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Sample records for n-dimensional intrinsically universal

  1. Intrinsic Changes: Energy Saving Behaviour among Resident University Students

    ERIC Educational Resources Information Center

    Black, Rosemary; Davidson, Penny; Retra, Karen

    2010-01-01

    This paper presents the results of a study that explored the effectiveness of three intervention strategies in facilitating energy saving behaviour among resident undergraduate university students. In contrast to a dominant practice of motivating with rewards or competition this study sought to appeal to students' intrinsic motivations. An…

  2. Intrinsic Periodicity of Time and Nonmaximal Entropy of Universe

    NASA Astrophysics Data System (ADS)

    Nielsen, Holger B.; Ninomiya, Masao

    The universe is certainly not yet in a total thermodynamical equilibrium. Thus some law of special initial conditions is needed. A universe or a system imposed to behave periodically will then require "initial conditions." Those initial conditions will not look like the type we already have, which have been suffered the heat death. In other words, the required initial conditions should not have been obtained the maximal entropy — like a random state. The intrinsic periodicity successfully explains why entropy is not maximal but it fails, phenomenologically, in leading to a constant entropy.

  3. The relationship between motivational structure, sense of control, intrinsic motivation and university students' alcohol consumption.

    PubMed

    Shamloo, Zohreh Sepehri; Cox, W Miles

    2010-02-01

    The aim of this study was to determine how sense of control and intrinsic motivation are related to university students' motivational structure and alcohol consumption. Participants were 94 university students who completed the Personal Concerns Inventory, Shapiro Control Inventory, Helplessness Questionnaire, Intrinsic-Extrinsic Aspirations Scale, and Alcohol Use Questionnaire. Results showed that sense of control and intrinsic motivation were positively correlated with adaptive motivation and negatively correlated with alcohol consumption. Mediational analyses indicated that adaptive motivation fully mediated the relationship between sense of control/intrinsic motivation and alcohol consumption.

  4. Large-scale analysis of intrinsic disorder flavors and associated functions in the protein sequence universe.

    PubMed

    Necci, Marco; Piovesan, Damiano; Tosatto, Silvio C E

    2016-12-01

    Intrinsic disorder (ID) in proteins has been extensively described for the last decade; a large-scale classification of ID in proteins is mostly missing. Here, we provide an extensive analysis of ID in the protein universe on the UniProt database derived from sequence-based predictions in MobiDB. Almost half the sequences contain an ID region of at least five residues. About 9% of proteins have a long ID region of over 20 residues which are more abundant in Eukaryotic organisms and most frequently cover less than 20% of the sequence. A small subset of about 67,000 (out of over 80 million) proteins is fully disordered and mostly found in Viruses. Most proteins have only one ID, with short ID evenly distributed along the sequence and long ID overrepresented in the center. The charged residue composition of Das and Pappu was used to classify ID proteins by structural propensities and corresponding functional enrichment. Swollen Coils seem to be used mainly as structural components and in biosynthesis in both Prokaryotes and Eukaryotes. In Bacteria, they are confined in the nucleoid and in Viruses provide DNA binding function. Coils & Hairpins seem to be specialized in ribosome binding and methylation activities. Globules & Tadpoles bind antigens in Eukaryotes but are involved in killing other organisms and cytolysis in Bacteria. The Undefined class is used by Bacteria to bind toxic substances and mediate transport and movement between and within organisms in Viruses. Fully disordered proteins behave similarly, but are enriched for glycine residues and extracellular structures.

  5. Testing cosmology from fundamental considerations: Is the Friedmann universe intrinsically flat

    NASA Astrophysics Data System (ADS)

    Mitra, Abhas

    2014-02-01

    Recently Melia and Shevchuk (Mon Not R Astron Soc 419:2579,2012) (MS) have proposed the so-called cosmology where the "Gravitational Horizon" of the universe is equal to the distance travelled by light since "Big Bang". Here we would like to see whether the basic claim is correct or not because MS have not given any cogent derivation for the same. Essentially we will compare the twin expressions for the Einstein energy momentum complex (EMC) of the Friedmann universe obtained by using an appropriate superpotential and also by a direct method. To enable a meaningful comparison of the twin expressions, both are computed by using the same quasi-Cartesian coordinates. We however do not claim that Einstein EMC is superior to many other routes of defining EM of a self-gravitating system. In fact, for static isolated spherical syatems, the idea of a coordinate independent field energy of Lynden-Bell and Katz (Mon Not R Astron Soc 213:21, 1985) might be quite physically significant. Yet, here, we use Einstein EMC because (i) our system is non-static and not isolated one (ii) our primary aim is not find any absolute value of EM, and, finally, (iii) only Einstein pseudo-tensor offers equivalent twin expressions for EM which one can be equated irrespective of any physical significance. Following such comparison of equivalent twin expressions of Einstein energy, we find an exact proof as to why Friedmann universe must be spatially flat even though, mathematically one can conceive of curved spaces in any dimension. Additionally, it follows that, apparently, the scale factor as insisted by proposition. Nonetheless, because of close similarity of this form, , with the (vacuum) Milne metric, and also because of implied unphysical equation of state, cosmology is unlikely to represent the physical universe.

  6. Emotional Creativity as Predictor of Intrinsic Motivation and Academic Engagement in University Students: The Mediating Role of Positive Emotions

    PubMed Central

    Oriol, Xavier; Amutio, Alberto; Mendoza, Michelle; Da Costa, Silvia; Miranda, Rafael

    2016-01-01

    Objective: Emotional creativity (EC) implies experiencing a complex emotional life, which is becoming increasingly necessary in societies that demand innovation and constant changes. This research studies the relation of EC as a dispositional trait with intrinsic motivation (IM) and academic engagement (AE). Methods: A sample of 428 university Chilean students, 36.5% men and 63.5% women, with ages from 18 to 45 years-old (M = 20.37; DT = 2.71). Additionally, the mediating function of class-related positive emotions in this relation is explored. Results: The obtained data indicate that developing high levels of dispositional EC enhances the activation of positive emotions, such as gratitude, love and hope, in the classroom. Furthermore, EC predicts IM and AE of university students by the experience of positive emotions. Conclusion: These results compel us to be aware of the importance that university students can understand the complexity of the emotional processes they undergo. A greater control of these emotions would allow students to maintain higher levels of interest in their studies at the different educational stages and to avoid the risk of school failure. PMID:27610091

  7. Some properties of n-dimensional triangulations

    NASA Technical Reports Server (NTRS)

    Lawson, C. L.

    1985-01-01

    A number of mathematical results relevant to the problem of constructing a triangulation, i.e., a simplicial tessellation, of the convex hull of an arbitrary finite set of points in n-space are described. The principal results achieved are: (1) a set of n+2 points in n-space may be triangulated in at most 2 different ways; (2) the sphere test defined in this report selects a preferred one of these two triangulations; (3) a set of parameters is defined that permits the characterization and enumeration of all sets of n+2 points in n-space that are significantly different from the point of view of their possible triangulation; (4) the local sphere test induces a global sphere test property for a triangulation; and (5) a triangulation satisfying the global sphere property is dual to the n-dimensional Dirichlet tesselation, i.e., it is a Delaunay triangulation.

  8. NDF: Extensible N-dimensional Data Format Library

    NASA Astrophysics Data System (ADS)

    Warren-Smith, Rodney F.; Berry, David S.; Jenness, Tim; Draper, Peter W.

    2014-11-01

    The Extensible N-Dimensional Data Format (NDF) stores bulk data in the form of N-dimensional arrays of numbers. It is typically used for storing spectra, images and similar datasets with higher dimensionality. The NDF format is based on the Hierarchical Data System (HDS) and is extensible; not only does it provide a comprehensive set of standard ancillary items to describe the data, it can also be extended indefinitely to handle additional user-defined information of any type. The NDF library is used to read and write files in the NDF format. It is distributed with the Starlink software (ascl:1110.012).

  9. Quantum Discord of 2 n -Dimensional Bell-Diagonal States

    NASA Astrophysics Data System (ADS)

    Jafarizadeh, M. A.; Karimi, N.; Amidi, D.; Zahir Olyaei, H.

    2016-03-01

    In this study, using the concept of relative entropy as a distance measure of correlations we investigate the important issue of evaluating quantum correlations such as entanglement, dissonance and classical correlations for 2 n -dimensional Bell-diagonal states. We provide an analytical technique, which describes how we find the closest classical states(CCS) and the closest separable states(CSS) for these states. Then analytical results are obtained for quantum discord of 2 n -dimensional Bell-diagonal states. As illustration, some special cases are examined. Finally, we investigate the additivity relation between the different correlations for the separable generalized Bloch sphere states.

  10. Nondegenerate superintegrable systems in n-dimensional Euclidean spaces

    SciTech Connect

    Kalnins, E. G.; Kress, J. M. Miller, W.; Pogosyan, G. S.

    2007-03-15

    We analyze the concept of a nondegenerate superintegrable system in n-dimensional Euclidean space. Attached to this idea is the notion that every such system affords a separation of variables in one of the various types of generic elliptical coordinates that are possible in complex Euclidean space. An analysis of how these coordinates are arrived at in terms of their expression in terms of Cartesian coordinates is presented in detail. The use of well-defined limiting processes illustrates just how all these systems can be obtained from the most general nondegenerate superintegrable system in n-dimensional Euclidean space. Two examples help with the understanding of how the general results are obtained.

  11. n-dimensional Statistical Inverse Graphical Hydraulic Test Simulator

    SciTech Connect

    2012-09-12

    nSIGHTS (n-dimensional Statistical Inverse Graphical Hydraulic Test Simulator) is a comprehensive well test analysis software package. It provides a user-interface, a well test analysis model and many tools to analyze both field and simulated data. The well test analysis model simulates a single-phase, one-dimensional, radial/non-radial flow regime, with a borehole at the center of the modeled flow system. nSIGHTS solves the radially symmetric n-dimensional forward flow problem using a solver based on a graph-theoretic approach. The results of the forward simulation are pressure, and flow rate, given all the input parameters. The parameter estimation portion of nSIGHTS uses a perturbation-based approach to interpret the best-fit well and reservoir parameters, given an observed dataset of pressure and flow rate.

  12. Methods, apparatuses, and computer-readable media for projectional morphological analysis of N-dimensional signals

    DOEpatents

    Glazoff, Michael V.; Gering, Kevin L.; Garnier, John E.; Rashkeev, Sergey N.; Pyt'ev, Yuri Petrovich

    2016-05-17

    Embodiments discussed herein in the form of methods, systems, and computer-readable media deal with the application of advanced "projectional" morphological algorithms for solving a broad range of problems. In a method of performing projectional morphological analysis, an N-dimensional input signal is supplied. At least one N-dimensional form indicative of at least one feature in the N-dimensional input signal is identified. The N-dimensional input signal is filtered relative to the at least one N-dimensional form and an N-dimensional output signal is generated indicating results of the filtering at least as differences in the N-dimensional input signal relative to the at least one N-dimensional form.

  13. Ambient Metrics for n-Dimensional pp-Waves

    NASA Astrophysics Data System (ADS)

    Leistner, Thomas; Nurowski, Pawel

    2010-06-01

    We provide an explicit formula for the Fefferman-Graham ambient metric of an n-dimensional conformal pp-wave in those cases where it exists. In even dimensions we calculate the obstruction explicitly. Furthermore, we describe all 4-dimensional pp-waves that are Bach-flat, and give a large class of Bach-flat examples which are conformally Cotton-flat, but not conformally Einstein. Finally, as an application, we use the obtained ambient metric to show that even-dimensional pp-waves have vanishing critical Q-curvature.

  14. Intrinsic Geodesy

    DTIC Science & Technology

    1952-03-01

    Variation with the Height of the Principal Radii of Curvature in Somigliana’s Theory"), Bollettino di Geodesia e Scienze Affini, anno VIII, 1950 46...MARUSSI, A., "Principi di Geodesia Intrinseca applicati al campo di Somigliana" ("Principles of Intrinsic Geodesy Applied to Somigliana’s Field...34), Bollettino di Geodesia e Scienze Affini, anno VIII, 1950; and also Atti della XLII Riunione _dela Socie&Ljtsjjganaper il Progresso delle Scienze, Roma

  15. t-topology on the n-dimensional Minkowski space

    SciTech Connect

    Agrawal, Gunjan; Shrivastava, Sampada

    2009-05-15

    In this paper, a topological study of the n-dimensional Minkowski space, n>1, with t-topology, denoted by M{sup t}, has been carried out. This topology, unlike the usual Euclidean one, is more physically appealing being defined by means of the Lorentzian metric. It shares many topological properties with similar candidate topologies and it has the advantage of being first countable. Compact sets of M{sup t} and continuous maps into M{sup t} are studied using the notion of Zeno sequences besides characterizing those sets that have the same subspace topologies induced from the Euclidean and t-topologies on n-dimensional Minkowski space. A necessary and sufficient condition for a compact set in the Euclidean n-space to be compact in M{sup t} is obtained, thereby proving that the n-cube, n>1, as a subspace of M{sup t}, is not compact, while a segment on a timelike line is compact in M{sup t}. This study leads to the nonsimply connectedness of M{sup t}, for n=2. Further, Minkowski space with s-topology has also been dealt with.

  16. N-dimensional hypervolumes to study stability of complex ecosystems

    PubMed Central

    Barros, Ceres; Thuiller, Wilfried; Georges, Damien; Boulangeat, Isabelle; Münkemüller, Tamara

    2016-01-01

    Although our knowledge on the stabilising role of biodiversity and on how it is affected by perturbations has greatly improved, we still lack a comprehensive view on ecosystem stability that is transversal to different habitats and perturbations. Hence, we propose a framework that takes advantage of the multiplicity of components of an ecosystem and their contribution to stability. Ecosystem components can range from species or functional groups, to different functional traits, or even the cover of different habitats in a landscape mosaic. We make use of n-dimensional hypervolumes to define ecosystem states and assess how much they shift after environmental changes have occurred. We demonstrate the value of this framework with a study case on the effects of environmental change on Alpine ecosystems. Our results highlight the importance of a multidimensional approach when studying ecosystem stability and show that our framework is flexible enough to be applied to different types of ecosystem components, which can have important implications for the study of ecosystem stability and transient dynamics. PMID:27282314

  17. N-dimensional hypervolumes to study stability of complex ecosystems.

    PubMed

    Barros, Ceres; Thuiller, Wilfried; Georges, Damien; Boulangeat, Isabelle; Münkemüller, Tamara

    2016-07-01

    Although our knowledge on the stabilising role of biodiversity and on how it is affected by perturbations has greatly improved, we still lack a comprehensive view on ecosystem stability that is transversal to different habitats and perturbations. Hence, we propose a framework that takes advantage of the multiplicity of components of an ecosystem and their contribution to stability. Ecosystem components can range from species or functional groups, to different functional traits, or even the cover of different habitats in a landscape mosaic. We make use of n-dimensional hypervolumes to define ecosystem states and assess how much they shift after environmental changes have occurred. We demonstrate the value of this framework with a study case on the effects of environmental change on Alpine ecosystems. Our results highlight the importance of a multidimensional approach when studying ecosystem stability and show that our framework is flexible enough to be applied to different types of ecosystem components, which can have important implications for the study of ecosystem stability and transient dynamics.

  18. Intrinsic Motivation in Physical Education

    ERIC Educational Resources Information Center

    Davies, Benjamin; Nambiar, Nathan; Hemphill, Caroline; Devietti, Elizabeth; Massengale, Alexandra; McCredie, Patrick

    2015-01-01

    This article describes ways in which educators can use Harter's perceived competence motivation theory, the achievement goal theory, and self-determination theory to develop students' intrinsic motivation to maintain physical fitness, as demonstrated by the Sound Body Sound Mind curriculum and proven effective by the 2013 University of…

  19. Critical probability of percolation over bounded region in N-dimensional Euclidean space

    NASA Astrophysics Data System (ADS)

    Roubin, Emmanuel; Colliat, Jean-Baptiste

    2016-03-01

    Following Tomita and Murakami (Research of Pattern Formation ed R Takaki (Tokyo: KTK Scientific Publishers) pp 197-203) we propose an analytical model to predict the critical probability of percolation. It is based on the excursion set theory which allows us to consider N-dimensional bounded regions. Details are given for the three-dimensional (3D) case and statistically representative volume elements are calculated. Finally, generalisation to the N-dimensional case is made.

  20. What Does it Mean to be a Christian? Exploring the Religious Identity of Intrinsically and Extrinsically Religious Black Seventh-Day Adventist University Students

    ERIC Educational Resources Information Center

    Ramirez, Octavio; Ashley, George; Cort, Malcolm

    2014-01-01

    This study explored the religious identity of Black Seventh-day Adventist University students and the elements that helped form their religious identity. The unidirectional, bidirectional and channeling models of socialization was used to describe the formation of religious identity. The data were collected in two stages. At the first stage, a…

  1. N-dimensional alternate coined quantum walks from a dispersion-relation perspective

    NASA Astrophysics Data System (ADS)

    Roldán, Eugenio; Di Franco, Carlo; Silva, Fernando; de Valcárcel, Germán J.

    2013-02-01

    We suggest an alternative definition of N-dimensional coined quantum walk by generalizing a recent proposal [Di Franco , Phys. Rev. Lett.0031-9007PRLTAO10.1103/PhysRevLett.106.080502 106, 080502 (2011)]. This N-dimensional alternate quantum walk, AQW(N), in contrast with the standard definition of the N-dimensional quantum walk, QW(N), requires only a coin qubit. We discuss the quantum diffusion properties of AQW(2) and AQW(3) by analyzing their dispersion relations that reveal, in particular, the existence of diabolical points. This allows us to highlight interesting similarities with other well-known physical phenomena. We also demonstrate that AQW(3) generates considerable genuine multipartite entanglement. Finally, we discuss the implementability of AQW(N).

  2. Blowup phenomena for the \\varvec{N}-dimensional compressible Euler equations with damping

    NASA Astrophysics Data System (ADS)

    Cheung, Ka Luen

    2017-02-01

    In this paper, we extend the finite propagation speed property for the compressible Euler equations with damping from the three-dimensional case to the general N-dimensional case. Subsequently, blowup results of the N-dimensional compressible Euler equations with damping are obtained. More precisely, we show that if the initial data int limits _0^∞f(r)V(0,r) {d}r are sufficiently large, then blowup phenomena occurs and the finite blowup time can be estimated, where f is a general test function with mild conditions and V represents the speed of the fluid in radial symmetry.

  3. Intrinsic Nilpotent Approximation.

    DTIC Science & Technology

    1985-06-01

    RD-A1II58 265 INTRINSIC NILPOTENT APPROXIMATION(U) MASSACHUSETTS INST 1/2 OF TECH CAMBRIDGE LAB FOR INFORMATION AND, DECISION UMCLRSSI SYSTEMS C...TYPE OF REPORT & PERIOD COVERED Intrinsic Nilpotent Approximation Technical Report 6. PERFORMING ORG. REPORT NUMBER LIDS-R-1482 7. AUTHOR(.) S...certain infinite-dimensional filtered Lie algebras L by (finite-dimensional) graded nilpotent Lie algebras or g . where x E M, (x,,Z) E T*M/O. It

  4. INTRINSIC BISPECTRA OF COSMIC MAGNETIC FIELDS

    SciTech Connect

    Brown, Iain A.

    2011-06-01

    Forthcoming data sets from the Planck experiment and others are in a position to probe the cosmic microwave background (CMB) non-Gaussianity with higher accuracy than has yet been possible, and potentially open a new window into the physics of the very early universe. However, a signal need not necessarily be inflationary in origin, and possible contaminants should be examined in detail. One such is provided by early universe magnetic fields, which can be produced by a variety of models including during an inflationary phase, at phase transitions, or seeded by cosmic defects. Should such fields have been extant in the early universe, they would provide a natural source of CMB non-Gaussianity. Knowledge of the CMB angular bispectrum requires the complete Fourier-space (or 'intrinsic') bispectrum. In this paper, I consider in detail the intrinsic bispectra of an early-universe magnetic field for a range of power-law magnetic spectra.

  5. Quantum geometrodynamics with intrinsic time development

    NASA Astrophysics Data System (ADS)

    Soo, Chopin

    2016-07-01

    Quantum geometrodynamics with intrinsic time development is presented. Paradigm shift from full spacetime covariance to spatial diffeomorphism invariance yields a nonvanishing Hamiltonian, a resolution of the ‘problem of time’ and gauge-invariant temporal ordering in an ever expanding universe. Einstein’s general relativity is a particular realization of a wider class of theories; and the framework prompts natural extensions and improvements with the consequent dominance of Cotton-York potential at early times when the universe was small.

  6. Intrinsic Patterns of Human Activity

    NASA Astrophysics Data System (ADS)

    Hu, Kun; Ivanov, Plamen Ch.; Chen, Zhi; Hilton, Michael; Stanley, H. Eugene; Shea, Steven

    2003-03-01

    Activity is one of the defining features of life. Control of human activity is complex, being influenced by many factors both extrinsic and intrinsic to the body. The most obvious extrinsic factors that affect activity are the daily schedule of planned events, such as work and recreation, as well as reactions to unforeseen or random events. These extrinsic factors may account for the apparently random fluctuations in human motion observed over short time scales. The most obvious intrinsic factors are the body clocks including the circadian pacemaker that influences our sleep/wake cycle and ultradian oscillators with shorter time scales [2, 3]. These intrinsic rhythms may account for the underlying regularity in average activity level over longer periods of up to 24 h. Here we ask if the known extrinsic and intrinsic factors fully account for all complex features observed in recordings of human activity. To this end, we measure activity over two weeks from forearm motion in subjects undergoing their regular daily routine. Utilizing concepts from statistical physics, we demonstrate that during wakefulness human activity possesses previously unrecognized complex dynamic patterns. These patterns of activity are characterized by robust fractal and nonlinear dynamics including a universal probability distribution and long-range power-law correlations that are stable over a wide range of time scales (from minutes to hours). Surprisingly, we find that these dynamic patterns are unaffected by changes in the average activity level that occur within individual subjects throughout the day and on different days of the week, and between subjects. Moreover, we find that these patterns persist when the same subjects undergo time-isolation laboratory experiments designed to account for the phase of the circadian pacemaker, and control the known extrinsic factors by restricting behaviors and manipulating scheduled events including the sleep/wake cycle. We attribute these newly

  7. Palatalization and Intrinsic Prosodic Vowel Features in Russian

    ERIC Educational Resources Information Center

    Ordin, Mikhail

    2011-01-01

    The presented study is aimed at investigating the interaction of palatalization and intrinsic prosodic features of the vowel in CVC (consonant+vowel+consonant) syllables in Russian. The universal nature of intrinsic prosodic vowel features was confirmed with the data from the Russian language. It was found that palatalization of the consonants…

  8. Possibilities of identifying cyber attack in noisy space of n-dimensional abstract system

    NASA Astrophysics Data System (ADS)

    Jašek, Roman; Dvořák, Jiří; Janková, Martina; Sedláček, Michal

    2016-06-01

    This article briefly mentions some selected options of current concept for identifying cyber attacks from the perspective of the new cyberspace of real system. In the cyberspace, there is defined n-dimensional abstract system containing elements of the spatial arrangement of partial system elements such as micro-environment of cyber systems surrounded by other suitably arranged corresponding noise space. This space is also gradually supplemented by a new image of dynamic processes in a discreet environment, and corresponding again to n-dimensional expression of time space defining existence and also the prediction for expected cyber attacksin the noise space. Noises are seen here as useful and necessary for modern information and communication technologies (e.g. in processes of applied cryptography in ICT) and then the so-called useless noises designed for initial (necessary) filtering of this highly aggressive environment and in future expectedly offensive background in cyber war (e.g. the destruction of unmanned means of an electromagnetic pulse, or for destruction of new safety barriers created on principles of electrostatic field or on other principles of modern physics, etc.). The key to these new options is the expression of abstract systems based on the models of microelements of cyber systems and their hierarchical concept in structure of n-dimensional system in given cyberspace. The aim of this article is to highlight the possible systemic expression of cyberspace of abstract system and possible identification in time-spatial expression of real environment (on microelements of cyber systems and their surroundings with noise characteristics and time dimension in dynamic of microelements' own time and externaltime defined by real environment). The article was based on a partial task of faculty specific research.

  9. Predicting Intrinsic Motivation

    ERIC Educational Resources Information Center

    Martens, Rob; Kirschner, Paul A.

    2004-01-01

    Intrinsic motivation can be predicted from participants' perceptions of the social environment and the task environment (Ryan & Deci, 2000)in terms of control, relatedness and competence. To determine the degree of independence of these factors 251 students in higher vocational education (physiotherapy and hotel management) indicated the extent to…

  10. [Intrinsic cardiac ganglia].

    PubMed

    Birand, Ahmet

    2008-12-01

    Heart has been considered as the source and the seat of emotions, passion and love. But from the dawn of XIXth century, scientists have emphasized that the heart, though life depends on its ceaseless activity, is merely a electromechanical pump, pumping oxygenated blood. Nowadays, we all know that heart pumps blood commensurate with the needs of the body and this unending toil, and its regulation depends on the intrinsic properties of the myocardium, Frank-Starling Law and neurohumoral contribution. It has been understood, though not clearly enough, that these time-tensions may cause structural or functional cardiac impairments and arrhythmias are related to the autonomic nervous system. Less well known and less taken in account in daily cardiology practice is the fact that heart has an intrinsic cardiac nervous system, or "heart brain" consisting of complex ganglia, intrinsic cardiac ganglia containing afferent (receiving), local circuit (interneurons) and efferent (transmitting) sympathetic and parasympathetic neurons. This review enlightens structural and functional aspects of intrinsic cardiac ganglia as the very first step in the regulation of cardiac function. This issue is important for targets of pharmacological treatment and techniques of cardiac surgery interventions as repair of septal defects, valvular interventions and congenital corrections.

  11. Competition and Intrinsic Motivation.

    ERIC Educational Resources Information Center

    Tripathi, Kailas Nath

    1992-01-01

    Reports on a study of competition, motivation, and performance among 60 adolescents in India. Finds that direct competition with another person led to higher levels of immediate performance. Also finds that indirect competition against a pre-set standard resulted in greater intrinsic motivation. (CFR)

  12. Evaluating Intrinsic Goals.

    ERIC Educational Resources Information Center

    Silberman, Harry F.

    1984-01-01

    A social learning model focusing on intrinsic outcomes of vocational programs is proposed. It would assess technical skills and knowledge, communication skills and literacy, and personal skills and attitudes. Instruments should be devised to measure characteristics of the learning setting, learner involved activities, and nature of consequences of…

  13. Learning from 25 years of the extensible N-Dimensional Data Format

    NASA Astrophysics Data System (ADS)

    Jenness, T.; Berry, D. S.; Currie, M. J.; Draper, P. W.; Economou, F.; Gray, N.; McIlwrath, B.; Shortridge, K.; Taylor, M. B.; Wallace, P. T.; Warren-Smith, R. F.

    2015-09-01

    The extensible N-Dimensional Data Format (NDF) was designed and developed in the late 1980s to provide a data model suitable for use in a variety of astronomy data processing applications supported by the UK Starlink Project. Starlink applications were used extensively, primarily in the UK astronomical community, and form the basis of a number of advanced data reduction pipelines today. This paper provides an overview of the historical drivers for the development of NDF and the lessons learned from using a defined hierarchical data model for many years in data reduction software, data pipelines and in data acquisition systems.

  14. Genetic Algorithm for Optimization: Preprocessing with n Dimensional Bisection and Error Estimation

    NASA Technical Reports Server (NTRS)

    Sen, S. K.; Shaykhian, Gholam Ali

    2006-01-01

    A knowledge of the appropriate values of the parameters of a genetic algorithm (GA) such as the population size, the shrunk search space containing the solution, crossover and mutation probabilities is not available a priori for a general optimization problem. Recommended here is a polynomial-time preprocessing scheme that includes an n-dimensional bisection and that determines the foregoing parameters before deciding upon an appropriate GA for all problems of similar nature and type. Such a preprocessing is not only fast but also enables us to get the global optimal solution and its reasonably narrow error bounds with a high degree of confidence.

  15. Palatalization and intrinsic prosodic vowel features in Russian.

    PubMed

    Ordin, Mikhail

    2011-12-01

    The presented study is aimed at investigating the interaction of palatalization and intrinsic prosodic features of the vowel in CVC (consonant+vowel+consonant) syllables in Russian. The universal nature of intrinsic prosodic vowel features was confirmed with the data from the Russian language. It was found that palatalization of the consonants affects intrinsic fundamental frequency (IFO), intensity (I), and duration of the vowels in CVC syllables by modifying the vowel articulatory parameters such as vowel height and fronting. The obtained results are discussed in the light of opposing theories: those suggesting automatic control and those suggesting active control over intrinsic vowel features.

  16. Misner-Sharp mass in n-dimensional f(R) gravity

    NASA Astrophysics Data System (ADS)

    Zhang, Hongsheng; Hu, Yapeng; Li, Xin-Zhou

    2014-07-01

    We study the Misner-Sharp mass for the f(R) gravity in an n-dimensional (n≥3) spacetime which permits three-type (n-2)-dimensional maximally symmetric subspace. We obtain the Misner-Sharp mass via two approaches. One is the inverse unified first law method and the other is the conserved charge method, which uses a generalized Kodama vector. In the first approach, we assume the unified first law still holds in n-dimensional f(R) gravity, which requires a quasilocal mass form (we define it as the generalized Misner-Sharp mass). In the second approach, the conserved charge corresponding to the generalized local Kodama vector is the generalized Misner-Sharp mass. The two approaches, which are bridged by a constraint, are equivalent. This constraint determines the existence of a well-defined Misner-Sharp mass. In an important special case, we present the explicit form for the static space, and we calculate the Misner-Sharp mass for the Clifton-Barrow solution as an example.

  17. Fractional diffusion equation for an n-dimensional correlated Lévy walk.

    PubMed

    Taylor-King, Jake P; Klages, Rainer; Fedotov, Sergei; Van Gorder, Robert A

    2016-07-01

    Lévy walks define a fundamental concept in random walk theory that allows one to model diffusive spreading faster than Brownian motion. They have many applications across different disciplines. However, so far the derivation of a diffusion equation for an n-dimensional correlated Lévy walk remained elusive. Starting from a fractional Klein-Kramers equation here we use a moment method combined with a Cattaneo approximation to derive a fractional diffusion equation for superdiffusive short-range auto-correlated Lévy walks in the large time limit, and we solve it. Our derivation discloses different dynamical mechanisms leading to correlated Lévy walk diffusion in terms of quantities that can be measured experimentally.

  18. Lattice Boltzmann method for n-dimensional nonlinear hyperbolic conservation laws with the source term.

    PubMed

    Wang, Zhenghua; Shi, Baochang; Xiang, Xiuqiao; Chai, Zhenhua; Lu, Jianhua

    2011-03-01

    It is important for nonlinear hyperbolic conservation laws (NHCL) to own a simulation scheme with high order accuracy, simple computation, and non-oscillatory character. In this paper, a unified and novel lattice Boltzmann model is presented for solving n-dimensional NHCL with the source term. By introducing the high order source term of explicit lattice Boltzmann method (LBM) and the optimum dimensionless relaxation time varied with the specific issues, the effects of space and time resolutions on the accuracy and stability of the model are investigated for the different problems in one to three dimensions. Both the theoretical analysis and numerical simulation validate that the results by the proposed LBM have second-order accuracy in both space and time, which agree well with the analytical solutions.

  19. Intrinsically Disordered Energy Landscapes

    NASA Astrophysics Data System (ADS)

    Chebaro, Yassmine; Ballard, Andrew J.; Chakraborty, Debayan; Wales, David J.

    2015-05-01

    Analysis of an intrinsically disordered protein (IDP) reveals an underlying multifunnel structure for the energy landscape. We suggest that such ‘intrinsically disordered’ landscapes, with a number of very different competing low-energy structures, are likely to characterise IDPs, and provide a useful way to address their properties. In particular, IDPs are present in many cellular protein interaction networks, and several questions arise regarding how they bind to partners. Are conformations resembling the bound structure selected for binding, or does further folding occur on binding the partner in a induced-fit fashion? We focus on the p53 upregulated modulator of apoptosis (PUMA) protein, which adopts an -helical conformation when bound to its partner, and is involved in the activation of apoptosis. Recent experimental evidence shows that folding is not necessary for binding, and supports an induced-fit mechanism. Using a variety of computational approaches we deduce the molecular mechanism behind the instability of the PUMA peptide as a helix in isolation. We find significant barriers between partially folded states and the helix. Our results show that the favoured conformations are molten-globule like, stabilised by charged and hydrophobic contacts, with structures resembling the bound state relatively unpopulated in equilibrium.

  20. Intrinsically Disordered Energy Landscapes

    PubMed Central

    Chebaro, Yassmine; Ballard, Andrew J.; Chakraborty, Debayan; Wales, David J.

    2015-01-01

    Analysis of an intrinsically disordered protein (IDP) reveals an underlying multifunnel structure for the energy landscape. We suggest that such ‘intrinsically disordered’ landscapes, with a number of very different competing low-energy structures, are likely to characterise IDPs, and provide a useful way to address their properties. In particular, IDPs are present in many cellular protein interaction networks, and several questions arise regarding how they bind to partners. Are conformations resembling the bound structure selected for binding, or does further folding occur on binding the partner in a induced-fit fashion? We focus on the p53 upregulated modulator of apoptosis (PUMA) protein, which adopts an -helical conformation when bound to its partner, and is involved in the activation of apoptosis. Recent experimental evidence shows that folding is not necessary for binding, and supports an induced-fit mechanism. Using a variety of computational approaches we deduce the molecular mechanism behind the instability of the PUMA peptide as a helix in isolation. We find significant barriers between partially folded states and the helix. Our results show that the favoured conformations are molten-globule like, stabilised by charged and hydrophobic contacts, with structures resembling the bound state relatively unpopulated in equilibrium. PMID:25999294

  1. Intrinsic Feature Motion Tracking

    SciTech Connect

    Goddard, Jr., James S.

    2013-03-19

    Subject motion during 3D medical scanning can cause blurring and artifacts in the 3D images resulting in either rescans or poor diagnosis. Anesthesia or physical restraints may be used to eliminate motion but are undesirable and can affect results. This software measures the six degree of freedom 3D motion of the subject during the scan under a rigidity assumption using only the intrinsic features present on the subject area being monitored. This movement over time can then be used to correct the scan data removing the blur and artifacts. The software acquires images from external cameras or images stored on disk for processing. The images are from two or three calibrated cameras in a stereo arrangement. Algorithms extract and track the features over time and calculate position and orientation changes relative to an initial position. Output is the 3D position and orientation change measured at each image.

  2. Gaussian Intrinsic Entanglement

    NASA Astrophysics Data System (ADS)

    Mišta, Ladislav; Tatham, Richard

    2016-12-01

    We introduce a cryptographically motivated quantifier of entanglement in bipartite Gaussian systems called Gaussian intrinsic entanglement (GIE). The GIE is defined as the optimized mutual information of a Gaussian distribution of outcomes of measurements on parts of a system, conditioned on the outcomes of a measurement on a purifying subsystem. We show that GIE vanishes only on separable states and exhibits monotonicity under Gaussian local trace-preserving operations and classical communication. In the two-mode case, we compute GIE for all pure states as well as for several important classes of symmetric and asymmetric mixed states. Surprisingly, in all of these cases, GIE is equal to Gaussian Rényi-2 entanglement. As GIE is operationally associated with the secret-key agreement protocol and can be computed for several important classes of states, it offers a compromise between computable and physically meaningful entanglement quantifiers.

  3. Intrinsically variable stars

    NASA Technical Reports Server (NTRS)

    Bohm-Vitense, Erika; Querci, Monique

    1987-01-01

    The characteristics of intrinsically variable stars are examined, reviewing the results of observations obtained with the IUE satellite since its launch in 1978. Selected data on both medium-spectral-class pulsating stars (Delta Cep stars, W Vir stars, and related groups) and late-type variables (M, S, and C giants and supergiants) are presented in spectra, graphs, and tables and described in detail. Topics addressed include the calibration of the the period-luminosity relation, Cepheid distance determination, checking stellar evolution theory by the giant companions of Cepheids, Cepheid masses, the importance of the hydrogen convection zone in Cepheids, temperature and abundance estimates for Population II pulsating stars, mass loss in Population II Cepheids, SWP and LWP images of cold giants and supergiants, temporal variations in the UV lines of cold stars, C-rich cold stars, and cold stars with highly ionized emission lines.

  4. Group-theoretical approach to the construction of bases in 2{sup n}-dimensional Hilbert space

    SciTech Connect

    Garcia, A.; Romero, J. L.; Klimov, A. B.

    2011-06-15

    We propose a systematic procedure to construct all the possible bases with definite factorization structure in 2{sup n}-dimensional Hilbert space and discuss an algorithm for the determination of basis separability. The results are applied for classification of bases for an n-qubit system.

  5. Qutrit teleportation under intrinsic decoherence

    NASA Astrophysics Data System (ADS)

    Jafarpour, Mojtaba; Naderi, Negar

    2016-08-01

    We study qutrit teleportation and its fidelity in the presence and absence of intrinsic decoherence through a qutrit channel. The channel consists of a Heisenberg chain with xyz interaction model and the intrinsic decoherence is implemented through the Milburn model. It is shown that while the fidelity diminishes due to intrinsic decoherence, it may be enhanced if the channel is initially in an entangled state. It is also observed that, for stronger intrinsic decoherence, the initial entanglement of the channel is more effective in enhancing of fidelity.

  6. Spherically symmetric solutions of a (4 + n)-dimensional Einstein Yang Mills model with cosmological constant

    NASA Astrophysics Data System (ADS)

    Brihaye, Yves; Hartmann, Betti

    2005-01-01

    We construct solutions of an Einstein Yang Mills system including a cosmological constant in 4 + n spacetime dimensions, where the n-dimensional manifold associated with the extra dimensions is taken to be Ricci flat. Assuming the matter and metric fields to be independent of the n extra coordinates, a spherical symmetric ansatz for the fields leads to a set of coupled ordinary differential equations. We find that for n > 1 only solutions with either one non-zero Higgs field or with all Higgs fields constant and zero gauge field function (corresponding to a Wu Yang-type ansatz) exist. We give the analytic solutions available in this model. These are 'embedded' Abelian solutions with a diverging size of the manifold associated with the extra n dimensions. Depending on the choice of parameters, these latter solutions either represent naked singularities or they possess a single horizon. We also present solutions of the effective four-dimensional Einstein Yang Mills Higgs-dilaton model, where the higher-dimensional cosmological constant induces a Liouville-type potential. The solutions are non-Abelian solutions with diverging Higgs fields, which exist only up to a maximal value of the cosmological constant.

  7. N-dimensional animal energetic niches clarify behavioural options in a variable marine environment.

    PubMed

    Wilson, Rory P; McMahon, Clive R; Quintana, Flavio; Frere, Esteban; Scolaro, Alejandro; Hays, Graeme C; Bradshaw, Corey J A

    2011-02-15

    Animals respond to environmental variation by exhibiting a number of different behaviours and/or rates of activity, which result in corresponding variation in energy expenditure. Successful animals generally maximize efficiency or rate of energy gain through foraging. Quantification of all features that modulate energy expenditure can theoretically be modelled as an animal energetic niche or power envelope; with total power being represented by the vertical axis and n-dimensional horizontal axes representing extents of processes that affect energy expenditure. Such an energetic niche could be used to assess the energetic consequences of animals adopting particular behaviours under various environmental conditions. This value of this approach was tested by constructing a simple mechanistic energetics model based on data collected from recording devices deployed on 41 free-living Magellanic penguins (Spheniscus magellanicus), foraging from four different colonies in Argentina and consequently catching four different types of prey. Energy expenditure was calculated as a function of total distance swum underwater (horizontal axis 1) and maximum depth reached (horizontal axis 2). The resultant power envelope was invariant, irrespective of colony location, but penguins from the different colonies tended to use different areas of the envelope. The different colony solutions appeared to represent particular behavioural options for exploiting the available prey and demonstrate how penguins respond to environmental circumstance (prey distribution), the energetic consequences that this has for them, and how this affects the balance of energy acquisition through foraging and expenditure strategy.

  8. Family of N-dimensional superintegrable systems and quadratic algebra structures

    NASA Astrophysics Data System (ADS)

    Fazlul Hoque, Md; Marquette, Ian; Zhang, Yao-Zhong

    2016-01-01

    Classical and quantum superintegrable systems have a long history and they possess more integrals of motion than degrees of freedom. They have many attractive properties, wide applications in modern physics and connection to many domains in pure and applied mathematics. We overview two new families of superintegrable Kepler-Coulomb systems with non-central terms and superintegrable Hamiltonians with double singular oscillators of type (n, N — n) in N-dimensional Euclidean space. We present their quadratic and polynomial algebras involving Casimir operators of so(N + 1) Lie algebras that exhibit very interesting decompositions Q(3) ⊕ so(N — 1), Q(3) ⊕ so(n) ⊕ so(N — n) and the cubic Casimir operators. The realization of these algebras in terms of deformed oscillator enables the determination of a finite dimensional unitary representation. We present algebraic derivations of the degenerate energy spectra of these systems and relate them with the physical spectra obtained from the separation of variables.

  9. N-dimensional switch function for energy conservation in multiprocess reaction dynamics.

    PubMed

    Mogo, César; Brandão, João

    2016-06-15

    The MReaDy program was designed for studying Multiprocess Reactive Dynamic systems, that is, complex chemical systems involving different and concurrent reactions. It builds a global potential energy surface integrating a variety of potential energy surfaces, each one of them representing an elementary reaction expected to play a role in the chemical process. For each elementary reaction, energy continuity problems may happen in the transition between potential energy surfaces due to differences in the functional form for each of the fragments, especially if built by different authors. A N-dimensional switch function is introduced in MReaDy in order to overcome such a problem. As an example, results of a collision trajectory calculation for H2  + OH → H3 O are presented, showing smooth transition in the potential energy, leading to conservation in the total energy. Calculations for a hydrogen combustion system from 1000 K up to 4000 K shows a variation of 0.012% when compared to the total energy of the system. © 2016 Wiley Periodicals, Inc.

  10. n-dimensional non uniform rational b-splines for metamodeling

    SciTech Connect

    Turner, Cameron J; Crawford, Richard H

    2008-01-01

    Non Uniform Rational B-splines (NURBs) have unique properties that make them attractive for engineering metamodeling applications. NURBs are known to accurately model many different continuous curve and surface topologies in 1- and 2-variate spaces. However, engineering metamodels of the design space often require hypervariate representations of multidimensional outputs. In essence, design space metamodels are hyperdimensional constructs with a dimensionality determined by their input and output variables. To use NURBs as the basis for a metamodel in a hyperdimensional space, traditional geometric fitting techniques must be adapted to hypervariate and hyperdimensional spaces composed of both continuous and discontinuous variable types. In this paper, they describe the necessary adaptations for the development of a NURBs-based metamodel called a Hyperdimensional Performance Model or HyPerModel. HyPerModels are capable of accurately and reliably modeling nonlinear hyperdimensional objects defined by both continuous and discontinuous variables of a wide variety of topologies, such as those that define typical engineering design spaces. They demonstrate this ability by successfully generating accurate HyPerModels of 10 trial functions laying the foundation for future work with N-dimensional NURBs in design space applications.

  11. N-dimensional non uniform rational B-splines for metamodeling

    SciTech Connect

    Turner, Cameron J; Crawford, Richard H

    2008-01-01

    Non Uniform Rational B-splines (NURBs) have unique properties that make them attractive for engineering metamodeling applications. NURBs are known to accurately model many different continuous curve and surface topologies in 1-and 2-variate spaces. However, engineering metamodels of the design space often require hypervariate representations of multidimensional outputs. In essence, design space metamodels are hyperdimensional constructs with a dimensionality determined by their input and output variables. To use NURBs as the basis for a metamodel in a hyperdimensional space, traditional geometric fitting techniques must be adapted to hypervariate and hyperdimensional spaces composed of both continuous and discontinuous variable types. In this paper, we describe the necessary adaptations for the development of a NURBs-based metamodel called a Hyperdimensional Performance Model or HyPerModel. HyPerModels are capable of accurately and reliably modeling nonlinear hyperdimensional objects defined by both continuous and discontinuous variables of a wide variety of topologies, such as those that define typical engineering design spaces. We demonstrate this ability by successfully generating accurate HyPerModels of 10 trial functions laying the foundation for future work with N-dimensional NURBs in design space applications.

  12. Intrinsic Friction Microscopy

    NASA Astrophysics Data System (ADS)

    Knorr, Daniel; Overney, Rene

    2008-03-01

    A novel scanning probe methodology based on lateral force microscopy is presented wherein kinetic friction measurements, obtained as a function of velocity for various temperatures, are used to deduce apparent Arrhenius-type activation energies for surface and subsurface molecular mobilities. Depending on the coupling strength (cooperativity) between molecular mobilities involved the dissipation energy can carry a significant entropic energy contribution, accounting for the majority of the apparent Arrhenius activation energy. The intrinsic friction methodology also provides a means of directly separating enthalpic energy contributions from entropic ones by employing absolute rate theory. As such, the degree of cooperativity in the system is readily apparent. This methodology is illustrated with nanoscale tribological experiments on two systems, (1) monodisperse, atactic polystyrene and (2) self assembling molecular glassy chromophores. In polystyrene, dissipation was found to be a discrete function of loading, where the γ-relaxation (phenyl group rotation) was recovered for ultra low loads and the β-relaxation (local backbone translation) for higher loads in the same temperature range, indicating sensitivity to surface and subsurface mobilities. For self assembling glassy chromophores, the degree of intermolecular cooperativity was deduced using the methodology, resulting in an increased understanding of the interactions between self assembling molecules.

  13. Intrinsically irreversible heat engine

    DOEpatents

    Wheatley, J.C.; Swift, G.W.; Migliori, A.

    1984-01-01

    A class of heat engines based on an intrinsically irreversible heat transfer process is disclosed. In a typical embodiment the engine comprises a compressible fluid that is cyclically compressed and expanded while at the same time being driven in reciprocal motion by a positive displacement drive means. A second thermodynamic medium is maintained in imperfect thermal contact with the fluid and bears a broken thermodynamic symmetry with respect to the fluid. The second thermodynamic medium is a structure adapted to have a low fluid flow impedance with respect to the compressible fluid, and which is further adapted to be in only moderate thermal contact with the fluid. In operation, thermal energy is pumped along the second medium due to a phase lag between the cyclical heating and cooling of the fluid and the resulting heat conduction between the fluid and the medium. In a preferred embodiment the engine comprises an acoustical drive and a housing containing a gas which is driven at a resonant frequency so as to be maintained in a standing wave. Operation of the engine at acoustic frequencies improves the power density and coefficient of performance. The second thermodynamic medium can be coupled to suitable heat exchangers to utilize the engine as a simple refrigeration device having no mechanical moving parts. Alternatively, the engine is reversible in function so as to be utilizable as a prime mover by coupling it to suitable sources and sinks of heat.

  14. Intrinsically irreversible heat engine

    DOEpatents

    Wheatley, J.C.; Swift, G.W.; Migliori, A.

    1984-12-25

    A class of heat engines based on an intrinsically irreversible heat transfer process is disclosed. In a typical embodiment the engine comprises a compressible fluid that is cyclically compressed and expanded while at the same time being driven in reciprocal motion by a positive displacement drive means. A second thermodynamic medium is maintained in imperfect thermal contact with the fluid and bears a broken thermodynamic symmetry with respect to the fluid. The second thermodynamic medium is a structure adapted to have a low fluid flow impedance with respect to the compressible fluid, and which is further adapted to be in only moderate thermal contact with the fluid. In operation, thermal energy is pumped along the second medium due to a phase lag between the cyclical heating and cooling of the fluid and the resulting heat conduction between the fluid and the medium. In a preferred embodiment the engine comprises an acoustical drive and a housing containing a gas which is driven at a resonant frequency so as to be maintained in a standing wave. Operation of the engine at acoustic frequencies improves the power density and coefficient of performance. The second thermodynamic medium can be coupled to suitable heat exchangers to utilize the engine as a simple refrigeration device having no mechanical moving parts. Alternatively, the engine is reversible in function so as to be utilizable as a prime mover by coupling it to suitable sources and sinks of heat. 11 figs.

  15. Intrinsically irreversible heat engine

    DOEpatents

    Wheatley, John C.; Swift, Gregory W.; Migliori, Albert

    1984-01-01

    A class of heat engines based on an intrinsically irreversible heat transfer process is disclosed. In a typical embodiment the engine comprises a compressible fluid that is cyclically compressed and expanded while at the same time being driven in reciprocal motion by a positive displacement drive means. A second thermodynamic medium is maintained in imperfect thermal contact with the fluid and bears a broken thermodynamic symmetry with respect to the fluid. the second thermodynamic medium is a structure adapted to have a low fluid flow impedance with respect to the compressible fluid, and which is further adapted to be in only moderate thermal contact with the fluid. In operation, thermal energy is pumped along the second medium due to a phase lag between the cyclical heating and cooling of the fluid and the resulting heat conduction between the fluid and the medium. In a preferred embodiment the engine comprises an acoustical drive and a housing containing a gas which is driven at a resonant frequency so as to be maintained in a standing wave. Operation of the engine at acoustic frequencies improves the power density and coefficient of performance. The second thermodynamic medium can be coupled to suitable heat exchangers to utilize the engine as a simple refrigeration device having no mechanical moving parts. Alternatively, the engine is reversible in function so as to be utilizable as a prime mover by coupling it to suitable sources and sinks of heat.

  16. Intrinsic Angular Momentum of Light.

    ERIC Educational Resources Information Center

    Santarelli, Vincent

    1979-01-01

    Derives a familiar torque-angular momentum theorem for the electromagnetic field, and includes the intrinsic torques exerted by the fields on the polarized medium. This inclusion leads to the expressions for the intrinsic angular momentum carried by the radiation traveling through a charge-free medium. (Author/MA)

  17. The intrinsic resistance of bacteria.

    PubMed

    Gang, Zhang; Jie, Feng

    2016-10-20

    Antibiotic resistance is often considered to be a trait acquired by previously susceptible bacteria, on the basis of which can be attributed to the horizontal acquisition of new genes or the occurrence of spontaneous mutation. In addition to acquired resistance, bacteria have a trait of intrinsic resistance to different classes of antibiotics. An intrinsic resistance gene is involved in intrinsic resistance, and its presence in bacterial strains is independent of previous antibiotic exposure and is not caused by horizontal gene transfer. Recently, interest in intrinsic resistance genes has increased, because these gene products not only may provide attractive therapeutic targets for development of novel drugs that rejuvenate the activity of existing antibiotics, and but also might predict future emergence of resistant pathogens if they become mobilized. In the present review, we summarize the conventional examples of intrinsic resistance, including the impermeability of cellular envelopes, the activity of multidrug efflux pumps or lack of drug targets. We also demonstrate that transferases and enzymes involved in basic bacterial metabolic processes confer intrinsic resistance in Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. We present as well information on the cryptic intrinsic resistance genes that do not confer resistance to their native hosts but are capable of conferring resistance when their expression levels are increased and the activation of the cryptic genes. Finally, we discuss that intrinsic genes could be the origin of acquired resistance, especially in the genus Acinetobacter.

  18. Quantum collapse of a charged n-dimensional BTZ-like domain wall

    NASA Astrophysics Data System (ADS)

    Greenwood, Eric

    We investigate both the classical and quantum gravitational collapse of a massive, charged, nonrotating n-dimensional Bañados-Teitelboim-Zanelli (BTZ)-like domain wall in AdS space. In the classical picture, we show that, as far as the asymptotic observer is concerned, the details of the collapse depend on the amount of charge present in the domain wall; that is, if the domain wall is extremal, nonextremal or overcharged. In both the extremal and nonextremal cases, the collapse takes an infinite amount of observer time to complete. However, in the over-charged case, the collapse never actually occurs, instead one finds an oscillatory solution which prevents the formation of a naked singularity. As far as the infalling observer is concerned, in the nonextremal case, the collapse is completed within a finite amount of proper time. Thus, the gravitational collapse follows that of the typical formation of a black hole via gravitational collapse. Quantum mechanically, we take the absence of induced quasi-particle production and fluctuations of the metric geometry; that is, we ignore the effect of radiation and back-reaction. For the asymptotic observer, we find that, near the horizon, quantization of the domain wall does not allow the formation of the black hole in a finite amount of observer time. For the infalling observer, we are primarily interested in the quantum mechanical effect as the domain wall approaches the classical singularity. In this region, the main result is that the wave function exhibits nonlocal effects, demonstrated by the fact that the Hamiltonian depends on an infinite number of derivatives that cannot be truncated after a finite number of terms. Furthermore, in the large energy density limit, the wave function vanishes at the classical singularity implying that quantization does not rid the black hole of its singularity.

  19. ND2 AV: N-dimensional data analysis and visualization analysis for the National Ignition Campaign

    DOE PAGES

    Bremer, Peer -Timo; Maljovec, Dan; Saha, Avishek; ...

    2015-07-01

    Here, one of the biggest challenges in high-energy physics is to analyze a complex mix of experimental and simulation data to gain new insights into the underlying physics. Currently, this analysis relies primarily on the intuition of trained experts often using nothing more sophisticated than default scatter plots. Many advanced analysis techniques are not easily accessible to scientists and not flexible enough to explore the potentially interesting hypotheses in an intuitive manner. Furthermore, results from individual techniques are often difficult to integrate, leading to a confusing patchwork of analysis snippets too cumbersome for data exploration. This paper presents a case study on how a combination of techniques from statistics, machine learning, topology, and visualization can have a significant impact in the field of inertial confinement fusion. We present themore » $$\\mathrm{ND}^2\\mathrm{AV}$$: N-dimensional data analysis and visualization framework, a user-friendly tool aimed at exploiting the intuition and current workflow of the target users. The system integrates traditional analysis approaches such as dimension reduction and clustering with state-of-the-art techniques such as neighborhood graphs and topological analysis, and custom capabilities such as defining combined metrics on the fly. All components are linked into an interactive environment that enables an intuitive exploration of a wide variety of hypotheses while relating the results to concepts familiar to the users, such as scatter plots. $$\\mathrm{ND}^2\\mathrm{AV}$$ uses a modular design providing easy extensibility and customization for different applications. $$\\mathrm{ND}^2\\mathrm{AV}$$ is being actively used in the National Ignition Campaign and has already led to a number of unexpected discoveries.« less

  20. Recent progress on intrinsic charm

    NASA Astrophysics Data System (ADS)

    Hobbs, T. J.

    2017-03-01

    Over the past ˜10 years, the topic of the nucleon's nonperturbative or intrinsic charm (IC) content has enjoyed something of a renaissance, largely motivated by theoretical developments involving quark modelers and PDF-fitters. In this talk I will briefly describe the importance of intrinsic charm to various issues in high-energy phenomenology, and survey recent progress in constraining its overall normalization and contribution to the momentum sum rule of the nucleon. I end with the conclusion that progress on the side of calculation has now placed the onus on experiment to unambiguously resolve the proton's intrinsic charm component.

  1. Intrinsic magnetization of antiferromagnetic textures

    NASA Astrophysics Data System (ADS)

    Tveten, Erlend G.; Müller, Tristan; Linder, Jacob; Brataas, Arne

    2016-03-01

    Antiferromagnets (AFMs) exhibit intrinsic magnetization when the order parameter spatially varies. This intrinsic spin is present even at equilibrium and can be interpreted as a twisting of the homogeneous AFM into a state with a finite spin. Because magnetic moments couple directly to external magnetic fields, the intrinsic magnetization can alter the dynamics of antiferromagnetic textures under such influence. Starting from the discrete Heisenberg model, we derive the continuum limit of the free energy of AFMs in the exchange approximation and explicitly rederive that the spatial variation of the antiferromagnetic order parameter is associated with an intrinsic magnetization density. We calculate the magnetization profile of a domain wall and discuss how the intrinsic magnetization reacts to external forces. We show conclusively, both analytically and numerically, that a spatially inhomogeneous magnetic field can move and control the position of domain walls in AFMs. By comparing our model to a commonly used alternative parametrization procedure for the continuum fields, we show that the physical interpretations of these fields depend critically on the choice of parametrization procedure for the discrete-to-continuous transition. This can explain why a significant amount of recent studies of the dynamics of AFMs, including effective models that describe the motion of antiferromagnetic domain walls, have neglected the intrinsic spin of the textured order parameter.

  2. The Impact of Curiosity and External Regulation on Intrinsic Motivation: An Empirical Study in Hong Kong Education

    ERIC Educational Resources Information Center

    Hon-keung, Yau; Man-shan, Kan; Lai-fong, Cheng Alison

    2012-01-01

    The purposes of this paper are to identify: (1) the factors affecting the intrinsic motivation of university students in Hong Kong; and (2) gender differences in the perception of intrinsic motivation in Hong Kong higher education environment. The factors of curiosity and external regulation with intrinsic motivation are taken into investigation…

  3. Ulnar intrinsic anatomy and dysfunction.

    PubMed

    Dell, Paul C; Sforzo, Christopher R

    2005-01-01

    Normal hand function is a balance between the extrinsic and intrinsic musculature. Although individually the intrinsics are small muscles in diameter, collectively they represent a large muscle that contributes approximately 50% of grip strength. Dysfunction of the intrinsics consequently leads to impaired grip and pinch strength as well recognized deformities. Low ulnar nerve palsy preserves ulnar innervated extrinsics resulting in sensory loss, digital clawing, thumb deformity, abduction of the small finger, and asynchronous finger motion. High ulnar nerve palsy is characterized by the above plus paralysis of the ulnar profundi and the flexor carpi ulnaris. Understanding the normal anatomy allows the clinician to identify the site of the lesion and plan appropriate surgical intervention. This article revisits the classic work of Richard J. Smith on ulnar nerve palsy with contemporary perspective.

  4. ON THE GEOMETRY OF MEASURABLE SETS IN N-DIMENSIONAL SPACE ON WHICH GENERALIZED LOCALIZATION HOLDS FOR MULTIPLE FOURIER SERIES OF FUNCTIONS IN L_p, p>1

    NASA Astrophysics Data System (ADS)

    Bloshanskiĭ, I. L.

    1984-02-01

    The precise geometry is found of measurable sets in N-dimensional Euclidean space on which generalized localization almost everywhere holds for multiple Fourier series which are rectangularly summable.Bibliography: 14 titles.

  5. Existence and global exponential stability of periodic solutions for n-dimensional neutral dynamic equations on time scales.

    PubMed

    Li, Bing; Li, Yongkun; Zhang, Xuemei

    2016-01-01

    In this paper, by using the existence of the exponential dichotomy of linear dynamic equations on time scales and the theory of calculus on time scales, we study the existence and global exponential stability of periodic solutions for a class of n-dimensional neutral dynamic equations on time scales. We also present an example to illustrate the feasibility of our results. The results of this paper are completely new and complementary to the previously known results even in both the case of differential equations (time scale [Formula: see text]) and the case of difference equations (time scale [Formula: see text]).

  6. Perfectionism and life aspirations in intrinsically and extrinsically religious individuals.

    PubMed

    Steffen, Patrick R

    2014-08-01

    Religiosity is related to positive health and life satisfaction but the pathways through which this occurs have not been clearly delineated. The purpose of this study was to examine potential mediators of the relationships between intrinsic and extrinsic religiosity and negative affect and life satisfaction. Perfectionism and life aspirations are two possible pathways through which religious orientation is related to outcome. It was hypothesized that adaptive perfectionism and intrinsic life aspirations would act as mediators between intrinsic religiosity and negative affect and life satisfaction, and that maladaptive perfectionism and extrinsic life aspirations would act as mediators between the extrinsic religiosity and negative affect and life satisfaction. Two consecutive samples of religious college students (N = 540 and N = 485) completed measures of the Age Universal Religious Orientation Index, the Frost Multi-Dimensional Perfectionism Scale, the Aspiration Index, the Beck Depression Inventory-II, the Spielberger State-Trait Anxiety Inventory, and the Satisfaction with Life Scale. Intrinsic religiosity had a direct negative relationship with negative affect and positive relationship with life satisfaction. Contrary to the hypotheses, intrinsic religiosity had its strongest indirect effect via maladaptive perfectionism such that increased intrinsic religiosity was related to decreased maladaptive perfectionism which in turn lead to better negative affect and life satisfaction. Extrinsic religiosity was related to increased maladaptive perfectionism and thereby indirectly contributed to worse negative affect and life satisfaction. Interestingly, when the effects of maladaptive perfectionism were controlled, the direct effects of extrinsic religiosity were related to reduced negative affect and increased life satisfaction. Overall, the strongest mediator in this study of both intrinsic and extrinsic religiosity was maladaptive perfectionism, with intrinsic

  7. Individual Patterns in Intrinsic Motivation.

    ERIC Educational Resources Information Center

    Hom, Harry L., Jr.; Maxwell, Frederick R.

    The effects of extrinsic reward on students' intrinsic interest was investigated using a single-subject design in a behavior disorders classroom. Baseline measures of the interest level of five children (ages 9-11 years) were collected for academic and non-academic tasks. Assessment was then made of each subject's response hierarchy or level of…

  8. Stimuli-sensitive intrinsically disordered protein brushes

    NASA Astrophysics Data System (ADS)

    Srinivasan, Nithya; Bhagawati, Maniraj; Ananthanarayanan, Badriprasad; Kumar, Sanjay

    2014-10-01

    Grafting polymers onto surfaces at high density to yield polymer brush coatings is a widely employed strategy to reduce biofouling and interfacial friction. These brushes almost universally feature synthetic polymers, which are often heterogeneous and do not readily allow incorporation of chemical functionalities at precise sites along the constituent chains. To complement these synthetic systems, we introduce a biomimetic, recombinant intrinsically disordered protein that can assemble into an environment-sensitive brush. This macromolecule adopts an extended conformation and can be grafted to solid supports to form oriented protein brushes that swell and collapse dramatically with changes in solution pH and ionic strength. We illustrate the value of sequence specificity by using proteases with mutually orthogonal recognition sites to modulate brush height in situ to predictable values. This study demonstrates that stimuli-responsive brushes can be fabricated from proteins and introduces them as a new class of smart biomaterial building blocks.

  9. Thermodynamic geometry and thermal stability of n -dimensional dilaton black holes in the presence of logarithmic nonlinear electrodynamics

    NASA Astrophysics Data System (ADS)

    Sheykhi, A.; Naeimipour, F.; Zebarjad, S. M.

    2015-12-01

    In this paper, we construct a new class of black hole solutions which is coupled to the logarithmic nonlinear electrodynamics in the context of dilaton gravity. We consider an n -dimensional action in which gravity is coupled to the logarithmic nonlinear electrodynamics field and a scalar dilaton field to obtain the equations of motion of the gravitational, dilaton and electromagnetic fields. This leads to finding a new class of n -dimensional static and spherically symmetric black hole solutions in the presence of two Liouville-type dilaton potentials. The asymptotic behavior of these solutions is neither flat nor (anti-)de Sitter [(A)dS], and in the limiting case where the nonlinear parameter β goes to infinity, our solutions reduce to the black holes of Einstein-Maxwell-dilaton gravity in higher dimensions. Thermodynamic quantities such as mass, temperature, electric potential and entropy are also computed, and it is shown that they agree with the first law of thermodynamics. Furthermore, we find that for small values of the electric charge parameter q , and the dilaton coupling constant α , as well as small dimension n , the solutions are thermally stable. By increasing n , the region of stability stands for smaller values of α independent of q . Finally, we use the method of thermodynamical geometry and find the phase transition points by calculating the Ricci scalar of a thermodynamic metric.

  10. Intrinsic randomness and intrinsic irreversibility in classical dynamical systems

    PubMed Central

    Courbage, M.; Prigogine, I.

    1983-01-01

    We continue our previous work on dynamic “intrinsically random” systems for which we can derive dissipative Markov processes through a one-to-one change of representation. For these systems, the unitary group of evolution can be transformed in this way into two distinct Markov processes leading to equilibrium for either t→ + ∞ or t→ - ∞. To lift the degeneracy, we first formulate the second principle as a selection rule that is meaningful in intrinsically random systems. For these systems, this excludes a set of unrealizable states. As a result of this exclusion, permitted initial conditions correspond to a set of states that is not invariant through velocity inversion. In this way, the time-reversal symmetry of dynamics is broken and these systems acquire a new feature we may call “intrinsic irreversibility.” The set of admitted initial conditions can be characterized by an entropy displaying the amount of information necessary for their preparation. The initial conditions selected by the second law correspond to a finite amount of information, while the initial conditions that are rejected correspond to an infinite amount of information and are therefore “impossible.” We believe that our formulation permits a microscopic formulation of the second law of thermodynamics for well-defined classes of dynamical systems. PMID:16578774

  11. Quasar redshifts: the intrinsic component

    NASA Astrophysics Data System (ADS)

    Hansen, Peter M.

    2016-09-01

    The large observed redshift of quasars has suggested large cosmological distances and a corresponding enormous energy output to explain the brightness or luminosity as seen at earth. Alternative or complementary sources of redshift have not been identified by the astronomical community. This study examines one possible source of additional redshift: an intrinsic component based on the plasma characteristics of high temperature and high electron density which are believed to be present.

  12. Nuclear Filtering of Intrinsic Charm

    SciTech Connect

    Kopeliovich, B. Z.; Potashnikova, I. K.; Schmidt, Ivan

    2010-11-12

    Nuclei are transparent for a heavy intrinsic charm (IC) component of the beam hadrons, what leads to an enhanced nuclear dependence of open charm production at large Feynman x{sub F}. Indeed, such an effect is supported by data from the SELEX experiment published recently [1]. Our calculations reproduce well the data, providing strong support for the presence of IC in hadrons in amount less than 1%. Moreover, we performed an analysis of nuclear effects in J/{Psi} production and found at large x{sub F} a similar, albeit weaker effect, which does not contradict data.

  13. Intrinsically disordered proteins and intrinsically disordered protein regions.

    PubMed

    Oldfield, Christopher J; Dunker, A Keith

    2014-01-01

    Intrinsically disordered proteins (IDPs) and IDP regions fail to form a stable structure, yet they exhibit biological activities. Their mobile flexibility and structural instability are encoded by their amino acid sequences. They recognize proteins, nucleic acids, and other types of partners; they accelerate interactions and chemical reactions between bound partners; and they help accommodate posttranslational modifications, alternative splicing, protein fusions, and insertions or deletions. Overall, IDP-associated biological activities complement those of structured proteins. Recently, there has been an explosion of studies on IDP regions and their functions, yet the discovery and investigation of these proteins have a long, mostly ignored history. Along with recent discoveries, we present several early examples and the mechanisms by which IDPs contribute to function, which we hope will encourage comprehensive discussion of IDPs and IDP regions in biochemistry textbooks. Finally, we propose future directions for IDP research.

  14. Intrinsic ferroelectric switching from first principles

    NASA Astrophysics Data System (ADS)

    Liu, Shi; Grinberg, Ilya; Rappe, Andrew M.

    2016-06-01

    The existence of domain walls, which separate regions of different polarization, can influence the dielectric, piezoelectric, pyroelectric and electronic properties of ferroelectric materials. In particular, domain-wall motion is crucial for polarization switching, which is characterized by the hysteresis loop that is a signature feature of ferroelectric materials. Experimentally, the observed dynamics of polarization switching and domain-wall motion are usually explained as the behaviour of an elastic interface pinned by a random potential that is generated by defects, which appear to be strongly sample-dependent and affected by various elastic, microstructural and other extrinsic effects. Theoretically, connecting the zero-kelvin, first-principles-based, microscopic quantities of a sample with finite-temperature, macroscopic properties such as the coercive field is critical for material design and device performance; and the lack of such a connection has prevented the use of techniques based on ab initio calculations for high-throughput computational materials discovery. Here we use molecular dynamics simulations of 90° domain walls (separating domains with orthogonal polarization directions) in the ferroelectric material PbTiO3 to provide microscopic insights that enable the construction of a simple, universal, nucleation-and-growth-based analytical model that quantifies the dynamics of many types of domain walls in various ferroelectrics. We then predict the temperature and frequency dependence of hysteresis loops and coercive fields at finite temperatures from first principles. We find that, even in the absence of defects, the intrinsic temperature and field dependence of the domain-wall velocity can be described with a nonlinear creep-like region and a depinning-like region. Our model enables quantitative estimation of coercive fields, which agree well with experimental results for ceramics and thin films. This agreement between model and experiment suggests

  15. Intrinsic ferroelectric switching from first principles.

    PubMed

    Liu, Shi; Grinberg, Ilya; Rappe, Andrew M

    2016-06-16

    The existence of domain walls, which separate regions of different polarization, can influence the dielectric, piezoelectric, pyroelectric and electronic properties of ferroelectric materials. In particular, domain-wall motion is crucial for polarization switching, which is characterized by the hysteresis loop that is a signature feature of ferroelectric materials. Experimentally, the observed dynamics of polarization switching and domain-wall motion are usually explained as the behaviour of an elastic interface pinned by a random potential that is generated by defects, which appear to be strongly sample-dependent and affected by various elastic, microstructural and other extrinsic effects. Theoretically, connecting the zero-kelvin, first-principles-based, microscopic quantities of a sample with finite-temperature, macroscopic properties such as the coercive field is critical for material design and device performance; and the lack of such a connection has prevented the use of techniques based on ab initio calculations for high-throughput computational materials discovery. Here we use molecular dynamics simulations of 90° domain walls (separating domains with orthogonal polarization directions) in the ferroelectric material PbTiO3 to provide microscopic insights that enable the construction of a simple, universal, nucleation-and-growth-based analytical model that quantifies the dynamics of many types of domain walls in various ferroelectrics. We then predict the temperature and frequency dependence of hysteresis loops and coercive fields at finite temperatures from first principles. We find that, even in the absence of defects, the intrinsic temperature and field dependence of the domain-wall velocity can be described with a nonlinear creep-like region and a depinning-like region. Our model enables quantitative estimation of coercive fields, which agree well with experimental results for ceramics and thin films. This agreement between model and experiment suggests

  16. Intrinsic optimization using stochastic nanomagnets

    NASA Astrophysics Data System (ADS)

    Sutton, Brian; Camsari, Kerem Yunus; Behin-Aein, Behtash; Datta, Supriyo

    2017-03-01

    This paper draws attention to a hardware system which can be engineered so that its intrinsic physics is described by the generalized Ising model and can encode the solution to many important NP-hard problems as its ground state. The basic constituents are stochastic nanomagnets which switch randomly between the ±1 Ising states and can be monitored continuously with standard electronics. Their mutual interactions can be short or long range, and their strengths can be reconfigured as needed to solve specific problems and to anneal the system at room temperature. The natural laws of statistical mechanics guide the network of stochastic nanomagnets at GHz speeds through the collective states with an emphasis on the low energy states that represent optimal solutions. As proof-of-concept, we present simulation results for standard NP-complete examples including a 16-city traveling salesman problem using experimentally benchmarked models for spin-transfer torque driven stochastic nanomagnets.

  17. Intrinsic optimization using stochastic nanomagnets

    PubMed Central

    Sutton, Brian; Camsari, Kerem Yunus; Behin-Aein, Behtash; Datta, Supriyo

    2017-01-01

    This paper draws attention to a hardware system which can be engineered so that its intrinsic physics is described by the generalized Ising model and can encode the solution to many important NP-hard problems as its ground state. The basic constituents are stochastic nanomagnets which switch randomly between the ±1 Ising states and can be monitored continuously with standard electronics. Their mutual interactions can be short or long range, and their strengths can be reconfigured as needed to solve specific problems and to anneal the system at room temperature. The natural laws of statistical mechanics guide the network of stochastic nanomagnets at GHz speeds through the collective states with an emphasis on the low energy states that represent optimal solutions. As proof-of-concept, we present simulation results for standard NP-complete examples including a 16-city traveling salesman problem using experimentally benchmarked models for spin-transfer torque driven stochastic nanomagnets. PMID:28295053

  18. Profibus features intrinsic safety, interoperability

    SciTech Connect

    Bryant, M.

    1996-11-01

    The newest member of the Profibus (process fieldbus) family of interoperable field-bus protocols is {open_quotes}PA{close_quotes}, an intrinsically safe (IS) standard released more than a year ago. IS and non-IS plants using PA for process chemicals, energy production, and food manufacturing are coming online. PA was developed by vendor and user members of the Profibus standards community to meet the needs of customers in the process industries. PA complies with IEC 1158-2, which, among non-IS capabilities, specifies a low-speed, intrinsically safe fieldbus for automating explosive chemical manufacturing. PA thus provides all H1, or {open_quotes}hunk{close_quotes} 1, IS and non-IS services. Importantly, it also provides all H2, or {open_quotes}hunk{close_quotes} 2, services. As the newest segment of the site-proven system of fieldbus protocols, Profibus-PA defines by example the concepts of interoperability and interchangeability. It is a field instrument network that automatically interoperates with a large installed base of fieldbus nodes. As low-speed networks, PA and its competitor, Foundation fieldbus H1 comply with the same standard. They do the same job; auxiliary power to the application, with a data rate of 31.25 kbit/sec. Similarities include a function-block-based architecture and a device description language (DDL). They use the same physical layer for digital data transfer. A casual observer would find PA and H1 virtually the same. The key differences are in the protocol implementations. Although PA and H1 could be wired together, the messages delivered by one would make no sense to the other. At least not yet. PA protocols are capable of both IS and non-IS operations. This opens the door to a wide range of interoperable process-manufacturing requirements. 1 fig., 1 tab.

  19. Back to the Definitions Themselves: The Pragmatics of Intrinsic Justification.

    ERIC Educational Resources Information Center

    Bahm, Kenneth

    Such terms as "intrinsic justification,""intrinsicness," and "intrinsicality" are increasingly being heard in academic debate circles. Intrinsic justification consists of an argument which focuses evaluation of a resolutional term on the term's definitional contours. Essential qualities are defining characteristics…

  20. Buying into conservation: intrinsic versus instrumental value.

    PubMed

    Justus, James; Colyvan, Mark; Regan, Helen; Maguire, Lynn

    2009-04-01

    Many conservation biologists believe the best ethical basis for conserving natural entities is their claimed intrinsic value, not their instrumental value for humans. But there is significant confusion about what intrinsic value is and how it could govern conservation decision making. After examining what intrinsic value is supposed to be, we argue that it cannot guide the decision making conservation requires. An adequate ethical basis for conservation must do this, and instrumental value does it best.

  1. Issues in Purchasing and Maintaining Intrinsic Standards

    SciTech Connect

    PETTIT,RICHARD B.; JAEGER,KLAUS; EHRLICH,CHARLES D.

    2000-09-12

    Intrinsic standards are widely used in the metrology community because they realize the best level uncertainty for many metrology parameters. For some intrinsic standards, recommended practices have been developed to assist metrologists in the selection of equipment and the development of appropriate procedures in order to realize the intrinsic standard. As with the addition of any new standard, the metrology laboratory should consider the pros and cons relative to their needs before purchasing the standard so that the laboratory obtains the maximum benefit from setting up and maintaining these standards. While the specific issues that need to be addressed depend upon the specific intrinsic standard and the level of realization, general issues that should be considered include ensuring that the intrinsic standard is compatible with the laboratory environment, that the standard is compatible with the current and future workload, and whether additional support standards will be required in order to properly maintain the intrinsic standard. When intrinsic standards are used to realize the best level of uncertainty for a specific metrology parameter, they usually require critical and important maintenance activities. These activities can including training of staff in the system operation, as well as safety procedures; performing periodic characterization measurements to ensure proper system operation; carrying out periodic intercomparisons with similar intrinsic standards so that proper operation is demonstrated; and maintaining control or trend charts of system performance. This paper has summarized many of these important issues and therefore should be beneficial to any laboratory that is considering the purchase of an intrinsic standard.

  2. Intrinsic Localized Modes in Proteins

    PubMed Central

    Nicolaï, Adrien; Delarue, Patrice; Senet, Patrick

    2015-01-01

    Protein dynamics is essential for proteins to function. Here we predicted the existence of rare, large nonlinear excitations, termed intrinsic localized modes (ILMs), of the main chain of proteins based on all-atom molecular dynamics simulations of two fast-folder proteins and of a rigid α/β protein at 300 K and at 380 K in solution. These nonlinear excitations arise from the anharmonicity of the protein dynamics. The ILMs were detected by computing the Shannon entropy of the protein main-chain fluctuations. In the non-native state (significantly explored at 380 K), the probability of their excitation was increased by a factor between 9 and 28 for the fast-folder proteins and by a factor 2 for the rigid protein. This enhancement in the non-native state was due to glycine, as demonstrated by simulations in which glycine was mutated to alanine. These ILMs might play a functional role in the flexible regions of proteins and in proteins in a non-native state (i.e. misfolded or unfolded states). PMID:26658321

  3. Intrinsic Tamper Indicating Device (TID) Program

    SciTech Connect

    Haag, W.E.

    1996-09-01

    The Los Alamos National Laboratory (LANL) Intrinsic Tamper Indicating Device (TID) Program has recently been developed in conjunction with the regular LANL TID Program to assist groups who perform measurements using sealed sources or store difficult-to-measure items. The program was then expanded to include other types of sealed sources and items processed for long-term storage in the Nuclear Material Packaging and Repackaging Program. The Intrinsic TID Program encompasses both Special Nuclear Material (SNM) and Nuclear Material (NM) items that have intrinsic characteristics that would immediately indicate tampering upon visual inspection. Items determined to be intrinsically sealed do not need to be sealed with authorized tamper indicating devices. Under the program, an identified intrinsic item receives the same safeguards credits as other tamper-sealed items already in the TID Program. The major benefits of the Intrinsic TID Program include reducing verification measurements on intrinsically identified inventory items and reducing exposure to operators working in highly irradiated environments. Intrinsic TIDs should be combined with other safeguards requirements, and items should have defensible measurements as well as visual inspections. Several groups at LANL are already implementing the program and providing feedback so that we can tailor it to better meet the customers` needs.

  4. Intrinsic bioremediation of landfills interim report

    SciTech Connect

    Brigmon, R.L.; Fliermans, C.B.

    1997-07-14

    Intrinsic bioremediation is a risk management option that relies on natural biological and physical processes to contain the spread of contamination from a source. Evidence is presented in this report that intrinsic bioremediation is occurring at the Sanitary Landfill is fundamental to support incorportion into a Corrective Action Plan (CAP).

  5. Development of Intrinsically Photoluminescent and Photostable Polylactones

    PubMed Central

    Xie, Zhiwei; Zhang, Yi; Liu, Li; Weng, Hong; Mason, Ralph P.; Tang, Liping; Nguyen, Kytai T.; Hsieh, Jer-Tsong

    2014-01-01

    A method of introducing intrinsically photoluminescent properties to biodegradable polymer was introduced, exemplified by the synthesis of intrinsically photoluminescent polylactones that enable non-invasively monitoring and tracking material degradation in vivo in real-time and the formation of theranostic nanoparticles for cancer imaging and drug delivery. PMID:24668888

  6. ND2 AV: N-dimensional data analysis and visualization analysis for the National Ignition Campaign

    SciTech Connect

    Bremer, Peer -Timo; Maljovec, Dan; Saha, Avishek; Wang, Bei; Gaffney, Jim; Spears, Brian K.; Pascucci, Valerio

    2015-07-01

    Here, one of the biggest challenges in high-energy physics is to analyze a complex mix of experimental and simulation data to gain new insights into the underlying physics. Currently, this analysis relies primarily on the intuition of trained experts often using nothing more sophisticated than default scatter plots. Many advanced analysis techniques are not easily accessible to scientists and not flexible enough to explore the potentially interesting hypotheses in an intuitive manner. Furthermore, results from individual techniques are often difficult to integrate, leading to a confusing patchwork of analysis snippets too cumbersome for data exploration. This paper presents a case study on how a combination of techniques from statistics, machine learning, topology, and visualization can have a significant impact in the field of inertial confinement fusion. We present the $\\mathrm{ND}^2\\mathrm{AV}$: N-dimensional data analysis and visualization framework, a user-friendly tool aimed at exploiting the intuition and current workflow of the target users. The system integrates traditional analysis approaches such as dimension reduction and clustering with state-of-the-art techniques such as neighborhood graphs and topological analysis, and custom capabilities such as defining combined metrics on the fly. All components are linked into an interactive environment that enables an intuitive exploration of a wide variety of hypotheses while relating the results to concepts familiar to the users, such as scatter plots. $\\mathrm{ND}^2\\mathrm{AV}$ uses a modular design providing easy extensibility and customization for different applications. $\\mathrm{ND}^2\\mathrm{AV}$ is being actively used in the National Ignition Campaign and has already led to a number of unexpected discoveries.

  7. Intrinsic decoherence in isolated quantum systems

    NASA Astrophysics Data System (ADS)

    Wu, Yang-Le; Deng, Dong-Ling; Li, Xiaopeng; Das Sarma, S.

    2017-01-01

    We study the intrinsic, disorder-induced decoherence of an isolated quantum system under its own dynamics. Specifically, we investigate the characteristic time scale (i.e., the decoherence time) associated with an interacting many-body system losing the memory of its initial state. To characterize the erasure of the initial state memory, we define a time scale, the intrinsic decoherence time, by thresholding the gradual decay of the disorder-averaged return probability. We demonstrate the system-size independence of the intrinsic decoherence time in different models, and we study its dependence on the disorder strength. We find that the intrinsic decoherence time increases monotonically as the disorder strength increases in accordance with the relaxation of locally measurable quantities. We investigate several interacting spin (e.g., Ising and Heisenberg) and fermion (e.g., Anderson and Aubry-André) models to obtain the intrinsic decoherence time as a function of disorder and interaction strength.

  8. A new approach to: (a) grid generation for numerical optimization, and (b) interconnect networks for beowulf clusters, leveraging n-dimensional sphere-packings

    NASA Astrophysics Data System (ADS)

    Bewley, Thomas; Cessna, Joseph; Belitz, Paul

    2008-11-01

    The abstract field of n-dimensional sphere packing theory is well developed (for a comprehensive review, see Sphere Packings, Lattices and Groups by Conway and Sloane). This theory forms the theoretical underpinning of the error-correcting codes used in both deep space communications and in computer memory. The present work extends this elegant theory to two important and immensely practical problems in computational fluid dynamics: (a) the generation of efficient grids for the coordination of grid-based derivative-free optimization algorithms in n dimensions, and (b) the effective n-dimensional interconnection of massively-parallel clusters of computational nodes. As we will illustrate and quantify, the first problem benefits tremendously from dense sphere packings with large kissing numbers >> 2n, whereas the latter problem benefits tremendously from rare sphere packings with kissing number = n+1.

  9. Intrinsic structure in Saturn's rings

    NASA Astrophysics Data System (ADS)

    Albers, N.

    2015-10-01

    Saturn's rings are the most prominent in our Solar system and one example of granular matter in space. Dominated by tides and inelastic collisions the system is highly flattened being almost 300000km wide while only tens of meters thick. Individual particles are composed of primarily water ice and range from microns to few tens of meters in size. Apparent patterns comprise ringlets, gaps, kinematic wakes, propellers, bending waves, and the winding spiral arms of density waves. These large-scale structures are perturbations foremost created by external as well as embedded moons. Observations made by the Cassini spacecraft currently in orbit around Saturn show these structures in unprecedented detail. But high-resolution measurements reveal the presence of small-scale structures throughout the system. These include self-gravity wakes (50-100m), overstable waves (100-300m), subkm structure at the A and B ring edges, "straw" and "ropy" structures (1-3km), and the C ring "ghosts". Most of these had not been anticipated and are found in perturbed regions, driven by resonances with external moons, where the system undergoes periodic phases of compression and relaxation that correlate with the presence of structure. High velocity dispersion and the presence of large clumps imply structure formation on time scales as short as one orbit (about 10 hours). The presence of these intrinsic structures is seemingly the response to varying local conditions such as internal density, optical depth, underlying particle size distribution, granular temperature, and distance from the central planet. Their abundance provides evidence for an active and dynamic ring system where aggregation and fragmentation are ongoing on orbital timescales. Thus a kinetic description of the rings may be more appropriate than the fluid one. I will present Cassini Ultraviolet Spectrometer (UVIS) High Speed Photometer (HSP) occultations, Voyager 1 and 2 Imaging Science Subsystem (ISS), and high

  10. Exact period-four solutions of a family of n-dimensional quadratic maps via harmonic balance and Gröbner bases.

    PubMed

    D'Amico, María Belén; Calandrini, Guillermo L

    2015-11-01

    Analytical solutions of the period-four orbits exhibited by a classical family of n-dimensional quadratic maps are presented. Exact expressions are obtained by applying harmonic balance and Gröbner bases to a single-input single-output representation of the system. A detailed study of a generalized scalar quadratic map and a well-known delayed logistic model is included for illustration. In the former example, conditions for the existence of bistability phenomenon are also introduced.

  11. N-dimensional measurement-device-independent quantum key distribution with N + 1 un-characterized sources: zero quantum-bit-error-rate case

    PubMed Central

    Hwang, Won-Young; Su, Hong-Yi; Bae, Joonwoo

    2016-01-01

    We study N-dimensional measurement-device-independent quantum-key-distribution protocol where one checking state is used. Only assuming that the checking state is a superposition of other N sources, we show that the protocol is secure in zero quantum-bit-error-rate case, suggesting possibility of the protocol. The method may be applied in other quantum information processing. PMID:27452275

  12. Transition Theory: A Novel Theory of the Universe Creation and Evolution

    NASA Astrophysics Data System (ADS)

    Vlachogiannis, J. G.

    2004-08-01

    This paper presents a novel theory attempting to point out the perpetual transition of Universe and natural systems progressing from Big Bang to endless Quenching. It defines the increase of speed-of-light and space-dimensions number according to Fibonacci sequence Moreover, it proofs that the Time in our Universe is composed of its changes and its representation in n-4 hidden dimensions of an n-dimensional Universe

  13. CECAM workshop on Intrinsically Disordered Proteins

    PubMed Central

    Rösner, Heike; Papaleo, Elena; Haxholm, Gitte W; Best, Robert B; Kragelund, Birthe B; Lindorff-Larsen, Kresten

    2014-01-01

    With the increasing need to integrate different areas of science in the study of intrinsically disordered proteins we arranged a meeting entitled “Intrinsically Disordered Proteins: Connecting Computation, Physics and Biology” in Zürich in September 2013. The aim of the meeting was to bring together scientists from a range of disciplines to provide a snapshot of the field, as well as to promote future interdisciplinary studies that link the fundamental physical and chemical properties of intrinsically disordered proteins with their biological function. A range of important topics were covered at the meeting including studies linking structural studies of intrinsically disordered proteins with their function, the effect of post-translational modifications, studies of folding-upon-binding, as well as presentation of a number of systems in which intrinsically disordered proteins play a central role in important biological processes. A recurring theme was how computation, including various forms of molecular simulations, can be integrated with experimental and theoretical studies to help understand the complex properties of intrinsically disordered proteins. With this Meeting Report we hope to give a brief overview of the inspiration obtained from presentations, discussions and conversation held at the workshop and point out possible future directions within the field of intrinsically disordered proteins.

  14. CECAM workshop on intrinsically disordered proteins

    PubMed Central

    Rösner, Heike; Papaleo, Elena; Haxholm, Gitte W; Best, Robert B; Kragelund, Birthe B; Lindorff-Larsen, Kresten

    2014-01-01

    With the increasing need to integrate different areas of science in the study of intrinsically disordered proteins we arranged a meeting entitled “Intrinsically Disordered Proteins: Connecting Computation, Physics and Biology” in Zürich in September 2013. The aim of the meeting was to bring together scientists from a range of disciplines to provide a snapshot of the field, as well as to promote future interdisciplinary studies that link the fundamental physical and chemical properties of intrinsically disordered proteins with their biological function. A range of important topics were covered at the meeting including studies linking structural studies of intrinsically disordered proteins with their function, the effect of post-translational modifications, studies of folding-upon-binding, as well as presentation of a number of systems in which intrinsically disordered proteins play a central role in important biological processes. A recurring theme was how computation, including various forms of molecular simulations, can be integrated with experimental and theoretical studies to help understand the complex properties of intrinsically disordered proteins. With this Meeting Report we hope to give a brief overview of the inspiration obtained from presentations, discussions and conversations held at the workshop and point out possible future directions within the field of intrinsically disordered proteins.

  15. Design Space Issues for Intrinsic Evolvable Hardware

    NASA Technical Reports Server (NTRS)

    Hereford, James; Gwaltney, David

    2004-01-01

    This paper discuss the problem of increased programming time for intrinsic evolvable hardware (EHW) as the complexity of the circuit grows. We develop equations for the size of the population, n, and the number of generations required for the population to converge, ngen, based on L, the length of the programming string. We show that the processing time of the computer becomes negligible for intrinsic EHW since the selection/crossover/mutation steps are only done once per generation, suggesting there is room for use of more complex evolutionary algorithms m intrinsic EHW. F i y , we review the state of the practice and discuss the notion of a system design approach for intrinsic EHW.

  16. Recovering intrinsic fluorescence by Monte Carlo modeling.

    PubMed

    Müller, Manfred; Hendriks, Benno H W

    2013-02-01

    We present a novel way to recover intrinsic fluorescence in turbid media based on Monte Carlo generated look-up tables and making use of a diffuse reflectance measurement taken at the same location. The method has been validated on various phantoms with known intrinsic fluorescence and is benchmarked against photon-migration methods. This new method combines more flexibility in the probe design with fast reconstruction and showed similar reconstruction accuracy as found in other reconstruction methods.

  17. Refining the intrinsic chimera flap: a review.

    PubMed

    Agarwal, Jayant P; Agarwal, Shailesh; Adler, Neta; Gottlieb, Lawrence J

    2009-10-01

    Reconstruction of complex tissue deficiencies in which each missing component is in a different spatial relationship to each other can be particularly challenging, especially in patients with limited recipient vessels. The chimera flap design is uniquely suited to reconstruct these deformities. Chimera flaps have been previously defined in many ways with 2 main categories: prefabricated or intrinsic. Herein we attempt to clarify the definition of a true intrinsic chimeric flap and provide examples of how these constructs provide a method for reconstruction of complex defects. The versatility of the intrinsic chimera flap and its procurement from 7 different vascular systems is described. A clarification of the definition of a true intrinsic chimera flap is described. In addition, construction of flaps from the lateral femoral circumflex, deep circumflex iliac, inferior gluteal, peroneal, subscapular, thoracodorsal, and radial arterial systems is described to showcase the versatility of these chimera flaps. A true intrinsic chimera flap must consist of more than a single tissue type. Each of the tissue components receives its blood flow from separate vascular branches or perforators that are connected to a single vascular source. These vascular branches must be of appropriate length to allow for insetting with 3-dimensional spatial freedom. There are a multitude of sites from which true intrinsic chimera flaps may be harvested.

  18. Stimulating Students' Intrinsic Motivation for Learning Chemistry through the Use of Context-Based Learning Modules

    ERIC Educational Resources Information Center

    Vaino, Katrin; Holbrook, Jack; Rannikmae, Miia

    2012-01-01

    This paper introduces a research project in which five chemistry teachers, working in cooperation with university researchers, implemented a new teaching approach using context-based modules specially designed to stimulate the intrinsic motivation of students. The intention was to induce change in chemistry teachers' teaching approach from more…

  19. The Effects of Blended Learning on the Intrinsic Motivation of Thai EFL Students

    ERIC Educational Resources Information Center

    Sucaromana, Usaporn

    2013-01-01

    The aim of this study is to compare the results of blended learning with face-to-face learning among university students studying English as a foreign language. The participants were separated by gender, and the following variables, intrinsic motivation for learning English, attitudes towards English as a subject, and satisfaction with the…

  20. Intrinsic spin and orbital angular momentum Hall effect.

    PubMed

    Zhang, S; Yang, Z

    2005-02-18

    A generalized definition of intrinsic and extrinsic transport coefficients is introduced. We show that transport coefficients from the intrinsic origin are solely determined by local electronic structure, and thus the intrinsic spin Hall effect is not a transport phenomenon. The intrinsic spin Hall current is always accompanied by an equal but opposite intrinsic orbital angular momentum Hall current. We prove that the intrinsic spin Hall effect does not induce a spin accumulation at the edge of the sample or near the interface.

  1. Intrinsic delay of permeable base transistor

    SciTech Connect

    Chen, Wenchao; Guo, Jing; So, Franky

    2014-07-28

    Permeable base transistors (PBTs) fabricated by vacuum deposition or solution process have the advantages of easy fabrication and low power operation and are a promising device structure for flexible electronics. Intrinsic delay of PBT, which characterizes the speed of the transistor, is investigated by solving the three-dimensional Poisson equation and drift-diffusion equation self-consistently using finite element method. Decreasing the emitter thickness lowers the intrinsic delay by improving on-current, and a thinner base is also preferred for low intrinsic delay because of fewer carriers in the base region at off-state. The intrinsic delay exponentially decreases as the emitter contact Schottky barrier height decreases, and it linearly depends on the carrier mobility. With an optimized emitter contact barrier height and device geometry, a sub-nano-second intrinsic delay can be achieved with a carrier mobility of ∼10 cm{sup 2}/V/s obtainable in solution processed indium gallium zinc oxide, which indicates the potential of solution processed PBTs for GHz operations.

  2. Intrinsic-extrinsic factors in sport motivation.

    PubMed

    Pedersen, Darhl M

    2002-10-01

    Participants were 83 students (36 men and 47 women). 10 intrinsic-extrinsic factors involved in sport motivation were obtained. The factors were generated from items obtained from the participants rather than items from the experimenter. This was done to avoid the possible influence of preconceptions on the part of the experimenter regarding what the final dimensions may be. Obtained motivational factors were Social Reinforcement, Fringe Benefits, Fame and Fortune, External Forces, Proving Oneself, Social Benefits, Mental Enrichment, Expression of Self, Sense of Accomplishment, and Self-enhancement. Each factor was referred to an intrinsic-extrinsic dimension to describe its relative position on that dimension. The order of the factors as listed indicates increasing intrinsic motivation. i.e., the first four factors were rated in the extrinsic range, whereas the remaining six were rated to be in the intrinsic range. Next, the participants rated the extent to which each of the various factors was involved in their decision to participate in sport activities. The pattern of use of the motivational factors was the same for both sexes except that men indicated greater use of the Fringe Benefits factor. Overall, the more intrinsic a sport motivation factor was rated, the more likely it was to be rated as a factor in actual sport participation.

  3. Genome-Wide Prediction of Intrinsic Disorder; Sequence Alignment of Intrinsically Disordered Proteins

    ERIC Educational Resources Information Center

    Midic, Uros

    2012-01-01

    Intrinsic disorder (ID) is defined as a lack of stable tertiary and/or secondary structure under physiological conditions in vitro. Intrinsically disordered proteins (IDPs) are highly abundant in nature. IDPs possess a number of crucial biological functions, being involved in regulation, recognition, signaling and control, e.g. their functional…

  4. Structure and intrinsic disorder in protein autoinhibition.

    PubMed

    Trudeau, Travis; Nassar, Roy; Cumberworth, Alexander; Wong, Eric T C; Woollard, Geoffrey; Gsponer, Jörg

    2013-03-05

    Autoinhibition plays a significant role in the regulation of many proteins. By analyzing autoinhibited proteins, we demonstrate that these proteins are enriched in intrinsic disorder because of the properties of their inhibitory modules (IMs). A comparison of autoinhibited proteins with structured and intrinsically disordered IMs revealed that in the latter group (1) multiple phosphorylation sites are highly abundant; (2) splice variants occur in greater number than in their structured cousins; and (3) activation is often associated with changes in secondary structure in the IM. Analyses of families of autoinhibited proteins revealed that the levels of disorder in IMs can vary significantly throughout homologous proteins, whereas residues located at the interfaces between the IMs and inhibited domains are conserved. Our findings suggest that intrinsically disordered IMs provide advantages over structured ones that are likely to be exploited in the fine-tuning of the equilibrium between active and inactive states of autoinhibited proteins.

  5. Intrinsic Probability of a Multifractal Set

    NASA Astrophysics Data System (ADS)

    Hosokawa, Iwao

    1991-12-01

    It is shown that a self-similar measure isotropically distributed in a d-dimensional set should have its own intermittency exponents equivalent to its own generalized dimensions (in the sense of Hentschel and Procaccia), and that the intermittency exponents are completely designated by an intrinsic probability which governs the spatial distribution of the measure. Based on this, it is proven that the intrinsic probability uniquely determines the spatial distribution of the scaling index α of the measure as well as the so-called f-α spectrum of the multifractal set.

  6. Bootstrapped models for intrinsic random functions

    SciTech Connect

    Campbell, K.

    1988-08-01

    Use of intrinsic random function stochastic models as a basis for estimation in geostatistical work requires the identification of the generalized covariance function of the underlying process. The fact that this function has to be estimated from data introduces an additional source of error into predictions based on the model. This paper develops the sample reuse procedure called the bootstrap in the context of intrinsic random functions to obtain realistic estimates of these errors. Simulation results support the conclusion that bootstrap distributions of functionals of the process, as well as their kriging variance, provide a reasonable picture of variability introduced by imperfect estimation of the generalized covariance function.

  7. Bootstrapped models for intrinsic random functions

    SciTech Connect

    Campbell, K.

    1987-01-01

    The use of intrinsic random function stochastic models as a basis for estimation in geostatistical work requires the identification of the generalized covariance function of the underlying process, and the fact that this function has to be estimated from the data introduces an additional source of error into predictions based on the model. This paper develops the sample reuse procedure called the ''bootstrap'' in the context of intrinsic random functions to obtain realistic estimates of these errors. Simulation results support the conclusion that bootstrap distributions of functionals of the process, as well as of their ''kriging variance,'' provide a reasonable picture of the variability introduced by imperfect estimation of the generalized covariance function.

  8. The intrinsic quasar luminosity function: Accounting for accretion disk anisotropy

    SciTech Connect

    DiPompeo, M. A.; Myers, A. D.; Brotherton, M. S.; Runnoe, J. C.; Green, R. F.

    2014-05-20

    Quasar luminosity functions are a fundamental probe of the growth and evolution of supermassive black holes. Measuring the intrinsic luminosity function is difficult in practice, due to a multitude of observational and systematic effects. As sample sizes increase and measurement errors drop, characterizing the systematic effects is becoming more important. It is well known that the continuum emission from the accretion disk of quasars is anisotropic—in part due to its disk-like structure—but current luminosity function calculations effectively assume isotropy over the range of unobscured lines of sight. Here, we provide the first steps in characterizing the effect of random quasar orientations and simple models of anisotropy on observed luminosity functions. We find that the effect of orientation is not insignificant and exceeds other potential corrections such as those from gravitational lensing of foreground structures. We argue that current observational constraints may overestimate the intrinsic luminosity function by as much as a factor of ∼2 on the bright end. This has implications for models of quasars and their role in the universe, such as quasars' contribution to cosmological backgrounds.

  9. Organisational Learning and Employees' Intrinsic Motivation

    ERIC Educational Resources Information Center

    Remedios, Richard; Boreham, Nick

    2004-01-01

    This study examined the effects of organisational learning initiatives on employee motivation. Four initiatives consistent with theories of organisational learning were a priori ranked in terms of concepts that underpin intrinsic-motivation theory. Eighteen employees in a UK petrochemical company were interviewed to ascertain their experiences of…

  10. Intrinsic Factors Affecting Overseas Student Teaching

    ERIC Educational Resources Information Center

    Firmin, Michael W.; MacKay, Brenda B.; Firmin, Ruth L.

    2007-01-01

    We conducted a qualitative research study involving 13 undergraduate students who completed their student-teaching in overseas contexts. Participants completed two waves of interviews immediately after returning to campus from their multicultural experiences. Three intrinsic factors were found to have the greatest impact on students' overseas…

  11. Intrinsic and Extrinsic Motivation among Collegiate Instrumentalists

    ERIC Educational Resources Information Center

    Diaz, Frank M.

    2010-01-01

    The purpose of this study was to gather and compare information on measures of intrinsic and extrinsic motivation among instrumentalists enrolled in collegiate ensembles. A survey instrument was developed to gather information concerning demographic data and responses to questions on motivational preference. Participants were undergraduate and…

  12. Electroneutral intrinsic point defects in cadmium chalcogenides

    SciTech Connect

    Kharif, Ya.L.; Kudryashov, N.I.; Strunilina, T.A.

    1987-12-01

    Low-mobility electrically neutral intrinsic point defects were observed in cadmium chalcogenides. It was shown that the concentration of these defects is proportional to the cadmium vapor pressure to the 1/3 power at a constant temperature, and a mechanism for the formation of these defects were proposed.

  13. Simple intrinsic defects in InAs :

    SciTech Connect

    Schultz, Peter Andrew

    2013-03-01

    This Report presents numerical tables summarizing properties of intrinsic defects in indium arsenide, InAs, as computed by density functional theory using semi-local density functionals, intended for use as reference tables for a defect physics package in device models.

  14. Visual stimuli recruit intrinsically generated cortical ensembles.

    PubMed

    Miller, Jae-eun Kang; Ayzenshtat, Inbal; Carrillo-Reid, Luis; Yuste, Rafael

    2014-09-23

    The cortical microcircuit is built with recurrent excitatory connections, and it has long been suggested that the purpose of this design is to enable intrinsically driven reverberating activity. To understand the dynamics of neocortical intrinsic activity better, we performed two-photon calcium imaging of populations of neurons from the primary visual cortex of awake mice during visual stimulation and spontaneous activity. In both conditions, cortical activity is dominated by coactive groups of neurons, forming ensembles whose activation cannot be explained by the independent firing properties of their contributing neurons, considered in isolation. Moreover, individual neurons flexibly join multiple ensembles, vastly expanding the encoding potential of the circuit. Intriguingly, the same coactive ensembles can repeat spontaneously and in response to visual stimuli, indicating that stimulus-evoked responses arise from activating these intrinsic building blocks. Although the spatial properties of stimulus-driven and spontaneous ensembles are similar, spontaneous ensembles are active at random intervals, whereas visually evoked ensembles are time-locked to stimuli. We conclude that neuronal ensembles, built by the coactivation of flexible groups of neurons, are emergent functional units of cortical activity and propose that visual stimuli recruit intrinsically generated ensembles to represent visual attributes.

  15. Intrinsic novobiocin resistance in Staphylococcus saprophyticus.

    PubMed

    Vickers, Anna A; Chopra, Ian; O'Neill, Alex J

    2007-12-01

    Intrinsic novobiocin resistance in Staphylococcus saprophyticus was associated with expression of a novobiocin-resistant form of the drug target protein (GyrB). Site-directed mutagenesis established that resistance depends upon the presence of two specific amino acid residues in GyrB: a glycine at position 85 and a lysine at position 140.

  16. Frequent Major Changing: Extrinsic and Intrinsic Factors

    ERIC Educational Resources Information Center

    Firmin, Michael W.; MacKillop, Lisa M.

    2008-01-01

    Twenty undergraduates participated in individual, semi-structured interviews concerning their decisions to change majors. We found three common extrinsic and three intrinsic factors related to their decisions. Extrinsic factors included parents who were supportive but not meaningfully directive, lack of familial external guidance, and lack of…

  17. Sex Differences, Positive Feedback and Intrinsic Motivation.

    ERIC Educational Resources Information Center

    Deci, Edward L.; And Others

    The paper presents two experiments which test the "change in feelings of competence and self-determination" proposition of cognitive evaluation theory. This proposition states that when a person receives feedback about his performance on an intrinsically motivated activity this information will affect his sense of competence and…

  18. Intrinsic Motivation, Organizational Justice, and Creativity

    ERIC Educational Resources Information Center

    Hannam, Kalli; Narayan, Anupama

    2015-01-01

    For employees to generate creative ideas that are not only original, but also useful to their company, they must interact with their workplace environment to determine organizational needs. Therefore, it is important to consider aspects of the individual as well as their environment when studying creativity. Intrinsic motivation, a predictor of…

  19. Intrinsic Location Parameter of a Diffusion Process

    DTIC Science & Technology

    1998-03-18

    intrins�que du filtre de Kalman , discut�e dans un autre article. Nous pr�sentons ici une simulation num�rique dÕune EDS non lin�aire, qui montre la pr...the construction of an intrinsic nonlinear analog to the Kalman Fil- ter. We present here a numerical simulation of a nonlinear SDE, showing how well

  20. The Intrinsic Connectome of the Rat Amygdala

    PubMed Central

    Schmitt, Oliver; Eipert, Peter; Philipp, Konstanze; Kettlitz, Richard; Fuellen, Georg; Wree, Andreas

    2012-01-01

    The connectomes of nervous systems or parts there of are becoming important subjects of study as the amount of connectivity data increases. Because most tract-tracing studies are performed on the rat, we conducted a comprehensive analysis of the amygdala connectome of this species resulting in a meta-study. The data were imported into the neuroVIISAS system, where regions of the connectome are organized in a controlled ontology and network analysis can be performed. A weighted digraph represents the bilateral intrinsic (connections of regions of the amygdala) and extrinsic (connections of regions of the amygdala to non-amygdaloid regions) connectome of the amygdala. Its structure as well as its local and global network parameters depend on the arrangement of neuronal entities in the ontology. The intrinsic amygdala connectome is a small-world and scale-free network. The anterior cortical nucleus (72 in- and out-going edges), the posterior nucleus (45), and the anterior basomedial nucleus (44) are the nuclear regions that posses most in- and outdegrees. The posterior nucleus turns out to be the most important nucleus of the intrinsic amygdala network since its Shapley rate is minimal. Within the intrinsic amygdala, regions were determined that are essential for network integrity. These regions are important for behavioral (processing of emotions and motivation) and functional (memory) performances of the amygdala as reported in other studies. PMID:23248583

  1. Effects of Reinforcemnt Programs on Intrinsic Motivation.

    ERIC Educational Resources Information Center

    Sushinsky, Leonard W.

    Attribution Theory has led to predictions that the use of material reward may impair intrinsic motivation in the rewarded activity (decreased play effects). A review of the pertinent literature reveals, however, (a) that attribution research has failed to reliably demonstrate that decreased play effects occur in minimal-trial studies (b) that for…

  2. Advancing polymers of intrinsic microporosity by mechanochemistry

    DOE PAGES

    Zhang, Pengfei; Jiang, Xueguang; Wan, Shun; ...

    2015-01-01

    Herein, we report a fast (15 min) and solvent-free mechanochemical approach to construct polymers of intrinsic microporosity (PIMs) with high molecular mass and low polydispersity by solid grinding. The enhanced reaction efficiency results from the instantaneous frictional heating and continuous exposure of active sites within those solid reactants.

  3. High School Vocational Education: An Intrinsic Perspective.

    ERIC Educational Resources Information Center

    Silberman, Harry F.

    1979-01-01

    Presents two perspectives on the nature of vocational education: (1) that benefits are "extrinsic," that is, rewards are deferred until after graduation; and (2) that benefits are "intrinsic," that is, vocational education serves to promote full human development by exposing the learner to significant in-class experiences. (DR)

  4. Frustration-induced protein intrinsic disorder

    NASA Astrophysics Data System (ADS)

    Matsushita, Katsuyoshi; Kikuchi, Macoto

    2013-03-01

    Spontaneous folding into a specific native structure is the most important property of protein to perform their biological functions within organisms. Spontaneous folding is understood on the basis of an energy landscape picture based on the minimum frustration principle. Therefore, frustration seemingly only leads to protein functional disorder. However, frustration has recently been suggested to have a function in allosteric regulation. Functional frustration has the possibility to be a key to our deeper understanding of protein function. To explore another functional frustration, we theoretically examined structural frustration, which is designed to induce intrinsic disorder of a protein and its function through the coupled folding and binding. We extended the Wako-Saitô-Muñoz-Eaton model to take into account a frustration effect. With the model, we analyzed the binding part of neuron-restrictive silencer factor and showed that designed structural frustration in it induces intrinsic disorder. Furthermore, we showed that the folding and the binding are cooperative in interacting with a target protein. The cooperativity enables an intrinsically disordered protein to exhibit a sharp switch-like folding response to binding chemical potential change. Through this switch-like response, the structural frustration may contribute to the regulation function of interprotein interaction of the intrinsically disordered protein.

  5. [From physics to biology: the intrinsic dynamics of the cosmos].

    PubMed

    González de Posada, Francisco

    2003-01-01

    The History of Universe is described in an extremely summarized manner through the use of graphics, from Big bang until today. This is done according to the most recent standard models of Cosmology and Physics of elementary particles; in other words, according to those fields in Physics of a presupposed universal reference. The History of Life is immersed in this universal physical context, in a frame where our knowledge from Geology and Biology can be only terrestrial. The underlying ideas we try to arise are: 1) the transition from a relatively elementary structure to a posterior and a relatively more complex one requires some very special "environmental" conditions; and 2) the new structure can not be described only through its materic constituents, because in cosmic dynamicity new structures and new relationships (of intrinsic respectivity) arise, together with new laws (of extrinsic respectivity). Consequently and as an objective, physical knowledge (for example, elementary particles or atoms) alone in no way can explain biological reality (for example, cell or man).

  6. Intrinsic rotation in DIII-D

    SciTech Connect

    DeGrassie, J. S.; Rice, J. E.; Burrell, K. H.; Groebner, R. J.; Solomon, W. M.

    2007-05-15

    In the absence of any auxiliary torque input, the DIII-D plasma consists of nonzero toroidal angular momentum, in other words, it rotates. This effect is commonly observed in tokamaks, being referred to as intrinsic rotation. Measurements of intrinsic rotation profiles have been made in DIII-D [J. Luxon, Nucl. Fusion 42, 614 (2002)] H-mode discharges, with both Ohmic heating (OH) and electron cyclotron heating (ECH) in which there is no auxiliary torque. Recently, the H-mode data set has been extended with the newly configured DIII-D simultaneous co- and counter-directed neutral beam injection (NBI) capability resulting in control of the local torque deposition, where co and counter refer to the direction relative to the toroidal plasma current. Understanding intrinsic rotation is important for projection toward burning plasma performance where any NBI torque will be relatively small. The toroidal velocity is recognizably important regarding issues of stability and confinement. In DIII-D ECH H-modes the rotation profile is hollow, co-directed at large minor radius and depressed, or actually counter-directed, nearer the magnetic axis. This profile varies with the ECH power deposition profile to some extent. In contrast, OH H-modes have a relatively flat co-directed rotation profile. There is a scaling of the DIII-D intrinsic toroidal velocity with W/I{sub p}, as seen in intrinsic rotation in Alcator C-Mod [J. Rice, Nucl. Fusion 39, 1175 (1999)], where W is the total plasma thermal energy and I{sub p} is the magnitude of the toroidal plasma current. This common scaling resulted in a dimensionless similarity experiment between DIII-D and Alcator C-Mod on intrinsic rotation, obtaining a single spatial point match in the toroidal velocity normalized to the ion thermal velocity. The balanced NBI capability in DIII-D is a useful tool to push scaling studies to higher values of the plasma normalized energy, notwithstanding the details of torque deposition for co-NBI versus

  7. The intrinsic heterogeneity of superconductivity in the cuprates

    NASA Astrophysics Data System (ADS)

    Shengelaya, A.; Müller, K. A.

    2015-01-01

    In the hole-doped, high-temperature superconducting cuprates, an intrinsic heterogeneity is found, from the early observations to recent data. Below optimum doping, the heterogeneity consists of dynamic metallic and, at low temperatures, superconducting regions in the form of clusters or stripes, which develop and decay as a function of time and location in the antiferromagnetic lattice. This behaviour is underlined by the interesting linear relation between the oxygen isotope shifts of the magnetic penetration depth and the critical temperature with a slope that is a factor 2 larger than expected for the homogeneous distribution of superfluid density. Allusion is also made to the Bose-Einstein condensation reported in structurally heterogeneous, polycrystalline polymer platelets as well as especially to the heterogeneous distribution of visible and dark matter in the Universe, which point to a change of paradigm in modern physics.

  8. Intrinsic mode functions locate implicit turbulent attractors in time in frontal lobe MEG recordings.

    PubMed

    Huang, X; Huang, L; Jung, T-P; Cheng, C-K; Mandell, A J

    2014-05-16

    In seeking evidence for the presence and characteristic range of coupled time scale(s) of putative implicit turbulent attractors of dorsal frontal lobe magnetic fields, the recorded nonstationary, nonlinear MEG signals were non-orthogonally decomposed using Huang's Empirical Mode Decomposition, EMD, (Huang and Attoh-Okine, 2005) into 16 Intrinsic Mode Functions, EMD→IMFi, i=1…16. Measures known to be invariant in non-uniformly hyperbolic (turbulent) dynamical systems, topological entropy, hT, metric entropy, hM, non-uniform entropy, hU and power spectral scaling exponent, α, were imposed on each of the IMFi which evidenced most clearly an invariant temporal scale zone of IMFi, i=6…11, for hT, which we have found to be the most robust of invariant measures of MEG's magnetic field turbulent attractors (Mandell et al., 2011a,b; Mandell, 2013). The ergodic theory of dynamical systems (Walters, 1982; Pollicott and Yuri, 1998) allows the inference that an implicit attractor with consistently hT>0 will also evidence at least one positive Lyapounov exponent indicating the presence of a turbulent attractor with exponential separation of nearby initial conditions, exponential convergence of distant points and disordering, mixing, of orbital sequences. It appears that this approach permits the inference of the presence of chaotic, turbulent attractor and its characteristic time scales without the invocation of arbitrary n-dimensional embedding, phase space reconstructions or (inappropriate) orthogonal decompositions.

  9. Direct measurement of intrinsic atomic scale magnetostriction.

    PubMed

    Ruffoni, M P; Pascarelli, S; Grössinger, R; Turtelli, R Sato; Bormio-Nunes, C; Pettifer, R F

    2008-10-03

    Using differential x-ray absorption spectroscopy (DiffXAS) we have measured and quantified the intrinsic, atomic-scale magnetostriction of Fe81Ga19. By exploiting the chemical selectivity of DiffXAS, the Fe and Ga local environments have been assessed individually. The enhanced magnetostriction induced by the addition of Ga to Fe was found to originate from the Ga environment, where lambda;{gamma,2}( approximately (3/2)lambda_{100}) is 390+/-40 ppm. In this environment, 001 Ga-Ga pair defects were found to exist, which mediate the magnetostriction by inducing large strains in the surrounding Ga-Fe bonds. For the first time, intrinsic, chemically selective magnetostrictive strain has been measured and quantified at the atomic level, allowing true comparison with theory.

  10. Intrinsic two-dimensional features as textons

    NASA Technical Reports Server (NTRS)

    Barth, E.; Zetzsche, C.; Rentschler, I.

    1998-01-01

    We suggest that intrinsic two-dimensional (i2D) features, computationally defined as the outputs of nonlinear operators that model the activity of end-stopped neurons, play a role in preattentive texture discrimination. We first show that for discriminable textures with identical power spectra the predictions of traditional models depend on the type of nonlinearity and fail for energy measures. We then argue that the concept of intrinsic dimensionality, and the existence of end-stopped neurons, can help us to understand the role of the nonlinearities. Furthermore, we show examples in which models without strong i2D selectivity fail to predict the correct ranking order of perceptual segregation. Our arguments regarding the importance of i2D features resemble the arguments of Julesz and co-workers regarding textons such as terminators and crossings. However, we provide a computational framework that identifies textons with the outputs of nonlinear operators that are selective to i2D features.

  11. Cell-intrinsic drivers of dendrite morphogenesis.

    PubMed

    Puram, Sidharth V; Bonni, Azad

    2013-12-01

    The proper formation and morphogenesis of dendrites is fundamental to the establishment of neural circuits in the brain. Following cell cycle exit and migration, neurons undergo organized stages of dendrite morphogenesis, which include dendritic arbor growth and elaboration followed by retraction and pruning. Although these developmental stages were characterized over a century ago, molecular regulators of dendrite morphogenesis have only recently been defined. In particular, studies in Drosophila and mammalian neurons have identified numerous cell-intrinsic drivers of dendrite morphogenesis that include transcriptional regulators, cytoskeletal and motor proteins, secretory and endocytic pathways, cell cycle-regulated ubiquitin ligases, and components of other signaling cascades. Here, we review cell-intrinsic drivers of dendrite patterning and discuss how the characterization of such crucial regulators advances our understanding of normal brain development and pathogenesis of diverse cognitive disorders.

  12. The Intrinsic Shape of Galaxy Bulges

    NASA Astrophysics Data System (ADS)

    Méndez-Abreu, Jairo

    The knowledge of the intrinsic three-dimensional (3D) structure of galaxy components provides crucial information about the physical processes driving their formation and evolution. In this paper I discuss the main developments and results in the quest to better understand the 3D shape of galaxy bulges. I start by establishing the basic geometrical description of the problem. Our understanding of the intrinsic shape of elliptical galaxies and galaxy discs is then presented in a historical context, in order to place the role that the 3D structure of bulges play in the broader picture of galaxy evolution. Our current view on the 3D shape of the Milky Way bulge and future prospects in the field are also depicted.

  13. Intrinsic emittance reduction in transmission mode photocathodes

    NASA Astrophysics Data System (ADS)

    Lee, Hyeri; Cultrera, Luca; Bazarov, Ivan

    2016-03-01

    High quantum efficiency (QE) and low emittance electron beams provided by multi-alkali photocathodes make them of great interest for next generation high brightness photoinjectors. Spicer's three-step model well describes the photoemission process; however, some photocathode characteristics such as their thickness have not yet been completely exploited to further improve the brightness of the generated electron beams. In this work, we report on the emittance and QE of a multi-alkali photocathode grown onto a glass substrate operated in transmission and reflection modes at different photon energies. We observed a 20% reduction in the intrinsic emittance from the reflection to the transmission mode operation. This observation can be explained by inelastic electron-phonon scattering during electrons' transit towards the cathode surface. Due to this effect, we predict that thicker photocathode layers will further reduce the intrinsic emittance of electron beams generated by photocathodes operated in transmission mode.

  14. Intrinsically Radiolabeled Nanoparticles: An Emerging Paradigm

    PubMed Central

    Goel, Shreya; Ehlerding, Emily B.

    2014-01-01

    Although chelator-based radiolabeling techniques have been used for decades, concerns about the complexity of coordination chemistry, possible altering of pharmacokinetics of carriers, and potential detachment of radioisotopes during imaging have driven the need for developing a simple yet better technique for future radiolabeling. Here, the emerging concept of intrinsically radiolabeled nanoparticles, which could be synthesized using methods such as hot-plus-cold precursors, specific trapping, cation exchange, and proton beam activation, is introduced. Representative examples of using these multifunctional nanoparticles for multimodality molecular imaging are highlighted together with current challenges and future research directions. Although still in the early stages, design and synthesis of intrinsically radiolabeled nanoparticles has shown attractive potential to offer easier, faster, and more specific radiolabeling possibilities for the next generation of molecular imaging. PMID:24978934

  15. Intrinsic excitations in doubly odd nuclei

    SciTech Connect

    Sood, P.C.

    1985-01-15

    A procedure is outlined for predicting the bandhead energies of the two-particle (intrinsic) states of odd-odd deformed nuclei based on a quantitative evaluation of the zero range n-p residual interaction energy. We present our results for 250Bk, where many such levels are experimentally known, and for 236Np and 246Am, where the information is very scarce and that too uncertain, to illustrate the effectiveness of this approach.

  16. Intrinsic interfacial phenomena in manganite heterostructures.

    PubMed

    Vaz, C A F; Walker, F J; Ahn, C H; Ismail-Beigi, S

    2015-04-01

    We review recent advances in our understanding of interfacial phenomena that emerge when dissimilar materials are brought together at atomically sharp and coherent interfaces. In particular, we focus on phenomena that are intrinsic to the interface and review recent work carried out on perovskite manganites interfaces, a class of complex oxides whose rich electronic properties have proven to be a useful playground for the discovery and prediction of novel phenomena.

  17. Design Space Issues for Intrinsic Evolvable Hardware

    NASA Technical Reports Server (NTRS)

    Hereford, James; Gwaltney, David

    2004-01-01

    This paper discusses the problem of increased programming time for intrinsic evolvable hardware (EM) as the complexity of the circuit grows. As the circuit becomes more complex, then more components will be required and a longer programming string, L, is required. We develop equations for the size of the population, n, and the number of generations required for the population to converge, based on L. Our analytical results show that even though the design search space grows as 2L (assuming a binary programming string), the number of circuit evaluations, n*ngen, only grows as O(Lg3), or slightly less than O(L). This makes evolvable techniques a good tool for exploring large design spaces. The major hurdle for intrinsic EHW is evaluation time for each possible circuit. The evaluation time involves downloading the bit string to the device, updating the device configuration, measuring the output and then transferring the output data to the control processor. Each of these steps must be done for each member of the population. The processing time of the computer becomes negligible since the selection/crossover/mutation steps are only done once per generation. Evaluation time presently limits intrinsic evolvable hardware techniques to designing only small or medium-sized circuits. To evolve large or complicated circuits, several researchers have proposed using hierarchical design or reuse techniques where submodules are combined together to form complex circuits. However, these practical approaches limit the search space of available designs and preclude utilizing parasitic coupling or other effects within the programmable device. The practical approaches also raise the issue of why intrinsic EHW techniques do not easily apply to large design spaces, since the analytical results show only an O(L) complexity growth.

  18. Intrinsic spin dynamics in semiconductor quantum dots

    NASA Astrophysics Data System (ADS)

    Valín-Rodríguez, Manuel

    2005-12-01

    We investigate the characteristic spin dynamics corresponding to semiconductor quantum dots within the multiband envelope function approximation (EFA). By numerically solving an 8 × 8 k·p Hamiltonian we treat systems based on different III-V semiconductor materials. It is shown that, even in the absence of an applied magnetic field, these systems show intrinsic spin dynamics governed by intraband and interband transitions leading to characteristic spin frequencies ranging from THz to optical frequencies.

  19. Correlation between Intrinsic Patellofemoral Pain Syndrome in Young Adults and Lower Extremity Biomechanics.

    PubMed

    Kwon, Ohjeoung; Yun, Mijung; Lee, Wanhee

    2014-07-01

    [Purpose] The purpose of this study was to evaluate the correlation between intrinsic patellofemoral pain syndrome (PFPS) in young adults and lower extremity biomechanics. [Subjects] This experiment was carried out with sixty (24 men and 32 women), who are normal university students as subjects. [Methods] All subjects underwent 3 clinical evaluations. For distinguishing the intrinsic PFPS from controls, we used the Modified Functional Index Questionnaire (MFIQ), Clarke's test and the Eccentric step test. Based on the results of the tests, subjects who were classified as positive for 2 more tests were allocated to the bilateral or unilateral intrinsic PFPS group (n=14), and the others were allocated to the control group (n=42). These two groups were tested for hamstring tightness, foot overpronation, and static Q-angle and dynamic Q-angle. These are the four lower extremity biomechanic, cited as risk factors of patellofemoral pain syndrome. [Results] The over pronation, static Q-angle and the dynamic Q-angle were not significantly different between the two groups. However, the hamstring tightness of the PFPS group was significantly greater than that of the controls. [Conclusion] We examined individuals for intrinsic patellofemoral pain syndrome in young adults and lower extremity biomechanics. We found a strong correlation between intrinsic PFPS and hamstring tightness.

  20. Inhibitory control of intrinsic hippocampal oscillations?

    PubMed

    Fischer, Yacov; Dürr, Roland

    2003-08-22

    An oscillatory mode of activity is a basic operational mode of the hippocampus. Such activity involves the concurrent expression of several rhythmic processes, of which theta (4-15 Hz) and gamma (20-80 Hz) oscillations are prominent and considered to be important for cognitive processing. In an experimental model that preserves the intrinsic network oscillator, exhibiting the dependency on cholinergic inputs and consequent expression of concurrent theta and gamma oscillations, we investigate the intrinsic mechanisms underlying such integrated hippocampal network responses. This experimental framework is used here to examine the currently prevailing dogma, that interneurons control hippocampal oscillations. The spontaneous response of individual pyramidal cells (in areas CA3 and CA1) and interneurons (area CA3), during oscillatory activity, was monitored intracellularly. Particular attention was given to the initiation of interneuron discharge during oscillations, to the impact of the synaptic output of discharging interneurons on the oscillatory activity, and to the time at which interneurons discharge in relation to the oscillatory cycles. Analysis of the spontaneous patterns of activity in individual interneurons and their outcome, during the oscillatory activity, revealed that interneuron activity is incompatible with initiating, pacing or determining the oscillatory frequencies, although contributing to the apparent rhythmic patterns. Moreover, our results show that non-interneuronal members of the network control interneuron activity. We therefore suggest that the activity of the excitatory cells, i.e., principle cells, is critical toward the initiation, pacing and synchronization of intrinsic hippocampal network oscillations.

  1. Moral Distress, Workplace Health, and Intrinsic Harm.

    PubMed

    Weber, Elijah

    2016-05-01

    Moral distress is now being recognized as a frequent experience for many health care providers, and there's good evidence that it has a negative impact on the health care work environment. However, contemporary discussions of moral distress have several problems. First, they tend to rely on inadequate characterizations of moral distress. As a result, subsequent investigations regarding the frequency and consequences of moral distress often proceed without a clear understanding of the phenomenon being discussed, and thereby risk substantially misrepresenting the nature, frequency, and possible consequences of moral distress. These discussions also minimize the intrinsically harmful aspects of moral distress. This is a serious omission. Moral distress doesn't just have a negative impact on the health care work environment; it also directly harms the one who experiences it. In this paper, I claim that these problems can be addressed by first clarifying our understanding of moral distress, and then identifying what makes moral distress intrinsically harmful. I begin by identifying three common mistakes that characterizations of moral distress tend to make, and explaining why these mistakes are problematic. Next, I offer an account of moral distress that avoids these mistakes. Then, I defend the claim that moral distress is intrinsically harmful to the subject who experiences it. I conclude by explaining how acknowledging this aspect of moral distress should reshape our discussions about how best to deal with this phenomenon.

  2. Solving the Riddle of the Incompatibility Between Renormalizability and Unitarity in N-Dimensional Einstein Gravity Enlarged by Curvature-Squared Terms

    NASA Astrophysics Data System (ADS)

    Accioly, Antonio; Helayël-Neto, José; Scatena, Eslley; Turcati, Rodrigo

    2013-09-01

    One of the puzzling aspects of N-dimensional Einstein Gravity (NDEG) augmented by curvature-squared terms is why renormalizability and unitarity, two of the most important properties of any physical theory, cannot be reconciled in its framework. Actually, the reason why these properties are mutually incompatible within the context of generic higher-derivative models, not necessarily related to gravity, is one of the unsolved mysteries of physics. Here, a simple solution to the NDEG riddle, based on the analysis of the interparticle gravitational potential, is presented. The main argument used to support our discussion is that tree-level unitarity and the existence of a singularity in the potential are intertwined.

  3. The Quantum Group as a Symmetry ---The Schrödinger Equation of the N-Dimensional q-Deformed Harmonic Oscillator---

    NASA Astrophysics Data System (ADS)

    Carow-Watamura, U.; Watamura, S.

    With the aim to construct a dynamical model with quantum group symmetry, the q-deformed Schrödinger equation of the harmonic oscillator on the N-dimensional quantum Euclidian space is investigated. After reviewing the differential calculus on the q-Euclidian space, the q-analog of the creation-annihilation operator is constructed. It is shown that it produces systematically all eigenfunctions of the Schrödinger equation and eigenvalues. We also present an alternative way to solve the Schrödinger equation which is based on the q-analysis. We represent the Schrödinger equation by the q-difference equation and solve it by using q-polynomials and q-exponential functions. The problem of the involution corresponding to the reality condition is discussed.

  4. Effects of Extrinsic Rewards on Intrinsic Motivation in the Classroom.

    ERIC Educational Resources Information Center

    Workman, Edward A.; Williams, Robert L.

    1980-01-01

    Reviews classroom behavior management studies to see if extrinsic rewards affect intrinsic reinforcement value of appropriate classroom behaviors. Conclusion indicates extrinsic rewards are useful. Teachers need not avoid the use of rewards in fear of undermining intrinsic interest. (LAB)

  5. Genetically Engineered Mouse Model of Diffuse Intrinsic Pontine Glioma as a Preclinical Tool

    DTIC Science & Technology

    2012-09-01

    CONTRACTING ORGANIZATION: Duke University REPORT DATE: TYPE OF REPORT: PREPARED FOR: U.S. Army Medical Research and Materiel...display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE 2. REPORT TYPE Annual 3. DATES...ABSTRACT Diffuse Intrinsic Pontine Gliomas or DIPG, is a type of brain tumor that afflicts children and is the leading cause of death in pediatric

  6. Fundamental Advances in Inverse Mechanics Towards Self-Aware and Intrinsically Adaptable Structural Systems

    DTIC Science & Technology

    2014-11-30

    AFRL-OSR-VA-TR-2015-0007 FUNDAMENTAL ADVANCES IN INVERSE MECHANICS TOWARDS SELF-AWARE JOHN BRIGHAM UNIVERSITY OF PITTSBURGH Final Report 12/04/2014...TITLE AND SUBTITLE Fundamental Advances in Inverse Mechanics Towards Self-Aware and Intrinsically Adaptable Structural Systems 5a. CONTRACT NUMBER...methods for solving inverse problems related to smart morphable structures that can evaluate their current environment and then adapt accordingly to

  7. Intrinsic Motivation: An Overlooked Component for Student Success

    ERIC Educational Resources Information Center

    Augustyniak, Robert A.; Ables, Adrienne Z.; Guilford, Philip; Lujan, Heidi L.; Cortright, Ronald N.; DiCarlo, Stephen E.

    2016-01-01

    Intrinsic motivation to learn involves engaging in learning opportunities because they are seen as enjoyable, interesting, or relevant to meeting one's core psychological needs. As a result, intrinsic motivation is associated with high levels of effort and task performance. Students with greater levels of intrinsic motivation demonstrate strong…

  8. Metacognitive mastery and intrinsic motivation in schizophrenia.

    PubMed

    Vohs, Jenifer L; Lysaker, Paul H

    2014-01-01

    Deficits in intrinsic motivation (IM) have been linked to poorer outcome in schizophrenia, but its proximal mechanisms remain poorly understood. This study examined whether metacognitive mastery, or the capacity to use knowledge of self, others, and context to identify and cope with psychological difficulties, predicted levels of IM for 6 months among 75 participants with prolonged schizophrenia. Repeated-measures analysis of variance revealed that high metacognitive mastery predicted consistently higher levels of IM; however, intermediate and low mastery did not produce unique IM profiles. The findings suggest that metacognitive mastery may have an important role in IM over time and could be a meaningful treatment target.

  9. Intrinsically disordered proteins and multicellular organisms.

    PubMed

    Dunker, A Keith; Bondos, Sarah E; Huang, Fei; Oldfield, Christopher J

    2015-01-01

    Intrinsically disordered proteins (IDPs) and IDP regions lack stable tertiary structure yet carry out numerous biological functions, especially those associated with signaling, transcription regulation, DNA condensation, cell division, and cellular differentiation. Both post-translational modifications (PTMs) and alternative splicing (AS) expand the functional repertoire of IDPs. Here we propose that an "IDP-based developmental toolkit," which is comprised of IDP regions, PTMs, especially multiple PTMs, within these IDP regions, and AS events within segments of pre-mRNA that code for these same IDP regions, allows functional diversification and environmental responsiveness for molecules that direct the development of complex metazoans.

  10. Thin film solar cell including a spatially modulated intrinsic layer

    DOEpatents

    Guha, Subhendu; Yang, Chi-Chung; Ovshinsky, Stanford R.

    1989-03-28

    One or more thin film solar cells in which the intrinsic layer of substantially amorphous semiconductor alloy material thereof includes at least a first band gap portion and a narrower band gap portion. The band gap of the intrinsic layer is spatially graded through a portion of the bulk thickness, said graded portion including a region removed from the intrinsic layer-dopant layer interfaces. The band gap of the intrinsic layer is always less than the band gap of the doped layers. The gradation of the intrinsic layer is effected such that the open circuit voltage and/or the fill factor of the one or plural solar cell structure is enhanced.

  11. MRI endoscopy using intrinsically localized probes

    PubMed Central

    Sathyanarayana, Shashank; Bottomley, Paul A.

    2009-01-01

    Magnetic resonance imaging (MRI) is traditionally performed with fixed externally applied gradient magnetic fields and is hence intrinsically locked to the laboratory frame of reference (FoR). Here a method for high-resolution MRI that employs active, catheter-based, tiny internal probes that utilize the spatial properties of the probe itself for localization is proposed and demonstrated at 3 T. Because these properties are intrinsic to the probe, they move with it, transforming MRI from the laboratory FoR to the FoR of the device itself, analogous to an endoscope. The “MRI endoscope” can utilize loop coils and loopless antennas with modified sensitivity, in combination with adiabatic excitation by the device itself, to restrict the MRI sensitivity to a disk-shaped plane a few mm thick. Excitation with the MRI endoscope limits the eddy currents induced in the sample to an excited volume whose size is orders of magnitude below that excited by a conventional body MRI coil. Heat testing shows maximum local temperature increases of <1 °C during MRI, within regulatory guidelines. The method is demonstrated in a kiwifruit, in intact porcine and rabbit aortas, and in an atherosclerotic human iliac artery specimen, with in-plane resolution as small as 80 μm and 1.5–5 mm slice thickness. PMID:19378751

  12. Intrinsic graph structure estimation using graph Laplacian.

    PubMed

    Noda, Atsushi; Hino, Hideitsu; Tatsuno, Masami; Akaho, Shotaro; Murata, Noboru

    2014-07-01

    A graph is a mathematical representation of a set of variables where some pairs of the variables are connected by edges. Common examples of graphs are railroads, the Internet, and neural networks. It is both theoretically and practically important to estimate the intensity of direct connections between variables. In this study, a problem of estimating the intrinsic graph structure from observed data is considered. The observed data in this study are a matrix with elements representing dependency between nodes in the graph. The dependency represents more than direct connections because it includes influences of various paths. For example, each element of the observed matrix represents a co-occurrence of events at two nodes or a correlation of variables corresponding to two nodes. In this setting, spurious correlations make the estimation of direct connection difficult. To alleviate this difficulty, a digraph Laplacian is used for characterizing a graph. A generative model of this observed matrix is proposed, and a parameter estimation algorithm for the model is also introduced. The notable advantage of the proposed method is its ability to deal with directed graphs, while conventional graph structure estimation methods such as covariance selections are applicable only to undirected graphs. The algorithm is experimentally shown to be able to identify the intrinsic graph structure.

  13. Rotating pigment cells exhibit an intrinsic chirality.

    PubMed

    Yamanaka, Hiroaki; Kondo, Shigeru

    2015-01-01

    In multicellular organisms, cell properties, such as shape, size and function are important in morphogenesis and physiological functions. Recently, 'cellular chirality' has attracted attention as a cellular property because it can cause asymmetry in the bodies of animals. In recent in vitro studies, the left-right bias of cellular migration and of autonomous arrangement of cells under some specific culture conditions were discovered. However, it is difficult to identify the molecular mechanism underlying their intrinsic chirality because the left-right bias observed to date is subtle or is manifested in the stable orientation of cells. Here, we report that zebrafish (Danio rerio) melanophores exhibit clear cellular chirality by unidirectional counterclockwise rotational movement under isolated conditions without any special settings. The chirality is intrinsic to melanophores because the direction of the cellular rotation was not affected by the type of extracellular matrix. We further found that the cellular rotation was generated as a counter action of the clockwise movement of actin cytoskeleton. It suggested that the mechanism that directs actin cytoskeleton in the clockwise direction is pivotal for determining cellular chirality.

  14. Intrinsically disordered proteins drive membrane curvature

    NASA Astrophysics Data System (ADS)

    Busch, David J.; Houser, Justin R.; Hayden, Carl C.; Sherman, Michael B.; Lafer, Eileen M.; Stachowiak, Jeanne C.

    2015-07-01

    Assembly of highly curved membrane structures is essential to cellular physiology. The prevailing view has been that proteins with curvature-promoting structural motifs, such as wedge-like amphipathic helices and crescent-shaped BAR domains, are required for bending membranes. Here we report that intrinsically disordered domains of the endocytic adaptor proteins, Epsin1 and AP180 are highly potent drivers of membrane curvature. This result is unexpected since intrinsically disordered domains lack a well-defined three-dimensional structure. However, in vitro measurements of membrane curvature and protein diffusivity demonstrate that the large hydrodynamic radii of these domains generate steric pressure that drives membrane bending. When disordered adaptor domains are expressed as transmembrane cargo in mammalian cells, they are excluded from clathrin-coated pits. We propose that a balance of steric pressure on the two surfaces of the membrane drives this exclusion. These results provide quantitative evidence for the influence of steric pressure on the content and assembly of curved cellular membrane structures.

  15. Intrinsic radiation resistance in human chondrosarcoma cells

    SciTech Connect

    Moussavi-Harami, Farid; Mollano, Anthony; Martin, James A.; Ayoob, Andrew; Domann, Frederick E.; Gitelis, Steven; Buckwalter, Joseph A. . E-mail: joseph-buckwalter@uiowa.edu

    2006-07-28

    Human chondrosarcomas rarely respond to radiation treatment, limiting the options for eradication of these tumors. The basis of radiation resistance in chondrosarcomas remains obscure. In normal cells radiation induces DNA damage that leads to growth arrest or death. However, cells that lack cell cycle control mechanisms needed for these responses show intrinsic radiation resistance. In previous work, we identified immortalized human chondrosarcoma cell lines that lacked p16{sup ink4a}, one of the major tumor suppressor proteins that regulate the cell cycle. We hypothesized that the absence of p16{sup ink4a} contributes to the intrinsic radiation resistance of chondrosarcomas and that restoring p16{sup ink4a} expression would increase their radiation sensitivity. To test this we determined the effects of ectopic p16{sup ink4a} expression on chondrosarcoma cell resistance to low-dose {gamma}-irradiation (1-5 Gy). p16{sup ink4a} expression significantly increased radiation sensitivity in clonogenic assays. Apoptosis did not increase significantly with radiation and was unaffected by p16{sup ink4a} transduction of chondrosarcoma cells, indicating that mitotic catastrophe, rather than programmed cell death, was the predominant radiation effect. These results support the hypothesis that p16{sup ink4a} plays a role in the radiation resistance of chondrosarcoma cell lines and suggests that restoring p16 expression will improve the radiation sensitivity of human chondrosarcomas.

  16. Intrinsically disordered proteins drive membrane curvature

    PubMed Central

    Busch, David J.; Houser, Justin R.; Hayden, Carl C.; Sherman, Michael B.; Lafer, Eileen M.; Stachowiak, Jeanne C.

    2015-01-01

    Assembly of highly curved membrane structures is essential to cellular physiology. The prevailing view has been that proteins with curvature-promoting structural motifs, such as wedge-like amphipathic helices and crescent-shaped BAR domains, are required for bending membranes. Here we report that intrinsically disordered domains of the endocytic adaptor proteins, Epsin1 and AP180 are highly potent drivers of membrane curvature. This result is unexpected since intrinsically disordered domains lack a well-defined three-dimensional structure. However, in vitro measurements of membrane curvature and protein diffusivity demonstrate that the large hydrodynamic radii of these domains generate steric pressure that drives membrane bending. When disordered adaptor domains are expressed as transmembrane cargo in mammalian cells, they are excluded from clathrin-coated pits. We propose that a balance of steric pressure on the two surfaces of the membrane drives this exclusion. These results provide quantitative evidence for the influence of steric pressure on the content and assembly of curved cellular membrane structures. PMID:26204806

  17. The Neglected Intrinsic Resistome of Bacterial Pathogens

    PubMed Central

    Fajardo, Alicia; Martínez-Martín, Nadia; Mercadillo, María; Galán, Juan C.; Ghysels, Bart; Matthijs, Sandra; Cornelis, Pierre; Wiehlmann, Lutz; Tümmler, Burkhard; Baquero, Fernando; Martínez, José L.

    2008-01-01

    Bacteria with intrinsic resistance to antibiotics are a worrisome health problem. It is widely believed that intrinsic antibiotic resistance of bacterial pathogens is mainly the consequence of cellular impermeability and activity of efflux pumps. However, the analysis of transposon-tagged Pseudomonas aeruginosa mutants presented in this article shows that this phenotype emerges from the action of numerous proteins from all functional categories. Mutations in some genes make P. aeruginosa more susceptible to antibiotics and thereby represent new targets. Mutations in other genes make P. aeruginosa more resistant and therefore define novel mechanisms for mutation-driven acquisition of antibiotic resistance, opening a new research field based in the prediction of resistance before it emerges in clinical environments. Antibiotics are not just weapons against bacterial competitors, but also natural signalling molecules. Our results demonstrate that antibiotic resistance genes are not merely protective shields and offer a more comprehensive view of the role of antibiotic resistance genes in the clinic and in nature. PMID:18286176

  18. Intrinsic adaptation in autonomous recurrent neural networks.

    PubMed

    Marković, Dimitrije; Gros, Claudius

    2012-02-01

    A massively recurrent neural network responds on one side to input stimuli and is autonomously active, on the other side, in the absence of sensory inputs. Stimuli and information processing depend crucially on the quality of the autonomous-state dynamics of the ongoing neural activity. This default neural activity may be dynamically structured in time and space, showing regular, synchronized, bursting, or chaotic activity patterns. We study the influence of nonsynaptic plasticity on the default dynamical state of recurrent neural networks. The nonsynaptic adaption considered acts on intrinsic neural parameters, such as the threshold and the gain, and is driven by the optimization of the information entropy. We observe, in the presence of the intrinsic adaptation processes, three distinct and globally attracting dynamical regimes: a regular synchronized, an overall chaotic, and an intermittent bursting regime. The intermittent bursting regime is characterized by intervals of regular flows, which are quite insensitive to external stimuli, interceded by chaotic bursts that respond sensitively to input signals. We discuss these findings in the context of self-organized information processing and critical brain dynamics.

  19. Intrinsically disordered proteins drive membrane curvature.

    PubMed

    Busch, David J; Houser, Justin R; Hayden, Carl C; Sherman, Michael B; Lafer, Eileen M; Stachowiak, Jeanne C

    2015-07-24

    Assembly of highly curved membrane structures is essential to cellular physiology. The prevailing view has been that proteins with curvature-promoting structural motifs, such as wedge-like amphipathic helices and crescent-shaped BAR domains, are required for bending membranes. Here we report that intrinsically disordered domains of the endocytic adaptor proteins, Epsin1 and AP180 are highly potent drivers of membrane curvature. This result is unexpected since intrinsically disordered domains lack a well-defined three-dimensional structure. However, in vitro measurements of membrane curvature and protein diffusivity demonstrate that the large hydrodynamic radii of these domains generate steric pressure that drives membrane bending. When disordered adaptor domains are expressed as transmembrane cargo in mammalian cells, they are excluded from clathrin-coated pits. We propose that a balance of steric pressure on the two surfaces of the membrane drives this exclusion. These results provide quantitative evidence for the influence of steric pressure on the content and assembly of curved cellular membrane structures.

  20. The Mediation Role of Intrinsic and Extrinsic Motivation in the Relationship between Creative Educational Environment and Metacognitive Self-Regulation

    ERIC Educational Resources Information Center

    Maralani, Farnaz Mehdipour

    2016-01-01

    This study investigated the mediation role of intrinsic and extrinsic motivation in the relationship between creative educational environment and metacognitive self-regulation. Participants were 300 girls, selected randomly from the girl hostel in university of Tehran. Participants completed Akoal's creative educational environment questionnaire,…

  1. Universal Usability

    NASA Astrophysics Data System (ADS)

    Horton, Sarah; Leventhal, Laura

    Universal usability of World Wide Web (Web) environments—that is, having 90% of households as successful users—requires universal access, usability, and universal design. Factors such as Web technology and user-centered design contribute to universal access and usability, but key to universal usability is a universal design methodology. Universal design principles for the Web follow from universal design principles for the built environment, and emphasize perceptibility, self-explanation, and tailorability for the user. Universally usable Web environments offer the benefit of expanded participation, as well as the unanticipated benefits that generally follow from innovative design initiatives. However, to achieve Web universal usability, Web designers need tools that facilitate the design of intuitive interfaces without sacrificing universal access.

  2. Intrinsic galaxy shapes and alignments - II. Modelling the intrinsic alignment contamination of weak lensing surveys

    NASA Astrophysics Data System (ADS)

    Joachimi, B.; Semboloni, E.; Hilbert, S.; Bett, P. E.; Hartlap, J.; Hoekstra, H.; Schneider, P.

    2013-11-01

    Intrinsic galaxy alignments constitute the major astrophysical systematic of forthcoming weak gravitational lensing surveys but also yield unique insights into galaxy formation and evolution. We build analytic models for the distribution of galaxy shapes based on halo properties extracted from the Millennium Simulation, differentiating between early- and late-type galaxies as well as central galaxies and satellites. The resulting ellipticity correlations are investigated for their physical properties and compared to a suite of current observations. The best-faring model is then used to predict the intrinsic alignment contamination of planned weak lensing surveys. We find that late-type galaxy models generally have weak intrinsic ellipticity correlations, marginally increasing towards smaller galaxy separation and higher redshift. The signal for early-type models at fixed halo mass strongly increases by three orders of magnitude over two decades in galaxy separation, and by one order of magnitude from z = 0 to z = 2. The intrinsic alignment strength also depends strongly on halo mass, but not on galaxy luminosity at fixed mass, or galaxy number density in the environment. We identify models that are in good agreement with all observational data, except that all models overpredict alignments of faint early-type galaxies. The best model yields an intrinsic alignment contamination of a Euclid-like survey between 0.5 and 10 per cent at z > 0.6 and on angular scales larger than a few arcminutes. Cutting 20 per cent of red foreground galaxies using observer-frame colours can suppress this contamination by up to a factor of 2.

  3. Intrinsic noise in systems with switching environments

    NASA Astrophysics Data System (ADS)

    Hufton, Peter G.; Lin, Yen Ting; Galla, Tobias; McKane, Alan J.

    2016-05-01

    We study individual-based dynamics in finite populations, subject to randomly switching environmental conditions. These are inspired by models in which genes transition between on and off states, regulating underlying protein dynamics. Similarly, switches between environmental states are relevant in bacterial populations and in models of epidemic spread. Existing piecewise-deterministic Markov process approaches focus on the deterministic limit of the population dynamics while retaining the randomness of the switching. Here we go beyond this approximation and explicitly include effects of intrinsic stochasticity at the level of the linear-noise approximation. Specifically, we derive the stationary distributions of a number of model systems, in good agreement with simulations. This improves existing approaches which are limited to the regimes of fast and slow switching.

  4. Intrinsic Peroxidase-like Activity of Ficin

    PubMed Central

    Yang, Yufang; Shen, Dongjun; Long, Yijuan; Xie, Zhixiong; Zheng, Huzhi

    2017-01-01

    Ficin is classified as a sulfhydryl protease isolated from the latex of fig trees. In most cases, a particular enzyme fits a few types of substrate and catalyzes one type of reaction. In this investigation, we found sufficient proofs for the intrinsic peroxidase-like activity of ficin and designed experiments to examine its effectiveness in a variety of scenarios. Ficin can transform peroxidase substrates to colored products in the existence of H2O2. Our results also indicate that the active sites of peroxidase-like activity of ficin are different from that of protease, which reveals that one enzyme may catalyze more than one kind of substrate to perform different types of reactions. On the basis of these findings, H2O2 releasing from MCF-7 cells was detected successfully. Our findings support a wider application of ficin in biochemistry and open up the possibility of utilizing ficin as enzymatic mimics in biotechnology and environmental monitoring. PMID:28224979

  5. Intrinsic DX Centers in Ternary Chalcopyrite Semiconductors

    SciTech Connect

    Lany, S.; Zunger, A.

    2008-01-01

    In III-V and II-VI semiconductors, certain nominally electron-donating impurities do not release electrons but instead form deep electron-traps known as 'DX centers.' While in these compounds, such traps occur only after the introduction of foreign impurity atoms, we find from first-principles calculations that in ternary I-III-VI{sub 2} chalcopyrites like CuInSe{sub 2} and CuGaSe{sub 2}, DX-like centers can develop without the presence of any extrinsic impurities. These intrinsic DX centers are suggested as a cause of the difficulties to maintain high efficiencies in CuInSe{sub 2}-based thin-film solar-cells when the band gap is increased by addition of Ga.

  6. Measuring Intrinsic Curvature of Space with Electromagnetism

    NASA Astrophysics Data System (ADS)

    Mabin, Mason; Becker, Maria; Batelaan, Herman

    2016-10-01

    The concept of curved space is not readily observable in everyday life. The educational movie "Sphereland" attempts to illuminate the idea. The main character, a hexagon, has to go to great lengths to prove that her world is in fact curved. We present an experiment that demonstrates a new way to determine if a two-dimensional surface, the 2-sphere, is curved. The behavior of an electric field, placed on a spherical surface, is shown to be related to the intrinsic Gaussian curvature. This approach allows students to gain some understanding of Einstein's theory of general relativity, which relates the curvature of spacetime to the presence of mass and energy. Additionally, an opportunity is provided to investigate the dimensionality of Gauss's law.

  7. Tropical cyclone recurvature: An intrinsic property?

    NASA Astrophysics Data System (ADS)

    Chan, Kelvin T. F.; Chan, Johnny C. L.

    2016-08-01

    The typical track of a tropical cyclone (TC) in the Northern Hemisphere is an initial northwestward movement followed by an eventual turning toward the east. Such turning is referred to as recurvature and often explained by the change of the environmental flow that steers the TC. Here we show that even in the absence of background flow, a TC initiated at a high enough latitude can recurve itself. Differential horizontal advection of the planetary vorticity by the TC circulation at different vertical levels leads to the development of vertical wind shear, upper tropospheric anticyclone, and asymmetric distribution of convection. The flow associated with the upper tropospheric anticyclone on the equatorward side of the TC and the diabatic heating associated with the asymmetric convection combine to cause the TC to recurve. Such knowledge, an intrinsic recurvature property of the TC is important in forecasting the TC track when the environmental flow is weak.

  8. Unraveling the intrinsic color of chlorophyll.

    PubMed

    Milne, Bruce F; Toker, Yoni; Rubio, Angel; Nielsen, Steen Brøndsted

    2015-02-09

    The exact color of light absorbed by chlorophyll (Chl) pigments, the light-harvesters in photosynthesis, is tuned by the protein microenvironment, but without knowledge of the intrinsic color of Chl it remains unclear how large this effect is. Experimental first absorption energies of Chl a and b isolated in vacuo and tagged with quaternary ammonium cations are reported. The energies are largely insensitive to details of the tag structure, a finding supported by first-principles calculations using time-dependent density functional theory. Absorption is significantly blue-shifted compared to that of Chl-containing proteins (by 30-70 nm). A single red-shifting perturbation, such as axial ligation or the protein medium, is insufficient to account even for the smallest shift; the largest requires pigment-pigment interactions.

  9. Impact of Baryonic Physics on Intrinsic Alignments

    NASA Astrophysics Data System (ADS)

    Tenneti, Ananth; Gnedin, Nickolay Y.; Feng, Yu

    2017-01-01

    We explore the effects of specific assumptions in the subgrid models of star formation and stellar and active galactic nucleus feedback on intrinsic alignments of galaxies in cosmological simulations of the “MassiveBlack-II” family. Using smaller-volume simulations, we explore the parameter space of the subgrid star formation and feedback model and find remarkable robustness of the observable statistical measures to the details of subgrid physics. The one observational probe most sensitive to modeling details is the distribution of misalignment angles. We hypothesize that the amount of angular momentum carried away by the galactic wind is the primary physical quantity that controls the orientation of the stellar distribution. Our results are also consistent with a similar study by the EAGLE simulation team.

  10. Intrinsic Noise in Game Dynamical Learning

    NASA Astrophysics Data System (ADS)

    Galla, Tobias

    2009-11-01

    Demographic noise has profound effects on evolutionary and population dynamics, as well as on chemical reaction systems and models of epidemiology. Such noise is intrinsic and due to the discreteness of the dynamics in finite populations. We here show that similar noise-sustained trajectories arise in game dynamical learning, where the stochasticity has a different origin: agents sample a finite number of moves of their opponents in between adaptation events. The limit of infinite batches results in deterministic modified replicator equations, whereas finite sampling leads to a stochastic dynamics. The characteristics of these fluctuations can be computed analytically using methods from statistical physics, and such noise can affect the attractors significantly, leading to noise-sustained cycling or removing periodic orbits of the standard replicator dynamics.

  11. Helical Microfilaments with Alternating Imprinted Intrinsic Curvatures.

    PubMed

    Silva, Pedro Emanuel Santos; Godinho, Maria Helena

    2017-03-01

    There has been an intense research for developing techniques that can produce filaments with helical shapes, given the widespread of potential applications. In this work, how helices with different curvatures can be precisely imprinted in microfilaments is shown. It is also shown that using this technique, it is possible to produce, in a single fiber, helices with different curvatures. This striking and innovative behavior is observed when one side of the stretched filaments is irradiated with UV light, modifying the mechanical properties at surface. Upon release, the regions with higher curvature start to curl first, while regions with lower intrinsic curvature remain stretched until start to curl later. The results presented here can be important to understand why structures adopt a helical shape in general, which can be of interest in nanotechnology, biomolecular science, or even to understand why plant filaments curl.

  12. Nanotechnology Applications for Diffuse Intrinsic Pontine Glioma.

    PubMed

    Bredlau, Amy Lee; Dixit, Suraj; Chen, Chao; Broome, Ann-Marie

    2017-01-01

    Diffuse intrinsic pontine gliomas (DIPGs) are invariably fatal tumors found in the pons of elementary school aged children. These tumors are grade II-IV gliomas, with a median survival of less than 1 year from diagnosis when treated with standard of care (SOC) therapy. Nanotechnology may offer therapeutic options for the treatment of DIPGs. Multiple nanoparticle formulations are currently being investigated for the treatment of DIPGs. Nanoparticles based upon stable elements, polymer nanoparticles, and organic nanoparticles are under development for the treatment of brain tumors, including DIPGs. Targeting of nanoparticles is now possible as delivery techniques that address the difficulty in crossing the blood brain barrier (BBB) are developed. Theranostic nanoparticles, a combination of therapeutics and diagnostic nanoparticles, improve imaging of the cancerous tissue while delivering therapy to the local region. However, additional time and attention should be directed to developing a nanoparticle delivery system for treatment of the uniformly fatal pediatric disease of DIPG.

  13. Intrinsic Peroxidase-like Activity of Ficin

    NASA Astrophysics Data System (ADS)

    Yang, Yufang; Shen, Dongjun; Long, Yijuan; Xie, Zhixiong; Zheng, Huzhi

    2017-02-01

    Ficin is classified as a sulfhydryl protease isolated from the latex of fig trees. In most cases, a particular enzyme fits a few types of substrate and catalyzes one type of reaction. In this investigation, we found sufficient proofs for the intrinsic peroxidase-like activity of ficin and designed experiments to examine its effectiveness in a variety of scenarios. Ficin can transform peroxidase substrates to colored products in the existence of H2O2. Our results also indicate that the active sites of peroxidase-like activity of ficin are different from that of protease, which reveals that one enzyme may catalyze more than one kind of substrate to perform different types of reactions. On the basis of these findings, H2O2 releasing from MCF-7 cells was detected successfully. Our findings support a wider application of ficin in biochemistry and open up the possibility of utilizing ficin as enzymatic mimics in biotechnology and environmental monitoring.

  14. Intrinsic-surface-tag image authentication

    SciTech Connect

    Palm, R.G.; DeVolpi, A.

    1991-12-01

    The objective of this work is to further the development of a unique treaty limited item (TLI) intrinsic surface tag for arms control applications. This tag's unique feature is the ability to capture the sub-micron scale topography of the TLI surface. The surface topography is captured by plastic castings of the surface as digitally imaged by an electron microscope. Tag authentication is accomplished by comparing digital castings images obtained in two different inspections. Surface replication experiments are described, as these experiments from the basis for the authentication algorithm. Both the experiments and the authentication algorithm are analyzed using the modulation transfer function. Recommendations for future improvements in tag authentication are also suggested by the modulation transfer function analysis. 4 refs.

  15. Intrinsic-surface-tag image authentication

    SciTech Connect

    Palm, R.G.; DeVolpi, A.

    1991-12-01

    The objective of this work is to further the development of a unique treaty limited item (TLI) intrinsic surface tag for arms control applications. This tag`s unique feature is the ability to capture the sub-micron scale topography of the TLI surface. The surface topography is captured by plastic castings of the surface as digitally imaged by an electron microscope. Tag authentication is accomplished by comparing digital castings images obtained in two different inspections. Surface replication experiments are described, as these experiments from the basis for the authentication algorithm. Both the experiments and the authentication algorithm are analyzed using the modulation transfer function. Recommendations for future improvements in tag authentication are also suggested by the modulation transfer function analysis. 4 refs.

  16. Bifid Shape Is Intrinsic to Bifidobacterium adolescentis

    PubMed Central

    Dhanashree; Rajashekharan, Sharika; Krishnaswamy, Balamurugan; Kammara, Rajagopal

    2017-01-01

    Although the genus Bifidobacterium was originally named for its bifid morphology, not all bifidobacterial species have a similar structure, and very few of them adopt a bifid shape under stress conditions. The exposure of respective bifidobacterial species to various conditions, such as different pH, temperatures, medium components, in vivo growth in Caenorhabditis elegans, and subculture, did not affect their diverse morphologies. Extensive scanning electron microscopy studies suggested that the bifid shape of B. adolescentis are maintained irrespective of the conditions. Hence, we conclude that the bifid morphology is intrinsic to B. adolescentis. Most bifidobacterial species are anaerobic and rod-shaped, whereas, after the first generation, they become microaerophilic or aerophilic. CaCl2 (treatment of B. animalis) signaling triggered a change from the rod shape to the bifid shape and vice versa in B. adolescentis. PMID:28377762

  17. Intrinsic superstatistical components of financial time series

    NASA Astrophysics Data System (ADS)

    Vamoş, Călin; Crăciun, Maria

    2014-12-01

    Time series generated by a complex hierarchical system exhibit various types of dynamics at different time scales. A financial time series is an example of such a multiscale structure with time scales ranging from minutes to several years. In this paper we decompose the volatility of financial indices into five intrinsic components and we show that it has a heterogeneous scale structure. The small-scale components have a stochastic nature and they are independent 99% of the time, becoming synchronized during financial crashes and enhancing the heavy tails of the volatility distribution. The deterministic behavior of the large-scale components is related to the nonstationarity of the financial markets evolution. Our decomposition of the financial volatility is a superstatistical model more complex than those usually limited to a superposition of two independent statistics at well-separated time scales.

  18. Optical coherence tractography using intrinsic contrast

    PubMed Central

    Goergen, Craig J.; Radhakrishnan, Harsha; Sakadžić, Sava; Mandeville, Emiri T.; Lo, Eng H.; Sosnovik, David E.; Srinivasan, Vivek J.

    2013-01-01

    Organs such as the heart and brain possess intricate fiber structures that are best characterized with threedimensional imaging. For instance, diffusion-based, magnetic resonance tractography (MRT) enables studies of connectivity and remodeling during development and disease macroscopically on the millimeter scale. Here we present complementary, high-resolution microscopic optical coherence imaging and analysis methods that, when used in conjunction with clearing techniques, can characterize fiber architecture in intact organs at tissue depths exceeding 1 mm. We anticipate that these techniques can be used to study fiber architecture in situ at microscopic scales not currently accessible to diffusion magentic resonance (MR), and thus, to validate and complement macroscopic structural imaging techniques. Moreover, as these techniques use intrinsic signals and do not require tissue slicing and staining, they can be used for high-throughput, nondestructive evaluation of fiber architecture across large tissue volumes. PMID:23041891

  19. Impact of Baryonic Physics on Intrinsic Alignments

    SciTech Connect

    Tenneti, Ananth; Gnedin, Nickolay Y.; Feng, Yu

    2016-07-24

    We explore the effects of specific assumptions in the subgrid models of star formation and stellar and AGN feedback on intrinsic alignments of galaxies in cosmological simulations of "MassiveBlack-II" family. Using smaller volume simulations, we explored the parameter space of the subgrid star formation and feedback model and found remarkable robustness of the observable statistical measures to the details of subgrid physics. The one observational probe most sensitive to modeling details is the distribution of misalignment angles. We hypothesize that the amount of angular momentum carried away by the galactic wind is the primary physical quantity that controls the orientation of the stellar distribution. Our results are also consistent with a similar study by the EAGLE simulation team.

  20. Diverse precerebellar neurons share similar intrinsic excitability

    PubMed Central

    Kolkman, Kristine E.; McElvain, Lauren E.; du Lac, Sascha

    2011-01-01

    The cerebellum dedicates a majority of the brain’s neurons to processing a wide range of sensory, motor, and cognitive signals. Stereotyped circuitry within the cerebellar cortex suggests that similar computations are performed throughout the cerebellum, but little is known about whether diverse precerebellar neurons are specialized for the nature of the information they convey. In vivo recordings indicate that firing responses to sensory or motor stimuli vary dramatically across different precerebellar nuclei, but whether this reflects diverse synaptic inputs or differentially tuned intrinsic excitability has not been determined. We targeted whole-cell patch clamp recordings to neurons in 8 precerebellar nuclei which were retrogradely labeled from different regions of the cerebellum in mice. Intrinsic physiology was compared across neurons in the medial vestibular, external cuneate, lateral reticular, prepositus hypoglossi, supragenual, Roller/intercalatus, reticularis tegmenti pontis (NRTP), and pontine nuclei. Within the firing domain, precerebellar neurons were remarkably similar. Firing faithfully followed temporally modulated inputs, could be sustained at high rates, and was a linear function of input current over a wide range of inputs and firing rates. Pharmacological analyses revealed common expression of Kv3 currents, which were essential for a wide linear firing range, and of SK currents, which were essential for a wide linear input range. In contrast, membrane properties below spike threshold varied considerably within and across precerebellar nuclei, as evidenced by variability in postinhibitory rebound firing. Our findings indicate that diverse precerebellar neurons perfom similar scaling computations on their inputs but may be differentially tuned to synaptic inhibition. PMID:22090493

  1. Intrinsic radioactivity of KSr2I5:Eu2+

    NASA Astrophysics Data System (ADS)

    Rust, M.; Melcher, C.; Lukosi, E.

    2016-10-01

    A current need in nuclear security is an economical, yet high energy resolution (near 2%), scintillation detector suitable for gamma-ray spectroscopy. For current scintillators on the market, there is an inverse relationship between scintillator energy resolution and cost of production. A new promising scintillator, KSr2I5:Eu2+, under development at the University of Tennessee, has achieved an energy resolution of 2.4% at 662 keV at room temperature, with potential growth rates exceeding several millimeters per hour. However, the internal background due to the 40K content could present a hurdle for effective source detection/identification in nuclear security applications. As a first step in addressing this question, this paper reports on a computational investigation of the intrinsic differential pulse height spectrum (DPHS) generated by 40K within the KSr2I5:Eu2+ scintillator as a function of crystal geometry. It was found that the DPHS remains relatively equal to a constant multiplicative factor of the negatron emission spectrum with a direct increase of the 1.46 MeV photopeak relative height to the negatron spectrum with volume. Further, peak pileup does not readily manifest itself for practical KSr2I5:Eu2+ volumes.

  2. Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma.

    PubMed

    Taylor, Kathryn R; Mackay, Alan; Truffaux, Nathalène; Butterfield, Yaron S; Morozova, Olena; Philippe, Cathy; Castel, David; Grasso, Catherine S; Vinci, Maria; Carvalho, Diana; Carcaboso, Angel M; de Torres, Carmen; Cruz, Ofelia; Mora, Jaume; Entz-Werle, Natacha; Ingram, Wendy J; Monje, Michelle; Hargrave, Darren; Bullock, Alex N; Puget, Stéphanie; Yip, Stephen; Jones, Chris; Grill, Jacques

    2014-05-01

    Diffuse intrinsic pontine gliomas (DIPGs) are highly infiltrative malignant glial neoplasms of the ventral pons that, due to their location within the brain, are unsuitable for surgical resection and consequently have a universally dismal clinical outcome. The median survival time is 9-12 months, with neither chemotherapeutic nor targeted agents showing substantial survival benefit in clinical trials in children with these tumors. We report the identification of recurrent activating mutations in the ACVR1 gene, which encodes a type I activin receptor serine/threonine kinase, in 21% of DIPG samples. Strikingly, these somatic mutations (encoding p.Arg206His, p.Arg258Gly, p.Gly328Glu, p.Gly328Val, p.Gly328Trp and p.Gly356Asp substitutions) have not been reported previously in cancer but are identical to mutations found in the germ line of individuals with the congenital childhood developmental disorder fibrodysplasia ossificans progressiva (FOP) and have been shown to constitutively activate the BMP-TGF-β signaling pathway. These mutations represent new targets for therapeutic intervention in this otherwise incurable disease.

  3. Proximity to Intrinsic Depolarizing Resonances with a Partial Siberian Snake

    NASA Astrophysics Data System (ADS)

    Crandell, D. A.; Alexeeva, L. V.; Anferov, V. A.; Blinov, B. B.; Chu, C. M.; Caussyn, D. D.; Courant, E. D.; Gladycheva, S. E.; Hu, S.; Krisch, A. D.; Nurushev, T. S.; Phelps, R. A.; Ratner, L. G.; Varzar, S. M.; Wong, V. K.; Derbenev, Ya. S.; Lee, S. Y.; Rinckel, T.; Schwandt, P.; Sperisen, F.; Stephenson, E. J.; von Przewoski, B.; Baiod, R.; Russell, A. D.; Ohmori, C.; Sato, H.

    1996-05-01

    Partial Siberian snakes are effective in overcoming imperfection depolarizing resonances, but they may also change the crossing energy for intrinsic depolarizing resonances. We experimentally investigated the effect of a partial Siberian snake near intrinsic depolarizing resonances with stored 140 MeV and 160 MeV polarized proton beams. Using various partial Siberian snake strengths up to 30%, depolarization was observed; this may be due to a change in the spin precession frequency which moves the energy of nearby intrinsic depolarizing resonances.

  4. Status report on the NCSL Intrinsic/Derived Standards Committee

    SciTech Connect

    Pettit, R.B.

    1994-05-01

    The history and present status of the NCSL intrinsic/Derived Standards Committee is presented, including a review of the current published Recommended Intrinsic/Derived Standard Practices (RISPs) and the four Working Groups that are in the process of developing new RISPs. One of the documents under development is a Reference Catalogue that documents important information associated with over forty intrinsic/derived standards. The generic information on each standard in the Catalogue, as well as its Table of contents, are presented.

  5. Intrinsic α helix propensities compact hydrodynamic radii in intrinsically disordered proteins.

    PubMed

    English, Lance R; Tilton, Erin C; Ricard, Benjamin J; Whitten, Steven T

    2017-02-01

    Proteins that lack tertiary stability under normal conditions, known as intrinsically disordered, exhibit a wide range of biological activities. Molecular descriptions for the biology of intrinsically disordered proteins (IDPs) consequently rely on disordered structural models, which in turn require experiments that assess the origins to structural features observed. For example, while hydrodynamic size is mostly insensitive to sequence composition in chemically denatured proteins, IDPs show strong sequence-specific effects in the hydrodynamic radius (Rh ) when measured under normal conditions. To investigate sequence-modulation of IDP Rh , disordered ensembles generated by a hard sphere collision model modified with a structure-based parameterization of the solution energetics were used to parse the contributions of net charge, main chain dihedral angle bias, and excluded volume on hydrodynamic size. Ensembles for polypeptides 10-35 residues in length were then used to establish power-law scaling relationships for comparison to experimental Rh from 26 IDPs. Results showed the expected outcomes of increased hydrodynamic size from increases in excluded volume and net charge, and compaction from chain-solvent interactions. Chain bias representing intrinsic preferences for α helix and polyproline II (PPII ), however, modulated Rh with intricate dependence on the simulated propensities. PPII propensities at levels expected in IDPs correlated with heightened Rh sensitivity to even weak α helix propensities, indicating bias for common (φ, ψ) are important determinants of hydrodynamic size. Moreover, data show that IDP Rh can be predicted from sequence with good accuracy from a small set of physicochemical properties, namely intrinsic conformational propensities and net charge. Proteins 2017; 85:296-311. © 2016 Wiley Periodicals, Inc.

  6. Intrinsic motivation, extrinsic motivation, and learning English as a foreign language.

    PubMed

    Shaikholeslami, Razieh; Khayyer, Mohammad

    2006-12-01

    The objective of this study was to examine the relationships of amotivation, extrinsic motivation, and intrinsic motivation with learning the English language. The 230 Iranian students at Shiraz University were tested using the Language Learning Orientations Scales to measure Amotivation, Extrinsic Motivation, and Intrinsic Motivation as explanatory variables. Grade point average in English exams was selected as a measure of English learning Achievement. Multiple regression analysis revealed that learning Achievement scores were predicted by scores on the Amotivation subscale, Introjected Regulation subscale, Knowledge subscale, and Stimulation subscale, whereas, the External and Identified Regulation and Accomplishment subscales did not have a significant relationship with Achievement. The results are discussed in terms of differences in Iranian context and culture.

  7. Intrinsic galaxy shapes and alignments - I. Measuring and modelling COSMOS intrinsic galaxy ellipticities

    NASA Astrophysics Data System (ADS)

    Joachimi, B.; Semboloni, E.; Bett, P. E.; Hartlap, J.; Hilbert, S.; Hoekstra, H.; Schneider, P.; Schrabback, T.

    2013-05-01

    The statistical properties of the ellipticities of galaxy images depend on how galaxies form and evolve, and therefore constrain models of galaxy morphology, which are key to the removal of the intrinsic alignment contamination of cosmological weak lensing surveys, as well as to the calibration of weak lensing shape measurements. We construct such models based on the halo properties of the Millennium Simulation and confront them with a sample of 90 000 galaxies from the COSMOS Survey, covering three decades in luminosity and redshifts out to z = 2. The ellipticity measurements are corrected for effects of point spread function smearing, spurious image distortions and measurement noise. Dividing galaxies into early, late and irregular types, we find that early-type galaxies have up to a factor of 2 lower intrinsic ellipticity dispersion than late-type galaxies. None of the samples shows evidence for redshift evolution, while the ellipticity dispersion for late-type galaxies scales strongly with absolute magnitude at the bright end. The simulation-based models reproduce the main characteristics of the intrinsic ellipticity distributions although which model fares best depends on the selection criteria of the galaxy sample. We observe fewer close-to-circular late-type galaxy images in COSMOS than expected for a sample of randomly oriented circular thick discs and discuss possible explanations for this deficit.

  8. Brown University.

    ERIC Educational Resources Information Center

    CAUSE/EFFECT, 1984

    1984-01-01

    The computing at Brown University was formalized in 1960. Computing history, current university computing, and a description of the Institute for Research in Information and Scholarship are discussed. The installation of a broadband communications network (BRUNET) was recently completed. (MLW)

  9. Rapid identification of microorganisms by intrinsic fluorescence

    NASA Astrophysics Data System (ADS)

    Bhatta, Hemant; Goldys, Ewa M.; Learmonth, Robert

    2005-03-01

    Microbial contamination has serious consequences for the industries that use fermentation processes. Common contaminants such as faster growing lactic acid bacteria or wild yeast can rapidly outnumber inoculated culture yeast and produce undesirable end products. Our study focuses on a rapid method of identification of such contaminants based on autofluorescence spectroscopy of bacterial and yeast species. Lactic acid bacteria (Lac-tobacillus casei), and yeast (Saccharomyces cerevisiae) were cultured under controlled conditions and studied for variations in their autofluorescence. We observed spectral differences in the spectral range representative of tryptophan residues of proteins, with excitation at 290 nm and emission scanned in the 300 nm - 440 nm range. Excitation scans between 240 nm and 310 nm were also performed for the emission at 340 nm. Moreover, we observed clearly pronounced differences in the excitation and emission in the visible range, with 410 nm excitation. These results demonstrate that bacterial and yeast species can be differentiated using their intrinsic fluorescence both in UV and in the visible region. The comparative spectroscopic study of selected strains of Saccharomyces yeast showed clear differences between strains. Spectrally-resolved laser scanning microscopy was carried out to link the results obtained using ensembles of cells with spectral properties of individual cells. Strongly fluorescent subpopulation were observed for all yeast strains with excitation at 405 nm. The fluorescence spectra showed variations correlated with cell brightness. The presented results demonstrate that using autofluorescence, it is possible to differentiate between yeast and lactic acid bacteria and between different yeast species.

  10. Intrinsic Circuits in the Lateral Central Amygdala

    PubMed Central

    Hunt, Sarah; Sun, Yajie; Klein, Rüdiger

    2017-01-01

    Abstract Network activity in the lateral central amygdala (CeL) plays a crucial role in fear learning and emotional processing. However, the local circuits of the CeL are not fully understood and have only recently begun to be explored in detail. Here, we characterized the intrinsic circuits in the CeL using paired whole-call patch-clamp recordings, immunohistochemistry, and optogenetics in C57BL/6J wild-type and somatostatin-cre (SOM-Cre) mice. Our results revealed that throughout the rostrocaudal extent of the CeL, neurons form inhibitory connections at a rate of ∼29% with an average amplitude of 20 ± 3 pA (at −40 mV). Inhibitory input from a single neuron is sufficient to halt firing in the postsynaptic neuron. Post hoc immunostaining for protein kinase Cδ (PKCδ) in wild-type mice and paired recordings in SOM-Cre mice demonstrated that the most common local connections were PKCδ(−) → PKCδ(−) and SOM(+) → SOM(+). Finally, by optogenetically activating either SOM(+) or SOM(−) neurons, we found that almost all neurons in the CeL were innervated by these neuronal populations and that connections between like neurons were stronger than those between different neuronal types. These findings reveal a complex network of connections within the CeL and provide the foundations for future behavior-specific circuit analysis of this complex network. PMID:28374004

  11. Exploiting intrinsic fluctuations to identify model parameters.

    PubMed

    Zimmer, Christoph; Sahle, Sven; Pahle, Jürgen

    2015-04-01

    Parameterisation of kinetic models plays a central role in computational systems biology. Besides the lack of experimental data of high enough quality, some of the biggest challenges here are identification issues. Model parameters can be structurally non-identifiable because of functional relationships. Noise in measured data is usually considered to be a nuisance for parameter estimation. However, it turns out that intrinsic fluctuations in particle numbers can make parameters identifiable that were previously non-identifiable. The authors present a method to identify model parameters that are structurally non-identifiable in a deterministic framework. The method takes time course recordings of biochemical systems in steady state or transient state as input. Often a functional relationship between parameters presents itself by a one-dimensional manifold in parameter space containing parameter sets of optimal goodness. Although the system's behaviour cannot be distinguished on this manifold in a deterministic framework it might be distinguishable in a stochastic modelling framework. Their method exploits this by using an objective function that includes a measure for fluctuations in particle numbers. They show on three example models, immigration-death, gene expression and Epo-EpoReceptor interaction, that this resolves the non-identifiability even in the case of measurement noise with known amplitude. The method is applied to partially observed recordings of biochemical systems with measurement noise. It is simple to implement and it is usually very fast to compute. This optimisation can be realised in a classical or Bayesian fashion.

  12. Intrinsic Turbulence Stabilization in a Stellarator

    NASA Astrophysics Data System (ADS)

    Xanthopoulos, P.; Plunk, G. G.; Zocco, A.; Helander, P.

    2016-04-01

    The magnetic surfaces of modern stellarators are characterized by complex, carefully optimized shaping and exhibit locally compressed regions of strong turbulence drive. Massively parallel computer simulations of plasma turbulence reveal, however, that stellarators also possess two intrinsic mechanisms to mitigate the effect of this drive. In the regime where the length scale of the turbulence is very small compared to the equilibrium scale set by the variation of the magnetic field, the strongest fluctuations form narrow bandlike structures on the magnetic surfaces. Thanks to this localization, the average transport through the surface is significantly smaller than that predicted at locations of peak turbulence. This feature results in a numerically observed upshift of the onset of turbulence on the surface towards higher ion temperature gradients as compared with the prediction from the most unstable regions. In a second regime lacking scale separation, the localization is lost and the fluctuations spread out on the magnetic surface. Nonetheless, stabilization persists through the suppression of the large eddies (relative to the equilibrium scale), leading to a reduced stiffness for the heat flux dependence on the ion temperature gradient. These fundamental differences with tokamak turbulence are exemplified for the QUASAR stellarator [G. H. Neilson et al., IEEE Trans. Plasma Sci. 42, 489 (2014)].

  13. Adaptive Responses Limited by Intrinsic Noise.

    PubMed

    Shankar, Prabhat; Nishikawa, Masatoshi; Shibata, Tatsuo

    2015-01-01

    Sensory systems have mechanisms to respond to the external environment and adapt to them. Such adaptive responses are effective for a wide dynamic range of sensing and perception of temporal change in stimulus. However, noise generated by the adaptation system itself as well as extrinsic noise in sensory inputs may impose a limit on the ability of adaptation systems. The relation between response and noise is well understood for equilibrium systems in the form of fluctuation response relation. However, the relation for nonequilibrium systems, including adaptive systems, are poorly understood. Here, we systematically explore such a relation between response and fluctuation in adaptation systems. We study the two network motifs, incoherent feedforward loops (iFFL) and negative feedback loops (nFBL), that can achieve perfect adaptation. We find that the response magnitude in adaption systems is limited by its intrinsic noise, implying that higher response would have higher noise component as well. Comparing the relation of response and noise in iFFL and nFBL, we show that whereas iFFL exhibits adaptation over a wider parameter range, nFBL offers higher response to noise ratio than iFFL. We also identify the condition that yields the upper limit of response for both network motifs. These results may explain the reason of why nFBL seems to be more abundant in nature for the implementation of adaption systems.

  14. Visualization of Turbulence-Generated Intrinsic Rotation

    NASA Astrophysics Data System (ADS)

    Feibush, Eliot; Ethier, Stephane; Wang, Weixing; Tang, William

    2012-10-01

    A new visualization has been developed of the 3D vector field of plasma flow computed by global gyrokinetic simulations using the GTS code. The visualization shows the direction, magnitude, and structure of turbulence-generated intrinsic rotation in a tokamak. Vectors indicate the clockwise and counter-clockwise flows around the torus. Color-coded vectors are drawn at each grid point on the poloidal planes. A color scale was developed to maximize contrast within the most heavily populated range of data while preserving visibility of the global minimum and maximum values. Technical highlights include transferring large amounts of simulation data from NERSC to PPPL using multiple streams, parallel rendering by the VisIt software, and multiple nx client sessions connecting to a persistent server session. Each of the 1,000 time steps is rendered to a high definition image. The images are assembled into an animated movie that is compressed for efficient, high quality playback. A workflow is in place for producing visualizations of new simulations.

  15. Does intrinsic motivation enhance motor cortex excitability?

    PubMed

    Radel, Rémi; Pjevac, Dusan; Davranche, Karen; d'Arripe-Longueville, Fabienne; Colson, Serge S; Lapole, Thomas; Gruet, Mathieu

    2016-11-01

    Intrinsic motivation (IM) is often viewed as a spontaneous tendency for action. Recent behavioral and neuroimaging evidence indicate that IM, in comparison to extrinsic motivation (EM), solicits the motor system. Accordingly, we tested whether IM leads to greater excitability of the motor cortex than EM. To test this hypothesis, we used two different tasks to induce the motivational orientation using either words representing each motivational orientation or pictures previously linked to each motivational orientation through associative learning. Single-pulse transcranial magnetic stimulation over the motor cortex was applied when viewing the stimuli. Electromyographic activity was recorded on the contracted first dorsal interosseous muscle. Two indexes of corticospinal excitability (the amplitude of motor-evoked potential and the length of cortical silent period) were obtained through unbiased automatic detection and analyzed using a mixed model that provided both statistical power and a high level of control over all important individual, task, and stimuli characteristics. Across the two tasks and the two indices of corticospinal excitability, the exposure to IM-related stimuli did not lead to a greater corticospinal excitability than EM-related stimuli or than stimuli with no motivational valence (ps > .20). While these results tend to dismiss the advantage of IM at activating the motor cortex, we suggest alternative hypotheses to explain this lack of effect, which deserves further research.

  16. Intrinsic ferromagnetism in hexagonal boron nitride nanosheets

    SciTech Connect

    Si, M. S.; Gao, Daqiang E-mail: xueds@lzu.edu.cn; Yang, Dezheng; Peng, Yong; Zhang, Z. Y.; Xue, Desheng E-mail: xueds@lzu.edu.cn; Liu, Yushen; Deng, Xiaohui; Zhang, G. P.

    2014-05-28

    Understanding the mechanism of ferromagnetism in hexagonal boron nitride nanosheets, which possess only s and p electrons in comparison with normal ferromagnets based on localized d or f electrons, is a current challenge. In this work, we report an experimental finding that the ferromagnetic coupling is an intrinsic property of hexagonal boron nitride nanosheets, which has never been reported before. Moreover, we further confirm it from ab initio calculations. We show that the measured ferromagnetism should be attributed to the localized π states at edges, where the electron-electron interaction plays the role in this ferromagnetic ordering. More importantly, we demonstrate such edge-induced ferromagnetism causes a high Curie temperature well above room temperature. Our systematical work, including experimental measurements and theoretical confirmation, proves that such unusual room temperature ferromagnetism in hexagonal boron nitride nanosheets is edge-dependent, similar to widely reported graphene-based materials. It is believed that this work will open new perspectives for hexagonal boron nitride spintronic devices.

  17. Intrinsic ferromagnetism in hexagonal boron nitride nanosheets.

    PubMed

    Si, M S; Gao, Daqiang; Yang, Dezheng; Peng, Yong; Zhang, Z Y; Xue, Desheng; Liu, Yushen; Deng, Xiaohui; Zhang, G P

    2014-05-28

    Understanding the mechanism of ferromagnetism in hexagonal boron nitride nanosheets, which possess only s and p electrons in comparison with normal ferromagnets based on localized d or f electrons, is a current challenge. In this work, we report an experimental finding that the ferromagnetic coupling is an intrinsic property of hexagonal boron nitride nanosheets, which has never been reported before. Moreover, we further confirm it from ab initio calculations. We show that the measured ferromagnetism should be attributed to the localized π states at edges, where the electron-electron interaction plays the role in this ferromagnetic ordering. More importantly, we demonstrate such edge-induced ferromagnetism causes a high Curie temperature well above room temperature. Our systematical work, including experimental measurements and theoretical confirmation, proves that such unusual room temperature ferromagnetism in hexagonal boron nitride nanosheets is edge-dependent, similar to widely reported graphene-based materials. It is believed that this work will open new perspectives for hexagonal boron nitride spintronic devices.

  18. Intrinsic ferromagnetism in hexagonal boron nitride nanosheets

    NASA Astrophysics Data System (ADS)

    Si, M. S.; Gao, Daqiang; Yang, Dezheng; Peng, Yong; Zhang, Z. Y.; Xue, Desheng; Liu, Yushen; Deng, Xiaohui; Zhang, G. P.

    2014-05-01

    Understanding the mechanism of ferromagnetism in hexagonal boron nitride nanosheets, which possess only s and p electrons in comparison with normal ferromagnets based on localized d or f electrons, is a current challenge. In this work, we report an experimental finding that the ferromagnetic coupling is an intrinsic property of hexagonal boron nitride nanosheets, which has never been reported before. Moreover, we further confirm it from ab initio calculations. We show that the measured ferromagnetism should be attributed to the localized π states at edges, where the electron-electron interaction plays the role in this ferromagnetic ordering. More importantly, we demonstrate such edge-induced ferromagnetism causes a high Curie temperature well above room temperature. Our systematical work, including experimental measurements and theoretical confirmation, proves that such unusual room temperature ferromagnetism in hexagonal boron nitride nanosheets is edge-dependent, similar to widely reported graphene-based materials. It is believed that this work will open new perspectives for hexagonal boron nitride spintronic devices.

  19. Genomic Insights into Diffuse Intrinsic Pontine Glioma

    PubMed Central

    Lapin, Danielle H.; Tsoli, Maria; Ziegler, David S.

    2017-01-01

    Diffuse intrinsic pontine glioma (DIPG) is a highly aggressive pediatric brainstem tumor with a peak incidence in middle childhood and a median survival of less than 1 year. The dismal prognosis associated with DIPG has been exacerbated by the failure of over 250 clinical trials to meaningfully improve survival compared with radiotherapy, the current standard of care. The traditional practice to not biopsy DIPG led to a scarcity in available tissue samples for laboratory analysis that till recently hindered therapeutic advances. Over the past few years, the acquisition of patient derived tumor samples through biopsy and autopsy protocols has led to distinct breakthroughs in the identification of key oncogenic drivers implicated in DIPG development. Aberrations have been discovered in critical genetic drivers including histone H3, ACVR1, TP53, PDGFRA, and Myc. Mutations, previously not identified in other malignancies, highlight DIPG as a distinct biological entity. Identification of novel markers has already greatly influenced the direction of preclinical investigations and offers the exciting possibility of establishing biologically targeted therapies. This review will outline the current knowledge of the genomic landscape related to DIPG, overview preclinical investigations, and reflect how biological advances have influenced the focus of clinical trials toward targeted therapies.

  20. Exploiting protein intrinsic flexibility in drug design.

    PubMed

    Lukman, Suryani; Verma, Chandra S; Fuentes, Gloria

    2014-01-01

    Molecular recognition in biological systems relies on the existence of specific attractive interactions between two partner molecules. Structure-based drug design seeks to identify and optimize such interactions between ligands and their protein targets. The approach followed in medicinal chemistry follows a combination of careful analysis of structural data together with experimental and/or theoretical studies on the system. This chapter focuses on the fact that a protein is not fully characterized by a single structure, but by an ensemble of states, some of them represent "hidden conformations" with cryptic binding sites. We highlight case studies where both experimental and computational methods have been used to mutually drive each other in an attempt to improve the success of the drug design approaches.Advances in both experimental techniques and computational methods have greatly improved our physico-chemical understanding of the functional mechanisms in biomolecules and opened a debate about the interplay between molecular structure and biomolecular function. The beautiful static pictures of protein structures may have led to neglecting the intrinsic protein flexibility, however we are entering a new era where more sophisticated methods are used to exploit this ability of macromolecules, and this will definitely lead to the inclusion of the notion in the pharmaceutical field of drug design.

  1. Intrinsic and extrinsic measurement for Brownian motion

    NASA Astrophysics Data System (ADS)

    Castro-Villarreal, Pavel

    2014-05-01

    Based upon the Smoluchowski equation on curved manifolds, three physical observables are considered for Brownian displacement, namely geodesic displacement s, Euclidean displacement δR, and projected displacement δR⊥. The Weingarten-Gauss equations are used to calculate the mean-square Euclidean displacements in the short-time regime. Our findings show that from an extrinsic point of view the geometry of the space affects the Brownian motion in such a way that the particle’s diffusion is decelerated, contrasting with the intrinsic point of view where dynamics is controlled by the sign of the Gaussian curvature (Castro-Villarreal, 2010 J. Stat. Mech. P08006). Furthermore, it is possible to give exact formulas for <δR> and <δR2> on spheres and minimal surfaces, which are valid for all values of time. In the latter case, surprisingly, Brownian motion corresponds to the usual diffusion in flat geometries, albeit minimal surfaces have non-zero Gaussian curvature. Finally, the two-dimensional case is emphasized due to its close relation to surface self-diffusion in fluid membranes.

  2. Intrinsic Photosensitivity Enhances Motility of T Lymphocytes

    PubMed Central

    Phan, Thieu X.; Jaruga, Barbara; Pingle, Sandeep C.; Bandyopadhyay, Bidhan C.; Ahern, Gerard P.

    2016-01-01

    Sunlight has important biological effects in human skin. Ultraviolet (UV) light striking the epidermis catalyzes the synthesis of Vitamin D and triggers melanin production. Although a causative element in skin cancers, sunlight is also associated with positive health outcomes including reduced incidences of autoimmune diseases and cancers. The mechanisms, however, by which light affects immune function remain unclear. Here we describe direct photon sensing in human and mouse T lymphocytes, a cell-type highly abundant in skin. Blue light irradiation at low doses (<300 mJ cm−2) triggers synthesis of hydrogen peroxide (H2O2) in T cells revealed by the genetically encoded reporter HyPerRed. In turn, H2O2 activates a Src kinase/phospholipase C-γ1 (PLC-γ1) signaling pathway and Ca2+ mobilization. Pharmacologic inhibition or genetic disruption of Lck kinase, PLC-γ1 or the T cell receptor complex inhibits light-evoked Ca2+ transients. Notably, both light and H2O2 enhance T-cell motility in a Lck-dependent manner. Thus, T lymphocytes possess intrinsic photosensitivity and this property may enhance their motility in skin. PMID:27995987

  3. Intrinsic valley Hall effect in graphene

    NASA Astrophysics Data System (ADS)

    Yang, Mou; Zhang, Wen-Lian; Liu, Hai; Bai, Yan-Kui

    2017-04-01

    If electrons are incident from an armchair graphene ribbon into the bulk graphene region, the electronic diffraction occurs. Because of the different triangular wrapping of the energy dispersion between valleys K and K ‧ , the electrons of valley K tend to be diffracted to one side and those of valley K ‧ to the other side. When the current is injected from the armchair ribbon of a four-terminal graphene device, the major portion of the incident current of valley K flows through one side arm and the minor portion through the other side arm. The ratio between them is derived to be 1 + 4 E / 3 in the low energy limit, where E is the energy in units of hopping parameter. The major arm for valley K is the minor arm for valley K ‧ . This results in the rise of the valley Hall effect, which is an intrinsic property of graphene stemming from the different electronic structure of the two valleys. The valley Hall conductance is calculated to be (2 E / 3)G0 with G0 being the conductance supported by the injection ribbon.

  4. Understanding Oceanic Migrations with Intrinsic Biogeochemical Markers

    PubMed Central

    Ramos, Raül; González-Solís, Jacob; Croxall, John P.; Oro, Daniel

    2009-01-01

    Migratory marine vertebrates move annually across remote oceanic water masses crossing international borders. Many anthropogenic threats such as overfishing, bycatch, pollution or global warming put millions of marine migrants at risk especially during their long-distance movements. Therefore, precise knowledge about these migratory movements to understand where and when these animals are more exposed to human impacts is vital for addressing marine conservation issues. Because electronic tracking devices suffer from several constraints, mainly logistical and financial, there is emerging interest in finding appropriate intrinsic markers, such as the chemical composition of inert tissues, to study long-distance migrations and identify wintering sites. Here, using tracked pelagic seabirds and some of their own feathers which were known to be grown at different places and times within the annual cycle, we proved the value of biogeochemical analyses of inert tissue as tracers of marine movements and habitat use. Analyses of feathers grown in summer showed that both stable isotope signatures and element concentrations can signal the origin of breeding birds feeding in distinct water masses. However, only stable isotopes signalled water masses used during winter because elements mainly accumulated during the long breeding period are incorporated into feathers grown in both summer and winter. Our findings shed new light on the simple and effective assignment of marine organisms to distinct oceanic areas, providing new opportunities to study unknown migration patterns of secretive species, including in relation to human-induced mortality on specific populations in the marine environment. PMID:19623244

  5. Trees, bialgebras and intrinsic numerical algorithms

    NASA Technical Reports Server (NTRS)

    Crouch, Peter; Grossman, Robert; Larson, Richard

    1990-01-01

    Preliminary work about intrinsic numerical integrators evolving on groups is described. Fix a finite dimensional Lie group G; let g denote its Lie algebra, and let Y(sub 1),...,Y(sub N) denote a basis of g. A class of numerical algorithms is presented that approximate solutions to differential equations evolving on G of the form: dot-x(t) = F(x(t)), x(0) = p is an element of G. The algorithms depend upon constants c(sub i) and c(sub ij), for i = 1,...,k and j is less than i. The algorithms have the property that if the algorithm starts on the group, then it remains on the group. In addition, they also have the property that if G is the abelian group R(N), then the algorithm becomes the classical Runge-Kutta algorithm. The Cayley algebra generated by labeled, ordered trees is used to generate the equations that the coefficients c(sub i) and c(sub ij) must satisfy in order for the algorithm to yield an rth order numerical integrator and to analyze the resulting algorithms.

  6. Intrinsic Dynamic Behavior of Fascin in Filopodia

    PubMed Central

    Schaus, Thomas E.; Taylor, Edwin W.; Borisy, Gary G.

    2007-01-01

    Recent studies showed that the actin cross-linking protein, fascin, undergoes rapid cycling between filopodial filaments. Here, we used an experimental and computational approach to dissect features of fascin exchange and incorporation in filopodia. Using expression of phosphomimetic fascin mutants, we determined that fascin in the phosphorylated state is primarily freely diffusing, whereas actin bundling in filopodia is accomplished by fascin dephosphorylated at serine 39. Fluorescence recovery after photobleaching analysis revealed that fascin rapidly dissociates from filopodial filaments with a kinetic off-rate of 0.12 s−1 and that it undergoes diffusion at moderate rates with a coefficient of 6 μm2s−1. This kinetic off-rate was recapitulated in vitro, indicating that dynamic behavior is intrinsic to the fascin cross-linker. A computational reaction–diffusion model showed that reversible cross-linking is required for the delivery of fascin to growing filopodial tips at sufficient rates. Analysis of fascin bundling indicated that filopodia are semiordered bundles with one bound fascin per 25–60 actin monomers. PMID:17671164

  7. Adaptive Responses Limited by Intrinsic Noise

    PubMed Central

    Shankar, Prabhat; Nishikawa, Masatoshi; Shibata, Tatsuo

    2015-01-01

    Sensory systems have mechanisms to respond to the external environment and adapt to them. Such adaptive responses are effective for a wide dynamic range of sensing and perception of temporal change in stimulus. However, noise generated by the adaptation system itself as well as extrinsic noise in sensory inputs may impose a limit on the ability of adaptation systems. The relation between response and noise is well understood for equilibrium systems in the form of fluctuation response relation. However, the relation for nonequilibrium systems, including adaptive systems, are poorly understood. Here, we systematically explore such a relation between response and fluctuation in adaptation systems. We study the two network motifs, incoherent feedforward loops (iFFL) and negative feedback loops (nFBL), that can achieve perfect adaptation. We find that the response magnitude in adaption systems is limited by its intrinsic noise, implying that higher response would have higher noise component as well. Comparing the relation of response and noise in iFFL and nFBL, we show that whereas iFFL exhibits adaptation over a wider parameter range, nFBL offers higher response to noise ratio than iFFL. We also identify the condition that yields the upper limit of response for both network motifs. These results may explain the reason of why nFBL seems to be more abundant in nature for the implementation of adaption systems. PMID:26305221

  8. Toward a tripartite model of intrinsic motivation.

    PubMed

    Carbonneau, Noémie; Vallerand, Robert J; Lafrenière, Marc-André K

    2012-10-01

    Intrinsic motivation (IM) refers to engaging in an activity for the pleasure inherent in the activity. The present article presents a tripartite model of IM consisting of IM to know (i.e., engaging in an activity to experience pleasure while learning and trying to understand something new), IM toward accomplishment (i.e., engaging in an activity for the pleasure experienced when attempting task mastery), and IM to experience stimulation (i.e., engaging in an activity for feelings of sensory pleasure). The tripartite model of IM posits that each type of IM can result from task, situational, and personality determinants and can lead to specific types of cognitive, affective, and behavioral outcomes. The purpose of this research was to test some predictions derived from this model. Across 4 studies (Study 1: N = 331; Study 2: N = 113; Study 3: N = 58; Study 4: N = 135), the 3 types of IM as well as potential determinants and consequences were assessed. Results revealed that experiencing one type of IM over the others depends in part on people's personality styles. Also, each type of IM was found to predict specific outcomes (i.e., affective states and behavioral choices). The implications of the tripartite model of IM for motivation research are discussed.

  9. Functional Anthology of Intrinsic Disorder. III. Ligands, Postranslational Modifications and Diseases Associated with Intrinsically Disordered Proteins

    PubMed Central

    Xie, Hongbo; Vucetic, Slobodan; Iakoucheva, Lilia M.; Oldfield, Christopher J.; Dunker, A. Keith; Obradovic, Zoran; Uversky, Vladimir N.

    2008-01-01

    Currently, the understanding of the relationships between function, amino acid sequence and protein structure continues to represent one of the major challenges of the modern protein science. As much as 50% of eukaryotic proteins are likely to contain functionally important long disordered regions. Many proteins are wholly disordered but still possess numerous biologically important functions. However, the number of experimentally confirmed disordered proteins with known biological functions is substantially smaller than their actual number in nature. Therefore, there is a crucial need for novel bioinformatics approaches that allow projection of the current knowledge from a few experimentally verified examples to much larger groups of known and potential proteins. The elaboration of a bioinformatics tool for the analysis of functional diversity of intrinsically disordered proteins and application of this data mining tool to >200,000 proteins from Swiss-Prot database, each annotated with at least one of the 875 functional keywords was described in the first paper of this series (Xie H., Vucetic S., Iakoucheva L.M., Oldfield C.J., Dunker A.K., Obradovic Z., Uversky V.N. (2006) Functional anthology of intrinsic disorder. I. Biological processes and functions of proteins with long disordered regions. J. Proteome Res.). Using this tool, we have found that out of the 711 Swiss-Prot functional keywords associated with at least 20 proteins, 262 were strongly positively correlated with long intrinsically disordered regions, and 302 were strongly negatively correlated. Illustrative examples of functional disorder or order were found for the vast majority of keywords showing strongest positive or negative correlation with intrinsic disorder, respectively. Some 80 Swiss-Prot keywords associated with disorder- and order-driven biological processes and protein functions were described in the first paper (Xie H., Vucetic S., Iakoucheva L.M., Oldfield C.J., Dunker A.K., Obradovic

  10. Surgical Treatment Guidelines for Digital Deformity Associated With Intrinsic Muscle Spasticity (Intrinsic Plus Foot) in Adults With Cerebral Palsy.

    PubMed

    Boffeli, Troy J; Collier, Rachel C

    2015-01-01

    Intrinsic plus foot deformity has primarily been associated with cerebral palsy and involves spastic contracture of the intrinsic musculature with resultant toe deformities. Digital deformity is caused by a dynamic imbalance between the intrinsic muscles in the foot and extrinsic muscles in the lower leg. Spastic contracture of the toes frequently involves curling under of the lesser digits or contracture of the hallux into valgus or plantarflexion deformity. Patients often present with associated pressure ulcers, deformed toenails, shoe or brace fitting challenges, and pain with ambulation or transfers. Four different patterns of intrinsic plus foot deformity have been observed by the authors that likely relate to the different patterns of muscle involvement. Case examples are provided of the 4 patterns of intrinsic plus foot deformity observed, including global intrinsic plus lesser toe deformity, isolated intrinsic plus lesser toe deformity, intrinsic plus hallux valgus deformity, and intrinsic plus hallux flexus deformity. These case examples are presented to demonstrate each type of deformity and our approach for surgical management according to the contracture pattern. The surgical approach has typically involved tenotomy, capsulotomy, or isolated joint fusion. The main goals of surgical treatment are to relieve pain and reduce pressure points through digital realignment in an effort to decrease the risk of pressure sores and allow more effective bracing to ultimately improve the patient's mobility.

  11. Scotland's Universities.

    ERIC Educational Resources Information Center

    Bell, R. E.

    2000-01-01

    Examines the Scottish university tradition and the origins and particulars of Scottish-Anglo differences in higher education. Discusses the 19th-century growth of Scottish universities, which lacked formal entrance requirements; students' rights and power in the university; academic degrees awarded; relationship with the state; and student…

  12. Self-Determination Theory: Intrinsic Motivation and Behavioral Change.

    PubMed

    Flannery, Marie

    2017-03-01

    Motivation is a central concept in behavioral change. This article reviews the self-determination theory with an emphasis on "intrinsic motivation," which is facilitated when three basic psychological needs (autonomy, competence, and relatedness) are met. Intrinsic motivation is associated with improved well-being and sustained behavioral change.

  13. 30 CFR 27.34 - Test for intrinsic safety.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... APPROVAL OF MINING PRODUCTS METHANE-MONITORING SYSTEMS Test Requirements § 27.34 Test for intrinsic safety... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Test for intrinsic safety. 27.34 Section 27.34... various flammable natural gas-air mixtures. To meet the requirements of this test, the spark shall...

  14. 46 CFR 111.105-11 - Intrinsically safe systems.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false Intrinsically safe systems. 111.105-11 Section 111.105-11 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING ELECTRIC..., partitioned by a grounded metal barrier from other non-intrinsically safe electric cables, or a shielded...

  15. Fostering Intrinsic Motivation in Children: A Humanistic Counseling Process

    ERIC Educational Resources Information Center

    Watts, Randolph H., Jr.; Cashwell, Craig S.; Schweiger, Wendi K.

    2004-01-01

    Humanistic counselors working with children seek to help them grow and develop the motivation needed to make decisions and changes in their lives. Intrinsic motivation, an important component of humanistic counseling, is defined and explicated, research is reviewed, and suggestions are made for counselors who seek to foster intrinsic motivation in…

  16. Intrinsic unsharpness and approximate repeatability of quantum measurements

    NASA Astrophysics Data System (ADS)

    Carmeli, Claudio; Heinonen, Teiko; Toigo, Alessandro

    2007-02-01

    The intrinsic unsharpness of a quantum observable is studied by introducing the notion of resolution width. This quantification of accuracy is shown to be closely connected with the possibility of making approximately repeatable measurements. As a case study, the intrinsic unsharpness and approximate repeatability of position and momentum measurements are examined in detail.

  17. 30 CFR 27.34 - Test for intrinsic safety.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Test for intrinsic safety. 27.34 Section 27.34 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR TESTING, EVALUATION, AND APPROVAL OF MINING PRODUCTS METHANE-MONITORING SYSTEMS Test Requirements § 27.34 Test for intrinsic...

  18. Extrinsic and Intrinsic Motivation at 30: Unresolved Scientific Issues

    ERIC Educational Resources Information Center

    Reiss, Steven

    2005-01-01

    The undermining effect of extrinsic reward on intrinsic motivation remains unproven. The key unresolved issues are construct invalidity (all four definitions are unproved and two are illogical); measurement unreliability (the free-choice measure requires unreliable, subjective judgments to infer intrinsic motivation); inadequate experimental…

  19. The Intrinsic Value of Nature and Moral Education

    ERIC Educational Resources Information Center

    Helton, William S.; Helton, Nicole D.

    2007-01-01

    Many environmental, humane and character educators try to foster a belief in the intrinsic value of nature and a respect for non-human life among students. Marangudakis argues that Christianity advocates anthropocentrism and opposes belief in the intrinsic value of nature. If Marangudakis is correct, then a goal of many environmental and humane…

  20. Adolescents' Perceptions of Family Connectedness, Intrinsic Religiosity, and Depressed Mood

    ERIC Educational Resources Information Center

    Houltberg, Benjamin J.; Henry, Carolyn S.; Merten, Michael J.; Robinson, Linda C.

    2011-01-01

    Using a sample of 248 ninth and tenth grade students at public high schools, we examined adolescents' perceptions of family connectedness, intrinsic religiosity, and adolescents' gender in relation to depressed mood and whether intrinsic religiosity and gender moderated the association of aspects of family connectedness to adolescent depressed…

  1. Creativity as Mediator for Intrinsic Motivation and Sales Performance

    ERIC Educational Resources Information Center

    Bodla, Mahmood A.; Naeem, Basharat

    2014-01-01

    Substantial theoretical and empirical literature indicates inconsistent performance implications of intrinsic motivation, suggesting the possibility of some explanatory mechanisms. However, little is known about the factors that might explain intrinsic motivation and sales force performance relation, particularly in highly competitive and…

  2. Intrinsic and Extrinsic Motivation for Stereotypic and Repetitive Behavior

    ERIC Educational Resources Information Center

    Joosten, Annette V.; Bundy, Anita C.; Einfeld, Stewart L.

    2009-01-01

    This study provides evidence for intrinsic and extrinsic motivators for stereotypical and repetitive behavior in children with autism and intellectual disability and children with intellectual disability alone. We modified the Motivation Assessment Scale (MAS) (1988b); dividing it into intrinsic and extrinsic measures and adding items to assess…

  3. The Work Values of First Year Spanish University Students

    ERIC Educational Resources Information Center

    Cortés-Pascual, P. A.; Cano-Escoriaza, J.; Orejudo, S.

    2014-01-01

    This study analyzes the work values of 2,951 first-year university students in Spain enrolled in degree programs within the five major areas of university studies. For our research, participants were asked to respond to a Scale of Work Values in which intrinsic, social, and pragmatic extrinsic values as well as extrinsic values related to…

  4. Intrinsic Wavelength Shifts in Stellar Spectra

    NASA Astrophysics Data System (ADS)

    Dravins, D.; Lindegren, L.; Ludwig, H.-G.; Madsen, S.

    2004-12-01

    Wavelengths of stellar spectral lines do not have the precise values `naively' expected from laboratory wavelengths merely Doppler-shifted by stellar radial motion. Slight displacements may originate as convective shifts (correlated velocity and brightness patterns in the photosphere), as gravitational redshifts, or perhaps be induced by wave motions. Intrinsic lineshifts thus reveal stellar surface structure, while possible periodic changes (during a stellar activity cycle, say) need to be segregated from variability induced by orbiting exoplanets. Absolute lineshifts can now be studied also in some stars other than the Sun, thanks to astrometric determinations of stellar radial motion. Comparisons between spectroscopic apparent radial velocities and astrometrically determined radial motions reveal greater spectral blueshifts in F-type stars than in the Sun (as theoretically expected from their more vigorous convection), further increasing in A-type stars (possibly due to atmospheric shockwaves). Solar spectral atlases, and high-resolution spectra (from UVES on ESO VLT) of a dozen solar-type stars are being surveyed for `unblended' photospheric lines of most atomic species with accurate laboratory wavelengths available. One aim is to understand the ultimate information content of stellar spectra, and in what detail it will be feasible to verify models of stellar atmospheric hydrodynamics. These may predict line asymmetries (bisectors) and shifts for widely different classes of lines, but there will not result any comparison with observations if such lines do not exist in real spectra. An expected near-future development in stellar physics is spatially resolved spectroscopy across stellar disks, enabled by optical interferometry and adaptive optics on very large telescopes. Stellar surface structure manifests itself in the center-to-limb wavelength changes along a stellar diameter, and their spatially resolved time variability, diagnostics which already now can be

  5. Intrinsic Organization of the Anesthetized Brain

    PubMed Central

    Liang, Zhifeng; King, Jean; Zhang, Nanyin

    2012-01-01

    The neural mechanism of unconsciousness has been a major unsolved question in neuroscience despite its vital role in brain states like coma and anesthesia. The existing literature suggests that neural connections, information integration and conscious states are closely related. Indeed, alterations in several important neural circuitries and networks during unconscious conditions have been reported. However, how the whole-brain network is topologically reorganized to support different patterns of information transfer at unconscious states remains unknown. Here we directly compared whole-brain neural networks in an awake and an anesthetized state in rodents. Consistent with our previous report, the awake rat brain was organized in a non-trivial manner and conserved fundamental topological properties as the human brain. Strikingly, these topological features were well maintained in the anesthetized brain. Meanwhile, local neural networks were reorganized with altered local network properties. The connectional strength between brain regions was also considerably different between the awake and anesthetized conditions. Interestingly, we found that long-distance connections were not preferentially reduced in the anesthetized condition, arguing against the hypothesis that loss of long-distance connections is characteristic to unconsciousness. These findings collectively show that the integrity of the whole-brain network can be conserved between widely dissimilar physiologic states while local neural networks can flexibly adapt to new conditions. They also illustrate that the governing principles of intrinsic brain organization might represent fundamental characteristics of the healthy brain. With the unique spatial and temporal scales of rsfMRI, this study has opened a new avenue for understanding the neural mechanism of (un)consciousness. PMID:22836253

  6. Intrinsic motivation and sportsmanship: mediating role of interpersonal relationships.

    PubMed

    Núñez, Juan L; Martín-Albo, José; Navarro, José G; Sánchez, Juana M; González-Cutre, David

    2009-06-01

    This study analyzed the mediating role of interpersonal relations between intrinsic motivation and sportsmanship. Athletes (98 men, 97 women), ages 11 to 43 years, completed measures of intrinsic motivation toward sports, self-concept of social and family relations, and sportsmanship orientation. A structural equation model indicated that self-concept of interpersonal relations mediated the relation between intrinsic motivation and sportsmanship. Also, intrinsic motivation was directly and positively associated with self-concept of interpersonal relations, which, in turn, was positively and significantly related to sportsmanship. Variances explained by self-concept of interpersonal relations and by sportsmanship were 32 and 56%, respectively. The motivational interaction between the context of interpersonal relations and the sports context proposed in the hierarchical model of intrinsic and extrinsic motivation was discussed.

  7. An intrinsic timer specifies distal structures of the vertebrate limb.

    PubMed

    Saiz-Lopez, Patricia; Chinnaiya, Kavitha; Campa, Victor M; Delgado, Irene; Ros, Maria A; Towers, Matthew

    2015-09-18

    How the positional values along the proximo-distal axis (stylopod-zeugopod-autopod) of the limb are specified is intensely debated. Early work suggested that cells intrinsically change their proximo-distal positional values by measuring time. Recently, however, it is suggested that instructive extrinsic signals from the trunk and apical ectodermal ridge specify the stylopod and zeugopod/autopod, respectively. Here, we show that the zeugopod and autopod are specified by an intrinsic timing mechanism. By grafting green fluorescent protein-expressing cells from early to late chick wing buds, we demonstrate that distal mesenchyme cells intrinsically time Hoxa13 expression, cell cycle parameters and the duration of the overlying apical ectodermal ridge. In addition, we reveal that cell affinities intrinsically change in the distal mesenchyme, which we suggest results in a gradient of positional values along the proximo-distal axis. We propose a complete model in which a switch from extrinsic signalling to intrinsic timing patterns the vertebrate limb.

  8. Ethnic stigma, academic anxiety, and intrinsic motivation in middle childhood.

    PubMed

    Gillen-O'Neel, Cari; Ruble, Diane N; Fuligni, Andrew J

    2011-01-01

    Previous research addressing the dynamics of stigma and academics has focused on African American adolescents and adults. The present study examined stigma awareness, academic anxiety, and intrinsic motivation among 451 young (ages 6-11) and diverse (African American, Chinese, Dominican, Russian, and European American) students. Results indicated that ethnic-minority children reported higher stigma awareness than European American children. For all children, stigma awareness was associated with higher academic anxiety and lower intrinsic motivation. Despite these associations, ethnic-minority children reported higher levels of intrinsic motivation than their European American peers. A significant portion of the higher intrinsic motivation among Dominican students was associated with their higher levels of school belonging, suggesting that supportive school environments may be important sources of intrinsic motivation among some ethnic-minority children.

  9. Universal structures of normal and pathological heart rate variability.

    PubMed

    Gañán-Calvo, Alfonso M; Fajardo-López, Juan

    2016-02-25

    The circulatory system of living organisms is an autonomous mechanical system softly tuned with the respiratory system, and both developed by evolution as a response to the complex oxygen demand patterns associated with motion. Circulatory health is rooted in adaptability, which entails an inherent variability. Here, we show that a generalized N-dimensional normalized graph representing heart rate variability reveals two universal arrhythmic patterns as specific signatures of health one reflects cardiac adaptability, and the other the cardiac-respiratory rate tuning. In addition, we identify at least three universal arrhythmic profiles whose presences raise in proportional detriment of the two healthy ones in pathological conditions (myocardial infarction; heart failure; and recovery from sudden death). The presence of the identified universal arrhythmic structures together with the position of the centre of mass of the heart rate variability graph provide a unique quantitative assessment of the health-pathology gradient.

  10. Universal structures of normal and pathological heart rate variability

    PubMed Central

    Gañán-Calvo, Alfonso M.; Fajardo-López, Juan

    2016-01-01

    The circulatory system of living organisms is an autonomous mechanical system softly tuned with the respiratory system, and both developed by evolution as a response to the complex oxygen demand patterns associated with motion. Circulatory health is rooted in adaptability, which entails an inherent variability. Here, we show that a generalized N-dimensional normalized graph representing heart rate variability reveals two universal arrhythmic patterns as specific signatures of health one reflects cardiac adaptability, and the other the cardiac-respiratory rate tuning. In addition, we identify at least three universal arrhythmic profiles whose presences raise in proportional detriment of the two healthy ones in pathological conditions (myocardial infarction; heart failure; and recovery from sudden death). The presence of the identified universal arrhythmic structures together with the position of the centre of mass of the heart rate variability graph provide a unique quantitative assessment of the health-pathology gradient. PMID:26912108

  11. New concept to break the intrinsic properties of organic semiconductors for optical sensing applications

    NASA Astrophysics Data System (ADS)

    Choy, Wallace C. H.

    2015-09-01

    As the intrinsic electrostatic limit, space charge limit (SCL) for photocurrent is a universal phenomenon which is fundamental important for organic semiconductors. We will demonstrate SCL breaking by a new plasmonic-electrical concept. As a proof-ofconcept, organic solar cells (OSCs) comprising metallic planar and grating electrodes are studied. Interestingly, although strong plasmonic resonances induce abnormally dense photocarriers around a grating anode, the grating incorporated inverted OSC is exempt from space charge accumulation (limit) and degradation of electrical properties. The plasmonic-electrical concept will open up a new way to manipulate both optical and electrical properties of semiconductor devices simultaneously.

  12. Automated mapping of the ocean floor using the theory of intrinsic random functions of order k

    USGS Publications Warehouse

    David, M.; Crozel, D.; Robb, James M.

    1986-01-01

    High-quality contour maps can be computer drawn from single track echo-sounding data by combining Universal Kriging and the theory of intrinsic random function of order K (IRFK). These methods interpolate values among the closely spaced points that lie along relatively widely spaced lines. The technique provides a variance which can be contoured as a quantitative measure of map precision. The technique can be used to evaluate alternative survey trackline configurations and data collection intervals, and can be applied to other types of oceanographic data. ?? 1986 D. Reidel Publishing Company.

  13. A Census of Intrinsic Narrow Absorption Lines in the Spectra of Quasars at z = 2-4

    NASA Astrophysics Data System (ADS)

    Misawa, Toru; Charlton, Jane C.; Eracleous, Michael; Ganguly, Rajib; Tytler, David; Kirkman, David; Suzuki, Nao; Lubin, Dan

    2007-07-01

    We use Keck HIRES spectra of 37 optically bright quasars at z=2-4 to study narrow absorption lines that are intrinsic to the quasars (intrinsic NALs, produced in gas that is physically associated with the quasar central engine). We identify 150 NAL systems, which contain 124 C IV, 12 N V, and 50 Si IV doublets, of which 18 are associated systems (within 5000 km s-1 of the quasar redshift). We use partial coverage analysis to separate intrinsic NALs from NALs produced in cosmologically intervening structures. We find 39 candidate intrinsic systems (28 reliable determinations and 11 that are possibly intrinsic). We estimate that 10%-17% of C IV systems at blueshifts of 5000-70,000 km s-1 relative to quasars are intrinsic. At least 32% of quasars contain one or more intrinsic C IV NALs. Considering N V and Si IV doublets showing partial coverage as well, at least 50% of quasars host intrinsic NALs. This result constrains the solid angle subtended by the absorbers to the background source(s). We identify two families of intrinsic NAL systems, those with strong N V absorption and those with negligible absorption in N V but with partial coverage in the C IV doublet. We discuss the idea that these two families represent different regions or conditions in accretion disk winds. Of the 26 intrinsic C IV NAL systems, 13 have detectable low-ionization absorption lines at similar velocities, suggesting that these are two-phase structures in the wind rather than absorbers in the host galaxy. We also compare possible models for quasar outflows, including radiatively accelerated disk-driven winds, magnetocentrifugally accelerated winds, and pressure-driven winds, and we discuss ways of distinguishing between these models observationally. The data presented here were obtained at the W. M. Keck Observatory, which is operated as a scientific partnership among the California Institute of Technology, the University of California, and the National Aeronautics and Space Administration

  14. Major intrinsic proteins in biomimetic membranes.

    PubMed

    Nielsen, Claus Hélix

    2010-01-01

    Biological membranes define the structural and functional boundaries in living cells and their organelles. The integrity of the cell depends on its ability to separate inside from outside and yet at the same time allow massive transport of matter in and out the cell. Nature has elegantly met this challenge by developing membranes in the form of lipid bilayers in which specialized transport proteins are incorporated. This raises the question: is it possible to mimic biological membranes and create a membrane based sensor and/or separation device? In the development of a biomimetic sensor/separation technology, a unique class of membrane transport proteins is especially interesting-the major intrinsic proteins (MIPs). Generally, MIPs conduct water molecules and selected solutes in and out of the cell while preventing the passage of other solutes, a property critical for the conservation of the cells internal pH and salt concentration. Also known as water channels or aquaporins they are highly efficient membrane pore proteins some of which are capable of transporting water at very high rates up to 10(9) molecules per second. Some MIPs transport other small, uncharged solutes, such as glycerol and other permeants such as carbon dioxide, nitric oxide, ammonia, hydrogen peroxide and the metalloids antimonite, arsenite, silicic and boric acid depending on the effective restriction mechanism of the protein. The flux properties of MIPs thus lead to the question ifMIPs can be used in separation devices or as sensor devices based on, e.g., the selective permeation of metalloids. In principle a MIP based membrane sensor/separation device requires the supporting biomimetic matrix to be virtually impermeable to anything but water or the solute in question. In practice, however, a biomimetic support matrix will generally have finite permeabilities to both electrolytes and non-electrolytes. The feasibility of a biomimetic MIP device thus depends on the relative transport

  15. Baby universes.

    NASA Astrophysics Data System (ADS)

    Strominger, Andrew

    The following sections are included: * INTRODUCTION * TOPOLOGY CHANGE AND THIRD QUANTIZATION IN 0+1 DIMENSIONS * Third Quantization of Free One-dimensional Universes * Third Quantization of Interacting One-Dimensional Universes * The Single-Universe Approximation and Dynamical Determination of Coupling Constants * The Third Quantized Uncertainty Principle * THIRD QUANTIZATION IN 3+1 DIMENSIONS * The Gauge Invariant Action * Relation to Other Formalisms * PARENT AND BABY UNIVERSES * The Hybrid Action * Baby Universe Field Operators and Spacetime Couplings * INSTANTONS-FROM QUANTUM MECHANICS TO QUANTUM GRAVITY * Quantum Mechanics * Quantum Field Theory * Quantum Gravity * Axionic Instantons * The Small Expansion Parameter * THE AXION MODEL AND THE INSTANTON APPROXIMATION * THE COSMOLOGICAL CONSTANT * The Hawking-Baum Argument * Baby Universes and Coleman's Argument * ACKNOWLEDGEMENTS * REFERENCES

  16. Structure of gamma-ray burst jets: intrinsic versus apparent properties

    NASA Astrophysics Data System (ADS)

    Salafia, O. S.; Ghisellini, G.; Pescalli, A.; Ghirlanda, G.; Nappo, F.

    2015-07-01

    With this paper we introduce the concept of apparent structure of a gamma-ray burst (GRB) jet, as opposed to its intrinsic structure. The latter is customarily defined specifying the functions ɛ(θ) (the energy emitted per jet unit solid angle) and Γ(θ) (the Lorentz factor of the emitting material); the apparent structure is instead defined by us as the isotropic equivalent energy Eiso(θv) as a function of the viewing angle θv. We show how to predict the apparent structure of a jet given its intrinsic structure. We find that a Gaussian intrinsic structure yields a power-law apparent structure: this opens a new viewpoint on the Gaussian (which can be understood as a proxy for a realistic narrow, well-collimated jet structure) as a possible candidate for a quasi-universal GRB jet structure. We show that such a model (a) is consistent with recent constraints on the observed luminosity function of GRBs; (b) implies fewer orphan afterglows with respect to the standard uniform model; (c) can break out the progenitor star (in the collapsar scenario) without wasting an unreasonable amount of energy; (d) is compatible with the explanation of the Amati correlation as a viewing angle effect; (e) can be very standard in energy content, and still yield a very wide range of observed isotropic equivalent energies.

  17. Intrinsic Correlations for Flaring Blazars Detected by Fermi

    NASA Astrophysics Data System (ADS)

    Fan, J. H.; Yang, J. H.; Xiao, H. B.; Lin, C.; Constantin, D.; Luo, G. Y.; Pei, Z. Y.; Hao, J. M.; Mao, Y. W.

    2017-02-01

    Blazars are an extreme subclass of active galactic nuclei. Their rapid variability, luminous brightness, superluminal motion, and high and variable polarization are probably due to a beaming effect. However, this beaming factor (or Doppler factor) is very difficult to measure. Currently, a good way to estimate it is to use the timescale of their radio flares. In this Letter, we use multiwavelength data and Doppler factors reported in the literature for a sample of 86 flaring blazars detected by Fermi to compute their intrinsic multiwavelength data and intrinsic spectral energy distributions and investigate the correlations among observed and intrinsic data. Quite interestingly, intrinsic data show a positive correlation between luminosity and peak frequency, in contrast with the behavior of observed data, and a tighter correlation between γ-ray luminosity and the lower-energy ones. For flaring blazars detected by Fermi, we conclude that (1) observed emissions are strongly beamed; (2) the anti-correlation between luminosity and peak frequency from the observed data is an apparent result, the correlation between intrinsic data being positive; and (3) intrinsic γ-ray luminosity is strongly correlated with other intrinsic luminosities.

  18. Intrinsic coherence in assisted sub-state discrimination

    NASA Astrophysics Data System (ADS)

    Zhang, Fu-Lin; Wang, Teng

    2017-01-01

    We study intrinsic coherence in the tripartite process to unambiguously discriminate two nonorthogonal states of a qubit, entangled with another one, and assisted by an auxiliary system. The optimal success probability is found to be benefited by initial intrinsic coherence, but no extra one is required. The transformations among different contributions of intrinsic coherence are necessary in this procedure, which increase with the overlap between the states to recognize. Such state discrimination is a key step of the probabilistic teleportation protocol. Entanglement of the quantum channel decreases the coherence characterizing the reliance on an ancilla.

  19. Simple intrinsic defects in GaAs : numerical supplement.

    SciTech Connect

    Schultz, Peter Andrew

    2012-04-01

    This Report presents numerical tables summarizing properties of intrinsic defects in gallium arsenide, GaAs, as computed by density functional theory. This Report serves as a numerical supplement to the results published in: P.A. Schultz and O.A. von Lilienfeld, 'Simple intrinsic defects in GaAs', Modelling Simul. Mater. Sci Eng., Vol. 17, 084007 (2009), and intended for use as reference tables for a defect physics package in device models. The numerical results for density functional theory calculations of properties of simple intrinsic defects in gallium arsenide are presented.

  20. Congenital hypertrophy of multiple intrinsic muscles of the foot.

    PubMed

    Shiraishi, Tomohiro; Park, Susam; Niu, Atushi; Hasegawa, Hiromi

    2014-12-01

    Congenital hypertrophy of a single intrinsic muscle of the foot is rare, and as far as we know, only six cases have been reported. We describe a case of congenital anomaly that showed hypertrophy of multiple intrinsic muscles of the foot; the affected muscles were all the intrinsic muscles of the foot except the extensor digitorum brevis or extensor hallucis. Other tissues such as adipose tissue, nervous tissue, or osseous tissue showed no abnormalities. To reduce the volume of the foot we removed parts of the enlarged muscles.

  1. Strength measurements of the intrinsic hand muscles: a review of the development and evaluation of the Rotterdam intrinsic hand myometer.

    PubMed

    Schreuders, Ton A R; Selles, Ruud W; Roebroeck, Marij E; Stam, Henk J

    2006-01-01

    Numerous neurological diseases are accompanied by atrophy of the intrinsic muscles of the hand. Muscle strength testing of these muscles is frequently used for clinical decision making. Traditionally, these strength measurements have focused on manual muscle testing (MMT) or on grip and pinch strength dynamometry. We have developed a hand-held dynamometer, the Rotterdam Intrinsic Hand Myometer (RIHM), to measure this intrinsic muscle strength. The RIHM was designed such that it can measure a wide range of muscle groups, such as the abduction and adduction strength of the little finger and index finger, the opposition, palmar abduction (anteposition) and opposition strength of the thumb, and intrinsic muscles of the fingers combined in the intrinsic plus position. We found that the reliability of RIHM measurements in nerve injury patients was comparable to grip and pinch strength measurements and is appropriate to study the functional recovery of the intrinsic muscles of the hand in isolation. We have applied the RIHM in a recent study on the long-term outcome of muscle strength in patients with ulnar and median nerve injuries and found that while recovery of grip and pinch strength was relatively good, recovery of the ulnar nerve innervated muscles measured with the RIHM was poor. This poor recovery could not be detected with manual muscle strength testing or with grip and pinch dynamometry. We conclude that the RIHM provides an accurate clinical assessment of the muscle strength of the intrinsic hand muscles that adds valuable information to MMT and grip and pinch dynamometry.

  2. Universal Expansion.

    ERIC Educational Resources Information Center

    McArdle, Heather K.

    1997-01-01

    Describes a week-long activity for general to honors-level students that addresses Hubble's law and the universal expansion theory. Uses a discrepant event-type activity to lead up to the abstract principles of the universal expansion theory. (JRH)

  3. Overseas Universities.

    ERIC Educational Resources Information Center

    Inter-University Council for Higher Education Overseas, London (England).

    The following articles and reports are presented in this publication of "Overseas Universities:""Appropriate Technology and University Education," by John Twidell; "The Training of Engineering Staff for Higher Education Institutions in Developing Countries," by D. W. Daniel, C. A. Leal, J. H. Maynes and T. Wilmore;…

  4. University Futures

    ERIC Educational Resources Information Center

    Smith, Richard

    2012-01-01

    Recent radical changes to university education in England have been discussed largely in terms of the arrangements for transferring funding from the state to the student as consumer, with little discussion of what universities are for. It is important, while challenging the economic rationale for the new system, to resist talking about higher…

  5. Innovative Universities.

    ERIC Educational Resources Information Center

    Barsi, Louis M.; Kaebnick, Gweneth W.

    1989-01-01

    The phenomenon of innovation within the university is examined, noting the possibility of innovation as a key to college vitality. A study was conducted using a group of institutions that demonstrated recent innovative spirit. Members of the American Association of State Colleges and Universities (AASCU), each has been recognized in an annual…

  6. Intrinsic and extrinsic motivation for stereotypic and repetitive behavior.

    PubMed

    Joosten, Annette V; Bundy, Anita C; Einfeld, Stewart L

    2009-03-01

    This study provides evidence for intrinsic and extrinsic motivators for stereotypical and repetitive behavior in children with autism and intellectual disability and children with intellectual disability alone. We modified the Motivation Assessment Scale (MAS) (1988b); dividing it into intrinsic and extrinsic measures and adding items to assess anxiety as an intrinsic motivator. Rasch analysis of data from 279 MASs (74 children) revealed that the items formed two unidimensional scales. Anxiety was a more likely intrinsic motivator than sensory seeking for children with dual diagnoses; the reverse was true for children with intellectual disability only. Escape and gaining a tangible object were the most common extrinsic motivators for those with dual diagnoses and attention and escape for children with intellectual disability.

  7. Probability of Intrinsic Time-Arrow from Information Loss

    NASA Astrophysics Data System (ADS)

    Diósi, Lajos

    Time-arrow s=±, intrinsic to a concrete physical system, is associated with the direction of information loss I displayed by the random evolution of the given system. When the information loss tends to zero the intrinsic time-arrow becomes uncertain. We propose the heuristic relationship for the probability of the intrinsic time-arrow. The main parts of the present work are trying to confirm this heuristic equation. The probability of intrinsic time arrow is defined by Bayesian inference from the observed random process. From irreversible thermodynamic systems, the proposed heuristic probabilities follow via the Gallavotti-Cohen relations between time-reversed random processes. In order to explore the underlying microscopic mechanism, a trivial microscopic process is analyzed and an obvious discrepancy is identified. It can be resolved by quantum theory. The corresponding trivial quantum process will exactly confirm the proposed heuristic time-arrow probability.

  8. Unreported intrinsic disorder in proteins: Disorder emergency room

    PubMed Central

    Uversky, Vladimir N

    2015-01-01

    This article continues an “Unreported Intrinsic Disorder in Proteins” series, the goal of which is to expose some interesting cases of missed (or overlooked, or ignored) disorder in proteins. The need for this series is justified by the observation that despite the fact that protein intrinsic disorder is widely accepted by the scientific community, there are still numerous instances when appreciation of this phenomenon is absent. This results in the avalanche of research papers which are talking about intrinsically disordered proteins (or hybrid proteins with ordered and disordered regions) not recognizing that they are talking about such proteins. Articles in the “Unreported Intrinsic Disorder in Proteins” series provide a fast fix for some of the recent noticeable disorder overlooks.

  9. Intrinsic adhesion force of lubricants to steel surface.

    PubMed

    Lee, Jonghwi

    2004-09-01

    The intrinsic adhesion forces of lubricants and other pharmaceutical materials to a steel surface were quantitatively compared using Atomic Force Microscopy (AFM). A steel sphere was attached to the tip of an AFM cantilever, and its adhesion forces to the substrate surfaces of magnesium stearate, sodium stearyl fumarate, lactose, 4-acetamidophenol, and naproxen were measured. Surface roughness varied by an order of magnitude among the materials. However, the results clearly showed that the two lubricants had about half the intrinsic adhesion force as lactose, 4-acetamidophenol, and naproxen. Differences in the intrinsic adhesion forces of the two lubricants were insignificant. The lubricant molecules were unable to cover the steel surface during AFM measurements. Intrinsic adhesion force can slightly be modified by surface treatment and compaction, and its tip-to-tip variation was not greater than its difference between lubricants and other pharmaceutical particles. This study provides a quantitative fundamental basis for understanding adhesion related issues.

  10. Does displayed enthusiasm favour recall, intrinsic motivation and time estimation?

    PubMed

    Moè, Angelica

    2016-11-01

    Displayed enthusiasm has been shown to relate to intrinsic motivation, vitality, and positive affect, but its effects on recall performance and time estimation have not yet been explored. This research aimed at studying the effects of a delivery style characterised by High Enthusiasm (HE) on recall, time estimation, and intrinsic motivation. In line with previous studies, effects on intrinsic motivation were expected. In addition, higher recall and lower time estimations were hypothesised. In two experiments, participants assigned to a HE condition or to a normal reading control condition listened to a narrative and to a descriptive passage. Then, they were asked to rate perceived time, enthusiasm, pleasure, interest, enjoyment and curiosity, before writing a free recall. Experiment 1 showed that in the HE condition, participants recalled more, were more intrinsically motivated, and expressed lower time estimations compared to the control condition. Experiment 2 confirmed the positive effects of HE reading compared to normal reading, using different passages and a larger sample.

  11. Intrinsic feature-based pose measurement for imaging motion compensation

    DOEpatents

    Baba, Justin S.; Goddard, Jr., James Samuel

    2014-08-19

    Systems and methods for generating motion corrected tomographic images are provided. A method includes obtaining first images of a region of interest (ROI) to be imaged and associated with a first time, where the first images are associated with different positions and orientations with respect to the ROI. The method also includes defining an active region in the each of the first images and selecting intrinsic features in each of the first images based on the active region. Second, identifying a portion of the intrinsic features temporally and spatially matching intrinsic features in corresponding ones of second images of the ROI associated with a second time prior to the first time and computing three-dimensional (3D) coordinates for the portion of the intrinsic features. Finally, the method includes computing a relative pose for the first images based on the 3D coordinates.

  12. Evidence that intrinsic iron but not intrinsic copper determines S-nitrosocysteine decomposition in buffer solution.

    PubMed

    Vanin, Anatoly F; Muller, Bernard; Alencar, Jacicarlos L; Lobysheva, Irina I; Nepveu, Françoise; Stoclet, Jean-Claude

    2002-11-01

    The present experiments were designed to analyze the influence of copper and iron ions on the process of decomposition of S-nitrosocysteine (cysNO), the most labile species among S-nitrosothiols (RSNO). CysNO fate in buffer solution was evaluated by optical and electron paramagnetic resonance (EPR) spectroscopy, and the consequences on its vasorelaxant effect were studied on noradrenaline-precontracted rat aortic rings. The main results are the following: (i) copper or iron ions, especially in the presence of the reducing agent ascorbate, accelerated the decomposition of cysNO and markedly attenuated the amplitude and duration of the relaxant effect of cysNO; (ii) by contrast, the iron and copper chelators bathophenantroline disulfonic acid (BPDS) and bathocuproine disulfonic acid (BCS) exerted a stabilizing effect on cysNO, prolonged its vasorelaxant effect, and abolished the influence of ascorbate; (iii) in the presence of ascorbate, BPDS displayed a selective inhibitory effect toward the influence of iron ions (but not toward copper ions) on cysNO decomposition and vasorelaxant effect, while BCS prevented the effects of both copper and iron ions; (iv) L-cysteine enhanced stability and prolonged the relaxant effect of cysNO; (v) the process of iron-induced decomposition of cysNO was associated with the formation of EPR-detectable dinitrosyl-iron complexes (DNIC) either with non-thiol- or thiol-containing ligands (depending on the presence of L-cysteine), both of which exhibiting vasorelaxant properties. From these data, it is concluded that the amount of intrinsic copper was probably too low to produce a destabilizing effect even on the most labile RSNO, cysNO, and that only intrinsic iron, through the formation of DNIC, was responsible for the process of cysNO decomposition and thus influenced its vasorelaxant properties.

  13. Effects of Temperature on the Histotripsy Intrinsic Threshold for Cavitation.

    PubMed

    Vlaisavljevich, Eli; Xu, Zhen; Maxwell, Adam; Mancia, Lauren; Zhang, Xi; Lin, Kuang-Wei; Duryea, Alexander; Sukovich, Jonathan; Hall, Tim; Johnsen, Eric; Cain, Charles

    2016-05-10

    Histotripsy is an ultrasound ablation method that depends on the initiation of a dense cavitation bubble cloud to fractionate soft tissue. Previous work has demonstrated that a cavitation cloud can be formed by a single acoustic pulse with one high amplitude negative cycle, when the negative pressure amplitude exceeds a threshold intrinsic to the medium. The intrinsic thresholds in soft tissues and tissue phantoms that are water-based are similar to the intrinsic threshold of water over an experimentally verified frequency range of 0.3-3 MHz. Previous work studying the histotripsy intrinsic threshold has been limited to experiments performed at room temperature (~20°C). In this study, we investigate the effects of temperature on the histotripsy intrinsic threshold in water, which is essential to accurately predict the intrinsic thresholds expected over the full range of in vivo therapeutic temperatures. Based on previous work studying the histotripsy intrinsic threshold and classical nucleation theory, we hypothesize that the intrinsic threshold will decrease with increasing temperature. To test this hypothesis, the intrinsic threshold in water was investigated both experimentally and theoretically. The probability of generating cavitation bubbles was measured by applying a single pulse with one high amplitude negative cycle at 1 MHz to distilled, degassed water at temperatures ranging from 10°C-90°C. Cavitation was detected and characterized by passive cavitation detection and high-speed photography, from which the probability of cavitation was measured vs. pressure amplitude. The results indicate that the intrinsic threshold (the negative pressure at which the cavitation probability=0.5) significantly decreases with increasing temperature, showing a nearly linear decreasing trend from 29.8±0.4 MPa at 10˚C to 14.9±1.4 MPa at 90˚C. Overall, the results of this study support our hypothesis that the intrinsic threshold is highly dependent upon the temperature

  14. New force field on modeling intrinsically disordered proteins.

    PubMed

    Wang, Wei; Ye, Wei; Jiang, Cheng; Luo, Ray; Chen, Hai-Feng

    2014-09-01

    Intrinsically disordered proteins or intrinsically disordered protein regions comprise a large portion of eukaryotic proteomes (between 35% and 51%). These intrinsically disordered proteins were found to link with cancer and various other diseases. However, widely used additive force field parameter sets are insufficient in quantifying the structural properties of intrinsically disordered proteins. Therefore, we explored to a systematic correction of a base additive force field parameter set (chosen as Amber ff99SBildn) to correct the biases that was first demonstrated in simulations with the base parameter set. Specifically, the φ/ψ distributions of disorder-promoting residues were systematically corrected with the CMAP method. Our simulations show that the CMAP corrected Amber parameter set, termed ff99IDPs, improves the φ/ψ distributions of the disorder-promoting residues with respect to the benchmark data of intrinsically disordered protein structures, with root mean-squared percentage deviation less than 0.15% between the simulation and the benchmark. Our further validation shows that the chemical shifts from the ff99IDPs simulations are in quantitative agreement with those from reported NMR measurements for two tested IDPs, MeV NTAIL , and p53. The predicted residue dipolar couplings also show high correlation with experimental data. Interestingly, our simulations show that ff99IDPs can still be used to model the ordered state when the intrinsically disordered proteins are in complex, in contrast to ff99SBildn that can be applied well only to the ordered complex structures. These findings confirm that the newly proposed Amber ff99IDPs parameter set provides a reasonable tool in further studies of intrinsically disordered protein structures. In addition, our study also shows the importance of considering intrinsically disordered protein structures in general-purposed force field developments for both additive and non-additive models.

  15. Intrinsic optical modulation mechanism in electro-optic crystals

    NASA Astrophysics Data System (ADS)

    Garzarella, A.; Hinton, R. J.; Qadri, S. B.; Wu, Dong Ho

    2008-06-01

    An intrinsic mechanism of optical intensity modulation occurring in electro-optic devices such as field sensors and modulators under applied fields is described. The optical modulation results from interactions between internally generated Fizeau interference patterns and electro-optic effects within the nonlinear crystal. Our results indicate that when phase matched with the conventional polarimetric signal, the intrinsic modulation mechanism can nearly double device sensitivity.

  16. Kinetic Stress and Intrinsic Flow in a Toroidal Plasma

    NASA Astrophysics Data System (ADS)

    Ding, W. X.; Lin, L.; Brower, D. L.; Almagri, A. F.; Chapman, B. E.; Fiksel, G.; Den Hartog, D. J.; Sarff, J. S.

    2013-02-01

    A new mechanism for intrinsic plasma flow has been experimentally identified in a toroidal plasma. For reversed field pinch plasmas with a few percent β (ratio of plasma pressure to magnetic pressure), measurements show that parallel pressure fluctuations correlated with magnetic fluctuations create a kinetic stress that can affect momentum balance and the evolution of intrinsic plasma flow. This implies kinetic effects are important for flow generation and sustainment.

  17. A hierarchy of intrinsic timescales across primate cortex

    PubMed Central

    Murray, John D.; Bernacchia, Alberto; Freedman, David J.; Romo, Ranulfo; Wallis, Jonathan D.; Cai, Xinying; Padoa-Schioppa, Camillo; Pasternak, Tatiana; Seo, Hyojung; Lee, Daeyeol; Wang, Xiao-Jing

    2014-01-01

    Specialization and hierarchy are organizing principles for primate cortex, yet there is little direct evidence for how cortical areas are specialized in the temporal domain. We measured timescales of intrinsic fluctuations in spiking activity across areas, and found a hierarchical ordering, with sensory and prefrontal areas exhibiting shorter and longer timescales, respectively. Based on our findings, we suggest that intrinsic timescales reflect areal specialization for task-relevant computations over multiple temporal ranges. PMID:25383900

  18. Self-perception of intrinsic and extrinsic motivation.

    PubMed

    Calder, B J; Staw, B M

    1975-04-01

    Self-perception theory predicts that intrinsic and extrinsic motivation do not combine additively but rather interact. To test this predicted interaction, intrinsic and extrinsic motivation were both manipulated as independent variables. The results revealed a significant interaction for task satisfaction and a trend for the interaction on a behavioral measure. These results are discussed in terms of a general approach to the self-perception of motivation.

  19. Probing Quasar Winds Using Intrinsic Narrow Absorption Lines

    NASA Astrophysics Data System (ADS)

    Culliton, Christopher S.; Charlton, Jane C.; Eracleous, Michael; Roberts, Amber; Ganguly, Rajib; Misawa, Toru; Muzahid, Sowgat

    2017-01-01

    Quasar outflows are important for understanding the accretion and growth processes of the central black hole. Furthermore, outflows potentially have a role in providing feedback to the galaxy, and halting star formation and infall of gas. The geometry and density of these outflows remain unknown, especially as a function of ionization and velocity. Having searched ultraviolet spectra at both high redshift (VLT/UVES; 1.4intrinsic to (physically associated with) the quasar. We identify intrinsic NALs with a wide range of properties, including ejection velocity, coverage fraction, and ionization level. We also consider the incidence of intrinsic absorbers as a function of quasar properties (optical, radio and X-ray fluxes), and find that radio properties and quasar orientation are influential in determining if a quasar is likely to host an intrinsic system. We find that there is a continuum of properties within the intrinsic NAL sample, rather than discrete families, ranging from partially covered CIV systems with black Lya and with a separate low ionization gas phase to partially covered NV systems with partially covered Lya and without detected low ionization gas. Additionally, we construct a model describing the spatial distributions, geometries, and varied ionization structures of intrinsic NALs.

  20. Intrinsically Disordered Side of the Zika Virus Proteome

    PubMed Central

    Giri, Rajanish; Kumar, Deepak; Sharma, Nitin; Uversky, Vladimir N.

    2016-01-01

    Over the last few decades, concepts of protein intrinsic disorder have been implicated in different biological processes. Recent studies have suggested that intrinsically disordered proteins (IDPs) provide structural plasticity and functional diversity to viral proteins that are involved in rapid replication and immune evasion in host cells. In case of Zika virus, the roles of protein intrinsic disorder in mechanisms of pathogenesis are not completely understood. In this study, we have analyzed the prevalence of intrinsic disorder in Zika virus proteome (strain MR 766). Our analyses revealed that Zika virus polyprotein is enriched with intrinsically disordered protein regions (IDPRs) and this finding is consistent with previous reports on the involvement of IDPs in shell formation and virulence of the Flaviviridae family. We found abundant IDPRs in Capsid, NS2B, NS3, NS4A, and NS5 proteins that are involved in mature particle formation and replication. In our view, the intrinsic disorder-focused analysis of ZIKV proteins could be important for the development of disorder-based drugs. PMID:27867910

  1. Intrinsic honesty and the prevalence of rule violations across societies.

    PubMed

    Gächter, Simon; Schulz, Jonathan F

    2016-03-24

    Deception is common in nature and humans are no exception. Modern societies have created institutions to control cheating, but many situations remain where only intrinsic honesty keeps people from cheating and violating rules. Psychological, sociological and economic theories suggest causal pathways to explain how the prevalence of rule violations in people's social environment, such as corruption, tax evasion or political fraud, can compromise individual intrinsic honesty. Here we present cross-societal experiments from 23 countries around the world that demonstrate a robust link between the prevalence of rule violations and intrinsic honesty. We developed an index of the 'prevalence of rule violations' (PRV) based on country-level data from the year 2003 of corruption, tax evasion and fraudulent politics. We measured intrinsic honesty in an anonymous die-rolling experiment. We conducted the experiments with 2,568 young participants (students) who, due to their young age in 2003, could not have influenced PRV in 2003. We find individual intrinsic honesty is stronger in the subject pools of low PRV countries than those of high PRV countries. The details of lying patterns support psychological theories of honesty. The results are consistent with theories of the cultural co-evolution of institutions and values, and show that weak institutions and cultural legacies that generate rule violations not only have direct adverse economic consequences, but might also impair individual intrinsic honesty that is crucial for the smooth functioning of society.

  2. Intrinsic Honesty and the Prevalence of Rule Violations across Societies

    PubMed Central

    Gächter, Simon; Schulz, Jonathan F.

    2016-01-01

    Deception is common in nature and humans are no exception1. Modern societies have created institutions to control cheating, but many situations remain where only intrinsic honesty keeps people from cheating and violating rules. Psychological2, sociological3 and economic theories4 suggest causal pathways about how the prevalence of rule violations in people's social environment such as corruption, tax evasion, or political fraud can compromise individual intrinsic honesty. Here, we present cross-societal experiments from 23 countries around the world, which demonstrate a robust link between the prevalence of rule violations and intrinsic honesty. We developed an index of the Prevalence of Rule Violations (PRV) based on country-level data of corruption, tax evasion, and fraudulent politics. We measured intrinsic honesty in an anonymous die-rolling experiment.5 We conducted the experiments at least eight years after the measurement of PRV with 2568 young participants (students) who could not influence PRV. We find individual intrinsic honesty is stronger in the subject pools of low PRV countries than those of high PRV countries. The details of lying patterns support psychological theories of honesty.6,7 The results are consistent with theories of the cultural co-evolution of institutions and values8 and show that weak institutions and cultural legacies9-11 that generate rule violations not only have direct adverse economic consequences but might also impair individual intrinsic honesty that is crucial for the smooth functioning of society. PMID:26958830

  3. Universe Awareness

    NASA Astrophysics Data System (ADS)

    Sankatsing Nava, Tibisay; Russo, Pedro

    2015-08-01

    Universe Awareness (UNAWE) is an educational programme coordinated by Leiden University that uses the beauty and grandeur of the Universe to encourage young children, particularly those from an underprivileged background, to have an interest in science and technology and foster their sense of global citizenship from the earliest age.UNAWE's twofold vision uses our Universe to inspire and motivate very young children: the excitement of the Universe provides an exciting introduction to science and technology, while the vastness and beauty of the Universe helps broaden the mind and stimulate a sense of global citizenship and tolerance. UNAWE's goals are accomplished through four main activities: the coordination of a global network of more than 1000 astronomers, teachers and educators from more than 60 countries, development of educational resources, teacher training activities and evaluation of educational activities.Between 2011 and 2013, EU-UNAWE, the European branch of UNAWE, was funded by the European Commission to implement a project in 5 EU countries and South Africa. This project has been concluded successfully. Since then, the global project Universe Awareness has continued to grow with an expanding international network, new educational resources and teacher trainings and a planned International Workshop in collaboration with ESA in October 2015, among other activities.

  4. Universal Memcomputing Machines.

    PubMed

    Traversa, Fabio Lorenzo; Di Ventra, Massimiliano

    2015-11-01

    We introduce the notion of universal memcomputing machines (UMMs): a class of brain-inspired general-purpose computing machines based on systems with memory, whereby processing and storing of information occur on the same physical location. We analytically prove that the memory properties of UMMs endow them with universal computing power (they are Turing-complete), intrinsic parallelism, functional polymorphism, and information overhead, namely, their collective states can support exponential data compression directly in memory. We also demonstrate that a UMM has the same computational power as a nondeterministic Turing machine, namely, it can solve nondeterministic polynomial (NP)-complete problems in polynomial time. However, by virtue of its information overhead, a UMM needs only an amount of memory cells (memprocessors) that grows polynomially with the problem size. As an example, we provide the polynomial-time solution of the subset-sum problem and a simple hardware implementation of the same. Even though these results do not prove the statement NP = P within the Turing paradigm, the practical realization of these UMMs would represent a paradigm shift from the present von Neumann architectures, bringing us closer to brain-like neural computation.

  5. Universal Truths.

    ERIC Educational Resources Information Center

    Horgan, John

    1990-01-01

    Described is a symposium of Nobel laureates held in the summer of 1990 to discuss cosmology. Different views on the structure and evolution of the universe are presented. Evidence for different theories of cosmology is discussed. (CW)

  6. Majestic Universe

    NASA Astrophysics Data System (ADS)

    Brunier, Serge; Dunlop, Storm

    1999-10-01

    Foreword; 1. The history of cosmology; 2. The galaxy, an island in space; 3. A thousand generations of stars; 4. The next supernova; 5. Planets by the billion?; 6. The enigma at the heart of the Milky Way; 7. A sea of galaxies; 8. The architecture of the universe; 9. The Big Bang, and the history of the universe; 10. Gravitational lenses; 11. The mystery of the missing mass; 12. Searching for the ultimate; 13. Towards the cosmological horizon; Appendices; Glossary; Index; Bibliography.

  7. Undulant Universe

    SciTech Connect

    Barenboim, Gabriela; Mena, Olga; Quigg, Chris; /Fermilab

    2004-12-01

    If the equation of state for ''dark energy'' varies periodically, the expansion of the Universe may have undergone alternating eras of acceleration and deceleration. We examine a specific form that survives existing observational tests, does not single out the present state of the Universe as exceptional, and suggests a future much like the matter-dominated past: a smooth expansion without a final inflationary epoch.

  8. An intrinsic timer specifies distal structures of the vertebrate limb

    PubMed Central

    Saiz-Lopez, Patricia; Chinnaiya, Kavitha; Campa, Victor M.; Delgado, Irene; Ros, Maria A.; Towers, Matthew

    2015-01-01

    How the positional values along the proximo-distal axis (stylopod-zeugopod-autopod) of the limb are specified is intensely debated. Early work suggested that cells intrinsically change their proximo-distal positional values by measuring time. Recently, however, it is suggested that instructive extrinsic signals from the trunk and apical ectodermal ridge specify the stylopod and zeugopod/autopod, respectively. Here, we show that the zeugopod and autopod are specified by an intrinsic timing mechanism. By grafting green fluorescent protein-expressing cells from early to late chick wing buds, we demonstrate that distal mesenchyme cells intrinsically time Hoxa13 expression, cell cycle parameters and the duration of the overlying apical ectodermal ridge. In addition, we reveal that cell affinities intrinsically change in the distal mesenchyme, which we suggest results in a gradient of positional values along the proximo-distal axis. We propose a complete model in which a switch from extrinsic signalling to intrinsic timing patterns the vertebrate limb. PMID:26381580

  9. Generation disrupts memory for intrinsic context but not extrinsic context.

    PubMed

    Mulligan, Neil W

    2011-08-01

    Although generation typically enhances item memory, the effect is subject to a number of theoretically important limitations. One potential limitation concerns context memory but there has been debate about whether generation actually enhances or disrupts memory for contextual details. Five experiments assessed the effect of generation on context memory for perceptual attributes of the study stimulus (intrinsic context). The results indicate that despite enhancing item memory, generation disrupts memory for intrinsic context. This result generalized over different intrinsic details (print colour and font), different generation manipulations, and several methodological factors identified in earlier research as potential moderators of this negative generation effect. Despite the negative generation effect on intrinsic context, contextual details external to the target item (extrinsic context) are not disrupted. In a sixth experiment, a visually based generation task (letter transposition) enhanced context memory for the extrinsic detail of location. Coupled with earlier research, the results indicate that generation disrupts context memory for intrinsic details but either does not harm or enhances memory for extrinsic context.

  10. Intrinsic periodic and aperiodic stochastic resonance in an electrochemical cell

    NASA Astrophysics Data System (ADS)

    Tiwari, Ishant; Phogat, Richa; Parmananda, P.; Ocampo-Espindola, J. L.; Rivera, M.

    2016-08-01

    In this paper we show the interaction of a composite of a periodic or aperiodic signal and intrinsic electrochemical noise with the nonlinear dynamics of an electrochemical cell configured to study the corrosion of iron in an acidic media. The anodic voltage setpoint (V0) in the cell is chosen such that the anodic current (I ) exhibits excitable fixed point behavior in the absence of noise. The subthreshold periodic (aperiodic) signal consists of a train of rectangular pulses with a fixed amplitude and width, separated by regular (irregular) time intervals. The irregular time intervals chosen are of deterministic and stochastic origins. The amplitude of the intrinsic internal noise, regulated by the concentration of chloride ions, is then monotonically increased, and the provoked dynamics are analyzed. The signal to noise ratio and the cross-correlation coefficient versus the chloride ions' concentration curves have a unimodal shape indicating the emergence of an intrinsic periodic or aperiodic stochastic resonance. The abscissa for the maxima of these unimodal curves correspond to the optimum value of intrinsic noise where maximum regularity of the invoked dynamics is observed. In the particular case of the intrinsic periodic stochastic resonance, the scanning electron microscope images for the electrode metal surfaces are shown for certain values of chloride ions' concentrations. These images, qualitatively, corroborate the emergence of order as a result of the interaction between the nonlinear dynamics and the composite signal.

  11. Semisupervised Support Vector Machines With Tangent Space Intrinsic Manifold Regularization.

    PubMed

    Sun, Shiliang; Xie, Xijiong

    2016-09-01

    Semisupervised learning has been an active research topic in machine learning and data mining. One main reason is that labeling examples is expensive and time-consuming, while there are large numbers of unlabeled examples available in many practical problems. So far, Laplacian regularization has been widely used in semisupervised learning. In this paper, we propose a new regularization method called tangent space intrinsic manifold regularization. It is intrinsic to data manifold and favors linear functions on the manifold. Fundamental elements involved in the formulation of the regularization are local tangent space representations, which are estimated by local principal component analysis, and the connections that relate adjacent tangent spaces. Simultaneously, we explore its application to semisupervised classification and propose two new learning algorithms called tangent space intrinsic manifold regularized support vector machines (TiSVMs) and tangent space intrinsic manifold regularized twin SVMs (TiTSVMs). They effectively integrate the tangent space intrinsic manifold regularization consideration. The optimization of TiSVMs can be solved by a standard quadratic programming, while the optimization of TiTSVMs can be solved by a pair of standard quadratic programmings. The experimental results of semisupervised classification problems show the effectiveness of the proposed semisupervised learning algorithms.

  12. Photovoltaic device comprising compositionally graded intrinsic photoactive layer

    DOEpatents

    Hoffbauer, Mark A; Williamson, Todd L

    2013-04-30

    Photovoltaic devices and methods of making photovoltaic devices comprising at least one compositionally graded photoactive layer, said method comprising providing a substrate; growing onto the substrate a uniform intrinsic photoactive layer having one surface disposed upon the substrate and an opposing second surface, said intrinsic photoactive layer consisting essentially of In.sub.1-xA.sub.xN,; wherein: i. 0.ltoreq.x.ltoreq.1; ii. A is gallium, aluminum, or combinations thereof; and iii. x is at least 0 on one surface of the intrinsic photoactive layer and is compositionally graded throughout the layer to reach a value of 1 or less on the opposing second surface of the layer; wherein said intrinsic photoactive layer is isothermally grown by means of energetic neutral atom beam lithography and epitaxy at a temperature of 600.degree. C. or less using neutral nitrogen atoms having a kinetic energy of from about 1.0 eV to about 5.0 eV, and wherein the intrinsic photoactive layer is grown at a rate of from about 5 nm/min to about 100 nm/min.

  13. Intrinsic bioremediation modeling to support Superfund site closure

    SciTech Connect

    Bedard, A.H.; Day, M.J.; Johnson, R.H.; Ritter, K.J.; Stancel, S.G.; Thomson, J.A.M.

    1997-09-01

    Closure of the groundwater component of a major Superfund site has been accomplished by a combination of source control, engineered in-situ bioremediation, and subsequent long-term intrinsic bioremediation. Engineered bioremediation outside the source control area resulted in very significant contaminant mass removal. This allowed intrinsic bioremediation to be considered as a passive remedial management method of achieving cleanup objectives after active remediation needed. Modeling demonstrated that intrinsic bioremediation would achieve cleanup objectives (for this site, Federal drinking water standards) within ten years of shutdown of the active bioremediation system. Modeling showed that residual electron acceptors and nutrients distributed in the aquifer during engineered bioremediation greatly enhance the intrinsic bioremediation process. The results of the modeling effort led to the active system being shut down a year ahead of schedule, allowing the project to move into a low-maintenance intrinsic bioremediation and long-term monitoring phase. The modeling demonstration coupled Visual MODFLOW{copyright} and BioTrans{copyright} to simulate groundwater flow, solute transport, and oxygen-limited, multi-species biodegradation. Regional flow evaluation, detailed model sensitivity analyses, and subarea modeling were employed to provide support to model predictions. Predictions will be tested by subsequent progress and compliance monitoring. Site closure began in early 1996.

  14. Scalability, Timing, and System Design Issues for Intrinsic Evolvable Hardware

    NASA Technical Reports Server (NTRS)

    Hereford, James; Gwaltney, David

    2004-01-01

    In this paper we address several issues pertinent to intrinsic evolvable hardware (EHW). The first issue is scalability; namely, how the design space scales as the programming string for the programmable device gets longer. We develop a model for population size and the number of generations as a function of the programming string length, L, and show that the number of circuit evaluations is an O(L2) process. We compare our model to several successful intrinsic EHW experiments and discuss the many implications of our model. The second issue that we address is the timing of intrinsic EHW experiments. We show that the processing time is a small part of the overall time to derive or evolve a circuit and that major improvements in processor speed alone will have only a minimal impact on improving the scalability of intrinsic EHW. The third issue we consider is the system-level design of intrinsic EHW experiments. We review what other researchers have done to break the scalability barrier and contend that the type of reconfigurable platform and the evolutionary algorithm are tied together and impose limits on each other.

  15. Turbulent-driven intrinsic rotation in tokamak plasmas

    NASA Astrophysics Data System (ADS)

    Barnes, Michael; Parra, Felix; Lee, Jungpyo; Belli, Emily; Nave, Filomena; White, Anne

    2013-10-01

    Tokamak plasmas are routinely observed to rotate even in the absence of an externally applied torque. This ``intrinsic'' rotation exhibits several robust features, including rotation reversals with varying plasma density and current and rotation peaking at the transition from low confinement to high confinement regimes. Conservation of toroidal angular momentum dictates that the intrinsic rotation is determined by momentum redistribution within the plasma, which is dominated by turbulent transport. The turbulent momentum transport, and thus the intrinsic rotation profile, is driven by formally small effects that are usually neglected. We present a gyrokinetic theory that makes use of the smallness of the poloidal to total magnetic field ratio to self-consistently include the dominant effects driving intrinsic turbulent momentum transport in tokamaks. These effects (including slow radial profile variation, slow poloidal turbulence variation, and diamagnetic corrections to the equilibrium Maxwellian) have now been implemented in the local, delta-f gyrokinetic code GS2. We describe important features of the numerical implementation and show numerical results on intrinsic momentum transport that are qualitatively consistent with experimental rotation reversals.

  16. Physics of Intrinsic Rotation in Flux-Driven ITG Turbulence

    SciTech Connect

    Ku, S; Dimond, P H; Dif-Pradalier, G; Kwon, J M; Sarazin, Y; Hahm, T S; Garbet, X; Chang, C S; Latu, G; Yoon, E S; Ghendrih, Ph; Yi, S; Strugarek, A; Solomon, W

    2012-02-23

    Global, heat flux-driven ITG gyrokinetic simulations which manifest the formation of macroscopic, mean toroidal flow profiles with peak thermal Mach number 0.05, are reported. Both a particle-in-cell (XGC1p) and a semi-Lagrangian (GYSELA) approach are utilized without a priori assumptions of scale-separation between turbulence and mean fields. Flux-driven ITG simulations with different edge flow boundary conditions show in both approaches the development of net unidirectional intrinsic rotation in the co-current direction. Intrinsic torque is shown to scale approximately linearly with the inverse scale length of the ion temperature gradient. External momentum input is shown to effectively cancel the intrinsic rotation profile, thus confirming the existence of a local residual stress and intrinsic torque. Fluctuation intensity, intrinsic torque and mean flow are demonstrated to develop inwards from the boundary. The measured correlations between residual stress and two fluctuation spectrum symmetry breakers, namely E x B shear and intensity gradient, are similar. Avalanches of (positive) heat flux, which propagate either outwards or inwards, are correlated with avalanches of (negative) parallel momentum flux, so that outward transport of heat and inward transport of parallel momentum are correlated and mediated by avalanches. The probability distribution functions of the outward heat flux and the inward momentum flux show strong structural similarity

  17. Intrinsic motivation and amotivation in first episode and prolonged psychosis.

    PubMed

    Luther, Lauren; Lysaker, Paul H; Firmin, Ruth L; Breier, Alan; Vohs, Jenifer L

    2015-12-01

    The deleterious functional implications of motivation deficits in psychosis have generated interest in examining dimensions of the construct. However, there remains a paucity of data regarding whether dimensions of motivation differ over the course of psychosis. Therefore, this study examined two motivation dimensions, trait-like intrinsic motivation, and the negative symptom of amotivation, and tested the impact of illness phase on the 1) levels of these dimensions and 2) relationship between these dimensions. Participants with first episode psychosis (FEP; n=40) and prolonged psychosis (n=66) completed clinician-rated measures of intrinsic motivation and amotivation. Analyses revealed that when controlling for group differences in gender and education, the FEP group had significantly more intrinsic motivation and lower amotivation than the prolonged psychosis group. Moreover, intrinsic motivation was negatively correlated with amotivation in both FEP and prolonged psychosis, but the magnitude of the relationship did not statistically differ between groups. These findings suggest that motivation deficits are more severe later in the course of psychosis and that low intrinsic motivation may be partially independent of amotivation in both first episode and prolonged psychosis. Clinically, these results highlight the importance of targeting motivation in early intervention services.

  18. Cosmological information in the intrinsic alignments of luminous red galaxies

    SciTech Connect

    Chisari, Nora Elisa; Dvorkin, Cora E-mail: cdvorkin@ias.edu

    2013-12-01

    The intrinsic alignments of galaxies are usually regarded as a contaminant to weak gravitational lensing observables. The alignment of Luminous Red Galaxies, detected unambiguously in observations from the Sloan Digital Sky Survey, can be reproduced by the linear tidal alignment model of Catelan, Kamionkowski and Blandford (2001) on large scales. In this work, we explore the cosmological information encoded in the intrinsic alignments of red galaxies. We make forecasts for the ability of current and future spectroscopic surveys to constrain local primordial non-Gaussianity and Baryon Acoustic Oscillations (BAO) in the cross-correlation function of intrinsic alignments and the galaxy density field. For the Baryon Oscillation Spectroscopic Survey, we find that the BAO signal in the intrinsic alignments is marginally significant with a signal-to-noise ratio of 1.8 and 2.2 with the current LOWZ and CMASS samples of galaxies, respectively, and increasing to 2.3 and 2.7 once the survey is completed. For the Dark Energy Spectroscopic Instrument and for a spectroscopic survey following the EUCLID redshift selection function, we find signal-to-noise ratios of 12 and 15, respectively. Local type primordial non-Gaussianity, parametrized by f{sub NL} = 10, is only marginally significant in the intrinsic alignments signal with signal-to-noise ratios < 2 for the three surveys considered.

  19. Intrinsically restless: Unifying science, writing, and the human condition

    NASA Astrophysics Data System (ADS)

    Sissom, Matthew

    The field of physics has always fascinated me, but I never possessed the mathematical skills necessary to extend that interest past the point of curiosity. This thesis was set up to explore how I and other writers, specifically Walt Whitman, use(d) the skills we do have to ask and attempt to answer the same cosmic questions normally reserved for scientists overseeing particle collider experiments. In Tao of Physics, Fritjof Capra attempted to blend the principles of Eastern philosophy with the movements associated with modern physics. In doing so, he offers up a few insights into the human desire to "divide the world into separate objects and events" (117), which I believe, when it comes to fiction, greatly influences the audience's interpretive framework. Capra suggests, "To believe that our abstract concepts of separate `things' and `vents' are realities of nature is an illusion" (117). Humans use this division to cope with our everyday environment, yet it is not a fundamental feature of reality but, rather, an abstraction devised by our discriminating and categorizing intellect. It is a coping mechanism, as Capra refers to it, that pins writers in a corner, encouraging them to forms and styles set by their predecessors to better satisfy the "discriminating and categorizing intellect" of their audience. Writers often struggle to achieve a balance between accurately presenting the human condition that, like Capra's description of subatomic particles as "intrinsically restless" (117), changes based on myriad variables and properly structuring their writing to fit a predetermined model. Whitman, a fan of popular science, drew from the scientific world, using his understanding of the interpretive framework, to better craft his poems' metaphors. In "Song of Myself," Whitman suggests that the celebration of one's own existence cannot be separated from the celebration of the universe, "For every atom belonging to me as good belongs to you" (1-3). Whitman's writing

  20. Plasma universe

    NASA Technical Reports Server (NTRS)

    Alfven, H.

    1986-01-01

    Traditionally the views on the cosmic environent have been based on observations in the visual octave of the electromagnetic spectrum, during the last half-century supplemented by infrared and radio observations. Space research has opened the full spectrum. Of special importance are the X-ray-gamma-ray regions, in which a number of unexpected phenomena have been discovered. Radiations in these regions are likely to originate mainly from magnetised cosmic plasmas. Such a medium may also emit synchrotron radiation which is observable in the radio region. If a model of the universe is based on the plasma phenomena mentioned it is found that the plasma universe is drastically different from the traditional visual universe. Information about the plasma universe can also be obtained by extrapolation of laboratory experiments and magnetospheric in situ measurements of plasmas. This approach is possible because it is likely that the basic properties of plasmas are the same everywhere. In order to test the usefulness of the plasma universe model it is applied to cosmogony. Such an approach seems to be rather successful. For example, the complicated structure of the Saturnian C ring can be accounted for. It is possible to reconstruct certain phenomena 4 to 5 billions of years ago with an accuracy of better than 1%.

  1. Linear Magnetization Dependence of the Intrinsic Anomalous Hall Effect

    SciTech Connect

    Zeng, C.; Yao, Y.; Niu, Q.; Weitering, Harm H

    2006-01-01

    The anomalous Hall effect is investigated experimentally and theoretically for ferromagnetic thin films of Mn{sub 5}Ge{sub 3}. We have separated the intrinsic and extrinsic contributions to the experimental anomalous Hall effect and calculated the intrinsic anomalous Hall conductivity from the Berry curvature of the Bloch states using first-principles methods. The intrinsic anomalous Hall conductivity depends linearly on the magnetization, which can be understood from the long-wavelength fluctuations of the spin orientation at finite temperatures. The quantitative agreement between theory and experiment is remarkably good, not only near 0 K but also at finite temperatures, up to about -240 K (0.8T{sub c}).

  2. Exploration of Horizontal Intrinsic Spin Resonances in the AGS

    NASA Astrophysics Data System (ADS)

    Lin, Fanglei; Lee, S. Y.; Ahrens, Leif A.; Bai, Mei; Brown, Kevin; Courant, Ernest D.; Glenn, Joseph W.; Huang, Haixin; Luccio, Alfredo; Mackay, William W.; Ptitsyn, Vadim; Roser, Thomas; Tepikian, Steven; Tsoupas, Nicholaos; Wood, Jeff; Yip, Yin; Okamura, Masahiro; Takano, Junpei

    2006-04-01

    Siberian snakes have been employed to overcome spin resonances during polarized proton acceleration. Considering limited space in the AGS, strong partial snakes that rotate the spin by less than 180 degrees can be used to avoid the spin imperfection and intrinsic resonances in low energy accelerators. However, the tilt of spin away from the vertical direction may become sensitive to horizontal betatron motion which can also cause spin depolarization. These resonances, called horizontal intrinsic spin resonances, have been observed in simulations. Preliminary measurements with beam were also carried out in AGS 2005 polarized proton run. During the AGS 2006 run, we plan to explore the details about the horizontal intrinsics resonances further. This paper describes the experimental methods and the latest results.

  3. Chimpanzees and bonobos differ in intrinsic motivation for tool use.

    PubMed

    Koops, Kathelijne; Furuichi, Takeshi; Hashimoto, Chie

    2015-06-16

    Tool use in nonhuman apes can help identify the conditions that drove the extraordinary expansion of hominin technology. Chimpanzees and bonobos are our closest living relatives. Whereas chimpanzees are renowned for their tool use, bonobos use few tools and none in foraging. We investigated whether extrinsic (ecological and social opportunities) or intrinsic (predispositions) differences explain this contrast by comparing chimpanzees at Kalinzu (Uganda) and bonobos at Wamba (DRC). We assessed ecological opportunities based on availability of resources requiring tool use. We examined potential opportunities for social learning in immature apes. Lastly, we investigated predispositions by measuring object manipulation and object play. Extrinsic opportunities did not explain the tool use difference, whereas intrinsic predispositions did. Chimpanzees manipulated and played more with objects than bonobos, despite similar levels of solitary and social play. Selection for increased intrinsic motivation to manipulate objects likely also played an important role in the evolution of hominin tool use.

  4. Extrinsic and intrinsic motivation at 30: Unresolved scientific issues.

    PubMed

    Reiss, Steven

    2005-01-01

    The undermining effect of extrinsic reward on intrinsic motivation remains unproven. The key unresolved issues are construct invalidity (all four definitions are unproved and two are illogical); measurement unreliability (the free-choice measure requires unreliable, subjective judgments to infer intrinsic motivation); inadequate experimental controls (negative affect and novelty, not cognitive evaluation, may explain "undermining" effects); and biased metareviews (studies with possible floor effects excluded, but those with possible ceiling effects included). Perhaps the greatest error with the undermining theory, however, is that it does not adequately recognize the multifaceted nature of intrinsic motivation (Reiss, 2004a). Advice to limit the use of applied behavior analysis based on "hidden" undermining effects is ideologically inspired and is unsupported by credible scientific evidence.

  5. Molecular Recognition by Templated Folding of an Intrinsically Disordered Protein

    NASA Astrophysics Data System (ADS)

    Toto, Angelo; Camilloni, Carlo; Giri, Rajanish; Brunori, Maurizio; Vendruscolo, Michele; Gianni, Stefano

    2016-02-01

    Intrinsically disordered proteins often become structured upon interacting with their partners. The mechanism of this ‘folding upon binding’ process, however, has not been fully characterised yet. Here we present a study of the folding of the intrinsically disordered transactivation domain of c-Myb (c-Myb) upon binding its partner KIX. By determining the structure of the folding transition state for the binding of wild-type and three mutational variants of KIX, we found a remarkable plasticity of the folding pathway of c-Myb. To explain this phenomenon, we show that the folding of c-Myb is templated by the structure of KIX. This adaptive folding behaviour, which occurs by heterogeneous nucleation, differs from the robust homogeneous nucleation typically observed for globular proteins. We suggest that this templated folding mechanism may enable intrinsically disordered proteins to achieve specific and reliable binding with multiple partners while avoiding aberrant interactions.

  6. Airborne sodium lidar measurements of gravity wave intrinsic parameters

    NASA Astrophysics Data System (ADS)

    Kwon, Kang H.; Gardner, Chester S.

    1990-11-01

    A data analysis technique for determining gravity wave intrinsic parameters including wave propagation direction is described. The technique involves measuring the altitude variations of the wave-induced density perturbations of the atmospheric Na layer. This technique can be used with airborne lidars, multiple ground-based lidars, and steerable lidars. In this paper the technique is applied to airborne Na lidar data obtained during a round-trip flight from Denver, Colorado, to the Pacific Coast in November 1986. During the flight, strong wave perturbations were observed in the Na layer near the Pacific coast over a horizontal distance of nearly 700 km. The intrinsic horizontal wavelength of this wave was estimated to be about 85 km, and the vertical wavelength was 4.1 km. The intrinsic period was about 102 min, and the propagation direction was almost due south.

  7. The effects of cooperative and individualistic reward on intrinsic motivation.

    PubMed

    Hom, H L; Berger, M; Duncan, M K; Miller, A; Blevin, A

    1994-03-01

    The effects of cooperative versus individualistic reward on students' intrinsic motivation were investigated. The controlling aspects of extrinsic reward may be heightened or produce greater ego threat in the individualistic situation when compared with a group situation. We predicted that students in the cooperative social situation would show higher levels of intrinsic motivation. Fifth-grade students from existing cooperative groups were assigned randomly to receive a tangible reward based on either cooperative or individualistic achievement for completing pattern block designs. Cooperation affected intrinsic motivation positively. Students in the cooperative dyad solved the block designs more quickly, interacted positively, and viewed the task as easier than did those in the individualistic situation, and they reported that their peers were helpful. There was little evidence that the controlling functions of reward or ego-threat were factors in producing the outcome. Some evidence supporting the importance of the social nature of cooperation was provided.

  8. [Intrinsic ureteral endometriosis: description of a striking instance].

    PubMed

    Antonelli, Alessandro; Finotto, Elena; Zambolin, Tiziano; Fisogni, Simona; Simeone, Claudio

    2015-01-01

    Intrinsic ureteral endometriosis is a very rare condition. A 41 y. o. woman with right hydroureteronephrosis and other aspecific symptoms came to our attention. The CT scan showed an ureteral obstacle causing the hydroureteronephrosis. She underwent ureterorenoscopy with biopsies of the lesion that did not result to be diriment. Suspecting a ureteral neoplasm, the patient then underwent ureteral resection and ureterocystoneostomy, and the extemporary histological examination resulted as endometriosis. The abdominal exploration showed a parametrial and a peritoneal growth - both compatible with the extemporary histological examination - that were also excised. The post-operative course was uneventful. The definitive hystological examination confirmed the perioperatory diagnosis. Intrinsic ureteral endometriosis is confirmed as a rare pathology with an indefinite clinical presentation; its typical presentation, namely cyclic hematuria, seems to be an anecdotal feature. Therefore the diagnostics of intrinsic ureteral endometriosis is still difficult even despite such a striking presentation.

  9. Transport and MHD simulations of intrinsic and pellet induced ELMs

    NASA Astrophysics Data System (ADS)

    Kim, Ki Min; Na, Yong-Su; Yi, Sumin; Kim, Hyunseok; Kim, Jin Yong

    2010-11-01

    Verification of ELM mechanism and demonstration of ELM control are important issues in current fusion researches targeting ITER and DEMO. This work investigates the physics and operational characteristics of intrinsic and pellet induced ELMs throughout transport simulations using 1.5 D transport codes (C1.5/ASTRA) and MHD simulations using M3D code. Transport simulations are focused on prediction of the global parameters such as ELM energy loss in the type-I ELMy H-mode discharges with and without pellet pace making to examine an applicability of pellet injection for ELM mitigation in KSTAR and ITER. On the other hand, MHD simulations are conducted to explore the physics of intrinsic and pellet induced ELMs by applying the artificial free energy sources of velocity stream and density perturbations on the marginally stable equilibrium, respectively. Similarities and differences of triggering phenomena between intrinsic and pellet induced ELMs are discussed from the MHD approach.

  10. Molecular Recognition by Templated Folding of an Intrinsically Disordered Protein

    PubMed Central

    Toto, Angelo; Camilloni, Carlo; Giri, Rajanish; Brunori, Maurizio; Vendruscolo, Michele; Gianni, Stefano

    2016-01-01

    Intrinsically disordered proteins often become structured upon interacting with their partners. The mechanism of this ‘folding upon binding’ process, however, has not been fully characterised yet. Here we present a study of the folding of the intrinsically disordered transactivation domain of c-Myb (c-Myb) upon binding its partner KIX. By determining the structure of the folding transition state for the binding of wild-type and three mutational variants of KIX, we found a remarkable plasticity of the folding pathway of c-Myb. To explain this phenomenon, we show that the folding of c-Myb is templated by the structure of KIX. This adaptive folding behaviour, which occurs by heterogeneous nucleation, differs from the robust homogeneous nucleation typically observed for globular proteins. We suggest that this templated folding mechanism may enable intrinsically disordered proteins to achieve specific and reliable binding with multiple partners while avoiding aberrant interactions. PMID:26912067

  11. Correspondence between evoked and intrinsic functional brain network configurations.

    PubMed

    Bolt, Taylor; Nomi, Jason S; Rubinov, Mikail; Uddin, Lucina Q

    2017-04-01

    Much of the literature exploring differences between intrinsic and task-evoked brain architectures has examined changes in functional connectivity patterns between specific brain regions. While informative, this approach overlooks important overall functional changes in hub organization and network topology that may provide insights about differences in integration between intrinsic and task-evoked states. Examination of changes in overall network organization, such as a change in the concentration of hub nodes or a quantitative change in network organization, is important for understanding the underlying processes that differ between intrinsic and task-evoked brain architectures. The present study used graph-theoretical techniques applied to publicly available neuroimaging data collected from a large sample of individuals (N = 202), and a within-subject design where resting-state and several task scans were collected from each participant as part of the Human Connectome Project. We demonstrate that differences between intrinsic and task-evoked brain networks are characterized by a task-general shift in high-connectivity hubs from primarily sensorimotor/auditory processing areas during the intrinsic state to executive control/salience network areas during task performance. In addition, we demonstrate that differences between intrinsic and task-evoked architectures are associated with changes in overall network organization, such as increases in network clustering, global efficiency and integration between modules. These findings offer a new perspective on the principles guiding functional brain organization by identifying unique and divergent properties of overall network organization between the resting-state and task performance. Hum Brain Mapp 38:1992-2007, 2017. © 2017 Wiley Periodicals, Inc.

  12. Quantum Universe

    NASA Astrophysics Data System (ADS)

    Mukhanov, V. F.

    2016-10-01

    In March 2013, following an accurate processing of available measurement data, the Planck Scientific Collaboration published the highest-resolution photograph ever of the early Universe when it was only a few hundred thousand years old. The photograph showed galactic seeds in sufficient detail to test some nontrivial theoretical predictions made more than thirty years ago. Most amazing was that all predictions were confirmed to be remarkably accurate. With no exaggeration, we may consider it established experimentally that quantum physics, which is normally assumed to be relevant on the atomic and subatomic scale, also works on the scale of the entire Universe, determining its structure with all its galaxies, stars, and planets.

  13. Thermal limit to the intrinsic emittance from metal photocathodes

    SciTech Connect

    Feng, Jun Nasiatka, J.; Wan, Weishi; Karkare, Siddharth; Padmore, Howard A.; Smedley, John

    2015-09-28

    Measurements of the intrinsic emittance and transverse momentum distributions obtained from a metal (antimony thin film) photocathode near and below the photoemission threshold are presented. Measurements show that the intrinsic emittance is limited by the lattice temperature of the cathode as the incident photon energy approaches the photoemission threshold. A theoretical model to calculate the transverse momentum distributions near this photoemission threshold is presented. An excellent match between the experimental measurements and the theoretical calculations is demonstrated. These measurements are relevant to low emittance electron sources for Free Electron Lasers and Ultrafast Electron Diffraction experiments.

  14. Intrinsic instability of aberration-corrected electron microscopes.

    PubMed

    Schramm, S M; van der Molen, S J; Tromp, R M

    2012-10-19

    Aberration-corrected microscopes with subatomic resolution will impact broad areas of science and technology. However, the experimentally observed lifetime of the corrected state is just a few minutes. Here we show that the corrected state is intrinsically unstable; the higher its quality, the more unstable it is. Analyzing the contrast transfer function near optimum correction, we define an "instability budget" which allows a rational trade-off between resolution and stability. Unless control systems are developed to overcome these challenges, intrinsic instability poses a fundamental limit to the resolution practically achievable in the electron microscope.

  15. Intrinsic defect formation in peptide self-assembly

    NASA Astrophysics Data System (ADS)

    Deng, Li; Zhao, Yurong; Xu, Hai; Wang, Yanting

    2015-07-01

    In contrast to extensively studied defects in traditional materials, we report here a systematic investigation of the formation mechanism of intrinsic defects in self-assembled peptide nanostructures. The Monte Carlo simulations with our simplified dynamic hierarchical model revealed that the symmetry breaking of layer bending mode at the two ends during morphological transformation is responsible for intrinsic defect formation, whose microscopic origin is the mismatch between layer stacking along the side-chain direction and layer growth along the hydrogen bond direction. Moreover, defect formation does not affect the chirality of the self-assembled structure, which is determined by the initial steps of the peptide self-assembly process.

  16. Tolerance of Intrinsic Defects in PbS Quantum Dots.

    PubMed

    Zherebetskyy, Danylo; Zhang, Yingjie; Salmeron, Miquel; Wang, Lin-Wang

    2015-12-03

    Colloidal quantum dots exhibit various defects and deviations from ideal structures due to kinetic processes, although their band gap frequently remains open and clean. In this Letter, we computationally investigate intrinsic defects in a real-size PbS quantum dot passivated with realistic Cl-ligands. We show that the colloidal intrinsic defects are ionic in nature. Unlike previous computational results, we find that even nonideal, atomically nonstoichiometric quantum dots have a clean band gap without in-gap-states provided that quantum dots satisfy electronic stoichiometry.

  17. Intrinsic integrated UBVRI colors of Galactic globular clusters

    NASA Technical Reports Server (NTRS)

    Reed, B. Cameron; Hesser, James E.; Shawl, Stephen J.

    1988-01-01

    Published observational data on 50 Galactic globular clusters, including spectral classifications, homogenized colors, and color excesses, are compiled in extensive tables, graphs, and diagrams and analyzed to determine the intrinsic-color/integrated-spectral-type relationship in the UBVRI system. These relationships are found to exhibit significant slopes, although the RI colors do not contribute substantially to the intrinsic-color determination. The values of a(B-V) for the northern and southern Galactic hemispheres are found to be 0.068 + or - 0.006 and 0.039 + or - 0.003 mag, respectively.

  18. Failure to label baboon milk intrinsically with iron

    SciTech Connect

    Figueroa-Colon, R.; Elwell, J.H.; Jackson, E.; Osborne, J.W.; Fomon, S.J. )

    1989-11-01

    The widely held belief that 50% of the iron in human milk is absorbed is based on studies that have used an extrinsic radioactive iron tag. To determine the validity of an extrinsic tag, it is necessary to label the milk intrinsically with one isotope and to compare absorption of this isotope with absorption of another isotope added as the extrinsic tag. We chose the baboon as a model and infused 59Fe intravenously. In each of three attempts we failed to label the milk intrinsically.

  19. Extrinsic and intrinsic S stars in the Henize sample

    NASA Astrophysics Data System (ADS)

    Van Eck, Sophie; Jorissen, Alain; Mayor, Michel; Udry, Stephane; Burnet, Michel

    Previous studies have identified two distinct families among S stars: intrinsic S stars exhibiting Tc lines in their spectrum, and extrinsic S stars lacking Tc lines. Extrinsic S stars were found to be binaries, and probably owe their chemical peculiarities to mass transfer in the binary system. On the contrary, intrinsic S stars are thermally-pulsating AGB stars where the third dredge-up brought heavy elements to the surface. The Henize sample of 205 S stars south of declination -25^circ is especially well suited for inferring the relative frequency of extrinsic/intrinsic S stars, since it is not biased towards low galactic latitudes where intrinsic S stars tend to concentrate. Each star has been measured 3 or 4 times over a period of 5 years with the spectrovelocimeter CORAVEL. The search for binaries is complicated by the fact that Mira-type pulsations are frequent among intrinsic S stars. Fortunately, radial-velocity variations due to atmospheric motions are generally associated with very broad and asymmetric CORAVEL cross-correlation profiles [see also poster P2-14!]. Therefore extrinsic and intrinsic S stars can be distinguished thanks to (1) radial velocity variations, (2) the shape of the CORAVEL cross-correlation profiles, (3) the presence or absence of the radioactive element Tc, as derived from high-resolution spectroscopy, (4) photometric variability, as derived from a survey in the Geneva photometric system. These criteria correlate in a nice way and allow to derive the frequency of intrinsic-genuine AGB-S stars. The galactic distributions of the two families of S stars are clearly distinct, intrinsic S stars being much more concentrated along the galactic plane that extrinsic S stars. High-resolution spectroscopy led to the discovery of two symbiotic stars among the Henize sample (symbiotic stars are interacting binary systems in which a hot compact object accretes matter ejected by a cool (super)giant). The physical parameters responsible for the

  20. Intrinsic Defects and H Doping in WO3

    PubMed Central

    Zhu, Jiajie; Vasilopoulou, Maria; Davazoglou, Dimitris; Kennou, Stella; Chroneos, Alexander; Schwingenschlögl, Udo

    2017-01-01

    WO3 is widely used as industrial catalyst. Intrinsic and/or extrinsic defects can tune the electronic properties and extend applications to gas sensors and optoelectonics. However, H doping is a challenge to WO3, the relevant mechanisms being hardly understood. In this context, we investigate intrinsic defects and H doping by density functional theory and experiments. Formation energies are calculated to determine the lowest energy defect states. O vacancies turn out to be stable in O-poor environment, in agreement with X-ray photoelectron spectroscopy, and O-H bond formation of H interstitial defects is predicted and confirmed by Fourier transform infrared spectroscopy. PMID:28098210

  1. Intrinsic Defects and H Doping in WO3

    NASA Astrophysics Data System (ADS)

    Zhu, Jiajie; Vasilopoulou, Maria; Davazoglou, Dimitris; Kennou, Stella; Chroneos, Alexander; Schwingenschlögl, Udo

    2017-01-01

    WO3 is widely used as industrial catalyst. Intrinsic and/or extrinsic defects can tune the electronic properties and extend applications to gas sensors and optoelectonics. However, H doping is a challenge to WO3, the relevant mechanisms being hardly understood. In this context, we investigate intrinsic defects and H doping by density functional theory and experiments. Formation energies are calculated to determine the lowest energy defect states. O vacancies turn out to be stable in O-poor environment, in agreement with X-ray photoelectron spectroscopy, and O-H bond formation of H interstitial defects is predicted and confirmed by Fourier transform infrared spectroscopy.

  2. Finding intrinsic rewards by embodied evolution and constrained reinforcement learning.

    PubMed

    Uchibe, Eiji; Doya, Kenji

    2008-12-01

    Understanding the design principle of reward functions is a substantial challenge both in artificial intelligence and neuroscience. Successful acquisition of a task usually requires not only rewards for goals, but also for intermediate states to promote effective exploration. This paper proposes a method for designing 'intrinsic' rewards of autonomous agents by combining constrained policy gradient reinforcement learning and embodied evolution. To validate the method, we use Cyber Rodent robots, in which collision avoidance, recharging from battery packs, and 'mating' by software reproduction are three major 'extrinsic' rewards. We show in hardware experiments that the robots can find appropriate 'intrinsic' rewards for the vision of battery packs and other robots to promote approach behaviors.

  3. Intrinsic Instability of Aberration-Corrected Electron Microscopes

    NASA Astrophysics Data System (ADS)

    Schramm, S. M.; van der Molen, S. J.; Tromp, R. M.

    2012-10-01

    Aberration-corrected microscopes with subatomic resolution will impact broad areas of science and technology. However, the experimentally observed lifetime of the corrected state is just a few minutes. Here we show that the corrected state is intrinsically unstable; the higher its quality, the more unstable it is. Analyzing the contrast transfer function near optimum correction, we define an “instability budget” which allows a rational trade-off between resolution and stability. Unless control systems are developed to overcome these challenges, intrinsic instability poses a fundamental limit to the resolution practically achievable in the electron microscope.

  4. Changes in Intrinsic Motivation as a Function of Negative Feedback and Threats.

    ERIC Educational Resources Information Center

    Deci, Edward L.; Cascio, Wayne F.

    Recent studies have demonstrated that external rewards can affect intrinsic motivation to perform an activity. Money tends to decrease intrinsic motivation, whereas positive verbal reinforcements tend to increase intrinsic motivation. This paper presents evidence that negative feedback and threats of punishment also decrease intrinsic motivation.…

  5. Minute Time Scale Prolyl Isomerization Governs Antibody Recognition of an Intrinsically Disordered Immunodominant Epitope*

    PubMed Central

    Fassolari, Marisol; Chemes, Lucia B.; Gallo, Mariana; Smal, Clara; Sánchez, Ignacio E.; de Prat-Gay, Gonzalo

    2013-01-01

    Conformational rearrangements in antibody·antigen recognition are essential events where kinetic discrimination of isomers expands the universe of combinations. We investigated the interaction mechanism of a monoclonal antibody, M1, raised against E7 from human papillomavirus, a prototypic viral oncoprotein and a model intrinsically disordered protein. The mapped 12-amino acid immunodominant epitope lies within a “hinge” region between the N-terminal intrinsically disordered and the C-terminal globular domains. Kinetic experiments show that despite being within an intrinsically disordered region, the hinge E7 epitope has at least two populations separated by a high energy barrier. Nuclear magnetic resonance traced the origin of this barrier to a very slow (t½ ∼4 min) trans-cis prolyl isomerization event involving changes in secondary structure. The less populated (10%) cis isomer is the binding-competent species, thus requiring the 90% of molecules in the trans configuration to isomerize before binding. The association rate for the cis isomer approaches 6 × 107 m−1 s−1, a ceiling for antigen-antibody interactions. Mutagenesis experiments showed that Pro-41 in E7Ep was required for both binding and isomerization. After a slow postbinding unimolecular rearrangement, a consolidated complex with KD = 1.2 × 10−7 m is reached. Our results suggest that presentation of this viral epitope by the antigen-presenting cells would have to be “locked” in the cis conformation, in opposition to the most populated trans isomer, in order to select the specific antibody clone that goes through affinity and kinetic maturation. PMID:23504368

  6. Universities 2035

    ERIC Educational Resources Information Center

    Thrift, Nigel

    2016-01-01

    This paper examines the future of Western higher education. Situated midway between an analysis and a polemic, it concerns itself with how we might begin to actively design the universities of the future. That will require a productionist account of higher education which is so far sadly lacking. But there are signs that such an account might be…

  7. University Productivity

    ERIC Educational Resources Information Center

    Sommers, Alexis N.

    1977-01-01

    Academic communities are under intense pressures to balance expenditures with income. Strategies are offered here to increase productivity drawn from the experiences of the University of New Haven. Emphasis is on revenue-cost ratios, class size, and faculty teaching schedules as primary factors in productivity improvement. (Editor/LBH)

  8. New Universities

    ERIC Educational Resources Information Center

    Burgett, Bruce

    2011-01-01

    The public-private alliance signals a future in which self-serving agreements could become the coin of the realm. Such a future would be a betrayal of the historical promise of public universities to innovate in ways that expand access to higher education. Given the rise of market-based models in educational policy circles, the threat of the…

  9. University Builders.

    ERIC Educational Resources Information Center

    Pearce, Martin

    This publication explores a diverse collection of new university buildings. Ranging from the design of vast new campuses, such as that by Wilford and Stirling at Temasek, Singapore, through to the relatively modest yet strategically important, such as the intervention by Allies and Morrison at Southampton, this book examines the new higher…

  10. [Medical professionals on the subject of their core values: the importance of practice-based stories and intrinsic motivation].

    PubMed

    Witman, Yolande; van den Kerkhof, Peter C M; Braat, Didi D M

    2013-01-01

    In the current system for guaranteeing quality of care, emphasis is placed firmly on external control of professionals. We looked for a way to appeal to the intrinsic motivation of medical professionals and to discover what they mean by 'good work'. This was achieved with the aid of reflective sessions using the toolkit 'Good Work': in four sessions three different groups of medical professionals (medical department chairs, residents and interns) from a Dutch university hospital reflected on the topics 'excellence', 'moral responsibility' and 'personal engagement'. The participants exchanged practice-based stories during the sessions. The most important theme was moral responsibility, with its accompanying dilemmas. The sessions gave rise to feelings of mutual acknowledgement, recognition, inspiration and motivation. Sharing meaningful practice-based stories can be considered as a 'moment of learning', strengthening professional identity and stimulating intrinsic motivation. More space for this form of reflection might restore the balance with external control systems.

  11. Intrinsic bond strength of metal films on polymer substrates

    NASA Technical Reports Server (NTRS)

    Wheeler, Donald R.; Osaki, Hiroyuki

    1990-01-01

    A semiquantitative method for the measurement of the intrinsic bond strength between elastic substrates and elastic films that fail by brittle fracture is described. Measurements on a polyethylene terephthalate (PET)-Ni couple were used to verify the essential features of the analysis. It was found that the interfacial shear strength of Ni on PET doubled after ion etching.

  12. How Information Affects Intrinsic Motivation: Two Exploratory Pilot Studies.

    ERIC Educational Resources Information Center

    Small, Ruth V.; Samijo

    Research on the motivational aspects of multimedia games may provide ways to design more engaging user information systems which increase users' exploratory and information-seeking behaviors. Two small-scale exploratory studies examined the effects of introducing information on the intrinsic motivation of users of a CD-ROM game. Results of the…

  13. Playwriting Pedagogy and the Myth of Intrinsic Creativity

    ERIC Educational Resources Information Center

    Gardiner, Paul

    2016-01-01

    Debates surrounding the teaching of playwriting are heavily influenced by theories of creativity. This article reports on research in Australian secondary schools that explored the student and teacher experiences of playwriting pedagogy. The findings of the research revealed that teaching was based on a belief in intrinsic creativity: that…

  14. Searching for Variability of NV Intrinsic Narrow Absorption Line Systems

    NASA Astrophysics Data System (ADS)

    Rodruck, Michael; Charlton, Jane C.; Ganguly, Rajib

    2017-01-01

    The majority of quasar absorption line systems with NV detected are found within the associated region (within 5000km/s of the quasar redshift) and many/most are believed to be related to the quasar accretion disk wind or outflows. The most definite evidence that these NV absorbers are "intrinsic" is partial covering of the quasar continuum source and/or broad line region. Over 50 quasars containing NV narrow absorption lines have observations obtained at different times with the Keck/HIRES and the VLT/UVES spectrographs at high resolution. The interval between these observations range from months to a decade in the quasar rest frame. While variability is common for intrinsic broad and mini-broad absorption lines, intrinsic narrow absorption lines have been found to be less likely to vary, though systematic studies with large, high quality datasets have been limited. The variability timescales are useful for deriving gas densities and thus the distances from the central engines. This is important in mapping the quasar surroundings, understanding the accretion disk wind mechanism, and assessing the effect the wind has on the galaxy surroundings. We report on the results of a systematic study of variability of NV NALs, exploiting the overlap of targets for observations in the archives of Keck and VLT, and discuss the consequences for interpretation of the origin of intrinsic narrow absorption lines.

  15. The intrinsic disorder alphabet. III. Dual personality of serine

    PubMed Central

    Uversky, Vladimir N

    2015-01-01

    Proteins are natural polypeptides consisting of 20 major amino acid residues, content and order of which in a given amino acid sequence defines the ability of a related protein to fold into unique functional state or to stay intrinsically disordered. Amino acid sequences code for both foldable (ordered) proteins/domains and for intrinsically disordered proteins (IDPs) and IDP regions (IDPRs), but these sequence codes are dramatically different. This difference starts with a very general property of the corresponding amino acid sequences, namely, their compositions. IDPs/IDPRs are enriched in specific disorder-promoting residues, whereas amino acid sequences of ordered proteins/domains typically contain more order-promoting residues. Therefore, the relative abundances of various amino acids in ordered and disordered proteins can be used to scale amino acids according to their disorder promoting potentials. This review continues a series of publications on the roles of different amino acids in defining the phenomenon of protein intrinsic disorder and represents serine, which is the third most disorder-promoting residue. Similar to previous publications, this review represents some physico-chemical properties of serine and the roles of this residue in structures and functions of ordered proteins, describes major posttranslational modifications tailored to serine, and finally gives an overview of roles of serine in structure and functions of intrinsically disordered proteins. PMID:28232888

  16. Ethnic Stigma, Academic Anxiety, and Intrinsic Motivation in Middle Childhood

    ERIC Educational Resources Information Center

    Gillen-O'Neel, Cari; Ruble, Diane N.; Fuligni, Andrew J.

    2011-01-01

    Previous research addressing the dynamics of stigma and academics has focused on African American adolescents and adults. The present study examined stigma awareness, academic anxiety, and intrinsic motivation among 451 young (ages 6-11) and diverse (African American, Chinese, Dominican, Russian, and European American) students. Results indicated…

  17. Element Interactivity and Intrinsic, Extraneous, and Germane Cognitive Load

    ERIC Educational Resources Information Center

    Sweller, John

    2010-01-01

    In cognitive load theory, element interactivity has been used as the basic, defining mechanism of intrinsic cognitive load for many years. In this article, it is suggested that element interactivity underlies extraneous cognitive load as well. By defining extraneous cognitive load in terms of element interactivity, a distinct relation between…

  18. The Effects of Extrinsic Reinforcement on Intrinsic Motivation.

    ERIC Educational Resources Information Center

    Blocker, Richard A.; Edwards, R. P.

    1982-01-01

    Discusses the role of extrinsic reinforcement in intrinsic motivation in cognitive attribution theory. Concludes that cognitive attribution theory lacks parsimony, in that extant reinforcement analysis can account for undermining with equal facility. Suggests undermining is of little significance due to its elusive and transient impact on operant…

  19. An Overview of Student Teachers' Academic Intrinsic Motivation

    ERIC Educational Resources Information Center

    Uyulgan, Melis Arzu; Akkuzu, Nalan

    2014-01-01

    Student teachers' desire to learn is affected by a variety of motivational factors. In this study, the effect of some internal and external variables on Academic Intrinsic Motivation (AIM) was explored. First, the validity and reliability of the scale of AIM was determined, then the effect on AIM of variables such as grade levels, academic grade…

  20. The restless brain: how intrinsic activity organizes brain function.

    PubMed

    Raichle, Marcus E

    2015-05-19

    Traditionally studies of brain function have focused on task-evoked responses. By their very nature such experiments tacitly encourage a reflexive view of brain function. While such an approach has been remarkably productive at all levels of neuroscience, it ignores the alternative possibility that brain functions are mainly intrinsic and ongoing, involving information processing for interpreting, responding to and predicting environmental demands. I suggest that the latter view best captures the essence of brain function, a position that accords well with the allocation of the brain's energy resources, its limited access to sensory information and a dynamic, intrinsic functional organization. The nature of this intrinsic activity, which exhibits a surprising level of organization with dimensions of both space and time, is revealed in the ongoing activity of the brain and its metabolism. As we look to the future, understanding the nature of this intrinsic activity will require integrating knowledge from cognitive and systems neuroscience with cellular and molecular neuroscience where ion channels, receptors, components of signal transduction and metabolic pathways are all in a constant state of flux. The reward for doing so will be a much better understanding of human behaviour in health and disease.

  1. Effects of Formative Feedback on Intrinsic Motivation: Examining Ethnic Differences

    ERIC Educational Resources Information Center

    El, Ron Pat; Tillema, Harm; van Koppen, Sabine W. M.

    2012-01-01

    In this study we investigate the influence of ethnic differences on student motivation when learning from formative feedback. Interpersonal teacher behavior and student motivational needs are used to explain the effects of assessment for learning on intrinsic motivation by comparing students from different ethnic backgrounds. The final study's…

  2. The restless brain: how intrinsic activity organizes brain function

    PubMed Central

    Raichle, Marcus E.

    2015-01-01

    Traditionally studies of brain function have focused on task-evoked responses. By their very nature such experiments tacitly encourage a reflexive view of brain function. While such an approach has been remarkably productive at all levels of neuroscience, it ignores the alternative possibility that brain functions are mainly intrinsic and ongoing, involving information processing for interpreting, responding to and predicting environmental demands. I suggest that the latter view best captures the essence of brain function, a position that accords well with the allocation of the brain's energy resources, its limited access to sensory information and a dynamic, intrinsic functional organization. The nature of this intrinsic activity, which exhibits a surprising level of organization with dimensions of both space and time, is revealed in the ongoing activity of the brain and its metabolism. As we look to the future, understanding the nature of this intrinsic activity will require integrating knowledge from cognitive and systems neuroscience with cellular and molecular neuroscience where ion channels, receptors, components of signal transduction and metabolic pathways are all in a constant state of flux. The reward for doing so will be a much better understanding of human behaviour in health and disease. PMID:25823869

  3. Museums, Adventures, Discovery Activities: Gifted Curriculum Intrinsically Differentiated.

    ERIC Educational Resources Information Center

    Haensly, Patricia A.

    This paper discusses how museums, adventure programs, and discovery activities can become an intrinsically differentiated gifted curriculum for gifted learners. Museums and adventure programs are a forum for meaningful learning activities. The contextual characteristics of effectively designed settings for learning activities can, if the…

  4. The Intrinsic Value of Archive and Library Material.

    ERIC Educational Resources Information Center

    Menne-Haritz, Angelika; Brubach, Nils

    2000-01-01

    Discusses the intrinsic value of archive and library materials based on a project conducted by the Marburg Archive School (West Germany) to develop criteria for selecting holdings. Topics include external formal features of archive and library materials; conversion methods, including microfilming, imaging, digitization, and textual conversion;…

  5. A GUIDE TO PREPARING INTRINSICALLY PROGRAMED INSTRUCTIONAL MATERIAL.

    ERIC Educational Resources Information Center

    CROWDER, N.; WALTHER, R.E.

    TO AID THOSE RESPONSIBLE FOR THE PREPARATION OF INTRINSICALLY PROGRAMED INSTRUCTIONAL MATERIALS, THE PROCEDURES AND TECHNIQUES DEVELOPED BY THE EDUCATIONAL SCIENCE DIVISION OF U.S. INDUSTRIES, INC., HAVE HERE BEEN ORGANIZED INTO A PRACTICAL WORKING GUIDE. THE ORGANIZATION OF THIS REPORT CLOSELY FOLLOWS THE SEQUENCE OF STEPS REQUIRED TO PRODUCE AN…

  6. Dominance dynamics of competition between intrinsic and extrinsic grouping cues.

    PubMed

    Luna, Dolores; Villalba-García, Cristina; Montoro, Pedro R; Hinojosa, José A

    2016-10-01

    In the present study we examined the dominance dynamics of perceptual grouping cues. We used a paradigm in which participants selectively attended to perceptual groups based on several grouping cues in different blocks of trials. In each block, single and competing grouping cues were presented under different exposure durations (50, 150 or 350ms). Using this procedure, intrinsic vs. intrinsic cues (i.e. proximity and shape similarity) were compared in Experiment 1; extrinsic vs. extrinsic cues (i.e. common region and connectedness) in Experiment 2; and intrinsic vs. extrinsic cues (i.e. common region and shape similarity) in Experiment 3. The results showed that in Experiment 1, no dominance of any grouping cue was found: shape similarity and proximity grouping cues showed similar reaction times (RTs) and interference effects. In contrast, in Experiments 2 and 3, common region dominated processing: (i) RTs to common region were shorter than those to connectedness (Exp. 2) or shape similarity (Exp. 3); and (ii) when the grouping cues competed, common region interfered with connectedness (Exp. 2) and shape similarity (Exp. 3) more than vice versa. The results showed that the exposure duration of stimuli only affected the connectedness grouping cue. An important result of our experiments indicates that when two grouping cues compete, both the non-attended intrinsic cue in Experiment 1, and the non-dominant extrinsic cue in Experiments 2 and 3, are still perceived and they are not completely lost.

  7. Nonperturbative analytical approximate solutions in intrinsically nonlinear systems

    NASA Astrophysics Data System (ADS)

    Kindall, Kevin Gaylynn

    The basis for obtaining analytical approximations in this dissertation is a new nonperturbative iterative approach that preserves the intrinsic nonlinearity of the system. The traditional method for approaching nonlinear equations has been the small amplitude approximation of classical perturbation theory. However, it is becoming increasingly evident that intrinsic nonlinearity or persistence of the interaction is a primary feature of the solutions for the nonlinear equations that have been solved. Although perturbation theory may be useful in certain physical domains, it is a domain which excludes the effects of the persistent interaction, since perturbation theory nullifies any intrinsically nonlinear property. The method of solution used here proceeds by analogy to the well-known result that second order, linear ordinary differential equations can be transformed to a Riccati equation by a change in dependent variable. An analogous transformation for nonlinear partial differential equations leads to a set of integro- differential equations for which the basic structure is Riccati. Approximations are introduced in the integral part of the integro-differential equation which allow for systematic iteration while making no expansion in powers of the coupling constant. Two sets of differential equations are examined: the Maxwell-Bloch set and the Rossler set. The importance of the former lies in its importance to the phenomenon of optical bistability. The latter represents the minimal set necessary to display chaos. In each case, their intrinsic nonlinearity is demonstrated, and nonperturbative approximate solutions are constructed.

  8. Intrinsic Hysteresis Loops Calculation of BZT Thin Films

    NASA Astrophysics Data System (ADS)

    Hikam, M.; Adnan, S. R.

    2014-04-01

    The Landau Devonshire (LK) simulation is utilized to calculate the intrinsic hysteresis properties of Barium Zirconium Titanate (BZT) doped by Indium and Lanthanum. A Delphi program run on Windows platform is used to facilitate the calculation. The simulation is very useful to calculate and understand the Gibbs free energy and the relationship between spontaneous polarization and electric field.

  9. OVERCOMING INTRINSIC AND COUPLING SPIN RESONANCES IN THE AGS.

    SciTech Connect

    BAI,M.AHRENS,L.ROSER,T.

    2002-11-06

    In the Brookhaven AGS, polarized protons are accelerated from G{sub {gamma}} = 4.5 to G{sub {gamma}} = 46.5. During the acceleration, a total of 42 imperfection spin depolarization resonances and 7 intrinsic spin resonances are crossed. Currently, the depolarization at each imperfection spin resonance is overcome by a solenoid 5% snake and full spin flips are induced at 4 out of the 7 intrinsic resonances by the AGS rf dipole to avoid the polarization loss. No correction schemes are applied at the remaining 3 weak spin resonances. In addition, coupling spin resonances are also observed due to the solenoidal field of the snake and no correction is applied for these spin resonances other than keeping the horizontal and vertical betatron tunes separated. In order to achieve {ge} 50% beam polarization out of AGS, all of those spin resonances need to be corrected. This paper proposes three correction methods to overcome the. strong intrinsic spin resonances as well as the weak intrinsic spin resonances and the coupling spin resonances.

  10. Learning "Number Sense" through Digital Games with Intrinsic Feedback

    ERIC Educational Resources Information Center

    Laurillard, Diana

    2016-01-01

    The paper proposes a new interdisciplinary approach to helping low attaining learners in basic mathematics. It reports on the research-informed design and user testing of an adaptive digital game based on constructionist tasks with intrinsic feedback. The approach uses findings from the neuroscience of dyscalculia, cognitive science research on…

  11. Paradoxes and wonders of intrinsic disorder: Complexity of simplicity

    PubMed Central

    Uversky, Vladimir N.

    2016-01-01

    ABSTRACT At first glance it may seem that intrinsically disordered proteins (IDPs) and IDP regions (IDPRs) are simpler than ordered proteins and domains on multiple levels. However, such multilevel simplicity equips these proteins with the ability to have very complex behavior.

  12. Trapped Electron Mode Turbulence Driven Intrinsic Rotation in Tokamak Plasmas

    SciTech Connect

    Wang, W. X.; Hahm, T. S.; Ethier, S.; Zakharov, L. E.

    2011-02-07

    Recent progress from global gyrokinetic simulations in understanding the origin of intrinsic rotation in toroidal plasmas is reported with emphasis on electron thermal transport dominated regimes. The turbulence driven intrinsic torque associated with nonlinear residual stress generation by the fluctuation intensity and the intensity gradient in the presence of zonal flow shear induced asymmetry in the parallel wavenumber spectrum is shown to scale close to linearly with plasma gradients and the inverse of the plasma current. These results qualitatively reproduce empirical scalings of intrinsic rotation observed in various experiments. The origin of current scaling is found to be due to enhanced kll symmetry breaking induced by the increased radial variation of the safety factor as the current decreases. The physics origin for the linear dependence of intrinsic torque on pressure gradient is that both turbulence intensity and the zonal flow shear, which are two key ingredients for driving residual stress, increase with the strength of turbulence drive, which is R0/LTe and R0/Lne for the trapped electron mode. __________________________________________________

  13. Human phoneme recognition depending on speech-intrinsic variability.

    PubMed

    Meyer, Bernd T; Jürgens, Tim; Wesker, Thorsten; Brand, Thomas; Kollmeier, Birger

    2010-11-01

    The influence of different sources of speech-intrinsic variation (speaking rate, effort, style and dialect or accent) on human speech perception was investigated. In listening experiments with 16 listeners, confusions of consonant-vowel-consonant (CVC) and vowel-consonant-vowel (VCV) sounds in speech-weighted noise were analyzed. Experiments were based on the OLLO logatome speech database, which was designed for a man-machine comparison. It contains utterances spoken by 50 speakers from five dialect/accent regions and covers several intrinsic variations. By comparing results depending on intrinsic and extrinsic variations (i.e., different levels of masking noise), the degradation induced by variabilities can be expressed in terms of the SNR. The spectral level distance between the respective speech segment and the long-term spectrum of the masking noise was found to be a good predictor for recognition rates, while phoneme confusions were influenced by the distance to spectrally close phonemes. An analysis based on transmitted information of articulatory features showed that voicing and manner of articulation are comparatively robust cues in the presence of intrinsic variations, whereas the coding of place is more degraded. The database and detailed results have been made available for comparisons between human speech recognition (HSR) and automatic speech recognizers (ASR).

  14. Extrinsic Rewards and Intrinsic Motivation in Education: Reconsidered Once Again.

    ERIC Educational Resources Information Center

    Deci, Edward L.; Koestner, Richard; Ryan, Richard M.

    2001-01-01

    Reviews the results of a meta analysis (E. Deci, R. Koestner, and R. Ryan, 1999) that shows that tangible extrinsic rewards do have a substantial undermining effect on intrinsic motivation. Discusses results, which support cognitive evaluation theory, in terms of their relevance for educational practice. (SLD)

  15. Improving Secondary School Students' Achievement using Intrinsic Motivation

    ERIC Educational Resources Information Center

    Albrecht, Erik; Haapanen, Rebecca; Hall, Erin; Mantonya, Michelle

    2009-01-01

    This report describes a program for increasing students' intrinsic motivation in an effort to increase academic achievement. The targeted population consisted of secondary level students in a middle to upper-middle class suburban area. The students of the targeted secondary level classes appeared to be disengaged from learning due to a lack of…

  16. Teacher and Student Intrinsic Motivation in Project-Based Learning

    ERIC Educational Resources Information Center

    Lam, Shui-fong; Cheng, Rebecca Wing-yi; Ma, William Y. K.

    2009-01-01

    In this study we examined the relationship between teacher and student intrinsic motivation in project-based learning. The participants were 126 Hong Kong secondary school teachers and their 631 students who completed evaluation questionnaires after a semester-long project-based learning program. Both teachers and students were asked to indicate…

  17. The Role of Teacher Behavior in Adolescents' Intrinsic Reading Motivation

    ERIC Educational Resources Information Center

    De Naeghel, Jessie; Valcke, Martin; De Meyer, Inge; Warlop, Nele; van Braak, Johan; Van Keer, Hilde

    2014-01-01

    Given the weak intrinsic reading motivation of many adolescents on the one hand and the importance of this type of motivation for reading competence on the other hand, the aim of the present study is to identify the related role of teacher behavior. To pursue this aim, a secondary analysis was carried out on PISA 2009 data. More particularly, data…

  18. Associations of personality with intrinsic motivation in schizophrenia.

    PubMed

    Vohs, Jenifer L; Lysaker, Paul H; Nabors, Lori

    2013-06-30

    Motivation is often disturbed in patients with schizophrenia, but little is known about how it relates to personality. We examined intrinsic motivation (IM), two personality domains from the NEO Five-Factor Inventory, and symptoms in 58 male patients with schizophrenia spectrum disorders. Analyses revealed IM may be linked to Extraversion, Neuroticism, and negative symptoms.

  19. Learning-by-Teaching: Designing Teachable Agents with Intrinsic Motivation

    ERIC Educational Resources Information Center

    Zhao, Guopeng; Ailiya; Shen, Zhiqi

    2012-01-01

    Teachable agent is a type of pedagogical agent which instantiates Learning-by-Teaching theory through simulating a "naive" learner in order to motivate students to teach it. This paper discusses the limitation of existing teachable agents and incorporates intrinsic motivation to the agent model to enable teachable agents with initiative…

  20. Transport of Intrinsic Plutonium Colloids in Saturated Porous Media

    NASA Astrophysics Data System (ADS)

    Zhou, D.; Abdel-Fattah, A.; Boukhalfa, H.; Ware, S. D.; Tarimala, S.; Keller, A. A.

    2011-12-01

    Actinide contaminants were introduced to the subsurface environment as a result of nuclear weapons development and testing, as well as for nuclear power generation and related research activities for defense and civilian applications. Even though most actinide species were believed to be fairly immobile once in the subsurface, recent studies have shown the transport of actinides kilometers away from their disposal sites. For example, the treated liquid wastes released into Mortandad Canyon at the Los Alamos National Laboratory were predicted to travel less than a few meters; however, plutonium and americium have been detected 3.4 km away from the waste outfall. A colloid-facilitated mechanism has been suggested to account for this unexpected transport of these radioactive wastes. Clays, oxides, organic matters, and actinide hydroxides have all been proposed as the possible mobile phase. Pu ions associated with natural colloids are often referred to as pseudo-Pu colloids, in contrast with the intrinsic Pu colloids that consist of Pu oxides. Significant efforts have been made to investigate the role of pseudo-Pu colloids, while few studies have evaluated the environmental behavior of the intrinsic Pu colloids. Given the fact that Pu (IV) has extremely low solubility product constant, it can be inferred that the transport of Pu in the intrinsic form is highly likely at suitable environmental conditions. This study investigates the transport of intrinsic Pu colloids in a saturated alluvium material packed in a cylindrical column (2.5-cm Dia. x 30-cm high) and compares the results to previous data on the transport of pseudo Pu colloids in the same material. A procedure to prepare a stable intrinsic Pu colloid suspension that produced consistent and reproducible electrokinetic and stability data was developed. Electrokinetic properties and aggregation stability were characterized. The Pu colloids, together with trillium as a conservative tracer, were injected into the

  1. Viscous dark fluid universe

    SciTech Connect

    Hipolito-Ricaldi, W. S.; Velten, H. E. S.; Zimdahl, W.

    2010-09-15

    We investigate the cosmological perturbation dynamics for a universe consisting of pressureless baryonic matter and a viscous fluid, the latter representing a unified model of the dark sector. In the homogeneous and isotropic background the total energy density of this mixture behaves as a generalized Chaplygin gas. The perturbations of this energy density are intrinsically nonadiabatic and source relative entropy perturbations. The resulting baryonic matter power spectrum is shown to be compatible with the 2dFGRS and SDSS (DR7) data. A joint statistical analysis, using also Hubble-function and supernovae Ia data, shows that, different from other studies, there exists a maximum in the probability distribution for a negative present value q{sub 0{approx_equal}}-0.53 of the deceleration parameter. Moreover, while previous descriptions on the basis of generalized Chaplygin-gas models were incompatible with the matter power-spectrum data since they required a much too large amount of pressureless matter, the unified model presented here favors a matter content that is of the order of the baryonic matter abundance suggested by big-bang nucleosynthesis.

  2. A Custom Made Intrinsic Silicone Shade Guide for Indian Population

    PubMed Central

    Behanam, Mohammed; Ahila, S.C.; Jei, J. Brintha

    2016-01-01

    Introduction Replication of natural skin colour in maxillofacial prosthesis has been traditionally done using trial and error method, as concrete shade guides are unavailable till date. Hence a novel custom made intrinsic silicone shade guide has been attempted for Indian population. Aim Reconstruction of maxillofacial defects is challenging, as achieving an aesthetic result is not always easy. A concoction of a novel intrinsic silicone shade guide was contemplated for the study and its reproducibility in clinical practice was analysed. Materials and Methods Medical grade room temperature vulcanising silicone was used for the fabrication of shade tabs. The shade guide consisted of three main groups I, II and III which were divided based upon the hues yellow, red and blue respectively. Five distinct intrinsic pigments were added in definite proportions to subdivide each group of different values from lighter to darker shades. A total number of 15 circular shade tabs comprised the guide. To validate the usage of the guide, visual assessment of colour matching was done by four investigators to investigate the consent of perfect colour correspondence. Data was statistically analysed using kappa coefficients. Results The kappa values were found to be 0.47 to 0.78 for yellow based group I, 0.13 to 0.65 for red based group II, and 0.07 to 0.36 for blue based group III. This revealed that the shade tabs of yellow and red based hues matched well and showed a statistically good colour matching. Conclusion This intrinsic silicone shade guide can be effectively utilised for fabrication of maxillofacial prosthesis with silicone in Indian population. A transparent colour formula with definite proportioning of intrinsic pigments is provided for obtaining an aesthetic match to skin tone. PMID:27190946

  3. Cell Intrinsic Role of Cox-2 in Pancreatic Cancer Development

    PubMed Central

    Hill, Reginald; Li, Yunfeng; Tran, Linh M.; Dry, Sarah; Calvopina, Joseph Hargan; Garcia, Alejandro; Kim, Christine; Wang, Ying; Donahue, Timothy R.; Herschman, Harvey R.; Wu, Hong

    2012-01-01

    Cyclooxygenase-2 (COX-2) is upregulated in pancreatic ductal adenocarcinomas (PDAC). However, how COX-2 promotes PDAC development is unclear. While previous studies have evaluated the efficacy of COX-2 inhibition via the use of non steroidal anti-inflammatory drugs (NSAIDs) or the COX-2 inhibitor celecoxib in PDAC models, none have addressed the cell intrinsic vs. microenvironment roles of COX-2 in modulating PDAC initiation and progression. We tested the cell intrinsic role of COX-2 in PDAC progression, using both loss-of-function and gain-of-function approaches. Cox-2 deletion in Pdx1+ pancreatic progenitor cells significantly delays the development of PDAC in mice with K-ras activation and Pten haploinsufficiency. Conversely, COX-2 over-expression promotes early onset and progression of PDAC in the K-ras mouse model. Loss of PTEN function is a critical factor in determining lethal PDAC onset and overall survival. Mechanistically, COX-2 over-expression increases P-AKT levels in the precursor lesions of Pdx1+;K-rasG12D/+;Ptenlox/+ mice in the absence of Pten LOH. In contrast, Cox-2 deletion in the same setting diminishes P-AKT levels and delays cancer progression. These data suggest an important cell intrinsic role for COX-2 in tumor initiation and progression through activation of the PI3K/AKT pathway. PDAC that is independent of intrinsic COX-2 expression eventually develops with decreased FKBP5 and increased GRP78 expression, two alternate pathways leading to AKT activation. Together, these results support a cell intrinsic role for COX-2 in PDAC development and suggest that, while anti-COX-2 therapy may delay the development and progression of PDAC, mechanisms known to increase chemoresistance through AKT activation must also be overcome. PMID:22784710

  4. Intrinsic motivation and learning in a schizophrenia spectrum sample.

    PubMed

    Choi, Jimmy; Medalia, Alice

    2010-05-01

    A motivation is a telling hallmark of negative symptomatology in schizophrenia, and it impacts nearly every facet of behavior, including inclination to attempt the difficult cognitive tasks involved in cognitive remediation therapy. Experiences of external reward, reinforcement, and hedonic anticipatory enjoyment are diminished in psychosis, so therapeutics which instead target intrinsic motivation for cognitive tasks may enhance task engagement, and subsequently, remediation outcome. We examined whether outpatients could attain benefits from an intrinsically motivating instructional approach which (a) presents learning materials in a meaningful game-like context, (b) personalizes elements of the learning materials into themes of high interest value, and (c) offers choices so patients can increase their control over the learning process. We directly compared one learning method that incorporated the motivational paradigm into an arithmetic learning program against another method that carefully manipulated out the motivational variables in the same learning program. Fifty-seven subjects with schizophrenia or schizoaffective disorder were randomly assigned to one of the two learning programs for 10 thirty-minute sessions while an intent-to-treat convenience subsample (n=15) was used to account for practice effect. Outcome measures were arithmetic learning, attention, motivation, self competency, and symptom severity. Results showed the motivational group (a) acquired more arithmetic skill, (b) possessed greater intrinsic motivation for the task, (c) reported greater feelings of self competency post-treatment, and (d) demonstrated better post-test attention. Interestingly, baseline perception of self competency was a significant predictor of post-test arithmetic scores. Results demonstrated that incorporating intrinsically motivating instructional techniques into a difficult cognitive task promoted greater learning of the material, higher levels of intrinsic

  5. University lobbying

    NASA Astrophysics Data System (ADS)

    Richman, Barbara T.

    In the past year, an increasing number of individual academic institutions have lobbied in Congress for new science facilities funds thus circumventing the traditional peer review process of evaluating the merits of such facilities. As an attempt to stem this rising tide, the National Academy of Sciences (NAS) governing council and the Association of American Universities (AAU) recently and independently issued strong statements condemning lobbying by individual universities and enthusiastically supporting the peer review system.“Informed peer judgments on the scientific merits of specific proposals, in open competition, should be a central element in the awarding of all federal funds for science,” the NAS resolution stated. AAU, meanwhile, implored “scientists, leaders of America's universities, and members of Congress” to “refrain from actions that would make scientific decisions a test of political influence rather than a judgment on the quality of the work to be done.” Roughly 50 research institutions constitute AAU; the two AAU Canadian members did not vote on the consortium's statement.

  6. Intrinsic Advance Primers: An Investigation of the Effects of Personalized Extraneous Multimedia upon Intrinsic Interest and Student Achievement

    ERIC Educational Resources Information Center

    Williams, Matthew Anthony

    2012-01-01

    The purpose of this study was to investigate if the delivery of personalized extraneous multimedia (PEM) messages prior to the delivery of the primary instructional materials could prime intrinsic interest and have a positive impact upon achievement in comparison to the use of non-personalized extraneous multimedia (NPEM). Extraneous materials are…

  7. Recapturing the Universal in the University

    ERIC Educational Resources Information Center

    Barnett, Ronald

    2005-01-01

    The idea of "the university" has stood for universal themes--of knowing, of truthfulness, of learning, of human development, and of critical reason. Through its affirming and sustaining of such themes, the university came itself to stand for universality in at least two senses: the university was neither partial (in its truth criteria) nor local…

  8. Ian's Universe

    NASA Astrophysics Data System (ADS)

    Kogan, Bella

    Everyone has their own private universe. Ian's was immense and diverse. But there are two main parts that determined his world. One was of course PHYSICS. He was one of the rare breed for whom there was only one possible way of life. 10 years ago when his job prospects were bleak he was thinking of quitting physics and becoming a "taxi driver" which meant a financial analyst, a programmer, anything. For him all professions divided into two categories — physics and non-physics, a "taxi driver"…

  9. Open University

    ScienceCinema

    None

    2016-07-12

    Michel Pentz est née en Afrique du Sud et venu au Cern en 1957 comme physicien et président de l'associaion du personnel. Il est également fondateur du mouvement Antiapartheid de Genève et a participé à la fondation de l'Open University en Grande-Bretagne. Il nous parle des contextes pédagogiques, culturels et nationaux dans lesquels la méthode peut s'appliquer.

  10. Magnetic alignment of block copolymer microdomains by intrinsic chain anisotropy

    DOE PAGES

    Rokhlenko, Yekaterina; Yager, Kevin G.; Gopinadhan, Manesh; ...

    2015-12-18

    We examine the role of intrinsic chain susceptibility anisotropy in magnetic field directed self-assembly of a block copolymer using in situ x-ray scattering. Alignment of a lamellar mesophase is observed on cooling across the disorder-order transition with the resulting orientational order inversely proportional to the cooling rate. We discuss the origin of the susceptibility anisotropy, Δχ, that drives alignment and calculate its magnitude using coarse-grained molecular dynamics to sample conformations of surface-tethered chains, finding Δχ ≈ 2×10–8. From field-dependent scattering data, we estimate that grains of ≈ 1.2 μm are present during alignment. Furthermore, these results demonstrate that intrinsic anisotropymore » is sufficient to support strong field-induced mesophase alignment and suggest a versatile strategy for field control of orientational order in block copolymers.« less

  11. Folding propensity of intrinsically disordered proteins by osmotic stress

    SciTech Connect

    Mansouri, Amanda L.; Grese, Laura N.; Rowe, Erica L.; Pino, James C.; Chennubhotla, S. Chakra; Ramanathan, Arvind; O'Neill, Hugh Michael; Berthelier, Valerie; Stanley, Christopher B.

    2016-10-11

    Proteins imparted with intrinsic disorder conduct a range of essential cellular functions. To better understand the folding and hydration properties of intrinsically disordered proteins (IDPs), we used osmotic stress to induce conformational changes in nuclear co-activator binding domain (NCBD) and activator for thyroid hormone and retinoid receptor (ACTR). Osmotic stress was applied by the addition of small and polymeric osmolytes, where we discovered that water contributions to NCBD folding always exceeded those for ACTR. Both NCBD and ACTR were found to gain a-helical structure with increasing osmotic stress, consistent with their folding upon NCBD/ACTR complex formation. Using small-angle neutron scattering (SANS), we further characterized NCBD structural changes with the osmolyte ethylene glycol. Here a large reduction in overall size initially occurred before substantial secondary structural change. In conclusion, by focusing on folding propensity, and linked hydration changes, we uncover new insights that may be important for how IDP folding contributes to binding.

  12. Senescence-associated intrinsic mechanisms of osteoblast dysfunctions.

    PubMed

    Kassem, Moustapha; Marie, Pierre J

    2011-04-01

    Human aging is associated with bone loss leading to bone fragility and increased risk of fractures. The cellular and molecular causes of age-related bone loss are current intensive topic of investigation with the aim of identifying new approaches to abolish its negative effects on the skeleton. Age-related osteoblast dysfunction is the main cause of age-related bone loss in both men and women beyond the fifth decade and results from two groups of pathogenic mechanisms: extrinsic mechanisms that are mediated by age-related changes in bone microenvironment including changes in levels of hormones and growth factors, and intrinsic mechanisms caused by the osteoblast cellular senescence. The aim of this review is to provide a summary of the intrinsic senescence mechanisms affecting osteoblastic functions and how they can be targeted to abolish age-related osteoblastic dysfunction and bone loss associated with aging.

  13. Magnetic alignment of block copolymer microdomains by intrinsic chain anisotropy

    SciTech Connect

    Rokhlenko, Yekaterina; Yager, Kevin G.; Gopinadhan, Manesh; Osuji, Chinedum O.; Zhang, Kai; O'Hern, Corey S.; Larson, Steven R.; Gopalan, Padma; Majewski, Pawel W.

    2015-12-18

    We examine the role of intrinsic chain susceptibility anisotropy in magnetic field directed self-assembly of a block copolymer using in situ x-ray scattering. Alignment of a lamellar mesophase is observed on cooling across the disorder-order transition with the resulting orientational order inversely proportional to the cooling rate. We discuss the origin of the susceptibility anisotropy, Δχ, that drives alignment and calculate its magnitude using coarse-grained molecular dynamics to sample conformations of surface-tethered chains, finding Δχ ≈ 2×10–8. From field-dependent scattering data, we estimate that grains of ≈ 1.2 μm are present during alignment. Furthermore, these results demonstrate that intrinsic anisotropy is sufficient to support strong field-induced mesophase alignment and suggest a versatile strategy for field control of orientational order in block copolymers.

  14. Intrinsic periodicity: the forgotten lesson of quantum mechanics

    NASA Astrophysics Data System (ADS)

    Dolce, Donatello

    2013-06-01

    Wave-particle duality, together with the concept of elementary particles, was introduced by de Broglie in terms of intrinsically periodic phenomena. However, after nearly 90 years, the physical origin of such undulatory mechanics remains unrevealed. We propose a natural realization of the de Broglie periodic phenomenon in terms of harmonic vibrational modes associated to space-time periodicities. In this way we find that, similarly to a vibrating string or a particle in a box, the intrinsic recurrence imposed as a constraint to elementary particles represents a fully consistent quantization condition. The resulting cyclic dynamics formally match ordinary relativistic Quantum Mechanics in both the canonical and Feynman formulations. Interactions are introduced in a geometrodynamical way, similarly to general relativity, by simply considering that variations of kinematical state can be equivalently described in terms of modulations of space-time recurrences, as known from undulatory mechanics. We present this novel quantization prescription from an historical prospective.

  15. Resonant wave-particle interactions modified by intrinsic Alfvenic turbulence

    SciTech Connect

    Wu, C. S.; Lee, K. H.; Wang, C. B.; Wu, D. J.

    2012-08-15

    The concept of wave-particle interactions via resonance is well discussed in plasma physics. This paper shows that intrinsic Alfven waves can qualitatively modify the physics discussed in conventional linear plasma kinetic theories. It turns out that preexisting Alfven waves can affect particle motion along the ambient magnetic field and, moreover, the ensuing force field is periodic in time. As a result, the meaning of the usual Landau and cyclotron resonance conditions becomes questionable. It turns out that this effect leads us to find a new electromagnetic instability. In such a process intrinsic Alfven waves not only modify the unperturbed distribution function but also result in a different type of cyclotron resonance which is affected by the level of turbulence. This instability might enable us to better our understanding of the observed radio emission processes in the solar atmosphere.

  16. Intrinsic parallel rotation drive by electromagnetic ion temperature gradient turbulence

    NASA Astrophysics Data System (ADS)

    Peng, Shuitao; Wang, Lu; Pan, Yuan

    2017-03-01

    The quasilinear intrinsic parallel flow drive including parallel residual stress, kinetic stress, cross Maxwell stress and parallel turbulent acceleration by electromagnetic ion temperature gradient (ITG) turbulence is calculated analytically using electromagnetic gyrokinetic theory. Both the kinetic stress and cross Maxwell stress also enter the mean parallel flow velocity equation via their divergence, as for the usual residual stress. The turbulent acceleration driven by ion pressure gradient along the total magnetic field (including equilibrium magnetic field and fluctuating radial magnetic field) cannot be written as a divergence of stress, and so should be treated as a local source/sink. All these terms can provide intrinsic parallel rotation drive. Electromagnetic effects reduce the non-resonant electrostatic stress force and even reverse it, but enhance the resonant stress force. Both the non-resonant and resonant turbulent acceleration terms are also enhanced by electromagnetic effects. The possible implications of our results for experimental observations are discussed.

  17. Protein amyloids develop an intrinsic fluorescence signature during aggregation†

    PubMed Central

    Chan, Fiona T. S.; Kaminski Schierle, Gabriele S.; Kumita, Janet R.; Bertoncini, Carlos W.; Dobson, Christopher M.; Kaminski, Clemens F.

    2017-01-01

    We report observations of an intrinsic fluorescence in the visible range, which develops during the aggregation of a range of polypeptides, including the disease-related human peptides amyloid-β(1–40) and (1–42), lysozyme and tau. Characteristic fluorescence properties such as the emission lifetime and spectra were determined experimentally. This intrinsic fluorescence is independent of the presence of aromatic side-chain residues within the polypeptide structure. Rather, it appears to result from electronic levels that become available when the polypeptide chain folds into a cross-β sheet scaffold similar to what has been reported to take place in crystals. We use these findings to quantify protein aggregation in vitro by fluorescence imaging in a label-free manner. PMID:23420088

  18. A Modified Theoretical Model of Intrinsic Hardness of Crystalline Solids.

    PubMed

    Dai, Fu-Zhi; Zhou, Yanchun

    2016-09-08

    Super-hard materials have been extensively investigated due to their practical importance in numerous industrial applications. To stimulate the design and exploration of new super-hard materials, microscopic models that elucidate the fundamental factors controlling hardness are desirable. The present work modified the theoretical model of intrinsic hardness proposed by Gao. In the modification, we emphasize the critical role of appropriately decomposing a crystal to pseudo-binary crystals, which should be carried out based on the valence electron population of each bond. After modification, the model becomes self-consistent and predicts well the hardness values of many crystals, including crystals composed of complex chemical bonds. The modified model provides fundamental insights into the nature of hardness, which can facilitate the quest for intrinsic super-hard materials.

  19. Intrinsic Spin Hall Effect in the Two Dimensional Hole Gas

    SciTech Connect

    Bernevig, B.Andrei; Zhang, Shou-Cheng; /Stanford U., Phys. Dept.

    2010-01-15

    We show that two types of spin-orbit coupling in the 2 dimensional hole gas (2DHG), with and without inversion symmetry breaking, contribute to the intrinsic spin Hall effect. Furthermore, the vertex correction due to impurity scattering vanishes in both cases, in sharp contrast to the case of usual Rashba coupling in the electron band. Recently, the spin Hall effect in a hole doped GaAs semiconductor has been observed experimentally by Wunderlich et al. From the fact that the life time broadening is smaller than the spin splitting, and the fact impurity vertex corrections vanish in this system, we argue that the observed spin Hall effect should be in the intrinsic regime.

  20. A Modified Theoretical Model of Intrinsic Hardness of Crystalline Solids

    PubMed Central

    Dai, Fu-Zhi; Zhou, Yanchun

    2016-01-01

    Super-hard materials have been extensively investigated due to their practical importance in numerous industrial applications. To stimulate the design and exploration of new super-hard materials, microscopic models that elucidate the fundamental factors controlling hardness are desirable. The present work modified the theoretical model of intrinsic hardness proposed by Gao. In the modification, we emphasize the critical role of appropriately decomposing a crystal to pseudo-binary crystals, which should be carried out based on the valence electron population of each bond. After modification, the model becomes self-consistent and predicts well the hardness values of many crystals, including crystals composed of complex chemical bonds. The modified model provides fundamental insights into the nature of hardness, which can facilitate the quest for intrinsic super-hard materials. PMID:27604165

  1. Can proteins be intrinsically disordered inside a membrane?

    PubMed Central

    Kjaergaard, Magnus

    2015-01-01

    Intrinsically disorder has evolved in many soluble proteins because it confers a unique set of functional advantages. In contrast, the functions of membrane proteins are largely understood in terms of well-defined structures. This raises the question: Why would the evolutionary pressures that select for disorder leave membrane proteins untouched. In this hypothesis piece, I argue that intrinsic disorder may exist in membrane embedded proteins, but that it will take a different form due to the different environment. Disordered membrane proteins are thus likely to have fully formed secondary structure, but little tertiary structure. Furthermore, the sequence signature for disorder in membrane proteins is likely to be reversed; so disordered proteins are more hydrophobic than their folded counterparts. At present it is impossible to tell how common this type of disordered membrane protein is.

  2. Intrinsic and extrinsic mechanisms regulating satellite cell function.

    PubMed

    Dumont, Nicolas A; Wang, Yu Xin; Rudnicki, Michael A

    2015-05-01

    Muscle stem cells, termed satellite cells, are crucial for skeletal muscle growth and regeneration. In healthy adult muscle, satellite cells are quiescent but poised for activation. During muscle regeneration, activated satellite cells transiently re-enter the cell cycle to proliferate and subsequently exit the cell cycle to differentiate or self-renew. Recent studies have demonstrated that satellite cells are heterogeneous and that subpopulations of satellite stem cells are able to perform asymmetric divisions to generate myogenic progenitors or symmetric divisions to expand the satellite cell pool. Thus, a complex balance between extrinsic cues and intrinsic regulatory mechanisms is needed to tightly control satellite cell cycle progression and cell fate determination. Defects in satellite cell regulation or in their niche, as observed in degenerative conditions such as aging, can impair muscle regeneration. Here, we review recent discoveries of the intrinsic and extrinsic factors that regulate satellite cell behaviour in regenerating and degenerating muscles.

  3. Intrinsic Negative Poisson's Ratio for Single-Layer Graphene.

    PubMed

    Jiang, Jin-Wu; Chang, Tienchong; Guo, Xingming; Park, Harold S

    2016-08-10

    Negative Poisson's ratio (NPR) materials have drawn significant interest because the enhanced toughness, shear resistance, and vibration absorption that typically are seen in auxetic materials may enable a range of novel applications. In this work, we report that single-layer graphene exhibits an intrinsic NPR, which is robust and independent of its size and temperature. The NPR arises due to the interplay between two intrinsic deformation pathways (one with positive Poisson's ratio, the other with NPR), which correspond to the bond stretching and angle bending interactions in graphene. We propose an energy-based deformation pathway criteria, which predicts that the pathway with NPR has lower energy and thus becomes the dominant deformation mode when graphene is stretched by a strain above 6%, resulting in the NPR phenomenon.

  4. Quarterly intrinsic disorder digest (January-February-March, 2014)

    PubMed Central

    DeForte, Shelly; Reddy, Krishna D.; Uversky, Vladimir N.

    2016-01-01

    ABSTRACT This is the 5th issue of the Digested Disorder series that represents a reader's digest of the scientific literature on intrinsically disordered proteins. We continue to use only 2 criteria for inclusion of a paper to this digest: The publication date (a paper should be published within the covered time frame) and the topic (a paper should be dedicated to any aspect of protein intrinsic disorder). The current digest issue covers papers published during the first quarter of 2014; i.e., during the period of January, February, and March of 2014. Similar to previous issues, the papers are grouped hierarchically by topics they cover, and for each of the included papers a short description is given on its major findings. PMID:28232896

  5. Intrinsic borohydride fuel cell/battery hybrid power sources

    NASA Astrophysics Data System (ADS)

    Hong, Jian; Fang, Bin; Wang, Chunsheng; Currie, Kenneth

    The electrochemical oxidation behaviors of NaBH 4 on Zn, Zn-MH, and MH (metal-hydride) electrodes were investigated, and an intrinsic direct borohydride fuel cell (DBFC)/battery hybrid power source using MH (or Zn-MH) as the anode and MnO 2 as the cathode was tested. Borohydride cannot be effectively oxidized on Zn electrodes at the Zn oxidation potential because of the poor electrocatalytic ability of Zn for borohydride oxidation and the high overpotential, even though borohydride has the same oxidation potential of Zn in an alkaline solution. The borohydride can be electrochemically oxidized on Ni and MH electrodes through a 4e reaction at a high overpotential. Simply adding borohydride into an alkaline electrolyte of a Zn/air or MH/air battery can greatly increase the capacity, while an intrinsic DBFC/MH(or Zn)-MnO 2 battery can deliver a higher peak power than regular DBFCs.

  6. Magnetic Alignment of Block Copolymer Microdomains by Intrinsic Chain Anisotropy

    NASA Astrophysics Data System (ADS)

    Rokhlenko, Yekaterina; Gopinadhan, Manesh; Osuji, Chinedum O.; Zhang, Kai; O'Hern, Corey S.; Larson, Steven R.; Gopalan, Padma; Majewski, Paweł W.; Yager, Kevin G.

    2015-12-01

    We examine the role of intrinsic chain susceptibility anisotropy in magnetic field directed self-assembly of a block copolymer using in situ x-ray scattering. Alignment of a lamellar mesophase is observed on cooling across the disorder-order transition with the resulting orientational order inversely proportional to the cooling rate. We discuss the origin of the susceptibility anisotropy, Δ χ , that drives alignment and calculate its magnitude using coarse-grained molecular dynamics to sample conformations of surface-tethered chains, finding Δ χ ≈2 ×1 0-8. From field-dependent scattering data, we estimate that grains of ≈1.2 μ m are present during alignment. These results demonstrate that intrinsic anisotropy is sufficient to support strong field-induced mesophase alignment and suggest a versatile strategy for field control of orientational order in block copolymers.

  7. Intrinsic Oscillations of Neocortex Generated by Layer 5 Pyramidal Neurons

    NASA Astrophysics Data System (ADS)

    Silva, Laurie R.; Amitai, Yael; Connors, Barry W.

    1991-01-01

    Rhythmic activity in the neocortex varies with different behavioral and pathological states and in some cases may encode sensory information. However, the neural mechanisms of these oscillations are largely unknown. Many pyramidal neurons in layer 5 of the neocortex showed prolonged, 5- to 12-hertz rhythmic firing patterns at threshold. Rhythmic firing was due to intrinsic membrane properties, sodium conductances were essential for rhythmicity, and calcium-dependent conductances strongly modified rhythmicity. Isolated slices of neocortex generated epochs of 4- to 10-hertz synchronized activity when N-methyl-D-aspartate receptor-mediated channels were facilitated. Layer 5 was both necessary and sufficient to produce these synchronized oscillations. Thus, synaptic networks of intrinsically rhythmic neurons in layer 5 may generate or promote certain synchronized oscillations of the neocortex.

  8. Intrinsically Disordered Proteins Drive Emergence and Inheritance of Biological Traits.

    PubMed

    Chakrabortee, Sohini; Byers, James S; Jones, Sandra; Garcia, David M; Bhullar, Bhupinder; Chang, Amelia; She, Richard; Lee, Laura; Fremin, Brayon; Lindquist, Susan; Jarosz, Daniel F

    2016-10-06

    Prions are a paradigm-shifting mechanism of inheritance in which phenotypes are encoded by self-templating protein conformations rather than nucleic acids. Here, we examine the breadth of protein-based inheritance across the yeast proteome by assessing the ability of nearly every open reading frame (ORF; ∼5,300 ORFs) to induce heritable traits. Transient overexpression of nearly 50 proteins created traits that remained heritable long after their expression returned to normal. These traits were beneficial, had prion-like patterns of inheritance, were common in wild yeasts, and could be transmitted to naive cells with protein alone. Most inducing proteins were not known prions and did not form amyloid. Instead, they are highly enriched in nucleic acid binding proteins with large intrinsically disordered domains that have been widely conserved across evolution. Thus, our data establish a common type of protein-based inheritance through which intrinsically disordered proteins can drive the emergence of new traits and adaptive opportunities.

  9. Intrinsic randomness as a measure of quantum coherence

    NASA Astrophysics Data System (ADS)

    Yuan, Xiao; Zhou, Hongyi; Cao, Zhu; Ma, Xiongfeng

    2015-08-01

    Based on the theory of quantum mechanics, intrinsic randomness in measurement distinguishes quantum effects from classical ones. From the perspective of states, this quantum feature can be summarized as coherence or superposition in a specific (classical) computational basis. Recently, by regarding coherence as a physical resource, Baumgratz et al. [Phys. Rev. Lett. 113, 140401 (2014), 10.1103/PhysRevLett.113.140401] presented a comprehensive framework for coherence measures. Here, we propose a quantum coherence measure essentially using the intrinsic randomness of measurement. The proposed coherence measure provides an answer to the open question in completing the resource theory of coherence. Meanwhile, we show that the coherence distillation process can be treated as quantum extraction, which can be regarded as an equivalent process of classical random number extraction. From this viewpoint, the proposed coherence measure also clarifies the operational aspect of quantum coherence. Finally, our results indicate a strong similarity between two types of quantumness—coherence and entanglement.

  10. Neuronal intrinsic barriers for axon regeneration in the adult CNS

    PubMed Central

    Sun, Fang; He, Zhigang

    2010-01-01

    A major reason for the devastating and permanent disabilities after spinal cord and other types of CNS injury is the failure of injured axons to regenerate and to re-build the functional circuits. Thus, a long-standing goal has been to develop strategies that could promote axon regeneration and restore functions. Recent studies revealed that simply removing extracellular inhibitory activities is insufficient for successful axon regeneration in the adult CNS. On the other side, evidence from different species and different models is accumulating to support the notion that diminished intrinsic regenerative ability of mature neurons is a major contributor to regeneration failure. This review will summarize the molecular mechanisms regulating intrinsic axon growth capacity in the adult CNS and discuss potential implications for therapeutic strategies. PMID:20418094

  11. On The intrinsic equation behind the Delaunay surfaces

    SciTech Connect

    Mladenov, Ivaielo M.; Hadzhilazova, Mariana Ts.; Djondjorov, Peter A.; Vassilev, Vassil M.

    2008-11-18

    By balancing the internal and external forces acting on axially symmetric membranes one arrives at a system of two equations describing the equilibrium states. This system allows at least two sets of analytical solutions. One of them presents the Euler's elasticas and the other one can be recognized as the class of Delaunay surfaces. The intrinsic equation describing the profile curves of the later is found and solved and this leads to new analytical formulas for these surfaces.

  12. Plastic Deformation Influence on Intrinsic Magnetic Field of Austenitic Biomaterials

    NASA Astrophysics Data System (ADS)

    Smetana, Milan; Čápová, Klára; Chudáčik, Vladimír; Palček, Peter; Oravcová, Monika

    2016-12-01

    This article deals with non-destructive evaluation of austenitic stainless steels, which are used as the biomaterials in medical practice. Intrinsic magnetic field is investigated using the fluxgate sensor, after the applied plastic deformation. The three austenitic steel types are studied under the same conditions, while several values of the deformation are applied, respectively. The obtained results are presented and discussed in the paper.

  13. Are There Intrinsically X-Ray Quiet Quasars

    NASA Technical Reports Server (NTRS)

    Gallagher, S. C.; Brandt, W. N.; Laor, A.; Elvis, Martin; Mathur, S.; Wills, Beverly J.; Iyomoto, N.; White, Nicholas (Technical Monitor)

    2000-01-01

    Recent ROSAT studies have identified a significant population of Active Galactic Nuclei (AGN) that are notably faint in soft X-rays relative to their optical fluxes. Are these AGN intrinsically X-ray weak or are they just highly absorbed? Brandt, Laor & Wills have systematically examined the optical and UV spectral properties of a well-defined sample of these soft X-ray weak (SXW) AGN drawn from the Boroson & Green sample of all the Palomar Green AGN 00 with z < 0.5. We present ASCA observations of three of these SXW AGN: PG 1011-040, PG 1535+547 (Mrk 486), and PG 2112+059. In general, our ASCA observations support the intrinsic absorption scenario for explaining soft X-ray weakness; both PG 1535+547 and PG 2112+059 show significant column densities (NH is approximately 10(exp 22) - 10(exp 23)/sq cm) of absorbing gas. Interestingly, PG 1011-040 shows no spectral evidence for X-ray absorption. The weak X-ray emission may result from very strong absorption of a partially covered source, or this AGN may be intrinsically X-ray weak. PG 2112+059 is a Broad Absorption Line (BAL) QSO, and we find it to have the highest X-ray flux known of this class. It shows a typical power-law X-ray continuum above 3 keV; this is the first direct evidence that BAL QSOs indeed have normal X-ray continua underlying their intrinsic absorption. Finally, marked variability between the ROSAT and ASCA observations of PG 1535+547 and PG 2112+059 suggests that the soft X-ray weak designation may be transient, and multi-epoch 0.1-10.0 KeV X-ray observations are required to constrain variability of the absorber and continuum.

  14. The Development of Intrinsic Motivation for Physical Activity

    DTIC Science & Technology

    2005-07-01

    individuals to become more intrinsically motivated to engage in regular exercise and/or physical activity . This paper will present theories...an exercise or physical activity program. DiClemente and Velasquez (2002) make the 29 argument that people in the preparation stage may have...they are making are worthy of 30 Do you currently do any physical exercise ? Do you intend to do some vigorous physical activity in the next six

  15. Large-scale structure and the intrinsic alignment of galaxies

    NASA Astrophysics Data System (ADS)

    Blazek, Jonathan; Seljak, Uroš; Mandelbaum, Rachel

    2016-10-01

    Coherent alignments of galaxy shapes, often called``intrinsic alignments'' (IA), are the most significant source of astrophysical uncertainty in weak lensing measurements. We develop the tidal alignment model of IA and demonstrate its success in describing observational data. We also describe a technique to separate IA from galaxy-galaxy lensing measurements. Applying this technique to luminous red galaxy lenses in the Sloan Digital Sky Survey, we constrain potential IA contamination from associated sources to be below a few percent.

  16. Clinical implications of the intrinsic molecular subtypes of breast cancer.

    PubMed

    Prat, Aleix; Pineda, Estela; Adamo, Barbara; Galván, Patricia; Fernández, Aranzazu; Gaba, Lydia; Díez, Marc; Viladot, Margarita; Arance, Ana; Muñoz, Montserrat

    2015-11-01

    Gene-expression profiling has had a considerable impact on our understanding of breast cancer biology. During the last 15 years, 5 intrinsic molecular subtypes of breast cancer (Luminal A, Luminal B, HER2-enriched, Basal-like and Claudin-low) have been identified and intensively studied. In this review, we will focus on the current and future clinical implications of the intrinsic molecular subtypes beyond the current pathological-based classification endorsed by the 2013 St. Gallen Consensus Recommendations. Within hormone receptor-positive and HER2-negative early breast cancer, the Luminal A and B subtypes predict 10-year outcome regardless of systemic treatment administered as well as residual risk of distant recurrence after 5 years of endocrine therapy. Within clinically HER2-positive disease, the 4 main intrinsic subtypes can be identified and dominate the biological and clinical phenotype. From a clinical perspective, patients with HER2+/HER2-enriched disease seem to benefit the most from neoadjuvant trastuzumab, or dual HER2 blockade with trastuzumab/lapatinib, in combination with chemotherapy, and patients with HER2+/Luminal A disease seem to have a relative better outcome compared to the other subtypes. Finally, within triple-negative breast cancer (TNBC), the Basal-like disease predominates (70-80%) and, from a biological perspective, should be considered a cancer-type by itself. Importantly, the distinction between Basal-like versus non-Basal-like within TNBC might predict survival following (neo)adjvuvant multi-agent chemotherapy, bevacizumab benefit in the neoadjuvant setting (CALGB40603), and docetaxel vs. carboplatin benefit in first-line metastatic disease (TNT study). Overall, this data suggests that intrinsic molecular profiling provides clinically relevant information beyond current pathology-based classifications.

  17. Disorder in milk proteins: caseins, intrinsically disordered colloids.

    PubMed

    Redwan, Elrashdy M; Xue, Bin; Almehdar, Hussein A; Uversky, Vladimir N

    2015-01-01

    This article opens a series of reviews on the abundance and roles of intrinsic disorder in milk proteins. The focus of this introductory article on caseins is symbolic, since caseins were among the first recognized functional unfolded proteins and since they are definitely the most disordered, the most abundant, and the most studied of all milk proteins. In eutherian milks, the casein family includes at least three and usually four major members (αs1-, αs2-, β-, and κ-caseins) that are unrelated in sequence. However, in some species, two different αS2-casein genes are active, and therefore the total number of caseins can be as high as five. These proteins have found a number of uses in food industry. The functional repertoire of caseins ranges from nutritional function to involvement in the improving and/or maintaining cardiovascular health, to crucial contribution to the milk capacity to transport calcium phosphate, to serve as molecular chaperones, and to protect the mother's mammary gland against amyloidoses and ectopic calcification. An intricate feature of caseins is their ability to assemble to colloidal protein particles, casein micelles, serving to sequester and transport amorphous calcium phosphate. These and many other functions of caseins are obviously dependent on their intrinsically disordered nature and are controlled by various posttranslational modifications. Since various aspects of casein structure and function are rather well studied and since several recent reviews emphasized the functional roles of caseins' intrinsic disorder, the major goal of this article is to show how intrinsic disorder is encoded in the amino acid sequences of these proteins.

  18. Intrinsic spin Seebeck effect in Au/YIG.

    PubMed

    Qu, D; Huang, S Y; Hu, Jun; Wu, Ruqian; Chien, C L

    2013-02-08

    The acute magnetic proximity effects in Pt/YIG compromise the suitability of Pt as a spin current detector. We show that Au/YIG, with no anomalous Hall effect and a negligible magnetoresistance, allows the measurements of the intrinsic spin Seebeck effect with a magnitude much smaller than that in Pt/YIG. The experiment results are consistent with the spin polarized density functional calculations for Pt with a sizable and Au with a negligible magnetic moment near the interface with YIG.

  19. Electronegativity and intrinsic disorder of preeclampsia-related proteins.

    PubMed

    Polanco, Carlos; Castañón-González, Jorge Alberto; Uversky, Vladimir N; Buhse, Thomas; Samaniego Mendoza, José Lino; Calva, Juan J

    2017-01-01

    Preeclampsia, hemorrhage, and infection are the leading causes of maternal death in underdeveloped countries. Since several proteins associated with preeclampsia are known, we conducted a computational study which evaluated the commonness and potential functionality of intrinsic disorder of these proteins and also made an attempt to characterize their origin. The origin of the preeclampsia-related proteins was assessed with a supervised technique, a Polarity Index Method (PIM), which evaluates the electronegativity of proteins based solely on their sequence. The commonness of intrinsic disorder was evaluated using several disorder predictors from the PONDR family, the charge-hydropathy plot (CH-plot) and cumulative distribution function (CDF) analyses, and using the MobiDB web-based tool, whereas potential functionality of intrinsic disorder was studied with the D2P2 resource and ANCHOR predictor of disorder-based binding sites, and the STRING tool was used to build the interactivity networks of the preeclampsia-related proteins. Peculiarities of the PIM-derived polar profile of the group of preeclampsia-related proteins were then compared with profiles of a group of lipoproteins, antimicrobial peptides, angiogenesis-related proteins, and the intrinsically disordered proteins. Our results showed a high graphical correlation between preeclampsia proteins, lipoproteins, and the angiogenesis proteins. We also showed that many preeclampsia-related proteins contain numerous functional disordered regions. Therefore, these bioinformatics results led us to assume that the preeclampsia proteins are highly associated with the lipoproteins group, and that some preeclampsia-related proteins contain significant amounts of functional disorders.

  20. Intrinsic Coupling Modes in Source-Reconstructed Electroencephalography

    PubMed Central

    Breakspear, Michael; Britz, Juliane; Boonstra, Tjeerd W.

    2014-01-01

    Abstract Intrinsic coupling of neuronal assemblies constitutes a key feature of ongoing brain activity, yielding the rich spatiotemporal patterns observed in neuroimaging data and putatively supporting cognitive processes. Intrinsic coupling has been investigated in electrophysiological recordings using two types of functional connectivity measures: amplitude and phase coupling. These two coupling modes differ in their likely causes and functions, and have been proposed to provide complementary insights into intrinsic neuronal interactions. Here, we investigate the relationship between amplitude and phase coupling in source-reconstructed electroencephalography (EEG). Volume conduction is a key obstacle for connectivity analysis in EEG—we therefore also test the envelope correlation of orthogonalized signals and the phase lag index. Functional connectivity between six seed source regions (bilateral visual, sensorimotor, and auditory cortices) and all other cortical voxels was computed. For all four measures, coupling between homologous sensory areas in both hemispheres was significantly higher than with other voxels at the same physical distance. The frequency of significant coupling differed between sensory areas: 10 Hz for visual, 30 Hz for auditory, and 40 Hz for sensorimotor cortices. By contrasting envelope correlations and phase locking values, we observed two distinct clusters of voxels showing a different relationship between amplitude and phase coupling. Large clusters contiguous to the seed regions showed an identity (1:1) relationship between amplitude and phase coupling, whereas a cluster located around the contralateral homologous regions showed higher phase than amplitude coupling. These results show a relationship between intrinsic coupling modes that is distinct from the effect of volume conduction. PMID:25230358

  1. Intrinsic Bistable Photonic Materials by Copper Colloid Formation in Silica

    DTIC Science & Technology

    1992-07-31

    Maximum 200 words) Eon implantation has been used to assemble planar thin films of metallic nanoclusters embedded in a dilectric. Gold and copper were...AND SUBTITLE S. FUNDING NUMBERS Intrinsic Bistable Photonic Materials by Copper Colloid C Formation in Silica DAALO3-9 IG-0028 / c. AUTHOR(S) Robert H...both found to produce nanosize metal clusters in silica. Both the size and size distribution of the metallic nanoclusters were characterized by

  2. Intrinsic Bistable Photonic Materials by Copper Colloid Formation in Silica.

    DTIC Science & Technology

    1992-07-31

    implantation has been used to assemble planar thin films of metallic nanoclusters embedded in a dilectric. Gold and copper were both found to produce nanosize...AND SUBTITLE S. FUNDING NUMBERS Intrinsic Bistable Photonic Materials by Copper Colloid Formation in Silica 6. AUTHOR(S) J Robert H. Magruder, III 7...metal clusters in silica. Both the size and size distribution of the metallic nanoclusters were characterized by transmission electron microscopy. The

  3. Miniaturized INtrinsic DISsolution Screening (MINDISS) assay for preformulation.

    PubMed

    Alsenz, Jochem; Haenel, Elisabeth; Anedda, Aline; Du Castel, Pauline; Cirelli, Giorgio

    2016-05-25

    This study describes a novel Miniaturized INtrinsic DISsolution Screening (MINDISS) assay for measuring disk intrinsic dissolution rates (DIDR). In MINDISS, compacted mini disks of drugs (2-5mg/disk) are prepared in custom made holders with a surface area of 3mm(2). Disks are immersed, pellet side down, into 0.35ml of appropriate dissolution media per well in 96-well microtiter plates, media are stirred and disk-holders are transferred to new wells after defined periods of time. After filtration, drug concentration in dissolution media is quantified by Ultra Performance Liquid Chromatography (UPLC) and solid state property of the disk is characterized by Raman spectroscopy. MINDISS was identified as an easy-to-use tool for rapid, parallel determination of DIDR of compounds that requires only small amounts of compound and of dissolution medium. Results obtained with marketed drugs in MINDISS correlate well with large scale DIDR methods and indicate that MINDISS can be used for (1) rank-ordering of compounds by intrinsic dissolution in late phase discovery and early development, (2) comparison of polymorphic forms and salts, (3) screening and selection of appropriate dissolution media, and (4) characterization of the intestinal release behavior of compounds along the gastro intestinal tract by changing biorelevant media during experiments.

  4. Intrinsic Valuation of Information in Decision Making under Uncertainty

    PubMed Central

    Bode, Stefan; Brydevall, Maja; Murawski, Carsten

    2016-01-01

    In a dynamic world, an accurate model of the environment is vital for survival, and agents ought regularly to seek out new information with which to update their world models. This aspect of behaviour is not captured well by classical theories of decision making, and the cognitive mechanisms of information seeking are poorly understood. In particular, it is not known whether information is valued only for its instrumental use, or whether humans also assign it a non-instrumental intrinsic value. To address this question, the present study assessed preference for non-instrumental information among 80 healthy participants in two experiments. Participants performed a novel information preference task in which they could choose to pay a monetary cost to receive advance information about the outcome of a monetary lottery. Importantly, acquiring information did not alter lottery outcome probabilities. We found that participants were willing to incur considerable monetary costs to acquire payoff-irrelevant information about the lottery outcome. This behaviour was well explained by a computational cognitive model in which information preference resulted from aversion to temporally prolonged uncertainty. These results strongly suggest that humans assign an intrinsic value to information in a manner inconsistent with normative accounts of decision making under uncertainty. This intrinsic value may be associated with adaptive behaviour in real-world environments by producing a bias towards exploratory and information-seeking behaviour. PMID:27416034

  5. Intrinsic connectivity networks within cerebellum and beyond in eating disorders.

    PubMed

    Amianto, F; D'Agata, F; Lavagnino, L; Caroppo, P; Abbate-Daga, G; Righi, D; Scarone, S; Bergui, M; Mortara, P; Fassino, S

    2013-10-01

    Cerebellum seems to have a role both in feeding behavior and emotion regulation; therefore, it is a region that warrants further neuroimaging studies in eating disorders, severe conditions that determine a significant impairment in the physical and psychological domain. The aim of this study was to examine the cerebellum intrinsic connectivity during functional magnetic resonance imaging resting state in anorexia nervosa (AN), bulimia nervosa (BN), and healthy controls (CN). Resting state brain activity was decomposed into intrinsic connectivity networks (ICNs) using group spatial independent component analysis on the resting blood oxygenation level dependent time courses of 12 AN, 12 BN, and 10 CN. We extracted the cerebellar ICN and compared it between groups. Intrinsic connectivity within the cerebellar network showed some common alterations in eating disordered compared to healthy subjects (e.g., a greater connectivity with insulae, vermis, and paravermis and a lesser connectivity with parietal lobe); AN and BN patients were characterized by some peculiar alterations in connectivity patterns (e.g., greater connectivity with the insulae in AN compared to BN, greater connectivity with anterior cingulate cortex in BN compared to AN). Our data are consistent with the presence of different alterations in the cerebellar network in AN and BN patients that could be related to psychopathologic dimensions of eating disorders.

  6. Inhibitory control of correlated intrinsic variability in cortical networks

    PubMed Central

    Stringer, Carsen; Pachitariu, Marius; Steinmetz, Nicholas A; Okun, Michael; Bartho, Peter; Harris, Kenneth D; Sahani, Maneesh; Lesica, Nicholas A

    2016-01-01

    Cortical networks exhibit intrinsic dynamics that drive coordinated, large-scale fluctuations across neuronal populations and create noise correlations that impact sensory coding. To investigate the network-level mechanisms that underlie these dynamics, we developed novel computational techniques to fit a deterministic spiking network model directly to multi-neuron recordings from different rodent species, sensory modalities, and behavioral states. The model generated correlated variability without external noise and accurately reproduced the diverse activity patterns in our recordings. Analysis of the model parameters suggested that differences in noise correlations across recordings were due primarily to differences in the strength of feedback inhibition. Further analysis of our recordings confirmed that putative inhibitory neurons were indeed more active during desynchronized cortical states with weak noise correlations. Our results demonstrate that network models with intrinsically-generated variability can accurately reproduce the activity patterns observed in multi-neuron recordings and suggest that inhibition modulates the interactions between intrinsic dynamics and sensory inputs to control the strength of noise correlations. DOI: http://dx.doi.org/10.7554/eLife.19695.001 PMID:27926356

  7. Mechanism of the intrinsic arginine finger in heterotrimeric G proteins

    PubMed Central

    Mann, Daniel; Teuber, Christian; Tennigkeit, Stefan A.; Schröter, Grit; Gerwert, Klaus

    2016-01-01

    Heterotrimeric G proteins are crucial molecular switches that maintain a large number of physiological processes in cells. The signal is encoded into surface alterations of the Gα subunit that carries GTP in its active state and GDP in its inactive state. The ability of the Gα subunit to hydrolyze GTP is essential for signal termination. Regulator of G protein signaling (RGS) proteins accelerates this process. A key player in this catalyzed reaction is an arginine residue, Arg178 in Gαi1, which is already an intrinsic part of the catalytic center in Gα in contrast to small GTPases, at which the corresponding GTPase-activating protein (GAP) provides the arginine “finger.” We applied time-resolved FTIR spectroscopy in combination with isotopic labeling and site-directed mutagenesis to reveal the molecular mechanism, especially of the role of Arg178 in the intrinsic Gαi1 mechanism and the RGS4-catalyzed mechanism. Complementary biomolecular simulations (molecular mechanics with molecular dynamics and coupled quantum mechanics/molecular mechanics) were performed. Our findings show that Arg178 is bound to γ-GTP for the intrinsic Gαi1 mechanism and pushed toward a bidentate α-γ-GTP coordination for the Gαi1·RGS4 mechanism. This movement induces a charge shift toward β-GTP, increases the planarity of γ-GTP, and thereby catalyzes the hydrolysis. PMID:27911799

  8. How the cosmic web induces intrinsic alignments of galaxies

    NASA Astrophysics Data System (ADS)

    Codis, S.; Dubois, Y.; Pichon, C.; Devriendt, J.; Slyz, A.

    2016-10-01

    Intrinsic alignments are believed to be a major source of systematics for future generation of weak gravitational lensing surveys like Euclid or LSST. Direct measurements of the alignment of the projected light distribution of galaxies in wide field imaging data seem to agree on a contamination at a level of a few per cent of the shear correlation functions, although the amplitude of the effect depends on the population of galaxies considered. Given this dependency, it is difficult to use dark matter-only simulations as the sole resource to predict and control intrinsic alignments. We report here estimates on the level of intrinsic alignment in the cosmological hydrodynamical simulation Horizon-AGN that could be a major source of systematic errors in weak gravitational lensing measurements. In particular, assuming that the spin of galaxies is a good proxy for their ellipticity, we show how those spins are spatially correlated and how they couple to the tidal field in which they are embedded. We will also present theoretical calculations that illustrate and qualitatively explain the observed signals.

  9. Magnetic Fluctuation-Driven Intrinsic Flow in a Toroidal Plasma

    NASA Astrophysics Data System (ADS)

    Brower, D. L.; Ding, W. X.; Lin, L.; Almagri, A. F.; den Hartog, D. J.; Sarff, J. S.

    2012-10-01

    Magnetic fluctuations have been long observed in various magnetic confinement configurations. These perturbations may arise naturally from plasma instabilities such as tearing modes and energetic particle driven modes, but they can also be externally imposed by error fields or external magnetic coils. It is commonly observed that large MHD modes lead to plasma locking (no rotation) due to torque produced by eddy currents on the wall, and it is predicted that stochastic field induces flow damping where the radial electric field is reduced. Flow generation is of great importance to fusion plasma research, especially low-torque devices like ITER, as it can act to improve performance. Here we describe new measurements in the MST reversed field pinch (RFP) showing that the coherent interaction of magnetic and particle density fluctuations can produce a turbulent fluctuation-induced kinetic force, which acts to drive intrinsic plasma rotation. Key observations include; (1) the average kinetic force resulting from density fluctuations, ˜ 0.5 N/m^3, is comparable to the intrinsic flow acceleration, and (2) between sawtooth crashes, the spatial distribution of the kinetic force is directed to create a sheared parallel flow profile that is consistent with the measured flow profile in direction and amplitude, suggesting the kinetic force is responsible for intrinsic plasma rotation.

  10. In Search of the Neural Circuits of Intrinsic Motivation

    PubMed Central

    Kaplan, Frederic; Oudeyer, Pierre-Yves

    2007-01-01

    Children seem to acquire new know-how in a continuous and open-ended manner. In this paper, we hypothesize that an intrinsic motivation to progress in learning is at the origins of the remarkable structure of children's developmental trajectories. In this view, children engage in exploratory and playful activities for their own sake, not as steps toward other extrinsic goals. The central hypothesis of this paper is that intrinsically motivating activities correspond to expected decrease in prediction error. This motivation system pushes the infant to avoid both predictable and unpredictable situations in order to focus on the ones that are expected to maximize progress in learning. Based on a computational model and a series of robotic experiments, we show how this principle can lead to organized sequences of behavior of increasing complexity characteristic of several behavioral and developmental patterns observed in humans. We then discuss the putative circuitry underlying such an intrinsic motivation system in the brain and formulate two novel hypotheses. The first one is that tonic dopamine acts as a learning progress signal. The second is that this progress signal is directly computed through a hierarchy of microcortical circuits that act both as prediction and metaprediction systems. PMID:18982131

  11. Sensory Deprivation Triggers Synaptic and Intrinsic Plasticity in the Hippocampus.

    PubMed

    Milshtein-Parush, Hila; Frere, Samuel; Regev, Limor; Lahav, Coren; Benbenishty, Amit; Ben-Eliyahu, Shamgar; Goshen, Inbal; Slutsky, Inna

    2017-04-12

    Hippocampus, a temporal lobe structure involved in learning and memory, receives information from all sensory modalities. Despite extensive research on the role of sensory experience in cortical map plasticity, little is known about whether and how sensory experience regulates functioning of the hippocampal circuits. Here, we show that 9 ± 2 days of whisker deprivation during early mouse development depresses activity of CA3 pyramidal neurons by several principal mechanisms: decrease in release probability, increase in the fraction of silent synapses, and reduction in intrinsic excitability. As a result of deprivation-induced presynaptic inhibition, CA3-CA1 synaptic facilitation was augmented at high frequencies, shifting filtering properties of synapses. The changes in the AMPA-mediated synaptic transmission were accompanied by an increase in NR2B-containing NMDA receptors and a reduction in the AMPA/NMDA ratio. The observed reconfiguration of the CA3-CA1 connections may represent a homeostatic adaptation to augmentation in synaptic activity during the initial deprivation phase. In adult mice, tactile disuse diminished intrinsic excitability without altering synaptic facilitation. We suggest that sensory experience regulates computations performed by the hippocampus by tuning its synaptic and intrinsic characteristics.

  12. Intrinsic Fluctuations, Robustness and Tunability in Signaling Cycles.

    NASA Astrophysics Data System (ADS)

    Levine, Joseph; Kueh, Hao Yuan; Mirny, Leonid

    2006-03-01

    Covalent modification cycles (e.g. phosphorylation) underlie most cellular signaling. Low molecular copy number, arising from compartmental segregation and slow diffusion between compartments, potentially renders these cycles vulnerable to intrinsic chemical fluctuations. How can a cell operate reliably in the presence of this inherent stochasticity? How do changes in extrinsic parameters lead to variability of response? Can cells exploit these parameters to tune cycles to different ranges of stimuli? We study the dynamics of an isolated phosphorylation cycle. Our model shows that the cycle transmits information reliably if it is tuned to an optimal parameter range, in spite of intrinsic fluctuations and even for small input signal amplitudes. At the same time, the cycle is sensitive to changes in the concentration and activity of kinases and phosphatases. This sensitivity can lead to significant cell-to-cell response variability Our results show that signaling cycles possess a surprising combination of robustness and tunability. This combination makes them ubiquitous in eukaryotic signaling, optimizing signaling in the presence of fluctuations using their inherent flexibility. On the other hand, cycles tuned to suppress intrinsic fluctuations can be fragile to changes in the number and activity of kinases and phosphatases. Such trade-offs in robustness to fluctuations can influence the evolution of signaling cascades, making them the weakest links in cellular circuits.

  13. An interatomic pair potential with tunable intrinsic ductility

    NASA Astrophysics Data System (ADS)

    Rajan, V. P.; Warner, D. H.; Curtin, W. A.

    2016-02-01

    A family of interatomic potentials is constructed for which the intrinsic ductility can be tuned systematically. Specifically, the elastic constants and critical energy release rate for Griffith cleavage, {{G}\\text{Ic}} , are held constant, while the critical energy release rate for dislocation emission, {{G}\\text{Ie}} , can be varied. This behavior is achieved by modifying a standard near-neighbor pair potential; the new potential is applicable to either 2D (hexagonal lattice) or 3D (FCC/HCP). Analytical expressions are provided for {{G}\\text{Ie}} and {{G}\\text{Ic}} , enabling a potential with a desired intrinsic ductility to be easily developed. Direct atomistic simulations are used to demonstrate that the new potentials control the intrinsic material ductility, i.e. crack tip dislocation emission versus brittle cleavage, under quasi-static loading. For the 2D potential, the mode I crack tip behavior can be tuned from brittle to ductile; for the 3D potential, such tuning is only possible for certain crack orientations. More generally, the new potentials are expected to be useful in a wide range of physical problems in which behavior is controlled by the ability of the material to nucleate dislocations, including problems involving crack tips, grain boundaries, contact and friction, and bi-material interfaces.

  14. Intrinsic Defect Ferromagnetism: The case of Hafnium Oxide

    NASA Astrophysics Data System (ADS)

    Das Pemmaraju, Chaitanya

    2005-03-01

    In view of the recent experimental reports of intrinsic ferromagnetism in Hafnium Oxide (HfO2) thin film systems ootnotetextM. Venkatesan, C. B. Fitzgerald, J. M. D. Coey Nature 430, 630 (2004) Brief Communications, we carried out first principles investigations to look for magnetic structure in HfO2 possibly brought about by the presence of small concentrations of intrinsic point defects. Ab initio electronic structure calculations using Density Functional Theory (DFT) show that isolated cation vacancy sites in HfO2 lead to the formation of high spin defect states which couple ferromagnetically to each other. Interestingly, these high spin states are observed in the low symmetry monoclinic and tetragonal phases while the highly symmetric cubic flourite phase exhibits a non-magnetic ground state. Detailed studies of the electronic structure of cation vacancies in the three crystalline phases of Hafnia show that symmetry leading to orbitally degenerate defect levels is not a pre-requsite for ferromagnetism and that the interplay between Kinetic, Coulomb and Exchange energy together with favourable coupling to the Crystalline environment can lead to high spin ferromagnetic ground states even in extreme low symmetry systems like monoclinic HfO2. These findings open up a much wider class of systems to the possibility of intrinsic defect ferromagnetism.

  15. Incremental learning of skill collections based on intrinsic motivation

    PubMed Central

    Metzen, Jan H.; Kirchner, Frank

    2013-01-01

    Life-long learning of reusable, versatile skills is a key prerequisite for embodied agents that act in a complex, dynamic environment and are faced with different tasks over their lifetime. We address the question of how an agent can learn useful skills efficiently during a developmental period, i.e., when no task is imposed on him and no external reward signal is provided. Learning of skills in a developmental period needs to be incremental and self-motivated. We propose a new incremental, task-independent skill discovery approach that is suited for continuous domains. Furthermore, the agent learns specific skills based on intrinsic motivation mechanisms that determine on which skills learning is focused at a given point in time. We evaluate the approach in a reinforcement learning setup in two continuous domains with complex dynamics. We show that an intrinsically motivated, skill learning agent outperforms an agent which learns task solutions from scratch. Furthermore, we compare different intrinsic motivation mechanisms and how efficiently they make use of the agent's developmental period. PMID:23898265

  16. Intrinsic Multi-Scale Dynamic Behaviors of Complex Financial Systems.

    PubMed

    Ouyang, Fang-Yan; Zheng, Bo; Jiang, Xiong-Fei

    2015-01-01

    The empirical mode decomposition is applied to analyze the intrinsic multi-scale dynamic behaviors of complex financial systems. In this approach, the time series of the price returns of each stock is decomposed into a small number of intrinsic mode functions, which represent the price motion from high frequency to low frequency. These intrinsic mode functions are then grouped into three modes, i.e., the fast mode, medium mode and slow mode. The probability distribution of returns and auto-correlation of volatilities for the fast and medium modes exhibit similar behaviors as those of the full time series, i.e., these characteristics are rather robust in multi time scale. However, the cross-correlation between individual stocks and the return-volatility correlation are time scale dependent. The structure of business sectors is mainly governed by the fast mode when returns are sampled at a couple of days, while by the medium mode when returns are sampled at dozens of days. More importantly, the leverage and anti-leverage effects are dominated by the medium mode.

  17. Mechanism of the intrinsic arginine finger in heterotrimeric G proteins.

    PubMed

    Mann, Daniel; Teuber, Christian; Tennigkeit, Stefan A; Schröter, Grit; Gerwert, Klaus; Kötting, Carsten

    2016-12-13

    Heterotrimeric G proteins are crucial molecular switches that maintain a large number of physiological processes in cells. The signal is encoded into surface alterations of the Gα subunit that carries GTP in its active state and GDP in its inactive state. The ability of the Gα subunit to hydrolyze GTP is essential for signal termination. Regulator of G protein signaling (RGS) proteins accelerates this process. A key player in this catalyzed reaction is an arginine residue, Arg178 in Gαi1, which is already an intrinsic part of the catalytic center in Gα in contrast to small GTPases, at which the corresponding GTPase-activating protein (GAP) provides the arginine "finger." We applied time-resolved FTIR spectroscopy in combination with isotopic labeling and site-directed mutagenesis to reveal the molecular mechanism, especially of the role of Arg178 in the intrinsic Gαi1 mechanism and the RGS4-catalyzed mechanism. Complementary biomolecular simulations (molecular mechanics with molecular dynamics and coupled quantum mechanics/molecular mechanics) were performed. Our findings show that Arg178 is bound to γ-GTP for the intrinsic Gαi1 mechanism and pushed toward a bidentate α-γ-GTP coordination for the Gαi1·RGS4 mechanism. This movement induces a charge shift toward β-GTP, increases the planarity of γ-GTP, and thereby catalyzes the hydrolysis.

  18. Intrinsic Valuation of Information in Decision Making under Uncertainty.

    PubMed

    Bennett, Daniel; Bode, Stefan; Brydevall, Maja; Warren, Hayley; Murawski, Carsten

    2016-07-01

    In a dynamic world, an accurate model of the environment is vital for survival, and agents ought regularly to seek out new information with which to update their world models. This aspect of behaviour is not captured well by classical theories of decision making, and the cognitive mechanisms of information seeking are poorly understood. In particular, it is not known whether information is valued only for its instrumental use, or whether humans also assign it a non-instrumental intrinsic value. To address this question, the present study assessed preference for non-instrumental information among 80 healthy participants in two experiments. Participants performed a novel information preference task in which they could choose to pay a monetary cost to receive advance information about the outcome of a monetary lottery. Importantly, acquiring information did not alter lottery outcome probabilities. We found that participants were willing to incur considerable monetary costs to acquire payoff-irrelevant information about the lottery outcome. This behaviour was well explained by a computational cognitive model in which information preference resulted from aversion to temporally prolonged uncertainty. These results strongly suggest that humans assign an intrinsic value to information in a manner inconsistent with normative accounts of decision making under uncertainty. This intrinsic value may be associated with adaptive behaviour in real-world environments by producing a bias towards exploratory and information-seeking behaviour.

  19. Dissociable Intrinsic Connectivity Networks for Salience Processing and Executive Control

    PubMed Central

    Seeley, William W.; Menon, Vinod; Schatzberg, Alan F.; Keller, Jennifer; Glover, Gary H.; Kenna, Heather; Reiss, Allan L.; Greicius, Michael D.

    2008-01-01

    Variations in neural circuitry, inherited or acquired, may underlie important individual differences in thought, feeling, and action patterns. Here, we used task-free connectivity analyses to isolate and characterize two distinct networks typically coactivated during functional MRI tasks. We identified a “salience network,” anchored by dorsal anterior cingulate (dACC) and orbital frontoinsular cortices with robust connectivity to subcortical and limbic structures, and an “executive-control network” that links dorsolateral frontal and parietal neocortices. These intrinsic connectivity networks showed dissociable correlations with functions measured outside the scanner. Prescan anxiety ratings correlated with intrinsic functional connectivity of the dACC node of the salience network, but with no region in the executive-control network, whereas executive task performance correlated with lateral parietal nodes of the executive-control network, but with no region in the salience network. Our findings suggest that task-free analysis of intrinsic connectivity networks may help elucidate the neural architectures that support fundamental aspects of human behavior. PMID:17329432

  20. Characterizing the intrinsic correlations of scale-free networks

    NASA Astrophysics Data System (ADS)

    de Brito, J. B.; Sampaio Filho, C. I. N.; Moreira, A. A.; Andrade, J. S.

    2016-08-01

    When studying topological or dynamical properties of random scale-free networks, it is tacitly assumed that degree-degree correlations are not present. However, simple constraints, such as the absence of multiple edges and self-loops, can give rise to intrinsic correlations in these structures. In the same way that Fermionic correlations in thermodynamic systems are relevant only in the limit of low temperature, the intrinsic correlations in scale-free networks are relevant only when the extreme values for the degrees grow faster than the square root of the network size. In this situation, these correlations can significantly affect the dependence of the average degree of the nearest neighbors of a given vertex on this vertices degree. Here, we introduce an analytical approach that is capable to predict the functional form of this property. Moreover, our results indicate that random scale-free network models are not self-averaging, that is, the second moment of their degree distribution may vary orders of magnitude among different realizations. Finally, we argue that the intrinsic correlations investigated here may have profound impact on the critical properties of random scale-free networks.

  1. An intrinsic mechanism of secreted protein aging and turnover.

    PubMed

    Yang, Won Ho; Aziz, Peter V; Heithoff, Douglas M; Mahan, Michael J; Smith, Jeffrey W; Marth, Jamey D

    2015-11-03

    The composition and functions of the secreted proteome are controlled by the life spans of different proteins. However, unlike intracellular protein fate, intrinsic factors determining secreted protein aging and turnover have not been identified and characterized. Almost all secreted proteins are posttranslationally modified with the covalent attachment of N-glycans. We have discovered an intrinsic mechanism of secreted protein aging and turnover linked to the stepwise elimination of saccharides attached to the termini of N-glycans. Endogenous glycosidases, including neuraminidase 1 (Neu1), neuraminidase 3 (Neu3), beta-galactosidase 1 (Glb1), and hexosaminidase B (HexB), possess hydrolytic activities that temporally remodel N-glycan structures, progressively exposing different saccharides with increased protein age. Subsequently, endocytic lectins with distinct binding specificities, including the Ashwell-Morell receptor, integrin αM, and macrophage mannose receptor, are engaged in N-glycan ligand recognition and the turnover of secreted proteins. Glycosidase inhibition and lectin deficiencies increased protein life spans and abundance, and the basal rate of N-glycan remodeling varied among distinct proteins, accounting for differences in their life spans. This intrinsic multifactorial mechanism of secreted protein aging and turnover contributes to health and the outcomes of disease.

  2. An intrinsic mechanism of secreted protein aging and turnover

    PubMed Central

    Yang, Won Ho; Aziz, Peter V.; Heithoff, Douglas M.; Mahan, Michael J.; Smith, Jeffrey W.; Marth, Jamey D.

    2015-01-01

    The composition and functions of the secreted proteome are controlled by the life spans of different proteins. However, unlike intracellular protein fate, intrinsic factors determining secreted protein aging and turnover have not been identified and characterized. Almost all secreted proteins are posttranslationally modified with the covalent attachment of N-glycans. We have discovered an intrinsic mechanism of secreted protein aging and turnover linked to the stepwise elimination of saccharides attached to the termini of N-glycans. Endogenous glycosidases, including neuraminidase 1 (Neu1), neuraminidase 3 (Neu3), beta-galactosidase 1 (Glb1), and hexosaminidase B (HexB), possess hydrolytic activities that temporally remodel N-glycan structures, progressively exposing different saccharides with increased protein age. Subsequently, endocytic lectins with distinct binding specificities, including the Ashwell–Morell receptor, integrin αM, and macrophage mannose receptor, are engaged in N-glycan ligand recognition and the turnover of secreted proteins. Glycosidase inhibition and lectin deficiencies increased protein life spans and abundance, and the basal rate of N-glycan remodeling varied among distinct proteins, accounting for differences in their life spans. This intrinsic multifactorial mechanism of secreted protein aging and turnover contributes to health and the outcomes of disease. PMID:26489654

  3. Intrinsic ethics regarding integrated assessment models for climate management.

    PubMed

    Schienke, Erich W; Baum, Seth D; Tuana, Nancy; Davis, Kenneth J; Keller, Klaus

    2011-09-01

    In this essay we develop and argue for the adoption of a more comprehensive model of research ethics than is included within current conceptions of responsible conduct of research (RCR). We argue that our model, which we label the ethical dimensions of scientific research (EDSR), is a more comprehensive approach to encouraging ethically responsible scientific research compared to the currently typically adopted approach in RCR training. This essay focuses on developing a pedagogical approach that enables scientists to better understand and appreciate one important component of this model, what we call intrinsic ethics. Intrinsic ethical issues arise when values and ethical assumptions are embedded within scientific findings and analytical methods. Through a close examination of a case study and its application in teaching, namely, evaluation of climate change integrated assessment models, this paper develops a method and case for including intrinsic ethics within research ethics training to provide scientists with a comprehensive understanding and appreciation of the critical role of values and ethical choices in the production of research outcomes.

  4. INTRINSIC DOSIMETRY: A POTENTIAL NEW TOOL FOR NUCLEAR FORENSICS INVESTIGATIONS

    SciTech Connect

    Clark, Richard A.; Miller, Steven D.; Robertson, Dave J.; Gregg, Roger A.; Murphy, Mark K.; Schwantes, Jon M.

    2010-08-11

    Thermoluminescence (TL) dosimetry was used to measure dose effects on the raw stock material of borosilicate container glass from different geographical locations. Effects were studied at times up to 60 days post-irradiation at doses from 0.15 to 20 Gy. The minimum detectable dose using this technique was estimated to be 0.15 Gy which is roughly equivalent to a 24 hr irradiation 1 cm from a 50 ng source of 60Co. Two peaks were identified in the TL glow curve, a relatively unstable peak around 125°C and a more stable peak around 225°C. Differences in TL glow curve shape and intensity were also observed for the glasses from different geographical origins. We investigate radiation induced defects in glass to further develop the technique of intrinsic dosimetry–the measurement of the total absorbed dose received by the walls of a container holding radioactive material. Intrinsic dosimetry is intended to be used as an interrogation tool to provide enhanced pathway information on interdicted or newly discovered waste containers of unknown origin or history by considering the total absorbed dose received by a container in tandem with the physical characteristics of the radioactive material housed within that container. One hypothetical scenario is presented to illustrate the application of intrinsic dosimetry to waste management and nuclear forensics.

  5. A case study of the intrinsic bioremediation of petroleum hydrocarbons

    SciTech Connect

    Barker, G.W.; Raterman, K.T.; Fisher, J.B.; Corgan, J.M.

    1995-12-31

    Condensate liquids have been found to contaminate soil and groundwater at two gas production sites in the Denver Basin operated by Amoco Production Co. These sites have been closely monitored since July 1993 to determine whether intrinsic aerobic or anaerobic bioremediation of hydrocarbons occurs at a sufficient rate and to an adequate endpoint to support a no-intervention decision. Groundwater monitoring and analysis of soil cores suggest that intrinsic bioremediation is occurring at these sites by multiple pathways including aerobic oxidation, Fe{sup 3+} reduction, and sulfate reduction. In laboratory experiments the addition of gas condensate hydrocarbons to saturated soil from the gas production site stimulated sulfate reduction under anaerobic and oxygen-limiting conditions, and nitrate and Fe{sup 3+} reduction under oxygen-limiting conditions, compared to biotic controls that lacked hydrocarbon and sterile controls. The sulfate reduction corresponded to a reduction in the amount of toluene relative to other hydrocarbons. These results confirmed that subsurface soils at the gas production site have the potential for intrinsic bioremediation of hydrocarbons.

  6. Relationship between placental traits and maternal intrinsic factors in sheep.

    PubMed

    Ocak, S; Ogun, S; Onder, H

    2013-06-01

    The relationship between maternal intrinsic factors and placental traits was investigated on three Southern Mediterranean breed of sheep; Cukurova Assaf (CA), Cukurova (C) and Cukurova Meat Sheep (CMS). The effect of parity and birth type were also considered in the study as a potential influencing factor. Our hypothesis was to show that while differences in placental traits between breed, parity and birth type affected lamb condition and survivability, its correlation to maternal intrinsic behavioral factors may also be a strong indicator. The study found breed related differences of maternal behavioral factors and also showed significant correlation of these behavioral patterns to various placental traits. It confirmed earlier findings that parity played a major role in the refinement of these behavioral patterns. Significant differences in birth weight (P<0.05), placental weight (P<0.05), number of cotyledons (P<0.01) and cotyledon length (P<0.05) was seen between breeds. Cotyledon weight (P<0.05), width (P<0.01) and length (P<0.05) were found to differ by parity. Breed and parity interaction significantly influenced cotyledon quantity. While we detected breed specific differences in relation to maternal intrinsic factors we also noticed significant variance within breeds to these behavioral patterns when linked to placental traits. Further study is required on the correlation between placental traits and postnatal behavior on not just the ewes but also on their lambs. This could have a significant bearing on how producers manage and maximize lamb survivability.

  7. Intrinsic Multi-Scale Dynamic Behaviors of Complex Financial Systems

    PubMed Central

    Ouyang, Fang-Yan; Zheng, Bo; Jiang, Xiong-Fei

    2015-01-01

    The empirical mode decomposition is applied to analyze the intrinsic multi-scale dynamic behaviors of complex financial systems. In this approach, the time series of the price returns of each stock is decomposed into a small number of intrinsic mode functions, which represent the price motion from high frequency to low frequency. These intrinsic mode functions are then grouped into three modes, i.e., the fast mode, medium mode and slow mode. The probability distribution of returns and auto-correlation of volatilities for the fast and medium modes exhibit similar behaviors as those of the full time series, i.e., these characteristics are rather robust in multi time scale. However, the cross-correlation between individual stocks and the return-volatility correlation are time scale dependent. The structure of business sectors is mainly governed by the fast mode when returns are sampled at a couple of days, while by the medium mode when returns are sampled at dozens of days. More importantly, the leverage and anti-leverage effects are dominated by the medium mode. PMID:26427063

  8. Intrinsic low-frequency variability of the Gulf Stream

    NASA Astrophysics Data System (ADS)

    Quattrocchi, G.; Pierini, S.; Dijkstra, H. A.

    2012-03-01

    In this paper a process study aimed at analyzing the low-frequency variability of intrinsically oceanic origin of the Gulf Stream (GS) and GS extension (GSE) is presented. An eddy-permitting reduced-gravity nonlinear shallow water model is implemented in an idealized North Atlantic Ocean, with schematic boundaries including the essential geometric features of the coastline and a realistic zonal basin width at all latitudes. The forcing is provided by a time-independent climatological surface wind stress obtained from 41 years of monthly ECMWF fields. The model response yields strong intrinsic low-frequency fluctuations on the interannual to decadal time scales. The modelled time-averaged GS/GSE flows are found to exhibit several features that can also be deduced from satellite altimeter data, such as the Florida Current seaward deflection, the GS separation at Cape Hatteras, and the overall structure of the GSE. The intrinsic low-frequency variability yields two preferred states of the GSE differing in latitudinal location that also have their counterpart in the altimeter data. A preliminary analysis of the variability in terms of dynamical systems theory is carried out by using the lateral eddy viscosity as the control parameter. A complex transition sequence from a steady state to irregular low-frequency variability emerges, in which Hopf and global bifurcations can be identified.

  9. Intrinsic laser-induced breakdown of silicate glasses

    NASA Astrophysics Data System (ADS)

    Glebov, Leonid B.

    2002-03-01

    This paper is a survey of experimental results in laser- induced damage observed mainly at State Optical Institute (St. Petersburg, Russia; at School of Optics/CREOL (Orlando, FL) which expounds conditions of observation of an intrinsic breakdown of high-purity silicate glasses and proposes the general idea of its mechanism. It is shown that the surface laser-induced breakdown of dielectrics is resulted from photo- and thermo-ionization of surface defects but not from interaction of laser radiation with dielectric material itself. Conditions of thermal ionization of the volume of dielectric materials are determined in dependence on features of absorption of material and temporal features of laser radiation. Statistical properties of laser-induced breakdown of high-purity glasses are caused by statistical properties of laser radiation while the breakdown itself is a deterministic process. Elimination of impact of self-focusing on the results of the breakdown threshold measurements is observed if the spot size of laser radiation in focal plane is less than the wavelength. No photoionization of glass matrix is detected before laser- induced breakdown, and there is no effect of photoionization of impurities and defects on intrinsic breakdown. A mechanism of intrinsic laser-induced breakdown is proposed which is a spasmodic transformation of the electronic level structure in a wide-bandgap dielectric caused by the electric field of laser radiation. This is a collective process converting a transparent material to the opaque state but not an individual process of any type of ionization.

  10. Anomalous Spectral Types and Intrinsic Colors of Young Stars

    NASA Astrophysics Data System (ADS)

    Pecaut, Mark J.

    2016-01-01

    We highlight differences in spectral types and intrinsic colors observed in pre-main sequence (pre-MS) stars. Spectral types of pre-MS stars are wavelength-dependent, with near-infrared spectra being 3-5 spectral sub-classes later than the spectral types determined from optical spectra. In addition, the intrinsic colors of young stars differ from that of main-sequence stars at a given spectral type. We caution observers to adopt optical spectral types over near-infrared types, since Hertzsprung-Russell (H-R) diagram positions derived from optical spectral types provide consistency between dynamical masses and theoretical evolutionary tracks. We also urge observers to deredden pre-MS stars with tabulations of intrinsic colors specifically constructed for young stars, since their unreddened colors differ from that of main sequence dwarfs. Otherwise, V-band extinctions as much as ~0.6 mag erroneously higher than the true extinction may result, which would introduce systematic errors in the H-R diagram positions and thus bias the inferred ages.

  11. Incremental learning of skill collections based on intrinsic motivation.

    PubMed

    Metzen, Jan H; Kirchner, Frank

    2013-01-01

    Life-long learning of reusable, versatile skills is a key prerequisite for embodied agents that act in a complex, dynamic environment and are faced with different tasks over their lifetime. We address the question of how an agent can learn useful skills efficiently during a developmental period, i.e., when no task is imposed on him and no external reward signal is provided. Learning of skills in a developmental period needs to be incremental and self-motivated. We propose a new incremental, task-independent skill discovery approach that is suited for continuous domains. Furthermore, the agent learns specific skills based on intrinsic motivation mechanisms that determine on which skills learning is focused at a given point in time. We evaluate the approach in a reinforcement learning setup in two continuous domains with complex dynamics. We show that an intrinsically motivated, skill learning agent outperforms an agent which learns task solutions from scratch. Furthermore, we compare different intrinsic motivation mechanisms and how efficiently they make use of the agent's developmental period.

  12. Downscaling Smooth Tomographic Models: Separating Intrinsic and Apparent Anisotropy

    NASA Astrophysics Data System (ADS)

    Bodin, Thomas; Capdeville, Yann; Romanowicz, Barbara

    2016-04-01

    In recent years, a number of tomographic models based on full waveform inversion have been published. Due to computational constraints, the fitted waveforms are low pass filtered, which results in an inability to map features smaller than half the shortest wavelength. However, these tomographic images are not a simple spatial average of the true model, but rather an effective, apparent, or equivalent model that provides a similar 'long-wave' data fit. For example, it can be shown that a series of horizontal isotropic layers will be seen by a 'long wave' as a smooth anisotropic medium. In this way, the observed anisotropy in tomographic models is a combination of intrinsic anisotropy produced by lattice-preferred orientation (LPO) of minerals, and apparent anisotropy resulting from the incapacity of mapping discontinuities. Interpretations of observed anisotropy (e.g. in terms of mantle flow) requires therefore the separation of its intrinsic and apparent components. The "up-scaling" relations that link elastic properties of a rapidly varying medium to elastic properties of the effective medium as seen by long waves are strongly non-linear and their inverse highly non-unique. That is, a smooth homogenized effective model is equivalent to a large number of models with discontinuities. In the 1D case, Capdeville et al (GJI, 2013) recently showed that a tomographic model which results from the inversion of low pass filtered waveforms is an homogenized model, i.e. the same as the model computed by upscaling the true model. Here we propose a stochastic method to sample the ensemble of layered models equivalent to a given tomographic profile. We use a transdimensional formulation where the number of layers is variable. Furthermore, each layer may be either isotropic (1 parameter) or intrinsically anisotropic (2 parameters). The parsimonious character of the Bayesian inversion gives preference to models with the least number of parameters (i.e. least number of layers, and

  13. Purdue University

    SciTech Connect

    Daly, P.; Grabowski, Z.; Mayer, R.H.

    1995-08-01

    The Purdue University group, including several thesis students, is working on a measurement of high-spin nuclear states at ATLAS. They use in-beam gamma-ray techniques to investigate several aspects of nuclear structure at high spin, testing the validity of shell-model calculations for high-spin-yrast states near Z = 50. The nuclei are produced via deep inelastic reactions, rather than with the more conventional fusion reactions. This technique allows the study of neutron-rich nuclei that cannot be studied by other means. The group is studying proton-rich nuclei with N{approximately}82 using the FMA and an electron spectrometer. Furthermore, D. Nisius is a Ph.D. student, resident at ANL, performing his thesis work under the supervision of R.V.F. Janssens.

  14. Intrinsically Motivated Reinforcement Learning: A Promising Framework for Developmental Robot Learning

    DTIC Science & Technology

    2005-01-01

    for intrinsically motivated reinforcement learning that strives to achieve broad competence in an environment in a task-nonspecific manner by...hierarchical learning, intrinsically motivated reinforcement learning is an obvious choice for organizing behavior in developmental robotics. We present

  15. Explicit solutions to the intrinsic generalization for the wave and sine-Gordon equations

    NASA Astrophysics Data System (ADS)

    Gu, Chaohao; Hu, Hesheng

    1993-09-01

    The Darboux matrix method is used to study intrinsic generalized wave equation and intrinsic generalized sine-Gordon equation which have been studied by Beals and Tenenblat. Explicit formulas for exact solutions are obtained.

  16. Role of intrinsic width in fragment momentum distributions in heavy ion collisions

    NASA Technical Reports Server (NTRS)

    Townsend, L. W.; Tripathi, R. K.; Khan, F.

    1994-01-01

    It is demonstrated that the intrinsic widths incorporating correlations in conjunction with dynamical contributions give better agreement with experiments for collisions in the energy range of 200 A MeV to 2.4 GeV than using only intrinsic widths without correlations. The sensitivity of the intrinsic width decreases with increasing projectile mass. A simple recipe for calculating intrinsic width correlations is presented.

  17. Intrinsical Randomness of Kolmogorov ℤ d-Actions on a Lebesgue Space

    NASA Astrophysics Data System (ADS)

    Courbage, M.; Kamiński, B.

    1999-11-01

    We introduce a concept of an intrinsically weak and strong randomness of a ℤ d -action on a Lebesgue space and we show that Kolmogorov ℤ d -actions are intrinsically weak random, and Bernoulli ℤ d -actions are intrinsically strong random.

  18. Assessing Individual-Level Factors Supporting Student Intrinsic Motivation in Online Discussions: A Qualitative Study

    ERIC Educational Resources Information Center

    Shroff, Ronnie H.; Vogel, Douglas R.; Coombes, John

    2008-01-01

    Research has established that intrinsic motivation has a positive effect on learning and academic achievement. However, little is known about the impact of different technology-supported learning activities on student intrinsic motivation or whether such learning activities significantly enhance student intrinsic motivation compared to traditional…

  19. Modeling Intrinsic Heterogeneity and Growth of Cancer Cells

    PubMed Central

    Greene, James M.; Levy, Doron; Fung, King L.; Silva de Souza, Paloma; Gottesman, Michael M.; Lavi, Orit

    2014-01-01

    Intratumoral heterogeneity has been found to be a major cause of drug resistance. Cell-to-cell variation increases as a result of cancer-related alterations, which are acquired by stochastic events and further induced by environmental signals. However, most cellular mechanisms include natural fluctuations that are closely regulated, and thus lead to asynchronization of the cells, which causes intrinsic heterogeneity in a given population. Here, we derive two novel mathematical models, a stochastic agent-based model and an integro-differential equation model, each of which describes the growth of cancer cells as a dynamic transition between proliferative and quiescent states. These models are designed to predict variations in growth as a function of the intrinsic heterogeneity emerging from the durations of the cell-cycle and apoptosis, and also include cellular density dependencies. By examining the role all parameters play in the evolution of intrinsic tumor heterogeneity, and the sensitivity of the population growth to parameter values, we show that the cell-cycle length has the most significant effect on the growth dynamics. In addition, we demonstrate that the agent-based model can be approximated well by the more computationally efficient integro-differential equations when the number of cells is large. This essential step in cancer growth modeling will allow us to revisit the mechanisms of multi-drug resistance by examining spatiotemporal differences of cell growth while administering a drug among the different sub-populations in a single tumor, as well as the evolution of those mechanisms as a function of the resistance level. PMID:25457229

  20. The Carnegie Supernova Project: Intrinsic colors of type Ia supernovae

    SciTech Connect

    Burns, Christopher R.; Persson, S. E.; Freedman, Wendy L.; Madore, Barry F.; Stritzinger, Maximilian; Contreras, Carlos; Phillips, M. M.; Hsiao, E. Y.; Boldt, Luis; Campillay, Abdo; Castellón, Sergio; Morrell, Nidia; Salgado, Francisco; Folatelli, Gaston; Suntzeff, Nicholas B.

    2014-07-01

    We present an updated analysis of the intrinsic colors of Type Ia supernova (SNe Ia) using the latest data release of the Carnegie Supernova Project. We introduce a new light-curve parameter very similar to stretch that is better suited for fast-declining events, and find that these peculiar types can be seen as extensions to the population of 'normal' SNe Ia. With a larger number of objects, an updated fit to the Lira relation is presented along with evidence for a dependence on the late-time slope of the B – V light-curves with stretch and color. Using the full wavelength range from u to H band, we place constraints on the reddening law for the sample as a whole and also for individual events/hosts based solely on the observed colors. The photometric data continue to favor low values of R{sub V} , though with large variations from event to event, indicating an intrinsic distribution. We confirm the findings of other groups that there appears to be a correlation between the derived reddening law, R{sub V} , and the color excess, E(B – V), such that larger E(B – V) tends to favor lower R{sub V} . The intrinsic u-band colors show a relatively large scatter that cannot be explained by variations in R{sub V} or by the Goobar power-law for circumstellar dust, but rather is correlated with spectroscopic features of the supernova and is therefore likely due to metallicity effects.

  1. Breast cancer stem cells and intrinsic subtypes: controversies rage on.

    PubMed

    Nakshatri, Harikrishna; Srour, Edward F; Badve, Sunil

    2009-01-01

    Heterogeneity is a well-documented phenomenon in breast cancer; one of the explanations for this phenomenon is the presence of cancer stem cells (CSCs) with the capacity to differentiate along divergent pathways. These CSCs undergo asymmetric and symmetric division resulting in both expansion of the stem cell pool and the production of morphologically and functionally distinct differentiated daughter cells. Breast cancer cells that express the cell surface molecule CD44 but lack the expression of CD24 have been described as CSCs. Breast cancer cells expressing elevated levels of Aldehyde Dehydrogenase 1 (ALDH1) are also described as CSCs with ALDH1+/CD44+/CD24- subpopulation displaying highest tumorigenic potential in NOD/SCID models. The CSC hypothesis for tumor heterogeneity raises three important questions. First, in unrelated gene expression studies, breast cancers have been classified to five intrinsic subtypes; luminal type A, luminal type B, basal type, ErbB2/HER2-positive and normal-like. Therefore, do these intrinsic subtypes of breast cancer have distinct CSCs of their own or are ALDH1+ or CD44+/CD24- cells common CSCs for all intrinsic subtypes? Secondly, do ALDH1+ or CD44+/CD24- CSCs originate from normal cells of same phenotype or can differentiated cancer cells acquire ALDH1 or CD44+/CD24- status due to mutagenic events? Third, do ALDH1+, ALDH1-, CD44+/CD24- and non-CD44+/CD24- cancer cells differ in their ability to metastasize and respond to chemotherapy? In this review, we present our views on these questions based on studies conducted by several laboratories including ours and present evidence for a strong association of CD44+/CD24- phenotype with basal-like or mesenchymal-like cancer cells.

  2. Analysis of Structured and Intrinsically Disordered Regions of Transmembrane Proteins

    PubMed Central

    Xue, Bin; Li, Liwei; Meroueh, Samy O.; Uversky, Vladimir N.; Dunker, A. Keith

    2010-01-01

    Integral membrane proteins display two major types of transmembrane structures, helical bundles and beta barrels. The main functional roles of transmembrane proteins are the transport of small molecules and cell signaling, and sometimes these two roles are coupled. For cytosolic, water-soluble proteins, signaling and regulatory functions are often carried out by intrinsically disordered regions. Our long range goal is to determine whether integral membrane proteins likewise often use disordered regions for signaling and regulation. Here we carried out a systematic bioinformatics investigation of intrinsically disordered regions obtained from integral membrane proteins for which crystal structures have been determined, and for which the intrinsic disorder was identified as missing electron density. We found 120 disorder-containing integral membrane proteins having a total of 33,675 residues, with 3209 of the residues distributed among 240 different disordered regions. These disordered regions were compared with those obtained from water-soluble proteins with regard to their amino acid compositional biases, and with regard to accuracies of various disorder predictors. The results of these analyses show that the disordered regions from helical bundle integral membrane proteins, those from beta barrel integral membrane proteins, and those from water soluble proteins all exhibit statistically distinct amino acid compositional biases. Despite these differences in composition, current algorithms make reasonably accurate predictions of disorder for these membrane proteins. Although the small size of the current data sets are limiting, these results suggest that developing new predictors that make use of data from disordered regions in helical bundles and beta barrels, especially as these datasets increase in size, will likely lead to significantly more accurate disorder predictions for these two classes of integral membrane proteins. PMID:19585006

  3. Relativistic Beaming and the Intrinsic Properties of Extragalactic Radio Jets

    NASA Astrophysics Data System (ADS)

    Cohen, M. H.; Lister, M. L.; Homan, D. C.; Kadler, M.; Kellermann, K. I.; Kovalev, Y. Y.; Vermeulen, R. C.

    2007-03-01

    Relations between the observed quantities for a beamed radio jet, which are the apparent transverse speed and the apparent luminosity (βapp, L), and the intrinsic quantities, which are the Lorentz factor and the intrinsic luminosity (γ, L0), are investigated. The inversion from measured to intrinsic values is not unique, but approximate limits to γ and L0 can be found using probability arguments. Roughly half the sources in a flux density-limited, beamed sample have a value of γ close to the measured value of βapp. The methods are applied to observations of 119 AGN jets made with the VLBA at 15 GHz during 1994-2002. The results strongly support the common relativistic beam model for an extragalactic radio jet. The (βapp, L) data are closely bounded by a theoretical envelope, an ``aspect'' curve for γ=32 and L0=1025 W Hz-1. This gives limits to the maximum values of γ and L0 in the sample: γmax~32, and L0,max~1026 W Hz-1. No sources with both high values of βapp and low values of L are observed. This is not the result of selection effects due to the observing limits, which are a flux density of S>0.5 Jy and an angular velocity of μ<4 mas yr-1. Many of the fastest quasars have a pattern Lorentz factor, γp, that is close to that of the beam, γb, but some of the slow quasars must have γp<<γb. Three of the 10 galaxies in the sample have a superluminal feature, with speeds up to βapp~6. The others are at most mildly relativistic. The galaxies are not off-axis versions of the powerful quasars, but Cygnus A might be an exception.

  4. Modeling intrinsic heterogeneity and growth of cancer cells.

    PubMed

    Greene, James M; Levy, Doron; Fung, King Leung; Souza, Paloma S; Gottesman, Michael M; Lavi, Orit

    2015-02-21

    Intratumoral heterogeneity has been found to be a major cause of drug resistance. Cell-to-cell variation increases as a result of cancer-related alterations, which are acquired by stochastic events and further induced by environmental signals. However, most cellular mechanisms include natural fluctuations that are closely regulated, and thus lead to asynchronization of the cells, which causes intrinsic heterogeneity in a given population. Here, we derive two novel mathematical models, a stochastic agent-based model and an integro-differential equation model, each of which describes the growth of cancer cells as a dynamic transition between proliferative and quiescent states. These models are designed to predict variations in growth as a function of the intrinsic heterogeneity emerging from the durations of the cell-cycle and apoptosis, and also include cellular density dependencies. By examining the role all parameters play in the evolution of intrinsic tumor heterogeneity, and the sensitivity of the population growth to parameter values, we show that the cell-cycle length has the most significant effect on the growth dynamics. In addition, we demonstrate that the agent-based model can be approximated well by the more computationally efficient integro-differential equations when the number of cells is large. This essential step in cancer growth modeling will allow us to revisit the mechanisms of multidrug resistance by examining spatiotemporal differences of cell growth while administering a drug among the different sub-populations in a single tumor, as well as the evolution of those mechanisms as a function of the resistance level.

  5. Spatially inhomogeneous and irrotational geometries admitting intrinsic conformal symmetries

    NASA Astrophysics Data System (ADS)

    Apostolopoulos, Pantelis S.

    2016-12-01

    "Diagonal" spatially inhomogeneous (SI) models are introduced under the assumption of the existence of (proper) intrinsic symmetries and can be seen, in some sense, as complementary to the Szekeres models. The structure of this class of spacetimes can be regarded as a generalization of the (twist-free) locally rotationally symmetric geometries without any global isometry containing, however, these models as special cases. We consider geometries where a six-dimensional algebra I C of intrinsic conformal vector fields (ICVFs) exists that acts on a two-dimensional (pseudo)-Riemannian manifold. Its members Xα —constituted of three intrinsic Killing vector fields and three proper and gradient ICVFs—and the specific form of the gravitational field are given explicitly. An interesting consequence, in contrast with the Szekeres models, is the immediate existence of conserved quantities along null geodesics. We check computationally that the magnetic part Ha b of the Weyl tensor vanishes, whereas the shear σa b and the electric part Ea b share a common eigenframe irrespective of the fluid interpretation of the models. A side result is the fact that the spacetimes are foliated by a set of conformally flat three-dimensional timelike slices when the anisotropy of the flux-free fluid is described only in terms of the three principal inhomogeneous "pressures" pα, or equivalently when the Ricci tensor shares the same basis of eigenvectors with σa b and Ea b. The conformal flatness also indicates that it is highly possible that a ten-dimensional algebra of ICVFs Ξ that acts on the three-dimensional timelike slices exists, enriching in that way the set of conserved quantities admitted by the SI models found in the present paper.

  6. Robust active binocular vision through intrinsically motivated learning.

    PubMed

    Lonini, Luca; Forestier, Sébastien; Teulière, Céline; Zhao, Yu; Shi, Bertram E; Triesch, Jochen

    2013-01-01

    The efficient coding hypothesis posits that sensory systems of animals strive to encode sensory signals efficiently by taking into account the redundancies in them. This principle has been very successful in explaining response properties of visual sensory neurons as adaptations to the statistics of natural images. Recently, we have begun to extend the efficient coding hypothesis to active perception through a form of intrinsically motivated learning: a sensory model learns an efficient code for the sensory signals while a reinforcement learner generates movements of the sense organs to improve the encoding of the signals. To this end, it receives an intrinsically generated reinforcement signal indicating how well the sensory model encodes the data. This approach has been tested in the context of binocular vison, leading to the autonomous development of disparity tuning and vergence control. Here we systematically investigate the robustness of the new approach in the context of a binocular vision system implemented on a robot. Robustness is an important aspect that reflects the ability of the system to deal with unmodeled disturbances or events, such as insults to the system that displace the stereo cameras. To demonstrate the robustness of our method and its ability to self-calibrate, we introduce various perturbations and test if and how the system recovers from them. We find that (1) the system can fully recover from a perturbation that can be compensated through the system's motor degrees of freedom, (2) performance degrades gracefully if the system cannot use its motor degrees of freedom to compensate for the perturbation, and (3) recovery from a perturbation is improved if both the sensory encoding and the behavior policy can adapt to the perturbation. Overall, this work demonstrates that our intrinsically motivated learning approach for efficient coding in active perception gives rise to a self-calibrating perceptual system of high robustness.

  7. Intrinsic irreversibility limits the efficiency of multidimensional molecular motors

    NASA Astrophysics Data System (ADS)

    Jack, M. W.; Tumlin, C.

    2016-05-01

    We consider the efficiency limits of Brownian motors able to extract work from the temperature difference between reservoirs or from external thermodynamic forces. These systems can operate in a variety of modes, including as isothermal engines, heat engines, refrigerators, and heat pumps. We derive analytical results showing that certain classes of multidimensional Brownian motor, including the Smoluchowski-Feynman ratchet, are unable to attain perfect efficiency (Carnot efficiency for heat engines). This demonstrates the presence of intrinsic irreversibilities in their operating mechanism. We present numerical simulations showing that in some cases the loss process that limits efficiency is associated with vortices in the probability current.

  8. Intrinsic Stability of the Smallest Possible Silver Nanotube

    NASA Astrophysics Data System (ADS)

    Autreto, P. A. S.; Lagos, M. J.; Sato, F.; Bettini, J.; Rocha, A. R.; Rodrigues, V.; Ugarte, D.; Galvao, D. S.

    2011-02-01

    Recently, Lagos et al. [Nature Nanotech. 4, 149 (2009)1748-338710.1038/nnano.2008.414] reported the discovery of the smallest possible Ag nanotube with a square cross section. Ab initio density functional theory calculations strongly support that the stability of these hollow structures is structurally intrinsic and not the result of contamination by light atoms. We also report the first experimental observation of the theoretically predicted corrugation of the hollow structure. Quantum conductance calculations predict a unique signature of 3.6G0 for this new family of nanotubes.

  9. Radius of gyration and intrinsic viscosity of polyelectrolyte solutions

    SciTech Connect

    Milas, M.; Borsali, R.; Rinaudo, M.

    1993-12-31

    Relatively low molecular weights polyelectrolytes (10{sup 4}-10{sup 6}) behave as worm-like chain when electrostatic repulsions are assumed to govern the excluded volume parameter. Under such conditions, predictions of chain expansion and effect of polyelectrolyte concentrations are made assuming that unperturbed dimensions could be obtained at infinite salt content. Experimental studies of an ionic polysaccharide, namely the Na-hyaluronate, were done and the values obtained for the radius of gyration as well as the intrinsic viscosity at different charge densities are in good agreement with the predictions.

  10. Intrinsic vs extrinsic motivation in learning disabled children.

    PubMed

    Reeve, P T; Loper, A B

    1983-08-01

    44 children identified as learning disabled were administered Harter's Scale of Intrinsic Versus Extrinsic Orientation in the Classroom. Scores were correlated with several indices of school behavior, standardized achievement test scores, report-card letter grades, and teachers' behavioral ratings. No consistent pattern of relationship was evidenced between the scale and academic achievement as assessed by standardized tests and report-card letter grades. However, a weak but statistically significant pattern of relationship (rs .24 to .33) was noted between two subscales of the Harter scale and teachers' behavioral ratings. Internality on these subscales tended to be associated with higher teachers' ratings.

  11. Real-time neuronal homeostasis by coordinating VGSC intrinsic properties.

    PubMed

    Ge, Rongjing; Chen, Na; Wang, Jin-Hui

    2009-09-25

    Homeostasis of internal environment and cellular metabolism ensures cells' functions to be stable in living organisms. Cellular homeostasis is believed to be maintained via feedback or feedforward manners. We report a novel mechanism that maintains neuronal homeostasis through coordinating the intrinsic properties of single molecules concurrently. Spike encoding and sodium channel dynamics at cortical neurons were studied by patch-clamp recording. Voltage-gated sodium channels set refractory period and threshold potential toward different directions to stabilize the energetic barrier for firing sequential action potentials. This neuronal homeostasis is not affected by intracellular Ca(2+) signals and membrane potentials. Real-time homeostasis maintains precise and reliable neuronal encoding without any destabilization.

  12. Representation of a gauge field via intrinsic "BRST" operator

    NASA Astrophysics Data System (ADS)

    Batalin, Igor A.; Lavrov, Peter M.

    2015-11-01

    We show that there exists a representation of a matrix-valued gauge field via intrinsic "BRST" operator assigned to matrix-valued generators of a gauge algebra. In this way, we reproduce the standard formulation of the ordinary Yang-Mills theory. In the case of a generating quasigroup/groupoid, we give a natural counterpart to the Yang-Mills action. The latter counterpart does also apply as to the most general case of an involution for matrix-valued gauge generators.

  13. Environmental preservation demand: Altruistic, bequest, and intrinsic motives

    SciTech Connect

    Whitehead, J.C.; Thompson, C.Y. )

    1993-01-01

    When the demand for environmental preservation is not explicitly revealed in markets, motivating attitudes toward environmental preservation become important. A survey approach allows revelation and measurement of demand for environmental preservation. Indices which measure the altruistic, bequest, intrinsic, and option to use motives and other attitudes are utilized as determinants in a model that measures the demand for environmental preservation. Demand is more likely with greater preservation motives. Preservation demand also depends on individual preferences for economic development, perceptions of affordability and responsibility for preservation of the wetlands. 17 refs., 3 tabs.

  14. Intrinsic Monitoring Using Behaviour Models in IPv6 Networks

    NASA Astrophysics Data System (ADS)

    Höfig, Edzard; Coşkun, Hakan

    In conventional networks, correlating path information to resource utilisation on the granularity of packets is a hard problem when using policy-based traffic handling schemes. We introduce a new approach termed ‘intrinsic monitoring’ which relies on the use of IPv6 extension headers in combination with formal behaviour models to gather resource information along a path. This allows a network monitoring system to delegate monitoring functionality to the network devices themselves, with the result of a drastic reduction in management traffic due to the increased autonomy of the monitoring system. As monitoring information travels in-band with the network traffic, path information remains perfectly accurate.

  15. The spin and flavor content of intrinsic sea quarks

    SciTech Connect

    Bo-Qiang Ma; Brodsky, S.J.

    1997-07-01

    The intrinsic quark-antiquark pairs generated by the minimal energy nonperturbative meson-baryon fluctuations in the nucleon sea provide a consistent framework for understanding a number of empirical anomalies observed in the deep inelastic quark-parton structure of nucleons: the flavor asymmetry of the nucleon sea implied by the violation of Gottfried sum rule, the proton spin problem implied by the violation of the Ellis-Jaffe sum rule, and the outstanding conflict between two different determinations of the strange quark sea in the nucleon.

  16. Sapphire-fiber-based intrinsic Fabry-Perot interferometer

    NASA Technical Reports Server (NTRS)

    Wang, Anbo; Gollapudi, Sridhar; Murphy, Kent A.; May, Russell G.; Claus, Richard O.

    1992-01-01

    A sapphire optical fiber intrinsic Fabry-Perot interferometric sensor is demonstrated. A length of multimode sapphire fiber that functions as a Fabry-Perot cavity is spliced to a silica single-mode fiber. The interferometric signals of this sensor are produced by the interference between the reflection from the silica-sapphire fiber splice and the reflection from the free end face of the sapphire fiber. This sensor has been demonstrated for temperature measurement. A resolution of 0.2 C has been obtained over a measurement range of 310 C to 976 C.

  17. Digital Fringe Counting for Intrinsic Fabry-Perot Interferometers

    NASA Technical Reports Server (NTRS)

    Froggatt, Mark; Melvin, Leland

    1996-01-01

    A digital dual-wavelength method of demodulating long (17cm) Intrinsic Fabry-Perot Interferometers (IFPI) is presented. The method builds upon previous techniques using small shifts in the lasing wavelength of a laser diode induced by changes in the driving current. The intensity of the light reflected from the IFPI is sampled at two carefully selected values of laser diode drive current. Digital logic is then used to count fringes based upon these two sampled values. Experimental verification of the method is described.

  18. Diffractive Higgs Production from Intrinsic Heavy Flavors in the Proton

    SciTech Connect

    Brodsky, Stanley J.; Kopeliovich, Boris; Schmidt, Ivan; Soffer, Jacques

    2006-03-31

    We propose a novel mechanism for exclusive diffractive Higgs production pp {yields} pHp in which the Higgs boson carries a significant fraction of the projectile proton momentum. This mechanism will provide a clear experimental signal for Higgs production due to the small background in this kinematic region. The key assumption underlying our analysis is the presence of intrinsic heavy flavor components of the proton bound state, whose existence at high light-cone momentum fraction x has growing experimental and theoretical support. We also discuss the implications of this picture for exclusive diffractive quarkonium and other channels.

  19. Intrinsic low thermal conductivity in weakly ionic rocksalt structures

    DOE PAGES

    Zhang, Yi; Dong, Jianjun; Kent, Paul R. C.; ...

    2015-07-06

    A fundamental challenge in thermoelectric (TE) material research is meeting the simultaneous requirements of high carrier mobility and low thermal conductivity. Simple crystal structures are ideal for maintaining high carrier mobility, but they usually have high thermal conductivity. In this paper, we show by first-principles lattice dynamics and Boltzmann transport calculations that weakly ionic rocksalt structures exhibit strong lattice anharmonicity and low acoustic-phonon group velocity, which combine to produce intrinsic low thermal conductivity. Finally, we unveil microscopic mechanisms that explain experimental observations and provide insights for TE material design and discovery.

  20. Intrinsic-cum-extrinsic normalization of formant data of vowels.

    PubMed

    T V, Ananthapadmanabha; A G, Ramakrishnan

    2016-11-01

    Using a known speaker-intrinsic normalization procedure, formant data are scaled by the reciprocal of the geometric mean of the first three formant frequencies. This reduces the influence of the talker but results in a distorted vowel space. The proposed speaker-extrinsic procedure re-scales the normalized values by the mean formant values of vowels. When tested on the formant data of vowels published by Peterson and Barney, the combined approach leads to well separated clusters by reducing the spread due to talkers. The proposed procedure performs better than two top-ranked normalization procedures based on the accuracy of vowel classification as the objective measure.

  1. Intrinsic and Scattering Seismic Attenuation in Southwestern Anatolia

    NASA Astrophysics Data System (ADS)

    Şahin, Ş.; Erduran, M.; Alptekin, Ö.; Çakir, Ö.

    2007-12-01

    The intrinsic dissipation and scattering attenuation in southwestern (SW) Anatolia, which is a tectonically active region, is studied using the coda waves. First the coda quality factor ( Q c ) assuming single scattering is estimated from the slope of the coda-wave amplitude decay. Then the Multiple Lapse Time Window (MLTW) analysis is performed with a uniform earth model. Three non-overlapping temporal data windows are used to calculate the scattered seismic energy densities against the source-receiver distances, which, in turn, are used to calculate separate estimates of the intrinsic and scattering factors. In order to explore the frequency dependency, the observed seismograms are band pass-filtered at the center frequencies of 0.75, 1.5, 3.0, 6.0 and 12.0. The scattering attenuation ( Q s -1) is found lower than the intrinsic attenuation ( Q i -1) at all frequencies except at 0.75 Hz where the opposite is observed. Overall the intrinsic attenuation dominates over the scattering attenuation in the SW Anatolia region. The integrated energy curves obtained for the first energy window (i.e., 0 15 s) are somewhat irregular with distance while the second (i.e., 15 30 s) and third (i.e., 30 45 s) data windows exhibit more regular change with distance at most frequencies. The seismic albedo B 0 is determined as 0.61 at 0.75 Hz and 0.34 at 12.0 Hz while the total attenuation factor denoted by L e -1 changes in the range 0.034 0.017. For the source-station range 20 180 km considered the scattering attenuation is found strongly frequency dependent given by the power law Q s -1 = 0.010* f -1.508. The same relations for Q i -1, Q t -1 (total), Q c -1 and {tilde{Q}}^{{- 1}}c (expected) hold as Q i -1 = 0.0090* f -1.17, Q t -1 = 0.019* f -1.31, Q c -1 = 0.008* f -0.84 and {tilde{Q}}c^{{- 1}} = 0.014*f^{{- 0.87}}, respectively. Compared to the other attenuation factors Q c -1 and {tilde{Q}}^{{- 1}}c are less dependent on the frequency.

  2. Intrinsic magnetic refrigeration of a single electron transistor

    SciTech Connect

    Ciccarelli, C.; Ferguson, A. J.; Campion, R. P.; Gallagher, B. L.

    2016-02-01

    In this work, we show that aluminium doped with low concentrations of magnetic impurities can be used to fabricate quantum devices with intrinsic cooling capabilities. We fabricate single electron transistors made of aluminium doped with 2% Mn by using a standard multi angle evaporation technique and show that the quantity of metal used to fabricate the devices generates enough cooling power to achieve a drop of 160 mK in the electron temperature at the base temperature of our cryostat (300 mK). The cooling mechanism is based on the magneto-caloric effect from the diluted Mn moments.

  3. Intrinsic fundamental frequency of vowels is moderated by regional dialect

    PubMed Central

    Jacewicz, Ewa; Fox, Robert Allen

    2015-01-01

    There has been a long-standing debate whether the intrinsic fundamental frequency (IF0) of vowels is an automatic consequence of articulation or whether it is independently controlled by speakers to perceptually enhance vowel contrasts along the height dimension. This paper provides evidence from regional variation in American English that IF0 difference between high and low vowels is, in part, controlled and varies across dialects. The sources of this F0 control are socio-cultural and cannot be attributed to differences in the vowel inventory size. The socially motivated enhancement was found only in prosodically prominent contexts. PMID:26520352

  4. Resonant tunneling and intrinsic bistability in twisted graphene structures

    NASA Astrophysics Data System (ADS)

    Rodriguez-Nieva, J. F.; Dresselhaus, M. S.; Levitov, L. S.

    2016-08-01

    We predict that vertical transport in heterostructures formed by twisted graphene layers can exhibit a unique bistability mechanism. Intrinsically bistable I -V characteristics arise from resonant tunneling and interlayer charge coupling, enabling multiple stable states in the sequential tunneling regime. We consider a simple trilayer architecture, with the outer layers acting as the source and drain and the middle layer floating. Under bias, the middle layer can be either resonant or nonresonant with the source and drain layers. The bistability is controlled by geometric device parameters easily tunable in experiments. The nanoscale architecture can enable uniquely fast switching times.

  5. Intrinsic and extrinsic motives for originally following a sport team and team identification.

    PubMed

    Wann, D L; Ensor, C L; Bilyeu, J K

    2001-10-01

    Research indicates that both highly and lowly identified fans are more likely to be intrinsically than extrinsically motivated and that highly identified fans have a particularly strong inclination for intrinsic motivation. The current investigation was designed to extend this work by examining the relationship between level of identification and one's intrinsic and extrinsic motives for originally following a sport team. Preference for intrinsic motives for originally following a team should be highest among those high on team identification. 88 participants completed questionnaires containing the Sport Spectator Identification Scale and items assessing their intrinsic and extrinsic motives for originally identifying with a team. Analyses provided clear support for the hypotheses.

  6. Folding propensity of intrinsically disordered proteins by osmotic stress

    DOE PAGES

    Mansouri, Amanda L.; Grese, Laura N.; Rowe, Erica L.; ...

    2016-10-11

    Proteins imparted with intrinsic disorder conduct a range of essential cellular functions. To better understand the folding and hydration properties of intrinsically disordered proteins (IDPs), we used osmotic stress to induce conformational changes in nuclear co-activator binding domain (NCBD) and activator for thyroid hormone and retinoid receptor (ACTR). Osmotic stress was applied by the addition of small and polymeric osmolytes, where we discovered that water contributions to NCBD folding always exceeded those for ACTR. Both NCBD and ACTR were found to gain a-helical structure with increasing osmotic stress, consistent with their folding upon NCBD/ACTR complex formation. Using small-angle neutron scatteringmore » (SANS), we further characterized NCBD structural changes with the osmolyte ethylene glycol. Here a large reduction in overall size initially occurred before substantial secondary structural change. In conclusion, by focusing on folding propensity, and linked hydration changes, we uncover new insights that may be important for how IDP folding contributes to binding.« less

  7. Intrinsically organized resting state networks in the human spinal cord

    PubMed Central

    Kong, Yazhuo; Eippert, Falk; Beckmann, Christian F.; Andersson, Jesper; Finsterbusch, Jürgen; Büchel, Christian; Tracey, Irene; Brooks, Jonathan C. W.

    2014-01-01

    Spontaneous fluctuations in functional magnetic resonance imaging (fMRI) signals of the brain have repeatedly been observed when no task or external stimulation is present. These fluctuations likely reflect baseline neuronal activity of the brain and correspond to functionally relevant resting-state networks (RSN). It is not known however, whether intrinsically organized and spatially circumscribed RSNs also exist in the spinal cord, the brain’s principal sensorimotor interface with the body. Here, we use recent advances in spinal fMRI methodology and independent component analysis to answer this question in healthy human volunteers. We identified spatially distinct RSNs in the human spinal cord that were clearly separated into dorsal and ventral components, mirroring the functional neuroanatomy of the spinal cord and likely reflecting sensory and motor processing. Interestingly, dorsal (sensory) RSNs were separated into right and left components, presumably related to ongoing hemibody processing of somatosensory information, whereas ventral (motor) RSNs were bilateral, possibly related to commissural interneuronal networks involved in central pattern generation. Importantly, all of these RSNs showed a restricted spatial extent along the spinal cord and likely conform to the spinal cord’s functionally relevant segmental organization. Although the spatial and temporal properties of the dorsal and ventral RSNs were found to be significantly different, these networks showed significant interactions with each other at the segmental level. Together, our data demonstrate that intrinsically highly organized resting-state fluctuations exist in the human spinal cord and are thus a hallmark of the entire central nervous system. PMID:25472845

  8. Intrinsic Feature Pose Measurement for Awake Animal SPECT Imaging

    SciTech Connect

    Goddard Jr, James Samuel; Baba, Justin S; Lee, Seung Joon; Weisenberger, A G; Stolin, A; McKisson, J; Smith, M F

    2009-01-01

    New developments have been made in optical motion tracking for awake animal imaging that measures 3D position and orientation (pose) for a single photon emission computed tomography (SPECT) imaging system. Ongoing SPECT imaging research has been directed towards head motion measurement for brain studies in awake, unrestrained mice. In contrast to previous results using external markers, this work extracts and tracks intrinsic features from multiple camera images and computes relative pose from the tracked features over time. Motion tracking thus far has been limited to measuring extrinsic features such as retro-reflective markers applied to the mouse s head. While this approach has been proven to be accurate, the additional animal handling required to attach the markers is undesirable. A significant improvement in the procedure is achieved by measuring the pose of the head without extrinsic markers using only the external surface appearance. This approach is currently being developed with initial results presented here. The intrinsic features measurement extracts discrete, sparse natural features from 2D images such as eyes, nose, mouth and other visible structures. Stereo correspondence between features for a camera pair is determined for calculation of 3D positions. These features are also tracked over time to provide continuity for surface model fitting. Experimental results from live images are presented.

  9. Shepherding intrinsic localized modes in micro-mechanical arrays

    NASA Astrophysics Data System (ADS)

    Sievers, Albert

    The energy profiles of intrinsic localized modes (ILMs) in periodic physical lattices with nonlinear forces resemble those of localized vibrational modes at defects in a harmonic lattice but, like solitons, they can propagate; however, in contrast with solitons they loose energy as they move through the lattice - the more localized the excitation the faster the energy loss. One of our experimental studies with micro-mechanical arrays involves steady state locking of ILMs, and their interactions with impurities. By measuring the linear response spectra of a driven array containing an ILM both the dynamics of bifurcation transitions and the hopping of vibrational energy have been connected to the transition properties of soft modes. Recently the search for a completely mobile ILM has focused attention on minimizing the resonance interaction that occurs between the localized excitation and small amplitude plane wave modes. Via simulations we demonstrate that when more than one type of nonlinear force is present their Fourier components can often be designed to cancel against each other in the k-space region of the plane wave dispersion curve, removing the resonance. The end result is super-transmission for an ILM in a discrete physical lattice. Such an engineered, intrinsic, low loss channel may prove to be a useful property for other physical systems treated within a tight binding approximation. In collaboration with M. Sato.

  10. Learning and Aging Related Changes in Intrinsic Neuronal Excitability

    PubMed Central

    Oh, M. Matthew; Oliveira, Fernando A.; Disterhoft, John F.

    2010-01-01

    A goal of many laboratories that study aging is to find a key cellular change(s) that can be manipulated and restored to a young-like state, and thus, reverse the age-related cognitive deficits. We have chosen to focus our efforts on the alteration of intrinsic excitability (as reflected by the postburst afterhyperpolarization, AHP) during the learning process in hippocampal pyramidal neurons. We have consistently found that the postburst AHP is significantly reduced in hippocampal pyramidal neurons from young adults that have successfully learned a hippocampus-dependent task. In the context of aging, the baseline intrinsic excitability of hippocampal neurons is decreased and therefore cognitive learning is impaired. In aging animals that are able to learn, neuron changes in excitability similar to those seen in young neurons during learning occur. Our challenge, then, is to understand how and why excitability changes occur in neurons from aging brains and cause age-associated learning impairments. After understanding the changes, we should be able to formulate strategies for reversing them, thus making old neurons function more as they did when they were young. Such a reversal should rescue the age-related cognitive deficits. PMID:20552042

  11. Intrinsic-mediated caspase activation is essential for cardiomyocyte hypertrophy.

    PubMed

    Putinski, Charis; Abdul-Ghani, Mohammad; Stiles, Rebecca; Brunette, Steve; Dick, Sarah A; Fernando, Pasan; Megeney, Lynn A

    2013-10-22

    Cardiomyocyte hypertrophy is the cellular response that mediates pathologic enlargement of the heart. This maladaptation is also characterized by cell behaviors that are typically associated with apoptosis, including cytoskeletal reorganization and disassembly, altered nuclear morphology, and enhanced protein synthesis/translation. Here, we investigated the requirement of apoptotic caspase pathways in mediating cardiomyocyte hypertrophy. Cardiomyocytes treated with hypertrophy agonists displayed rapid and transient activation of the intrinsic-mediated cell death pathway, characterized by elevated levels of caspase 9, followed by caspase 3 protease activity. Disruption of the intrinsic cell death pathway at multiple junctures led to a significant inhibition of cardiomyocyte hypertrophy during agonist stimulation, with a corresponding reduction in the expression of known hypertrophic markers (atrial natriuretic peptide) and transcription factor activity [myocyte enhancer factor-2, nuclear factor kappa B (NF-κB)]. Similarly, in vivo attenuation of caspase activity via adenoviral expression of the biologic effector caspase inhibitor p35 blunted cardiomyocyte hypertrophy in response to agonist stimulation. Treatment of cardiomyocytes with procaspase 3 activating compound 1, a small-molecule activator of caspase 3, resulted in a robust induction of the hypertrophy response in the absence of any agonist stimulation. These results suggest that caspase-dependent signaling is necessary and sufficient to promote cardiomyocyte hypertrophy. These results also confirm that cell death signal pathways behave as active remodeling agents in cardiomyocytes, independent of inducing an apoptosis response.

  12. Intrinsic half-metallicity in fractal carbon nitride honeycomb lattices.

    PubMed

    Wang, Aizhu; Zhao, Mingwen

    2015-09-14

    Fractals are natural phenomena that exhibit a repeating pattern "exactly the same at every scale or nearly the same at different scales". Defect-free molecular fractals were assembled successfully in a recent work [Shang et al., Nature Chem., 2015, 7, 389-393]. Here, we adopted the feature of a repeating pattern in searching two-dimensional (2D) materials with intrinsic half-metallicity and high stability that are desirable for spintronics applications. Using first-principles calculations, we demonstrate that the electronic properties of fractal frameworks of carbon nitrides have stable ferromagnetism accompanied by half-metallicity, which are highly dependent on the fractal structure. The ferromagnetism increases gradually with the increase of fractal order. The Curie temperature of these metal-free systems estimated from Monte Carlo simulations is considerably higher than room temperature. The stable ferromagnetism, intrinsic half-metallicity, and fractal characteristics of spin distribution in the carbon nitride frameworks open an avenue for the design of metal-free magnetic materials with exotic properties.

  13. Intrinsic germanium detector used in borehole sonde for uranium exploration

    USGS Publications Warehouse

    Senftle, F.E.; Moxham, R.M.; Tanner, A.B.; Boynton, G.R.; Philbin, P.W.; Baicker, J.A.

    1976-01-01

    A borehole sonde (~1.7 m long; 7.3 cm diameter) using a 200 mm2 planar intrinsic germanium detector, mounted in a cryostat cooled by removable canisters of frozen propane, has been constructed and tested. The sonde is especially useful in measuring X- and low-energy gamma-ray spectra (40–400 keV). Laboratory tests in an artificial borehole facility indicate its potential for in-situ uranium analyses in boreholes irrespective of the state of equilibrium in the uranium series. Both natural gamma-ray and neutron-activation gamma-ray spectra have been measured with the sonde. Although the neutron-activation technique yields greater sensitivity, improvements being made in the resolution and efficiency of intrinsic germanium detectors suggest that it will soon be possible to use a similar sonde in the passive mode for measurement of uranium in a borehole down to about 0.1% with acceptable accuracy. Using a similar detector and neutron activation, the sonde can be used to measure uranium down to 0.01%.

  14. Elastin-like Polypeptides as Models of Intrinsically Disordered Proteins

    PubMed Central

    Roberts, Stefan; Dzuricky, Michael; Chilkoti, Ashutosh

    2015-01-01

    Elastin-like polypeptides (ELPs) are a class of stimuli-responsive biopolymers inspired by the intrinsically disordered domains of tropoelastin that are composed of repeats of the VPGXG pentapeptide motif, where X is a “guest residue”. They undergo a reversible, thermally triggered lower critical solution temperature (LCST) phase transition, which has been utilized for a variety of applications including protein purification, affinity capture, immunoassays, and drug delivery. ELPs have been extensively studied as protein polymers and as biomaterials, but their relationship to other disordered proteins has heretofore not been established. The biophysical properties of ELPs that lend them their unique material behavior are similar to the properties of many intrinsically disordered proteins (IDP). Their low sequence complexity, phase behavior, and elastic properties make them an interesting “minimal” artificial IDP, and the study of ELPs can hence provide insights into the behavior of other more complex IDPs. Motivated by this emerging realization of the similarities between ELPs and IDPs, this review discusses the biophysical properties of ELPs, their biomedical utility, and their relationship to other disordered polypeptide sequences. PMID:26325592

  15. An intrinsically safe mechanism for physically coupling humans with robots.

    PubMed

    O'Neill, Gerald; Patel, Harshil; Artemiadis, Panagiotis

    2013-06-01

    Robots are increasingly used in tasks that include physical interaction with humans. Examples can be found in the area of rehabilitation robotics, power augmentation robots, as well as assistive and orthotic devices. However, current methods of physically coupling humans with robots fail to provide intrinsic safety, adaptation and efficiency, which limit the application of wearable robotics only to laboratory and controlled environments. In this paper we present the design and verification of a novel mechanism for physically coupling humans and robots. The device is intrinsically safe, since it is based on passive, non-electric features that are not prone to malfunctions. The device is capable of transmitting forces and torques in all directions between the human user and the robot. Moreover, its re-configurable nature allows for easy and consistent adjustment of the decoupling force. The latter makes the mechanism applicable to a wide range of human-robot coupling applications, ranging from low-force rehabilitation-therapy scenarios to high-force augmentation cases.

  16. Type D vacuum solutions: a new intrinsic approach

    NASA Astrophysics Data System (ADS)

    Ferrando, Joan Josep; Sáez, Juan Antonio

    2014-04-01

    We present a new approach to the intrinsic properties of the type D vacuum solutions based on the invariant symmetries that these spacetimes admit. By using tensorial formalism and without explicitly integrating the field equations, we offer a new proof that the upper bound of covariant derivatives of the Riemann tensor required for a Cartan-Karlhede classification is two. Moreover we show that, except for the Ehlers-Kundt's C-metrics, the Riemann derivatives depend on the first order ones, and for the C-metrics they depend on the first order derivatives and on a second order constant invariant. In our analysis the existence of an invariant complex Killing vector plays a central role. It also allows us to easily obtain and to geometrically interpret several known relations. We apply to the vacuum case the intrinsic classification of the type D spacetimes based on the first order differential properties of the 2 + 2 Weyl principal structure, and we show that only six classes are compatible. We define several natural and suitable subclasses and present an operational algorithm to detect them.

  17. Effects of intrinsic and extrinsic motivation on attention and memory.

    PubMed

    Robinson, Lucy J; Stevens, Lucy H; Threapleton, Christopher J D; Vainiute, Jurgita; McAllister-Williams, R Hamish; Gallagher, Peter

    2012-10-01

    It is well recognised that motivational factors can influence neuropsychological performance. The aim of this study was to explore individual differences in intrinsic motivation and reward-seeking and the effect of these on attentional and mnemonic processes, in the presence or absence of financial incentives. Forty participants (18-35years) completed two testing sessions where the Attentional Network Test (ANT) and the Newcastle Spatial Memory Test (NSMT) were administered. After a baseline assessment, participants were re-tested after randomisation to a non-motivated (control) group or to a motivated group, where payment was contingent upon performance. Performance in the motivated group was significantly improved compared to the control group on the NSMT (condition by session; F(1,33)=4.52, p=0.041) and the ANT, with participants increasing performance to cued presentations within the alerting network (F(1,36)=5.48, p=0.025) and being less distracted by incongruent stimuli in the executive control network (F(1,36)=6.74, p=0.014). There were significant negative correlations between the 'Interest/ Enjoyment' Intrinsic Motivation Inventory subscale and both NSMT between-search errors and ANT(alerting). In the motivated group, those who had higher self-reported internal motivation were less susceptible to- or affected by- the external motivation of financial incentive. The effects of motivational factors should not be overlooked when interpreting absolute levels of performance in neuropsychological processes.

  18. Isolating intrinsic noise sources in a stochastic genetic switch

    NASA Astrophysics Data System (ADS)

    Newby, Jay M.

    2012-04-01

    The stochastic mutual repressor model is analysed using perturbation methods. This simple model of a gene circuit consists of two genes and three promotor states. Either of the two protein products can dimerize, forming a repressor molecule that binds to the promotor of the other gene. When the repressor is bound to a promotor, the corresponding gene is not transcribed and no protein is produced. Either one of the promotors can be repressed at any given time or both can be unrepressed, leaving three possible promotor states. This model is analysed in its bistable regime in which the deterministic limit exhibits two stable fixed points and an unstable saddle, and the case of small noise is considered. On small timescales, the stochastic process fluctuates near one of the stable fixed points, and on large timescales, a metastable transition can occur, where fluctuations drive the system past the unstable saddle to the other stable fixed point. To explore how different intrinsic noise sources affect these transitions, fluctuations in protein production and degradation are eliminated, leaving fluctuations in the promotor state as the only source of noise in the system. The process without protein noise is then compared to the process with weak protein noise using perturbation methods and Monte Carlo simulations. It is found that some significant differences in the random process emerge when the intrinsic noise source is removed.

  19. Folding propensity of intrinsically disordered proteins by osmotic stress†

    PubMed Central

    Mansouri, Amanda L.; Grese, Laura N.; Rowe, Erica L.; Pino, James C.; Chennubhotla, S. Chakra; Ramanathan, Arvind; O’Neill, Hugh M.; Berthelier, Valerie

    2017-01-01

    Proteins imparted with intrinsic disorder conduct a range of essential cellular functions. To better understand the folding and hydration properties of intrinsically disordered proteins (IDPs), we used osmotic stress to induce conformational changes in nuclear co-activator binding domain (NCBD) and activator for thyroid hormone and retinoid receptor (ACTR) separate from their mutual binding. Osmotic stress was applied by the addition of small and polymeric osmolytes, where we discovered that water contributions to NCBD folding always exceeded those for ACTR. Both NCBD and ACTR were found to gain α-helical structure with increasing osmotic stress, consistent with their folding upon NCBD/ACTR complex formation. Using small-angle neutron scattering (SANS), we further characterized NCBD structural changes with the osmolyte ethylene glycol. Here a large reduction in overall size initially occurred before substantial secondary structural change. By focusing on folding propensity, and linked hydration changes, we uncover new insights that may be important for how IDP folding contributes to binding. PMID:27752679

  20. Tractography from HARDI using an intrinsic unscented Kalman filter.

    PubMed

    Cheng, Guang; Salehian, Hesamoddin; Forder, John R; Vemuri, Baba C

    2015-01-01

    A novel adaptation of the unscented Kalman filter (UKF) was recently introduced in literature for simultaneous multitensor estimation and fiber tractography from diffusion MRI. This technique has the advantage over other tractography methods in terms of computational efficiency, due to the fact that the UKF simultaneously estimates the diffusion tensors and propagates the most consistent direction to track along. This UKF and its variants reported later in literature however are not intrinsic to the space of diffusion tensors. Lack of this key property can possibly lead to inaccuracies in the multitensor estimation as well as in the tractography. In this paper, we propose a novel intrinsic unscented Kalman filter (IUKF) in the space of diffusion tensors which are symmetric positive definite matrices, that can be used for simultaneous recursive estimation of multitensors and propagation of directional information for use in fiber tractography from diffusion weighted MR data. In addition to being more accurate, IUKF retains all the advantages of UKF mentioned above. We demonstrate the accuracy and effectiveness of the proposed method via experiments publicly available phantom data from the fiber cup-challenge (MICCAI 2009) and diffusion weighted MR scans acquired from human brains and rat spinal cords.

  1. Gamma camera intrinsic uniformity in an unstable power supply environment.

    PubMed

    Ejeh, John E; Adedapo, Kayode S; Akinlade, Bidemi I; Osifo, Bola O A

    2011-01-01

    The main objective of this work was to show that a gamma camera in a developing country could perform efficiently despite electricity outages using intrinsic flood uniformity tests as an index of performance. A total of 143 intrinsic uniformity test results for a new gamma camera in use in an environment with unstable power supply are presented. The integral uniformity for the central field of view (CFOV) was found to be between 3.43% and 1.49% (3.29% for acceptance test) while the integral uniformity for the useful field of view (UFOV) was between 4.51% and 1.9% (5.21% for acceptance test). The differential uniformity for the CFOV was between 1.99% and 1.04% (2.25% for acceptance test) while that of the UFOV was between 2.84% and 1.23% (2.63% for acceptance test). In conclusion, these results show that the uniformity of the gamma camera under this condition is within an acceptable range for both planar and SPET imaging.

  2. Altered striatal intrinsic functional connectivity in pediatric anxiety

    PubMed Central

    Dorfman, Julia; Benson, Brenda; Farber, Madeline; Pine, Daniel; Ernst, Monique

    2016-01-01

    Anxiety disorders are among the most common psychiatric disorders of adolescence. Behavioral and task-based imaging studies implicate altered reward system function, including striatal dysfunction, in adolescent anxiety. However, no study has yet examined alterations of the striatal intrinsic functional connectivity in adolescent anxiety disorders. The current study examines striatal intrinsic functional connectivity (iFC), using six bilateral striatal seeds, among 35 adolescents with anxiety disorders and 36 healthy comparisons. Anxiety is associated with abnormally low iFC within the striatum (e.g., between nucleus accumbens and caudate nucleus), and between the striatum and prefrontal regions, including subgenual anterior cingulate cortex, posterior insula and supplementary motor area. The current findings extend prior behavioral and task-based imaging research, and provide novel data implicating decreased striatal iFC in adolescent anxiety. Alterations of striatal neurocircuitry identified in this study may contribute to the perturbations in the processing of motivational, emotional, interoceptive, and motor information seen in pediatric anxiety disorders. This pattern of the striatal iFC perturbations can guide future research on specific mechanisms underlying anxiety. PMID:27004799

  3. The architecture and contraction time of intrinsic foot muscles.

    PubMed

    Tosovic, Danijel; Ghebremedhin, Estifanos; Glen, Christopher; Gorelick, Mark; Mark Brown, J

    2012-12-01

    Although critical for effective human locomotion and posture, little data exists regarding the segmentation, architecture and contraction time of the human intrinsic foot muscles. To address this issue, the Abductor Hallucis (AH), Abductor Digiti Minimi (ADM), Flexor Digitorum Brevis (FDB) and Extensor Digitorum Brevis (EDB) were investigated utilizing a cadaveric dissection and a non-invasive whole muscle mechanomyographic (wMMG) technique. The segmental structure and architecture of formaldehyde-fixed foot specimens were determined in nine cadavers aged 60-80 years. The wMMG technique was used to determine the contraction time (Tc) of individual muscle segments, within each intrinsic foot muscle, in 12 volunteers of both genders aged between 19 and 24 years. While the pattern of segmentation and segmental -architecture (e.g. fibre length) and -Tc of individual muscle segments within the same muscle were similar, they varied between muscles. Also, the average whole muscle Tc of FDB was significantly (p < 0.05) shorter (faster) (Tc = 58 ms) than in all other foot muscles investigated (ADM Tc = 72 ms, EDB Tc = 72 ms and ABH Tc = 69 ms). The results suggest that the architecture and contraction time of the FDB reflect its unique direct contribution, through toe flexion, to postural stability and the rapid development of ground reaction forces during forceful activities such as running and jumping.

  4. Intrinsic Size Parameters for Palmitoylated and Carboxyamidomethylated Peptides

    PubMed Central

    Li, Zhiyu; Dilger, Jonathan M.; Pejaver, Vikas; Smiley, David; Arnold, Randy J.; Mooney, Sean D.; Mukhopadhyay, Suchetana; Radivojac, Predrag; Clemmer, David E.

    2015-01-01

    Cross sections for 61 palmitoylated peptides and 73 cysteine-unmodified peptides are determined and used together with a previously obtained tryptic peptide library to derive a set of intrinsic size parameters (ISPs) for the palmitoyl (Pal) group (1.26 ± 0.04), carboxyamidomethyl (Am) group (0.92 ± 0.04), and the 20 amino acid residues to assess the influence of Pal- and Am-modification on cysteine and other amino acid residues. These values highlight the influence of the intrinsic hydrophobic and hydrophilic nature of these modifications on the overall cross sections. As a part of this analysis, we find that ISPs derived from a database of a modifier on one amino acid residue (CysPal) can be applied on the same modification group on different amino acid residues (SerPal and TyrPal). Using these ISP values, we are able to calculate peptide cross sections to within ± 2% of experimental values for 83% of Pal-modified peptide ions and 63% of Am-modified peptide ions. We propose that modification groups should be treated as individual contribution factors, instead of treating the combination of the particular group and the amino acid residue they are on as a whole when considering their effects on the peptide ion mobility features. PMID:26023288

  5. Plastic-casting intrinsic-surface unique identifier (tag)

    SciTech Connect

    Palm, R.G.; De Volpi, A.

    1995-04-01

    This report describes the development of an authenticated intrinsic-surf ace tagging method for unique- identification of controlled items. Although developed for control of items limited by an arms control treaty, this method has other potential applications to keep track of critical or high-value items. Each tag (unique-identifier) consists of the intrinsic, microscopic surface topography of a small designated area on a controlled item. It is implemented by making a baseline plastic casting of the designated tag area and usually placing a cover (for example, a bar-code label) over this area to protect the surface from environmental alteration. The plastic casting is returned to a laboratory and prepared for high-resolution scanning electron microscope imaging. Several images are digitized and stored for use as a standard for authentication of castings taken during future inspections. Authentication is determined by numerically comparing digital images. Commercially available hardware and software are used for this tag. Tag parameters are optimized, so unique casting images are obtained from original surfaces, and images obtained from attempted duplicate surfaces are detected. This optimization uses the modulation transfer function, a first principle of image analysis, to determine the parameters. Surface duplication experiments confirmed the optimization.

  6. Intrinsic antiferromagnetic/insulating phase at manganite surfaces and interfaces.

    PubMed

    Valencia, S; Peña, L; Konstantinovic, Z; Balcells, Ll; Galceran, R; Schmitz, D; Sandiumenge, F; Casanove, M; Martínez, B

    2014-04-23

    In this work we investigate interfacial effects in bilayer systems integrated by La(2/3)Sr(1/3)MnO(3) (LSMO) thin films and different capping layers by means of surface-sensitive synchrotron radiation techniques and transport measurements. Our data reveal a complex scenario with a capping-dependent variation of the Mn oxidation state by the interface. However, irrespective of the capping material, an antiferromagnetic/insulating phase is also detected at the interface, which is likely to originate from a preferential occupancy of Mn 3d 3z(2)-r(2) e(g) orbitals. This phase, which extends approximately to two unit cells, is also observed in uncapped LSMO reference samples, thus pointing to an intrinsic interfacial phase separation phenomenon, probably promoted by the structural disruption and inversion symmetry breaking at the LSMO free surface/interface. These experimental observations strongly suggest that the structural disruption, with its intrinsic inversion symmetry breaking at the LSMO interfaces, plays a major role in the observed depressed magnetotransport properties in manganite-based magnetic tunneling junctions and explains the origin of the so-called dead layer.

  7. Intrinsic connectivity of neural networks in the awake rabbit.

    PubMed

    Schroeder, Matthew P; Weiss, Craig; Procissi, Daniel; Disterhoft, John F; Wang, Lei

    2016-04-01

    The way in which the brain is functionally connected into different networks has emerged as an important research topic in order to understand normal neural processing and signaling. Since some experimental manipulations are difficult or unethical to perform in humans, animal models are better suited to investigate this topic. Rabbits are a species that can undergo MRI scanning in an awake and conscious state with minimal preparation and habituation. In this study, we characterized the intrinsic functional networks of the resting New Zealand White rabbit brain using BOLD fMRI data. Group independent component analysis revealed seven networks similar to those previously found in humans, non-human primates and/or rodents including the hippocampus, default mode, cerebellum, thalamus, and visual, somatosensory, and parietal cortices. For the first time, the intrinsic functional networks of the resting rabbit brain have been elucidated demonstrating the rabbit's applicability as a translational animal model. Without the confounding effects of anesthetics or sedatives, future experiments may employ rabbits to understand changes in neural connectivity and brain functioning as a result of experimental manipulation (e.g., temporary or permanent network disruption, learning-related changes, and drug administration).

  8. Reconfiguration of Intrinsic Functional Coupling Patterns Following Circumscribed Network Lesions.

    PubMed

    Eldaief, Mark C; McMains, Stephanie; Hutchison, R Matthew; Halko, Mark A; Pascual-Leone, Alvaro

    2016-05-25

    Communication between cortical regions is necessary for optimal cognitive processing. Functional relationships between cortical regions can be inferred through measurements of temporal synchrony in spontaneous activity patterns. These relationships can be further elaborated by surveying effects of cortical lesions upon inter-regional connectivity. Lesions to cortical hubs and heteromodal association regions are expected to induce distributed connectivity changes and higher-order cognitive deficits, yet their functional consequences remain relatively unexplored. Here, we used resting-state fMRI to investigate intrinsic functional connectivity (FC) and graph theoretical metrics in 12 patients with circumscribed lesions of the medial prefrontal cortex (mPFC) portion of the Default Network (DN), and compared these metrics with those observed in healthy matched comparison participants and a sample of 1139 healthy individuals. Despite significant mPFC destruction, patients did not demonstrate weakened intrinsic FC among undamaged DN nodes. Instead, network-specific changes were manifested as weaker negative correlations between the DN and attentional and somatomotor networks. These findings conflict with the DN being a homogenous system functionally anchored at mPFC. Rather, they implicate a role for mPFC in mediating cross-network functional interactions. More broadly, our data suggest that lesions to association cortical hubs might induce clinical deficits by disrupting communication between interacting large-scale systems.

  9. Intrinsic properties of limb bud cells can be differentially reset.

    PubMed

    Saiz-Lopez, Patricia; Chinnaiya, Kavitha; Towers, Matthew; Ros, Maria A

    2017-02-01

    An intrinsic timing mechanism specifies the positional values of the zeugopod (i.e. radius/ulna) and then autopod (i.e. wrist/digits) segments during limb development. Here, we have addressed whether this timing mechanism ensures that patterning events occur only once by grafting GFP-expressing autopod progenitor cells to the earlier host signalling environment of zeugopod progenitor cells. We show by detecting Hoxa13 expression that early and late autopod progenitors fated for the wrist and phalanges, respectively, both contribute to the entire host autopod, indicating that the autopod positional value is irreversibly determined. We provide evidence that Hoxa13 provides an autopod-specific positional value that correctly allocates cells into the autopod, most likely through the control of cell-surface properties as shown by cell-cell sorting analyses. However, we demonstrate that only the earlier autopod cells can adopt the host proliferation rate to permit normal morphogenesis. Therefore, our findings reveal that the ability of embryonic cells to differentially reset their intrinsic behaviours confers robustness to limb morphogenesis. We speculate that this plasticity could be maintained beyond embryogenesis in limbs with regenerative capacity.

  10. Impact of polarization on the intrinsic cosmic microwave background bispectrum

    NASA Astrophysics Data System (ADS)

    Pettinari, Guido W.; Fidler, Christian; Crittenden, Robert; Koyama, Kazuya; Lewis, Antony; Wands, David

    2014-11-01

    We compute the cosmic microwave background (CMB) bispectrum induced by the evolution of the primordial density perturbations, including for the first time both temperature and polarization using a second-order Boltzmann code. We show that including polarization can increase the signal-to-noise by a factor 4 with respect to temperature alone. We find the expected signal-to-noise for this intrinsic bispectrum of S /N =3.8 ,2.9 ,1.6 and 0.5 for an ideal experiment with an angular resolution of ℓmax=3000 , the proposed CMB surveys PRISM and COrE, and Planck's polarized data, respectively; the bulk of this signal comes from E -mode polarization and from squeezed configurations. We discuss how CMB lensing is expected to reduce these estimates as it suppresses the bispectrum for squeezed configurations and contributes to the noise in the estimator. We find that the presence of the intrinsic bispectrum will bias a measurement of primordial non-Gaussianity of local type by fNLintr=0.66 for an ideal experiment with ℓmax=3000 . Finally, we verify the robustness of our results by recovering the analytic approximation for the squeezed-limit bispectrum in the general polarized case.

  11. Intrinsic and extrinsic influences on children's acceptance of new foods.

    PubMed

    Blissett, Jackie; Fogel, Anna

    2013-09-10

    The foods that tend to be rejected by children include those which may have greatest importance for later health. This paper reviews some of the intrinsic and extrinsic influences on preschool children's eating behavior, with particular reference to their acceptance of new foods into their diet. Factors conceptualized as intrinsic to the child in this review include sensory processing, taste perception, neophobia, and temperament. The important extrinsic determinants of children's food acceptance which are reviewed include parental and peer modeling, the family food environment, infant feeding practices including breastfeeding and age at weaning, concurrent feeding practices including restriction, pressure to eat, prompting and reward, and the taste & energy content of foods. Children's willingness to accept new foods is influenced by a wide range of factors that likely have individual and also interactive effects on children's willingness to taste, and then continue to eat, new foods. The literature lacks longitudinal and experimental studies, which will be particularly important in determining interventions most likely to be effective in facilitating children's acceptance of healthy foods.

  12. Changing the Environment Based on Empowerment as Intrinsic Motivation

    NASA Astrophysics Data System (ADS)

    Salge, Christoph; Glackin, Cornelius; Polani, Daniel

    2014-05-01

    One aspect of intelligence is the ability to restructure your own environment so that the world you live in becomes more beneficial to you. In this paper we investigate how the information-theoretic measure of agent empowerment can provide a task-independent, intrinsic motivation to restructure the world. We show how changes in embodiment and in the environment change the resulting behaviour of the agent and the artefacts left in the world. For this purpose, we introduce an approximation of the established empowerment formalism based on sparse sampling, which is simpler and significantly faster to compute for deterministic dynamics. Sparse sampling also introduces a degree of randomness into the decision making process, which turns out to beneficial for some cases. We then utilize the measure to generate agent behaviour for different agent embodiments in a Minecraft-inspired three dimensional block world. The paradigmatic results demonstrate that empowerment can be used as a suitable generic intrinsic motivation to not only generate actions in given static environments, as shown in the past, but also to modify existing environmental conditions. In doing so, the emerging strategies to modify an agent's environment turn out to be meaningful to the specific agent capabilities, i.e., de facto to its embodiment.

  13. Redefining Field Capacity: Intrinsic Criteria for Soil Internal Drainage Dynamics

    NASA Astrophysics Data System (ADS)

    Assouline, S.; Or, D.

    2014-12-01

    Across many soil types and conditions, soil internal drainage exhibits predictable dynamics that converge to a stable hydration state termed "field capacity" (FC). Notwithstanding the usefulness of this natural state as a hydrologic benchmark for modeling and for estimation of plant available soil water, FC had been fraught with ambiguities and inconsistencies since its inception. We propose using a soil intrinsic characteristic length (derived from drainable soil pore size distribution) to mark conditions for loss of hydraulic continuity linked with attainment of FC. This static criterion for FC was extended to define a general and self-consistent dynamic criterion for internal drainage dynamics. A systematic evaluation of the proposed FC definitions using a numerical model and experimental data reveals remarkable consistency and predictability across a wide range of soil types. The new intrinsic metrics provide the necessary definitiveness for this useful concept relevant to a broad range of agronomic, hydrologic, ecological and climatic applications. The consistency of FC hydration state must have played an important role in shaping life in soil not only in terms of plant available water, but also in the aquatic habitats it defines for soil biota.

  14. Redefining field capacity: intrinsic criteria for soil internal drainage dynamics

    NASA Astrophysics Data System (ADS)

    Assouline, Shmuel; Or, Dani

    2015-04-01

    Across many soil types and conditions, soil internal drainage exhibits predictable dynamics that converge to a stable hydration state termed "field capacity" (FC). Notwithstanding the usefulness of this natural state as a hydrologic benchmark for modeling and for estimation of plant available soil water, FC had been fraught with ambiguities and inconsistencies since its inception. We propose using a soil intrinsic characteristic length (derived from drainable soil pore size distribution) to mark conditions for loss of hydraulic continuity linked with attainment of FC. This static criterion for FC was extended to define a general and self-consistent dynamic criterion for internal drainage dynamics. A systematic evaluation of the proposed FC definitions using a numerical model and experimental data reveals remarkable consistency and predictability across a wide range of soil types. The new intrinsic metrics provide the necessary definitiveness for this useful concept relevant to a broad range of agronomic, hydrologic, ecological and climatic applications. The consistency of FC hydration state must have played an important role in shaping life in soil not only in terms of plant available water, but also in the aquatic habitats it defines for soil biota.

  15. Towards the Better: Intrinsic Property Amelioration in Bulk Metallic Glasses

    PubMed Central

    Sarac, Baran; Zhang, Long; Kosiba, Konrad; Pauly, Simon; Stoica, Mihai; Eckert, Jürgen

    2016-01-01

    Tailoring the intrinsic length-scale effects in bulk metallic glasses (BMGs) via post-heat treatment necessitates a systematic analyzing strategy. Although various achievements were made in the past years to structurally enhance the properties of different BMG alloys, the influence of short-term sub-glass transition annealing on the relaxation kinetics is still not fully covered. Here, we aim for unraveling the connection between the physical, (thermo)mechanical and structural changes as a function of selected pre-annealing temperatures and time scales with an in-house developed Cu46Zr44Al8Hf2 based BMG alloy. The controlled formation of nanocrystals below 50 nm with homogenous distribution inside the matrix phase via thermal treatment increase the material’s resistance to strain softening by almost an order of magnitude. The present work determines the design aspects of metallic glasses with enhanced mechanical properties via nanostructural modifications, while postulating a counter-argument to the intrinsic property degradation accounted for long-term annealing. PMID:27273477

  16. Ultrasonic resonant piezoelectric actuator with intrinsic torque measurement.

    PubMed

    Pott, Peter P; Matich, Sebastian; Schlaak, Helmut F

    2012-11-01

    Piezoelectric ultrasonic actuators are widely used in small-scale actuation systems, in which a closed-loop position control is usually utilized. To save an additional torque sensor, the intrinsic measurement capabilities of the piezoelectric material can be employed. To prove feasibility, a motor setup with clearly separated actuation for the friction and driving forces is chosen. The motor concept is based on resonant ultrasonic vibrations. To assess the effects of the direct piezoelectric effect, a capacitance bridge-type circuit has been selected. Signal processing is done by a measurement card with an integrated field-programmable gate array. The motor is used to drive a winch, and different torques are applied by means of weights to be lifted. Assessing the bridge voltage, a good proportionality to the applied torque of 1.47 mV/mN·m is shown. A hysteresis of 1% has been determined. The chosen motor concept is useful for intrinsic torque measurement. However, it provides drawbacks in terms of limited mechanical performance, wear, and thermal losses because of the soft piezoelectric material. Future work will comprise the application of the method to commercially available piezoelectric actuators as well as the implementation of the measurement circuit in an embedded system.

  17. Cooperative motion of intrinsic and actuated semiflexible swimmers

    NASA Astrophysics Data System (ADS)

    Llopis, I.; Pagonabarraga, I.; Cosentino Lagomarsino, M.; Lowe, C. P.

    2013-03-01

    We examine the phenomenon of hydrodynamic-induced cooperativity for pairs of flagellated micro-organism swimmers, of which spermatozoa cells are an example. We consider semiflexible swimmers, where inextensible filaments are driven by an internal intrinsic force and torque-free mechanism (intrinsic swimmers). The velocity gain for swimming cooperatively, which depends on both the geometry and the driving, develops as a result of the near-field coupling of bending and hydrodynamic stresses. We identify the regimes where hydrodynamic cooperativity is advantageous and quantify the change in efficiency. When the filaments' axes are parallel, hydrodynamic interaction induces a directional instability that causes semiflexible swimmers that profit from swimming together to move apart from each other. Biologically, this implies that flagella need to select different synchronized collective states and to compensate for directional instabilities (e.g., by binding) in order to profit from swimming together. By analyzing the cooperative motion of pairs of externally actuated filaments, we assess the impact that stress distribution along the filaments has on their collective displacements.

  18. Computational approaches for inferring the functions of intrinsically disordered proteins

    PubMed Central

    Varadi, Mihaly; Vranken, Wim; Guharoy, Mainak; Tompa, Peter

    2015-01-01

    Intrinsically disordered proteins (IDPs) are ubiquitously involved in cellular processes and often implicated in human pathological conditions. The critical biological roles of these proteins, despite not adopting a well-defined fold, encouraged structural biologists to revisit their views on the protein structure-function paradigm. Unfortunately, investigating the characteristics and describing the structural behavior of IDPs is far from trivial, and inferring the function(s) of a disordered protein region remains a major challenge. Computational methods have proven particularly relevant for studying IDPs: on the sequence level their dependence on distinct characteristics determined by the local amino acid context makes sequence-based prediction algorithms viable and reliable tools for large scale analyses, while on the structure level the in silico integration of fundamentally different experimental data types is essential to describe the behavior of a flexible protein chain. Here, we offer an overview of the latest developments and computational techniques that aim to uncover how protein function is connected to intrinsic disorder. PMID:26301226

  19. The histone acetyltransferase p300 promotes intrinsic axonal regeneration.

    PubMed

    Gaub, Perrine; Joshi, Yashashree; Wuttke, Anja; Naumann, Ulrike; Schnichels, Sven; Heiduschka, Peter; Di Giovanni, Simone

    2011-07-01

    Axonal regeneration and related functional recovery following axonal injury in the adult central nervous system are extremely limited, due to a lack of neuronal intrinsic competence and the presence of extrinsic inhibitory signals. As opposed to what occurs during nervous system development, a weak proregenerative gene expression programme contributes to the limited intrinsic capacity of adult injured central nervous system axons to regenerate. Here we show, in an optic nerve crush model of axonal injury, that adenoviral (cytomegalovirus promoter) overexpression of the acetyltransferase p300, which is regulated during retinal ganglion cell maturation and repressed in the adult, can promote axonal regeneration of the optic nerve beyond 0.5 mm. p300 acetylates histone H3 and the proregenerative transcription factors p53 and CCAAT-enhancer binding proteins in retinal ganglia cells. In addition, it directly occupies and acetylates the promoters of the growth-associated protein-43, coronin 1 b and Sprr1a and drives the gene expression programme of several regeneration-associated genes. On the contrary, overall increase in cellular acetylation using the histone deacetylase inhibitor trichostatin A, enhances retinal ganglion cell survival but not axonal regeneration after optic nerve crush. Therefore, p300 targets both the epigenome and transcription to unlock a post-injury silent gene expression programme that would support axonal regeneration.

  20. The Universal Unification Model of AGN

    NASA Astrophysics Data System (ADS)

    Vilkoviskij, E. Y.

    1998-12-01

    It is shown, that the model calculations of the absorption line profiles are possible in the framework of a common model both for BAL QSOs and the Seyfert galaxies with BAL. We suppose that in both cases the BAL-clouds move in the space between two conic surface, starting in the internal surface of the absorbing torus. We argue that the common nature of the intrinsic line absorption in these objects can be explained in an universal unified AGN model, where BAL AGNs are objects intermediate between AGN1 and AGN2

  1. Intrinsic Efficiency Calibration Considering Geometric Factors in Gamma-ray Computed Tomography for Radioactive Waste Assay

    SciTech Connect

    Liu, Zhe; Zhang, Li

    2015-07-01

    In radioactive waste assay with gamma-ray computed tomography, calibration for intrinsic efficiency of the system is important to the reconstruction of radioactivity distribution. Due to the geometric characteristics of the system, the non-uniformity of intrinsic efficiency for gamma-rays with different incident positions and directions are often un-negligible. Intrinsic efficiency curves versus geometric parameters of incident gamma-ray are obtained by Monte-Carlo simulation, and two intrinsic efficiency models are suggested to characterize the intrinsic efficiency determined by relative source-detector position and system geometry in the system matrix. Monte-Carlo simulation is performed to compare the different intrinsic efficiency models. Better reconstruction results of radioactivity distribution are achieved by both suggested models than by the uniform intrinsic efficiency model. And compared to model based on detector position, model based on point response increases reconstruction accuracy as well as complexity and time of calculation. (authors)

  2. Interdiffusion and Intrinsic Diffusion in the Mg-Al System

    SciTech Connect

    Brennan, Sarah; Bermudez, Katrina; Sohn, Yong Ho; Kulkarni, Nagraj S

    2012-01-01

    Solid-to-solid diffusion couples were assembled and annealed to examine the diffusion between pure Mg (99.96%) and Al (99.999%). Diffusion anneals were carried out at 300 , 350 , and 400 C for 720, 360, and 240 hours, respectively. Optical and scanning electron microscopes were utilized to identify the formation of the intermetallic phases, -Al12Mg17 and -Al3Mg2 and absence of the -phase in the diffusion couples. Thicknesses of the -Al12Mg17 and -Al3Mg2 phases were measured and the parabolic growth constants were calculated to determine the activation energies for the growth, 165 and 86 KJ/mole, respectively. Concentration profiles were determined with electron microprobe analysis using pure elemental standards. Composition-dependent interdiffusion coefficients in Mg-solid solution, -Al12Mg17 and - Al3Mg2 and Al-solid solutions were calculated based on the Boltzmann-Matano analysis. Average effective interdiffusion coefficients for each phase were also calculated, and the magnitude was the highest for the -Al3Mg2 phase, followed by -Al12Mg17, Al-solid solution and Mg-solid solution. Intrinsic diffusion coefficients based on Huemann s analysis (e.g., marker plane) were determined for the ~38 at.% Mg in the -Al3Mg2 phase. Activation energies and the pre-exponential factors for the inter- and intrinsic diffusion coefficients were calculated for the temperature range examined. The -Al3Mg2 phase was found to have the lowest activation energies for growth and interdiffusion among all four phases studied. At the marker location in the -Al3Mg2 phase, the intrinsic diffusion of Al was found to be faster than that of Mg. Extrapolations of the impurity diffusion coefficients in the terminal solid solutions were made and compared to the available self- and impurity diffusion data from literature. Thermodynamic factor, tracer diffusion coefficients and atomic mobilities at the marker plane composition were approximated using available literature values of Mg activity in the -Al

  3. STELLAR LOCI. I. METALLICITY DEPENDENCE AND INTRINSIC WIDTHS

    SciTech Connect

    Yuan, Haibo; Liu, Xiaowei; Xiang, Maosheng; Huang, Yang; Chen, Bingqiu E-mail: x.liu@pku.edu.cn

    2015-02-01

    Stellar loci are widely used for selection of interesting outliers, reddening determinations, and calibrations. However, until now, the dependence of stellar loci on metallicity has not been fully explored, and their intrinsic widths are unclear. In this paper, by combining the spectroscopic and recalibrated imaging data of the Sloan Digital Sky Survey (SDSS) Stripe 82, we have built a large, clean sample of dwarf stars with accurate colors and well-determined metallicities to investigate the metallicity dependence and intrinsic widths of the SDSS stellar loci. Typically, 1 dex decrease in metallicity causes 0.20 and 0.02 mag decrease in colors u – g and g – r and 0.02 and 0.02 mag increase in colors r – i and i – z, respectively. The variations are larger for metal-rich stars than for metal-poor ones, and larger for F/G/K stars than for A/M ones. Using the sample, we have performed two-dimensional polynomial fitting to the u – g, g – r, r – i, and i – z colors as a function of color g – i and metallicity [Fe/H]. The residuals, at the level of 0.029, 0.008, 0.008, and 0.011 mag for the u – g, g – r, r – i, and i – z colors, respectively, can be fully accounted for by the photometric errors and metallicity uncertainties, suggesting that the intrinsic widths of the loci are at maximum a few millimagnitudes. The residual distributions are asymmetric, revealing that a significant fraction of stars are binaries. In a companion paper, we will present an unbiased estimate of the binary fraction for field stars. Other potential applications of the metallicity-dependent stellar loci are briefly discussed.

  4. Brain Mechanical Property Measurement Using MRE with Intrinsic Activation

    PubMed Central

    Pattison, Adam J.; McGarry, Matthew D.; Perreard, Irina M.; Swienckowski, Jessica G.; Eskey, Clifford J.; Lollis, S. Scott; Paulsen, Keith D.

    2013-01-01

    Problem Addressed Many pathologies alter the mechanical properties of tissue. Magnetic resonance elastography (MRE) has been developed to noninvasively characterize these quantities in vivo. Typically, small vibrations are induced in the tissue of interest with an external mechanical actuator. The resulting displacements are measured with phase contrast sequences and are then used to estimate the underlying mechanical property distribution. Several MRE studies have quantified brain tissue properties. However, the cranium and meninges, especially the dura, are very effective at damping externally applied vibrations from penetrating deeply into the brain. Here, we report a method, termed ‘intrinsic activation’, that eliminates the requirement for external vibrations by measuring the motion generated by natural blood vessel pulsation. Methodology A retrospectively gated phase contrast MR angiography sequence was used to record the tissue velocity at eight phases of the cardiac cycle. The velocities were numerically integrated via the Fourier transform to produce the harmonic displacements at each position within the brain. The displacements were then reconstructed into images of the shear modulus based on both linear elastic and poroelastic models. Results, Significance and Potential Impact The mechanical properties produced fall within the range of brain tissue estimates reported in the literature and, equally important, the technique yielded highly reproducible results. The mean shear modulus was 8.1 kPa for linear elastic reconstructions and 2.4 kPa for poroelastic reconstructions where fluid pressure carries a portion of the stress. Gross structures of the brain were visualized, particularly in the poroelastic reconstructions. Intra-subject variability was significantly less than the inter-subject variability in a study of 6 asymptomatic individuals. Further, larger changes in mechanical properties were observed in individuals when examined over time than when

  5. Evaluating Assessment Using N-Dimensional Filtering.

    ERIC Educational Resources Information Center

    Dron, Jon; Boyne, Chris; Mitchell, Richard

    This paper describes the use of the CoFIND (Collaborative Filter in N Dimensions) system to evaluate two assessment styles. CoFIND is a resource database that organizes itself around its users' needs. Learners enter resources, categorize, then rate them using "qualities," aspects of resources which learners find worthwhile, the n…

  6. Properties of n-dimensional triangulations

    NASA Technical Reports Server (NTRS)

    Lawson, Charles L.

    1986-01-01

    This paper establishes a number of mathematical results relevant to the problem of constructing a triangulation, i.e., a simplical tessellation of the convex hull of an arbitrary finite set of points in n-space. The principal results of the present paper are: (1) a set of n + 2 points in n-space may be triangulated in at most 2 different ways; (2) the 'sphere test' defined in this paper selects a preferred one of these two triangulations; (3) a set of parameters is defined that permits the characterization and enumeration of all sets on n + 2 points in n-space that are significantly different from the point of view of their possible triangulations; and (4) the local sphere test induces a global sphere test property for a triangulation.

  7. Boston University: College and University Systems Environment.

    ERIC Educational Resources Information Center

    CAUSE/EFFECT, 1981

    1981-01-01

    Two major Boston University computer installations--the Academic Computing Center and the office of University Information Systems--are described. Policies and priorities for information systems within the university are established by a committee and proposals for the development of new systems are approved through this committee. (MLW)

  8. A diverse intrinsic antibiotic resistome from a cave bacterium

    PubMed Central

    Pawlowski, Andrew C.; Wang, Wenliang; Koteva, Kalinka; Barton, Hazel A.; McArthur, Andrew G.; Wright, Gerard D.

    2016-01-01

    Antibiotic resistance is ancient and widespread in environmental bacteria. These are therefore reservoirs of resistance elements and reflective of the natural history of antibiotics and resistance. In a previous study, we discovered that multi-drug resistance is common in bacteria isolated from Lechuguilla Cave, an underground ecosystem that has been isolated from the surface for over 4 Myr. Here we use whole-genome sequencing, functional genomics and biochemical assays to reveal the intrinsic resistome of Paenibacillus sp. LC231, a cave bacterial isolate that is resistant to most clinically used antibiotics. We systematically link resistance phenotype to genotype and in doing so, identify 18 chromosomal resistance elements, including five determinants without characterized homologues and three mechanisms not previously shown to be involved in antibiotic resistance. A resistome comparison across related surface Paenibacillus affirms the conservation of resistance over millions of years and establishes the longevity of these genes in this genus. PMID:27929110

  9. Intrinsic Fluctuations and Driven Response of Insect Swarms

    NASA Astrophysics Data System (ADS)

    Ni, Rui; Puckett, James G.; Dufresne, Eric R.; Ouellette, Nicholas T.

    2015-09-01

    Animals of all sizes form groups, as acting together can convey advantages over acting alone; thus, collective animal behavior has been identified as a promising template for designing engineered systems. However, models and observations have focused predominantly on characterizing the overall group morphology, and often focus on highly ordered groups such as bird flocks. We instead study a disorganized aggregation (an insect mating swarm), and compare its natural fluctuations with the group-level response to an external stimulus. We quantify the swarm's frequency-dependent linear response and its spectrum of intrinsic fluctuations, and show that the ratio of these two quantities has a simple scaling with frequency. Our results provide a new way of comparing models of collective behavior with experimental data.

  10. Fast camera observations of injected and intrinsic dust in TEXTOR

    NASA Astrophysics Data System (ADS)

    Shalpegin, A.; Vignitchouk, L.; Erofeev, I.; Brochard, F.; Litnovsky, A.; Bozhenkov, S.; Bykov, I.; den Harder, N.; Sergienko, G.

    2015-12-01

    Stereoscopic fast camera observations of pre-characterized carbon and tungsten dust injection in TEXTOR are reported, along with the modelling of tungsten particle trajectories with MIGRAINe. Particle tracking analysis of the video data showed significant differences in dust dynamics: while carbon flakes were prone to agglomeration and explosive destruction, spherical tungsten particles followed quasi-inertial trajectories. Although this inertial nature prevented any validation of the force models used in MIGRAINe, comparisons between the experimental and simulated lifetimes provide a direct evidence of dust temperature overestimation in dust dynamics codes. Furthermore, wide-view observations of the TEXTOR interior revealed the main production mechanism of intrinsic carbon dust, as well as the location of probable dust remobilization sites.

  11. Regional and seasonal limitations for Mars intrinsic ecopoiesis.

    PubMed

    Badescu, Viorel

    2005-04-01

    Mars ecopoiesis is a human controlled process consisting in changes needed for anaerobic life to be established on planet surface. The daily minimum temperature on present day Mars is well below the water freezing point, due to the low thermal inertia of the surface. A simple time-dependent model to evaluate the ground temperature is developed here. It takes into account the incident solar radiation, the greenhouse effect and surface thermal inertia. The model is applied to two modified Martian atmospheres. Increasing surface thermal inertia seems to be necessary for Mars intrinsic ecopoiesis. This can be done either by removing the regolith layer covering the bedrock or by regolith compression. The Northern hemisphere of the terraformed Mars appears to be more hospitable than the Southern hemisphere, because the amplitude of the daily temperature excursion there is lower and the freezing temperature appears at higher latitudes. A regional (and seasonal) terraforming of Mars is suggested.

  12. Phononic Frequency Comb via Intrinsic Three-Wave Mixing.

    PubMed

    Ganesan, Adarsh; Do, Cuong; Seshia, Ashwin

    2017-01-20

    Optical frequency combs have resulted in significant advances in optical frequency metrology and found wide applications in precise physical measurements and molecular fingerprinting. A direct analogue of frequency combs in the phononic or acoustic domain has not been reported to date. In this Letter, we report the first clear experimental evidence for a phononic frequency comb. We show that the phononic frequency comb is generated through the intrinsic coupling of a driven phonon mode with an autoparametrically excited subharmonic mode. The experiments depict the comb generation process evidenced by a spectral response consisting of equally spaced discrete and phase coherent comb lines. Through systematic experiments at different drive frequencies and amplitudes, we portray the well-connected process of phononic frequency comb formation and define the attributes to control the features associated with comb formation in such a system. In addition to the demonstration of frequency comb, the interplay between the nonlinear resonances and the well-known Duffing phenomenon is also observed.

  13. Controlled generation of intrinsic localized modes in microelectromechanical cantilever arrays

    NASA Astrophysics Data System (ADS)

    Chen, Qingfei; Lai, Ying-Cheng; Dietz, David

    2010-12-01

    We propose a scheme to induce intrinsic localized modes (ILMs) at an arbitrary site in microelectromechanical cantilever arrays. The idea is to locate the particular cantilever beam in the array that one wishes to drive to an oscillating state with significantly higher amplitude than the average and then apply small adjustments to the electrical signal that drives the whole array system. Our scheme is thus a global closed-loop control strategy. We argue that the dynamical mechanism on which our global driving scheme relies is spatiotemporal chaos and we develop a detailed analysis based on the standard averaging method in nonlinear dynamics to understand the working of our control scheme. We also develop a Markov model to characterize the transient time required for inducing ILMs.

  14. Alloy design for intrinsically ductile refractory high-entropy alloys

    NASA Astrophysics Data System (ADS)

    Sheikh, Saad; Shafeie, Samrand; Hu, Qiang; Ahlström, Johan; Persson, Christer; Veselý, Jaroslav; Zýka, Jiří; Klement, Uta; Guo, Sheng

    2016-10-01

    Refractory high-entropy alloys (RHEAs), comprising group IV (Ti, Zr, Hf), V (V, Nb, Ta), and VI (Cr, Mo, W) refractory elements, can be potentially new generation high-temperature materials. However, most existing RHEAs lack room-temperature ductility, similar to conventional refractory metals and alloys. Here, we propose an alloy design strategy to intrinsically ductilize RHEAs based on the electron theory and more specifically to decrease the number of valence electrons through controlled alloying. A new ductile RHEA, Hf0.5Nb0.5Ta0.5Ti1.5Zr, was developed as a proof of concept, with a fracture stress of close to 1 GPa and an elongation of near 20%. The findings here will shed light on the development of ductile RHEAs for ultrahigh-temperature applications in aerospace and power-generation industries.

  15. Intrinsic Axonal Growth and the Drive for Regeneration

    PubMed Central

    O'Donovan, Kevin J.

    2016-01-01

    Following damage to the adult nervous system in conditions like stroke, spinal cord injury, or traumatic brain injury, many neurons die and most of the remaining spared neurons fail to regenerate. Injured neurons fail to regrow both because of the inhibitory milieu in which they reside as well as a loss of the intrinsic growth capacity of the neurons. If we are to develop effective therapeutic interventions that promote functional recovery for the devastating injuries described above, we must not only better understand the molecular mechanisms of developmental axonal growth in hopes of re-activating these pathways in the adult, but at the same time be aware that re-activation of adult axonal growth may proceed via distinct mechanisms. With this knowledge in hand, promoting adult regeneration of central nervous system neurons can become a more tractable and realistic therapeutic endeavor. PMID:27833527

  16. Edge State and Intrinsic Hole Doping in Bilayer Phosphorene

    NASA Astrophysics Data System (ADS)

    Osada, Toshihito

    2015-01-01

    Using a simple LCAO model by Harrison, we have qualitatively studied the edge state of bilayer phosphorene, which is a unit structure of the layered crystal of black phosphorus. This model successfully reproduces the isolated edge state in the bulk gap in monolayer phosphorene. In bilayer phosphorene, however, it shows that edge states are almost buried in the valence band and there is no isolated midgap edge state at the zigzag edge. Since the buried edge state works as acceptor, holes are doped from the edge state into the bulk. This gives a possible explanation for p-type conduction in undoped black phosphorus. Under the vertical electric field, the intrinsic hole doping is reduced because a part of edge states move into the gap. These features of bilayer phosphorene might be better suited for device application.

  17. An intrinsically compliant robotic orthosis for treadmill training.

    PubMed

    Hussain, Shahid; Xie, Sheng Quan; Jamwal, Prashant K; Parsons, John

    2012-12-01

    A new intrinsically compliant robotic orthosis powered by pneumatic muscle actuators (PMA) was developed for treadmill training of neurologically impaired subjects. The robotic orthosis has hip and knee sagittal plane rotations actuated by antagonistic configuration of PMA. The orthosis has passive mechanisms to allow vertical and lateral translations of the trunk and a passive hip abduction/adduction joint. A foot lifter having a passive spring mechanism was used to ensure sufficient foot clearance during swing phase. A trajectory tracking controller was implemented to evaluate the performance of the robotic orthosis on a healthy subject. The results show that the robotic orthosis is able to perform the treadmill training task by providing sufficient torques to achieve physiological gait patterns and a realistic stepping experience. The orthosis is a new addition to the rapidly advancing field of robotic orthoses for treadmill training.

  18. Intrinsic phonon properties of double-walled carbon nanotubes

    NASA Astrophysics Data System (ADS)

    Tran, H. N.; Levshov, D. I.; Nguyen, V. C.; Paillet, M.; Arenal, R.; Than, X. T.; Zahab, A. A.; Yuzyuk, Y. I.; Phan, N. M.; Sauvajol, J.-L.; Michel, T.

    2017-03-01

    Double-walled carbon nanotubes (DWNT) are made of two concentric and weakly van der Waals coupled single-walled carbon nanotubes (SWNT). DWNTs are the simplest systems for studying the mechanical and electronic interactions between concentric carbon layers. In this paper we review recent results concerning the intrinsic features of phonons of DWNTs obtained from Raman experiments performed on index-identified DWNTs. The effect of the interlayer distance on the strength of the mechanical and electronic coupling between the layers, and thus on the frequencies of the Raman-active modes, namely the radial breathing-like modes (RBLMs) and G-modes, are evidenced and discussed. Invited talk at 8th International Workshop on Advanced Materials Science and Nanotechnology (IWAMSN2016), 8–12 November 2016, Ha Long City, Vietnam.

  19. An effective model for microscopic intrinsic localized modes.

    SciTech Connect

    Kalosakas, G.; Bishop, A. R.

    2001-01-01

    We present a system of coupled degrees of freedom that can effectively describe the localization of intra-molecular excitations in the charge transfer solid PtCl. These excitations correspond to the Raman active motion of chlorines (symmetric Pt - Cl stretching). By fitting two parameters of the model we obtain an accurate description of the strong red-shifts that appear in the overtone Raman spectra of the isotopically pure material. The resulting intrinsic localized modes extend on length scales of the order of nanometers. With the same set of parameters the model can reproduce the specific structure of the Raman spectra of naturally abundant PtCl, which contains a random distribution of chloride isotopes.

  20. Intrinsic fluctuations and driven response of insect swarms

    NASA Astrophysics Data System (ADS)

    Ni, Rui; Puckett, James G.; Dufresne, Eric R.; Ouellette, Nicholas T.

    2015-03-01

    Much of our understanding of collective behaviour in social animals comes from passive observations of animal groups. To understand the group dynamics fully, however, we must also characterize the response of animal aggregations to disturbances. Using three-dimensional particle tracking, we study both the intrinsic fluctuations of laboratory swarms of the non-biting midge Chironomus riparius and the response of the swarms to controlled external perturbations: the amplitude-modulated sound of male midge wingbeats. Although these perturbations have an insignificant effect on the behavior of individuals, we find that they can have a strong impact on the collective movement. Intriguingly, the response of the swarm is similar reminiscent to of that of a passive equilibrium system to an external driving force, with microscopic fluctuations underlying combining to produce a macroscopic linear response over a wide range of driving frequencies.