Jeanette; Chen, Ping; Dixon, Art; Luke, Sabrina; Ofstead, Julie; Riedlinger, Karen; Saylor, Gwyn; Staab, Jenny; Pardee, Roy

    2012-01-01

    Background/Aims Since all of the VDW data has been checked, the data must be consistent and perfect. Unfortunately, this isn’t always true. This presentation is designed to introduce project teams and QA work groups to some of the available tools that can be used to efficiently create useful reports to improve and ensure quality. Methods This presentation will discuss some of the tips and tools that are readily available that help project teams and VDW work groups including the following: A standard reporting mechanism to create traffic light (pass/warning/ fail) reports across content areas that sites can review and correct before returning to the coordinating center or lead site (or why data check outcome files are cool). Designing a system where multi-site reports can be efficiently created, updated and reviewed. How CESR QA Macros can help projects Describe the VDW Format Library Program that creates a report that documents the files in your local data warehouse (including the local variables). Results There are many efficient and available tools that improve quality. This presentation gave an update on recent tools the CESR DCC has been working on. Other tools have also been developed by other groups within the HMORN to facilitate HMORN work. Discussion In a tightening funding environment we are all going to need to work more efficiently. These tools give us the opportunity to work better, faster and cheaper.

  1. Predictive beyond-mean-field rate equations for multisite lattice–gas models of catalytic surface reactions: CO oxidation on Pd(100)

    DOE PAGES

    Liu, Da -Jiang; Zahariev, Federico; Gordon, Mark S.; ...

    2016-11-29

    Tailored multisite lattice–gas (msLG) models are developed for CO oxidation on Pd(100) at low-pressures. These models include multiple adsorption site types and superlattice adlayer ordering due to short-range exclusion for highly mobile reactant adspecies. However, they are simplified to neglect longer-range weaker adspecies interactions, so that the key energetic parameters are the CO desorption barrier and the reaction barrier. We discuss existing density functional theory results for these energies and present additional analysis for CO adsorption. After also including an appropriate nontrivial specification of the dynamics of adsorption onto mixed reactant adlayers, we develop rate equations for the reaction kinetics.more » Our formulation goes beyond traditional mean-field (MF) Langmuirian treatments by accounting for multiple adsorption sites and for the strong spatial correlations associated with superlattice ordering. Specifically, we utilize factorization approximations based on appropriate site motifs, and also Padé resummation of exact low-coverage expansions for sticking coefficients. Our beyond-MF rate equations are successful in accurately predicting key aspects of reactive steady-state behavior, and thus expand the utility of rate equation formulations in surface chemistry. This is confirmed by comparison with precise kinetic Monte Carlo simulation results. Furthermore, we not only assess bistability and criticality observed for CO oxidation but also find more complex multistability associated with symmetry-breaking transitions in high-coverage CO adlayers.« less

  2. Predictive beyond-mean-field rate equations for multisite lattice–gas models of catalytic surface reactions: CO oxidation on Pd(100)

    SciTech Connect

    Liu, Da -Jiang; Zahariev, Federico; Gordon, Mark S.; Evans, James W.

    2016-11-29

    Tailored multisite lattice–gas (msLG) models are developed for CO oxidation on Pd(100) at low-pressures. These models include multiple adsorption site types and superlattice adlayer ordering due to short-range exclusion for highly mobile reactant adspecies. However, they are simplified to neglect longer-range weaker adspecies interactions, so that the key energetic parameters are the CO desorption barrier and the reaction barrier. We discuss existing density functional theory results for these energies and present additional analysis for CO adsorption. After also including an appropriate nontrivial specification of the dynamics of adsorption onto mixed reactant adlayers, we develop rate equations for the reaction kinetics. Our formulation goes beyond traditional mean-field (MF) Langmuirian treatments by accounting for multiple adsorption sites and for the strong spatial correlations associated with superlattice ordering. Specifically, we utilize factorization approximations based on appropriate site motifs, and also Padé resummation of exact low-coverage expansions for sticking coefficients. Our beyond-MF rate equations are successful in accurately predicting key aspects of reactive steady-state behavior, and thus expand the utility of rate equation formulations in surface chemistry. This is confirmed by comparison with precise kinetic Monte Carlo simulation results. Furthermore, we not only assess bistability and criticality observed for CO oxidation but also find more complex multistability associated with symmetry-breaking transitions in high-coverage CO adlayers.

  3. Ground-based search for the brightest transiting planets with the Multi-site All-Sky CAmeRA: MASCARA

    NASA Astrophysics Data System (ADS)

    Snellen, Ignas A. G.; Stuik, Remko; Navarro, Ramon; Bettonvil, Felix; Kenworthy, Matthew; de Mooij, Ernst; Otten, Gilles; ter Horst, Rik; le Poole, Rudolf

    2012-09-01

    The Multi-site All-sky CAmeRA MASCARA is an instrument concept consisting of several stations across the globe, with each station containing a battery of low-cost cameras to monitor the near-entire sky at each location. Once all stations have been installed, MASCARA will be able to provide a nearly 24-hr coverage of the complete dark sky, down to magnitude 8, at sub-minute cadence. Its purpose is to find the brightest transiting exoplanet systems, expected in the V=4-8 magnitude range - currently not probed by space- or ground-based surveys. The bright/nearby transiting planet systems, which MASCARA will discover, will be the key targets for detailed planet atmosphere observations. We present studies on the initial design of a MASCARA station, including the camera housing, domes, and computer equipment, and on the photometric stability of low-cost cameras showing that a precision of 0.3-1% per hour can be readily achieved. We plan to roll out the first MASCARA station before the end of 2013. A 5-station MASCARA can within two years discover up to a dozen of the brightest transiting planet systems in the sky.

  4. EPSILON AURIGAE: AN IMPROVED SPECTROSCOPIC ORBITAL SOLUTION

    SciTech Connect

    Stefanik, Robert P.; Torres, Guillermo; Lovegrove, Justin; Latham, David W.; Zajac, Joseph; Pera, Vivian E.; Mazeh, Tsevi

    2010-03-15

    A rare eclipse of the mysterious object {epsilon} Aurigae will occur in 2009-2011. We report an updated single-lined spectroscopic solution for the orbit of the primary star based on 20 years of monitoring at the CfA, combined with historical velocity observations dating back to 1897. There are 518 new CfA observations obtained between 1989 and 2009. Two solutions are presented. One uses the velocities outside the eclipse phases together with mid-times of previous eclipses, from photometry dating back to 1842, which provide the strongest constraint on the ephemeris. This yields a period of 9896.0 {+-} 1.6 days (27.0938 {+-} 0.0044 years) with a velocity semi-amplitude of 13.84 {+-} 0.23 km s{sup -1} and an eccentricity of 0.227 {+-} 0.011. The middle of the current ongoing eclipse predicted by this combined fit is JD 2,455,413.8 {+-} 4.8, corresponding to 2010 August 5. If we use only the radial velocities, we find that the predicted middle of the current eclipse is nine months earlier. This would imply that the gravitating companion is not the same as the eclipsing object. Alternatively, the purely spectroscopic solution may be biased by perturbations in the velocities due to the short-period oscillations of the supergiant.

  5. Spectroscopic Analysis of Planetary Host Stars

    NASA Astrophysics Data System (ADS)

    Rittipruk, P.; Yushchenko, A.; Kang, Y. W.

    2014-08-01

    We observed the high resolution spectra of extra-solar planet host stars. The spectroscopic data of host stars were observed using the CHIRON echelle spectrometer and R-C Spectrograph for magnetic activity on the SMART-1.5 meter telescope at CTIO, Chile. The analysis of spectroscopic data was performed using URAN and SYNTHE programs. These spectra allow us to determine the effective temperatures, surface gravities, microturbulent velocities and, finally, the chemical composition of the hosts was obtained by spectrum synthesis. One of the targets, namely HD 47536, the host of two planets, appeared to be a halo star with overabundances of neutron capture elements. The effective temperature and the surface gravity of this star are 4400 K and log=1.5 respectively, the iron is underabundant by 0.6 dex. The heavy elements (up to thorium, Z=90) show the overabundances with respect to iron. The signs of accretion of interstellar gas are found in the atmosphere of this star.

  6. sick: The Spectroscopic Inference Crank

    NASA Astrophysics Data System (ADS)

    Casey, Andrew R.

    2016-03-01

    There exists an inordinate amount of spectral data in both public and private astronomical archives that remain severely under-utilized. The lack of reliable open-source tools for analyzing large volumes of spectra contributes to this situation, which is poised to worsen as large surveys successively release orders of magnitude more spectra. In this article I introduce sick, the spectroscopic inference crank, a flexible and fast Bayesian tool for inferring astrophysical parameters from spectra. sick is agnostic to the wavelength coverage, resolving power, or general data format, allowing any user to easily construct a generative model for their data, regardless of its source. sick can be used to provide a nearest-neighbor estimate of model parameters, a numerically optimized point estimate, or full Markov Chain Monte Carlo sampling of the posterior probability distributions. This generality empowers any astronomer to capitalize on the plethora of published synthetic and observed spectra, and make precise inferences for a host of astrophysical (and nuisance) quantities. Model intensities can be reliably approximated from existing grids of synthetic or observed spectra using linear multi-dimensional interpolation, or a Cannon-based model. Additional phenomena that transform the data (e.g., redshift, rotational broadening, continuum, spectral resolution) are incorporated as free parameters and can be marginalized away. Outlier pixels (e.g., cosmic rays or poorly modeled regimes) can be treated with a Gaussian mixture model, and a noise model is included to account for systematically underestimated variance. Combining these phenomena into a scalar-justified, quantitative model permits precise inferences with credible uncertainties on noisy data. I describe the common model features, the implementation details, and the default behavior, which is balanced to be suitable for most astronomical applications. Using a forward model on low-resolution, high signal

  7. Spectroscopic Classification of ASASSN-16bx and ASASSN-16cy

    NASA Astrophysics Data System (ADS)

    Frank, S.; Prieto, J. L.; Stanek, K. Z.

    2016-03-01

    We report optical spectroscopic observations of ASASSN-16bx (ATel #8712) and ASASSN-16cy (ATel #8801) obtained by S. Frank on UT 2016 March 14-15 with OSMOS (range 398-686 nm) mounted on the MDM 2.4m telescope at KPNO.

  8. Spectroscopic Classifications of Optical Transients with Mayall/KOSMOS

    NASA Astrophysics Data System (ADS)

    Kilpatrick, C. D.; Pan, Y.-C.; Foley, R. J.; Jha, S. W.; Rest, A.; Scolnic, D.

    2017-01-01

    We report the following classifications of optical transients from spectroscopic observations with KOSMOS on the KPNO Mayall 4-m telescope. Targets were supplied by the All-Sky Automated Survey for Supernovae (ASAS-SN) and the ATLAS project (ATel #8680).

  9. Spectroscopic Classifications of Optical Transients with Mayall/KOSMOS

    NASA Astrophysics Data System (ADS)

    Kilpatrick, C. D.; Pan, Y.-C.; Foley, R. J.; Jha, S. W.; Rest, A.; Scolnic, D.

    2017-02-01

    We report the following classifications of optical transients from spectroscopic observations with KOSMOS on the KPNO Mayall 4-m telescope. Targets were supplied by the All-Sky Automated Survey for Supernovae (ASAS-SN), the ATLAS project (ATel #8680), and the Pan-STARRS Survey for Transients (PSST).

  10. Spectroscopic Classifications of Optical Transients with SOAR/Goodman

    NASA Astrophysics Data System (ADS)

    Miller, J. A.; Hounsell, R. A.; Pan, Y.-C.; Kilpatrick, C. D.; Foley, R. J.; Jha, S. W.; Rest, A.; Scolnic, D.

    2016-08-01

    We report a classification of optical transients from spectroscopic observations with the Goodman spectrograph on the SOAR telescope. Targets were supplied by the All-Sky Automated Survey for Supernovae (ASAS-SN) and the Pan-STARRS Survey for Transients (PSST).

  11. Starfish: Robust spectroscopic inference tools

    NASA Astrophysics Data System (ADS)

    Czekala, Ian; Andrews, Sean M.; Mandel, Kaisey S.; Hogg, David W.; Green, Gregory M.

    2015-05-01

    Starfish is a set of tools used for spectroscopic inference. It robustly determines stellar parameters using high resolution spectral models and uses Markov Chain Monte Carlo (MCMC) to explore the full posterior probability distribution of the stellar parameters. Additional potential applications include other types of spectra, such as unresolved stellar clusters or supernovae spectra.

  12. Spectroscopic constants and potential energy curves for TaH

    NASA Astrophysics Data System (ADS)

    Cheng, W.; Balasubramanian, K.

    1991-09-01

    Spectroscopic constants and potential energy curves of 21 electronic states of the diatomic TaH are computed using complete active space multiconfiguration self-consistent field (CASSCF) followed by second-order configuration interaction (SOCI) calculations. In addition spin-orbit effects were included using the relativistic configuration interaction method (RCI). The ground state of TaH was found to be a 0 + state, which is a mixture of 5Δ(0 +), 5Π(0 +), 3Σ -(0 +), and 3Π(0 +). The spin-orbit effects were found to be significant for TaH. Several spectroscopic transitions are predicted for TaH none of which is observed.

  13. Galaxy And Mass Assembly (GAMA): spectroscopic analysis

    NASA Astrophysics Data System (ADS)

    Hopkins, A. M.; Driver, S. P.; Brough, S.; Owers, M. S.; Bauer, A. E.; Gunawardhana, M. L. P.; Cluver, M. E.; Colless, M.; Foster, C.; Lara-López, M. A.; Roseboom, I.; Sharp, R.; Steele, O.; Thomas, D.; Baldry, I. K.; Brown, M. J. I.; Liske, J.; Norberg, P.; Robotham, A. S. G.; Bamford, S.; Bland-Hawthorn, J.; Drinkwater, M. J.; Loveday, J.; Meyer, M.; Peacock, J. A.; Tuffs, R.; Agius, N.; Alpaslan, M.; Andrae, E.; Cameron, E.; Cole, S.; Ching, J. H. Y.; Christodoulou, L.; Conselice, C.; Croom, S.; Cross, N. J. G.; De Propris, R.; Delhaize, J.; Dunne, L.; Eales, S.; Ellis, S.; Frenk, C. S.; Graham, Alister W.; Grootes, M. W.; Häußler, B.; Heymans, C.; Hill, D.; Hoyle, B.; Hudson, M.; Jarvis, M.; Johansson, J.; Jones, D. H.; van Kampen, E.; Kelvin, L.; Kuijken, K.; López-Sánchez, Á.; Maddox, S.; Madore, B.; Maraston, C.; McNaught-Roberts, T.; Nichol, R. C.; Oliver, S.; Parkinson, H.; Penny, S.; Phillipps, S.; Pimbblet, K. A.; Ponman, T.; Popescu, C. C.; Prescott, M.; Proctor, R.; Sadler, E. M.; Sansom, A. E.; Seibert, M.; Staveley-Smith, L.; Sutherland, W.; Taylor, E.; Van Waerbeke, L.; Vázquez-Mata, J. A.; Warren, S.; Wijesinghe, D. B.; Wild, V.; Wilkins, S.

    2013-04-01

    The Galaxy And Mass Assembly (GAMA) survey is a multiwavelength photometric and spectroscopic survey, using the AAOmega spectrograph on the Anglo-Australian Telescope to obtain spectra for up to ˜300 000 galaxies over 280 deg2, to a limiting magnitude of rpet < 19.8 mag. The target galaxies are distributed over 0 < z ≲ 0.5 with a median redshift of z ≈ 0.2, although the redshift distribution includes a small number of systems, primarily quasars, at higher redshifts, up to and beyond z = 1. The redshift accuracy ranges from σv ≈ 50 km s-1 to σv ≈ 100 km s-1 depending on the signal-to-noise ratio of the spectrum. Here we describe the GAMA spectroscopic reduction and analysis pipeline. We present the steps involved in taking the raw two-dimensional spectroscopic images through to flux-calibrated one-dimensional spectra. The resulting GAMA spectra cover an observed wavelength range of 3750 ≲ λ ≲ 8850 Å at a resolution of R ≈ 1300. The final flux calibration is typically accurate to 10-20 per cent, although the reliability is worse at the extreme wavelength ends, and poorer in the blue than the red. We present details of the measurement of emission and absorption features in the GAMA spectra. These measurements are characterized through a variety of quality control analyses detailing the robustness and reliability of the measurements. We illustrate the quality of the measurements with a brief exploration of elementary emission line properties of the galaxies in the GAMA sample. We demonstrate the luminosity dependence of the Balmer decrement, consistent with previously published results, and explore further how Balmer decrement varies with galaxy mass and redshift. We also investigate the mass and redshift dependencies of the [N II]/Hα versus [O III]/Hβ spectral diagnostic diagram, commonly used to discriminate between star forming and nuclear activity in galaxies.

  14. Spectroscopic evolution of massive stars from unified stellar models

    NASA Astrophysics Data System (ADS)

    Groh, Jose

    2015-08-01

    Our understanding of different classes of massive stars is often built by comparing evolutionary models and observations. However, this comparison is far from trivial, in particular when the effects of mass loss are significant. To tackle this problem, we recently combined stellar evolution calculations using the Geneva code with atmospheric/wind CMFGEN model. This allowed us to determine the interior and spectroscopic evolution of massive stars from the zero-age main sequence (ZAMS) to the pre-supernova (SN) stage. In this talk, I will discuss the spectroscopic evolution stars at solar metallicity, the lifetimes of the different spectroscopic phases (O-type, LBV, WR), how they are related to evolutionary phases (H-core burning, H-shell burning, He-core burning), and their ionizing output. I will also discuss how this is affected by mass loss at different stages of the evolution.

  15. Spectroscopic Orbits for 15 Late-type Stars

    NASA Astrophysics Data System (ADS)

    Willmarth, Daryl W.; Fekel, Francis C.; Abt, Helmut A.; Pourbaix, Dimitri

    2016-08-01

    Spectroscopic orbital elements are determined for 15 stars with periods from 8 to 6528 days with six orbits computed for the first time. Improved astrometric orbits are computed for two stars and one new orbit is derived. Visual orbits were previously determined for four stars, four stars are members of multiple systems, and five stars have Hipparcos “G” designations or have been resolved by speckle interferometry. For the nine binaries with previous spectroscopic orbits, we determine improved or comparable elements. For HD 28271 and HD 200790, our spectroscopic results support the conclusions of previous authors that the large values of their mass functions and lack of detectable secondary spectrum argue for the secondary in each case being a pair of low-mass dwarfs. The orbits given here may be useful in combination with future interferometric and Gaia satellite observations.

  16. Spectroscopic Studies of Melanin.

    DTIC Science & Technology

    1986-01-01

    il), and leading to the production of oxygen radicals (12). Gallas (13) and Kozikowski et al. (14) have studied melanin fluorescence. As part of a...Raman scattering unobservable in aqueous solution by continuous wave techniques. As was also observed by Kozikowski et al. (14), the intrinsic...168B. 14. Kozikowski SD, Wolfram LJ, Alfano RR. Fluorescence spectroscopy of eumelanins. IEEE J Quant Electron 1984;OE20:1379-1382. 15. Slawinski J

  17. Reduced hypothalamic-pituitary-adrenal axis activity in chronic multi-site musculoskeletal pain: partly masked by depressive and anxiety disorders

    PubMed Central

    2014-01-01

    Background Studies on hypothalamic-pituitary-adrenal axis (HPA-axis) function amongst patients with chronic pain show equivocal results and well-controlled cohort studies are rare in this field. The goal of our study was to examine whether HPA-axis dysfunction is associated with the presence and the severity of chronic multi-site musculoskeletal pain. Methods Data are from the Netherlands Study of Depression and Anxiety including 1125 subjects with and without lifetime depressive and anxiety disorders. The Chronic Pain Grade questionnaire was used to determine the presence and severity of chronic multi-site musculoskeletal pain. Subjects were categorized into a chronic multi-site musculoskeletal pain group (n = 471) and a control group (n = 654). Salivary cortisol samples were collected to assess HPA-axis function (awakening level, 1-h awakening response, evening level, diurnal slope and post-dexamethasone level). Results In comparison with the control group, subjects with chronic multi-site musculoskeletal pain showed significantly lower cortisol level at awakening, lower evening level and a blunted diurnal slope. Lower cortisol level at awakening and a blunted diurnal slope appeared to be restricted to those without depressive and/or anxiety disorders, who also showed a lower 1-h awakening response. Conclusions Our results suggest hypocortisolemia in chronic multi-site musculoskeletal pain. However, if chronic pain is accompanied by a depressive or anxiety disorder, typically related to hypercortisolemia, the association between cortisol levels and chronic multi-site musculoskeletal pain appears to be partly masked. Future studies should take psychopathology into account when examining HPA-axis function in chronic pain. PMID:25007969

  18. Planetary atmospheres: Microwave spectroscopic and space physics

    NASA Technical Reports Server (NTRS)

    Clancy, R. Todd

    1990-01-01

    Ground-based spectroscopic observations of isotopes of CO in the atmosphere of Mars, Venus, and Titan were collected over the 1982-1990 period. These observations were analyzed to obtain information on the photochemistry, dynamics, and thermal profiles of these planetary atmospheres. In the cases of the mesosphere (80-100 km altitude) of Venus and the lower atmosphere (0-70 km altitude) of Mars, the primary conclusion of this research is that significant interannual variation in the global, thermal, and compositional structures of these atmospheres occur over 10 year periods. The Titan studies have focussed on pinning down the true atmosphere CO abundance. A more detailed summary of the results for each of these planetary atmospheres is provided.

  19. A multi-site study on medical school selection, performance, motivation and engagement.

    PubMed

    Wouters, A; Croiset, G; Schripsema, N R; Cohen-Schotanus, J; Spaai, G W G; Hulsman, R L; Kusurkar, R A

    2017-05-01

    Medical schools seek ways to improve their admissions strategies, since the available methods prove to be suboptimal for selecting the best and most motivated students. In this multi-site cross-sectional questionnaire study, we examined the value of (different) selection procedures compared to a weighted lottery procedure, which includes direct admission based on top pre-university grade point averages (≥8 out of 10; top-pu-GPA). We also considered whether students had participated in selection, prior to being admitted through weighted lottery. Year-1 (pre-clinical) and Year-4 (clinical) students completed standard validated questionnaires measuring quality of motivation (Academic Self-regulation Questionnaire), strength of motivation (Strength of Motivation for Medical School-Revised) and engagement (Utrecht Work Engagement Scale-Student). Performance data comprised GPA and course credits in Year-1 and clerkship performance in Year-4. Regression analyses were performed. The response rate was 35% (387 Year-1 and 273 Year-4 students). Top-pu-GPA students outperformed selected students. Selected Year-1 students reported higher strength of motivation than top-pu-GPA students. Selected students did not outperform or show better quality of motivation and engagement than lottery-admitted students. Participation in selection was associated with higher engagement and better clerkship performance in Year-4. GPA, course credits and strength of motivation in Year-1 differed between students admitted through different selection procedures. Top-pu-GPA students perform best in the medical study. The few and small differences found raise questions about the added value of an extensive selection procedure compared to a weighted lottery procedure. Findings have to be interpreted with caution because of a low response rate and small group sizes.

  20. Improving pain care through implementation of the Stepped Care Model at a multisite community health center

    PubMed Central

    Anderson, Daren R; Zlateva, Ianita; Coman, Emil N; Khatri, Khushbu; Tian, Terrence; Kerns, Robert D

    2016-01-01

    Purpose Treating pain in primary care is challenging. Primary care providers (PCPs) receive limited training in pain care and express low confidence in their knowledge and ability to manage pain effectively. Models to improve pain outcomes have been developed, but not formally implemented in safety net practices where pain is particularly common. This study evaluated the impact of implementing the Stepped Care Model for Pain Management (SCM-PM) at a large, multisite Federally Qualified Health Center. Methods The Promoting Action on Research Implementation in Health Services framework guided the implementation of the SCM-PM. The multicomponent intervention included: education on pain care, new protocols for pain assessment and management, implementation of an opioid management dashboard, telehealth consultations, and enhanced onsite specialty resources. Participants included 25 PCPs and their patients with chronic pain (3,357 preintervention and 4,385 postintervention) cared for at Community Health Center, Inc. Data were collected from the electronic health record and supplemented by chart reviews. Surveys were administered to PCPs to assess knowledge, attitudes, and confidence. Results Providers’ pain knowledge scores increased to an average of 11% from baseline; self-rated confidence in ability to manage pain also increased. Use of opioid treatment agreements and urine drug screens increased significantly by 27.3% and 22.6%, respectively. Significant improvements were also noted in documentation of pain, pain treatment, and pain follow-up. Referrals to behavioral health providers for patients with pain increased by 5.96% (P=0.009). There was no significant change in opioid prescribing. Conclusion Implementation of the SCM-PM resulted in clinically significant improvements in several quality of pain care outcomes. These findings, if sustained, may translate into improved patient outcomes. PMID:27881926

  1. Crack Growth Prediction Methodology for Multi-Site Damage: Layered Analysis and Growth During Plasticity

    NASA Technical Reports Server (NTRS)

    James, Mark Anthony

    1999-01-01

    A finite element program has been developed to perform quasi-static, elastic-plastic crack growth simulations. The model provides a general framework for mixed-mode I/II elastic-plastic fracture analysis using small strain assumptions and plane stress, plane strain, and axisymmetric finite elements. Cracks are modeled explicitly in the mesh. As the cracks propagate, automatic remeshing algorithms delete the mesh local to the crack tip, extend the crack, and build a new mesh around the new tip. State variable mapping algorithms transfer stresses and displacements from the old mesh to the new mesh. The von Mises material model is implemented in the context of a non-linear Newton solution scheme. The fracture criterion is the critical crack tip opening displacement, and crack direction is predicted by the maximum tensile stress criterion at the crack tip. The implementation can accommodate multiple curving and interacting cracks. An additional fracture algorithm based on nodal release can be used to simulate fracture along a horizontal plane of symmetry. A core of plane strain elements can be used with the nodal release algorithm to simulate the triaxial state of stress near the crack tip. Verification and validation studies compare analysis results with experimental data and published three-dimensional analysis results. Fracture predictions using nodal release for compact tension, middle-crack tension, and multi-site damage test specimens produced accurate results for residual strength and link-up loads. Curving crack predictions using remeshing/mapping were compared with experimental data for an Arcan mixed-mode specimen. Loading angles from 0 degrees to 90 degrees were analyzed. The maximum tensile stress criterion was able to predict the crack direction and path for all loading angles in which the material failed in tension. Residual strength was also accurately predicted for these cases.

  2. Reliability of neuroanatomical measurements in a multisite longitudinal study of youth at risk for psychosis.

    PubMed

    Cannon, Tyrone D; Sun, Frank; McEwen, Sarah Jacobson; Papademetris, Xenophon; He, George; van Erp, Theo G M; Jacobson, Aron; Bearden, Carrie E; Walker, Elaine; Hu, Xiaoping; Zhou, Lei; Seidman, Larry J; Thermenos, Heidi W; Cornblatt, Barbara; Olvet, Doreen M; Perkins, Diana; Belger, Aysenil; Cadenhead, Kristin; Tsuang, Ming; Mirzakhanian, Heline; Addington, Jean; Frayne, Richard; Woods, Scott W; McGlashan, Thomas H; Constable, R Todd; Qiu, Maolin; Mathalon, Daniel H; Thompson, Paul; Toga, Arthur W

    2014-05-01

    Multisite longitudinal neuroimaging designs are used to identify differential brain structural change associated with onset or progression of disease. The reliability of neuroanatomical measurements over time and across sites is a crucial aspect of power in such studies. Prior work has found that while within-site reliabilities of neuroanatomical measurements are excellent, between-site reliability is generally more modest. Factors that may increase between-site reliability include standardization of scanner platform and sequence parameters and correction for between-scanner variations in gradient nonlinearities. Factors that may improve both between- and within-site reliability include use of registration algorithms that account for individual differences in cortical patterning and shape. In this study 8 healthy volunteers were scanned twice on successive days at 8 sites participating in the North American Prodrome Longitudinal Study (NAPLS). All sites employed 3 Tesla scanners and standardized acquisition parameters. Site accounted for 2 to 30% of the total variance in neuroanatomical measurements. However, site-related variations were trivial (<1%) among sites using the same scanner model and 12-channel coil or when correcting for between-scanner differences in gradient nonlinearity and scaling. Adjusting for individual differences in sulcal-gyral geometries yielded measurements with greater reliabilities than those obtained using an automated approach. Neuroimaging can be performed across multiple sites at the same level of reliability as at a single site, achieving within- and between-site reliabilities of 0.95 or greater for gray matter density in the majority of voxels in the prefrontal and temporal cortical surfaces as well as for the volumes of most subcortical structures.

  3. Control of Pteridium aquilinum: Meta-analysis of a Multi-site Study in the UK

    PubMed Central

    Stewart, Gavin; Cox, Emma; Le Duc, Mike; Pakeman, Robin; Pullin, Andrew; Marrs, Rob

    2008-01-01

    Background and Aims A great deal of money is spent controlling invasive weeds as part of international and national policies. It is essential that the funded treatments work across the region in which the policies operate. We argue that experiments across multiple sites are required to validate these programs as results from single sites may be misleading. Here, the control of Pteridium aquilinum (bracken) is used as a test example to address the following four questions. (1) Does the effectiveness of P. aquilinum-control treatments vary across sites? (2) Is the best treatment identified in previous research (cutting twice per year) consistent at all sites, and if not why not? (3) Is treatment performance related to P. aquilinum rhizome mass, litter cover or litter depth at the various sites? (4) Does successful P. aquilinum control influence species richness? Methods Pteridium aquilinum‐control treatments were monitored for 10 years using six replicated experiments and analysed using meta-analysis. Meta-regressions were used to explore heterogeneity between sites. Key Results The effectiveness of treatments varied between sites depending on the measure used to assess P. aquilinum performance. In general, cutting twice per year was the most successful treatment but on some sites other, less expensive treatments were as good. The effectiveness of treatments at different sites was not related to rhizome mass, but the effectiveness of most applied treatments were inversely related to post-control litter. Effective treatment was also associated with high species richness. Conclusions It is concluded that successful development of national weed control programs requires multi-site experimental approaches. Here, meta-analyses demonstrate that variation in effectiveness between sites could be explained in part by pre-specified variables. Reliance on data from a single site for policy formulation is therefore clearly dangerous. PMID:18337356

  4. Multisite Study of an Implanted Continuous Glucose Sensor Over 90 Days in Patients With Diabetes Mellitus

    PubMed Central

    Dehennis, Andrew; Mortellaro, Mark A.; Ioacara, Sorin

    2015-01-01

    Background: Continuous glucose monitoring (CGM), which enables real-time glucose display and trend information as well as real-time alarms, can improve glycemic control and quality of life in patients with diabetes mellitus. Previous reports have described strategies to extend the useable lifetime of a single sensor from 1-2 weeks to 28 days. The present multisite study describes the characterization of a sensing platform achieving 90 days of continuous use for a single, fully implanted sensor. Method: The Senseonics CGM system is composed of a long-term implantable glucose sensor and a wearable smart transmitter. Study subjects underwent subcutaneous implantation of sensors in the upper arm. Eight-hour clinic sessions were performed every 14 days, during which sensor glucose values were compared against venous blood lab reference measurements collected every 15 minutes using mean absolute relative differences (MARDs). Results: All subjects (mean ± standard deviation age: 43.5 ± 11.0 years; with 10 sensors inserted in men and 14 in women) had type 1 diabetes mellitus. Most (22 of 24) sensors reported glucose values for the entire 90 days. The MARD value was 11.4 ± 2.7% (range, 8.1-19.5%) for reference glucose values between 40-400 mg/dl. There was no significant difference in MARD throughout the 90-day study (P = .31). No serious adverse events were noted. Conclusions: The Senseonics CGM, composed of an implantable sensor, external smart transmitter, and smartphone app, is the first system that uses a single sensor for continuous display of accurate glucose values for 3 months. PMID:26224762

  5. Brief interventions to reduce Ecstasy use: a multi-site randomized controlled trial.

    PubMed

    Norberg, Melissa M; Hides, Leanne; Olivier, Jake; Khawar, Laila; McKetin, Rebecca; Copeland, Jan

    2014-11-01

    Studies examining the ability of motivational enhancement therapy (MET) to augment education provision among ecstasy users have produced mixed results and none have examined whether treatment fidelity was related to ecstasy use outcomes. The primary objectives of this multi-site, parallel, two-group randomized controlled trial were to determine if a single-session of MET could instill greater commitment to change and reduce ecstasy use and related problems more so than an education-only intervention and whether MET sessions delivered with higher treatment fidelity are associated with better outcomes. The secondary objective was to assess participants' satisfaction with their assigned interventions. Participants (N=174; Mage=23.62) at two Australian universities were allocated randomly to receive a 15-minute educational session on ecstasy use (n=85) or a 50-minute session of MET that included an educational component (n=89). Primary outcomes were assessed at baseline, and then at 4-, 16-, and 24-weeks postbaseline, while the secondary outcome measure was assessed 4-weeks postbaseline by researchers blind to treatment allocation. Overall, the treatment fidelity was acceptable to good in the MET condition. There were no statistical differences at follow-up between the groups on the primary outcomes of ecstasy use, ecstasy-related problems, and commitment to change. Both intervention groups reported a 50% reduction in their ecstasy use and a 20% reduction in the severity of their ecstasy-related problems at the 24-week follow up. Commitment to change slightly improved for both groups (9%-17%). Despite the lack of between-group statistical differences on primary outcomes, participants who received a single session of MET were slightly more satisfied with their intervention than those who received education only. MI fidelity was not associated with ecstasy use outcomes. Given these findings, future research should focus on examining mechanisms of change. Such work may

  6. Multisite phosphorylation of P-Rex1 by protein kinase C

    PubMed Central

    Montero, Juan Carlos; Seoane, Samuel; García-Alonso, Sara; Pandiella, Atanasio

    2016-01-01

    P-Rex proteins are guanine nucleotide exchange factors (GEFs) that act on the Rho/Rac family of GTP binding proteins. The activity of P-Rex proteins is regulated by several extracellular stimuli. In fact, activation of growth factor receptors has been reported to activate a phosphorylation/dephosphorylation cycle of P-Rex1. Such cycle includes dephosphorylation of serines 313 and 319 which negatively regulate the GEF activity of P-Rex1, together with phosphorylation of serines 605 and 1169 which favour P-Rex1 GEF activity. However, the kinases that regulate phosphorylation at these different regulatory sites are largely unknown. Here we have investigated the potential regulatory action of several kinases on the phosphorylation of P-Rex1 at S313, S319, S605 and S1169. We show that activation of protein kinase C (PKC) caused phosphorylation of S313, S319 and S1169. Activation of growth factor receptors induced phosphorylation of S1169 through a mechanism that was independent of PKC, indicating that distinct kinases and mechanisms control the phosphorylation of P-Rex1 at different regulatory serines. Genetic and biochemical studies confirmed that the PKC isoform PKCδ was able to directly phosphorylate P-Rex1 at S313. Functional studies using cells with very low endogenous P-Rex1 expression, transfected with wild type P-Rex1 or a mutant form in which S313 was substituted by alanine, indicated that phosphorylation at that residue negatively regulated P-Rex1 exchange activity. We suggest that control of P-Rex1 activity depends on a highly dynamic interplay among distinct signalling routes and its multisite phosphorylation is controlled by the action of different kinases. PMID:27788493

  7. Multi-Site Evidence for Marine Nitrogen Fixation in Mid-Cretaceous Black Shales

    NASA Astrophysics Data System (ADS)

    Yum, J.; Meyers, P. A.; Bernasconi, S.

    2004-12-01

    High concentrations of organic carbon in Cretaceous black shales imply levels of sustained export production of organic matter that are unknown in the modern ocean where marine productivity is usually limited by availability of dissolved nitrate. However, if a mid-water anoxic zone expands upward into the photic zone, then nitrogen-fixing cyanobacteria can flourish. These organisms produce organic matter having an isotopic composition close to atmospheric nitrogen (0 per mil). We have compared the carbon and nitrogen isotopic and total organic carbon compositions of Albian to Santonian black shale sequences from the Demerara Rise in the equatorial Atlantic, the Kerguelan Plateau in the southern Indian Ocean, the Hatteras Rise in the western North Atlantic Ocean, the Angola Basin in the eastern South Atlantic Ocean, and the Cape Verde Rise in the eastern North Atlantic Ocean . Nitrogen isotope compositions that become lighter as organic carbon concentrations increase indicate that organic matter production was enhanced by a consortium of primary producers that included nitrogen-fixers. Expansion of an intensified oxygen minimum zone into the photic zone probably permitted coexistence of algae and of cyanobacteria, the latter functioning best under low-oxygen conditions and not being limited by nitrate availability. Improved preservation of the exported organic matter in an intensified near-surface oxygen minimum zone is implied by C/N ratios that increase to 40 as organic carbon concentrations increase. Periods of wetter climate evidently created periods of increased surface stratification of Cretaceous oceans that led to enhanced cyanobacterial primary productivity, magnified organic matter export, and deposition of the organic-carbon-rich black shales. Our multi-site comparison suggests that climate-related gradients in the degree of surface stratification led to associated gradients in export production of organic matter.

  8. Multisite Comparison of High-Sensitivity Multiplex Cytokine Assays▿†

    PubMed Central

    Breen, Elizabeth Crabb; Reynolds, Sandra M.; Cox, Christopher; Jacobson, Lisa P.; Magpantay, Larry; Mulder, Candice B.; Dibben, Oliver; Margolick, Joseph B.; Bream, Jay H.; Sambrano, Elise; Martínez-Maza, Otoniel; Sinclair, Elizabeth; Borrow, Persephone; Landay, Alan L.; Rinaldo, Charles R.; Norris, Philip J.

    2011-01-01

    The concentrations of cytokines in human serum and plasma can provide valuable information about in vivo immune status, but low concentrations often require high-sensitivity assays to permit detection. The recent development of multiplex assays, which can measure multiple cytokines in one small sample, holds great promise, especially for studies in which limited volumes of stored serum or plasma are available. Four high-sensitivity cytokine multiplex assays on a Luminex (Bio-Rad, BioSource, Linco) or electrochemiluminescence (Meso Scale Discovery) platform were evaluated for their ability to detect circulating concentrations of 13 cytokines, as well as for laboratory and lot variability. Assays were performed in six different laboratories utilizing archived serum from HIV-uninfected and -infected subjects from the Multicenter AIDS Cohort Study (MACS) and the Women's Interagency HIV Study (WIHS) and commercial plasma samples spanning initial HIV viremia. In a majority of serum samples, interleukin-6 (IL-6), IL-8, IL-10, and tumor necrosis factor alpha were detectable with at least three kits, while IL-1β was clearly detected with only one kit. No single multiplex panel detected all cytokines, and there were highly significant differences (P < 0.001) between laboratories and/or lots with all kits. Nevertheless, the kits generally detected similar patterns of cytokine perturbation during primary HIV viremia. This multisite comparison suggests that current multiplex assays vary in their ability to measure serum and/or plasma concentrations of cytokines and may not be sufficiently reproducible for repeated determinations over a long-term study or in multiple laboratories but may be useful for longitudinal studies in which relative, rather than absolute, changes in cytokines are important. PMID:21697338

  9. Electronic Cigarette Marketing Online: a Multi-Site, Multi-Product Comparison

    PubMed Central

    Sidhu, Anupreet K; Valente, Thomas W

    2015-01-01

    Background Electronic cigarette awareness and use has been increasing rapidly. E-cigarette brands have utilized social networking sites to promote their products, as the growth of the e-cigarette industry has paralleled that of Web 2.0. These online platforms are cost-effective and have unique technological features and user demographics that can be attractive for selective marketing. The popularity of multiple sites also poses a risk of exposure to social networks where e-cigarette brands might not have a presence. Objective To examine the marketing strategies of leading e-cigarette brands on multiple social networking sites, and to identify how affordances of the digital media are used to their advantage. Secondary analyses include determining if any brands are benefitting from site demographics, and exploring cross-site diffusion of marketing content through multi-site users. Methods We collected data from two e-cigarette brands from four social networking sites over approximately 2.5 years. Content analysis is used to search for themes, population targeting, marketing strategies, and cross-site spread of messages. Results Twitter appeared to be the most frequently used social networking site for interacting directly with product users. Facebook supported informational broadcasts, such as announcements regarding political legislation. E-cigarette brands also differed in their approaches to their users, from informal conversations to direct product marketing. Conclusions E-cigarette makers use different strategies to market their product and engage their users. There was no evidence of direct targeting of vulnerable populations, but the affordances of the different sites are exploited to best broadcast context-specific messages. We developed a viable method to study cross-site diffusion, although additional refinement is needed to account for how different types of digital media are used. PMID:27227129

  10. Spectroscopic Characterization of Microplasmas

    DTIC Science & Technology

    2009-09-20

    solution of electrolyte was used and the discharge phenomenon in bubbles generated by electrolysis using optical emission spectroscopy was studied. The...in bubbles generated by electrolysis using optical emission spectroscopy. We also observed the plasma emission spectrum in the discharge in bubbled...iti on ra te (n m /s ) Frequency (kHz) Si Substrate SiO2/Si Substrate Glass SiO2/Si Si Copper (a) (b) D ep os iti on ra te (n m /s ) 5 mm 25 mm

  11. A multisite study of the effectiveness of methamphetamine treatment: an initiative of the Center for Substance Abuse Treatment.

    PubMed

    Herrell, J M; Taylor, J A; Gallagher, C; Dawud-Noursi, S

    2000-01-01

    In 1998, responding to national and regional epidemiological data indicating that methamphetamine (MA) abuse was a growing problem in the United States, the Center for Substance Abuse Treatment (CSAT) initiated a multisite MA treatment study. Through a collaborative approach among CSAT, seven treatment sites, and a coordinating center, the study compares the clinical and cost effectiveness of a manualized, cognitive-behavioral outpatient treatment developed by the Matrix Center in Los Angeles to the treatment approaches currently employed by the treatment sites. The study also explores technology transfer issues associated with integrating the Matrix approach within existing treatment settings. CSAT's approach to the initiation and management of this type of study is discussed.

  12. Spectroscopic enhancement in nanoparticles embedded glasses

    SciTech Connect

    Sahar, M. R. Ghoshal, S. K.

    2014-09-25

    This presentation provides an overview of the recent progress in the enhancement of the spectroscopic characteristics of the glass embedded with nanoparticles (NPs). Some of our research activities with few significantly new results are highlighted and facilely analyzed. The science and technology dealing with the manipulation of the physical properties of rare earth doped inorganic glasses by embedding metallic NPs or nanoclusters produce the so-called 'nanoglass'. Meanwhile, the spectroscopic enhancement relates the intensity of the luminescence measured at certain transition. The enhancement which expectedly due to the 'plasmonics wave' (referring to the coherent coupling of photons to free electron oscillations called plasmon) occurs at the interface between a conductor and a dielectric. Plasmonics being an emerging concept in advanced optical material of nanophotonics has given this material the ability to exploit the optical response at nanoscale and opened up a new avenue in metal-based glass optics. There is a vast array of plasmonic NPs concepts yet to be explored, with applications spanning solar cells, (bio) sensing, communications, lasers, solid-state lighting, waveguides, imaging, optical data transfer, display and even bio-medicine. Localized surface plasmon resonance (LSPR) can enhance the optical response of nanoglass by orders of magnitude as observed. The luminescence enhancement and surface enhanced Raman scattering (SERS) are new paradigm of research. The enhancement of luminescence due to the influence of metallic NPs is the recurring theme of this paper.

  13. Spectroscopic Instrumentation in Undergraduate Astronomy Laboratories

    NASA Astrophysics Data System (ADS)

    Ludovici, Dominic; Mutel, Robert Lucien; Lang, Cornelia C.

    2017-01-01

    We have designed and built two spectrographs for use in undergraduate astronomy laboratories at the University of Iowa. The first, a low cost (appx. $500) low resolution (R ~ 150 - 300) grating-prism (grism) spectrometer consists of five optical elements and is easily modified to other telescope optics. The grism spectrometer is designed to be used in a modified filter wheel. This type of spectrometer allows students to undertake projects requiring sensitive spectral measurements, such as determining the redshifts of quasars. The second instrument is a high resolution (R ~ 8000), moderate cost (appx. $5000) fiber fed echelle spectrometer. The echelle spectrometer will allow students to conduct Doppler measurements such as those used to study spectroscopic binaries. Both systems are designed to be used with robotic telescope systems. The availability of 3D printing enables both of these spectrographs to be constructed in hands-on instrumentation courses where students build and commission their own instruments. Additionally, these instruments enable introductory majors and non-majors laboratory students to gain experience conducting their own spectroscopic observations.

  14. Spectroscopic investigations of carious tooth decay.

    PubMed

    Thareja, R K; Sharma, A K; Shukla, Shobha

    2008-11-01

    We report on the elemental composition of healthy and infected part of human tooth using laser induced breakdown spectroscopy (LIBS). We have used prominent constituent transitions in laser-excited tooth to diagnose the state of the tooth. A nanosecond laser pulse (355nm, 5ns) was used as an ablating pulse and the sodium (3s2S-3p2P) at 588.99 and (3s2S-3p2P) at 589.99nm, strontium (5s21S-1s5P) at 460.55nm, and calcium (3d3D-4f 3F0) at 452.55nm transitions for spectroscopic analysis. The spectroscopic observations in conjunction with discriminate analysis showed that calcium attached to the hydroxyapatite structure of the tooth was affected severely at the infected part of the tooth. The position-time plots generated from two-dimensional (2D) images conclusively showed a decrease in calcium concentration in the infected region of the irradiated tooth. Using the technique, we could distinguish between the healthy and carious parts of the tooth with significant accuracy.

  15. Spectroscopic enhancement in nanoparticles embedded glasses

    NASA Astrophysics Data System (ADS)

    Sahar, M. R.; Ghoshal, S. K.

    2014-09-01

    This presentation provides an overview of the recent progress in the enhancement of the spectroscopic characteristics of the glass embedded with nanoparticles (NPs). Some of our research activities with few significantly new results are highlighted and facilely analyzed. The science and technology dealing with the manipulation of the physical properties of rare earth doped inorganic glasses by embedding metallic NPs or nanoclusters produce the so-called 'nanoglass'. Meanwhile, the spectroscopic enhancement relates the intensity of the luminescence measured at certain transition. The enhancement which expectedly due to the 'plasmonics wave' (referring to the coherent coupling of photons to free electron oscillations called plasmon) occurs at the interface between a conductor and a dielectric. Plasmonics being an emerging concept in advanced optical material of nanophotonics has given this material the ability to exploit the optical response at nanoscale and opened up a new avenue in metal-based glass optics. There is a vast array of plasmonic NPs concepts yet to be explored, with applications spanning solar cells, (bio) sensing, communications, lasers, solid-state lighting, waveguides, imaging, optical data transfer, display and even bio-medicine. Localized surface plasmon resonance (LSPR) can enhance the optical response of nanoglass by orders of magnitude as observed. The luminescence enhancement and surface enhanced Raman scattering (SERS) are new paradigm of research. The enhancement of luminescence due to the influence of metallic NPs is the recurring theme of this paper.

  16. Spectroscopic characterization of polymers: report

    SciTech Connect

    Koenig, J.L.

    1987-10-01

    Polymer characterization has presented major difficulties to the analytical chemist, who has had to develop techniques to cope with the challenge. Even the elementary problem of measuring molecular weight is not easy. Yet such measurements are essential, because the physical, mechanical, and flow properties depend on the length of the polymer chain. Because of the limited solubility and high viscosity of polymers, many classical techniques have been of little use or have had to be extensively modified to measure the molecular weight of polymers. Size-exclusion chromatographic techniques such as gel permeation have been developed to measure these molecular weight distributions. Special chromatographic instruments with a range of spectroscopic detectors (including infrared and laser-light scattering) have emerged commercially to aid the analytical chemist in the fundamental endeavor to measure the length of the polymer chain and its distribution. The author describes the advantages and disadvantages and disadvantages of various spectroscopic techniques.

  17. The 1997 spectroscopic GEISA databank.

    NASA Astrophysics Data System (ADS)

    Jacquinet-Husson, N.; Arie, E.; Ballard, J.; Barbe, A.; Bjoraker, G.; Bonnet, B.; Brown, L. R.; Camy-Peyret, C.; Champion, J. P.; Chedin, A.; Chursin, A.; Clerbaux, C.; Duxbury, G.; Flaud, J.-M.; Fourrie, N.; Fayt, A.; Graner, G.; Gamache, R.; Goldman, A.; Golovko, V.; Guelachvili, G.; Hartmann, J. M.; Hilico, J. C.; Hillman, J.; Lefevre, G.; Lellouch, E.; Mikhailenko, S. N.; Naumenko, O. V.; Nemtchinov, V.; Newnham, D. A.; Nikitin, A.; Orphal, J.; Perrin, A.; Reuter, D. C.; Rinsland, C. P.; Rosenmann, L.; Rothman, L. S.; Scott, N. A.; Selby, J.; Sinitsa, L. N.; Sirota, J. M.; Smith, A. M.; Smith, K. M.; Tyuterev, V. G.; Tipping, R. H.; Urban, S.; Varanasi, P.; Weber, M.

    1999-05-01

    The current version GEISA-97 of the computer-accessible database system GEISA (Gestion et Etude des Informations Spectroscopiques Atmospheriques: Management and Study of Atmospheric Spectroscopic Information) is described. This catalogue contains 1,346,266 entries. These are the spectroscopic parameters required to describe adequately the individual spectral lines belonging to 42 molecules (96 isotopic species) and located between 0 and 22656 cm-1. The featured molecules are of interest in studies of the terrestrial as well as the other planetary atmospheres, especially those of the giant planets. GEISA-97 contains also a catalog of absorption cross-sections of molecules such as chlorofluorocarbons which exhibit unresolvable spectra. The modifications and improvements made to the earlier edition (GEISA-92) and the data management software are described.

  18. Germanium monochloride (GeCl). Spectroscopic constants and potential energy curves

    NASA Astrophysics Data System (ADS)

    Liao, Dai-Wei; Balasubramanian, K.

    1993-10-01

    The electronic states, potential energy curves and spectroscopic properties of the GeCl radical were calculated by means of the relativistic ab initio complete active space multiconfiguration self-consistent field (CASSCF) followed by first- and second-order configuration interaction (FOCI, SOCI) methods which included up to a million configurations. Our computed spectroscopic constants are in good agreement with the experiment for the observed states. Spectroscopic constants and potential energy curves of several other electronic states are computed which are yet to be observed. We also show that a previous rotational analysis of the B—X system is incorrect.

  19. Spectroscopic classification of ASASSN-16pa as a normal Type Ia supernova

    NASA Astrophysics Data System (ADS)

    Morrell, N.; Phillips, M.; Shappee, Benjamin J.; Dong, Subo

    2016-12-01

    We report on an optical spectroscopic observation of supernova candidate ASASSN-16pa (ATel #9893, AT 2016izf) using the du Pont 2.5-m telescope (+ WFCCD) at Las Campanas Observatory on UT 2016-12-25.04.

  20. Mid-infrared spectroscopic investigation

    NASA Technical Reports Server (NTRS)

    Salisbury, John W.; Vergo, Norma; Walter, Louis

    1987-01-01

    Mid-infrared spectroscopic research efforts are discussed. The development of a new instrumentation to permit advanced measurements in the mid-infrared region of the spectrum, the development of a special library of well-characterized mineral and rock specimens for interpretation of remote sensing data, and cooperative measurements of the spectral signatures of analogues of materials that may be present on the surfaces of asteroids, planets or their Moons are discussed.

  1. Highlights of the Brazilian Solar Spectroscope

    NASA Astrophysics Data System (ADS)

    Sawant, H. S.; Cecatto, J. R.; Mészárosová, H.; Faria, C.; Fernandes, F. C. R.; Karlický, M.; de Andrade, M. C.

    2009-07-01

    The digital, decimetric (950-2500 MHz) Brazilian Solar Spectroscope (BSS, Sawant, H.S., Subramanian, K.R., Faria, C., et al. Brazilian Solar Spectroscope (BSS). Solar Phys. 200, 167-176, 2001) with high time (10-1000 ms) and frequency (1-10 MHz) resolution is in regular operation since April, 1998, at the National Space Research Institute (INPE) at São José dos Campos, Brazil. The BSS has now been upgraded with a new digital data acquisition and data processing system. The new version of the BSS has improved the observational possibilities with the capability to record up to 200 frequency channels available in the selectable frequency range 950-2500 MHz. The GPS receiver permits the acquisition of data with time accuracy in the order of 0.1 ms. The software system of the BSS is composed by two distinct modules: the first, data acquisition system provides a flexible Graphical User Interface (GUI) that allows one to choose the observational parameters. The second module is the real time visualization system that permits real time visualization of the observed dynamic spectrum and additionally allows procedures for visualization and preliminary analysis of the recorded solar spectra. Using the new visualization system, we have realized two new types of dm-radio fine structures: narrow band type III bursts with positive as well as negative group frequency drift and dots emissions arranged in zebra-like and fiber-like chains. Furthermore, we have found flare generated fast wave trains according to their tadpole signature in wavelet power spectra for a decimetric type IV radio event (June 6, 2000 flare).

  2. A Chandra Observation of the Luminous Northeastern Rim of the Galactic Supernova Remnant W28 (G6.4-0.1): Spatially-Resolved Spectroscopic Analysis and Radial Fitting

    NASA Astrophysics Data System (ADS)

    Pannuti, Thomas; Allen, Glenn E.; Mahaffey, Bradley; Poulos, Parker

    2017-01-01

    We present an analysis of a 50 kilosecond observation made with the Chandra X-ray Observatory of the northeastern rim of the Galactic supernova remnant (SNR) W28 (G6.4-0.1). W28 is well-known as the archetypical Galactic mixed-morphology SNR (MMSNRs): MMSNRs are a class of sources that feature a contrasting shell-like radio morphology with a center-filled X-ray morphology. The origin of these contrasting morphologies remains elusive: because MMSNRs all appear to be interacting strongly with ambient molecular clouds, it is suspected that these clouds and these interactions play a prominent role in dictating the appearance of these differing morphologies. The northeastern rim of W28 is particularly remarkable in that it is the only feature of the whole SNR that is detected in X-ray, optical and radio wavelengths: it is also the site of a high number density of hydroxyl (OH) masers which are well-known signposts of interactions between SNRs and molecular clouds. Our observation presented here features the highest angular resolution in X-ray ever attained in the study of this rim. We have performed spatially-resolved X-ray spectroscopy of this rim to search for variations in the spectral properties of individual features. We have also performed radial fitting to the X-ray emission to estimate the volume occupied by the X-ray emitting material.

  3. Structure of a Fbw7-Skp1-Cyclin E Complex: Multisite-Phosphorylated Substrate Recognition by SCF Ubiquitin Ligases

    SciTech Connect

    Hao,B.; Oehlmann, S.; Sowa, M.; Harper, J.; Pavletich, N.

    2007-01-01

    The ubiquitin-mediated proteolysis of cyclin E plays a central role in cell-cycle progression, and cyclin E accumulation is a common event in cancer. Cyclin E degradation is triggered by multisite phosphorylation, which induces binding to the SCFFbw7 ubiquitin ligase complex. Structures of the Skp1-Fbw7 complex bound to cyclin E peptides identify a doubly phosphorylated pThr380/pSer384 cyclin E motif as an optimal, high-affinity degron and a singly phosphorylated pThr62 motif as a low-affinity one. Biochemical data indicate that the closely related yeast SCFCdc4 complex recognizes the multisite phosphorylated Sic1 substrate similarly and identify three doubly phosphorylated Sic1 degrons, each capable of high-affinity interactions with two Cdc4 phosphate binding sites. A model that explains the role of multiple cyclin E/Sic1 degrons is provided by the findings that Fbw7 and Cdc4 dimerize, that Fbw7 dimerization enhances the turnover of a weakly associated cyclin E in vivo, and that Cdc4 dimerization increases the rate and processivity of Sic1 ubiquitination in vitro.

  4. Ten Steps to Conducting a Large, Multi-Site, Longitudinal Investigation of Language and Reading in Young Children

    PubMed Central

    Farquharson, Kelly; Murphy, Kimberly A.

    2016-01-01

    Purpose: This paper describes methodological procedures involving execution of a large-scale, multi-site longitudinal study of language and reading comprehension in young children. Researchers in the Language and Reading Research Consortium (LARRC) developed and implemented these procedures to ensure data integrity across multiple sites, schools, and grades. Specifically, major features of our approach, as well as lessons learned, are summarized in 10 steps essential for successful completion of a large-scale longitudinal investigation in early grades. Method: Over 5 years, children in preschool through third grade were administered a battery of 35 higher- and lower-level language, listening, and reading comprehension measures (RCM). Data were collected from children, their teachers, and their parents/guardians at four sites across the United States. Substantial and rigorous effort was aimed toward maintaining consistency in processes and data management across sites for children, assessors, and staff. Conclusion: With appropriate planning, flexibility, and communication strategies in place, LARRC developed and executed a successful multi-site longitudinal research study that will meet its goal of investigating the contribution and role of language skills in the development of children's listening and reading comprehension. Through dissemination of our design strategies and lessons learned, research teams embarking on similar endeavors can be better equipped to anticipate the challenges. PMID:27064308

  5. Multi-site delamination detection and quantification in composites through guided wave based global-local sensing

    NASA Astrophysics Data System (ADS)

    Tian, Zhenhua; Leckey, Cara; Yu, Lingyu

    2017-02-01

    This paper presents a guided wave based global-local sensing method for rapid detection and quantification of multi-site delamination damage in large composite panels. The global-local approach uses a hybrid system consisting of a piezoelectric transducer (PZT) for generating guided waves and a non-contact scanning laser Doppler vibrometer (SLDV) for acquiring guided wave data. The global-local method is performed in two steps. First, a phased array configured of a small number of SLDV scan points (for example 10×10 points in a rectangular grid array) performs inspection over the entire plate to detect and locate damage. Local areas are identified as potential damage regions for the second step. Then high density wavefield measurements are taken over the identified areas and wavefield analysis is performed to quantitatively evaluate the damage. For the proof of concept in case with multi-site damage, the global-local approach is demonstrated on a carbon fiber reinforced polymer (CFRP) composite plate with two sites of impact-induced delamination damage. In the first step, the locations of two delamination sites are detected by the phased array method. In the second step, the delamination size and shape are evaluated using wavefield analysis. The detected delamination location, size and shape agree well with those of ultrasonic C-scan and the method led to a 93% reduction in inspection time compared to a full SLDV dense grid scan.

  6. Protocol for Acupuncture Treatment of Lateral Elbow Pain: A Multisite Randomised Controlled Trial in China, Hong Kong, Australia, and Italy

    PubMed Central

    Berle, Christine; Li, Wei Hong; Li, Tie; Wang, Fu Chun; Bangrazi, Sergio; Li, Lei; Liguori, Stefano; Liu, Yan Song

    2016-01-01

    Background. Lateral elbow pain is one of the most common musculoskeletal pains associated with the upper limb and has an estimated population incidence of 1–3%. Methods/Design. This study protocol is for a multisite randomised controlled study and is designed to evaluate the clinical efficacy of acupuncture in the treatment of chronic (over three months' duration) lateral elbow pain. Four study sites, in the People's Republic of China, Hong Kong, Italy, and Australia, will recruit 24 participants each. A total of 96 participants will be randomised to either an acupuncture group or a sham laser control group. The primary outcome measure will be the Disabilities of Arm, Shoulder, and Hand questionnaire with secondary outcome measures of Pain-Free Grip Strength Test, Muscle Tension Test, and a pain visual analogue scale. Discussion. Key features for conducting a multisite international acupuncture randomised clinical trial have been detailed in this protocol. Trial Registration. This trial is registered at Australian and New Zealand Clinical Trial Registry ACTRN12613001138774 on 11 October, 2013. PMID:27994627

  7. Mapping Lifetime Brain Volumetry with Covariate-Adjusted Restricted Cubic Spline Regression from Cross-sectional Multi-site MRI.

    PubMed

    Huo, Yuankai; Aboud, Katherine; Kang, Hakmook; Cutting, Laurie E; Landman, Bennett A

    2016-10-01

    Understanding brain volumetry is essential to understand neurodevelopment and disease. Historically, age-related changes have been studied in detail for specific age ranges (e.g., early childhood, teen, young adults, elderly, etc.) or more sparsely sampled for wider considerations of lifetime aging. Recent advancements in data sharing and robust processing have made available considerable quantities of brain images from normal, healthy volunteers. However, existing analysis approaches have had difficulty addressing (1) complex volumetric developments on the large cohort across the life time (e.g., beyond cubic age trends), (2) accounting for confound effects, and (3) maintaining an analysis framework consistent with the general linear model (GLM) approach pervasive in neuroscience. To address these challenges, we propose to use covariate-adjusted restricted cubic spline (C-RCS) regression within a multi-site cross-sectional framework. This model allows for flexible consideration of non-linear age-associated patterns while accounting for traditional covariates and interaction effects. As a demonstration of this approach on lifetime brain aging, we derive normative volumetric trajectories and 95% confidence intervals from 5111 healthy patients from 64 sites while accounting for confounding sex, intracranial volume and field strength effects. The volumetric results are shown to be consistent with traditional studies that have explored more limited age ranges using single-site analyses. This work represents the first integration of C-RCS with neuroimaging and the derivation of structural covariance networks (SCNs) from a large study of multi-site, cross-sectional data.

  8. Quantitative encoding of a partial agonist effect on individual opioid receptors by multi-site phosphorylation and threshold detection

    PubMed Central

    Lau, Elaine K.; Trester-Zedlitz, Michelle; Trinidad, Jonathan C.; Kotowski, Sarah J.; Krutchinsky, Andrew N.; Burlingame, Alma L.; von Zastrow, Mark

    2013-01-01

    Many drugs act as partial agonists of seven-transmembrane signaling receptors when compared to endogenous ligands. Partial agonism is well described as a 'macroscopic' property manifest at the level of physiological systems or cell populations, but it is not known whether partial agonists encode discrete regulatory information at the 'microscopic' level of individual receptors. We addressed this question by focusing on morphine, a partial agonist drug for µ-type opioid peptide receptors, and combining quantitative mass spectrometry with cell biological analysis to investigate morphine's reduced efficacy for promoting receptor endocytosis when compared to a peptide full agonist. We show that these chemically distinct ligands produce a complex, and qualitatively similar mixture of phosphorylated opioid receptor forms in intact cells. Quantitatively, however, the agonists promote markedly disproportional production of multi-site phosphorylation involving a specific Ser/Thr motif, whose modification at more than one residue is essential for efficient recruitment of the adaptor protein β-arrestin to clathrin-coated pits that mediate subsequent endocytosis of MORs. These results reveal quantitative encoding of agonist-selective endocytosis at the level of individual opioid receptors, based on the conserved biochemical principles of multi-site phosphorylation and threshold detection. PMID:21868358

  9. Spectroscopic and physical parameters of Galactic O-type stars. II. Observational constraints on projected rotational and extra broadening velocities as a function of fundamental parameters and stellar evolution

    NASA Astrophysics Data System (ADS)

    Markova, N.; Puls, J.; Simón-Díaz, S.; Herrero, A.; Markov, H.; Langer, N.

    2014-02-01

    Context. Rotation is of key importance for the evolution of massive star, including their fate as supernovae or gamma-ray bursts. However, the rotational velocities of OB stars are difficult to determine. Aims: Based on our own data for 31 Galactic O stars and incorporating similar data for 86 OB supergiants from the literature, we aim at investigating the properties of rotational and extra line-broadening as a function of stellar parameters and at testing model predictions about the evolution of stellar rotation. Methods: Fundamental stellar parameters were determined by means of the code FASTWIND. Projected rotational and extra broadening velocities, vsini and ΘRT, originate from a combined Fourier transform and the goodness-of-fit method. Model calculations published previously were used to estimate the initial evolutionary masses, Mevolinit. Results: The sample O stars with Mevolinit ≳ 50 M⊙ rotate with less that 26% of their break-up velocity, and they also lack slow rotators (vsini ≲ 50 km s-1). For the more massive stars (Mevolinit ≥ 35 M⊙) on the hotter side of the bi-stability jump, the observed and predicted rotational rates agree quite well; for those on the cooler side of the jump, the measured velocties are systematically higher than the predicted ones. In general, the derived ΘRT values decrease toward cooler Teff, whilst for later evolutionary phases they appear, at the same vsini, higher for high-mass stars than for low-mass ones. None of the sample stars shows ΘRT ≥ 110 km s-1. For the majority of the more massive stars, extra broadening either dominates or is in strong competition with rotation. Conclusions: For OB stars of solar metallicity, extra broadening is important and has to be accounted for in the analysis. When appearing at or close to the zero-age main sequence, most of the single and more massive stars rotate slower than previously thought. Model predictions for the evolution of rotation in hot massive stars may need to

  10. The AP spectroscopic binary HD 59435 revisited

    NASA Astrophysics Data System (ADS)

    Wade, G. A.; Mathys, G.; North, P.

    1999-07-01

    HD 59435 is a double-lined spectroscopic binary, one component of which is a magnetic Ap star and the other a G8 or K0 giant (Wade et al. 1996). Both components are very slowly rotating, and the Ap star exhibits spectral lines resolved into their magneti cally-split components. Herein we report additional measurements of the mean magnetic field modulus of the Ap star, measurements of the radial velocities of both components, and Geneva photometry of the system, and discuss their impact upon conclusions drawn previously. Based on observations collected at the European Southern Observatory (La Silla, Chile; ESO Programme Nos. 56.E-0688, 58.E-0159, 60.E-0565). Table 3 is available only in electronic form at the CDS via anonymous ftp 130.79.128.5

  11. Asiago spectroscopic classification of ASASSN-16bp

    NASA Astrophysics Data System (ADS)

    Tomasella, L.; Pastorello, A.; Benetti, S.; Cappellaro, E.; Elias-Rosa, N.; Ochner, P.; Tartaglia, L.; Terreran, G.; Turatto, M.

    2016-02-01

    The Asiago Transient Classification Program (Tomasella et al. 2014, AN, 335, 841) reports the spectroscopic classification of ASASSN-16bp ( = AT 2016adq), discovered by All Sky Automated Survey for SuperNovae ASAS-SN (see Shappee et al. 2014, ApJ, 788, 48 and http://www.astronomy.ohio-state.edu/~assassin/index.shtml ), in CGCG 336-041 (Atel #8666) The observation was performed with the Asiago 1.82 m Copernico Telescope (+AFOSC; range 340-820 nm; resolution 1.4 nm). Name | Discovery UT | Obs. Date UT |z | Type | Phase |Notes ASASSN-16bp | 20160209.61 | 20160211.11 |0.034194 | Ia | ~10d | (1) (1) Also known as SN2016adq in CGCG 336-041 (z=0.034194, d=145 Mpc, via NED).

  12. Spectroscopic Diagnostics of FUors and EXors

    NASA Astrophysics Data System (ADS)

    Liskowsky, Joseph P.; Brittain, S.; Rettig, T.; Simon, T.; Gibb, E.

    2010-01-01

    We present new Keck II NIRSPEC high-spectral resolution 1-5micron spectra of FUor, FUor-like and EXor objects. FUors are young eruptive variables with active accretion disks. The outbursts are thought to be caused by a increase in the stellar accretion rate from 1E-6 Msun/yr to 1E-4Msun/yr and last of order 102 yrs. FUor-like objects share many of the spectroscopic characteristics of FUors, though their outbursts have not been observed. EXors undergo shorter lived outbursts that are much less intense. We present the cross correlation of the NIR spectra of these objects as well as a detailed analysis of ro-vibrational CO fundamental and overtone lines, ro-vibrational H2O, ro-vibrational H2 and Br-gamma lines.

  13. Neutron-spectroscopic strength in Ru isotopes

    SciTech Connect

    Duarte, J.L.M.; Borello-Lewin, T.; Horodynski-Matsushigue, L.B. )

    1994-08-01

    A systematic, high resolution (6--8 keV) study of ([ital d],[ital t]) reactions on [sup 100,102,104]Ru is reported. Spectroscopic factors were extracted by comparison of experimental angular distributions with distorted wave Born approximation predictions. All of the information for [sup 99]Ru and, for excitation energies above 0.9 MeV, for [sup 103]Ru is new. Most of the strength expected for the 50--82 neutron shell was found. The strength distributions are discussed, also in comparison with the corresponding stripping reactions. Special attention is focused on extremely low and relatively intense [ital l]=3 excitations and on the [ital l]=4 transfer pattern observed.

  14. Performance of physician-certified verbal autopsies: multisite validation study using clinical diagnostic gold standards

    PubMed Central

    2011-01-01

    Background Physician review of a verbal autopsy (VA) and completion of a death certificate remains the most widely used approach for VA analysis. This study provides new evidence about the performance of physician-certified verbal autopsy (PCVA) using defined clinical diagnostic criteria as a gold standard for a multisite sample of 12,542 VAs. The study was also designed to analyze issues related to PCVA, such as the impact of a second physician reader on the cause of death assigned, the variation in performance with and without household recall of health care experience (HCE), and the importance of local information for physicians reading VAs. Methods The certification was performed by 24 physicians. The assignment of VA was random and blinded. Each VA was certified by one physician. Half of the VAs were reviewed by a different physician with household recall of health care experience included. The completed death certificate was processed for automated ICD-10 coding of the underlying cause of death. PCVA was compared to gold standard cause of death assignment based on strictly defined clinical diagnostic criteria that are part of the Population Health Metrics Research Consortium (PHMRC) gold standard verbal autopsy study. Results For individual cause assignment, the overall chance-corrected concordance for PCVA against the gold standard cause of death is less than 50%, with substantial variability by cause and physician. Physicians assign the correct cause around 30% of the time without HCE, and addition of HCE improves performance in adults to 45% and slightly higher in children to 48%. Physicians estimate cause-specific mortality fractions (CSMFs) with considerable error for adults, children, and neonates. Only for neonates for a cause list of six causes with HCE is accuracy above 0.7. In all three age groups, CSMF accuracy improves when household recall of health care experience is available. Conclusions Results show that physician coding for cause of death

  15. Random forests for verbal autopsy analysis: multisite validation study using clinical diagnostic gold standards

    PubMed Central

    2011-01-01

    Background Computer-coded verbal autopsy (CCVA) is a promising alternative to the standard approach of physician-certified verbal autopsy (PCVA), because of its high speed, low cost, and reliability. This study introduces a new CCVA technique and validates its performance using defined clinical diagnostic criteria as a gold standard for a multisite sample of 12,542 verbal autopsies (VAs). Methods The Random Forest (RF) Method from machine learning (ML) was adapted to predict cause of death by training random forests to distinguish between each pair of causes, and then combining the results through a novel ranking technique. We assessed quality of the new method at the individual level using chance-corrected concordance and at the population level using cause-specific mortality fraction (CSMF) accuracy as well as linear regression. We also compared the quality of RF to PCVA for all of these metrics. We performed this analysis separately for adult, child, and neonatal VAs. We also assessed the variation in performance with and without household recall of health care experience (HCE). Results For all metrics, for all settings, RF was as good as or better than PCVA, with the exception of a nonsignificantly lower CSMF accuracy for neonates with HCE information. With HCE, the chance-corrected concordance of RF was 3.4 percentage points higher for adults, 3.2 percentage points higher for children, and 1.6 percentage points higher for neonates. The CSMF accuracy was 0.097 higher for adults, 0.097 higher for children, and 0.007 lower for neonates. Without HCE, the chance-corrected concordance of RF was 8.1 percentage points higher than PCVA for adults, 10.2 percentage points higher for children, and 5.9 percentage points higher for neonates. The CSMF accuracy was higher for RF by 0.102 for adults, 0.131 for children, and 0.025 for neonates. Conclusions We found that our RF Method outperformed the PCVA method in terms of chance-corrected concordance and CSMF accuracy for

  16. Simultaneous and sequential multi-site impact response of composite laminates

    NASA Astrophysics Data System (ADS)

    Bartus, Shane D.

    The unique feature in this study was the investigation of the response of polymer composite material to impact by multiple high velocity projectiles. Energy absorption, new surface creation, and failure mechanisms from both sequential and near-simultaneous multi-site, high velocity impact were compared to assess synergistic and cumulative effects. A single-stage light-gas gun capable of launching three projectiles with controlled impact location and velocity in both near-simultaneous and sequential impact modes was developed to study these effects. Two test programs were conducted to evaluate these impact scenarios on thin S-2 glass/epoxy laminates. In the first program, the effect of laminate thickness was investigated using .30 caliber steel spherical projectiles. The material response near and above the ballistic limit at constant incident velocity was studied with respect to two and three projectile impacts. It was found that specimens subjected to sequential impact absorbed 10.1% more impact energy and exhibited increases of 23.0% (two projectile) and 10.5% (three projectile) in delamination damage over specimens subjected to simultaneous impact. The second test program involved a study assessing projectile mass effects for .50 caliber spherical Al 2O3 (3.94 g), steel (8.38 g), and tungsten carbide (16.08 g) projectiles at constant incident energy. A factor of four increase in projectile mass corresponded to 22.4% (sequential impact) and 12.8% (simultaneous impact) increases in delamination damage. Energy absorption increased 11.9% (sequential impact) and 8.7% simultaneous impact for laminates subjected to tungsten carbide projectiles over Al2O3 projectiles. Energy absorption in laminates subjected to sequential impact was 20.0% higher (average) than those impacted simultaneously. In contrast to the .30 caliber impact study, delamination damage increased 14.6% (average) for specimens subjected to simultaneous impact. In both studies, impact energy absorption

  17. Acrylonitrile is a multisite carcinogen in male and female B6C3F1 mice.

    PubMed

    Ghanayem, Burhan I; Nyska, Abraham; Haseman, Joseph K; Bucher, John R

    2002-07-01

    Acrylonitrile is a heavily produced unsaturated nitrile, which is used in the production of synthetic fibers, plastics, resins, and rubber. Acrylonitrile is a multisite carcinogen in rats after exposure via gavage, drinking water, or inhalation. No carcinogenicity studies of acrylonitrile in a second animal species were available. The current studies were designed to assess the carcinogenicity of acrylonitrile in B6C3F1 mice of both sexes. Acrylonitrile was administered by gavage at 0, 2.5, 10, or 20 mg/kg/day, 5 days per week, for 2 years. Urinary thiocyanate and N-acetyl-S-(2-cyanoethyl)-L-cysteine were measured as markers of exposure to acrylonitrile. In general, there were dose-related increases in urinary thiocyanate and N-acetyl-S-(2-cyanoethyl)-L-cysteine concentrations in all dosed groups of mice and at all time points. Survival was significantly (p < 0.001) reduced in the top dose (20 mg/kg) group of male and female mice relative to controls. The incidence of forestomach papillomas and carcinomas was increased in mice of both sexes in association with an increase in forestomach epithelial hyperplasia. The incidence of Harderian gland adenomas and carcinomas was also markedly increased in the acrylonitrile-dosed groups. In female mice, the incidence of benign or malignant granulosa cell tumors (combined) in the ovary in the 10 mg/kg dose group was greater than that in the vehicle control group, but because of a lack of dose response, this was considered an equivocal finding. In addition, the incidences of atrophy and cysts in the ovary of the 10 and 20 mg/kg dose groups were significantly increased. The incidences of alveolar/bronchiolar adenoma or carcinoma (combined) were significantly increased in female mice treated with acrylonitrile at 10 mg/kg/day for 2 years. This was also considered an equivocal result. In conclusion, these studies demonstrated that acrylonitrile causes multiple carcinogenic effects after gavage administration to male and female B6

  18. The Setting-up of Multi-Site School Collaboratives: The Benefits of This Organizational Reform in Terms of Networking Opportunities and Their Effects

    ERIC Educational Resources Information Center

    Mifsud, Denise

    2015-01-01

    This article, which is set within the Maltese education scenario of unfolding decentralization through the setting-up of multi-site school collaboratives (legally termed "colleges") via a policy mandate, explores a particular aspect of this reform--that of "networking". This is examined in terms of the potential for…

  19. WWC Review of the Report "Transfer Incentives for High-Performing Teachers: Final Results from a Multisite Randomized Experiment." What Works Clearinghouse Single Study Review

    ERIC Educational Resources Information Center

    What Works Clearinghouse, 2015

    2015-01-01

    For the 2013 study, "Transfer Incentives for High-Performing Teachers: Final Results from a Multisite Randomized Experiment," researchers examined the impact of the Talent Transfer Initiative (TTI) on students' reading and mathematics achievement in 10 school districts. The TTI enabled principals of low-performing schools to provide…

  20. Measurement characteristics of activity-related psychosocial measures in 8- to 10-year-old African-American girls in the Girls health Enrichment Multisite Study (GEMS)

    Technology Transfer Automated Retrieval System (TEKTRAN)

    BACKGROUND: This paper presents reliability and validity analyses of physical activity-related psychosocial questionnaires completed by 8- to 10-year-old African-American girls at baseline and follow-up assessments of pilot intervention studies in the Girls health Enrichment Multi-site Study (GEMS)....

  1. The Study to Explore Early Development (SEED): A Multisite Epidemiologic Study of Autism by the Centers for Autism and Developmental Disabilities Research and Epidemiology (CADDRE) Network

    ERIC Educational Resources Information Center

    Schendel, Diana E.; DiGuiseppi, Carolyn; Croen, Lisa A.; Fallin, M. Daniele; Reed, Philip L.; Schieve, Laura A.; Wiggins, Lisa D.; Daniels, Julie; Grether, Judith; Levy, Susan E.; Miller, Lisa; Newschaffer, Craig; Pinto-Martin, Jennifer; Robinson, Cordelia; Windham, Gayle C.; Alexander, Aimee; Aylsworth, Arthur S.; Bernal, Pilar; Bonner, Joseph D.; Blaskey, Lisa; Bradley, Chyrise; Collins, Jack; Ferretti, Casara J.; Farzadegan, Homayoon; Giarelli, Ellen; Harvey, Marques; Hepburn, Susan; Herr, Matthew; Kaparich, Kristina; Landa, Rebecca; Lee, Li-Ching; Levenseller, Brooke; Meyerer, Stacey; Rahbar, Mohammad H.; Ratchford, Andria; Reynolds, Ann; Rosenberg, Steven; Rusyniak, Julie; Shapira, Stuart K.; Smith, Karen; Souders, Margaret; Thompson, Patrick Aaron; Young, Lisa; Yeargin-Allsopp, Marshalyn

    2012-01-01

    The Study to Explore Early Development (SEED), a multisite investigation addressing knowledge gaps in autism phenotype and etiology, aims to: (1) characterize the autism behavioral phenotype and associated developmental, medical, and behavioral conditions and (2) investigate genetic and environmental risks with emphasis on immunologic, hormonal,…

  2. Sources of Site Differences in the Efficacy of a Multisite Clinical Trial: The Treatment of SSRI-Resistant Depression in Adolescents

    ERIC Educational Resources Information Center

    Spirito, Anthony; Abebe, Kaleab Z.; Iyengar, Satish; Brent, David; Vitiello, Benedetto; Clarke, Gregory; Wagner, Karen Dineen; Asarnow, Joan; Emslie, Graham; Keller, Martin

    2009-01-01

    Site differences in treatment outcomes are not often highlighted when the results of multisite randomized clinical trials (MRCTs) are reported. The primary analyses of a 6-site MRCT, the Treatment of SSRI-Resistant Depression in Adolescents (TORDIA) study, showed substantial variation by site in the performance of a medication-only condition and a…

  3. Sensitivity of the Modified Children's Yale-Brown Obsessive Compulsive Scale to Detect Change: Results from Two Multi-Site Trials

    ERIC Educational Resources Information Center

    Scahill, Lawrence; Sukhodolsky, Denis G.; Anderberg, Emily; Dimitropoulos, Anastasia; Dziura, James; Aman, Michael G.; McCracken, James; Tierney, Elaine; Hallett, Victoria; Katz, Karol; Vitiello, Benedetto; McDougle, Christopher

    2016-01-01

    Repetitive behavior is a core feature of autism spectrum disorder. We used 8-week data from two federally funded, multi-site, randomized trials with risperidone conducted by the Research Units on Pediatric Psychopharmacology Autism Network to evaluate the sensitivity of the Children's Yale-Brown Obsessive Compulsive Scale modified for autism…

  4. The Challenges and Benefits of Employing a Mobile Research Fellow to Facilitate Team Work on a Large, Interdisciplinary, Multi-Sited Project

    ERIC Educational Resources Information Center

    Sugden, Fraser; Punch, Samantha

    2014-01-01

    Over the last few years research funding has increasingly moved in favour of large, multi-partner, interdisciplinary and multi-site research projects. This article explores the benefits and challenges of employing a full-time research fellow to work across multiple field sites, with all the local research teams, on an international,…

  5. The Development of a Strategic Plan To Provide a Multisite Electronic Engineering Technology Program at the Community College of Allegheny County.

    ERIC Educational Resources Information Center

    Cunningham, Pearly

    A project was undertaken to develop a strategic plan to implement a multisite electronic engineering technology (EET) program at Pennsylvania's Community College of Allegheny County. Specifically, the project sought to determine how electronic communication technologies could provide a virtual learning community for the program; appropriate plans…

  6. The GEISA Spectroscopic Database System in its latest Edition

    NASA Astrophysics Data System (ADS)

    Jacquinet-Husson, N.; Crépeau, L.; Capelle, V.; Scott, N. A.; Armante, R.; Chédin, A.

    2009-04-01

    GEISA (Gestion et Etude des Informations Spectroscopiques Atmosphériques: Management and Study of Spectroscopic Information)[1] is a computer-accessible spectroscopic database system, designed to facilitate accurate forward planetary radiative transfer calculations using a line-by-line and layer-by-layer approach. It was initiated in 1976. Currently, GEISA is involved in activities related to the assessment of the capabilities of IASI (Infrared Atmospheric Sounding Interferometer on board the METOP European satellite -http://earth-sciences.cnes.fr/IASI/)) through the GEISA/IASI database[2] derived from GEISA. Since the Metop (http://www.eumetsat.int) launch (October 19th 2006), GEISA/IASI is the reference spectroscopic database for the validation of the level-1 IASI data, using the 4A radiative transfer model[3] (4A/LMD http://ara.lmd.polytechnique.fr; 4A/OP co-developed by LMD and Noveltis with the support of CNES). Also, GEISA is involved in planetary research, i.e.: modelling of Titan's atmosphere, in the comparison with observations performed by Voyager: http://voyager.jpl.nasa.gov/, or by ground-based telescopes, and by the instruments on board the Cassini-Huygens mission: http://www.esa.int/SPECIALS/Cassini-Huygens/index.html. The updated 2008 edition of GEISA (GEISA-08), a system comprising three independent sub-databases devoted, respectively, to line transition parameters, infrared and ultraviolet/visible absorption cross-sections, microphysical and optical properties of atmospheric aerosols, will be described. Spectroscopic parameters quality requirement will be discussed in the context of comparisons between observed or simulated Earth's and other planetary atmosphere spectra. GEISA is implemented on the CNES/CNRS Ether Products and Services Centre WEB site (http://ether.ipsl.jussieu.fr), where all archived spectroscopic data can be handled through general and user friendly associated management software facilities. More than 350 researchers are

  7. Spectroscopic signature for ferroelectric ice

    NASA Astrophysics Data System (ADS)

    Wójcik, Marek J.; Gług, Maciej; Boczar, Marek; Boda, Łukasz

    2014-09-01

    Various forms of ice exist within our galaxy. Particularly intriguing type of ice - ‘ferroelectric ice' was discovered experimentally and is stable in temperatures below 72 K. This form of ice can generate enormous electric fields and can play an important role in planetary formation. In this letter we present Car-Parrinello simulation of infrared spectra of ferroelectric ice and compare them with spectra of hexagonal ice. Librational region of the spectra can be treated as spectroscopic signature of ice XI and can be of help to identify ferroelectric ice in the Universe.

  8. Spectroscopic properties of chlorophyll f.

    PubMed

    Li, Yaqiong; Cai, Zheng-Li; Chen, Min

    2013-09-26

    The absorption and fluorescence spectra of chlorophyll f (newly discovered in 2010) have been measured in acetone and methanol at different temperatures. The spectral analysis and assignment are compared with the spectra of chlorophyll a and d under the same experimental conditions. The spectroscopic properties of these chlorophylls have further been studied by the aid of density functional CAM-B3LYP and high-level symmetric adapted coupled-cluster configuration interaction calculations. The main Q and Soret bands and possible sidebands of chlorophylls have been determined. The photophysical properties of chlorophyll f are discussed.

  9. Violence and non-violence-related injuries and alcohol in women from developed and developing countries: a multi-site emergency room study.

    PubMed

    da Silva, Rosiane Lopes; Diehl, Alessandra; Cherpitel, Cheryl J; Figlie, Neliana B

    2015-02-01

    This study sought to analyze the association between alcohol consumption and the occurrence of injuries in women attending the emergency room (ER) from developing and developed countries. The sample consisted of ER data from women in 15 countries that were collected as part of two multi-site studies using similar methodologies: the Emergency Room Collaborative Alcohol Analysis Project (ERCAAP), and World Health Organization Collaborative Study on Alcohol and Injuries (WHO Study). Women ranged in age from 18 to 98years. Those from developed countries had higher levels of education (43% completed high-school) than women from developing countries (37%). Over half of the women from developing countries reported they had not consumed alcohol in the last 12months (abstentious), while 2% reported drinking every day. In addition, current drinking women from developing countries reported more binge drinking episodes (33% reported 5 to 11 drinks and 15% reported 12 or more drinks on an occasion) compared to those from developed countries (28% and 11%, respectively). Violence-related injury was more prevalent in developing countries (18%) compared to developed countries (9%). An association between injury and the frequency of alcohol consumption in the last 12months was observed in both developing and developed countries. Although women from developing countries who suffered violence-related injuries were more likely to demonstrate alcohol abstinence or have lower rates of daily alcohol consumption, these women drank in a more dangerous way, and violence-related injuries were more likely to occur in these women than in those living in developed countries.

  10. Biological Stress Systems, Adverse Life Events, and the Improvement of Chronic Multisite Musculoskeletal Pain Across a 6-Year Follow-Up.

    PubMed

    Generaal, Ellen; Vogelzangs, Nicole; Macfarlane, Gary J; Geenen, Rinie; Smit, Johannes H; de Geus, Eco J C N; Dekker, Joost; Penninx, Brenda W J H

    2017-02-01

    Dysfunction of biological stress systems and adverse life events, independently and in interaction, have been hypothesized to predict chronic pain persistence. Conversely, these factors may hamper the improvement of chronic pain. Longitudinal evidence is currently lacking. We examined whether: 1) function of biological stress systems, 2) adverse life events, and 3) their combination predict the improvement of chronic multisite musculoskeletal pain. Subjects of the Netherlands Study of Depression and Anxiety (NESDA) with chronic multisite musculoskeletal pain at baseline (N = 665) were followed-up 2, 4, and 6 years later. The Chronic Pain Grade Questionnaire was used to determine improvement (not meeting the criteria) of chronic multisite musculoskeletal pain at follow-up. Baseline assessment of biological stress systems included function of hypothalamic-pituitary-adrenal axis (1-hour cortisol awakening response, evening level, and post dexamethasone level), the immune system (basal and lipopolysaccharide-stimulated inflammatory markers), the autonomic nervous system (heart rate, pre-ejection period, SD of the normal-to-normal interval, and respiratory sinus arrhythmia). The number of adverse life events were assessed at baseline and 2-year follow-up using the List of Threatening Events Questionnaire. We showed that hypothalamic-pituitary-adrenal axis, immune system, and autonomic nervous system functioning and adverse life events were not associated with the improvement of chronic multisite musculoskeletal pain, either as a main effect or in interaction. This longitudinal study could not confirm that biological stress system dysfunction and adverse life events affect the course of chronic multisite musculoskeletal pain.

  11. Radio Spectroscopic Imaging of Electron Beams in the Solar Corona

    NASA Astrophysics Data System (ADS)

    Bastian, Timothy S.; Chen, B.

    2012-05-01

    The recently upgraded Jansky Very Large Array was used to observe the radio emission from a C class solar flare. Observations were performed from 1-2 GHz with a spectral resolution of 1 MHz and time resolution of 100 ms. A number of fast-drift, type-III-like radio bursts was observed, the result of nonthermal electron beams propagating from the flare site, guided by the coronal magnetic field. Using these dynamic, imaging, spectroscopic observations, the electron beam trajectories are deduced.Implications are briefly discussed.

  12. Revealing the ISM in high redshift starburst galaxies: An analysis of Herschel PACS and SPIRE FTS spectroscopic observations of HerMES and H-ATLAS-selected lensed galaxies

    NASA Astrophysics Data System (ADS)

    Cooray, Asantha

    In the quest to develop a fundamental understanding of galaxy formation and evolution, observations of dusty star-forming galaxies (DSFGs) promise significant progress this decade. The importance of DSFGs is highlighted by the fact that half of the energy emitted by extragalactic sources emerges as dust-reprocessed light at infrared (IR) to sub millimeter wavelength. In the post-herschel\\ era, we are now at a unique position to tackle some of the key questions on galaxy formation and evolution because of the large area Herschel's Key Project surveys (HerMES and H-ATLAS). In particular those surveys have allowed us to identify a sample of 250 strongly gravitationally lensed DSFGs at z > 1. They give us a unique opportunity to dissect the detailed structures and kinematics of DSFGs. The Herschel Science Archive also contains individual follow up data on 44 and 25 of the brightest sources with SPIRE-FTS and PACS, respectively, in the spectroscopy mode, taking over 250 hours in four open-time programs. Only one of the 44 SPIRE FTS targets has yet to appear in the published literature. One of the four include an open-time 2 PACS spectroscopy program that was led at UCI by a former postdoc from the PI's group. That program was initially approved at Priority 2 in 2011, but was triggered in late 2012 and achieved 100% completion during the last two weeks of Herschel lifetime in May 2013. This archival analysis, interpretation, and modeling program involves two parts: (i) PACS spectroscopy in 50 to 200 microns of 25 lensed galaxies in the fine-structure emission lines [SiII]34, [SIII]33, [OIV]26, [OIII]52, [NIII]57 and [OI]63, and the molecular hydrogen H_2 S(0) and S(1). (ii) SPIRE FTS spectroscopy of 44 lensed galaxies, including above 25, over the wavelength range of 200 to 600 microns targeting [CII]158, [OIII]88, [OI]63/145, and [NI]122. The analysis will lead to a better understanding of the ISM of starbursting galaxies that span 1 < z < 3.1 range in redshift and a

  13. Neutron-Proton Asymmetry Dependence of Spectroscopic Factors in Ar Isotopes

    SciTech Connect

    Lee, Jenny; Tsang, Betty; Shapira, Dan

    2010-01-01

    Spectroscopic factors have been extracted for proton-rich 34Ar and neutron-rich 46Ar using the (p, d) neutron transfer reaction. The experimental results show little reduction of the ground state neutron spectroscopic factor of the proton-rich nucleus 34Ar compared to that of 46Ar. The results suggest that correlations, which generally reduce such spectroscopic factors, do not depend strongly on the neutron-proton asymmetry of the nucleus in this isotopic region as was reported in knockout reactions. The present results are consistent with results from systematic studies of transfer reactions but inconsistent with the trends observed in knockout reaction measurements.

  14. SPECTROSCOPIC BINARIES IN THE ORION NEBULA CLUSTER AND NGC 2264

    SciTech Connect

    Kounkel, Marina; Hartmann, Lee; Mateo, Mario; Bailey, John I. III; Spencer, Meghin; Tobin, John J.

    2016-04-10

    We examine the spectroscopic binary population for two massive nearby regions of clustered star formation, the Orion Nebula Cluster (ONC) and NGC 2264, supplementing the data presented by Tobin et al. with more recent observations and more extensive analysis. The inferred multiplicity fraction up to 10 au based on these observations is 5.3 ± 1.2% for NGC 2264 and 5.8 ± 1.1% for the ONC; these values are consistent with the distribution of binaries in the field in the relevant parameter range. Eight of the multiple systems in the sample have enough epochs to perform an initial fit for the orbital parameters. Two of these sources are double-lined spectroscopic binaries; for them, we determine the mass ratio. Our reanalysis of the distribution of stellar radial velocities toward these clusters presents a significantly better agreement between stellar and gas kinematics than was previously thought.

  15. Spectroscopic Constants and Potential Energy Curves of PbI

    NASA Astrophysics Data System (ADS)

    Benavidesgarcia, M.; Balasubramanian, K.

    1993-10-01

    The spectroscopic constants and potential energy curves of the PbI diatomic were computed using complete active space SCF (CASSCF) followed by first-order CI (FOCI) and second-order CI (SOCI) calculations which included 607 000 configurations. Spin-orbit coupling was studied using the relativistic CI (RCI) method. The spectroscopic properties of the 2Π1/2 state are Re = 2.885 Å, ωe, = 153 cm-1, and De = 2.54(eV), while for the 2Π3/2 state the corresponding values are Re = 2.859 Å, ωe = 162 cm-1, and Te = 8255 cm-1. Our computed constants are in good agreement with experiment for the observed states. We also computed the properties and curves for several excited states which are yet to be observed.

  16. Spectroscopic imaging in electron microscopy

    SciTech Connect

    Pennycook, Stephen J; Colliex, C.

    2012-01-01

    In the scanning transmission electron microscope, multiple signals can be simultaneously collected, including the transmitted and scattered electron signals (bright field and annular dark field or Z-contrast images), along with spectroscopic signals such as inelastically scattered electrons and emitted photons. In the last few years, the successful development of aberration correctors for the electron microscope has transformed the field of electron microscopy, opening up new possibilities for correlating structure to functionality. Aberration correction not only allows for enhanced structural resolution with incident probes into the sub-angstrom range, but can also provide greater probe currents to facilitate mapping of intrinsically weak spectroscopic signals at the nanoscale or even the atomic level. In this issue of MRS Bulletin, we illustrate the power of the new generation of electron microscopes with a combination of imaging and spectroscopy. We show the mapping of elemental distributions at atomic resolution and also the mapping of electronic and optical properties at unprecedented spatial resolution, with applications ranging from graphene to plasmonic nanostructures, and oxide interfaces to biology.

  17. Spectroscopic insight for tablet compression.

    PubMed

    Lakio, S; Ylinärä, H; Antikainen, O; Räikkönen, H; Yliruusi, J

    2015-02-01

    Tablet compression process has been studied over the years from various perspectives. However what exactly happens to material during compression is still unknown. In this study a novel compression die which enables real-time spectroscopic measurements during the compression of material is represented. Both near infrared and Raman spectroscope probes can be attached to the die. In this study the usage of the die is demonstrated by using Raman spectroscopy. Eicosane, d-glucose anhydrate, α-lactose monohydrate and xylitol were used in the study because their compression behavior and bonding properties during compression were assumed to be different. The intensity of the Raman signal changed during compression with all of the materials. However, the intensity changes were different within the materials. The biggest differences were within the xylitol spectra. It was noticed that some peaks disappeared with higher compression pressures indicating that the pressure affected variously on different bonds in xylitol structure. These reversible changes were supposed to relate the changes in conformation and crystal structure. As a conclusion, the die was found to be a significant addition for studying compression process in real-time. It can help to reveal Process induced transformations (PITs) occurring during powder compaction.

  18. Spectroscopic Classification of PSN J14324449+0953123

    NASA Astrophysics Data System (ADS)

    Valenti, S.; Sand, D.; Parrent, J. T.; Graham, M. L.; Howell, D. A.

    2013-02-01

    We report spectroscopic observation of PSN J14324449+0953123 (listed on the IAU Central Bureau's TOCP page). A spectrum (range 350-1000 nm) obtained robotically on Feb. 18.70 UT with the FLOYDS (FTS) spectrograph shows it to be a young type-II supernova. The spectrum shows a blue continuum with a broad feature at ~ 4600A. The Balmer lines are not visible. Comparisons with a library of supernova spectra using the "GELATO" code (Harutyunyan et al.

  19. Spectroscopic, Kinetic, and Dynamic Experiments on Atmospheric Species.

    DTIC Science & Technology

    1985-03-21

    0077 PHYSICAL SCIENCES RESEARCH PAPERS , NO. 668 P D-A 162 691 Spectroscopic, Kinetic, and Dynamic Experiments on Atmospheric Species S. M. MILLER J. I...we observed, in a very limited data base , values similar to those predicted by the theory of Billingsley4 over the range 4 ! v’ :- 12. This result is...the identities of several others. Further investigations will be aided by an improved data base under conditions similar to those in Figure 9, with

  20. Spectroscopic Studies of Nearby Cool Stars: The DUNES Sample

    NASA Astrophysics Data System (ADS)

    Maldonado, J.; Martínez-Arnáiz, R. M.; Eiroa, C.; Montes, D.

    2009-02-01

    At the Universities of Madrid we are carrying out a systematic analysis of the spectroscopic properties of the nearby (d<25 pc), late-type stellar population with the aim of contributing to the knowledge of the stellar formation history in the solar neighbourhood. Part of our sample will be observed by DUNES, a Herschel OTKP aiming at detecting and studying cold, faint dust disks around nearby stars. In this contribution we present some preliminary results of the kinematics of the DUNES sample.

  1. Spectroscopic Studies of Nearby Cool Stars: The DUNES Sample

    NASA Astrophysics Data System (ADS)

    Maldonado, J.; Martinez-Arnáiz, R. M.; Eiroa, C.; Montes, D.

    At the universities of Madrid we are carrying out a systematic analysis of the spectroscopic properties of the nearby (d<25pc), late-type stellar population with the aim of contributing to the knowledge of the stellar formation history in the solar neighbourhood. Part of our sample will be observed by DUNES, a Herschel OTKP aiming at detecting and studying cold, faint dust disks around nearby stars. In this contribution we present some preliminary results on the kinematics of the DUNES sample.

  2. Kinetics and spectroscopic observations of atrazine dealkylation on manganese oxides

    SciTech Connect

    Malengreau, N.; Sposito, G.; Cheney, M.A.; Crowley, D.E.

    1997-12-31

    Abiotic transformations of organic pollutants are often neglected in remediation scenarios but nonetheless can contribute significantly to detoxification. Mn oxide minerals are capable of degrading organic pollutants adsorbed to their surfaces by both redox and proton-promoted mechanisms. Concurrently with calorimetric, gas-pressure, chromatographic, and ESR methods, we used ICP, DRS, DRIFT, and FTIR spectroscopies to investigate atrazine degradation on three Mn oxides. We found that N-dealkylation can occur abiotically, leading to the formation of deethylatrazine and deisopropylatrazine. The Mn extractability after degradation of atrazine was highly dependent on the Mn oxide. Extractable Mn increased with time for cryptomelane, was constant for pyrolusite, and remained very low for birnessite. The extractable Mn is Mn(II). UV signatures of atrazine by-products were different from one another and were used to trace degradation products at the Mn oxide surface. Mechanistic interpretation of the in situ reaction kinetics and thermodynamics will be discussed.

  3. Spectroscopic Needs for Imaging Dark Energy Experiments

    SciTech Connect

    Newman, Jeffrey A.; Slosar, Anze; Abate, Alexandra; Abdalla, Filipe B.; Allam, Sahar; Allen, Steven W.; Ansari, Reza; Bailey, Stephen; Barkhouse, Wayne A.; Beers, Timothy C.; Blanton, Michael R.; Brodwin, Mark; Brownstein, Joel R.; Brunner, Robert J.; Carrasco-Kind, Matias; Cervantes-Cota, Jorge; Chisari, Nora Elisa; Colless, Matthew; Comparat, Johan; Coupon, Jean; Cheu, Elliott; Cunha, Carlos E.; de la Macorra, Alex; Dell’Antonio, Ian P.; Frye, Brenda L.; Gawiser, Eric J.; Gehrels, Neil; Grady, Kevin; Hagen, Alex; Hall, Patrick B.; Hearin, Andrew P.; Hildebrandt, Hendrik; Hirata, Christopher M.; Ho, Shirley; Honscheid, Klaus; Huterer, Dragan; Ivezic, Zeljko; Kneib, Jean -Paul; Kruk, Jeffrey W.; Lahav, Ofer; Mandelbaum, Rachel; Marshall, Jennifer L.; Matthews, Daniel J.; Menard, Brice; Miquel, Ramon; Moniez, Marc; Moos, H. W.; Moustakas, John; Papovich, Casey; Peacock, John A.; Park, Changbom; Rhodes, Jason; Sadeh, Iftach; Schmidt, Samuel J.; Stern, Daniel K.; Tyson, J. Anthony; von der Linden, Anja; Wechsler, Risa H.; Wood-Vasey, W. M.; Zentner, A.

    2015-03-15

    Ongoing and near-future imaging-based dark energy experiments are critically dependent upon photometric redshifts (a.k.a. photo-z’s): i.e., estimates of the redshifts of objects based only on flux information obtained through broad filters. Higher-quality, lower-scatter photo-z’s will result in smaller random errors on cosmological parameters; while systematic errors in photometric redshift estimates, if not constrained, may dominate all other uncertainties from these experiments. The desired optimization and calibration is dependent upon spectroscopic measurements for secure redshift information; this is the key application of galaxy spectroscopy for imaging-based dark energy experiments. Hence, to achieve their full potential, imaging-based experiments will require large sets of objects with spectroscopically-determined redshifts, for two purposes: Training: Objects with known redshift are needed to map out the relationship between object color and z (or, equivalently, to determine empirically-calibrated templates describing the rest-frame spectra of the full range of galaxies, which may be used to predict the color-z relation). The ultimate goal of training is to minimize each moment of the distribution of differences between photometric redshift estimates and the true redshifts of objects, making the relationship between them as tight as possible. The larger and more complete our “training set” of spectroscopic redshifts is, the smaller the RMS photo-z errors should be, increasing the constraining power of imaging experiments; Requirements: Spectroscopic redshift measurements for ~30,000 objects over >~15 widely-separated regions, each at least ~20 arcmin in diameter, and reaching the faintest objects used in a given experiment, will likely be necessary if photometric redshifts are to be trained and calibrated with conventional techniques. Larger, more complete samples (i.e., with longer exposure times) can improve photo-z algorithms and reduce scatter

  4. Spectroscopic Needs for Imaging Dark Energy Experiments

    DOE PAGES

    Newman, Jeffrey A.; Slosar, Anze; Abate, Alexandra; ...

    2015-03-15

    Ongoing and near-future imaging-based dark energy experiments are critically dependent upon photometric redshifts (a.k.a. photo-z’s): i.e., estimates of the redshifts of objects based only on flux information obtained through broad filters. Higher-quality, lower-scatter photo-z’s will result in smaller random errors on cosmological parameters; while systematic errors in photometric redshift estimates, if not constrained, may dominate all other uncertainties from these experiments. The desired optimization and calibration is dependent upon spectroscopic measurements for secure redshift information; this is the key application of galaxy spectroscopy for imaging-based dark energy experiments. Hence, to achieve their full potential, imaging-based experiments will require large setsmore » of objects with spectroscopically-determined redshifts, for two purposes: Training: Objects with known redshift are needed to map out the relationship between object color and z (or, equivalently, to determine empirically-calibrated templates describing the rest-frame spectra of the full range of galaxies, which may be used to predict the color-z relation). The ultimate goal of training is to minimize each moment of the distribution of differences between photometric redshift estimates and the true redshifts of objects, making the relationship between them as tight as possible. The larger and more complete our “training set” of spectroscopic redshifts is, the smaller the RMS photo-z errors should be, increasing the constraining power of imaging experiments; Requirements: Spectroscopic redshift measurements for ~30,000 objects over >~15 widely-separated regions, each at least ~20 arcmin in diameter, and reaching the faintest objects used in a given experiment, will likely be necessary if photometric redshifts are to be trained and calibrated with conventional techniques. Larger, more complete samples (i.e., with longer exposure times) can improve photo-z algorithms and reduce

  5. Obstetrical and neonatal outcomes of methadone-maintained pregnant women: a canadian multisite cohort study.

    PubMed

    Ordean, Alice; Kahan, Meldon; Graves, Lisa; Abrahams, Ron; Kim, Theresa

    2015-03-01

    Objectif : Décrire les issues obstétricales et néonatales, y compris le syndrome d’abstinence néonatal (SAN), au sein d’une cohorte canadienne de femmes enceintes recevant un traitement de substitution à la méthadone. Méthodes : Nous avons mené une analyse de dossiers rétrospective au sein de trois programmes de soins intégrés à Vancouver, à Toronto et à Montréal. Les femmes enceintes recevant un traitement de substitution à la méthadone (TSM) qui ont sollicité les services de ces programmes entre 1997 et 2009 ont été admises à cette étude multisite. Les issues maternelles et néonatales constatées au sein de chacun des centres participants ont été comparées. Résultats : En tout, 94 femmes enceintes recevant un traitement de substitution à la méthadone ont été admises à l’analyse finale : 36 de Toronto, 36 de Vancouver et 22 de Montréal. Les caractéristiques démographiques maternelles ont révélé la présence de différences entre les programmes en matière d’ethnicité et d’état matrimonial. Les complications obstétricales n’ont pas été fréquentes : la plus fréquente a été l’hémorragie prénatale, laquelle a été constatée chez 14 % des femmes de la cohorte entière. L’incidence du travail prématuré était considérablement plus élevée à Vancouver et à Montréal qu’à Toronto. Pour l’ensemble de la cohorte, l’âge gestationnel moyen au moment de l’accouchement a été de 38 semaines; le poids denaissance moyen a été de 2 856 grammes. La durée moyenne de l’hospitalisation des nouveau-nés présentant un SAN a été de 19 jours, 27 % d’entre eux ayant nécessité une pharmacothérapie pour contrer le SAN. Environ 60 % des nouveau-nés ont été remis à leur mère à la suite de l’obtention de leur congé de l’hôpital. Conclusion : Les programmes de soins intégrés ont permis l’obtention d’issues obstétricales et néonatales satisfaisantes chez les femmes

  6. A MultiSite Gateway Toolkit for Rapid Cloning of Vertebrate Expression Constructs with Diverse Research Applications

    PubMed Central

    Fowler, Daniel K.; Stewart, Scott; Seredick, Steve; Eisen, Judith S.

    2016-01-01

    Recombination-based cloning is a quick and efficient way to generate expression vectors. Recent advancements have provided powerful recombinant DNA methods for molecular manipulations. Here, we describe a novel collection of three-fragment MultiSite Gateway cloning system-compatible vectors providing expanded molecular tools for vertebrate research. The components of this toolkit encompass a broad range of uses such as fluorescent imaging, dual gene expression, RNA interference, tandem affinity purification, chemically-inducible dimerization and lentiviral production. We demonstrate examples highlighting the utility of this toolkit for producing multi-component vertebrate expression vectors with diverse primary research applications. The vectors presented here are compatible with other Gateway toolkits and collections, facilitating the rapid generation of a broad range of innovative DNA constructs for biological research. PMID:27500400

  7. Long-term, multisite, parallel, in-cell recording and stimulation by an array of extracellular microelectrodes.

    PubMed

    Hai, Aviad; Shappir, Joseph; Spira, Micha E

    2010-07-01

    Here we report on the development of a novel neuroelectronic interface consisting of an array of noninvasive gold-mushroom-shaped microelectrodes (gMmicroEs) that practically provide intracellular recordings and stimulation of many individual neurons, while the electrodes maintain an extracellular position. The development of this interface allows simultaneous, multisite, long-term recordings of action potentials and subthreshold potentials with matching quality and signal-to-noise ratio of conventional intracellular sharp glass microelectrodes or patch electrodes. We refer to the novel approach as "in-cell recording and stimulation by extracellular electrodes" to differentiate it from the classical intracellular recording and stimulation methods. This novel technique is expected to revolutionize the analysis of neuronal networks in relations to learning, information storage and can be used to develop novel drugs as well as high fidelity neural prosthetics and brain-machine systems.

  8. Completion Report for Multi-Site Incentive MRT 2779 Implement ASC Tripod Initiative by 30SEP08

    SciTech Connect

    East, D; Cerutti, J; Noe, J; Cupps, K; Loncaric, J; Sturtevant, J

    2008-09-22

    This report provides documentation and evidence for the completion of the deployment of the Tripod common operating system (TripodOS, also known as and generally referred to below as TOSS). Background documents for TOSS are provided in Appendices A and B, including the initial TOSS proposal accepted by ASC HQ and Executives in July 2007 and a Governance Model defined by a Tri-Lab working group in September 2007. Appendix C contains a document that clarifies the intent and requirements for the completion criteria associated with MRT 2779. The deployment of TOSS is a Multi-Site Incentive from the ASC FY08-09 Implementation Plan due at the end of Quarter 4 in FY08.

  9. Promotoras de Salud: Roles, Responsibilities, and Contributions in a Multi-Site Community-Based Randomized Controlled Trial

    PubMed Central

    Hilfinger Messias, DeAnne K.; Parra-Medina, Deborah; Sharpe, Patricia A.; Treviño, Laura; Koskan, Alexis M.; Morales-Campos, Daisy

    2013-01-01

    There is widespread recognition of the cultural and linguistic appropriateness of promotoras de salud (a Spanish term for community health workers) in health education and outreach among Hispanic communities. Yet there are significant gaps in the literature regarding the preparation, implementation and evaluation of promotoras’ engagement in research. To address this gap, we examine promotoras’ research-related training, roles, responsibilities, and contributions in a community-based participatory research project involving a multi-site randomized controlled trial of a physical activity intervention for Mexican-origin women in Texas and South Carolina. We identify both benefits and challenges associated with promotoras’ engagement as community researchers; examine variations and differences in promotora roles and responsibilities related to the research contexts, sites, settings, and individual characteristics; and discuss implications for research and practice. PMID:24695944

  10. Development of a Multi-Site and Multi-Device Webgis-Based Tool for Tidal Current Energy Development

    NASA Astrophysics Data System (ADS)

    Ang, M. R. C. O.; Panganiban, I. K.; Mamador, C. C.; De Luna, O. D. G.; Bausas, M. D.; Cruz, J. P.

    2016-06-01

    A multi-site, multi-device and multi-criteria decision support tool designed to support the development of tidal current energy in the Philippines was developed. Its platform is based on Geographic Information Systems (GIS) which allows for the collection, storage, processing, analyses and display of geospatial data. Combining GIS tools with open source web development applications, it becomes a webGIS-based marine spatial planning tool. To date, the webGIS-based tool displays output maps and graphs of power and energy density, site suitability and site-device analysis. It enables stakeholders and the public easy access to the results of tidal current energy resource assessments and site suitability analyses. Results of the initial development showed that it is a promising decision support tool for ocean renewable energy project developments.

  11. Spectroscopic problems in ITER diagnostics

    NASA Astrophysics Data System (ADS)

    Lisitsa, V. S.; Bureyeva, L. A.; Kukushkin, A. B.; Kadomtsev, M. B.; Krupin, V. A.; Levashova, M. G.; Medvedev, A. A.; Mukhin, E. E.; Shurygin, V. A.; Tugarinov, S. N.; Vukolov, K. Yu

    2012-12-01

    Problems of spectroscopic diagnostics of ITER plasma are under consideration. Three types of diagnostics are presented: 1) Balmer lines spectroscopy in the edge and divertor plasmas; 2) Thomson scattering, 3) charge exchange recombination spectroscopy. The Zeeman-Stark structure of line shapes is discussed. The overlapping of isotopes H-D-T spectral line shapes are presented for the SOL and divertor conditions. The polarization measurements of H-alpha spectral lines for H-D mixture on T-10 tokamak are shown in order to separate Zeeman splitting in more details. The problem of plasma background radiation emission for Thomson scattering in ITER is discussed in details. The line shape of P-7 hydrogen spectral line having a wave length close to laser one is presented together with continuum radiation. The charge exchange recombination spectroscopy (CXRS) is discussed in details. The data on Dα, HeII and CVI measurements in CXRS experiments on T-10 tokamak are presented.

  12. The Hubble Spectroscopic Legacy Archive

    NASA Astrophysics Data System (ADS)

    Peeples, Molly S.; Tumlinson, Jason; Fox, Andrew; Aloisi, Alessandra; Ayres, Thomas R.; Danforth, Charles; Fleming, Scott W.; Jenkins, Edward B.; Jedrzejewski, Robert I.; Keeney, Brian A.; Oliveira, Cristina M.

    2016-01-01

    With no future space ultraviolet instruments currently planned, the data from the UV spectrographs aboard the Hubble Space Telescope have a legacy value beyond their initial science goals. The Hubble Spectroscopic Legacy Archive will provide to the community new science-grade combined spectra for all publicly available data obtained by the Cosmic Origins Spectrograph (COS) and the Space Telescope Imaging Spectrograph (STIS). These data will be packaged into "smart archives" according to target type and scientific themes to facilitate the construction of archival samples for common science uses. A new "quick look" capability will make the data easy for users to quickly access, assess the quality of, and download for archival science starting in Cycle 24, with the first generation of these products for the FUV modes of COS available online via MAST in early 2016.

  13. Spectroscopic Studies of Abell Clusters

    NASA Astrophysics Data System (ADS)

    Way, Michael Joseph

    The objectives of this work are to use spectroscopic techniques to accurately categorize galaxies as either HII region star forming galaxies or as Active Galactic Nuclei powered via a black hole, and to use radial velocities and projected positions of galaxies in clusters to obtain the total cluster mass and its distribution. The masses and distributions compare well to X-ray mass measurements. The commonly used Dressler, A., Thompson, I. & Shectman, S. 1985, ApJ, 288, 481 technique for discriminating between Active Galactic Nuclei and HII region galaxies uses the measurement of the equivalent width of the emission lines (OII) 3727 A, H/beta, and (OIII) 5007 A. High quality spectra from 42 galaxies were taken and it is shown that their method is not capable of distinguishing between Active Galactic Nuclei and HII region galaxies. The emission line flux from H/beta, (OIII) 5007 A, (OI) 6300 A, Hα, (NII) 6583 A, and (SII) 6716+6731 A in combination with the method of Veilleux, S. & Osterbrock, D. E. 1987, ApJS, 63, 295 must be used to accurately distinguish between Active Galactic Nuclei and HII region galaxies. Galaxy radial velocities from spectroscopic data and their projected 2-D positions in clusters are used to obtain robust estimates of the total mass and mass distribution in two clusters. The total mass is calculated using the Virial theorem after removing substructure. The mass distribution is estimated via several robust statistical tests for 1-D, 2-D and 3-D structure. It is shown that the derived mass estimates agree well with those found independently from hot X-ray gas emission in clusters.

  14. SPECTROSCOPIC SUBSYSTEMS IN NEARBY WIDE BINARIES

    SciTech Connect

    Tokovinin, Andrei

    2015-12-15

    Radial velocity (RV) monitoring of solar-type visual binaries has been conducted at the CTIO/SMARTS 1.5 m telescope to study short-period systems. The data reduction is described, and mean and individual RVs of 163 observed objects are given. New spectroscopic binaries are discovered or suspected in 17 objects, and for some of them the orbital periods could be determined. Subsystems are efficiently detected even in a single observation by double lines and/or by the RV difference between the components of visual binaries. The potential of this detection technique is quantified by simulation and used for statistical assessment of 96 wide binaries within 67 pc. It is found that 43 binaries contain at least one subsystem, and the occurrence of subsystems is equally probable in either primary or secondary components. The frequency of subsystems and their periods matches the simple prescription proposed by the author. The remaining 53 simple wide binaries with a median projected separation of 1300 AU have an RV difference distribution between their components that is not compatible with the thermal eccentricity distribution f (e) = 2e but rather matches the uniform eccentricity distribution.

  15. Optimization of spectroscopic surveys for testing non-Gaussianity

    SciTech Connect

    Raccanelli, Alvise; Doré, Olivier; Dalal, Neal E-mail: Olivier.P.Dore@jpl.nasa.gov

    2015-08-01

    We investigate optimization strategies to measure primordial non-Gaussianity with future spectroscopic surveys. We forecast measurements coming from the 3D galaxy power spectrum and compute constraints on primordial non-Gaussianity parameters f{sub NL} and n{sub NG}. After studying the dependence on those parameters upon survey specifications such as redshift range, area, number density, we assume a reference mock survey and investigate the trade-off between number density and area surveyed. We then define the observational requirements to reach the detection of f{sub NL} of order 1. Our results show that power spectrum constraints on non-Gaussianity from future spectroscopic surveys can improve on current CMB limits, but the multi-tracer technique and higher order correlations will be needed in order to reach an even better precision in the measurements of the non-Gaussianity parameter f{sub NL}.

  16. Spectroscopic and Interferometric Measurements of Nine K Giant Stars

    NASA Astrophysics Data System (ADS)

    Baines, Ellyn K.; Döllinger, Michaela P.; Guenther, Eike W.; Hatzes, Artie P.; Hrudkovu, Marie; van Belle, Gerard T.

    2016-09-01

    We present spectroscopic and interferometric measurements for a sample of nine K giant stars. These targets are of particular interest because they are slated for stellar oscillation observations. Our improved parameters will directly translate into reduced errors in the final masses for these stars when interferometric radii and asteroseismic densities are combined. Here, we determine each star’s limb-darkened angular diameter, physical radius, luminosity, bolometric flux, effective temperature, surface gravity, metallicity, and mass. When we compare our interferometric and spectroscopic results, we find no systematic offsets in the diameters and the values generally agree within the errors. Our interferometric temperatures for seven of the nine stars are hotter than those determined from spectroscopy with an average difference of about 380 K.

  17. Evaluating transdiagnostic treatment for distress and impairment in veterans: a multi-site randomized controlled trial of Acceptance and Commitment Therapy.

    PubMed

    Lang, Ariel J; Schnurr, Paula P; Jain, Sonia; Raman, Rema; Walser, Robyn; Bolton, Elisa; Chabot, Aimee; Benedek, David

    2012-01-01

    Military personnel who engaged in the conflicts in Afghanistan and Iraq frequently present for mental health care because of the stresses of service and readjustment. Although excellent treatments are available to treat the typical presenting problems, there is a need for additional empirically supported treatment approaches for this population. Because these veterans have high levels of comorbidity, transdiagnostic treatment - treatment that applies to more than one diagnosis - may be an efficient approach for this group. Acceptance and Commitment Therapy (ACT) is one such approach that is well-known and has high face validity for veterans, but it has not been rigorously evaluated as a treatment for trauma-related mental health problems. Described herein is an ongoing multi-site randomized clinical trial of ACT as compared to a psychotherapy control. Challenges in designing an RCT to evaluate transdiagnostic treatment and in executing a multi-site psychotherapy trial are discussed.

  18. Post Admission Cognitive Therapy (PACT) for the Inpatient Treatment of Military Personnel with Suicidal Behaviors: A Multi-Site Randomized Controlled Trial

    DTIC Science & Technology

    2013-02-01

    depression, trauma, sleep , suicide ideation), repeat number of psychiatric hospitalization(s), hope for one’s future, and acceptability of treatment (as...0106 TITLE: Post Admission Cognitive Therapy (PACT) for the Inpatient Treatment of Military Personnel with Suicidal Behaviors: A Multi- Site...Inpatient Treatment of Military Personnel with Suicidal Behaviors: A Multi-Site Randomized Controlled Trial Service Members and Veterans 5a

  19. Nonlocal thermal transport in solar flares. II - Spectroscopic diagnostics

    NASA Technical Reports Server (NTRS)

    Karpen, Judith T.; Cheng, Chung-Chieh; Doschek, George A.; Devore, C. Richard

    1989-01-01

    Physical parameters obtained for a flaring solar atmosphere in an earlier paper are used here to predict time-dependent emission-line profiles and integrated intensities as a function of position for two spectral lines commonly observed during solar flares: the X-ray resonance lines of Ca XIX and Mg XI. Considerations of ionization nonequilibrium during the rise phase of the flare are addressed, and the effects on the predicted spectral-line characteristics are discussed. It is concluded that some spectroscopic diagnostics favor the nonlocal model, but other long-standing discrepancies between the numerical models and the observations remain unresolved.

  20. Spectroscopic study of the extremely fast rotating star 44 Geminorum

    NASA Astrophysics Data System (ADS)

    Iliev, L.; Vennes, S.; Kawka, A.; Kubat, J.; Nemeth, P.; Borisov, G.; KRaus, M.

    Stars with extremely fast rotation represent interesting challenge to modern understanding of the stellar evolution. The reasons why such a spin-up process should occur during the evolution to otherwise normal star are still not well understood. Already in the beginning of the XX century Otto Struve proposed that fast rotation of the group of stars spectroscopically classified as Be could be the main reason for the formation of observed disks of circumstellar material around them. This circumstellar material is responsible for the emission lines observed in the spectrum of Be-stars as well as for the whole complex of spectral and photometrical patterns called in general Be-phenomenon.