PS2-06: Best Practices for Advancing Multi-site Chart Abstraction Research

PubMed Central

Blick, Noelle; Cole, Deanna; King, Colleen; Riordan, Rick; Von Worley, Ann; Yarbro, Patty

2012-01-01

Background/Aims Multi-site chart abstraction studies are becoming increasingly common within the HMORN. Differences in systems among HMORN sites can pose significant obstacles to the success of these studies. It is therefore crucial to standardize abstraction activities by following best practices for multi-site chart abstraction, as consistency of processes across sites will increase efficiencies and enhance data quality. Methods Over the past few months the authors have been meeting to identify obstacles to multi-site chart abstraction and to address ways in which multi-site chart abstraction processes can be systemized and standardized. The aim of this workgroup is to create a best practice guide for multi-site chart abstraction studies. Focus areas include: abstractor training, format for chart abstraction (database, paper, etc), data quality, redaction, mechanism for transferring data, site specific access to medical records, IRB/HIPAA concerns, and budgetary issues. Results The results of the workgroup’s efforts (the best practice guide) will be presented by a panel of experts at the 2012 HMORN conference. The presentation format will also focus on discussion among attendees to elicit further input and to identify areas that need to be further addressed. Subsequently, the best practice guide will be posted on the HMORN website. Discussion The best practice guide for multi-site chart abstraction studies will establish sound guidelines and serve as an aid to researchers embarking on multi-site chart abstraction studies. Efficiencies and data quality will be further enhanced with standardized multi-site chart abstraction practices.

Spectroscopic pulsational frequency identification and mode determination of γ Doradus star HD 12901

NASA Astrophysics Data System (ADS)

Brunsden, E.; Pollard, K. R.; Cottrell, P. L.; Wright, D. J.; De Cat, P.

2012-12-01

Using multisite spectroscopic data collected from three sites, the frequencies and pulsational modes of the γ Doradus star HD 12901 were identified. A total of six frequencies in the range 1-2 d-1 were observed, their identifications supported by multiple line-profile measurement techniques and previously published photometry. Five frequencies were of sufficient signal-to-noise ratio for mode identification, and all five displayed similar three-bump standard deviation profiles which were fitted well with (l,m) = (1,1) modes. These fits had reduced χ2 values of less than 18. We propose that this star is an excellent candidate to test models of non-radially pulsating γ Doradus stars as a result of the presence of multiple (1,1) modes. This paper includes data taken at the Mount John University Observatory of the University of Canterbury (New Zealand), the McDonald Observatory of the University of Texas at Austin (Texas, USA) and the European Southern Observatory at La Silla (Chile).

Observations of the Magnetic Cataclysmic Variable VV Puppis with the Far Ultraviolet Spectroscopic Explorer

NASA Astrophysics Data System (ADS)

Hoard, D. W.; Szkody, Paula; Ishioka, Ryoko; Ferrario, L.; Gänsicke, B. T.; Schmidt, Gary D.; Kato, Taichi; Uemura, Makoto

2002-10-01

We present the first far-ultraviolet (FUV) observations of the magnetic cataclysmic variable VV Puppis, obtained with the Far Ultraviolet Spectroscopic Explorer satellite. In addition, we have obtained simultaneous ground-based optical photometric observations of VV Pup during part of the FUV observation. The shapes of the FUV and optical light curves are consistent with each other and with those of past observations at optical, extreme-ultraviolet, and X-ray wavelengths. Time-resolved FUV spectra during the portion of VV Pup's orbit when the accreting magnetic pole of the white dwarf can be seen show an increasing continuum level as the accretion spot becomes more directly visible. The most prominent features in the spectrum are the O VI λλ1031.9, 1037.6 emission lines. We interpret the shape and velocity shift of these lines in the context of an origin in the accretion funnel near the white dwarf surface. A blackbody function with Tbb>~90,000 K provides an adequate fit to the FUV spectral energy distribution of VV Pup. Based on observations with the NASA-CNES-CSA Far Ultraviolet Spectroscopic Explorer. FUSE is operated for NASA by Johns Hopkins University under NASA contract NAS 5-32985.

A Mixed Methods Sampling Methodology for a Multisite Case Study

ERIC Educational Resources Information Center

Sharp, Julia L.; Mobley, Catherine; Hammond, Cathy; Withington, Cairen; Drew, Sam; Stringfield, Sam; Stipanovic, Natalie

2012-01-01

The flexibility of mixed methods research strategies makes such approaches especially suitable for multisite case studies. Yet the utilization of mixed methods to select sites for these studies is rarely reported. The authors describe their pragmatic mixed methods approach to select a sample for their multisite mixed methods case study of a…

Expansion of the gateway multisite recombination cloning toolkit.

PubMed

Shearin, Harold K; Dvarishkis, Alisa R; Kozeluh, Craig D; Stowers, R Steven

2013-01-01

Precise manipulation of transgene expression in genetic model organisms has led to advances in understanding fundamental mechanisms of development, physiology, and genetic disease. Transgene construction is, however, a precondition of transgene expression, and often limits the rate of experimental progress. Here we report an expansion of the modular Gateway MultiSite recombination-cloning platform for high efficiency transgene assembly. The expansion includes two additional destination vectors and entry clones for the LexA binary transcription system, among others. These new tools enhance the expression levels possible with Gateway MultiSite generated transgenes and make possible the generation of LexA drivers and reporters with Gateway MultiSite cloning. In vivo data from transgenic Drosophila functionally validating each novel component are presented and include neuronal LexA drivers, LexAop2 red and green fluorescent synaptic vesicle reporters, TDC2 and TRH LexA, GAL4, and QF drivers, and LexAop2, UAS, and QUAS channelrhodopsin2 T159C reporters.

Conducting a Multisite Education Research Project: Strategies to Overcome the Barriers to Achieve the Benefits.

PubMed

Beischel, Kelly P; Hart, Julie; Turkelson, Sandra L

2016-01-01

Multisite education research projects have many benefits as well as perceived barriers. In this article, we share our experiences with a multisite education research project and the barriers we overcame to reap the benefits. The outcome of our research resulted in increased rigor, role-modeling professional collaboration, and promotion of future multisite education studies. The strategies presented in this article will help alleviate perceived barriers and ameliorate the process of conducting multisite education research studies.

Voxel-based morphometric multisite collaborative study on schizophrenia.

PubMed

Segall, Judith M; Turner, Jessica A; van Erp, Theo G M; White, Tonya; Bockholt, H Jeremy; Gollub, Randy L; Ho, Beng C; Magnotta, Vince; Jung, Rex E; McCarley, Robert W; Schulz, S Charles; Lauriello, John; Clark, Vince P; Voyvodic, James T; Diaz, Michele T; Calhoun, Vince D

2009-01-01

Regional gray matter (GM) abnormalities are well known to exist in patients with chronic schizophrenia. Voxel-based morphometry (VBM) has been previously used on structural magnetic resonance images (MRI) data to characterize these abnormalities. Two multisite schizophrenia studies, the Functional Biomedical Informatics Research Network and the Mind Clinical Imaging Consortium, which include 9 data collection sites, are evaluating the efficacy of pooling structural imaging data across imaging centers. Such a pooling of data could yield the increased statistical power needed to elucidate effects that may not be seen with smaller samples. VBM analyses were performed to evaluate the consistency of patient versus control gray matter concentration (GMC) differences across the study sites, as well as the effects of combining multisite data. Integration of data from both studies yielded a large sample of 503 subjects, including 266 controls and 237 patients diagnosed with schizophrenia, schizoaffective or schizophreniform disorder. The data were analyzed using the combined sample, as well as analyzing each of the 2 multisite studies separately. A consistent pattern of reduced relative GMC in schizophrenia patients compared with controls was found across all study sites. Imaging center-specific effects were evaluated using a region of interest analysis. Overall, the findings support the use of VBM in combined multisite studies. This analysis of schizophrenics and controls from around the United States provides continued supporting evidence for GM deficits in the temporal lobes, anterior cingulate, and frontal regions in patients with schizophrenia spectrum disorders.

The spectroscopic observation of the CH radical in its a4Sigma(-) state

NASA Technical Reports Server (NTRS)

Nelis, Thomas; Brown, John M.; Evenson, Kenneth M.

1988-01-01

The first spectroscopic observation of CH in the a 4Sigma(0-) state are reported. The molecule was generated in a discharge-flow system in the reaction betweeen fluorine atoms and methane or between oxygen atoms and acetylene at a total pressure of about 1 Torr. Several resonances associated with the N = 1 - 0 transitions of 4Sigma(-) CH were observed at three separate laser wavelengths, while those for the N = 2 - 1 transition were observed at two wavelengths. Each observed Zeeman component consists of a well-split doublet arising from proton hyperfine structure. The reasons for assigning the observations to CH in its a 4Sigma(-) state are discussed.

Reduced-complexity multi-site rainfall generation: one million years over night using the model TripleM

NASA Astrophysics Data System (ADS)

Breinl, Korbinian; Di Baldassarre, Giuliano; Girons Lopez, Marc

2017-04-01

We assess uncertainties of multi-site rainfall generation across spatial scales and different climatic conditions. Many research subjects in earth sciences such as floods, droughts or water balance simulations require the generation of long rainfall time series. In large study areas the simulation at multiple sites becomes indispensable to account for the spatial rainfall variability, but becomes more complex compared to a single site due to the intermittent nature of rainfall. Weather generators can be used for extrapolating rainfall time series, and various models have been presented in the literature. Even though the large majority of multi-site rainfall generators is based on similar methods, such as resampling techniques or Markovian processes, they often become too complex. We think that this complexity has been a limit for the application of such tools. Furthermore, the majority of multi-site rainfall generators found in the literature are either not publicly available or intended for being applied at small geographical scales, often only in temperate climates. Here we present a revised, and now publicly available, version of a multi-site rainfall generation code first applied in 2014 in Austria and France, which we call TripleM (Multisite Markov Model). We test this fast and robust code with daily rainfall observations from the United States, in a subtropical, tropical and temperate climate, using rain gauge networks with a maximum site distance above 1,000km, thereby generating one million years of synthetic time series. The modelling of these one million years takes one night on a recent desktop computer. In this research, we first start the simulations with a small station network of three sites and progressively increase the number of sites and the spatial extent, and analyze the changing uncertainties for multiple statistical metrics such as dry and wet spells, rainfall autocorrelation, lagged cross correlations and the inter-annual rainfall

Multi-Sited Global Ethnography and Travel: Gendered Journeys in Three Registers

ERIC Educational Resources Information Center

Epstein, Debbie; Fahey, Johannah; Kenway, Jane

2013-01-01

This paper joins a barely begun conversation about multi-sited and global ethnography in educational research; a conversation that is likely to intensify along with growing interest in the links between education, globalisation, internationalisation and transnationalism. Drawing on an ongoing multi-sited global ethnography of elite schools and…

Exploiting Multisite Gateway and pENFRUIT plasmid collection for fruit genetic engineering.

PubMed

Estornell, Leandro H; Granell, Antonio; Orzaez, Diego

2012-01-01

MultiSite Gateway cloning techniques based on homologous recombination facilitate the combinatorial assembly of basic genetic pieces (i.e., promoters, CDS, and terminators) into gene expression or gene silencing cassettes. pENFRUIT is a collection of MultiSite Triple Gateway Entry vectors dedicated to genetic engineering in fruits. It comprises a number of fruit-operating promoters as well as C-terminal tags adapted to the Gateway standard. In this way, flanking regulatory/labeling sequences can be easily Gateway-assembled with a given gene of interest for its ectopic expression or silencing in fruits. The resulting gene constructs can be analyzed in stable transgenic plants or in transient expression assays, the latter allowing fast testing of the increasing number of combinations arising from MultiSite methodology. A detailed description of the use of MultiSite cloning methodology for the assembly of pENFRUIT elements is presented.

SHRINE: Enabling Nationally Scalable Multi-Site Disease Studies

PubMed Central

McMurry, Andrew J.; Murphy, Shawn N.; MacFadden, Douglas; Weber, Griffin; Simons, William W.; Orechia, John; Bickel, Jonathan; Wattanasin, Nich; Gilbert, Clint; Trevvett, Philip; Churchill, Susanne; Kohane, Isaac S.

2013-01-01

Results of medical research studies are often contradictory or cannot be reproduced. One reason is that there may not be enough patient subjects available for observation for a long enough time period. Another reason is that patient populations may vary considerably with respect to geographic and demographic boundaries thus limiting how broadly the results apply. Even when similar patient populations are pooled together from multiple locations, differences in medical treatment and record systems can limit which outcome measures can be commonly analyzed. In total, these differences in medical research settings can lead to differing conclusions or can even prevent some studies from starting. We thus sought to create a patient research system that could aggregate as many patient observations as possible from a large number of hospitals in a uniform way. We call this system the ‘Shared Health Research Information Network’, with the following properties: (1) reuse electronic health data from everyday clinical care for research purposes, (2) respect patient privacy and hospital autonomy, (3) aggregate patient populations across many hospitals to achieve statistically significant sample sizes that can be validated independently of a single research setting, (4) harmonize the observation facts recorded at each institution such that queries can be made across many hospitals in parallel, (5) scale to regional and national collaborations. The purpose of this report is to provide open source software for multi-site clinical studies and to report on early uses of this application. At this time SHRINE implementations have been used for multi-site studies of autism co-morbidity, juvenile idiopathic arthritis, peripartum cardiomyopathy, colorectal cancer, diabetes, and others. The wide range of study objectives and growing adoption suggest that SHRINE may be applicable beyond the research uses and participating hospitals named in this report. PMID:23533569

Expansion of the Gateway MultiSite Recombination Cloning Toolkit

PubMed Central

Shearin, Harold K.; Dvarishkis, Alisa R.; Kozeluh, Craig D.; Stowers, R. Steven

2013-01-01

Precise manipulation of transgene expression in genetic model organisms has led to advances in understanding fundamental mechanisms of development, physiology, and genetic disease. Transgene construction is, however, a precondition of transgene expression, and often limits the rate of experimental progress. Here we report an expansion of the modular Gateway MultiSite recombination-cloning platform for high efficiency transgene assembly. The expansion includes two additional destination vectors and entry clones for the LexA binary transcription system, among others. These new tools enhance the expression levels possible with Gateway MultiSite generated transgenes and make possible the generation of LexA drivers and reporters with Gateway MultiSite cloning. In vivo data from transgenic Drosophila functionally validating each novel component are presented and include neuronal LexA drivers, LexAop2 red and green fluorescent synaptic vesicle reporters, TDC2 and TRH LexA, GAL4, and QF drivers, and LexAop2, UAS, and QUAS channelrhodopsin2 T159C reporters. PMID:24204935

A comparison of single- and multi-site calibration and validation: a case study of SWAT in the Miyun Reservoir watershed, China

NASA Astrophysics Data System (ADS)

Bai, Jianwen; Shen, Zhenyao; Yan, Tiezhu

2017-09-01

An essential task in evaluating global water resource and pollution problems is to obtain the optimum set of parameters in hydrological models through calibration and validation. For a large-scale watershed, single-site calibration and validation may ignore spatial heterogeneity and may not meet the needs of the entire watershed. The goal of this study is to apply a multi-site calibration and validation of the Soil andWater Assessment Tool (SWAT), using the observed flow data at three monitoring sites within the Baihe watershed of the Miyun Reservoir watershed, China. Our results indicate that the multi-site calibration parameter values are more reasonable than those obtained from single-site calibrations. These results are mainly due to significant differences in the topographic factors over the large-scale area, human activities and climate variability. The multi-site method involves the division of the large watershed into smaller watersheds, and applying the calibrated parameters of the multi-site calibration to the entire watershed. It was anticipated that this case study could provide experience of multi-site calibration in a large-scale basin, and provide a good foundation for the simulation of other pollutants in followup work in the Miyun Reservoir watershed and other similar large areas.

Bias and Bias Correction in Multisite Instrumental Variables Analysis of Heterogeneous Mediator Effects

ERIC Educational Resources Information Center

Reardon, Sean F.; Unlu, Fatih; Zhu, Pei; Bloom, Howard S.

2014-01-01

We explore the use of instrumental variables (IV) analysis with a multisite randomized trial to estimate the effect of a mediating variable on an outcome in cases where it can be assumed that the observed mediator is the only mechanism linking treatment assignment to outcomes, an assumption known in the IV literature as the exclusion restriction.…

Comparing Simulated and Observed Spectroscopic Signatures of Mix in Omega Capsules

NASA Astrophysics Data System (ADS)

Tregillis, I. L.; Shah, R. C.; Hakel, P.; Cobble, J. A.; Murphy, T. J.; Krasheninnikova, N. S.; Hsu, S. C.; Bradley, P. A.; Schmitt, M. J.; Batha, S. H.; Mancini, R. C.

2012-10-01

The Defect-Induced Mix Experiment (DIME) campaign at Los Alamos National Laboratory uses multi-monochromatic X-ray imaging (MMI)footnotetextT. Nagayama, R.C. Mancini, R. Florido, et al, J. App. Phys. 109, 093303 (2011) to detect the migration of high-Z spectroscopic dopants into the hot core of an imploded capsule. We have developed an MMI post-processing tool for producing synthetic datasets from two- and three-dimensional Lagrangian numerical simulations of Omega and NIF shots. These synthetic datasets are of sufficient quality, and contain sufficient physics, that they can be analyzed in the same manner as actual MMI data. We have carried out an extensive comparison between simulated and observed MMI data for a series of polar direct-drive shots carried out at the Omega laser facility in January, 2011. The capsule diameter was 870 microns; the 15 micron CH ablators contained a 2 micron Ti-doped layer along the inner edge. All capsules were driven with 17 kJ; some capsules were manufactured with an equatorial ``trench'' defect. This talk will focus on the construction of spectroscopic-quality synthetic MMI datasets from numerical simulations, and their correlation with MMI measurements.

Development of a continuous multisite accelerometry system for studying movements during sleep.

PubMed

Terrill, Philip I; Mason, David G; Wilson, Stephen J

2010-01-01

Actigraphy has proven to be a useful tool in the assessment of circadian rhythms, and more recently in the automatic staging of sleep and wake states. Whilst accuracy of commercial systems appears good over 24 hour periods, the sensitivity of detecting wake during time in bed is poor. One possible explanation for these poor results is the technical limitations of currently available commercial actigraphs. In particular, raw data is generally not available to the user. Instead, activity counts for each epoch (typically between 10-60 secs) are calculated using various algorithms, from which sleep state is identified. Consequently morphologically different movements observed during sleep and wake states may not be detected as such. In this paper, the development of a continuous multisite, accelerometry system (CMAS) is described. Initial results, comparing data collected using a commercial actigraph (Actiwatch- Mini Motionlogger), and the continuous multisite accelerometry system are presented. The CMAS is able to differentiate brief movement "twitches" from postural changes.

Culture and Influence in Multisite Evaluation

ERIC Educational Resources Information Center

Kirkhart, Karen E.

2011-01-01

Understanding the influence of multisite evaluation requires careful consideration of cultural context. The author illustrates dimensions of influence and culture with excerpts from four National Science Foundation evaluation case studies and summarizes what influence teaches everyone about culture and what culture teaches everyone about…

Spectroscopic Observations of Nearby Low Mass Stars

NASA Astrophysics Data System (ADS)

Vican, Laura; Zuckerman, B. M.; Rodriguez, D.

2014-01-01

Young low-mass stars are known to be bright in X-ray and UV due to a high level of magnetic activity. By cross-correlating the GALEX Catalog with the WISE and 2MASS Point Source Catalogs, we have identified more than 2,000 stars whose UV excesses suggest ages in the 10-100 Myr range. We used the Shane 3-m telescope at Lick Observatory on Mount Hamilton, California to observe some of these 2,000 stars spectroscopically. We measured the equivalent width of lithium at 6708 A absorption and H-alpha emission lines. Out of a total of 122 stars observed with the Kast grating spectrometer, we find that roughly 10% have strong lithium absorption features. The high percentage of stars with lithium present is further evidence of the importance of UV emission as a youth indicator for low-mass stars. In addition, we used high-resolution spectra obtained with the Hamilton echelle spectrograph to determine radial velocities for several UV-bright stars. These radial velocities will be useful for the calculation of Galactic UVW space velocities for determination of possible moving group membership. This work is supported by NASA Astrophysics Data Analysis Program award NNX12AH37G to RIT and UCLA and Chilean FONDECYT grant 3130520 to Universidad de Chile. This submission presents work for the GALNYSS project and should be linked to abstracts submitted by David Rodriguez, Laura Vican, and Joel Kastner.

Mixed mechanisms of multi-site phosphorylation

PubMed Central

Suwanmajo, Thapanar; Krishnan, J.

2015-01-01

Multi-site phosphorylation is ubiquitous in cell biology and has been widely studied experimentally and theoretically. The underlying chemical modification mechanisms are typically assumed to be distributive or processive. In this paper, we study the behaviour of mixed mechanisms that can arise either because phosphorylation and dephosphorylation involve different mechanisms or because phosphorylation and/or dephosphorylation can occur through a combination of mechanisms. We examine a hierarchy of models to assess chemical information processing through different mixed mechanisms, using simulations, bifurcation analysis and analytical work. We demonstrate how mixed mechanisms can show important and unintuitive differences from pure distributive and processive mechanisms, in some cases resulting in monostable behaviour with simple dose–response behaviour, while in other cases generating new behaviour-like oscillations. Our results also suggest patterns of information processing that are relevant as the number of modification sites increases. Overall, our work creates a framework to examine information processing arising from complexities of multi-site modification mechanisms and their impact on signal transduction. PMID:25972433

Bias and Bias Correction in Multi-Site Instrumental Variables Analysis of Heterogeneous Mediator Effects

ERIC Educational Resources Information Center

Reardon, Sean F.; Unlu, Faith; Zhu, Pei; Bloom, Howard

2013-01-01

We explore the use of instrumental variables (IV) analysis with a multi-site randomized trial to estimate the effect of a mediating variable on an outcome in cases where it can be assumed that the observed mediator is the only mechanism linking treatment assignment to outcomes, as assumption known in the instrumental variables literature as the…

Frequency and mode identification of γ Doradus from photometric and spectroscopic observations*

NASA Astrophysics Data System (ADS)

Brunsden, E.; Pollard, K. R.; Wright, D. J.; De Cat, P.; Cottrell, P. L.

2018-04-01

The prototype star for the γ Doradus class of pulsating variables was studied employing photometric and spectroscopic observations to determine the frequencies and modes of pulsation. The four frequencies found are self-consistent between the observation types and almost identical to those found in previous studies (1.3641 d-1, 1.8783 d-1, 1.4742 d-1, and 1.3209 d-1). Three of the frequencies are classified as l, m = (1, 1) pulsations and the other is ambiguous between l, m = (2, 0) and (2, -2) modes. Two frequencies are shown to be stable over 20 yr since their first identification. The agreement in ground-based work makes this star an excellent calibrator between high-precision photometry and spectroscopy with the upcoming TESS observations and a potential standard for continued asteroseismic modelling.

Multisite occupation of divalent dopants in barium and strontium titanates

NASA Astrophysics Data System (ADS)

Zulueta, Yohandys A.; Nguyen, Minh Tho

2018-10-01

Based on recent experimental and theoretical proofs of calcium multisite occupation in barium titanate, we investigated a mixed incorporation mechanism for divalent dopants in barium and strontium titanates (BaTiO3 and SrTiO3). Our present theoretical results demonstrated the multisite occupation of divalent dopants in both perovskite structures. We determined the dependences of the solution, binding energies, and final solution energies with respect to the ionic radii of the dopants. Calculated results obtained based on classical simulations showed that the divalent dopants can occupy both A- and Ti- cation sites in ATiO3 perovskite structures. Such a multisite occupation has direct implications for other experimental findings regarding BaTiO3, such as non-stabilization of the tetragonal phase, shifts in the Curie temperature, intensification of the diffuse phase transition, and shifts in the absorption of ultraviolet light to the visible range in photocatalytic applications related to solar cells for producing energy.

High-Resolution Spectroscopic Database for the NASA Earth Observing System Program

NASA Technical Reports Server (NTRS)

Rothman, Laurence

2003-01-01

The purpose of this project is to develop and enhance the HITRAN molecular spectroscopic database and associated software to support the observational programs of the Earth Observing System (EOS). In particular, the focus is on the EOS projects: the Atmospheric Infrared Sounder (AIRS), the High-Resolution Dynamics Limb Sounder (HIRDLS), Measurements of Pollution in the Troposphere (MOPITT), the Tropospheric Emission Spectrometer (TES), and the Stratospheric Aerosol and Gas Experiment (SAGE III). The HITRAN program is also involved in the Ozone Monitoring Experiment (OMI). The data requirements of these programs in terms of spectroscopy are varied with respect to constituents being observed, required remote-sensing parameters, and spectral coverage. A general requisite is for additional spectral parameters and improvements to existing molecular bands sufficient for the simulation of the observations leading to retrieval of the atmospheric state. In addition, cross-section data for heavier molecular species must be expanded and made amenable to modeling in remote sensing. The effort in the project also includes developing software and distribution to make access, manipulation, and use of HITRAN functional to the EOS program.

High Resolution Spectroscopic Database for the NASA Earth Observing System Program

NASA Technical Reports Server (NTRS)

Rothman, Laurence

2004-01-01

The purpose of this project has been to develop and enhance the HITRAN molecular spectroscopic database and associated software to support the observational programs of the Earth Observing System (EOS). Emphasis has been on the EOS projects: the Atmospheric Infrared Sounder (AIRS), the High-Resolution Dynamics Limb Sounder (HIRDLS), Measurements of Pollution in the Troposphere (MOPITT), the Tropospheric Emission Spectrometer (TES), and the Stratospheric Aerosol and Gas Experiment (SAGE III). The HITRAN program is also involved in the Ozone Monitoring Experiment (OMI). The data requirements of these programs in terms of spectroscopy are varied with respect to constituents being observed, required remote-sensing parameters, and spectral coverage. A general requisite is for additional spectral parameters and improvements to existing molecular bands sufficient for the simulation of the observations leading to retrieval of the atmospheric state. In addition, cross-section data for heavier molecular species must be expanded and made amenable to modeling in remote sensing. The effort in the project also includes developing software and distribution to make access, manipulation, and use of HITRAN functional to the EOS program.

High-Resolution Spectroscopic Database for the NASA Earth Observing System Program

NASA Technical Reports Server (NTRS)

Rothman, Laurence S.

2004-01-01

The purpose of this project is to develop and enhance the HITRAN molecular spectroscopic database and associated - software to support the observational programs of the Earth observing System (EOS). In particular, the focus is on the EOS projects: the Atmospheric Infrared Sounder (AIRS), the High-Resolution Dynamics Limb Sounder (HIRDLS), Measurements of Pollution in the Troposphere (MOPITT), the Tropospheric Emission Spectrometer (TES), and the Stratospheric Aerosol and Gas Experiment (SAGE III). The HITRAN program is also involved in the Ozone Monitoring Experiment (OMI). The data requirements of these programs in terms of spectroscopy are varied with respect to constituents being observed, required remote-sensing parameters, and spectral coverage. A general requisite is for additional spectral parameters and improvements to existing molecular bands sufficient for the simulation of the observations leading to retrieval of the atmospheric state. In addition cross-section data for heavier molecular species must be expanded and made amenable to modeling in remote sensing. The effort in the project also includes developing software and distribution to make access, manipulation, and use HITRAN functional to the EOS program.

High-Resolution Spectroscopic Database for the NASA Earth Observing System Program

NASA Technical Reports Server (NTRS)

Rothman, Laurence S.; Starr, David (Technical Monitor)

2002-01-01

The purpose of this project is to develop and enhance the HITRAN molecular spectroscopic database and associated software to support the observational programs of the Earth Observing System (EOS). In particular, the focus is on the EOS projects: the Atmospheric Infrared Sounder (AIRS), the High-Resolution Dynamics Limb Sounder (HIRDLS), Measurements of Pollution in the Troposphere (MOPITT), the Tropospheric Emission Spectrometer (TES), and the Stratospheric Aerosol and Gas Experiment (SAGE III). The data requirements of these programs in terms of spectroscopy are varied, but usually call for additional spectral parameters or improvements to existing molecular bands. In addition, cross-section data for heavier molecular species must be expanded and made amenable to modeling in remote sensing. The effort in the project also includes developing software and distribution to make access, manipulation, and use of HITRAN functional to the EOS program.

Multisite accelerometry for sleep and wake classification in children.

PubMed

Lamprecht, Marnie L; Bradley, Andrew P; Tran, Tommy; Boynton, Alison; Terrill, Philip I

2015-01-01

Actigraphy is a useful alternative to the gold standard polysomnogram for non-invasively measuring sleep and wakefulness. However, it is unable to accurately assess sleep fragmentation due to its inability to differentiate restless sleep from wakefulness and quiet wake from sleep. This presents significant limitations in the assessment of sleep-related breathing disorders where sleep fragmentation is a common symptom. We propose that this limitation may be caused by hardware constraints and movement representation techniques. Our objective was to determine if multisite tri-axial accelerometry improves sleep and wake classification. Twenty-four patients aged 6-15 years (median: 8 years, 16 male) underwent a diagnostic polysomnogram while simultaneously recording motion from the left wrist and index fingertip, upper thorax and left ankle and great toe using a custom accelerometry system. Movement was quantified using several features and two feature selection techniques were employed to select optimal features for restricted feature set sizes. A heuristic was also applied to identify movements during restless sleep. The sleep and wake classification performance was then assessed and validated against the manually scored polysomnogram using discriminant analysis. Tri-axial accelerometry measured at the wrist significantly improved the wake detection when compared to uni-axial accelerometry (specificity at 85% sensitivity: 71.3(14.2)% versus 55.2(24.7)%, p < 0.01). Multisite accelerometry significantly improved the performance when compared to the single wrist placement (specificity at 85% sensitivity: 82.1(12.5)% versus 71.3(14.2)%, p < 0.05). Our results indicate that multisite accelerometry offers a significant performance benefit which could be further improved by analysing movement in raw multisite accelerometry data.

User acceptance of observation and response charts with a track and trigger system: a multisite staff survey.

PubMed

Elliott, Doug; Allen, Emily; McKinley, Sharon; Perry, Lin; Duffield, Christine; Fry, Margaret; Gallagher, Robyn; Iedema, Rick; Roche, Michael

2016-08-01

To examine user acceptance with a new format of charts for recording observations and as a prompt for responding to episodes of clinical deterioration in adult medical-surgical patients. Improving recognition and response to clinical deterioration remains a challenge for acute healthcare institutions globally. Five chart templates were developed in Australia, combining human factors design principles with a track and trigger system for escalation of care. Two chart templates were previously tested in simulations, but none had been evaluated in clinical practice. Prospective multisite survey of user acceptance of the charts in practice. New observation and response charts were trialled in parallel with existing charts for 24 hours across 36 adult acute medical-surgical wards, covering 108 shifts, in five Australian states. Surveys were completed by 477 staff respondents, with open-ended comments and narrative from short informal feedback groups providing elaboration and context of user experiences. Respondents were broadly supportive of the chart format and content for monitoring patients, and as a prompt for escalating care. Some concerns were noted for chart size and style, use of ranges to graph vital signs and with specific human factors design features. Information and training issues were identified to improve usability and adherence to chart guidelines and to support improved detection and response for patients with clinical deterioration. This initial evaluation demonstrated that the charts were perceived as appropriate for documenting observations and as a prompt to detect clinical deterioration. Further evaluation after some minor modifications to the chart is recommended. Explicit training on the principles and rationale of human factors chart design, use of embedded change management strategies and addressing practical issues will improve authentic engagement, staff acceptance and adoption by all clinical users when implementing a similar observation

Latent Variable Regression 4-Level Hierarchical Model Using Multisite Multiple-Cohorts Longitudinal Data. CRESST Report 801

ERIC Educational Resources Information Center

Choi, Kilchan

2011-01-01

This report explores a new latent variable regression 4-level hierarchical model for monitoring school performance over time using multisite multiple-cohorts longitudinal data. This kind of data set has a 4-level hierarchical structure: time-series observation nested within students who are nested within different cohorts of students. These…

Multiperiod planning tool for multisite pig production systems.

PubMed

Nadal-Roig, E; Plà, L M

2014-09-01

This paper presents a multiperiod planning tool for multisite pig production systems based on Linear Programming (LP). The aim of the model is to help pig managers of multisite systems in making short-term decisions (mainly related to pig transfers between farms and batch management in fattening units) and mid-term or long-term decisions (according to company targets and expansion strategy). The model skeleton follows the structure of a three-site system that can be adapted to any multisite system present in the modern pig industry. There are three basic phases, namely, piglet production, rearing pigs, and fattening. Each phase involves a different set of farms; therefore, transportation between farms and delivering of pigs to the abattoir are under consideration. The model maximizes the total gross margin calculated from the income of sales to the abattoir and the production costs over the time horizon considered. Production cost depends on each type of farm involved in the process. Parameters like number of farms per phase and distance, farm capacity, reproduction management policies, feeding and veterinary expenses, and transportation costs are taken into account. The model also provides a schedule of transfers between farms in terms of animals to be transported and number of trucks involved. The use of the model is illustrated with a case study based on a real instance of a company located in Catalonia (Spain).

Non-Gaussian spatiotemporal simulation of multisite daily precipitation: downscaling framework

NASA Astrophysics Data System (ADS)

Ben Alaya, M. A.; Ouarda, T. B. M. J.; Chebana, F.

2018-01-01

Probabilistic regression approaches for downscaling daily precipitation are very useful. They provide the whole conditional distribution at each forecast step to better represent the temporal variability. The question addressed in this paper is: how to simulate spatiotemporal characteristics of multisite daily precipitation from probabilistic regression models? Recent publications point out the complexity of multisite properties of daily precipitation and highlight the need for using a non-Gaussian flexible tool. This work proposes a reasonable compromise between simplicity and flexibility avoiding model misspecification. A suitable nonparametric bootstrapping (NB) technique is adopted. A downscaling model which merges a vector generalized linear model (VGLM as a probabilistic regression tool) and the proposed bootstrapping technique is introduced to simulate realistic multisite precipitation series. The model is applied to data sets from the southern part of the province of Quebec, Canada. It is shown that the model is capable of reproducing both at-site properties and the spatial structure of daily precipitations. Results indicate the superiority of the proposed NB technique, over a multivariate autoregressive Gaussian framework (i.e. Gaussian copula).

Work-related determinants of multi-site musculoskeletal pain among employees in the health care sector.

PubMed

Neupane, Subas; Nygård, Clas-Håkan; Oakman, Jodi

2016-06-16

Work-related musculoskeletal pain is a major occupational problem. Those with pain in multiple sites usually report worse health outcomes than those with pain in one site. This study explored prevalence and associated predictors of multi-site pain in health care sector employees. Survey responses from 1348 health care sector employees across three organisations (37% response rate) collected data on job satisfaction, work life balance, psychosocial and physical hazards, general health and work ability. Musculoskeletal discomfort was measured across 5 body regions with pain in ≥ 2 sites defined as multi-site pain. Generalized linear models were used to identify relationships between work-related factors and multi-site pain. Over 52% of the employees reported pain in multiple body sites and 19% reported pain in one site. Poor work life balance (PRR = 2.33, 95% CI = 1.06-5.14). physical (PRR = 7.58, 95% CI = 4.89-11.77) and psychosocial (PRR = 1.59, 95% CI = 1.00-2.57) hazard variables were related to multi-site pain (after controlling for age, gender, health and work ability. Older employees and females were more likely to report multi-site pain. Effective risk management of work related multi-site pain must include identification and control of psychosocial and physical hazards.

Multisite Phosphorylation Modulates the T Cell Receptor ζ-Chain Potency but not the Switchlike Response.

PubMed

Mukhopadhyay, Himadri; de Wet, Ben; Clemens, Lara; Maini, Philip K; Allard, Jun; van der Merwe, P Anton; Dushek, Omer

2016-04-26

Multisite phosphorylation is ubiquitous in cellular signaling and is thought to provide signaling proteins with additional regulatory mechanisms. Indeed, mathematical models have revealed a large number of mechanisms by which multisite phosphorylation can produce switchlike responses. The T cell antigen receptor (TCR) is a multisubunit receptor on the surface of T cells that is a prototypical multisite substrate as it contains 20 sites that are distributed on 10 conserved immunoreceptor tyrosine-based activation motifs (ITAMs). The TCR ζ-chain is a homodimer subunit that contains six ITAMs (12 sites) and exhibits a number of properties that are predicted to be sufficient for a switchlike response. We have used cellular reconstitution to systematically study multisite phosphorylation of the TCR ζ-chain. We find that multisite phosphorylation proceeds by a nonsequential random mechanism, and find no evidence that multiple ITAMs modulate a switchlike response but do find that they alter receptor potency and maximum phosphorylation. Modulation of receptor potency can be explained by a reduction in molecular entropy of the disordered ζ-chain upon phosphorylation. We further find that the tyrosine kinase ZAP-70 increases receptor potency but does not modulate the switchlike response. In contrast to other multisite proteins, where phosphorylations act in strong concert to modulate protein function, we suggest that the multiple ITAMs on the TCR function mainly to amplify subsequent signaling. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

SPECTROSCOPIC OBSERVATIONS OF AN EVOLVING FLARE RIBBON SUBSTRUCTURE SUGGESTING ORIGIN IN CURRENT SHEET WAVES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Brannon, S. R.; Longcope, D. W.; Qiu, J.

2015-09-01

We present imaging and spectroscopic observations from the Interface Region Imaging Spectrograph of the evolution of the flare ribbon in the SOL2014-04-18T13:03 M-class flare event, at high spatial resolution and time cadence. These observations reveal small-scale substructure within the ribbon, which manifests as coherent quasi-periodic oscillations in both position and Doppler velocities. We consider various alternative explanations for these oscillations, including modulation of chromospheric evaporation flows. Among these, we find the best support for some form of wave localized to the coronal current sheet, such as a tearing mode or Kelvin–Helmholtz instability.

Spectroscopic Observations of the Mass Donor Star in SS 433

NASA Astrophysics Data System (ADS)

Hillwig, T. C.; Gies, D. R.

2008-03-01

The microquasar SS 433 is an interacting massive binary consisting of an evolved mass donor and a compact companion that ejects relativistic jets. The mass donor was previously identified through spectroscopic observations of absorption lines in the blue part of the spectrum that showed Doppler shifts associated with orbital motion and strength variations related to the orbital modulation of the star-to-disk flux ratio and to disk obscuration. However, subsequent observations revealed other absorption features that lacked these properties and that were probably formed in the disk gas outflow. We present follow-up observations of SS 433 at orbital and precession phases identical to those from several previous studies, with the goals of confirming the detection of the mass donor spectrum and providing more reliable masses for the two system components. We show that the absorption features present as well as those previously observed almost certainly belong to the mass donor star, and find revised masses of 12.3 ± 3.3 and 4.3 ± 0.8 M⊙ for the mass donor and compact object, respectively. Based on observations obtained at the Gemini Observatory, which is operated by the Association of Universities for Research in Astronomy, Inc., under a cooperative agreement with the NSF on behalf of the Gemini partnership: the National Science Foundation (US), the Science and Technology Facilities Council (UK), the National Research Council (Canada), CONICYT (Chile), the Australian Research Council (Australia), CNPq (Brazil), and SECYT (Argentina).

Multisite stochastic simulation of daily precipitation from copula modeling with a gamma marginal distribution

NASA Astrophysics Data System (ADS)

Lee, Taesam

2018-05-01

Multisite stochastic simulations of daily precipitation have been widely employed in hydrologic analyses for climate change assessment and agricultural model inputs. Recently, a copula model with a gamma marginal distribution has become one of the common approaches for simulating precipitation at multiple sites. Here, we tested the correlation structure of the copula modeling. The results indicate that there is a significant underestimation of the correlation in the simulated data compared to the observed data. Therefore, we proposed an indirect method for estimating the cross-correlations when simulating precipitation at multiple stations. We used the full relationship between the correlation of the observed data and the normally transformed data. Although this indirect method offers certain improvements in preserving the cross-correlations between sites in the original domain, the method was not reliable in application. Therefore, we further improved a simulation-based method (SBM) that was developed to model the multisite precipitation occurrence. The SBM preserved well the cross-correlations of the original domain. The SBM method provides around 0.2 better cross-correlation than the direct method and around 0.1 degree better than the indirect method. The three models were applied to the stations in the Nakdong River basin, and the SBM was the best alternative for reproducing the historical cross-correlation. The direct method significantly underestimates the correlations among the observed data, and the indirect method appeared to be unreliable.

Spectroscopic survey of southern hemisphere white dwarfs. II. Spectroscopic data for forty-one southern white dwarfs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wegner, G.

New spectroscopic data on 41 southern white dwarfs are presented. Most of these stars have not teen previously observed spectroscopically. Spectral types, as well as equivalent widths and line profiles for a few selected lines, are given. (auth)

Tools and Methods for Risk Management in Multi-Site Engineering Projects

NASA Astrophysics Data System (ADS)

Zhou, Mingwei; Nemes, Laszlo; Reidsema, Carl; Ahmed, Ammar; Kayis, Berman

In today's highly global business environment, engineering and manufacturing projects often involve two or more geographically dispersed units or departments, research centers or companies. This paper attempts to identify the requirements for risk management in a multi-site engineering project environment, and presents a review of the state-of-the-art tools and methods that can be used to manage risks in multi-site engineering projects. This leads to the development of a risk management roadmap, which will underpin the design and implementation of an intelligent risk mapping system.

Multisite Ion Model in Concentrated Solutions of Divalent Cations (MgCl2 and CaCl2): Osmotic Pressure Calculations

PubMed Central

2015-01-01

Accurate force field parameters for ions are essential for meaningful simulation studies of proteins and nucleic acids. Currently accepted models of ions, especially for divalent ions, do not necessarily reproduce the right physiological behavior of Ca2+ and Mg2+ ions. Saxena and Sept (J. Chem. Theor. Comput.2013, 9, 3538–3542) described a model, called the multisite-ion model, where instead of treating the ions as an isolated sphere, the charge was split into multiple sites with partial charge. This model provided accurate inner shell coordination of the ion with biomolecules and predicted better free energies for proteins and nucleic acids. Here, we expand and refine the multisite model to describe the behavior of divalent ions in concentrated MgCl2 and CaCl2 electrolyte solutions, eliminating the unusual ion–ion pairing and clustering of ions which occurred in the original model. We calibrate and improve the parameters of the multisite model by matching the osmotic pressure of concentrated solutions of MgCl2 to the experimental values and then use these parameters to test the behavior of CaCl2 solutions. We find that the concentrated solutions of both divalent ions exhibit the experimentally observed behavior with correct osmotic pressure, the presence of solvent separated ion pairs instead of direct ion pairs, and no aggregation of ions. The improved multisite model for (Mg2+ and Ca2+) can be used in classical simulations of biomolecules at physiologically relevant salt concentrations. PMID:25482831

Ethics Review for a Multi-Site Project Involving Tribal Nations in the Northern Plains.

PubMed

Angal, Jyoti; Petersen, Julie M; Tobacco, Deborah; Elliott, Amy J

2016-04-01

Increasingly, Tribal Nations are forming ethics review panels, which function separately from institutional review boards (IRBs). The emergence of strong community representation coincides with a widespread effort supported by the U.S. Department of Health & Human Services and other federal agencies to establish a single IRB for all multi-site research. This article underscores the value of a tribal ethics review board and describes the tribal oversight for the Safe Passage Study-a multi-site, community-based project in the Northern Plains. Our experience demonstrates the benefits of tribal ethics review and makes a strong argument for including tribal oversight in future regulatory guidance for multi-site, community-based research. © The Author(s) 2016.

Multiyear and multisite photometric campaigns on the bright high-amplitude pulsating subdwarf B star EC 01541-1409

NASA Astrophysics Data System (ADS)

Reed, M. D.; Kilkenny, D.; O'Toole, S.; Østensen, R. H.; Honer, C.; Gilker, J. T.; Quint, A. C.; Doennig, A. M.; Hicks, L. H.; Thompson, M. A.; McCart, P. A.; Zietsman, E.; Chen, W.-P.; Chen, C.-W.; Lin, C.-C.; Beck, P.; Degroote, P.; Barlow, B. N.; Reichart, D. E.; Nysewander, M. C.; Lacluyze, A. P.; Ivarsen, K. M.; Haislip, J. B.; Baran, A.; Winiarski, M.; Drozdz, M.

2012-03-01

We present follow-up observations of the pulsating subdwarf B (sdB) star EC 01541-1409 as part of our efforts to resolve pulsation spectra for use in asteroseismological analyses. This paper reports on data obtained from a single-site campaign, during 2008, and a multisite campaign, during 2009. From limited 2008 data, we were able to clearly resolve and pre-whiten 24 periods. A subsequent multisite campaign spanning nearly 2 months found over 30 individual periodicities most of which were unstable in amplitude and/or phase. Pulsation amplitudes were found to the detection limit, meaning that further observations would likely reveal more periodicities. EC 01541-1409 reveals itself to be one of two sdB pulsators with many pulsation frequencies covering a large frequency range. Unlike the other star of this type (PG 0048+091), it has one high-amplitude periodicity which appears phase stable, making EC 01541-1409 an excellent candidate for exoplanet studies via pulsation phases. No multiplets were detected leaving EC 01541-1409 as yet another rich p-mode sdB pulsator without these features, limiting observational constraints on pulsation modes.

Psychosocial stress and multi-site musculoskeletal pain: a cross-sectional survey of patient care workers.

PubMed

Sembajwe, Grace; Tveito, Torill Helene; Hopcia, Karen; Kenwood, Christopher; O'Day, Elizabeth Tucker; Stoddard, Anne M; Dennerlein, Jack T; Hashimoto, Dean; Sorensen, Glorian

2013-03-01

The aim of this study was to assess the relationship between psychosocial factors at work and multi-site musculoskeletal pain among patient care workers. In a survey of 1,572 workers from two hospitals, occupational psychosocial factors and health outcomes of workers with single and multi-site pain were evaluated using items from the Job Content Questionnaire that was designed to measure psychological demands, decision latitude, and social support. An adapted Nordic Questionnaire provided data on the musculoskeletal pain outcome. Covariates included body mass index, age, gender, and occupation. The analyses revealed statistically significant associations between psychosocial demands and multi-site musculoskeletal pain among patient care associates, nurses, and administrative personnel, both men and women. Supervisor support played a significant role for nurses and women. These results remained statistically significant after adjusting for covariates. These results highlight the associations between workplace psychosocial strain and multi-site musculoskeletal pain, setting the stage for future longitudinal explorations. Copyright 2013, SLACK Incorporated.

Multi-level assessment protocol (MAP) for adoption in multi-site clinical trials

PubMed Central

Guydish, J.; Manser, S.T.; Jessup, M.; Tajima, B.; Sears, C.; Montini, T.

2010-01-01

The National Institute on Drug Abuse (NIDA) Clinical Trials Network (CTN) is intended to test promising drug abuse treatment models in multi-site clinical trials, and to support adoption of new interventions into clinical practice. Using qualitative research methods we asked: How might the technology of multi-site clinical trials be modified to better support adoption of tested interventions? A total of 42 participants, representing 8 organizational levels ranging from clinic staff to clinical trial leaders, were interviewed about their role in the clinical trial, its interactions with clinics, and intervention adoption. Among eight clinics participating in the clinical trial, we found adoption of the tested intervention in one clinic only. In analysis of interview data we identified four conceptual themes which are likely to affect adoption and may be informative in future multi-site clinical trials. We offer the conclusion that planning for adoption in the early stages of protocol development will better serve the aim of integrating new interventions into practice. PMID:20890376

A Hierarchical Modeling Approach to Data Analysis and Study Design in a Multi-Site Experimental fMRI Study

ERIC Educational Resources Information Center

Zhou, Bo; Konstorum, Anna; Duong, Thao; Tieu, Kinh H.; Wells, William M.; Brown, Gregory G.; Stern, Hal S.; Shahbaba, Babak

2013-01-01

We propose a hierarchical Bayesian model for analyzing multi-site experimental fMRI studies. Our method takes the hierarchical structure of the data (subjects are nested within sites, and there are multiple observations per subject) into account and allows for modeling between-site variation. Using posterior predictive model checking and model…

Spectroscopic observations with the Stratospheric Observatory for Infrared Astronomy (SOFIA)

NASA Astrophysics Data System (ADS)

Becklin, E. E.; Tielens, A. G. G. M.; Callis, H. H. S.

The joint US and German SOFIA project to develop and operate a 2.5-meter infrared airborne telescope in a Boeing 747-SP is now in its final stages of development. Flying in the stratosphere, SOFIA allows observations through the infrared and submillimeter region, with an average transmission of greater than 80%. SOFIA is characterized by a wide instrument complement ranging from broadband imagers, through moderate resolution spectrographs capable of resolving broad features due to dust and large molecules, to high-resolution spectrometers suitable for kinematic studies of molecular and atomic gas lines at km/s resolution. This broad range in instruments will enable SOFIA to make unique contributions to a broad array of science topics. First science flights will begin in 2009 and the observatory is expected to operate for over 20 years. The sensitivity, characteristics, science instrument complement, and examples of first light spectroscopic science are discussed.

The Growth of Multi-Site Fatigue Damage in Fuselage Lap Joints

NASA Technical Reports Server (NTRS)

Piascik, Robert S.; Willard, Scott A.

1999-01-01

Destructive examinations were performed to document the progression of multi-site damage (MSD) in three lap joint panels that were removed from a full scale fuselage test article that was tested to 60,000 full pressurization cycles. Similar fatigue crack growth characteristics were observed for small cracks (50 microns to 10 mm) emanating from counter bore rivets, straight shank rivets, and 100 deg counter sink rivets. Good correlation of the fatigue crack growth data base obtained in this study and FASTRAN Code predictions show that the growth of MSD in the fuselage lap joint structure can be predicted by fracture mechanics based methods.

Increasing the ranks of academic researchers in mental health: a multisite approach to postdoctoral fellowship training.

PubMed

O'Hara, Ruth; Cassidy-Eagle, Erin L; Beaudreau, Sherry A; Eyler, Lisa T; Gray, Heather L; Giese-Davis, Janine; Hubbard, Jeffrey; Yesavage, Jerome A

2010-01-01

This report highlights the use of multisite training for psychiatry and psychology postdoctoral fellows developing careers in academic clinical research in the field of mental health. The objective is to describe a model of training for young investigators to establish independent academic clinical research careers, including (1) program structure and eligibility, (2) program goals and development of a multisite curriculum, (3) use of technology for implementing the program across multiple sites, and (4) advantages and challenges of this multisite approach. In 2000, in collaboration with the Veterans Affairs (VA) Mental Illness Research, Education and Clinical Centers (MIRECCs), the VA Office of Academic Affiliations launched the Special Fellowship Program in Advanced Psychiatry and Psychology. Each of the 10 currently participating VA sites across the United States is affiliated with a MIRECC and an academic medical institution. In the first five years of this fellowship program, 83 fellows (34 psychiatrists and 49 psychologists) have participated. The success of this multisite approach is evidenced by the 58 fellows who have already graduated from the program: 70% have entered academic clinical research positions, and over 25 have obtained independent extramural grant support from the VA or the National Institutes of Health. Multisite training results in a greater transfer of knowledge and capitalizes on the nationwide availability of experts, creating unique networking and learning opportunities for trainees. The VA's multisite fellowship program plays a valuable role in preparing substantial numbers of psychiatry and psychology trainees for a range of academic clinical research and leadership positions in the field of mental health.

Submillimetric Spectroscopic Observations of Volatiles in Comet C-2004 Q2 (Machholz)

NASA Technical Reports Server (NTRS)

DeVal-Borro, M.; Hartogh, P.; Jarchow, C.; Rengel, M.; Villanueva, G. L.; Kueppers, M.; Biver, N.; Bockelee-Morvan, D.; Crovisier, J.

2012-01-01

Submillimeter spectroscopic observations of comets provide an important tool for understanding their chemical composition and enable a taxonomic classification. Aims. We aim to determine the production rates of several parent- and product volatiles and the C-12/C-13 isotopic carbon ratio in the long-period comet C/2004 Q2 (Machholz), which is likely to originate from the Oort Cloud. Methods. The line emission from several molecules in the coma was measured with high signal-to-noise ratio in January 2005 at heliocentric distance of 1.2 AU by means of high-resolution spectroscopic observations using the Submillimeter Telescope (SMT) at the Arizona Radio Observatory (ARO). Results. We have obtained production rates of several volatiles (CH3OH, HCN, H(sup 13)CN, HNC, H2CO, CO, and CS) by comparing the observed and simulated line-integrated intensities. We calculated the synthetic profiles using a radiative transfer code that includes collisions between neutrals and electrons, and the effects of radiative pumping of the fundamental vibrational levels by solar infrared radiation. Furthermore, multiline observations of the CH3OH J = 7-6 series allow us to estimate the rotational temperature using the rotation diagram technique. We find that the CH3OH population distribution of the levels sampled by these lines can be described by a rotational temperature of 40 +/- 3 K. Derived mixing ratios relative to hydrogen cyanide are CO/CH3OH/H2CO/CS/HNC/HC-13N/HCN= 30.9/24.6/4.8/0.57/0.031/0.013/1 assuming a pointing offset of 8" due to the uncertain ephemeris at the time of the observations and the telescope pointing error. Conclusions. The measured relative molecular abundances in C/2004 Q2 (Machholz) are between low- to typical values of those obtained in Oort Cloud comets, suggesting that it has visited the inner solar system previously and undergone thermal processing. The HNC/HCN abundance ratio of approx 3.1% is comparable to that found in other comets, accounting for the

Quantification of source impact to PM using three-dimensional weighted factor model analysis on multi-site data

NASA Astrophysics Data System (ADS)

Shi, Guoliang; Peng, Xing; Huangfu, Yanqi; Wang, Wei; Xu, Jiao; Tian, Yingze; Feng, Yinchang; Ivey, Cesunica E.; Russell, Armistead G.

2017-07-01

Source apportionment technologies are used to understand the impacts of important sources of particulate matter (PM) air quality, and are widely used for both scientific studies and air quality management. Generally, receptor models apportion speciated PM data from a single sampling site. With the development of large scale monitoring networks, PM speciation are observed at multiple sites in an urban area. For these situations, the models should account for three factors, or dimensions, of the PM, including the chemical species concentrations, sampling periods and sampling site information, suggesting the potential power of a three-dimensional source apportionment approach. However, the principle of three-dimensional Parallel Factor Analysis (Ordinary PARAFAC) model does not always work well in real environmental situations for multi-site receptor datasets. In this work, a new three-way receptor model, called "multi-site three way factor analysis" model is proposed to deal with the multi-site receptor datasets. Synthetic datasets were developed and introduced into the new model to test its performance. Average absolute error (AAE, between estimated and true contributions) for extracted sources were all less than 50%. Additionally, three-dimensional ambient datasets from a Chinese mega-city, Chengdu, were analyzed using this new model to assess the application. Four factors are extracted by the multi-site WFA3 model: secondary source have the highest contributions (64.73 and 56.24 μg/m3), followed by vehicular exhaust (30.13 and 33.60 μg/m3), crustal dust (26.12 and 29.99 μg/m3) and coal combustion (10.73 and 14.83 μg/m3). The model was also compared to PMF, with general agreement, though PMF suggested a lower crustal contribution.

High-dispersion infrared spectroscopic observations of comet 8P/Tuttle with VLT/CRIRES

NASA Astrophysics Data System (ADS)

Kobayashi, H.; Bockelée-Morvan, D.; Kawakita, H.; Dello Russo, N.; Jehin, E.; Manfroid, J.; Smette, A.; Hutsemékers, D.; Stüwe, J.; Weiler, M.; Arpigny, C.; Biver, N.; Cochran, A.; Crovisier, J.; Magain, P.; Sana, H.; Schulz, R.; Vervack, R. J.; Weaver, H.; Zucconi, J.-M.

2010-01-01

We report on the composition of the Halley-family comet (HFC) 8P/Tuttle investigated with high-dispersion near-infrared spectroscopic observations. The observations were carried out at the ESO VLT (Very Large Telescope) with the CRIRES instrument as part of a multi-wavelength observation campaign of 8P/Tuttle performed in late January and early February 2008. Radar observations suggested that 8P/Tuttle is a contact binary, and it was proposed that these components might be heterogeneous in chemistry. We determined mixing ratios of organic volatiles with respect to H2O and found that mixing ratios were consistent with previous near infrared spectroscopic observations obtained in late December 2007 and in late January 2008. It has been suggested that because 8P/Tuttle is a contact binary, it might be chemically heterogeneous. However, we find no evidence for chemical heterogeneity within the nucleus of 8P/Tuttle. We also compared the mixing ratios of organic molecules in 8P/Tuttle with those of both other HFCs and long period comets (LPCs) and found that HCN, C2H2, and C2H6 are depleted whereas CH4 and CH3OH have normal abundances. This may indicate that 8P/Tuttle was formed in a different region of the early solar nebula than other HFCs and LPCs. We estimated the conversion efficiency from C2H2 to C2H6 by hydrogen addition reactions on cold grains by employing the C2H6/(C2H6+C2H2) ratio. The C2H6/(C2H6+C2H2) ratio in 8P/Tuttle is consistent with the ratios found in other HFCs and LPCs within the error bars. We also discuss the source of C2 and CN based on our observations and conclude that the abundances of C2H2 and C2H6 are insufficient to explain the C2 abundances in comet 8P/Tuttle and that the abundance of HCN is insufficient to explain the CN abundances in the comet, so at least one additional parent is needed for each species, as pointed out in previous study. Based on observations collected at the European Southern Observatory, Paranal, Chile (ESO Prog. 080.C

Multi-site pain and working conditions as predictors of work ability in a 4-year follow-up among food industry employees.

PubMed

Neupane, S; Virtanen, P; Leino-Arjas, P; Miranda, H; Siukola, A; Nygård, C-H

2013-03-01

We investigated the separate and joint effects of multi-site musculoskeletal pain and physical and psychosocial exposures at work on future work ability. A survey was conducted among employees of a Finnish food industry company in 2005 (n = 1201) and a follow-up survey in 2009 (n = 734). Information on self-assessed work ability (current work ability on a scale from 0 to 10; 7 = poor work ability), multi-site musculoskeletal pain (pain in at least two anatomical areas of four), leisure-time physical activity, body mass index and physical and psychosocial exposures was obtained by questionnaire. The separate and joint effects of multi-site pain and work exposures on work ability at follow-up, among subjects with good work ability at baseline, were assessed by logistic regression, and p-values for the interaction derived. Compared with subjects with neither multi-site pain nor adverse work exposure, multi-site pain at baseline increased the risk of poor work ability at follow-up, allowing for age, gender, occupational class, body mass index and leisure-time physical activity. The separate effects of the work exposures on work ability were somewhat smaller than those of multi-site pain. Multi-site pain had an interactive effect with work environment and awkward postures, such that no association of multi-site pain with poor work ability was seen when work environment was poor or awkward postures present. The decline in work ability connected with multi-site pain was not increased by exposure to adverse physical or psychosocial factors at work. © 2012 European Federation of International Association for the Study of Pain Chapters.

Analysis Concerning the Inspection Threshold for Multi-Site Damage.

DOT National Transportation Integrated Search

1993-12-01

Periodic inspections, at a prescribed interval, for Multi-Site Damage (MS) in longitudinal fuselage lap-joints start when the aircraft has accumulated a certain number of flights, the inspection threshold. The work reported here was an attempt to obt...

Time-resolved FUSE photometric and spectroscopic observations: PG 1219+534, PG 1605+072, and PG 1613+426

NASA Astrophysics Data System (ADS)

Kuassivi; Bonanno, A.; Ferlet, R.

2005-11-01

We report the detection of pulsations in the far ultraviolet (FUV) light curves of PG 1219+534, PG 1605+072 and PG 1613+426 obtained with the Far Ultraviolet Spectroscopic Explorer (FUSE) in time tagged mode (TTAG). Exposures of the order of a few ksec were sufficient to observe the main frequencies of PG 1219+534 and PG 1605+072 and confirm the detection of a pulsation mode at the surface of PG 1613+426 as reported from ground. For the first time we derive time resolved spectroscopic FUSE data of a sdB pulsator (PG 1605+072) and comment on its line profile variation diagram (lpv diagram). We observe the phase shift between the maximum luminosity and the maximum radius to be consistent with the model of an adiabatic pulsator. We also present evidence that the line broadening previously reported is not caused by rotation but is rather an observational bias due to the rapid Doppler shift of the lines with 17 km s-1 amplitude. Thus our observations do not support the previous claim that PG 1605+072 is (or will evolve into) an unusually fast rotating degenerate dwarf. These results demonstrate the asteroseismological potential of the FUSE satellite which should be viewed as another powerful means of investigating stellar pulsations, along with the MOST and COROT missions.

Photometric and spectroscopic gamma-ray observations of solar transient phenomena using long duration balloons

NASA Technical Reports Server (NTRS)

Pelling, M. R.; Duttweiler, F.; Lin, R. F.; Levedahl, W. K.; Primbach, H.; Curtis, D. W.; Burley, K. C.

1985-01-01

A program currently in progress to conduct extended duration spectroscopic and photometric observation of solar X-ray phenomena from balloons is described. High photometric sensitivity to weak hard X-ray bursts is attained using a 600 sq cm array of phoswich scintillators. High spectral resolution for stronger bursts is available from an array of planar germanium detectors. These instruments are carried in a novel balloon gondola dssigned for the 15 to 20 day float durations available through using conventional zero pressure balloons in the radiation controlled (RACOON) mode.

Photometric and spectroscopic gamma-ray observations of solar transient phenomena using long duration balloons

NASA Astrophysics Data System (ADS)

Pelling, M. R.; Duttweiler, F.; Lin, R. F.; Levedahl, W. K.; Primbach, H.; Curtis, D. W.; Burley, K. C.

1985-08-01

A program currently in progress to conduct extended duration spectroscopic and photometric observation of solar X-ray phenomena from balloons is described. High photometric sensitivity to weak hard X-ray bursts is attained using a 600 sq cm array of phoswich scintillators. High spectral resolution for stronger bursts is available from an array of planar germanium detectors. These instruments are carried in a novel balloon gondola dssigned for the 15 to 20 day float durations available through using conventional zero pressure balloons in the radiation controlled (RACOON) mode.

The ability of multi-site, multi-depth sacral lateral branch blocks to anesthetize the sacroiliac joint complex.

PubMed

Dreyfuss, Paul; Henning, Troy; Malladi, Niriksha; Goldstein, Barry; Bogduk, Nikolai

2009-01-01

To determine the physiologic effectiveness of multi-site, multi-depth sacral lateral branch injections. Double-blind, randomized, placebo-controlled study. Outpatient pain management center. Twenty asymptomatic volunteers. The dorsal innervation to the sacroiliac joint (SIJ) is from the L5 dorsal ramus and the S1-3 lateral branches. Multi-site, multi-depth lateral branch blocks were developed to compensate for the complex regional anatomy that limited the effectiveness of single-site, single-depth lateral branch injections. Bilateral multi-site, multi-depth lateral branch green dye injections and subsequent dissection on two cadavers revealed a 91% accuracy with this technique. Session 1: 20 asymptomatic subjects had a 25-g spinal needle probe their interosseous (IO) and dorsal sacroiliac (DSI) ligaments. The inferior dorsal SIJ was entered and capsular distension with contrast medium was performed. Discomfort had to occur with each provocation maneuver and a contained arthrogram was necessary to continue in the study. Session 2: 1 week later; computer randomized, double-blind multi-site, multi-depth lateral branch blocks injections were performed. Ten subjects received active (bupivicaine 0.75%) and 10 subjects received sham (normal saline) multi-site, multi-depth lateral branch injections. Thirty minutes later, provocation testing was repeated with identical methodology used in session 1. Presence or absence of pain for ligamentous probing and SIJ capsular distension. Seventy percent of the active group had an insensate IO and DSI ligaments, and inferior dorsal SIJ vs 0-10% of the sham group. Twenty percent of the active vs 10% of the sham group did not feel repeat capsular distension. Six of seven subjects (86%) retained the ability to feel repeat capsular distension despite an insensate dorsal SIJ complex. Multi-site, multi-depth lateral branch blocks are physiologically effective at a rate of 70%. Multi-site, multi-depth lateral branch blocks do not

Efficient multi-site two-photon functional imaging of neuronal circuits.

PubMed

Castanares, Michael Lawrence; Gautam, Vini; Drury, Jack; Bachor, Hans; Daria, Vincent R

2016-12-01

Two-photon imaging using high-speed multi-channel detectors is a promising approach for optical recording of cellular membrane dynamics at multiple sites. A main bottleneck of this technique is the limited number of photons captured within a short exposure time (~1ms). Here, we implement temporal gating to improve the two-photon fluorescence yield from holographically projected multiple foci whilst maintaining a biologically safe incident average power. We observed up to 6x improvement in the signal-to-noise ratio (SNR) in Fluorescein and cultured hippocampal neurons showing evoked calcium transients. With improved SNR, we could pave the way to achieving multi-site optical recording of fluorogenic probes with response times in the order of ~1ms.

Implementation Considerations for Multisite Clinical Trials with Cognitive Neuroscience Tasks

PubMed Central

Keefe, Richard S. E.; Harvey, Philip D.

2008-01-01

Multisite clinical trials aimed at cognitive enhancement across various neuropsychiatric conditions have employed standard neuropsychological tests as outcome measures. While these tests have enjoyed wide clinical use and have proven reliable and predictive of functional disability, a number of implementation challenges have arisen when these tests are used in clinical trials. These issues are likely to be magnified in future studies when cognitive neuroscience (CN) procedures are explored in these trials, because in their current forms CN procedures are less standardized and more difficult to teach and monitor. For multisite trials, we anticipate that the most challenging issues will include assuring tester competence, monitoring tester performance, specific challenges with complex assessment methods, and having resources available for adequate monitoring of data quality. Suggestions for overcoming these implementation challenges are offered. PMID:18495645

How Does a Multi-Site Institution Plan Effectively?

ERIC Educational Resources Information Center

Jefferson, Curtis F.

A multi-site college plans effectively by having in place planning and evaluation systems that enhance its capability to respond effectively to changes in the environment in order to continue to provide high quality educational programs and services for the people in its service area. The effectiveness of these systems is dependent on clearly…

Photometric and Spectroscopic Observations of SN 2012dn, a Super-Chandra Candidate Type-Ia Supernova

NASA Astrophysics Data System (ADS)

Parrent, Jerod T.; Transient Factory, Palomar; Cumbres Observatory Global Telescope Network, Las

2013-01-01

Currently, there is no singular standard model picture of type-Ia supernovae (SNe Ia) with a parameter-space of predictions that overlap the observed, diverse array of SN Ia properties. The same can be said for the super-luminous versions of SNe Ia, those thought to originate from up to 2.4 solar mass progenitor systems. To make matters worse, we remain in the dark-ages of astronomy regarding the interpretation of their observed spectra. In short, line-blending due to resonant line-scattering alone prevents making clear the compositional makeup of the outermost ejected layers. Since simulations of violent merger and single degenerate scenarios are both able to roughly reproduce spectroscopic observations, the direct mapping of the ejecta via spectrum synthesis measurements is of high importance. For example, with the closest SN Ia to date, SN 2011fe, we were able to map (in velocity space) the composition of the outer layers of ejecta. We did this by evolving simple P-Cygni-blends of synthetic spectra over the course of the first month (post-explosion), with an average of 1.8 days between observations by which to compare. As a result, SN 2011fe gave a clearer picture of the compositional structure of a ''normal'' SN Ia. We now have another chance to put this measure of SN Ia diversity into practice with the discovery of a brighter than normal southern hemisphere object, SN 2012dn. Here we present g-, r-, and i-band photometric observations obtained at Faulkes Telescope South, as well as optical time-series spectra from Gemini-North, Gemini-South, SALT, and MMT facilities. With 19 spectroscopic observations spanning its first month, post-explosion, we are able to measure the relative velocities of the periodic table in the outermost layers of ejected material. This serves as a means for distinguishing the origin of SNe Ia and their various forms.

Replication and Comparison of the Newly Proposed ADOS-2, Module 4 Algorithm in ASD without ID: A Multi-Site Study

ERIC Educational Resources Information Center

Pugliese, Cara E.; Kenworthy, Lauren; Bal, Vanessa Hus; Wallace, Gregory L.; Yerys, Benjamin E.; Maddox, Brenna B.; White, Susan W.; Popal, Haroon; Armour, Anna Chelsea; Miller, Judith; Herrington, John D.; Schultz, Robert T.; Martin, Alex; Anthony, Laura Gutermuth

2015-01-01

Recent updates have been proposed to the Autism Diagnostic Observation Schedule-2 Module 4 diagnostic algorithm. This new algorithm, however, has not yet been validated in an independent sample without intellectual disability (ID). This multi-site study compared the original and revised algorithms in individuals with ASD without ID. The revised…

Supervision of Facilitators in a Multisite Study: Goals, Process, and Outcomes

PubMed Central

2010-01-01

Objective To describe the aims, implementation, and desired outcomes of facilitator supervision for both interventions (treatment and control) in Project Eban and to present the Eban Theoretical Framework for Supervision that guided the facilitators’ supervision. The qualifications and training of supervisors and facilitators are also described. Design This article provides a detailed description of supervision in a multisite behavioral intervention trial. The Eban Theoretical Framework for Supervision is guided by 3 theories: cognitive behavior therapy, the Life-long Model of Supervision, and “Empowering supervisees to empower others: a culturally responsive supervision model.” Methods Supervision is based on the Eban Theoretical Framework for Supervision, which provides guidelines for implementing both interventions using goals, process, and outcomes. Results Because of effective supervision, the interventions were implemented with fidelity to the protocol and were standard across the multiple sites. Conclusions Supervision of facilitators is a crucial aspect of multisite intervention research quality assurance. It provides them with expert advice, optimizes the effectiveness of facilitators, and increases adherence to the protocol across multiple sites. Based on the experience in this trial, some of the challenges that arise when conducting a multisite randomized control trial and how they can be handled by implementing the Eban Theoretical Framework for Supervision are described. PMID:18724192

Optical low-dispersion spectroscopic observations of Comet 103P/Hartley 2 at Koyama Astronomical Observatory during the EPOXI flyby

NASA Astrophysics Data System (ADS)

Shinnaka, Yoshiharu; Kawakita, Hideyo; Kobayashi, Hitomi; Naka, Chiharu; Arai, Akira; Arasaki, Takayuki; Kitao, Eiji; Taguchi, Gaku; Ikeda, Yuji

2013-02-01

We performed low-dispersion spectroscopic observations of Comet 103P/Hartley 2 in optical wavelengths using the LOSA/F2 mounted on the 1.3 m-Araki telescope at Koyama Astronomical Observatory on UT 2010 November 4 during the close approach of the Deep Impact spacecraft to the nucleus of Comet 103P/Hartley 2 in the EPOXI mission flyby. Our observations have revealed the chemistry of the coma at optical wavelengths; including CN, C3, C2 and NH2 along with H2O from [OI] emission at 6300 Å. Resultant mixing ratios of these radicals put the comet into the normal group in chemical composition. The mixing ratios with respect to H2O obtained in our observations are basically consistent with the previous optical spectro-photometric observations of Comet 103P/Hartley 2 in 1991 by A'Hearn et al. (A'Hearn, M.F., Millis, R.L., Schleicher, D.G., Osip, D.J., Birch, P.V. [1995]. Icarus 118, 223-270), the optical spectroscopic observations in 1998 by Fink (Fink, U. [2009]. Icarus 201, 311-334) and also consistent with the observations on UT 2010 October 27 and 29 by Lara et al. (Lara, L.M., Lin, Z.-Y., Meech, K. [2011]. Astron. Astrophys. 532, A87) (but only for the ratio relative to CN).

Multisite HPV16/18 Vaccine Efficacy Against Cervical, Anal, and Oral HPV Infection

PubMed Central

Kreimer, Aimée R.; Schiffman, Mark; Herrero, Rolando; Wacholder, Sholom; Rodriguez, Ana Cecilia; Lowy, Douglas R.; Porras, Carolina; Schiller, John T.; Quint, Wim; Jimenez, Silvia; Safaeian, Mahboobeh; Struijk, Linda; Schussler, John; Hildesheim, Allan; Gonzalez, Paula

2016-01-01

Background: Previous Costa Rica Vaccine Trial (CVT) reports separately demonstrated vaccine efficacy against HPV16 and HPV18 (HPV16/18) infections at the cervical, anal, and oral regions; however, the combined overall multisite efficacy (protection at all three sites) and vaccine efficacy among women infected with HPV16 or HPV18 prior to vaccination are less known. Methods: Women age 18 to 25 years from the CVT were randomly assigned to the HPV16/18 vaccine (Cervarix) or a hepatitis A vaccine. Cervical, oral, and anal specimens were collected at the four-year follow-up visit from 4186 women. Multisite and single-site vaccine efficacies (VEs) and 95% confidence intervals (CIs) were computed for one-time detection of point prevalent HPV16/18 in the cervical, anal, and oral regions four years after vaccination. All statistical tests were two-sided. Results: The multisite woman-level vaccine efficacy was highest among “naïve” women (HPV16/18 seronegative and cervical HPV high-risk DNA negative at vaccination) (vaccine efficacy = 83.5%, 95% CI = 72.1% to 90.8%). Multisite woman-level vaccine efficacy was also demonstrated among women with evidence of a pre-enrollment HPV16 or HPV18 infection (seropositive for HPV16 and/or HPV18 but cervical HPV16/18 DNA negative at vaccination) (vaccine efficacy = 57.8%, 95% CI = 34.4% to 73.4%), but not in those with cervical HPV16 and/or HPV18 DNA at vaccination (anal/oral HPV16/18 VE = 25.3%, 95% CI = -40.4% to 61.1%). Concordant HPV16/18 infections at two or three sites were also less common in HPV16/18-infected women in the HPV vaccine vs control arm (7.4% vs 30.4%, P < .001). Conclusions: This study found high multisite vaccine efficacy among “naïve” women and also suggests the vaccine may provide protection against HPV16/18 infections at one or more anatomic sites among some women infected with these types prior to HPV16/18 vaccination. PMID:26467666

Progress in centralised ethics review processes: Implications for multi-site health evaluations.

PubMed

Prosser, Brenton; Davey, Rachel; Gibson, Diane

2015-04-01

Increasingly, public sector programmes respond to complex social problems that intersect specific fields and individual disciplines. Such responses result in multi-site initiatives that can span nations, jurisdictions, sectors and organisations. The rigorous evaluation of public sector programmes is now a baseline expectation. For evaluations of large and complex multi-site programme initiatives, the processes of ethics review can present a significant challenge. However in recent years, there have been new developments in centralised ethics review processes in many nations. This paper provides the case study of an evaluation of a national, inter-jurisdictional, cross-sector, aged care health initiative and its encounters with Australian centralised ethics review processes. Specifically, the paper considers progress against the key themes of a previous five-year, five nation study (Fitzgerald and Phillips, 2006), which found that centralised ethics review processes would save time, money and effort, as well as contribute to more equitable workloads for researchers and evaluators. The paper concludes with insights for those charged with refining centralised ethics review processes, as well as recommendations for future evaluators of complex multi-site programme initiatives. Copyright © 2015 Elsevier Ltd. All rights reserved.

Berkeley Supernova Ia Program - I. Observations, data reduction and spectroscopic sample of 582 low-redshift Type Ia supernovae

NASA Astrophysics Data System (ADS)

Silverman, Jeffrey M.; Foley, Ryan J.; Filippenko, Alexei V.; Ganeshalingam, Mohan; Barth, Aaron J.; Chornock, Ryan; Griffith, Christopher V.; Kong, Jason J.; Lee, Nicholas; Leonard, Douglas C.; Matheson, Thomas; Miller, Emily G.; Steele, Thea N.; Barris, Brian J.; Bloom, Joshua S.; Cobb, Bethany E.; Coil, Alison L.; Desroches, Louis-Benoit; Gates, Elinor L.; Ho, Luis C.; Jha, Saurabh W.; Kandrashoff, Michael T.; Li, Weidong; Mandel, Kaisey S.; Modjaz, Maryam; Moore, Matthew R.; Mostardi, Robin E.; Papenkova, Marina S.; Park, Sung; Perley, Daniel A.; Poznanski, Dovi; Reuter, Cassie A.; Scala, James; Serduke, Franklin J. D.; Shields, Joseph C.; Swift, Brandon J.; Tonry, John L.; Van Dyk, Schuyler D.; Wang, Xiaofeng; Wong, Diane S.

2012-09-01

In this first paper in a series, we present 1298 low-redshift (z ≲ 0.2) optical spectra of 582 Type Ia supernovae (SNe Ia) observed from 1989 to 2008 as part of the Berkeley Supernova Ia Program (BSNIP). 584 spectra of 199 SNe Ia have well-calibrated light curves with measured distance moduli, and many of the spectra have been corrected for host-galaxy contamination. Most of the data were obtained using the Kast double spectrograph mounted on the Shane 3 m telescope at Lick Observatory and have a typical wavelength range of 3300-10 400 Å, roughly twice as wide as spectra from most previously published data sets. We present our observing and reduction procedures, and we describe the resulting SN Database, which will be an online, public, searchable data base containing all of our fully reduced spectra and companion photometry. In addition, we discuss our spectral classification scheme (using the SuperNova IDentification code, SNID; Blondin & Tonry), utilizing our newly constructed set of SNID spectral templates. These templates allow us to accurately classify our entire data set, and by doing so we are able to reclassify a handful of objects as bona fide SNe Ia and a few other objects as members of some of the peculiar SN Ia subtypes. In fact, our data set includes spectra of nearly 90 spectroscopically peculiar SNe Ia. We also present spectroscopic host-galaxy redshifts of some SNe Ia where these values were previously unknown. The sheer size of the BSNIP data set and the consistency of our observation and reduction methods make this sample unique among all other published SN Ia data sets and complementary in many ways to the large, low-redshift SN Ia spectra presented by Matheson et al. and Blondin et al. In other BSNIP papers in this series, we use these data to examine the relationships between spectroscopic characteristics and various observables such as photometric and host-galaxy properties.

The interpretation of simultaneous soft X-ray spectroscopic and imaging observations of an active region. [in solar corona

NASA Technical Reports Server (NTRS)

Davis, J. M.; Gerassimenko, M.; Krieger, A. S.; Vaiana, G. S.

1975-01-01

Simultaneous soft X-ray spectroscopic and broad-band imaging observations of an active region have been analyzed together to determine the parameters which describe the coronal plasma. From the spectroscopic data, models of temperature-emission measure-elemental abundance have been constructed which provide acceptable statistical fits. By folding these possible models through the imaging analysis, models which are not self-consistent can be rejected. In this way, only the oxygen, neon, and iron abundances of Pottasch (1967), combined with either an isothermal or exponential temperature-emission-measure model, are consistent with both sets of data. Contour maps of electron temperature and density for the active region have been constructed from the imaging data. The implications of the analysis for the determination of coronal abundances and for future satellite experiments are discussed.

New spectroscopic and photometric observations of CV J0644+3344

NASA Astrophysics Data System (ADS)

Hernández Santisteban, J. V.

We report photometric and simultaneous spectroscopic observations of the cataclysmic variable J0644+3344 and present calibrated Doppler tomography results of the object. We have calibrated the spectra for slit losses using simultaneous photometry. This has been used to construct reliable Doppler images in the Halpha , Hbeta and He II 4686 Å@ emission lines. We have also performed a radial velocity analysis using these emission lines to derive the primary semi-amplitude and used a cophasing method to determine the secondary K_2 best value. We have improved the ephemeris of the object based on the published and our new photometric eclipse timings to obtain HJD=254474.7927+0.26937446E. We derived a K_1=123.2±6.6 {km s}-1 and K_2=205.4±6.7. Assuming a i>76, the orbital parameters are M_1=0.91±0.04 M⊙, M_2=0.83±0.04 M⊙ and a=2.10±0.03 R⊙. Based on the Doppler tomography we conclude that J0644+3344 is a nova-like SW Sex type system.

Near-Simultaneous Spectroscopic and Broadband Polarimetric Observations of Be Stars

NASA Technical Reports Server (NTRS)

Ghosh, K.; Iyengar, K. V. K.; Ramsey, B. D.; Austin, R. A.

1999-01-01

Near simultaneous optical spectroscopic (on four nights) and broadband linear continuum (B, V, R, and I bands) polarimetric (on seven nights) observations of 29 Be stars were carried out during 1993 November-December. The program Be stars displayed wavelength dependence of intrinsic polarizations with no frequency dependence of polarimetric position angles. Some of the Be stars displayed long-term polarization variability. The Be and Be-shell stars could not be distinguished from one another solely on the basis of their polarization values. Full widths at half-maximum of the H.alpha profiles and the intrinsic linear continuum polarizations are closely correlated with the projected rotational velocities of the program stars. Photospheric-absorption-corrected equivalent widths of H.alpha profiles [W(alpha)] and the radii of H.alpha-emitting or -absorbing envelopes (R(sub e) or R(sub a)) are nonlinearly correlated with the intrinsic continuum polarizations of these stars. However, W(alpha) and R(sub e) are linearly correlated. With large uncertainties, there is a trend of spectral dependence of polarization. Detailed discussion of these results is presented in this paper.

Efficient multi-site two-photon functional imaging of neuronal circuits

PubMed Central

Castanares, Michael Lawrence; Gautam, Vini; Drury, Jack; Bachor, Hans; Daria, Vincent R.

2016-01-01

Two-photon imaging using high-speed multi-channel detectors is a promising approach for optical recording of cellular membrane dynamics at multiple sites. A main bottleneck of this technique is the limited number of photons captured within a short exposure time (~1ms). Here, we implement temporal gating to improve the two-photon fluorescence yield from holographically projected multiple foci whilst maintaining a biologically safe incident average power. We observed up to 6x improvement in the signal-to-noise ratio (SNR) in Fluorescein and cultured hippocampal neurons showing evoked calcium transients. With improved SNR, we could pave the way to achieving multi-site optical recording of fluorogenic probes with response times in the order of ~1ms. PMID:28018745

Use of personal digital assistants for data collection in a multi-site AIDS stigma study in rural south Nyanza, Kenya.

PubMed

Onono, M A; Carraher, N; Cohen, R C; Bukusi, E A; Turan, J M

2011-09-01

To describe the development, cost effectiveness and implementation of a PDA based electronic system to collect, verify and manage data from a multi-site study on HIV/AIDS stigma and pregnancy in a rural, resource-poor area. We worked within a large prevention of mother-to-child-transmission (PMTCT) program in nine rural health facilities to implement a PDA-based data collection system and to study the feasibility of its use in a multisite HIV research study in rural Kenya. The PDAs were programmed for collecting screening and eligibility data, and responses to structured interviews on HIV/AIDS stigma and violence in three local languages. Between November 2007 and December 2008, nine PDAs were used by Clinic and Community Health Assistants to enrol 1,270 participants on to the PMTCT program. Successes included: capacity-building of interviewers, low cost of implementation, quick turnaround time of data entry with good data quality, and convenience. Our study demonstrated the feasibility of utilizing PDAs for data collection in a multi-site observational study on HIV/AIDS stigma conducted in remote rural health facilities in Kenya. However, appropriate and frequent data backup protocols need to be established and paper forms are still needed as backup tools in resource-poor settings.

A DVD Spectroscope: A Simple, High-Resolution Classroom Spectroscope

ERIC Educational Resources Information Center

Wakabayashi, Fumitaka; Hamada, Kiyohito

2006-01-01

Digital versatile disks (DVDs) have successfully made up an inexpensive but high-resolution spectroscope suitable for classroom experiments that can easily be made with common material and gives clear and fine spectra of various light sources and colored material. The observed spectra can be photographed with a digital camera, and such images can…

Evaluation of spectroscopic databases through radiative transfer simulations compared to observations. Application to the validation of GEISA 2015 with IASI and TCCON

NASA Astrophysics Data System (ADS)

Armante, Raymond; Scott, Noelle; Crevoisier, Cyril; Capelle, Virginie; Crepeau, Laurent; Jacquinet, Nicole; Chédin, Alain

2016-09-01

The quality of spectroscopic parameters that serve as input to forward radiative transfer models are essential to fully exploit remote sensing of Earth atmosphere. However, the process of updating spectroscopic databases in order to provide the users with a database that insures an optimal characterization of spectral properties of molecular absorption for radiative transfer modeling is challenging. The evaluation of the databases content and the underlying choices made by the managing team is thus a crucial step. Here, we introduce an original and powerful approach for evaluating spectroscopic parameters: the Spectroscopic Parameters And Radiative Transfer Evaluation (SPARTE) chain. The SPARTE chain relies on the comparison between forward radiative transfer simulations made by the 4A radiative transfer model and observations of spectra made from various observations collocated over several thousands of well-characterized atmospheric situations. Averaging the resulting 'calculated-observed spectral' residuals minimizes the random errors coming from both the radiometric noise of the instruments and the imperfect description of the atmospheric state. The SPARTE chain can be used to evaluate any spectroscopic databases, from the visible to the microwave, using any type of remote sensing observations (ground-based, airborne or space-borne). We show that the comparison of the shape of the residuals enables: (i) identifying incorrect line parameters (line position, intensity, width, pressure shift, etc.), even for molecules for which interferences between the lines have to be taken into account; (ii) proposing revised values, in cooperation with contributing teams; and (iii) validating the final updated parameters. In particular, we show that the simultaneous availability of two databases such as GEISA and HITRAN helps identifying remaining issues in each database. The SPARTE chain has been here applied to the validation of the update of GEISA-2015 in 2 spectral regions

A Multisite Evaluation of Reading Is Fundamental: Summary Report.

ERIC Educational Resources Information Center

Parker, Ronald K.; And Others

Reading Is Fundamental (RIF) is a national program that seeks to motivate children to read. Implemented by local sponsors and aimed at disadvantaged groups, it offers participating children a wide selection of attractive paperback books about interesting people, places, and events. The multisite evaluation summarized in this report studied…

A Multisite Evaluation of Reading Is Fundamental: Technical Report.

ERIC Educational Resources Information Center

Parker, Ronald K.; And Others

Reading Is Fundamental (RIF) is a national program that seeks to motivate children to read. Implemented by local sponsors and aimed at disadvantaged groups, it offers participating children a wide selection of attractive paperbound books about interesting people, places, and events. The multisite evaluation discussed in this technical report…

High prevalence of daily and multi-site pain – a cross-sectional population-based study among 3000 Danish adolescents

PubMed Central

2013-01-01

Background Daily pain and multi-site pain are both associated with reduction in work ability and health-related quality of life (HRQoL) among adults. However, no population-based studies have yet investigated the prevalence of daily and multi-site pain among adolescents and how these are associated with respondent characteristics. The purpose of this study was to investigate the prevalence of self-reported daily and multi-site pain among adolescents aged 12–19 years and associations of almost daily pain and multi-site pain with respondent characteristics (sex, age, body mass index, HRQoL and sports participation). Methods A population-based cross-sectional study was conducted among 4,007 adolescents aged 12–19 years in Denmark. Adolescents answered an online questionnaire during physical education lessons. The questionnaire contained a mannequin divided into 12 regions on which the respondents indicated their current pain sites and pain frequency (rarely, monthly, weekly, more than once per week, almost daily pain), characteristics, sports participation and HRQoL measured by the EuroQoL 5D. Multivariate regression was used to calculate the odds ratio for the association between almost daily pain, multi-site pain and respondent characteristics. Results The response rate was 73.7%. A total of 2,953 adolescents (62% females) answered the questionnaire. 33.3% reported multi-site pain (pain in >1 region) while 19.8% reported almost daily pain. 61% reported current pain in at least one region with knee and back pain being the most common sites. Female sex (OR: 1.35-1.44) and a high level of sports participation (OR: 1.51-2.09) were associated with increased odds of having almost daily pain and multi-site pain. Better EQ-5D score was associated with decreased odds of having almost daily pain or multi-site pain (OR: 0.92-0.94). Conclusion In this population-based cohort of school-attending Danish adolescents, nearly two out of three reported current pain and, on

Biological stress systems, adverse life events and the onset of chronic multisite musculoskeletal pain: a 6-year cohort study.

PubMed

Generaal, Ellen; Vogelzangs, Nicole; Macfarlane, Gary J; Geenen, Rinie; Smit, Johannes H; de Geus, Eco J C N; Penninx, Brenda W J H; Dekker, Joost

2016-05-01

Dysregulated biological stress systems and adverse life events, independently and in interaction, have been hypothesised to initiate chronic pain. We examine whether (1) function of biological stress systems, (2) adverse life events, and (3) their combination predict the onset of chronic multisite musculoskeletal pain. Subjects (n=2039) of the Netherlands Study of Depression and Anxiety, free from chronic multisite musculoskeletal pain at baseline, were identified using the Chronic Pain Grade Questionnaire and followed up for the onset of chronic multisite musculoskeletal pain over 6 years. Baseline assessment of biological stress systems comprised function of the hypothalamic-pituitary-adrenal axis (1-h cortisol awakening response, evening levels, postdexamethasone levels), the immune system (basal and lipopolysaccharide-stimulated inflammation) and the autonomic nervous system (heart rate, pre-ejection period, SD of the normal-to-normal interval, respiratory sinus arrhythmia). The number of recent adverse life events was assessed at baseline using the List of Threatening Events Questionnaire. Hypothalamic-pituitary-adrenal axis, immune system and autonomic nervous system functioning was not associated with onset of chronic multisite musculoskeletal pain, either by itself or in interaction with adverse life events. Adverse life events did predict onset of chronic multisite musculoskeletal pain (HR per event=1.14, 95% CI 1.04 to 1.24, p=0.005). This longitudinal study could not confirm that dysregulated biological stress systems increase the risk of developing chronic multisite musculoskeletal pain. Adverse life events were a risk factor for the onset of chronic multisite musculoskeletal pain, suggesting that psychosocial factors play a role in triggering the development of this condition. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

Safety and Clinical Activity of Pembrolizumab and Multisite Stereotactic Body Radiotherapy in Patients With Advanced Solid Tumors.

PubMed

Luke, Jason J; Lemons, Jeffrey M; Karrison, Theodore G; Pitroda, Sean P; Melotek, James M; Zha, Yuanyuan; Al-Hallaq, Hania A; Arina, Ainhoa; Khodarev, Nikolai N; Janisch, Linda; Chang, Paul; Patel, Jyoti D; Fleming, Gini F; Moroney, John; Sharma, Manish R; White, Julia R; Ratain, Mark J; Gajewski, Thomas F; Weichselbaum, Ralph R; Chmura, Steven J

2018-02-13

Purpose Stereotactic body radiotherapy (SBRT) may stimulate innate and adaptive immunity to augment immunotherapy response. Multisite SBRT is an emerging paradigm for treating metastatic disease. Anti-PD-1-treatment outcomes may be improved with lower disease burden. In this context, we conducted a phase I study to evaluate the safety of pembrolizumab with multisite SBRT in patients with metastatic solid tumors. Patients and Methods Patients progressing on standard treatment received SBRT to two to four metastases. Not all metastases were targeted, and metastases > 65 mL were partially irradiated. SBRT dosing varied by site and ranged from 30 to 50 Gy in three to five fractions with predefined dose de-escalation if excess dose-limiting toxicities were observed. Pembrolizumab was initiated within 7 days after completion of SBRT. Pre- and post-SBRT biopsy specimens were analyzed in a subset of patients to quantify interferon-γ-induced gene expression. Results A total of 79 patients were enrolled; three patients did not receive any treatment and three patients only received SBRT. Patients included in the analysis were treated with SBRT and at least one cycle of pembrolizumab. Most (94.5%) of patients received SBRT to two metastases. Median follow-up for toxicity was 5.5 months (interquartile range, 3.3 to 8.1 months). Six patients experienced dose-limiting toxicities with no radiation dose reductions. In the 68 patients with imaging follow-up, the overall objective response rate was 13.2%. Median overall survival was 9.6 months (95% CI, 6.5 months to undetermined) and median progression-free survival was 3.1 months (95% CI, 2.9 to 3.4 months). Expression of interferon-γ-associated genes from post-SBRT tumor biopsy specimens significantly correlated with nonirradiated tumor response. Conclusion Multisite SBRT followed by pembrolizumab was well tolerated with acceptable toxicity. Additional studies exploring the clinical benefit and predictive biomarkers of combined

Solar Flares Observed with the Ramaty High Energy Solar Spectroscopic Imager (RHESSI)

NASA Technical Reports Server (NTRS)

Holman, Gordon D.

2004-01-01

Solar flares are impressive examples of explosive energy release in unconfined, magnetized plasma. It is generally believed that the flare energy is derived from the coronal magnetic field. However, we have not been able to establish the specific energy release mechanism(s) or the relative partitioning of the released energy between heating, particle acceleration (electrons and ions), and mass motions. NASA's RHESSI Mission was designed to study the acceleration and evolution of electrons and ions in flares by observing the X-ray and gamma-ray emissions these energetic particles produce. This is accomplished through the combination of high-resolution spectroscopy and spectroscopic imaging, including the first images of flares in gamma rays. RHESSI has observed over 12,000 solar flares since its launch on February 5, 2002. I will demonstrate how we use the RHESSI spectra to deduce physical properties of accelerated electrons and hot plasma in flares. Using images to estimate volumes, w e typically find that the total energy in accelerated electrons is comparable to that in the thermal plasma. I will also present flare observations that provide strong support for the presence of magnetic reconnection in a large-scale, vertical current sheet in the solar corona. RHESSI observations such as these are allowing us to probe more deeply into the physics of solar flares.

How Institutional and University Counselor Policies Effectively Respond to Victims of Cyber Violent Acts: A Multisite Case Study

ERIC Educational Resources Information Center

Richards, Gretchen M.

2012-01-01

This multisite case study examined how institutional and university counselor policies effectively respond to cyber violent acts. Stake's (2006) multisite case study methodology was used to identify seven themes from current literature. Two sites with four participants were selected. The participants included two counseling directors and the…

Real-Time Enrollment Dashboard For Multisite Clinical Trials.

PubMed

Mattingly, William A; Kelley, Robert R; Wiemken, Timothy L; Chariker, Julia H; Peyrani, Paula; Guinn, Brian E; Binford, Laura E; Buckner, Kimberley; Ramirez, Julio

2015-10-30

Achieving patient recruitment goals are critical for the successful completion of a clinical trial. We designed and developed a web-based dashboard for assisting in the management of clinical trial screening and enrollment. We use the dashboard to assist in the management of two observational studies of community-acquired pneumonia. Clinical research associates and managers using the dashboard were surveyed to determine its effectiveness as compared with traditional direct communication. The dashboard has been in use since it was first introduced in May of 2014. Of the 23 staff responding to the survey, 77% felt that it was easier or much easier to use the dashboard for communication than to use direct communication. We have designed and implemented a visualization dashboard for managing multi-site clinical trial enrollment in two community acquired pneumonia studies. Information dashboards are a useful tool for clinical trial management. They can be used as a standalone trial information tool or included into a larger management system.

Reduced hypothalamic-pituitary-adrenal axis activity in chronic multi-site musculoskeletal pain: partly masked by depressive and anxiety disorders.

PubMed

Generaal, Ellen; Vogelzangs, Nicole; Macfarlane, Gary J; Geenen, Rinie; Smit, Johannes H; Penninx, Brenda W J H; Dekker, Joost

2014-07-09

Studies on hypothalamic-pituitary-adrenal axis (HPA-axis) function amongst patients with chronic pain show equivocal results and well-controlled cohort studies are rare in this field. The goal of our study was to examine whether HPA-axis dysfunction is associated with the presence and the severity of chronic multi-site musculoskeletal pain. Data are from the Netherlands Study of Depression and Anxiety including 1125 subjects with and without lifetime depressive and anxiety disorders. The Chronic Pain Grade questionnaire was used to determine the presence and severity of chronic multi-site musculoskeletal pain. Subjects were categorized into a chronic multi-site musculoskeletal pain group (n = 471) and a control group (n = 654). Salivary cortisol samples were collected to assess HPA-axis function (awakening level, 1-h awakening response, evening level, diurnal slope and post-dexamethasone level). In comparison with the control group, subjects with chronic multi-site musculoskeletal pain showed significantly lower cortisol level at awakening, lower evening level and a blunted diurnal slope. Lower cortisol level at awakening and a blunted diurnal slope appeared to be restricted to those without depressive and/or anxiety disorders, who also showed a lower 1-h awakening response. Our results suggest hypocortisolemia in chronic multi-site musculoskeletal pain. However, if chronic pain is accompanied by a depressive or anxiety disorder, typically related to hypercortisolemia, the association between cortisol levels and chronic multi-site musculoskeletal pain appears to be partly masked. Future studies should take psychopathology into account when examining HPA-axis function in chronic pain.

Reduced hypothalamic-pituitary-adrenal axis activity in chronic multi-site musculoskeletal pain: partly masked by depressive and anxiety disorders

PubMed Central

2014-01-01

Background Studies on hypothalamic-pituitary-adrenal axis (HPA-axis) function amongst patients with chronic pain show equivocal results and well-controlled cohort studies are rare in this field. The goal of our study was to examine whether HPA-axis dysfunction is associated with the presence and the severity of chronic multi-site musculoskeletal pain. Methods Data are from the Netherlands Study of Depression and Anxiety including 1125 subjects with and without lifetime depressive and anxiety disorders. The Chronic Pain Grade questionnaire was used to determine the presence and severity of chronic multi-site musculoskeletal pain. Subjects were categorized into a chronic multi-site musculoskeletal pain group (n = 471) and a control group (n = 654). Salivary cortisol samples were collected to assess HPA-axis function (awakening level, 1-h awakening response, evening level, diurnal slope and post-dexamethasone level). Results In comparison with the control group, subjects with chronic multi-site musculoskeletal pain showed significantly lower cortisol level at awakening, lower evening level and a blunted diurnal slope. Lower cortisol level at awakening and a blunted diurnal slope appeared to be restricted to those without depressive and/or anxiety disorders, who also showed a lower 1-h awakening response. Conclusions Our results suggest hypocortisolemia in chronic multi-site musculoskeletal pain. However, if chronic pain is accompanied by a depressive or anxiety disorder, typically related to hypercortisolemia, the association between cortisol levels and chronic multi-site musculoskeletal pain appears to be partly masked. Future studies should take psychopathology into account when examining HPA-axis function in chronic pain. PMID:25007969

Resolving Spectral Lines with a Periscope-Type DVD Spectroscope

ERIC Educational Resources Information Center

Wakabayashi, Fumitaka

2008-01-01

A new type of DVD spectroscope, the periscope type, is described and the numerical analysis of the observed emission and absorption spectra is demonstrated. A small and thin mirror is put inside and an eighth part of a DVD is used as a grating. Using this improved DVD spectroscope, one can observe and photograph visible spectra more easily and…

Multi-Sited Ethnography and the Field of Educational Research

ERIC Educational Resources Information Center

Pierides, Dean

2010-01-01

This paper responds to the challenge of how educational research might be practised in a contemporary world that is no longer necessarily organised by nearness and unity. Focusing on ethnography, it argues for what a multi-sited imaginary contributes to research in the field of education. By giving prominence to the notion of multi-sited…

Estimation of future flow regime for a spatially varied Himalayan watershed using improved multi-site calibration method of SWAT model.

NASA Astrophysics Data System (ADS)

Pradhanang, S. M.; Hasan, M. A.; Booth, P.; Fallatah, O.

2016-12-01

The monsoon and snow driven regime in the Himalayan region has received increasing attention in the recent decade regarding the effects of climate change on hydrologic regimes. Modeling streamflow in such spatially varied catchment requires proper calibration and validation in hydrologic modeling. While calibration and validation are time consuming and computationally intensive, an effective regionalized approach with multi-site information is crucial for flow estimation, especially in daily scale. In this study, we adopted a multi-site approach to calibration and validation of the Soil Water Assessment Tool (SWAT) model for the Karnali river catchment, which is characterized as being the most vulnerable catchment to climate change in the Himalayan region. APHRODITE's (Asian Precipitation - Highly-Resolved Observational Data Integration Towards Evaluation) daily gridded precipitation data, one of the accurate and reliable weather date over this region were utilized in this study. The model evaluation of the entire catchment divided into four sub-catchments, utilizing discharge records from 1963 to 2010. In previous studies, multi-site calibration used only a single set of calibration parameters for all sub-catchment of a large watershed. In this study, we introduced a technique that can incorporate different sets of calibration parameters for each sub-basin, which eventually ameliorate the flow of the whole watershed. Results show that the calibrated model with new method can capture almost identical pattern of flow over the region. The predicted daily streamflow matched the observed values, with a Nash-Sutcliffe coefficient of 0.73 during calibration and 0.71 during validation period. The method perfumed better than existing multi-site calibration methods. To assess the influence of continued climate change on hydrologic processes, we modified the weather inputs for the model using precipitation and temperature changes for two Representative Concentration Pathways

Observation of Frenkel and charge transfer excitons in pentacene single crystals using spectroscopic generalized ellipsometry

NASA Astrophysics Data System (ADS)

Qi, Dongchen; Su, Haibin; Bastjan, M.; Jurchescu, O. D.; Palstra, T. M.; Wee, Andrew T. S.; Rübhausen, M.; Rusydi, A.

2013-09-01

We report on the emerging and admixture of Frenkel and charge transfer (CT) excitons near the absorption onset in pentacene single crystals. Using high energy-resolution spectroscopic generalized ellipsometry with in-plane polarization dependence, the excitonic nature of three lowest lying excitations is discussed. Their distinct polarization dependence strongly indicates the presence of both Frenkel and CT types of excitons near the excitation onset. In particular, the peculiar polarization behavior of the second excitation can only be rationalized by taking into account the inherent CT transition dipole moment. This observation has important implications for the pentacene-based optoelectronic devices.

Reliability of instruments in a cooperative, multisite study: employment intervention demonstration program.

PubMed

Salyers, M P; McHugo, G J; Cook, J A; Razzano, L A; Drake, R E; Mueser, K T

2001-09-01

Reliability of well-known instruments was examined in 202 people with severe mental illness participating in a multisite vocational study. We examined interrater reliability of the Positive and Negative Syndrome Scale (PANSS) and the internal consistency and test-retest reliability of the PANSS, the Rosenberg Self-Esteem Scale, the Medical Outcomes Study Short Form-36 (SF-36), and the Quality of Life Interview. Most scales had good levels of reliability, with intraclass correlation coefficients (ICCs) and coefficient alphas above .70. However, the SF-36 scales were generally less stable over time, particularly Social Functioning (ICC = .55). Test-retest reliability was lower among less educated respondents and among ethnic minorities. We recommend close monitoring of psychometric issues in future multisite studies.

From Controlled Trial to Community Adoption: The Multisite Translational Community Trial

PubMed Central

Murimi, Mary; Gonzalez, Anjelica; Njike, Valentine; Green, Lawrence W.

2011-01-01

Methods for translating the findings of controlled trials, such as the Diabetes Prevention Program, into real-world community application have not been clearly defined. A standardized research methodology for making and evaluating such a transition is needed. We introduce the multisite translational community trial (mTCT) as the research analog to the multisite randomized controlled trial. The mTCT is adapted to incorporate the principles and practices of community-based participatory research and the increased relevance and generalizability gained from diverse community settings. The mTCT is a tool designed to bridge the gap between what a clinical trial demonstrates can work in principle and what is needed to make it workable and effective in real-world settings. Its utility could be put to the test, in particular with practice-based research networks such as the Prevention Research Centers. PMID:21680935

A P&T Committee's Transition to a Complete Electronic Meeting System-A Multisite Institution Experience.

PubMed

Al-Jedai, Ahmed H; Algain, Roaa A; Alghamidi, Said A; Al-Jazairi, Abdulrazaq S; Amin, Rashid; Bin Hussain, Ibrahim Z

2017-10-01

In the last few decades, changes to formulary management processes have taken place in institutions with closed formulary systems. However, many P&T committees continued to operate using traditional paper-based systems. Paper-based systems have many limitations, including confidentiality, efficiency, open voting, and paper wastage. This becomes more challenging when dealing with a multisite P&T committee that handles formulary matters across the whole health care system. In this paper, we discuss the implementation of the first paperless, completely electronic, Web-based formulary management system across a large health care system in the Middle East. We describe the transitioning of a multisite P&T committee in a large tertiary care institution from a paper-based to an all-electronic system. The challenges and limitations of running a multisite P&T committee utilizing a paper system are discussed. The design and development of a Web-based committee floor management application that can be used from notebooks, tablets, and hand-held devices is described. Implementation of a flexible, interactive, easy-to-use, and efficient electronic formulary management system is explained in detail. The development of an electronic P&T committee meeting system that encompasses electronic document sharing, voting, and communication could help multisite health care systems unify their formularies across multiple sites. Our experience might not be generalizable to all institutions because this depends heavily on system features, existing processes and workflow, and implementation across different sites.

Detection of High-Frequency Oscillations and Damping from Multi-slit Spectroscopic Observations of the Corona

NASA Astrophysics Data System (ADS)

Samanta, T.; Singh, J.; Sindhuja, G.; Banerjee, D.

2016-01-01

During the total solar eclipse of 11 July 2010, multi-slit spectroscopic observations of the solar corona were performed from Easter Island, Chile. To search for high-frequency waves, observations were taken at a high cadence in the green line at 5303 Å that is due to [Fe xiv] and the red line at 6374 Å that is due to [Fe x]. The data were analyzed to study the periodic variations in intensity, Doppler velocity, and line width using wavelet analysis. The data with high spectral and temporal resolution enabled us to study the rapid dynamical changes within coronal structures. We find that at certain locations, each parameter shows significant oscillation with periods ranging from 6 - 25 s. For the first time, we were able to detect damping of high-frequency oscillations with periods of about 10 s. If the observed damped oscillations are due to magnetohydrodynamic waves, then they can contribute significantly to the heating of the corona. From a statistical study we try to characterize the nature of the observed oscillations while considering the distribution of power in different line parameters.

Multi-site Observations of Pulsation in the Accreting White Dwarf SDSS J161033.64-010223.3 (V386 Ser)

NASA Astrophysics Data System (ADS)

Mukadam, Anjum S.; Townsley, D. M.; Gänsicke, B. T.; Szkody, P.; Marsh, T. R.; Robinson, E. L.; Bildsten, L.; Aungwerojwit, A.; Schreiber, M. R.; Southworth, J.; Schwope, A.; For, B.-Q.; Tovmassian, G.; Zharikov, S. V.; Hidas, M. G.; Baliber, N.; Brown, T.; Woudt, P. A.; Warner, B.; O'Donoghue, D.; Buckley, D. A. H.; Sefako, R.; Sion, E. M.

2010-05-01

Non-radial pulsations in the primary white dwarfs of cataclysmic variables can now potentially allow us to explore the stellar interior of these accretors using stellar seismology. In this context, we conducted a multi-site campaign on the accreting pulsator SDSS J161033.64-010223.3 (V386 Ser) using seven observatories located around the world in 2007 May over a duration of 11 days. We report the best-fit periodicities here, which were also previously observed in 2004, suggesting their underlying stability. Although we did not uncover a sufficient number of independent pulsation modes for a unique seismological fit, our campaign revealed that the dominant pulsation mode at 609 s is an evenly spaced triplet. The even nature of the triplet is suggestive of rotational splitting, implying an enigmatic rotation period of about 4.8 days. There are two viable alternatives assuming the triplet is real: either the period of 4.8 days is representative of the rotation period of the entire star with implications for the angular momentum evolution of these systems, or it is perhaps an indication of differential rotation with a fast rotating exterior and slow rotation deeper in the star. Investigating the possibility that a changing period could mimic a triplet suggests that this scenario is improbable, but not impossible. Using time-series spectra acquired in 2009 May, we determine the orbital period of SDSS J161033.64-010223.3 to be 83.8 ± 2.9 minutes. Three of the observed photometric frequencies from our 2007 May campaign appear to be linear combinations of the 609 s pulsation mode with the first harmonic of the orbital period at 41.5 minutes. This is the first discovery of a linear combination between non-radial pulsation and orbital motion for a variable white dwarf.

Identifying the Young Low-mass Stars within 25 pc. I. Spectroscopic Observations

NASA Astrophysics Data System (ADS)

Shkolnik, Evgenya; Liu, Michael C.; Reid, I. Neill

2009-07-01

We have completed a high-resolution (R ≈ 60,000) optical spectroscopic survey of 185 nearby M dwarfs identified using ROSAT data to select active, young objects with fractional X-ray luminosities comparable to or greater than Pleiades members. Our targets are drawn from the NStars 20 pc census and the Moving-M sample with distances determined from parallaxes or spectrophotometric relations. We limited our sample to 25 pc from the Sun, prior to correcting for pre-main-sequence overluminosity or binarity. Nearly half of the resulting M dwarfs are not present in the Gliese catalog and have no previously published spectral types. We identified 30 spectroscopic binaries (SBs) from the sample, which have strong X-ray emission due to tidal spin-up rather than youth. This is equivalent to a 16% SB fraction, with at most a handful of undiscovered SBs. We estimate upper limits on the age of the remaining M dwarfs using spectroscopic youth indicators such as surface gravity-sensitive indices (CaH and K I). We find that for a sample of field stars with no metallicity measurements, a single CaH gravity index may not be sufficient, as higher metallicities mimic lower gravity. This is demonstrated in a subsample of metal-rich radial velocity (RV) standards, which appear to have low surface gravity as measured by the CaH index, yet show no other evidence of youth. We also use additional youth diagnostics such as lithium absorption and strong Hα emission to set more stringent age limits. Eleven M dwarfs with no Hα emission or absorption are likely old (>400 Myr) and were caught during an X-ray flare. We estimate that our final sample of the 144 youngest and nearest low-mass objects in the field is less than 300 Myr old, with 30% of them being younger than 150 Myr and four very young (lap10 Myr), representing a generally untapped and well-characterized resource of M dwarfs for intensive planet and disk searches. Based on observations collected at the W. M. Keck Observatory and

Multisite tumor sampling enhances the detection of intratumor heterogeneity at all different temporal stages of tumor evolution.

PubMed

Erramuzpe, Asier; Cortés, Jesús M; López, José I

2018-02-01

Intratumor heterogeneity (ITH) is an inherent process of tumor development that has received much attention in previous years, as it has become a major obstacle for the success of targeted therapies. ITH is also temporally unpredictable across tumor evolution, which makes its precise characterization even more problematic since detection success depends on the precise temporal snapshot at which ITH is analyzed. New and more efficient strategies for tumor sampling are needed to overcome these difficulties which currently rely entirely on the pathologist's interpretation. Recently, we showed that a new strategy, the multisite tumor sampling, works better than the routine sampling protocol for the ITH detection when the tumor time evolution was not taken into consideration. Here, we extend this work and compare the ITH detections of multisite tumor sampling and routine sampling protocols across tumor time evolution, and in particular, we provide in silico analyses of both strategies at early and late temporal stages for four different models of tumor evolution (linear, branched, neutral, and punctuated). Our results indicate that multisite tumor sampling outperforms routine protocols in detecting ITH at all different temporal stages of tumor evolution. We conclude that multisite tumor sampling is more advantageous than routine protocols in detecting intratumor heterogeneity.

Multisite Reliability of MR-Based Functional Connectivity

PubMed Central

Noble, Stephanie; Scheinost, Dustin; Finn, Emily S.; Shen, Xilin; Papademetris, Xenophon; McEwen, Sarah C.; Bearden, Carrie E.; Addington, Jean; Goodyear, Bradley; Cadenhead, Kristin S.; Mirzakhanian, Heline; Cornblatt, Barbara A.; Olvet, Doreen M.; Mathalon, Daniel H.; McGlashan, Thomas H.; Perkins, Diana O.; Belger, Aysenil; Seidman, Larry J.; Thermenos, Heidi; Tsuang, Ming T.; van Erp, Theo G.M.; Walker, Elaine F.; Hamann, Stephan; Woods, Scott W.; Cannon, Tyrone D.; Constable, R. Todd

2016-01-01

Recent years have witnessed an increasing number of multisite MRI functional connectivity (fcMRI) studies. While multisite studies are an efficient way to speed up data collection and increase sample sizes, especially for rare clinical populations, any effects of site or MRI scanner could ultimately limit power and weaken results. Little data exists on the stability of functional connectivity measurements across sites and sessions. In this study, we assess the influence of site and session on resting state functional connectivity measurements in a healthy cohort of traveling subjects (8 subjects scanned twice at each of 8 sites) scanned as part of the North American Prodrome Longitudinal Study (NAPLS). Reliability was investigated in three types of connectivity analyses: (1) seed-based connectivity with posterior cingulate cortex (PCC), right motor cortex (RMC), and left thalamus (LT) as seeds; (2) the intrinsic connectivity distribution (ICD), a voxel-wise connectivity measure; and (3) matrix connectivity, a whole-brain, atlas-based approach assessing connectivity between nodes. Contributions to variability in connectivity due to subject, site, and day-of-scan were quantified and used to assess between-session (test-retest) reliability in accordance with Generalizability Theory. Overall, no major site, scanner manufacturer, or day-of-scan effects were found for the univariate connectivity analyses; instead, subject effects dominated relative to the other measured factors. However, summaries of voxel-wise connectivity were found to be sensitive to site and scanner manufacturer effects. For all connectivity measures, although subject variance was three times the site variance, the residual represented 60–80% of the variance, indicating that connectivity differed greatly from scan to scan independent of any of the measured factors (i.e., subject, site, and day-of-scan). Thus, for a single 5 min scan, reliability across connectivity measures was poor (ICC=0.07–0

Observational artifacts of Nuclear Spectroscopic Telescope Array: ghost rays and stray light

NASA Astrophysics Data System (ADS)

Madsen, Kristin K.; Christensen, Finn E.; Craig, William W.; Forster, Karl W.; Grefenstette, Brian W.; Harrison, Fiona A.; Miyasaka, Hiromasa; Rana, Vikram

2017-10-01

The Nuclear Spectroscopic Telescope Array (NuSTAR) launched in June 2012, flies two conical approximation Wolter-I mirrors at the end of a 10.15-m mast. The optics are coated with multilayers of Pt/C and W/Si that operate from 3 to 80 keV. Since the optical path is not shrouded, aperture stops are used to limit the field of view (FoV) from background and sources outside the FoV. However, there is still a sliver of sky (˜1.0 deg to 4.0 deg) where photons may bypass the optics altogether and fall directly on the detector array. We term these photons stray light. Additionally, there are also photons that do not undergo the focused double reflections in the optics, and we term these ghost rays. We present detailed analysis and characterization of these two components and discuss how they impact observations. Finally, we discuss how they could have been prevented and should be in future observatories.

Power Calculations for Moderators in Multi-Site Cluster Randomized Trials

ERIC Educational Resources Information Center

Spybrook, Jessaca; Kelcey, Ben; Dong, Nianbo

2016-01-01

Cluster randomized trials (CRTs), or studies in which intact groups of individuals are randomly assigned to a condition, are becoming more common in evaluation studies of educational programs. A specific type of CRT in which clusters are randomly assigned to treatment within blocks or sites, known as multisite cluster randomized trials (MSCRTs),…

The value and potential of multisited ethnography for science education research: a review of Jrène Rahm's Science in the Making at the Margin

NASA Astrophysics Data System (ADS)

Beeman-Cadwallader, Nicole

2012-03-01

Rahm sought to illuminate how children and youth make meaning of science in three out-of-school time programs, and the identity work that is done through the trajectory of their youth toward their young adulthood. Through using multisited ethnography, she asserts that we can learn more about what the youth say about their science learning and science literacy development in these programs. She has revealed through her rich data the potential value of multisited ethnography for science education research. A similar theme of insider/outsider status to science emerged in each of the three sites. The nature of the data collected in Rahm's multisited ethnography allowed for the unveiling of the similarities in this theme, but also made evident the nuanced ways that this theme presented itself differently across the three sites. The additional potential came through in the varied data Rahm could have delved into and did not. A unique characteristic of ethnographic research, that is not necessarily present in other research methods, is that a wide array of varied data is collected. An analysis of documents, images, and observational field notes, which go beyond interview data, may provide deeper understandings previously untouched in science education.

Quantum simulation. Spectroscopic observation of SU(N)-symmetric interactions in Sr orbital magnetism.

PubMed

Zhang, X; Bishof, M; Bromley, S L; Kraus, C V; Safronova, M S; Zoller, P; Rey, A M; Ye, J

2014-09-19

SU(N) symmetry can emerge in a quantum system with N single-particle spin states when spin is decoupled from interparticle interactions. Taking advantage of the high measurement precision offered by an ultrastable laser, we report a spectroscopic observation of SU(N ≤ 10) symmetry in (87)Sr. By encoding the electronic orbital degree of freedom in two clock states while keeping the system open to as many as 10 nuclear spin sublevels, we probed the non-equilibrium two-orbital SU(N) magnetism via Ramsey spectroscopy of atoms confined in an array of two-dimensional optical traps; we studied the spin-orbital quantum dynamics and determined the relevant interaction parameters. This study lays the groundwork for using alkaline-earth atoms as testbeds for important orbital models. Copyright © 2014, American Association for the Advancement of Science.

A Multisite Cluster Randomized Field Trial of Open Court Reading

ERIC Educational Resources Information Center

Borman, Geoffrey D.; Dowling, N. Maritza; Schneck, Carrie

2008-01-01

In this article, the authors report achievement outcomes of a multisite cluster randomized field trial of Open Court Reading 2005 (OCR), a K-6 literacy curriculum published by SRA/McGraw-Hill. The participants are 49 first-grade through fifth-grade classrooms from predominantly minority and poor contexts across the nation. Blocking by grade level…

Network cyberinfrastructure as a shared platform to support multi-site research

USDA-ARS?s Scientific Manuscript database

Multi-site research across the Long-term Agroecosystem Research (LTAR) network requires access to data and information. We present some existing examples where you can get data from across the network and summarize the rich inventory of measurements taken across LTAR sites. But data management suppo...

A P&T Committee’s Transition to a Complete Electronic Meeting System—A Multisite Institution Experience

PubMed Central

Al-Jedai, Ahmed H.; Algain, Roaa A.; Alghamidi, Said A.; Al-Jazairi, Abdulrazaq S.; Amin, Rashid; Bin Hussain, Ibrahim Z.

2017-01-01

Purpose In the last few decades, changes to formulary management processes have taken place in institutions with closed formulary systems. However, many P&T committees continued to operate using traditional paper-based systems. Paper-based systems have many limitations, including confidentiality, efficiency, open voting, and paper wastage. This becomes more challenging when dealing with a multisite P&T committee that handles formulary matters across the whole health care system. In this paper, we discuss the implementation of the first paperless, completely electronic, Web-based formulary management system across a large health care system in the Middle East. Summary We describe the transitioning of a multisite P&T committee in a large tertiary care institution from a paper-based to an all-electronic system. The challenges and limitations of running a multisite P&T committee utilizing a paper system are discussed. The design and development of a Web-based committee floor management application that can be used from notebooks, tablets, and hand-held devices is described. Implementation of a flexible, interactive, easy-to-use, and efficient electronic formulary management system is explained in detail. Conclusion The development of an electronic P&T committee meeting system that encompasses electronic document sharing, voting, and communication could help multisite health care systems unify their formularies across multiple sites. Our experience might not be generalizable to all institutions because this depends heavily on system features, existing processes and workflow, and implementation across different sites. PMID:29018301

Reading Profiles in Multi-Site Data With Missingness.

PubMed

Eckert, Mark A; Vaden, Kenneth I; Gebregziabher, Mulugeta

2018-01-01

Children with reading disability exhibit varied deficits in reading and cognitive abilities that contribute to their reading comprehension problems. Some children exhibit primary deficits in phonological processing, while others can exhibit deficits in oral language and executive functions that affect comprehension. This behavioral heterogeneity is problematic when missing data prevent the characterization of different reading profiles, which often occurs in retrospective data sharing initiatives without coordinated data collection. Here we show that reading profiles can be reliably identified based on Random Forest classification of incomplete behavioral datasets, after the missForest method is used to multiply impute missing values. Results from simulation analyses showed that reading profiles could be accurately classified across degrees of missingness (e.g., ∼5% classification error for 30% missingness across the sample). The application of missForest to a real multi-site dataset with missingness ( n = 924) showed that reading disability profiles significantly and consistently differed in reading and cognitive abilities for cases with and without missing data. The results of validation analyses indicated that the reading profiles (cases with and without missing data) exhibited significant differences for an independent set of behavioral variables that were not used to classify reading profiles. Together, the results show how multiple imputation can be applied to the classification of cases with missing data and can increase the integrity of results from multi-site open access datasets.

Biological Stress Systems, Adverse Life Events, and the Improvement of Chronic Multisite Musculoskeletal Pain Across a 6-Year Follow-Up.

PubMed

Generaal, Ellen; Vogelzangs, Nicole; Macfarlane, Gary J; Geenen, Rinie; Smit, Johannes H; de Geus, Eco J C N; Dekker, Joost; Penninx, Brenda W J H

2017-02-01

Dysfunction of biological stress systems and adverse life events, independently and in interaction, have been hypothesized to predict chronic pain persistence. Conversely, these factors may hamper the improvement of chronic pain. Longitudinal evidence is currently lacking. We examined whether: 1) function of biological stress systems, 2) adverse life events, and 3) their combination predict the improvement of chronic multisite musculoskeletal pain. Subjects of the Netherlands Study of Depression and Anxiety (NESDA) with chronic multisite musculoskeletal pain at baseline (N = 665) were followed-up 2, 4, and 6 years later. The Chronic Pain Grade Questionnaire was used to determine improvement (not meeting the criteria) of chronic multisite musculoskeletal pain at follow-up. Baseline assessment of biological stress systems included function of hypothalamic-pituitary-adrenal axis (1-hour cortisol awakening response, evening level, and post dexamethasone level), the immune system (basal and lipopolysaccharide-stimulated inflammatory markers), the autonomic nervous system (heart rate, pre-ejection period, SD of the normal-to-normal interval, and respiratory sinus arrhythmia). The number of adverse life events were assessed at baseline and 2-year follow-up using the List of Threatening Events Questionnaire. We showed that hypothalamic-pituitary-adrenal axis, immune system, and autonomic nervous system functioning and adverse life events were not associated with the improvement of chronic multisite musculoskeletal pain, either as a main effect or in interaction. This longitudinal study could not confirm that biological stress system dysfunction and adverse life events affect the course of chronic multisite musculoskeletal pain. Biological stress systems and adverse life events are not associated with the improvement of chronic multisite musculoskeletal pain over 6 years of follow-up. Other determinants should thus be considered in future research to identify in which

Brief Treatments for Cannabis Dependence: Findings From a Randomized Multisite Trial

ERIC Educational Resources Information Center

Babor, Thomas F.

2004-01-01

This study evaluated the efficacy of 2 brief interventions for cannabis-dependent adults. A multisite randomized controlled trial compared cannabis use outcomes across 3 study conditions: (a) 2 sessions of motivational enhancement therapy (MET); (b) 9 sessions of multicomponent therapy that included MET, cognitive-behavioral therapy, and case…

Statistical Analysis for Multisite Trials Using Instrumental Variables with Random Coefficients

ERIC Educational Resources Information Center

Raudenbush, Stephen W.; Reardon, Sean F.; Nomi, Takako

2012-01-01

Multisite trials can clarify the average impact of a new program and the heterogeneity of impacts across sites. Unfortunately, in many applications, compliance with treatment assignment is imperfect. For these applications, we propose an instrumental variable (IV) model with person-specific and site-specific random coefficients. Site-specific IV…

Spectroscopic observations of V443 Herculis - A symbiotic binary with a low mass white dwarf

NASA Technical Reports Server (NTRS)

Dobrzycka, Danuta; Kenyon, Scott J.; Mikolajewska, Joanna

1993-01-01

We present an analysis of new and existing photometric and spectroscopic observations of the symbiotic binary V443 Herculis. This binary system consists of a normal M5 giant and a hot compact star. These two objects have comparable luminosities: about 1500 solar for the M5 giant and about 1000 solar for the compact star. We identify three nebular regions in this binary: a small, highly ionized volume surrounding the hot component, a modestly ionized shell close to the red giant photosphere, and a less dense region of intermediate ionization encompassing both binary components. The system parameters for V443 Her suggest the hot component currently declines from a symbiotic nova eruption.

Spectroscopic observation of SN2017gkk by NUTS (NOT Un-biased Transient Survey)

NASA Astrophysics Data System (ADS)

Onori, F.; Benetti, S.; Cappellaro, E.; Losada, Illa R.; Gafton, E.; NUTS Collaboration

2017-09-01

The Nordic Optical Telescope (NOT) Unbiased Transient Survey (NUTS; ATel #8992) reports the spectroscopic classification of supernova SN2017gkk (=MASTER OT J091344.71762842.5) in host galaxy NGC 2748.

Unlimited multistability in multisite phosphorylation systems.

PubMed

Thomson, Matthew; Gunawardena, Jeremy

2009-07-09

Reversible phosphorylation on serine, threonine and tyrosine is the most widely studied posttranslational modification of proteins. The number of phosphorylated sites on a protein (n) shows a significant increase from prokaryotes, with n /= 150 sites. Multisite phosphorylation has many roles and site conservation indicates that increasing numbers of sites cannot be due merely to promiscuous phosphorylation. A substrate with n sites has an exponential number (2(n)) of phospho-forms and individual phospho-forms may have distinct biological effects. The distribution of these phospho-forms and how this distribution is regulated have remained unknown. Here we show that, when kinase and phosphatase act in opposition on a multisite substrate, the system can exhibit distinct stable phospho-form distributions at steady state and that the maximum number of such distributions increases with n. Whereas some stable distributions are focused on a single phospho-form, others are more diffuse, giving the phospho-proteome the potential to behave as a fluid regulatory network able to encode information and flexibly respond to varying demands. Such plasticity may underlie complex information processing in eukaryotic cells and suggests a functional advantage in having many sites. Our results follow from the unusual geometry of the steady-state phospho-form concentrations, which we show to constitute a rational algebraic curve, irrespective of n. We thereby reduce the complexity of calculating steady states from simulating 3 x 2(n) differential equations to solving two algebraic equations, while treating parameters symbolically. We anticipate that these methods can be extended to systems with multiple substrates and multiple enzymes catalysing different modifications, as found in posttranslational modification 'codes' such as the histone code. Whereas simulations struggle with exponentially increasing molecular complexity

Spectroscopic observation of ASASSN-17he by NUTS (NOT Un-biased Transient Survey)

NASA Astrophysics Data System (ADS)

Kostrzewa-Rutkowska, Z.; Benetti, S.; Dong, S.; Stritzinger, M.; Stanek, K.; Brimacombe, J.; Sagues, A.; Galindo, P.; Losada, I. Rivero

2017-10-01

The Nordic Optical Telescope (NOT) Unbiased Transient Survey (NUTS; ATel #8992) reports the spectroscopic classification of ASASSN-17he. The candidate was discovered by by the All-Sky Automated Survey for Supernovae.

Testing the Feasibility of Fidelity Evaluation in a Multisite, Multiprogram Initiative

ERIC Educational Resources Information Center

Cornish, Disa Lubker; Losch, Mary E.; Avery, Mitchell

2016-01-01

Monitoring fidelity of implementation is a critical task when initiating evidence-based programs. This pilot study sought to identify best practices in a fidelity monitoring process and determine the feasibility of continuing a fidelity monitoring process with a multisite, multiprogram initiative. A fidelity log was created for each of 11…

Optical Spectroscopic Observations of γ-Ray Blazar Candidates. III. The 2013/2014 Campaign in the Southern Hemisphere

NASA Astrophysics Data System (ADS)

Landoni, M.; Massaro, F.; Paggi, A.; D'Abrusco, R.; Milisavljevic, D.; Masetti, N.; Smith, H. A.; Tosti, G.; Chomiuk, L.; Strader, J.; Cheung, C. C.

2015-05-01

We report the results of our exploratory program carried out with the southern Astrophysical Research telescope aimed at associating counterparts and establishing the nature of the Fermi Unidentified γ-ray Sources (UGSs). We selected the optical counterparts of six UGSs from the Fermi catalog on the basis of our recently discovered tight connection between infrared and γ-ray emission found for the γ-ray blazars detected by the Wide-Field Infrared Survey Explorer in its all-sky survey. We perform for the first time a spectroscopic study of the low-energy counterparts of the Fermi UGSs, in the optical band, confirming the blazar-like nature of the whole sample. We also present new spectroscopic observations of six active galaxies of uncertain type associated with Fermi sources which appear to be BL Lac objects. Finally, we report the spectra collected for six known γ-ray blazars belonging to the Roma BZCAT that were obtained to establish their nature or better estimate their redshifts. Two interesting cases of high redshift and extremely luminous BL Lac objects (z ≥ 1.18 and z ≥ 1.02, based on the detection of Mg ii intervening systems) are also discussed. Based on observations obtained at the southern Astrophysical Research (SOAR) telescope, which is a joint project of the Ministério da Ciência, Tecnologia, e Inovação (MCTI) da República Federativa do Brasil, the U.S. National Optical Astronomy Observatory (NOAO), the University of North Carolina at Chapel Hill (UNC), and Michigan State University (MSU).

Transmission Heterogeneity and Autoinoculation in a Multisite Infection Model of HPV

PubMed Central

Brouwer, Andrew F.; Meza, Rafael; Eisenberg, Marisa C.

2015-01-01

The human papillomavirus (HPV) is sexually transmitted and can infect oral, genital, and anal sites in the human epithelium. Here, we develop a multisite transmission model that includes autoinoculation, to study HPV and other multisite diseases. Under a homogeneous-contacts assumption, we analyze the basic reproduction number R0, as well as type and target reproduction numbers, for a two-site model. In particular, we find that R0 occupies a space between taking the maximum of next generation matrix terms for same site transmission and taking the geometric average of cross-site transmission terms in such a way that heterogeneity in the same-site transmission rates increases R0 while heterogeneity in the cross-site transmission decreases it. Additionally, autoinoculation adds considerable complexity to the form of R0. We extend this analysis to a heterosexual population, which additionally yields dynamics analogous to those of vector–host models. We also examine how these issues of heterogeneity may affect disease control, using type and target reproduction numbers. PMID:26518265

Patterns of disclosure among youth who are HIV-positive: a multisite study.

PubMed

Dempsey, Allison G; MacDonell, Karen E; Naar-King, Sylvie; Lau, Chuen-Yen

2012-03-01

Disclosure of serostatus is critical in preventing the transmission of HIV among youth. The purpose of this exploratory study was to describe serostatus disclosure in a multisite study of youth living with HIV. This study investigated serostatus disclosure and its relationship to unprotected sex among 146 youth participating in a multisite study of young people living with HIV who were sexually active within the past 3 months. Forty percent of participants reported a sexual relationship with a partner to whom they had not disclosed their serostatus. Participants with multiple sexual partners were less likely to disclose their serostatus than those with one partner. Disclosure was more frequent when the serostatus of the sexual partner was known. Disclosure was not associated with unprotected sex. Prevention initiatives should focus on both disclosure and condom use in this high-risk population, particularly for youth with multiple sexual partners. Copyright © 2012 Society for Adolescent Health and Medicine. All rights reserved.

MID-INFRARED SPECTROSCOPIC OBSERVATIONS OF THE DUST-FORMING CLASSICAL NOVA V2676 OPH

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kawakita, Hideyo; Arai, Akira; Shinnaka, Yoshiharu

2017-02-01

The dust-forming nova V2676 Oph is unique in that it was the first nova to provide evidence of C{sub 2} and CN molecules during its near-maximum phase and evidence of CO molecules during its early decline phase. Observations of this nova have revealed the slow evolution of its lightcurves and have also shown low isotopic ratios of carbon ({sup 12}C/{sup 13}C) and nitrogen ({sup 14}N/{sup 15}N) in its envelope. These behaviors indicate that the white dwarf (WD) star hosting V2676 Oph is a CO-rich WD rather than an ONe-rich WD (typically larger in mass than the former). We performed mid-infraredmore » spectroscopic and photometric observations of V2676 Oph in 2013 and 2014 (respectively 452 and 782 days after its discovery). No significant [Ne ii] emission at 12.8 μ m was detected at either epoch. These provided evidence for a CO-rich WD star hosting V2676 Oph. Both carbon-rich and oxygen-rich grains were detected in addition to an unidentified infrared feature at 11.4 μ m originating from polycyclic aromatic hydrocarbon molecules or hydrogenated amorphous carbon grains in the envelope of V2676 Oph.« less

Learning about and from a Distribution of Program Impacts Using Multisite Trials

ERIC Educational Resources Information Center

Raudenbush, Stephen W.; Bloom, Howard S.

2015-01-01

The present article provides a synthesis of the conceptual and statistical issues involved in using multisite randomized trials to learn about and from a distribution of heterogeneous program impacts across individuals and/or program sites. Learning "about" such a distribution involves estimating its mean value, detecting and quantifying…

A Multisite Psychotherapy and Medication Trial for Depressed Adolescents: Background and Benefits

ERIC Educational Resources Information Center

Kratochvil, Christopher J.; Simons, Anne; Vitiello, Benedetto; Walkup, John; Emslie, Graham; Rosenberg, David; March, John S.

2005-01-01

The Treatment for Adolescents With Depression Study (TADS) is an NIMH-supported multisite clinical trial that compares the effectiveness of a depression-specific cognitive behavioral therapy (CBT), medication management with fluoxetine (FLX), the combination of CBT and FLX (COMB), and medical management with pill placebo (PBO). TADS was…

Spectroscopic Diagnostics of the Non-Maxwellian κ-distributions Using SDO/EVE Observations of the 2012 March 7 X-class Flare

NASA Astrophysics Data System (ADS)

Dzifčáková, Elena; Zemanová, Alena; Dudík, Jaroslav; Mackovjak, Šimon

2018-02-01

Spectroscopic observations made by the Extreme Ultraviolet Variability Experiment (EVE) on board the Solar Dynamics Observatory (SDO) during the 2012 March 7 X5.4-class flare (SOL2012-03-07T00:07) are analyzed for signatures of the non-Maxwellian κ-distributions. Observed spectra were averaged over 1 minute to increase photon statistics in weaker lines and the pre-flare spectrum was subtracted. Synthetic line intensities for the κ-distributions are calculated using the KAPPA database. We find strong departures (κ ≲ 2) during the early and impulsive phases of the flare, with subsequent thermalization of the flare plasma during the gradual phase. If the temperatures are diagnosed from a single line ratio, the results are strongly dependent on the value of κ. For κ = 2, we find temperatures about a factor of two higher than the commonly used Maxwellian ones. The non-Maxwellian effects could also cause the temperatures diagnosed from line ratios and from the ratio of GOES X-ray channels to be different. Multithermal analysis reveals the plasma to be strongly multithermal at all times with flat DEMs. For lower κ, the {{DEM}}κ are shifted toward higher temperatures. The only parameter that is nearly independent of κ is electron density, where we find log({n}{{e}} [{{cm}}-3]) ≈ 11.5 almost independently of time. We conclude that the non-Maxwellian effects are important and should be taken into account when analyzing solar flare observations, including spectroscopic and imaging ones.

Multi-Wavelength Spectroscopic Observations of a White Light Flare Produced Directly by Non-thermal Electrons

NASA Astrophysics Data System (ADS)

Lee, Kyoung-Sun; Imada, Shinsuke; Watanabe, Kyoko; Bamba, Yumi; Brooks, David

2017-08-01

An X1.6 flare on 2014 October 22 was observed by multiple spectrometers in UV, EUV and X-ray (Hinode/EIS, IRIS, and RHESSI), and multi-wavelength imaging observations (SDO/AIA and HMI). We analyze a bright kernel that produces a white light (WL) flare with continuum enhancement and a hard X-ray (HXR) peak. Taking advantage of the spectroscopic observations of IRIS and Hinode/EIS, we measure the temporal variation of the plasma properties in the bright kernel in the chromosphere and corona. We find that explosive evaporation was observed when the WL emission occurred. The temporal correlation of the WL emission, HXR peak, and evaporation flows indicates that the WL emission was produced by accelerated electrons. We calculated the energy flux deposited by non-thermal electrons (observed by RHESSI) and compared it to the dissipated energy estimated from a chromospheric line (Mg II triplet) observed by IRIS. The deposited energy flux from the non-thermal electrons is about (3-7.7)x1010 erg cm-2 s-1 for a given low-energy cutoff of 30-40 keV, assuming the thick-target model. The energy flux estimated from the changes in temperature in the chromosphere measured using the Mg II subordinate line is about (4.6-6.7)×109 erg cm-2 s-1: ˜6%-22% of the deposited energy. This comparison of estimated energy fluxes implies that the continuum enhancement was directly produced by the non-thermal electrons.

Proton adsorption onto alumina: extension of multisite complexation (MUSIC) theory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nagashima, K.; Blum, F.D.

1999-09-01

The adsorption isotherm of protons onto a commercial {gamma}-alumina sample was determined in aqueous nitric acid with sodium nitrate as a background electrolyte. Three discrete regions could be discerned in the log-log plots of the proton isotherm determined at the solution pH 5 to 2. The multisite complexation (MUSIC) model was modified to analyze the simultaneous adsorption of protons onto various kinds of surface species.

A Multi-Site Study on Medical School Selection, Performance, Motivation and Engagement

ERIC Educational Resources Information Center

Wouters, A.; Croiset, G.; Schripsema, N. R.; Cohen-Schotanus, J.; Spaai, G. W.; Hulsman, R. L.; Kusurkar, R. A.

2017-01-01

Medical schools seek ways to improve their admissions strategies, since the available methods prove to be suboptimal for selecting the best and most motivated students. In this multi-site cross-sectional questionnaire study, we examined the value of (different) selection procedures compared to a weighted lottery procedure, which includes direct…

Multisite Interactions in Lattice-Gas Models

NASA Astrophysics Data System (ADS)

Einstein, T. L.; Sathiyanarayanan, R.

For detailed applications of lattice-gas models to surface systems, multisite interactions often play at least as significant a role as interactions between pairs of adatoms that are separated by a few lattice spacings. We recall that trio (3-adatom, non-pairwise) interactions do not inevitably create phase boundary asymmetries about half coverage. We discuss a sophisticated application to an experimental system and describe refinements in extracting lattice-gas energies from calculations of total energies of several different ordered overlayers. We describe how lateral relaxations complicate matters when there is direct interaction between the adatoms, an issue that is important when examining the angular dependence of step line tensions. We discuss the connector model as an alternative viewpoint and close with a brief account of recent work on organic molecule overlayers.

NIR Spectroscopic Observation of Massive Galaxies in the Protocluster at z = 3.09

NASA Astrophysics Data System (ADS)

Kubo, Mariko; Yamada, Toru; Ichikawa, Takashi; Kajisawa, Masaru; Matsuda, Yuichi; Tanaka, Ichi

2015-01-01

We present the results of near-infrared spectroscopic observations of the K-band-selected candidate galaxies in the protocluster at z = 3.09 in the SSA22 field. We observed 67 candidates with K AB < 24 and confirmed redshifts of the 39 galaxies at 2.0 < z spec < 3.4. Of the 67 candidates, 24 are certainly protocluster members with 3.04 <= z spec <= 3.12, which are massive red galaxies that have been unidentified in previous optical observations of the SSA22 protocluster. Many distant red galaxies (J - K AB > 1.4), hyper extremely red objects (J - K AB > 2.1), Spitzer MIPS 24 μm sources, active galactic nuclei (AGNs) as well as the counterparts of Lyα blobs and the AzTEC/ASTE 1.1 mm sources in the SSA22 field are also found to be protocluster members. The mass of the SSA22 protocluster is estimated to be ~2-5 × 1014 M ⊙, and this system is plausibly a progenitor of the most massive clusters of galaxies in the current universe. The reddest (J - K AB >= 2.4) protocluster galaxies are massive galaxies with M star ~ 1011 M ⊙ showing quiescent star formation activities and plausibly dominated by old stellar populations. Most of these massive quiescent galaxies host moderately luminous AGNs detected by X-ray. There are no significant differences in the [O III] λ5007/Hβ emission line ratios and [O III] λ5007 line widths and spatial extents of the protocluster galaxies from those of massive galaxies at z ~ 2-3 in the general field.

Perceived sleep deficit is a strong predictor of RLS in multisite pain - A population based study in middle aged females.

PubMed

Stehlik, Romana; Ulfberg, Jan; Zou, Ding; Hedner, Jan; Grote, Ludger

2017-10-01

Chronic pain conditions as well as Restless Legs Syndrome (RLS) are known to be associated with subjectively and objectively disturbed sleep. RLS has been recently described as highly prevalent in multisite pain and the role of sleep as a modifying factor in this RLS phenotype is unknown. This study aimed to investigate if perceived sleep deficit and other sleep related parameters predict RLS in subjects with multisite pain. We have recently demonstrated a strong association between Restless Legs Syndrome (RLS) and number of pain locations. In the current analysis we hypothesized that impaired sleep predicts RLS in subjects with multisite pain. Questionnaire-based data from 2727 randomly selected women aged 18-64 years were used to analyze RLS symptoms, self-reported sleep quality, and the degree of daytime sleepiness (Epworth Sleepiness Scale (ESS)) in relation to type, degree and localization of body pain. Potential confounders including anthropometrics, pain localization, co-morbidities, and medication were adjusted for in the Generalized Linear Models (GLM). Perceived sleep deficit ≥90min (OR 2.4 (1.5-3.8), p<0.001) and frequent nocturnal awakenings (OR 2.3 (1.4-3.6), p<0.001) were the strongest sleep related predictors for RLS in subjects with multisite pain. Additional factors include prolonged sleep latency (≥30min, OR 1.8 (1.1-2.8), p=0.01) and daytime symptoms like elevated daytime sleepiness (ESS score ≥9, OR 1.8 (1.2-2.7), p=0.005). Accordingly, RLS diagnosis was associated with impaired sleep quality (TST (Total Sleep Time) -8.2min, sleep latency +8.0min, and number of awakenings from sleep +0.4, p<0.01). ESS score increased with RLS diagnosis (+0.74, p<0.01) and number of pain locations (0.5, 1.7, and 1.8 for 1, 3, and 5 pain areas, p<0.001). In addition, confounders like pain severity, the history of psychiatric disease, and current smoking were associated with impaired sleep quality in this group of females. Perceived sleep deficit and sleep

CARMENES input catalogue of M dwarfs. III. Rotation and activity from high-resolution spectroscopic observations

NASA Astrophysics Data System (ADS)

Jeffers, S. V.; Schöfer, P.; Lamert, A.; Reiners, A.; Montes, D.; Caballero, J. A.; Cortés-Contreras, M.; Marvin, C. J.; Passegger, V. M.; Zechmeister, M.; Quirrenbach, A.; Alonso-Floriano, F. J.; Amado, P. J.; Bauer, F. F.; Casal, E.; Alonso, E. Diez; Herrero, E.; Morales, J. C.; Mundt, R.; Ribas, I.; Sarmiento, L. F.

2018-06-01

CARMENES is a spectrograph for radial velocity surveys of M dwarfs with the aim of detecting Earth-mass planets orbiting in the habitable zones of their host stars. To ensure an optimal use of the CARMENES guaranteed time observations, in this paper we investigate the correlation of activity and rotation for approximately 2200 M dwarfs, ranging in spectral type from M0.0 V to M9.0 V. We present new high-resolution spectroscopic observations with FEROS, CAFE, and HRS of approximately 500 M dwarfs. For each new observation, we determined its radial velocity and measured its Hα activity index and its rotation velocity. Additionally, we have multiple observations of many stars to investigate if there are any radial velocity variations due to multiplicity. The results of our survey confirm that early-M dwarfs are Hα inactive with low rotational velocities and that late-M dwarfs are Hα active with very high rotational velocities. The results of this high-resolution analysis comprise the most extensive catalogue of rotation and activity in M dwarfs currently available. Based on observations made at the Calar Alto Observatory, Spain, the European Southern Observatory, La Silla, Chile and McDonald Observatory, USA.Tables A.1-A.3 are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/614/A76

Time-resolved spectroscopic observations of an M-dwarf flare star EV Lacertae during a flare

NASA Astrophysics Data System (ADS)

Honda, Satoshi; Notsu, Yuta; Namekata, Kosuke; Notsu, Shota; Maehara, Hiroyuki; Ikuta, Kai; Nogami, Daisaku; Shibata, Kazunari

2018-05-01

We have performed five night spectroscopic observations of the Hα line of EV Lac with a medium wavelength resolution (R ˜ 10000) using the 2 m Nayuta telescope at the Nishi-Harima Astronomical Observatory. EV Lac always possesses the Hα emission line; however, its intensity was stronger on 2015 August 15 than during the other four night periods. On this night, we observed a rapid rise (˜20 min) and a subsequent slow decrease (˜1.5 hr) of the emission-line intensity of Hα, which was probably caused by a flare. We also found an asymmetrical change in the Hα line on the same night. The enhancement has been observed in the blue wing of the Hα line during each phase of this flare (from the flare start to the flare end), and absorption components were present in its red wing during the early and later phases of the flare. Such blue enhancement (blue asymmetry) of the Hα line is sometimes seen during solar flares, but only during the early phases. Even for solar flares, little is known about the origin of the blue asymmetry. Compared with solar flare models, the presented results can lead to better understanding of the dynamics of stellar flares.

Spectroscopic Classification of Two Supernovae

NASA Astrophysics Data System (ADS)

Gomez, S.; Blanchard, P.; Nicholl, M.; Berger, E.

2018-02-01

We obtained optical spectroscopic observations of 2 transients reported to the Transient Name Server by the ATLAS survey (Tonry et al. 2011, PASP, 123, 58; Tonry et al., ATel #8680) and the Pan-STARRS Survey for Transients (PSST; Huber et al., ATel #7153; http://star.pst.qub.ac.uk/ps1threepi/).

Intraclass Correlations for Three-Level Multi-Site Cluster-Randomized Trials of Science Achievement

ERIC Educational Resources Information Center

Westine, Carl D.

2015-01-01

A cluster-randomized trial (CRT) relies on random assignment of intact clusters to treatment conditions, such as classrooms or schools (Raudenbush & Bryk, 2002). One specific type of CRT, a multi-site CRT (MSCRT), is commonly employed in educational research and evaluation studies (Spybrook & Raudenbush, 2009; Spybrook, 2014; Bloom,…

Toward Better Research on--and Thinking about--Evaluation Influence, Especially in Multisite Evaluations

ERIC Educational Resources Information Center

Mark, Melvin M.

2011-01-01

Evaluation is typically carried out with the intention of making a difference in the understandings and actions of stakeholders and decision makers. The author provides a general review of the concepts of evaluation "use," evaluation "influence," and "influence pathways," with connections to multisite evaluations. The study of evaluation influence…

Ground-based Spectroscopic Observation of Jovian Surface Structures by Using the Portable Spectrometer.

NASA Astrophysics Data System (ADS)

Iwasaki, K.; Ito, H.; Tabe, I.; Hirota, S.; Suzuki, H.

2017-12-01

Stripe patterns called belts or zones with various colors persist on Jovian surface. Anticyclonic vortices called an oval with various scales and colors are maintained and drifted in the boundary between zones and belts. Some ovals have different colors despite they are formed simultaneously in the same latitude region. Color changes of ovals after an interaction with other ovals have been also reported [Sánchez-Lavega et al., JGR, 2013]. The great red spot (GRS) is one of the most remarkable structures in the Jupiter and recognized since 300 years ago by sketch and photographic observations. Recently, NASA spacecraft, JUNO has revealed more complex and fine features with various colors. A close relationship between dynamics of Jovian atmosphere and local colors is well known [Sánchez-Lavega et al., JGR, 2013] though detailed mechanisms connecting them are not fully understood. Thus, the color of the each structures is thought to be one of the keys to investigate dynamics of the Jovian atmosphere. In this study, ground-based spectroscopic observations focusing on Jovian surface structures have been conducted since December 2015. The observation is carried out by combining a telescope with a small unit for spectroscopy consists of a CCD camera and a spectrometer. The spectrometer can measure a spectrum of a selected area within an image data simultaneously obtained by the CCD camera. Dimensions and weight of the spectroscopy are only 18cm × 14cm × 4cm and 300 g, respectively. This high portability of the spectrometer enables flexible observations; we can bring the spectrometer to a public observatory which has a large telescope in a location with high clear skies rate in desired observation period. The spectra are converted and corrected to an absolute radiance at the top of atmosphere, by using a radiometric calibration data obtained with an integrating sphere and measured extinction coefficients of the local atmosphere. In this talk, temporal variations in the

Conducting a team-based multi-sited focused ethnography in primary care.

PubMed

Bikker, A P; Atherton, H; Brant, H; Porqueddu, T; Campbell, J L; Gibson, A; McKinstry, B; Salisbury, C; Ziebland, S

2017-09-12

Focused ethnography is an applied and pragmatic form of ethnography that explores a specific social phenomenon as it occurs in everyday life. Based on the literature a problem-focused research question is formulated before the data collection. The data generation process targets key informants and situations so that relevant results on the pre-defined topic can be obtained within a relatively short time-span. As part of a theory based evaluation of alternative forms of consultation (such as video, phone and email) in primary care we used the focused ethnographic method in a multisite study in general practice across the UK. To date there is a gap in the literature on using focused ethnography in healthcare research.The aim of the paper is to build on the various methodological approaches in health services research by presenting the challenges and benefits we encountered whilst conducing a focused ethnography in British primary care. Our considerations are clustered under three headings: constructing a shared understanding, dividing the tasks within the team, and the functioning of the focused ethnographers within the broader multi-disciplinary team.As a result of using this approach we experienced several advantages, like the ability to collect focused data in several settings simultaneously within in a short time-span. Also, the sharing of experiences and interpretations between the researchers contributed to a more holistic understanding of the research topic. However, mechanisms need to be in place to facilitate and synthesise the observations, guide the analysis, and to ensure that all researchers feel engaged. Reflection, trust and flexibility among the team members were crucial to successfully adopt a team focused ethnographic approach. When used for policy focussed applied healthcare research a team-based multi-sited focused ethnography can uncover practices and understandings that would not be apparent through surveys or interviews alone. If conducted with

SPECTROSCOPIC ORBITS FOR 15 LATE-TYPE STARS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Willmarth, Daryl W.; Abt, Helmut A.; Fekel, Francis C.

2016-08-01

Spectroscopic orbital elements are determined for 15 stars with periods from 8 to 6528 days with six orbits computed for the first time. Improved astrometric orbits are computed for two stars and one new orbit is derived. Visual orbits were previously determined for four stars, four stars are members of multiple systems, and five stars have Hipparcos “G” designations or have been resolved by speckle interferometry. For the nine binaries with previous spectroscopic orbits, we determine improved or comparable elements. For HD 28271 and HD 200790, our spectroscopic results support the conclusions of previous authors that the large values of their massmore » functions and lack of detectable secondary spectrum argue for the secondary in each case being a pair of low-mass dwarfs. The orbits given here may be useful in combination with future interferometric and Gaia satellite observations.« less

Spectroscopic Classifications of Optical Transients with Mayall/KOSMOS

NASA Astrophysics Data System (ADS)

Pan, Y.-C.; Miller, J.; Foley, R. J.; Jha, S. W.; Rest, A.; Scolnic, D.

2016-04-01

We report the following classifications of optical transients from spectroscopic observations with the KOSMOS on the Mayall telescope. Targets were supplied by the Pan-STARRS Survey for Transients (PSST).

Spectroscopic Classifications of Optical Transients with Mayall/KOSMOS

NASA Astrophysics Data System (ADS)

Pan, Y.-C.; Narayan, G.; Foley, R. J.; Jha, S. W.; Rest, A.; Scolnic, D.; Smith, K. W.; Wright, D.; Smartt, S. J.; Huber, M.; Chambers, K. C.; Flewelling, H.; Willman, M.; Primak, N.; Schultz, A.; Gibson, B.; Magnier, E.; Waters, C.; Tonry, J.; Wainscoat, R. J.

2015-04-01

We report the following classifications of optical transients from spectroscopic observations with the KOSMOS on the Mayall telescope. Targets were supplied by the Pan-STARRS Survey for Transients (PSST).

Alteration of fluorescent protein spectroscopic properties upon cryoprotection.

PubMed

von Stetten, David; Batot, Gaëlle O; Noirclerc-Savoye, Marjolaine; Royant, Antoine

2012-11-01

Cryoprotection of a protein crystal by addition of small-molecule compounds may sometimes affect the structure of its active site. The spectroscopic and structural effects of the two cryoprotectants glycerol and ethylene glycol on the cyan fluorescent protein Cerulean were investigated. While glycerol had almost no noticeable effect, ethylene glycol was shown to induce a systematic red shift of the UV-vis absorption and fluorescence emission spectra. Additionally, ethylene glycol molecules were shown to enter the core of the protein, with one of them binding in close vicinity to the chromophore, which provides a sound explanation for the observed spectroscopic changes. These results highlight the need to systematically record spectroscopic data on crystals of light-absorbing proteins and reinforce the notion that fluorescent proteins must not been seen as rigid structures.

Spectroscopic Classification of PS16ccj with Mayall/KOSMOS

NASA Astrophysics Data System (ADS)

Pan, Y.-C.; Foley, R. J.; Jha, S. W.; Rest, A.; Scolnic, D.

2016-05-01

We report the classification of PS16ccj from spectroscopic observation with KOSMOS on the Mayall telescope. The observation was made on 2016 May 05 UT. We classify PS16ccj as a SN Ia near maximum light.

Spectroscopic Classifications of Optical Transients with Mayall/KOSMOS

NASA Astrophysics Data System (ADS)

Kilpatrick, C. D.; Siebert, M. R.; Foley, R. J.; Pan, Y.-C.; Jha, S. W.; Rest, A.; Scolnic, D.

2016-08-01

We report the following classifications of optical transients from spectroscopic observations with KOSMOS on the KPNO Mayall 4-m telescope. Targets were supplied by Shunsuke Nagata, POSS, and ASAS-SN.

Microwave spectroscopic observation of multiple phase transitions in the bilayer electron solid in wide quantum wells

NASA Astrophysics Data System (ADS)

Hatke, Anthony; Engel, Lloyd; Liu, Yang; Shayegan, Mansour; Pfeiffer, Loren; West, Ken; Baldwin, Kirk

2015-03-01

The termination of the low Landau filling factor (ν) fractional quantum Hall series for a single layer two dimensional system results in the formation of a pinned Wigner solid for ν < 1 / 5. In a wide quantum well the system can support a bilayer state in which interlayer and intralayer interactions become comparable, which is measured in traditional transport as an insulating state for ν < 1 / 2. We perform microwave spectroscopic studies of this bilayer state and observe that this insulator exhibits a resonance, a signature of a solid phase. Additionally, we find that as we increase the density of the well at fixed ν this bilayer solid exhibits multiple sharp reductions in the resonance amplitude vs ν. This behavior is characteristic of multiple phase transitions, which remain hidden from dc transport measurements.

The "Cool Algol" BD+05 706 : Photometric observations of a new eclipsing double-lined spectroscopic binary

NASA Astrophysics Data System (ADS)

Marschall, L. A.; Torres, G.; Neuhauser, R.

1998-05-01

BVRI Observations of the star BD+05 706, carried out between January, 1997, and April 1998 using the 0.4m reflector and Photometrics CCD camera at the Gettysburg College Observatory, show that the star is an eclipsing binary system with a light curve characteristic of a class of semi-detached binaries known as the "cool Algols". These results are in good agreement with the previous report of BD+05 706 as a cool Algol by Torres, Neuhauser, and Wichmann,(Astron. J., 115, May 1998) who based their classification on the strong X-ray emission detected by Rosat and on a series of spectroscopic observations of the radial velocities of both components of the system obtained at the Oak Ridge Observatory, the Fred L. Whipple Observatory, and the Multiple Mirror Telescope. Only 10 other examples of cool Algols are known, and the current photometric light curve, together with the radial velocity curves obtained previously, allows us to derive a complete solution for the physical parameters of each component, providing important constraints on models for these interesting systems.

Visible Spectroscopic Observation Of Asteroid 162173 (1999ju3) With The Gemini-s Telescope

NASA Astrophysics Data System (ADS)

Sugita, Seiji; Kuroda, D.; Kameda, S.; Hasegawa, S.; Kamata, S.; Abe, M.; Ishiguro, M.; Takato, N.; Yoshikawa, M.

2012-10-01

Asteroid 162173 (1999JU3; hereafter JU3) is the target of the Hayabusa-2 mission. Its visible reflectance spectra have been observed a few times [1,2], and obtained spectra exhibit a wide variety of spectral patterns ranging from a spectra with absorption in the UV region (May 1999) to a flat spectrum with a faint broad absorption centered around 0.6 microns (September 2007) and that with UV absorption and strong broad absorption centered around 0.7 micron (July 2007). The apparent large spectral variation may be due to variegation on the asteroid surface. Such variegation would make a large influence on remote sensing strategy for Hayabusa-2 before its sampling operations. In order to better constraint the spectral properties of JU3, we conducted visible spectroscopic observations at the GEMINI-South observatory 8.1-m telescope with the GMOS instrument. We could obtain three different sets of data in June and July 2012. Although the JU3 rotation phases of two of the observation are close to each other, the other is about 120 degrees away from the two. Our preliminary analyses indicate that these three spectra are slightly reddish but generally flat across the observed wavelength range (0.47 - 0.89 microns). The observed flat spectra are most similar to the spectrum obtained in September 2007, which probably has the highest signal-to-noise ratio among the previous three spectra. This result suggests that material with a flat spectrum probably covers a dominant proportion of the JU3 surface and that the other two types of previously obtained spectra may not cover a very large fraction of the JU3 surface. [1] Binzel, R. P. et al. (2001) Icarus, 151, 139-149; [2] Vilas, F. (2008) AJ, 135, 1101-1105.

Positive Family Intervention for Severe Challenging Behavior I: A Multisite Randomized Clinical Trial

ERIC Educational Resources Information Center

Durand, V. Mark; Hieneman, Meme; Clarke, Shelley; Wang, Mo; Rinaldi, Melissa L.

2013-01-01

The present study was a multisite randomized clinical trial assessing the effects of adding a cognitive-behavioral intervention to positive behavior support (PBS). Fifty-four families who met the criteria of (a) having a child with a developmental disability, (b) whose child displayed serious challenging behavior (e.g., aggression, self-injury,…

A Qualitative Multi-Site Case Study: Examining Principals' Leadership Styles and School Performance

ERIC Educational Resources Information Center

Preyear, Loukisha

2015-01-01

The purpose of this qualitative multi-site case study was to explore the impact of principals' leadership styles on student academic achievement in a high-poverty low-performing school district in Louisiana. A total of 17 participants, principals and teachers, from this school district were used in this study. Data source triangulation of…

Variability of acute extracellular action potential measurements with multisite silicon probes

PubMed Central

Scott, Kimberly M.; Du, Jiangang; Lester, Henry A.; Masmanidis, Sotiris C.

2012-01-01

Device miniaturization technologies have led to significant advances in sensors for extracellular measurements of electrical activity in the brain. Multisite, silicon-based probes containing implantable electrode arrays afford greater coverage of neuronal activity than single electrodes and therefore potentially offer a more complete view of how neuronal ensembles encode information. However, scaling up the number of sites is not sufficient to ensure capture of multiple neurons, as action potential signals from extracellular electrodes may vary due to numerous factors. In order to understand the large-scale recording capabilities and potential limitations of multisite probes, it is important to quantify this variability, and to determine whether certain key device parameters influence the recordings. Here we investigate the effect of four parameters, namely, electrode surface, width of the structural support shafts, shaft number, and position of the recording site relative to the shaft tip. This study employs acutely implanted silicon probes containing up to 64 recording sites, whose performance is evaluated by the metrics of noise, spike amplitude, and spike detection probability. On average, we find no significant effect of device geometry on spike amplitude and detection probability but we find significant differences among individual experiments, with the likelihood of detecting spikes varying by a factor of approximately three across trials. PMID:22971352

Calibration method for spectroscopic systems

DOEpatents

Sandison, David R.

1998-01-01

Calibration spots of optically-characterized material placed in the field of view of a spectroscopic system allow calibration of the spectroscopic system. Response from the calibration spots is measured and used to calibrate for varying spectroscopic system operating parameters. The accurate calibration achieved allows quantitative spectroscopic analysis of responses taken at different times, different excitation conditions, and of different targets.

Calibration method for spectroscopic systems

DOEpatents

Sandison, D.R.

1998-11-17

Calibration spots of optically-characterized material placed in the field of view of a spectroscopic system allow calibration of the spectroscopic system. Response from the calibration spots is measured and used to calibrate for varying spectroscopic system operating parameters. The accurate calibration achieved allows quantitative spectroscopic analysis of responses taken at different times, different excitation conditions, and of different targets. 3 figs.

Applying the Brakes to Multi-Site SR Protein Phosphorylation: Substrate-Induced Effects on the Splicing Kinase SRPK1†

PubMed Central

Aubol, Brandon E.; Adams, Joseph A.

2011-01-01

To investigate how a protein kinase interacts with its protein substrate during extended, multi-site phosphorylation, the kinetic mechanism of a protein kinase involved in mRNA splicing control was investigated using rapid quench flow techniques. The protein kinase SRPK1 phosphorylates approximately 10 serines in the arginine-serine-rich domain (RS domain) of the SR protein SRSF1 in a C-to-N-terminal direction, a modification that directs this essential splicing factor from the cytoplasm to the nucleus. Transient-state kinetic experiments illustrate that the first phosphate is added rapidly onto the RS domain of SRSF1 (t1/2 = 0.1 sec) followed by slower, multi-site phosphorylation at the remaining serines (t1/2 = 15 sec). Mutagenesis experiments suggest that efficient phosphorylation rates are maintained by an extensive hydrogen bonding and electrostatic network between the RS domain of the SR protein and the active site and docking groove of the kinase. Catalytic trapping and viscosometric experiments demonstrate that while the phosphoryl transfer step is fast, ADP release limits multi-site phosphorylation. By studying phosphate incorporation into selectively pre-phosphorylated forms of the enzyme-substrate complex, the kinetic mechanism for site-specific phosphorylation along the reaction coordinate was assessed. The binding affinity of the SR protein, the phosphoryl transfer rate and ADP exchange rate were found to decline significantly as a function of progressive phosphorylation in the RS domain. These findings indicate that the protein substrate actively modulates initiation, extension and termination events associated with prolonged, multi-site phosphorylation. PMID:21728354

Insomnia, Sleep Duration, Depressive Symptoms, and the Onset of Chronic Multisite Musculoskeletal Pain.

PubMed

Generaal, Ellen; Vogelzangs, Nicole; Penninx, Brenda W J H; Dekker, Joost

2017-01-01

The temporal relationships among sleep, depressive symptoms, and pain are unclear. This longitudinal study examines whether insomnia and sleep duration predict the onset of chronic multisite musculoskeletal pain over 6 years and whether this association is mediated by depressive symptoms. 1860 subjects of the Netherlands Study of Depression and Anxiety, free from chronic multisite musculoskeletal pain at baseline, were followed up for the onset of chronic multisite musculoskeletal pain over 6 years (Chronic Pain Grade Questionnaire). We determined baseline insomnia (Women's Health Initiative Insomnia Rating Scale ≥9) and sleep duration (short: ≤6 hr, normal: 7-9 hr, long: ≥10 hr). Depressive symptoms were assessed at baseline and as a change score over time (Inventory of Depressive Symptomatology). Insomnia (hazard ratio [HR] [95% confidence interval, 95%CI] = 1.60 [1.30-1.96], p < .001) and short sleep duration (HR [95%CI] = 1.52 [1.22-1.90], p < .001) were associated with chronic pain onset. Adding baseline depressive symptoms as a mediator attenuated the associations for insomnia and short sleep with chronic pain onset (∆B = 40% and 26%, respectively). Adding the change score of depressive symptoms further weakened the association for insomnia (∆B = 16%) but not for short sleep. All direct effects for sleep measures with chronic pain onset remained statistically significant (p < .05). This longitudinal study shows that insomnia and short sleep duration are risk factors for developing chronic pain. Depressive symptoms partially mediate the effect for insomnia and short sleep with developing chronic pain. © Sleep Research Society 2016. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.

Spectroscopic Classifications of Optical Transients with Mayall/KOSMOS

NASA Astrophysics Data System (ADS)

Coulter, D. A.; Pan, Y.-C.; Kilpatrick, C. D.; Foley, R. J.

2017-06-01

We report the following classifications of optical transients from spectroscopic observations with KOSMOS on the KPNO Mayall 4-m telescope. Targets were supplied by the Pan-STARRS Survey for Transients (PSST) and Gaia.

Spectroscopic observations of X-ray selected late type stars

NASA Technical Reports Server (NTRS)

Takalo, L. O.

1988-01-01

A spectroscopic survey of nine X-ray selected late type stars was conducted. These stars are serendipitously discovered EINSTEIN X-ray sources, selected from two large x-ray surveys: the Columbia Astrophysical Laboratory survey (five stars) and the CFA Medium Sensitivity survey (four stars). Four of the Columbia survey stars were found to be short period binaries. The fifth was found to be an active single G dwarf. None of the Medium Sensitivity survey stars were found to be either binaries or active stars. Activity was measured by comparing the H-alpha and the CaII infrared triplet (8498, 8542) lines in these stars to the lines in inactive stars of similar spectral type. A correlation was found between the excess H-alpha lime emission and V sin(i) and between the excess H-alpha line emission and X-ray luminosity. No correlation was found between the infrared line emission and any other measured quantity.

Ultrasensitivity and sharp threshold theorems for multisite systems

NASA Astrophysics Data System (ADS)

Dougoud, M.; Mazza, C.; Vinckenbosch, L.

2017-02-01

This work studies the ultrasensitivity of multisite binding processes where ligand molecules can bind to several binding sites. It considers more particularly recent models involving complex chemical reactions in allosteric phosphorylation processes and for transcription factors and nucleosomes competing for binding on DNA. New statistics-based formulas for the Hill coefficient and the effective Hill coefficient are provided and necessary conditions for a system to be ultrasensitive are exhibited. It is first shown that the ultrasensitivity of binding processes can be approached using sharp-threshold theorems which have been developed in applied probability theory and statistical mechanics for studying sharp threshold phenomena in reliability theory, random graph theory and percolation theory. Special classes of binding process are then introduced and are described as density dependent birth and death process. New precise large deviation results for the steady state distribution of the process are obtained, which permits to show that switch-like ultrasensitive responses are strongly related to the multi-modality of the steady state distribution. Ultrasensitivity occurs if and only if the entropy of the dynamical system has more than one global minimum for some critical ligand concentration. In this case, the Hill coefficient is proportional to the number of binding sites, and the system is highly ultrasensitive. The classical effective Hill coefficient I is extended to a new cooperativity index I q , for which we recommend the computation of a broad range of values of q instead of just the standard one I  =  I 0.9 corresponding to the 10%-90% variation in the dose-response. It is shown that this single choice can sometimes mislead the conclusion by not detecting ultrasensitivity. This new approach allows a better understanding of multisite ultrasensitive systems and provides new tools for the design of such systems.

Site Matters: Multisite Randomized Trial of Motivational Enhancement Therapy in Community Drug Abuse Clinics

ERIC Educational Resources Information Center

Ball, Samuel A.; Martino, Steve; Nich, Charla; Frankforter, Tami L.; Van Horn, Deborah; Crits-Christoph, Paul; Woody, George E.; Obert, Jeanne L.; Farentinos, Christiane; Carroll, Kathleen M.

2007-01-01

The effectiveness of motivational enhancement therapy (MET) in comparison with counseling as usual (CAU) for increasing retention and reducing substance use was evaluated in a multisite randomized clinical trial. Participants were 461 outpatients treated by 31 therapists within 1 of 5 outpatient substance abuse programs. There were no retention…

Multisite EPR oximetry from multiple quadrature harmonics.

PubMed

Ahmad, R; Som, S; Johnson, D H; Zweier, J L; Kuppusamy, P; Potter, L C

2012-01-01

Multisite continuous wave (CW) electron paramagnetic resonance (EPR) oximetry using multiple quadrature field modulation harmonics is presented. First, a recently developed digital receiver is used to extract multiple harmonics of field modulated projection data. Second, a forward model is presented that relates the projection data to unknown parameters, including linewidth at each site. Third, a maximum likelihood estimator of unknown parameters is reported using an iterative algorithm capable of jointly processing multiple quadrature harmonics. The data modeling and processing are applicable for parametric lineshapes under nonsaturating conditions. Joint processing of multiple harmonics leads to 2-3-fold acceleration of EPR data acquisition. For demonstration in two spatial dimensions, both simulations and phantom studies on an L-band system are reported. Copyright © 2011 Elsevier Inc. All rights reserved.

[In situ Raman spectroscopic observation of micro-processes of methane hydrate formation and dissociation].

PubMed

Liu, Chang-Ling; Ye, Yu-Guang; Meng, Qing-Guo; Lü, Wan-Jun; Wang, Fei-Fei

2011-06-01

Micro laser Raman spectroscopic technique was used for in situ observation of the micro-processes of methane hydrate formed and decomposed in a high pressure transparent capillary. The changes in clathrate structure of methane hydrate were investigated during these processes. The results show that, during hydrate formation, the Raman peak (2 917 cm(-1)) of methane gas gradually splits into two peaks (2 905 and 2 915 cm(-1)) representing large and small cages, respectively, suggesting that the dissolved methane molecules go into two different chemical environments. In the meantime, the hydrogen bonds interaction is strengthened because water is changing from liquid to solid state gradually. As a result, the O-H stretching vibrations of water shift to lower wavenumber. During the decomposition process of methane hydrates, the Raman peaks of the methane molecules both in the large and small cages gradually clear up, and finally turn into a single peak of methane gas. The experimental results show that laser Raman spectroscopy can accurately demonstrate some relevant information of hydrate crystal structure changes during the formation and dissociation processes of methane hydrate.

NIR SPECTROSCOPIC OBSERVATION OF MASSIVE GALAXIES IN THE PROTOCLUSTER AT z = 3.09

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kubo, Mariko; Yamada, Toru; Ichikawa, Takashi

2015-01-20

We present the results of near-infrared spectroscopic observations of the K-band-selected candidate galaxies in the protocluster at z = 3.09 in the SSA22 field. We observed 67 candidates with K {sub AB} < 24 and confirmed redshifts of the 39 galaxies at 2.0 < z {sub spec} < 3.4. Of the 67 candidates, 24 are certainly protocluster members with 3.04 ≤ z {sub spec} ≤ 3.12, which are massive red galaxies that have been unidentified in previous optical observations of the SSA22 protocluster. Many distant red galaxies (J – K {sub AB} > 1.4), hyper extremely red objects (J –more » K {sub AB} > 2.1), Spitzer MIPS 24 μm sources, active galactic nuclei (AGNs) as well as the counterparts of Lyα blobs and the AzTEC/ASTE 1.1 mm sources in the SSA22 field are also found to be protocluster members. The mass of the SSA22 protocluster is estimated to be ∼2-5 × 10{sup 14} M {sub ☉}, and this system is plausibly a progenitor of the most massive clusters of galaxies in the current universe. The reddest (J – K {sub AB} ≥ 2.4) protocluster galaxies are massive galaxies with M {sub star} ∼ 10{sup 11} M {sub ☉} showing quiescent star formation activities and plausibly dominated by old stellar populations. Most of these massive quiescent galaxies host moderately luminous AGNs detected by X-ray. There are no significant differences in the [O III] λ5007/Hβ emission line ratios and [O III] λ5007 line widths and spatial extents of the protocluster galaxies from those of massive galaxies at z ∼ 2-3 in the general field.« less

Spectroscopic Observations of the Star Formation Regions in Nearby Galaxies

NASA Astrophysics Data System (ADS)

Kong, X.; Lin, L.; Li, J. R.; Zhou, X.; Zou, H.; Li, H. Y.; Chen, F. Z.; Du, W.; Fan, Z.; Mao, Y. W.; Wang, J.; Zhu, Y. N.; Zhou, Z. M.

2014-01-01

During the late 1990s and the first decade of the 21st century, the 8˜10 m scale ground-based telescopes are helping astronomers learn much more about how galaxies develop. The existing 2˜4 m scale telescopes become less important for astrophysical researches. To use the existing 2˜4 m scale telescopes to address important issues in cosmology and extragalactic and galactic astronomy, we have to consider very carefully which kind of things we can do, and which we can not. For this reason, the Time Allocation Committee (TAC) of the National Astronomical Observatories of China (NAOC) 2.16 m telescope decides to support some key projects since 2013. Nearby galaxies supply us with the opportunity to study galaxy dynamics and star formation on large scales, yet are close enough to reveal the details. Star formation regions in nearby galaxies provide an excellent laboratory to study the star formation processes, the evolution of massive stars, and the properties of the surrounding interstellar medium. A wealth of information can be obtained from the spectral analysis of the bright emission lines and the stellar continuum. Considering these, we proposed a long-term project ``Spectroscopic Observations of the Star Formation Regions in Nearby Galaxies'', and it becomes the key project of the NAOC 2.16 m telescope since 2013, supported with 30 dark/grey nights per year. The primary goal of this project is to observe the spectroscopy of star formation regions in 20 nearby galaxies, with the NAOC 2.16 m telescope and the Hectospec/MMT (Multiple Mirror Telescope) multifiber spectrograph by Telescope Access Program (TAP). With the spectra of a large sample of star formation regions, combining multi-wavelength data from UV to IR, we can investigate, understand, and quantify the nature of the deviation from the starbursts' IRX-β (the IR/UV ratio ``IRX'' versus the UV color ``β'') correlation. It will be important for a better understanding of the interaction of dust and

eGEMs: Pathways to Success for Multisite Clinical Data Research

PubMed Central

McGraw JD, Deven C.; Leiter JD, Alice B.

2013-01-01

There are numerous and significant challenges associated with leveraging electronic clinical data (ECD) for purposes beyond treating an individual patient and getting paid for that care. Optimizing this secondary use of clinical data is a key underpinning of many health reform goals and triggers numerous issues related to data stewardship and, more broadly, data governance. These challenges often involve legal, policy, and procedural issues related to the access, use, and disclosure of electronic health record (EHR) data for quality improvement and research. This paper contributes to the ongoing discussion of health data governance by detailing the experiences of nine multisite research initiatives across the country. The rich set of experiences from these initiatives, as well as a number of resources used by project participants to work through various challenges, are documented and collected here for others wishing to learn from their collective efforts. The paper does not attempt to catalog the full spectrum of governance issues that could potentially surface in the course of multisite research projects using ECD. Rather, the goal was to provide a snapshot in time of data-sharing challenges and navigation strategies, as well as validation that privacy-protective, legally compliant clinical data sharing across sites is currently possible. Finally, the paper also provides a foundation and framing for a broader community resource on governance—a “governance toolkit”—that will create a virtual space for the further discussion and sharing of promising practices. PMID:25848568

Multisite Reliability of Cognitive BOLD Data

PubMed Central

Brown, Gregory G.; Mathalon, Daniel H.; Stern, Hal; Ford, Judith; Mueller, Bryon; Greve, Douglas N.; McCarthy, Gregory; Voyvodic, Jim; Glover, Gary; Diaz, Michele; Yetter, Elizabeth; Burak Ozyurt, I.; Jorgensen, Kasper W.; Wible, Cynthia G.; Turner, Jessica A.; Thompson, Wesley K.; Potkin, Steven G.

2010-01-01

Investigators perform multi-site functional magnetic resonance imaging studies to increase statistical power, to enhance generalizability, and to improve the likelihood of sampling relevant subgroups. Yet undesired site variation in imaging methods could off-set these potential advantages. We used variance components analysis to investigate sources of variation in the blood oxygen level dependent (BOLD) signal across four 3T magnets in voxelwise and region of interest (ROI) analyses. Eighteen participants traveled to four magnet sites to complete eight runs of a working memory task involving emotional or neutral distraction. Person variance was more than 10 times larger than site variance for five of six ROIs studied. Person-by-site interactions, however, contributed sizable unwanted variance to the total. Averaging over runs increased between-site reliability, with many voxels showing good to excellent between-site reliability when eight runs were averaged and regions of interest showing fair to good reliability. Between-site reliability depended on the specific functional contrast analyzed in addition to the number of runs averaged. Although median effect size was correlated with between-site reliability, dissociations were observed for many voxels. Brain regions where the pooled effect size was large but between-site reliability was poor were associated with reduced individual differences. Brain regions where the pooled effect size was small but between-site reliability was excellent were associated with a balance of participants who displayed consistently positive or consistently negative BOLD responses. Although between-site reliability of BOLD data can be good to excellent, acquiring highly reliable data requires robust activation paradigms, ongoing quality assurance, and careful experimental control. PMID:20932915

New Spectroscopic Solution of the Eclipsing Binary HX Vel A

NASA Astrophysics Data System (ADS)

Sürgit, D.; Erdem, A.; Özkardeş, B.; Butland, R.; Budding, E.

2015-07-01

We present a preliminary analysis of new spectroscopic observations of the southern binary HX Vel A. High-resolution spectroscopic observations were made at the Mt. John University Observatory in 2014. Radial velocities for HX Vel A were determined from the Gaussian profile-fitting method. The Keplerian radial velocity model gives the close binary mass ratio as 0.57±0.06. The resulting orbital elements are a1sin i=0.0086 ±0.0003 au, a2sin i=0.0151 ±0.0003 au, M1 sin3i =0.887 ±0.046 M⊙, and M2 sin3i =0.504 ±0.032 M⊙.

Childhood Traumatic Grief: A Multi-Site Empirical Examination of the Construct and Its Correlates

ERIC Educational Resources Information Center

Brown, Elissa J.; Amaya-Jackson, Lisa; Cohen, Judith; Handel, Stephanie; De Bocanegra, Heike Thiel; Zatta, Eileen; Goodman, Robin F.; Mannarino, Anthony

2008-01-01

This study evaluated the construct of childhood traumatic grief (CTG) and its correlates through a multi-site assessment of 132 bereaved children and adolescents. Youth completed a new measure of the characteristics, attributions, and reactions to exposure to death (CARED), as well as measures of CTG, posttraumatic stress disorder (PTSD),…

13C-METHYL Formate in Orion-Kl Alma Observations and Spectroscopic Characterization

NASA Astrophysics Data System (ADS)

Favre, Cécile; Carvajal, Miguel; Field, David; Bergin, Edwin; Neill, Justin; Crockett, Nathan; Jørgensen, Jes; Bisschop, Suzanne; Brouillet, Nathalie; Despois, Didier; Baudry, Alain; Kleiner, Isabelle; Margulès, L.; Huet, T. R.; Demaison, Jean

2014-06-01

Determination of elemental isotopic ratios is valuable for understanding the chemical evolution of interstellar material. Until now the 12C/13C ratio has predominantly been measured in simple species such as CO, CN and H2CO and, becomes larger with increasing distance from the Galactic Center. We have investigated the carbon isotopic ratio for methyl formate HCOOCH3, and its isotopologues H13COOCH3 and HCOO13CH3 addressing the issue whether the 12C/13C ratio is the same for both simple and large molecules. Using ALMA science verification observations of Orion-KL and the spectroscopic characterization of the complex H13COOCH3 and HCOO13CH3 species that we have performed, we have 1) confirmed the detection of the 13C-methyl formate species in Orion-KL and, 2) image for the first time their spatial distribution. I will present some of these results. In particular, our analysis shows that the 12C/13C isotope ratio in methyl formate toward the Compact Ridge and Hot Core-SW components that are associated with Orion-KL are, for both the 13C-methyl formate isotopologues, commensurate with the well-known 12C/13C ratio of the simple species CO. Our findings suggest that grain surface chemistry very likely prevails in the formation of methyl formate main and 13C isotopologues.

Streamflow prediction using multi-site rainfall obtained from hydroclimatic teleconnection

NASA Astrophysics Data System (ADS)

Kashid, S. S.; Ghosh, Subimal; Maity, Rajib

2010-12-01

SummarySimultaneous variations in weather and climate over widely separated regions are commonly known as "hydroclimatic teleconnections". Rainfall and runoff patterns, over continents, are found to be significantly teleconnected, with large-scale circulation patterns, through such hydroclimatic teleconnections. Though such teleconnections exist in nature, it is very difficult to model them, due to their inherent complexity. Statistical techniques and Artificial Intelligence (AI) tools gain popularity in modeling hydroclimatic teleconnection, based on their ability, in capturing the complicated relationship between the predictors (e.g. sea surface temperatures) and predictand (e.g., rainfall). Genetic Programming is such an AI tool, which is capable of capturing nonlinear relationship, between predictor and predictand, due to its flexible functional structure. In the present study, gridded multi-site weekly rainfall is predicted from El Niño Southern Oscillation (ENSO) indices, Equatorial Indian Ocean Oscillation (EQUINOO) indices, Outgoing Longwave Radiation (OLR) and lag rainfall at grid points, over the catchment, using Genetic Programming. The predicted rainfall is further used in a Genetic Programming model to predict streamflows. The model is applied for weekly forecasting of streamflow in Mahanadi River, India, and satisfactory performance is observed.

A general Bayesian framework for calibrating and evaluating stochastic models of annual multi-site hydrological data

NASA Astrophysics Data System (ADS)

Frost, Andrew J.; Thyer, Mark A.; Srikanthan, R.; Kuczera, George

2007-07-01

SummaryMulti-site simulation of hydrological data are required for drought risk assessment of large multi-reservoir water supply systems. In this paper, a general Bayesian framework is presented for the calibration and evaluation of multi-site hydrological data at annual timescales. Models included within this framework are the hidden Markov model (HMM) and the widely used lag-1 autoregressive (AR(1)) model. These models are extended by the inclusion of a Box-Cox transformation and a spatial correlation function in a multi-site setting. Parameter uncertainty is evaluated using Markov chain Monte Carlo techniques. Models are evaluated by their ability to reproduce a range of important extreme statistics and compared using Bayesian model selection techniques which evaluate model probabilities. The case study, using multi-site annual rainfall data situated within catchments which contribute to Sydney's main water supply, provided the following results: Firstly, in terms of model probabilities and diagnostics, the inclusion of the Box-Cox transformation was preferred. Secondly the AR(1) and HMM performed similarly, while some other proposed AR(1)/HMM models with regionally pooled parameters had greater posterior probability than these two models. The practical significance of parameter and model uncertainty was illustrated using a case study involving drought security analysis for urban water supply. It was shown that ignoring parameter uncertainty resulted in a significant overestimate of reservoir yield and an underestimation of system vulnerability to severe drought.

Thermal treatment effects imposed on solid DNA cationic lipid complex with hexadecyltrimethylammonium chloride, observed by variable angle spectroscopic ellipsometry

NASA Astrophysics Data System (ADS)

Nizioł, Jacek

2014-12-01

DNA cationic lipid complexes are materials of properties required for applications in organic electronics and optoelectronics. Often, their thermal stability demonstrated by thermogravimetry is cited in the literature as important issue. However, little is known about processes occurring in heated solid DNA cationic lipid complexes. In frame of this work, thin films of Deoxyribonucleic acid-hexadecyltrimethylammonium chloride (DNA-CTMA) were deposited on silicon wafers. Samples were thermally annealed, and simultaneously, their optical functions were measured by spectroscopic ellipsometry. At lower temperatures, thermal expansion coefficient of solid DNA-CTMA was negative, but at higher temperatures positive. Thermally induced modification of absorption spectrum in UV-vis was observed. It occurred at a range of temperatures higher than this of DNA denaturation in solution. The observed phenomenon was irreversible, at least in time scale of the experiment (one day).

Kiso Multi-Fiber Spectroscope Project (C)

NASA Astrophysics Data System (ADS)

Yadoumaru, Yasushi; Itoh, Nobunari; Nakada, Yoshikazu; Tarusawa, Ken'ichi; Soyano, Takao; Mito, Hiroyuki

A Multi-FIBER Spectroscope at Kiso Observatory is under consideration as our next instrument. In this paper we report an overview of our instrument and a scientific target of our survey project. We are going to attach multi-fiber system at the prime focus of Kiso 105cm Schmidt telescope. This telescope has some advantages for our project. First, the efficiency in survey for the object, which number density is 0.1 to 10 degree2, is higher than other multi object system due to the wide field of view (6 degree x 6 degree). Second, an optics of telescope is well-matched to fiber numerical aperture (NA) at an input end of fiber. Moreover, taking a focal ratio degradation (FRD) and scrambling property into account, since the light from object dose not move at the entrance slit of spectroscope, we could get spectroscopic data stably with this system. We select a fiber with 100 micron meter core which is correspond to 6 arcsec on focal plane, that is matched with a typical seeing (about 3 arcsec) of Kiso Observatory and set 150 fibers to one field. For efficient observations, it is necessary to arrange fibers accurately within an accuracy of +/- 25 micron meter on the curved focal plane during a typical exposure time (1 hour). Therefore we examine a particular positioner specialized for curved surface. We also develop a spectroscope that is suited for a fast focal ratio and proceed with making its design. One of our main key projects with this system is a non-biased metallicity survey for solar neighbor stars. We are now establishing a new metallicity determination method that easily and reliably measures a metallicity from low-dispersion spectra. (see Itoh et al.). As we consider our main target as Galactic objects and low resolution (R is around 1000), we could observe a star with 17 mag at V-band (1 hour exposure).

Spectroscopic mode identification in gamma Doradus stars

NASA Astrophysics Data System (ADS)

Rylvia Pollard, Karen

2015-08-01

The MUSICIAN programme at the University of Canterbury has been successfully identifying frequencies and pulsation modes in many gamma Doradus stars using hundreds of precise, high resolution spectroscopic observations. This paper describes some of these frequency and mode identifications and the emerging patterns of the programme.

Documenting the Impact of Multisite Evaluations on the Science, Technology, Engineering, and Mathematics Field

ERIC Educational Resources Information Center

Roseland, Denise; Greenseid, Lija O.; Volkov, Boris B.; Lawrenz, Frances

2011-01-01

This chapter discusses the impact that four multisite National Science Foundation (NSF) evaluations had on the broader field of science, technology, engineering, and mathematics education and evaluation. Three approaches were used to investigate the broader impact of these evaluations on the field: (a) a citation analysis, (b) an on-line survey,…

Near-infrared spectroscopic observations of massive young stellar object candidates in the central molecular zone

NASA Astrophysics Data System (ADS)

Nandakumar, G.; Schultheis, M.; Feldmeier-Krause, A.; Schödel, R.; Neumayer, N.; Matteucci, F.; Ryde, N.; Rojas-Arriagada, A.; Tej, A.

2018-01-01

Context. The central molecular zone (CMZ) is a 200 pc region around the Galactic centre. The study of star formation in the central part of the Milky Way is of great interest as it provides a template for the closest galactic nuclei. Aims: We present a spectroscopic follow-up of photometrically selected young stellar object (YSO) candidates in the CMZ of the Galactic centre. Our goal is to quantify the contamination of this YSO sample by reddened giant stars with circumstellar envelopes and to determine the star formation rate (SFR) in the CMZ. Methods: We obtained KMOS low-resolution near-infrared spectra (R 4000) between 2.0 and 2.5 μm of sources, many of which have been previously identified by mid-infrared photometric criteria as massive YSOs in the Galactic centre. Our final sample consists of 91 stars with good signal-to-noise ratio. We separated YSOs from cool late-type stars based on spectral features of CO and Brγ at 2.3 μm and 2.16 μm, respectively. We made use of spectral energy distribution (SED) model fits to the observed photometric data points from 1.25 to 24 μm to estimate approximate masses for the YSOs. Results: Using the spectroscopically identified YSOs in our sample, we confirm that existing colour-colour diagrams and colour-magnitude diagrams are unable to efficiently separate YSOs and cool late-type stars. In addition, we define a new colour-colour criterion that separates YSOs from cool late-type stars in the H-KS vs. H -[8.0] diagram. We use this new criterion to identify YSO candidates in the |l| < 1.̊5, |b| < 0.̊5, region and use model SED fits to estimate their approximate masses. By assuming an appropriate initial mass function (IMF) and extrapolating the stellar IMF down to lower masses, we determine a SFR of 0.046 ± 0.026 M⊙ yr-1 assuming an average age of 0.75 ± 0.25 Myr for the YSOs. This value is lower than estimates found using the YSO counting method in the literature. Conclusions: Our SFR estimate in the CMZ agrees

Analysis Of The ATV1 Re-Entry Using Near-UV Spectroscopic Data From The ESA/NASA Multi-Instrument Aircraft Observation Campaign

NASA Astrophysics Data System (ADS)

Lohle, Stefan; Marynowski, Thomas; Knapp, Andreas; Wernitz, Ricarda; Lips, Tobias

2011-05-01

The first Automated Transfer Vehicle (ATV1) named Jules Verne was launched in March 2009 to carry over seven tons of experiments, fuel, water, food and other supplies to the International Space Station (ISS) orbiting at about 350 km. Attached to the ISS, it served as an extension to the space station, giving extra space for the six astronauts and cosmonauts who will ultimately form the permanent ISS Crew. On September 29, 2009, a controlled de-orbit maneuver lead the spacecraft to enter the Earth's atmosphere over the south pacific ocean. The following destructive re-entry was observed by two aircraft equipped with a wide variety of imaging and spectroscopic instruments. In this paper, we present quantitative results from the near-UV spectroscopic measurements acquired aboard an experimental DC-8 aircraft operated by NASA. The wavelength range of observation allows a determination of temperatures from radiation and the investigation of atomic radiation with respect to the identification of the destructive process. Furthermore, the excitation temperatures of chromium give an insight into the explosive events occurring during re-entry. Analysing the continuum of the measured spectra, the Planck radiation temperature is fitted to the data. These temperatures indicate that most of the radiating parts are titanium alloys, i.e. the outer structure of ATV1. All results within this paper are compared to a simulated break-up scenario and related to basic results from other experimenters which allows drawing an overall scenario for this destructive re-entry.

Spectroscopic Classifications of Optical Transients with Mayall/KOSMOS

NASA Astrophysics Data System (ADS)

Kilpatrick, C. D.; Pan, Y.-C.; Foley, R. J.; Jha, S. W.; Rest, A.; Scolnic, D.

2017-01-01

We report the following classifications of optical transients from spectroscopic observations with KOSMOS on the KPNO Mayall 4-m telescope. Targets were supplied by the All-Sky Automated Survey for Supernovae (ASAS-SN) and the ATLAS project (ATel #8680).

Single nanoparticle tracking spectroscopic microscope

DOEpatents

Yang, Haw [Moraga, CA; Cang, Hu [Berkeley, CA; Xu, Cangshan [Berkeley, CA; Wong, Chung M [San Gabriel, CA

2011-07-19

A system that can maintain and track the position of a single nanoparticle in three dimensions for a prolonged period has been disclosed. The system allows for continuously imaging the particle to observe any interactions it may have. The system also enables the acquisition of real-time sequential spectroscopic information from the particle. The apparatus holds great promise in performing single molecule spectroscopy and imaging on a non-stationary target.

A microfluidic brain slice perfusion chamber for multisite recording using penetrating electrodes.

PubMed

Blake, Alexander J; Rodgers, Frank C; Bassuener, Anna; Hippensteel, Joseph A; Pearce, Thomas M; Pearce, Timothy R; Zarnowska, Ewa D; Pearce, Robert A; Williams, Justin C

2010-05-30

To analyze the spatiotemporal dynamics of network activity in a brain tissue slice, it is useful to record simultaneously from multiple locations. When obtained from laminar structures such as the hippocampus or neocortex, multisite recordings also yield information about subcellular current distributions via current source density analysis. Multisite probes developed for in vivo recordings could serve these purposes in vitro, allowing recordings to be obtained from brain slices at sites deeper within the tissue than currently available surface recording methods permit. However, existing recording chambers do not allow for the insertion of lamina-spanning probes that enter through the edges of brain slices. Here, we present a novel brain slice recording chamber design that accomplishes this goal. The device provides a stable microfluidic perfusion environment in which tissue health is optimized by superfusing both surfaces of the slice. Multichannel electrodes can be inserted parallel to the surface of the slice, at any depth relative to the surface. Access is also provided from above for the insertion of additional recording or stimulating electrodes. We illustrate the utility of this recording configuration by measuring current sources and sinks during theta burst stimuli that lead to the induction of long-term potentiation in hippocampal slices. (c) 2010 Elsevier B.V. All rights reserved.

Potential interoperability problems facing multi-site radiation oncology centers in The Netherlands

NASA Astrophysics Data System (ADS)

Scheurleer, J.; Koken, Ph; Wessel, R.

2014-03-01

Aim: To identify potential interoperability problems facing multi-site Radiation Oncology (RO) departments in the Netherlands and solutions for unambiguous multi-system workflows. Specific challenges confronting the RO department of VUmc (RO-VUmc), which is soon to open a satellite department, were characterized. Methods: A nationwide questionnaire survey was conducted to identify possible interoperability problems and solutions. Further detailed information was obtained by in-depth interviews at 3 Dutch RO institutes that already operate in more than one site. Results: The survey had a 100% response rate (n=21). Altogether 95 interoperability problems were described. Most reported problems were on a strategic and semantic level. The majority were DICOM(-RT) and HL7 related (n=65), primarily between treatment planning and verification systems or between departmental and hospital systems. Seven were identified as being relevant for RO-VUmc. Departments have overcome interoperability problems with their own, or with tailor-made vendor solutions. There was little knowledge about or utilization of solutions developed by Integrating the Healthcare Enterprise Radiation Oncology (IHE-RO). Conclusions: Although interoperability problems are still common, solutions have been identified. Awareness of IHE-RO needs to be raised. No major new interoperability problems are predicted as RO-VUmc develops into a multi-site department.

Reliability of an fMRI Paradigm for Emotional Processing in a Multisite Longitudinal Study

PubMed Central

Gee, Dylan G.; McEwen, Sarah C.; Forsyth, Jennifer K.; Haut, Kristen M.; Bearden, Carrie E.; Addington, Jean; Goodyear, Bradley; Cadenhead, Kristin S.; Mirzakhanian, Heline; Cornblatt, Barbara A.; Olvet, Doreen; Mathalon, Daniel H.; McGlashan, Thomas H.; Perkins, Diana O.; Belger, Aysenil; Seidman, Larry J.; Thermenos, Heidi; Tsuang, Ming T.; van Erp, Theo G.M.; Walker, Elaine F.; Hamann, Stephan; Woods, Scott W.; Constable, Todd; Cannon, Tyrone D.

2015-01-01

Multisite neuroimaging studies can facilitate the investigation of brain-related changes in many contexts, including patient groups that are relatively rare in the general population. Though multisite studies have characterized the reliability of brain activation during working memory and motor functional magnetic resonance imaging tasks, emotion processing tasks, pertinent to many clinical populations, remain less explored. A traveling participants study was conducted with eight healthy volunteers scanned twice on consecutive days at each of the eight North American Longitudinal Prodrome Study sites. Tests derived from generalizability theory showed excellent reliability in the amygdala (Eρ2=0.82), inferior frontal gyrus (IFG;Eρ2=0.83), anterior cingulate cortex (ACC;Eρ2=0.76), insula (Eρ2=0.85), and fusiform gyrus (Eρ2=0.91) for maximum activation and fair to excellent reliability in the amygdala (Eρ2=0.44), IFG (Eρ2=0.48), ACC (Eρ2=0.55), insula (Eρ2=0.42), and fusiform gyrus (Eρ2=0.83) for mean activation across sites and test days. For the amygdala, habituation (Eρ2=0.71) was more stable than mean activation. In a second investigation, data from 111 healthy individuals across sites were aggregated in a voxelwise, quantitative meta-analysis. When compared with a mixed effects model controlling for site, both approaches identified robust activation in regions consistent with expected results based on prior single-site research. Overall, regions central to emotion processing showed strong reliability in the traveling participants study and robust activation in the aggregation study. These results support the reliability of blood oxygen level-dependent signal in emotion processing areas across different sites and scanners and may inform future efforts to increase efficiency and enhance knowledge of rare conditions in the population through multisite neuroimaging paradigms. PMID:25821147

Spectroscopic Classifications of Optical Transients with Keck I/LRIS

NASA Astrophysics Data System (ADS)

Foley, R. J.; Rojas-Bravo, C.

2018-05-01

We report the following classifications of optical transients from spectroscopic observations with LRIS on the Keck I 10-m telescope. Targets were supplied by the ASAS-SN and PSH. All observations were made on 2018 May 10 UT. Classifications were performed with SNID (Blondin & Tonry, 2007, ApJ, 666, 1024).

Time-Series Spectroscopy and Photometry of the Helium Atmosphere Pulsating White Dwarf EC 20058-5234

NASA Astrophysics Data System (ADS)

Sullivan, D. J.

2017-03-01

We summarise both photometric and spectroscopic observations of the southern DBV white dwarf EC 20058-5234 (QU Tel) obtained primarily using a Magellan 6.5 m telescope. With the aim of identifying pulsation-induced spectral variations, the time-resolved 30 sMagellan spectra are phased using 54 h of contiguous time-series photometry obtained using the Mt John (NZ) 1.0 m telescope. A comparison of the DFTs obtained from a 1997 nine day multisite WET run and the two day single site Magellan observations is made. The difficulty of establishing a reliable surface temperatures for DBVs is mentioned.

Spectroscopic Classifications of Optical Transients with Mayall/KOSMOS

NASA Astrophysics Data System (ADS)

Pan, Y.-C.; Kilpatrick, C. D.; Siebert, M. R.; Foley, R. J.; Jha, S. W.; Rest, A.; Scolnic, D.

2016-08-01

We report the following classifications of optical transients from spectroscopic observations with KOSMOS on the KPNO Mayall 4-m telescope. Targets were supplied by the Pan-STARRS Survey for Transients (PSST) and the All-Sky Automated Survey for Supernovae (ASAS-SN).

Spectroscopic Classifications of Optical Transients with Mayall/KOSMOS

NASA Astrophysics Data System (ADS)

Pan, Y.-C.; Foley, R. J.; Jha, S. W.; Rest, A.; Scolnic, D.

2016-06-01

We report the following classifications of optical transients from spectroscopic observations with KOSMOS on the KPNO Mayall 4-m telescope. Targets were supplied by the Pan-STARRS Survey for Transients (PSST), All-Sky Automated Survey for Supernovae (ASAS-SN) and MASTER.

Finding Efficiency in the Design of Large Multisite Evaluations: Estimating Variances for Science Achievement Studies

ERIC Educational Resources Information Center

Westine, Carl D.

2016-01-01

Little is known empirically about intraclass correlations (ICCs) for multisite cluster randomized trial (MSCRT) designs, particularly in science education. In this study, ICCs suitable for science achievement studies using a three-level (students in schools in districts) MSCRT design that block on district are estimated and examined. Estimates of…

Spectroscopic observations of comets

NASA Technical Reports Server (NTRS)

1982-01-01

Development of a spectrograph using a microchannel plate intensifier for observing faint comets is described. The spectrograph is capable of obtaining useful spectra of objects as faint as M(2) = 18. The increased guiding efficiency achieved by the optical coupling of the ISIT vidicon of the 154 cm telescope has resulted in a better signal to noise ratio. The ability to take a direct image of the comet aids in the interpretation of the spatial profile of the emissions. Spectra of comets Schwassmann-Wachmann 1, Bradfield, Encke, Tuttle, and Stephen-Oterma are discussed.

Research staff training in a multisite randomized clinical trial: Methods and recommendations from the Stimulant Reduction Intervention using Dosed Exercise (STRIDE) trial.

PubMed

Walker, Robrina; Morris, David W; Greer, Tracy L; Trivedi, Madhukar H

2014-01-01

Descriptions of and recommendations for meeting the challenges of training research staff for multisite studies are limited despite the recognized importance of training on trial outcomes. The STRIDE (STimulant Reduction Intervention using Dosed Exercise) study is a multisite randomized clinical trial that was conducted at nine addiction treatment programs across the United States within the National Drug Abuse Treatment Clinical Trials Network (CTN) and evaluated the addition of exercise to addiction treatment as usual (TAU), compared to health education added to TAU, for individuals with stimulant abuse or dependence. Research staff administered a variety of measures that required a range of interviewing, technical, and clinical skills. In order to address the absence of information on how research staff are trained for multisite clinical studies, the current manuscript describes the conceptual process of training and certifying research assistants for STRIDE. Training was conducted using a three-stage process to allow staff sufficient time for distributive learning, practice, and calibration leading up to implementation of this complex study. Training was successfully implemented with staff across nine sites. Staff demonstrated evidence of study and procedural knowledge via quizzes and skill demonstration on six measures requiring certification. Overall, while the majority of staff had little to no experience in the six measures, all research assistants demonstrated ability to correctly and reliably administer the measures throughout the study. Practical recommendations are provided for training research staff and are particularly applicable to the challenges encountered with large, multisite trials.

A modified potential for HO2 with spectroscopic accuracy

NASA Astrophysics Data System (ADS)

Brandão, João; Rio, Carolina M. A.; Tennyson, Jonathan

2009-04-01

Seven ground state potential energy surfaces for the hydroperoxyl radical are compared. The potentials were determined from either high-quality ab initio calculations, fits to spectroscopic data, or a combination of the two approaches. Vibration-rotation calculations are performed on each potential and the results compared with experiment. None of the available potentials is entirely satisfactory although the best spectroscopic results are obtained using the Morse oscillator rigid bender internal dynamics potential [Bunker et al., J. Mol. Spectrosc. 155, 44 (1992)]. We present modifications of the double many-body expansion IV potential of Pastrana et al. [J. Chem. Phys. 94, 8093 (1990)]. These new potentials reproduce the observed vibrational levels and observed vibrational levels and rotational constants, respectively, while preserving the good global properties of the original potential.

Provider perceptions of knowledge exchange and communication in a multisite family health team

PubMed Central

Slater, Morgan; Nicholas, Emily; Leung, Fok-Han; Lofters, Aisha

2016-01-01

Abstract Objective To describe providers’ self-reported knowledge and use of family health team (FHT) services and to explore attitudes and perspectives about communication issues among health care professionals active within a large multisite FHT. Design Electronic questionnaire. Setting A multisite FHT in Toronto, Ont. Participants Health care professionals active within the FHT (N = 90). Main outcome measures The survey captured demographic characteristics, including the respondents’ roles and experience; knowledge about services available within the FHT; use of services; and perceived communication issues within the FHT. Results Forty-six health care professionals participated (51% response rate). While respondents were highly aware of the clinical resources and services offered at their own site of practice (95% agreed or strongly agreed), only 54% were aware of services offered at other sites within the FHT. Internal referrals for certain specialty services were high (ie, methadone management, obstetric care, intrauterine device insertion, and psychiatry), but less than 50% of other referrals (ie, sports medicine, joint injections, or tropical medicine) were to physicians within the FHT, despite physicians within the FHT offering services in these areas of expertise. Only 60% of respondents believed that patients had equal access to all of the services within the FHT, and 42% agreed or strongly agreed that patients were unlikely to travel between sites to access services. Roughly one-quarter of respondents believed that physicians were unlikely to refer patients to another site within the FHT to receive health care services. Most respondents agreed that the geographic distribution of the sites negatively affected communication within the FHT (68% agreed or strongly agreed). Conclusion Geographic dispersion of team members in a multisite FHT had a negative effect on provider knowledge of available services, perceived patient access to services, and

Spectroscopic Classifications of Optical Transients with Mayall/KOSMOS

NASA Astrophysics Data System (ADS)

Siebert, M. R.; Pan, Y.-C.; Kilpatrick, C. D.; Foley, R. J.

2017-07-01

We report the following classifications of optical transients from spectroscopic observations with KOSMOS on the KPNO Mayall 4-m telescope. Targets were supplied by the Asteroid Terrestrial-impact Last Alert System (ATLAS; ATel #8680), the Pan-STARRS Survey for Transients (PSST) and Gaia.

Spectroscopy of γ Doradus stars

NASA Astrophysics Data System (ADS)

Brunsden, E.; Pollard, K. R.; Cottrell, P. L.; Wright, D. J.; De Cat, P.; Kilmartin, P. M.

2014-02-01

The musician programme at the University of Canterbury has been successfully identifying pulsation modes in many γ Doradus stars using hundreds of ground-based spectroscopic observations. This paper describes some of the successful mode identifications and emerging patterns of the programme. The hybrid γ Doradus/δ Scuti star HD 49434 remains an enigma, despite the analysis of more than 1700 multi-site high-resolution spectra. A new result for this star is apparently distinct line-profile variations for the γ Doradus and δ Scuti frequencies.

Multi-Site Ethnography, Hypermedia and the Productive Hazards of Digital Methods: A Struggle for Liveness

ERIC Educational Resources Information Center

Gallagher, Kathleen; Freeman, Barry

2011-01-01

This article explores the possibilities and frustrations of using digital methods in a multi-sited ethnographic research project. The project, "Urban School Performances: The interplay, through live and digital drama, of local-global knowledge about student engagement", is a study of youth and teachers in drama classrooms in contexts of…

The Peculiar Institution?: A Multisite Case Study of Athletic Department Cultures at Small Christian Institutions

ERIC Educational Resources Information Center

Ramseyer, Paul Robert

2017-01-01

This multisite case study explored the perceptions of athletic department members of the important factors of organizational cultures in athletic departments at small Christian institutions in the Midwestern United States. The study comprised of site visits to three small Christian institutions in the Midwestern United States. At each site, six…

Spectroscopic Classifications of Optical Transients with the Lick Shane telescope

NASA Astrophysics Data System (ADS)

Rojas-Bravo, C.; Xhakaj, E.; Pan, Y.-C.; Kilpatrick, C. D.; Foley, R. J.

2017-07-01

We report the following classifications of optical transients from spectroscopic observations with the Kast spectrograph on the Shane telescope. Targets were supplied by ASAS-SN, ATLAS, Gaia, and POSS.

ATel 7534: Spectroscopic Classifications of Optical Transients with Mayall/KOSMOS

NASA Astrophysics Data System (ADS)

Pan, Y.-C.; Foley, R. J.; Downing, S.; Jha, S. W.; Rest, A.; Scolnic, D.; Smith, K. W.; Wright, D.; Smartt, S. J.; Huber, M.; Chambers, K. C.; Flewelling, H.; Willman, M.; Primak, N.; Schultz, A.; Gibson, B.; Magnier, E.; Waters, C.; Tonry, J.; Wainscoat, R. J.

2015-05-01

We report the following classifications of optical transients from spectroscopic observations with the KOSMOS on the Mayall telescope. Targets were supplied by the Pan-STARRS Survey for Transients (PSST). ...

{sup 13}C-METHYL FORMATE: OBSERVATIONS OF A SAMPLE OF HIGH-MASS STAR-FORMING REGIONS INCLUDING ORION-KL AND SPECTROSCOPIC CHARACTERIZATION

DOE Office of Scientific and Technical Information (OSTI.GOV)

Favre, Cécile; Bergin, Edwin A.; Crockett, Nathan R.

2015-01-01

We have surveyed a sample of massive star-forming regions located over a range of distances from the Galactic center for methyl formate, HCOOCH{sub 3}, and its isotopologues H{sup 13}COOCH{sub 3} and HCOO{sup 13}CH{sub 3}. The observations were carried out with the APEX telescope in the frequency range 283.4-287.4 GHz. Based on the APEX observations, we report tentative detections of the {sup 13}C-methyl formate isotopologue HCOO{sup 13}CH{sub 3} toward the following four massive star-forming regions: Sgr B2(N-LMH), NGC 6334 IRS 1, W51 e2, and G19.61-0.23. In addition, we have used the 1 mm ALMA science verification observations of Orion-KL and confirm the detection ofmore » the {sup 13}C-methyl formate species in Orion-KL and image its spatial distribution. Our analysis shows that the {sup 12}C/{sup 13}C isotope ratio in methyl formate toward the Orion-KL Compact Ridge and Hot Core-SW components (68.4 ± 10.1 and 71.4 ± 7.8, respectively) are, for both the {sup 13}C-methyl formate isotopologues, commensurate with the average {sup 12}C/{sup 13}C ratio of CO derived toward Orion-KL. Likewise, regarding the other sources, our results are consistent with the {sup 12}C/{sup 13}C in CO. We also report the spectroscopic characterization, which includes a complete partition function, of the complex H{sup 13}COOCH{sub 3} and HCOO{sup 13}CH{sub 3} species. New spectroscopic data for both isotopomers H{sup 13}COOCH{sub 3} and HCOO{sup 13}CH{sub 3}, presented in this study, have made it possible to measure this fundamentally important isotope ratio in a large organic molecule for the first time.« less

Asiago spectroscopic classification of six optical transients

NASA Astrophysics Data System (ADS)

Tomasella, L.; Benetti, S.; Cappellaro, E.; Elias-Rosa, N.; Ochner, P.; Pastorello, A.; Tartaglia, L.; Terreran, G.; Turatto, M.

2015-01-01

The Asiago Transient Classification Program (Tomasella et al. 2014, AN, 335, 841) reports the spectroscopic observation of the following transients. Targets were supplied by the Astronomy Section of the Rochester Academy of Sciences (arXiv:1103.5165), the CBAT Transient Objects Confirmation Page (TOCP) and the Gaia Photometric Science Alerts (validation phase).

Spectroscopic Classifications of AT2016esx with Mayall/KOSMOS

NASA Astrophysics Data System (ADS)

Kilpatrick, C. D.; Siebert, M. R.; Coulter, D. A.; Foley, R. J.; Pan, Y.-C.; Jha, S. W.; Rest, A.; Scolnic, D.

2016-08-01

We report a classification of ASASSN-16io = AT2016esx from spectroscopic observations with KOSMOS on the KPNO Mayall 4-m telescope. Targets were supplied by the All-Sky Automated Survey for Supernovae (ASAS-SN).

ePESSTO spectroscopic classification of the candidate TDE XMMSL2 J140446.9-251135

NASA Astrophysics Data System (ADS)

Taubenberger, S.; Floers, A.; Vogl, C.; Benetti, S.; Pastorello, A.; Cappellaro, E.; Anderson, J.; Gromadzki, M.; Onori, F.; Kostrzewa-Rutkowska, Z.; Jonker, P.; Leloudas, G.; Inserra, C.; Kankare, E.; Maguire, K.; Smartt, S. J.; Yaron, O.; Young, D.

2018-03-01

ePESSTO, the extended Public ESO Spectroscopic Survey for Transient Objects (see Smartt et al. 2015, A & A, 579, 40; http://www.pessto.org ), reports the following spectroscopic observation of the new X-ray source XMMSL2 J140446.9-251135 in the galaxy 2MASX 14044671-2511433 (ATel #11394).

Spectroscopic Classifications of Optical Transients with Mayall/KOSMOS

NASA Astrophysics Data System (ADS)

Pan, Y.-C.; Downing, S.; Foley, R. J.; Jha, S. W.; Rest, A.; Scolnic, D.

2016-01-01

We report the following classifications of optical transients from spectroscopic observations with the KOSMOS on the Mayall telescope. Targets were supplied by the All-Sky Automated Survey for Supernovae (ASAS-SN), Catalina Real-Time Transient Survey (CRTS) and the CBAT Transient Object Followup Reports.

Spectroscopic and photometric observations of M supergiants in Carina.

NASA Technical Reports Server (NTRS)

Humphreys, R. M.; Strecker, D. W.; Ney, E. P.

1972-01-01

Spectroscopic study of 30 Southern-Hemisphere M supergiants mostly in Carina in the blue and near-infrared, and photometrical study of these stars from 0.4 to 18 microns. The uncertainties in the determinations of interstellar extinction are discussed, and the spatial distribution of the M supergiants in the Carina arm is shown. The presence of the 11-micron excess attributed to silicate dust is a common feature. Stars of the same spectral type and luminosity class are remarkably homogeneous in their long-wave behavior. The silicate feature becomes more prominent in the more luminous stars and in stars of later spectral type. Four composite systems show little long-wave excess. The two VV Cephei objects have excesses probably produced by gas emission, and the other two have little or no excess - supporting the suggestion that the presence of the early star prohibits the formation of a dust envelope. Three stars - VY CMa, VX Sgr, and HD 9767 - appear to be extreme examples of stars with large excesses over the entire long-wave region. It is suggested that these objects are surrounded by large amounts of particulate material over a great range of distances from the stars.

Spectroscopic Observations of the Outflowing Wind in the Lensed Quasar SDSS J1001+5027

NASA Astrophysics Data System (ADS)

Misawa, Toru; Inada, Naohisa; Oguri, Masamune; Charlton, Jane C.; Eracleous, Michael; Koyamada, Suzuka; Itoh, Daisuke

2018-02-01

We performed spectroscopic observations of the small-separation lensed quasar SDSS J1001+5027, whose images have an angular separation θ =2\\buildrel{\\prime\\prime}\\over{.} 86, and placed constraints on the physical properties of gas clouds in the vicinity of the quasar (i.e., in the outflowing wind launched from the accretion disk). The two cylinders of sight to the two lensed images go through the same region of the outflowing wind and they become fully separated with no overlap at a very large distance from the source (∼330 pc). We discovered a clear difference in the profile of the C IV broad absorption line (BAL) detected in the two lensed images in two observing epochs. Because the kinematic components in the BAL profile do not vary in concert, the observed variations cannot be reproduced by a simple change of ionization state. If the variability is due to gas motion around the background source (i.e., the continuum source), the corresponding rotational velocity is {v}rot} ≥ 18,000 km s‑1, and their distance from the source is r≤slant 0.06 pc assuming Keplerian motion. Among three Mg II and three C IV NAL systems that we detected in the spectra, only the Mg II system at {z}abs} = 0.8716 shows a hint of variability in its Mg I profile on a rest-frame timescale of {{Δ }}{t}rest} ≤slant 191 days and an obvious velocity shear between the sightlines whose physical separation is ∼7 kpc. We interpret this as the result of motion of a cosmologically intervening absorber, perhaps located in a foreground galaxy. Based on data collected at the Subaru Telescope, which is operated by the National Astronomical Observatory of Japan.

Development and Implementation of a Multisite Evaluation for the Women, Co-Occurring Disorders and Violence Study

ERIC Educational Resources Information Center

Giard, Julienne; Hennigan, Karen; Huntington, Nicholas; Vogel, Wendy; Rinehart, Debbie; Mazelis, Ruta; Nadlicki, Terri; Veysey, Bonita M.

2005-01-01

In this article we describe the development and implementation of the Substance Abuse and Mental Health Services Administration's (SAMHSA's) multisite Women, Co-Occurring Disorders and Violence Study (WCDVS), highlighting some of the challenges encountered, decisions made, and lessons learned. Four themes are discussed. First, the unique…

The most metal-poor Galactic globular cluster: the first spectroscopic observations of ESO280-SC06

NASA Astrophysics Data System (ADS)

Simpson, Jeffrey D.

2018-07-01

We present the first spectroscopic observations of the very metal-poor Milky Way globular cluster ESO280-SC06. Using spectra acquired with the 2dF/AAOmega spectrograph on the Anglo-Australian Telescope, we have identified 13 members of the cluster, and estimate from their infrared calcium triplet lines that the cluster has a metallicity of [Fe/H]=-2.48^{+0.06 }_{ -0.11}. This would make it the most metal-poor globular cluster known in the Milky Way. This result was verified with comparisons to three other metal-poor globular clusters that had been observed and analysed in the same manner. We also present new photometry of the cluster from EFOSC2 and SkyMapper and confirm that the cluster is located 22.9 ± 2.1 kpc from the Sun and 15.2 ± 2.1 kpc from the Galactic Centre, and has a radial velocity of 92.5^{+2.4 }_{ -1.6} km s-1. These new data finds the cluster to have a radius about half that previously estimated, and we find that the cluster has a dynamical mass of the cluster of (12 ± 2) × 103 M⊙. Unfortunately, we lack reliable proper motions to fully characterize its orbit about the Galaxy. Intriguingly, the photometry suggests that the cluster lacks a well-populated horizontal branch, something that has not been observed in a cluster so ancient or metal poor.

The most metal-poor Galactic globular cluster: the first spectroscopic observations of ESO280-SC06

NASA Astrophysics Data System (ADS)

Simpson, Jeffrey D.

2018-04-01

We present the first spectroscopic observations of the very metal-poor Milky Way globular cluster ESO280-SC06. Using spectra acquired with the 2dF/AAOmega spectrograph on the Anglo-Australian Telescope, we have identified 13 members of the cluster, and estimate from their infrared calcium triplet lines that the cluster has a metallicity of [Fe/H]={-2.48}^{+0.06}_{-0.11}. This would make it the most metal-poor globular cluster known in the Milky Way. This result was verified with comparisons to three other metal-poor globular clusters that had been observed and analyzed in the same manner. We also present new photometry of the cluster from EFOSC2 and SkyMapper and confirm that the cluster is located 22.9 ± 2.1 kpc from the Sun and 15.2 ± 2.1 kpc from the Galactic centre, and has a radial velocity of 92.5 + 2.4-1.6 km s-1. These new data finds the cluster to have a radius about half that previously estimated, and we find that the cluster has a dynamical mass of the cluster of (12 ± 2) × 103 M⊙. Unfortunately, we lack reliable proper motions to fully characterize its orbit about the Galaxy. Intriguingly, the photometry suggests that the cluster lacks a well-populated horizontal branch, something that has not been observed in a cluster so ancient or metal-poor.

Spectroscopic Classifications of Optical Transients with Mayall/KOSMOS

NASA Astrophysics Data System (ADS)

Kilpatrick, C. D.; Pan, Y.-C.; Foley, R. J.; Jha, S. W.; Rest, A.; Scolnic, D.

2017-02-01

We report the following classifications of optical transients from spectroscopic observations with KOSMOS on the KPNO Mayall 4-m telescope. Targets were supplied by the All-Sky Automated Survey for Supernovae (ASAS-SN), the ATLAS project (ATel #8680), and the Pan-STARRS Survey for Transients (PSST).

Spectroscopic Classification of Seven Supernovae

NASA Astrophysics Data System (ADS)

Blanchard, P.; Gomez, S.; Nicholl, M.; Berger, E.

2018-01-01

We obtained optical spectroscopic observations of 7 transients reported to the Transient Name Server by the ATLAS survey (Tonry et al. 2011, PASP, 123, 58; Tonry et al., ATel #8680), the Pan-STARRS Survey for Transients (PSST; Huber et al., ATel #7153; http://star.pst.qub.ac.uk/ps1threepi/), DPAC and the ESA Gaia Photometric Science Alerts Team (http://gsaweb.ast.cam.ac.uk/alerts), and the Tsinghua University-National Astronomical Observatories of China Transient Survey (TNTS).

MultiSite Gateway-Compatible Cell Type-Specific Gene-Inducible System for Plants1[OPEN

PubMed Central

Siligato, Riccardo; Wang, Xin; Yadav, Shri Ram; Lehesranta, Satu; Ma, Guojie; Ursache, Robertas; Sevilem, Iris; Zhang, Jing; Gorte, Maartje; Prasad, Kalika; Heidstra, Renze

2016-01-01

A powerful method to study gene function is expression or overexpression in an inducible, cell type-specific system followed by observation of consequent phenotypic changes and visualization of linked reporters in the target tissue. Multiple inducible gene overexpression systems have been developed for plants, but very few of these combine plant selection markers, control of expression domains, access to multiple promoters and protein fusion reporters, chemical induction, and high-throughput cloning capabilities. Here, we introduce a MultiSite Gateway-compatible inducible system for Arabidopsis (Arabidopsis thaliana) plants that provides the capability to generate such constructs in a single cloning step. The system is based on the tightly controlled, estrogen-inducible XVE system. We demonstrate that the transformants generated with this system exhibit the expected cell type-specific expression, similar to what is observed with constitutively expressed native promoters. With this new system, cloning of inducible constructs is no longer limited to a few special cases but can be used as a standard approach when gene function is studied. In addition, we present a set of entry clones consisting of histochemical and fluorescent reporter variants designed for gene and promoter expression studies. PMID:26644504

Spectroscopic Observations of a Solar Flare and the Associated Coronal Mass Ejection

NASA Astrophysics Data System (ADS)

Murray, S.; Tian, H.; McKillop, S.

2013-12-01

We used data from the EUV Imaging Spectrometer (EIS) on board Hinode to examine a coronal mass ejection and a preceding flare observed on 21 November 2012 between 15:00 and 17:00 UT. Images from the Atmospheric Imaging Assembly on the Solar Dynamics Observatory were used to align the data from EIS with specific events occurring. We analyzed spectra of a few emission lines at three locations on the flare site and one location in the erupting prominence. On the flare site, we found line profiles showing typical characteristics of chromospheric evaporation: downflows at cooler lines and upflows at hotter lines. At one particular location on the flare site, we clearly identified dominant downflows on the order of 100 km/s in lines through Fe VIII to Fe XVI. To the best of our knowledge, this is the first time that such strong high-speed downflows have been spectroscopically observed in the impulsive phase of solar flares. The profile of the Fe VIII 184.54 line reveals two peaks and we were able to use the double Gaussian fit to separate the rapid downflows of dense material from the nearly stationary coronal background emission. For the erupting prominence, we were able to analyze multiple lines, cooler and warmer, of interest using this double Gaussian fit to separate the background emission from the emission of the ejected material. Our results show that the LOS velocities of the ejected material are about 100 km/s in the lower corona. Additionally, in each region of interest, we used the ratio of the density-sensitive line pair FeXII 195/186 to determine the electron density. Our results clearly show that the coronal densities were greatly enhanced during the flare. The density of the ejected material is also much larger than the typical coronal density. This research was supported by the NSF grant for the Solar Physics REU Program at the Smithsonian Astrophysical Observatory (AGS-1263241).

13C-Methyl Formate: Observations of a Sample of High-mass Star-forming Regions Including orion-KL and Spectroscopic Characterization

NASA Astrophysics Data System (ADS)

Favre, Cécile; Carvajal, Miguel; Field, David; Jørgensen, Jes K.; Bisschop, Suzanne E.; Brouillet, Nathalie; Despois, Didier; Baudry, Alain; Kleiner, Isabelle; Bergin, Edwin A.; Crockett, Nathan R.; Neill, Justin L.; Margulès, Laurent; Huet, Thérèse R.; Demaison, Jean

2014-12-01

We have surveyed a sample of massive star-forming regions located over a range of distances from the Galactic center for methyl formate, HCOOCH3, and its isotopologues H13COOCH3 and HCOO13CH3. The observations were carried out with the APEX telescope in the frequency range 283.4-287.4 GHz. Based on the APEX observations, we report tentative detections of the 13C-methyl formate isotopologue HCOO13CH3 toward the following four massive star-forming regions: Sgr B2(N-LMH), NGC 6334 IRS 1, W51 e2, and G19.61-0.23. In addition, we have used the 1 mm ALMA science verification observations of Orion-KL and confirm the detection of the 13C-methyl formate species in Orion-KL and image its spatial distribution. Our analysis shows that the 12C/13C isotope ratio in methyl formate toward the Orion-KL Compact Ridge and Hot Core-SW components (68.4 ± 10.1 and 71.4 ± 7.8, respectively) are, for both the 13C-methyl formate isotopologues, commensurate with the average 12C/13C ratio of CO derived toward Orion-KL. Likewise, regarding the other sources, our results are consistent with the 12C/13C in CO. We also report the spectroscopic characterization, which includes a complete partition function, of the complex H13COOCH3 and HCOO13CH3 species. New spectroscopic data for both isotopomers H13COOCH3 and HCOO13CH3, presented in this study, have made it possible to measure this fundamentally important isotope ratio in a large organic molecule for the first time. This publication is based on data acquired with the Atacama Pathfinder Experiment (APEX). APEX is a collaboration between the Max-Planck-Institut fur Radioastronomie, the European Southern Observatory, and the Onsala Space Observatory (under program ID 089.F-9319).

Methodological challenges in conducting a multi-site randomized clinical trial of massage therapy in hospice.

PubMed

Kutner, Jean; Smith, Marlaine; Mellis, Karen; Felton, Sue; Yamashita, Traci; Corbin, Lisa

2010-06-01

Researchers conducting multi-site studies of interventions for end-of-life symptom management face significant challenges with respect to obtaining an adequate sample and training and retaining on-site study teams. The purpose of this paper is to describe the strategies and responses to these challenges in a multi-site randomized clinical trial (RCT) of the efficacy of massage therapy for decreasing pain among patients with advanced cancer in palliative care/hospice settings. Over a period of 36 months, we enrolled 380 participants across 15 sites; 27% of whom withdrew prior to study completion (less than the anticipated 30% rate). We saw an average of 68% turnover amongst study staff. Three key qualities characterized successful on-site study teams: (1) organizational commitment; (2) strong leadership from on-site study coordinators; and (3) effective lines of communication between the on-site study coordinators and both their teams and the university-based research team. Issues of recruitment, retention and training should be accounted for in hospice-based research study design and budgeting.

The Childhood Obesity Research Demonstration project: a team approach for supporting a multisite, multisector intervention.

PubMed

Williams, Nancy; Dooyema, Carrie A; Foltz, Jennifer L; Belay, Brook; Blanck, Heidi M

2015-02-01

Comprehensive multisector, multilevel approaches are needed to address childhood obesity. This article introduces the structure of a multidisciplinary team approach used to support and guide the multisite, multisector interventions implemented as part of the Childhood Obesity Research Demonstration (CORD) project. This article will describe the function, roles, and lessons learned from the CDC-CORD approach to project management. The CORD project works across multisectors and multilevels in three demonstration communities. Working with principal investigators and their research teams who are engaging multiple stakeholder groups, including community organizations, schools and child care centers, health departments, and healthcare providers, can be a complex endeavor. To best support the community-based research project, scientific and programmatic expertise in a wide range of areas was required. The team was configured based on the skill sets needed to interact with the various levels of staff working with the project. By thoughtful development of the team and processes, an efficient system for supporting the multisite, multisector intervention project sites was developed. The team approach will be formally evaluated at the end of the project period.

Evaluation of Intervention Fidelity in a Multisite Clinical Trial in Persons With Multiple Sclerosis.

PubMed

Morrison, Janet D; Becker, Heather; Stuifbergen, Alexa K

2017-12-01

Careful consideration of intervention fidelity is critical to establishing the validity and reliability of research findings, yet such reports are often lacking in the research literature. It is imperative that intervention fidelity be methodically evaluated and reported to promote the translation of effective interventions into sound evidence-based practice. The purpose of this article is to explore strategies used to promote intervention fidelity, incorporating examples from a multisite clinical trial, that illustrate the National Institutes of Health Behavior Change Consortium's 5 domains for recommended treatment practices: (1) study design, (2) facilitator training, (3) intervention delivery, (4) intervention receipt, and (5) intervention enactment. A multisite randomized clinical trial testing the efficacy of a computer-assisted cognitive rehabilitation intervention for adults with multiple sclerosis is used to illustrate strategies promoting intervention fidelity. Data derived from audiotapes of intervention classes, audits of computer exercises completed by participants, participant class attendance, and goal attainment scaling suggested relatively high fidelity to the intervention protocol. This study illustrates how to report intervention fidelity in the literature guided by best practice strategies, which may serve to promote fidelity monitoring and reporting in future studies.

The GEISA Spectroscopic Database System in its latest Edition

NASA Astrophysics Data System (ADS)

Jacquinet-Husson, N.; Crépeau, L.; Capelle, V.; Scott, N. A.; Armante, R.; Chédin, A.

2009-04-01

GEISA (Gestion et Etude des Informations Spectroscopiques Atmosphériques: Management and Study of Spectroscopic Information)[1] is a computer-accessible spectroscopic database system, designed to facilitate accurate forward planetary radiative transfer calculations using a line-by-line and layer-by-layer approach. It was initiated in 1976. Currently, GEISA is involved in activities related to the assessment of the capabilities of IASI (Infrared Atmospheric Sounding Interferometer on board the METOP European satellite -http://earth-sciences.cnes.fr/IASI/)) through the GEISA/IASI database[2] derived from GEISA. Since the Metop (http://www.eumetsat.int) launch (October 19th 2006), GEISA/IASI is the reference spectroscopic database for the validation of the level-1 IASI data, using the 4A radiative transfer model[3] (4A/LMD http://ara.lmd.polytechnique.fr; 4A/OP co-developed by LMD and Noveltis with the support of CNES). Also, GEISA is involved in planetary research, i.e.: modelling of Titan's atmosphere, in the comparison with observations performed by Voyager: http://voyager.jpl.nasa.gov/, or by ground-based telescopes, and by the instruments on board the Cassini-Huygens mission: http://www.esa.int/SPECIALS/Cassini-Huygens/index.html. The updated 2008 edition of GEISA (GEISA-08), a system comprising three independent sub-databases devoted, respectively, to line transition parameters, infrared and ultraviolet/visible absorption cross-sections, microphysical and optical properties of atmospheric aerosols, will be described. Spectroscopic parameters quality requirement will be discussed in the context of comparisons between observed or simulated Earth's and other planetary atmosphere spectra. GEISA is implemented on the CNES/CNRS Ether Products and Services Centre WEB site (http://ether.ipsl.jussieu.fr), where all archived spectroscopic data can be handled through general and user friendly associated management software facilities. More than 350 researchers are

Speckle and spectroscopic orbits of the early A-type triple system Eta Virginis

NASA Technical Reports Server (NTRS)

Hartkopf, William I.; Mcalister, Harold A.; Yang, Xinxing; Fekel, Francis C.

1992-01-01

Eta Virginis is a bright (V = 3.89) triple system of composite spectral type A2 IV that has been observed for over a dozen years with both spectroscopy and speckle interferometry. Analysis of the speckle observations results in a long period of 13.1 yr. This period is also detected in residuals from the spectroscopic observations of the 71.7919 day short-period orbit. Elements of the long-period orbit were determined separately using the observations of both techniques. The more accurate elements from the speckle solution have been assumed in a simultaneous spectroscopic determination of the short- and long-period orbital elements. The magnitude difference of the speckle components suggests that lines of the third star should be visible in the spectrum.

An Examination of Diversity within Three Southeastern Academic Libraries: A Mixed-Methods, Multi-Site Study

ERIC Educational Resources Information Center

Shaffer, Christopher A.

2014-01-01

The purpose of this study was to determine the extent to which three academic libraries in the Southeastern United States could be considered diverse. This was a multi-site, mixed methods study. It examined the climate and culture of the libraries, which was assessed through two methods; the first, through survey responses from full-time faculty…

Learning "about" and "from" Variation in Program Impacts Using Multisite Trials. MDRC Working Papers on Research Methodology

ERIC Educational Resources Information Center

Raudenbush, Stephen W.; Bloom, Howard S.

2015-01-01

The present paper, which is intended for a diverse audience of evaluation researchers, applied social scientists, and research funders, provides a broad overview of the conceptual and statistical issues involved in using multisite randomized trials to learn "about" and "from" variation in program effects across…

Spectroscopic observation of SN 2017jzp and SN 2018bf by NUTS (NOT Un-biased Transient Survey)

NASA Astrophysics Data System (ADS)

Kuncarayakti, H.; Mattila, S.; Kotak, R.; Harmanen, J.; Reynolds, T.; Wyrzykowski, L.; Stritzinger, M.; Onori, F.; Somero, A.; Kangas, T.; Lundqvist, P.; Taddia, F.; Ergon, M.

2018-01-01

The Nordic Optical Telescope (NOT) Unbiased Transient Survey (NUTS; ATel #8992) reports the spectroscopic classification of SNe 2017jzp and 2018bf in host galaxies KUG 1326+679 and SDSS J225746.53+253833.5, respectively.

Multi-site recording and spectral analysis of spontaneous photon emission from human body.

PubMed

Wijk, Eduard P A Van; Wijk, Roeland Van

2005-04-01

In the past years, research on ultraweak photon emission (UPE) from human body has increased for isolated cells and tissues. However, there are only limited data on UPE from the whole body, in particular from the hands. To describe a protocol for the management of subjects that (1) avoids interference with light-induced longterm delayed luminescence, and (2) includes the time slots for recording photon emission. The protocol was utilised for multi-site recording of 4 subjects at different times of the day and different seasons, and for one subject to complete spectral analysis of emission from different body locations. An especially selected low-noise end-window photomultiplier was utilised for the detection of ultraviolet / visible light (200-650 nm) photon emission. For multi-site recording it was manipulated in three directions in a darkroom with a very low count rate. A series of cut-off filters was used for spectral analysis of UPE. 29 body sites were selected such that the distribution in UPE could be studied as right-left symmetry, dorsal-ventral symmetry, and the ratio between the central body part and extremities. Generally, the fluctuation in photon counts over the body was lower in the morning than in the afternoon. The thorax-abdomen region emitted lowest and most constantly. The upper extremities and the head region emitted most and increasingly over the day. Spectral analysis of low, intermediate and high emission from the superior frontal part of the right leg, the forehead and the palms in the sensitivity range of the photomultiplier showed the major spontaneous emission at 470-570 nm. The central palm area of hand emission showed a larger contribution of the 420-470 nm range in the spectrum of spontaneous emission from the hand in autumn/winter. The spectrum of delayed luminescence from the hand showed major emission in the same range as spontaneous emission. Examples of multi-site UPE recordings and spectral analysis revealed individual patterns

Identification and Spectroscopic Characterization of Nonheme Iron(III) Hypochlorite Intermediates.

PubMed

Draksharapu, Apparao; Angelone, Davide; Quesne, Matthew G; Padamati, Sandeep K; Gómez, Laura; Hage, Ronald; Costas, Miquel; Browne, Wesley R; de Visser, Sam P

2015-03-27

Fe III -hypohalite complexes have been implicated in a wide range of important enzyme-catalyzed halogenation reactions including the biosynthesis of natural products and antibiotics and post-translational modification of proteins. The absence of spectroscopic data on such species precludes their identification. Herein, we report the generation and spectroscopic characterization of nonheme Fe III -hypohalite intermediates of possible relevance to iron halogenases. We show that Fe III -OCl polypyridylamine complexes can be sufficiently stable at room temperature to be characterized by UV/Vis absorption, resonance Raman and EPR spectroscopies, and cryo-ESIMS. DFT methods rationalize the pathways to the formation of the Fe III -OCl, and ultimately Fe IV =O, species and provide indirect evidence for a short-lived Fe II -OCl intermediate. The species observed and the pathways involved offer insight into and, importantly, a spectroscopic database for the investigation of iron halogenases.

Identification and Spectroscopic Characterization of Nonheme Iron(III) Hypochlorite Intermediates**

PubMed Central

Draksharapu, Apparao; Angelone, Davide; Quesne, Matthew G; Padamati, Sandeep K; Gómez, Laura; Hage, Ronald; Costas, Miquel; Browne, Wesley R; de Visser, Sam P

2015-01-01

FeIII–hypohalite complexes have been implicated in a wide range of important enzyme-catalyzed halogenation reactions including the biosynthesis of natural products and antibiotics and post-translational modification of proteins. The absence of spectroscopic data on such species precludes their identification. Herein, we report the generation and spectroscopic characterization of nonheme FeIII–hypohalite intermediates of possible relevance to iron halogenases. We show that FeIII-OCl polypyridylamine complexes can be sufficiently stable at room temperature to be characterized by UV/Vis absorption, resonance Raman and EPR spectroscopies, and cryo-ESIMS. DFT methods rationalize the pathways to the formation of the FeIII-OCl, and ultimately FeIV=O, species and provide indirect evidence for a short-lived FeII-OCl intermediate. The species observed and the pathways involved offer insight into and, importantly, a spectroscopic database for the investigation of iron halogenases. PMID:25663379

Spectroscopic observation of Lyα emitters at z ∼ 7.7 and implications on re-ionization

DOE Office of Scientific and Technical Information (OSTI.GOV)

Faisst, A. L.; Carollo, C. M.; Capak, P.

2014-06-10

We present spectroscopic follow-up observations on two bright Lyα emitter (LAE) candidates originally found by Krug et al. at a redshift of z ∼ 7.7 using the Multi-Object Spectrometer for Infra-Red Exploration at Keck. We rule out any line emission at the >5σ level for both objects, putting on solid ground a previous null result for one of the objects. The limits inferred from the non-detections rule out the previous claim of no or even reversed evolution between 5.7 < z < 7.7 in the Lyα luminosity function (LF) and suggest a drop in the Lyα LF consistent with thatmore » seen in Lyman break galaxy (LBG) samples. We model the redshift evolution of the LAE LF using the LBG UV-continuum LF and the observed rest-frame equivalent width distribution. From the comparison of our empirical model with the observed LAE distribution, we estimate lower limits of the neutral hydrogen fraction to be 50%-70% at z ∼ 7.7. Together with this, we find a strong evolution in the Lyα optical depth characterized by (1 + z){sup 2.2} {sup ±} {sup 0.5} beyond z = 6, indicative of a strong evolution of the intergalactic medium. Finally, we extrapolate the LAE LF to z ∼ 9 using our model and show that it is unlikely that large area surveys, like UltraVISTA or Euclid, pick up LAEs at this redshift assuming the current depths and area.« less

Creative Entextualizations of Discourses about Race in Multi-Sited Discursive Practices in the Brazilian "Periphery"

ERIC Educational Resources Information Center

Guimarães, Thayse Figueira; Moita-Lopes, Luiz Paulo

2017-01-01

This paper focuses on Luan's race performances both on the web and in classroom interaction. Luan is a black young man, who identifies himself as gay. The study is part of a multi-sited ethnographic piece of research on a group of high-school students in the state sector, in the "periphery" of a town on the Rio de Janeiro State north…

SPIDERS: the spectroscopic follow-up of X-ray selected clusters of galaxies in SDSS-IV

NASA Astrophysics Data System (ADS)

Clerc, N.; Merloni, A.; Zhang, Y.-Y.; Finoguenov, A.; Dwelly, T.; Nandra, K.; Collins, C.; Dawson, K.; Kneib, J.-P.; Rozo, E.; Rykoff, E.; Sadibekova, T.; Brownstein, J.; Lin, Y.-T.; Ridl, J.; Salvato, M.; Schwope, A.; Steinmetz, M.; Seo, H.-J.; Tinker, J.

2016-12-01

SPIDERS (The SPectroscopic IDentification of eROSITA Sources) is a programme dedicated to the homogeneous and complete spectroscopic follow-up of X-ray active galactic nuclei and galaxy clusters over a large area (˜7500 deg2) of the extragalactic sky. SPIDERS is part of the Sloan Digital Sky Survey (SDSS)-IV project, together with the Extended Baryon Oscillation Spectroscopic Survey and the Time-Domain Spectroscopic Survey. This paper describes the largest project within SPIDERS before the launch of eROSITA: an optical spectroscopic survey of X-ray-selected, massive (˜1014-1015 M⊙) galaxy clusters discovered in ROSAT and XMM-Newton imaging. The immediate aim is to determine precise (Δz ˜ 0.001) redshifts for 4000-5000 of these systems out to z ˜ 0.6. The scientific goal of the program is precision cosmology, using clusters as probes of large-scale structure in the expanding Universe. We present the cluster samples, target selection algorithms and observation strategies. We demonstrate the efficiency of selecting targets using a combination of SDSS imaging data, a robust red-sequence finder and a dedicated prioritization scheme. We describe a set of algorithms and work-flow developed to collate spectra and assign cluster membership, and to deliver catalogues of spectroscopically confirmed clusters. We discuss the relevance of line-of-sight velocity dispersion estimators for the richer systems. We illustrate our techniques by constructing a catalogue of 230 spectroscopically validated clusters (0.031 < z < 0.658), found in pilot observations. We discuss two potential science applications of the SPIDERS sample: the study of the X-ray luminosity-velocity dispersion (LX-σ) relation and the building of stacked phase-space diagrams.

Multisite adsorption of cadmium on goethite

DOE Office of Scientific and Technical Information (OSTI.GOV)

Venema, P.; Hiemstra, T.; Riemsdijk, W.H. van

1996-11-10

Recently a new general ion adsorption model has been developed for ion binding to mineral surfaces (Hiemstra and van Riemsdijk, 1996). The model uses the Pauling concept of charge distribution (CD) and is an extension of the multi-site complexation (MUSIC) approach. In the CD-MUSIC model the charge of an adsorbing ion that forms an inner sphere complex is distributed over its ligands, which are present in two different electrostatic planes. In this paper the authors have applied the CD-MUSIC model to the adsorption of metal cations, using an extended data set for cadmium adsorbing on goethite. The adsorption of cadmiummore » and the cadmium-proton exchange ratio were measured as function of metal ion concentration, pH, and ionic strength. The data could be described well, taking into account the surface heterogeneity resulting from the presence of two different crystal planes (the dominant 110 face and the minor 021 face). The surface species used in the model are consistent with recent EXAFS data. In accordance with the EXAFS results, high-affinity complexes at the 021 face were used in the model.« less

SPT-GMOS: A GEMINI/GMOS-SOUTH SPECTROSCOPIC SURVEY OF GALAXY CLUSTERS IN THE SPT-SZ SURVEY

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bayliss, M. B.; Ruel, J.; Stubbs, C. W.

We present the results of SPT-GMOS, a spectroscopic survey with the Gemini Multi-Object Spectrograph (GMOS) on Gemini South. The targets of SPT-GMOS are galaxy clusters identified in the SPT-SZ survey, a millimeter-wave survey of 2500 deg{sup 2} of the southern sky using the South Pole Telescope (SPT). Multi-object spectroscopic observations of 62 SPT-selected galaxy clusters were performed between 2011 January and 2015 December, yielding spectra with radial velocity measurements for 2595 sources. We identify 2243 of these sources as galaxies, and 352 as stars. Of the galaxies, we identify 1579 as members of SPT-SZ galaxy clusters. The primary goal ofmore » these observations was to obtain spectra of cluster member galaxies to estimate cluster redshifts and velocity dispersions. We describe the full spectroscopic data set and resulting data products, including galaxy redshifts, cluster redshifts, and velocity dispersions, and measurements of several well-known spectral indices for each galaxy: the equivalent width, W , of [O ii] λλ 3727, 3729 and H- δ , and the 4000 Å break strength, D4000. We use the spectral indices to classify galaxies by spectral type (i.e., passive, post-starburst, star-forming), and we match the spectra against photometric catalogs to characterize spectroscopically observed cluster members as a function of brightness (relative to m {sup ⋆}). Finally, we report several new measurements of redshifts for ten bright, strongly lensed background galaxies in the cores of eight galaxy clusters. Combining the SPT-GMOS data set with previous spectroscopic follow-up of SPT-SZ galaxy clusters results in spectroscopic measurements for >100 clusters, or ∼20% of the full SPT-SZ sample.« less

SPT-GMOS: A Gemini/GMOS-South Spectroscopic survey of galaxy clusters in the SPT-SZ survey

DOE PAGES

Bayliss, M. B.; Ruel, J.; Stubbs, C. W.; ...

2016-11-01

Here, we present the results of SPT-GMOS, a spectroscopic survey with the Gemini Multi-Object Spectrograph (GMOS) on Gemini South. The targets of SPT-GMOS are galaxy clusters identified in the SPT-SZ survey, a millimeter-wave survey of 2500 deg 2 of the southern sky using the South Pole Telescope (SPT). Multi-object spectroscopic observations of 62 SPT-selected galaxy clusters were performed between 2011 January and 2015 December, yielding spectra with radial velocity measurements for 2595 sources. We identify 2243 of these sources as galaxies, and 352 as stars. Of the galaxies, we identify 1579 as members of SPT-SZ galaxy clusters. The primary goalmore » of these observations was to obtain spectra of cluster member galaxies to estimate cluster redshifts and velocity dispersions. We describe the full spectroscopic data set and resulting data products, including galaxy redshifts, cluster redshifts, and velocity dispersions, and measurements of several well-known spectral indices for each galaxy: the equivalent width, W, of [O II] λλ3727, 3729 and H-δ, and the 4000 Å break strength, D4000. We use the spectral indices to classify galaxies by spectral type (i.e., passive, post-starburst, star-forming), and we match the spectra against photometric catalogs to characterize spectroscopically observed cluster members as a function of brightness (relative to m*). Lastly, we report several new measurements of redshifts for ten bright, strongly lensed background galaxies in the cores of eight galaxy clusters. Combining the SPT-GMOS data set with previous spectroscopic follow-up of SPT-SZ galaxy clusters results in spectroscopic measurements for >100 clusters, or ~20% of the full SPT-SZ sample.« less

SPT-GMOS: A Gemini/GMOS-South Spectroscopic survey of galaxy clusters in the SPT-SZ survey

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bayliss, M. B.; Ruel, J.; Stubbs, C. W.

Here, we present the results of SPT-GMOS, a spectroscopic survey with the Gemini Multi-Object Spectrograph (GMOS) on Gemini South. The targets of SPT-GMOS are galaxy clusters identified in the SPT-SZ survey, a millimeter-wave survey of 2500 deg 2 of the southern sky using the South Pole Telescope (SPT). Multi-object spectroscopic observations of 62 SPT-selected galaxy clusters were performed between 2011 January and 2015 December, yielding spectra with radial velocity measurements for 2595 sources. We identify 2243 of these sources as galaxies, and 352 as stars. Of the galaxies, we identify 1579 as members of SPT-SZ galaxy clusters. The primary goalmore » of these observations was to obtain spectra of cluster member galaxies to estimate cluster redshifts and velocity dispersions. We describe the full spectroscopic data set and resulting data products, including galaxy redshifts, cluster redshifts, and velocity dispersions, and measurements of several well-known spectral indices for each galaxy: the equivalent width, W, of [O II] λλ3727, 3729 and H-δ, and the 4000 Å break strength, D4000. We use the spectral indices to classify galaxies by spectral type (i.e., passive, post-starburst, star-forming), and we match the spectra against photometric catalogs to characterize spectroscopically observed cluster members as a function of brightness (relative to m*). Lastly, we report several new measurements of redshifts for ten bright, strongly lensed background galaxies in the cores of eight galaxy clusters. Combining the SPT-GMOS data set with previous spectroscopic follow-up of SPT-SZ galaxy clusters results in spectroscopic measurements for >100 clusters, or ~20% of the full SPT-SZ sample.« less

SPT-GMOS: A Gemini/GMOS-South Spectroscopic Survey of Galaxy Clusters in the SPT-SZ Survey

NASA Astrophysics Data System (ADS)

Bayliss, M. B.; Ruel, J.; Stubbs, C. W.; Allen, S. W.; Applegate, D. E.; Ashby, M. L. N.; Bautz, M.; Benson, B. A.; Bleem, L. E.; Bocquet, S.; Brodwin, M.; Capasso, R.; Carlstrom, J. E.; Chang, C. L.; Chiu, I.; Cho, H.-M.; Clocchiatti, A.; Crawford, T. M.; Crites, A. T.; de Haan, T.; Desai, S.; Dietrich, J. P.; Dobbs, M. A.; Doucouliagos, A. N.; Foley, R. J.; Forman, W. R.; Garmire, G. P.; George, E. M.; Gladders, M. D.; Gonzalez, A. H.; Gupta, N.; Halverson, N. W.; Hlavacek-Larrondo, J.; Hoekstra, H.; Holder, G. P.; Holzapfel, W. L.; Hou, Z.; Hrubes, J. D.; Huang, N.; Jones, C.; Keisler, R.; Knox, L.; Lee, A. T.; Leitch, E. M.; von der Linden, A.; Luong-Van, D.; Mantz, A.; Marrone, D. P.; McDonald, M.; McMahon, J. J.; Meyer, S. S.; Mocanu, L. M.; Mohr, J. J.; Murray, S. S.; Padin, S.; Pryke, C.; Rapetti, D.; Reichardt, C. L.; Rest, A.; Ruhl, J. E.; Saliwanchik, B. R.; Saro, A.; Sayre, J. T.; Schaffer, K. K.; Schrabback, T.; Shirokoff, E.; Song, J.; Spieler, H. G.; Stalder, B.; Stanford, S. A.; Staniszewski, Z.; Stark, A. A.; Story, K. T.; Vanderlinde, K.; Vieira, J. D.; Vikhlinin, A.; Williamson, R.; Zenteno, A.

2016-11-01

We present the results of SPT-GMOS, a spectroscopic survey with the Gemini Multi-Object Spectrograph (GMOS) on Gemini South. The targets of SPT-GMOS are galaxy clusters identified in the SPT-SZ survey, a millimeter-wave survey of 2500 deg2 of the southern sky using the South Pole Telescope (SPT). Multi-object spectroscopic observations of 62 SPT-selected galaxy clusters were performed between 2011 January and 2015 December, yielding spectra with radial velocity measurements for 2595 sources. We identify 2243 of these sources as galaxies, and 352 as stars. Of the galaxies, we identify 1579 as members of SPT-SZ galaxy clusters. The primary goal of these observations was to obtain spectra of cluster member galaxies to estimate cluster redshifts and velocity dispersions. We describe the full spectroscopic data set and resulting data products, including galaxy redshifts, cluster redshifts, and velocity dispersions, and measurements of several well-known spectral indices for each galaxy: the equivalent width, W, of [O II] λλ3727, 3729 and H-δ, and the 4000 Å break strength, D4000. We use the spectral indices to classify galaxies by spectral type (i.e., passive, post-starburst, star-forming), and we match the spectra against photometric catalogs to characterize spectroscopically observed cluster members as a function of brightness (relative to m⋆). Finally, we report several new measurements of redshifts for ten bright, strongly lensed background galaxies in the cores of eight galaxy clusters. Combining the SPT-GMOS data set with previous spectroscopic follow-up of SPT-SZ galaxy clusters results in spectroscopic measurements for >100 clusters, or ∼20% of the full SPT-SZ sample.

Awareness of Diagnosis and Knowledge of HPV in Women Patients: Data from a Multi-Site Study

ERIC Educational Resources Information Center

McCree, Donna Hubbard; Daley, Ellen M.; Gorbach, Pamina; Hamm, Robert M.; Sharpe, Patricia A.; Brandt, Heather M.; McFarlane, Mary; Kerndt, Peter; McDermott, Robert J.; Perrin, Karen M.; St. Lawrence, Janet S.

2010-01-01

Background: Persistent infection with high-risk types of human papillomavirus (HPV) is associated with cervical and other anogenital cancers. Purpose: This paper reports results of awareness of an HPV diagnosis and HPV knowledge from a multi-site study of HPV knowledge, attitudes and behavior, and the impact of an HPV diagnosis on women and their…

A multisite view of psychosocial risks in patients presenting for bariatric surgery.

PubMed

Rofey, Dana L; Zeller, Meg H; Brode, Cassie; Reiter-Purtill, Jennifer; Mikhail, Carmen; Washington, Gia; Baughcum, Amy E; Peugh, James; Austin, Heather; Jenkins, Todd M; Courcoulas, Anita P

2015-06-01

The psychosocial health of adolescents with severe obesity (BMI ≥ 120% for age and gender) has only recently been the focus of empirical work. This multisite study-an ancillary to a prospective longitudinal observational study documenting health in adolescents having weight loss surgery (WLS)-presents preoperative/baseline data from 141 WLS adolescents and 83 nonsurgical comparisons (NSComps). Self-report data from adolescent and caregiver dyads characterize adolescent psychopathology and potential correlates. One in three adolescents reported internalizing symptoms, and one in five endorsed externalizing symptoms in the clinical range. Generalized linear model analysis demonstrated that increased risk of psychopathology for adolescents with severe obesity was associated with family dysfunction, eating pathology, family composition, and seeking behavioral intervention (versus WLS), whereas better quality of life (QOL) was associated with lower psychopathology. While psychopathology rates are comparable to national samples, there is a subgroup of youth who present for behavioral weight loss services and are at greater risk for psychopathology relative to national adolescent base rates. Adolescents who achieve candidacy for WLS may be a highly selective population of youth with severe obesity and may have lower base rates of psychopathology compared to NSComps. © 2015 The Obesity Society.

Spectroscopic Binaries: Towards the 100-Year Time Domain

NASA Astrophysics Data System (ADS)

Griffin, R. F.

2012-04-01

Good measurements of visual binary stars (position angle and angular separation) have been made for nearly 200 years. Radial-velocity observers have exhibited less patience; when the orbital periods of late-type stars in the catalogue published in 1978 are sorted into bins half a logarithmic unit wide, the modal bin is the one with periods between 3 and 10 days. The same treatment of the writer's orbits shows the modal bin to be the one between 1000 and 3000 days. Of course the spectroscopists cannot quickly catch up the 200 years that the visual observers have been going, but many spectroscopic orbits with periods of decades, and a few of the order of a century, have been published. Technical developments have also been made in `visual' orbit determination, and orbits with periods of only a few days have been determined for certain `visual' binaries. In principle, therefore, the time domains of visual and spectroscopic binaries now largely overlap. Overlap is essential, as it is only by combining both techniques that orbits can be determined in three dimensions, as is necessary for the important objective of determining stellar masses accurately. Nevertheless the actual overlap-objects with accurate measurements by both techniques-remains disappointingly small. There have, however, been unforeseen benefits from the observation of spectroscopic binaries that have unconventionally long orbital periods, not a few of which have proved to be interesting and significant objects in their own right. It has also been shown that binary membership is more common than was once thought (orbits have even been determined for some of the IAU standard radial-velocity stars!); a recent study of the radial velocities of K giants that had been monitored for 45 years found a binary incidence of 30%, whereas a figure of 13.7% was given as recently as 2005 for a similar group.

Spectroscopic Classification of SN 2018gv with Keck I/LRIS

NASA Astrophysics Data System (ADS)

Siebert, M. R.; Dimitriadis, G.; Foley, R. J.

2018-01-01

We obtained spectroscopic observations of SN 2018gv with the LRIS spectrograph on the 10-m Keck I telescope on 2018 Jan 16 UT. The spectrum indicates that SN 2018gv is a very young, normal Type Ia supernova.

High-Accuracy Quartic Force Field Calculations for the Spectroscopic Constants and Vibrational Frequencies of 1(exp 1)A' l-C3H(-): A Possible Link to Lines Observed in the Horsehead Nebula PDR

NASA Technical Reports Server (NTRS)

Fortenberry, Ryan C.; Huang, Xinchuan; Crawford, T. Daniel; Lee, Timothy J.

2013-01-01

It has been shown that rotational lines observed in the Horsehead nebula photon-dominated-region (PDR) are probably not caused by l-C3H+, as was originally suggested. In the search for viable alternative candidate carriers, quartic force fields are employed here to provide highly accurate rotational constants, as well as fundamental vibrational frequencies, for another candidate carrier: 1 (sup 1)A' C3H(-). The ab initio computed spectroscopic constants provided in this work are, compared to those necessary to define the observed lines, as accurate as the computed spectroscopic constants for many of the known interstellar anions. Additionally, the computed D-eff for C3H(-) is three times closer to the D deduced from the observed Horsehead nebula lines relative to l-C3H(+). As a result, 1 (sup 1)A' C3H(-). is a more viable candidate for these observed rotational transitions and would be the seventh confirmed interstellar anion detected within the past decade and the first C(sub n)H(-) molecular anion with an odd n.

Spectroscopic analysis and control

DOEpatents

Tate; , James D.; Reed, Christopher J.; Domke, Christopher H.; Le, Linh; Seasholtz, Mary Beth; Weber, Andy; Lipp, Charles

2017-04-18

Apparatus for spectroscopic analysis which includes a tunable diode laser spectrometer having a digital output signal and a digital computer for receiving the digital output signal from the spectrometer, the digital computer programmed to process the digital output signal using a multivariate regression algorithm. In addition, a spectroscopic method of analysis using such apparatus. Finally, a method for controlling an ethylene cracker hydrogenator.

The LAMOST Complete Spectroscopic Survey of Pointing Area (LaCoSSPAr) in the Southern Galactic Cap. I. The Spectroscopic Redshift Catalog

NASA Astrophysics Data System (ADS)

Yang, Ming; Wu, Hong; Yang, Fan; Lam, Man I.; Cao, Tian-Wen; Wu, Chao-Jian; Zhao, Pin-Song; Zhang, Tian-Meng; Zhou, Zhi-Min; Wu, Xue-Bing; Zhang, Yan-Xia; Shao, Zheng-Yi; Jing, Yi-Peng; Shen, Shi-Yin; Zhu, Yi-Nan; Du, Wei; Lei, Feng-Jie; He, Min; Jin, Jun-Jie; Shi, Jian-Rong; Zhang, Wei; Wang, Jian-Ling; Wu, Yu-Zhong; Zhang, Hao-Tong; Luo, A.-Li; Yuan, Hai-Long; Bai, Zhong-Rui; Kong, Xu; Gu, Qiu-Sheng; Zhou, Xu; Ma, Jun; Hu, Zou; Nie, Jun-Dan; Wang, Jia-Li; Zhang, Yong; Hou, Yong-Hui; Zhao, Yong-Heng

2018-01-01

We present a spectroscopic redshift catalog from the LAMOST Complete Spectroscopic Survey of Pointing Area (LaCoSSPAr) in the Southern Galactic Cap (SGC), which is designed to observe all sources (Galactic and extragalactic) by using repeating observations with a limiting magnitude of r=18.1 {mag} in two 20 {\\deg }2 fields. The project is mainly focusing on the completeness of LAMOST ExtraGAlactic Surveys (LEGAS) in the SGC, the deficiencies of source selection methods, and the basic performance parameters of the LAMOST telescope. In both fields, more than 95% of galaxies have been observed. A post-processing has been applied to the LAMOST 1D spectrum to remove the majority of remaining sky background residuals. More than 10,000 spectra have been visually inspected to measure the redshift by using combinations of different emission/absorption features with an uncertainty of {σ }z/(1+z)< 0.001. In total, 1528 redshifts (623 absorption and 905 emission line galaxies) in Field A and 1570 redshifts (569 absorption and 1001 emission line galaxies) in Field B have been measured. The results show that it is possible to derive redshift from low S/N galaxies with our post-processing and visual inspection. Our analysis also indicates that up to one-fourth of the input targets for a typical extragalactic spectroscopic survey might be unreliable. The multi-wavelength data analysis shows that the majority of mid-infrared-detected absorption (91.3%) and emission line galaxies (93.3%) can be well separated by an empirical criterion of W2-W3=2.4. Meanwhile, a fainter sequence paralleled to the main population of galaxies has been witnessed both in M r /W2-W3 and M */W2-W3 diagrams, which could be the population of luminous dwarf galaxies but contaminated by the edge-on/highly inclined galaxies (∼ 30 % ).

A novel environmental chamber for neuronal network multisite recordings.

PubMed

Biffi, E; Regalia, G; Ghezzi, D; De Ceglia, R; Menegon, A; Ferrigno, G; Fiore, G B; Pedrocchi, A

2012-10-01

Environmental stability is a critical issue for neuronal networks in vitro. Hence, the ability to control the physical and chemical environment of cell cultures during electrophysiological measurements is an important requirement in the experimental design. In this work, we describe the development and the experimental verification of a closed chamber for multisite electrophysiology and optical monitoring. The chamber provides stable temperature, pH and humidity and guarantees cell viability comparable to standard incubators. Besides, it integrates the electronics for long-term neuronal activity recording. The system is portable and adaptable for multiple network housings, which allows performing parallel experiments in the same environment. Our results show that this device can be a solution for long-term electrophysiology, for dual network experiments and for coupled optical and electrical measurements. Copyright © 2012 Wiley Periodicals, Inc.

Self-adaptive tensor network states with multi-site correlators

NASA Astrophysics Data System (ADS)

Kovyrshin, Arseny; Reiher, Markus

2017-12-01

We introduce the concept of self-adaptive tensor network states (SATNSs) based on multi-site correlators. The SATNS ansatz gradually extends its variational space incorporating the most important next-order correlators into the ansatz for the wave function. The selection of these correlators is guided by entanglement-entropy measures from quantum information theory. By sequentially introducing variational parameters and adjusting them to the system under study, the SATNS ansatz achieves keeping their number significantly smaller than the total number of full-configuration interaction parameters. The SATNS ansatz is studied for manganocene in its lowest-energy sextet and doublet states; the latter of which is known to be difficult to describe. It is shown that the SATNS parametrization solves the convergence issues found for previous correlator-based tensor network states.

What Works Clearinghouse Quick Review: "Transfer Incentives for High-Performing Teachers: Final Results from a Multisite Experiment"

ERIC Educational Resources Information Center

What Works Clearinghouse, 2014

2014-01-01

"Transfer Incentives for High-Performing Teachers: Final Results from a Multisite Experiment," examined the impact of the Talent Transfer Initiative (TTI) on both student achievement and teacher retention in 10 school districts across seven states. The initiative gave bonuses to high-performing teachers for them to transfer to and stay…

Spectroscopic observation of Gaia17dht and Gaia17diu by NUTS (NOT Un-biased Transient Survey)

NASA Astrophysics Data System (ADS)

Fraser, M.; Dyrbye, S.; Cappella, E.

2017-12-01

The Nordic Optical Telescope (NOT) Unbiased Transient Survey (NUTS; ATel #8992) reports the spectroscopic classification of Gaia17dht/SN2017izz and Gaia17diu/SN2017jdb (in host galaxies SDSS J145121.24+283521.6 and LEDA 2753585 respectively).

Spectroscopic properties of some borate glasses containg uranium

NASA Astrophysics Data System (ADS)

Culea, E.; Milea, I.; Bratu, I.

1993-03-01

Spectroscopic properties of some borate glasses containing 1-5%UO 3 have been studied in the fields of 700-1200 cm -1 and 10,000-30,000 cm -1 Absorption bands specific for U 6+ and U 4+ ions were observed. The increase of the melting time produces the reduction of U 6+ ions to U 4+.

A New Method to Comprehensively Diagnose Shock Waves in the Solar Atmosphere Based on Simultaneous Spectroscopic and Imaging Observations

NASA Astrophysics Data System (ADS)

Ruan, Wenzhi; Yan, Limei; He, Jiansen; Zhang, Lei; Wang, Linghua; Wei, Yong

2018-06-01

Shock waves are believed to play an important role in plasma heating. The shock-like temporal jumps in radiation intensity and Doppler shift have been identified in the solar atmosphere. However, a quantitative diagnosis of the shocks in the solar atmosphere is still lacking, seriously hindering the understanding of shock dissipative heating of the solar atmosphere. Here, we propose a new method to realize the goal of the shock quantitative diagnosis, based on Rankine–Hugoniot equations and taking the advantages of simultaneous imaging and spectroscopic observations from, e.g., IRIS (Interface Region Imaging Spectrograph). Because of this method, the key parameters of shock candidates can be derived, such as the bulk velocity and temperature of the plasma in the upstream and downstream, the propagation speed and direction. The method is applied to the shock candidates observed by IRIS, and the overall characteristics of the shocks are revealed quantitatively for the first time. This method is also tested with the help of forward modeling, i.e., virtual observations of simulated shocks. The parameters obtained from the method are consistent with the parameters of the shock formed in the model and are independent of the viewing direction. Therefore, the method we proposed here is applicable to the quantitative and comprehensive diagnosis of the observed shocks in the solar atmosphere.

SPIDERS: the spectroscopic follow-up of X-ray-selected clusters of galaxies in SDSS-IV

DOE PAGES

Clerc, N.; Merloni, A.; Zhang, Y. -Y.; ...

2016-09-05

SPIDERS (The SPectroscopic IDentification of ERosita Sources) is a programme dedicated to the homogeneous and complete spectroscopic follow-up of X-ray active galactic nuclei and galaxy clusters over a large area (~7500 deg 2) of the extragalactic sky. SPIDERS is part of the Sloan Digital Sky Survey (SDSS)-IV project, together with the Extended Baryon Oscillation Spectroscopic Survey and the Time-Domain Spectroscopic Survey. This study describes the largest project within SPIDERS before the launch of eROSITA: an optical spectroscopic survey of X-ray-selected, massive (~10 14–10 15 M⊙) galaxy clusters discovered in ROSAT and XMM–Newton imaging. The immediate aim is to determine precisemore » (Δz ~ 0.001) redshifts for 4000–5000 of these systems out to z ~ 0.6. The scientific goal of the program is precision cosmology, using clusters as probes of large-scale structure in the expanding Universe. We present the cluster samples, target selection algorithms and observation strategies. We demonstrate the efficiency of selecting targets using a combination of SDSS imaging data, a robust red-sequence finder and a dedicated prioritization scheme. We describe a set of algorithms and work-flow developed to collate spectra and assign cluster membership, and to deliver catalogues of spectroscopically confirmed clusters. We discuss the relevance of line-of-sight velocity dispersion estimators for the richer systems. We illustrate our techniques by constructing a catalogue of 230 spectroscopically validated clusters (0.031 < z < 0.658), found in pilot observations. Finally, we discuss two potential science applications of the SPIDERS sample: the study of the X-ray luminosity-velocity dispersion (LX–σ) relation and the building of stacked phase-space diagrams.« less

Spectroscopic evidence of α-methylbenzyl radical in the gas phase

NASA Astrophysics Data System (ADS)

Lee, Gi Woo; Ahn, Hyeon Geun; Kim, Tae Kyu; Lee, Sang Kuk

2008-11-01

We report the observation of the spectroscopic evidence of the α-methylbenzyl radical in a corona excited supersonic expansion using a pinhole-type glass nozzle for the first time. The precursors, toluene, ethylbenzene, and isopropylbenzene, seeded in a large amount of inert carrier gas helium, were electrically discharged to produce benzyl-type radicals as a result of the breaking off of a C-H or a C-C bond from the alkyl chain. The vibronic emission spectra, obtained in the visible region from the precursors, were compared to identify the species generated in the corona discharge of the precursors, from which we found the spectroscopic evidence of the α-methylbenzyl radical.

Spectroscopic Study of the Early-Type Binary HX Vel A

NASA Astrophysics Data System (ADS)

Özkardeş, Burcu; Sürgit, Derya; Erdem, Ahmet; Budding, Edwin; Soydugan, Faruk; Demircan, Osman

2012-04-01

This paper presents high resolution spectroscopy of the HX Vel (IDS 08390-4744 AB) multiple system. New spectroscopic observations of the system were made at Mt. John University Observatory in 2007 and 2008. Radial velocities of both components of HX Vel A were measured using gaussian fitting. The spectroscopic mass ratio of the close binary was determined as 0.599+/-0.052, according to a Keplerian orbital solution. The resulting orbital elements are a1sini=0.0098+/-0.0003 AU, a2sini=0.0164+/-0.0003 AU, M1sin3i=1.19+/-0.07 M⊙ and M2sin3i=0.71+/-0.04 M⊙.

Spectroscopic observation of ASASSN-17nb and CSS170922:172546+342249 by NUTS (NOT Un-biased Transient Survey)

NASA Astrophysics Data System (ADS)

Harmanen, J.; Mattila, S.; Kuncarayakti, H.; Reynolds, T.; Somero, A.; Kangas, T.; Lundqvist, P.; Taddia, F.; Ergon, M.; Dong, S.; Pastorello, A.; Pursimo, T.; NUTS Collaboration

2017-10-01

The Nordic Optical Telescope (NOT) Unbiased Transient Survey (NUTS; ATel #8992) reports the spectroscopic classification of ASASSN-17nb in MCG+06-17-007 and CSS170922:172546+342249 in an unknown host galaxy.

The SDSS-IV extended Baryon Oscillation Spectroscopic Survey: Overview and early data

DOE PAGES

Kyle S. Dawson

2016-02-04

In a six-year program started in 2014 July, the Extended Baryon Oscillation Spectroscopic Survey (eBOSS) will conduct novel cosmological observations using the BOSS spectrograph at Apache Point Observatory. These observations will be conducted simultaneously with the Time Domain Spectroscopic Survey (TDSS) designed for variability studies and the Spectroscopic Identification of eROSITA Sources (SPIDERS) program designed for studies of X-ray sources. In particular, eBOSS will measure with percent-level precision the distance-redshift relation with baryon acoustic oscillations (BAO) in the clustering of matter. eBOSS will use four different tracers of the underlying matter density field to vastly expand the volume covered bymore » BOSS and map the large-scale-structures over the relatively unconstrained redshift range 0.6 < z < 2.2. Using more than 250,000 new, spectroscopically confirmed luminous red galaxies at a median redshift z = 0.72, we project that eBOSS will yield measurements of the angular diameter distance d A(z) to an accuracy of 1.2% and measurements of H(z) to 2.1% when combined with the z > 0.6 sample of BOSS galaxies. With ~195,000 new emission line galaxy redshifts, we expect BAO measurements of d A(z) to an accuracy of 3.1% and H(z) to 4.7% at an effective redshift of z = 0.87. A sample of more than 500,000 spectroscopically confirmed quasars will provide the first BAO distance measurements over the redshift range 0.9 < z < 2.2, with expected precision of 2.8% and 4.2% on d A(z) and H(z), respectively. Finally, with 60,000 new quasars and re-observation of 60,000 BOSS quasars, we will obtain new Lyα forest measurements at redshifts z > 2.1; these new data will enhance the precision of d A(z) and H(z) at z > 2.1 by a factor of 1.44 relative to BOSS. Furthermore, eBOSS will provide improved tests of General Relativity on cosmological scales through redshift-space distortion measurements, improved tests for non-Gaussianity in the primordial density

The SDSS-IV extended Baryon Oscillation Spectroscopic Survey: Overview and early data

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kyle S. Dawson

In a six-year program started in 2014 July, the Extended Baryon Oscillation Spectroscopic Survey (eBOSS) will conduct novel cosmological observations using the BOSS spectrograph at Apache Point Observatory. These observations will be conducted simultaneously with the Time Domain Spectroscopic Survey (TDSS) designed for variability studies and the Spectroscopic Identification of eROSITA Sources (SPIDERS) program designed for studies of X-ray sources. In particular, eBOSS will measure with percent-level precision the distance-redshift relation with baryon acoustic oscillations (BAO) in the clustering of matter. eBOSS will use four different tracers of the underlying matter density field to vastly expand the volume covered bymore » BOSS and map the large-scale-structures over the relatively unconstrained redshift range 0.6 < z < 2.2. Using more than 250,000 new, spectroscopically confirmed luminous red galaxies at a median redshift z = 0.72, we project that eBOSS will yield measurements of the angular diameter distance d A(z) to an accuracy of 1.2% and measurements of H(z) to 2.1% when combined with the z > 0.6 sample of BOSS galaxies. With ~195,000 new emission line galaxy redshifts, we expect BAO measurements of d A(z) to an accuracy of 3.1% and H(z) to 4.7% at an effective redshift of z = 0.87. A sample of more than 500,000 spectroscopically confirmed quasars will provide the first BAO distance measurements over the redshift range 0.9 < z < 2.2, with expected precision of 2.8% and 4.2% on d A(z) and H(z), respectively. Finally, with 60,000 new quasars and re-observation of 60,000 BOSS quasars, we will obtain new Lyα forest measurements at redshifts z > 2.1; these new data will enhance the precision of d A(z) and H(z) at z > 2.1 by a factor of 1.44 relative to BOSS. Furthermore, eBOSS will provide improved tests of General Relativity on cosmological scales through redshift-space distortion measurements, improved tests for non-Gaussianity in the primordial density

Intra-operative multi-site stimulation: Expanding methodology for cortical brain mapping of language functions.

PubMed

Gonen, Tal; Gazit, Tomer; Korn, Akiva; Kirschner, Adi; Perry, Daniella; Hendler, Talma; Ram, Zvi

2017-01-01

Direct cortical stimulation (DCS) is considered the gold-standard for functional cortical mapping during awake surgery for brain tumor resection. DCS is performed by stimulating one local cortical area at a time. We present a feasibility study using an intra-operative technique aimed at improving our ability to map brain functions which rely on activity in distributed cortical regions. Following standard DCS, Multi-Site Stimulation (MSS) was performed in 15 patients by applying simultaneous cortical stimulations at multiple locations. Language functioning was chosen as a case-cognitive domain due to its relatively well-known cortical organization. MSS, performed at sites that did not produce disruption when applied in a single stimulation point, revealed additional language dysfunction in 73% of the patients. Functional regions identified by this technique were presumed to be significant to language circuitry and were spared during surgery. No new neurological deficits were observed in any of the patients following surgery. Though the neuro-electrical effects of MSS need further investigation, this feasibility study may provide a first step towards sophistication of intra-operative cortical mapping.

Intra-operative multi-site stimulation: Expanding methodology for cortical brain mapping of language functions

PubMed Central

Korn, Akiva; Kirschner, Adi; Perry, Daniella; Hendler, Talma; Ram, Zvi

2017-01-01

Direct cortical stimulation (DCS) is considered the gold-standard for functional cortical mapping during awake surgery for brain tumor resection. DCS is performed by stimulating one local cortical area at a time. We present a feasibility study using an intra-operative technique aimed at improving our ability to map brain functions which rely on activity in distributed cortical regions. Following standard DCS, Multi-Site Stimulation (MSS) was performed in 15 patients by applying simultaneous cortical stimulations at multiple locations. Language functioning was chosen as a case-cognitive domain due to its relatively well-known cortical organization. MSS, performed at sites that did not produce disruption when applied in a single stimulation point, revealed additional language dysfunction in 73% of the patients. Functional regions identified by this technique were presumed to be significant to language circuitry and were spared during surgery. No new neurological deficits were observed in any of the patients following surgery. Though the neuro-electrical effects of MSS need further investigation, this feasibility study may provide a first step towards sophistication of intra-operative cortical mapping. PMID:28700619

Spectroscopic and Interferometric Measurements of Nine K Giant Stars

NASA Astrophysics Data System (ADS)

Baines, Ellyn K.; Döllinger, Michaela P.; Guenther, Eike W.; Hatzes, Artie P.; Hrudkovu, Marie; van Belle, Gerard T.

2016-09-01

We present spectroscopic and interferometric measurements for a sample of nine K giant stars. These targets are of particular interest because they are slated for stellar oscillation observations. Our improved parameters will directly translate into reduced errors in the final masses for these stars when interferometric radii and asteroseismic densities are combined. Here, we determine each star’s limb-darkened angular diameter, physical radius, luminosity, bolometric flux, effective temperature, surface gravity, metallicity, and mass. When we compare our interferometric and spectroscopic results, we find no systematic offsets in the diameters and the values generally agree within the errors. Our interferometric temperatures for seven of the nine stars are hotter than those determined from spectroscopy with an average difference of about 380 K.

Spectroscopic Instrumentation in Undergraduate Astronomy Laboratories

NASA Astrophysics Data System (ADS)

Ludovici, Dominic; Mutel, Robert Lucien; Lang, Cornelia C.

2017-01-01

We have designed and built two spectrographs for use in undergraduate astronomy laboratories at the University of Iowa. The first, a low cost (appx. $500) low resolution (R ~ 150 - 300) grating-prism (grism) spectrometer consists of five optical elements and is easily modified to other telescope optics. The grism spectrometer is designed to be used in a modified filter wheel. This type of spectrometer allows students to undertake projects requiring sensitive spectral measurements, such as determining the redshifts of quasars. The second instrument is a high resolution (R ~ 8000), moderate cost (appx. $5000) fiber fed echelle spectrometer. The echelle spectrometer will allow students to conduct Doppler measurements such as those used to study spectroscopic binaries. Both systems are designed to be used with robotic telescope systems. The availability of 3D printing enables both of these spectrographs to be constructed in hands-on instrumentation courses where students build and commission their own instruments. Additionally, these instruments enable introductory majors and non-majors laboratory students to gain experience conducting their own spectroscopic observations.

The effect of simulation courseware on critical thinking in undergraduate nursing students: multi-site pre-post study.

PubMed

Shin, Hyunsook; Ma, Hyunhee; Park, Jiyoung; Ji, Eun Sun; Kim, Dong Hee

2015-04-01

The use of simulations has been considered as opportunities for students to enhance their critical thinking (CT), but previous studies were limited because they did not provide in-depth information on the working dynamics of simulation or on the effects of the number of simulation exposures on CT. This study examined the effect of an integrated pediatric nursing simulation used in a nursing practicum on students' CT abilities and identified the effects of differing numbers of simulation exposures on CT in a multi-site environment. The study used a multi-site, pre-test, post-test design. A total of 237 nursing students at three universities enrolled in a pediatric practicum participated in this study from February to December 2013. All three schools used the same simulation courseware, including the same simulation scenarios, evaluation tools, and simulation equipment. The courseware incorporated high-fidelity simulators and standardized patients. Students at school A completed one simulation session, whereas students at schools B and C completed two and three simulation sessions, respectively. Yoon's Critical Thinking Disposition tool (2008) was used to measure students' CT abilities. The gains in students' CT scores varied according to their numbers of exposures to the simulation courseware. With a single exposure, there were no statistically significant gains in CT, whereas three exposures to the courseware produced significant gains in CT. In seven subcategories of critical thinking, three exposures to the simulation courseware produced CT gains in the prudence and intellectual eagerness subcategories, and the overall simulation experience produced CT gains in the prudence, systematicity, healthy skepticism, and intellectual eagerness subcategories. Simulation courseware may produce positive learning outcomes for prudence in nursing education. In addition, the findings from the multi-site comparative study may contribute to greater understanding of how patient

Collaborative Imaginaries and Multi-Sited Ethnography: Space-Time Dimensions of Engagement in an Afterschool Science Programme for Girls

ERIC Educational Resources Information Center

Rahm, Jrene

2012-01-01

Temporal and spatial configurations that constitute learning and identity work across practices have been little explored in studies of science literacy development. Grounded in multi-sited ethnography, this paper explores diverse girls' engagement with and identity work in science locally, inside a newsletter activity in an afterschool programme…

Replication and Comparison of the Newly Proposed ADOS-2, Module 4 Algorithm in ASD without ID: A Multi-site Study

PubMed Central

Pugliese, Cara E.; Kenworthy, Lauren; Bal, Vanessa Hus; Wallace, Gregory L; Yerys, Benjamin E; Maddox, Brenna B.; White, Susan W.; Popal, Haroon; Armour, Anna Chelsea; Miller, Judith; Herrington, John D.; Schultz, Robert T.; Martin, Alex; Anthony, Laura Gutermuth

2015-01-01

Recent updates have been proposed to the Autism Diagnostic Observation Schedule-2 Module 4 diagnostic algorithm. This new algorithm, however, has not yet been validated in an independent sample without intellectual disability (ID). This multi-site study compared the original and revised algorithms in individuals with ASD without ID. The revised algorithm demonstrated increased sensitivity, but lower specificity in the overall sample. Estimates were highest for females, individuals with a verbal IQ below 85 or above 115, and ages 16 and older. Best practice diagnostic procedures should include the Module 4 in conjunction with other assessment tools. Balancing needs for sensitivity and specificity depending on the purpose of assessment (e.g., clinical vs. research) and demographic characteristics mentioned above will enhance its utility. PMID:26385796

Replication and Comparison of the Newly Proposed ADOS-2, Module 4 Algorithm in ASD Without ID: A Multi-site Study.

PubMed

Pugliese, Cara E; Kenworthy, Lauren; Bal, Vanessa Hus; Wallace, Gregory L; Yerys, Benjamin E; Maddox, Brenna B; White, Susan W; Popal, Haroon; Armour, Anna Chelsea; Miller, Judith; Herrington, John D; Schultz, Robert T; Martin, Alex; Anthony, Laura Gutermuth

2015-12-01

Recent updates have been proposed to the Autism Diagnostic Observation Schedule-2 Module 4 diagnostic algorithm. This new algorithm, however, has not yet been validated in an independent sample without intellectual disability (ID). This multi-site study compared the original and revised algorithms in individuals with ASD without ID. The revised algorithm demonstrated increased sensitivity, but lower specificity in the overall sample. Estimates were highest for females, individuals with a verbal IQ below 85 or above 115, and ages 16 and older. Best practice diagnostic procedures should include the Module 4 in conjunction with other assessment tools. Balancing needs for sensitivity and specificity depending on the purpose of assessment (e.g., clinical vs. research) and demographic characteristics mentioned above will enhance its utility.

Analytical recursive method to ascertain multisite entanglement in doped quantum spin ladders

NASA Astrophysics Data System (ADS)

Roy, Sudipto Singha; Dhar, Himadri Shekhar; Rakshit, Debraj; SenDe, Aditi; Sen, Ujjwal

2017-08-01

We formulate an analytical recursive method to generate the wave function of doped short-range resonating valence bond (RVB) states as a tool to efficiently estimate multisite entanglement as well as other physical quantities in doped quantum spin ladders. We prove that doped RVB ladder states are always genuine multipartite entangled. Importantly, our results show that within specific doping concentration and model parameter regimes, the doped RVB state essentially characterizes the trends of genuine multiparty entanglement in the exact ground states of the Hubbard model with large on-site interactions, in the limit that yields the t -J Hamiltonian.

Spectroscopic Survey of Circumstellar Disks in Orion

NASA Astrophysics Data System (ADS)

Contreras, Maria; Hernandez, Jesus; Olguin, Lorenzo; Briceno, Cesar

2013-07-01

As a second stage of a project focused on characterizing candidate stars bearing a circumstellar disk in Orion, we present a spectroscopic follow-up of a set of about 170 bright stars. The present set of stars was selected by their optical (UBVRI) and infrared behavior in different color-color and color-magnitude diagrams. Observations were carried out at the Observatorio Astronomico Nacional located at the Sierra San Pedro Martir in B.C., Mexico and at the Observatorio Guillermo Haro in Cananea, Sonora, Mexico. Low-resolution spectra were obtained for all candidates in the sample. Using the SPTCLASS code, we have obtained spectral types and equivalent widths of the Li I 6707 and Halpha lines for each one of the stars. This project is a cornerstone of a large scale survey aimed to obtain stellar parameters in a homogeneous way using spectroscopic data. This work was partially supported by UNAM-PAPIIT grant IN-109311.

Unveiling the nature of two unidentified EGRET blazar candidates through spectroscopic observations

NASA Astrophysics Data System (ADS)

Nkundabakura, P.; Meintjes, P. J.

2012-11-01

Studies using the Energetic Gamma-Ray Experiment Telescope (EGRET) revealed that blazars [flat-spectrum radio quasars (FSRQs) and BL Lac objects] emit most of their luminosity in the high-energy gamma-ray (E > 100 MeV) range. From the 271 sources observed by EGRET, 131 are still unidentified. A systematic search is conducted to identify possible high-energy gamma-ray blazars among the unidentified EGRET population. Based upon multiwavelength emission properties, 13 extragalactic radio sources were selected in the EGRET error boxes for further investigation. From the above-mentioned sample, results of a multiwavelength follow-up of two EGRET sources, 3EG J0821-5814 and 3EG J0706-3837, are presented. These sources are associated with their radio counterparts PKS J0820-5705 and PMN J0710-3850, respectively. Spectroscopic observations utilizing the SOAR/Goodman spectrograph at the Cerro Tololo Inter-American Observatory in Chile reveal a spectrum of PKS J0820-5705 that corresponds to that of a radio-loud active galactic nucleus (FSRQ) with redshift z = 0.06 ± 0.01, while the visibility of wide and narrow emission lines in the spectrum of PMN J0710-3850 resembles that of a low-ionization nuclear emission-line region (LINER) or type 1 Seyfert galaxy at z = 0.129 ± 0.001. The observed Ca II K&H lines depression ratio at 4000 Å showed a shallow depression of 8.8 ± 2.5 per cent for PKS J0820-5705 and 80 ± 1 per cent for PMN J0710-3850, suggesting the presence of a strong non-thermal optical contribution in PKS J0820-5705, which clearly distinguishes its spectrum from that of a radio galaxy. The weaker optical non-thermal contribution for PMN J0710-3850 is in accordance with that expected of a LINER. For PMN J0710-3850 the line flux ratios [O III] λ5007/Hβ < 3 and [N II] λ6583/Hα > 0.6 which are in agreement with the expected ratios of LINERs. However, the absence of [O II] λ3727 implies an anomalously low [O II]/[O III] < 0.5 ratio for a LINER, and agrees more

Spectroscopic database

NASA Technical Reports Server (NTRS)

Husson, N.; Barbe, A.; Brown, L. R.; Carli, B.; Goldman, A.; Pickett, H. M.; Roche, A. E.; Rothman, L. S.; Smith, M. A. H.

1985-01-01

Several aspects of quantitative atmospheric spectroscopy are considered, using a classification of the molecules according to the gas amounts in the stratosphere and upper troposphere, and reviews of quantitative atmospheric high-resolution spectroscopic measurements and field measurements systems are given. Laboratory spectroscopy and spectral analysis and prediction are presented with a summary of current laboratory spectroscopy capabilities. Spectroscopic data requirements for accurate derivation of atmospheric composition are discussed, where examples are given for space-based remote sensing experiments of the atmosphere: the ATMOS (Atmospheric Trace Molecule) and UARS (Upper Atmosphere Research Satellite) experiment. A review of the basic parameters involved in the data compilations; a summary of information on line parameter compilations already in existence; and a summary of current laboratory spectroscopy studies are used to assess the data base.

Multifunction Imaging and Spectroscopic Instrument

NASA Technical Reports Server (NTRS)

Mouroulis, Pantazis

2004-01-01

A proposed optoelectronic instrument would perform several different spectroscopic and imaging functions that, heretofore, have been performed by separate instruments. The functions would be reflectance, fluorescence, and Raman spectroscopies; variable-color confocal imaging at two different resolutions; and wide-field color imaging. The instrument was conceived for use in examination of minerals on remote planets. It could also be used on Earth to characterize material specimens. The conceptual design of the instrument emphasizes compactness and economy, to be achieved largely through sharing of components among subsystems that perform different imaging and spectrometric functions. The input optics for the various functions would be mounted in a single optical head. With the exception of a targeting lens, the input optics would all be aimed at the same spot on a specimen, thereby both (1) eliminating the need to reposition the specimen to perform different imaging and/or spectroscopic observations and (2) ensuring that data from such observations can be correlated with respect to known positions on the specimen. The figure schematically depicts the principal components and subsystems of the instrument. The targeting lens would collect light into a multimode optical fiber, which would guide the light through a fiber-selection switch to a reflection/ fluorescence spectrometer. The switch would have four positions, enabling selection of spectrometer input from the targeting lens, from either of one or two multimode optical fibers coming from a reflectance/fluorescence- microspectrometer optical head, or from a dark calibration position (no fiber). The switch would be the only moving part within the instrument.

Year One Results from the Multisite Randomized Evaluation of the i3 Scale-Up of Reading Recovery

ERIC Educational Resources Information Center

May, Henry; Gray, Abigail; Sirinides, Philip; Goldsworthy, Heather; Armijo, Michael; Sam, Cecile; Gillespie, Jessica N.; Tognatta, Namrata

2015-01-01

Reading Recovery (RR) is a short-term, one-to-one intervention designed to help the lowest achieving readers in first grade. This article presents first-year results from the multisite randomized controlled trial (RCT) and implementation study under the $55 million Investing in Innovation (i3) Scale-Up Project. For the 2011-2012 school year, the…

Robust multi-site MR data processing: iterative optimization of bias correction, tissue classification, and registration.

PubMed

Young Kim, Eun; Johnson, Hans J

2013-01-01

A robust multi-modal tool, for automated registration, bias correction, and tissue classification, has been implemented for large-scale heterogeneous multi-site longitudinal MR data analysis. This work focused on improving the an iterative optimization framework between bias-correction, registration, and tissue classification inspired from previous work. The primary contributions are robustness improvements from incorporation of following four elements: (1) utilize multi-modal and repeated scans, (2) incorporate high-deformable registration, (3) use extended set of tissue definitions, and (4) use of multi-modal aware intensity-context priors. The benefits of these enhancements were investigated by a series of experiments with both simulated brain data set (BrainWeb) and by applying to highly-heterogeneous data from a 32 site imaging study with quality assessments through the expert visual inspection. The implementation of this tool is tailored for, but not limited to, large-scale data processing with great data variation with a flexible interface. In this paper, we describe enhancements to a joint registration, bias correction, and the tissue classification, that improve the generalizability and robustness for processing multi-modal longitudinal MR scans collected at multi-sites. The tool was evaluated by using both simulated and simulated and human subject MRI images. With these enhancements, the results showed improved robustness for large-scale heterogeneous MRI processing.

Spectroscopic planetary detection

NASA Technical Reports Server (NTRS)

Deming, Drake

1991-01-01

One of the most promising methods for the detection of extra-solar planets is the spectroscopic method, where a small Doppler shift (approx. 10 meter/sec) in the spectrum of the parent star reveals the presence of planetary companions. However, solar type stars may show spurious Doppler shifts due to surface activity. If these effects are periodic, as is the solar activity cycle, then they may masquerade as planetary companions. The goal of this study was to determine whether the solar cycle affects the Doppler stability of integrated sunlight. Observations of integrated sunlight were made in the near infrared (approx. 2 micron), using the Kitt Peak McMath Fourier transform spectrometer, with a N2O gas absorption cell for calibration. An accuracy of approx. 5 meter/sec was achieved.

Studying the Ultraviolet Spectrum of the First Spectroscopically Confirmed Supernova at redshift two

DOE PAGES

Smith, M.

2017-12-11

Here, we present observations of DES16C2nm, the first spectroscopically confirmed hydrogen-free superluminous supernova (SLSN-I) at redshift z~2. DES16C2nm was discovered by the Dark Energy Survey (DES) Supernova Program, with follow-up photometric data from the Hubble Space Telescope, Gemini, and the European Southern Observatory Very Large Telescope supplementing the DES data. Spectroscopic observations confirm DES16C2nm to be at z=1.998, and spectroscopically similar to Gaia16apd (a SLSN-I at z=0.102), with a peak absolute magnitude of U=-22.26more » $$\\pm$$0.06. The high redshift of DES16C2nm provides a unique opportunity to study the ultraviolet (UV) properties of SLSNe-I. Combining DES16C2nm with ten similar events from the literature, we show that there exists a homogeneous class of SLSNe-I in the UV (~2500A), with peak luminosities in the (rest-frame) U band, and increasing absorption to shorter wavelengths. There is no evidence that the mean photometric and spectroscopic properties of SLSNe-I differ between low (z<1) and high redshift (z>1), but there is clear evidence of diversity in the spectrum at <2000A, possibly caused by the variations in temperature between events. No significant correlations are observed between spectral line velocities and photometric luminosity. Using these data, we estimate that SLSNe-I can be discovered to z=3.8 by DES. While SLSNe-I are typically identified from their blue observed colors at low redshift (z<1), we highlight that at z>2 these events appear optically red, peaking in the observer-frame z-band. Such characteristics are critical to identify these objects with future facilities such as the Large Synoptic Survey Telescope, Euclid, and the Wide-Field Infrared Survey Telescope, which should detect such SLSNe-I to z=3.5, 3.7, and 6.6, respectively.« less

Studying the Ultraviolet Spectrum of the First Spectroscopically Confirmed Supernova at Redshift Two

NASA Astrophysics Data System (ADS)

Smith, M.; Sullivan, M.; Nichol, R. C.; Galbany, L.; D’Andrea, C. B.; Inserra, C.; Lidman, C.; Rest, A.; Schirmer, M.; Filippenko, A. V.; Zheng, W.; Cenko, S. Bradley; Angus, C. R.; Brown, P. J.; Davis, T. M.; Finley, D. A.; Foley, R. J.; González-Gaitán, S.; Gutiérrez, C. P.; Kessler, R.; Kuhlmann, S.; Marriner, J.; Möller, A.; Nugent, P. E.; Prajs, S.; Thomas, R.; Wolf, R.; Zenteno, A.; Abbott, T. M. C.; Abdalla, F. B.; Allam, S.; Annis, J.; Bechtol, K.; Benoit-Lévy, A.; Bertin, E.; Brooks, D.; Burke, D. L.; Carnero Rosell, A.; Carrasco Kind, M.; Carretero, J.; Castander, F. J.; Crocce, M.; Cunha, C. E.; da Costa, L. N.; Davis, C.; Desai, S.; Diehl, H. T.; Doel, P.; Eifler, T. F.; Flaugher, B.; Fosalba, P.; Frieman, J.; García-Bellido, J.; Gaztanaga, E.; Gerdes, D. W.; Goldstein, D. A.; Gruen, D.; Gruendl, R. A.; Gschwend, J.; Gutierrez, G.; Honscheid, K.; James, D. J.; Johnson, M. W. G.; Kuehn, K.; Kuropatkin, N.; Li, T. S.; Lima, M.; Maia, M. A. G.; Marshall, J. L.; Martini, P.; Menanteau, F.; Miller, C. J.; Miquel, R.; Ogando, R. L. C.; Petravick, D.; Plazas, A. A.; Romer, A. K.; Rykoff, E. S.; Sako, M.; Sanchez, E.; Scarpine, V.; Schindler, R.; Schubnell, M.; Sevilla-Noarbe, I.; Smith, R. C.; Soares-Santos, M.; Sobreira, F.; Suchyta, E.; Swanson, M. E. C.; Tarle, G.; Walker, A. R.; The DES Collaboration

2018-02-01

We present observations of DES16C2nm, the first spectroscopically confirmed hydrogen-free superluminous supernova (SLSN-I) at redshift z≈ 2. DES16C2nm was discovered by the Dark Energy Survey (DES) Supernova Program, with follow-up photometric data from the Hubble Space Telescope, Gemini, and the European Southern Observatory Very Large Telescope supplementing the DES data. Spectroscopic observations confirm DES16C2nm to be at z = 1.998, and spectroscopically similar to Gaia16apd (a SLSN-I at z = 0.102), with a peak absolute magnitude of U=-22.26+/- 0.06. The high redshift of DES16C2nm provides a unique opportunity to study the ultraviolet (UV) properties of SLSNe-I. Combining DES16C2nm with 10 similar events from the literature, we show that there exists a homogeneous class of SLSNe-I in the UV ({λ }{rest}≈ 2500 Å), with peak luminosities in the (rest-frame) U band, and increasing absorption to shorter wavelengths. There is no evidence that the mean photometric and spectroscopic properties of SLSNe-I differ between low (z< 1) and high redshift (z> 1), but there is clear evidence of diversity in the spectrum at {λ }{rest}< 2000 \\mathringA , possibly caused by the variations in temperature between events. No significant correlations are observed between spectral line velocities and photometric luminosity. Using these data, we estimate that SLSNe-I can be discovered to z = 3.8 by DES. While SLSNe-I are typically identified from their blue observed colors at low redshift (z< 1), we highlight that at z> 2 these events appear optically red, peaking in the observer-frame z-band. Such characteristics are critical to identify these objects with future facilities such as the Large Synoptic Survey Telescope, Euclid, and the Wide-field Infrared Survey Telescope, which should detect such SLSNe-I to z = 3.5, 3.7, and 6.6, respectively.

Studying the Ultraviolet Spectrum of the First Spectroscopically Confirmed Supernova at redshift two

DOE Office of Scientific and Technical Information (OSTI.GOV)

Smith, M.

Here, we present observations of DES16C2nm, the first spectroscopically confirmed hydrogen-free superluminous supernova (SLSN-I) at redshift z~2. DES16C2nm was discovered by the Dark Energy Survey (DES) Supernova Program, with follow-up photometric data from the Hubble Space Telescope, Gemini, and the European Southern Observatory Very Large Telescope supplementing the DES data. Spectroscopic observations confirm DES16C2nm to be at z=1.998, and spectroscopically similar to Gaia16apd (a SLSN-I at z=0.102), with a peak absolute magnitude of U=-22.26more » $$\\pm$$0.06. The high redshift of DES16C2nm provides a unique opportunity to study the ultraviolet (UV) properties of SLSNe-I. Combining DES16C2nm with ten similar events from the literature, we show that there exists a homogeneous class of SLSNe-I in the UV (~2500A), with peak luminosities in the (rest-frame) U band, and increasing absorption to shorter wavelengths. There is no evidence that the mean photometric and spectroscopic properties of SLSNe-I differ between low (z<1) and high redshift (z>1), but there is clear evidence of diversity in the spectrum at <2000A, possibly caused by the variations in temperature between events. No significant correlations are observed between spectral line velocities and photometric luminosity. Using these data, we estimate that SLSNe-I can be discovered to z=3.8 by DES. While SLSNe-I are typically identified from their blue observed colors at low redshift (z<1), we highlight that at z>2 these events appear optically red, peaking in the observer-frame z-band. Such characteristics are critical to identify these objects with future facilities such as the Large Synoptic Survey Telescope, Euclid, and the Wide-Field Infrared Survey Telescope, which should detect such SLSNe-I to z=3.5, 3.7, and 6.6, respectively.« less

A photometrically and spectroscopically confirmed population of passive spiral galaxies

NASA Astrophysics Data System (ADS)

Fraser-McKelvie, Amelia; Brown, Michael J. I.; Pimbblet, Kevin A.; Dolley, Tim; Crossett, Jacob P.; Bonne, Nicolas J.

2016-10-01

We have identified a population of passive spiral galaxies from photometry and integral field spectroscopy. We selected z < 0.035 spiral galaxies that have WISE colours consistent with little mid-infrared emission from warm dust. Matched aperture photometry of 51 spiral galaxies in ultraviolet, optical and mid-infrared show these galaxies have colours consistent with passive galaxies. Six galaxies form a spectroscopic pilot study and were observed using the Wide-Field Spectrograph to check for signs of nebular emission from star formation. We see no evidence of substantial nebular emission found in previous red spiral samples. These six galaxies possess absorption-line spectra with 4000 Å breaks consistent with an average luminosity-weighted age of 2.3 Gyr. Our photometric and integral field spectroscopic observations confirm the existence of a population of local passive spiral galaxies, implying that transformation into early-type morphologies is not required for the quenching of star formation.

Model-data fusion across ecosystems: from multisite optimizations to global simulations

NASA Astrophysics Data System (ADS)

Kuppel, S.; Peylin, P.; Maignan, F.; Chevallier, F.; Kiely, G.; Montagnani, L.; Cescatti, A.

2014-11-01

This study uses a variational data assimilation framework to simultaneously constrain a global ecosystem model with eddy covariance measurements of daily net ecosystem exchange (NEE) and latent heat (LE) fluxes from a large number of sites grouped in seven plant functional types (PFTs). It is an attempt to bridge the gap between the numerous site-specific parameter optimization works found in the literature and the generic parameterization used by most land surface models within each PFT. The present multisite approach allows deriving PFT-generic sets of optimized parameters enhancing the agreement between measured and simulated fluxes at most of the sites considered, with performances often comparable to those of the corresponding site-specific optimizations. Besides reducing the PFT-averaged model-data root-mean-square difference (RMSD) and the associated daily output uncertainty, the optimization improves the simulated CO2 balance at tropical and temperate forests sites. The major site-level NEE adjustments at the seasonal scale are reduced amplitude in C3 grasslands and boreal forests, increased seasonality in temperate evergreen forests, and better model-data phasing in temperate deciduous broadleaf forests. Conversely, the poorer performances in tropical evergreen broadleaf forests points to deficiencies regarding the modelling of phenology and soil water stress for this PFT. An evaluation with data-oriented estimates of photosynthesis (GPP - gross primary productivity) and ecosystem respiration (Reco) rates indicates distinctively improved simulations of both gross fluxes. The multisite parameter sets are then tested against CO2 concentrations measured at 53 locations around the globe, showing significant adjustments of the modelled seasonality of atmospheric CO2 concentration, whose relevance seems PFT-dependent, along with an improved interannual variability. Lastly, a global-scale evaluation with remote sensing NDVI (normalized difference vegetation index

MASYS: The AKARI Spectroscopic Survey of Symbiotic Stars in the Magellanic Clouds

NASA Astrophysics Data System (ADS)

Angeloni, R.; Ciroi, S.; Marigo, P.; Contini, M.; Di Mille, F.; Rafanelli, P.

2009-12-01

MASYS is the AKARI spectroscopic survey of Symbiotic Stars in the Magellanic Clouds, and one of the European Open Time Observing Programmes approved for the AKARI (Post-Helium) Phase-3. It is providing the first ever near-IR spectra of extragalactic symbiotic stars. The observations are scheduled to be completed in July 2009.

Validation of Mismatch Negativity and P3a for Use in Multi-Site Studies of Schizophrenia: Characterization of Demographic, Clinical, Cognitive, and Functional Correlates in COGS-2

PubMed Central

Light, Gregory A.; Swerdlow, Neal R.; Thomas, Michael L.; Calkins, Monica E.; Green, Michael F.; Greenwood, Tiffany A.; Gur, Raquel E.; Gur, Ruben C.; Lazzeroni, Laura C.; Nuechterlein, Keith H.; Pela, Marlena; Radant, Allen D.; Seidman, Larry J.; Sharp, Richard F.; Siever, Larry J.; Silverman, Jeremy M.; Sprock, Joyce; Stone, William S.; Sugar, Catherine A.; Tsuang, Debby W.; Tsuang, Ming T.; Braff, David L.; Turetsky, Bruce I.

2014-01-01

Mismatch negativity (MMN) and P3a are auditory event-related potential (ERP) components that show robust deficits in schizophrenia (SZ) patients and exhibit qualities of endophenotypes, including substantial heritability, test-retest reliability, and trait-like stability. These measures also fulfill criteria for use as cognition and function-linked biomarkers in outcome studies, but have not yet been validated for use in large-scale multi-site clinical studies. This study tested the feasibility of adding MMN and P3a to the ongoing Consortium on the Genetics of Schizophrenia (COGS) study. The extent to which demographic, clinical, cognitive, and functional characteristics contribute to variability in MMN and P3a amplitudes was also examined. Participants (HCS n=824, SZ n=966) underwent testing at 5 geographically distributed COGS laboratories. Valid ERP data was obtained from 91% of HCS and 91% of SZ patients. Highly significant MMN (d=0.96) and P3a (d=0.93) amplitude reductions were observed in SZ patients, comparable in magnitude to those observed in single-lab studies with no appreciable differences across laboratories. Demographic characteristics accounted for 26% and 18% of the variance in MMN and P3a amplitudes, respectively. Significant relationships were observed among demographically-adjusted MMN and P3a measures and medication status as well as several clinical, cognitive, and functional characteristics of the SZ patients. This study demonstrates that MMN and P3a ERP biomarkers can be feasibly used in multi-site clinical studies. As with many clinical tests of brain function, demographic factors contribute to MMN and P3a amplitudes and should be carefully considered in future biomarker-informed clinical studies. PMID:25449710

An empirical evaluation of three vibrational spectroscopic methods for detection of aflatoxins in maize.

PubMed

Lee, Kyung-Min; Davis, Jessica; Herrman, Timothy J; Murray, Seth C; Deng, Youjun

2015-04-15

Three commercially available vibrational spectroscopic techniques, including Raman, Fourier transform near infrared reflectance (FT-NIR), and Fourier transform infrared (FTIR) were evaluated to help users determine the spectroscopic method best suitable for aflatoxin analysis in maize (Zea mays L.) grain based on their relative efficiency and predictive ability. Spectral differences of Raman and FTIR spectra were more marked and pronounced among aflatoxin contamination groups than those of FT-NIR spectra. From the observations and findings in our current and previous studies, Raman and FTIR spectroscopic methods are superior to FT-NIR method in terms of predictive power and model performance for aflatoxin analysis and they are equally effective and accurate in predicting aflatoxin concentration in maize. The present study is considered as the first attempt to assess how spectroscopic techniques with different physical processes can influence and improve accuracy and reliability for rapid screening of aflatoxin contaminated maize samples. Copyright © 2014 Elsevier Ltd. All rights reserved.

Spectroscopic mode identification of γ Doradus stars: frequencies, modes, rotation and wave leakage

NASA Astrophysics Data System (ADS)

Pollard, Karen R.; Brunsden, E.; Davie, M.; Greenwood, A.; Cottrell, P. L.

The gravity modes present in γ Doradus stars probe the deep stellar interiors and are thus of particular interest in asteroseismology. The MUSICIAN programme at the University of Canterbury has been successfully identifying frequencies and pulsation modes in many γ Doradus stars using hundreds of precise, high resolution spectroscopic observations obtained with the 1.0 m telescope and HERCULES spectrograph at the Mt John Observatory in New Zealand. In this paper we present a summary of our spectroscopic frequency and mode identifications. Of particular interest from our spectroscopic analyses are: the prevalence of (l, m) = 1, 1 modes in many γ Dor stars; the importance of stellar rotation in the interpretation of the frequency and mode identification; and finally, possible evidence of wave leakage in one of these stars.

Spectroscopic Classifications of Optical Transients with the Lick Shane 3-m telescope

NASA Astrophysics Data System (ADS)

Dimitriadis, G.; Foley, R. J.

2018-05-01

We report the following classifications of optical transients from spectroscopic observations with the Kast spectrograph on the Shane 3-m telescope. Targets were supplied by ATLAS, ASAS-SN, and the KEGS K2 SN search.

Spectroscopic classification of ASASSN-17rl as type Ib/c

NASA Astrophysics Data System (ADS)

Bose, S.; Chen, P.; Dong, Subo; Bersier, David; Prieto, J. L.

2018-01-01

We report optical spectroscopic observations of supernova candidate ASASSN-17rl / 2017jea (ATel #11103) done on UT 2017-12-28.47 with DBSP mounted on the Hale 5m telescope at Palomar Observatory and on 2018-01-11.92 with SPRAT mounted on the 2m Liverpool Telescope.

Spectroscopic studies of the molecular parentage of radical species in cometary comae

NASA Astrophysics Data System (ADS)

Lewis, Benjamin; Pierce, Donna; Cochran, Anita

2015-11-01

We have observed several comets using an integral-field unit spectrograph (the George and Cynthia Mitchell Spectrograph) on the 2.7m Harlan J. Smith telescope at McDonald Observatory. Full-coma spectroscopic images were obtained for various radical species (C2, C3, CH, CN, NH2). By constructing azimuthal average profiles from the full-coma spectroscopic images we can test Haser model parameters with our observations. The Haser model was used to determine production rates and possible parent lifetimes that would be consistent with the model. By iterating through a large range of possible parents lifetimes, we can see what range of values in which the Haser model is consistent with observations. Also, this type of analysis gives us perspective on how sensitive the model's fit quality is to changes in parent lifetimes. Here, we present the work completed to date, and we compare our results to other comet taxonomic surveys.

Multi-Site Quality Assurance Project Plan for Wisconsin Public Service Corporation, Peoples Gas Light and Coke Company, and North Shore Gas

EPA Pesticide Factsheets

This Multi-Site QAPP presents the organization, data quality objectives (DQOs), a set of anticipated activities, sample analysis, data handling and specific Quality Assurance/Quality Control (QA/QC) procedures associated with Studies done in EPA Region 5

Optimization of spectroscopic surveys for testing non-Gaussianity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Raccanelli, Alvise; Doré, Olivier; Dalal, Neal, E-mail: alvise@caltech.edu, E-mail: Olivier.P.Dore@jpl.nasa.gov, E-mail: dalaln@illinois.edu

We investigate optimization strategies to measure primordial non-Gaussianity with future spectroscopic surveys. We forecast measurements coming from the 3D galaxy power spectrum and compute constraints on primordial non-Gaussianity parameters f{sub NL} and n{sub NG}. After studying the dependence on those parameters upon survey specifications such as redshift range, area, number density, we assume a reference mock survey and investigate the trade-off between number density and area surveyed. We then define the observational requirements to reach the detection of f{sub NL} of order 1. Our results show that power spectrum constraints on non-Gaussianity from future spectroscopic surveys can improve on currentmore » CMB limits, but the multi-tracer technique and higher order correlations will be needed in order to reach an even better precision in the measurements of the non-Gaussianity parameter f{sub NL}.« less

Use of the World Wide Web for multisite data collection.

PubMed

Subramanian, A K; McAfee, A T; Getzinger, J P

1997-08-01

As access to the Internet becomes increasingly available, research applications in medicine will increase. This paper describes the use of the Internet, and, more specifically, the World Wide Web (WWW), as a channel of communication between EDs throughout the world and investigators who are interested in facilitating the collection of data from multiple sites. Data entered into user-friendly electronic surveys can be transmitted over the Internet to a database located at the site of the study, rendering geographic separation less of a barrier to the conduction of multisite studies. The electronic format of the data can enable real-time statistical processing while data are stored using existing database technologies. In theory, automated processing of variables within such a database enables early identification of data trends. Methods of ensuring validity, security, and compliance are discussed.

The opportunities and challenges of multi-site evaluations: lessons from the jail diversion and trauma recovery national cross-site evaluation.

PubMed

Stainbrook, Kristin; Penney, Darby; Elwyn, Laura

2015-06-01

Multi-site evaluations, particularly of federally funded service programs, pose a special set of challenges for program evaluation. Not only are there contextual differences related to project location, there are often relatively few programmatic requirements, which results in variations in program models, target populations and services. The Jail Diversion and Trauma Recovery-Priority to Veterans (JDTR) National Cross-Site Evaluation was tasked with conducting a multi-site evaluation of thirteen grantee programs that varied along multiple domains. This article describes the use of a mixed methods evaluation design to understand the jail diversion programs and client outcomes for veterans with trauma, mental health and/or substance use problems. We discuss the challenges encountered in evaluating diverse programs, the benefits of the evaluation in the face of these challenges, and offer lessons learned for other evaluators undertaking this type of evaluation. Copyright © 2015 Elsevier Ltd. All rights reserved.

NARROW-LINE X-RAY-SELECTED GALAXIES IN THE CHANDRA -COSMOS FIELD. I. OPTICAL SPECTROSCOPIC CATALOG

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pons, E.; Watson, M. G.; Elvis, M.

2016-04-20

The COSMOS survey is a large and deep survey with multiwavelength observations of sources from X-rays to the UV, allowing an extensive study of their properties. The central 0.9 deg{sup 2} of the COSMOS field have been observed by Chandra with a sensitivity up to 1.9 × 10{sup −16} erg cm{sup −2} s{sup −1} in the full (0.5–10 keV) band. Photometric and spectroscopic identification of the Chandra -COSMOS (C-COSMOS) sources is available from several catalogs and campaigns. Despite the fact that the C-COSMOS galaxies have a reliable spectroscopic redshift in addition to a spectroscopic classification, the emission-line properties of thismore » sample have not yet been measured. We present here the creation of an emission-line catalog of 453 narrow-line sources from the C-COSMOS spectroscopic sample. We have performed spectral fitting for the more common lines in galaxies ([O ii] λ 3727, [Ne iii] λ 3869, H β , [O iii] λλ 4959, 5007, H α , and [N ii] λλ 6548, 6584). These data provide an optical classification for 151 (i.e., 33%) of the C-COSMOS narrow-line galaxies based on emission-line diagnostic diagrams.« less

Spectroscopic characterization of galaxy clusters in RCS-1: spectroscopic confirmation, redshift accuracy, and dynamical mass-richness relation

NASA Astrophysics Data System (ADS)

Gilbank, David G.; Barrientos, L. Felipe; Ellingson, Erica; Blindert, Kris; Yee, H. K. C.; Anguita, T.; Gladders, M. D.; Hall, P. B.; Hertling, G.; Infante, L.; Yan, R.; Carrasco, M.; Garcia-Vergara, Cristina; Dawson, K. S.; Lidman, C.; Morokuma, T.

2018-05-01

We present follow-up spectroscopic observations of galaxy clusters from the first Red-sequence Cluster Survey (RCS-1). This work focuses on two samples, a lower redshift sample of ˜30 clusters ranging in redshift from z ˜ 0.2-0.6 observed with multiobject spectroscopy (MOS) on 4-6.5-m class telescopes and a z ˜ 1 sample of ˜10 clusters 8-m class telescope observations. We examine the detection efficiency and redshift accuracy of the now widely used red-sequence technique for selecting clusters via overdensities of red-sequence galaxies. Using both these data and extended samples including previously published RCS-1 spectroscopy and spectroscopic redshifts from SDSS, we find that the red-sequence redshift using simple two-filter cluster photometric redshifts is accurate to σz ≈ 0.035(1 + z) in RCS-1. This accuracy can potentially be improved with better survey photometric calibration. For the lower redshift sample, ˜5 per cent of clusters show some (minor) contamination from secondary systems with the same red-sequence intruding into the measurement aperture of the original cluster. At z ˜ 1, the rate rises to ˜20 per cent. Approximately ten per cent of projections are expected to be serious, where the two components contribute significant numbers of their red-sequence galaxies to another cluster. Finally, we present a preliminary study of the mass-richness calibration using velocity dispersions to probe the dynamical masses of the clusters. We find a relation broadly consistent with that seen in the local universe from the WINGS sample at z ˜ 0.05.

THE SDSS-IV EXTENDED BARYON OSCILLATION SPECTROSCOPIC SURVEY: OVERVIEW AND EARLY DATA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dawson, Kyle S.; Bautista, Julian E.; Kneib, Jean-Paul

In a six-year program started in 2014 July, the Extended Baryon Oscillation Spectroscopic Survey (eBOSS) will conduct novel cosmological observations using the BOSS spectrograph at Apache Point Observatory. These observations will be conducted simultaneously with the Time Domain Spectroscopic Survey (TDSS) designed for variability studies and the Spectroscopic Identification of eROSITA Sources (SPIDERS) program designed for studies of X-ray sources. In particular, eBOSS will measure with percent-level precision the distance-redshift relation with baryon acoustic oscillations (BAO) in the clustering of matter. eBOSS will use four different tracers of the underlying matter density field to vastly expand the volume covered bymore » BOSS and map the large-scale-structures over the relatively unconstrained redshift range 0.6 < z < 2.2. Using more than 250,000 new, spectroscopically confirmed luminous red galaxies at a median redshift z = 0.72, we project that eBOSS will yield measurements of the angular diameter distance d{sub A}(z) to an accuracy of 1.2% and measurements of H(z) to 2.1% when combined with the z > 0.6 sample of BOSS galaxies. With ∼195,000 new emission line galaxy redshifts, we expect BAO measurements of d{sub A}(z) to an accuracy of 3.1% and H(z) to 4.7% at an effective redshift of z = 0.87. A sample of more than 500,000 spectroscopically confirmed quasars will provide the first BAO distance measurements over the redshift range 0.9 < z < 2.2, with expected precision of 2.8% and 4.2% on d{sub A}(z) and H(z), respectively. Finally, with 60,000 new quasars and re-observation of 60,000 BOSS quasars, we will obtain new Lyα forest measurements at redshifts z > 2.1; these new data will enhance the precision of d{sub A}(z) and H(z) at z > 2.1 by a factor of 1.44 relative to BOSS. Furthermore, eBOSS will provide improved tests of General Relativity on cosmological scales through redshift-space distortion measurements, improved tests for

Spectroscopic Profiles of Comets Garradd and McNaught

NASA Astrophysics Data System (ADS)

Harris, Ien; Pierce, Donna M.; Cochran, Anita L.

2017-10-01

We have used the integral-field unit spectrograph (the George and Cynthia Mitchell Spectrograph) on the 2.7m Harlan J. Smith telescope at McDonald Observatory to obtain spectroscopic images of the comae of several comets. The images were obtained for various radical species (C2, C3, CN, NH2). Radial and azimuthal average profiles of the radical species were created to enhance any observed cometary coma morphological features. We compare the observed coma features across the observed species and over the different observation periods in order to constrain possible rotational states of the observed comets, as well as determine possible source differences in the coma between the observed radical species. We will present results for several comets, including C/2009 P1 (Garradd) and 260P (McNaught).

Analytic hierarchy process-based approach for selecting a Pareto-optimal solution of a multi-objective, multi-site supply-chain planning problem

NASA Astrophysics Data System (ADS)

Ayadi, Omar; Felfel, Houssem; Masmoudi, Faouzi

2017-07-01

The current manufacturing environment has changed from traditional single-plant to multi-site supply chain where multiple plants are serving customer demands. In this article, a tactical multi-objective, multi-period, multi-product, multi-site supply-chain planning problem is proposed. A corresponding optimization model aiming to simultaneously minimize the total cost, maximize product quality and maximize the customer satisfaction demand level is developed. The proposed solution approach yields to a front of Pareto-optimal solutions that represents the trade-offs among the different objectives. Subsequently, the analytic hierarchy process method is applied to select the best Pareto-optimal solution according to the preferences of the decision maker. The robustness of the solutions and the proposed approach are discussed based on a sensitivity analysis and an application to a real case from the textile and apparel industry.

Optical spectroscopic elucidation of beta-turns in disulfide bridged cyclic tetrapeptides.

PubMed

Borics, Attila; Murphy, Richard F; Lovas, Sándor

2007-01-01

Vibrational circular dichroism (VCD) spectroscopic features of type II beta-turns were characterized previously, but, criteria for differentiation between beta-turn types had not been established yet. Model tetrapeptides, cyclized through a disulfide bridge, were designed on the basis of previous experimental results and the observed incidence of amino acid residues in the i + 1 and i + 2 positions in beta-turns, to determine the features of VCD spectra of type I and II beta-turns. The results were correlated with electronic circular dichroism (ECD) spectra and VCD spectra calculated from conformational data obtained by molecular dynamics (MD) simulations. All cyclic tetrapeptides yielded VCD signals with a higher frequency negative and a lower frequency positive couplet with negative lobes overlapping. MD simulations confirmed the conformational homogeneity of these peptides in solution. Comparison with ECD spectroscopy, MD, and quantum chemical calculation results suggested that the low frequency component of VCD spectra originating from the tertiary amide vibrations could be used to distinguish between types of beta-turn structures. On the basis of this observation, VCD spectroscopic features of type II and VIII beta-turns and ECD spectroscopic properties of a type VIII beta-turn were suggested. The need for independent experimental as well as theoretical investigations to obtain decisive conformational information was recognized. Copyright 2006 Wiley Periodicals, Inc.

Overcoming the Challenges of Unstructured Data in Multisite, Electronic Medical Record-based Abstraction.

PubMed

Polnaszek, Brock; Gilmore-Bykovskyi, Andrea; Hovanes, Melissa; Roiland, Rachel; Ferguson, Patrick; Brown, Roger; Kind, Amy J H

2016-10-01

Unstructured data encountered during retrospective electronic medical record (EMR) abstraction has routinely been identified as challenging to reliably abstract, as these data are often recorded as free text, without limitations to format or structure. There is increased interest in reliably abstracting this type of data given its prominent role in care coordination and communication, yet limited methodological guidance exists. As standard abstraction approaches resulted in substandard data reliability for unstructured data elements collected as part of a multisite, retrospective EMR study of hospital discharge communication quality, our goal was to develop, apply and examine the utility of a phase-based approach to reliably abstract unstructured data. This approach is examined using the specific example of discharge communication for warfarin management. We adopted a "fit-for-use" framework to guide the development and evaluation of abstraction methods using a 4-step, phase-based approach including (1) team building; (2) identification of challenges; (3) adaptation of abstraction methods; and (4) systematic data quality monitoring. Unstructured data elements were the focus of this study, including elements communicating steps in warfarin management (eg, warfarin initiation) and medical follow-up (eg, timeframe for follow-up). After implementation of the phase-based approach, interrater reliability for all unstructured data elements demonstrated κ's of ≥0.89-an average increase of +0.25 for each unstructured data element. As compared with standard abstraction methodologies, this phase-based approach was more time intensive, but did markedly increase abstraction reliability for unstructured data elements within multisite EMR documentation.

Lessons learned from a practice-based, multi-site intervention study with nurse participants

PubMed Central

Friese, Christopher R.; Mendelsohn-Victor, Kari; Ginex, Pamela; McMahon, Carol M.; Fauer, Alex J.; McCullagh, Marjorie C.

2016-01-01

Purpose To identify challenges and solutions to the efficient conduct of a multi-site, practice-based randomized controlled trial to improve nurses’ adherence to personal protective equipment use in ambulatory oncology settings. Design The Drug Exposure Feedback and Education for Nurses’ Safety (DEFENS) study is a clustered, randomized, controlled trial. Participating sites are randomized to web-based feedback on hazardous drug exposures in the sites plus tailored messages to address barriers versus a control intervention of a web-based continuing education video. Approach The study principal investigator, the study coordinator, and two site leaders identified challenges to study implementation and potential solutions, plus potential methods to prevent logistical challenges in future studies. Findings Noteworthy challenges included variation in human subjects protection policies, grants and contracts budgeting, infrastructure for nursing-led research, and information technology variation. Successful strategies included scheduled web conferences, site-based study champions, site visits by the principal investigator, and centrally-based document preparation. Strategies to improve efficiency in future studies include early and continued engagement with contract personnel in sites, and proposed changes to the common rule concerning human subjects. The DEFENS study successfully recruited 393 nurses across 12 sites. To date, 369 have completed surveys and 174 nurses have viewed educational materials. Conclusions Multi-site studies of nursing personnel are rare and challenging to existing infrastructure. These barriers can be overcome with strong engagement and planning. Clinical Relevance Leadership engagement, onsite staff support, and continuous communication can facilitate successful recruitment to a workplace-based randomized, controlled behavioral trial. PMID:28098951

Characterization of plasmonic effects in thin films and metamaterials using spectroscopic ellipsometry

NASA Astrophysics Data System (ADS)

Oates, T. W. H.; Wormeester, H.; Arwin, H.

2011-12-01

In this article, spectroscopic ellipsometry studies of plasmon resonances at metal-dielectric interfaces of thin films are reviewed. We show how ellipsometry provides valuable non-invasive amplitude and phase information from which one can determine the effective dielectric functions, and how these relate to the material nanostructure and define exactly the plasmonic characteristics of the system. There are three related plasmons that are observable using spectroscopic ellipsometry; volume plasmon resonances, surface plasmon polaritons and particle plasmon resonances. We demonstrate that the established method of exploiting surface plasmon polaritons for chemical and biological sensing may be enhanced using the ellipsometric phase information and provide a comprehensive theoretical basis for the technique. We show how the particle and volume plasmon resonances in the ellipsometric spectra of nanoparticle films are directly related to size, surface coverage and constituent dielectric functions of the nanoparticles. The regularly observed splitting of the particle plasmon resonance is theoretically described using modified effective medium theories within the framework of ellipsometry. We demonstrate the wealth of information available from real-time in situ spectroscopic ellipsometry measurements of metal film deposition, including the evolution of the plasmon resonances and percolation events. Finally, we discuss how generalized and Mueller matrix ellipsometry hold great potential for characterizing plasmonic metamaterials and sub-wavelength hole arrays.

Ab initio study of the O4H(+) novel species: spectroscopic fingerprints to aid its observation.

PubMed

Xavier, F George D; Hernández-Lamoneda, Rámon

2015-06-28

A detailed ab initio characterization of the structural, energetic and spectroscopic properties of the novel O4H(+) species is presented. The equilibrium structures and relative energies of all multiplet states have been determined systematically by analyzing static and dynamical correlation effects. The two and three body dissociation processes have been studied and indicate the presence of conical intersections in various states including the ground state. Comparison with available thermochemical data is very good, supporting the applied methodology. The reaction, H3(+) + O4→ O4H(+) + H2, was found to be exothermic ΔH = -19.4 kcal mol(-1) and therefore, it is proposed that the product in the singlet state could be formed in the interstellar medium (ISM) via collision processes. To aid in its laboratory or radioastronomy detection in the interstellar medium we determined spectroscopic fingerprints. It is estimated for the most stable geometry of O4H(+) dipole allowed electronic transitions in the visible region at 429 nm and 666 nm, an intense band at 1745 cm(-1) in the infrared and signals at 40.6, 81.2 and 139.2 GHz in the microwave region at 10, 50 and 150 K respectively, relevant for detection in the ISM.

Comparison of non-invasive MRI measurements of cerebral blood flow in a large multisite cohort.

PubMed

Dolui, Sudipto; Wang, Ze; Wang, Danny Jj; Mattay, Raghav; Finkel, Mack; Elliott, Mark; Desiderio, Lisa; Inglis, Ben; Mueller, Bryon; Stafford, Randall B; Launer, Lenore J; Jacobs, David R; Bryan, R Nick; Detre, John A

2016-07-01

Arterial spin labeling and phase contrast magnetic resonance imaging provide independent non-invasive methods for measuring cerebral blood flow. We compared global cerebral blood flow measurements obtained using pseudo-continuous arterial spin labeling and phase contrast in 436 middle-aged subjects acquired at two sites in the NHLBI CARDIA multisite study. Cerebral blood flow measured by phase contrast (CBFPC: 55.76 ± 12.05 ml/100 g/min) was systematically higher (p < 0.001) and more variable than cerebral blood flow measured by pseudo-continuous arterial spin labeling (CBFPCASL: 47.70 ± 9.75). The correlation between global cerebral blood flow values obtained from the two modalities was 0.59 (p < 0.001), explaining less than half of the observed variance in cerebral blood flow estimates. Well-established correlations of global cerebral blood flow with age and sex were similarly observed in both CBFPCASL and CBFPC CBFPC also demonstrated statistically significant site differences, whereas no such differences were observed in CBFPCASL No consistent velocity-dependent effects on pseudo-continuous arterial spin labeling were observed, suggesting that pseudo-continuous labeling efficiency does not vary substantially across typical adult carotid and vertebral velocities, as has previously been suggested. Although CBFPCASL and CBFPC values show substantial similarity across the entire cohort, these data do not support calibration of CBFPCASL using CBFPC in individual subjects. The wide-ranging cerebral blood flow values obtained by both methods suggest that cerebral blood flow values are highly variable in the general population. © The Author(s) 2016.

Simultaneous Photometric and Spectroscopic Solution for AW Cam

NASA Astrophysics Data System (ADS)

Frey, J. R.; Angione, R. J.; Sievers, J. R.

2010-07-01

We present the first four color Stromgren uvby photometric observations of the eclipsing binary system AW Cam along with the first simultaneous photometric and spectroscopic solution. This solution produced a detached system with a mass ratio of 0.45 consisting of an A1 primary and an F8 secondary, both in the main sequence band. The Hipparcos/Tycho Catalogue gives V = 8.24 and a parallax = 2.17 mas.

Sensitivity of the Modified Children's Yale-Brown Obsessive Compulsive Scale to Detect Change: Results from Two Multi-Site Trials

ERIC Educational Resources Information Center

Scahill, Lawrence; Sukhodolsky, Denis G.; Anderberg, Emily; Dimitropoulos, Anastasia; Dziura, James; Aman, Michael G.; McCracken, James; Tierney, Elaine; Hallett, Victoria; Katz, Karol; Vitiello, Benedetto; McDougle, Christopher

2016-01-01

Repetitive behavior is a core feature of autism spectrum disorder. We used 8-week data from two federally funded, multi-site, randomized trials with risperidone conducted by the Research Units on Pediatric Psychopharmacology Autism Network to evaluate the sensitivity of the Children's Yale-Brown Obsessive Compulsive Scale modified for autism…

How Much Do the Effects of Education and Training Programs Vary across Sites? Evidence from Past Multisite Randomized Trials

ERIC Educational Resources Information Center

Weiss, Michael J.; Bloom, Howard S.; Verbitsky-Savitz, Natalya; Gupta, Himani; Vigil, Alma E.; Cullinan, Daniel N.

2017-01-01

Multisite trials, in which individuals are randomly assigned to alternative treatment arms within sites, offer an excellent opportunity to estimate the cross-site average effect of treatment assignment (intent to treat or ITT) "and" the amount by which this impact varies across sites. Although both of these statistics are substantively…

Distortions in Distributions of Impact Estimates in Multi-Site Trials: The Central Limit Theorem Is Not Your Friend

ERIC Educational Resources Information Center

May, Henry

2014-01-01

Interest in variation in program impacts--How big is it? What might explain it?--has inspired recent work on the analysis of data from multi-site experiments. One critical aspect of this problem involves the use of random or fixed effect estimates to visualize the distribution of impact estimates across a sample of sites. Unfortunately, unless the…

A Spectroscopic Survey and Analysis of Bright, Hydrogen-rich White Dwarfs

NASA Astrophysics Data System (ADS)

Gianninas, A.; Bergeron, P.; Ruiz, M. T.

2011-12-01

We have conducted a spectroscopic survey of over 1300 bright (V <= 17.5), hydrogen-rich white dwarfs based largely on the last published version of the McCook & Sion catalog. The complete results from our survey, including the spectroscopic analysis of over 1100 DA white dwarfs, are presented. High signal-to-noise ratio optical spectra were obtained for each star and were subsequently analyzed using our standard spectroscopic technique where the observed Balmer line profiles are compared to synthetic spectra computed from the latest generation of model atmospheres appropriate for these stars. First, we present the spectroscopic content of our sample, which includes many misclassifications as well as several DAB, DAZ, and magnetic white dwarfs. Next, we look at how the new Stark broadening profiles affect the determination of the atmospheric parameters. When necessary, specific models and analysis techniques are used to derive the most accurate atmospheric parameters possible. In particular, we employ M dwarf templates to obtain better estimates of the atmospheric parameters for those white dwarfs that are in DA+dM binary systems. Certain unique white dwarfs and double-degenerate binary systems are also analyzed in greater detail. We then examine the global properties of our sample including the mass distribution and their distribution as a function of temperature. We then proceed to test the accuracy and robustness of our method by comparing our results to those of other surveys such as SPY and Sloan Digital Sky Survey. Finally, we revisit the ZZ Ceti instability strip and examine how the determination of its empirical boundaries is affected by the latest line profile calculations. Based on observations made with ESO Telescopes at the La Silla or Paranal Observatories under program ID 078.D-0824(A).

Knowledge of practice: A multi-sited event ethnography of border security fairs in Europe and North America.

PubMed

Baird, Theodore

2017-06-01

This article takes the reader inside four border security fairs in Europe and North America to examine the knowledge practices of border security professionals. Building on the border security as practice research agenda, the analysis focuses on the production, circulation, and consumption of scarce forms of knowledge. To explore situated knowledge of border security practices, I develop an approach to multi-sited event ethnography to observe and interpret knowledge that may be hard to access at the security fairs. The analysis focuses on mechanisms for disseminating and distributing scarce forms of knowledge, technological materializations of situated knowledge, expressions of transversal knowledge of security problems, how masculinities structure knowledge in gendered ways, and how unease is expressed through imagined futures in order to anticipate emergent solutions to proposed security problems. The article concludes by reflecting on the contradictions at play at fairs and how to address such contradictions through alternative knowledges and practices.

Knowledge of practice: A multi-sited event ethnography of border security fairs in Europe and North America

PubMed Central

Baird, Theodore

2017-01-01

This article takes the reader inside four border security fairs in Europe and North America to examine the knowledge practices of border security professionals. Building on the border security as practice research agenda, the analysis focuses on the production, circulation, and consumption of scarce forms of knowledge. To explore situated knowledge of border security practices, I develop an approach to multi-sited event ethnography to observe and interpret knowledge that may be hard to access at the security fairs. The analysis focuses on mechanisms for disseminating and distributing scarce forms of knowledge, technological materializations of situated knowledge, expressions of transversal knowledge of security problems, how masculinities structure knowledge in gendered ways, and how unease is expressed through imagined futures in order to anticipate emergent solutions to proposed security problems. The article concludes by reflecting on the contradictions at play at fairs and how to address such contradictions through alternative knowledges and practices. PMID:29046601

OPTICAL SPECTROSCOPIC OBSERVATIONS OF GAMMA-RAY BLAZAR CANDIDATES. V. TNG, KPNO, AND OAN OBSERVATIONS OF BLAZAR CANDIDATES OF UNCERTAIN TYPE IN THE NORTHERN HEMISPHERE

DOE Office of Scientific and Technical Information (OSTI.GOV)

Álvarez Crespo, N.; Massaro, F.; Masetti, N.

The extragalactic γ-ray sky is dominated by emission from blazars, a peculiar class of active galactic nuclei. Many of the γ-ray sources included in the Fermi-Large Area Telescope Third Source catalog (3FGL) are classified as blazar candidates of uncertain type (BCUs) because there are no optical spectra available in the literature to confirm their nature. In 2013, we started a spectroscopic campaign to look for the optical counterparts of the BCUs and of the unidentified γ-ray sources to confirm their blazar nature. Whenever possible we also determine their redshifts. Here, we present the results of the observations carried out inmore » the northern hemisphere in 2013 and 2014 at the Telescopio Nazionale Galileo, Kitt Peak National Observatory, and Observatorio Astronómico Nacional in San Pedro Mártir. In this paper, we describe the optical spectra of 25 sources. We confirmed that all of the 15 BCUs observed in our campaign and included in our sample are blazars and we estimated the redshifts for three of them. In addition, we present the spectra for three sources classified as BL Lacs in the literature but with no optical spectra available to date. We found that one of them is a quasar (QSO) at a redshift of z = 0.208 and the other two are BL Lacs. Moreover, we also present seven new spectra for known blazars listed in the Roma-BZCAT that have an uncertain redshift or are classified as BL Lac candidates. We found that one of them, 5BZB J0724+2621, is a “changing look” blazar. According to the spectrum available in the literature, it was classified as a BL Lac, but in our observation we clearly detected a broad emission line that led us to classify this source as a QSO at z = 1.17.« less

Multiband Photometric and Spectroscopic Analysis of HV Cnc

NASA Astrophysics Data System (ADS)

Gökay, G.; Gürol, B.; Derman, E.

2013-11-01

In this paper, radial velocity and VI- and JHKS - (Two Micron All Sky Survey) band photometric data of the detached system HV Cnc have been analyzed. The primary component of HV Cnc, which is a member of the M67 cluster, is suspected to be either a blue straggler or turn-off star. The system is a single-lined spectroscopic binary and its light curve shows a total eclipse. Spectroscopic observations of the system revealed the third component, which shows contribution to the total light of the system. Light curve and radial velocity data have been analyzed using the Wilson-Devinney (W-D) code and JHKS filter definitions computed for the W-D code in this work. Our analysis shows that the mass and radius of the primary and secondary components are 1.31 M ⊙, 0.52 M ⊙, 1.87 R ⊙, and 0.48 R ⊙, respectively. All results are compared with previously published literature values and discussed.

The spectroscopic indistinguishability of red giant branch and red clump stars

NASA Astrophysics Data System (ADS)

Masseron, T.; Hawkins, K.

2017-01-01

Context. Stellar spectroscopy provides useful information on the physical properties of stars such as effective temperature, metallicity and surface gravity. However, those photospheric characteristics are often hampered by systematic uncertainties. The joint spectro-sismo project (APOGEE+Kepler, aka APOKASC) of field red giants has revealed a puzzling offset between the surface gravities (log g) determined spectroscopically and those determined using asteroseismology, which is largely dependent on the stellar evolutionary status. Aims: Therefore, in this letter, we aim to shed light on the spectroscopic source of the offset. Methods: We used the APOKASC sample to analyse the dependencies of the log g discrepancy as a function of stellar mass and stellar evolutionary status. We discuss and study the impact of some neglected abundances on spectral analysis of red giants, such as He and carbon isotopic ratio. Results: We first show that, for stars at the bottom of the red giant branch where the first dredge-up had occurred, the discrepancy between spectroscopic log g and asteroseismic log g depends on stellar mass. This seems to indicate that the log g discrepancy is related to CN cycling. Among the CN-cycled elements, we demonstrate that the carbon isotopic ratio (12C /13C) has the largest impact on stellar spectrum. In parallel, we observe that this log g discrepancy shows a similar trend as the 12C /13C ratios as expected by stellar evolution theory. Although we did not detect a direct spectroscopic signature of 13C, other corroborating evidences suggest that the discrepancy in log g is tightly correlated to the production of 13C in red giants. Moreover, by running the data-driven algorithm (the Cannon) on a synthetic grid trained on the APOGEE data, we try to evaluate more quantitatively the impact of various 12C /13C ratios. Conclusions: While we have demonstrated that 13C indeed impacts all parameters, the size of the impact is smaller than the observed offset

Validation of mismatch negativity and P3a for use in multi-site studies of schizophrenia: characterization of demographic, clinical, cognitive, and functional correlates in COGS-2.

PubMed

Light, Gregory A; Swerdlow, Neal R; Thomas, Michael L; Calkins, Monica E; Green, Michael F; Greenwood, Tiffany A; Gur, Raquel E; Gur, Ruben C; Lazzeroni, Laura C; Nuechterlein, Keith H; Pela, Marlena; Radant, Allen D; Seidman, Larry J; Sharp, Richard F; Siever, Larry J; Silverman, Jeremy M; Sprock, Joyce; Stone, William S; Sugar, Catherine A; Tsuang, Debby W; Tsuang, Ming T; Braff, David L; Turetsky, Bruce I

2015-04-01

Mismatch negativity (MMN) and P3a are auditory event-related potential (ERP) components that show robust deficits in schizophrenia (SZ) patients and exhibit qualities of endophenotypes, including substantial heritability, test-retest reliability, and trait-like stability. These measures also fulfill criteria for use as cognition and function-linked biomarkers in outcome studies, but have not yet been validated for use in large-scale multi-site clinical studies. This study tested the feasibility of adding MMN and P3a to the ongoing Consortium on the Genetics of Schizophrenia (COGS) study. The extent to which demographic, clinical, cognitive, and functional characteristics contribute to variability in MMN and P3a amplitudes was also examined. Participants (HCS n=824, SZ n=966) underwent testing at 5 geographically distributed COGS laboratories. Valid ERP recordings were obtained from 91% of HCS and 91% of SZ patients. Highly significant MMN (d=0.96) and P3a (d=0.93) amplitude reductions were observed in SZ patients, comparable in magnitude to those observed in single-lab studies with no appreciable differences across laboratories. Demographic characteristics accounted for 26% and 18% of the variance in MMN and P3a amplitudes, respectively. Significant relationships were observed among demographically-adjusted MMN and P3a measures and medication status as well as several clinical, cognitive, and functional characteristics of the SZ patients. This study demonstrates that MMN and P3a ERP biomarkers can be feasibly used in multi-site clinical studies. As with many clinical tests of brain function, demographic factors contribute to MMN and P3a amplitudes and should be carefully considered in future biomarker-informed clinical studies. Published by Elsevier B.V.

Mauna Kea Observatory infrared observations

NASA Technical Reports Server (NTRS)

Jefferies, J. T.

1974-01-01

Galactic and solar system infrared observations are reported using a broad variety of radiometric and spectroscopic instrumentation. Infrared programs and papers published during this period are listed.

Risk and direct protective factors for youth violence: results from the Centers for Disease Control and Prevention's Multisite Violence Prevention Project.

PubMed

Henry, David B; Tolan, Patrick H; Gorman-Smith, Deborah; Schoeny, Michael E

2012-08-01

This study was conducted as part of a multisite effort to examine risk and direct protective factors for youth violence. The goal was to identify those factors in the lives of young people that increase or decrease the risk of violence. These analyses fill an important gap in the literature, as few studies have examined risk and direct protective factors for youth violence across multiple studies. Data on 4432 middle-school youth, from the CDC Multisite Violence Prevention Project were used. Evaluations were made of effects of variables coded as risk and direct protective factors in the fall of 6th grade on violence measured in spring of 7th and 8th grades. Factors tested included depression, delinquency, alcohol and drug involvement, involvement in family activities, academic achievement, attitudes toward school, truancy, and peer deviance. Most variables were coded with two sets of dummy variables indicating risk and protective directions of effects. Results showed that higher teacher-rated study skills were associated with lower subsequent violence across genders and ethnic groups. Affiliation with deviant peers was significantly associated with increased subsequent violence among youth reporting their race/ethnicity as white or other, marginally associated with increased violence among African-American youth, and unrelated among Latino youth. This study identified some factors than should be areas of interest for effective prevention programs. Some ethnic differences also should be considered in planning of prevention. The CDC Multisite Violence Prevention Project completed enrollment prior to July 2005. Copyright © 2012. Published by Elsevier Inc.

Spectroscopic and theoretical constraints on the differentiation of planetesimals

NASA Astrophysics Data System (ADS)

Moskovitz, Nicholas A.

The differentiation of small proto-planetary bodies into metallic cores, silicate mantles and basaltic crusts was a common occurrence in the first few million years of Solar System history. In this thesis, observational and theoretical methods are employed to investigate this process. Particular focus is given to the basaltic, crustal remnants of those differentiated parent bodies. A visible-wavelength spectroscopic survey was designed and performed to constrain the population of basaltic asteroids in the Main Belt. The results of this survey were used to provide statistical constraints on the orbital and size-frequency distributions of these objects. These distributions imply that basaltic material is rare in the Main Belt (particularly beyond the 3:1 mean motion resonance at 2.5 AU), however relic fragments of crust from multiple differentiated parent bodies are likely present. To provide insight on the mineralogical diversity of basaltic asteroids in the Main Belt, we performed a series of near-infrared spectroscopic observations. We find that V-type asteroids in the inner belt have spectroscopic properties consistent with an origin from a single parent body, most likely the asteroid Vesta. Spectroscopic differences (namely band area ratio) between these asteroids and basaltic meteorites here on Earth are best explained by space weathering of the asteroid surfaces. We also report the discovery of unusual spectral properties for asteroid 10537 (1991 RY16), a V-type asteroid in the outer Main Belt that has an ambiguous mineralogical interpretation. We conclude this thesis with a theoretical investigation of the relevant stages in the process of differentiation. We show that if partial silicate melting occurs within the interior of a planetesimal then both core and crust formation could have happened on sub-million year (Myr) time scales. However, it is shown that the high temperatures necessary to facilitate these processes may have been affected by the migration

Using Spectroscopic Profiles to Study the Morphology of Comets

NASA Astrophysics Data System (ADS)

Harris, Ien; Pierce, Donna M.; Cochran, Anita L.

2016-10-01

We have used the integral-field unit spectrograph (the George and Cynthia Mitchell Spectrograph) on the 2.7m Harlan J. Smith telescope at McDonald Observatory to obtain spectroscopic images of the comae of several comets. The images were obtained for various radical species (C2, C3. CH, CN, NH2). Radial and azimuthal average profiles of the radical species were created to enhance any observed cometary coma morphological features. We compare the observed coma features across the observed species and over the different observation periods in order to constrain possible rotational states of the observed comets. We will present results for several comets, including 2009P1 (Garradd). This work was funded by NASA's Planetary Atmospheres program (Award No. NNX14AH186).

Interstellar Medium, Young Stars, and Astrometric Binaries in Galactic Archaeology Spectroscopic Surveys

NASA Astrophysics Data System (ADS)

Zwitter, T.; Kos, J.; Žerjal, M.; Traven, G.

2016-10-01

Current ongoing stellar spectroscopic surveys (RAVE, GALAH, Gaia-ESO, LAMOST, APOGEE, Gaia) are mostly devoted to studying Galactic archaeology and the structure of the Galaxy. But they allow also for important auxiliary science: (i) the Galactic interstellar medium can be studied in four dimensions (position in space plus radial velocity) through weak but numerous diffuse interstellar bands and atomic absorptions seen in spectra of background stars, (ii) emission spectra which are quite frequent even in field stars can serve as a good indicator of their youth, pointing e.g. to stars recently ejected from young stellar environments, (iii) an astrometric solution of the photocenter of a binary to be obtained by Gaia can yield accurate masses when joined by spectroscopic information obtained serendipitously during a survey. These points are illustrated by first results from the first three surveys mentioned above. These hint at the near future: spectroscopic studies of the dynamics of the interstellar medium can identify and quantify Galactic fountains which may sustain star formation in the disk by entraining fresh gas from the halo; RAVE already provided a list of ˜ 14,000 field stars with chromospheric emission in Ca II lines, to be supplemented by many more observations by Gaia in the same band, and by GALAH and Gaia-ESO observations of Balmer lines; several millions of astrometric binaries with periods up to a few years which are being observed by Gaia can yield accurate masses when supplemented with measurements from only a few high-quality ground based spectra.

Decoding the spectroscopic features and time scales of aqueous proton defects

NASA Astrophysics Data System (ADS)

Napoli, Joseph A.; Marsalek, Ondrej; Markland, Thomas E.

2018-06-01

Acid solutions exhibit a variety of complex structural and dynamical features arising from the presence of multiple interacting reactive proton defects and counterions. However, disentangling the transient structural motifs of proton defects in the water hydrogen bond network and the mechanisms for their interconversion remains a formidable challenge. Here, we use simulations treating the quantum nature of both the electrons and nuclei to show how the experimentally observed spectroscopic features and relaxation time scales can be elucidated using a physically transparent coordinate that encodes the overall asymmetry of the solvation environment of the proton defect. We demonstrate that this coordinate can be used both to discriminate the extremities of the features observed in the linear vibrational spectrum and to explain the molecular motions that give rise to the interconversion time scales observed in recent nonlinear experiments. This analysis provides a unified condensed-phase picture of the proton structure and dynamics that, at its extrema, encompasses proton sharing and spectroscopic features resembling the limiting Eigen [H3O(H2O)3]+ and Zundel [H(H2O)2]+ gas-phase structures, while also describing the rich variety of interconverting environments in the liquid phase.

Far Ultraviolet Spectroscopic Explorer Observations of the Seyfert 1.5 Galaxy NGC 5548 in a Low State

NASA Technical Reports Server (NTRS)

Brotherton, M. S.; Green, R. F.; Kriss, G. A.; Oegerle, W.; Kaiser, M. E.; Zheng, W.; Hutchings, J. B.; Fisher, Richard R. (Technical Monitor)

2001-01-01

We present far-ultraviolet spectra of the Seyfert 1.5 galaxy NGC 5548 obtained in 2000 June with the Far Ultraviolet Spectroscopic Explorer (FUSE). Our data span the observed wavelength range 915-1185 A at a resolution of approximately 20 km s(exp -1). The spectrum shows a weak continuum and emission from O VI (lambda)(lambda)1032, 1038, C III (lambda)977, and He II (lambda)1085. The FUSE data were obtained when the AGN (Active Galactic Nuclei) was in a low state, which has revealed strong, narrow O VI emission lines. We also resolve intrinsic, associated absorption lines of O VI and the Lyman series. Several distinct kinematic components are present, spanning a velocity range of approximately 0 to -1300 km s(exp -1) relative to systemic, with kinematic structure similar to that seen in previous observations of longer wavelength ultraviolet (UV) lines. We explore the relationships between the far-UV (ultraviolet) absorbers and those seen previously in the UV and X-rays. We find that the high-velocity UV absorption component is consistent with being low-ionization, contrary to some previous claims, and is consistent with its non-detection in high-resolution X-ray spectra. The intermediate velocity absorbers, at -300 to -400 km s(exp -1), show H I and O VI column densities consistent with having contributions from both a high-ionization X-ray absorber and a low-ionization UV absorber. No single far-UV absorbing component can be solely identified with the X-ray absorber.

BAT AGN Spectroscopic Survey - III. An Observed Link Between AGN Eddington Ratio and Narrow-Emission-Line Ratios

NASA Technical Reports Server (NTRS)

Oh, Kyuseok; Schawinski, Kevin; Koss, Michael; Trakhtenbrot, Benny; Lamperti, Isabella; Ricci, Claudio; Mushotzky, Richard; Veilleux, Sylvain; Berney, Simon; Crenshaw, D. Michael;

JWST NIRCam Time Series Observations

NASA Technical Reports Server (NTRS)

Greene, Tom; Schlawin, E.

2017-01-01

We explain how to make time-series observations with the Near-Infrared camera (NIRCam) science instrument of the James Webb Space Telescope. Both photometric and spectroscopic observations are described. We present the basic capabilities and performance of NIRCam and show examples of how to set its observing parameters using the Space Telescope Science Institute's Astronomer's Proposal Tool (APT).

Spectroscopic properties for identifying sapphire samples from Ban Bo Kaew, Phrae Province, Thailand

NASA Astrophysics Data System (ADS)

Mogmued, J.; Monarumit, N.; Won-in, K.; Satitkune, S.

2017-09-01

Gemstone commercial is a high revenue for Thailand especially ruby and sapphire. Moreover, Phrae is a potential gem field located in the northern part of Thailand. The studies of spectroscopic properties are mainly to identify gemstone using advanced techniques (e.g. UV-Vis-NIR spectrophotometry, FTIR spectrometry and Raman spectroscopy). Typically, UV-Vis-NIR spectrophotometry is a technique to study the cause of color in gemstones. FTIR spectrometry is a technique to study the functional groups in gem-materials. Raman pattern can be applied to identify the mineral inclusions in gemstones. In this study, the natural sapphires from Ban Bo Kaew were divided into two groups based on colors including blue and green. The samples were analyzed by UV-Vis-NIR spectrophotometer, FTIR spectrometer and Raman spectroscope for studying spectroscopic properties. According to UV-Vis-NIR spectra, the blue sapphires show higher Fe3+/Ti4+ and Fe2+/Fe3+ absorption peaks than those of green sapphires. Otherwise, green sapphires display higher Fe3+/Fe3+ absorption peaks than blue sapphires. The FTIR spectra of both blue and green sapphire samples show the absorption peaks of -OH,-CH and CO2. The mineral inclusions such as ferrocolumbite and rutile in sapphires from this area were observed by Raman spectroscope. The spectroscopic properties of sapphire samples from Ban Bo Kaew, Phrae Province, Thailand are applied to be the specific evidence for gemstone identification.

High-pressure spectroscopic measurement on diffusion with a diamond-anvil cell

NASA Astrophysics Data System (ADS)

Aoki, K.; Katoh, Eriko; Yamawaki, H.; Fujihisa, H.; Sakashita, M.

2003-04-01

We report a diamond-anvil-cell (DAC) technique developed for spectroscopic measurement on the diffusion process in molecular solids at high pressure. The diffusion processes of atoms, molecules, or their ionic species are investigated for a bilayer specimen by measuring the variation of infrared vibrational spectra with time. The experimental procedures for the protonic and molecular diffusion measurements on ice at 400 K and 10.2 GPa are presented as an example study. The in situ spectroscopic technique with a DAC significantly extends the pressure range accessible for diffusion measurement. The diffusion process at a rate of 10-16-10-14 m2/s can currently be observed at temperatures of 300-600 K and pressures up to several tens of gigaPascals.

Spectroscopic Classifications of AT2017fqf as SN Ia and AT2017fqk as SN II

NASA Astrophysics Data System (ADS)

Tartaglia, Leonardo; Valenti, Stefano; Bostroem, K. Azalee; Yang, Sheng; Hosseinzadeh, G.

2017-07-01

We report the following classifications of optical transients from spectroscopic observations with the Kast spectrograph on the Shane telescope. All observations were made on 2017 July 27 UT. Classifications were performed with SNID (Blondin & Tonry, 2007, ApJ, 666, 1024).

IUE observations of symbiotic stars

NASA Technical Reports Server (NTRS)

Hack, M.

1982-01-01

The main photometric and spectroscopic characteristics in the ultraviolet and visual range of the most extensively studied symbiotic stars are reviewed. The main data obtained with IUE concern: (1) the determination of the shape of the UV continuum, which, in some cases, proves without doubt the presence of a hot companion; and the determination of the interstellar extinction by means of the lambda 2200 feature; (2) the measurement of emission lines, which enables us to derive the electron temperature and density of the circumstellar envelope, and, taken together with those lines observed in the visual, give more complete information on which spectroscopic mechanisms operate in the envelope; (3) the observation of absorption lines in the UV, which are present in just a few cases.

NITROGEN ISOTOPIC RATIO OF COMETARY AMMONIA FROM HIGH-RESOLUTION OPTICAL SPECTROSCOPIC OBSERVATIONS OF C/2014 Q2 (LOVEJOY)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shinnaka, Yoshiharu; Kawakita, Hideyo, E-mail: yoshiharu.shinnaka@nao.ac.jp

The icy materials present in comets provide clues to the origin and evolution of our solar system and planetary systems. High-resolution optical spectroscopic observations of comet C/2014 Q2 (Lovejoy) were performed on 2015 January 11 (at 1.321 au pre-perihelion) with the High Dispersion Spectrograph mounted on the Subaru Telescope on Maunakea, Hawaii. We derive the {sup 14}N/{sup 15}N ratio of NH{sub 2} (126 ± 25), as well as the ortho-to-para abundance ratios (OPRs) of the H{sub 2}O{sup +} ion (2.77 ± 0.24) and NH{sub 2} (3.38 ± 0.07), which correspond to nuclear spin temperatures of >24 K (3 σ lowermore » limit) and 27 ± 2 K, respectively. We also derive the intensity ratio of the green-to-red doublet of forbidden oxygen lines (0.107 ± 0.007). The ammonia in the comet must have formed under low-temperature conditions at ∼10 K or less to reproduce the observed {sup 14}N/{sup 15}N ratio in this molecule if it is assumed that the {sup 15}N-fractionation of ammonia occurred via ion–molecule chemical reactions. However, this temperature is inconsistent with the nuclear spin temperatures of water and ammonia estimated from the OPRs. The interpretation of the nuclear spin temperature as the temperature at molecular formation may therefore be incorrect. An isotope-selective photodissociation of molecular nitrogen by protosolar ultraviolet radiation might play an important role in the {sup 15}N-fractionation observed in cometary volatiles.« less

Near-infrared Spectroscopic Observations of Comet C/2013 R1 (Lovejoy) by WINERED: CN Red-system Band Emission

NASA Astrophysics Data System (ADS)

Shinnaka, Yoshiharu; Kawakita, Hideyo; Kondo, Sohei; Ikeda, Yuji; Kobayashi, Naoto; Hamano, Satoshi; Sameshima, Hiroaki; Fukue, Kei; Matsunaga, Noriyuki; Yasui, Chikako; Izumi, Natsuko; Mizumoto, Misaki; Otsubo, Shogo; Takenaka, Keiichi; Watase, Ayaka; Kawanishi, Takafumi; Nakanishi, Kenshi; Nakaoka, Tetsuya

2017-08-01

Although high-resolution spectra of the CN red-system band are considered useful in cometary sciences, e.g., in the study of isotopic ratios of carbon and nitrogen in cometary volatiles, there have been few reports to date due to the lack of high-resolution (R ≡ λ/Δλ > 20,000) spectrographs in the near-infrared region around ˜1 μm. Here, we present the high-resolution emission spectrum of the CN red-system band in comet C/2013 R1 (Lovejoy), acquired by the near-infrared high-resolution spectrograph WINERED mounted on the 1.3 m Araki telescope at the Koyama Astronomical Observatory, Kyoto, Japan. We applied our fluorescence excitation models for CN, based on modern spectroscopic studies, to the observed spectrum of comet C/2013 R1 (Lovejoy) to search for CN isotopologues (13C14N and 12C15N). We used a CN fluorescence excitation model involving both a “pure” fluorescence excitation model for the outer coma and a “fully collisional” fluorescence excitation model for the inner coma region. Our emission model could reproduce the observed 12C14N red-system band of comet C/2013 R1 (Lovejoy). The derived mixing ratio between the two excitation models was 0.94(+0.02/-0.03):0.06(+0.03/-0.02), corresponding to the radius of the collision-dominant region of ˜800-1600 km from the nucleus. No isotopologues were detected. The observed spectrum is consistent, within error, with previous estimates in comets of 12C/13C (˜90) and 14N/15N (˜150).

The brain-derived neurotrophic factor pathway, life stress, and chronic multi-site musculoskeletal pain.

PubMed

Generaal, Ellen; Milaneschi, Yuri; Jansen, Rick; Elzinga, Bernet M; Dekker, Joost; Penninx, Brenda W J H

2016-01-01

Brain-derived neurotrophic factor (BDNF) disturbances and life stress, both independently and in interaction, have been hypothesized to induce chronic pain. We examined whether (a) the BDNF pathway (val(66)met genotype, gene expression, and serum levels), (b) early and recent life stress, and (c) their interaction are associated with the presence and severity of chronic multi-site musculoskeletal pain. Cross-sectional data are from 1646 subjects of the Netherlands Study of Depression and Anxiety. The presence and severity of chronic multi-site musculoskeletal pain were determined using the Chronic Pain Grade (CPG) questionnaire. The BDNF val(66)met polymorphism, BDNF gene expression, and BDNF serum levels were measured. Early life stress before the age of 16 was assessed by calculating a childhood trauma index using the Childhood Trauma Interview. Recent life stress was assessed as the number of recent adverse life events using the List of Threatening Events Questionnaire. Compared to val(66)val, BDNF met carriers more often had chronic pain, whereas no differences were found for BDNF gene expression and serum levels. Higher levels of early and recent stress were both associated with the presence and severity of chronic pain (p < 0.001). No interaction effect was found for the BDNF pathway with life stress in the associations with chronic pain presence and severity. This study suggests that the BDNF gene marks vulnerability for chronic pain. Although life stress did not alter the impact of BDNF on chronic pain, it seems an independent factor in the onset and persistence of chronic pain. © The Author(s) 2016.

Spectroscopic classification of SN 2017hro with NOT

NASA Astrophysics Data System (ADS)

Babooram, C.; Jormanainen, J.; Wagner, S.; Wierda, F.; Kuncarayakti, H.; Fedorets, G.; Dyrbye, S.

2017-11-01

We report the spectroscopic classification of supernova SN 2017hro (ATLAS17mwv) in host galaxy 2MASX J22161573+4003267. The observations were performed with the 2.56 m Nordic Optical Telescope equipped with ALFOSC (range 350-950 nm; resolution 1.6 nm) on 2017-11-01.8 UT. Survey Name | IAU Name | Discovery (UT) | Discovery mag | Observation (UT) | Redshift | Type | Phase | Notes ATLAS17mwv | SN 2017hro | 2017-10-28.3 | 18.765 | 2017-11-01.8 | 0.015 | II | around maximum | (1) (1) SN redshift is obtained from host emission lines and consistent with that derived from the SN spectrum.

Sources of Site Differences in the Efficacy of a Multisite Clinical Trial: The Treatment of SSRI-Resistant Depression in Adolescents

ERIC Educational Resources Information Center

Spirito, Anthony; Abebe, Kaleab Z.; Iyengar, Satish; Brent, David; Vitiello, Benedetto; Clarke, Gregory; Wagner, Karen Dineen; Asarnow, Joan; Emslie, Graham; Keller, Martin

2009-01-01

Site differences in treatment outcomes are not often highlighted when the results of multisite randomized clinical trials (MRCTs) are reported. The primary analyses of a 6-site MRCT, the Treatment of SSRI-Resistant Depression in Adolescents (TORDIA) study, showed substantial variation by site in the performance of a medication-only condition and a…

Evaluation of a multi-site program designed to strengthen relational bonds for siblings separated by foster care.

PubMed

Waid, Jeffrey; Wojciak, Armeda Stevenson

2017-10-01

Sibling relationships in foster care settings have received increased attention in recent years. Despite growing evidence regarding the protective potential of sibling relationships for youth in care, some sibling groups continue to experience foster care related separation, and few programs exist to address the needs of these youth. This study describes and evaluates Camp To Belong, a multi-site program designed to provide short-term reunification to separated sibling groups through a week-long summer camp experience. Using a pre-test post-test survey design, this paper examines changes in youth ratings of sibling conflict and sibling support across camps located in six geographically distinct regions of the United States. The effects of youth age, number of prior camp exposures, and camp location were tested using multilevel modeling procedures. Findings suggest that participation in Camp To Belong may reduce sibling conflict, and improvements in sibling support are noted for youth who have had prior exposure to the camp's programming. Camp-level variance in the sibling support outcome highlight the complex nature of relationships for siblings separated by foster care, and suggest the need for additional research. Lessons learned from this multi-site evaluation and future directions are discussed. Copyright © 2017 Elsevier Ltd. All rights reserved.

Ten Steps to Conducting a Large, Multi-Site, Longitudinal Investigation of Language and Reading in Young Children

PubMed Central

Farquharson, Kelly; Murphy, Kimberly A.

2016-01-01

Purpose: This paper describes methodological procedures involving execution of a large-scale, multi-site longitudinal study of language and reading comprehension in young children. Researchers in the Language and Reading Research Consortium (LARRC) developed and implemented these procedures to ensure data integrity across multiple sites, schools, and grades. Specifically, major features of our approach, as well as lessons learned, are summarized in 10 steps essential for successful completion of a large-scale longitudinal investigation in early grades. Method: Over 5 years, children in preschool through third grade were administered a battery of 35 higher- and lower-level language, listening, and reading comprehension measures (RCM). Data were collected from children, their teachers, and their parents/guardians at four sites across the United States. Substantial and rigorous effort was aimed toward maintaining consistency in processes and data management across sites for children, assessors, and staff. Conclusion: With appropriate planning, flexibility, and communication strategies in place, LARRC developed and executed a successful multi-site longitudinal research study that will meet its goal of investigating the contribution and role of language skills in the development of children's listening and reading comprehension. Through dissemination of our design strategies and lessons learned, research teams embarking on similar endeavors can be better equipped to anticipate the challenges. PMID:27064308

Raman Spectroscopic Imaging of the Whole Ciona intestinalis Embryo during Development

PubMed Central

Nakamura, Mitsuru J.; Hotta, Kohji; Oka, Kotaro

2013-01-01

Intracellular composition and the distribution of bio-molecules play central roles in the specification of cell fates and morphogenesis during embryogenesis. Consequently, investigation of changes in the expression and distribution of bio-molecules, especially mRNAs and proteins, is an important challenge in developmental biology. Raman spectroscopic imaging, a non-invasive and label-free technique, allows simultaneous imaging of the intracellular composition and distribution of multiple bio-molecules. In this study, we explored the application of Raman spectroscopic imaging in the whole Ciona intestinalis embryo during development. Analysis of Raman spectra scattered from C. intestinalis embryos revealed a number of localized patterns of high Raman intensity within the embryo. Based on the observed distribution of bio-molecules, we succeeded in identifying the location and structure of differentiated muscle and endoderm within the whole embryo, up to the tailbud stage, in a label-free manner. Furthermore, during cell differentiation, we detected significant differences in cell state between muscle/endoderm daughter cells and daughter cells with other fates that had divided from the same mother cells; this was achieved by focusing on the Raman intensity of single Raman bands at 1002 or 1526 cm−1, respectively. This study reports the first application of Raman spectroscopic imaging to the study of identifying and characterizing differentiating tissues in a whole chordate embryo. Our results suggest that Raman spectroscopic imaging is a feasible label-free technique for investigating the developmental process of the whole embryo of C. intestinalis. PMID:23977129

Designing an audio computer-assisted self-interview (ACASI) system in a multisite trial: a brief report.

PubMed

2008-09-01

To describe the advantages and limitations of an audio computer-assisted self-interview (ACASI) system in a multisite trial with African American couples and to present the steps in designing, testing, and implementing a system. The ACASI system evolved from a paper and pencil interview that was pilot tested. Based on this initial work, the paper and pencil interview was translated into storyboards that were the basis of the development of ACASI system. Storyboards consisted of 1 page per question and provided the programmers with the test of the question, valid responses, and any instructions that were to be read to the participants. Storyboards were further translated into flow diagrams representing each module of the survey and illustrating the skip patterns used to navigate a participant through the survey. Provisions were also made to insert a face-to-face interview, into the ACASI assessment process, to elicit sexual abuse history data, which typically requires specially trained data collectors with active listening skills to help participants reframe and coordinate times, places and, emotionally difficult memories. The ACASI was successfully developed and implemented in the main trial. During an exit interview, respondents indicated that they liked using the ACASI and indicating that they favored it as the method to answer questions. It is feasible to implement an ACASI system in a multisite study in a timely and efficient way.

Demographic characteristics and employment among people with severe mental illness in a multisite study.

PubMed

Burke-Miller, Jane K; Cook, Judith A; Grey, Dennis D; Razzano, Lisa A; Blyler, Crystal R; Leff, H Stephen; Gold, Paul B; Goldberg, Richard W; Mueser, Kim T; Cook, William L; Hoppe, Sue K; Stewart, Michelle; Blankertz, Laura; Dudek, Kenn; Taylor, Amanda L; Carey, Martha Ann

2006-04-01

People with psychiatric disabilities experience disproportionately high rates of unemployment. As research evidence is mounting regarding effective vocational programs, interest is growing in identifying subgroup variations. Data from a multisite research and demonstration program were analyzed to identify demographic characteristics associated with employment outcomes, after adjusting for the effects of program, services, and study site. Longitudinal analyses found that people with more recent work history, younger age, and higher education were more likely to achieve competitive employment and to work more hours per month, while race and gender effects varied by employment outcome. Results provide strong evidence of demographic subgroup variation and need.

Neutron Spectroscopic Factors from Transfer Reactions

NASA Astrophysics Data System (ADS)

Lee, Jenny; Tsang, M. B.

2007-05-01

We have extracted the ground state to ground state neutron spectroscopic factors for 80 nuclei ranging in Z from 3 to 24 by analyzing the past measurements of the angular distributions from (d,p) and (p,d) reactions. We demonstrate an approach that provides systematic and consistent values with a minimum of assumptions. A three-body model with global optical potentials and standard geometry of n-potential is applied. For the 60 nuclei where modern shell model calculations are available, such analysis reproduces, to within 20%, the experimental spectroscopic factors for most nuclei. If we constraint the nucleon-target optical potential and the geometries of the bound neutron-wave function with the modern Hartree-Fock calculations, our deduced neutron spectroscopic factors are reduced by 30% on average.

Study of spectroscopic properties of nanosized particles of core-shell morphology

NASA Astrophysics Data System (ADS)

Bzhalava, T. N.; Kervalishvili, P. J.

2018-03-01

Method of studying spectroscopic properties of nanosized particles and estimation of resonance wavelength range for determination of specific and unique “spectral” signatures in purpose of sensing, identification of nanobioparticles, viruses is proposed. Elaboration of relevant models of viruses, estimation of spectral response on interaction of electromagnetic (EM) field and viral nanoparticle is the goal of proposed methodology. Core-shell physical model is used as the first approximation of shape-structure of virion. Theoretical solution of EM wave scattering on single spherical virus-like particle (VLP) is applied for determination of EM fields in the areas of core, shell and surrounding medium of (VLP), as well as scattering and absorption characteristics. Numerical results obtained by computer simulation for estimation of EM “spectra” of bacteriophage T7 demonstrate the strong dependence of spectroscopic characteristics on core-shell related electric and geometric parameters of VLP in resonance wavelengths range. Expected spectral response is observable on far-field characterizations. Obtained analytical EM field expressions, modelling technique in complement with experimental spectroscopic methods should be the way of providing the virus spectral signatures, important in bioparticles characterization.

Spectroscopic Classification of DLT18w/AT2018bko with SOAR

NASA Astrophysics Data System (ADS)

Pan, Y.-C.; Foley, R. J.

2018-05-01

< p > We report the classification of DLT18w/AT2018bko (ATel #11638) from spectroscopic observation performed on 2018 May 13 UT with the Goodman spectrograph on the Southern Astrophysical Research (SOAR) telescope. The spectrum appears to be blue and shows Balmer absorption lines at z=0, indicating that the transient is Galactic.

NOSD-1000, the high-temperature nitrous oxide spectroscopic databank

NASA Astrophysics Data System (ADS)

Tashkun, S. A.; Perevalov, V. I.; Lavrentieva, N. N.

2016-07-01

We present a high-temperature version, NOSD-1000, of the nitrous oxide spectroscopic databank. The databank contains the line parameters (positions, intensities, air- and self-broadened half-widths and coefficients of temperature dependence of air- and self-broadened half-widths) of the most abundant isotopologue 14N216O of the nitrous oxide molecule. The reference temperature is Tref=1000 K and the intensity cutoff is Icut=10-25 cm-1/(molecule cm-2). More than 1.4 million lines covering the 260-8310 cm-1 spectral range are included in NOSD-1000. The databank has been generated within the framework of the method of effective operators and based on the global fittings of spectroscopic parameters (parameters of the effective Hamiltonian and effective dipole moment operators) to observed data collected from the literature. Line-by-line simulation of a medium-resolution high-temperature (T=873 K) spectrum has been performed in order to validate the databank. NOSD-1000 is freely accessible via the Internet.

MULTIBAND PHOTOMETRIC AND SPECTROSCOPIC ANALYSIS OF HV Cnc

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gökay, G.; Gürol, B.; Derman, E., E-mail: ggokay@science.ankara.edu.tr

2013-11-01

In this paper, radial velocity and VI- and JHK{sub S} - (Two Micron All Sky Survey) band photometric data of the detached system HV Cnc have been analyzed. The primary component of HV Cnc, which is a member of the M67 cluster, is suspected to be either a blue straggler or turn-off star. The system is a single-lined spectroscopic binary and its light curve shows a total eclipse. Spectroscopic observations of the system revealed the third component, which shows contribution to the total light of the system. Light curve and radial velocity data have been analyzed using the Wilson-Devinney (W-D)more » code and JHK{sub S} filter definitions computed for the W-D code in this work. Our analysis shows that the mass and radius of the primary and secondary components are 1.31 M {sub ☉}, 0.52 M {sub ☉}, 1.87 R {sub ☉}, and 0.48 R {sub ☉}, respectively. All results are compared with previously published literature values and discussed.« less

Molecular weight, polydispersity, and spectroscopic properties of aquatic humic substances

USGS Publications Warehouse

Chin, Y.-P.; Aiken, G.; O'Loughlin, E.

1994-01-01

The number- and weight-averaged molecular weights of a number of aquatic fulvic acids, a commercial humic acid, and unfractionated organic matter from four natural water samples were measured by high-pressure size exclusion chromatography (HPSEC). Molecular weights determined in this manner compared favorably with those values reported in the literature. Both recent literature values and our data indicate that these substances are smaller and less polydisperse than previously believed. Moreover, the molecular weights of the organic matter from three of the four natural water samples compared favorably to the fulvic acid samples extracted from similar environments. Bulk spectroscopic properties of the fulvic substances such as molar absorptivity at 280 nm and the E4/E6 ratio were also measured. A strong correlation was observed between molar absorptivity, total aromaticity, and the weight average molecular weights of all the humic substances. This observation suggests that bulk spectroscopic properties can be used to quickly estimate the size of humic substances and their aromatic contents. Both parameters are important with respect to understanding humic substance mobility and their propensity to react with both organic and inorganic pollutants. ?? 1994 American Chemical Society.

THE YOUNG SOLAR ANALOGS PROJECT. I. SPECTROSCOPIC AND PHOTOMETRIC METHODS AND MULTI-YEAR TIMESCALE SPECTROSCOPIC RESULTS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gray, R. O.; Briley, M. M.; Lambert, R. A.

2015-12-15

This is the first in a series of papers presenting methods and results from the Young Solar Analogs Project, which began in 2007. This project monitors both spectroscopically and photometrically a set of 31 young (300–1500 Myr) solar-type stars with the goal of gaining insight into the space environment of the Earth during the period when life first appeared. From our spectroscopic observations we derive the Mount Wilson S chromospheric activity index (S{sub MW}), and describe the method we use to transform our instrumental indices to S{sub MW} without the need for a color term. We introduce three photospheric indicesmore » based on strong absorption features in the blue-violet spectrum—the G-band, the Ca i resonance line, and the Hydrogen-γ line—with the expectation that these indices might prove to be useful in detecting variations in the surface temperatures of active solar-type stars. We also describe our photometric program, and in particular our “Superstar technique” for differential photometry which, instead of relying on a handful of comparison stars, uses the photon flux in the entire star field in the CCD image to derive the program star magnitude. This enables photometric errors on the order of 0.005–0.007 magnitude. We present time series plots of our spectroscopic data for all four indices, and carry out extensive statistical tests on those time series demonstrating the reality of variations on timescales of years in all four indices. We also statistically test for and discover correlations and anti-correlations between the four indices. We discuss the physical basis of those correlations. As it turns out, the “photospheric” indices appear to be most strongly affected by emission in the Paschen continuum. We thus anticipate that these indices may prove to be useful proxies for monitoring emission in the ultraviolet Balmer continuum. Future papers in this series will discuss variability of the program stars on medium (days�

NIRcam-NIRSpec GTO Observations of Galaxy Evolution

NASA Astrophysics Data System (ADS)

Rieke, Marcia J.; Ferruit, Pierre; Alberts, Stacey; Bunker, Andrew; Charlot, Stephane; Chevallard, Jacopo; Dressler, Alan; Egami, Eiichi; Eisenstein, Daniel; Endsley, Ryan; Franx, Marijn; Frye, Brenda L.; Hainline, Kevin; Jakobsen, Peter; Lake, Emma Curtis; Maiolino, Roberto; Rix, Hans-Walter; Robertson, Brant; Stark, Daniel; Williams, Christina; Willmer, Christopher; Willott, Chris J.

2017-06-01

The NIRSpec and and NIRCam GTO Teams are planning a joint imaging and spectroscopic study of the high redshift universe. By virtue of planning a joint program which includes medium and deep near- and mid-infrared imaging surveys and multi-object spectroscopy (MOS) of sources in the same fields, we have learned much about planning observing programs for each of the instruments and using them in parallel mode to maximize photon collection time. The design and rationale for our joint program will be explored in this talk with an emphasis on why we have chosen particular suites of filters and spectroscopic resolutions, why we have chosen particular exposure patterns, and how we have designed the parallel observations. The actual observations that we intend on executing will serve as examples of how to layout mosaics and MOS observations to maximize observing efficiency for surveys with JWST.

Spectroscopic and Photometric Properties of Carbon Stars in the Disk of the Andromeda Galaxy

NASA Astrophysics Data System (ADS)

Guhathakurta, Puragra; Toloba, E.; Guha, S.; Rushing, C.; Dorman, C.; PHAT Collaboration; SPLASH Collaboration

2013-01-01

We explore the spectroscopic properties of a couple hundred carbon stars discovered in the disk of the Andromeda galaxy (M31) in the course of the Spectroscopic and Photometric Landscape of Andromeda's Stellar Halo (SPLASH) survey. The spectra were obtained using the DEIMOS spectrograph on the Keck II 10-meter telescope. About 5000 stars were targeted for spectroscopy during observing runs in 2010 and 2011 using DEIMOS's 1200 lines/mm grating with a spectral resolving power of R ~ 5000 to 6000 and spectral coverage from 6500-9000 Angstrom. In September 2012, another 5000 stars were observed this time with the 600 lines/mm grating and R ~ 2500 and spectral coverage from 4500-9000 Angstrom. For both types of spectroscopic observations, targets were selected from the Panchromatic Hubble Andromeda Treasury (PHAT) multi-cycle treasury program with the Hubble Space Telescope. Six-filter photometry in the ultraviolet (F275W, F336W), optical (F439W, F814W), and near infrared (F110W, F160W) is available for most targets. These carbon star samples are used to constrain the intermediage-age population in M31's disk. They are also compared to spectra of previously known carbon samples in the dwarf elliptical satellites of M31, NGC 147, NGC 185, and NGC 205. The authors thank the National Science Foundation, NASA/STScI, and UCSC's Summer Internship Program for support.

First High-resolution Spectroscopic Observations by IRIS of a Fast, Helical Prominence Eruption Associated with a Coronal Mass Ejection

NASA Astrophysics Data System (ADS)

Liu, W.; De Pontieu, B.; Okamoto, T. J.; Vial, J. C.; Title, A. M.; Antolin, P.; Berger, T. E.; Uitenbroek, H.

2014-12-01

High-resolution spectroscopic observations of prominence eruptions and associated coronal mass ejections (CMEs) are rare but can provide valuable plasma and energy diagnostics. New opportunities have recently become available with the advent of the Interface Region Imaging Spectrograph (IRIS) mission equipped with high resolution of 0.33-0.4 arcsec in space and 1 km/s in velocity, together with the Hinode Solar Optical Telescope of 0.2 arcsec spatial resolution. We report the first result of joint IRIS-Hinode observations of a spectacular prominence eruption occurring on 2014-May-09. IRIS detected a maximum redshift of 450 km/s, which, combined with the plane-of-sky speed of 800 km/s, gives a large velocity vector of 920 km/s at 30 degrees from the sky plane. This direction agrees with the source location at 30 degrees behind the limb observed by STEREO-A and indicates a nearly vertical ejection. We found two branches of redshifts separated by 200 km/s appearing in all strong lines at chromospheric to transition-region temperatures, including Mg II k/h, C II, and Si IV, suggesting a hollow, rather than solid, cone in the velocity space of the ejected material. Opposite blue- and redshifts on the two sides of the prominence exhibit corkscrew variations both in space and time, suggestive of unwinding rotations of a left-handed helical flux rope. Some erupted material returns as nearly streamline flows, exhibiting distinctly narrow line widths (~10 km/s), about 50% of those of the nearby coronal rain at the apexes of coronal loops, where the rain material is initially formed out of cooling condensation. We estimate the mass and kinetic energy of the ejected and returning material and compare them with those of the associated CME. We will discuss the implications of these observations for CME initiation mechanisms.

Localized and Spectroscopic Orbitals: Squirrel Ears on Water.

ERIC Educational Resources Information Center

Martin, R. Bruce

1988-01-01

Reexamines the electronic structure of water considering divergent views. Discusses several aspects of molecular orbital theory using spectroscopic molecular orbitals and localized molecular orbitals. Gives examples for determining lowest energy spectroscopic orbitals. (ML)

SPECTROSCOPIC AND PHOTOMETRIC VARIABILITY IN THE A0 SUPERGIANT HR 1040

DOE Office of Scientific and Technical Information (OSTI.GOV)

Corliss, David J.; Morrison, Nancy D.; Adelman, Saul J., E-mail: david.corliss@wayne.edu

2015-12-15

A time-series analysis of spectroscopic and photometric observables of the A0 Ia supergiant HR 1040 has been performed, including equivalent widths, radial velocities, and Strömgren photometric indices. The data, obtained from 1993 through 2007, include 152 spectroscopic observations from the Ritter Observatory 1 m telescope and 269 Strömgren photometric observations from the Four College Automated Photoelectric Telescope. Typical of late B- and early A-type supergiants, HR 1040 has a highly variable Hα profile. The star was found to have an intermittent active phase marked by correlation between the Hα absorption equivalent width and blue-edge radial velocity and by photospheric connectionsmore » observed in correlations to equivalent width, second moment and radial velocity in Si ii λλ6347, 6371. High-velocity absorption (HVA) events were observed only during this active phase. HVA events in the wind were preceded by photospheric activity, including Si ii radial velocity oscillations 19–42 days prior to onset of an HVA event and correlated increases in Si ii W{sub λ} and second moment from 13 to 23 days before the start of the HVA event. While increases in various line equivalent widths in the wind prior to HVA events have been reported in the past in other stars, our finding of precursors in enhanced radial velocity variations in the wind and at the photosphere is a new result.« less

The Galactic O-Star Catalog (GOSC) and the Galactic O-Star Spectroscopic Survey (GOSSS): current status

NASA Astrophysics Data System (ADS)

Maíz Apellániz, J.; Alonso Moragón, A.; Ortiz de Zárate Alcarazo, L.; The Gosss Team

2017-03-01

We present the updates of the Galactic O-Star Catalog (GOSC) that we have undertaken in the last two years: new spectral types, more objects, additional information, and coordination with CDS. We also present updates for the Galactic O-Star Spectroscopic Survey (GOSSS). A new paper (GOSSS-III) has been published and ˜ 1000 targets have been observed since 2014. Four new setups have been added to our lineup and for two of them we have already obtained over 100 spectra: with OSIRIS at the 10.4 m GTC we are observing northern dim stars and with FRODOspec at the 2.0 m Liverpool Telescope we are observing northern bright stars. Finally, we also make available new versions of MGB, the spectral classification tool associated with the project, and of the GOSSS grid of spectroscopic standards.

An ALMA Survey of Submillimeter Galaxies in the Extended Chandra Deep Field South: Spectroscopic Redshifts

NASA Astrophysics Data System (ADS)

Danielson, A. L. R.; Swinbank, A. M.; Smail, Ian; Simpson, J. M.; Casey, C. M.; Chapman, S. C.; da Cunha, E.; Hodge, J. A.; Walter, F.; Wardlow, J. L.; Alexander, D. M.; Brandt, W. N.; de Breuck, C.; Coppin, K. E. K.; Dannerbauer, H.; Dickinson, M.; Edge, A. C.; Gawiser, E.; Ivison, R. J.; Karim, A.; Kovacs, A.; Lutz, D.; Menten, K.; Schinnerer, E.; Weiß, A.; van der Werf, P.

2017-05-01

We present spectroscopic redshifts of {\\text{}}{S}870μ {{m}} ≳ 2 mJy submillimeter galaxies (SMGs), which have been identified from the ALMA follow-up observations of 870 μm detected sources in the Extended Chandra Deep Field South (the ALMA-LESS survey). We derive spectroscopic redshifts for 52 SMGs, with a median of z = 2.4 ± 0.1. However, the distribution features a high-redshift tail, with ˜23% of the SMGs at z≥slant 3. Spectral diagnostics suggest that the SMGs are young starbursts, and the velocity offsets between the nebular emission and UV ISM absorption lines suggest that many are driving winds, with velocity offsets of up to 2000 km s-1. Using the spectroscopic redshifts and the extensive UV-to-radio photometry in this field, we produce optimized spectral energy distributions (SEDs) using Magphys, and use the SEDs to infer a median stellar mass of {M}\\star = (6 ± 1)× 1010 M {}⊙ for our SMGs with spectroscopic redshift. By combining these stellar masses with the star formation rates (measured from the far-infrared SEDs), we show that SMGs (on average) lie a factor of ˜5 above the so-called “main sequence” at z˜ 2. We provide this library of 52 template fits with robust and uniquely well-sampled SEDs as a resource for future studies of SMGs, and also release the spectroscopic catalog of ˜2000 (mostly infrared-selected) galaxies targeted as part of the spectroscopic campaign.

Spectroscopic properties of nuclear skyrme energy density functionals.

PubMed

Tarpanov, D; Dobaczewski, J; Toivanen, J; Carlsson, B G

2014-12-19

We address the question of how to improve the agreement between theoretical nuclear single-particle energies (SPEs) and observations. Empirically, in doubly magic nuclei, the SPEs can be deduced from spectroscopic properties of odd nuclei that have one more or one less neutron or proton. Theoretically, bare SPEs, before being confronted with observations, must be corrected for the effects of the particle vibration coupling (PVC). In the present work, we determine the PVC corrections in a fully self-consistent way. Then, we adjust the SPEs, with PVC corrections included, to empirical data. In this way, the agreement with observations, on average, improves; nevertheless, large discrepancies still remain. We conclude that the main source of disagreement is still in the underlying mean fields, and not in including or neglecting the PVC corrections.

Near-infrared Spectroscopic Observations of Comet C/2013 R1 (Lovejoy) by WINERED: CN Red-system Band Emission

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shinnaka, Yoshiharu; Yasui, Chikako; Izumi, Natsuko

Although high-resolution spectra of the CN red-system band are considered useful in cometary sciences, e.g., in the study of isotopic ratios of carbon and nitrogen in cometary volatiles, there have been few reports to date due to the lack of high-resolution ( R  ≡  λ /Δ λ  > 20,000) spectrographs in the near-infrared region around ∼1 μ m. Here, we present the high-resolution emission spectrum of the CN red-system band in comet C/2013 R1 (Lovejoy), acquired by the near-infrared high-resolution spectrograph WINERED mounted on the 1.3 m Araki telescope at the Koyama Astronomical Observatory, Kyoto, Japan. We applied our fluorescence excitation models for CN, based onmore » modern spectroscopic studies, to the observed spectrum of comet C/2013 R1 (Lovejoy) to search for CN isotopologues ({sup 13}C{sup 14}N and {sup 12}C{sup 15}N). We used a CN fluorescence excitation model involving both a “pure” fluorescence excitation model for the outer coma and a “fully collisional” fluorescence excitation model for the inner coma region. Our emission model could reproduce the observed {sup 12}C{sup 14}N red-system band of comet C/2013 R1 (Lovejoy). The derived mixing ratio between the two excitation models was 0.94(+0.02/−0.03):0.06(+0.03/−0.02), corresponding to the radius of the collision-dominant region of ∼800–1600 km from the nucleus. No isotopologues were detected. The observed spectrum is consistent, within error, with previous estimates in comets of {sup 12}C/{sup 13}C (∼90) and {sup 14}N/{sup 15}N (∼150).« less

The Challenges and Benefits of Employing a Mobile Research Fellow to Facilitate Team Work on a Large, Interdisciplinary, Multi-Sited Project

ERIC Educational Resources Information Center

Sugden, Fraser; Punch, Samantha

2014-01-01

Over the last few years research funding has increasingly moved in favour of large, multi-partner, interdisciplinary and multi-site research projects. This article explores the benefits and challenges of employing a full-time research fellow to work across multiple field sites, with all the local research teams, on an international,…

Multisite Parent-Centered Risk Assessment to Reduce Pediatric Oral Chemotherapy Errors

PubMed Central

Walsh, Kathleen E.; Mazor, Kathleen M.; Roblin, Douglas; Biggins, Colleen; Wagner, Joann L.; Houlahan, Kathleen; Li, Justin W.; Keuker, Christopher; Wasilewski-Masker, Karen; Donovan, Jennifer; Kanaan, Abir; Weingart, Saul N.

2013-01-01

Purpose: Observational studies describe high rates of errors in home oral chemotherapy use in children. In hospitals, proactive risk assessment methods help front-line health care workers develop error prevention strategies. Our objective was to engage parents of children with cancer in a multisite study using proactive risk assessment methods to identify how errors occur at home and propose risk reduction strategies. Methods: We recruited parents from three outpatient pediatric oncology clinics in the northeast and southeast United States to participate in failure mode and effects analyses (FMEA). An FMEA is a systematic team-based proactive risk assessment approach in understanding ways a process can fail and develop prevention strategies. Steps included diagram the process, brainstorm and prioritize failure modes (places where things go wrong), and propose risk reduction strategies. We focused on home oral chemotherapy administration after a change in dose because prior studies identified this area as high risk. Results: Parent teams consisted of four parents at two of the sites and 10 at the third. Parents developed a 13-step process map, with two to 19 failure modes per step. The highest priority failure modes included miscommunication when receiving instructions from the clinician (caused by conflicting instructions or parent lapses) and unsafe chemotherapy handling at home. Recommended risk assessment strategies included novel uses of technology to improve parent access to information, clinicians, and other parents while at home. Conclusion: Parents of pediatric oncology patients readily participated in a proactive risk assessment method, identifying processes that pose a risk for medication errors involving home oral chemotherapy. PMID:23633976

The importance of the verbal shift handover report: a multi-site case study.

PubMed

Randell, Rebecca; Wilson, Stephanie; Woodward, Peter

2011-11-01

Shift handover is seen as a key tool in ensuring continuity of care yet a number of studies have highlighted the role of shift handovers in adverse events. This, combined with the increased frequency of shift handovers, has led to interest in providing technological support for handover to enhance safety. The aim of this paper is to describe current practices for the conduct of shift handovers and to use this as a basis for considering the role that technology could play in supporting handover. A multi-site case study of handover was conducted. Data included observations of 15 medical shift handovers and 33 nursing shift handovers across three case sites. The findings highlight the way in which the verbal shift handover report is practically focused, displaying the healthcare professional's ability to know what information is required and where further explanation is needed. As well as supporting teaching and team cohesion, shift handover can provide an opportunity to reflect on the previous shift and for discussion with patients and their families. The benefits provided by a face to face handover suggest that technology should focus on supporting rather than replacing the verbal shift handover report, providing a flexible solution that allows handover participants to gather more information as it is required. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

HERSCHEL SPECTROSCOPIC OBSERVATIONS OF LITTLE THINGS DWARF GALAXIES

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cigan, Phil; Young, Lisa; Cormier, Diane

We present far-infrared (FIR) spectral line observations of five galaxies from the Little Things sample: DDO 69, DDO 70, DDO 75, DDO 155, and WLM. While most studies of dwarfs focus on bright systems or starbursts due to observational constraints, our data extend the observed parameter space into the regime of low surface brightness dwarf galaxies with low metallicities and moderate star formation rates. Our targets were observed with Herschel at the [C ii] 158 μm, [O i] 63 μm, [O iii] 88 μm, and [N ii] 122 μm emission lines using the PACS Spectrometer. These high-resolution maps allow usmore » for the first time to study the FIR properties of these systems on the scales of larger star-forming complexes. The spatial resolution in our maps, in combination with star formation tracers, allows us to identify separate photodissociation regions (PDRs) in some of the regions we observed. Our systems have widespread [C ii] emission that is bright relative to continuum, averaging near 0.5% of the total infrared (TIR) budget—higher than in solar-metallicity galaxies of other types. [N ii] is weak, suggesting that the [C ii] emission in our galaxies comes mostly from PDRs instead of the diffuse ionized interstellar medium (ISM). These systems exhibit efficient cooling at low dust temperatures, as shown by ([O i]+[C ii])/TIR in relation to 60 μm/100 μm, and low [O i]/[C ii] ratios which indicate that [C ii] is the dominant coolant of the ISM. We observe [O iii]/[C ii] ratios in our galaxies that are lower than those published for other dwarfs, but similar to levels noted in spirals.« less

Multi-Site Diagnostic Classification of Schizophrenia Using Discriminant Deep Learning with Functional Connectivity MRI.

PubMed

Zeng, Ling-Li; Wang, Huaning; Hu, Panpan; Yang, Bo; Pu, Weidan; Shen, Hui; Chen, Xingui; Liu, Zhening; Yin, Hong; Tan, Qingrong; Wang, Kai; Hu, Dewen

2018-04-01

A lack of a sufficiently large sample at single sites causes poor generalizability in automatic diagnosis classification of heterogeneous psychiatric disorders such as schizophrenia based on brain imaging scans. Advanced deep learning methods may be capable of learning subtle hidden patterns from high dimensional imaging data, overcome potential site-related variation, and achieve reproducible cross-site classification. However, deep learning-based cross-site transfer classification, despite less imaging site-specificity and more generalizability of diagnostic models, has not been investigated in schizophrenia. A large multi-site functional MRI sample (n = 734, including 357 schizophrenic patients from seven imaging resources) was collected, and a deep discriminant autoencoder network, aimed at learning imaging site-shared functional connectivity features, was developed to discriminate schizophrenic individuals from healthy controls. Accuracies of approximately 85·0% and 81·0% were obtained in multi-site pooling classification and leave-site-out transfer classification, respectively. The learned functional connectivity features revealed dysregulation of the cortical-striatal-cerebellar circuit in schizophrenia, and the most discriminating functional connections were primarily located within and across the default, salience, and control networks. The findings imply that dysfunctional integration of the cortical-striatal-cerebellar circuit across the default, salience, and control networks may play an important role in the "disconnectivity" model underlying the pathophysiology of schizophrenia. The proposed discriminant deep learning method may be capable of learning reliable connectome patterns and help in understanding the pathophysiology and achieving accurate prediction of schizophrenia across multiple independent imaging sites. Copyright © 2018 German Center for Neurodegenerative Diseases (DZNE). Published by Elsevier B.V. All rights reserved.

Overcoming the Challenges of Unstructured Data in Multi-site, Electronic Medical Record-based Abstraction

PubMed Central

Polnaszek, Brock; Gilmore-Bykovskyi, Andrea; Hovanes, Melissa; Roiland, Rachel; Ferguson, Patrick; Brown, Roger; Kind, Amy JH

2014-01-01

Background Unstructured data encountered during retrospective electronic medical record (EMR) abstraction has routinely been identified as challenging to reliably abstract, as this data is often recorded as free text, without limitations to format or structure. There is increased interest in reliably abstracting this type of data given its prominent role in care coordination and communication, yet limited methodological guidance exists. Objective As standard abstraction approaches resulted in sub-standard data reliability for unstructured data elements collected as part of a multi-site, retrospective EMR study of hospital discharge communication quality, our goal was to develop, apply and examine the utility of a phase-based approach to reliably abstract unstructured data. This approach is examined using the specific example of discharge communication for warfarin management. Research Design We adopted a “fit-for-use” framework to guide the development and evaluation of abstraction methods using a four step, phase-based approach including (1) team building, (2) identification of challenges, (3) adaptation of abstraction methods, and (4) systematic data quality monitoring. Measures Unstructured data elements were the focus of this study, including elements communicating steps in warfarin management (e.g., warfarin initiation) and medical follow-up (e.g., timeframe for follow-up). Results After implementation of the phase-based approach, inter-rater reliability for all unstructured data elements demonstrated kappas of ≥ 0.89 -- an average increase of + 0.25 for each unstructured data element. Conclusions As compared to standard abstraction methodologies, this phase-based approach was more time intensive, but did markedly increase abstraction reliability for unstructured data elements within multi-site EMR documentation. PMID:27624585

Issues in the design of multisite clinical trials of psychotherapy: VA Cooperative Study No. 494 as an example.

PubMed

Schnurr, Paula P; Friedman, Matthew J; Engel, Charles C; Foa, Edna B; Shea, M Tracie; Resick, Patricia M; James, Kenneth E; Chow, Bruce K

2005-12-01

This article describes issues in the design of an ongoing multisite randomized clinical trial of psychotherapy for treating posttraumatic stress disorder (PTSD) in female veterans and active duty personnel. Research aimed at testing treatments for PTSD in women who have served in the military is especially important due to the high prevalence of PTSD in this population. VA Cooperative Study 494 was designed to enroll 384 participants across 12 sites. Participants are randomly assigned to receive 10 weekly sessions of individual psychotherapy: Prolonged Exposure, a specific cognitive-behavioral therapy protocol for PTSD, or present-centered therapy, a comparison treatment that addresses current interpersonal problems but avoids a trauma focus. PTSD is the primary outcome. Additional outcomes are comorbid problems such as depression and anxiety; psychosocial function and quality of life; physical health status; satisfaction with treatment; and service utilization. Follow-up assessments are conducted at the end of treatment and then 3 and 6 months after treatment. Both treatments are delivered according to a manual. Videotapes of therapy sessions are viewed by experts who provide feedback to therapists throughout the trial to ensure adherence to the treatment manual. Discussion includes issues encountered in multisite psychotherapy trials along with the rationale for our decisions about how we addressed these issues in CSP #494.

The Setting-up of Multi-Site School Collaboratives: The Benefits of This Organizational Reform in Terms of Networking Opportunities and Their Effects

ERIC Educational Resources Information Center

Mifsud, Denise

2015-01-01

This article, which is set within the Maltese education scenario of unfolding decentralization through the setting-up of multi-site school collaboratives (legally termed "colleges") via a policy mandate, explores a particular aspect of this reform--that of "networking". This is examined in terms of the potential for…

The double-lined spectroscopic binary Iota Pegasi

NASA Technical Reports Server (NTRS)

Fekel, F. C.; Tomkin, J.

1983-01-01

Reticon observations of the spectroscopic binary Iota Peg at 6430 A show the secondary star's weak, but well defined lines. Determinations have accordingly been made of the secondary velocity curve as well as that of the primary, together with the orbits and the minimum masses of the two components. The 1.31 + or - 0.02 and 0.81 + or - 0.01 solar mass minimum masses are sufficiently close to the expected actual masses to suggest eclipses, despite the relatively long, 10.2-day period. The spectral type of the secondary is estimated to be G8 V.

The Benefits and Challenges of Preconsent in a Multisite, Pediatric Sickle Cell Intervention Trial.

PubMed

Nimmer, Mark; Czachor, Jason; Turner, Laura; Thomas, Bobbe; Woodford, Ashley L; Carpenter, Karli; Gonzalez, Victor; Liem, Robert I; Ellison, Angela; Casper, T Charles; Brousseau, David C

2016-09-01

Enrollment of patients in sickle cell intervention trials has been challenging due to difficulty in obtaining consent from a legal guardian and lack of collaboration between emergency medicine and hematology. We utilized education and preconsent in a pediatric multisite sickle cell intervention trial to overcome these challenges. Overall, 48 patients were enrolled after being preconsented. Variable Institutional Review Board policies related to preconsent validity and its allowable duration decreased the advantages of preconsent at some sites. The utility of preconsent for future intervention trials largely depends on local Institutional Review Board policies. Preeducation may also benefit the consent process, regardless of site differences. © 2016 Wiley Periodicals, Inc.

Interracial Contact and Racial Constancy: A Multi-Site Study of Racial Intergroup Bias in 3-5 Year Old Anglo-British Children

ERIC Educational Resources Information Center

Rutland, Adam; Cameron, Lindsey; Bennett, Laura; Ferrell, Jennifer

2005-01-01

This paper examined the influence of interracial contact and racial constancy on the racial intergroup bias of young Anglo-British children. This multi-site study was conducted in areas of Great Britain that varied in terms of racial diversity. The study also investigated whether preschool children express bias on positive, but not negative,…

Spectroscopic evidence for the origin of the dumbbell cyclic voltammogram of single-walled carbon nanotubes.

PubMed

Al-zubaidi, Ayar; Ishii, Yosuke; Yamada, Saki; Matsushita, Tomohiro; Kawasaki, Shinji

2013-12-21

We investigated the changes in charge carrier density responsible for the dumbbell-like cyclic voltammogram of single-walled carbon nanotubes (SWCNTs) used as electric double layer capacitor electrodes. We utilized in situ Raman spectroscopy of SWCNTs in the potential range where the dumbbell voltammogram is observed and electric double layer charging would be the dominant mechanism. The study revealed that, unexpectedly, the spectroscopic changes coinciding with the dumbbell steps on the voltammogram occur more sharply in metallic tubes, as seen from (1) the sudden enhancement in the intensity of the BWF Breit-Wigner-Fano (BWF) feature, (2) a considerably more significant frequency upshift of G(+) and G' bands, and (3) a drop in radial breathing mode intensity, compared to those in the spectra of semiconducting tubes. In addition, the spectroscopic changes observed with open-end SWCNT samples were more defined and correlated more accurately with the electronic structure of the tubes compared to those observed with closed-end SWCNTs.

Spectroscopic observations of ASASSN-17io and ATLAS17hpt (SN 2017faf) by NUTS (NOT Un-biased Transient Survey)

NASA Astrophysics Data System (ADS)

Pastorello, Andrea; Benetti, Stefano; Cappellaro, Enrico; Terreran, Giacomo; Tomasella, Lina; Fedorets, Grigori; NUTS Collaboration

2017-07-01

The Nordic Optical Telescope (NOT) Unbiased Transient Survey (NUTS; ATel #8992) reports the spectroscopic classification of ASASSN-17io in the galaxy CGCG 316-010, along with the re classification of ATLAS17hpt (SN 2017faf), which was previously classified as a SLSN-I (ATel #10549).

Spectroscopic parallaxes of MAP region stars from UBVRI, DDO, and uvbyH-beta photometry. [Multichannel Astrometric Photometer for astronomical observation

NASA Technical Reports Server (NTRS)

Persinger, Tim; Castelaz, Michael W.

1990-01-01

This paper presents the results of spectral type and luminosity classification of reference stars in the Allegheny Observatory MAP parallax program, using broadband and intermediate-band photometry. In addition to the use of UBVRI and DDO photometric systems, the uvbyH-beta photometric system was included for classification of blue (B - V less than 0.6) reference stars. The stellar classifications made from the photometry are used to determine spectroscopic parallaxes. The spectroscopic parallaxes are used in turn to adjust the relative parallaxes measured with the MAP to absolute parallaxes. A new method for dereddening stars using more than one photometric system is presented. In the process of dereddening, visual extinctions, spectral types, and luminosity classes are determined, as well as a measure of the goodness of fit. The measure of goodness of fit quantifies confidence in the stellar classifications. It is found that the spectral types are reliable to within 2.5 spectral subclasses.

The Tarantula Massive Binary Monitoring. I. Observational campaign and OB-type spectroscopic binaries

NASA Astrophysics Data System (ADS)

Almeida, L. A.; Sana, H.; Taylor, W.; Barbá, R.; Bonanos, A. Z.; Crowther, P.; Damineli, A.; de Koter, A.; de Mink, S. E.; Evans, C. J.; Gieles, M.; Grin, N. J.; Hénault-Brunet, V.; Langer, N.; Lennon, D.; Lockwood, S.; Maíz Apellániz, J.; Moffat, A. F. J.; Neijssel, C.; Norman, C.; Ramírez-Agudelo, O. H.; Richardson, N. D.; Schootemeijer, A.; Shenar, T.; Soszyński, I.; Tramper, F.; Vink, J. S.

2017-02-01

Context. Massive binaries play a crucial role in the Universe. Knowing the distributions of their orbital parameters is important for a wide range of topics from stellar feedback to binary evolution channels and from the distribution of supernova types to gravitational wave progenitors, yet no direct measurements exist outside the Milky Way. Aims: The Tarantula Massive Binary Monitoring project was designed to help fill this gap by obtaining multi-epoch radial velocity (RV) monitoring of 102 massive binaries in the 30 Doradus region. Methods: In this paper we analyze 32 FLAMES/GIRAFFE observations of 93 O- and 7 B-type binaries. We performed a Fourier analysis and obtained orbital solutions for 82 systems: 51 single-lined (SB1) and 31 double-lined (SB2) spectroscopic binaries. Results: Overall, the binary fraction and orbital properties across the 30 Doradus region are found to be similar to existing Galactic samples. This indicates that within these domains environmental effects are of second order in shaping the properties of massive binary systems. A small difference is found in the distribution of orbital periods, which is slightly flatter (in log space) in 30 Doradus than in the Galaxy, although this may be compatible within error estimates and differences in the fitting methodology. Also, orbital periods in 30 Doradus can be as short as 1.1 d, somewhat shorter than seen in Galactic samples. Equal mass binaries (q> 0.95) in 30 Doradus are all found outside NGC 2070, the central association that surrounds R136a, the very young and massive cluster at 30 Doradus's core. Most of the differences, albeit small, are compatible with expectations from binary evolution. One outstanding exception, however, is the fact that earlier spectral types (O2-O7) tend to have shorter orbital periods than later spectral types (O9.2-O9.7). Conclusions: Our results point to a relative universality of the incidence rate of massive binaries and their orbital properties in the

African American Veterans Storytelling: A Multisite Randomized Trial to Improve Hypertension.

PubMed

Houston, Thomas K; Fix, Gemmae M; Shimada, Stephanie L; Long, Judith A; Gordon, Howard S; Pope, Charlene; Volkman, Julie; Allison, Jeroan J; DeLaughter, Kathryn; Orner, Michelle; Bokhour, Barbara G

2017-09-01

Disparities in hypertension control persist for African American Veterans. To enhance cultural relevance of hypertension control self-management education, in a multisite, stratified randomized trial, we tested an interactive Veteran-to-Veteran storytelling digital video disk (DVD) intervention created with Veteran partners, versus an education-only DVD comparison. At 3 VA facilities, African American Veterans with uncontrolled hypertension were randomized to storytelling DVD intervention or didactic comparison DVD and followed for 6 months. We hypothesized that follow-up blood pressure (BP) would be lower among Veterans in the intervention group. African American Veterans (N=619) were 92% male, 39% over age 65, most had a high-school education, over 50% of both the intervention and comparison group reported a household income of <$20,000, and 40% had less than adequate health literacy. At baseline, mean intervention and comparison group BPs were 138/80 and 139/81 mm Hg, respectively; at 6 months, mean systolic BP (SBP) increased by 0.1 in the intervention group and by 1.9 for the comparison group; diastolic BP fell by 0.1 in the intervention group and rose by 0.2 in the comparison group. No differences between the intervention and control groups were statistically significant (all P>0.3). Site differences were large; at one, the intervention group improved while the comparison groups deteriorated, resulting in 6.3 and 3.9 mm Hg more improvement for the intervention group in SBP and diastolic BP (P=0.06 and 0.04), respectively; at the other 2 sites, there were positive and negative changes, all small, in the 2 measures, with minimal differences-one site favored the comparison group and the other, the intervention (these comparisons did not approach statistical significance (all P>0.20). In a secondary analysis stratified by baseline BP, there was no intervention effect among those with uncontrolled BP, but intervention patients who were in control at baseline were

Pre-phase A: Development of a far-ultraviolet photometric- and spectroscopic-survey small-explorer experiment

NASA Technical Reports Server (NTRS)

Martin, Christopher

1993-01-01

We propose to perform a far ultraviolet photometric and spectroscopic survey covering the lambda lambda 1300-2000 band with a sensitivity comparable to that of the Palomar Sky Survey. This survey will proceed in three phases: an all-sky survey in three bands to 18-19.5(sup m), deep surveys of selected targets of interest in the same bands to 21-22(sup m), and a spectroscopic survey of 2 percent of the sky to 18(sup m) with a resolution of 3-20A. This mission, the Joint Ultraviolet Nightsky Observer (JUNO), can be performed by a Small-Explorer-class satellite.

Spectroscopic studies of GTA welding plasmas. Temperature calculation and dilution measurement

NASA Astrophysics Data System (ADS)

Lacroix, D.; Boudot, C.; Jeandel, G.

1999-10-01

A spectroscopic study of the GTAW plasma-plume created during the welding of stainless steel and other materials (iron, nickel and chromium) has been carried out. The spectra of these plasmas have been studied for several welding parameters. Temperature calculations are based on the observation of relative intensities and shapes of the emission peaks. We assume that the plasma is in local thermal equilibrium. The temperature is calculated with the Boltzmann plot method from twelve iron emission lines (in the range 368 385 nm): it varies between 9650 and 12 100 K. Dilution experiments have been carried out. We checked the mixing of metals: during welding of two different metallic plates and during welding with an Inconel wire. Dilution is monitored following the intensity of some characteristic emission lines (chromium and nickel). Comparison of spectroscopic results and metallographic ones is made.

On the relative frequencies of spectroscopically normal and peculiar type Ia supernovae

NASA Technical Reports Server (NTRS)

Branch, David; Fisher, Adam; Nugent, Peter

1993-01-01

After defining what we mean by spectroscopically 'normal' and 'peculiar' Type Ia supernove, we report the results of an attempt to subclassify 84 SNe Ia either as normal or as like one of the recent, peculiar SNe Ia: 1991T, 1991bg, or 1986G. Only SNe 1957A and 1960H are found to have been certifiably abnormal, with SN 1957A; appearing to have been like SN 1991bg, and SN 1960H having been like SN 1991bg or SN 1988G; SNe 1971I and 1980I are under suspicion of having been like SN 1986G, and SN 1988G of having been like SN 1991T. Of the SNe Ia we have been able to classify either as normal or as peculiar, 89% (or 83%, counting those under suspicion as peculiar) are normal. Our main conclusion is that the observational sample of SNe Ia is strongly peaked at 'spectroscopically normal.' We further conclude that when arranged in the photometric sequence of Phillips (1993) SNe Ia also form a spectroscopic sequence, and that peculiar SNe Ia are over-represented in the Phillips sample.

Handbook of Basic Atomic Spectroscopic Data

National Institute of Standards and Technology Data Gateway

SRD 108 Handbook of Basic Atomic Spectroscopic Data (Web, free access)   This handbook provides a selection of the most important and frequently used atomic spectroscopic data. The compilation includes data for the neutral and singly-ionized atoms of all elements hydrogen through einsteinium (Z = 1-99). The wavelengths, intensities, and spectrum assignments are given for each element, and the data for the approximately 12,000 lines of all elements are also collected into a single table.

Spectroscopic Characterization of GEO Satellites with Gunma LOW Resolution Spectrograph

NASA Astrophysics Data System (ADS)

Endo, T.; Ono, H.; Hosokawa, M.; Ando, T.; Takanezawa, T.; Hashimoto, O.

The spectroscopic observation is potentially a powerful tool for understanding the Geostationary Earth Orbit (GEO) objects. We present here the results of an investigation of energy spectra of GEO satellites obtained from a groundbased optical telescope. The spectroscopic observations were made from April to June 2016 with the Gunma LOW resolution Spectrograph and imager (GLOWS) at the Gunma Astronomical Observatory (GAO) in JAPAN. The observation targets consist of eleven different satellites: two weather satellites, four communications satellites, and five broadcasting satellites. All the spectra of those GEO satellites are inferred to be solar-like. A number of well-known absorption features such as H-alpha, H-beta, Na-D,water vapor and oxygen molecules are clearly seen in thewavelength range of 4,000 - 8,000 Å. For comparison, we calculated the intensity ratio of the spectra of GEO satellites to that of the Moon which is the natural satellite of the earth. As a result, the following characteristics were obtained. 1) Some variations are seen in the strength of absorption features of water vapor and oxygen originated by the telluric atmosphere, but any other characteristic absorption features were not found. 2) For all observed satellites, the intensity ratio of the spectrum of GEO satellites decrease as a function of wavelength or to be flat. It means that the spectral reflectance of satellite materials is bluer than that of the Moon. 3) A characteristic dip at around 4,800 Å is found in all observed spectra of a weather satellite. Based on these observations, it is indicated that the characteristics of the spectrum are mainly derived from the solar panels because the apparent area of the solar cell is probably larger than that of the satellite body.

Infrared spectroscopy and spectroscopic imaging in forensic science.

PubMed

Ewing, Andrew V; Kazarian, Sergei G

2017-01-16

Infrared spectroscopy and spectroscopic imaging, are robust, label free and inherently non-destructive methods with a high chemical specificity and sensitivity that are frequently employed in forensic science research and practices. This review aims to discuss the applications and recent developments of these methodologies in this field. Furthermore, the use of recently emerged Fourier transform infrared (FT-IR) spectroscopic imaging in transmission, external reflection and Attenuated Total Reflection (ATR) modes are summarised with relevance and potential for forensic science applications. This spectroscopic imaging approach provides the opportunity to obtain the chemical composition of fingermarks and information about possible contaminants deposited at a crime scene. Research that demonstrates the great potential of these techniques for analysis of fingerprint residues, explosive materials and counterfeit drugs will be reviewed. The implications of this research for the examination of different materials are considered, along with an outlook of possible future research avenues for the application of vibrational spectroscopic methods to the analysis of forensic samples.

The DEIMOS 10K Spectroscopic Survey Catalog of the COSMOS Field

NASA Astrophysics Data System (ADS)

Hasinger, G.; Capak, P.; Salvato, M.; Barger, A. J.; Cowie, L. L.; Faisst, A.; Hemmati, S.; Kakazu, Y.; Kartaltepe, J.; Masters, D.; Mobasher, B.; Nayyeri, H.; Sanders, D.; Scoville, N. Z.; Suh, H.; Steinhardt, C.; Yang, Fengwei

2018-05-01

We present a catalog of 10,718 objects in the COSMOS field, observed through multi-slit spectroscopy with the Deep Imaging Multi-Object Spectrograph (DEIMOS) on the Keck II telescope in the wavelength range ∼5500–9800 Å. The catalog contains 6617 objects with high-quality spectra (two or more spectral features), and 1798 objects with a single spectroscopic feature confirmed by the photometric redshift. For 2024 typically faint objects, we could not obtain reliable redshifts. The objects have been selected from a variety of input catalogs based on multi-wavelength observations in the field, and thus have a diverse selection function, which enables the study of the diversity in the galaxy population. The magnitude distribution of our objects is peaked at I AB ∼ 23 and K AB ∼ 21, with a secondary peak at K AB ∼ 24. We sample a broad redshift distribution in the range 0 < z < 6, with one peak at z ∼ 1, and another one around z ∼ 4. We have identified 13 redshift spikes at z > 0.65 with chance probabilities < 4 × 10‑4, some of which are clearly related to protocluster structures of sizes >10 Mpc. An object-to-object comparison with a multitude of other spectroscopic samples in the same field shows that our DEIMOS sample is among the best in terms of fraction of spectroscopic failures and relative redshift accuracy. We have determined the fraction of spectroscopic blends to about 0.8% in our sample. This is likely a lower limit and at any rate well below the most pessimistic expectations. Interestingly, we find evidence for strong lensing of Lyα background emitters within the slits of 12 of our target galaxies, increasing their apparent density by about a factor of 4. The data presented herein were obtained at the W. M. Keck Observatory, which is operated as a scientific partnership among the California Institute of Technology, the University of California and the National Aeronautics and Space Administration. The Observatory was made possible by the

Spectroscopic identification of jet-cooled p-fluoro-α-methylbenzyl radical in corona discharge

NASA Astrophysics Data System (ADS)

Lee, Gi Woo; Lee, Sang Kuk

2009-02-01

We report the first spectroscopic identification of the p-fluoro-α-methylbenzyl radical in the gas phase. Precursor p-fluoro-ethylbenzene seeded in a large amount of carrier gas was electrically discharged to produce the benzyl-type radicals in a corona excited supersonic expansion using a pinhole-type glass nozzle, from which the vibronic emission spectrum was recorded in the visible region. From an analysis of the spectrum observed, we identified spectroscopically the formation of the p-fluoro-α-methylbenzyl, in which the energy of the D 1 → D 0 electronic transition and a few vibrational mode frequencies in the ground electronic state were determined by comparison with those from an ab initio calculation and with those from the known data of the precursor.

Unveiling a novel transient druggable pocket in BACE-1 through molecular simulations: Conformational analysis and binding mode of multisite inhibitors

PubMed Central

Di Pietro, Ornella; Laughton, Charles A.

2017-01-01

The critical role of BACE-1 in the formation of neurotoxic ß-amyloid peptides in the brain makes it an attractive target for an efficacious treatment of Alzheimer’s disease. However, the development of clinically useful BACE-1 inhibitors has proven to be extremely challenging. In this study we examine the binding mode of a novel potent inhibitor (compound 1, with IC50 80 nM) designed by synergistic combination of two fragments—huprine and rhein—that individually are endowed with very low activity against BACE-1. Examination of crystal structures reveals no appropriate binding site large enough to accommodate 1. Therefore we have examined the conformational flexibility of BACE-1 through extended molecular dynamics simulations, paying attention to the highly flexible region shaped by loops 8–14, 154–169 and 307–318. The analysis of the protein dynamics, together with studies of pocket druggability, has allowed us to detect the transient formation of a secondary binding site, which contains Arg307 as a key residue for the interaction with small molecules, at the edge of the catalytic cleft. The formation of this druggable “floppy” pocket would enable the binding of multisite inhibitors targeting both catalytic and secondary sites. Molecular dynamics simulations of BACE-1 bound to huprine-rhein hybrid compounds support the feasibility of this hypothesis. The results provide a basis to explain the high inhibitory potency of the two enantiomeric forms of 1, together with the large dependence on the length of the oligomethylenic linker. Furthermore, the multisite hypothesis has allowed us to rationalize the inhibitory potency of a series of tacrine-chromene hybrid compounds, specifically regarding the apparent lack of sensitivity of the inhibition constant to the chemical modifications introduced in the chromene unit. Overall, these findings pave the way for the exploration of novel functionalities in the design of optimized BACE-1 multisite inhibitors

Multisite musculoskeletal pain in adolescence and later mental health disorders: a population-based registry study of Norwegian youth: the NAAHS cohort study

PubMed Central

Eckhoff, Christian; Straume, Bjørn; Kvernmo, Siv

2017-01-01

Objectives To examine the association between multisite musculoskeletal pain in adolescence and mental health disorders in young adulthood. Design and setting Data were obtained from a linkage between the Norwegian Patient Registry (2008–2012) and the Norwegian Arctic Adolescent Health Study, a school-based survey conducted among 10th grade students in North Norway (2003–2005). Participants In total, 3987 (68%) of all 5877 invited participants consented to the registry linkage. Outcome measures Mental healthcare use and disorders from age 18–20 to 23–25 years (5 years). Methods Musculoskeletal pain was measured by the number of musculoskeletal pain sites. Multivariable logistic regression was used to explore the association with later mental healthcare use and disorders. Results Multisite adolescent musculoskeletal pain was significantly associated with an increase in mental healthcare use and mental health disorders in young adulthood. The relationship was stronger for anxiety and mood disorders, in both genders. Overall, the association between musculoskeletal pain and later mental health problems was attenuated after controlling for adolescent psychosocial and mental health problems, not by physical or sedentary activity. This could be due to confounding or mediation. However, when examining different mental health disorders, we found musculoskeletal pain to be significantly associated with anxiety disorders, and showing a strong trend in mood disorders, when adjusted for the adolescent factors. Conclusions Physicians should be aware that multisite adolescent pain is associated with mental health problems in adolescence, and that these adolescents are at increased risk of mental health disorders in young adulthood. As youth troubled by mental health problems commonly present physical symptoms it is important to examine for psychosocial problems in order to offer early interventions. PMID:28188150

Raman Spectroscopic Observations of the Ion Association between Mg(2+) and SO4(2-) in MgSO4-Saturated Droplets at Temperatures of ≤380 °C.

PubMed

Wan, Ye; Wang, Xiaolin; Hu, Wenxuan; Chou, I-Ming

2015-08-27

Liquid–liquid phase separation was observed in aqueous MgSO4 solutions with excess H2SO4 at elevated temperatures; the aqueous MgSO4/H2SO4 solutions separated into MgSO4-rich droplets (fluid F1) and a MgSO4-poor phase (fluid F2) during heating. The phase separation temperature increases with SO4(2–)/Mg2+ ratio at a constant MgSO4 concentration. At a MgSO4/H2SO4 ratio of 5, the liquid–liquid phase separation temperature decreases with an increase in MgSO4 concentration up to ∼1.0 mol/kg and then increases at higher concentrations, showing a typical macroscale property of polymer solutions with a lower critical solution temperature (LCST) of ∼271.4 °C. In situ Raman spectroscopic analyses show that the MgSO4 concentration in fluid F1 increases with an increase in temperature, whereas that in fluid F2 decreases with an increase in temperature. In addition, HSO4(–), which does not readily form complexes with Mg(2+), tends to accumulate in fluid F2. Analyses of the v1(SO4(2–)) bands confirmed the presence of four-sulfate species of unassociated SO4(2–) (∼980 cm(–1)), contact ion pairs (CIPs; ∼995 cm(–1)), and triple ion pairs (TIPs; ∼1005 cm(–1)) in aqueous solution, and more complex ion pair chain structure (∼1020 cm(–1)) in fluid F1. Comparison of the sulfate species in fluids F1 and F2 at 280 °C suggests that SO4(2–) in fluid F2 is less associated with Mg(2+). On the basis of in situ visual and Raman spectroscopic observations, we suggest that the formation of the complex Mg(2+)–SO4(2–) ion association might be responsible for the liquid–liquid phase separation. In addition, Raman spectroscopic analyses of the OH stretching bands indicate that the hydrogen bonding in fluid F1 is stronger than that in fluid F2, which might be ascribed to the increasing probability of collision of H2O with Mg(2+) and SO4(2–) in fluid F1.

VizieR Online Data Catalog: ABCG209 spectroscopic and photometric catalog (Mercurio+, 2008)

NASA Astrophysics Data System (ADS)

Mercurio, A.; Barbera, F. L.; Haines, C. P.; Merluzzi, P.; Busarello, G.; Capaccioli, M.

2008-11-01

Spectroscopic observations were carried out at the ESO New Technology Telescope (NTT) with the ESO Multi-Mode Instrument (EMMI) and at the Telescopio Nazionale Galileo (TNG) with the Device Optimized for the LOw RESolution (DOLORES), while NIR photometric data were collected with the Son OF ISAAC (SOFI) at NTT. (3 data files).

A Meta-Analysis and Multisite Time-Series Analysis of the Differential Toxicity of Major Fine Particulate Matter Constituents

PubMed Central

Levy, Jonathan I.; Diez, David; Dou, Yiping; Barr, Christopher D.; Dominici, Francesca

2012-01-01

Health risk assessments of particulate matter less than 2.5 μm in diameter (PM2.5) often assume that all constituents of PM2.5 are equally toxic. While investigators in previous epidemiologic studies have evaluated health risks from various PM2.5 constituents, few have conducted the analyses needed to directly inform risk assessments. In this study, the authors performed a literature review and conducted a multisite time-series analysis of hospital admissions and exposure to PM2.5 constituents (elemental carbon, organic carbon matter, sulfate, and nitrate) in a population of 12 million US Medicare enrollees for the period 2000–2008. The literature review illustrated a general lack of multiconstituent models or insight about probabilities of differential impacts per unit of concentration change. Consistent with previous results, the multisite time-series analysis found statistically significant associations between short-term changes in elemental carbon and cardiovascular hospital admissions. Posterior probabilities from multiconstituent models provided evidence that some individual constituents were more toxic than others, and posterior parameter estimates coupled with correlations among these estimates provided necessary information for risk assessment. Ratios of constituent toxicities, commonly used in risk assessment to describe differential toxicity, were extremely uncertain for all comparisons. These analyses emphasize the subtlety of the statistical techniques and epidemiologic studies necessary to inform risk assessments of particle constituents. PMID:22510275

WWC Review of the Report "Transfer Incentives for High-Performing Teachers: Final Results from a Multisite Randomized Experiment." What Works Clearinghouse Single Study Review

ERIC Educational Resources Information Center

What Works Clearinghouse, 2015

2015-01-01

For the 2013 study, "Transfer Incentives for High-Performing Teachers: Final Results from a Multisite Randomized Experiment," researchers examined the impact of the Talent Transfer Initiative (TTI) on students' reading and mathematics achievement in 10 school districts. The TTI enabled principals of low-performing schools to provide…

Absolute magnitude calibration using trigonometric parallax - Incomplete, spectroscopic samples

NASA Technical Reports Server (NTRS)

Ratnatunga, Kavan U.; Casertano, Stefano

1991-01-01

A new numerical algorithm is used to calibrate the absolute magnitude of spectroscopically selected stars from their observed trigonometric parallax. This procedure, based on maximum-likelihood estimation, can retrieve unbiased estimates of the intrinsic absolute magnitude and its dispersion even from incomplete samples suffering from selection biases in apparent magnitude and color. It can also make full use of low accuracy and negative parallaxes and incorporate censorship on reported parallax values. Accurate error estimates are derived for each of the fitted parameters. The algorithm allows an a posteriori check of whether the fitted model gives a good representation of the observations. The procedure is described in general and applied to both real and simulated data.

A multisite validation of whole slide imaging for primary diagnosis using standardized data collection and analysis.

PubMed

Wack, Katy; Drogowski, Laura; Treloar, Murray; Evans, Andrew; Ho, Jonhan; Parwani, Anil; Montalto, Michael C

2016-01-01

Text-based reporting and manual arbitration for whole slide imaging (WSI) validation studies are labor intensive and do not allow for consistent, scalable, and repeatable data collection or analysis. The objective of this study was to establish a method of data capture and analysis using standardized codified checklists and predetermined synoptic discordance tables and to use these methods in a pilot multisite validation study. Fifteen case report form checklists were generated from the College of American Pathology cancer protocols. Prior to data collection, all hypothetical pairwise comparisons were generated, and a level of harm was determined for each possible discordance. Four sites with four pathologists each generated 264 independent reads of 33 cases. Preestablished discordance tables were applied to determine site by site and pooled accuracy, intrareader/intramodality, and interreader intramodality error rates. Over 10,000 hypothetical pairwise comparisons were evaluated and assigned harm in discordance tables. The average difference in error rates between WSI and glass, as compared to ground truth, was 0.75% with a lower bound of 3.23% (95% confidence interval). Major discordances occurred on challenging cases, regardless of modality. The average inter-reader agreement across sites for glass was 76.5% (weighted kappa of 0.68) and for digital it was 79.1% (weighted kappa of 0.72). These results demonstrate the feasibility and utility of employing standardized synoptic checklists and predetermined discordance tables to gather consistent, comprehensive diagnostic data for WSI validation studies. This method of data capture and analysis can be applied in large-scale multisite WSI validations.

Nanoantenna-Enhanced Infrared Spectroscopic Chemical Imaging.

PubMed

Kühner, Lucca; Hentschel, Mario; Zschieschang, Ute; Klauk, Hagen; Vogt, Jochen; Huck, Christian; Giessen, Harald; Neubrech, Frank

2017-05-26

Spectroscopic infrared chemical imaging is ideally suited for label-free and spatially resolved characterization of molecular species, but often suffers from low infrared absorption cross sections. Here, we overcome this limitation by utilizing confined electromagnetic near-fields of resonantly excited plasmonic nanoantennas, which enhance the molecular absorption by orders of magnitude. In the experiments, we evaporate microstructured chemical patterns of C 60 and pentacene with nanometer thickness on top of homogeneous arrays of tailored nanoantennas. Broadband mid-infrared spectra containing plasmonic and vibrational information were acquired with diffraction-limited resolution using a two-dimensional focal plane array detector. Evaluating the enhanced infrared absorption at the respective frequencies, spatially resolved chemical images were obtained. In these chemical images, the microstructured chemical patterns are only visible if nanoantennas are used. This confirms the superior performance of our approach over conventional spectroscopic infrared imaging. In addition to the improved sensitivity, our technique provides chemical selectivity, which would not be available with plasmonic imaging that is based on refractive index sensing. To extend the accessible spectral bandwidth of nanoantenna-enhanced spectroscopic imaging, we employed nanostructures with dual-band resonances, providing broadband plasmonic enhancement and sensitivity. Our results demonstrate the potential of nanoantenna-enhanced spectroscopic infrared chemical imaging for spatially resolved characterization of organic layers with thicknesses of several nanometers. This is of potential interest for medical applications which are currently hampered by state-of-art infrared techniques, e.g., for distinguishing cancerous from healthy tissues.

Experimental 64Zn(d⃗,t)63Zn spectroscopic factors: Guidance for isospin-symmetry-breaking calculations

NASA Astrophysics Data System (ADS)

Leach, K. G.; Garrett, P. E.; Towner, I. S.; Ball, G. C.; Bildstein, V.; Brown, B. A.; Demand, G. A.; Faestermann, T.; Finlay, P.; Green, K. L.; Hertenberger, R.; Krücken, R.; Phillips, A. A.; Rand, E. T.; Sumithrarachchi, C. S.; Svensson, C. E.; Triambak, S.; Wirth, H.-F.; Wong, J.

2013-06-01

With the recent inclusion of core orbitals to the radial-overlap component of the isospin-symmetry-breaking (ISB) corrections for superallowed Fermi β decay, experimental data are needed to test the validity of the theoretical model. This work reports measurements of single-neutron pickup reaction spectroscopic factors into 63Zn, one neutron away from 62Zn, the superallowed daughter of 62Ga. The experiment was performed using a 22-MeV polarized deuteron beam, a Q3D magnetic spectrograph, and a cathode-strip focal-plane detector to analyze outgoing tritons at nine angles between 10∘ and 60∘. Angular distributions and vector analyzing powers were obtained for all 162 observed states in 63Zn, including 125 newly observed levels, up to an excitation energy of 4.8 MeV. Spectroscopic factors are extracted and compared to several shell-model predictions, and implications for the ISB calculations are discussed.

Ground-based search for the brightest transiting planets with the Multi-site All-Sky CAmeRA: MASCARA

NASA Astrophysics Data System (ADS)

Snellen, Ignas A. G.; Stuik, Remko; Navarro, Ramon; Bettonvil, Felix; Kenworthy, Matthew; de Mooij, Ernst; Otten, Gilles; ter Horst, Rik; le Poole, Rudolf

2012-09-01

The Multi-site All-sky CAmeRA MASCARA is an instrument concept consisting of several stations across the globe, with each station containing a battery of low-cost cameras to monitor the near-entire sky at each location. Once all stations have been installed, MASCARA will be able to provide a nearly 24-hr coverage of the complete dark sky, down to magnitude 8, at sub-minute cadence. Its purpose is to find the brightest transiting exoplanet systems, expected in the V=4-8 magnitude range - currently not probed by space- or ground-based surveys. The bright/nearby transiting planet systems, which MASCARA will discover, will be the key targets for detailed planet atmosphere observations. We present studies on the initial design of a MASCARA station, including the camera housing, domes, and computer equipment, and on the photometric stability of low-cost cameras showing that a precision of 0.3-1% per hour can be readily achieved. We plan to roll out the first MASCARA station before the end of 2013. A 5-station MASCARA can within two years discover up to a dozen of the brightest transiting planet systems in the sky.

Spectroscopic characterization of nitroaromatic landmine signature explosives

NASA Astrophysics Data System (ADS)

Hernandez-Rivera, Samuel P.; Manrique-Bastidas, Cesar A.; Blanco, Alejandro; Primera, Oliva M.; Pacheco, Leonardo C.; Castillo-Chara, Jairo; Castro, Miguel E.; Mina, Nairmen

2004-09-01

TNT and DNT are important explosives used as base charges of landmines and other explosive devices. They are often combined with RDX in specific explosive formulations. Their detection in vapor phase as well as in soil in contact with the explosives is important in landmine detection technology. The spectroscopic signatures of nitroaromatic compounds in neat forms: crystals, droplets, and recrystallized samples were determined by Raman Microspectroscopy (RS), Fourier Transform Infrared Microscopy (FTIR) and Fiber Optics Coupled - Fourier Transform Infrared Spectroscopy (FOC-FTIR) using a grazing angle (GA) probe. TNT exhibits a series of characteristic bands: vibrational signatures, which allow its detection in soil. The spectroscopic signature of neat TNT is dominated by strong bands about 1380 and 2970 cm-1. The intensity and position of these bands were found remarkably different in soil samples spiked with TNT. The 1380 cm-1 band is split into a number of bands in that region. The 2970 cm-1 band is reduced in intensity and new bands are observed about 2880 cm-1. The results are consistent with a different chemical environment of TNT in soil as compared to neat TNT. Interactions were found to be dependent on the physical source of the explosive. In the case of DNT-sand interactions, shifts in vibrational frequencies of the explosives as well as the substrates were found.

Multisite musculoskeletal pain in adolescence as a predictor of medical and social welfare benefits in young adulthood: The Norwegian Arctic Adolescent Health Cohort Study.

PubMed

Eckhoff, C; Straume, B; Kvernmo, S

2017-11-01

Pain in adolescence is associated with mental health problems, the main reason for work disability in young adults. This study explores the relationship between multisite musculoskeletal pain in adolescence and later medical (sickness and medical rehabilitation benefits) and social welfare benefits, adjusted for sociodemographic, adolescent psychosocial and mental health problems. Data were obtained by linkage between the National Insurance Registry (2003-11) and the Norwegian Arctic Adolescent Health Study, a school-based survey in North Norway (2003-05), accepted by 3987 fifteen- to sixteen-year-olds (68% of the total population). The start of the follow-up time was July 1st of the corresponding year the participants responded to the health study. Musculoskeletal pain was measured by the number of musculoskeletal pain sites. We found a positive linear relationship between adolescent musculoskeletal pain sites and the occurrence of medical and social welfare benefits in young adulthood (p ≤ 0.001). Adolescent musculoskeletal pain was a significant predictor of sickness (p < 0.001) and social welfare benefits in females (p = 0.036), when adjusted for adolescent psychosocial and mental health problems. The most important adolescent psychosocial predictors were externalizing problems, less parental involvement and adverse life events. Adolescent multisite musculoskeletal pain was found to be an important predictor of later sickness and social welfare benefit receipt from adolescence to young adulthood. Adolescents with multisite musculoskeletal pain are at substantially increased risk of health and social difficulties into young adulthood. Identification and interventions for these adolescent problems could alleviate this risk and be a sound socioeconomic investment. © 2017 European Pain Federation - EFIC®.

Methods for using clinical laboratory test results as baseline confounders in multi-site observational database studies when missing data are expected.

PubMed

Raebel, Marsha A; Shetterly, Susan; Lu, Christine Y; Flory, James; Gagne, Joshua J; Harrell, Frank E; Haynes, Kevin; Herrinton, Lisa J; Patorno, Elisabetta; Popovic, Jennifer; Selvan, Mano; Shoaibi, Azadeh; Wang, Xingmei; Roy, Jason

2016-07-01

Our purpose was to quantify missing baseline laboratory results, assess predictors of missingness, and examine performance of missing data methods. Using the Mini-Sentinel Distributed Database from three sites, we selected three exposure-outcome scenarios with laboratory results as baseline confounders. We compared hazard ratios (HRs) or risk differences (RDs) and 95% confidence intervals (CIs) from models that omitted laboratory results, included only available results (complete cases), and included results after applying missing data methods (multiple imputation [MI] regression, MI predictive mean matching [PMM] indicator). Scenario 1 considered glucose among second-generation antipsychotic users and diabetes. Across sites, glucose was available for 27.7-58.9%. Results differed between complete case and missing data models (e.g., olanzapine: HR 0.92 [CI 0.73, 1.12] vs 1.02 [0.90, 1.16]). Across-site models employing different MI approaches provided similar HR and CI; site-specific models provided differing estimates. Scenario 2 evaluated creatinine among individuals starting high versus low dose lisinopril and hyperkalemia. Creatinine availability: 44.5-79.0%. Results differed between complete case and missing data models (e.g., HR 0.84 [CI 0.77, 0.92] vs. 0.88 [0.83, 0.94]). HR and CI were identical across MI methods. Scenario 3 examined international normalized ratio (INR) among warfarin users starting interacting versus noninteracting antimicrobials and bleeding. INR availability: 20.0-92.9%. Results differed between ignoring INR versus including INR using missing data methods (e.g., RD 0.05 [CI -0.03, 0.13] vs 0.09 [0.00, 0.18]). Indicator and PMM methods gave similar estimates. Multi-site studies must consider site variability in missing data. Different missing data methods performed similarly. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

Galaxy And Mass Assembly (GAMA): spectroscopic analysis

NASA Astrophysics Data System (ADS)

Hopkins, A. M.; Driver, S. P.; Brough, S.; Owers, M. S.; Bauer, A. E.; Gunawardhana, M. L. P.; Cluver, M. E.; Colless, M.; Foster, C.; Lara-López, M. A.; Roseboom, I.; Sharp, R.; Steele, O.; Thomas, D.; Baldry, I. K.; Brown, M. J. I.; Liske, J.; Norberg, P.; Robotham, A. S. G.; Bamford, S.; Bland-Hawthorn, J.; Drinkwater, M. J.; Loveday, J.; Meyer, M.; Peacock, J. A.; Tuffs, R.; Agius, N.; Alpaslan, M.; Andrae, E.; Cameron, E.; Cole, S.; Ching, J. H. Y.; Christodoulou, L.; Conselice, C.; Croom, S.; Cross, N. J. G.; De Propris, R.; Delhaize, J.; Dunne, L.; Eales, S.; Ellis, S.; Frenk, C. S.; Graham, Alister W.; Grootes, M. W.; Häußler, B.; Heymans, C.; Hill, D.; Hoyle, B.; Hudson, M.; Jarvis, M.; Johansson, J.; Jones, D. H.; van Kampen, E.; Kelvin, L.; Kuijken, K.; López-Sánchez, Á.; Maddox, S.; Madore, B.; Maraston, C.; McNaught-Roberts, T.; Nichol, R. C.; Oliver, S.; Parkinson, H.; Penny, S.; Phillipps, S.; Pimbblet, K. A.; Ponman, T.; Popescu, C. C.; Prescott, M.; Proctor, R.; Sadler, E. M.; Sansom, A. E.; Seibert, M.; Staveley-Smith, L.; Sutherland, W.; Taylor, E.; Van Waerbeke, L.; Vázquez-Mata, J. A.; Warren, S.; Wijesinghe, D. B.; Wild, V.; Wilkins, S.

2013-04-01

The Galaxy And Mass Assembly (GAMA) survey is a multiwavelength photometric and spectroscopic survey, using the AAOmega spectrograph on the Anglo-Australian Telescope to obtain spectra for up to ˜300 000 galaxies over 280 deg2, to a limiting magnitude of rpet < 19.8 mag. The target galaxies are distributed over 0 < z ≲ 0.5 with a median redshift of z ≈ 0.2, although the redshift distribution includes a small number of systems, primarily quasars, at higher redshifts, up to and beyond z = 1. The redshift accuracy ranges from σv ≈ 50 km s-1 to σv ≈ 100 km s-1 depending on the signal-to-noise ratio of the spectrum. Here we describe the GAMA spectroscopic reduction and analysis pipeline. We present the steps involved in taking the raw two-dimensional spectroscopic images through to flux-calibrated one-dimensional spectra. The resulting GAMA spectra cover an observed wavelength range of 3750 ≲ λ ≲ 8850 Å at a resolution of R ≈ 1300. The final flux calibration is typically accurate to 10-20 per cent, although the reliability is worse at the extreme wavelength ends, and poorer in the blue than the red. We present details of the measurement of emission and absorption features in the GAMA spectra. These measurements are characterized through a variety of quality control analyses detailing the robustness and reliability of the measurements. We illustrate the quality of the measurements with a brief exploration of elementary emission line properties of the galaxies in the GAMA sample. We demonstrate the luminosity dependence of the Balmer decrement, consistent with previously published results, and explore further how Balmer decrement varies with galaxy mass and redshift. We also investigate the mass and redshift dependencies of the [N II]/Hα versus [O III]/Hβ spectral diagnostic diagram, commonly used to discriminate between star forming and nuclear activity in galaxies.

Spectroscopic characterization of low dose rate brachytherapy sources

NASA Astrophysics Data System (ADS)

Beach, Stephen M.

The low dose rate (LDR) brachytherapy seeds employed in permanent radioactive-source implant treatments usually use one of two radionuclides, 125I or 103Pd. The theoretically expected source spectroscopic output from these sources can be obtained via Monte Carlo calculation based upon seed dimensions and materials as well as the bare-source photon emissions for that specific radionuclide. However the discrepancies resulting from inconsistent manufacturing of sources in comparison to each other within model groups and simplified Monte Carlo calculational geometries ultimately result in undesirably large uncertainties in the Monte Carlo calculated values. This dissertation describes experimentally attained spectroscopic outputs of the clinically used brachytherapy sources in air and in liquid water. Such knowledge can then be applied to characterize these sources by a more fundamental and metro logically-pure classification, that of energy-based dosimetry. The spectroscopic results contained within this dissertation can be utilized in the verification and benchmarking of Monte Carlo calculational models of these brachytherapy sources. This body of work was undertaken to establish a usable spectroscopy system and analysis methods for the meaningful study of LDR brachytherapy seeds. The development of a correction algorithm and the analysis of the resultant spectroscopic measurements are presented. The characterization of the spectrometer and the subsequent deconvolution of the measured spectrum to obtain the true spectrum free of any perturbations caused by the spectrometer itself is an important contribution of this work. The approach of spectroscopic deconvolution that was applied in this work is derived in detail and it is applied to the physical measurements. In addition, the spectroscopically based analogs to the LDR dosimetry parameters that are currently employed are detailed, as well as the development of the theory and measurement methods to arrive at these

Structural transformation of synthetic hydroxyapatite under simulated in vivo conditions studied with ATR-FTIR spectroscopic imaging

NASA Astrophysics Data System (ADS)

Sroka-Bartnicka, Anna; Borkowski, Leszek; Ginalska, Grazyna; Ślósarczyk, Anna; Kazarian, Sergei G.

2017-01-01

Hydroxyapatite and carbonate-substituted hydroxyapatite are widely used in bone tissue engineering and regenerative medicine. Both apatite materials were embedded into recently developed ceramic/polymer composites, subjected to Simulated Body Fluid (SBF) for 30 days and characterized using ATR-FTIR spectroscopic imaging to assess their behaviour and structures. The specific aim was to detect the transition phases between both types of hydroxyapatite during the test and to analyze the surface modification caused by SBF. ATR-FTIR spectroscopic imaging was successfully applied to characterise changes in the hydroxyapatite lattice due to the elastic properties of the scaffolds. It was observed that SBF treatment caused a replacement of phosphates in the lattice of non-substituted hydroxyapatite by carbonate ions. A detailed study excluded the formation of pure A type carbonate apatite. In turn, CO32- content in synthetic carbonate-substituted hydroxyapatite decreased. The usefulness of ATR-FTIR spectroscopic imaging studies in the evaluation of elastic and porous β-glucan hydroxyapatite composites has been demonstrated.

Deformation-related spectroscopic features in natural Type Ib-IaA diamonds from Zimmi (West African craton)

NASA Astrophysics Data System (ADS)

Smit, Karen V.; D'Haenens-Johansson, Ulrika F. S.; Howell, Daniel; Loudin, Lorne C.; Wang, Wuyi

2018-06-01

Zimmi diamonds (Sierra Leone) have 500 million year mantle residency times whose origin is best explained by rapid tectonic exhumation to shallower depths in the mantle, associated with continental collision but prior to kimberlite eruption. Here we present spectroscopic data for a new suite of Zimmi sulphide-bearing diamonds that allow us to evaluate the link between their spectroscopic features and their unusual geological history. Cathodoluminesence (CL) imaging of these diamonds revealed irregular patterns with abundant deformation lamellae, associated with the diamonds' tectonic exhumation. Vacancies formed during deformation were subsequently naturally annealed to form vacancy clusters, NV0/- centres and H3 (NVN0). The brownish-yellow to greenish-yellow colours observed in Zimmi Ib-IaA diamonds result from visible absorption by a combination of isolated substitutional nitrogen ( {N}S^0 ) and deformation-related vacancy clusters. Colour-forming centres and other spectroscopic features can all be attributed to the unique geological history of Zimmi Ib-IaA diamonds and their rapid exhumation after formation.

Infrared Imaging, Spectroscopic, and Photometric Studies of Comets

NASA Technical Reports Server (NTRS)

Gehrz, Robert D.

1997-01-01

We have continued our program of infrared (IR) photometric, imaging, spectroscopic, and polarimetric temporal observations of comets to study the properties of comet dust and comet nuclei. During the first two years we digitized our IR data base on P/Halley and other recent comets to facilitate further analysis and comparison with other data bases, and found compelling evidence for the emission of a burst of small grains from P/Halley's nucleus at perihelion. We reported imaging and photometric observations of Comets Austin 1990 V and Swift-Tuttle 1992. The Swift-Tuttle 1992t observations included IR photometry, several 7-14 micron long-slit spectra of the coma and a time-sequence of more than 150 10 micron broadband images of the coma. An analysis of near-IR images of the inner coma of P/Halley obtained on three consecutive nights in 1986 March showed sunwardjets. We completed our analysis of IR imaging spectrosco-photometric data on comets. We also obtained observations of Comets Hyakutake 1996 B2 and Hale/Bopp 1995 01. We obtained infrared imaging, photometric, spectroscopic and polarimetric temporal observations of bright comets using a network of five telescopes, with emphasis on simultaneous observations of comets at many wavelengths with different instruments. Our program offers several unique advantages: 1) rapid observational response to new comets with dedicated infrared telescopes; 2) observations within a few degrees of the sun when comets are near perihelion and 3) access to advanced infrared array imagers and spectrometers. In particular, reduction, analysis, publication and archiving of our Jupiter/sl-9 and Comet Hyakutake infrared data received special emphasis. Instrumentation development included installation of the latest version of the innovative FORTH telescope control and a data acquisition system that enables us to control three telescopes remotely by telephone from anywhere in the world for comet observations in broad daylight. We have

Ensuring treatment fidelity in a multi-site behavioral intervention study: implementing NIH Behavior Change Consortium recommendations in the SMART trial.

PubMed

Robb, Sheri L; Burns, Debra S; Docherty, Sharron L; Haase, Joan E

2011-11-01

The Stories and Music for Adolescent/Young Adult Resilience during Transplant (SMART) study (R01NR008583; U10CA098543; U10CA095861) is an ongoing multi-site Children's Oncology Group randomized clinical trial testing the efficacy of a therapeutic music video intervention for adolescents/young adults (11-24 years of age) with cancer undergoing stem cell transplant. Treatment fidelity strategies from our trial are consistent with the National Institutes of Health (NIH) Behavior Change Consortium Treatment Fidelity Workgroup (BCC) recommendations and provide a successful working model for treatment fidelity implementation in a large, multi-site behavioral intervention study. In this paper, we summarize 20 specific treatment fidelity strategies used in the SMART trial and how these strategies correspond with NIH BCC recommendations in five specific areas: (1) study design, (2) training providers, (3) delivery of treatment, (4) receipt of treatment, and (5) enactment of treatment skills. Increased use and reporting of treatment fidelity procedures is essential in advancing the reliability and validity of behavioral intervention research. The SMART trial provides a strong model for the application of fidelity strategies to improve scientific findings and addresses the absence of published literature, illustrating the application of BCC recommendations in behavioral intervention studies. Copyright © 2010 John Wiley & Sons, Ltd.

Spectroscopic data for thermal infrared remote sensing

NASA Technical Reports Server (NTRS)

Varanasi, P.; Nemtchinov, V.; Li, Z.

1995-01-01

There has been extensive world-wide use of chloro-fluoro-carbons (CFC's), especially CFC-11 (CFCl3) and CFC-12 (CF2Cl2), hydro-chloro-fluoro-carbons (HCFC's), HCFC-22 (CHFCl2) in particular, and sulphur hexaflouride (SF6) in numerous many industrial applications. These chemicals possess either a strong ozone-depletion potential or a global-warming potential, or both, and pose a threat to the inhabitability of our planet. Recognition of this fact has led to significant curtailment, if not total banishment, of their use globally. However, as recent satellite observations have shown, decline in their atmospheric concentrations may not be immediate. The marked depletion of ozone which has been observed in recent years at high latitudes has made infrared remote sensing of the atmosphere an activity of high priority. The success of any infrared remote sensing experiment conducted in the atmosphere depends upon the availability of accurate, high-resolution, spectroscopic data that are applicable to that experiment. This paper presents a preliminary phase of a multi-faceted work using a Fourier-transform spectrometer (FTS) which is in progress in our laboratory. The concept of how laboratory-borne measurements can be geared toward obtaining a database that is directly applicable to satellite-borne remote sensing missions is the main thrust of this paper which addresses itself to ongoing or planned international space missions. Spectroscopic data on the unresolvable bands of the above mentioned as well as several other man-made gases and on the individual spectral lines of such naturally present trace gases as CO2, N2O, NH3, and CH4 are presented. There is often significant overlap between the isolated lines of better known bands of the more abundant species and the weaker absorption features identifiable as bands of the currently less abundant CFC's, HCFC's, and SF6.

Spectroscopic wear detector

NASA Technical Reports Server (NTRS)

Madzsar, George C. (Inventor)

1993-01-01

The elemental composition of a material exposed to hot gases and subjected to wear is determined. Atoms of an elemental species not appearing in this material are implanted in a surface at a depth based on the maximum allowable wear. The exhaust gases are spectroscopically monitored to determine the exposure of these atoms when the maximum allowable wear is reached.

Childhood traumatic grief: a multi-site empirical examination of the construct and its correlates.

PubMed

Brown, Elissa J; Amaya-Jackson, Lisa; Cohen, Judith; Handel, Stephanie; Thiel De Bocanegra, Heike; Zatta, Eileen; Goodman, Robin F; Mannarino, Anthony

2008-01-01

This study evaluated the construct of childhood traumatic grief (CTG) and its correlates through a multi-site assessment of 132 bereaved children and adolescents. Youth completed a new measure of the characteristics, attributions, and reactions to exposure to death (CARED), as well as measures of CTG, posttraumatic stress disorder (PTSD), depression, and anger. CTG was distinct from but highly correlated with PTSD, depression, and, to a lesser degree, anger. In contrast to a recent study of complicated grief, CTG severity was significantly associated with the degree to which the death was viewed as traumatic. CTG was also associated with caregivers' emotional reaction at the time of the death and caregivers' current sadness. Clinical implications and recommendations for future research are discussed.

Breakup effects on alpha spectroscopic factors of 16O

NASA Astrophysics Data System (ADS)

Adhikari, S.; Basu, C.; Sugathan, P.; Jhinghan, A.; Behera, B. R.; Saneesh, N.; Kaur, G.; Thakur, M.; Mahajan, R.; Dubey, R.; Mitra, A. K.

2017-01-01

The triton angular distribution for the 12C(7Li,t)16O* reaction is measured at 20 MeV, populating discrete states of 16O. Continuum discretized coupled reaction channel calculations are used to to extract the alpha spectroscopic properties of 16O states instead of the distorted wave born approximation theory to include the effects of breakup on the transfer process. The alpha reduced width, spectroscopic factors and the asymptotic normalization constant (ANC) of 16O states are extracted. The error in the spectroscopic factor is about 35% and in that of the ANC about 27%.

A NEAR-INFRARED SPECTROSCOPIC SURVEY OF COOL WHITE DWARFS IN THE SLOAN DIGITAL SKY SURVEY

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kilic, Mukremin; Kowalski, Piotr M.; Von Hippel, Ted

2009-07-15

We present near-infrared photometric observations of 15 and spectroscopic observations of 38 cool white dwarfs (WDs). This is the largest near-infrared spectroscopic survey of cool WDs to date. Combining the Sloan Digital Sky Survey photometry and our near-infrared data, we perform a detailed model atmosphere analysis. The spectral energy distributions of our objects are explained fairly well by model atmospheres with temperatures ranging from 6300 K down to 4200 K. Two WDs show significant absorption in the infrared, and are best explained with mixed H/He atmosphere models. Based on the up-to-date model atmosphere calculations by Kowalski and Saumon, we findmore » that the majority of the stars in our sample have hydrogen-rich atmospheres. We do not find any pure helium atmosphere WDs below 5000 K, and we find a trend of increasing hydrogen to helium ratio with decreasing temperature. These findings present an important challenge to understanding the spectral evolution of WDs.« less

Review of spectroscopic parameters for upper atmospheric measurements

NASA Technical Reports Server (NTRS)

Smith, M. A. H. (Editor)

1985-01-01

The workshop included communication of spectroscopic data requirements for the planned upper atmosphere research satellite (UARS) mission, review of the status of currently available spectroscopic parameters, and recommendation of additional studies. The objectives were accomplished and resulted in a series of general and specific recommendations for laboratory spectroscopy research to meet the needs of UARS and other atmospheric remote sensing programs.

T.D.S. spectroscopic databank for spherical tops: DOS version

NASA Astrophysics Data System (ADS)

Tyuterev, V. G.; Babikov, Yu. L.; Tashkun, S. A.; Perevalov, V. I.; Nikitin, A.; Champion, J.-P.; Wenger, C.; Pierre, C.; Pierre, G.; Hilico, J.-C.; Loete, M.

1994-10-01

T.D.S. (Traitement de Donnees Spectroscopiques or Tomsk-Dijon-Spectroscopy project) is a computer package concerned with high resolution spectroscopy of spherical top molecules like CH4, CF4, SiH4, SiF4, SnH4, GeH4, SF6, etc. T.D.S. contains information, fundamental spectroscopic data (energies, transition moments, spectroscopic constants) recovered from comprehensive modeling and simultaneous fitting of experimental spectra, and associated software written in C. The T.D.S. goal is to provide an access to all available information on vibration-rotation molecular states and transitions including various spectroscopic processes (Stark, Raman, etc.) under extended conditions based on extrapolations of laboratory measurements using validated theoretical models. Applications for T.D.S. may include: education/training in molecular physics, quantum chemistry, laser physics; spectroscopic applications (analysis, laser spectroscopy, atmospheric optics, optical standards, spectroscopic atlases); applications to environment studies and atmospheric physics (remote sensing); data supply for specific databases; and to photochemistry (laser excitation, multiphoton processes). The reported DOS-version is designed for IBM and compatible personal computers.

In silico concurrent multisite pH titration in proteins.

PubMed

Hu, Hao; Shen, Lin

2014-07-30

The concurrent proton binding at multiple sites in macromolecules such as proteins and nucleic acids is an important yet challenging problem in biochemistry. We develop an efficient generalized Hamiltonian approach to attack this issue. Based on the previously developed generalized-ensemble methods, an effective potential energy is constructed which combines the contributions of all (relevant) protonation states of the molecule. The effective potential preserves important phase regions of all states and, thus, allows efficient sampling of these regions in one simulation. The need for intermediate states in alchemical free energy simulations is greatly reduced. Free energy differences between different protonation states can be determined accurately and enable one to construct the grand canonical partition function. Therefore, the complicated concurrent multisite proton titration process of protein molecules can be satisfactorily simulated. Application of this method to the simulation of the pKa of Glu49, Asp50, and C-terminus of bovine pancreatic trypsin inhibitor shows reasonably good agreement with published experimental work. This method provides an unprecedented vivid picture of how different protonation states change their relative population upon pH titration. We believe that the method will be very useful in deciphering the molecular mechanism of pH-dependent biomolecular processes in terms of a detailed atomistic description. Copyright © 2014 Wiley Periodicals, Inc.

Vegetation's red edge: a possible spectroscopic biosignature of extraterrestrial plants.

PubMed

Seager, S; Turner, E L; Schafer, J; Ford, E B

2005-06-01

Earth's deciduous plants have a sharp order-of-magnitude increase in leaf reflectance between approximately 700 and 750 nm wavelength. This strong reflectance of Earth's vegetation suggests that surface biosignatures with sharp spectral features might be detectable in the spectrum of scattered light from a spatially unresolved extrasolar terrestrial planet. We assess the potential of Earth's step-function-like spectroscopic feature, referred to as the "red edge," as a tool for astrobiology. We review the basic characteristics and physical origin of the red edge and summarize its use in astronomy: early spectroscopic efforts to search for vegetation on Mars and recent reports of detection of the red edge in the spectrum of Earthshine (i.e., the spatially integrated scattered light spectrum of Earth). We present Earthshine observations from Apache Point Observatory (New Mexico) to emphasize that time variability is key to detecting weak surface biosignatures such as the vegetation red edge. We briefly discuss the evolutionary advantages of vegetation's red edge reflectance, and speculate that while extraterrestrial "light-harvesting organisms" have no compelling reason to display the exact same red edge feature as terrestrial vegetation, they might have similar spectroscopic features at different wavelengths than terrestrial vegetation. This implies that future terrestrial-planet-characterizing space missions should obtain data that allow time-varying, sharp spectral features at unknown wavelengths to be identified. We caution that some mineral reflectance edges are similar in slope and strength to vegetation's red edge (albeit at different wavelengths); if an extrasolar planet reflectance edge is detected care must be taken with its interpretation.

Solar radio observations and radio interference monitoring in Roztoky

NASA Astrophysics Data System (ADS)

Monstein, C.; Baluďanský, D.

2013-10-01

This paper is part of a planned measurement campaign in which spectrum measurements were carried out at different locations worldwide within potential locations of the e-Callisto network. The results of measurements at the Callisto observing station in Roztoky, which took place at the beginning of May 2013, are presented. Measurements were made out with a special low cost broadband logarithmic periodic antenna connected to a Callisto spectrometer designed and built at ETH Zurich (Benz, 2004). This study provides the technical basis to decide whether it is possible to make solar spectroscopic measurements below 1 GHz (λ>30 cm) at the observing station. In terms of electromagnetic interference, Roztoky is not perfect for broadband spectroscopic solar radio astronomy observations due to non negligible radio interference level from the nearby FM-transmitters. Nevertheless, low frequency observations below 80 MHz, as well as observations in some small bands above 116 MHz can be done.

Spectroscopic observations of southern nearby galaxies. I. NGC 2442

NASA Astrophysics Data System (ADS)

Bajaja, E.; Agüero, E.; Paolantonio, S.

1999-04-01

The galaxy NGC 2442 was observed with a REOSC spectrograph, installed in the 2.15 m CASLEO telescope, in order to derive galactic parameters from the observed optical lines and to compare them with the results of radioastronomical observations made in the continuum, at 843 MHz, with the MOST and in the CO lines with the SEST telescope. Recent publications allowed us to extend the comparison to results from interferometric observations of Hα and H I 21 cm lines and of the continuum at 1415 MHz. The long slit observations were made placing the 5farcm 8 slit at six different positions on the optical image of the galaxy. The emission line intensity ratios at the nuclear region indicate that NGC 2442 is a LINER. The electron temperature and volume density are Te ~ 14 000 K and Ne ~ 530 cm(-3) , respectively. In contrast, a spectrum of a region 87arcsec to the NE shows the typical characteristics of a H Ii region. In this case Te ~ 6,500 K and Ne ~ 10 cm(-3) . Good correlations between the distributions of intensities, velocity fields and rotation curves have been found for the optical and radio lines. It is shown that the three intensity peaks along the line at PA = 40degr were not resolved by the observations at radio frequencies. The steep central rotation curve seen in CO has been confirmed and improved showing the existence of a disc or a ring, with a radius of 12.5 arcsec, rotating at 216/sin(i) km s(-1). Two velocity components in three optical spectra obtained in the nuclear region, have been related to two small Hα regions close to the nucleus and to the central ring. Asymmetries in the distributions of the emitting sources and irregularities in their velocity fields indicate the need of modelling the galaxy before any dynamical study is attempted. Based on observations made in the Complejo Astronomico El Leoncito, operated under agreement between the Consejo Nacional de Investigaciones Cientificas y Tecnicas de la Republica Argentina and the National

Spectroscopic detection

DOEpatents

Woskov, Paul P.; Hadidi, Kamal

2003-01-01

In embodiments, spectroscopic monitor monitors modulated light signals to detect low levels of contaminants and other compounds in the presence of background interference. The monitor uses a spectrometer that includes a transmissive modulator capable of causing different frequency ranges to move onto and off of the detector. The different ranges can include those with the desired signal and those selected to subtract background contributions from those with the desired signal. Embodiments of the system are particularly useful for monitoring metal concentrations in combustion effluent.

Applying probabilistic temporal and multisite data quality control methods to a public health mortality registry in Spain: a systematic approach to quality control of repositories.

PubMed

Sáez, Carlos; Zurriaga, Oscar; Pérez-Panadés, Jordi; Melchor, Inma; Robles, Montserrat; García-Gómez, Juan M

2016-11-01

To assess the variability in data distributions among data sources and over time through a case study of a large multisite repository as a systematic approach to data quality (DQ). Novel probabilistic DQ control methods based on information theory and geometry are applied to the Public Health Mortality Registry of the Region of Valencia, Spain, with 512 143 entries from 2000 to 2012, disaggregated into 24 health departments. The methods provide DQ metrics and exploratory visualizations for (1) assessing the variability among multiple sources and (2) monitoring and exploring changes with time. The methods are suited to big data and multitype, multivariate, and multimodal data. The repository was partitioned into 2 probabilistically separated temporal subgroups following a change in the Spanish National Death Certificate in 2009. Punctual temporal anomalies were noticed due to a punctual increment in the missing data, along with outlying and clustered health departments due to differences in populations or in practices. Changes in protocols, differences in populations, biased practices, or other systematic DQ problems affected data variability. Even if semantic and integration aspects are addressed in data sharing infrastructures, probabilistic variability may still be present. Solutions include fixing or excluding data and analyzing different sites or time periods separately. A systematic approach to assessing temporal and multisite variability is proposed. Multisite and temporal variability in data distributions affects DQ, hindering data reuse, and an assessment of such variability should be a part of systematic DQ procedures. © The Author 2016. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Spectroscopic ellipsometry study on E2 peak splitting of Si-Ge short period superlattices

NASA Astrophysics Data System (ADS)

Kim, Y. D.; Klein, M. V.; Baribeau, J.-M.; Hwang, S. H.; Whang, K. W.; Yoon, E.

1997-06-01

We report spectroscopic ellipsometry (SE) studies on (Si)2(Ge)12, (Si)6(Ge)2, and (Si)12(Ge)2 short period superlattices (SLs) whose optical response has not been reported yet. Multilayer calculations enabled us to determine the dielectric response of the superlattice layers. We report the clear observation of splitting of the E2 peak in (Si)m(Ge)n superlattices contrary to the previous SE report that the separation was observed only in larger period SLs.

Stochastic generators of multi-site daily temperature: comparison of performances in various applications

NASA Astrophysics Data System (ADS)

Evin, Guillaume; Favre, Anne-Catherine; Hingray, Benoit

2018-02-01

We present a multi-site stochastic model for the generation of average daily temperature, which includes a flexible parametric distribution and a multivariate autoregressive process. Different versions of this model are applied to a set of 26 stations located in Switzerland. The importance of specific statistical characteristics of the model (seasonality, marginal distributions of standardized temperature, spatial and temporal dependence) is discussed. In particular, the proposed marginal distribution is shown to improve the reproduction of extreme temperatures (minima and maxima). We also demonstrate that the frequency and duration of cold spells and heat waves are dramatically underestimated when the autocorrelation of temperature is not taken into account in the model. An adequate representation of these characteristics can be crucial depending on the field of application, and we discuss potential implications in different contexts (agriculture, forestry, hydrology, human health).

SDSS-IV MaNGA: the spectroscopic discovery of strongly lensed galaxies

NASA Astrophysics Data System (ADS)

Talbot, Michael S.; Brownstein, Joel R.; Bolton, Adam S.; Bundy, Kevin; Andrews, Brett H.; Cherinka, Brian; Collett, Thomas E.; More, Anupreeta; More, Surhud; Sonnenfeld, Alessandro; Vegetti, Simona; Wake, David A.; Weijmans, Anne-Marie; Westfall, Kyle B.

2018-06-01

We present a catalogue of 38 spectroscopically detected strong galaxy-galaxy gravitational lens candidates identified in the Sloan Digital Sky Survey IV (SDSS-IV). We were able to simulate narrow-band images for eight of them demonstrating evidence of multiple images. Two of our systems are compound lens candidates, each with two background source-planes. One of these compound systems shows clear lensing features in the narrow-band image. Our sample is based on 2812 galaxies observed by the Mapping Nearby Galaxies at APO (MaNGA) integral field unit (IFU). This Spectroscopic Identification of Lensing Objects (SILO) survey extends the methodology of the Sloan Lens ACS Survey (SLACS) and BOSS Emission-Line Survey (BELLS) to lower redshift and multiple IFU spectra. We searched ˜1.5 million spectra, of which 3065 contained multiple high signal-to-noise ratio background emission-lines or a resolved [O II] doublet, that are included in this catalogue. Upon manual inspection, we discovered regions with multiple spectra containing background emission-lines at the same redshift, providing evidence of a common source-plane geometry which was not possible in previous SLACS and BELLS discovery programs. We estimate more than half of our candidates have an Einstein radius ≳ 1.7 arcsec, which is significantly greater than seen in SLACS and BELLS. These larger Einstein radii produce more extended images of the background galaxy increasing the probability that a background emission-line will enter one of the IFU spectroscopic fibres, making detection more likely.

Vertical distribution of Martian aerosols from SPICAM/Mars-Express limb observations

NASA Astrophysics Data System (ADS)

Fedorova, A.; Korablev, O.; Bertaux, J.-L.; Rodin, A.; Perrier, S.; Moroz, V. I.

Limb spectroscopic observations provide invaluable information about vertical distribution of main atmospheric components in the Martian atmosphere, in particular vertical distribution and structure of aerosols, which play an important role in the heat balance of the planet. Only limited set of successful limb spectroscopic observations have been carried out on Mars so far, including those by MGS/TES spectrometer and Thermoscan and Auguste experiments of Phobos mission. Currently SPICAM instrument onboard Mars-Express spacecraft has accomplished several sequences of limb observations. First analysis of limb sounding data received by SPICAM IR and UV channels, which imply the presence of fine, deep, optically thin aerosol fraction extended over broad range of altitudes, is presented.

EIT Observations of Coronal Mass Ejections

NASA Technical Reports Server (NTRS)

Gurman, J. B.; Fisher, Richard B. (Technical Monitor)

2000-01-01

Before the Solar and Heliospheric Observatory (SOHO), we had only the sketchiest of clues as to the nature and topology of coronal mass ejections (CMEs) below 1.1 - 1.2 solar radii. Occasionally, dimmings (or 'transient coronal holes') were observed in time series of soft X-ray images, but they were far less frequent than CME's. Simply by imaging the Sun frequently and continually at temperatures of 0.9 - 2.5 MK we have stumbled upon a zoo of CME phenomena in this previously obscured volume of the corona: (1) waves, (2) dimmings, and (3) a great variety of ejecta. In the three and a half years since our first observations of coronal waves associated with CME's, combined Large Angle Spectroscopic Coronagraph (LASCO) and extreme ultra-violet imaging telescope (EIT) synoptic observations have become a standard prediction tool for space weather forecasters, but our progress in actually understanding the CME phenomenon in the low corona has been somewhat slower. I will summarize the observations of waves, hot (> 0.9 MK) and cool ejecta, and some of the interpretations advanced to date. I will try to identify those phenomena, analysis of which could most benefit from the spectroscopic information available from ultraviolet coronograph spectrometer (UVCS) observations.

The Study to Explore Early Development (SEED): A Multisite Epidemiologic Study of Autism by the Centers for Autism and Developmental Disabilities Research and Epidemiology (CADDRE) Network

ERIC Educational Resources Information Center

Schendel, Diana E.; DiGuiseppi, Carolyn; Croen, Lisa A.; Fallin, M. Daniele; Reed, Philip L.; Schieve, Laura A.; Wiggins, Lisa D.; Daniels, Julie; Grether, Judith; Levy, Susan E.; Miller, Lisa; Newschaffer, Craig; Pinto-Martin, Jennifer; Robinson, Cordelia; Windham, Gayle C.; Alexander, Aimee; Aylsworth, Arthur S.; Bernal, Pilar; Bonner, Joseph D.; Blaskey, Lisa; Bradley, Chyrise; Collins, Jack; Ferretti, Casara J.; Farzadegan, Homayoon; Giarelli, Ellen; Harvey, Marques; Hepburn, Susan; Herr, Matthew; Kaparich, Kristina; Landa, Rebecca; Lee, Li-Ching; Levenseller, Brooke; Meyerer, Stacey; Rahbar, Mohammad H.; Ratchford, Andria; Reynolds, Ann; Rosenberg, Steven; Rusyniak, Julie; Shapira, Stuart K.; Smith, Karen; Souders, Margaret; Thompson, Patrick Aaron; Young, Lisa; Yeargin-Allsopp, Marshalyn

2012-01-01

The Study to Explore Early Development (SEED), a multisite investigation addressing knowledge gaps in autism phenotype and etiology, aims to: (1) characterize the autism behavioral phenotype and associated developmental, medical, and behavioral conditions and (2) investigate genetic and environmental risks with emphasis on immunologic, hormonal,…

Spectroscopic classification of AT 2017cfd as a young Type Ia supernova

NASA Astrophysics Data System (ADS)

Vinko, J.; Wheeler, J. C.

2017-03-01

We report the spectroscopic observation of AT 2017cfd, a transient discovered by the Lick Observatory Supernova Search (LOSS) on 2017-03-16. A spectrum (range 3700-9300 Angstroms), taken with the new "Low Resolution Spectrograph-2" (LRS2) on the 10m Hobby-Eberly Telescope at McDonald Observatory by Steve Odewahn on 2017-03-18.16 UT, is similar to that of a Type Ia supernova before maximum light.

Process evaluation in a multisite, primary obesity-prevention trial in American Indian schoolchildren.

PubMed

Helitzer, D L; Davis, S M; Gittelsohn, J; Going, S B; Murray, D M; Snyder, P; Steckler, A B

1999-04-01

We describe the development, implementation, and use of the process evaluation component of a multisite, primary obesity prevention trial for American Indian schoolchildren. We describe the development and pilot testing of the instruments, provide some examples of the criteria for instrument selection, and provide examples of how process evaluation results were used to document and refine intervention components. The theoretical and applied framework of the process evaluation was based on diffusion theory, social learning theory, and the desire for triangulation of multiple modes of data collection. The primary objectives of the process evaluation were to systematically document the training process, content, and implementation of 4 components of the intervention. The process evaluation was developed and implemented collaboratively so that it met the needs of both the evaluators and those who would be implementing the intervention components. Process evaluation results revealed that observation and structured interviews provided the most informative data; however, these methods were the most expensive and time consuming and required the highest level of skill to undertake. Although the literature is full of idealism regarding the uses of process evaluation for formative and summative purposes, in reality, many persons are sensitive to having their work evaluated in such an in-depth, context-based manner as is described. For this reason, use of structured, quantitative, highly objective tools may be more effective than qualitative methods, which appear to be more dependent on the skills and biases of the researcher and the context in which they are used.

Determination of emamectin benzoate in medicated fish feed: a multisite study.

PubMed

Farer, Leslie J

2005-01-01

A new method was developed for the quantitation of emamectin benzoate in medicated fish feed at levels between 1 and 30 ppm. The new procedure, based on a previously reported assay, consists of a wet methanolic extraction of ground feed, followed by solid-phase extraction and injection onto a gradient liquid chromatographic system. A multisite study involving 3 laboratories (the developing laboratory and 2 independent laboratories) was performed to evaluate precision, recovery, linearity, and sensitivity. Mean recove;ries for triplicate analyses at 3 levels, performed by 2 analysts per laboratory, were between 89 and 97%, with coefficients of variation ranging from 1.6 to 8.6%. Coefficients of determination (r2) obtained from the plotted data were > or =0.993. The precision of the method, determined from 6 replicate preparations from the same batch of medicated feed assayed in 3 separate trials per laboratory, was between 0.6 and 5.8%. The quantitation limit was established at 0.5 ppm. Specificity and robustness studies were performed by the developing laboratory.

Videoteleconferencing for administration of a multisite obstetrics and gynecology core clerkship.

PubMed

Browne, M W; Hines, J F; Satin, A J; Haffner, W H

2000-03-01

Recent changes and trends in health care delivery have required medical schools to use multiple sites to obtain adequate patient exposure for their students. Decentralization of clinical undergraduate medical education may lead to a lack of continuity in curricula, evaluation, and feedback. We describe the use of interactive videoteleconferencing as a tool to link and improve a multi-site undergraduate core clerkship in obstetrics and gynecology. The Uniformed Services University of the Health Sciences, Bethesda, Maryland, currently utilizes five geographically separate sites for its 6-week core clerkship in obstetrics and gynecology. The site coordinators, clerkship director, and administrative personnel from the parent institution meet approximately 3 weeks after the completion of each core clerkship for live, real-time, and interactive broadcast to complete student evaluations, review curricula, and discuss problems with current students and other pertinent educational issues. Videoteleconferencing provides a mechanism to ensure consistency in curriculum and student evaluations and provides administrative support to distant sites. Furthermore, it enables site coordinators to keep the clerkship director abreast of students and clerkship issues.

Quality assurance of data collection in the multi-site community randomized trial and prevalence survey of the children's healthy living program.

PubMed

Yamanaka, Ashley; Fialkowski, Marie Kainoa; Wilkens, Lynne; Li, Fenfang; Ettienne, Reynolette; Fleming, Travis; Power, Julianne; Deenik, Jonathan; Coleman, Patricia; Leon Guerrero, Rachael; Novotny, Rachel

2016-09-02

Quality assurance plays an important role in research by assuring data integrity, and thus, valid study results. We aim to describe and share the results of the quality assurance process used to guide the data collection process in a multi-site childhood obesity prevalence study and intervention trial across the US Affiliated Pacific Region. Quality assurance assessments following a standardized protocol were conducted by one assessor in every participating site. Results were summarized to examine and align the implementation of protocol procedures across diverse settings. Data collection protocols focused on food and physical activity were adhered to closely; however, protocols for handling completed forms and ensuring data security showed more variability. Quality assurance protocols are common in the clinical literature but are limited in multi-site community-based studies, especially in underserved populations. The reduction in the number of QA problems found in the second as compared to the first data collection periods for the intervention study attest to the value of this assessment. This paper can serve as a reference for similar studies wishing to implement quality assurance protocols of the data collection process to preserve data integrity and enhance the validity of study findings. NIH clinical trial #NCT01881373.

Photometric and Spectroscopic Analysis of CP Stars Under Indo-Russian Collaboration

NASA Astrophysics Data System (ADS)

Joshi, S.; Semenko, E.; Moiseeva, A.; Joshi, G. C.; Joshi, Y. C.; Sachkov, M.

2015-04-01

The Indo-Russian collaboration is a joint venture between the astronomers of India (ARIES) and Russia (SAO and INASAN) to develop scientific and technical interactions by making use of observational facilities. Here we present the results obtained after the “Magnetic Conference” that was held in the Special Astrophysical Observatory, Russia in 2010. The analysis of time-series photometric CCD observations of HD 98851 shows a pulsation period of 1fh55, which is consistent with the period reported previously. We have also found a signature of short-term periodic variability in HD 207561. The analysis of high-resolution spectroscopic and spectropolarimetric observations of the sample stars revealed characteristics similar to Am stars, hence the excitation of the low-overtone pulsations are expected in these stars.

First Spectroscopic Confirmations of z ∼ 7.0 Ly α Emitting Galaxies in the LAGER Survey

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hu, Weida; Wang, Junxian; Kang, Wenyong

Narrowband imaging is a highly successful approach for finding large numbers of high-redshift Ly α emitting galaxies (LAEs) up to z ∼ 6.6. However, at z ≳ 7 there are as of yet only three narrowband selected LAEs with spectroscopic confirmations (two at z ∼ 6.9–7.0, one at z ∼ 7.3), which hinders extensive studies on cosmic reionization and galaxy evolution at this key epoch. We have selected 23 candidate z ∼ 6.9 LAEs in COSMOS field with the large area narrowband survey Lyman-Alpha Galaxies at the End of Reionization (LAGER). In this work, we present spectroscopic follow-up observations ofmore » 12 candidates using the Inamori Magellan Areal Camera and Spectrograph on Magellan. For nine of these, the observations are sufficiently deep to detect the expected lines. Ly α emission lines are identified in six sources (yielding a success rate of 2/3), including three luminous LAEs with Ly α luminosities of L {sub Lyα} ∼ 10{sup 43.5} erg s{sup −1}, the highest among known spectroscopically confirmed galaxies at ≳7.0. This triples the sample size of spectroscopically confirmed narrowband selected LAEs at z ≳ 7, and confirms the bright-end bump in the Ly α luminosity function we previously derived based on the photometric sample, supporting a patchy reionization scenario. Two luminous LAEs appear physically linked with a projected distance of 1.1 pMpc and velocity difference of ∼170 km s{sup −1}. They likely sit in a common ionized bubble produced by themselves or with close neighbors, which reduces the intergalactic medium attenuation of Ly α . A tentative narrow N v λ 1240 line is seen in one source, hinting at activity of a central massive black hole with metal-rich line-emitting gas.« less

Photometric and Spectroscopic Analysis for the Determination of Physical Parameters of an Eclipsing Binary Star System

NASA Astrophysics Data System (ADS)

Reid, Piper

2013-01-01

A binary star system is a pair of stars that are bound together by gravity. Most of the stars that we see in the night sky are members of multiple star systems. A system of stars where one star passes in front of the other (as observed from Earth) on a periodic basis is called an eclipsing binary. Eclipsing binaries can have very short rotational periods and in all cases these pairs of stars are so far away that they can only be resolved from Earth as a single point of light. The interaction of the two stars serves to produce physical phenomena that can be observed and used to study stellar properties. By careful data collection and analysis is it possible for an amateur astronomer using commercial, low cost equipment (including a home built spectroscope) to gather photometric (brightness versus time) and spectroscopic (brightness versus wavelength) data, analyze the data, and calculate the physical properties of a binary star system? Using a CCD camera, tracking mount and telescope photometric data of BB Pegasi was collected and a light curve produced. 57 Cygni was also studied using a spectroscope, tracking mount and telescope to prove that Doppler shift of Hydrogen Balmer absorption lines can be used to determine radial velocity. The orbital period, orbital velocity, radius of each star, separation of the two stars and mass of each star was calculated for the eclipsing binary BB Pegasi using photometric and spectroscopic data and Kepler’s 3rd Law. These data were then compared to published data. By careful use of consumer grade astronomical equipment it is possible for an amateur astronomer to determine an array of physical parameters of a distant binary star system from a suburban setting.

In Situ Raman Spectroscopic Observations of Gas-Saturated Rising Oil droplets: Simulation with Decane as an Oil-Equivalent Substitute

NASA Astrophysics Data System (ADS)

Peltzer, E. T.; Walz, P. M.; Brewer, P. G.

2016-02-01

Oil droplets rising from the sea floor, whether from seeps or well leakage, contain very large quantities of dissolved gas that profoundly affects their density and critical oil-water interfacial characteristics. The primary dissolved gas is methane which may be up to 30% of the molar volume. This can create a hydrate skin as the methane gas is shed from the oil as it rises through the water column, thus decreasing in pressure and increasing in temperature, and steadily changing the rising droplet buoyancy. We have explored this phenomenon by executing controlled ROV based experiments with a "bubble cup" technique in which a small volume of gas saturated decane (saturated with pure methane, a mix of methane and nitrogen , or a mix of methane and CO2) is interrogated by laser Raman spectroscopy. The use of decane as an oil "substitute" is required since natural oil samples are highly fluorescent due to the presence of polycyclic aromatic hydrocarbons. We have devised Matlab techniques for extracting the spectroscopic dissolved methane signal from the thicket of decane peaks that surround it. We have directly observed the rate at which gases are lost from the "oil" per unit area at depths in the water column that are both within and outside the hydrate forming phase boundary. We have compared the behavior of both a non-hydrate forming dissolved gas (nitrogen) with CO2 where the hydrate phase boundary is at significantly shallower depth. The results indicate complex interfacial behavior and physical chemistry. We did not observe direct gas bubble formation on the decane outer surface but did observe gas bubble formation within the oil droplets as they rose through the water column. Because there are significant energy barriers for homogeneous bubble formation within the decane phase, we took this as evidence of significant gas super-saturation within the oil droplet. The gas loss rates increased significantly in all cases when the hydrate phase boundary was crossed.

Obtaining the Electron Angular Momentum Coupling Spectroscopic Terms, jj

ERIC Educational Resources Information Center

Orofino, Hugo; Faria, Roberto B.

2010-01-01

A systematic procedure is developed to obtain the electron angular momentum coupling (jj) spectroscopic terms, which is based on building microstates in which each individual electron is placed in a different m[subscript j] "orbital". This approach is similar to that used to obtain the spectroscopic terms under the Russell-Saunders (LS) coupling…

Multisite silicon neural probes with integrated silicon nitride waveguides and gratings for optogenetic applications.

PubMed

Shim, Euijae; Chen, Yu; Masmanidis, Sotiris; Li, Mo

2016-03-04

Optimal optogenetic perturbation of brain circuit activity often requires light delivery in a precise spatial pattern that cannot be achieved with conventional optical fibers. We demonstrate an implantable silicon-based probe with a compact light delivery system, consisting of silicon nitride waveguides and grating couplers for out-of-plane light emission with high spatial resolution. 473 nm light is coupled into and guided in cm-long waveguide and emitted at the output grating coupler. Using the direct cut-back and out-scattering measurement techniques, the propagation optical loss of the waveguide is measured to be below 3 dB/cm. The grating couplers provide collimated light emission with sufficient irradiance for neural stimulation. Finally, a probe with multisite light delivery with three output grating emitters from a single laser input is demonstrated.

Hybrid Biodegradable Hydrogels Obtained from Nanoclay and Carboxymethylcellulose Polysaccharide: Hydrophilic, Kinetic, Spectroscopic and Morphological Properties.

PubMed

Nascimento, Denis W S; de Moura, Márcia R; Mattoso, Luiz H C; Aouada, Fauze A

2017-01-01

In this paper, series of novel nanocomposite hydrogels based on polyacrylamide (PAAm), carboxymethylcellulose (CMC) and nanoclay were synthesized. Hydrophilic, kinetic, spectroscopic and morphological properties were investigated as function of their constituents. Spectroscopic properties confirmed the obtaining of the nanocomposites. It was also observed that the nanocomposites have walls of pores with a more rugged morphology compared with the morphology of the hydrogel without clay, contributing to repel the water molecules. Besides, the results showed that the velocity and quantity of water uptake may be controlled by adjusting of matrix rigidity, i.e., nanoclay content into polymeric matrix. This behavior is required to future application in agriculture fields, specifically as carrier vehicle in controlled release of agrochemicals. Thus, these nanocomposites have technological application.

How Many Interviews Are Enough to Identify Metathemes in Multisited and Cross-Cultural Research? Another Perspective on Guest, Bunce, and Johnson's (2006) Landmark Study

ERIC Educational Resources Information Center

Hagaman, Ashley K.; Wutich, Amber

2017-01-01

There is much debate over the number of interviews needed to reach data saturation for themes and metathemes in qualitative research. The primary purpose of this study is to determine the number of interviews needed to reach data saturation for metathemes in multisited and cross-cultural research. The analysis is based on a cross-cultural study on…

Accurate potential energy curves, spectroscopic parameters, transition dipole moments, and transition probabilities of 21 low-lying states of the CO+ cation

NASA Astrophysics Data System (ADS)

Xing, Wei; Shi, Deheng; Zhang, Jicai; Sun, Jinfeng; Zhu, Zunlue

2018-05-01

This paper calculates the potential energy curves of 21 Λ-S and 42 Ω states, which arise from the first two dissociation asymptotes of the CO+ cation. The calculations are conducted using the complete active space self-consistent field method, which is followed by the valence internally contracted multireference configuration interaction approach with the Davidson correction. To improve the reliability and accuracy of the potential energy curves, core-valence correlation and scalar relativistic corrections, as well as the extrapolation of potential energies to the complete basis set limit are taken into account. The spectroscopic parameters and vibrational levels are determined. The spin-orbit coupling effect on the spectroscopic parameters and vibrational levels is evaluated. To better study the transition probabilities, the transition dipole moments are computed. The Franck-Condon factors and Einstein coefficients of some emissions are calculated. The radiative lifetimes are determined for a number of vibrational levels of several states. The transitions between different Λ-S states are evaluated. Spectroscopic routines for observing these states are proposed. The spectroscopic parameters, vibrational levels, transition dipole moments, and transition probabilities reported in this paper can be considered to be very reliable and can be used as guidelines for detecting these states in an appropriate spectroscopy experiment, especially for the states that were very difficult to observe or were not detected in previous experiments.

The Magellanic Inter-Cloud Project (MAGIC) III: first spectroscopic evidence of a dwarf stripping a dwarf

NASA Astrophysics Data System (ADS)

Carrera, Ricardo; Conn, Blair C.; Noël, Noelia E. D.; Read, Justin I.; López Sánchez, Ángel R.

2017-11-01

The Magellanic Bridge (MB) is a gaseous stream that links the Large (LMC) and Small (SMC) Magellanic Clouds. Current simulations suggest that the MB forms from a recent interaction between the Clouds. In this scenario, the MB should also have an associated stellar bridge formed by stars tidally stripped from the SMC by the LMC. There are several observational evidences for these stripped stars, from the presence of intermediate age populations in the MB and carbon stars, to the recent observation of an over-density of RR Lyrae stars offset from the MB. However, spectroscopic confirmation of stripped stars in the MB remains lacking. In this paper, we use medium resolution spectra to derive the radial velocities and metallicities of stars in two fields along the MB. We show from both their chemistry and kinematics that the bulk of these stars must have been tidally stripped from the SMC. This is the first spectroscopic evidence for a dwarf galaxy being tidally stripped by a larger dwarf.

Derivation of Mars Surface Scattering Properties from OMEGA Spot Pointing Observations

NASA Astrophysics Data System (ADS)

Pinet, P. C.; Daydou, Y.; Cord, A.; Chevrel, S. C.; Poulet, F.; Erard, S.; Bibring, J.-P.; Langevin, Y.; Melchiorri, R.; Bellucci, G.; Altieri, F.; Arvidson, R. E.; OMEGA Co-Investigator Team

2005-03-01

OMEGA emission phase function (EPF) observation shows that one may access from orbit to geology-driven surface scattering properties such as surface roughness. It has implications for spectroscopic interpretation and for CRISM observations to come.

Repeated assessment of orthotopic glioma pO2 by multi-site EPR oximetry: A technique with the potential to guide therapeutic optimization by repeated measurements of oxygen

PubMed Central

Khan, Nadeem; Mupparaju, Sriram; Hou, Huagang; Williams, Benjamin B.; Swartz, Harold

2011-01-01

Tumor hypoxia plays a vital role in therapeutic resistance. Consequently, measurements of tumor pO2 could be used to optimize the outcome of oxygen-dependent therapies, such as, chemoradiation. However, the potential optimizations are restricted by the lack of methods to repeatedly and quantitatively assess tumor pO2 during therapies, particularly in gliomas. We describe the procedures for repeated measurements of orthotopic glioma pO2 by multi-site electron paramagnetic resonance (EPR) oximetry. This oximetry approach provides simultaneous measurements of pO2 at more than one site in the glioma and contralateral cerebral tissue. The pO2 of intracerebral 9L, C6, F98 and U251 tumors, as well as contralateral brain, were measured repeatedly for five consecutive days. The 9L glioma was well oxygenated with pO2 of 27 - 36 mm Hg, while C6, F98 and U251 glioma were hypoxic with pO2 of 7 - 12 mm Hg. The potential of multi-site EPR oximetry to assess temporal changes in tissue pO2 was investigated in rats breathing 100% O2. A significant increase in F98 tumor and contralateral brain pO2 was observed on day 1 and day 2, however, glioma oxygenation declined on subsequent days. In conclusion, EPR oximetry provides the capability to repeatedly assess temporal changes in orthotopic glioma pO2. This information could be used to test and optimize the methods being developed to modulate tumor hypoxia. Furthermore, EPR oximetry could be potentially used to enhance the outcome of chemoradiation by scheduling treatments at times of increase in glioma pO2. PMID:22079559

A model for the spectroscopic variations of the peculiar symbiotic star MWC 560

NASA Technical Reports Server (NTRS)

Shore, Steven N.; Aufdenberg, Jason P.; Michalitsianos, A. G.

1994-01-01

In this note, we show that the ultraviolet and optical spectroscopic variability of this unique symbiotic star can be understood in terms of a time variable collimated stellar wind with a rapid acceleration near the source. Using the radial velocities observed during the ultraviolet bright phase, we find that a variation in the mass loss rate of a factor of ten can explain the ultraviolet spectral changes. The acceleration is far faster than normally observed in radiatively driven stellar winds and may be due to mechanical driving of the outflow from the disk.

Spectroscopic observations of ATLAS17lcs (SN 2017guv) and ASASSN-17mq (AT 2017gvo) by NUTS (NOT Un-biased Transient Survey)

NASA Astrophysics Data System (ADS)

Dong, Subo; Bose, Subhash; Stritzinger, M.; Holmbo, S.; Fraser, M.; Fedorets, G.

2017-10-01

The Nordic Optical Telescope (NOT) Unbiased Transient Survey (NUTS; ATel #8992) reports the spectroscopic classification of ATLAS17lcs (SN 2017guv) and ASASSN-17mq (AT 2017gvo) in host galaxies 2MASX J19132225-1648031 and CGCG 225-050, respectively.

Implementation of nursing conceptual models: observations of a multi-site research team.

PubMed

Shea, H; Rogers, M; Ross, E; Tucker, D; Fitch, M; Smith, I

1989-01-01

The general acceptance by nursing of the nursing process as the methodology of practice enabled nurses to have a common grounding for practice, research and theory development in the 1970s. It has become clear, however, that the nursing process is just that--a process. What is sorely needed is the nursing content for that process and consequently in the past 10 years nursing theorists have further developed their particular conceptual models (CM). Three major teaching hospitals in Toronto have instituted a conceptual model (CM) of nursing as a basis of nursing practice. Mount Sinai Hospital has adopted Roy's adaptation model; Sunnybrook Medical Centre, Kings's goal attainment model; and Toronto General Hospital, Orem's self-care deficit theory model. All of these hospitals are affiliated through a series of cross appointments with the Faculty of Nursing at the University of Toronto. Two community hospitals, Mississauga and Scarborough General, have also adopted Orem's model and are related to the University through educational, community and interest groups. A group of researchers from these hospitals and the University of Toronto have proposed a collaborative project to determine what impact using a conceptual model will make on nursing practice. Discussions among the participants of this research group indicate that there are observations associated with instituting conceptual models that can be identified early in the process of implementation. These observations may be of assistance to others contemplating the implementation of conceptually based practice in their institution.

PS1-29: Resources to Facilitate Multi-site Collaboration: the PRIMER Research Toolkit

PubMed Central

Greene, Sarah; Thompson, Ella; Baldwin, Laura-Mae; Neale, Anne Victoria; Dolor, Rowena

2010-01-01

Background and Aims: The national research enterprise has typically functioned in a decentralized fashion, resulting in duplicative or undocumented processes, impeding not only the pace of research, but diffusion of established best practices. To remedy this, many long-standing networks have begun capturing and documenting proven strategies to streamline and standardize various aspects of the research process. The project, “Partnership-driven Resources to IMprove and Enhance Research” (PRIMER), was funded through the Clinical and Translational Science Awards (CTSA) initiative to leverage the collective expertise from two networks: the HMO Research Network and Practice Based Research Networks (PBRNs). Each network has a shared goal of propagating research resources and best practices. Methods: We created and distributed an online survey to 92 CTSA and PBRN representatives in March, 2009 to define critical needs and existing resources that could inform a resource repository. The survey identified barriers and benefits to forming research partnerships, and assessed the perceived utility of various tools that could accelerate the research process. The study team identified, reviewed and organized tools based on the typical research trajectory from design to dissemination. Results: Fifty-five of 92 invitees (59%) completed the survey. Respondents rated the ability to conduct community-relevant research through true academic-community partnerships as the top-rated benefit of multi-site research, followed by the opportunity to accelerate translation of research into practice. The top two perceived barriers to multi-site research were ‘funding opportunities are not adequate (e.g., too few, not enough to support true collaborations), and ‘lack of research infrastructure to support [all] partners (e.g., no IT support, IRB, dedicated research staff). Respondents’ ratings of the utility of various tools and templates was used to guide development of an online

Raman spectroscopic monitoring of the bioeffects of nitroglycerin on Hb-O II in single red blood cell

NASA Astrophysics Data System (ADS)

Chiang, Huihua Kenny; Ruan, Hung-Shiang; Cheng, Hung-You; Fang, Tung-Ting

2007-02-01

Raman spectroscopy has been shown to have the potential for providing oxygenated ability of erythrocytes. Raman line at 1638 cm-1 has also been reported as one significant oxygenic indicator for erythrocytes. In this research, we develop the Raman spectroscopic monitoring of the bioeffects of Nitroglycerin on hemoglobin oxygen saturation in a single red blood cell (RBC). Nitroglycerin has been frequently used in the management of angina pectoris. Nitroglycerin liberates nitric oxide (NO) to blood vessels. NO is an oxidizer that easily converts hemoglobin to methemoglobin. The conversion may cause the decrease of oxygenated ability of erythrocytes. In this study, we observed the oxidize state of erythrocytes caused by the over dosage of Nitroglycerin. When the dose of Nitroglycerin exceeds 2x10 -4 M, the oxygenic state of erythrocytes decreases significantly. The Raman spectroscopic results demonstrate the observation of the bioeffects of Nitroglycerin on hemoglobin.

Whispering Gallery Optical Resonator Spectroscopic Probe and Method

NASA Technical Reports Server (NTRS)

Anderson, Mark S. (Inventor)

2014-01-01

Disclosed herein is a spectroscopic probe comprising at least one whispering gallery mode optical resonator disposed on a support, the whispering gallery mode optical resonator comprising a continuous outer surface having a cross section comprising a first diameter and a second diameter, wherein the first diameter is greater than the second diameter. A method of measuring a Raman spectrum and an Infra-red spectrum of an analyte using the spectroscopic probe is also disclosed.

Caring letters for suicide prevention: implementation of a multi-site randomized clinical trial in the U.S. military and Veteran Affairs healthcare systems.

PubMed

Luxton, David D; Thomas, Elissa K; Chipps, Joan; Relova, Rona M; Brown, Daphne; McLay, Robert; Lee, Tina T; Nakama, Helenna; Smolenski, Derek J

2014-03-01

Caring letters is a suicide prevention intervention that entails the sending of brief messages that espouse caring concern to patients following discharge from treatment. First tested more than four decades ago, this intervention is one of the only interventions shown in a randomized controlled trial to reduce suicide mortality rates. Due to elevated suicide risk among patients following psychiatric hospitalization and the steady increase in suicide rates among the U.S. military personnel, it is imperative to test interventions that may help prevent suicide among high-risk military personnel and veterans. This paper describes the design, methods, study protocol, and regulatory implementation processes for a multi-site randomized controlled trial that aims to evaluate the effectiveness of a caring emails intervention for suicide prevention in the military and VA healthcare systems. The primary outcome is suicide mortality rates to be determined 24 months post-discharge from index hospital stay. Healthcare re-utilization rates will also be evaluated and comprehensive data will be collected regarding suicide risk factors. Recommendations for navigating the military and VA research regulatory processes and implementing a multi-site clinical trial at military and VA hospitals are discussed. Published by Elsevier Inc.

The GEISA Spectroscopic Database as a Tool for Hyperspectral Earth' Tropospheric Remote Sensing Applications

NASA Astrophysics Data System (ADS)

Jacquinet-Husson, Nicole; Crépeau, Laurent; Capelle, Virginie; Scott, Noëlle; Armante, Raymond; Chédin, Alain

2010-05-01

Remote sensing of the terrestrial atmosphere has advanced significantly in recent years, and this has placed greater demands on the compilations in terms of accuracy, additional species, and spectral coverage. The successful performances of the new generation of hyperspectral Earth' atmospheric sounders like AIRS (Atmospheric Infrared Sounder -http://www-airs.jpl.nasa.gov/), in the USA, and IASI (Infrared Atmospheric Sounding Interferometer -http://earth-sciences.cnes.fr/IASI/) in Europe, which have a better vertical resolution and accuracy, compared to the previous satellite infrared vertical sounders, depend ultimately on the accuracy to which the spectroscopic parameters of the optically active gases are known, since they constitute an essential input to the forward radiative transfer models that are used to interpret their observations. In this context, the GEISA (1) (Gestion et Etude des Informations Spectroscopiques Atmosphériques: Management and Study of Atmospheric Spectroscopic Information) computer-accessible database, initiated in 1976, is continuously developed and maintained at LMD (Laboratoire de Météorologie Dynamique, France). The updated 2009 edition of GEISA (GEISA-09)is a system comprising three independent sub-databases devoted respectively to: line transition parameters, infrared and ultraviolet/visible absorption cross-sections, microphysical and optical properties of atmospheric aerosols. In this edition, the contents of which will be summarized, 50 molecules are involved in the line transition parameters sub-database, including 111 isotopes, for a total of 3,807,997 entries, in the spectral range from 10-6 to 35,877.031 cm-1. Currently, GEISA is involved in activities related to the assessment of the capabilities of IASI through the GEISA/IASI database derived from GEISA (2). Since the Metop (http://www.eumetsat.int) launch (October 19th 2006), GEISA/IASI is the reference spectroscopic database for the validation of the level-1 IASI data

A COMPARISON OF GALAXY COUNTING TECHNIQUES IN SPECTROSCOPICALLY UNDERSAMPLED REGIONS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Specian, Mike A.; Szalay, Alex S., E-mail: mspecia1@jhu.edu, E-mail: szalay@jhu.edu

2016-11-01

Accurate measures of galactic overdensities are invaluable for precision cosmology. Obtaining these measurements is complicated when members of one’s galaxy sample lack radial depths, most commonly derived via spectroscopic redshifts. In this paper, we utilize the Sloan Digital Sky Survey’s Main Galaxy Sample to compare seven methods of counting galaxies in cells when many of those galaxies lack redshifts. These methods fall into three categories: assigning galaxies discrete redshifts, scaling the numbers counted using regions’ spectroscopic completeness properties, and employing probabilistic techniques. We split spectroscopically undersampled regions into three types—those inside the spectroscopic footprint, those outside but adjacent to it,more » and those distant from it. Through Monte Carlo simulations, we demonstrate that the preferred counting techniques are a function of region type, cell size, and redshift. We conclude by reporting optimal counting strategies under a variety of conditions.« less

Are your spectroscopic data being used?

NASA Astrophysics Data System (ADS)

Gordon, Iouli E.; Potterbusch, Megan R.; Bouquin, Daina; Erdmann, Christopher C.; Wilzewski, Jonas S.; Rothman, Laurence S.

2016-09-01

The issue of availability of data and their presentation in spectroscopic publications is discussed. Different current practices are critically reviewed from the point of view of potential users, government policies, and merit of success of the authors. Indeed, properly providing the data benefits not only users but also the authors of the spectroscopic research. We will show that this increases citations to the spectroscopy papers and visibility of the research groups. Examples based on the statistical analyses of the articles published in the Journal of Molecular Spectroscopy will be shown. We will discuss different methods including supplementary materials to the Journals, public-curated databases and also new tools that can be utilized by spectroscopists.

The LAMOST spectroscopic survey of stars in the Kepler field of view: Activity indicators and stellar parameters

NASA Astrophysics Data System (ADS)

Molenda-Żakowicz, Joanna; Frasca, Antonio; De Cat, Peter; Catanzaro, Giovanni

2017-09-01

We summarize the results of the completed first round of the LAMOST-Kepler project, and describe the status of its on-going second round. As a result of the first round of this project, the atmospheric parameters (Teff, log g, and [Fe/H]), the spectral classification (spectral type and luminosity class), and the radial velocities (RV) have been measured for 51,385 stars. For 4031 stars, we were able to measure the projected rotational velocity, while the minimum detectable v sin i was 120 km s-1. For 8821 stars with more than one observation, we computed the χ-square probability that the detected RV variations have a random occurrence. Finally, we classified 442 stars as chromospherically active on the basis of the analysis of their Hα and Ca II-IRT fluxes. All our results have been obtained from the low-resolution (R ˜ 1800) spectroscopic observations acquired with the LAMOST instrument. Based on observations collected with the Large Sky Area Multi-Object Fiber Spectroscopic Telescope (LAMOST) located at the Xinglong Observatory, China.

DFT calculations on spectroscopic and structural properties of a NLO chromophore

NASA Astrophysics Data System (ADS)

Altürk, Sümeyye; Avci, Davut; Tamer, Ömer; Atalay, Yusuf

2016-03-01

The molecular geometry optimization, vibrational frequencies and gauge including atomic orbital (GIAO) 1H and 13C NMR chemical shift values of 2-(1'-(4'''-Methoxyphenyl)-5'-(thien-2″-yl)pyrrol-2'-yl)-1,3-benzothiazole as potential nonlinear optical (NLO) material were calculated using density functional theory (DFT) HSEh1PBE method with 6-311G(d,p) basis set. The best of our knowledge, this study have not been reported to date. Additionally, a detailed vibrational study was performed on the basis of potential energy distribution (PED) using VEDA program. It is noteworthy that NMR chemical shifts are quite useful for understanding the relationship between the molecular structure and electronic properties of molecules. The computed IR and NMR spectra were used to determine the types of the experimental bands observed. Predicted values of structural and spectroscopic parameters of the chromophore were compared with each other so as to display the effects of the different substituents on the spectroscopic and structural properties. Obtained data showed that there is an agreement between the predicted and experimental data.

Intrinsic folding of small peptide chains: spectroscopic evidence for the formation of beta-turns in the gas phase.

PubMed

Chin, Wutharath; Dognon, Jean-Pierre; Piuzzi, François; Tardivel, Benjamin; Dimicoli, Iliana; Mons, Michel

2005-01-19

Laser desorption of model peptides coupled to laser spectroscopic techniques enables the gas-phase observation of genuine secondary structures of biology. Spectroscopic evidence for the formation of beta-turns in gas-phase peptide chains containing glycine and phenylalanine residues establishes the intrinsic stability of these forms and their ability to compete with other stable structures. The precise characterization of local minima on the potential energy surface from IR spectroscopy constitutes an acute assessment for the state-of-the-art quantum mechanical calculations also presented. The observation of different types of beta-turns depending upon the residue order within the sequence is found to be consistent with the residue propensities in beta-turns of proteins, which suggests that the prevalence of glycine in type II and II' turns stems essentially from an energetic origin, already at play under isolated conditions.

Process evaluation of the Hunter Illawarra Kids Challenge Using Parent Support study: a multisite randomized controlled trial for the management of child obesity.

PubMed

Jones, Rachel A; Warren, Janet M; Okely, Anthony D; Collins, Clare E; Morgan, Philip J; Cliff, Dylan P; Burrows, Tracy; Cleary, Jane; Baur, Louise A

2010-11-01

The purposes of this article are to (a) outline findings from secondary or process outcome data of the Hunter Illawarra Kids Challenge Using Parent Support (HIKCUPS) study and (b) inform the design and development of future research interventions and practice in the management of child obesity. Data were collected by means of facilitator evaluations, independent session observation, attendance records, and parent questionnaires. Internal validity and reliability of the program delivery were high. All parents reported positive changes in their children as a result of the physical activity program, the dietary modification program, or both. Most participants completed the home activities, but more than half reported that finding time to do them was problematic. Facilitator review indicated that future programs should specifically cater to children of similar age or same sex, allow adequate time for explanation of complex nutritional concepts, and use intrinsic motivators for participants. Recommendations for future interventions, specifically the implementation of subsequent HIKCUPS or other multisite effectiveness studies, are detailed.

Spectroscopic evidence of α,α-dichlorobenzyl radical produced by corona discharge of benzotrichloride

NASA Astrophysics Data System (ADS)

Yoon, Young Wook; Chae, Sang Youl; Lim, Manho; Lee, Sang Kuk

2015-08-01

We report spectroscopic observations of the α,α-dichlorobenzyl radical obtained by corona excited supersonic jet expansion using a pinhole-type glass nozzle. Vibronically excited but jet-cooled radicals were generated by corona discharge of the precursor benzotrichloride with a large amount of helium carrier gas, from which the visible vibronic emission spectrum was recorded using a long path monochromator. From an analysis of the spectrum observed, the electronic energy of the D1 → D0 transition and a few vibrational mode frequencies in the ground electronic state were obtained for the α,α-dichlorobenzyl radical by comparing observed frequencies with those obtained by ab initio calculation.

Facebook as a tool for communication, collaboration, and informal knowledge exchange among members of a multisite family health team.

PubMed

Lofters, Aisha K; Slater, Morgan B; Nicholas Angl, Emily; Leung, Fok-Han

2016-01-01

To implement and evaluate a private Facebook group for members of a large Ontario multisite Family Health Team (FHT) to facilitate improved communication and collaboration. Program implementation and subsequent survey of team members. A large multisite FHT in Toronto, Ontario. Health professionals of the FHT. Usage patterns and self-reported perceptions of the Facebook group by team members. At the time of the evaluation survey, the Facebook group had 43 members (37.4% of all FHT members). Activity in the group was never high, and posts by team members who were not among the researchers were infrequent throughout the study period. The content of posts fell into two broad categories: 1) information that might be useful to various team members and 2) questions posed by team members that others might be able to answer. Of the 26 team members (22.6%) who completed the evaluation survey, many reported that they never logged into the Facebook page (16 respondents), and never used it to communicate with team members outside of their own site of practice (19 respondents). Only six respondents reported no concerns with using Facebook as a professional communication tool; the most frequent concerns were regarding personal and patient privacy. The use of social media by health care practitioners is becoming ubiquitous. However, the issues of privacy concerns and determining how to use social media without adding to provider workload must be addressed to make it a useful tool in health care.

The CHARA Array Resolves the 1.1 Day Period Spectroscopic Binary HD 146361, the Shortest Period System Resolved To-Date

NASA Astrophysics Data System (ADS)

Raghavan, Deepak; McAlister, H. A.

2007-12-01

We present a visual orbit for the spectroscopic binary, HD 146361, derived from observations at the CHARA Array's long baseline interferometer. The 26 calibrated visibility measurements obtained during May - July 2007 allow us to determine a full orbital solution and component masses for this known spectroscopic binary. The HD 146361 pair has a circular orbit of nearly equal-mass components with a good quality double-lined spectroscopic orbit (Dave Latham, private communication). We have adopted the well-constrained spectroscopic orbital elements and fit the angular semi-major axis, inclination, and longitude of nodes to the binary visibility curve equations. Using these elements and the Hipparcos parallax of 46.11 ± 0.98 mas, we obtain component masses of 1.046 ± 0.084 Msol and 1.000 ± 0.080 Msol. We have planned further observations of this system to reduce the mass uncertainties and may present an updated result at the meeting. This is the shortest period spectroscopic binary resolved as of yet with an interferometer. This work is being done in the context of Raghavan's thesis project, which is a survey of solar-type stars in the solar neighborhood. By completing this survey, we hope to build a comprehensive view of the environments around solar-type stars and improve our understanding of their habitats by analyzing their companions of all types - stars, brown dwarfs, and planets. We have chosen an unbiased, volume-limited sample of 455 primary stars as representatives of the solar-type stars in our Galaxy. Our effort is a modern update to the seminal work of Duquennoy & Mayor (1991) and will contribute to the broader subjects of stellar evolution and planetary system formation, evolution, and stability. Research at the CHARA Array is supported by the College of Arts and Sciences at Georgia State University and by the National Science Foundation through NSF Grant AST 0606958.

The Dark Energy Spectroscopic Instrument (DESI)

NASA Astrophysics Data System (ADS)

Flaugher, Brenna; Bebek, Chris

2014-07-01

The Dark Energy Spectroscopic Instrument (DESI) is a Stage IV ground-based dark energy experiment that will study baryon acoustic oscillations (BAO) and the growth of structure through redshift-space distortions with a wide-area galaxy and quasar spectroscopic redshift survey. The DESI instrument consists of a new wide-field (3.2 deg. linear field of view) corrector plus a multi-object spectrometer with up to 5000 robotically positioned optical fibers and will be installed at prime focus on the Mayall 4m telescope at Kitt Peak, Arizona. The fibers feed 10 three-arm spectrographs producing spectra that cover a wavelength range from 360-980 nm and have resolution of 2000-5500 depending on the wavelength. The DESI instrument is designed for a 14,000 sq. deg. multi-year survey of targets that trace the evolution of dark energy out to redshift 3.5 using the redshifts of luminous red galaxies (LRGs), emission line galaxies (ELGs) and quasars. DESI is the successor to the successful Stage-III BOSS spectroscopic redshift survey and complements imaging surveys such as the Stage-III Dark Energy Survey (DES, currently operating) and the Stage-IV Large Synoptic Survey Telescope (LSST, planned start early in the next decade).

Search for spectroscopical signatures of transiting HD 209458b's exosphere

NASA Astrophysics Data System (ADS)

Moutou, C.; Coustenis, A.; Schneider, J.; St Gilles, R.; Mayor, M.; Queloz, D.; Kaufer, A.

2001-05-01

Following recent attempts to detect the exosphere of the extra-solar planet 51 Pegb in the infrared (Coustenis et al. \\cite{cou97}, \\cite{cou98}; Rauer et al. \\cite{rau00a}), we discuss here a search for optical spectroscopic signatures from a gaseous extended envelope (called exosphere) surrounding the planet HD 209458b. This planet has a demonstrated photometric transit (Charbonneau et al. \\cite{cha00a}; Henry et al. \\cite{hen00}), thus offering an increased probability for the spectroscopic detection of such an envelope. Therefore it is the best known candidate for probing the exospheric composition of a giant planet, orbiting a Sun-like star at a short distance. The observations were performed with UVES at the VLT and cover most of the 328-669 nm range. We did not detect HD 209458b's exosphere at a level of 1%, a value close to the predictions. We discuss here the first results obtained and their limitations, as well as future prospective. Based on public data from the UVES Commissioning at the ESO 8.2~m Kueyen telescope operated on Paranal Observatory, Chile.

Multisite effectiveness trials of treatments for substance abuse and co-occurring problems: have we chosen the best designs?

PubMed

Nunes, Edward V; Ball, Samuel; Booth, Robert; Brigham, Gregory; Calsyn, Donald A; Carroll, Kathleen; Feaster, Daniel J; Hien, Denise; Hubbard, Robert L; Ling, Walter; Petry, Nancy M; Rotrosen, John; Selzer, Jeffrey; Stitzer, Maxine; Tross, Susan; Wakim, Paul; Winhusen, Theresa; Woody, George

2010-06-01

Multisite effectiveness trials such as those carried out in the National Drug Abuse Treatment Clinical Trials Network (CTN) are a critical step in the development and dissemination of evidence-based treatments because they address how such treatments perform in real-world clinical settings. As Brigham et al. summarized in a recent article (G. S. Brigham, D. J. Feaster, P. G. Wakim, & C. L. Dempsey C. L., 2009), several possible experimental designs may be chosen for such effectiveness trials. These include (a) a new treatment intervention (Tx) is compared to an existing mode of community based treatment as usual (TAU): Tx versus TAU; (b) a new intervention is added to TAU and compared to TAU alone: Tx + TAU versus TAU; or (c) a new intervention is added to TAU and compared to a control condition added to TAU: Tx + TAU versus control + TAU. Each of these designs addresses a different question and has different potential strengths and weaknesses. As of December 2009, the primary outcome paper had been published for 16 of the multisite randomized clinical trials conducted in the CTN, testing various treatments for drug abuse, HIV risk behavior, or related problems. This paper systematically examines, for each of the completed trials, the experimental design type chosen and its original rationale, the main findings of the trial, and the strengths and weaknesses of the design in hindsight. Based on this review, recommendations are generated to inform the design of future effectiveness trials on treatments for substance abuse, HIV risk, and other behavioral health problems.

Spectroscopic properties and STM images of carbon nanotubes

NASA Astrophysics Data System (ADS)

Rubio, A.

We present a theoretical study of the role of the local environment in the electronic properties of carbon nanotubes: isolated single- and multi-wall nanotubes, nanotube ropes, tubes supported on gold and cut to finite length. Interaction with the substrate or with other tubes does not alter the scanning tunneling microscopy patterns (STM) observed for isolated tubes. A finite-length nanotube shows standing-wave patterns that can be completely characterized by a set of four different three-dimensional shapes. These patterns are understood in terms of a simple π-electron tight-binding (TB) model. STM-topographic images of topological defects ani (pentagon/heptagon pair) and tube caps have also been studied. In both cases the image obtained depends on the sign of the applied voltage and can be described in terms of the previous catalog of STM images (interference between electronic waves scattered by the defect). We have also computed the electronic density of states for isolated tubes with different chiralities and radii, confirming a correlation between the peak structure in the DOS and nanotube diameter. However, the metallic plateau in the DOS also depends on the nanotube chirality. Furthermore the conduction an valence band structures are not fully symmetrical to one another. This anisotropy shows up in the DOS and indicates the limitations of the π-TB model in describing spectroscopic data. In contrast to STM images, here the interaction with the substrate does modify the energy levels of the nanotube. We observe opening of small pseudogaps around the Fermi level and broadening of the sharp van Hove singularities of the isolated single-walled nanotubes that can be used to extract useful information about the tube structure and bonding. The combination of STM and spectroscopic studies provides a new way to address the electronic and structural properties of carbon and composite nanotubes.

Solar flares observed simultaneously with SphinX, GOES and RHESSI

NASA Astrophysics Data System (ADS)

Mrozek, Tomasz; Gburek, Szymon; Siarkowski, Marek; Sylwester, Barbara; Sylwester, Janusz; Kępa, Anna; Gryciuk, Magdalena

2013-07-01

In February 2009, during recent deepest solar minimum, Polish Solar Photometer in X-rays (SphinX) begun observations of the Sun in the energy range of 1.2-15 keV. SphinX was almost 100 times more sensitive than GOES X-ray Sensors. The silicon PIN diode detectors used in the experiment were carefully calibrated on the ground using Synchrotron Radiation Source BESSY II. The SphinX energy range overlaps with the Ramaty High Energy Solar Spectroscopic Imager (RHESSI) energy range. The instrument provided us with observations of hundreds of very small flares and X-ray brightenings. We have chosen a group of solar flares observed simultaneously with GOES, SphinX and RHESSI and performed spectroscopic analysis of observations wherever possible. The analysis of thermal part of the spectra showed that SphinX is a very sensitive complementary observatory for RHESSI and GOES.

Coordination and management of multicenter clinical studies in trauma: Experience from the PRospective Observational Multicenter Major Trauma Transfusion (PROMMTT) Study

PubMed Central

Rahbar, Mohammad H.; Fox, Erin E.; del Junco, Deborah J.; Cotton, Bryan A.; Podbielski, Jeanette M.; Matijevic, Nena; Cohen, Mitchell J.; Schreiber, Martin A.; Zhang, Jiajie; Mirhaji, Parsa; Duran, Sarah; Reynolds, Robert J.; Benjamin-Garner, Ruby; Holcomb, John B.

2011-01-01

Aim Early death due to hemorrhage is a major consequence of traumatic injury. Transfusion practices differ among hospitals and it is unknown which transfusion practices improve survival. This report describes the experience of the PRospective Observational Multicenter Major Trauma Transfusion (PROMMTT) Study Data Coordination Center in designing and coordinating a study to examine transfusion practices at ten Level 1 trauma centers in the U.S. Methods PROMMTT was a multisite prospective observational study of severely injured transfused trauma patients. The clinical sites collected real-time information on the timing and amounts of blood product infusions as well as colloids and crystalloids, vital signs, initial diagnostic and clinical laboratory tests, life saving interventions and other clinical care data. Results Between July 2009 and October 2010, PROMMTT screened 12,561 trauma admissions and enrolled 1,245 patients who received one or more blood transfusions within 6 hours of ED admission. A total of 297 massive transfusions were observed over the course of the study at a combined rate of 5.0 massive transfusion patients/week. Conclusion PROMMTT is the first multisite study to collect real-time prospective data on trauma patients requiring transfusion. Support from the Department of Defense and collaborative expertise from the ten participating centers helped to demonstrate the feasibility of prospective trauma transfusion studies. The observational data collected from this study will be an invaluable resource for research in trauma surgery and it will guide the design and conduct of future randomized trials. PMID:22001613

Spectroscopic Classification of Nine Optical Transients with the 2.5-m du Pont Telescope

NASA Astrophysics Data System (ADS)

Bose, Subhash; Holoien, Tom; Prieto, Jose L.; Dong, Subo; Chen, P.; Stanek, K. Z.

2018-04-01

We report spectroscopic observations and classifications of optical transients using the du Pont 2.5-m telescope (+ WFCCD) at Las Campanas Observatory. Targets were discovered by the All-Sky Automated Survey for Supernovae (ASAS-SN, Shappee et al. 2014) (ATel #11391, ATel #11343, ATel #11459), Gaia Alerts (http://gsaweb.ast.cam.ac.uk/alerts/alertsindex) and A. Rest et al. (for 2018agk).

Spectroscopic diagnostics of organic chemistry in the protostellar environment

NASA Technical Reports Server (NTRS)

Charnley, S. B.; Ehrenfreund, P.; Kuan, Y. J.

2001-01-01

A combination of astronomical observations, laboratory studies, and theoretical modelling is necessary to determine the organic chemistry of dense molecular clouds. We present spectroscopic evidence for the composition and evolution of organic molecules in protostellar environments. The principal reaction pathways to complex molecule formation by catalysis on dust grains and by reactions in the interstellar gas are described. Protostellar cores, where warming of dust has induced evaporation of icy grain mantles, are excellent sites in which to study the interaction between gas phase and grain-surface chemistries. We investigate the link between organics that are observed as direct products of grain surface reactions and those which are formed by secondary gas phase reactions of evaporated surface products. Theory predicts observable correlations between specific interstellar molecules, and also which new organics are viable for detection. We discuss recent infrared observations obtained with the Infrared Space Observatory, laboratory studies of organic molecules, theories of molecule formation, and summarise recent radioastronomical searches for various complex molecules such as ethers, azaheterocyclic compounds, and amino acids.

Multi-site Study of Diffusion Metric Variability: Characterizing the Effects of Site, Vendor, Field Strength, and Echo Time using the Histogram Distance.

PubMed

Helmer, K G; Chou, M-C; Preciado, R I; Gimi, B; Rollins, N K; Song, A; Turner, J; Mori, S

2016-02-27

MRI-based multi-site trials now routinely include some form of diffusion-weighted imaging (DWI) in their protocol. These studies can include data originating from scanners built by different vendors, each with their own set of unique protocol restrictions, including restrictions on the number of available gradient directions, whether an externally-generated list of gradient directions can be used, and restrictions on the echo time (TE). One challenge of multi-site studies is to create a common imaging protocol that will result in a reliable and accurate set of diffusion metrics. The present study describes the effect of site, scanner vendor, field strength, and TE on two common metrics: the first moment of the diffusion tensor field (mean diffusivity, MD), and the fractional anisotropy (FA). We have shown in earlier work that ROI metrics and the mean of MD and FA histograms are not sufficiently sensitive for use in site characterization. Here we use the distance between whole brain histograms of FA and MD to investigate within- and between-site effects. We concluded that the variability of DTI metrics due to site, vendor, field strength, and echo time could influence the results in multi-center trials and that histogram distance is sensitive metrics for each of these variables.

Multi-site Study of Diffusion Metric Variability: Characterizing the Effects of Site, Vendor, Field Strength, and Echo Time using the Histogram Distance

PubMed Central

Helmer, K. G.; Chou, M-C.; Preciado, R. I.; Gimi, B.; Rollins, N. K.; Song, A.; Turner, J.; Mori, S.

2016-01-01

MRI-based multi-site trials now routinely include some form of diffusion-weighted imaging (DWI) in their protocol. These studies can include data originating from scanners built by different vendors, each with their own set of unique protocol restrictions, including restrictions on the number of available gradient directions, whether an externally-generated list of gradient directions can be used, and restrictions on the echo time (TE). One challenge of multi-site studies is to create a common imaging protocol that will result in a reliable and accurate set of diffusion metrics. The present study describes the effect of site, scanner vendor, field strength, and TE on two common metrics: the first moment of the diffusion tensor field (mean diffusivity, MD), and the fractional anisotropy (FA). We have shown in earlier work that ROI metrics and the mean of MD and FA histograms are not sufficiently sensitive for use in site characterization. Here we use the distance between whole brain histograms of FA and MD to investigate within- and between-site effects. We concluded that the variability of DTI metrics due to site, vendor, field strength, and echo time could influence the results in multi-center trials and that histogram distance is sensitive metrics for each of these variables. PMID:27350723

Unbiased clustering estimation in the presence of missing observations

NASA Astrophysics Data System (ADS)

Bianchi, Davide; Percival, Will J.

2017-11-01

In order to be efficient, spectroscopic galaxy redshift surveys do not obtain redshifts for all galaxies in the population targeted. The missing galaxies are often clustered, commonly leading to a lower proportion of successful observations in dense regions. One example is the close-pair issue for SDSS spectroscopic galaxy surveys, which have a deficit of pairs of observed galaxies with angular separation closer than the hardware limit on placing neighbouring fibres. Spatially clustered missing observations will exist in the next generations of surveys. Various schemes have previously been suggested to mitigate these effects, but none works for all situations. We argue that the solution is to link the missing galaxies to those observed with statistically equivalent clustering properties, and that the best way to do this is to rerun the targeting algorithm, varying the angular position of the observations. Provided that every pair has a non-zero probability of being observed in one realization of the algorithm, then a pair-upweighting scheme linking targets to successful observations, can correct these issues. We present such a scheme, and demonstrate its validity using realizations of an idealized simple survey strategy.

Spectroscopic monitoring of the BL Lac object AO 0235+164

NASA Astrophysics Data System (ADS)

Raiteri, C. M.; Villata, M.; Capetti, A.; Heidt, J.; Arnaboldi, M.; Magazzù, A.

2007-03-01

Aims:Spectroscopic monitoring of BL Lac objects is a difficult task that nonetheless can provide important information on the different components of the active galactic nucleus. Methods: We performed optical spectroscopic monitoring of the BL Lac object AO 0235+164 (z=0.94) with the VLT and TNG telescopes from Aug. 2003 to Dec. 2004, during an extended WEBT campaign. The flux of this source is both contaminated and absorbed by a foreground galactic system at z=0.524, the stars of which can act as gravitational micro-lenses. Results: In this period the object was in an optically faint, though variable state, and a broad Mg II emission line was visible at all epochs. The spectroscopic analysis reveals an overall variation in the Mg II line flux of a factor 1.9, while the corresponding continuum flux density changed by a factor 4.3. Most likely, the photoionising radiation can be identified with the emission component that was earlier recognised to be present as a UV-soft-X-ray bump in the source spectral energy distribution and that is visible in the optical domain only in very faint optical states. We estimate an upper limit to the broad line region (BLR) size of a few light months from the historical minimum brightness level; from this we infer the maximum amplification of the Mg II line predicted by the microlensing scenario. Conclusions: .Unless we have strongly overestimated the size of the BLR, only very massive stars could significantly magnify the broad Mg II emission line, but the time scale of variations due to these (rare) events would be of several years. In contrast, the continuum flux, coming from much smaller emission regions in the jet, could be affected by microlensing from the more plausible MACHO deflectors, with variability time scales of the order of some months. Based on observations collected at the European Southern Observatory, Chile (ESO Programme 71.A-0174), and on observations made with the Italian Telescopio Nazionale Galileo (TNG

Follow-up spectroscopic observations of HD 107148 B: A new white dwarf companion of an exoplanet host star

NASA Astrophysics Data System (ADS)

Mugrauer, M.; Dinçel, B.

2016-06-01

We report on our follow-up spectroscopy of HD 1071478 B, a recently detected faint co-moving companion of the exoplanet host star HD 107148 A. The companion is separated from its primary star by about 35 arcsec (or 1790 AU of projected separation) and its optical and near infrared photometry is consistent with a white dwarf, located at the distance of HD 107148 A. In order to confirm the white dwarf nature of the co-moving companion, we obtained follow-up spectroscopic observations of HD 107148 B with CAFOS at the CAHA 2.2 m telescope. According to our CAFOS spectroscopy HD 107148 B is a DA white dwarf with an effective temperature in the range between 5900 and 6400 K. The properties of HD 107148 B can further be constrained with the derived effective temperature and the known visual and infrared photometry of the companion, using evolutionary models of DA white dwarfs. We obtain for HD 107148 B a mass of 0.56±0.05 M_⊙, a luminosity of (2.0±0.2)×10-4 L_⊙, log g [cm s-2])=7.95±0.09, and a cooling age of 2100±270 Myr. With its white dwarf companion the exoplanet host star HD 107148 A forms an evolved stellar system, which hosts at least one exoplanet. So far, only few of these evolved systems are known, which represent only about 5 % of all known exoplanet host multiple stellar systems. HD 107148 B is the second confirmed white dwarf companion of an exoplanet host star with a projected separation to its primary star of more than 1000 AU. Based on observations collected at the Centro Astronómico Hispano Alemán (CAHA) at Calar Alto, operated jointly by the Max-Planck Institut für Astronomie and the Instituto de Astrofísica de Andalucía (CSIC).

Velocity Segregation and Systematic Biases In Velocity Dispersion Estimates with the SPT-GMOS Spectroscopic Survey

NASA Astrophysics Data System (ADS)

Bayliss, Matthew. B.; Zengo, Kyle; Ruel, Jonathan; Benson, Bradford A.; Bleem, Lindsey E.; Bocquet, Sebastian; Bulbul, Esra; Brodwin, Mark; Capasso, Raffaella; Chiu, I.-non; McDonald, Michael; Rapetti, David; Saro, Alex; Stalder, Brian; Stark, Antony A.; Strazzullo, Veronica; Stubbs, Christopher W.; Zenteno, Alfredo

2017-03-01

The velocity distribution of galaxies in clusters is not universal; rather, galaxies are segregated according to their spectral type and relative luminosity. We examine the velocity distributions of different populations of galaxies within 89 Sunyaev Zel’dovich (SZ) selected galaxy clusters spanning 0.28< z< 1.08. Our sample is primarily draw from the SPT-GMOS spectroscopic survey, supplemented by additional published spectroscopy, resulting in a final spectroscopic sample of 4148 galaxy spectra—2868 cluster members. The velocity dispersion of star-forming cluster galaxies is 17 ± 4% greater than that of passive cluster galaxies, and the velocity dispersion of bright (m< {m}* -0.5) cluster galaxies is 11 ± 4% lower than the velocity dispersion of our total member population. We find good agreement with simulations regarding the shape of the relationship between the measured velocity dispersion and the fraction of passive versus star-forming galaxies used to measure it, but we find a small offset between this relationship as measured in data and simulations, which suggests that our dispersions are systematically low by as much as 3% relative to simulations. We argue that this offset could be interpreted as a measurement of the effective velocity bias that describes the ratio of our observed velocity dispersions and the intrinsic velocity dispersion of dark matter particles in a published simulation result. Measuring velocity bias in this way suggests that large spectroscopic surveys can improve dispersion-based mass-observable scaling relations for cosmology even in the face of velocity biases, by quantifying and ultimately calibrating them out.

Review: Observations of recent comets, ion tails

NASA Technical Reports Server (NTRS)

Brandt, J. C.

1976-01-01

Photographic plates of the moving structures in the cometary tail are examined. Several divergent explanations for the case of comet Kohoutek are presented. It is suggested that these hypotheses be tested by observing the motion of the material spectroscopically by means of the Doppler effect.

The spectroscopic search for the trace aerosols in the planetary atmospheres - the results of numerical simulations

NASA Astrophysics Data System (ADS)

Blecka, Maria I.

2010-05-01

The passive remote spectrometric methods are important in examinations the atmospheres of planets. The radiance spectra inform us about values of thermodynamical parameters and composition of the atmospheres and surfaces. The spectral technology can be useful in detection of the trace aerosols like biological substances (if present) in the environments of the planets. We discuss here some of the aspects related to the spectroscopic search for the aerosols and dust in planetary atmospheres. Possibility of detection and identifications of biological aerosols with a passive InfraRed spectrometer in an open-air environment is discussed. We present numerically simulated, based on radiative transfer theory, spectroscopic observations of the Earth atmosphere. Laboratory measurements of transmittance of various kinds of aerosols, pollens and bacterias were used in modeling.

Evaluating effective pair and multisite interactions for Ni-Mo system

NASA Astrophysics Data System (ADS)

Banerjee, Rumu H.; Arya, A.; Banerjee, S.

2018-04-01

Cluster expansion (CE) method was used to calculate the energies of various Ni-Mo phases. The clusters comprising of few nearest neighbours can describe any phase of Ni-Mo system by suitable choice of effective pair and multisite interaction parameters (ECI). The ECIs were evaluated in present study by fitting the ground state energies obtained by first principle calculations. The ECIs evaluated for Ni-Mo system were mostly pair clusters followed by triplets and quadruplet clusters with cluster diameters in the range 2.54 - 10.20 Å. The ECI values diminished for multi-body (triplets and quadruplets) clusters as compared to 2-point or pair clusters indicating a good convergence of CE model. With these ECIs the predicted energies of all the Ni-Mo structures across the Mo concentration range 0-100 at% were obtained. The quantitative error in the energies calculated by CE approach and first principle is very small (< 0.026 meV/atom). The appreciable values of 2-point ECIs upto 4th nearest neighbour reveal that two body interactions are dominant in the case of Ni-Mo system. These ECIs are compared with the reported values of compositional dependent effective pair interactions evaluated by first principle as well as by Monte Carlo method.

Spectroscopic study of the optical counterpart to the fast X-ray transient IGR J17544-2619 based on observations at the 1.5-m RTT-150 telescope

NASA Astrophysics Data System (ADS)

Bikmaev, I. F.; Nikolaeva, E. A.; Shimansky, V. V.; Galeev, A. I.; Zhuchkov, R. Ya.; Irtuganov, E. N.; Melnikov, S. S.; Sakhibullin, N. A.; Grebenev, S. A.; Sharipova, L. M.

2017-10-01

We present the results of our long-term photometric and spectroscopic observations at the Russian-Turkish RTT-150 telescope for the optical counterpart to one of the best-known sources, representatives of the class of fast X-ray transients, IGR J17544-2619. Based on our optical data, we have determined for the first time the orbital and physical parameters of the binary system by the methods of Doppler spectroscopy.We have calculated theoretical spectra of the optical counterpart by applying non- LTE corrections for selected lines and obtained the parameters of the stellar atmosphere ( T eff = 33 000 K, log g = 3.85, R = 9.5 R ⊙, and M = 23 M ⊙). The latter suggest that the optical star is not a supergiant as has been thought previously.

Phase-dependent Photometric and Spectroscopic Characterization of the MASTER-Net Optical Transient J212444.87+321738.3: An Oxygen-rich Mira

NASA Astrophysics Data System (ADS)

Ghosh, Supriyo; Mondal, Soumen; Das, Ramkrishna; Banerjee, D. P. K.; Ashok, N. M.; Hambsch, Franz-Josef; Dutta, Somnath

2018-05-01

We describe the time-dependent properties of a new spectroscopically confirmed Mira variable, which was discovered in 2013 as MASTER-Net Optical Transient J212444.87+321738.3 toward the Cygnus constellation. We have performed long-term optical/near-infrared (NIR) photometric and spectroscopic observations to characterize the object. From the optical/NIR light curves, we estimate a variability period of 465 ± 30 days. The wavelength-dependent amplitudes of the observed light curves range from ΔI ∼ 4 mag to ΔK ∼ 1.5 mag. The (J ‑ K) color index varies from 1.78 to 2.62 mag over phases. Interestingly, a phase lag of ∼60 days between optical and NIR light curves is also seen, as in other Miras. Our optical/NIR spectra show molecular features of TiO, VO, CO, and strong water bands that are a typical signature of oxygen-rich Mira. We rule out S- or C-type as ZrO bands at 1.03 and 1.06 μm and C2 band at 1.77 μm are absent. We estimate the effective temperature of the object from the Spectral Energy Distribution, and distance and luminosity from standard Period–Luminosity relations. The optical/NIR spectra display time-dependent atomic and molecular features (e.g., TiO, Na I, Ca I, H2O, CO), as commonly observed in Miras. Such spectroscopic observations are useful for studying pulsation variability in Miras.

Low temperature IR spectroscopic study of torsional vibrations of taurine

NASA Astrophysics Data System (ADS)

Bajaj, Naini; Bhatt, Himal; Vishwakarma, S. R.; Thomas, Susy; Murli, C.; Deo, M. N.

2018-04-01

The hydrogen bonding network in amino acids can give information about the structural stability under varying thermodynamic conditions such as temperature and pressure. We have carried out low temperature IR spectroscopic studies on Taurine, an amino acid with various bio-chemical applications in physiology and synthesis, in order to observe the behaviour of torsional modes, i.e. τ(CSH) and τ(NH3), which are very sensitive to the hydrogen bonding interactions. It was observed that the CSH torsional mode showed splitting at low temperature of nearly 250 K and the bandwidth shows linear temperature dependence, which can be attributed to anharmonicity. Another torsional mode, τ(NH3) showed no splitting, but the bandwidth has non-linear temperature dependence. This can be due to orientational changes at low temperature. These observations are strong evidences for a hydrogen bond reorientation induced phase transition at 250 K.

Ultraviolet Spectroscopic Monitoring of a Tidal Disruption Eventd

NASA Astrophysics Data System (ADS)

Kochanek, Chris

2017-08-01

Tidal disruption events (TDE), where supermassive black holes destroy stars toproduce accretion flares, are of great current observational andtheoretical interest. Here we propose a seven epoch STIS UV spectroscopic movie'' of a UV bright TDE spread over the first 90 days after a rapid TOO trigger. The roughly 15 day cadence is comparable to the expected and observed time scales for kinematic changes in theoptical and UV emission and absorption lines. We will measurethe evolution of UV absorption and emission lines from elements(e.g., C, N, Si) and ionization states/potentials not seen in optical spectra of TDEs, which should help to illuminate theirdynamical evolution. In some cases, the debris from the stellar cores should have significantly enhanced [N/C] abundances due to the CNO cycle, so UV spectra can provide a means of differentiating debris fromthe core and the envelope of the disrupted star. Optically-selectedTDEs are energetically dominated by their UV emission, making itthe wavelength range most needed to understand these fascinatingtransients.

Spectroscopic investigations on oxidized multi-walled carbon nanotubes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Anandhi, C. M. S.; Premkumar, S.; Asath, R. Mohamed

2016-05-06

The pristine multi-walled carbon nanotubes (MWCNTs) were oxidized by the ultrasonication process. The oxidized MWCNTs were characterized by the X-ray diffraction (XRD), ultraviolet–visible (UV-Vis) and Fourier transform -Raman (FT-Raman) spectroscopic techniques. The XRD analysis confirms that the oxidized MWCNTs exist in a hexagonal structure and the sharp XRD peak corresponds to the (002) Bragg’s reflection plane, which indicates that the MWCNTs have higher crystalline nature. The UV-Vis analysis confirms that the MWCNTs functionalized with the carboxylic acid. The red shift was observed corresponds to the D band in the Raman spectrum, which reveals that the reduced disordered graphitic structure ofmore » oxidized MWCNTs. The strong Raman peak was observed at 2563 cm{sup -1} corresponds to the overtone of the D band, which is the characteristic vibrational mode of oxidized MWCNTs. The carboxylic acid functionalization of MWCNTs enhances the dispersibility, which paves the way for potential applications in the field of biosensors and targeted drug delivery.« less

Spectroscopic analysis of radiation-generated changes in tensile properties of a polyetherimide film

NASA Technical Reports Server (NTRS)

Long, E. R., Jr.; Long, S. A. T.

1985-01-01

The effects of electron radiation on Ultem, a polyetherimide were studied for doses from 2 x 10 to the 9th power to 6 x 10 to the 9th power rad. Specimens were studied for tensile property testing and for electron paramagnetic resonance and infrared spectroscopic measurements of molecular structure. A Faraday cup design and a method for remote temperature measurement were developed. The spectroscopic data show that radiation caused dehydrogenation of methyl groups, rupture of main-chain ether linkage, and opening of imide rings, all to form radicals and indicate that the so-formed atomic hydrogen attached to phenyl radicals, but not to phenoxyl radicals, which would have formed hydroxyls. The observed decays of the radiation-generated phenoxyl, gem-dimethyl, and carbonyl radicals were interpreted as a combining of the radicals to form crosslinking. This crosslinking is the probable cause of the major reduction in the elongation of the tensile specimens after irradiation. Subsequent classical solubility tests indicate that the irradiation caused massive crosslinking.

The Galactic O-Star Spectroscopic Survey (GOSSS): new results from the southern stars

NASA Astrophysics Data System (ADS)

Sota, A.; Maíz Apellániz, J.; Barbá, R. H.; Walborn, N. R.; Alfaro, E. J.; Gamen, R. C.; Morrell, N. I.; Arias, J. I.; Penadés Ordaz, M.

2013-05-01

The Galactic O-Star Spectroscopic Survey (GOSSS) is a project that will observe all known Galactic O stars with B < 14 in the blue-violet part of the spectrum with R ˜ 3000. It is based on v2.0 of the the most complete Galactic O star catalog with accurate spectral types (Maíz Apellániz et al. 2004, ApJS, 151, 103; Sota et al. 2008, RevMexAA Conf. Series, 33, 55) that we have recently compiled. We have completed the first part of the main project and recently published the first articles (Walborn et al. 2010, ApJ, 711, 143; Walborn et al. 2011, AJ, 142, 150; Sota et al. 2011, ApJS, 193, 24). GOSSS is part of a bigger project with the next companion surveys: High resolution spectroscopic surveys: OWN, IACOB, IACOB-sweG, NoMaDS, CAFÉ-BEANS High resolution imaging surveys: Astralux, Astralux Sur.

Preparation of the COROT mission: fundamental stellar parameters from photometric and spectroscopic analyses of target candidates

NASA Astrophysics Data System (ADS)

Lastennet, E.; Lignières, F.; Buser, R.; Lejeune, T.; Lüftinger, T.; Cuisinier, F.; van't Veer-Menneret, C.

2001-09-01

We present a sample of 9 nearby F-type stars with detailed spectroscopic analyses to investigate the Basel Stellar Library (BaSeL) in two photometric systems simultaneously, Johnson UBV and Stromgren uvby. The sample corresponds to potential targets of the central seismology programme of the COROT (COnvection & ROtation) space experiment, which have been recently observed at Observatoire de Haute-Provence (OHP, France). The atmospheric parameters Teff, [Fe/H], and log g obtained from the BaSeL models are compared with spectroscopic determinations as well as with results of other photometric calibrations (the TEMPLOGG method and the catalogue of Marsakov & Shevelev, 1995). Moreover, new rotational velocity determinations are also derived from the spectroscopic analysis and compared with previous results compiled in the SIMBAD database. For a careful interpretation of the BaSeL solutions, we computed confidence regions around the best chi^2-estimates and projected them on Teff-[Fe/H], Teff-log g, and log g-[Fe/H] diagrams. In order to simultaneously and accurately determine the stellar parameters Teff, [Fe/H] and log g, we suggest to use the combination of the synthetic BaSeL indices B-V, U-B and b-y (rather than the full photometric information available for these stars: B-V, U-B, b-y, m1 and c1) and we present complete results in 3 different diagrams, along with the results of other methods (photometric and spectroscopic). All the methods presented give consistent solutions, and the agreement between TEMPLOGG and BaSeL for the hottest stars of the sample could be especially useful in view of the well-known difficulty of spectroscopic determinations for fast rotating stars. Finally, we present current and future developments of the BaSeL models for a systematic application to all the COROT targets.

Preparation of the COROT mission: fundamental stellar parameters from photometric and spectroscopic analyses of target candidates

NASA Astrophysics Data System (ADS)

Lastennet, E.; Lignières, F.; Buser, R.; Lejeune, T.; Lüftinger, T.; Cuisinier, F.; van't Veer-Menneret, C.

2001-12-01

We present a sample of 9 nearby F-type stars with detailed spectroscopic analyses to investigate the Basel Stellar Library (BaSeL) in two photometric systems simultaneously, Johnson UBV and Strömgren uvby. The sample corresponds to potential targets of the central seismology programme of the COROT (COnvection & ROtation) space experiment, which have been recently observed at Observatoire de Haute-Provence (OHP, France). The atmospheric parameters Teff, [Fe/H], and log g obtained from the BaSeL models are compared with spectroscopic determinations as well as with results of other photometric calibrations (the TEMPLOGG method and the catalogue of Marsakov & Shevelev, 1995). Moreover, new rotational velocity determinations are also derived from the spectroscopic analysis and compared with previous results compiled in the SIMBAD database. For a careful interpretation of the BaSeL solutions, we computed confidence regions around the best χ2-estimates and projected them on Teff-[Fe/H], Teff-log g, and log g-[Fe/H] diagrams. In order to simultaneously and accurately determine the stellar parameters Teff, [Fe/H] and log g, we suggest to use the combination of the synthetic BaSeL indices B-V, U-B and b-y (rather than the full photometric information available for these stars: B-V, U-B, b-y, m1 and c1) and we present complete results in 3 different diagrams, along with the results of other methods (photometric and spectroscopic). All the methods presented give consistent solutions, and the agreement between TEMPLOGG and BaSeL for the hottest stars of the sample could be especially useful in view of the well-known difficulty of spectroscopic determinations for fast rotating stars. Finally, we present current and future developments of the BaSeL models for a systematic application to all the COROT targets.

High-energy solar flare observations at the Y2K maximum

NASA Astrophysics Data System (ADS)

Emslie, A. Gordon

2000-04-01

Solar flares afford an opportunity to observe processes associated with the acceleration and propagation of high-energy particles at a level of detail not accessible in any other astrophysical source. I will review some key results from previous high-energy solar flare observations, including those from the Compton Gamma-Ray Observatory, and the problems that they pose for our understanding of energy release and particle acceleration processes in the astrophysical environment. I will then discuss a program of high-energy observations to be carried out during the upcoming 2000-2001 solar maximum that is aimed at addressing and resolving these issues. A key element in this observational program is the High Energy Solar Spectroscopic Imager (HESSI) spacecraft, which will provide imaging spectroscopic observations with spatial, temporal, and energy resolutions commensurate with the physical processes believed to be operating, and will in addition provide the first true gamma-ray spectroscopy of an astrophysical source. .

Rocket ultraviolet observations of Comet Halley

NASA Technical Reports Server (NTRS)

Carruthers, George R.; Mccoy, Robert P.; Woods, Thomas N.; Feldman, Paul D.; Opal, Chet B.

1987-01-01

Ultraviolet observations of Comet Halley have been obtained in February and March, 1986 with two instrument payloads, one with the Faint Object Telescope and one with a direct imaging electrographic Schmidt camera and an objective grating spectrograph. The observations include spectroscopic imagery in the 1200-200 A wavelength range and imagery of the comet in hydrogen Lyman-alpha (1216 A) radiation. The present observations have been reduced to intensity contour plots in the different emission wavelengths, and production rates are given for the emitting species H, C, O, S, and CO.

Repeated assessment of orthotopic glioma pO(2) by multi-site EPR oximetry: a technique with the potential to guide therapeutic optimization by repeated measurements of oxygen.

PubMed

Khan, Nadeem; Mupparaju, Sriram; Hou, Huagang; Williams, Benjamin B; Swartz, Harold

2012-02-15

Tumor hypoxia plays a vital role in therapeutic resistance. Consequently, measurements of tumor pO(2) could be used to optimize the outcome of oxygen-dependent therapies, such as, chemoradiation. However, the potential optimizations are restricted by the lack of methods to repeatedly and quantitatively assess tumor pO(2) during therapies, particularly in gliomas. We describe the procedures for repeated measurements of orthotopic glioma pO(2) by multi-site electron paramagnetic resonance (EPR) oximetry. This oximetry approach provides simultaneous measurements of pO(2) at more than one site in the glioma and contralateral cerebral tissue. The pO(2) of intracerebral 9L, C6, F98 and U251 tumors, as well as contralateral brain, were measured repeatedly for five consecutive days. The 9L glioma was well oxygenated with pO(2) of 27-36 mm Hg, while C6, F98 and U251 glioma were hypoxic with pO(2) of 7-12mm Hg. The potential of multi-site EPR oximetry to assess temporal changes in tissue pO(2) was investigated in rats breathing 100% O(2). A significant increase in F98 tumor and contralateral brain pO(2) was observed on day 1 and day 2, however, glioma oxygenation declined on subsequent days. In conclusion, EPR oximetry provides the capability to repeatedly assess temporal changes in orthotopic glioma pO(2). This information could be used to test and optimize the methods being developed to modulate tumor hypoxia. Furthermore, EPR oximetry could be potentially used to enhance the outcome of chemoradiation by scheduling treatments at times of increase in glioma pO(2). Copyright © 2011 Elsevier B.V. All rights reserved.

The Maunakea Spectroscopic Explorer

NASA Astrophysics Data System (ADS)

Venn, Kim; Starkenburg, Else; Martin, Nicolas; Kielty, Collin; Youakim, Kris; Arnetsen, Anke

2018-06-01

The Maunakea Spectroscopic Explorer (MSE) is an ambitious project to transform the Canada-France-Hawaii 3.6-metre telescope into an 11.25-metre facility dedicated to wide field multi-object spectroscopy. Following a successful conceptual design review of ten subsystems and the systems-level review in January 2018, MSE is preparing to move into the Preliminary Design Phase. MSE will simultaneously deploy over 3000 fibers that feed low/medium resolution spectrometers and 1000 fibers that feed high-resolution (R~40,000) spectrometers. This design is expected to revolutionize astrophysical studies requiring large spectroscopic datasets: i.e., reconstructing the Milky Way's formation history through the chemical tagging of stars, searches for the effects of dark matter on stellar streams, determination of environmental influences on galaxy formation since cosmic noon, measuring black hole masses through repeat spectroscopy of quasars, follow-up of large samples identified in other surveys (Gaia, LSST, SKA, etc.), and more. MSE will reuse a large fraction of CFHT’s existing facilities while tripling the diameter of the telescope’s primary mirror and increasing the height of the enclosure by only 10%. I will discuss the progress to date and opportunities for partnerships.

Protonated Nitrous Oxide, NNOH(+): Fundamental Vibrational Frequencies and Spectroscopic Constants from Quartic Force Fields

NASA Technical Reports Server (NTRS)

Huang, Xinchuan; Fortenberry, Ryan C.; Lee, Timothy J.

2013-01-01

The interstellar presence of protonated nitrous oxide has been suspected for some time. Using established high-accuracy quantum chemical techniques, spectroscopic constants and fundamental vibrational frequencies are provided for the lower energy O-protonated isomer of this cation and its deuterated isotopologue. The vibrationally-averaged B0 and C0 rotational constants are within 6 MHz of their experimental values and the D(subJ) quartic distortion constants agree with experiment to within 3%. The known gas phase O-H stretch of NNOH(+) is 3330.91 cm(exp-1), and the vibrational configuration interaction computed result is 3330.9 cm(exp-1). Other spectroscopic constants are also provided, as are the rest of the fundamental vibrational frequencies for NNOH(+) and its deuterated isotopologue. This high-accuracy data should serve to better inform future observational or experimental studies of the rovibrational bands of protonated nitrous oxide in the ISM and the laboratory.

The IACOB project. V. Spectroscopic parameters of the O-type stars in the modern grid of standards for spectral classification

NASA Astrophysics Data System (ADS)

Holgado, G.; Simón-Díaz, S.; Barbá, R. H.; Puls, J.; Herrero, A.; Castro, N.; Garcia, M.; Maíz Apellániz, J.; Negueruela, I.; Sabín-Sanjulián, C.

2018-06-01

Context. The IACOB and OWN surveys are two ambitious, complementary observational projects which have made available a large multi-epoch spectroscopic database of optical high resolution spectra of Galactic massive O-type stars. Aims: Our aim is to study the full sample of (more than 350) O stars surveyed by the IACOB and OWN projects. As a first step towards this aim, we have performed the quantitative spectroscopic analysis of a subsample of 128 stars included in the modern grid of O-type standards for spectral classification. The sample comprises stars with spectral types in the range O3-O9.7 and covers all luminosity classes. Methods: We used the semi-automatized IACOB-BROAD and IACOB-GBAT/FASTWIND tools to determine the complete set of spectroscopic parameters that can be obtained from the optical spectrum of O-type stars. A quality flag was assigned to the outcome of the IACOB-GBAT/FASTWIND analysis for each star, based on a visual evaluation of how the synthetic spectrum of the best fitting FASTWIND model reproduces the observed spectrum. We also benefitted from the multi-epoch character of the IACOB and OWN surveys to perform a spectroscopic variability study of the complete sample, providing two different flags for each star accounting for spectroscopic binarity as well as variability of the main wind diagnostic lines. Results: We obtain - for the first time in a homogeneous and complete manner - the full set of spectroscopic parameters of the "anchors" of the spectral classification system in the O star domain. We provide a general overview of the stellar and wind parameters of this reference sample, as well as updated recipes for the SpT-Teff and SpT-log g calibrations for Galactic O-type stars. We also propose a distance-independent test for the wind-momentum luminosity relationship. We evaluate the reliability of our semi-automatized analysis strategy using a subsample of 40 stars extensively studied in the literature, and find a fairly good agreement

Spectroscopic Chemical Analysis Methods and Apparatus

NASA Technical Reports Server (NTRS)

Hug, William F. (Inventor); Lane, Arthur L. (Inventor); Bhartia, Rohit (Inventor); Reid, Ray D. (Inventor)

2017-01-01

Spectroscopic chemical analysis methods and apparatus are disclosed which employ deep ultraviolet (e.g. in the 200 nm to 300 nm spectral range) electron beam pumped wide bandgap semiconductor lasers, incoherent wide bandgap semiconductor light emitting devices, and hollow cathode metal ion lasers to perform non-contact, non-invasive detection of unknown chemical analytes. These deep ultraviolet sources enable dramatic size, weight and power consumption reductions of chemical analysis instruments. In some embodiments, Raman spectroscopic detection methods and apparatus use ultra-narrow-band angle tuning filters, acousto-optic tuning filters, and temperature tuned filters to enable ultra-miniature analyzers for chemical identification. In some embodiments Raman analysis is conducted along with photoluminescence spectroscopy (i.e. fluorescence and/or phosphorescence spectroscopy) to provide high levels of sensitivity and specificity in the same instrument.

Spectroscopic Chemical Analysis Methods and Apparatus

NASA Technical Reports Server (NTRS)

Hug, William F. (Inventor); Lane, Arthur L. (Inventor); Reid, Ray D. (Inventor); Bhartia, Rohit (Inventor)

2018-01-01

Spectroscopic chemical analysis methods and apparatus are disclosed which employ deep ultraviolet (e.g. in the 200 nm to 300 nm spectral range) electron beam pumped wide bandgap semiconductor lasers, incoherent wide bandgap semiconductor light emitting devices, and hollow cathode metal ion lasers to perform non-contact, non-invasive detection of unknown chemical analytes. These deep ultraviolet sources enable dramatic size, weight and power consumption reductions of chemical analysis instruments. In some embodiments, Raman spectroscopic detection methods and apparatus use ultra-narrow-band angle tuning filters, acousto-optic tuning filters, and temperature tuned filters to enable ultra-miniature analyzers for chemical identification. In some embodiments Raman analysis is conducted along with photoluminescence spectroscopy (i.e. fluorescence and/or phosphorescence spectroscopy) to provide high levels of sensitivity and specificity in the same instrument.

Implementation of an integrated computerized prescriber order-entry system for chemotherapy in a multisite safety-net health system.

PubMed

Chung, Clement; Patel, Shital; Lee, Rosetta; Fu, Lily; Reilly, Sean; Ho, Tuyet; Lionetti, Jason; George, Michael D; Taylor, Pam

2018-03-15

The development of a computerized prescriber order-entry (CPOE) system for chemotherapy in a multisite safety-net health system and the challenges to its successful implementation are described. Before CPOE for chemotherapy was first implemented and embedded in the electronic medical record system of Harris Health System (HHS), pharmacy personnel relied on regimen-specific preprinted order sets. However, due to differences in practice styles and workflow logistics, the paper orders across the 3 facilities were mostly site specific, with varying clinical content. Many of these order sets had not been approved by the oncology subcommittee. In addition, disparities in clinical knowledge and lack of communication contributed to inconsistencies in order set development. Led by medical directors from medical oncology departments at the 3 facilities, pharmacy administrators, and information technology representatives, HHS committed resources to supporting the adoption and use of a CPOE system for chemotherapy. Five practical lessons of broad applicability have been learned: engagement of interprofessional stakeholders, optimization of workflow before CPOE implementation, requirement of verification tool for CPOE, consolidation of protocols, and commitment to ongoing training and support. Evaluation of the CPOE system demonstrated a systemwide reduction in medication errors by 75% ( p < 0.05). Satisfaction with the CPOE system varied among sites and was unchanged institutionwide 6 months after the CPOE implementation. The development and implementation of CPOE for chemotherapy at a multisite safety-net health system created opportunities to optimize patient care and reduce variations through interprofessional collaborations. Initial evaluation suggested that CPOE reduced the medication-order error rate and improved user satisfaction in 1 of 3 facilities. Copyright © 2018 by the American Society of Health-System Pharmacists, Inc. All rights reserved.

The Ninth Data Release of the Sloan Digital Sky Survey: First Spectroscopic Data from the SDSS-III Baryon Oscillation Spectroscopic Survey

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ahn, Christopher P.; Alexandroff, Rachael; Allende Prieto, Carlos

2012-11-19

The Sloan Digital Sky Survey III (SDSS-III) presents the first spectroscopic data from the Baryon Oscillation Spectroscopic Survey (BOSS). This ninth data release (DR9) of the SDSS project includes 535,995 new galaxy spectra (median z=0.52), 102,100 new quasar spectra (median z=2.32), and 90,897 new stellar spectra, along with the data presented in previous data releases. These spectra were obtained with the new BOSS spectrograph and were taken between 2009 December and 2011 July. In addition, the stellar parameters pipeline, which determines radial velocities, surface temperatures, surface gravities, and metallicities of stars, has been updated and refined with improvements in temperaturemore » estimates for stars with T_eff<5000 K and in metallicity estimates for stars with [Fe/H]>-0.5. DR9 includes new stellar parameters for all stars presented in DR8, including stars from SDSS-I and II, as well as those observed as part of the SDSS-III Sloan Extension for Galactic Understanding and Exploration-2 (SEGUE-2). The astrometry error introduced in the DR8 imaging catalogs has been corrected in the DR9 data products. The next data release for SDSS-III will be in Summer 2013, which will present the first data from the Apache Point Observatory Galactic Evolution Experiment (APOGEE) along with another year of data from BOSS, followed by the final SDSS-III data release in December 2014.« less

Fluorescence Spectroscopic Properties of Normal and Abnormal Biomedical Materials

NASA Astrophysics Data System (ADS)

Pradhan, Asima

Steady state and time-resolved optical spectroscopy and native fluorescence is used to study the physical and optical properties occurring in diseased and non-diseased biological human tissue, in particular, cancer of the human breast, artery and the dynamics of a photosensitizer useful in photodynamic therapy. The main focus of the research is on the optical properties of cancer and atherosclerotic tissues as compared to their normal counterparts using the different luminescence based spectroscopic techniques such as steady state fluorescence, time-resolved fluorescence, excitation spectroscopy and phosphorescence. The excitation and steady-state spectroscopic fluorescence using visible excitation wavelength displays a difference between normal and malignant tissues. This difference is attributed to absorption of the emission by hemoglobin in normal tissues. This method using 488nm fails to distinguish neoplastic tissue such as benign tissues and tumors from malignant tumors. The time-resolved fluorescence at visible, near -uv and uv excitation wavelengths display non-exponential profiles which are significantly different for malignant tumors as compared to non-malignant tissues only with uv excitation. The differences observed with visible and near-uv excitation wavelengths are not as significant. The non-exponential profiles are interpreted as due to a combination of fluorophores along with the action of non-radiative processes. Low temperature luminescence studies confirm the occurrence of non-radiative decay processes while temporal studies of various relevant biomolecules indicate the probable fluorophores responsible for the observed signal in tissues. Phosphorescence from human tissues have been observed for the first time and lifetimes of a few hundred nanoseconds are measured for malignant and benign tissues. Time-resolved fluorescence studies of normal artery and atherosclerotic plaque have shown that a combination of two excitation wavelengths can

A CATALOG OF NEW SPECTROSCOPICALLY CONFIRMED MASSIVE OB STARS IN CARINA

DOE Office of Scientific and Technical Information (OSTI.GOV)

Alexander, Michael J.; Hanes, Richard J.; McSwain, M. Virginia

2016-12-01

The Carina star-forming region is one of the largest in the Galaxy, and its massive star population is still being unveiled. The large number of stars combined with high, and highly variable, interstellar extinction makes it inherently difficult to find OB stars in this type of young region. We present the results of a spectroscopic campaign to study the massive star population of the Carina Nebula, with the primary goal to confirm or reject previously identified Carina OB star candidates. A total of 141 known O- and B-type stars and 94 candidates were observed, of which 73 candidates had highmore » enough signal-to-noise ratio to classify. We find 23 new OB stars within the Carina Nebula, a 32% confirmation rate. One of the new OB stars has blended spectra and is suspected to be a double-lined spectroscopic binary (SB2). We also reclassify the spectral types of the known OB stars and discover nine new SB2s among this population. Finally, we discuss the spatial distribution of these new OB stars relative to known structures in the Carina Nebula.« less

Thirty New Low-mass Spectroscopic Binaries

NASA Astrophysics Data System (ADS)

Shkolnik, Evgenya L.; Hebb, Leslie; Liu, Michael C.; Reid, I. Neill; Collier Cameron, Andrew

2010-06-01

As part of our search for young M dwarfs within 25 pc, we acquired high-resolution spectra of 185 low-mass stars compiled by the NStars project that have strong X-ray emission. By cross-correlating these spectra with radial velocity standard stars, we are sensitive to finding multi-lined spectroscopic binaries. We find a low-mass spectroscopic binary fraction of 16% consisting of 27 SB2s, 2 SB3s, and 1 SB4, increasing the number of known low-mass spectroscopic binaries (SBs) by 50% and proving that strong X-ray emission is an extremely efficient way to find M-dwarf SBs. WASP photometry of 23 of these systems revealed two low-mass eclipsing binaries (EBs), bringing the count of known M-dwarf EBs to 15. BD-22 5866, the ESB4, was fully described in 2008 by Shkolnik et al. and CCDM J04404+3127 B consists of two mid-M stars orbiting each other every 2.048 days. WASP also provided rotation periods for 12 systems, and in the cases where the synchronization time scales are short, we used P rot to determine the true orbital parameters. For those with no P rot, we used differential radial velocities to set upper limits on orbital periods and semimajor axes. More than half of our sample has near-equal-mass components (q > 0.8). This is expected since our sample is biased toward tight orbits where saturated X-ray emission is due to tidal spin-up rather than stellar youth. Increasing the samples of M-dwarf SBs and EBs is extremely valuable in setting constraints on current theories of stellar multiplicity and evolution scenarios for low-mass multiple systems. Based on observations collected at the W. M. Keck Observatory, the Canada-France-Hawaii Telescope and by the WASP Consortium. The Keck Observatory is operated as a scientific partnership between the California Institute of Technology, the University of California, and NASA, and was made possible by the generous financial support of the W. M. Keck Foundation. The CFHT is operated by the National Research Council of Canada

MULTI-SITE EVALUATIONS OF CANDIDATE METHODOLOGIES FOR DETERMINING COARSE PARTICULATE (PM 10-2.5) CONCENTRATIONS: AUGUST 2005 UPDATED REPORT REGARDING SECOND-GENERATION AND NEW PM 10-2.5 SAMPLERS

EPA Science Inventory

Multi-site field studies were conducted to evaluate the performance of sampling methods for measuring the coarse fraction of PM10 (PM10 2.5) in ambient air. The field studies involved the use of both time-integrated filter-based and direct continuous methods. Despite operationa...

Physics of the inner heliosphere: Mechanisms, models and observational signatures

NASA Technical Reports Server (NTRS)

Withbroe, G. L.

1985-01-01

The physics of the solar wind acceleration phenomena (e.g. effect of transient momentum deposition on the temporal and spatial variation of the temperature, density and flow speed of the solar wind, formation of shocks, etc.) and the resultant effects on observational signatures, particularly spectroscopic signature are studied. Phenomena under study include: (1) wave motions, particularly spectroscopic signatures are studied. Phenomena under study include:(1) wave motions, particularly Alfven and fast mode waves, (2) the formation of standing shocks in the inner heliosphere as a result of momentum and/or heat addition to the wind and (3) coronal transient phenomena where momentum and/or heat are deposited in the corona to produce transient plasma heating and/or mass ejections. Also included are the theoretical investigation of spectroscopic plasma diagnostics for the inner heliosphere and the analysis of existing Skylab and other relevant data.

A Spectroscopic and Photometric Study of Gravitational Microlensing Events

NASA Astrophysics Data System (ADS)

Kane, Stephen R.

2000-08-01

Gravitational microlensing has generated a great deal of scientific interest over recent years. This has been largely due to the realization of its wide-reaching applications, such as the search for dark matter, the detection of planets, and the study of Galactic structure. A significant observational advance has been that most microlensing events can be identified in real-time while the source is still being lensed. More than 400 microlensing events have now been detected towards the Galactic bulge and Magellanic Clouds by the microlensing survey teams EROS, MACHO, OGLE, DUO, and MOA. The real-time detection of these events allows detailed follow-up observations with much denser sampling, both photometrically and spectroscopically. The research undertaken in this project on photometric studies of gravitational microlensing events has been performed as a member of the PLANET (Probing Lensing Anomalies NETwork) collaboration. This is a worldwide collaboration formed in the early part of 1995 to study microlensing anomalies - departures from an achromatic point source, point lens light curve - through rapidly-sampled, multi-band, photometry. PLANET has demonstrated that it can achieve 1% photometry under ideal circumstances, making PLANET observations sensitive to detection of Earth-mass planets which require characterization of 1%--2% deviations from a standard microlensing light curve. The photometric work in this project involved over 5 months using the 1.0 m telescope at Canopus Observatory in Australia, and 3 separate observing runs using the 0.9 m telescope at the Cerro Tololo Inter-American Observatory (CTIO) in Chile. Methods were developed to reduce the vast amount of photometric data using the image analysis software MIDAS and the photometry package DoPHOT. Modelling routines were then written to analyse a selection of the resulting light curves in order to detect any deviation from an achromatic point source - point lens light curve. The photometric

Velocity segregation and systematic biases in velocity dispersion estimates with the SPT-GMOS spectroscopic survey

DOE PAGES

Bayliss, Matthew. B.; Zengo, Kyle; Ruel, Jonathan; ...

2017-03-07

The velocity distribution of galaxies in clusters is not universal; rather, galaxies are segregated according to their spectral type and relative luminosity. We examine the velocity distributions of different populations of galaxies within 89 Sunyaev Zel'dovich (SZ) selected galaxy clusters spanningmore » $ 0.28 < z < 1.08$. Our sample is primarily draw from the SPT-GMOS spectroscopic survey, supplemented by additional published spectroscopy, resulting in a final spectroscopic sample of 4148 galaxy spectra---2868 cluster members. The velocity dispersion of star-forming cluster galaxies is $$17\\pm4$$% greater than that of passive cluster galaxies, and the velocity dispersion of bright ($$m < m^{*}-0.5$$) cluster galaxies is $$11\\pm4$$% lower than the velocity dispersion of our total member population. We find good agreement with simulations regarding the shape of the relationship between the measured velocity dispersion and the fraction of passive vs. star-forming galaxies used to measure it, but we find a small offset between this relationship as measured in data and simulations in which suggests that our dispersions are systematically low by as much as 3\\% relative to simulations. We argue that this offset could be interpreted as a measurement of the effective velocity bias that describes the ratio of our observed velocity dispersions and the intrinsic velocity dispersion of dark matter particles in a published simulation result. Here, by measuring velocity bias in this way suggests that large spectroscopic surveys can improve dispersion-based mass-observable scaling relations for cosmology even in the face of velocity biases, by quantifying and ultimately calibrating them out.« less

Velocity segregation and systematic biases in velocity dispersion estimates with the SPT-GMOS spectroscopic survey

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bayliss, Matthew. B.; Zengo, Kyle; Ruel, Jonathan

The velocity distribution of galaxies in clusters is not universal; rather, galaxies are segregated according to their spectral type and relative luminosity. We examine the velocity distributions of different populations of galaxies within 89 Sunyaev Zel'dovich (SZ) selected galaxy clusters spanningmore » $ 0.28 < z < 1.08$. Our sample is primarily draw from the SPT-GMOS spectroscopic survey, supplemented by additional published spectroscopy, resulting in a final spectroscopic sample of 4148 galaxy spectra---2868 cluster members. The velocity dispersion of star-forming cluster galaxies is $$17\\pm4$$% greater than that of passive cluster galaxies, and the velocity dispersion of bright ($$m < m^{*}-0.5$$) cluster galaxies is $$11\\pm4$$% lower than the velocity dispersion of our total member population. We find good agreement with simulations regarding the shape of the relationship between the measured velocity dispersion and the fraction of passive vs. star-forming galaxies used to measure it, but we find a small offset between this relationship as measured in data and simulations in which suggests that our dispersions are systematically low by as much as 3\\% relative to simulations. We argue that this offset could be interpreted as a measurement of the effective velocity bias that describes the ratio of our observed velocity dispersions and the intrinsic velocity dispersion of dark matter particles in a published simulation result. Here, by measuring velocity bias in this way suggests that large spectroscopic surveys can improve dispersion-based mass-observable scaling relations for cosmology even in the face of velocity biases, by quantifying and ultimately calibrating them out.« less

Coordination and management of multicenter clinical studies in trauma: Experience from the PRospective Observational Multicenter Major Trauma Transfusion (PROMMTT) Study.

PubMed

Rahbar, Mohammad H; Fox, Erin E; del Junco, Deborah J; Cotton, Bryan A; Podbielski, Jeanette M; Matijevic, Nena; Cohen, Mitchell J; Schreiber, Martin A; Zhang, Jiajie; Mirhaji, Parsa; Duran, Sarah J; Reynolds, Robert J; Benjamin-Garner, Ruby; Holcomb, John B

2012-04-01

Early death due to hemorrhage is a major consequence of traumatic injury. Transfusion practices differ among hospitals and it is unknown which transfusion practices improve survival. This report describes the experience of the PRospective Observational Multicenter Major Trauma Transfusion (PROMMTT) Study Data Coordination Center in designing and coordinating a study to examine transfusion practices at ten Level 1 trauma centers in the US. PROMMTT was a multisite prospective observational study of severely injured transfused trauma patients. The clinical sites collected real-time information on the timing and amounts of blood product infusions as well as colloids and crystalloids, vital signs, initial diagnostic and clinical laboratory tests, life saving interventions and other clinical care data. Between July 2009 and October 2010, PROMMTT screened 12,561 trauma admissions and enrolled 1245 patients who received one or more blood transfusions within 6h of Emergency Department (ED) admission. A total of 297 massive transfusions were observed over the course of the study at a combined rate of 5.0 massive transfusion patients/week. PROMMTT is the first multisite study to collect real-time prospective data on trauma patients requiring transfusion. Support from the Department of Defense and collaborative expertise from the ten participating centers helped to demonstrate the feasibility of prospective trauma transfusion studies. The observational data collected from this study will be an invaluable resource for research in trauma surgery and it will guide the design and conduct of future randomized trials. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

Spectroscopic and solubility characteristics of oxidized soots

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chughtai, A.R.; Jassim, J.A.; Peterson, J.H.

1991-01-01

Spectroscopic and solubility studies of reaction products of soot (black carbon) with O{sub 3}, NO{sub 2}/N{sub 2}O{sub 4}, and SO{sub 2} have revealed a relationship between reactivity and product solubility and structure. A remarkably high solubility of ozonated n-hexane soot has its origin in the formation of anhydride and lactone surface structures and their subsequent hydrolysis to carboxylic acid species. Calculations indicate that the rate of surface carboxylation of 0.1-{mu}m diameter spheroidal soot particles, in the presence of 50 ppbv ozone at ambient temperature, is such that solubilization may occur within a 30-minute time frame. Measurements on ambient air aerosolmore » samples in metropolitan Denver are consistent with these observations and demonstrate the high reactivity of soot with ozone even at very low levels in natural systems.« less

Accurate structural and spectroscopic characterization of prebiotic molecules: The neutral and cationic acetyl cyanide and their related species.

PubMed

Bellili, A; Linguerri, R; Hochlaf, M; Puzzarini, C

2015-11-14

In an effort to provide an accurate structural and spectroscopic characterization of acetyl cyanide, its two enolic isomers and the corresponding cationic species, state-of-the-art computational methods, and approaches have been employed. The coupled-cluster theory including single and double excitations together with a perturbative treatment of triples has been used as starting point in composite schemes accounting for extrapolation to the complete basis-set limit as well as core-valence correlation effects to determine highly accurate molecular structures, fundamental vibrational frequencies, and rotational parameters. The available experimental data for acetyl cyanide allowed us to assess the reliability of our computations: structural, energetic, and spectroscopic properties have been obtained with an overall accuracy of about, or better than, 0.001 Å, 2 kcal/mol, 1-10 MHz, and 11 cm(-1) for bond distances, adiabatic ionization potentials, rotational constants, and fundamental vibrational frequencies, respectively. We are therefore confident that the highly accurate spectroscopic data provided herein can be useful for guiding future experimental investigations and/or astronomical observations.

Probability distributions of molecular observables computed from Markov models. II. Uncertainties in observables and their time-evolution

NASA Astrophysics Data System (ADS)

Chodera, John D.; Noé, Frank

2010-09-01

Discrete-state Markov (or master equation) models provide a useful simplified representation for characterizing the long-time statistical evolution of biomolecules in a manner that allows direct comparison with experiments as well as the elucidation of mechanistic pathways for an inherently stochastic process. A vital part of meaningful comparison with experiment is the characterization of the statistical uncertainty in the predicted experimental measurement, which may take the form of an equilibrium measurement of some spectroscopic signal, the time-evolution of this signal following a perturbation, or the observation of some statistic (such as the correlation function) of the equilibrium dynamics of a single molecule. Without meaningful error bars (which arise from both approximation and statistical error), there is no way to determine whether the deviations between model and experiment are statistically meaningful. Previous work has demonstrated that a Bayesian method that enforces microscopic reversibility can be used to characterize the statistical component of correlated uncertainties in state-to-state transition probabilities (and functions thereof) for a model inferred from molecular simulation data. Here, we extend this approach to include the uncertainty in observables that are functions of molecular conformation (such as surrogate spectroscopic signals) characterizing each state, permitting the full statistical uncertainty in computed spectroscopic experiments to be assessed. We test the approach in a simple model system to demonstrate that the computed uncertainties provide a useful indicator of statistical variation, and then apply it to the computation of the fluorescence autocorrelation function measured for a dye-labeled peptide previously studied by both experiment and simulation.