The effect of bronchoscope rotation on tracheal tube orientation at the glottic level in a mannequin.

PubMed

Wong, David T; Yau, Brian; Thapar, Shikha; Adhikary, Sanjib D

2010-10-01

This study examined the effect of external fibreoptic bronchoscope (FOB) rotations on endotracheal tube (ETT) orientations at the glottic level. Using a mannequin, a nasal FOB was inserted for image capture. A second FOB with a preloaded ETT taped to its top was inserted orally into mid-trachea. The FOB with the taped ETT was rotated as a unit in the axial plane to five different external angles (-90°, -45°, 0°, +45°, +90°). At each external rotation, the ETT was advanced into the trachea. The image of the ETT at the glottic level was captured. Endotracheal tube orientation was quantified according to the glottic zone faced by the ETT. The ETT orientations were compared amongst the five external FOB rotations using the Kruskal-Wallis Test, while the ETT orientations at -90°, -45°, +45°, and +90° FOB rotations were compared with 0° rotation using the Mann-Whitney U test. There was a significant difference in the ETT orientations amongst the five FOB rotations (P < 0.001). The ETT orientations at -90°, -45°, +45°, and +90° FOB rotations were different from the 0° rotation (P < 0.001 for all comparisons). A -90° FOB rotation was most effective in turning the ETT tip away from the right laryngeal structures and the interarytenoid tissue. With the ETT loaded on a FOB, rotation of the FOB prior to advancing the ETT is effective in changing the ETT orientation at the glottis. A -90° FOB rotation is most effective in turning the ETT tip away from the right laryngeal structures and interarytenoid tissue.

A comparison of GlideScope(®) videolaryngoscopy and direct laryngoscopy for nasotracheal intubation in children.

PubMed

Kim, Hyun-Jung; Kim, Jin-Tae; Kim, Hee-Soo; Kim, Chong-Sung; Kim, Seong-Deok

2011-04-01

The relative effectiveness of GlideScope(®) videolaryngoscopy (GV) for nasotracheal intubation in pediatric patients is unclear. The purpose of this study is to evaluate the usefulness of GV for nasotracheal intubation compared with direct laryngoscopy (DL) in pediatric patients. Our patient cohort consisted of 80 children <10 years of age who required nasotracheal intubation for elective dental or facial surgery. The patients were randomly allocated to GV (n = 40) or DL (n = 40) group. The time to intubation (TTI), glottic view grade, frequency of Magill forceps use, and degree of difficulty in intubation were evaluated. The median TTI was similar between the groups. The TTI of the former 20 patients was faster in the DL group (53.3 s, interquartile range: 42.0-64.3) than GV group (65.9 s, interquartile range: 56.0-93.9) (P = 0.007), whereas the TTI of the latter 20 patients was comparable between the groups. There were no significant differences in glottic view grade, frequency of Magill forceps use, and degree of difficulty in intubation between the two groups. GV can provide similar intubation performance characteristics compared with DL when used for nasotracheal intubation in pediatric patients. However, experience is needed to be skillful in the GV to acquire comparable TTI with DL. © 2011 Blackwell Publishing Ltd.

Assessment of the storz video Macintosh laryngoscope for use in difficult airways: A human simulator study.

PubMed

Bair, Aaron E; Olmsted, Kalani; Brown, Calvin A; Barker, Tobias; Pallin, Daniel; Walls, Ron M

2010-10-01

Video laryngoscopy has been shown to improve glottic exposure when compared to direct laryngoscopy in operating room studies. However, its utility in the hands of emergency physicians (EPs) remains undefined. A simulated difficult airway was used to determine if intubation by EPs using a video Macintosh system resulted in an improved glottic view, was easier, was faster, or was more successful than conventional direct laryngoscopy. Emergency medicine (EM) residents and attending physicians at two academic institutions performed endotracheal intubation in one normal and two identical difficult airway scenarios. With the difficult scenarios, the participants used video laryngoscopy during the second case. Intubations were performed on a medium-fidelity human simulator. The difficult scenario was created by limiting cervical spine mobility and inducing trismus. The primary outcome was the proportion of direct versus video intubations with a grade I or II Cormack-Lehane glottic view. Ease of intubation (self-reported via 10-cm visual analog scale [VAS]), time to intubation, and success rate were also recorded. Descriptive statistics as well as medians with interquartile ranges (IQRs) are reported where appropriate. The Wilcoxon matched pairs signed-rank test was used for comparison testing of nonparametric data. Participants (n = 39) were residents (59%) and faculty. All had human intubation experience; 51% reported more than 100 prior intubations. On difficult laryngoscopy, a Cormack-Lehane grade I or II view was obtained in 20 (51%) direct laryngoscopies versus 38 (97%) of the video-assisted laryngoscopies (p < 0.01). The median VAS score for difficult airways was 50 mm (IQR = 28–73 mm) for direct versus 18 mm (IQR = 9–50 mm) for video (p < 0.01). The median time to intubation in difficult airways was 25 seconds (IQR = 16–44 seconds) for direct versus 20 seconds (IQR = 12–35 seconds) for video laryngoscopy (p < 0.01). All intubations were successful without need for an invasive airway. In this simulation, video laryngoscopy was associated with improved glottic exposure, was perceived as easier, and was slightly faster than conventional direct laryngoscopy in a simulated difficult airway. Absence of secretions and blood limits the generalizability of our findings; human studies are needed.

Injection laryngoplasty with micronized dermis: a 10-year experience with 381 injections in 344 patients.

PubMed

Tan, Melin; Woo, Peak

2010-12-01

Micronized Dermis (MD) has been used for injection laryngoplasty for correction of glottic insufficiency since 2000. There is controversy whether the material is temporary or permanent. This is a retrospective review of 381 injections in 344 patients. From this review, we hope to better define the role of MD in injection laryngoplasty. Retrospective chart review from a single surgeon (2000-2010) The indications for MD were for both temporary and permanent correction of glottic insufficiency. The diagnoses were: vocal fold paralysis (n = 216), scar (n = 51), atrophy (n = 42), sulcus (n = 22), and others (n = 13). The material has the best effect when placed into the membranous vocal fold just lateral to the vocal ligament. The operative and postoperative complication was 1.05%. Twenty-nine percent of all injections resulted in unwanted absorption. Overinjection was needed and transcervical approach was preferred to prevent implant extrusion with overinjection. The median volume of injected material has increased from 0.8 cc to 1.0 cc over the decade. In 159 patients with long-term follow-up (>1 year), there was a 14% incidence of reinjection. Despite this, the overall need for open procedures in patients with long-term follow-up was 20%. Despite the problems of inconsistency in preparation, slow absorption and need for overinjection, micronized dermis is a safe allograft material that has long-term (>1 year) stability. The material may reduce the need for open surgery. It can be used for both temporary and permanent vocal fold augmentation.

Intubation biomechanics: laryngoscope force and cervical spine motion during intubation with Macintosh and Airtraq laryngoscopes.

PubMed

Hindman, Bradley J; Santoni, Brandon G; Puttlitz, Christian M; From, Robert P; Todd, Michael M

2014-08-01

Laryngoscopy and endotracheal intubation in the presence of cervical spine instability may put patients at risk of cervical cord injury. Nevertheless, the biomechanics of intubation (cervical spine motion as a function of applied force) have not been characterized. This study characterized and compared the relationship between laryngoscope force and cervical spine motion using two laryngoscopes hypothesized to differ in force. Fourteen adults undergoing elective surgery were intubated twice (Macintosh, Airtraq). During each intubation, laryngoscope force, cervical spine motion, and glottic view were recorded. Force and motion were referenced to a preintubation baseline (stage 1) and were characterized at three stages: stage 2 (laryngoscope introduction); stage 3 (best glottic view); and stage 4 (endotracheal tube in trachea). Maximal force and motion occurred at stage 3 and differed between the Macintosh and Airtraq: (1) force: 48.8 ± 15.8 versus 10.4 ± 2.8 N, respectively, P = 0.0001; (2) occiput-C5 extension: 29.5 ± 8.5 versus 19.1 ± 8.7 degrees, respectively, P = 0.0023. Between stages 2 and 3, the motion/force ratio differed between Macintosh and Airtraq: 0.5 ± 0.2 versus 2.0 ± 1.4 degrees/N, respectively; P = 0.0006. The relationship between laryngoscope force and cervical spine motion is: (1) nonlinear and (2) differs between laryngoscopes. Differences between laryngoscopes in motion/force relationships are likely due to: (1) laryngoscope-specific cervical extension needed for intubation, (2) laryngoscope-specific airway displacement/deformation needed for intubation, and (3) cervical spine and airway tissue viscoelastic properties. Cervical spine motion during endotracheal intubation is not directly proportional to force. Low-force laryngoscopes cannot be assumed to result in proportionally low cervical spine motion.

Intubation Biomechanics: Laryngoscope force and cervical spine motion during intubation with Macintosh and Airtraq laryngoscopes

PubMed Central

Hindman, Bradley J.; Santoni, Brandon G.; Puttlitz, Christian M.; From, Robert P.; Todd, Michael M.

2014-01-01

Introduction Laryngoscopy and endotracheal intubation in the presence of cervical spine instability may put patients at risk of cervical cord injury. Nevertheless, the biomechanics of intubation (cervical spine motion as a function of applied force) have not been characterized. This study characterized and compared the relationship between laryngoscope force and cervical spine motion using two laryngoscopes hypothesized to differ in force. Methods Fourteen adults undergoing elective surgery were intubated twice (Macintosh, Airtraq). During each intubation, laryngoscope force, cervical spine motion, and glottic view were recorded. Force and motion were referenced to a pre-intubation baseline (stage 1) and were characterized at three stages: stage 2 (laryngoscope introduction); stage 3 (best glottic view); stage 4 (endotracheal tube in trachea). Results Maximal force and motion occurred at stage 3, and differed between the Macintosh and Airtraq: 1) Force: 48.8±15.8 vs. 10.4±2.8 N, respectively; P=0.0001; 2) occiput-C5 extension: 29.5±8.5 vs. 19.1±8.7 degrees, respectively; P=0.0023. Between stages -2 and -3, the motion/force ratio differed between Macintosh and Airtraq: 0.5±0.2 vs. 2.0±1.4 degrees/N, respectively; P=0.0006. Discussion The relationship between laryngoscope force and cervical spine motion is: 1) non-linear and 2) differs between laryngoscopes. Differences between laryngoscopes in motion/force relationships are likely due to: 1) laryngoscope-specific cervical extension needed for intubation, 2) laryngoscope-specific airway displacement/deformation needed for intubation, and 3) cervical spine and airway tissue viscoelastic properties. Cervical spine motion during endotracheal intubation is not directly proportional to force. Low force laryngoscopes cannot be assumed to result in proportionally low cervical spine motion. PMID:24739996

Glottic airway gain after 'suture arytenoid laterofixation' in bilateral vocal cord paralysis.

PubMed

Korkmaz, Mehmet Hakan; Bayır, Ömer; Tatar, Emel Çadallı; Saylam, Güleser; Öcal, Bülent; Keseroğlu, Kemal; Özdek, Ali

2015-09-01

This method is an easy, non-expensive, and effective technique in bilateral vocal cord paralysis to improve glottic airway and clinical performance. To evaluate the effectiveness of 'suture arytenoid laterofixation' surgery in bilateral vocal cord paralysis. A retrospective analysis of patients' medical history undergoing 'suture arytenoid laterofixation' surgery for bilateral vocal cord paralysis. This technique was applied under general anesthesia with both microlaryngoscopy and video-monitoring. Two 16 g needles and one 1/0 nylon thread were used for the procedure with 1 cm skin incision; no tracheotomy or tissue excision was required. Pre-post-operative photographs of the glottic region were taken from the endoscopic records, and the areas of rima glottis openings were calculated with the Image-J programme. Forty-seven patients were analyzed. The mean pre-post-operative rima glottis areas were 1.11 ± 0.56 and 2.24 ± 0.93 mm(2), respectively (p < 0.001). Five patients with previous tracheotomy were decannulated within a few days after the operation. In three patients, mild complications developed in the early post-operative period (two laryngeal edemas, one submucosal hematoma). Tracheotomy was performed to only one pregnant patient in the post-operative first day. None of the patients had granulation formation or synechia.

Simple Carotid-Sparing Intensity-Modulated Radiotherapy Technique and Preliminary Experience for T1-2 Glottic Cancer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rosenthal, David I., E-mail: dirosenthal@mdanderson.or; Fuller, Clifton D.; Barker, Jerry L.

2010-06-01

Purpose: To investigate the dosimetry and feasibility of carotid-sparing intensity-modulated radiotherapy (IMRT) for early glottic cancer and to report preliminary clinical experience. Methods and Materials: Digital Imaging and Communications in Medicine radiotherapy (DICOM-RT) datasets from 6 T1-2 conventionally treated glottic cancer patients were used to create both conventional IMRT plans. We developed a simplified IMRT planning algorithm with three fields and limited segments. Conventional and IMRT plans were compared using generalized equivalent uniform dose and dose-volume parameters for in-field carotid arteries, target volumes, and organs at risk. We have treated 11 patients with this simplified IMRT technique. Results: Intensity-modulated radiotherapymore » consistently reduced radiation dose to the carotid arteries (p < 0.05) while maintaining the clinical target volume coverage. With conventional planning, median carotid V35, V50, and V63 were 100%, 100%, and 69.0%, respectively. With IMRT planning these decreased to 2%, 0%, and 0%, respectively (p < 0.01). Radiation planning and treatment times were similar for conventional radiotherapy and IMRT. Treatment results have been excellent thus far. Conclusions: Intensity-modulated radiotherapy significantly reduced unnecessary radiation dose to the carotid arteries compared with conventional lateral fields while maintaining clinical target volume coverage. Further experience and longer follow-up will be required to demonstrate outcomes for cancer control and carotid artery effects.« less

Relevant reduction effect with a modified thermoplastic mask of rotational error for glottic cancer in IMRT

NASA Astrophysics Data System (ADS)

Jung, Jae Hong; Jung, Joo-Young; Cho, Kwang Hwan; Ryu, Mi Ryeong; Bae, Sun Hyun; Moon, Seong Kwon; Kim, Yong Ho; Choe, Bo-Young; Suh, Tae Suk

2017-02-01

The purpose of this study was to analyze the glottis rotational error (GRE) by using a thermoplastic mask for patients with the glottic cancer undergoing intensity-modulated radiation therapy (IMRT). We selected 20 patients with glottic cancer who had received IMRT by using the tomotherapy. The image modalities with both kilovoltage computed tomography (planning kVCT) and megavoltage CT (daily MVCT) images were used for evaluating the error. Six anatomical landmarks in the image were defined to evaluate a correlation between the absolute GRE (°) and the length of contact with the underlying skin of the patient by the mask (mask, mm). We also statistically analyzed the results by using the Pearson's correlation coefficient and a linear regression analysis ( P <0.05). The mask and the absolute GRE were verified to have a statistical correlation ( P < 0.01). We found a statistical significance for each parameter in the linear regression analysis (mask versus absolute roll: P = 0.004 [ P < 0.05]; mask versus 3D-error: P = 0.000 [ P < 0.05]). The range of the 3D-errors with contact by the mask was from 1.2% - 39.7% between the maximumand no-contact case in this study. A thermoplastic mask with a tight, increased contact area may possibly contribute to the uncertainty of the reproducibility as a variation of the absolute GRE. Thus, we suggest that a modified mask, such as one that covers only the glottis area, can significantly reduce the patients' setup errors during the treatment.

Trial Vocal Fold Injection Predicts Thyroplasty Outcomes in Nonparalytic Glottic Incompetence.

PubMed

Dumberger, Lukas D; Overton, Lewis; Buckmire, Robert A; Shah, Rupali N

2017-04-01

Trial vocal fold injection (TVFI) may be used prior to permanent medialization when voice outcome is uncertain. We aimed to determine whether voice outcomes of TVFI are predictive of, or correlate with outcomes after type I Gore-Tex medialization thyroplasty (GMT) in patients with nonparalytic glottic incompetence (GI). Thirty-five patients with nonparalytic GI who underwent TVFI followed by GMT were retrospectively reviewed. Change in voice-related quality of life (VRQOL) after TVFI was compared to change in VRQOL 3 to 9 months after GMT. Similar comparisons were made for change in glottal function index (GFI) and change in grade, roughness, breathiness, asthenia, and strain (GRBAS). Sample correlation coefficients were calculated. Change in VRQOL after TVFI showed good correlation with change in VRQOL after GMT, r = 0.55. Change in GFI after TVFI showed strong correlation with change in GFI after GMT, r = 0.74. Change in GRBAS after TVFI showed excellent correlation with change in GRBAS after GMT, r = 0.90. The TVFI is a useful tool in nonparalytic GI when outcomes from glottic closure procedures are not clear. Voice outcome measures after TVFI strongly correlate with outcomes from GMT. These data may be used to more confidently counsel patients regarding their predicted outcomes of permanent medialization.

Study of the Histopathologic Characteristics and Surface Morphologies of Glottic Carcinomas With Anterior Vocal Commissure Involvement.

PubMed

Wu, Jianhui; Zhao, Jing; Wang, Zhangfeng; Li, Zenghong; Luo, Jie; Liao, Bing; Yang, Zhiyun; Liu, Qihong; Wang, Bin; Wen, Weiping; Lei, Wenbin

2015-07-01

This article explores the features and the role of the anterior vocal commissure (AVC) structure and the surface morphologies of glottic carcinomas with AVC involvement to provide a reference for the selection of transoral carbon dioxide (CO2) laser surgery. A total of 31 cases of glottic carcinomas with AVC involvement from May 2012 to January 2014 were included. All patients underwent electronic laryngoscopic examinations and computed tomography scans to determine the surface morphology. After surgery, the tumor specimens were resected integrally, and axial serial sections parallel to the plane of vocal cords were taken to explore the features and possible invasion paths of the glottic carcinomas with AVC involvement. The rates of involvement of the supraglottis and subglottis were 71.4% and 14.8%, respectively, via the AVC. The involvement of the superficial layer of the unilateral or bilateral vocal cords without involvement of the vocal muscle in the AVC region (IVM) or the cartilage was present in 15 cases (48.4%). The involvement of the superficial layer of the unilateral and bilateral vocal cords occurred in 16 cases (51.6%) with the IVM in 13 cases and the involvement of the intermediate lamina of the thyroid cartilage (ITC) in 8 cases. The involvement of the ITC was associated with the involvement of the vocal muscle of the AVC region (P < 0.05). Among the pushing carcinomas, 15 of 21 (71.4%) presented with well-defined tumor mass, and 8 of 10 (80.0%) infiltrating carcinomas presented with multiple tumor nests that were often surrounded by fibrosis (P < 0.05). The AVC is an important path of invasion of subglottic in glottic carcinomas but less so for suparglottic. The Broyles' ligaments acted as a barrier against the spread of the tumors to the thyroid cartilage, but this role was obviously weaken by the involvement of the vocal muscle of the AVC region. The infiltrating carcinomas presented with multiple tumor nests in fibrous tissue. When CO2 laser microsurgery is considered as a treatment option, these facts should be kept in mind.

Study of the Histopathologic Characteristics and Surface Morphologies of Glottic Carcinomas With Anterior Vocal Commissure Involvement

PubMed Central

Wu, Jianhui; Zhao, Jing; Wang, Zhangfeng; Li, Zenghong; Luo, Jie; Liao, Bing; Yang, Zhiyun; Liu, Qihong; Wang, Bin; Wen, Weiping; Lei, Wenbin

2015-01-01

Abstract This article explores the features and the role of the anterior vocal commissure (AVC) structure and the surface morphologies of glottic carcinomas with AVC involvement to provide a reference for the selection of transoral carbon dioxide (CO2) laser surgery. A total of 31 cases of glottic carcinomas with AVC involvement from May 2012 to January 2014 were included. All patients underwent electronic laryngoscopic examinations and computed tomography scans to determine the surface morphology. After surgery, the tumor specimens were resected integrally, and axial serial sections parallel to the plane of vocal cords were taken to explore the features and possible invasion paths of the glottic carcinomas with AVC involvement. The rates of involvement of the supraglottis and subglottis were 71.4% and 14.8%, respectively, via the AVC. The involvement of the superficial layer of the unilateral or bilateral vocal cords without involvement of the vocal muscle in the AVC region (IVM) or the cartilage was present in 15 cases (48.4%). The involvement of the superficial layer of the unilateral and bilateral vocal cords occurred in 16 cases (51.6%) with the IVM in 13 cases and the involvement of the intermediate lamina of the thyroid cartilage (ITC) in 8 cases. The involvement of the ITC was associated with the involvement of the vocal muscle of the AVC region (P < 0.05). Among the pushing carcinomas, 15 of 21 (71.4%) presented with well-defined tumor mass, and 8 of 10 (80.0%) infiltrating carcinomas presented with multiple tumor nests that were often surrounded by fibrosis (P < 0.05). The AVC is an important path of invasion of subglottic in glottic carcinomas but less so for suparglottic. The Broyles’ ligaments acted as a barrier against the spread of the tumors to the thyroid cartilage, but this role was obviously weaken by the involvement of the vocal muscle of the AVC region. The infiltrating carcinomas presented with multiple tumor nests in fibrous tissue. When CO2 laser microsurgery is considered as a treatment option, these facts should be kept in mind. PMID:26200618

Risk of fatal cerebrovascular accidents after external beam radiation therapy for early-stage glottic laryngeal cancer.

PubMed

Swisher-McClure, Samuel; Mitra, Nandita; Lin, Alexander; Ahn, Peter; Wan, Fei; O'Malley, Bert; Weinstein, Gregory S; Bekelman, Justin E

2014-05-01

This study compared the risk of fatal cerebrovascular accidents (CVAs) in patients with early-stage glottic laryngeal cancer receiving surgery or external beam radiation therapy (EBRT). Using a competing risks survival analysis, we compared the risk of death because of CVA among patients with early-stage glottic laryngeal cancer receiving surgery or EBRT in the Surveillance, Epidemiology, and End Results (SEER) database. The cumulative incidence of fatal CVA at 15 years was higher in patients receiving EBRT (2.8%; 95% confidence interval [CI], 2.3% to 3.4%) compared to surgery (1.5%; 95% CI, 0.8% to 2.3%; p = .024). In multivariable competing risks regression models, EBRT remained associated with an increased risk of fatal CVA compared to surgery (adjusted hazard ratio [HR], 1.75; 95% CI, 1.04-2.96; p = .037). Treatment for early-stage glottic laryngeal cancer with EBRT was associated with a small increase in the risk of late fatal CVA events relative to surgery. Copyright © 2013 Wiley Periodicals, Inc.

Comparison of the McGrath® Series 5 and GlideScope® Ranger with the Macintosh laryngoscope by paramedics

PubMed Central

2011-01-01

Background Out-of-hospital endotracheal intubation performed by paramedics using the Macintosh blade for direct laryngoscopy is associated with a high incidence of complications. The novel technique of video laryngoscopy has been shown to improve glottic view and intubation success in the operating room. The aim of this study was to compare glottic view, time of intubation and success rate of the McGrath® Series 5 and GlideScope® Ranger video laryngoscopes with the Macintosh laryngoscope by paramedics. Methods Thirty paramedics performed six intubations in a randomised order with all three laryngoscopes in an airway simulator with a normal airway. Subsequently, every participant performed one intubation attempt with each device in the same manikin with simulated cervical spine rigidity using a cervical collar. Glottic view, time until visualisation of the glottis and time until first ventilation were evaluated. Results Time until first ventilation was equivalent after three intubations in the first scenario. In the scenario with decreased cervical motion, the time until first ventilation was longer using the McGrath® compared to the GlideScope® and AMacintosh (p < 0.01). The success rate for endotracheal intubation was similar for all three devices. Glottic view was only improved using the McGrath® device (p < 0.001) compared to using the Macintosh blade. Conclusions The learning curve for video laryngoscopy in paramedics was steep in this study. However, these data do not support prehospital use of the McGrath® and GlideScope® devices by paramedics. PMID:21241469

The effect of changing the sequence of cuff inflation and device fixation with the LMA-Supreme® on device position, ventilatory complications, and airway morbidity: a clinical and fiberscopic study.

PubMed

Bergmann, Ingo; Crozier, Thomas Allen; Roessler, Markus; Schotola, Hanna; Mansur, Ashham; Büttner, Benedikt; Hinz, José Maria; Bauer, Martin

2014-01-04

The conventional sequence when using supraglottic airway devices is insertion, cuff inflation and fixation. Our hypothesis was that a tighter fit of the cuff and tip could be achieved with a consequently lower incidence of air leak, better separation of gastrointestinal and respiratory tracts and less airway morbidity if the device were first affixed and the cuff then inflated. Our clinical review board approved the study (public registry number DRKS00003174). An LMA Supreme® was inserted into 184 patients undergoing lower limb arthroscopy in propofol-remifentanil anaesthesia who were randomly assigned to either the control (inflation then fixation; n = 92) or study group (fixation then inflation; n = 92). The cuff was inflated to 60 cmH2O. The patients' lungs were ventilated in pressure-controlled mode with 5 cmH2O PEEP, Pmax to give 6 ml kg-1 tidal volume, and respiratory rate adjusted to end-tidal CO2 of 4.8 and 5.6 kPa. Correct cuff and tip position were determined by leak detection, capnometry trace, oropharyngeal leak pressure, suprasternal notch test, and lube-tube test. Bowl and cuff position and the presence of glottic narrowing were assessed by fiberscopic examination. Postoperative dysphagia, hoarseness and sore throat were assessed with a questionnaire. Ventilatory impairment was defined as a tidal volume < 6 ml kg-1 with Pmax at oropharyngeal leak pressure, glottic narrowing was defined as an angle between the vocal cords under 16 degrees. The incidence of incorrect device position (18% vs. 21%), failed ventilation (10% vs. 9%), leak pressure (24.8 vs. 25.2 cmH2O, p = 0.63), failed lube-tube test (16.3% vs. 17.6%) and glottic narrowing (19.3% vs. 14.1%, p = 0.35) was similar in both groups (control vs. study, resp.). When glottic narrowing occurred, it was more frequently associated with ventilatory impairment in the control group (77% vs. 39%; p = 0.04). Airway morbidity was more common in the control group (33% vs. 19%; p < 0.05). Altering the sequence of cuff inflation and device fixation does not affect device position, oropharyngeal leak pressures or separation of gastrointestinal and respiratory tracts. It reduces the incidence of glottic narrowing with impaired ventilation and also perioperative airway morbidity.

Tracheal intubation in the ice-pick position with video laryngoscopes: a randomised controlled trial in a manikin.

PubMed

Wetsch, Wolfgang A; Hellmich, Martin; Spelten, Oliver; Schier, Robert; Böttiger, Bernd W; Hinkelbein, Jochen

2013-09-01

Tracheal intubation in nonstandardised positions is associated with a higher risk of tube misplacement and may have deleterious consequences for patients. Video laryngoscopes for tracheal intubation facilitate both glottic view and success rates. However, their use in the ice-pick position has not been evaluated. To evaluate the role of video laryngoscopes for tracheal intubation in the ice-pick position. A randomised, controlled manikin trial. A standardised airway manikin was placed in the corner of a room. Tracheal intubation was only possible from the lower right side of the manikin. In randomised order, participants used a standard Macintosh laryngoscope and GlideScope Ranger, Storz C-MAC, Pentax AWS, Airtraq and McGrath Series5 video laryngoscopes. Statistical analysis was performed using the Wilcoxon signed-rank and McNemar's tests; A P value of less than 0.05 was deemed statistically significant. Twenty anaesthesiologists, all emergency medicine board-certified. Time to first ventilation (primary); time to glottic view and confirmation of tube position (secondary). Successful ventilation was achieved most rapidly with the Macintosh laryngoscope (36.1 ± 13.4 s; reference method), followed by the Airtraq (38.4 ± 36.3 s; P = n.s.), Pentax AWS (51.6 ± 43.3 s; P = n.s.) and Storz C-Mac (62.7 ± 49.7 s; P = n.s.). The use of the GlideScope Ranger (79.8 ± 61.9 s, P = 0.01) and McGrath series5 (79.8 ± 58.5 s, P = 0.023) resulted in significantly longer times. When comparing overall intubation success, the rate of successful tracheal intubation was higher with the Airtraq than with the McGrath Series5 (P = 0.031; all others n.s.). The use of video laryngoscopes did not result in higher success rates or faster tracheal intubation in the ice-pick position when compared with conventional laryngoscopy in this manikin study. www.clinicaltrials.gov, NCT01210105.

CO2 laser versus cold steel margin analysis following endoscopic excision of glottic cancer

PubMed Central

2014-01-01

Objective To compare the suitability of CO2 laser with steel instruments for margin excision in transoral laser microsurgery. Methods Prospective randomized blinded study. Patients with glottic cancer undergoing laser resection were randomized to margin excision by either steel instruments or CO2 laser. Margins were analyzed for size, interpretability and degree of artifact by a pathologist who was blinded to technique. Results 45 patients were enrolled in the study with 226 total margins taken. 39 margins taken by laser had marked artifact and 0 were uninterpretable. 20 margins taken by steel instruments had marked artifact, and 2 were uninterpretable. Controlling for margin size, the laser technique was associated with increasing degrees of margin artifact (p = 0.210), but there was no difference in crude rates of uninterpretability (p = 0.24). Conclusion Laser margin excision is associated with a greater degree of artifact than steel instrument excision, but was not associated with higher rate of uninterpretability. PMID:24502856

Definitive hypofractionated radiotherapy for early glottic carcinoma: experience of 55Gy in 20 fractions.

PubMed

Ermiş, Ekin; Teo, Mark; Dyker, Karen E; Fosker, Chris; Sen, Mehmet; Prestwich, Robin Jd

2015-09-23

A wide variety of fractionation schedules have been employed for the treatment of early glottic cancer. The aim is to report our 10-year experience of using hypofractionated radiotherapy with 55Gy in 20 fractions at 2.75Gy per fraction. Patients treated between 2004 and 2013 with definitive radiotherapy to a dose of 55Gy in 20 fractions over 4 weeks for T1/2 N0 squamous cell carcinoma of the glottis were retrospectively identified. Patients with prior therapeutic minor surgery (eg. laser stripping, cordotomy) were included. The probabilities of local control, ultimate local control (including salvage surgery), regional control, cause specific survival (CSS) and overall survival (OS) were calculated. One hundred thirty-two patients were identified. Median age was 65 years (range 33-89). Median follow up was 72 months (range 7-124). 50 (38 %), 18 (14 %) and 64 (48 %) of patients had T1a, T1b and T2 disease respectively. Five year local control and ultimate local control rates were: overall - 85.6 % and 97.3 % respectively, T1a - 91.8 % and 100 %, T1b - 81.6 and 93.8 %, and T2 - 80.9 % and 95.8 %. Five year regional control, CSS and OS rates were 95.4 %, 95.7 % and 78.8 % respectively. There were no significant associations of covariates (e.g. T-stage, extent of laryngeal extension, histological grade) with local control on univariate analysis. Only increasing age and transglottic extension in T2 disease were significantly associated with overall survival (both p <0.01). Second primary cancers developed in 17 % of patients. 13 (9.8 %) of patients required enteral tube feeding support during radiotherapy; no patients required long term enteral nutrition. One patient required a tracheostomy due to a non-functioning larynx on long term follow up. Hypofractionated radiation therapy with a dose of 55Gy in 20 fractions for early stage glottic cancer provides high rates of local control with acceptable toxicity.

Comparison of the Pentax AirwayScope and McGrath MAC videolaryngoscope for endotracheal intubation in patients with a normal airway

PubMed Central

Lee, Jiyoung; Kwak, Hyun Jeong; Lee, Ji Yeon; Chang, Min Young; Lee, Sook Young; Kim, Jong Yeop

2017-01-01

Abstract Various videolaryngoscopes (VLs) have been developed to provide a better laryngeal view and facilitate difficult intubations. The goal of this study was to compare 2 VLs, the Pentax AWS and the McGrath VL, with respect to intubation time and ease of intubation. One hundred forty patients aged 19 to 65 years (American Society of Anesthesiologists classification I or II), who required tracheal intubation for elective surgery, were randomly assigned to 1 of the 2 groups: the Pentax AWS (n = 70) or the McGrath VL (n = 70). The primary outcome was time to intubation (TTI) measured by a blind observer. The intubation difficulty scale (IDS), percentage of glottic opening (POGO) scale, glottic grade, use of optimal external laryngeal manipulation (OELM), and ease of intubation were also recorded. The Pentax AWS provided a better laryngeal view than the McGrath VL with respect to the Cormack-Lehane (CL) glottic grade (1/2a/2b) (63/7/0 vs 43/24/3, P < .001) and the POGO scale (median [interquartile range, IQR]) (100 [100–100] vs 100 [80–100], P < .001). The IDS was significantly lower in the Pentax AWS group compared with the McGrath VL group (median [IQR]) (0 [0–0] vs 0 [0–1], P < .001). However, the TTI was similar in both the Pentax AWS and McGrath VL groups (median [IQR]) (30 [27–34] vs 32 [27–35] seconds, P = .440). OELM and ease of intubation were also similar between the 2 groups. The Pentax AWS offered a superior laryngeal view compared with the McGrath VL. There was no significant difference in either the intubation time or ease of intubation using these 2 devices in patients with normal airways. PMID:29145308

Intraoperative narrow band imaging better delineates superficial resection margins during transoral laser microsurgery for early glottic cancer.

PubMed

Garofolo, Sabrina; Piazza, Cesare; Del Bon, Francesca; Mangili, Stefano; Guastini, Luca; Mora, Francesco; Nicolai, Piero; Peretti, Giorgio

2015-04-01

The high rate of positive margins after transoral laser microsurgery (TLM) remains a matter of debate. This study investigates the effect of intraoperative narrow band imaging (NBI) examination on the incidence of positive superficial surgical margins in early glottic cancer treated by TLM. Between January 2012 and October 2013, 82 patients affected by Tis-T1a glottic cancer were treated with TLM by type I or II cordectomies. Intraoperative NBI evaluation was performed using 0-degree and 70-degree rigid telescopes. Surgical specimens were oriented by marking the superior edge with black ink and sent to a dedicated pathologist. Comparison between the rate of positive superficial margins in the present cohort and in a matched historical control group treated in the same way without intraoperative NBI was calculated by chi-square test. At histopathological examination, all surgical margins were negative in 70 patients, whereas 7 had positive deep margins, 2 close, and 3 positive superficial margins. The rate of positive superficial margins was thus 3.6% in the present group and 23.7% in the control cohort (P<.001). Routine use of intraoperative NBI increases the accuracy of neoplastic superficial spreading evaluation during TLM for early glottic cancer. © The Author(s) 2014.

Straight video blades are advantageous than curved blades in simulated pediatric difficult intubation.

PubMed

Saracoglu, Kemal T; Eti, Zeynep; Kavas, Ayse D; Umuroglu, Tumay

2014-03-01

It is still controversial which laryngoscope may be a better option in unanticipated difficult airway in pediatric patients. The aim of the present study was to compare two direct and two video-assisted laryngoscope devices for the management of difficult pediatric airway. Forty-five anesthesiology residents and nurse anesthetists participated in the study. Macintosh, Miller, Storz Miller, and McGrath Mac curved laryngoscopes were used for tracheal intubation of 3-6-month Airsim Pierre Robin manikin. We compared the duration of successful intubation, number of attempts, glottic view grades, severity of dental trauma, the use of optimization maneuvers, and the difficulty of use of the devices with straight and curved laryngoscope blades. Successful intubation duration was significantly lower in Storz Miller device, and the number of intubation attempts was significantly higher in the Macintosh laryngoscope (P < 0.01). According to the Cormack and Lehane classification, Grades 1 and 2 glottic view was 20% for Macintosh and 40% for Miller laryngoscope, while it was 100% for Storz Miller and 80% for McGrath (P < 0.001). Difficulty VAS scores of Storz Miller device were significantly lower than the scores of Macintosh, Miller, and McGrath laryngoscopes (15.7 ± 14.89, 34.7 ± 26.44, 31.5 ± 26.74, 33.4 ± 26.67 mm, respectively; P < 0.01). The severity of dental trauma was significantly lower in Storz Miller compared with Macintosh, Miller, and McGrath laryngoscopes (0.96 ± 1.04, 1.67 ± 1.15, 1.38 ± 1.05, 1.42 ± 1.27, respectively; P < 0.01). Storz Miller laryngoscope was found to have advantages over the other laryngoscopes in regard to glottic view, duration of successful intubation, number of attempts, dental trauma severity, need for additional maneuvers, and ease of use. © 2013 John Wiley & Sons Ltd.

Comparison of glottic visualisation and ease of intubation with different laryngoscope blades.

PubMed

Kulkarni, Atul P; Tirmanwar, Amar S

2013-03-01

Literature suggests glottic view is better with straight blades while tracheal intubation is easier with curved blades. To compare glottic view and ease of intubation with Macintosh, Miller, McCoy blades and the Trueview(®) laryngoscope. This prospective randomised study was undertaken in operation theatres of a 550 bedded tertiary referral cancer centre after approval from the Institutional Review Board. We compared the Macintosh, Miller, McCoy blades and the Trueview(®) laryngoscope for glottic visualisation and ease of tracheal intubation; in 120 patients undergoing elective cancer surgery; randomly divided into four groups. After induction of anaesthesia laryngoscopy was performed and trachea intubated. We recorded: Visualisation of glottis (Cormack Lehane grade), ease of intubation, number of attempts; need to change the blade and need for external laryngeal manipulation. Demographic data, Mallampati classification were compared using the Chi-square test. A P<0.05 was considered significant. Grade 1 view was obtained most often (87% patients) with Trueview(®) laryngoscope. Intubation was easier (Grade 1) with Trueview(®) and McCoy blades (93% each). Seven patients needed two attempts; one patient in Miller group needed three attempts. No patient in McCoy and Trueview(®) Groups required external laryngeal manipulation. We found that in patients with normal airway glottis was best visualised with Miller blade and Trueview(®) laryngoscope however, the trachea was more easily intubated with McCoy and Macintosh blades and Trueview(®) laryngoscope.

Tracheal intubation in patients with cervical spine immobilization: A comparison of McGrath(®) video laryngoscope and Truview EVO2(®) laryngoscope.

PubMed

Bhola, Ruchi; Bhalla, Swaran; Gupta, Radha; Singh, Ishwar; Kumar, Sunil

2014-05-01

Literature suggests that glottic view is better when using McGrath(®) Video laryngoscope and Truview(®) in comparison with McIntosh blade. The purpose of this study was to evaluate the effectiveness of McGrath Video laryngoscope in comparison with Truview laryngoscope for tracheal intubation in patients with simulated cervical spine injury using manual in-line stabilisation. This prospective randomised study was undertaken in operation theatre of a tertiary referral centre after approval from the Institutional Review Board. A total of 100 consenting patients presenting for elective surgery requiring tracheal intubation were randomly assigned to undergo intubation using McGrath(®) Video laryngoscope (n = 50) or Truview(®) (n = 50) laryngoscope. In all patients, we applied manual-in-line stabilisation of the cervical spine throughout the airway management. Statistical testing was conducted with the statistical package for the social science system version SPSS 17.0. Demographic data, airway assessment and haemodynamics were compared using the Chi-square test. A P < 0.05 was considered significant. The time to successful intubation was less with McGrath video laryngoscope when compared to Truview (30.02 s vs. 38.72 s). However, there was no significant difference between laryngoscopic views obtained in both groups. The number of second intubation attempts required and incidence of complications were negligible with both devices. Success rate of intubation with both devices was 100%. Intubation with McGrath Video laryngoscope caused lesser alterations in haemodynamics. Both laryngoscopes are reliable in case of simulated cervical spine injury using manual-in-line stabilisation with 100% success rate and good glottic view.

Surgical Treatment of Iatrogenic Ventral Glottic Stenosis Using a Mucosal Flap Technique

PubMed Central

Barnett, Timothy P.; O'Leary, John Mark; Dixon, Padraic M.

2016-01-01

Objective To describe a novel surgical technique for correcting postoperative ventral glottic stenosis (cicatrix or web formation) and the outcome in 2 Thoroughbred racehorses. Study Design Retrospective case report. Animals Thoroughbreds diagnosed with ventral glottic stenosis (n=2). Methods Horses presenting with iatrogenic ventral glottic stenosis and resultant exercise intolerance and abnormal exercise‐related noise were anesthetized and a midline sagittal skin incision was made over the ventral larynx and between the sternohyoideus muscles overlying the cricothyroid notch. The cricothyroid ligament, attached laryngeal cicatrix, and overlying mucosa were sagittally sectioned at the dorsal aspect of the cicatrix on the left side. The laryngeal mucosa, cicatrix, and underlying cricothyroid ligament immediately rostral and caudal to the cicatrix were sectioned in a medial (axial) direction as far as the right side of the cricothyroid notch. After resection of the majority of the attached cicatrix tissue, the residual mucosal flap (attached to the right side of the larynx) was reflected ventrally and sutured to the attachment of the cricothyroid ligament on the right side of the cricothyroid notch, creating an intact mucosal layer on the right side of the ventral larynx. Results Both horses had good intralaryngeal wound healing with minimal redevelopment of ventral glottic stenosis at 5 and 9 months postoperatively and were successfully returned to racing with complete absence of abnormal respiratory noise. Conclusion The unique laryngeal anatomy of horses, with a cartilage‐free ventral laryngeal area (cricothyroid notch), allowed the use of this novel surgical technique to successfully treat ventral glottic stenosis. PMID:27013024

DOE Office of Scientific and Technical Information (OSTI.GOV)

Camingue, Pamela; Christian, Rochelle; Ng, Davin

The purpose of this study was to compare 4 different external beam radiation therapy treatment techniques for the treatment of T1-2, N0, M0 glottic cancers: traditional lateral beams with wedges (3D), 5-field intensity-modulated radiation therapy (IMRT), volumetric modulated arc therapy (VMAT), and proton therapy. Treatment plans in each technique were created for 10 patients using consistent planning parameters. The photon treatment plans were optimized using Philips Pinnacle{sub 3} v.9 and the IMRT and VMAT plans used the Direct Machine Parameter Optimization algorithm. The proton treatment plans were optimized using Varian Eclipse Proton v.8.9. The prescription used for each plan wasmore » 63 Gy in 28 fractions. The contours for spinal cord, right carotid artery, left carotid artery, and normal tissue were created with respect to the patient's bony anatomy so that proper comparisons of doses could be made with respect to volume. An example of the different isodose distributions will be shown. The data collection for comparison purposes includes: clinical treatment volume coverage, dose to spinal cord, dose to carotid arteries, and dose to normal tissue. Data comparisons will be displayed graphically showing the maximum, mean, median, and ranges of doses.« less

Whistle register: a preliminary investigation by HSDI visualization and acoustics on female cases

NASA Astrophysics Data System (ADS)

Di Corcia, Antonio; Fussi, Franco

2012-02-01

In this study we investigated laryngeal behaviors involved during vocal production of highest female vocal ranges in Flute in M3 Register, in Whistle Register and in a newly formulated by us, Hiss Register. Observations were carried with stroboscopy and High Speed Digital Imaging and with spectrographic and psycho-acoustic analysis by means of a software system having a wide spectral range (0-20.000 Hz). Results indicate that at the highest pitch vocal folds vibration is absent or significantly reduced, glottic contact is incomplete. These acoustic form of extreme pitch levels comprised intra-harmonic noise and overtones within 10 to 18 kHz range.

Comparison of survival between radiation therapy and trans-oral laser microsurgery for early glottic cancer patients; a retrospective cohort study.

PubMed

De Santis, R J; Poon, I; Lee, J; Karam, I; Enepekides, D J; Higgins, K M

2016-08-02

The literature reports various treatment methodologies, such as trans-oral laser microsurgery, radiation therapy, total/partial laryngectomies, and concurrent radiation chemotherapy for patients with early larynx cancer. However, at the forefront of early glottis treatment is trans-oral laser microsurgery and radiation therapy, likely due to better functional and survival outcomes. Here we conduct the largest Canadian head-to-head comparison of consecutive patients treated with either radiation therapy or trans-oral laser microsurgery. Additionally, we compare these two treatments and their 5-year survival rates post treatment to add to the existing literature. Charts of patients who were diagnosed with early glottic cancer between 2006 and 2013 were reviewed. Seventy-five patients were identified, and split into 2 groups based on their primary treatment, trans-oral laser microsurgery and radiation therapy. Kaplan-Meier survival curves, life-tables, and the log-rank statistic were reported to determine if there was a difference between the two treatment groups and their disease-specific survival, disease-free survival, and total laryngectomy-free survival. Additionally, each different survival analysis was stratified by potential confounding variables, to help conclude which treatment is more efficacious in this population. The 5-year disease-specific survival rate is 93.3 % σ = 0.063 and 90.8 % σ = 0.056 for patients treated with trans-oral laser microsurgery and radiation therapy, respectively (χ (2) < 0.001, p = 0.983). The disease free survival rate is 60.0 % (σ =0.121) for patients treated with trans-oral laser microsurgery, and 67.2 % (σ = 0.074) for those who received RT (χ (2) = 0.19, p = 0.663). Additionally, the total laryngectomy-free survival rate is 84.1 % (σ = 0.1) and 79.1 % (σ = 0.072) for patients' early glottic cancer treated by trans-oral laser microsurgery and radiation therapy, respectively (χ (2) = 0.235, p = 0.628). Chi-square analysis of age-group versus treatment group (χ (2) = 6.455, p = 0.04) and T-stage versus treatment group (χ (2) = 11.3, p = 0.001) revealed a statistically significant relationship, suggesting survival analysis should be stratified by these variables. However, after stratification, there was no statistically significant difference between the trans-oral laser microsurgery and radiation therapy groups in any of the survival analyses. No difference was demonstrated in the 5-year disease-specific survival, disease-free survival, and total laryngectomy-free survival, between the RT and TLM treatment groups. Additionally, both groups showed similar 5-year survival after stratifying by confounding variables.

Utility approach to decision-making in extended T1 and limited T2 glottic carcinoma.

PubMed

van Loon, Yda; Stiggelbout, Anne M; Hakkesteegt, Marieke M; Langeveld, Ton P M; de Jong, Rob J Baatenburg; Sjögren, Elisabeth V

2017-04-01

It is still undecided if endoscopic laser surgery or radiotherapy is the preferable treatment in extended T1 and limited T2 glottic tumors. Health utilities assessed from patients can aid in decision-making. Patients treated for extended T1 or limited T2 glottic carcinoma by laser surgery (n = 12) or radiotherapy (n = 14) assigned health utilities using a visual analog scale (VAS), time tradeoff (TTO) technique and scored their voice handicap using the Voice Handicap Index (VHI). VAS and TTO scores were slightly lower for the laser group compared to the radiotherapy group, however, not significantly so. The VHI showed a correlation with the VAS score, which was very low in both groups and can be considered (near) normal. Patients show no clear preference for the outcomes of laser surgery or radiotherapy from a quality of life (QOL) or voice handicap point of view. These data can now be incorporated into decision-making models. © 2017 Wiley Periodicals, Inc. Head Neck, 2017 © 2016 Wiley Periodicals, Inc. Head Neck 39: 779-785, 2017. © 2017 Wiley Periodicals, Inc.

Retrograde light-guided laryngoscopy for tracheal intubation: clinical practice and comparison with conventional direct laryngoscopy.

PubMed

Yang, Tao; Hou, Jiong; Li, Jinbao; Zhang, Xu; Zhu, Xiaoyan; Ni, Wen; Mao, Yanfei; Deng, Xiaoming

2013-05-01

Tracheal intubation with conventional laryngoscopy requires many trials until beginners are sufficiently skilled in intubating patients safely. To facilitate intubation, the authors used retrograde light-guided laryngoscopy (RLGL) and compared its feasibility with conventional direct laryngoscopy (DL). Twenty operators participated in a prospective, randomized, open-label, parallel-arm study. These operators intubated 205 patients randomly according to a computer-generated procedure by using either DL or RLGL (five intubations with each technique). The primary outcome was the success rate of tracheal intubation. The authors evaluated the success rate of tracheal intubation, the time to glottic exposure and tracheal intubation, and the Cormack and Lehane grades. Compared with DL, the success rate was greater in the RLGL group for all five intubations (72% vs. 47%; rate difference, 25%; 95% CI [11.84-38.16%], P < 0.001). This was associated with a shorter time to glottic exposure (median [25th and 75th percentile]; 27 [15; 42] vs. 45 [30; 73] s, P < 0.001), shorter intubation time (66 [44; 120] vs. 120 [69; 120] s, P < 0.001), and decreased throat soreness (mean ± SD; visual analog scale, 2.1 ± 0.9 vs. 3.7 ± 1.0 cm, P = 0.001) in the RLGL group compared to the DL group. RLGL is an alternative intubation technique. In our study, it enables beginners to intubate patients more successfully and quickly than conventional DL.

[A comparison of various supraglottic airway devices for fiberoptical guided tracheal intubation].

PubMed

Metterlein, Thomas; Dintenfelder, Anna; Plank, Christoph; Graf, Bernhard; Roth, Gabriel

Fiberoptical assisted intubation via placed supraglottic airway devices has been described as safe and easy procedure to manage difficult airways. However visualization of the glottis aperture is essential for fiberoptical assisted intubation. Various different supraglottic airway devices are commercially available and might offer different conditions for fiberoptical assisted intubation. The aim of this study was to compare the best obtainable view of the glottic aperture using different supraglottic airway devices. With approval of the local ethics committee 52 adult patients undergoing elective anesthesia were randomly assigned to a supraglottic airway device (Laryngeal Tube, Laryngeal Mask Airway I-Gel, Laryngeal Mask Airway Unique, Laryngeal Mask Airway Supreme, Laryngeal Mask Airway Aura-once). After standardized induction of anaesthesia the supraglottic airway device was placed according to the manufacturers recommendations. After successful ventilation the position of the supraglottic airway device in regard to the glottic opening was examined with a flexible fiberscope. A fully or partially visible glottic aperture was considered as suitable for fiberoptical assisted intubation. Suitability for fiberoptical assisted intubation was compared between the groups (H-test, U-test; p<0.05). Demographic data was not different between the groups. Placement of the supraglottic airway device and adequate ventilation was successful in all attempts. Glottic view suitable for fiberoptical assisted intubation differed between the devices ranging from 40% for the laringeal tube (LT), 66% for the laryngeal mask airway Supreme, 70% for the Laryngeal Mask Airway I-Gel and 90% for both the Laryngeal Mask Airway Unique and the Laryngeal Mask Airway Aura-once. None of the used supraglottic airway devices offered a full or partial glottic view in all cases. However the Laryngeal Mask Airway Unique and the Laryngeal Mask Airway Aura-once seem to be more suitable for fiberoptical assisted intubation compared to other devices. Copyright © 2016 Sociedade Brasileira de Anestesiologia. Publicado por Elsevier Editora Ltda. All rights reserved.

A comparison of various supraglottic airway devices for fiberoptical guided tracheal intubation.

PubMed

Metterlein, Thomas; Dintenfelder, Anna; Plank, Christoph; Graf, Bernhard; Roth, Gabriel

Fiberoptical assisted intubation via placed supraglottic airway devices has been described as safe and easy procedure to manage difficult airways. However visualization of the glottis aperture is essential for fiberoptical assisted intubation. Various different supraglottic airway devices are commercially available and might offer different conditions for fiberoptical assisted intubation. The aim of this study was to compare the best obtainable view of the glottic aperture using different supraglottic airway devices. With approval of the local ethics committee 52 adult patients undergoing elective anesthesia were randomly assigned to a supraglottic airway device (Laryngeal Tube, Laryngeal Mask Airway I-Gel, Laryngeal Mask Airway Unique, Laryngeal Mask Airway Supreme, Laryngeal Mask Airway Aura-once). After standardized induction of anesthesia the supraglottic airway device was placed according to the manufacturers recommendations. After successful ventilation the position of the supraglottic airway device in regard to the glottic opening was examined with a flexible fiberscope. A fully or partially visible glottic aperture was considered as suitable for fiberoptical assisted intubation. Suitability for fiberoptical assisted intubation was compared between the groups (H-test, U-test; p<0.05). Demographic data was not different between the groups. Placement of the supraglottic airway device and adequate ventilation was successful in all attempts. Glottic view suitable for fiberoptical assisted intubation differed between the devices ranging from 40% for the laringeal tube (LT), 66% for the laryngeal mask airway Supreme, 70% for the Laryngeal Mask Airway I-Gel and 90% for both the Laryngeal Mask Airway Unique and the Laryngeal Mask Airway Aura-once. None of the used supraglottic airway devices offered a full or partial glottic view in all cases. However the Laryngeal Mask Airway Unique and the Laryngeal Mask Airway Aura-once seem to be more suitable for fiberoptical assisted intubation compared to other devices. Copyright © 2016 Sociedade Brasileira de Anestesiologia. Published by Elsevier Editora Ltda. All rights reserved.

A predictive model for recurrence in patients with glottic cancer implemented in a mobile application for Android.

PubMed

Jover-Esplá, Ana Gabriela; Palazón-Bru, Antonio; Folgado-de la Rosa, David Manuel; Severá-Ferrándiz, Guillermo; Sancho-Mestre, Manuela; de Juan-Herrero, Joaquín; Gil-Guillén, Vicente Francisco

2018-05-01

The existing predictive models of laryngeal cancer recurrence present limitations for clinical practice. Therefore, we constructed, internally validated and implemented in a mobile application (Android) a new model based on a points system taking into account the internationally recommended statistical methodology. This longitudinal prospective study included 189 patients with glottic cancer in 2004-2016 in a Spanish region. The main variable was time-to-recurrence, and its potential predictors were: age, gender, TNM classification, stage, smoking, alcohol consumption, and histology. A points system was developed to predict five-year risk of recurrence based on a Cox model. This was validated internally by bootstrapping, determining discrimination (C-statistics) and calibration (smooth curves). A total of 77 patients presented recurrence (40.7%) in a mean follow-up period of 3.4 ± 3.0 years. The factors in the model were: age, lymph node stage, alcohol consumption and stage. Discrimination and calibration were satisfactory. A points system was developed to obtain the probability of recurrence of laryngeal glottic cancer in five years, using five clinical variables. Our system should be validated externally in other geographical areas. Copyright © 2018 Elsevier Ltd. All rights reserved.

Effect of Medialization Thyroplasty on Glottic Airway Anatomy: Cadaver Model.

PubMed

Shinghal, Tulika; Anderson, Jennifer; Chung, Janet; Hong, Aaron; Bharatha, Aditya

2016-11-01

The purpose of this study was to investigate the change in airway dimensions after medialization thyroplasty (MT) using a cadaveric model. Helical computerized tomography (CT) was performed before and after placement of a silastic block in human larynges to investigate the effect on airway anatomy at the level of the glottis. Tissue density (TD) of the medialized vocal fold (VF) was documented to understand the effect on tissue displacement. This is a cadaveric study. Thirteen human cadaveric larynges underwent fine-cut CT scan before and after MT was performed using carved blocks in two sizes (small block and large block [LB]). Clientstream software was used to measure laryngeal dimensions: intraglottic volume (IGV), cross-sectional area (CSA), posterior-glottic diameter (PGD), VF density (in Hounsfield units [HUs]), and anterior-posterior diameter (APD). Eight sequential axial sections 0.625 mm cuts) at the level of the true VFs were analyzed. There was a significant decrease between the three conditions for IGV (P < 0.0001) and CSA (P < 0.0001). TD of the VF was increased after MT as indicated by HU increase (P = 0.0003). APD was not significantly changed. PGD was significantly different between the no block to LB placement (P = 0.0012). MT significantly changes the IGV and CSA at the level of the glottis. Density in the true VF was significantly increased. These findings have important implications for understanding volumetric effects of MT. Copyright © 2015 The Voice Foundation. Published by Elsevier Inc. All rights reserved.

Contribution of Glottic Insufficiency to Perceived Breathiness in Classically Trained Singers.

PubMed

Graham, Ellen; Angadi, Vrushali; Sloggy, Joanna; Stemple, Joseph

2016-09-01

Breathiness in the singing voice is problematic for classical singers. Voice students and singing teachers typically attribute breathiness to breath management issues and breathing technique. The present study sought to determine whether glottic insufficiency may also contribute to breathiness in a singer's voice. Studies have revealed a relationship between insufficient vocal fold closure and inefficiency in the speaking voice. However, the effect of insufficient vocal fold closure on vocal efficiency in singers has yet to be determined. Two groups of voice students identified with and without breathiness issues underwent aerodynamic and acoustic voice assessment as well as laryngeal stroboscopy of the vocal folds to quantify the prevalence of insufficient vocal fold closure, also known as glottic insufficiency. These assessments revealed four groups: 1) those with glottic insufficiency and no perceived voice breathiness; 2) those with glottic sufficiency and perceived voice breathiness; 3) those with glottic insufficiency and perceived breathiness; and 4) those with glottic sufficiency and no perceived breathiness. Results suggest that previously undiscovered glottal insufficiency is common in young singers, particularly women, though the correlation with identified breathiness was not statistically significant. Acoustic and aerodynamic measures including noise-to-harmonics ratio, maximum phonation time, airflow rate, subglottal pressure, and laryngeal airway resistance were most sensitive to glottic insufficiency.

Dosimetric comparison of helical tomotherapy, intensity-modulated radiation therapy, volumetric-modulated arc therapy, and 3-dimensional conformal therapy for the treatment of T1N0 glottic cancer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ekici, Kemal, E-mail: drkemal06@hotmail.com; Pepele, Eda K.; Yaprak, Bahaddin

2016-01-01

Various radiotherapy planning methods for T1N0 laryngeal cancer have been proposed to decrease normal tissue toxicity. We compare helical tomotherapy (HT), linac-based intensity-modulated radiation therapy (IMRT), volumetric-modulated arc therapy (VMAT), and 3-D conformal radiotherapy (3D-CRT) techniques for T1N0 laryngeal cancer. Overall, 10 patients with T1N0 laryngeal cancer were selected and evaluated. Furthermore, 10 radiotherapy treatment plans have been created for all 10 patients, including HT, IMRT, VMAT, and 3D-CRT. IMRT, VMAT, and HT plans vs 3D-CRT plans consistently provided superior planning target volume (PTV) coverage. Similar target coverage was observed between the 3 IMRT modalities. Compared with 3D-CRT, IMRT, HT,more » and VMAT significantly reduced the mean dose to the carotid arteries. VMAT resulted in the lowest mean dose to the submandibular and thyroid glands. Compared with 3D-CRT, IMRT, HT, and VMAT significantly increased the maximum dose to the spinal cord It was observed that the 3 IMRT modalities studied showed superior target coverage with less variation between each plan in comparison with 3D-CRT. The 3D-CRT plans performed better at the D{sub max} of the spinal cord. Clinical investigation is warranted to determine if these treatment approaches would translate into a reduction in radiation therapy–induced toxicities.« less

Permanent transoral surgery of bilateral vocal fold paralysis: a prospective multi-center trial.

PubMed

Nawka, Tadeus; Sittel, Christian; Gugatschka, Markus; Arens, Christoph; Lang-Roth, Ruth; Wittekindt, Claus; Hagen, Rudolf; Müller, Andreas H; Volk, Gerd F; Guntinas-Lichius, Orlando

2015-06-01

To describe postoperative adverse events (AEs) and outcomes after transoral surgery for bilateral vocal fold paralysis (BVFP). Prospective observational multicenter study. Thirty-six patients with BVFP underwent transoral surgery using standard surgical procedures to unilaterally widen the glottic area. Postoperative adverse events (AEs) including severe adverse events (SAEs) were registered continuously. Pre- and 6-month postoperative evaluations included the 6-Minute Walk Test, the 36-Item Short Form Health Survey (SF-36), the Glasgow Benefit Inventory, the 12-Item Voice Handicap Index (VHI-12), and a Fiberoptic Endoscopic Evaluation of Swallowing graded according to the Penetration-Aspiration-Scale. The patients underwent posterior cordotomy, partial arytenoidectomy, or permanent laterofixation as single procedures or in combination. Forty-seven percent of the patients had postoperative AEs. Dyspnea was the most frequent AE (45%). In 40% of AEs, the events were severe (SAEs), and 72.5% were related to the study intervention. Revision surgery leading to prolonged hospitalization or rehospitalization was necessary in nine cases (25%). Laterofixation was correlated to a decreased risk of AEs (P = 0.042). Six months after surgery, a significant improvement was seen in the SF-domains: Physical component score (P = 0.008), physical functioning (P = 0.001), physical role (P = 0.031), and vitality (P = 0.032). Concerning the voice handicap, only the VHI-12 physical subscore showed a decrease (P = 0.005). The total score and other VHI-12 subscores did not change significantly (all P > 0.05). BCVP patients profit from modern transoral surgery for unilateral glottic widening; quality of life is improved; and the voice is preserved. Nevertheless, postoperative complications are frequent. 2b. © 2015 The American Laryngological, Rhinological and Otological Society, Inc.

Vocal characteristics of congenital anterior glottic webs in children: A case report.

PubMed

Shah, Jay; White, Katherine; Dohar, Joseph

2015-06-01

This case report describes a 5-year-old girl with chronic dysphonia and high-pitched voice since birth. Vocal quality was noted to be harsh. Videostroboscopy revealed significant hyperfunction and a Type II congenital anterior glottic web. Endoscopic division of the anterior glottic web was performed with significant improvement in vocal quality and quality of life. This paper describes methods of analyzing, diagnosing, and treating anterior glottic web with a focus on quality of life. Also, unique acoustic and aerodynamic voice features are identified. No other descriptions of a voice characteristic for anterior glottic web currently exist in the literature. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

A prospective randomized controlled study to evaluate and compare GlideScope with Macintosh laryngoscope for ease of endotracheal intubation in adult patients undergoing elective surgery under general anesthesia

PubMed Central

Jafra, Anudeep; Gombar, Satinder; Kapoor, Dheeraj; Sandhu, Harpreet Singh; Kumari, Kamlesh

2018-01-01

Background: The aim of the study was to compare the ease the intubation using GlideScope video laryngoscope and Macintosh laryngoscope in adult patients undergoing elective surgery under general anesthesia. Materials and Methods: A total of 200 American Society of Anesthesiologists I–II patients of either sex, in the age group of 18–60 years were included in the study. Patients were randomly allocated to two groups. We assessed ease of intubation depending on time to tracheal intubation, number of attempts, glottic view (Cormack–Lehane grade [CL grade] and percentage of glottis opening [POGO]) and intubation difficulty score (IDS), hemodynamic variables and any intra- and post-operative adverse events. Results: The rate of successful endotracheal intubation (ETI) in both groups was 100% in the first attempt. The time required for successful ETI was 24.89 ± 5.574 in Group G and 20.68 ± 3.637 in Group M (P < 0.001) found to be statistically significant. There was significant improvement in glottic view with GlideScope (as assessed by POGO score 66.71 ± 29.929 and 94.40 ± 10.476 in group G and 75.85 ± 26.969 and 74.20 ± 29.514 Group M and CL grading [P < 0.001]). A comparison of mean IDS between two groups revealed intubation was easier with the use of GlideScope. The hemodynamic response to intubation was significantly lesser with the use of GlideScope when compared with Macintosh laryngoscope. The incidence of adverse events, though minor like superficial lip or tongue bleed, was similar in two groups. Conclusions: GlideScope offers superiority over Macintosh laryngoscope in terms of laryngeal views and the difficulty encountered at ETI in an unselected population. PMID:29628839

Evidence-based practice: management of glottic cancer.

PubMed

Hartl, Dana M

2012-10-01

The main issue in the management of glottic squamous cell carcinoma, as for all cancers, is adequate disease control while optimizing functional outcomes and minimizing morbidity. This is true for early-stage disease as for advanced tumors. This article evaluates the current evidence for the diagnostic and pretherapeutic workup for glottic squamous cell carcinoma and the evidence concerning different treatment options for glottic carcinoma, from early-stage to advanced-stage disease. Copyright © 2012 Elsevier Inc. All rights reserved.

Management of vocal fold scar with autologous fat implantation: perceptual results.

PubMed

Neuenschwander, M C; Sataloff, R T; Abaza, M M; Hawkshaw, M J; Reiter, D; Spiegel, J R

2001-06-01

Vocal fold scar disrupts the mucosal wave and interferes with glottic closure. Treatment involves a multidisciplinary approach that includes voice therapy, medical management, and sometimes surgery. We reviewed the records of the first eight patients who underwent autologous fat implantation for vocal fold scar. Information on the etiology of scar, physical findings, and prior interventions were collected. Videotapes of videostroboscopic findings and perceptual voice ratings [Grade, Roughness, Breathiness, Asthenia, Strain (GRBAS)] were randomized and analyzed independently by four blinded observers. Etiology of scar included mass excision (7), vocal fold stripping (3), congenital sulcus (2), and hemorrhage (1). Prior surgical procedures performed included thyroplasty (1), autologous fat injection (9), excision of scar (2), and lysis of adhesions (2). Strobovideolaryngoscopy: Statistically significant improvement was found in glottic closure, mucosal wave, and stiffness (P = 0.05). Perceptual ratings (GRBAS): Statistically significant improvement was found in all five parameters, including overall Grade, Roughness, Breathiness, Asthenia, and Strain (P = 0.05). Patients appear to have improved vocal fold function and quality of voice after autologous fat implantation in the vocal fold. Autologous fat implantation is an important adjunctive procedure in the management of vocal fold scar, and a useful addition to the armamentarium of the experienced phonomicrosurgeon.

Poster — Thur Eve — 57: Evaluation of laryngeal mucosal dose with conventional linac and TomoTherapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nusrat, H; Lekx, K; Eapen, L

2014-08-15

The purpose of this study was to examine whether or not underdosing occurs in the mucosal layer during treatment of glottis cancer. A larynx phantom was produced and regions at risk of recurrence due to suspected underdosing were identified and wells drilled into the phantom for flush placement of TLDs. Seven interest points were chosen. CT simulation was completed prior to the wells being drilled, and again afterwards with the TLD locations indicated using BBs. Treatment plans created for this investigation included: 3DCRT using Elekta-XiO (n=9) and VMAT created using Elekta-Monaco (n=9), both delivered on an Elekta linac; standard TomoTherapymore » plan (n=11) and a directionally blocked TomoTherapy plan to approximate a 3D-conformal approach (n=5). Imaging dose during TomoTherapy deliveries was accounted for. The average TLD result at each interest point was compared to the planned value using a paired t-test. There was no significant difference between the planned and measured 3DCRT dose (268.9 vs. 267.0 cGy, respectively; p>0.05). Similarly, the planned and measured TomoTherapy treatment did not show any significant differences (271.7 vs 269.7 cGy; p>0.05). In the blocked TomoTherapy plan, significant overdosing was seen (274.5 vs 294.9 cGy; p<0.05) and underdosing was not seen in the VMAT treatment (303.5 vs 321.8 cGy; p>0.05). Further investigation is ongoing to ensure appropriate normalization of results and to investigate the overdosing noted with the blocked TomoTherapy plan. Results from this study suggest that significant underdosing does not occur in the conventional treatment of early glottic cancer using 6MV photons.« less

Effects of a sustained inflation in preterm infants at birth.

PubMed

van Vonderen, Jeroen J; Hooper, Stuart B; Hummler, Helmut D; Lopriore, Enrico; te Pas, Arjan B

2014-11-01

To assess the clinical effect of an initial sustained inflation of 10 seconds and 25 cmH2O in preterm infants at birth. In this observational study inflation pressures and tidal volumes were recorded with the use of respiratory function monitoring of preterm infants <32 weeks' gestation receiving a sustained inflation. Inspiratory tidal volume (Vti) and expiratory tidal volume (Vte) of sustained inflation and cumulative Vti and Vte of breaths during sustained inflation were determined. Heart rate and oxygen saturation were measured before and after the sustained inflation. Seventy infants were included (median [IQR]: gestational age 29 [27-30] weeks). Mean (SD) sustained inflation duration was 10.5 seconds (2.9 seconds) with positive inflation pressure 24.2 cmH2O (2.3 cmH2O) and positive end-expiratory pressure 6.0 cmH2O (1.8 cmH2O). In 20 of 70 infants, no volumes were delivered during the sustained inflation because of mask leak. No leak occurred in 50 of 70 infants, of whom 36 of 50 breathed during the sustained inflation. In 14 of the infants who did not breathe, Vti and Vte were 0.9 mL/kg (0.4-2.7 mL/kg) and 0.6 mL/kg (0.1-2.0 mL/kg) with a functional residual capacity (FRC) gain of 0.0 (-0.5 to 0.6) mL/kg. In 36 of 50 infants who breathed during the sustained inflation, Vti was 2.9 mL/kg (0.9-9.2 mL/kg) and Vte 3.8 mL/kg (1.0-5.9 mL/kg), whereas cumulative Vti of breaths was 16.4 mL/kg (6.8-23.3 mL/kg) and cumulative Vte of breaths was 5.8 mL/kg (1.2-16.8 mL/kg) with an FRC gain of 7.1 mL/kg (1.7-15.9 mL/kg). Heart rate and oxygen saturation did not increase immediately after the sustained inflation. A sustained inflation of 10 seconds and 25 cmH2O in preterm infants at birth was not effective unless infants breathed. Although large mask leak accounted for approximately one-third of failures, as FRC gain was only associated with breathing, we speculate that active glottic adduction may be responsible for most failures. Copyright © 2014 Elsevier Inc. All rights reserved.

Investigating the effects of laryngotracheal stenosis on upper airway aerodynamics.

PubMed

Cheng, Tracy; Carpenter, David; Cohen, Seth; Witsell, David; Frank-Ito, Dennis O

2018-04-01

Very little is known about the impact of laryngotracheal stenosis (LTS) on inspiratory airflow and resistance, especially in air hunger states. This study investigates the effect of LTS on airway resistance and volumetric flow across three different inspiratory pressures. Head-and-neck computed tomography scans of 11 subjects from 2010 to 2016 were collected. Three-dimensional reconstructions of the upper airway from the nostrils to carina, including the oral cavity, were created for one subject with a normal airway and for 10 patients with LTS. Airflow simulations were conducted using computational fluid dynamics modeling at three different inspiratory pressures (10, 25, 40 pascals [Pa]) for all subjects under two scenarios: 1) inspiration through nostrils only (MC), and 2) through both nostrils and mouth (MO). Volumetric flows in the normal subject at the three inspiratory pressures were considerably higher (MC: 11.8-26.1 L/min; MO: 17.2-36.9 L/min) compared to those in LTS (MC: 2.86-6.75 L/min; MO: 4.11-9.00 L/min). Airway resistances in the normal subject were 0.051 to 0.092 pascal seconds per milliliter (Pa.s)/mL (MC) and 0.035-0.065 Pa.s/mL (MO), which were approximately tenfold lower than those of subjects with LTS: 0.39 to 0.89 Pa.s/mL (MC) and 0.45 to 0.84 Pa.s/mL (MO). Furthermore, subjects with glottic stenosis had the greatest resistance, whereas subjects with subglottic stenosis had the greatest variability in resistance. Subjects with tracheal stenosis had the lowest resistance. This pilot study demonstrates that LTS increases resistance and decreases airflow. Mouth breathing significantly improved airflow and resistance but cannot completely compensate for the effects of stenosis. Furthermore, location of stenosis appears to modulate the effect of the stenosis on resistance differentially. NA. Laryngoscope, 128:E141-E149, 2018. © 2017 The American Laryngological, Rhinological and Otological Society, Inc.

Effect of resection depth of early glottic cancer on vocal outcome: An optimized finite element simulation

PubMed Central

Mau, Ted; Palaparthi, Anil; Riede, Tobias; Titze, Ingo R.

2015-01-01

Objectives/Hypothesis To test the hypothesis that subligamental cordectomy produces superior acoustic outcome than subepithelial cordectomy for early (T1-2) glottic cancer that requires complete removal of the superficial lamina propria but does not involve the vocal ligament. Study Design Computer simulation Methods A computational tool for vocal fold surgical planning and simulation (the National Center for Voice and Speech Phonosurgery Optimizer-Simulator) was used to evaluate the acoustic output of alternative vocal fold morphologies. Four morphologies were simulated: normal, subepithelial cordectomy, subligamental cordectomy, and transligamental cordectomy (partial ligament resection). The primary outcome measure was the range of fundamental frequency (F0) and sound pressure level (SPL). A more restricted F0-SPL range was considered less favorable because of reduced acoustic possibilities given the same range of driving subglottic pressure and identical vocal fold posturing. Results Subligamental cordectomy generated solutions covering an F0-SPL range 82% of normal for a rectangular vocal fold. In contrast, transligamental and subepithelial cordectomies produced significantly smaller F0-SPL ranges, 57% and 19% of normal, respectively. Conclusion This study illustrates the use of the Phonosurgery Optimizer-Simulator to test a specific hypothesis regarding the merits of two surgical alternatives. These simulation results provide theoretical support for vocal ligament excision with maximum muscle preservation when superficial lamina propria resection is necessary but the vocal ligament can be spared on oncological grounds. The resection of more tissue may paradoxically allow the eventual recovery of a better speaking voice, assuming glottal width is restored. Application of this conclusion to surgical practice will require confirmatory clinical data. PMID:26010240

Effect of mandibular tori on glottic exposure during simulated suspension microlaryngoscopy.

PubMed

Best, Simon R; Kobler, James B; Friedman, Aaron D; Barbu, Anca M; Zeitels, Steven M; Burns, James A

2014-03-01

Mandibular tori have been identified as a contributing factor in difficult exposure during intubation. However, no investigation has measured the effect of mandibular tori on glottic exposure during suspension microlaryngoscopy (SML). The objective of this study was to measure how the size and location of mandibular tori affect glottic exposure during simulated SML at different thyromental distances. Suspension microlaryngoscopy was modeled on an anatomically accurate skull and larynx with thyromental distances between 6 and 12 cm. Mandibular tori were simulated by protruding screws 5 to 15 mm from the lingual aspect of the mandible. The tori were positioned either 15 mm (anterior) or 25 mm (posterior) from the midline of the symphysis. The glottic exposure for the various-size tori in each location was measured by recording the displacement of the glottiscope tip relative to the most anterior exposure achievable without tori. The glottiscope angle relative to the horizontal plane was measured for each condition. Mandibular tori of more than 10 mm had a significant impact on glottic exposure. Displacement of the glottiscope tip ranged from 2 to 9 mm for anteriorly placed tori and from 7 to 29 mm for posteriorly placed tori, with larger tori causing greater displacement. Increasing the thyromental distance increased the posterior glottiscope tip displacement regardless of torus size or location. The glottiscope angle increased with larger tori (12º to 28º), but this angle did not change with increasing thyromental distance. Larger size and more-posterior location of mandibular tori more significantly reduce glottic exposure during SML. The inner table of the mandible is the most relevant anatomic constraint on glottic exposure, which varies with the presence or absence of mandibular tori independent of thyromental distance.

Respiratory Sinus Arrhythmia: A Potential Indicator of Cholinergic Toxicosis in Rhesus Monkeys (Macaca mulatta)

DTIC Science & Technology

1990-01-01

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Management of Posterior Glottic Stenosis using the Combined Glottic Reconstruction Procedure.

PubMed

Nouraei, S A R; Dorman, E B; Vokes, D E

2018-05-29

Laryngotracheal stenosis secondary to Bilateral Vocal Fold Mobility Impairment (BVFMI) is a challenging condition to treat. The glottic aperture accounts for 25% of the respiratory resistance 1 and BVFMI prevents its breath-by-breath regulation, causing severe airway compromise. Moreover, since the larynx is also the organ of phonation and its reflexive closure during swallowing is the principal airway protective mechanism, improving airway may worsen dysphonia, dysphagia, and aspiration. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

A Novel Artificial Intelligence System for Endotracheal Intubation.

PubMed

Carlson, Jestin N; Das, Samarjit; De la Torre, Fernando; Frisch, Adam; Guyette, Francis X; Hodgins, Jessica K; Yealy, Donald M

2016-01-01

Adequate visualization of the glottic opening is a key factor to successful endotracheal intubation (ETI); however, few objective tools exist to help guide providers' ETI attempts toward the glottic opening in real-time. Machine learning/artificial intelligence has helped to automate the detection of other visual structures but its utility with ETI is unknown. We sought to test the accuracy of various computer algorithms in identifying the glottic opening, creating a tool that could aid successful intubation. We collected a convenience sample of providers who each performed ETI 10 times on a mannequin using a video laryngoscope (C-MAC, Karl Storz Corp, Tuttlingen, Germany). We recorded each attempt and reviewed one-second time intervals for the presence or absence of the glottic opening. Four different machine learning/artificial intelligence algorithms analyzed each attempt and time point: k-nearest neighbor (KNN), support vector machine (SVM), decision trees, and neural networks (NN). We used half of the videos to train the algorithms and the second half to test the accuracy, sensitivity, and specificity of each algorithm. We enrolled seven providers, three Emergency Medicine attendings, and four paramedic students. From the 70 total recorded laryngoscopic video attempts, we created 2,465 time intervals. The algorithms had the following sensitivity and specificity for detecting the glottic opening: KNN (70%, 90%), SVM (70%, 90%), decision trees (68%, 80%), and NN (72%, 78%). Initial efforts at computer algorithms using artificial intelligence are able to identify the glottic opening with over 80% accuracy. With further refinements, video laryngoscopy has the potential to provide real-time, direction feedback to the provider to help guide successful ETI.

Companies Participating in the Department of Defense Subcontracting Program. First Three Quarters Fiscal Year 1991

DTIC Science & Technology

1991-01-01

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M-X Environmental Technical Report. Socioeconomic Impact Estimates for Millard County, Utah. Detailed Tables.

DTIC Science & Technology

1980-12-22

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The AFGL Four Color Infrared Sky Survey: Catalog of Observations at 4. 2, 11.0, 19.8 and 27.4 micrometers

DTIC Science & Technology

1976-09-17

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Deployment Area Selection and Land Withdrawal/Acquisition. M-X/MPS (M-X/Multiple Protective Shelter) Environmental Technical Report. Regional Economic Analysis.

DTIC Science & Technology

1981-10-02

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Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, Fiscal Year 1987. Part 7. Fairlane Gear, Incorporated-General Fiberglass Fabricators.

DTIC Science & Technology

1987-01-01

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Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, Fiscal Year 1985. Part 11 (International Computer Corp - Kloze N S Inc).

DTIC Science & Technology

1985-01-01

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DTIC Science & Technology

1991-01-01

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Can IMRT or Brachytherapy Reduce Dysphagia Associated With Chemoradiotherapy of Head and Neck Cancer? The Michigan and Rotterdam Experiences

DOE Office of Scientific and Technical Information (OSTI.GOV)

Eisbruch, Avraham; Levendag, Peter C.; Feng, Felix Y.

Purpose: Dysphagia is a major late complication of intensive chemoradiotherapy of head and neck cancer. The initial clinical results of intensity-modulated radiotherapy (IMRT), or brachytherapy, planned specifically to reduce dysphagia are presented. Patients and Methods: Previous research at Michigan University has suggested that the pharyngeal constrictors and glottic and supraglottic larynx are likely structures whose damage by chemo-RT causes dysphagia and aspiration. In a prospective Michigan trial, 36 patients with oropharyngeal (n = 31) or nasopharyngeal (n = 5) cancer underwent chemo-IMRT. IMRT cost functions included sparing noninvolved pharyngeal constrictors and the glottic and supraglottic larynx. After a review ofmore » published studies, the retropharyngeal nodes at risk were defined as the lateral, but not the medial, retropharyngeal nodes, which facilitated sparing of the swallowing structures. In Rotterdam, 77 patients with oropharyngeal cancer were treated with IMRT, three dimensional RT, or conventional RT; also one-half received brachytherapy. The dysphagia endpoints included videofluoroscopy and observer-assessed scores at Michigan and patient-reported quality-of-life instruments in both studies. Results: In both studies, the doses to the upper and middle constrictors correlated highly with the dysphagia endpoints. In addition, doses to the glottic and supraglottic larynx were significant in the Michigan series. In the Rotterdam series, brachytherapy (which reduced the doses to the swallowing structures) was the only significant factor on multivariate analysis. Conclusion: The dose-response relationships for the swallowing structures found in these studies suggest that reducing their doses, using either IMRT aimed at their sparing, or brachytherapy, might achieve clinical gains in dysphagia.« less

Candidate Dosimetric Predictors of Long-Term Swallowing Dysfunction After Oropharyngeal Intensity-Modulated Radiotherapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Schwartz, David L., E-mail: docdls@mdanderson.or; Department of Experimental Diagnostic Imaging, University of Texas M. D. Anderson Cancer Center, Houston, TX; Hutcheson, Katherine

2010-12-01

Purpose: To investigate long-term swallowing function in oropharyngeal cancer patients treated with intensity-modulated radiotherapy (IMRT), and to identify novel dose-limiting criteria predictive for dysphagia. Methods and Materials: Thirty-one patients with Stage IV oropharyngeal squamous carcinoma enrolled on a Phase II trial were prospectively evaluated by modified barium swallow studies at baseline, and 6, 12, and 24 months post-IMRT treatment. Candidate dysphagia-associated organs at risk were retrospectively contoured into original treatment plans. Twenty-one (68%) cases were base of tongue and 10 (32%) were tonsil. Stage distribution was T1 (12 patients), T2 (10), T3 (4), T4 (2), and TX (3), and N2more » (24), N3 (5), and NX (2). Median age was 52.8 years (range, 42-78 years). Thirteen patients (42%) received concurrent chemotherapy during IMRT. Thirteen (42%) were former smokers. Mean dose to glottic larynx for the cohort was limited to 18 Gy (range, 6-39 Gy) by matching IMRT to conventional low-neck fields. Results: Dose-volume constraints (V30 < 65% and V35 < 35% for anterior oral cavity and V55 < 80% and V65 < 30% for high superior pharyngeal constrictors) predictive for objective swallowing dysfunction were identified by univariate and multivariate analyses. Aspiration and feeding tube dependence were observed in only 1 patient at 24 months. Conclusions: In the context of glottic laryngeal shielding, we describe candidate oral cavity and superior pharyngeal constrictor organs at risk and dose-volume constraints associated with preserved long-term swallowing function; these constraints are currently undergoing prospective validation. Strict protection of the glottic larynx via beam-split IMRT techniques promises to make chronic aspiration an uncommon outcome.« less

Clinical and dosimetric implications of intensity-modulated radiotherapy for early-stage glottic carcinoma

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ward, Matthew Christopher, E-mail: wardm3@ccf.org; Pham, Yvonne D.; Kotecha, Rupesh

2016-04-01

Conventional parallel-opposed radiotherapy (PORT) is the established standard technique for early-stage glottic carcinoma. However, case reports have reported the utility of intensity-modulated radiotherapy (IMRT) and volumetric-modulated arc therapy (VMAT) with or without image guidance (image-guided radiotherapy, IGRT) in select patients. The proposed advantages of IMRT/VMAT include sparing of the carotid artery, thyroid gland, and the remaining functional larynx, although these benefits remain unclear. The following case study presents a patient with multiple vascular comorbidities treated with VMAT for early-stage glottic carcinoma. A detailed explanation of the corresponding treatment details, dose-volume histogram (DVH) analysis, and a review of the relevant literaturemore » are provided. Conventional PORT remains the standard of care for early-stage glottic carcinoma. IMRT or VMAT may be beneficial for select patients, although great care is necessary to avoid a geographical miss. Clinical data supporting the benefit of CRT are lacking. Therefore, these techniques should be used with caution and only in selected patients.« less

Peer Ratings: Scoring Strategy Development and Reliability Demonstration on Air Force Basic Trainees

DTIC Science & Technology

1980-09-01

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Annual Report 1981. Part II.

DTIC Science & Technology

1982-01-01

Arkansas LRD AR 67 162.0 - 110 0 29 LD 1 Arkansas LRD AR 67 142.0 - 2 0 29 * Section 7 Flood Control Projects "Ilncludes dead storage. oonservation...m 0 ONO 0)00) ɜ Z -4N N Orin) 0.0 V ) 4, 0 aV) 0)-4 V m0 V 4e40 4P -0 1 000 m)0 0) 0 - 0 (. %V0) N 4-0 00 -0- 00 4 4 00 -~0 o0 NIr- N u -40 C) -N...4’ ) M0. 4r M V 000 I Lb J 0~ (14 N 0 -01 CIl U. U*C.V .X~ N N N %N 1 r N N N ui U)() ( 4P 0 0Mu D,0 10 V 2 W 0)0) NW- V0 l 21 N)4 N00. .0 W 0 10 NON

All Prime Contract Awards by State or Country, Place, and Contractor, Fiscal Year 1985. Part 9 (Aberdeen, Maryland - Woodbine, Maryland).

DTIC Science & Technology

1985-01-01

W ’I-N004I NZ EOZ MUOIO N mU-4 mU. E- b MWoo M-O C ICOI N O4-0b O N40 N moNjO w-I-4-IOOO 000 0-I 0-I M-I mo m, (’I .44 c)4uu(O N - 00000 (I-CL) ON...4 -4 Of4 N-4-4.4-4-4-4 CM c-4 CM ~- I b In N. in Nv in- -( -4 N I Nl LN൴nNN NN I N 4 I IN In C, .’ I’- . -4 4 N4 N , - -4 -4 N NNNNN N4 N4- N0 . 4...00 0M ON4 0) 0- 0 0 0 0 04 IU :-41 N o N v - (4 N N ) N N N N NK r IN N4 00l~ b 04 C. 0i N ig) Ne le -00 Wn Gob O V 𔃺 0I0 - 4 04 M4 U) ( 0 4M Go( 00

Building Maintenance and Repair Data for Life-Cycle Cost Analyses: Heating, Ventilating, and Air Conditioning (HVAC) Systems

DTIC Science & Technology

1991-05-01

DC area labor and equipment rates were applied to this data to produce the tota!s shown in the column so titled. This column is given to pro , ide...00 m 30 c 000 CD OMOO CC m *~ O mO co 0 c~ m n 0mc c. co 0 m00mm o mo cU m m Dm M .N.Q mcn, In N m g -t C𔄃’ m’ g. 0 .0 .O 0 c gmO mOo gg 2 0 ! NOO O...N -. .. . 0 0 1 .00M000 .0 0 .o..0.. .0 ~0 90 0 00 3 0 ~ ~ .4 M~ c,0fOfllfOflOol"f~l~n u’gmlig iu olvn bO 00m Go0m mfl M"n - PRO .% .. R. M R 0’~~e

Resistance and Stock Propulsion on the High Speed Sealift (HSS) Hybrid Contra-Rotating Shaft-Pod (HCRSP) Concept, Model 5653-3A

DTIC Science & Technology

2008-09-01

8217 I l ALW N- N OD0 OH (N IV’ W 00 H- -W’ 0) (Nq Ht DC1 C’w H HH HrHir-1r-1C4(N N m 0H 0 E rr.. .1 0 29H0UH WP 4t or -u HH H HN wo)w i o I CW0W M IDID01...l C4 H NA a) N’ N) ~ N C14 N m m U m (0 a) m H (N U M m v IV -IN . . . . . . $-Na A F- " (N -l(04" 04 -4 -4" Ht -4 F- e~N rlN m H 0 CmN’rCr m ) m mmm...H O H-4 LALANOLAHCO)a)C"la)iL. . .N.a. .OHA.. . H.N.N.O.N.l. . 0HH H H H kel( N O L A 0 M m.) L ( 0 1 WmmN r 1 4 4w o oW W 6m o ( o,WmL A6L A 6L A L

Projections of Demand for Waterborne Transportation, Ohio River Basin, 1980, 1990, 2000, 2020, 2040. Volume 11. Group IX. Feed and Food Products, NEC.

DTIC Science & Technology

1980-12-01

9HIORIVER BASIN 198p, 199, N40, 2029. Prepared for U.S. ARMY CORPS OF ENGINEERS OHIO RIVER DIVISO, HUNTINGTON DISTRICT Contract N DAcW69:78136 by Robert...m c w a 0 %0 -. r, 0 *.. m 0 m 0 0 MI 0% 0 %Dr- 00 HN 0 V4 1 0 I I a, ID %D m .0 4 o 𔃺w0 -Wl N -W 0 H M 0 40 W4 0 N 0 10 0 : C!o 9 11 Ni C!0.-I 0 9...9 ox 0) ON V; .1 C4 .11 at w -I 0 o 4J 0n In ~ Hn In 0CO0 . . 0 4 0 40 0 i 0 0 0D -I 4 14 N N 0’ m 0 40r- N .,I U, mZ 4 0 0 004 H N0 000 CW 0 00 O a

Environmental Variability of the Jordan Basin, Gulf of Maine, August 1982, NRL (Naval Research Laboratory) Cruise 712-82.

DTIC Science & Technology

1983-11-01

CaL E 0-0 I ~ C 2 ~ O SOIC 2 q W . - -NN0N0 - N M N N WW M M 0 00-r-- N MV a- 0 -0WII- O 04 Vf 0 M M~f 0 0 r, 0IfN MfM0U0 v 000 0 0 ,N 0 .JoW w...NUMBER 7. AUTHOR(e) I. CONTRACT OR GRANT NUMBER(a) Benjamin A. Watrous, Jr. Roger J. VanWyckhouse Joseph V. Soileau 9. PERFORMING ORGANIZATION NAME AND

Differences in health related quality of life in the randomised ARTSCAN study; accelerated vs. conventional radiotherapy for head and neck cancer. A five year follow up.

PubMed

Nyqvist, Johanna; Fransson, Per; Laurell, Göran; Hammerlid, Eva; Kjellén, Elisabeth; Franzén, Lars; Söderström, Karin; Wickart-Johansson, Gun; Friesland, Signe; Sjödin, Helena; Brun, Eva; Ask, Anders; Nilsson, Per; Ekberg, Lars; Björk-Eriksson, Thomas; Nyman, Jan; Lödén, Britta; Lewin, Freddi; Reizenstein, Johan; Lundin, Erik; Zackrisson, Björn

2016-02-01

Health related quality of life (HRQoL) was assessed in the randomised, prospective ARTSCAN study comparing conventional radiotherapy (CF) with accelerated radiotherapy (AF) for head and neck cancer. 750 patients with squamous cell carcinoma (of any grade and stage) in the oral cavity, oro-, or hypopharynx or larynx (except T1-2, N0 glottic carcinoma) without distant metastases were randomised to either conventional fractionation (2 Gy/day, 5 days/week in 49 days, total dose 68 Gy) or accelerated fractionation (1.1+2.0 Gy/day, 5 days/week in 35 days, total dose 68 Gy). HRQoL was assessed with EORTC QLQ-C30, QLQ-H&N35 and HADS at baseline, at end of radiotherapy (eRT) and at 3 and 6 months and 1, 2 and 5 years after start of treatment. The AF group reported HRQoL was significantly lower at eRT and at 3 months for most symptoms, scales and functions. Few significant differences were noted between the groups at 6 months and 5 years. Scores related to functional oral intake never reached baseline. In comparison to CF, AF has a stronger adverse effect on HRQoL in the acute phase. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

All Prime Contract Awards by State or Country, Place, and Contractor. Part 5 (Vineburg, California-Wyoming, Delaware)

DTIC Science & Technology

1990-01-01

4 a:: wi :t mo 400 N erntiofl0o~Nco cf),4In m in N It N O0) I I C) q N! 1 )-11uIto00 N qt 1- 0 0 0) 15.1 C: c 40 N Me o- -4 CV) 00 I M100 00 Nf 04 NCV ...00.-4 1 61 4 t wt it 4 q**- 0 nCV ) ..I)0)00 I- M m0Y) m0I00m0MCV00m000Y00mIn00Y00000m000000000) IL.4 (-4 NNINNNNNNNNN 00 00000C004- q- .. 4-4- 4 - 44...4N N ൰CV N N 4 .40 8&.NC40000 NCV )(’ am 000 N> in 24 Z.C’%> a EI*0 woo E E E E E 9 III - I Coc 1140 -i at 0 0 -mN 06* 00 Is40 10 V V 1L a. UI *6

Circular Polarization Scattering Coefficients for the Bistatic Scattering of Electromagnetic Waves from Perfectly Conducting Spheres

DTIC Science & Technology

1976-07-01

mO’D N m N0 M " 102M ~0’ MiO-i rrN, M O 10 ý0 1m1o O As~fO~ Ni,~ in.0M’ 0 MN0 N N~ N CM~o𔃺a’~ *4,0m in rt - I W M 𔃺 "Am ,-o0oa 0 -0 1 M0 "’ .N o * 0...0.0* *4 * . 04. 0 i/0 l/n il/il/~ 03 04 "a- 00000 00000 00000 00000 00000 00000 00000 00000 00000 ,,;1-I ýv r r r r r r r - rt -r r r r r r r rr1a~i,- rrr...8217.:,t NN M a a1SI U3l04 a 44f a noU𔃽ag! a v4 No1’ MMMNN’ 0 1 1NN W~ rr rt Drr. o.- .- o 0 00 0 0000 vo-NlO~e m1o.0 lowt!%Dt-frMr.(D. r I NrO all-4* C

Official Guard and Reserve Manpower Strengths and Statistics: FY 1989 Summary

DTIC Science & Technology

1989-01-01

S0- 5.8 co It0. 0 m a* t7 N 𔃾 in o𔃾 t N o - n-K, 0 mI- IZ 0 N m i an N 0o cm a, . KZK UK 14i N~’ 47 𔃾 N 0’ 0 D- 0 00a, c KlS K K I NNN 7n 𔃾 𔃾 No...W C, 00C0F)a*P m 00 on 0..0.....P00Mlso0 do w .P- 638%1 P 1 KZK ~ ~ P)goMK II- .8 4N i 40. 8 4 I.5M!.4M0󈧣U . * . P) woo- 3. 30 K 30A- N C4 in4C i K

All Prime Contract Awards by State or Country, Place and Contractor. Part 6. (Alachua, Florida-Winder, Georgia)

DTIC Science & Technology

1989-01-01

0-4 N :: fIilNN N N N NNN N N N- N N N NQ’ C.-1-4 48 2 2 2 2 z z2 22 M 2 2 2 Zof 0-40 It 104 0 44 4 0 N 4L 0) M 8 It 000 filico!I 00 !d x zaW < K 011...1)2-4 -4 < tuN V)M-4 fl.11) ..- 42 1, (0N MM tcOC’)U)00-4mU)2-0 0) 00 0) i1 inC-U)N0) .4 It I N <Cj ifm-4U)’Lnw)(04) ON -44 4t00 0-4-4 -4-4 - 0 0...8217N N 4U-4.-4-4 tUN (UO) M 4-4.--4I-4-4 -4 dUO 0101 UN0I 0-4N00 11.0 0 -4 00000 --4 0 -hC A 0 _4(. 4 (A 000/00(000000() u ( , -0 ., r-at I M -4 4 C f

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, FY 85. Part 13 (Mabco Prefabricated Bldg -Middletown Leather Co In).

DTIC Science & Technology

1985-01-01

04 C4 I4 C4I CNN NNN M.4f * N N N -4 -I .4 II.4NN *>-I w- C .40 C t In I, 0 I 1IC w040000oN 0 C4 . I CL 0. 0CZ in WI I )M nMI nIinn 00 CO(-ic.) I enC ...m I1 cNNL N ENC ’ 00 N N) N4 0(n MCI I C) 4 I -000r4 0 *.-0.- N~0 COJ cm mOi cl j C4 CMcj I ~ C)N NN 4~ Il N-.I-0I- 54-0 4 IU-4 1.I 4.I (I 4N - I ca c...40o 3X0 EN ENC , 3N 0 o-4 I-- EN" 0-4 1-400 MI 4 MO m)-I No 0 4- 0) (0 40 co In (o aU’Do Ml) 0 0 00 -4 -4 0 0 0 0 0 0 0 0 440)t M4 I n In In Ln -f 4 U

Far-Field Acoustic Data for the Texas ASE, Inc. Hush-House. Supplement.

DTIC Science & Technology

1982-04-01

wJ t* = -W 0 0.0 cu x. C. m 4!T a. 1 1I IA r2 m0 r t S ’ (A WA w. ". .9 wL * . ac ti 40 I m. aL O 0.14 .) . w -4 En 1 4~~~ 0n an ~ .~( LL (AU. a.3W 0...I I I A (P8%48~t N0I f IS I I coI N m M V4 MO N MM M 6N I 1 0 1 0 .* . .. . . I N 1) %0JO e 10kainM rt w tSY (n0 En " I N W M V 0 4tF . I4 Ilg~g w r 1...A m~ommm at a-at t- * * I m* m a 5 1. tS go .W m 0A400. 0* eN d W) I 4 z 5 -?ZX5OGs II*PII. 1 0 5 OR I ’. Of . I of 50 I * V)A9Ct. 1;4 44944a so ~ ~ 1

Anthropometric Survey of the Imperial Iranian Armed Forces. Volume 2. Statistical Data

DTIC Science & Technology

1971-03-01

nI JIni D D 0c41 1. 4n Lk MN ~ LAMO NOO’O-0’r4 -4 ’t 4 ~ ý N-*I4Lr- -44 o.L .4 - o N"-4 0 4lA in0. coN -4. -4 . 41 Go N- -4 0 - 0 0LINA .4 4 P.4LA...m -4 0r o40 r4 C4 N 0 - -n 0 ’-40 t . . 41 .-. 4, d O - .0tiI-P .- A -n 0 N m a,4( 0 gao Mr .’m00 < OD r- mo N~ m,- (314- 0 0.0C l i O ~ j - 000 04 m

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 1. (102 Construction, Inc.-American National Management)

DTIC Science & Technology

1989-01-01

KTN M4 I- M MN 0 .1-4 4 r-ON- a N r-r- 00 ’- 400 N- cma 0C00 N PN- (0 *mm" 44)- I nI 40 4 , , , 1 -4 w - 1-4 m N -4 N~ Moo0 U, 0)IIO0 I ( -4 N C1) -40...0 -4 If 40M( II, 0. 0t 4 M 00m 0.-40-4 a- 0 C-4"ONNN00 - 400 4T Nl oil I 05( 1 C, 0 -. 1i 0D -4C >C -40 -4-4--4 -4 -4- 40 -40C>-J! 0-1 0 0>~I 51 I...0 40 If 0 10 M I I 0> InaO< < 4n 444U U’)nU"UU oU 40 CON ( D0a C>Q 0- r0 ?- NUn 11 < CO-4 II CI >0 0 - - 400 - "-4 - 4-0 4 0 >-0) O)N t I 41110 -4 If

All Prime Contract Awards by State or Country, Place and Contractor. Part 7. (Aiea, Hawaii-Zion, Illinois)

DTIC Science & Technology

1989-01-01

000 oao 0000 ’ 0 10 1 a I 0> I 01300011N 1 in 21 14-4 4140 (D 0 0 N1 -4 U) C1) (n N W I U)rK>U 11 0-4 -44-4-4 q-4 0-4-4-4 0.4 -4-4 0.-I 44O N N N in...4 if4-00 )r )(O c 00 -4 00 NO 0M 04 ,P-4 (4M (07) (0 r- on 1,-4 144(I0M4 if4-4 ."(-10 t VI = 141 Mx 00 Ni 20 4441 00 M 1 V 00 N 00 < 4140 ) I(0-4l if 4...00 4 44 It -0440 M 0 100 0 100 I0 (10 000000 140000 4140 MOO w- SI - x M fit0 mI M0 -40 1-400 -4 I -0 .n Z-400 0 0 -40 󈧬 045 I4’ (04 II .-4N 0 c

Vibration and Temperature Survey Production AH-1G Helicopter

DTIC Science & Technology

1974-03-01

0: C - r- 00 ’ % 0 0(l be m0 a%0 i 4 N ,4 en - -.t m0 0 A V4 -n en w- .- C14N N cn M o 0n %o 0o IA 𔃺’ n co r’- t,- % m A 00o % a% en 0 w % C4 0 0; I...c4 A’ 4 O 󈧅 C4 9 WA . 04 (1--N N Y4 (n~ N N en 4 4 4 4 C C 400C N. -4 -T %D - w4 0 co 0 M 0 r- 0 NN fn r, OD N ONOD0-4 n % C6 LA r 00 41 0 C6I 11 A...iight (100) 204 and 205 Le,, el Flight (101) 206 and 207 Climb (102) 208 and 209 Descent (103) 210 and 211 Takeoff (104) 212 and 213 Landing (105) 214 and

Alpha List of Prime Contract Awards. Oct 91 - Sep 92. FY 92 (Avonix Corp - Branscome Henry S Inc)

DTIC Science & Technology

1993-01-01

0) 0)0) 0) 0) 0) M M M M M M M M M M MM0) "-4 "f-4 1 mo0m If 0MC’)09- --4 0 aP-. 0)-4 M041-4 0-4 0 4q0 -0InC" JInI In49--.M0t) w 0 w0w wC> 0NI mumNO I...4CI 0)0 4’l 40 ’a C.C) 0 0)-" GAO 1LO -3 ~C(n -4 0 EOc-N -i N-4 E O cl) W4 0)0r 45.-411 n mIMP-It00 c4 lr 0) 041) 0w(om4’ W-4 0 0 4(0o-4N 4’ ) 04’) 0...MOA 4a L-0 Co 00 4 0 CIC -4 0 Do𔃺_~ai - 1 0 00 C400 -44.~40 to0 in W NI 4 W 0C),04 t 44 -to nlm 0))00 ) GAO ) 140 4m 0)0)0) -i0) -40)0)0)0)0) -i0

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, Fiscal Year 1987. Part 5. Conti Corporation-Donley-Bundy & Associates.

DTIC Science & Technology

1987-01-01

8217 I ( 0 0 . C . -. - (0 (0 c.-.C.C. U- C.) 0 *Y 0 040 Ni N0 .0 0000 0 t- 0 0 (0(0(000 (1 I C.) In 00 Go0 (n m LflOo -4-4 W0 en 0 0 c c r’)) NN CV C4 4...8217-. 0 00 60 00 z~- 00 m - i n 6 -400 c -4 -4 -4-4-4-4 ɜ -4c 04 N-NN-NI N-N-N-N- I6 oo I UOO Ow 0 A WCUA0Zc A r c L < W WC AW0( 60 6 N EN 0 00u0 60 < : 0...w0 = 4 - I 7 - = v N u>N Wn (O WA M M 40 WM< 0of 0ci 0 0 0)N U00 0L) 4Y 0 0 knn - -so w0I M < 6 0-14 -1N ON N O 4NNN< 10~4 ɘɜ EN " N NN N 00NNN0

Performance and Loads Data from a Wind Tunnel Test of a Full-Scale Rotor with Four Blade Tip Planforms

DTIC Science & Technology

1980-09-01

a.c ~~cceccc.~~CCo COeCO @Coc Cacao ace cc* Ow. a 6 -**40 r’M18 - 4 5* 1~ *4 I VII I I cccccccco CeCCCCCC cccoo cacao acccC acC eccc t4 C m 9- VFAFA...0 Q- 0W%0 0 *0 00N’ 0M 00M 0 00 0 00 a. De (A m~) 0010 moo 0 t- 0 N fl,0 tt- 0O t0%0 N-4 co 0 N cc Z 0 -. 4b . N-4 0 F400 4 0 0 0 00 00 a 40 040 .0...C3M C 0 0.-e 00-~ 0 0 LL V4% % De ON WON r’- eN Ml.ý4N ’tGo N Nf Ln N0 0.00 oA𔃺 MNO 4NO ONO x Wr a t.-0 0o a)o ~0 1,- 0 000 000 t-UQ tj n6os f- o 0

Interlevel Correlations of Temperature and Density, Surface to 60 KM

DTIC Science & Technology

1980-05-14

N 4 W ON . .4 4. 40 N 2NW N N 0.04’ 44 0N4 I N no In CTnO 0y a. N N~ Wq I N 4 M ANA. 4N 4 4 N *f~ 0 I No0 N N won N N I 1 00A N 2 U 0 N In W 04* ON m...40. d 5- 14𔃺 ’ 4’C 110*0 44.4102 . itm 4m, 0 0 4wID oU MI .0 a’n ’. UI tao M u . o0’ Nj It%U’ .4n N 0 1. ow 4LJ N.41 .4 a MMM _j 0 D4 Z P2 0 w0 w

Official Guard and Reserve Manpower Strengths and Statistics. FY 1988.

DTIC Science & Technology

1987-12-01

i- f) 3 0) . 4 m r, 303 ri o0- . ’A It0Nr.0 0 m &0 m. omO4r w or-W’F4 04.nr4 m0 0.Mr- - .4 r,M. ., mru -4.a r - * DLn n 0A m-.0 IT 0- 0 r, T N. 0 0m. 0...sonhhhhhhhhhhhl 1111.25 111114 6~IM~ M’CROCo’Y ILSOLUTION TESI CHAi NATIONAl SURL’AU Jf ANUAPDS, 164 % % AI %~ -i .oo o 0 - .0 N. ..a iN -S r- O 0 4

Management of complex glottic stenosis in children with recurrent respiratory papillomatosis.

PubMed

Siegel, Bianca; Smith, Lee P

2013-10-01

To describe our management of complex glottic stenosis in tracheotomy dependent children with severe recurrent respiratory papillomatosis. Retrospective chart review at a tertiary care children's hospital. Three children with complex glottic stenosis secondary to severe recurrent respiratory papillomatosis were treated at our institution since 2011. Two patients had complete stenosis, and the third had near-complete stenosis. Two patients were managed using balloon dilation alone, and the third also underwent laryngotracheal reconstruction with posterior costal cartilage grafting. Two patients have been successfully decannulated and the third has been tolerating continuous tracheotomy capping for greater than twelve months. All three patients underwent aggressive debridement of papillomatosis and balloon dilation every 4-6 weeks until their burden of disease was controlled. In two patients, the glottic airway was patent, and the third continued to have complete restenosis between procedures and required laryngotracheoplasty with multiple post-operative dilation procedures to establish an adequate glottic airway. Severe laryngeal stenosis is a well-described complication of recurrent respiratory papillomatosis, but its management is not well-defined. Aggressive management of papillomatosis with frequent debridement is critical in successfully managing laryngeal stenosis. Balloon dilation alone may be surprisingly effective in these patients, and laryngotracheoplasty can be used as an adjunct procedure in those patients who fail balloon dilation. Given the quality of life issues and concerns regarding distal spread of disease with tracheotomies in these patients, we feel that aggressive management and early decannulation is in the patient's best interest. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Bipedicled strap muscle transposition for vocal fold deficit after laser cordectomy in early glottic cancer patients.

PubMed

Su, Chih-Ying; Chuang, Hui-Ching; Tsai, Shang-Shyue; Chiu, Jeng-Fen

2005-03-01

In treating early glottic carcinomas, the outcomes of endoscopic laser cordectomy have been proven to be valuable in local control, survival, and vocal function preservation. In some extended cases, however, laser cordectomy may leave patients with poor vocal function because of vocal fold deficit. This work assesses the vocal outcome of medialization laryngoplasty with bipedicled strap muscle transposition for vocal fold deficit resulting from laser cordectomy in early glottic cancer patients. A prospective clinical series. Thirteen early glottic cancer patients who had vocal fold deficit caused by previous laser cordectomy underwent medialization laryngoplasty with bipedicled strap muscle transposition. The thyroid lamina on the cordectomy side was paramedially separated. The inner perichondrium was circumspectly raised from the overlying thyroid cartilage. After separating the thyrohyoid and cricothyroid membranes, the lamina was retracted laterally. A bipedicled strap muscle flap was then transposed into the area between the lamina and the paraglottic soft tissue. The thyroid cartilages were carefully sutured back in position. All patients received pre- and postoperative voice assessments comprising laryngostroboscopy and vocal function studies. Vocal enhancement was present in 92% (12/13) of patients after medialization laryngoplasty with strap muscle transposition. The glottal closure and maximal phonation time were noticeably improved by surgery. No dyspnea or other significant complications were observed in any patients. The outcomes show that bipedicled strap muscle transposition is a prosthesis-free, safe, and valuable laryngoplastic technique for correcting glottal incompetence caused by endoscopic laser cordectomy in early glottic cancer patients.

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 4 (Better Insulation Services - CSP Inc)

DTIC Science & Technology

1990-01-01

0 )> 0 ) N o NOa (aP 403 5 4101, .M-I i ) W) Lu.J %" w0) WM0 Ili00 wa M 0 woo) wm w ) U. 00 CC L-00 *ILA M(-4 M6(D( (0In (-4 ( 0 ( (04 M- In (0t 0 ( 0 ...40000000000 00 I(-4N iI , 0 iti -wC) N -4 r- r- t>- NZM ɜ -01 ( 0 I n n( CO l 0 In 0 M U 5 ( 0 -40 F (*2 11 -422* nz w2Z* -422.z -%c 222222222222zz IO 0 ...P010 Itu 1-. ao 00 0 *- 044 -4n ( 0 (0w0( 0 ( 0 ( 0 ( 0 (00( 0 (

Prime Contract Awards by State or Country, Place and Contractor. Part 7 (Lake Park, Georgia - New Haven, Indiana), FY1991

DTIC Science & Technology

1991-01-01

4 N3- 4 U n t -C 1.U.00 00L00 * 0Goa oCI LAdo .C000 4 G-4 00 -4 WW4 L.4000 0L o 30 U in0(Y) U, 0 -4-4-4-4-4.4CF 0 0M - 00 0 M f 044- (Dcu4 01 UI (U0...m rfin In in tri j3li I M) 1 16-1-4 N-4 - 00 enC 0 -4- m-N N N4-4- 1 - 4- - 4- -4 --4-4 4- dI 6) I I Im~ 1 4 1I -N 0 -4 CL 4 - 4 -0 ccw r-t- 1" w 0 m...4 -4NN4N4C UN4 uD U-1 -4- 4-IN .4- 4 O -4 1 0 K 1, () 4 0 C. l u ) i N4 0 -in 000 = - =D mN 31 Pi-.- -4 ENC - 0D K 0. 1 04t Km -0 1- .1 -0Cl 1- 0 1-0

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, FY 88. Part 3. (Bakers Constr. Co., Inc.-Burns Lumber Co., Inc.)

DTIC Science & Technology

1988-01-01

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General Aviation Activity and Avionics Survey

DTIC Science & Technology

1988-11-01

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Pre-emptive glottic enlargement before laryngotracheal surgery in patients at high risk for postoperative bilateral vocal fold paralysis.

PubMed

Schweiger, Thomas; Hoetzenecker, Konrad; Roesner, Imme; Schneider-Stickler, Berit; Denk-Linnert, Doris-Maria; Klepetko, Walter

2018-02-01

Bilateral vocal fold paralysis (VFP) is a severe complication after laryngotracheal (LT) surgery. The reduced glottic opening leads to significant respiratory distress immediately after the operation and requires the placement of a tracheostomy in most cases. Patients with a pre-existing unilateral VFP or expected recurrent nerve resection are at the highest risk for glottic failure. These patients might benefit from a pre-emptive glottic enlargement before LT surgery. We performed a retrospective review of patients who received a pre-emptive glottis enlargement before LT surgery at the Medical University of Vienna from October 2011 to December 2016. Peri- and postoperative outcomes of this strategy were analysed. Six patients underwent preparatory glottic enlargement prior to LT resection. Four patients had recurrent thyroid cancer, and 1 patient had thymic cancer invading the cervical airway. The remaining patient had a complex benign glotto/subglottic stricture complicated by a pre-existing bilateral VFP. All patients received oblique cricotracheal resections extending into the larynx [resection length 39 ± 7 mm (mean ± SD)]. Extubation within 24 h after surgery was achieved in 5 of 6 cases, although all patients had postoperative unilateral (n = 5) or bilateral (n = 1) VFP as anticipated. In 5 of the 6 patients, oral intake could be started immediately after the operation. The remaining patient regained full swallowing function after intensive swallowing rehabilitation. Postoperative voice quality was subjectively perceived as satisfactory by all patients. Pre-emptive glottic enlargement is a valuable treatment strategy in patients at highest risk for postoperative bilateral VFP. It facilitates immediate postoperative extubation, despite at least unilateral VFP and extensive LT surgical procedures. © The Author(s) 2018. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, Fiscal Year 1985. Part 9 (Good-All Electric - Hi Grade Food Products).

DTIC Science & Technology

1985-01-01

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Dollar Summary of Prime Contract Awards by Contractor, State or Country, and Place, FY 85. Part 2 (D & A Construction - H & H Service Corpor).

DTIC Science & Technology

1985-01-01

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Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, Fiscal Year 1987. Part 2. American Steel & Wldg. Company-Becker Sand & Gravel Company, Incorporated.

DTIC Science & Technology

1987-01-01

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Prime Contractors with Awards Over $25,000 by Name, Location, and Contract Number. Fiscal Year 1993. (Lytron Incorporated-Quest Integrated). Part 4

DTIC Science & Technology

1994-03-01

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Alpha List of Prime Contract Awards. Oct 92-Sep 93. FY93. (Claude Ralph - Day Francis O Co. Inc.)

DTIC Science & Technology

1994-03-01

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Dollar Summary of Federal Supply Classification and Service Category by Company. FY 87. Part 3. Q504-R505.

DTIC Science & Technology

1987-01-01

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Projects in Computer Aided Climatology.

DTIC Science & Technology

1981-07-01

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Alpha List of Prime Contract Awards. Oct 92-Sep 93. FY93. (Sets Technology Inc. - System/Technology Development). Part 17

DTIC Science & Technology

1994-03-01

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Prime Contract Awards Alphabetically by Contractor, By State or Country, and Place, FY 84. Part 11. (Tucker & Associates Contg - Zytron Corporation).

DTIC Science & Technology

1984-01-01

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All Prime Contract Awards by State or Country, Place, and Contractor, FY 87. Part 14. Adelphia, New Jersey-White Sands Missile Range, New Mexico.

DTIC Science & Technology

1987-01-01

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Revised Uniform Summary of Surface Weather Observations for Cape Canaveral, Florida, MSC 747940. Parts A-F

DTIC Science & Technology

1985-04-01

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All Prime Contract Awards by State or Country, Place, and Contractor, FY 87. Part 21. Aberdeen, Washington-Classified Location, Domestic.

DTIC Science & Technology

1987-01-01

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Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 7. (Fahey Watts Architects-General Contract and Sales)

DTIC Science & Technology

1989-01-01

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Prime Contract Awards Alphabetically by Contractor, By State or Country, and Place, FY 84. Part 9. (Potomac Edison Company - Southern Alcohol Fuels, Inc).

DTIC Science & Technology

1984-01-01

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Outpatient Nonavailability Statement Procedures, Health Services Command Catchment Areas, Second Quarter FY 1993 with Comparisons to First Quarter FY 1993

DTIC Science & Technology

1993-04-16

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Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, FY 85. Part 16 (Pilot Electric Co - Reyex Corporation).

DTIC Science & Technology

1985-01-01

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All Prime Contract Awards by State or Country, Place, and Contractor. Part 15 (Amity N. Dakota-Tulsa Oklahoma)

DTIC Science & Technology

1990-01-01

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General Aviation Activity and Avionics Survey

DTIC Science & Technology

1988-01-01

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Geographic List of Prime Contract Awards. Oct 91 - Sep 92. FY92. (Utica New York - Copan Oklahoma)

DTIC Science & Technology

1993-01-01

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Effect of activation of the Ca(2+)-permeable acid-sensing ion channel 1a on focal cerebral ischemia in diabetic rats.

PubMed

Wang, Jie; Wen, Chun-Yan; Cui, Cui-Cui; Xing, Ying

2015-01-01

We investigated the role of acid-sensing ion channel Ia (ASIC1a) expression and changes in intracellular Ca(2+) concentration ([Ca(2+)]) in focal cerebral ischemia after middle cerebral artery occlusion (MCAO) in a rat model of diabetes mellitus (DM). Male Wistar rats (n = 108) were divided into three groups: the MCAO, DM + MCAO, and DM + MCAO + fasudil groups (n = 36 each). Samples were obtained 1, 3, 6, and 24 h after ischemia induction (n = 9). Rats in the DM + MCAO + fasudil group were treated with 1 mg/kg fasudil, a Rho-kinase inhibitor, by caudal vein injection 30 min after MCAO was performed. ASIC1a expression gradually increased with time in the MCAO and DM + MCAO groups (0.71 ± 0.10 nM, 0.80 ± 0.11 nM, 0.86 ± 0.08 nM, 0.93 ± 0.09 nM; 0.86 ± 0.11 nM, 1.05 ± 0.51 nM, 2.42 ± 0.08 nM, 2.78 ± 0.04 nM; pairwise comparisons at each time point, P < 0.05), and was higher in the DM + MCAO than the MCAO group (P < 0.05). [Ca(2+)] gradually increased in the DM + MCAO group (106.32 ± 18.6 nM, 137.84 ± 14.32 nM, 151.94 ± 18.38 nM, 183.61 ± 7.96 nM, P < 0.05). ASIC1a expression and calcium currents were reduced in the DM + MCAO + fasudil group. The overload of intracellular [Ca(2+)] caused by ASIC1a activation could be one mechanism for the aggravation of focal cerebral ischemia in diabetes.

Effect of activation of the Ca2+-permeable acid-sensing ion channel 1a on focal cerebral ischemia in diabetic rats

PubMed Central

Wang, Jie; Wen, Chun-Yan; Cui, Cui-Cui; Xing, Ying

2015-01-01

We investigated the role of acid-sensing ion channel Ia (ASIC1a) expression and changes in intracellular Ca2+ concentration ([Ca2+]) in focal cerebral ischemia after middle cerebral artery occlusion (MCAO) in a rat model of diabetes mellitus (DM). Male Wistar rats (n = 108) were divided into three groups: the MCAO, DM + MCAO, and DM + MCAO + fasudil groups (n = 36 each). Samples were obtained 1, 3, 6, and 24 h after ischemia induction (n = 9). Rats in the DM + MCAO + fasudil group were treated with 1 mg/kg fasudil, a Rho-kinase inhibitor, by caudal vein injection 30 min after MCAO was performed. ASIC1a expression gradually increased with time in the MCAO and DM + MCAO groups (0.71 ± 0.10 nM, 0.80 ± 0.11 nM, 0.86 ± 0.08 nM, 0.93 ± 0.09 nM; 0.86 ± 0.11 nM, 1.05 ± 0.51 nM, 2.42 ± 0.08 nM, 2.78 ± 0.04 nM; pairwise comparisons at each time point, P < 0.05), and was higher in the DM + MCAO than the MCAO group (P < 0.05). [Ca2+] gradually increased in the DM + MCAO group (106.32 ± 18.6 nM, 137.84 ± 14.32 nM, 151.94 ± 18.38 nM, 183.61 ± 7.96 nM, P < 0.05). ASIC1a expression and calcium currents were reduced in the DM + MCAO + fasudil group. The overload of intracellular [Ca2+] caused by ASIC1a activation could be one mechanism for the aggravation of focal cerebral ischemia in diabetes. PMID:26722526

AFOSR Technical Report Summaries

DTIC Science & Technology

1989-06-01

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Microfilm and Computer Full Text of Archival Documents

DTIC Science & Technology

1988-10-13

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Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, FY 88. Part 10. (Hitachi Instruments, Inc.-International Cordage, Inc.)

DTIC Science & Technology

1988-01-01

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M-X Environmental Technical Report. Socioeconomic Impact Estimates for Texas ROI Counties. Detailed Tables.

DTIC Science & Technology

1980-12-22

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Fleet Reliability Assessment Program. Volume 2B. Equipment Report NAVMACS A+.

DTIC Science & Technology

1979-09-01

A4 N’ 0 NM (%M 000 0 N M M -󈧄 N 0 0--0 00-’C0’ 0i 0 0 uj ’I CD- a’ coo a cc~ a’ cc 0 0 C ,: 0 00 cacao ’ 0-M0LA jU’A’ ’C’-I N4’CP-Nww~ww ww W NNN’CN

Early glottic cancer involving the anterior commissure treated by transoral laser cordectomy.

PubMed

Hoffmann, Caroline; Cornu, Nicolas; Hans, Stéphane; Sadoughi, Babak; Badoual, Cécile; Brasnu, Daniel

2016-08-01

Anterior commissure involvement is considered to be a risk factor for poorer outcomes after transoral laser cordectomy (TLC) for early glottic cancer. The objective of this study was to determine the outcomes and relevance of the tumor-node-metastasis (TNM) classification in a large series of patients with early glottic cancer involving the anterior commissure treated by TLC. The clinical and surgical parameters, as well as follow-up results, of the patients treated consecutively for early-stage glottic squamous cell carcinoma involving the anterior commissure (Tis, T1a, T1b, and T2) by transoral CO2 laser cordectomy in an urban academic medical center from January 2001 to March 2013 were analyzed retrospectively. The main outcomes measures were: 5-year disease free survival (DFS), ultimate local control with laser alone, laryngeal preservation, overall-survival (OS) rates, and disease-specific survival (DSS) rates (Kaplan-Meier). Ninety-six patients treated from January 2001 to March 2013 were included. The 5-year DFS and ultimate local control with laser alone rates were 61.7% and 74.4%, respectively. The laryngeal preservation rate was 93.4%; and the OS and DSS rates were 79.2% and 91.5%, respectively. Postoperative T classification (pT) status was not found to be a significant predictor of recurrences, but was predictive of more severe recurrences requiring other treatments than laser. TLC is an effective treatment for early stage glottic cancer involving the anterior commissure. The TNM classification is a relevant prognosis factor for severe recurrences. 4. Laryngoscope, 126:1817-1822, 2016. © 2015 The American Laryngological, Rhinological and Otological Society, Inc.

Fabricated Helicopter Transmission Housing Analysis

DTIC Science & Technology

1975-01-01

collected during the study is included as Appendix II. Additional data on the characteristics of the materials is included in Figures 34 through 39...4H I f- N t-r m oDk in in m Tw 4J0 :D in LO i co 000 1- -r co 0 0 4.) (n MH f IH MH mN (7 N m c N Hm 00 HI 4-1 $4 >1 :10 0 0 0)0 000 0 0 0 0 a 0 * 4

Dollar Summary of Prime Contract Awards by Contractor, State or Country, and Place. Part 5 (Matthew Electric Supply Co-Quantum Research Inc

DTIC Science & Technology

1990-01-01

t4Ie~ r-)6 f- 016240 C c 6-) 0. N. ’)M 40 0 - < qt U..6 ON’)t V- Mw iS.m MM m M w N M v v n I 6- 06.- I wI td -. -N 6 ma toC’ (G. 0- 0g 00 Z-6- o...Into 064 - WI ’a OW)C’IC 00 CO 0 (0( 0- > ’ 0 4 0 td 00 6 4 00 0-4 0 N-N0 0-L) 6-46 4Z ,L- V6 U. 4 I I- 06 so6 00 00 M0 a( 00 E 6-4~1 >- I-- (0- ow...0L L. 0eC) - ) ~ U 0 1- 09 0) .- 4 N (C-0 U) m<t~ (3 4 ans U 06 LL. c I 4 -4 C’). -4 00- 4a 0L to I.L 4 C - w Co- LL a) C 0 > 4 5r~ 5 >O td - - .. >Ci

The Vestibulo-Ocular Reflex in Man during Voluntary Head Oscillation under Three Visual Conditions.

DTIC Science & Technology

1980-07-15

040’- ’ -O 1>, GA 0v WV D Q)G w O V -.-c S -a 𔃾- COd w- Co -w 00 0- > 0000’)-4A-1 j >.M40.M44003.0V - 0 >I4~ .-4-4.AfV Q) - x > I w൰ O QA 101 00...44 : .o w-’ w l mmQzmI , - - v >’ N40 5. a .wx > s , ,w n4 I a wC u C wC CC c a4 0 >E a0 w > 0’ 0x n, r’ w’ I I~ o** 4)-7 r_ C -𔃾 4- C 4 4 -4𔃺 c...8217. 0 a.4A 010 0 GA A-C 00 C :j m >0 0 --0 30. . m0 No-0 m-0.. 0) A-A- . A-.4𔃺m0 0 m-A >7 -O 1N 0C0 0 004w4w0 m0 >O v 0 0 n 4 w .w 0V A0w 0m GAO -0

A screening questionnaire for voice problems after treatment of early glottic cancer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Gogh, Christine D.L. van; Verdonck-de Leeuw, Irma M.; Boon-Kamma, Brigitte A.

Purpose: After treatment for early glottic cancer, a considerable number of patients end up with voice problems interfering with daily life activities. A 5-item screening questionnaire was designed for detection of voice impairment. The purpose of this study is to assess psychometric properties of this questionnaire in clinical practice. Methods and Materials: The questionnaire was completed by 110 controls without voice complaints and 177 patients after radiotherapy or laser surgery for early glottic cancer. Results: Based on normative data of the controls, a score of 5 or less on at least 1 of the 5 questions was considered to statemore » overall voice impairment. Reliability of the questionnaire proved to be good. Voice impairment was reported in 44% of the patients treated with radiotherapy vs. 29% of the patients treated with endoscopic laser surgery. Conclusions: The questionnaire proved to be a reliable, valid, and feasible method to detect voice impairment in daily life. The questionnaire is easy to fill in, and interpretation is straightforward. It is useful for both radiation oncologists and otorhinolaryngologists in their follow-up of patients treated for early glottic cancer.« less

All Prime Contract Awards by State or Country, Place, and Contractor. Part 9 (Annville, Kentucky-Crofton, Maryland)

DTIC Science & Technology

1990-01-01

4.44c V c- U CU4 0 1.- (A 0.0 a* .W - 0. i- -4 C10t- (D I M 6 l UN W 0 >. GN C4 i ae ad )-4N0C, D,0 P. f6 MŔ R~ = 1- (0 00 .8 (A Q 0 0 Zococ3- 00cv I...In 0 P.- CM -4 0 -4 ’I- U u I 000 Go I -16 OC) f6 ’ -4 0A 0 CN - Ll.UC I oo r WNI 00 0 16060 I toN 4: N f 0 L I. I OP.- U -4 -. 4.4 -4 .4.4 .- 46. 4...00 "M M 0i 201(f 1 E00 -4 N)x 0 0 0 Q 0x- 0 0 F6 . Co C4- NI- al 2 0 Wi U) ~ ~ 1. C.) ai a 1 I0 04 N U)N-mN-NN -. 0-4- 1- 4 1.( 4-4 4 (Y00 0 ) -e4 n N

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 7 (Delta Engineering Services - Electronic Design Engr)

DTIC Science & Technology

1990-01-01

M m CV) In4 4 m -nW nmU I C4 innonn 02-40 o . M 1 Ŝ if f8 r- r-4 -V ,MT "f.mmt ,m -P - .I)t )o I Mf *in 040 if -P4-m MI N--4-4-4- PI rI.PP NN 4 0 r...4 U000 0 4 NIO G0.0 se f8 a0 ag0l 000 w00 0040 00c OD 0W040o4O EW 1U-4 £a Oo* -Q4.4 100 040 COO31 00n 00313 00 0-0,0- $.-a£ 40-1 a Uls. 0 0 .4-4 M NN...01.4 0 3 .40iM16t-00t-40.-4 OW 0dM’ t& 0r 0 8o acCa 0 a o o E00 1,12 0008-4 .4 00 0(0A - 3: 60 1 000 00 00 00 0 V0 ( A 1.-*S~ Z.-0N0 -I 0N 4N A)w 0

All Prime Contract Awards by State or Country, Place and Contractor. Part 1. (Alexander City, Alabama-Sevier, Arkansas)

DTIC Science & Technology

1989-01-01

Kf 0-4 a -54 -4.4.4 -4 4 -0 w.4 (0 c 0 W.4 0(0c 0.4 Oafs Oafs 0o l- Kom 0 ene (04 Kn m0 m 00000000 C2,40-4 0cr 00 ON4 on 00 00 to (04t KfC 4C N N...0 m-4 CD-C C00 N on VN Nli00 410-IOCD N In 4N T10 N0 01 C- 004 or-, 0)0-4-400V) 004- 00 -4 Infin I I C -C1 I4N Nf r- CY) 00 N-4 1-’ M 00 CO COO -4

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 6 (Colson Equipment Inc-Delta Engineering Inc)

DTIC Science & Technology

1990-01-01

4NN cow -i =0 an 0 10 fta e ~ fw w w 0-4N a NaL00N0 nop-- N- Do 00) (0 00 (0 ft - 4. = 4N0 a Vtfttf. fftfftfttfVftfft v . ,C)e)mmmmV V)f ft co0 ft ft...4 i N CNNNN N * 0 Oft Kx 0C 0 0C 44 C -cc0 44 4C *ON W W 0 A 0C K U3-4 :oz 02 02 0-’- 0- 0)- 0- 02z 0) - 0---- 0)- K c) : M.f K fta ftI 0M 0 Mt 0 ft... FMD MIo 4 0c U010- L. to P I -- N-4 to 140 w Mc-I. .0-4- .- 4-II-a-4 ccI Co .-I -40 am U 0 I M0 Rr a 0 0 0n~n~ 000w4 n InnOf~n~ 00 00 0- M C C U I

Enzymatic Conversion of Red Cells for Transfusion.

DTIC Science & Technology

1979-11-19

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Alpha List of Prime Contract Awards. Oct 91 - Sep 92. FY 92 (Branscome Julius Inc - Chriscott Supply)

DTIC Science & Technology

1993-01-01

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Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, Fiscal Year 1987. Part 11. Kodet Architectural Group-Mantech Field Engineering.

DTIC Science & Technology

1987-01-01

8217’ C4J C >)> Cm (0 C’) C- ir40 0 -4-4N (4 0 0 .- .>’ .- . ~ - - C 4NL.4- N04.. (0 M’) C -00)0 N U C -(D tD C ,’ m0 0- r, O N N 0 V I- CNFL O4 .0 U 0...10 0646I 0- -I WN 0 Z-D0 I-C’ C-C’) 01 O 6-0 C’)’ C’) 0 ’-40 0l11 0 0 CD C’)U CC C ) TD N0l 06 N- 0.60 00 00000 on 00 0, C. C 000 00 00 000) _𔃺 -’l) U...W LJ "- C C :34 N m4 1 0 w 4 n-it un w N nN r, v 3- 4bD )n0wt400 040 cCO 0n 00 V cl 00a) C)O0LA m-4 I4 N 0413 4 VMPP,?-0V VN 4 (D W 04 4O(D0) 00 cc -4

All Prime Contract Awards by State or Country, Place, and Contractor, FY 87. Part 22. Antigua AN-Indonesia.

DTIC Science & Technology

1987-01-01

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Prime Contractors with Awards Over $25,000 by Name, Location, and Contract Number. Part 10. (Tucson Electric Power Company-ZYW Corp.)

DTIC Science & Technology

1989-01-01

Af 0 -DO T 1 -40 Nr 4. m 40 - mML ’ -4~t 40j COI-M i m -~ IL 4-0o N2 U - .4 t ~ - mI-t-N0 t 6 ) 0 2 04N02- 4 (0 C> m DC O 00 -r-m O- > N N 011 CN mC...ac .0 OlE) L E0 E’. C). > 4-C X: C) 4C- 4-.3o oI C C) . CC4-C4-C -E C 0 404C ) Czt ) C’’ 3 ’ C C cc0C ) CC C.’~ O C) C---( 0 CC0*-.C) 0 C C --. C

Air Force Boom Event Analyzer Recorder (BEAR): Comparison with NASA Boom Measurement System

DTIC Science & Technology

1988-07-01

Hemisphere Foam ined stee e ’/ To BEAR. V ib rat ionSeaainDsnc Isolated Nylon m icohn older 3/8ŕ - 18 Diameter Painted Steel Plate Figure 9. AAMRL...d3 0nw Fiur 2. 0 SFBom petrm omarso 38w 0 0- 0 In- WW LL. 0 In 0 to 0 to 0 to 0 to 0 N\\ N - - 0 0 m M OD D (M8 ZHII (SP) -13A3-1 vvnflNL33S 38flsOdX3...ONflos Figure 27. 8 PSF Clean Boom Spectrum Comparison 39 0 0)0LZO (0 < -r- a- U I 0 IL) zw _0 U.) (M1 to) 0 Ito 0 to) 0 to 0 to) 0 N~ N - 0 0 M ) CD O

All Prime Contract Awards by State or Country, Place and Contractor. Part 15. (Ada, Oklahoma-Zelienople, Pennsylvania)

DTIC Science & Technology

1989-01-01

N " l l 4C -440 W -4"< N ic>->-* X00 -AcN = N .CN .g(cwwwwwwwflf* Jc C .x((0Cl(0l* w NEI 0-40 N022 02 02 02 02 022222222 02 02Z222z don Z I a I I I I...de L) cc < M L- I.- H OcH 0 a 4c I.- I- 0.. 4- 4 -LIn WHIM N HO 0 z 0 cc z 0 0 40 Z HC I doN a 4-4 Woo Z 0)- @ 0 0 -- W 0 L- =40 1-4I 0 004N HO 9m- 4...4 - cv) Ia)OL o j n I.- N W I Cc r-4 If Z 00000CA4-W z if E I m) N4 10 ~ LA . . .L. LLIA.L. 0I 0 Nf m I doN N" " L)))))00000 mommmom’ -W u N 2 I

All Prime Contract Awards by State or Country, Place, and Contractor, FY 85. Part 6 (Alachua, Florida - Winder, Georgia).

DTIC Science & Technology

1985-01-01

4aC I 00 < M Uz 00(000000cc0000000001. U 0LALLAAOO 104I < 40(0OO0O4NN0.I-C10 ml W N00NNNN-4-I - M I .00 . . ~ .’l ~ C 0 0 .0- . .. . WWW W0r.000O LA...40 -4 -4 -V4I, 0.2c W~n r-. CLn U). C CC rA. IA. I ca 0 sO N 4 r4-4 4 --*L -qU l4 .00)L . m -IU NY mQ 4 *ww4CI www "Mm<)C, C’ oC)Co ) -IC44 -40 .. 40)C...10 ) -4 0 N 0 * C 1) 0 0N0 0 N 0 0 00’ mo oo* 𔃺 (0’ 4-’ in L4)4)-)- -n =0 0 0M- =OO- = 0. 30w~ww -4c) -4w www -40) -4-4n~ - -4mmac L44 0-- 403 01 0

Prime Contract Awards Alphabetically by Contractor, By State or Country, and Place, FY 84. Part 6. (Holcomb Construction - Kwickstok, Inc).

DTIC Science & Technology

1984-01-01

EEEEEEllllhUEEEEE.l EhlllhhEEEEEEEEElllll mEEEEEEEllllllhlllhEil .L.- a ji i~ liliiii m °’. MICROCOPY RESOLUTION TEST C4’MT NATIONAL BUREAU OF STANDAIRDS.1963-A...00- -0017 - If) NO .0 V 0--0 0- 0 (of, CD -- N N - 0 -- f- N 0)- -N a) CD CONI * 0 V1000N 00 NY 00 000- 00 Mo00 000q m IT 0- x 4c U 0Y - m NN CY...W z M E 0aI ɜ < 4c 4c40 C.040000 I 0 0 0 00 ~0 1010 00 000000.4CD 00 4 0 0 0 0 40 0000 .000.l 00 0 0 0 00 0 00 00 000000 0o MOM00 NN 0) Nu (A

Prime Contractors with Awards Over $25,000 by Name, Location, and Contract Number, Fiscal Year 87. Part 12. United Steel & Wire Company-Zynar, Incorporated.

DTIC Science & Technology

1987-01-01

00 Z C. 4 9 > > t ’r z> >> > > > > I Z C0 0 K r . 50 F580 0 9000 > >> > > >> > > > 4444 Cd~dd > IL . *’% IP ~ ~ V -,~.: :<~ ID O* 0040C\\ t- O O1’INMN N...04 - CC 00 0 .4L 00000 . Ze) L) Sz0 Z3 :333 0%3 : m U3 0.w Ip w ? L) s u H U 0 7 Z 7- u cc 5 m 00 w~ > I w~ : < en 20 WI CW m : ) A e u0 000 00 WLLSW...ON a’ OD 0.0V .. N-0 t- 0 N 0DM a 0 4 N cc r0!0 w . Vw w w mw0wwm wc V m 0 0~. .0 0 0) Voz . Nw( g-) 00 m 1 0c 0 C00 00 N 0-Mm0mV 0 0 0 -Cmm e) 0 - V f

DoD Statistical Report on the Military Retirement System. Fiscal Year 1983.

DTIC Science & Technology

1983-01-01

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Official Guard and Reserve Manpower Strengths and Statistics, FY 1985 Summary

DTIC Science & Technology

1985-01-01

0 4% 40 4 .M 40 N M 4 41 4j 4 19i0 p 0M .49 1 41 4 0 4 M N 0 4Z4 O 4 4 " N4-4 49 4yo 41 1 4 4 49-4n l (Y 0 p 0 Mi i0 404U4in aV% 10 wi0 . 41 OD m 144...AM M - o 0v i 4K 41 4 4yo * 41 4 4 49- 4o . 4 S04 4 4t on4 4 1-0 140q 𔃺 0-I t- fmW 60q-I n 9 4K4 4 U 0Al 410-41 4u I" 4 4. 4j "M0 4LU4 f q 404 4K

Prime Contract Awards by State or Country, Place and Contractor. Part 13 (New London, Ohio - Westerly, Rhode Island), FY1991

DTIC Science & Technology

1991-01-01

u I (04q N -iLifLn-i0)00 .- Cl) -- If .’t- -- 400 r1I- -4-. M(𔄁 . "I XN 1,- 1I to I (04e 11 1f4.-400𔃾 in -f o~n InJ N L0304 toN 0n (no U O 4 vUN 0...o CN M C) a) "൒ -’ 14"to0" C>(W P 00(W0t- 00m 0- --4 C~nC’ r-- KooN 400 0 -4-4 a0(D0)( w 4(1(0 -4 * 4m( 0-4 m0000000CC>C0 -4"K 4OI 41 CC D>)- 000C

Characterization of moclobemide N-oxidation in human liver microsomes.

PubMed

Hoskins, J; Shenfield, G; Murray, M; Gross, A

2001-07-01

1. Moclobemide underdergoes morpholine ring N-oxidation to form a major metabolite in plasma Rol2-5637. 2. The kinetics of moclobemide N-oxidation in human liver microsomes (HLM) (n = 6) have been investigated and the mixed-function oxidase enzymes catalysing this reaction have been identified using inhibition, enzyme correlation, altered pH and heat pretreatment experiments. 3. N-oxidation followed single enzyme Michealis-Menten kinetics (0.02-4.0 mm). Km app and Vmax ranged from 0.48 to 1.35 mM (mean +/- SD) 0.77 +/- 0.34 mM) and 0.22 to 2.15 nmol mg(-1) min(-1) (1.39 +/- 0.80 nmol mg(-1) respectively. 4. The N-oxidation of moclobemide strongly correlated with benzydamine N-oxidation a probe reaction for flavin-containing monoxygenase (FMO) activity (0.1 mM moclobemide, rs = 0.81, p < 0.005; 4 mM moclobemide, rs = 0.94, p = 0.0001). Correlations were observed between moclobemide N-oxidation and specific cytochromre P450 (CYP) activities at both moclobemide concentrations (0.1 mM moclobemide, CYP2C19 0.66, p < 0.05; 4 mM moclobemide, CYP2E1 rs = 0.56, p < 0.05). 5. The general P450 inhibitor, N-benzylimidazole, did not affect the rate of Rol2-5637 formation (0% inhibition versus control) (at 1.3 mM moclobemide. Furthermore, the rate of Ro12-5637 formation in HLM was unaffected by inhibitors Or substrates of specific P450s (< 10% inhibition versus control). 6. Heat pretreatment of HLM in the absence of NADPH (inactivating FMOs) resulted in 97% inhibition of Ro12-5637 formation. N-oxidation activity was greatest when incubated at pH 8.5. These results ilre consistent with the reaction being FMO medialtetd . 7. In conclusion, moclobemide N-oxidation activity has been observed in HLM in vitro and the reaction is predominantly catalysed by FMOs with a potentially small contribution from cytochrome P450 isoforms.

Alpha List of Prime Contract Awards. Oct 92-Sep 93. FY93. (Martinez Architects Inc. - Nihon Boshoku Kogyo KK)

DTIC Science & Technology

1994-03-01

0 0 .-4 -4 -’.-4 00 00 0 00 0 0 0 0 0 0 00 0 0 0 u If C 1 00Of I 11-NW CV) CV) NoNm N NC~ f qCqC f V)m()C O n( CV)’C) enC’ m’ Of m C") Oil I O C0...1 C Y)im mn c )0)()o 0 mmmmmfmmmmmmmmmmm om m) Of mY )1)O )C)CY 7 Y f 11 C I 0 W 110 If I nc-N 11LU) 00 (n If I CO N i’l11- < Go Co- oil I toON w I...0ý-4-4.-00 0 0 0 0 4.4.4.4000000000 UII1 lCo l II MlNN1 meym N C Cl MCl C.) NN N l(14~llll~~ Oil I cool II-..001001000 (T) 01) 01 01 01

All Prime Contract Awards by State or Country, Place, and Contractor, FY 85. Part 18 (Addison, Vermont - Wytheville, Virginia).

DTIC Science & Technology

1985-01-01

cO c C.-4 a cO CO c 0 _ co 3 0 0 0 0 0 0 0 0 0 0 0 0 0In m )EN ENC ~ E- ENC ENl E -4 ENC1 E .4 ENC ENC1 ENC E ENC ’ CL 0I I...4 g 1U I 4 cv)C() Cl) -4 C14-4 eNC C’) .04 6- us 511 ZOI CD nmos a.C woo 10S c mm m m i o.-.*In~mn V L nL L nL L n * -c I 0 0 0 0 00 0 0 0 0 $i Ml 0...NNNNNNNNNNNNN0) 00) Mooɘ I E000) E to E 4 Ec,) ENc , E a E 0 -0 E - - - v-* v -*v 4 -e -N E N I- < I I< w0 l 0 w04 L7C, mO <n mO .O .n . . .NNNN NN-14< I-I 00 00

Alpha List of Prime Contract Awards. Oct 91 - Sep 92. FY 92 (H E P incicn Biomedicals Inc)

DTIC Science & Technology

1993-01-01

ea -IL. U-’ 4n0) 0)0) 0) it 4 I CO00>-I If f7 )"’.lNNNjNjNNN -IE m J-J NJCA a < 04 0-v 00 a4’ 40000L)O < 11 0 1M 0 -4 110a(w(0w(0(0(W0W0(D( -44 044 U...4 It MO0M It M) 00 NCO-1-10101000tIn N410441- N" 0 00 (0-410 f.-I to 01 11MI C . - aCCa )0 0 0-40000 000001 Ř 4 0 0 00C 0U to 01 11 i i-N N1 N- NN NN

Cirrus Particle Distribution Study. Part 6

DTIC Science & Technology

1980-09-04

b 546- 0 W N . 0. 655- 0.4 M.5.41fl U MCU n 104 N fU% OMMN (O 0 0 W 5.5 P)D. %n ))UUU U) M) I. W52 ,Ir N.4 C’,00 )00 ))5’)) I) U ISO ~-1 04 OC O CfC... 27001 ’f400 0 C 0 ;: 30 ~ of a. 0.87 a4444 00 P N * . .’ .~. .44...0 0 . L;8’ 0 8-08 a n 0P " o0os, -O M C t0 2i Ws, 2,W-’ NM2r-r ~ OW0 0W I -Vf 0VW roe

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 5 (CSR INC-Colson Business Systems Inc)

DTIC Science & Technology

1990-01-01

000 00 4U I CON U4 a’ 2 3- ’- 001-- I M3 ON U4 4C 2 w w 002 CDZ Co QOUGI N U~s I 1- 1 * 0 0 2 0 000 00 < U 0 I ON U 00 2 I ZNS 0N0!0v)1.- 00000-1 Col...W of M- If’ H c -40oo04 0 0. -40 0C0 040 I Io 00 II M000M. 00 M000. 000 004M 0) 00- 000 L) IO coM 1 00 0044 f-4 in a*0) -4 0r14 - -G o I cON I l 0 0...Moo O I N ca fl00 0000 -. 0 0 0) 0U 00 0 0C) M Mj a l 4I0I ON I4 Wr 01-li N 0C-.J i -Nm-W)- r SIt2 I CON I ClI 4 0 M- I.0 1-1 1N O 01 41 39 1 IO ON

Terminal Area Forecasts, FY 1993-2005

DTIC Science & Technology

1993-07-01

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All Prime Contract Awards by State or Country, Place, and Contractor. Part 11 (Methuen, Mass-Winsted, Minnesota)

DTIC Science & Technology

1990-01-01

4 N GAo (0 C2N 11 .12a- 0. ir El 02- 110L 0 Ix .m I M -4 If CU U.w 1 M-4 it 0. .NNj00 00 00 000 ( 0e(ON0r-C400 Dc4c0c)c nr - 4 o-4 - 4 ( or- 41.n0...N N N NNIN NNNN""J.. .. "N6-Jt.. .. . .. .. 6% JINI oN IftG 4 0*’,fL N 44 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 444C 4 N -4j ca)0 0 IMZZ Z Z Z Z Z Z ZZ Z Z...M In c’) w o-4 um am aW-a4 a Gao Winul)U)U)) 00 1,17im)ala) L" 0 00 Q a (1) U ) n) U 0 ma 0-4 amcC) C(NNNN.N.NNNNNNN c3 ca-.- C)- CNN cQ w coo maaM

Prime Contract Awards Over $25,000 by Major System, Contractor and State. Part 2. (BSH-SMR)

DTIC Science & Technology

1989-01-01

tI CI 4) 0 w- - 4~4 C -*. nowO )-4o -040 0 OL*l (M m 100m-1-1v-qmm 00L -t(M- 04-X 4nII W- --4Ww .nw -. 4-.M -- 4WC W-4LA -4 0QW U C W 40Ř 0-* W...L AL 0 0. J 2W -4~ 00 00L37 00 00 0U 00: 0v a0 0 04 0A < ) - 347 =N- -440 C’ ) .rN- . )-4 ~4 -4l C) M - 0 0(I) -IL.I0 Lb f 0UC0 C’ 03 U7-t0U -4N U

All Prime Contract Awards by State or Country, Place, and Contractor, FY 87. Part 19. Abilene, Texas-Winooski, Vermont.

DTIC Science & Technology

1987-01-01

3- 3 )L .U ru ,u L- -3- u- % -4 1 I Coe 4") C, CN-40) go )N MOLA ( 0. -m .Z 04Z 0N( r 4 0 4NZCl 3 00 0I(400CZ 3-1(0 COO -0) NLA-o _0 000 000 >- 0 -40...tLOA- 4L -40U CC WOO (00 >0 C-.4 C(* C0 C (D CD coD O c .0-4-4 iv00 m co 0)00 )@0 co C’) iv (D 4o (0@0 < 430 40 m00 m 4m0 mOLA 400) ))4 0-4 ,C0) 4-0)@00...4030 0 o mw04 ’- 0 0 0 1-444 -)04 "NN N4 "-F-’ N. 4 -- 4 M 4 -Ln Mw 0’- IL00 IK to V) 0W . (Afl(AL (AAIx M-4 MOLA mwwwwwmw0C) ~ C- 0󈧭 0- 4 - 4 . 4

IONCAP Prediction-Based Automatic Link Establishment (ALE) Frequency Selection for a Ten-Node Australian High-Frequency Network

DTIC Science & Technology

1994-07-11

r. H %D -% P. Ilt %D 𔃺 in @ 1 %D% qv .~ m ’ S 4’ qwv nI"mm0" qva 0% 0% m% 0% 0% 0% 0% 4% 0% m’𔃾~ M 4 M enN9 e N N r4 V4 M P4 4 V4 4 N m 0%Cha %a 0% 0...3422). Reviewed and Approved: I 1 July 1994 Head, Submarine Electromagnetic Systems Department d REPORT DOCUMENTATION PAGE OMB Ao. 0700185 I I ow idd...SA me. muec de WW eew I igaid go Sevbad id WNmL SOW id S tlnm US kud.. uiliSŚy 1 1 aps 0" Wes ftf 12K0u -VAs.a mqgdumS asii Ut buADs Wila We~ham P

Combating Weapons of Mass Destruction: Models, Complexity, and Algorithms in Complex Dynamic and Evolving Networks

DTIC Science & Technology

2015-11-01

NLP Blondel Oslom Infomap 0 0.2 0.4 0.6 0.8 1 0 0.2 0.4 0.6 0.8 1 N M I (N = 5 0 0 0 ) µ SCD SCD- NLP Blondel Oslom Infomap A...Networks with minC ,maxC unconstrained. 0 0.2 0.4 0.6 0.8 1 0 0.2 0.4 0.6 0.8 1 N M I (N = 1 0 0 0 ) µ SCD SCD- NLP Blondel Oslom Infomap 0...0.2 0.4 0.6 0.8 1 0 0.2 0.4 0.6 0.8 1 N M I (N = 5 0 0 0 ) µ SCD SCD- NLP Blondel Oslom Infomap B

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, Fiscal Year 1987. Part 17. Southwest Ordnance Supply-Taylor-Made Hose, Incorporated.

DTIC Science & Technology

1987-01-01

wowI -4’w =0 00000 Mono0 win t-2 0000000000000 ’-a S.0 0 - 4c-4.c "N180 8m"--40 -00w M -C 1-4 V0M enC r-en0s-4 --- M M V 0P W0 0 f-- ’- P-4 M-0N 4 N I00...0) 0000000000000 T r-< 40 -40( 0 ’ (0 0 0 4 -V W( L04 400 Z4444 LADO at (L. a L/4 0I 4 -0 LA 4 00 0n L&0 ( 1/0 0 0 040 0 0NN 400 (A 0404 -44 (0 (0 LA...8217-4 6n 0 NCN4 toIrj a - cQ r-j r, LA enC > 1-1- -O (0NN r.~ rON ( N 00 C C,4 r4 CAN r- ) I C) a 0 0- 10 L0 0O0 I. 4 NC 1 L A 0 𔃺 4 - .4 LL L )’ 0 W I C

Geographic List of Prime Contract Awards. Oct 91 - Sep 92. FY92. (Goodells Michigan - Warrenton Missouri)

DTIC Science & Technology

1993-01-01

q -f-i o0-1-4 -t- IM. 0,11(14o0 M0000-4 it 0000 o 474I 40)m0) 0 00C(1~ (.0 0 -4"( m m 420 co0m) 0(D (D 0 44200 44 400 44M 000 C)C -4 -1 4 -- 4 0, - 0...N : 44200 0 at 0.4 1- V0 0i Ix 0- 001 40 L0 0- 0 0)N01 c H4 , M0oN " #O--) "-,)I-- 0:3 00 0 0 1- -1 01 - "-4 2> >- Ct0 00-D-- -114 0 1 £0ON 44 444<ɚ

Official Guard and Reserve Manpower Strengths and Statistics. Summary, End Fiscal Year 1990

DTIC Science & Technology

1990-01-01

c.c-onN N ’ . N0 a a - n 4 o* a a a cci.41A a>-a ar acca a ITa an aC,- an a rN-M in 19 .a~w aor. 0 -c N N 0.-c~ an2 U)r an cc a, V, g a al Ixin 00...0 C NOO .30 555 55 31- NO CIA ku cc w C9* m 5r 05 Z5 , *~~~~~~ m O-4 0 .3 *~ ~ Q 0 1.N.00 00. m 5n in a* T , S * : U- 5 *n -I n I . >-* 53 5 0 a P7 0

Dollar Summary of Prime Contract Awards by State, County, Contractor, and Place, FY 85. Part 2 (Adams, Indiana - Yancey, North Carolina).

DTIC Science & Technology

1985-01-01

M 00 4 0 0 fn N&- 4 C4...I0 in 1- cm m 07) 00 toPP 0 1~c it -40. v;- .40 N04N,0 0 0 0 0 W:no - Wi0 a -0 I 4- wan f - 4 N0n0 00 4NaqN I. 00 - 1-a V24~ ONl N 0V I- tO I* 0 wa r... m 14 I 00. ira 4 I- 1 0 1 .4 .4 se o ev e wes0e N07s ess 0sees 0 I.- ZI 0 a a 3t I I ’* 4. r- : I I’" 0o. I Za NN 07an 070)0 0 070 0000000N0.4 . 0

A Modified Double Monte Carlo Technique to Approximate Reliability Confidence Limits of Systems with Components Characterized by the Weibull Distribution.

DTIC Science & Technology

1980-12-01

m ~ 1O ,-4 - 0 r-- o4 0 0 0 0) 0 0) 0 C) 0 0 0 o 0 0 0 0 0 0 0 0 0 0 0 N~ t- 10 m ~ m v t - 0 t...8217- 10 00 m ~ o 0 m ~ w r-l m ~ (D wcc C’ O1 q1I t - t- wc mD t- 0 10 N’ r- 0 1-1 o- 0 0 0 0 0 r-A 0 0 0 0 0 o 0 0C) 0 0 0 0 C) 0 0 0 - ~ t- t- m ~ cc wc N m m ...10 0 mc m ’- C 0 0 r-i 0 C) r-I 0 0 0 0 0 4-4) 0 0 0 0 0 0 0 0 C 0 C)H -qc)cic) o 0 D 00 4- a)mNC0 ( ) - O c Y 0 0 cc C’] cc 00 r4 LO CD) cc 0 cq

CMB and the elementary particles structure deduced from QFT of non-dot model

NASA Astrophysics Data System (ADS)

Chen, Shao-Guang

In my paper ‘Planck Constant Deduced from Metrical Results of Doppler Effect of Moving Particle —Uncertainty Principle Caused by Collision of a Particle with CMB Photons and Virtual Photons (H05-0036-10)’ the absolute velocity is decided by CMB which as a mark of the vacuum. CMB come from the thermal radiation of stars via gravitational redshift about 10 (13) year (E14- 0032-08). In my paper ‘Quanta turn-advance ism, China Science && Technology Overview 131 192-210 (2011)’, QFT four-dimensional uncertainty principle and momentum-energy conservation law had been generalized as a five-dimensional equations: de Broglie wavelength as a position vector \\underline{q}= (i c t, r, s), momentum \\underline{P} = (i E / c, P, U c), \\underline{q} = i h / \\underline{P}, \\underline{q} \\underline{q} = 0, \\underline{P} \\underline{P} = 0, Sigma∑ \\underline{P} = \\underline{P} (0) . The five-dimensional time-space-spin had been quantized as a non-dot model basic cell, the lowest energy state vertical polarized left spin 1/2 neutrino and right spin 1/2 antineutrino are just the left, right advance unit quanta _{0}nuυ, nuυ _{0} and left, right back unit quanta (0) nuυ, nuυ (0) , it again compose into spin 1 unit advance photons _{0}nuυnuυ _{0} and back (0) nuυnuυ (0) , spin 0 unit rest mass nuυ _{0}nuυ (0) and anti-mass _{0}nuυ (0) nuυ, spin 0 unit positive charge _{0}nuυnuυ (0) and negative charge nuυ _{0} (0) nuυ. It accord to the high energy physics experimental results of the transformation among the photons, masses quanta and charges quanta. The physical vacuum is the even collocation of non-combinational nuυ _{0} or _{0}nuυ. QFT is no longer with divergence difficulty by the non-dot model. It is mathematically easy that from five-dimensional equations deduce out the Dirac, Klein-Gordan, Maxwell equations and Lorentz force formula, but appear some new results. The interactions between _{0}nuυ, nuυ _{0}, (0) nuυ, nuυ (0) , i.e., force f = ± ( h c / 2 r (3) ) r cos thetaθ for r not equal to 0 and f = 0 for r = 0, f as the magnetic force makes the photons, rest mass and charge quanta automatically come into being and stabilize. CMB photon can be produced from many spin 1 unit photons by its statistical attraction. In the quantized inconsecutive time-space-spin using momentum and turn-quantity as the coordinates drawing the momentum-turn graphics are some points with certain distance. The rest mass m _{0} is the lowest energy state advance-back neutrinos pair nuυ _{0}nuυ (0) , when j direction have 2n nuυ_{0} the i , k directions must have (2n-1), (2n+1) nuυ_{0} for i, j, k three directions all matching into pair to eliminate the external interaction of electric quantity q(0) in nuυ_{0}. The spatial rest mass is quanta (n) m _{0} = (2n - 1) 2n (2n +1) m (0) = 6, 60, 210, 504, 990, 1716 m (0) , m (0) is the rest mass of nuυ_{0} (also anti-mass (n) \\underline{m}_{0} and \\underline{m}(0) ). According to the uncertainty principle n large rest mass layer is more little and at the inside layer of particle. The spatial unit charge quanta e or \\underline{e} is constituted by nine one-dimensional unit charge quanta nuυ_{0}(0) nuυ or _{0}nuυnuυ (0) because of the vertical polarization at each spatial direction there is only three states: the left, the right and the middle of left-right balance. Via photons, rest mass and charge quanta all elementary particles come from _{0}nuυ, nuυ_{0}, (0) nuυ, nuυ (0) . The particle’s momentum is constituted by the photons _{0}nuυnuυ _{0} or (0) nuυnuυ (0) and a few nuυ _{0} or _{0}nuυ. The particle’s charge is constituted by one e or \\underline{e} and one nuυ _{0} or _{0}nuυ. The particle’s rest mass is constituted by one or several (n) m _{0} or (n) \\underline{m} _{0}. According to the uncertainty principle n large rest mass layer is more little and at the inside layer of particle. The left spin 1/2 nu υ _{mu}: 1 _{0}nuυ + 1 (n) \\underline{m} _{0}, right spin 1/2 nuυ _{mu}: 1 nuυ _{0} +1 (n) m _{0}. The e (+) :1 nuυ _{0 } +1 \\underline{e} (9 _{0} nuυnuυ (0) ) + 1 (5) \\underline{m} _{0} + 6 (2) \\underline{m} _{0} , with one positive electron charge q (+) (9.5 _{0}nuυnuυ (0) ) and rest anti- mass (990+6*60)= 1350 \\underline{m} _{nu}. The e (-) : 1 _{0}nuυ +1 e (9 nuυ_{0} (0) nuυ) + (5) m _{0} + 6 (2) m_{0} with one electron charge q (-) (9.5 nuυ}_{0}(0) nuυ) and rest mass (990+6*60)=1350 m_{nu}. The electronic mass m_{e} = 1+18+1350 = 1369 m _{nu} , V = m_{nu} c /m = 219 km/s which accord to the solar system speed of astronomy observation and as a reason of the electronic stabilization. The neutral electron nuυ_{mu} (0) ( (0) nuυ_{mu}): 1 nuυ _{0} ( _{0} nuυ) + 3 (1) m _{0} (18 m _{nu}) + 6 (2) m _{0} + (5) m _{0} =1369 m_{nu} (\\underline{m} _{nu}). They are as the nu υ _{mu} and \\underline{nu υ}_{mu} with electronic mass and only in the weak interaction which maybe had been observed in the neutrinos but in the dark. With (0) nuυ_{mu} and nuυ_{mu} (0) as new unit compose the elementary particles. The (n) m ((n) \\underline{m}) = (2n-1) 2n (2n+1) m_{e} (\\underline{m}_{e}). The piπ (0) meson: (1) m + (2) m (66 m _{e}) is the flat shape, for the spatial symmetry two superposition to ({2) -1} m (2) (132 m _{e}), again with ({2) -1} \\underline{m} (2) (132 \\underline{m} _{e}) compose into piπ (0) meson with rest mass 264 m _{e}. The mu (-) and mu (+) : (3) m ( (3) \\underline{m}) outside layer i, j, k each direction one nuυ _{mu} (0) ( (0) nuυ_{mu}) to be replaced by one _{0} nuυ and e (nuυ _{0} and \\underline{e}), its rest mass is ( 210 - 3 + (19/1369)) m _{e} (\\underline{m}_{e}) = 207.02 m_{e} (\\underline{m}_{e}). The piπ (-) and piπ (+) : muμ (-) + ({2) -1} m = piπ (-) with 273.02 m _{e}, muμ (+) + ({2) -1} m _{e} =piπ (+) with 273.02 m _{e} (n) m _{e} = 6, 60, 210, 504, 990, 1716 m _{e} (\\underline{m} _{e}) still come into existent, m _{e} is the rest mass of electron. The p (+) and p (-) : (5) m + (4) m + ({3) }m + ({2) -1}m(2) = 1836 m_{e}, its outside layer is (2) m_{0} ({2) }(120 m _{nu}), \\underline{e} (18 m _{nu}) and one _{0} nuυ with 139 m_{nu} = (139/1369) m _{e} = 0.1 m_{e}, it is just the proton p (+) with 1836.10 m_{e}. The antiproton p (-) : with 1836.10 \\underline{m}_{e}, one e and one nuυ_{0}. The n and \\underline{n} : In p (+) outside layer the _{0} nuυ (1 m _{nu} ), e (18 m_{nu}) and (2) m_{0} (2) (120 m _{nu}) are replaced by two nuυ_{mu}(0) and one sub-nuυ_{mu} (0) which (5) m_{0} exchange into (4) m_{0}) become 1838.64 m_{e}), again absorb one vacuum nuυ_{0} become the neutron n. The anti-neutron n has 1838.64 \\underline{m}_{e} and one _{0}nuυ. The essence of strangeness is that: one left turn anti-mass ({2) -1} \\underline{m}(2) (132 m_{e}) interfuse in great right mass particle then the strange number S = -1, such as K (0) , LambdaΛ(0) , Sigma∑(0,+,-) , two (2-1) \\underline{m}(2) then S = -2 such as XiΞ(0,-) ; one right turn mass ({2) -1}m(2) (132 m_{e}) interfuse in great left turn anti-mass particle then the strange number S = + 1 such as \\underline{K}(0) , \\underline{LambdaΛ} (0) , \\underline{Sigma∑}(0,+,-) , two ({2) -1}m(2) then S = + 2 such as \\underline{XiΞ}(0,-) . All strange particles as positive -negative pair to be produced from the particle’s momentum in accelerator, on the fountainhead, all come from the neutral microwave photons. Only from the collective structure of the photons, rest mass and charge quanta we can understand the strange particles producing process and the strange number invariable law. From the structure of elementary particles it may be obtained that the gravitational constant is likely dependent on the absolute velocity of galaxy.

Computer Generation of Fourier Transform Libraries for Distributed Memory Architectures

DTIC Science & Technology

2010-12-01

m + m -1] = A (x[i*n:1:i* m + m -1]); y = (Am ⊗ In )x y = ( n−1 ∑ j=0 S (h j ,n )AmG(h j ,n ) ) x for(i=0;i<n;i++) y[i:n:i+ m -1] = A (x[i:n:i+ m -1]); y = (In ⊗ Am...L mn n x y = ( n−1 ∑ j=0 S (h jm,1)AmG(h j ,n ) ) x for(i=0;i<n;i++) y[i*n:1:i* m + m -1] = A (x[i:n:i+ m -1]); TABLE 2.4: Translating SPL to Σ-SPL, and then...Ip ⊗‖ (Am ⊗ Iµ))(L mn m ⊗̄Iµ) → p−1 ∑ k=0 ‖ SDT(qk,n/µ,µ)

Dollar Summary of Prime Contract Awards by State, Place and Contractor, FY 85. Part 1 (Alexandria, Alabama - Yorkville, Illinois.

DTIC Science & Technology

1985-01-01

m - zago zi 9zs 0 m U)l 4c140 0 "< z( . 40 21 I z)-0 "o 0 W 0 >W~ zl "I 00 (04It06 lN t04 01 U (i C0...IU I. In 4c * NO a 05 ’ 44 E - I I A 0 CO I q~o c N M inI5V F z I. I. . .- 01 I- 0. 0 -1Nc4 .4 CL C N- (ogo - C- z I.- w R a. A0 w . z 0 0-I" 14.$A I9...a.n GoCV)t-0 a C1 m n m ’ I. CVI CV in OD) N C) 4 0 ~ ~~ a . r a O aca 40 Z au ’ FJ.. *.4hmN 0- I : N 1 04 1 I. *c’ a-J a 00C)r P oI 4 a . 9 -4 .a a

Gravitational constant is likely dependent on the absolute velocity of galaxy

NASA Astrophysics Data System (ADS)

Chen, Shao-Guang

In my paper ‘Quanta turn-advance ism, China Science && Technology Overview 131 192-210 (2011)’, QFT four-dimensional uncertainty principle and momentum-energy conservation law had been generalized as a five-dimensional equations: de Broglie wavelength as a position vector \\underline{q}= (i c t, r, s), momentum \\underline{P} = (i E/c, P, U c), \\underline{q} = i h / \\underline{P}, \\underline{q} \\underline{q} = 0, \\underline{P} \\underline{P} = 0, Sigma∑\\underline{P} = \\underline{P} (0) . The five-dimensional time-space-spin had been quantized as a non-dot model basic cell, the lowest energy state vertical polarized left spin 1/2 neutrino and right spin 1/2 antineutrino are just the left, right advance unit quanta _{0}nuυ, nuυ _{0} and left, right back unit quanta (0) nuυ, nuυ (0) , it again compose into spin 1 unit advance photon _{0}nuυnuυ _{0} and back (0) nuυnuυ (0) , spin 0 unit rest mass nuυ _{0}nuυ (0) and anti-mass _{0}nuυ (0) nuυ, spin 0 unit positive charge _{0}nuυnuυ (0) and negative charge nuυ _{0} (0) nuυ. It accord to the high energy physics experiment results of the transformation among the photons, masses quanta and charges quanta. The physical vacuum is the even collocation of non-combinational nuυ _{0} or _{0}nuυ. It is mathematically easy that from five-dimensional equations deduce out the Dirac, Klein-Gordan, Maxwell equations and Lorentz force formula, but appear some new results. The interactions between _{0}nuυ, nuυ _{0}, (0) nuυ, nuυ (0) , i.e., force f = ± ( h c / 2 r (3) ) r cos thetaθ for r not equal to 0 and f = 0 for r = 0, f as the magnetic force makes the photons, rest mass and charge quanta automatically come into being and stabilize. QFT no longer with divergence difficulty by the non-dot model. The explanation of abnormal magnetic moment and Lamb shift is more natural and simple only with the spin — the conjunction between turn and advance. Many testable results had been obtained. In the quantized inconsecutive time-space-spin using momentum and turn-quantity as the coordinates drawing the momentum-turn graphics are some points with certain distance. The rest mass m _{0} is the lowest energy state advance-back neutrinos pair, when j direction have 2n nuυ _{0} or nuυ (0) , the i , k directions must have (2n-1), (2n+1) nuυ _{0} or nuυ (0) for i, j, k three directions all matching into pair to eliminate the external interaction of electric quantity q (0) in nuυ _{0}. The spatial rest mass is: (n) m _{0} = (2n-1) 2n (2n+1) m (0) = 6, 60, 210, 504, 990 and 1716 m (0) . According to the uncertainty principle n large rest mass layer is more little and at the inside layer of particle. The spatial unit charge quanta e or \\underline{e} are composed by nine one-dimensional unit charge quanta _{0}nuυnuυ (0) or nuυ _{0} (0) nuυ because of the vertical polarization at each spatial direction there is only three states: the left, the right and the middle of left-right balance. With nuυ _{0} ( _{0}nuυ), e (\\underline{e}) and (n) m _{0} ((n) \\underline{m} _{0}) to constitute the muμ antineutrino, muμ neutrino, electro e (-) , and positive electro e (+) . With neutral electron ne(0) ((0) ne) as new unit compose the elementary particles masses (n) m((n) \\underline{m}) = (2n -1) 2n (2n +1) me (\\underline{m}e). The ne(0) ((0) ne) with the rest mass of electron me (\\underline{m}e). The nuυ _{0} ( _{0}nuυ), e ( \\underline{e} ) and (n) m ( (n) \\underline{m} ) to constitute the meson piπ (0) , piπ (-) , piπ (+) , K (0) , \\underline{K} (0) , K (+) , K (-) , nucleons p, \\underline{p}, n , \\underline{n}, hyperons LambdaΛ (0) ,Sigma∑ (0) , Sigma∑ (+) ,Sigma∑ (-) , XiΞ (-) , XiΞ (0) and six anti-hyperons. These particles outside layer at least has one ({2) -1} m ( ({2) -1} \\underline{m}) = 66 me (\\underline{m}e ) of piπ mesons outside layer. The nuclear force is just the direct strong interaction between _{0}nuυ, nuυ_{0}, (0) nuυ, nuυ(0) of ({2) -1}m (({2) -1}\\underline{m}) and only arises when ({2) -1}m(A) and ({2) -1}m(B) to be superposed. Though the turn-advance values U of ({2) -1}m had been counteracted, but when ({2) -1}m(A) superposes with ({2) -1}m (B) the ne(0) (A) of ({2) -1}m (A) and the ne (0) (B) of ({2) -1} m(B) can interact directly. The interaction shows as the piπ exchange force with the short-distance and saturation characters as the covalence. One nucleon has two ({2) -1}m (nuclear valences), the nuclear structure stability is dependent on the conjugation state of nuclear valences (to constitute nucleus). When two nuclear valences of all nucleons are conjugated entirely in the valences saturation state, then it is most stabilization and this element in a large natural abundance. The cubic with 4 angles, hexagon with 6 angles, double floor hexagon with 10 angles and three floor hexagon with 14 angles four kinds formation are all nuclear valences in saturation state, each angle also may be two or four particles, so that these elements: He (4) , Li, Be, B, C (12) , N (14) , O (16) , Ne (20) , Mg (24) , Si (28) , Fe (56) , Ni (58) , Ni (62) , Sn (112) ,Pb (208) are abundance, it accord to the fact. The charge q is the turn quantity U, and the mass m is absolute value of U. From \\underline{P} • \\underline{P} = 0: m (0) = e (0) = ±± (1/2 (1/2) ) (E (0) /c (2) ), q _{0} = e _{0} (nuυ _{0} (0) nuυ) = 2 (1/2) 2 e (0) = 2 (1/2) 2 q (0) . The electromagnetic (weak) interaction constant is alphaα = q _{℮} q _{℮} /h c (betaβ = q (0) q (0) /h c). The electronic outside layer is one _{0}nuυ (1 q (0) ) and one e = 9 e _{0} (nuυ _{0} (0) nuυ) = 9 q _{0}, q _{℮} = 9.5q _{0} = 19*2 (1/2) q (0) . The alphaα / betaβ = (q _{℮} (2) / h c) / (q (0) (2) /h c) = (19 *2 (1/2) ) (2) = 722. To take alphaα = 1/137.0302, then betaβ = alphaα / 722 = 1.010756*10 (-5) , alphaα is about 10 _{0}nuυ /(10 _{0}nuυ + 1359 nuυ _{0}). Because of the ne (0) of nucleon inside layer (5) m, (4) m, (3) m and in ({2) - 1} m (66 e (0) ) each one ne (0) inside layer 1350 m (0) ( (5) m _{0} + 6 (2) m _{0}) all cannot one and another superpose, the strong interaction constant g g / h c only caused by the most outside layer 19 nuυ_{0} (_{0}$nuυ), g = 66*19 q (0) and g g / h c = (1254 q (0) ) (2) / h c = (1254) (2) betaβ = 15.8943. The mass of electron e (-) and neutral electron ne (0) is me = (1 + 18 + 1350) m (0) = n m (0) , then V = m (0) c / me = c / n = c /1369 = 219 km/s. It accord to the astronomy observation absolute speed V _{0} of the solar system to rest mass m _{0} which as a reason of the electronic stabilization. In the non-artificial body the nuυ_{0 } come from the vacuum and nuυ_{0} in the balance of enter and go out body, so all nuυ_{0} moving long same direction. For m_{0} rest coordinate system, the force between two bodies is the magnetic force of two nuυ_{0} flow, but for the solar rest coordinate system it is the electric force between two charges q. For nuυ_{0} quantum, U c = e (0) c = P (0) , e = N e (0) = N P (0) / c = m V / c = m / n. The e_{0} (nuυ _{0} (0) nuυ) with one-dimensional unit electric quantity q _{0} and q _{0} = 2 (1/2) 2 q (0) , q = N q (0) = N (- q _{0} /2 (1/2) 2) = - (1/2 (1/2) 2) (m/n) (q _{0} / e (0) ) or q (2) = (m (2) / 8 n (2) ) (q _{0} (2) /e (0) (2) ) = (m (2) / 8 n (2) ) (q _{0} (2) s (0) (2) c (2) / h (2) ). Let q _{0} (2) = h c, then q (2) = (m (2) /8 n (2) ) (s (0) (2) c (3) / h ). At c = h = 1 unit system the mass unit is s (0) with length dimension. Let (s (0) (2) c (3) /h) = 1 then into C.G.S. unit system and s (0) = 6.25619 *10 ({-30) } cm. The s (0) (r (0) ) is the basic length of quantum turn-advance ism and shows the relatively intensity of gravitational interaction with strong, weak, electromagnetic interaction. In C.G.S. unit system: q = - (1/2 (1/2) 2 n ) m, f = (1/ c (2) ) (q _{1} c q _{2} c / r (2) ) = q _{1} q _{2} / r (2) = G (m _{1} m _{2} / r (2) ), G = (1/2 (1/2) 2 n ) (2) = 1/8 n (2) , n = 1369, G = 6.66964*10 (-8) . G shall change follow the galaxy absolut velocity V = c / n, which shall influence Astronomy, Astrophysics and the cosmic science especially the estimation for dark matter and dark energy. The absolute velocity and G of galaxy centrality are far less than that of solar system, which is likely the origin of Galaxies’s abnormal speed-distance curve and dark matter, dark energy. But the spectrum not change with V because of the spectrum is only determined by the alphaα (1nuυ_{0} or _{0}nuυ + 9 nuυ_{0}(0) nuυ or _{0}nuυnuυ (0) ) and independent of the G ( (n) m_{0} or (n) \\underline{m }_{0}).

List of Inspected Tank Barges and Tankships

DTIC Science & Technology

1980-01-01

C) CC’ L-4 I-I. tD w V) 8.L T 4 I-I a 0 7 z 70 70 z7 ab 2! 7.I in -9 00 M T 0 x 0 0 t0 0 t3 M wA (0 a a ty m 0 0 LA UN U 0 C3 U’N C; N; ’ ’ ’ - N C...4 0 4 4C 13&; 51 a 2I x~ -i wt W tD . w3 9 1 0& C) 1 w I U4 ox’. 94. 0: .5 It o 5A (Z it CorI.- .5L LD D w U) N-CLPp0l 0w . 0 a. ts. m5. t49- -1 0...7IL a,& 1 -j & I m 7’ en.I.1 . 4. co 4 m I f r.) ’N a, 𔃺 a, U. U. N4.’ ,sL a .4 r .47 . 󈧭u 1. X- D2 4.. a. t. x 43 N P. tD Il ’DX 03 P X tm. I V , r

Alpha List of Prime Contract Awards. Oct 91 - Sep 92. FY 92 (Chrisman Miller & Woodford - Copy Machine Store Inc)

DTIC Science & Technology

1993-01-01

zzzzz2ZZZZZZZZZZZZZZZZZZZZZZZZZZZZ Z it 0 0 1 mI coacooooccac C1 oocc 0)wmCIDmmcow m 0) coca cow0)0)m0)m0M00to)0) M0w cOD sm to M WI 00(0 a4 ZZZZZ...Coal 0 zz z zzzzzzzzzzzzzzzz zzzzzzz zzzz z If 04000 coca M MMMMMMW MmMM M it I I, Wit lina(o 11 zz z zzzzzzzzzzzzzzzz zzzzzzz zzzz z Oil I C.)OLn it...o W X: 00 10 - 4 11 no a 0000000,0000accoo 001210000 coca a Q. 11 1 <C>(,) I a .1C LJ )C < -j 11 1 < C> r) to -t (’.I (It cli 0 N N C4 N " (14 " CIJ N

All Prime Contract Awards by State or Country, Place, and Contractor, FY 88. Part 2. (Acampo, California-Loma Linda, California).

DTIC Science & Technology

1988-01-01

0 0 I 000(1 I -fN.-40)31(00 r- 00 M 00 In) 347 NO (0 In n ) U 4I0m0om I N 0 140ONN C, 0-4 0 -4 N4 0 NNO4O~ 0 00 0 I30m0om I qct o 04NŔ) 0) CON N1 C...C1400l400 -4 ce0 J-4Im o 0-4 If0U0UV000u 40 O0 l dx c c e c e ~ e d 0 x0 " -0 (DO(L -J I Mo-I I >-I-Ww(ccn~ nOWO 0 w AnD0o oo u w n0n Ln n ww , r- t- 00 w00

MIZEX (Marginal Ice Zone Experiment) 1987 SAR (Synthetic Aperture Radar) Data Summary.

DTIC Science & Technology

1988-02-01

by Messors Peter Button, Mathias Fruhwirth, Ralph Webster, Marvin Keyser, Dean Butler, Clay Atcheson, and Keith Tennant. The cooperative data...A (7 00 w m) m-- 0) m enJ. N) N1I N &lN U)) V- 1-1 ** 2 i ~0 v- 02D It P . ’i N 4 N N N ZEc . 0) 0) 0) 0) 0 c rIf Lo La U) LVi) N NN , U) ( U)I Z < C.1

The Effects of Blast Trauma (Impulse Noise) on Hearing: A Parametric Study

DTIC Science & Technology

1988-07-22

8217 q 2~~L m AALLA LAN LALALA v O 0- N( N N r4OD r: el LAr:r: v) 0n n LALALAL LAn LA vLnLA LAL LO 55 0 w * . . * 0 * * * * 0 w4 I n 4)L nL nr n nL nL nr...0ý LnLn LLLA r-in toN fLn Ln oA LA(n C.* * . . . * 10 C0 -. ~~0, NN m- AULA v *- r4~~~ ~- -1 H~i-r -4C (’eN r4* ntni L Len LAo mS- rLAn f m 04 0D LAAALL...C r-: 4 ýr- r- r-o8*i c oG o - G D% vooi %Vr- r- -4 ’-4 ( DE 0n u) tn A tn r- gn Ln .An inLn .n c4 0) 91 * . . ** Nn * LAn’Ln~ Ln to~ uiL . n nL n 040

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 2 (Allied Supply Co Inc-Ashley Machine & Tool Co)

DTIC Science & Technology

1990-01-01

I M1.-NII 0i0 0 0Q 00 0 0000000 0 UrO I 00..4N0 it 0> 00 0> 0> 00DC 4 > 0a(0 0 000000000 0 U 0)-4N KfC 0 00 0 00C 00 00000000 00 000 0 a m -4N0 C1 M...0 IN In 1 1( II< 00 o0 oCUo)_ In Infin nIn 00Co00> 0 Olin in CL if - I Cow< I CI0) 0CC 00 4n R ’D 0 NI N N oIn In inin in 0> -4r-- cn WIf 0 1C o i

DOD 1985 World Magnetic Model; Charts and Grid Values.

DTIC Science & Technology

1987-11-01

N0- 73l InD (’t- 0 7W 41.0 00 WI, .0~~o NM P-3 OOW .0 03 NWT 3"M t-o’ 0-W 01 zAW C);IWWI IN IN 1 N a- 1 .~ . .I N N N -W II WI TI 1 01 WIg mI 1 I. r. N...C4 1-A Mo 0’:0. MM 1 4 . f-.0 104 NO; A Z Ny A. 41 MM cp A Non N0 0.4 00 tun , NW * N 010 NM 03 ON a, -A 0 0 N l. W 010 41.0 3.0 Z 34L1 M :;it DO SM o

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, Fiscal Year 1987. Part 19. United Ameritec Corporation-Waste Management, Incorporated.

DTIC Science & Technology

1987-01-01

MCovvvvvv- 01 00 z0 464 I1 Ip --I-I-- - W r- W I-. 148 on JU 01in M M00()MM M O CIC’)0 64 C’I~t W t "at t I. V 1..0 1.1.0 Ia.0 u. 0 Wa000000000...q -4 M wOD..i~v .. ~y.~~ ’.p oo ao a) -0p 0 C" I I M n ID" "Im0mfn -0 m3 C4 M w (X) (0 to 430004 03CN U S I N I9 I--- -C 203o IP -. 43(000’ in3 ini...4 4 4 4 4 00 I 00 -4 N 0 0C) 4 fl ininr -40 0 -4"D 40 so0C.4 00 000 CCtN(4 0 -I 00 P- 0 0 44M C4 Nco Oc) IP -4 a*0 M’ r- r) 0 v " 0 -4 40 0-40U0 M4 NN

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 14 (Markel Corporation-Odkro Mountain Optech Inc)

DTIC Science & Technology

1990-01-01

4-4 -- 40 -NN04OC4 Ř-f CI () I 0-4- 00 a cf-E40>-4 -4 -4 -400 D0 0a0CD0 00---4.40-0 ) so I Com ’ 11 00 0027)00 a F C 0 0 )00 0 00 CO)0)000)0a)000Y 0...to )000 COM M 00)m 0)00)0 M) 4 03 0 0I(a It 2 2222 Z 2 ZZ 2222 Z 2 2 Z 1 aLn 10 0> 0> 0 0L I jz0 rL) f W N CfI 00CC040 4 N 0-4 IIMO U) L))))C 030 M11...I-m ONO 00 00.C>< -401 - I < 4 Ill 1 1 1 1 1-ltf H4 9 .4 0 (0) (0 ("n-5 Inew .)>(i : "N . .NN .NNNNNN) ON! .mnN0"NNN 04T Com 0.-4 om ~4 U wOlN0 0 0 0

Prime Contract Awards Alphabetically by Contractor, By State or Country, and Place, FY 84. Part 7. (Kwik Serv Foods, Inc. - Miller Franklin, Inc).

DTIC Science & Technology

1984-01-01

00-- - -- -- 0- a- - o OD-- 0----- 𔃺 N’K fKK) a0 -’ NN NN NN N N1 N1 01 000 NY NNNNNN- NY 0DC ci N 0O0 S 0 ID~i i 0 CDJ 0Y 0 K)) K)1 )C C 9 V 00 00...000000001-1- m IM04(i 000000000000 - - a 90)000)0 N1 NNNNNND~O - CL i 00<: 000000) 0) m N NNNN1-Y 0) 00000001-1- N W,00ɠWomoommomom v00 N NNNN C0 0000000 do...zoon Z000000 C . - CL 0 (L00 Cr.NK)0-q I-N ( .0 0C 0-0 0 >-OOOC nooNoo- EO N)~~ 0- m ONv’ N1 ) If)- toK 000- CDD- CO l I)(1 V)K0F NNCD V t 0 0 ECZ 1 0

All Prime Contract Awards by State or Country, Place and Contractor. Part 3. (Lemon Grove, California-San Bruno, California)

DTIC Science & Technology

1989-01-01

NNJ Ql B 0- 4yo if 0(( 4 I 0. -4 (71 11 I 0-400M1U c) M-0(1 0 00c 0 0> 0 00 00Q 00 000 Q II -40041 0> 00 0 0> 0 00 c 00 00 00 0 0 O--1NA it N NNP, N N...a oil I Cc01 l4 4 02 I-4 4 04 wt l i 4V oil I -4cO’ it 0 co n 4. N -4 Qs 0 00 m 0r 4Yo -,C4-ti 0J11 41(< m 1100-4 4a’ C-000 - ON0 (1-0 * 0 -4 4(0 C4

NRL 324-cu m Chamber Pressurization Experiment: Pressurant Concentration Histories with and without Obstacles to Flow.

DTIC Science & Technology

1982-03-15

N N N N N NN N, .0 . . . .en ~ ~ ~ ~ ~ ,’, m Nom N5%N5% 05% a,,O. 5 5 f5 070)5 - - - 00%0’. 0550 7% % 5’~ 5 0 5 5%5%55%00 5%. 5 0 55%5%% 55%55%55%5...O NOM N O O@0 ~ ~ ~ ~ ~ ~ ~ . aMO O O 00 0N UO0 I’foJV~~~~fl~~~. 1 @0 *N WN N MM -allWO OO V WV W Cl 0 16 - ON Wi.O~miNO 00 OM MNN 0NO N M N3M STONE...020 .03? .055 .059 .075 .041 .050 .065 .032 .050 .067 .55 .650 .039 .013 .02? .046 .050 .063 .032 .030 .064 .039 .056 .056 .60 . 043 .026 .014 .021 .036

Atlantic and Mediterranean Tables of Communication Station Azimuths and LORAN-C Station Azimuths and Distances.

DTIC Science & Technology

1979-11-01

4441* .411(( ..*4.6** 00 00 11 (C) 0941 , o c01 M 0 m a 9C N444** coo*4 *44 * *4p4 0C m m . LOC - .8 *410.4 1-12 "N*4 ".-1 1* 0.1-8(1. " - a 01...4r Zfl -1 1 -1 .N 0 0 O ’oC . - T ~ ~ ~ ~ ~ N N P.Pl rw r 4p -- -D- -ccgo Q --(. 0-o - - - . cc0 00 Go~ ~ o0t GDC 0a r- N.*Or I*OI- o."~ aL~04 0 YNV

[Results of conservative surgery in T1 breast carcinoma. Our experience in 66 treated cases].

PubMed

Barillari, P; Leuzzi, R; Nardi, M; Cerasi, A; Calcaterra, D; Cesareo, S; Brandimarte, A; Manetti, G; Bovino, A; Sammartino, P

1994-11-01

Between 1989 and 1991, 66 women affected by breast cancer smaller than 2 cm in diameter, were treated with conservative procedure plus radiotherapy. Conservative procedure consisted in quadrantectomy and axillary dissection of the 3 axillary nodes levels. Neoplasms were grouped according to TNM classification. Eleven were classified as Tis, 9 as T1aN0M0, 12 as T1bN0M0, one case T1bN1M0, 24 as T1cN0M0 and finally 9 as T1cN1M0. Actuarial 5-year survival rate was related to TNM. It has been reported to be 100% in Tis and T1aN0M0 neoplasms; 91.7% in pT1bN0M0 tumors, 95.8% in pT1cN0M0 neoplasms, 55.6% in patients affected with pT1cN1M0 tumors. According to the relationship between receptor status of the neoplasm and survival, this was 88.9% in ER+ and 77.8% in ER- tumors, and 97.1% against 71.4% (p < 0.05) in PR+ and PR- neoplasms respectively. Two patients presented (3%) local recurrence which were treated by means of a tumorectomy and radiotherapy. Both patients are still living and disease free after 6 and 9 months from re-operation.

All Prime Contract Awards by State or Country, Place, and Contractor, FY 84. Part 7 (Aberdeen, Maryland - Wrentham, Massachusetts).

DTIC Science & Technology

1984-01-01

0 C D CaDOC 00 CD001 00 0001 CD0DD 0 00ac 0C D DC 00 00 0D000000 Li wi W z LU~ wi 2: Li Li w Li Li 010t - 0a ca 0 0a o 0 0o to m 0n 0 GaO -a r NN 00...0 0N0 -C) ’ N J0 󈧄-m-3m (fl (a) (N0I- c))0- * ~ c 0 ’a I ~ 0 00 -1 -.1 -1 -j 0 000L000 00 00 I 0 (0)-1 CuaC fr aCD L z 0 Ca CD C 0 0 0 0 GaO -a C3...L ,0, O O 0 U’in) Jini t 30 OD0N Of N MN cr V)() វI 1 (D .0 >- 0 ) W - D~ Di 0- 0y >wO 0 000 c- coNC- C- Q)- - - ZN 0M F-N 1-- 9-OI - 0 - 0 - a0

Office-Based Autologous Fat Injection Laryngoplasty for Glottic Insufficiency in Patients Under 50 Years Old.

PubMed

Hu, Hao-Chun; Hung, Yi-Ting; Lin, Shu-Yi; Tung, Tao-Hsin; Chang, Shyue-Yih

2018-04-17

We sought to determine the outcomes of office-based autologous fat injection laryngoplasty in the treatment of patients under 50 years old with glottic insufficiency but without neurological problems or acquired organic lesions in the vocal fold. We conducted a retrospective chart review of consecutive patients under 50 years of age who underwent office-based autologous fat injection laryngoplasty for glottic insufficiency. None of the patients presented neurological problems or acquired organic lesions in the vocal fold. Videolaryngostroboscopic data, objective voice assessment, perceptual measurements of vocal quality, and subjective ratings of voice quality were evaluated before and after treatment. The 23 patients (7 men and 16 women) in this study presented significant improvements in phonatory function in terms of maximum phonation time, jitter, grade, asthenia, and Voice Handicap Index-10 (VHI-10) values at 3 months. Significant improvements in terms of jitter, noise-to-harmonic ratio, grade, roughness, breathiness, asthenia, and the VHI-10 values were also observed at 6 months. Glottic insufficiency in younger patients without neurological problems or acquired organic lesions in the vocal fold can be treated effectively using office-based autologous fat injection laryngoplasty. Significant improvements in phonatory function were observed even 6 months after surgery. Copyright © 2018 The Voice Foundation. Published by Elsevier Inc. All rights reserved.

Factors associated with voice therapy outcomes in the treatment of presbyphonia.

PubMed

Mau, Ted; Jacobson, Barbara H; Garrett, C Gaelyn

2010-06-01

Age, vocal fold atrophy, glottic closure pattern, and the burden of medical problems are associated with voice therapy outcomes for presbyphonia. Retrospective. Records of patients seen over a 3-year period at a voice center were screened. Inclusion criteria consisted of age over 55 years, primary complaint of hoarseness, presence of vocal fold atrophy on examination, and absence of laryngeal or neurological pathology. Videostroboscopic examinations on initial presentation were reviewed. Voice therapy outcomes were assessed with the American Speech-Language-Hearing Association National Outcomes Measurement System scale. Statistical analysis was performed with Spearman rank correlation and chi(2) tests. Sixty-seven patients were included in the study. Of the patients, 85% demonstrated improvement with voice therapy. The most common type of glottic closure consisted of a slit gap. Gender or age had no effect on voice therapy outcomes. Larger glottic gaps on initial stroboscopy examination and more pronounced vocal fold atrophy were weakly correlated with less improvement from voice therapy. A weak correlation was also found between the number of chronic medical conditions and poorer outcomes from voice therapy. The degree of clinician-determined improvement in vocal function from voice therapy is independent of patient age but is influenced by the degree of vocal fold atrophy, glottic closure pattern, and the patient's burden of medical problems.

Prime Contractors with Awards over $25,000 by Name, Location, and Contract Number. Part 1 (102 Construction Inc, Oklahoma City, Oklahoma -- Billfish Inc, Los Angeles, California), FY1991

DTIC Science & Technology

1991-01-01

Da 0 ax 0.4, 000 acca C.- C.)6 NC Lnd6 O6 N0600- c r L oC~ n 6 - - n l NY m4 0 -4C LO -6 C D 0 𔃺 o, Lc (n - - -06 o lu . CO 60 ~ 0H0,1 (v( C0C(Jm >C...L) L 0 0 -0 V 0) 4. u 040.M C> .-C -5 -5 to F6 0(2~f (k).- I C - N3 1 0 :3. 0fH- WEO .4 C.4 jL I m0 N.-. 00 ’-0 0 . CC VN L. (2 CaI 0 m c 0 LL z 9 L

Characterization of biofilms in biliary stents and potential factors involved in occlusion.

PubMed

Vaishnavi, Chetana; Samanta, Jayanta; Kochhar, Rakesh

2018-01-07

To quantify the components in biofilms and analyze the predisposing factors involved in occlusion of biliary stents. In a prospective study conducted from April 2011 to March 2014 at a tertiary care hospital, all consecutive patients who required endoscopic biliary stent exchange/removal were included. Etiology of the biliary disease was diagnosed by imaging, cytology and on follow-up. Clinical details of patients with biliary stent retrieval were noted. All extracted stents were collected in sterile containers and immediately processed for quantification of biofilm proteins and polysaccharides. Molecular identification of commonly known and unknown bacteria was performed by polymerase chain reaction and density gradient gel electrophoresis methods. Eighty one patients (41 males) with age range of 20-86 years were studied. The underlying causes for stent insertion were bile duct stones ( n = 46; 56.8%) benign stricture ( n = 29; 35.8%) and malignancy ( n = 6; 7.4%) with cholangitis in 50 (61.7%) patients. The retrieved stent sizes were 7 Fr ( n = 62; 76.5%) and 10 Fr ( n = 19; 23.5%) with 65 days median insertion duration. Polybacterial consortia were detected in 90.1% of the stents. The most common bacteria identified by polymerase chain reaction alone and/or sequencing were Pseudomonas ( n = 38), Citrobacter ( n = 23), Klebsiella ( n = 22), Staphylococcus ( n = 20), Serratia ( n = 16), Escherichia coli ( n = 14), Streptococcus ( n = 13), Enterococcus ( n = 13), Aeromonas ( n = 12), Proteus ( n = 10) and Enterobacter ( n = 9). Protein concentration according to gender (0.547 ± 0.242 mg/mL vs 0.458 ± 0.259 mg/mL; P = 0.115) as well as age > 60 years and < 60 years (0.468 ± 0.295 mg/mL vs 0.386 ± 0.238 mg/mL; P = 0.205) was non-significant. However, polysaccharide concentration was significant both according to gender (0.052 ± 0.021 mg/mL vs 0.049 ± 0.016 mg/mL; P < 0.0001) and age (0.051 ± 0.026 mg/mL vs 0.038 ± 0.016 mg/mL; P < 0.011). Protein concentration in the biofilm was significantly higher (0.555 ± 0.225 mg/mL vs 0.419 ± 0.276 mg/mL; P = 0.018) in patients with cholangitis, lower (0.356 ± 0.252 mg/mL vs 0.541 ± 0.238 mg/mL; P = 0.005) in the 10 Fr group than the 7 Fr group, and significantly higher (0.609 ± 0.240 mg/mL vs 0.476 ± 0.251 mg/mL; P = 0.060) in stents of ≥ 6 mo of indwelling time. However presence/absence of cholangitis, size of stent, indication of stent insertion and indwelling time did not affect the quantity of polysaccharide concentration. Plastic stents retrieved from patients with biliary tract disease showed polymicrobial organisms with higher protein content among patients with cholangitis and those with smaller diameter stents. Longer indwelling duration had more biofilm formation.

Characterization of biofilms in biliary stents and potential factors involved in occlusion

PubMed Central

Vaishnavi, Chetana; Samanta, Jayanta; Kochhar, Rakesh

2018-01-01

AIM To quantify the components in biofilms and analyze the predisposing factors involved in occlusion of biliary stents. METHODS In a prospective study conducted from April 2011 to March 2014 at a tertiary care hospital, all consecutive patients who required endoscopic biliary stent exchange/removal were included. Etiology of the biliary disease was diagnosed by imaging, cytology and on follow-up. Clinical details of patients with biliary stent retrieval were noted. All extracted stents were collected in sterile containers and immediately processed for quantification of biofilm proteins and polysaccharides. Molecular identification of commonly known and unknown bacteria was performed by polymerase chain reaction and density gradient gel electrophoresis methods. RESULTS Eighty one patients (41 males) with age range of 20-86 years were studied. The underlying causes for stent insertion were bile duct stones (n = 46; 56.8%) benign stricture (n = 29; 35.8%) and malignancy (n = 6; 7.4%) with cholangitis in 50 (61.7%) patients. The retrieved stent sizes were 7 Fr (n = 62; 76.5%) and 10 Fr (n = 19; 23.5%) with 65 days median insertion duration. Polybacterial consortia were detected in 90.1% of the stents. The most common bacteria identified by polymerase chain reaction alone and/or sequencing were Pseudomonas (n = 38), Citrobacter (n = 23), Klebsiella (n = 22), Staphylococcus (n = 20), Serratia (n = 16), Escherichia coli (n = 14), Streptococcus (n = 13), Enterococcus (n = 13), Aeromonas (n = 12), Proteus (n = 10) and Enterobacter (n = 9). Protein concentration according to gender (0.547 ± 0.242 mg/mL vs 0.458 ± 0.259 mg/mL; P = 0.115) as well as age > 60 years and < 60 years (0.468 ± 0.295 mg/mL vs 0.386 ± 0.238 mg/mL; P = 0.205) was non-significant. However, polysaccharide concentration was significant both according to gender (0.052 ± 0.021 mg/mL vs 0.049 ± 0.016 mg/mL; P < 0.0001) and age (0.051 ± 0.026 mg/mL vs 0.038 ± 0.016 mg/mL; P < 0.011). Protein concentration in the biofilm was significantly higher (0.555 ± 0.225 mg/mL vs 0.419 ± 0.276 mg/mL; P = 0.018) in patients with cholangitis, lower (0.356 ± 0.252 mg/mL vs 0.541 ± 0.238 mg/mL; P = 0.005) in the 10 Fr group than the 7 Fr group, and significantly higher (0.609 ± 0.240 mg/mL vs 0.476 ± 0.251 mg/mL; P = 0.060) in stents of ≥ 6 mo of indwelling time. However presence/absence of cholangitis, size of stent, indication of stent insertion and indwelling time did not affect the quantity of polysaccharide concentration. CONCLUSION Plastic stents retrieved from patients with biliary tract disease showed polymicrobial organisms with higher protein content among patients with cholangitis and those with smaller diameter stents. Longer indwelling duration had more biofilm formation. PMID:29358888

Prolonged Preservation of Human Platelets for Combat Casualty Care.

DTIC Science & Technology

1994-04-15

membrane fluidity. 5) Flurbiprofen : Flurbiprofen is an inhibitor of the cyclooxygenase enzyme and thus blocks this arm of the arachidonic acid cascade...were previously demonstrated individually to effectively block agonist stimulated activation. These agents are quinacrine, flurbiprofen and...1 0 02 1 Quinacrine 0 0 25 13 0 67 28 5nM 0 25 38 0 67 56 50nM 0 25 37 0 44 61 .5M 0 6 25 0 38 28 Flurbiprofen 0 0 6 0 0 63 13 10nM 0 6 0 0 56 19 .lM

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, Fiscal Year 1985. Part 5 (Columbia Asphalt & Gravel Inc - Dela Tek Inc).

DTIC Science & Technology

1985-01-01

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Subcontracting Opportunities with DoD Major Prime Contractors

DTIC Science & Technology

1991-01-01

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Alpha List of Prime Contract Awards. Oct 92-Sep 93. FY93. (1079 Construction Corp - American Technology Corp.). Part 1

DTIC Science & Technology

1994-03-01

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Air Force Office of Scientific Research Technical Report Summaries.

DTIC Science & Technology

1992-01-01

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M-X Environmental Technical Report. Socioeconomic Impact Estimates for Eureka County, Nevada. Detailed Tables.

DTIC Science & Technology

1980-12-22

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All Prime Contract Awards by State or Country, Place, and Contractor, FY 85. Part 4 (Sandia, California - Yuba City, California).

DTIC Science & Technology

1985-01-01

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Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 4. (Campbell and Parts Engineers-Comstron Corporation)

DTIC Science & Technology

1989-01-01

0 -l W( I * 0 0 ( < 5 ZZZZZZZ ZZZZZZZZZZZZaZaZaaZaZZZZ00ZaZZZ (.u -4 1 NNNNNNJNNNNN N N NNN NNN N NNN N NNN1 4N NNN IN NNNN N 111 U-40 1 NNNNI -NNN...qf4L) 1 m mmmmmmmmm mmmmmm OMMIXM m ca m Do mm 55 -4(,)(01 oI 000o0 0 0 00o0 000000aoa0 0 00 00 0 0o 000 0 00000000 ’ 5 0 -4-! -4 - 4 0 4- 40 4o-40 4-440...4-4-4 -4-14 14-14 - 4- --4N NN4 4-4N(’J (14 C4-.4C4 I N N -4N " J-4N-4N’.Ji (t4 01 L) -* 1 0 LA-000WUL-000~-J4z00 4

Overground Excess Sound Attenuation (ESA). Volume 1. Experimental Study for Flat Grassy Terrains.

DTIC Science & Technology

1987-06-01

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Fire Management/Suppression Systems/Concepts Relating to Aircraft Cabin Fire Safety.

DTIC Science & Technology

1982-07-01

polyamide- cm; cell size, cm; paper honeycomb; paper honeycomb; density, kg/cm 3 ; filler 2.413;0.31; 48.06; 2.413;0.31; 48.06; no core filler no core...0 4’ 14 ~ 1 4 44 N4 El4 (36M -11 - 0 0 N4 8A 0o N. 0 04 0n 0m C,0 0 44 . . 000040 -t 0 0 880 -8 ,0 04 0 C, 0 C4 4-0 OD -CD0C, m. g G - C4 A - 40 a

Revised Uniform Summary of Surface Weather Observations for Vandenberg AFB, California, MSC 723930. Parts A-F

DTIC Science & Technology

1985-05-01

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Computer Assisted Medical Diagnosis (CAMD) System Version 1.0 Technical Manual.

DTIC Science & Technology

1992-10-01

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Joint High Speed Sealift (JHSS) Baseline Shaft & Strut (BSS) Model 5653-3: Series 2, Propeller Disk LDV Wake Survey; and Series 3, Stock Propeller Powering and Stern Flap Evaluation Experiments

DTIC Science & Technology

2007-09-01

B27 B3b. Open water performance characteristics, stock propellers 5234 and 5235 ................... B28 B4. Principal dimensions of...n~nu~ .. *ASA B27 B3b. Open water performance characteristics, stock propellers 5234 and 5235 5234 5235 FAMED OPEN WATER COEFFICIENTS FOR PROPELLER...LA V 00 H MN 0𔃾 LAW M 00 MN4 0 ( LA M 4. ~ ~ ~ ~ r 4. LALA (0 m N 0 0 H H- H H H Hm H H vN( N( N((((m 4 HmmN N4 L 0 .( N ( ( HW H HLA mL (n(mNHO H

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 17 (Ray Industries-Service Screw Company Inc)

DTIC Science & Technology

1990-01-01

0c) Cc) Nf 1 (04N< 11 L)(0 H.r)O) ( 61010 -40,0) 00)0) .CNNNNNNNN L. 0 *-e) N I(.4N< Il0001 11 ) CYO tnc(yc >0(3c i~ CY CYCFCYacaaaaCV o or( .mCY.. I...0 - 1 W- 0 I- 9XN 1n L 0- 9 N o it ICO M-4 (0 2- 0 .c 0 w -j Z F-11011= C’. 114 Z z0 0 0 Q -1 0 x wJ w 0 IEC M-4 0t LU4 0 0 0 0-q 4-C) 1-- 0 -4(0- oo...C’, N " NN 0 N MM~tN-04 to N~ -4 C0 (0) 0 (0(0 N Nl MI en0 10)00-4-40 0 -4 0 C00 0 -1 00 -4 -4 Mf~ Iec ’ II-00(0(00o 0 (0) 0 00 0 0(0 000 47) (0 all

Characterization of diadenosine tetraphosphate (Ap4A) binding sites in cultured chromaffin cells: evidence for a P2y site.

PubMed Central

Pintor, J.; Torres, M.; Castro, E.; Miras-Portugal, M. T.

1991-01-01

1. Diadenosine tetraphosphate (Ap4A) a dinucleotide, which is stored in secretory granules, presents two types of high affinity binding sites in chromaffin cells. A Kd value of 8 +/- 0.65 x 10(-11) M and Bmax value of 5420 +/- 450 sites per cell were obtained for the high affinity binding site. A Kd value of 5.6 +/- 0.53 x 10(-9) M and a Bmax value close to 70,000 sites per cell were obtained for the second binding site with high affinity. 2. The diadenosine polyphosphates, Ap3A, Ap4A, Ap5A and Ap6A, displaced [3H]-Ap4A from the two binding sites, the Ki values being 1.0 nM, 0.013 nM, 0.013 nM and 0.013 nM for the very high affinity binding site and 0.5 microM, 0.13 microM, 0.062 microM and 0.75 microM for the second binding site. 3. The ATP analogues displaced [3H]-Ap4A with the potency order of the P2y receptors, adenosine 5'-O-(2 thiodiphosphate) (ADP-beta-S) greater than 5'-adenylyl imidodiphosphate (AMP-PNP) greater than alpha, beta-methylene ATP (alpha, beta-MeATP), in both binding sites. The Ki values were respectively 0.075 nM, 0.2 nM and 0.75 nM for the very high affinity binding site and 0.125 microM, 0.5 microM and 0.9 microM for the second binding site. PMID:1912985

Diagnostic modeling of dimethylsulfide production in coastal water west of the Antarctic Peninsula

NASA Technical Reports Server (NTRS)

Hermann, Maria; Najjar, Raymond G.; Neeley, Aimee R.; Vila-Costa, Maria; Dacey, John W. H.; DiTullio, Giacomo, R.; Kieber, David J.; Kiene, Ronald P.; Matrai, Patricia A.; Simo, Rafel;

Prime Contract Awards Alphabetically by Contractor, State or Country, and Place. Part 8 (Giordano Associates Inc, Long Branch, New Jersey - Hewlett Packard Company, Cupertino, California), FY1991

DTIC Science & Technology

1991-01-01

0F- CDin in V0 55 I (0-I U 41000* 0- F-3-r 4 - InIL. Ln f4 F-LLI-4.-4f-F- ". U 0L I M-4 U 4-I0 F- F-4 04 InU.4c 04 = O w I4n400... 4 : (0-4 U W- InIIL...1cI- I.- F- I.- 0D I- I- hi I M i-4 a 2( 20 O 20 ZOCCCOOOOOOOO 0 zOWWQDQDCOOOOOI U3 1 S i-4 55 c% WN"h4 W -4 w - 4 MCMrM)M.MCM)M’M-4 4 4 4 hi -4 hi-4-4...0 0 00 0 0 00 0 0 00 0 0 M- 55 i-4 II mm ic x x xx xx x (n NI in4 N -400 -40CD -440 -4 00 0 00 C 0 00 0 0 0 000 .4ɚ 0aC 4 D0 00 000 4N S n0-I K 000A

Alpha List of Prime Contract Awards. Oct 92-Sep 93. FY93. (HSU Ronald Construction Co. - Jacobson & Son Yard Service). Part 10

DTIC Science & Technology

1994-03-01

WCo toJ Il I OOt 0 CL I I 004*LaJ 11 On 11W 00t) II o4 4 4 4 4 ov4 44 4 4 4 444 44 If 00’E01 M൴ 44 44 114 COM it L)UUUUNN 440 4000000 00. NON NI N44...N E I-I 1 0CDO II-.00-40000000 0000000-. 000-. 00 00040 0-.40 U:1-0C)C V V f)0C)mMC v V mI M M0V II CNNN Nr)NMC) YC V ) N NV4 C)M Y MmM Mm0il I Com 2...4- --N4-4 -4.MM-4 -4.ý -4 11 100I 00 P (0.-00iNDOmr. -QDO coM L i i i i i iN i(D 00L0 D(D i(00000MM NM Mr fMMr. M 0MMr.%WO 0W 0aW 11 -4 (0 0 II-cj 1 a

Revised Height/Weight Sizing Programs for Men’s Protective Flight Garments

DTIC Science & Technology

1979-04-01

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Bioassay-comparison of the antioxidant efficacy of hydrogen sulfide and superoxide dismutase in isolated arteries and veins.

PubMed

Hamar, J; Solymár, M; Tanai, E; Cseplo, P; Springo, Zs; Berta, G; Debreceni, B; Koller, Akos

2012-12-01

Recent studies suggest that hydrogen sulfide (H2S) exhibits potent antioxidant capacity and improves vascular and tissue functions. Thus we aimed to compare the antioxidant efficacy of H2S to that of superoxide dismutase (SOD).Isometric force of isolated rat carotid arteries and gracilis veins was measured with a myograph. The vasomotor effect of the superoxide-generator pyrogallol (10-5M) was obtained in control conditions, and then in the presence of SOD (120 U/ml) or H2S (10-5M or 10-4M), respectively. Spectrophotometric measurements were performed to detect the effect of SOD and H2S on the auto-oxidation of pyrogallol.Pyrogallol increased the isometric force of carotid arteries (9.7 ± 0.8 mN), which was abolished by SOD (5.3 ± 0.8 mN), was not affected by 10-5M H2S (9.1 ± 0.5 mN), whereas 10-4M H2S slightly, but significantly reduced it (8.1 ± 0.7 mN). Pyrogallol significantly increased the isometric force of gracilis veins (1.3 ± 0.2 mN), which was abolished by SOD (0.9 ± 0.2 mN), whereas 10-5M (1.3 ± 0.2 mN), or 10-4M H2S (1.2 ± 0.2 mN) did not affect it. Pyrogallol-induced superoxide production was measured by a spectrophotometer (A420 = 0.19 ± 0.0). SOD reduced absorbance (A420 = 0.02 ± 0.0), whereas 10-5M H2S did not (A420 = 0.18 ± 0.0) and 10-4M H2S slightly reduced it (A420 = 0.15 ± 0.0).These data suggest that H2S is a less effective vascular antioxidant than SOD. We propose that the previously described beneficial effects of H2S are unlikely to be related to its direct effect on superoxide.

Neonatal and maternal serum creatinine levels during the early postnatal period in preterm and term infants.

PubMed

Go, Hayato; Momoi, Nobuo; Kashiwabara, Nozomi; Haneda, Kentaro; Chishiki, Mina; Imamura, Takashi; Sato, Maki; Goto, Aya; Kawasaki, Yukihiko; Hosoya, Mitsuaki

2018-01-01

We investigated the relationship of neonatal and maternal serum creatinine (nSCr and mSCr, respectively) with various maternal/infant characteristics at different gestational ages (GA). We reviewed medical records of neonates admitted to NICU. We collected data on birth weight, GA, Apgar scores, medications, etc. Spearman's test was used to analyze the correlation between serum creatinine and continuous variables, and the Mann-Whitney U and Kruskal-Wallis tests for continuous variables between groups. The changes in nSCr, mSCr, and nSCr/mSCr ratio because of gestational age and the points in gestational changes in trends were estimated using joinpoint trend analysis. From 614 neonate and mother pairs, we found that nSCr was significantly correlated with GA. However, mSCr at >28 wks decreased with GA. The nSCr/mSCr ratio was correlated with GA. In infants born <29 weeks, pregnancy-induced hypertension (PIH) (p = 0.000, β = 0.20) and mSCr (p = 0.000, β = 0.73) were significantly associated with nSCr. In term infants, maternal magnesium administration (p = 0.000, β = 0.25), respiratory distress syndrome (p = 0.013, β = 0.16), PIH (p = 0.005, β = 0.19), and mSCr (p = 0.000, β = 0.33) were significantly associated with nSCr. nSCr reflected mSCr at all gestational ages. The correlation between nSCr and mSCr in preterm infants (p = 0.000, β = 0.74) was stronger than in term infants (p = 0.000, β = 0.34).

Comparison of Different Cuff Pressure Use with the Supreme Laryngeal Mask Airway on Haemodynamic Response, Seal Pressure and Postoperative Adverse Events: A Prospective Randomized Study.

PubMed

Ali, Achmet; Altun, Demet; Sivrikoz, Nukhet; Yornuk, Mesut; Turgut, Namigar; Akıncı, İbrahim Özkan

2018-04-01

The Supreme™ laryngeal mask airway (SLMA) is a supra glottic airway (SGA) device that is used as an alternative to endotracheal tubes. In the present study, we aimed to compare the use of the SLMA with normal cuff pressure and low cuff pressure, primarily for haemodynamic response. In the present study, 120 patients diagnosed with hypertension and scheduled for varicose vein or inguinal hernia operation were enrolled and 99 patients finished. Using randomization, patients were divided into two groups according to cuff pressure as a low-pressure group (Group L, 45 cm H 2 O) and a normal-pressure group (Group N, 60 cm H 2 O). Demographics, Mallampati score and the type and duration of surgery, heart rate (HR), mean arterial pressure (MAP), percentage of tidal volume leakage, Ppeak, Pmean, etCO 2 , seal pressure, fibreoptic scores and postoperative adverse effects of all patients were recorded. MAP and HR values immediately and 2 minutes after SLMA insertion were significantly lower in Group L (p<0.001). In Group L and Group N, the seal pressures were 24.1±3.1 cm H 2 O and 26.2±3.9 cm H 2 O, respectively (p=0.003). Also, blood staining and sore throat occurred less frequently in Group L (p<0.05). The fibreoptic average score, insertion features and ventilation parameters were similar between the groups (p>0.05). SLMA use with a cuff pressure of 45 cm H 2 O significantly decreases haemodynamic response and post-operative side effects compared with a normal cuff pressure. Therefore, except for some specific surgeries that require higher seal pressures, we recommend the use of the SLMA with cuff pressures as low as 45 cm H 2 O.

Dollar Summary of Prime Contract Awards by State, County, Contractor and Place. Part 2 (Alachua-Menominee)

DTIC Science & Technology

1990-01-01

0c -4 -40)4- * L Iit m * 40 404 CD to I 4 0)0m (a 04) a~ CV -1*c 𔃾 I4 C)II tun I nco -4 0V) C) m 0 01~~~~~e CO I ON N000 N0l I2I4 N 0 CO In 40) - 0 0...WO a.I-1W z o -0z zw1- " WWM4- oo mx04C’)4Ua Ŕ(1~f 0004-NBaN’a004’N004-4-0Z flC’ Wa K- ) II= 0 I N a N(𔃻P- zAw ~ 0 -aQfl4-4N 0 a -00(’)0t7- N ofa a0

Geographic List of Prime Contract Awards. Oct 91 - Sep 92. FY92. (Bridgeville Delaware - Key Biscayne)

DTIC Science & Technology

1993-01-01

N (4-1 r4 N1 + not I Ooc’) i1t z 0 0)0)toooooo 0)0 GAO )()(7 )0() 00) to Z a) 0) C) () tooott (7 )0)00 at o IMO "N Ito UA 𔃾C < 1 MtON 8(4 4f o 8-4 Q...0) 1 DOC>-* 11 to -4 C, Wac)CDC)40 0) -4 C> C> -4 0 to ýq M 0 U I MOýt of -J M 04 C1,J N CM " -IT M -4 CY) Cl) M Cn - JINI -4 -j C1) m C*4 -it RT -JC

Assessment of denitrification gaseous end-products in the soil profile under two water table management practices using repeated measures analysis.

PubMed

Elmi, Abdirashid A; Astatkie, Tess; Madramootoo, Chandra; Gordon, Robert; Burton, David

2005-01-01

The denitrification process and nitrous oxide (N2O) production in the soil profile are poorly documented because most research into denitrification has concentrated on the upper soil layer (0-0.15 m). This study, undertaken during the 1999 and 2000 growing seasons, was designed to examine the effects of water table management (WTM), nitrogen (N) application rate, and depth (0.15, 0.30, and 0.45 m) on soil denitrification end-products (N2O and N2) from a corn (Zea mays L.) field. Water table management treatments were free drainage (FD) with open drains and subirrigation (SI) with a target water table depth of 0.6 m. Fertility treatments (ammonium nitrate) were 120 kg N ha(-1) (N120) and 200 kg N ha(-1) (N200). During both growing seasons greater denitrification rates were measured in SI than in FD, particularly in the surface soil (0-0.15 m) and at the intermediate (0.15-0.30 m) soil depths under N200 treatment. Greater denitrification rates under the SI treatment, however, were not accompanied with greater N2O production. The decrease in N2O production under SI was probably caused by a more complete reduction of N2O to N2, which resulted in lower N2O to (N2O + N2) ratios. Denitrification rate, N2O production and N2O to (N2O + N2) ratios were only minimally affected by N treatments, irrespective of sampling date and soil depth. Overall, half of the denitrification occurred at the 0.15- to 0.30- and 0.30- to 0.45-m soil layers, and under SI, regardless of fertility treatment level. Consequently, sampling of the 0- to 0.15-m soil layer alone may not give an accurate estimation of denitrification losses under SI practice.

Catalog of Space Shuttle Earth Observations Handheld Photography. Space Transportation System 37 (STS-37) Mission Dates: April 5 Through 11, 1991

DTIC Science & Technology

1991-08-01

mC3* o 0 Im IOOm cy1Y C~~-3 )C) tUN o( -PNr - oG 1-4 o oGo c do oo GoO a m.w o , " 00 0OD 0 0ooom a @ a 4m0)4m4 C M m0)ahm0)cmm ao4m4 OC C N-N^A Nm " N...L303113 31393B3131 3N3131M393133 383 10 ~ ~ ~ ~ ~ ~~G 10110 0 400 (100 01100 I.- .atmza a af tz z zaW 2aU 2cM Zz za aaa aa a a cn cc Oo (0 to in 410

Carcinoma of the larynx: role of laser surgery

NASA Astrophysics Data System (ADS)

Inouye, Tetsuzo; Tanabe, Tetsuya; Nakanoboh, Manabu; Ohmae, Yukio; Ogura, Masami

1995-05-01

68 cases of glottic carcinomas (T1 53 and T2 15 cases) treated with CO2 laser or KTP/532 laser April 1982 through March 1992 were reviewed. The patients were followed up from 13 to 130 months (mean 60 months). The 3-year determinate survival rate was 100% and 5-year determinate survival rate was 100% for T1 and 80% for T2. The voice conservation rate was 97% for T1a, 83% for T1b, and 80% for T2 and vocal function was satisfactorily preserved for daily life. The results led to the following conclusions: (1) Glottic T1 carcinomas can be treated by laser surgery alone. (2) Lesions involving the anterior commissure can be treated by laser excision and vaporization. (3) Laser surgery followed by external radiation therapy for glottic T2 carcinomas improves the voice conservation rate.

Prime Contractors with Awards Over $25,000 by Name, Location, and Contract Number, Fiscal Year 87. Part 7. Kinnetic Laboratories, Incorporated-Medical Supplies Manufacturing.

DTIC Science & Technology

1987-01-01

tD -4 00...r-0N oo U) 0 ( t- OD 0 m -~0 S N 4bD ko .10,- - 0 >0 0- 4 ’I’ A-l i 0 c X: 0 to 00 -5 z9 0. c . 4! 0 0a LJ O 4 In -3.4 z 6 w- 0E *i 0 E3 T-). 6 0 0 0...CCH C CC L(U~4r)-. -ccC 13 td cc- C ~00 ~ 121-’CC~~~~A AtL C CU . . rC ~UM I;7 : m u Su ~~,- U. U -p.- N- 10 m99 90 r-- OD0 N 90> - a N m0.- No x w

Robust Multivariable Controller Design via Implicit Model-Following Methods.

DTIC Science & Technology

1983-12-01

followers, such as: II-7 , Ai ".......... . - ,. * . . , -. ,., 4’ . L7 XJ •:-, - J - / ( -+(Y -m)-- ( _ym + UTUc-]dt (11-13) A design method based on...Im r4 aI AI wS I I C.) 0 N 0N ON0N% I4 A’. I 0L- t-00 o% 0 ON 000 LA0 Naj UzN W4 c * r- In Go .% m * m . \\ C-. 0 cm a 0 ’no L- 00 *- \\ 14 0 0 ’-C Go N...0 t’. ~ - V’’. LALA -f . ONZ LA 41 0 \\ NL 0n I a A A N aI ’ nN? Z . =. 4 1 -I -0 I. I %a .0 1 - .a to. ot .b t o ob oto ob o11 cc-. "-f cccX dc c t I

All Prime Contract Awards by State or Country, Place and Contractor. Part 10. (Abington, Massachusetts-Zeeland, Michigan)

DTIC Science & Technology

1989-01-01

IOOOOON ᝰ WO) 40L L i LLJ 14 M -4 :: 347 )0( 0 ix 4(0 0.70 4z0(0) 0 0 co L(0 M00 0)L’ 00 (0.- 4 0.4 of4C 00000 IO0 00 00 00 w00 0000 0000 0’) 00 00 0000 V...82174mw-*0 N"’- -4N CO NOWO MINIM) m’,4mmw0 -400 mmC’ -4N-401U1 LA ON I 0)00 It :) C 000 If aHc CO0 a* I N. U I moo0 It IL Q M 00 (11 1 I 00- if I H4 0

Prime Contract Awards Alphabetically by Contractor, By State or Country, and Place, FY 84. Part 2. (Bay Area Controls - Cirtech Corporation).

DTIC Science & Technology

1984-01-01

AC._E All ot ter edotons are oosolete. 747 to z ’ -’ (1 0A co 0 Y N N M) ( D ) D ) () C) ftN NII C N ~ N ID 0 Iq N N Q0I ) e D0 N I-’ N 17 -0 CDN Z O...L) C ) 0 0q D C .0~ ~ ~ ~ ~ C -)0 )- C- - C- I- - C-----)- NNN- 0 w iIw w r I ca - - N NNc N N IN ’mN N NNNNidN N CC N N: N - 0 0’ L)W C YWa*i c N Y...W N’ K) c) X K x K)4 K) Y a) w0 N)~ N--4 N N- K) d K)- ---------- ) N ) N )- N CO D0 .0 0N 0 00 0 0 0 K)NNN 0) K) 0 0 0 Vi0ac.o )0 0OO N NON C) 0 0D K

Prime Contract Awards by State or Country, Place and Contractor. Part 4 (Salinas, California - Lompoc Valley, California), FY1991

DTIC Science & Technology

1991-01-01

1 L)if I M4’) 100 < of ICO 1a" 0..( crI of ) " i X I- H 011 WCN I(A z EfmE 1 3 I4 o 0f mIi I mcON I’ ~0L4C0L0O)0AIC)0’N𔃾LN-C.4)-4CCLC)4)00~C ofI z...00n Inn~~U~f Gn)fUU U o LU L) NLL a 00 4N N m oo---444444--.4- COO- - -4 4 4 4- - - - 0.o0 04o- 4M 100 NO moo0 0 j IX N11- 10000c N 4 0000 4 -ON -0)000...2j O il to N I ciI- $._ I 1-4_ J ZN 100 N13 U 11 wo x IN4 0 Na (0, 21 - 4co()0r na >c4r-I 0- o ni 7 .- - 4ɘ . D 0 0 $_r 044 81 CN NfC)0 Y o - * 4r 0

Prime Contract Awards Alphabetically by Contractor, By State or Country, and Place, FY 84. Part 4. (Eastern Car Construction Company - General Displays Company).

DTIC Science & Technology

1984-01-01

8217(-O0I0D 0 <C 4 4 00 0i)-0 N Z ( N- 10 00 *- ZO I o Q) <C W0Z -001 - 00 -0001- o j -ZO 0O0O- F- z0 CCi)00 4 - i co0 0: O (1) CL C00I De ) 0 I) -WL)C 0 0m 0...000 04440000 Iu.0 -, 0 0 0 DZIL DE CD LbLL Z D Z Z DI z 00 U IQC )()M-r q- Ml P, - (1 A -Nv -NvN 0.4 N. 0 0 )o C0nNO0n 00 L0 0-V o D-000-00ON -’ . 0 In...00000 00 NO ... OO 000 40 KO < DE ~ - -# 4c M Wi) wC - V0 00) 0)Ci) 0 0 ( 0N 0 )0)0I i N If N C) W _j O~D 10 0 x JN00 00 0-1 40 0 0 4- j <iWi- -O woo

All Prime Contract Awards by State or Country, Place, and Contractor, FY 84. Part 13 (Abingdon, Virginia - F. E. Warren AFB, Wyoming).

DTIC Science & Technology

1984-01-01

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Prime Contract Awards by State or Country, Place and Contractor. Part 9 (Dundalk, Maryland - Roseville, Michigan), FY1991

DTIC Science & Technology

1991-01-01

0 0 0 400 100 C 0 00 C* -I 04 U )L - )IN ) IL OOOOOON S. N N N N N N NN-N * L).-I.-4 zzzzz2zzzzZZ 2 Z 2 2 ZZ zzz U-I 0-m MI4444444 0 N N 00C4o<N 0NI0...1 Co-I me WL-4 -4--4-44-4 -4 -4 -4-4 -4 -4 W40 (1N 1-0 -4.1 I-aInan CL.-IC) ne me A2 I o- - 100 00.- me D.. o o 00 0 o oo0oo00o 0 &)0 A (no 40, aO o0...oln o-4)- 411 U)0. In). 10 InI n ca if d I N w ~ (D< a4C N 4 M0 3 4 0 4- I3l 44 XCi X’ c"Il _C44 a-I 0Cl M-i ’in if 100 - -2 N D 00 1- 0 1-) 1 00 1

Cat iris sphincter smooth-muscle contraction: comparison of FP-class prostaglandin analog agonist activities.

PubMed

Sharif, Najam A; Kaddour-Djebbar, Ismail; Abdel-Latif, Ata A

2008-04-01

The pharmacologic characteristics of a number of FP-class prostaglandin (PG) analogs were determined by using the cat iris sphincter smooth-muscle-contraction assay. Cumulative concentration-response curves were generated for each compound. The relative agonist potencies (EC(50)) of the compounds were: cloprostenol (0.0012 +/- 0.0004 nM) > travoprost acid (0.46 +/- 0.13 nM) = bimatoprost acid (0.99 +/- 0.19 nM) > (+/-)-fluprostenol (15.8 +/- 2.6 nM) = PGF(2alpha) (18.6 +/- 1.8 nM) > latanoprost acid (29.9 +/- 1.6 nM) > bimatoprost (140 +/- 45 nM) > S-1033 (588 +/- 39 nM) > unoprostone (UF-021; 1280 +/- 50 nM; n = 4-14). The maximum response induced by travoprost acid (122% +/- 2.3% maximum response relative to PGF(2alpha)) was significantly greater than that induced by all the other PG compounds (P < 0.001 - P < 0.02). Interestingly, the FP-receptor antagonist, AL-8810, behaved as a moderate efficacy partial agonist (EC(50) = 2140 +/- 190 nM; 63 +/- 4.3% maximum response relative to PGF(2alpha)), indicating that the cat iris contains an extremely well-coupled FP-receptor population, and/or the tissue contains an extremely high density of the FP-receptor and/or spare receptors. The cat iris contraction data were well correlated with other FP-receptor-mediated signal-transduction processes, including FP-receptor binding in bovine corpus luteum (r = 0.86), FP-receptor binding in human iris (r = 0.61), phosphoinositide (PI) hydrolysis in human ciliary muscle and trabecular meshwork cells (r = 0.77 - 0.86), PI turnover in rat and mouse cells (r = 0.73 - 0.76) and via cloned human FP-receptor (r = 0.9), and rat uterus contraction (r = 0.84). These data confirm the presence of functional FP-receptors in the cat iris sphincter, which are exquisitely well coupled and which respond to a variety of FP-class PG analogs with differing potencies.

Prime Contract Awards Alphabetically by Contractor, State or Country, and Place. Part 7 (Federal Improvement Co Inc, Virginia Beach, Virginia - Giordano Associates Inc, Robins AFB, Georgia), FY1991

DTIC Science & Technology

1991-01-01

CN 040 cOm 0 1- 00 ɘ 5.00 X0 w 1- Imn w* a 0 6 004 x -.400 N - ery 4N 0t I-NC .7-4 540 0. -m 0 C a0 n is CA IS I (0(04 If so* AO .flmfl -3115 EC) 4...0 0 0 0 0, 0 0D 0 o 0 W CU .- 00 Cm, .0m .0m .0m GoaM com caM c0m 00am cam Mcam ccaM S4W I -1 .4c P.4 l 1-4 ’ .4 <.. r.4x r -C4 r.4c r. 4 r_< . < I...x X NNX XNxX X XN X N NN W * )4.O I 0~ C7 D c aCD 200 0CDCD (9 00 10 5 5 ( 0(9 (90 D 0CDCD 9 (D(5(D D C90 ) 0C90 ( C * 0 qo U 4 4 44 4 4 4 44 4 4 4

Prime Contractors with Awards Over $25,000 by Name, Location, and Contract Number, Fiscal Year 1988. Part 7. (Mitchell E. L. Construction-Precision Roofing and Supply, Inc.).

DTIC Science & Technology

1988-01-01

C, 0)04 4ZD m 0 o A) 0)0)0, mw c ) 0C’) ALO MM kHA )A0W -LO M I C. 04 C-)A.H nm4 N,04 04C’, (N N -A4 N0.(4( tAA 4- : a 0) ) N 0 Ir 0I OD <IL)0 0 0 ,r... Zin ~9 0 09 . 9. c 0. 9a z3 0.9 90 0 9 9 0.0 m0u99 I 0.8 f., Ŝ Z9-9 0) 9 C90cc 00 0. 0)- 9 -0 9> z -0 0 � (08 0 . 9 9) n0. (0 .9X 0 00 9 90 9 𔄃 09

All Prime Contract Awards by State or Country, Place, and Contractor, FY 88. Part 10. (Acton, Massachusetts-Zeeland, Michigan).

DTIC Science & Technology

1988-01-01

4 4) . 4U o < 0 -C- En 0 -. 4 _U 0 C) 4) v) 0 EU-7 C V~-4 -4 En4 ) U 0 r o A-4 0 0 0 z -4 = , = 0 0 CDQ v " C, V EU m V) 41 h- v 0o 0 r o~r .i . E...0 -0 41 A- C w- . 4) 0~ 04 0 .4 0 - 4 L) - 4 o0 m 4-- 0 U n U 4 (/) 0 - En to > . EU 4 4 4) :3 O = >, 41 r= O = EI 0 m - A-. 4) C En z 4 . ) w4) c V...V ) - j Ch ) EU fo u L) 0. o0) oo <n 0 -) 4nV E 𔃾 U) 0 . - - ) 0 - -- co 4.- c C0 0 -4 " > q in CO - 00 0 ... C4 0N m . 4) - .- 40 0 En 0 C n EU

Domestic Base Factors, Fiscal Year 1979. Volume I.

DTIC Science & Technology

1980-03-01

z c 0 0 w. - ri Z < - I-- 4 - ,I W M) -- ;.0 W -- ɚZ X W 44 A W LL -4 (L I LL w a0 Id x2.0 W 0 CL td Wi < - W 004) IL o I i j x m. A. 1. I - 1 L...0ONVCO7 ) Q0 ’+P,* ir) eC,- 0 0 - -O,- ) 0ID m ty if) - -0 _r-- 04 N 0 N (0 td <-444 -0 IL V)C .W a " a - LL (00r c 0 0 v U 4 a-0- ILJ -i I uIL X - a z...C) z r- 0 ) 0 7 ( CD 00 0(0 (IN f- ( 0 N 0 t) Li (I., < Z -C) . CO. . LL4 < U - 0 tD (DON C 0- is, m 0) 0 0 0) I N N l F- ’C 0-- 01 NM U) CYN CD (D

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, FY 88. Part 13. (Marshall Electronics. Inc.-Monarch Crown Corp.)

DTIC Science & Technology

1988-01-01

000000a 1-0 1-00000000000 -00-4 39 w0 moon dewca00 acca QCUQ0 w9 100000000 300-4 310 if- 24ɜ IN"" IN 14 4 < 4300 w-4 34 -C- C2 44 * 4 C4 X 1000-4 130...MMC) @) N4 Ř 0 (0 ZCN NNN ON >. 1 W00O4C~ U) 0wa ccd c cO ON 444- - 44 U. I o a006. I0 6 U.w mop01. F6 m00 @0w-4 r- ,CV) N- 0 w W 90N C14 M 0) It0) N...6r- 6I.- r - f6 -6 000 0 00 -.- W004 6 -4 CV0 m mm 000000 40wo P.V-.- 0v Owlm M000 I mn 6n( )40040 P 00 000 r-0- 4 600 0 a1 .N MCC00 1 .4 ON04 N NO4

Installation Restoration Program. Phase 2. Confirmation/Quantification. Stage 1. Air Force Plant 4, Fort Worth, Texas. Volume 2. Appendix A-1.

DTIC Science & Technology

1987-12-01

N1 4. j -0 z0 Uc n 41 or tD D, C a z 4s -J’ - - -T. = 3 CL Ct UL Cfl a-4 CL c r- 0CL U 4 -40 0 CL - :r j3 :) c c 0 0.’ 0- 1- 0 j c D4 C 4) 4 M 48= u...Ii el ozi - - 1 2 1 * ~ ~ ~ ~ L I.) z T L F-, ~ ~ - - *~~~~~ ~~ 093. j ,U .) . C- i n- zi -7 CD Z- c c c c c I a D- do 0. CL C a- JaJ - LA a) IC= -=1 -4...w N M’ it ’.o r’. M O’ 0 td M ’ 3aW 0 00 0 00 0 0 .- - .4 14 LaJ4 W4V L" Z- Z C3 1=z C= CD U IS LL L W N m’ t U) M 0. 0 . ’-U> CDn I-0 00CSI-W0C S6

ESTCP Live Site Demonstrations, Massachusetts Military Reservation, Camp Edwards, MA

DTIC Science & Technology

2012-09-06

Blank 372,252.872 4,618,629.872 N/A N/A N/A T-005 Medium ISO 372,255.575 4,618,626.492 0.30 Horizontal Across Track a Positions T-001 and T-004 were...Med. ISO 1.69 1.77 1.73 0.031 0.94 1.01 0.98 0.02 0.92 0.96 0.94 0.01 S ho tp ut 15 5m m P 81 m m M M ed . I S O M ag ne tic P ol ar iz ab ili tie...Depth Error (cm) Min Max Mean RMS Shotput 0.30 1.40 1.00 0.5 155mmP -2.70 -0.90 -1.80 0.5 81mmM -3.50 -2.00 -3.00 0.4 Med. ISO 0.80 2.10 1.50 0.4

DoD Industrial Security Program

DTIC Science & Technology

1985-12-01

0 0 - a *ju .4 C4 -0a m W4 M (𔃾S P A "-f~%~vs %n P4 M NI N ’ 0 45~~~~ 0 14 fl.-a n0 P 5 4 C4N0’ 0 - 1.4 00i~inn* so6 06 0 ’.4v- C4IS mu 4 0 C...41 (a 0ie $4- P4 V10 ka. " 4 . 10 6C 00 N0%’UPCin’A445 0 It. -.W0 0 4114 uk0 4I. 0 V 3 : 5 a0 - 4; w 00 44U *% 2 -4 0 1 W 0 g *4 0 % 0 0 4-cw9: 6q V4 0 ...a 0 .bI - 0 0

Alpha List of Prime Contract Awards. Oct 92-Sep 93. FY93. (Oank8 Elbelco Inc. - Food Service Decor & Design). Part 7

DTIC Science & Technology

1994-03-01

In = 4j 1 wow 11 (A com L) w U U) 04 ý4 0 u Ce ý4 0 0 Cie 0 Ix rý 00 .4 L) cc W 0 N C I cc" If x Q-J(Doý- x q1t (D 0 xooooý-- 0 L) 0 0 ý- CL. 0 m Ln...oCGoCOCO CON CN w 4 < 0 44 < O44 M -cvMN U (COO0-40(11 .-40 -40 OCOCCID(O 040 00W 04 NU) COM -i -444 0 N 0-4 if U.. a: a Ezz Z z 0 In0 000 a CV (0() 3n U4... coM 4)(4W-4 sN UN u m 4 - W gn N I 004- If > tcI Ny.4 -4 of0 X.4 cc (a 000000000001111111111Q0 N a I 004o- N1 as 4- -40-4 .4 -4 0 No tl 00 0

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 3 (Ashley Steel Inc-Bettencourt R E Inc)

DTIC Science & Technology

1990-01-01

Jin -JIn -j In -j In -1 O -. 100 -. 1000 I,. Hf - M (-4 Hic -.1JC ~In -JO0 . JCI -J in -.i n .1(1 -i in -JO0 . .04 .J044C C)~ 11(0M-4 ’wCD w LC W0...co 10.oc *< < 04-. <g < 4 4c 4( < � in- inIB- N N NNNNNNN con 004Co 100 * I0-4C)0B00 0 000 00 0-0 00 C00000C000 0 *I-4 Cl0 0c 0 000 0 0. 0...oI 011 0JN 0 r- r- -. 0cI 00 0.4 0 " NNN C S S N CYINSC4 04 NS C4 - M 0-4"ə L- a WjIn .. (D(0(0 CC4 >.N XN ( -000000 0 -N 1 100 -4N4 lUli < tg N -4C

A sensitive and specific method for measurement of multiple retinoids in human serum with UHPLC-MS/MS

PubMed Central

Arnold, Samuel L. M.; Amory, John K.; Walsh, Thomas J.; Isoherranen, Nina

2012-01-01

Retinol (vitamin A) circulates at 1–4 μM concentration and is easily measured in serum. However, retinol is biologically inactive. Its metabolite, retinoic acid (RA), is believed to be responsible for biological effects of vitamin A, and hence the measurement of retinol concentrations is of limited value. A UHPLC-MS/MS method using isotope-labeled internal standards was developed and validated for quantitative analysis of endogenous RA isomers and metabolites. The method was used to measure retinoids in serum samples from 20 healthy men. In the fed state, the measured concentrations were 3.1 ± 0.2 nM for atRA, 0.1 ± 0.02 nM for 9-cisRA, 5.3 ± 1.3 nM for 13-cisRA, 0.4 ± 0.4 nM for 9,13-dicisRA, and 17.2 ± 6.8 nM for 4oxo-13-cisRA. The concentrations of the retinoids were not significantly different when measured after an overnight fast (3.0 ± 0.1 nM for atRA, 0.09 ± 0.01nM for 9-cisRA, 3.9 ± 0.2 nM for 13-cisRA, 0.3 ± 0.1 nM for 9,13-dicisRA, and 11.9 ± 1.6 nM for 4oxo-13-cisRA). 11-cisRA and 4OH-RA were not detected in human serum. The high sensitivity of the MS/MS method combined with the UHPLC separation power allowed detection of endogenous 9-cisRA and 4oxo-atRA for the first time in human serum. PMID:22192917

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, FY 88. Part 6. (Data-Easton Machine Corporation)

DTIC Science & Technology

1988-01-01

City, State, and ZIP Code) 7b. ADDRESS (City, State, and ZIP Code) Arlington, VA 22202-4302 8a. NAME OF FUNDING/SPONSORING 8b. OFFICE SYMBOL 9 ...to u 0 300- I cInr 1- IL71 O0 0 1= I v V- EU 10001- I 0 M fa V CE0 1 CI o 100 3(- 9 -4 3-. 3t-4 -4 CA4 4 -4 W-4 - .. 4’.-I-4 00.f.4 4-I 0-I I...I 00003’ 44-.4.44 r4 r0) 1- 00 U44a ( 9 WLAC’) o .,’r-r-- r-3=-.-r 00 r- i-. I’- 1-’o- 411Wa0(1 I M ( t1nC n S 0M U n . (n(C’In (1n n ( 0nL C) 0 M1 M

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, Fiscal Year 1987. Part 9. Hawthorne Srvc. & Medical U SC-Input Output Technology.

DTIC Science & Technology

1987-01-01

0 0 m 0 V7 a Mo00tI 04 aF 04 0 U..04 0 0 4 0004 000 0004 00v4l A a 1 o < 1 - 08- 0 m 4N00ŕ-1.- 0 0o1-) 000-) CN 00- co D W -co 00- W- ca 0 0 4 004...a 00 0 ’nw 000 gr Go00 C- 4)NN 01?--(- ... J 40 CAD 00 00- -40-00 0 000 3 4 ’- m- -A4 (D a- E ’ w- Cl m- 0 0 M4 0-l (14 af ((0-C’N 0A (4 V) 0 0 0)0...4, -4-4 lin n in -4 (00(4 I -- 10-4( IC) Mum0 1 r a I0 > 0 0. ) 0 1C 04 ’ -4 = tC z -4 4 ( )- 4. J I M 04 N af .- C.-4- C14 If,4 cl UI 0, C r

Engine Bird Ingestion Experience of the Boeing 747 Aircraft - Expanded Data Base (October 1986 - September 1989).

DTIC Science & Technology

1992-07-01

AMENAS, ALGERIA N FGN 408 0 420 0 506 0 1334 0 IBA IBADAN, NIGERIA N FGN 1382 0 706 0 484 0 2572 0 1BZ IBIZA, SPAIN N FGN 124 1 220 0 294 1 638 2 ICT ...BRAZIL S FGN 978 0 1646 0 4088 0 671M 0 MDE MEDELLIN , COLOMBIA N FGN 312 0 312 0 314 0 938 0 M0I MAKURDI, NIGERIA N FGN 730 0 695 0 375 0 1800 0 MDK

All Prime Contract Awards by State or Country, Place, and Contractor. Part 13 (Allendale, New Jersey -Otero, New Mexico)

DTIC Science & Technology

1990-01-01

N R CA (A CAl (no L4 0 Ij)4Q # j)C U n<U U uM0 ii C-4 ɘ :: 0. H00 .- -Wt .- -()0 M L 1 L -0 nI n L 4( I M 1((0 11 44 4 44 4 44 4 4 z4 4 0) ISO ...0 > ə IMN C13 0t Z 0 044>>~ 0000c 1,41 1IM" Ŗ 1- ) I-- I-- I.- I- U4 Io 14- (I), isL)0z 00 I- ISO ION It -~W ) f z i IION N/ 0A 0 1. 2 0 on 01-- w 0...ZI o M cv ISO . CL ’) C) cn0 000 2>C) 1 0 0 -6 co C1 mI ii 2 W- 0) 0 1-4 0 0404 0 O DU)C> (c In < wi coC’ II La.) Z"I 00 I-I > w o .Joo40 C) loo oo w>0C

All Prime Contract Awards by State or Country, Place, and Contractor, FY 84. Part 10 (Alliance, North Carolina - Woodburn, Oregon).

DTIC Science & Technology

1984-01-01

Highway, Suite 120 4 Arlington, VA 22202-4302 8a. NAME OF FUNDING iSPONSORING TBb. OFFICE SYMBOL 9 . PROCUREMENT INSTRUMENT IDENTIFICATION NUMBER...CODES 18. SUBJECT TERMS (Continue on if necessary and identity by biock number) FIELD GROUP SUB-GROUP - --- D T 1Q C% 9 ABSTRACT (Continue on reverse it...ZNNCYNNNNNNNNNcl C ci Y YNNNNNNNCY 9 ~- Z N N~ m zN C3 0). N (N NY N N NN N \\ NN N N NN N N N Nm C* . D 0 0 0 0 0 0) (D( ~0 0 CD0LL0 0 0 Q0 00 00 00 0 M W UOoO 0

[Study of the supra-glottic pressure during partial constriction of the vocal tract].

PubMed

Suares, M; Cayrayre, F; Ouaknine, M; de la Brèteque, B Amy; Giovanni, A

2004-01-01

Phonation in a small plastic tube 22 cm length and 5 mms diameter (basic exercise of the method of Dr Amy de la Brèteque), is current practice in vocal rehabilitation in France. This work aims to show the effects of this method on the glottic vibration. The hypothesis was that at the time of phonation in the tube with a strong flow as recommended in the method, the vocal cords vibrate without contact. This limits the mechanical trauma at this level. We have analyzed the sound production in a tube in 11 trained and not trained subjects. We simultaneously collected the intra-oral air pressure and the vocal signal which was subjected to a spectral analysis. Spectral analysis confirmed that the signal was produced correctly i.e. with a strong flow and without interruption of the sound less rich in harmonics. We interpreted these results in the light of our preceding works on the glottic vibration and we show that this vocal production was of the sinusoidal type; this implies the absence of physical contact between the vocal cords, which validates our hypothesis. Further works are necessary to better understand the physical relations between the supra-glottic aerodynamic phenomena and the vibratory functioning of the vocal cords and also to analyze the therapeutic potential ofthe method within speech therapy rehabilitation.

Ap4A and ADP-beta-S binding to P2 purinoceptors present on rat brain synaptic terminals.

PubMed Central

Pintor, J.; Díaz-Rey, M. A.; Miras-Portugal, M. T.

1993-01-01

1. Diadenosine tetraphosphate (Ap4A) a dinucleotide stored and released from rat brain synaptic terminals presents two types of affinity binding sites in synaptosomes. When [3H]-Ap4A was used for binding studies a Kd value of 0.10 +/- 0.014 nM and a Bmax value of 16.6 +/- 1.2 fmol mg-1 protein were obtained for the high affinity binding site from the Scatchard analysis. The second binding site, obtained by displacement studies, showed a Ki value of 0.57 +/- 0.09 microM. 2. Displacement of [3H]-Ap4A by non-labelled Ap4A and P2-purinoceptor ligands showed a displacement order of Ap4A > adenosine 5'-O-(2-thiodiphosphate) (ADP-beta-S) > 5'-adenylyl-imidodiphosphate (AMP-PNP) > alpha,beta-methylene adenosine 5'-triphosphate (alpha,beta-MeATP) in both sites revealed by the Ki values of 0.017 nM, 0.030 nM, 0.058 nM and 0.147 nM respectively for the high affinity binding site and values of 0.57 microM, 0.87 microM, 2.20 microM and 4.28 microM respectively for the second binding site. 3. Studies of the P2-purinoceptors present in synaptosomes were also performed with [35S]-ADP-beta-S. This radioligand showed two binding sites the first with Kd and Bmax values of 0.11 +/- 0.022 nM and 3.9 +/- 2.1 fmol mg-1 of protein respectively for the high affinity binding site obtained from the Scatchard plot. The second binding site showed a Ki of 0.018 +/- 0.0035 microM obtained from displacement curves. 4. Competition studies with diadenosine polyphosphates of [35S]-ADP-beta-S binding showed a displacement order of Ap4A > Ap5A > Ap6A in the high affinity binding site and Ki values of 0.023 nM, 0.081 nM and 5.72 nM respectively.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:8485620

Department of Defense Manpower Requirements Report for FY 1992

DTIC Science & Technology

1991-02-01

primary readi- ness inhibitor . To address this problem, the ARNG is involved in an effort to improve MOSQ through command emphasis and increased...D r-Oec o4- No NI aO OO Nln c CNI O ON0 m 0 cs00 ONCC% 00 0 0ON00000 -4 C (D n O LnO’ n 0% N 4 01 0 0 0 000 N% CYI0N a -T0 0%i l 0m40 0 1 C14 0 14 0

Using King Vision video laryngoscope with a channeled blade prolongs time for tracheal intubation in different training levels, compared to non-channeled blade.

PubMed

Kriege, Marc; Alflen, Christian; Noppens, Ruediger R

2017-01-01

It is generally accepted that using a video laryngoscope is associated with an improved visualization of the glottis. However, correctly placing the endotracheal tube might be challenging. Channeled video laryngoscopic blades have an endotracheal tube already pre-loaded, allowing to advance the tube once the glottis is visualized. We hypothesized that use of a channel blade with pre-loaded endotracheal tube results in a faster intubation, compared to a curved Macintosh blade video laryngoscope. After ethical approval and informed consent, patients were randomized to receive endotracheal Intubation with either the King Vision® video laryngoscope with curved blade (control) or channeled blade (channeled). Success rate, evaluation of the glottis view (percentage of glottic opening (POGO), Cormack&Lehane (C&L)) and intubating time were evaluated. Over a two-month period, a total of 46 patients (control n = 23; channeled n = 23) were examined. The first attempt success rates were comparable between groups (control 100% (23/23) vs. channeled 96% (22/23); p = 0.31). Overall intubation time was significantly shorter with control (median 40 sec; IQR [24-58]), compared to channeled (59 sec [40-74]; p = 0.03). There were no differences in glottis visualization between groups. Compared with the King Vision channeled blade, time for tracheal intubation was shorter with the control group using a non-channeled blade. First attempt success and visualization of the glottis were comparable. These data do not support the hypothesis that a channeled blade is superior to a curved video laryngoscopic blade without tube guidance. ClinicalTrials.gov NCT02344030.

Final Tactical Decision Aid (FTDA) for Infrared (8-12 Micrometers) Systems - Manual Version. Appendix B. Insolation and Sky Radiation Tables,

DTIC Science & Technology

1982-09-15

for use in determining solar irradiance as a function of terrain elevation is also presented. Errors in computed sea level values of sky radiation as a...Renobserved if the Ground Were at Sea Level .. ..................... 365 5. Sky Radiation (W SK).. .. ....... ....... ....... 366 SKYY and Dewpoint SKY...WS -M 00 OiLn 00 00 00 .0 .. q . m1’ C14 IN’ .- *- * .0 *0 *0 0 .0 0 Y -’ CD N inC 0 M W N L- 04c 1- Wq an’ U) 14 N- 00 00 Mcq N N r- (’IC’I) (’ - M -0

Dynamic Particle Weight Remapping in Hybrid PIC Hall-effect Thruster Simulation

DTIC Science & Technology

2015-05-01

e+ l 9 Numb e t· D e nsity (M ean # / rn3 ) Contr o l 1 -0 2.0 l.O Axial Position, (ern) o. o I 00.0 ZOO . 0 300.0 -400.0 Compuatio n a l...ean # / m 9 ) 3. e+ l9 Dynatnic 1.0 2 .0 l.O Axial Position. (ern) 0. 0 I 00.0 ZOO . 0 300.0 -400.0 C o mputatio n a l Particles (M e a n

Ultraviolet Lasing Transitions in Diatomic Molecules

DTIC Science & Technology

1980-01-01

N N CU co Nm N U) 0 𔃺 0 v4 40 0 M.- 4) LA 𔃺 N , Oh W N OhN 0 N ’ ) ’ (4 LA 0n Oh N 0 U) N \\0 Lm 𔃺 N \\0 P % r- r- C4 m 4 -4 -4 q 0 0 -4...calculations indicate 0 20 U,ot 10 2 p I I p0 Fig. ll. TIME (10 ඉ) Pi Ola aba for N , C-8 Mba. at 33"I A. ezefed in sir a 14 roT pmwie by (a) Modd BD0 mi (b...state is now commonly called the B state by experimentalists. Simple considerations suggest that both this

Geographic List of Prime Contract Awards. Oct 1992-Sep 1993. FY 1993. (Aiea, Hawaii-Wichita, Kansas). Part 5

DTIC Science & Technology

1994-03-01

Z . = ac ac acca H I0o00) , aZ ZZ ZZ Z 2Z ZZ ZZ 2c z z Z a2 ca ci c2 c2 cz 2 r ; H 1 00 0 M U * M 00 M -N tVCOO0 n (D -4 C) r. NNYInCV) .- N -(..-4 0...Ifa1 0.-i K( N (0 (0 I L 0 to 0 (0 K U. I (0wzl0 K 0.-4 0.4.4.-qV4 0 .4 4 OMMMMMMMMMCf(fffff Off CV) - V4 ffm ff) 0 (yf) v E0-Z -4N3ýf(O% NNCYM*VW

A molecular beam photoionization mass spectrometric study of Cr(CO){sub 6}, Mo(CO){sub 6}, and W(CO){sub 6}

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Y.; Liao, C.; Ng, C.Y.

1997-09-01

The photoionization efficiency (PIE) spectra for M(CO){sub n}{sup +} (n=0{endash}6) from M(CO){sub 6}, M=Cr, Mo, and W, have been measured in the photon energy range of 650{endash}1600 {Angstrom}. Based on the ionization energies for M(CO){sub 6} and appearance energies (AEs) for M(CO){sub n}{sup +} (n=0{endash}5) determined here, we have obtained estimates for the sequential bond dissociation energies (D{sub 0}) for CO{endash}M(CO){sub n{minus}1}{sup +} (n=1{endash}6). The comparison between the D{sub 0} values for the Cr(CO){sub 6}{sup +} system obtained here and in the recent collisional induced dissociation and theoretical studies suggests that D{sub 0} values for CO{endash}M(CO){sub n{minus}1}{sup +} (n=3{endash}6) basedmore » on this PIE experiment are reliable. The PIE results reveal the general trend for individual D{sub 0} values that D{sub 0}[CO{endash}Cr(CO){sub n{minus}1}{sup +}]{lt}D{sub 0}[CO{endash}Mo(CO){sub n{minus}1}{sup +}]{lt}D{sub 0}[CO{endash}W(CO){sub n{minus}1}{sup +}] (n=3{endash}6). The comparison of the first D{sub 0} values for M(CO){sub 6}{sup +} obtained here and those for M(CO){sub 6} reported previously provides strong support for the theoretical analysis that the importance of relativistic effects, which give rise to more efficient M to CO {pi}-back-donation in M(CO){sub 6}, is in the order W(CO){sub 6}{gt}Mo(CO){sub 6}{gt}Cr(CO){sub 6}. {copyright} {ital 1997 American Institute of Physics.}« less

All Prime Contract Awards by State or Country, Place, and Contractor, FY 88. Part 14. (Aberdeen, North Carolina-Zanesville, Ohio)

DTIC Science & Technology

1988-01-01

a) > fr wUO wua w U.1 W 0 w 0C(00O-4 C 0 a. W(1 La- 0--cl - (n U, -.1 i.* .- " I,.1- wI- 44 Z(0(01- C(0.-4 l(0 w0 1-0 co 0Nz W 00 W(1-lZ Cr-Z um1 00...l N N l N 1 N N-4.-4 ’-4-4.-IN -4 1 00r- I Nl NI N1 N" -4-4 C1 "NNNli- I01( Q L I 1 -4 -4 - 4 -4 fr -- CNNN U) 100’V I I1Q000 I N N1 -4 -4 N4 N 04NN...4 .- 4 . 4 4- I 00(0 I C~ -r- I- r 0-r-r.r- fr - l P- Qr- r- or- ar- >J- >j- >,t- r- r- r- . DO(0 o ’n I4400000 40000000 1000 440 m0 m 0 mU0

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 5. (Comtech Microwave Corp.-DOB Corporation)

DTIC Science & Technology

1989-01-01

8217)N1-orn-4 04-4.-4 on 0 (D c’)N"U) N CV3 If1. I moo0 If 0o c) 4N ( 4 -4 .4 -40 -4Nci-4 -414) 003a4a1 moo If Nn -4 >3 100 Coc 1’) -4,1 a01)0 t mo 4 0)N...Col01ə ’ IfN 1.- 0 r,0 a - 0 1" 0 4 0NC14 M M 40000o r-NjN I,_-4 " 411.I’ 14 iI 400fto 1 0 140 10 4000 10000 ol 100 1 t I-N a 401<-4 110) (0 00 00 10...1-1-1-1-1-1-1- . 1- j-1-1-1 - . . -j -. 0 )JJ . J. 1 . . . . j . met M)-4 44 000 a 0 0 0 0 0 0 0 0 00 0 0 0 0 0 0 0 0 C.4 If ( 44< 100 00 00 -j4 of

[Not Available].

PubMed

Villa-González, Emilio; Rodríguez-López, Carlos; Barranco-Ruiz, Yaira; Cabezas-Arévalo, Luis Fabián; Chillón, Palma

2016-06-30

Objetivo: analizar la concordancia de dos métodos de medición (Google MapsTM vs. Sistema de Información Geográfica) para la determinación de la distancia desde el domicilio familiar hasta el colegio.Métodos: un total de 542 escolares de entre 8-11 años de edad (media = 9,36 ± 0,6) del sur de España participaron en el estudio, facilitando la dirección de su domicilio familiar. La distancia desde el domicilio familiar al colegio se calculó mediante la utilización de dos programas diferentes:Google MapsTM y Sistema de Información Geográfica (GIS) en ruta y en línea recta. La asociación entre ambos métodos fue analizada utilizando la correlación de Spearman y el grado de acuerdo a través del coeficiente de correlación intraclase (ICC), así como el método Bland Altman.Resultados: la correlación entre ambos métodos de medición propuestos fue muy significativa (r = 0,966, p < 0,001; r = 0,984, p < 0,001; y r = 0,954, p < 0,001, respectivamente), y la concordancia fue excelente (ICC = 0,96, p < 0,001; ICC = 0,92, p < 0,001; ICC = 0,97, p < 0,001).Conclusiones: los métodos de medición estudiados podrían ser utilizados en función de las necesidades de la investigación, al presentar ambos una alta concordancia. Sin embargo, se recomienda la utilización del Sistema de Información Geográfica en ruta si se cuenta con medios yfinanciación, por tratarse de un método constatado en fiabilidad y validez.

AFOSR Technical Report Summaries, October - December 1989

DTIC Science & Technology

1989-12-01

0 .0- 1. . - 0. tun a> %.U I L A~ La~ IL’ Ui +IC-~ ~ ~ - 3, - 1C6 .-0t " L VO 00C V .~~@ c 1nV) 13- S0-’ N E-L 15 - In1 In M- V *.inUZ EL- I- m45 v L...3 -0 0Z 0>.CJ - j Li 0 L O.V C) 0 a 1 0/ .Ou. <- C U L- L 0 r- X A L 0 PIx -- 0 n> 0 La -- . < D- 0 zAW m z u 0 . E U Ul I- a . u0-. Im U 1-W0L N U r

Official Guard and Reserve Manpower Strengths and Statistics: Third Quarter Fiscal Year 1990

DTIC Science & Technology

1990-06-01

0 .t C n ’ab N K K x Ko K- ccmP K K, K, qo o mc rK x K K oo Tc njMI *IKn K KTgk AK ~ ~ ~ ~ ~ ~ ~ ~ A Ki 0 0 I .a C O C P nP 0 0 0 . 0 K I . . 0 4m...0 ft0..sott 40. In 181, L St.1 0o - cc I I~ I I 40St a, aNN ro 00.r-10 040 cmmu 0a, K " mI o Go mI-r I KO 4 .0 .44 .21) r- .400 418 Go1 pqI’S ID n...wK* cc-cK% i nh, " nr 4. .40 Na StI - in0 m 4 1.4so a1Mt T Sa Ko Km N P NS t KwS a3> w3 >0o 0 0 0 Im1 0. 1142 00. pi10. %Dm NIGo00NOK6hi 0 *N1 0.~r

Dollar Summary of Prime Contract Awards over $25,000 by Contractor, State or Country, and Place. Part 1 (102 Construction Inc, Oklahoma City, Oklahoma -- Bay Cities Refuse Co, Sunnyvale AFS, California), FY1991

DTIC Science & Technology

1991-01-01

L I-m 0d 0 td 4 10.1-4 4L o ) 0-40 # 2 I XI i( iC c u :W ( W .1 1- Ie ix W0- cc -4- (00 0 0-0 CO I E 00N0 00((0 UU) 0 0 0 3 00 o *zz a txa...43 td 00 0N -4 t - ) CZ IS WI - IL < (M I. 1.- (0 (0 z -- 0 0N f 1 Ii Iu -4 --4z L 0 I CI D- = 0- x I- c ow ( I- I I e 0 I.I. w 0 1Q4 0 0- I0.- C )C...LU 05 01t- 0 00 -4-4 o~c cc I- I c P:M 0 4e 1 C1 cl-4 -4 44 N I c 00 td E(0 c0 10 00 w 4 4- N N < 4-0 -4-4 - 0 c I 44 - 9 -I M IA- I 00 E >I (,C. 14

Calibration in dogs of a subcutaneous miniaturized glucose sensor using a glucose meter for blood glucose determination.

PubMed

Poitout, V; Moatti-Sirat, D; Reach, G

1992-01-01

The feasibility of calibrating a glucose sensor by using a wearable glucose meter for blood glucose determination and moderate variations of blood glucose concentration was assessed. Six miniaturized glucose sensors were implanted in the subcutaneous tissue of conscious dogs, and the parameters used for the in vivo calibration of the sensor (sensitivity coefficient and extrapolated current in the absence of glucose) were determined from values of blood glucose and sensor response obtained during glucose infusion. (1) Venous plasma glucose level and venous total blood glucose level were measured simultaneously on the same sample, using a Beckman analyser and a Glucometer II, respectively. The regression between plasma glucose (x) and whole blood glucose (y) was y = 1.12x-0.08 mM (n = 114 values, r = 0.96, p = 0.0001). The error grid analysis indicated that the use of a Glucometer II for blood glucose determination was appropriate in dogs. (2) The in vivo sensitivity coefficients were 0.57 +/- 0.11 nA mM-1 when determined from plasma glucose, and 0.51 +/- 0.07 nA mM-1 when determined from whole blood glucose (t = 1.53, p = 0.18, n.s.). The background currents were 0.88 +/- 0.57 nA when determined from plasma glucose, and 0.63 +/- 0.77 nA when determined from whole blood glucose (t = 0.82, p = 0.45, n.s.). (3) The regression equation of the estimation of the subcutaneous glucose level obtained from the two methods was y = 1.04x + 0.56 mM (n = 171 values, r = 0.98, p = 0.0001).(ABSTRACT TRUNCATED AT 250 WORDS)

The Army Study Program.

DTIC Science & Technology

1983-05-31

a- - - - - m .aKU i~ n I n i n K K iK G. (J- zow w w w m m cc co n CD a) w u u w w w v IA a :aP aj I 4p . V 4 p IV V A 4 4 v I . V a t1 1 4 acca n...xi W Uc -K. U4 0-0)0- 0- 4 -01 4 02 - n U ) U x14 4, 04:1)6 hi u 0) ki V3 1 z- P7 a. ** hi * U,0 .04 K hi 0 Z) hiJ 0. U W 9 4 W 0. U a Cc z A. 4A 0

Dollar Summary of Federal Supply Classification and Service Category by Company. Section 1: Supplies and Equipment. Fiscal Year 1993. (6105 Motors, Electrical, Able Inc. - 9999 Miscellaneous, Zulu Pacific Air Service). Part 2

DTIC Science & Technology

1994-03-01

W) CV) Ln C4 ý qr v 0 V m tD Ln mw qw co en CY) m Pý- CD CA CL 0 E x 0 ui 0 (D tO lD r,. rý. ej 0 Cn 0 Cj CY) (D (n Go L) W L) 0 LO CY) (Y) Cl rý m w...C " L~ 0 - -L C. L. L. s- ol U=~ M0C0 o.-0eý= G CO C- Co*-I’U rC ’U td 06 0 060 0 m 0 f’>-𔃾J (n 4- (d )O00 ŕ 0 4- ed - 4- 1’-O 0 0 0 - 05 4dS- 4...Mcc CL L) 41 CL 0 cc U) = cn u 0 c 4n td (D (n u u z w go to 0 LID = a. - I u L) U - < 0 w (D CL 0 w cn u I-- u 0 ww < I-- z 1-- 0 (n cy 4 = (D Cn L

All Prime Contract Awards by State or Country, Place, and Contractor. Part 17 (Abbeville S. Carolina-Eldorado Texas)

DTIC Science & Technology

1990-01-01

zi-Zx a IN -4-4 1. *4-4-4-4 P~. NINI r- r- 4 0) -4 I- 11 ~w0.fp- a C 0 0 40 40000 0 000000 0 0 0 ON ofWI-4 II Z 2z Z 222 z zzzlcz2 z z z 0 .4- N 2...ISN < INN NN ɜ in 0C14 :: 0 ɜ 0 M NJ 4 N N 4I N I L0-4 C .) C , C ..0 0 0000 C0 000000 0 0 0 I U N- l ) N N NPJN N N N 44 8 0-4C40 P4 NN rN 04~0 88M c ...88, &N 0-4Ci C4 0N 00 04 0000 0 000 0 04 0 .0N C S 8 88 C Ŕ,8 4 (74 C4 0000N 4N 0000004" C44 If U C.N) N 0N J N N N N u8 8044 8 2 --- > --- >>> 𔃾

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 20 (Tru & Associates Inc-VTM Group Joint Venture)

DTIC Science & Technology

1990-01-01

000w0c0000000w ( 0 6 S Coco to t to 00000 c, -0000.00.J 04 NN - N000NNCJ 04 000000000 00000 WW U SY NN N N N 4 4 C91000 000000cl.0 40 050 00 0 a0 0 0C 4 O...If106000 N4 06 -a M.’ 4 400 cl NV Mqt CI1- 0t SY MI-I.-IF- Sn-4 "- N W 0I N 000S4o-I CAN 10 000 0oCo 600 3Ni In6 < O OM UUUUm COOw 11 .1 NS 064C U-a...00a1.6 r-2 = Nabe O U0 I 4NC U I 1C)050.410󈧒 Wq(0 I w to0 I C’) ow 0 1 -I I 0 I0 0U I 0 4N U~Nocc0001-004n0Nl-INO -4 M(Y) 0D0 G 01- r-_-1 -40 M01

The Joint US/UK 1990 Epoch world Magnetic Model

DTIC Science & Technology

1991-10-01

N cE’ "- 4 94 0 -a N fP 9u 1 I. - 4 4I opN uI uI - - - - - - -- - 9 IrI 06 ~. -A 9u. f3 0. v’ u4 -3 .0- 4 CC 00 ’C. -u -29 G- 01 W’ 10’ WCC...RE/R AR=AOR**2 C C BR=0O. BT=0O. BP=0O. BPP =O. C DO 70 N=1,MAXORD AR=AR*AOR DO 60 M=0O,N C COMPUTE UNNORMALIZED, ASSOCIATED LEGENDRE POLYNOMIALS AND...N- 1) ELSEI PP(N)=CT*PP(N I )-K(N,M)*PP(N-.2) END IF PARP=AR*PP(N) BPP = BPP +FM(M)*TEMP2*PARP ENDIF C CI 60 CONTINUE 70 CONTINUE CI C IF (ST .EQ. 0.0

An Interactive Computer Program for the Preliminary Design and Analysis of Marine Reduction Gears.

DTIC Science & Technology

1982-03-01

4 E-4 c 043 04 4 E- PQ = 24 0 0 E- m 2054 4a =44 Env)2 d0 a b43 09 0 4 I6.4 44 = w. 0k2. . U)3c m 00 I= =C * 4 0 . O)U ad i 0 0~P In3 U= 4 40:M = 4 m...pa *Q4 2 c4~ .~ co N ra a9.* o H 00a = = :b4 H~ H U (3 C) U- of *4= t. E- H)40 UUO *n04 043 q N. W E-4 E-4 1.4-0 31 H 000 oi-4. H4 - M0 2I 2 04 E- HU...aO o %-c ’. %D in0 o f 3W -+V E4pa a noM pa pa pCa 0 pa H14 . pa H 1.4 pa ~00 MtH x 4 -4 U 4E4E4 0 E-4 H E ~ CaM N4 -40 0 UE- E.UE- u 0 c E4 0 9 E-4

The antagonistic effect of neostigmine on rocuronium-, clindamycin-, or both-induced neuromuscular blocking in the rat phrenic nerve-hemidiaphragm

PubMed Central

Kim, Seung Soo; Chung, Chan Jong; Lee, Seung-Cheol

2011-01-01

Background Neostigmine augments clindamycin-induced neuromuscular block and antagonizes rocuronium-induced neuromuscular block; however, it remains unclear whether neostigmine enhances the neuromuscular blocking (NMB) that is caused by combinations of rocuronium and clindamycin. The intent of this study was to determine whether neostigmine potentiates the muscle relaxation that is induced by combinations of rocuronium and clindamycin and to estimate whether both clindamycin and rocuronium have synergistic actions on NMB. Methods Forty-one left phrenic nerve-hemidiaphragms (from male Sprague-Dawley rats, 150-250 g) were mounted in Krebs solution. Three consecutive single twitches (ST, 0.1 Hz) and one tetanic tension (50 Hz for 1.9 s) were obtained for each increase in concentration of rocuronium or clindamycin. The concentrations of rocuronium were cumulatively increased until an 80% to 90% reduction in ST was attained in the Krebs solutions pre-treated with 0 (n = 5), 0.1 (n = 1), 0.25 (n = 1), 0.5 (n = 4), or 1.0 (n = 1) mM clindamycin or with 0 (n = 4), 0.1 (n = 1), 0.5 (n = 5), 1.0 (n = 5), or 2.0 (n = 4) mM clindamycin in combination with 250 nM neostigmine, and so were the concentrations of clindamycin in the Krebs solutions pre-treated with 0 (n = 6) or 250 nM (n = 6) neostigmine. Results Clindamycin increased the potency of rocuronium for ST and tetanic fade, irrespective of the presence of neostigmine. Neostigmine shifted the concentration-response curve of rocuronium to the right in the presence or absence of clindamycin. The interaction between rocuronium and clindamycin was synergistic when clindamycin concentrations were in excess of 0.5 mM, irrespective of the presence of neostigmine. Conclusions Neostigmine may partially antagonize the neuromuscular block that is induced by a combination of clindamycin and rocuronium. Clinicians are advised to be aware that clindamycin synergistically increases the degree of rocuronium-induced neuromuscular block, even when neostigmine is present. PMID:22110886

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 6. (Dobbins Lou, Inc.-Fahey Machinery Co., Inc.)

DTIC Science & Technology

1989-01-01

0 (-4N4- H0 -.4C.) -. 4 a) () -40) -4 0 ) w 0N %- M C(00) z to IG0 -Iff1 ._40 N I 0 -4 4 5 0 ) L0)) 0 .-. 01-4~ . 0 .4NCJ0) 1-1-4 -4-4 0 )’ ao I -4N... 0 -4 00 0 -n O Olo(c x( c -d0 41r- -C4 N00 to II0 0 - I N N C1,1 0 r -4 -4 r-U 1 0 ... .J0)00N MLI-I0-41 1 00 o0 30- 30 30)mv0v-, 0 a o 5 Qo oN 0114/81 M...100000000000 4I <_1B4.4 110 0D 0n 0n 0 0 00 ofl W I Owl>u if ON 0C Or0N ON" 0 -I

Recommendations for neoadjuvant pathologic staging (ypTNM) of cancer of the esophagus and esophagogastric junction for the 8th edition AJCC/UICC staging manuals.

PubMed

Rice, Thomas W; Ishwaran, Hemant; Kelsen, David P; Hofstetter, Wayne L; Apperson-Hansen, Carolyn; Blackstone, Eugene H

2016-11-01

We report analytic and consensus processes that produced recommendations for neoadjuvant pathologic stage groups (ypTNM) of esophageal and esophagogastric junction cancer for the AJCC/UICC cancer staging manuals, 8th edition. The Worldwide Esophageal Cancer Collaboration provided data for 22,654 patients with epithelial esophageal cancers; 7,773 had pathologic assessment after neoadjuvant therapy. Risk-adjusted survival for each patient was developed. Random forest analysis identified data-driven neoadjuvant pathologic stage groups wherein survival decreased monotonically with increasing group, was distinctive between groups, and homogeneous within groups. An additional analysis produced data-driven anatomic neoadjuvant pathologic stage groups based only on ypT, ypN, and ypM categories. The AJCC Upper GI Task Force, by smoothing, simplifying, expanding, and assessing clinical applicability, produced consensus neoadjuvant pathologic stage groups. Grade and location were much less discriminating for stage grouping ypTNM than pTNM. Data-driven stage grouping without grade and location produced nearly identical groups for squamous cell carcinoma and adenocarcinoma. However, ypTNM groups and their associated survival differed from pTNM. The need for consensus process was minimal. The consensus groups, identical for both cell types were as follows: ypStage I comprised ypT0-2N0M0; ypStage II ypT3N0M0; ypStage IIIA ypT0-2N1M0; ypStage IIIB ypT3N1M0, ypT0-3N2, and ypT4aN0M0; ypStage IVA ypT4aN1-2, ypT4bN0-2, and ypTanyN3M0; and ypStage IVB ypTanyNanyM1. Absence of equivalent pathologic (pTNM) categories for the peculiar neoadjuvant pathologic categories ypTisN0-3M0 and ypT0N0-3M0, dissimilar stage group compositions, and markedly different early- and intermediate-stage survival necessitated a unified, unique set of stage grouping for patients of either cell type who receive neoadjuvant therapy. © 2016 International Society for Diseases of the Esophagus.

Evaluation of the Vesicating Properties of Neutralized Chemical Agent Identification Set (CAIS) Components

DTIC Science & Technology

1997-06-01

W a% n% e’w-4T .0 3 C/2 W4 rýr- C~eJCN mCN Cým 0 Cn 14.4 000 0 en mnen~’ m - 00 a E- 000 0 0000 000 0 0a0 U 00 0 0 00 000 W a a000 00 C. wUn - 0 m( 0 4...3-; __- N__ I _ __ _ S~ it, CI a___QI S__ teD I Q__-___,________ v-i All measurernents in =fl~himeters R = E~rytherna * N/A =Not appUcaS[.e B = Edema

Geographic List of Prime Contract Awards. Oct 91 - Sep 92. FY92. (Germany - Classified Location Foreign)

DTIC Science & Technology

1993-01-01

n C . 0 4 - ’ ’ U-- 5 U U U0 U U U 0 0 0 0 0)00 0 S.W E 0 M m 01 &- cC-4 aC ad a 0C 4 4 4 (A-0 40 0 E - 0 CL 0 o 0 c - V L0 Z r o 0e V! . - & 4 4 ,1 4...00 Q0 M000000420000 .1 U w 4 000-s 4 11 4N <Cio N < 5 \\jOCOa-1 -1-4i(71N " ൒O 4C’ 4(1.1 4000000000><><>C>c M4 100-4 4f 0))) 0) 0) ) 0) 0) O () ()0...no04w is of 1 004w I LL) to 14L 001*0 4’ <<Cc� 44 4 0040)4 <<<Cc44444 44 4 44 o0- " 5 :: J-- -.J - JJJJ-j-J -J.J--Ii- . ft U-4 M 0 :: XXZX of 0

2012 ESTCP Live Site Demonstrations Massachusetts Military Reservation Camp Edwards, MA. ESTCP MR-1165 Demonstration Data Report Central Impact Area TEMTADS MP 2x2 Cart Survey

DTIC Science & Technology

2013-01-31

372,250.272 4,618,632.972 0.30 Horizontal Across Track T-004 Blank 372,252.872 4,618,629.872 N/A N/A N/A T-005 Medium ISO 372,255.575 4,618,626.492...4.46 4.89 4.668 0.12 1.33 1.40 1.36 0.03 1.24 1.30 1.27 0.02 Med. ISO 1.69 1.77 1.73 0.031 0.94 1.01 0.98 0.02 0.92 0.96 0.94 0.01 Figure 5-9...1.00 0.5 155mmP -2.70 -0.90 -1.80 0.5 81mmM -3.50 -2.00 -3.00 0.4 Med. ISO 0.80 2.10 1.50 0.4 S ho tp ut 15 5m m P 81 m m M M ed . I S O M ag ne

The Outcome of ATC Message Complexity on Pilot Readback Performance

DTIC Science & Technology

2006-11-01

3 6% 00 6. 36 % O m is si on o f n um be r e le m en t(s ) n = 1 78 0. 28 % 3 . 60 % 0. 14 % 0. 55...um be r e le m en t(s ) n = 1 28 0. 14 % 1. 80 % 1. 38 % 05 .8 1% 04 .4 3 % 1. 24 % 02 .9 0% 01 7. 70 % Su bs tit ut io n of o ne... en t n = 7 23 0. 41 % 5. 53 %

Prime Contractors with Awards Over $25,000 by Name, Location, and Contract Number. Part 6. (Kenett Corporation-Mid South Dredging, Inc.)

DTIC Science & Technology

1989-01-01

o 04 - a. 4CJC zAw IL I 0.H 8 :3~~ z I0 0.DC 49 .I QE C-) w z zn 04. .. .4.4.4 . 44 ~ t .00.0c. -3 cc) C> t10 N r- OD C,-4 IZD CD - 0n 00 040 -O...U 4-4 4- - tun OD 0 m4 00 C)I C0 0 OD N0 -4t ) DO U) 4 (Ii tc CtD( -C -4 OD -DC tNkn ( IQr-O N0 c. ( z oe) 6 -r- 0) -Cjj < 0 4 4 m4 -4t 0 O m- t4 (n...r0 N n 00 L)) 0 00 0) 0 0 0 C6EuI C 40 . tun a, U - UrC 400 0% 41 4.- v1 0 )Z( 1 ,, Cli (no 0 4i W0 L- 3U 4 0 0I 0 I a. am u. U 0 0- H-I -CrU t wC0. UZ

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 2. (American Nucleonics Corp.-Beachler Mark Associates)

DTIC Science & Technology

1989-01-01

Inn In -4 MOI -e4.~~3fm >U 6-z a ~ Wz ;w<<* -4.c 00)00 P.U~ 11.0U 22 02A4UZ z222 >Z 2222 02 * 00 U 0.-411)M)00 P. 0) U)n In C0U)M)004 0o RtO P 0)1a L o...z2 22222222zzz B 40 I W) 11 222 2 222 Z 222zz Z zzzzz2ZZZZ 11 1 Com 00n00 IV0) rto 04 l (0-4q O0 ()N04 0 ) I 0(0-4in0)-0000 B- >I woo B 11400) Rt...400o cc00. C X a vs I M-4 N X LU 4 0ULI L.. I.L. g,-4N-41U’I 4 N x 0U 5 cc N .40-4 N 2NGO(0 U-4 <-4 0)4 k ~N00004 (1 X wo Cci *00 IT4000 If .0 I 0-4

Three whole-wood isotopic reference materials, USGS54, USGS55, and USGS56, for δ2H, δ13C, δ15N, and δ18O measurements

USGS Publications Warehouse

Qi, Haiping; Coplen, Tyler B.; Jordan, James A.

2016-01-01

Comparative measurements of stable hydrogen and oxygen isotopes in wood are hampered by the lack of proper reference materials (RMs). The U.S. Geological Survey (USGS) has prepared three powdered, whole-wood RMs, USGS54 (Pinus contorta, Canadian lodgepole pine), USGS55 (Cordia cf. dodecandra, Mexican ziricote), and USGS56 (Berchemia cf. zeyheri, South African red ivorywood). The stable isotopes of hydrogen, oxygen, carbon, and nitrogen in these RMs span ranges as δ2HVSMOW from –150.4 to –28.2 mUr or ‰, as δ18OVSMOW from + 17.79 to + 27.23 mUr, as δ13CVPDB from –27.13 to –24.34 mUr, and as δ15N AIR-N2 from –2.42 to + 1.8 mUr. These RMs will enable users to normalize measurements of wood samples to isotope–delta scales, and they are intended primarily for the normalization of δ2H and δ18O measurements of unknown wood samples. However, they also are suitable for normalization of stable isotope measurements of carbon and nitrogen in wood samples. In addition, these RMs are suitable for inter-laboratory calibration for the dual-water suilibration procedure for the measurements of δ2HVSMOW values of non-exchangeable hydrogen. The isotopic compositions with 1-σ uncertainties, mass fractions of each element, and fractions of exchangeable hydrogen of these materials are:USGS54 (Pinus contorta, Canadian Lodgepole pine)δ2HVSMOW = –150.4 ± 1.1 mUr (n = 29), hydrogen mass fraction = 6.00 ± 0.04 % (n = 10)Fraction of exchangeable hydrogen = 5.4 ± 0.6 % (n = 29)δ18OVSMOW = + 17.79 ± 0.15 mUr (n = 18), oxygen mass fraction = 40.4 ± 0.2 % (n = 6)δ13CVPDB = –24.43 ± 0.02 mUr (n = 18), carbon mass fraction = 48.3 ± 0.4 % (n = 12)δ15NAIR-N2 = –2.42 ± 0.32 mUr (n = 17), nitrogen mass fraction = 0.05 % (n = 4)USGS55 (Cordia cf. dodecandra, Mexican ziricote)δ2HVSMOW = –28.2 ± 1.7 mUr (n = 30), hydrogen mass fraction = 5.65 ± 0.06 % (n = 10)Fraction of exchangeable hydrogen = 4.1 ± 0.5 % (n = 30)δ18OVSMOW = + 19.12 ± 0.07 mUr (n = 18), oxygen mass fraction = 35.3 ± 0.2 % (n = 6)δ13CVPDB = –27.13 ± 0.02 mUr (n = 18), carbon mass fraction = 53.3 ± 0.6 % (n = 12)δ15NAIR-N2 = –0.3 ± 0.4 mUr (n = 16), nitrogen mass fraction = 0.25 % (n = 4)USGS56 (Berchemia cf. zeyheri, South African red ivorywood)δ2HVSMOW = –44.0 ± 1.8 mUr (n = 30), hydrogen mass fraction = 5.65 ± 0.05 % (n = 10)Fraction of exchangeable hydrogen = 6.6 ± 0.3 % (n = 30)δ18OVSMOW = + 27.23 ± 0.03 mUr (n = 12), oxygen mass fraction = 41.1 ± 0.2 % (n = 6)δ13CVPDB = –24.34 ± 0.01 mUr (n = 12), carbon mass fraction = 47.3 ± 0.2 % (n = 12)δ15NAIR-N2 = + 1.8 ± 0.4 mUr (n = 15), nitrogen mass fraction = 0.27 % (n = 4)

Development of a Computer Model for Scattering of Electromagnetic Waves by a Turbulent Wake

DTIC Science & Technology

1976-10-01

01. W WO V m PiM NNN 0 0P o NI’ggo*.Ne~~~ 40 .INWN 4 I-.oAg , i- £ oc..eec a, *e ggg0eg.c e C30c O Ooa. Coo e r.g..00000mo.. k w 30 N on. N M...0 y 6 . N -.1, -0𔃺 64 6404 i 09000 aI ~III IL. W I 4 0 0, 1W0 I 0~ I 4 S- qw~ ____________’ .9 us, 4K C*I: 4W 0 fo # l C w 6 0o m. Ott ilfl,,0 0

Thyroid hormone deiodinases D1, D2, and D3 are expressed in human endothelial dermal microvascular line: effects of thyroid hormones.

PubMed

Sabatino, Laura; Lubrano, Valter; Balzan, Silvana; Kusmic, Claudia; Del Turco, Serena; Iervasi, Giorgio

2015-01-01

Endothelial system acts as a large endocrine organ in the human body; however, little is still known about the regulative role of THs on endothelial cells. Aim of the present study was to investigate the expression of the TH deiodinases (D1, D2, and D3) and TH receptors (TRα1, TRα2, and TRβ1) in an endothelial microvascular cultured cell model (HMEC-1), after stimulation with triiodothyronine (T3, 10-100 nM), thyroxine (T4, 10-100 nM), and reverse T3 (rT3, 1-10 nM). DIO1 was significantly inhibited by T4 at 10 and 100 nM (p < 0.001). rT3 significantly inhibited DIO1 at 1 nM concentration (p < 0.01) and stimulated DIO1 at 10 nM dosage (p < 0.001). T4 and rT3 significantly inhibited DIO2 at all concentrations. DIO3 was induced at 100 nM T3 (p < 0.05) and 100 nM rT3 (p < 0.01), and TRα1 and TRα2 mRNAs were significantly increased after 100 nM T3 treatment (p < 0.05) and decreased after 1 and 10 nM rT3 (p < 0.05). TRβ1 was significantly increased by all THs at different concentrations: 10 nM T3 and 100 nM T3 (p < 0.05), 1 nM rT3 (p < 0.001), and 100 nM T4 (p < 0.01). D1 and D2 protein levels were evaluated, but no significant difference was observed for any hormonal treatment. For the first time, we found that the TH deiodinases and receptors are expressed in endothelial HMEC-1 cells. These findings might be of significant clinical relevance, given the important regulatory role of the endothelium as first barrier to the bloodstream.

Socioeconomic Incentives for Migration from Mexico to the United States: Magnitude, Recent Changes, and Policy Implications.

DTIC Science & Technology

1980-07-01

research assistants in the gathering of masses of raw census data and data from the- Sistema Geo-municipal which provided more than one-half of the total...services. 43 The indicators were gathered for all the Mexican regions from the Sistema Geo-Municipal, a computerized government information bank in...N toC ) 0 - O~0 C N ( 0 4J C𔃺 (4 in C’) 0. V4 T-4 0 0- vi iN m- t 0 Crt- s-C (N (N (N (N (N (N (N; (N (4 (N (4 (N (4 C4) M’) Cr) 0 . -0 .0 CA - 04As

Demand Forecasting and Revenue Requirements, with Implications for Consideration in British Columbia,

DTIC Science & Technology

1983-05-01

future financing obligations will be 782 largely determined by the conditions of the financial 783 markets , the amount of construction activity that is...L 4 w- MM t 14 * 0 00 M00 0 0 0nU M4 C? 0C 4 4 ’C) * 0 3 0 0N% AI 0 % M 41 C 0 MNl -4 N4 -4-4 0 6. n ad 4 LI L 1 4p % N 61-4 I 01 -54- t: 1% r.a -4 "E...34Residential Demand for Electricity," Quarterly Review of Economics and Business , Vol. 11, Spring 1971, pp. 7-22. Yang, Yung Y., "Temporal Stability

Measuring tissue back-pressure--in vivo injection forces during subcutaneous injection.

PubMed

Allmendinger, Andrea; Mueller, Robert; Schwarb, Edward; Chipperfield, Mark; Huwyler, Joerg; Mahler, Hanns-Christian; Fischer, Stefan

2015-07-01

Limited information is available on injection forces of parenterals representing the in vivo situation. Scope of the present study was to investigate the contribution of the subcutaneous (sc) tissue layer to injection forces during in vivo injection. Göttingen minipigs received injections of isotonic dextran solutions (1-100 mPas) into the plica inguinalis using different injection rates and volumes (0.025-0.2 mL/s and 2.5 vs. 4.5 mL). The contribution of the sc back-pressure to injection forces was found to increase linearly with viscosity and injection rate ranging from 0.6 ± 0.5 N to 1.0 ± 0.4 N (1 mPas), 0.7 ± 0.2 N to 2.4 ± 1.9 N (10 mPas), and 1.8 ± 0.6 N to 4.7 ± 3.3 N (20 mPas) for injection rates of 0.025 to 0.2 mL/s, respectively. Variability increased with viscosity and injection rate. Values are average values from 10 randomized injections. A maximum of 12.9 N was reached for 20 mPas at 0.2 mL/s; 6.9 ± 0.3 N was determined for 100 mPas at 0.025 mL/s. No difference was found between injection volumes of 2.5 and 4.5 mL. The contribution of the tissue was differentiated from the contribution of the injection device and a local temperature effect. This effect was leading to warming of the (equilibrated) sample in the needle, therefore smaller injection forces than expected compensating tissue resistance to some parts. When estimating injection forces representative for the in vivo situation, the contribution of the tissue has to be considered as well as local warming of the sample in the needle during injection.

Geographic List of Prime Contract Awards. Oct 1992-Sep 1993. FY 1993. (Barrington, Isld-Williamson, Texas). Part 11

DTIC Science & Technology

1994-03-01

CyC)444 11_ n (0m m m ~ V c0 ( 40 00-4.- 4 -0 -4 -42 z O CAO1000Z de ON I~si CON1 02 0000000000 00 >-0000000000000 Cl!0 X0000 C toON Iiz Cci OOOOOOO 0...C0OV N 4 v de . d 00-49I 0~Ia I r*U- 4 4444 4 4 00ON 0 0 cThII1 600000 N 0004 ULg4 4(< . Co :: en UU4 4 P44 4r,0CUU0 0 0 0 If 1 U 4cqu 0 NIUJ-MG00 0 0 0...m CO) 0 Cq ’D rý 100111OLn mo If I Ca 0 Go 11 om 000 00 . 0 V 0-4 0Ln(DN - 0 M 0040 - 0 m 0OV(D - 0 (D if I cacao 11 z It Z Ln Z Ln-i C r4% z to

Thermophysical Properties of Matter - The TPRC Data Series. Volume 1. Thermal Conductivity - Metallic Elements and Alloys

DTIC Science & Technology

1970-01-01

370 .n, . ... .. ...................... . 1295 371 n’. . . ...... . .. . . . . ....................... 129 372 ASt...C-CZN ~ ~ C 0~~ C-7 -C~ -CD - all I II I I 1, 1,1 1 , I 02 Aw ~9D ... I00 -0C CO ~ CC 0!ClCC~ CJC ~CC0C 0 N ~C~a-.~C~.tz ~ ~ 3’CCC- ’I~ 0C1 N , - 7s...o) ) 0. o Q a)o Q-IQ 0 v4) V .N.M04 5 e CC cnn 0 W . -4 m 0 -. ~ ~ l v) M0N~2 0)040 CjC -llLf )IVA%3)a ant- -’GN 3lY IJ 2.30II I -7 1 , I! I I- _I .< i

Clinical outcomes of patients with hypothyroidism undergoing percutaneous coronary intervention

PubMed Central

Zhang, Ming; Sara, Jaskanwal D.S.; Matsuzawa, Yasushi; Gharib, Hossein; Bell, Malcolm R.; Gulati, Rajiv; Lerman, Lilach O.

2016-01-01

Abstract Aims The aim of this study was to investigate the association between hypothyroidism and major adverse cardiovascular and cerebral events (MACCE) in patients undergoing percutaneous coronary intervention (PCI). Methods and results Two thousand four hundred and thirty patients who underwent PCI were included. Subjects were divided into two groups: hypothyroidism ( n = 686) defined either as a history of hypothyroidism or thyroid-stimulating hormone (TSH) ≥5.0 mU/mL, and euthyroidism ( n = 1744) defined as no history of hypothyroidism and/or 0.3 mU/mL ≤ TSH < 5.0 mU/mL. Patients with hypothyroidism were further categorized as untreated ( n = 193), or those taking thyroid replacement therapy (TRT) with adequate replacement (0.3 mU/mL ≤ TSH < 5.0 mU/mL, n = 175) or inadequate replacement (TSH ≥ 5.0 mU/mL, n = 318). Adjusted hazard ratios (HRs) were calculated using Cox proportional hazards models. Median follow-up was 3.0 years (interquartile range, 0.5–7.0). After adjustment for covariates, the risk of MACCE and its constituent parts was higher in patients with hypothyroidism compared with those with euthyroidism (MACCE: HR: 1.28, P = 0.0001; myocardial infarction (MI): HR: 1.25, P = 0.037; heart failure: HR: 1.46, P = 0.004; revascularization: HR: 1.26, P = 0.0008; stroke: HR: 1.62, P = 0.04). Compared with untreated patients or those with inadequate replacement, adequately treated hypothyroid patients had a lower risk of MACCE (HR: 0.69, P = 0.005; HR: 0.78, P = 0.045), cardiac death (HR: 0.43, P = 0.008), MI (HR: 0.50, P = 0.0004; HR: 0.60, P = 0.02), and heart failure (HR: 0.50, P = 0.02; HR: 0.52, P = 0.017). Conclusion Hypothyroidism is associated with a higher incidence of MACCE compared with euthyroidism in patients undergoing PCI. Maintaining adequate control on TRT is beneficial in preventing MACCE. PMID:26757789

Fatigue Stressors in Simulated Long-Duration Flight. Effects on Performance, Information Processing, Subjective Fatigue, and Physiological Cost

DTIC Science & Technology

1980-12-01

transferase or monoamine oxidase. These enzymes are similar to cholinesterase which destroys acetycholine, the agent secreted by the para- sympathetic nervous...the adrenergic neurons. Levels of norepinephrine are controlled in part by the intraneural metabolic activity of the enzyme monoamine oxidase. Chronic...GJ 4’ to Lu~ (n N. 0 N CIO.I V) m~ -4 4 V) -4 -- 4 ot o0m - N 0 LOlCD W m%0 w M %* " m m m v m v " -4 -4- inC-4J-4 - Coq 00.~. 0 a)) a. CD-v U X X x L

Project Ranking 2

DTIC Science & Technology

1986-05-01

CCI) Wq.4)O ’)0)𔃾 COND -) ( CXPWqWVD- - w 0 -M m (0 M -T ID’ig -- >0 fCV-- W IDO-C)O)C� ,,.III-I~n -- v Mori vDI 0) O)wcl-W..,ID f- to WIM4) (3O...en 0- 0000 - I-U .0J0LLAI * XU~L. - .3*fe*2-4)m Z -umeo-Z-a-In2 - ~ u w-m-391 42- 2048 % %’~4-0 --- l.0 nw w- 11 2~4..Z-4 n- -a0f~0* . am 0- X0 -U-K .4I

Estimating USAF Aircraft Recoverable Spares Investment.

DTIC Science & Technology

1980-08-01

ITEMS Multiple Regression Equation RCCAVI - 178.44118(AC)’ 39843(AVFAC) ൰ 62 2 e 27003 (IB ) + 2.4257(1R e 1.0 9 99 (IF/A) + 1.1 8 11 (1C) + 1.100...79- I M In *~Nt M h IOOO N1 0 , C 0 0 30~ It- N t- INN0010 - t 10 N M mt00 01 0,󈧈 01c 0 0 0000’ ast-00 10%I I t~-.. ~ ISO ~ tO It- . lO tfls4 I1 MD...0K 0 4 #40 D Jr *0 2z < I 0 -I - . - - I 0 I IN , 0 H0 PA C, :,C n BCY -4 0 -a C I z nL Z4 w11 00 WI Z4 4 ) L. zWI W -98- w Iq IN N05 IsO I 5I 00 0 1

Prime Contract Awards by State or Country, Place and Contractor. Part 10 (Royal Oak, Michigan - Garwood, New Jersey), FY1991

DTIC Science & Technology

1991-01-01

C M M M M M m -0 a Iiia 0-40 e f3 00) a 2S 4ca * 0 co~ : i ag ~ :0 0 U qt 0 W U c EWI 044 U * U* * O M-4c𔃺 -0 us I LJ.E)(U 0 8N 00 U 0 U -4" U0)o -4...4444~~- CY4 -404 -4-I *-40 MfI0-4"< I CC0 .d(f =:I- NNi =(n =~OOOOOOOOOf .(Al =N =CU) m ag iIn0-40 II 4.z uz uz2zz u2 uzzzzzzzzzzzz uz uZ Qz uZr H I02...0000 11 02-4NOHm 0000000 000 0 0) 0) 00 00000J a u< I IW-4CN02H 00 0 00 -W - -- 4-1 1--- fIT M4 10002W )0 1aJ4 I’ I0-40IM 440244 44 -( Ag -< -4< -00

Novel 99mTc(III)-azide complexes [99mTc(N3)(CDO)(CDOH)2B-R] (CDOH2=cyclohexanedione dioxime) as potential radiotracers for heart imaging.

PubMed

Liu, Min; Zheng, Yumin; Avcibasi, Ugur; Liu, Shuang

2016-11-01

In this study, novel 99m Tc(III)-azide complexes [ 99m Tc(N 3 )(CDO)(CDOH) 2 B-R] ( 99m Tc-ISboroxime-N 3 : R=IS; 99m Tc-MPboroxime-N 3 : R=MP; 99m Tc-PAboroxime-N 3 : R=PA; 99m Tc-PYboroxime-N 3 : R=PY; and 99m Tc-Uboroxime-N 3 : R=5U) were evaluated as heart imaging agents. Complexes [ 99m Tc(N 3 )(CDO)(CDOH) 2 B-R] (R=IS, MP, PA, PY and 5U) were prepared by ligand exchange between NaN 3 and [ 99m TcCl(CDO)(CDOH) 2 B-R]. Biodistribution and imaging studies were carried out in Sprague-Dawley rats. Image quantification was performed to compare their initial heart uptake and myocardial retention. 99m Tc-ISboroxime-N 3 , 99m Tc-PYboroxime-N 3 and 99m Tc-Uboroxime-N 3 were prepared with high RCP (93-98%) while the RCP of 99m Tc-MPboroxime-N 3 and 99m Tc-PAboroxime-N 3 was 80-85%. The myocardial retention curves of 99m Tc-ISboroxime-N 3 , 99m Tc-PYboroxime-N 3 and 99m Tc-Uboroxime-N 3 were best fitted to the bi-exponential decay function. The half-time of the fast component was 1.6±0.4min for 99m Tc-ISboroxime-N 3 , 0.7±0.1min for 99m Tc-PYboroxime-N 3 and 0.9±0.4min for 99m Tc-Uboroxime-N 3 . The 2-min heart uptake from biodistribution studies followed the ranking order of 99m Tc-ISboroxime-N 3 (3.60±0.68%ID/g)> 99m Tc-PYboroxime-N 3 (2.35±0.37%ID/g)≫ 99m Tc-Uboroxime-N 3 (1.29±0.06%ID/g). 99m Tc-ISboroxime-N 3 had the highest 2-min heart uptake among 99m Tc radiotracers revaluated in SD rats. High quality SPECT images were obtained with the right and left ventricular walls being clearly delineated. The best image acquisition window was 0-5min for 99m Tc-ISboroxime-N 3 . Both azide coligand and boronate caps had significant impact on the heart uptake and myocardial retention of complexes [ 99m Tc(N 3 )(CDO)(CDOH) 2 B-R]. Among the radiotracers evaluated in SD rats, 99m Tc-ISboroxime-N 3 has the highest initial heart uptake with the heart retention comparable to that of 99m Tc-Teboroxime. 99m Tc-ISboroxime-N 3 is a promising alternative to 99m Tc-Teboroxime for SPECT MPI. Copyright © 2016 Elsevier Inc. All rights reserved.

Innovator. A Financial Expert System

DTIC Science & Technology

1990-01-01

M )M 3lz 4 Ot.-l di- : C 4) -n M Vi’~ M d)Vi - 3 c 0 Z"nc - 10. Z CO. Of(L C 0. cxCL4 - (1 a~. 4- C a ra. C at 0. ff Cr. COx4L z -> n" C C L 0 E L o Lm...C -x/UI L %. . Ix/U a. 4- w 0 1 . %- U L . 4 - a . 4 x- w a. . % x- u a0 D 0.~x w a2 C - . n C- a. (L 0 CXCL4 - C L C 0 I Q. M . %-CMI L4 C.- O

Influence of the vocal cord mobility in salvage surgery after radiotherapy for early-stage squamous cell carcinoma of the glottic larynx.

PubMed

Gorphe, Philippe; Blanchard, Pierre; Temam, Stephane; Janot, François

2015-10-01

Disease relapses occur in up to 40% of cases after radiotherapy (RT) for early-stage glottic laryngeal neoplasms, and the foremost remaining treatment option is salvage total laryngectomy (STL). Our objectives were to review the outcomes of patients treated with salvage surgery after RT for early-stage carcinoma of the glottic larynx and to assess prognostic factors. We retrospectively analyzed 43 patients who underwent surgery. Overall and disease-free survival rates among subgroups were calculated and compared, stratified by preoperative stage, vocal cord mobility and postoperative histopathologic data. Recurrences occurred 22.7 months after the end of RT. Surgery was STL in 33 cases (76.8%). The main prognostic factors associated with survival rates were initial vocal cord mobility, vocal cord mobility at the diagnosis of recurrence, and changes in mobility. Vocal cord mobility is an important clinical criterion in treatment decision making for early-stage glottis carcinoma and remains important during follow-up.

Transoral Laser Microsurgery in Early Glottic Lesions.

PubMed

Sjögren, E V

2017-01-01

To give an overview of the evolvement of transoral laser microsurgery (TLM) in the treatment of early glottic carcinoma and highlight the contribution of recent literature. The indications and limits of TLM have been well specified. Effects on swallowing have been well documented. Introduction of narrow-band imaging (NBI) and diffusion-weighted magnetic resonance has been shown of additional value for outcome. The first reports on transoral robotic surgery show that it may be of added value in the future. TLM for early glottic carcinoma (Tis-T2) has very good oncological outcomes with indications of higher larynx preservation in TLM than that in radiotherapy. The anterior commissure is a risk factor if involved in the cranio-caudal plane, and reduced vocal fold mobility is a risk factor when this is due to arytenoid involvement. The best voice results are achieved when the anterior commissure can be left intact along with part of the vocal fold muscle although even in larger resections, patient self-reported voice handicap is still limited.

Y-Circulator with Dielectric Filler

DTIC Science & Technology

1981-12-10

Y , y LU UL iLU V Shch, shch SK K, k ’b 7p•• S. WA L,b/ V Y , y M m M, m bb b b H H H N N , n 33 a 9 E, e 0 o 0 0 O, o m 00 m Yu, yu n n 17 m...ii ’I ! DOC 1275 PAGE 1 Y -CIRCULATOR WITH DIELECTRIC FILLER A. K. Stolyarov, I. P. Tyukov, V. N . Shakhgedanov, A. A. Shilova. The known Y -circulators...FTD-ID( RS)T-1275-81 FOREIGN TECHNOLOGY DIVISION 0, Y -CIRCULATOR WIrH DIELECTRIC FILLER by A.K. Stolyarov, I.P. Tyukov, et

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 15 (Mountain States Caulking Inc-Pangborn Corp)

DTIC Science & Technology

1990-01-01

I 4 i (0> 0) (0 ?-- CoN 4C.A<>(0 0 9 3 020 i3f 04--4---0 -4 aNN C 0 VO N4 04000C0 33 3020 goN)L0(?-C 0 Of Co 0 ~ )0) 0)0) --- 03(3 C7(0 0)4 I3 3 02...M I -IO1 1 4NnInC0a laII0.I :Tl otIc 00o4-4 LIOr CO > -- 4-4 0-0-4 N m1 it-11m il C)I- o 00) 111 t 11 L- -4 0004 f Oi0 C ~ I -444- CON I NT N CL L...7) 0) I () 00 J! 0) 0)J 0. ) 0) 0) 0) .1  402 C 40 0 H 0 F- 0 0 H 344 if 2 I11-4" -I 0 a- 1- 1 0 0 444I CON 11I <- H < 044 : n 44 41 4cc 04E𔃺in

Department of the Air Force Supporting Data for Fiscal Year 1986 Budget Estimates Submitted to Congress February 1985, Descriptive Summaries, Research, Development, Test and Evaluation

DTIC Science & Technology

1985-02-01

Wk B«U Oil &b 0 i »>BCbBB«00 fa s 0 0 0 0 * « •HR« i s fa •r* •T< 0 x:^>u0«to«-<-> -a fa to (J k kTJ<ri r...4J y <M •H JS o o U B 0 y 0 4J a w «M u b >n y b 0 1 0 « i o 0 •n o rH O y •P4 <M TJ 0 0 • a«M oil b •n TJ o B o 0 r^ o 4J 4-> 0 0 o 0 0...Ifc, «j 3 bXIBOn 0COU9 03 0 I . n O. O X Oil ) iHSUfO JJ 3 JJ ftJO B 0O0 9 0TJLiX0»~iU0

A Unified Approach to UXO Discrimination Using the Method of Auxiliary Sources

DTIC Science & Technology

2006-10-12

0 and is sin(mφ) for p = 1, bpmn the spheroidal expansion coefficients. Eq. (2.1) is a decomposition of a primary magnetic potential into a number of...spheroidal expansion coefficients bpmn can be derived as bpmn = − 2n+ 1 γπH0dP ′mn (ξ0) (n−m)! (n+m)! ∫ 1 −1 Pmn (η)hξ ∫ 2π 0 Hprξ (η, ξ0, φ)Tpm(φ)dφdη...the object’s response for each pmn excitation mode (Chen et al., 2004; Sun et al., 2005), i.e., Hsc(r) = M ∑ m=0 N ∑ n=m 1 ∑ p=0 bpmn Nq ∑ i=1 qpmni G

Alpha List of Prime Contract Awards. Oct 92-Sep 93. FY93. (U. S. Refuse Services Inc. - Vystar Group Inc.). Part 19

DTIC Science & Technology

1994-03-01

u IU U) ’ 4U I U 0 U4 00. 09 0 -a0 W) o Gao W)o G0 00) 00 Wan ON NC’ NO I o If (Ŗ r . oc o oc 4 a’P0 0 C ) -’*G0COGOD le40 .. r. 0 00 0 P-P P-V (O...In It 0 1 O cc Cmm0oi L)LnL L n 0 inI O n nIn 0N in rn jIni nvi)v)wi n n n In in Ln (0((0(n0u) o00 art v0N(m0mvi m u i n iv2Om NL 11 4- 1ov WO a i

Analysis of p21-Activated Kinase Function in Neurofibromatosis Type 2

DTIC Science & Technology

2010-01-01

6,6′-dithiobis) for 10 min, before stimulation with 10% FCS (PAA, Pasching, Austria), 0.5 μM forskolin (Sigma-Aldrich, St. Louis, USA), 10 nM β1...0.5 μM forskolin (Sigma-Aldrich), 10 nM β1- heregulin144–244 (Genentech), 0.5 mM 3-isobutyl-1-methylxanthin (IBMX, Sigma-Aldrich) and 2.5 μg/ml...0.5 μM forskolin (Sigma-Aldrich), 10 nM β1-heregulin144–244 (Genentech), 0.5 mM 3-isobutyl-1-methylxanthin and 2.5 μg/ml insulin (both from Sigma

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 17. (Singer Company, The-Syscon Corporation)

DTIC Science & Technology

1989-01-01

00 0) if Im to, HZ -4 fr 0 00 00 Iin0(-0) C>0 D0 0 - -4 1 1- I ea( 0C0 tint’f-00C> 10 0 Lr 0.) a. 00 on : I enc - It OO O N - N ( N N ~ 0 4 4 - N N - 0...C< ml I1 (-1C( c iI 1 -4 -4- - - eNC LN ( INS I .N N . 1,N jXN~N L-.-4 .- 1N C -. of 0-4Nɘ � ( L’O -00 t CO m 0 O 00 000 m4 COO 0( if IM C...00 c 0> 0a 0I 0 C>0 0 GOq’ it en-4N( -4 o o o- o0 oa W-a oo o oo 0 4)Q C IMP e-4i ca I- L N cl NNNN1 "N LC’ N OXeJ C1, ENc , N cN 16- L- ) to Of Im en-4

Prime Contractors with Awards over $25,000 by Name, Location, and Contract Number. Part 6 (RGI Inc, San Diego, California -- Technology Specialist Inc, Arlington, Virginia), FY1991

DTIC Science & Technology

1991-01-01

L) W z WU- L) .4 WCl)L3( 0 WWW < WW W 0i z m I 0 I= 4 C4cc( IU3 U 4n z L) Uz C) 4 Z UZ u -) Utz 0 U 0 0 I -C U 4 U; I4 Cl aW L, L) W9 nE 0- 0 U3W...0 0 I ~ 1j ~ 0> ix ( 0m.- LI)1. (n 0. Z3 Li -C En LI :1 I’" T, CL, 4H H L) Www I L r u - 0- 0 . 0. 8 . > 0 0:000: 104. 10 N0 ) 0 LI L C.4 I L 0 1.. H...m M 0c A 04 4 .4 042 . CC u U) 0 439 4 a.Z-M a 0 C z 4 www 0O > 0~ L) oH 0 g 2 > cn L) 0 44 0 0 Su~A 08 U3H 0 . Z w.~4. CO~ W ’OCCOO) f OC)OC ix0< HI

A new series of oxycarbonate superconductors (Cu(0.5)C(0.5))(m)Ba(m+1)Ca(n-1)Cu(n)O2(m+n)+1

NASA Technical Reports Server (NTRS)

Takayama-Muromachi, E.; Kawashima, T.; Matsui, Y.

1995-01-01

We found a new series of oxycarbonate superconductors in the Ba-CaCu-C-O system under high pressure of 5 GPa. Their ideal formula is (Cu(0.5)C(0.5)(m)Ba(m+1)Ca(n-1)Cu(n)O2)((m+n)+1) ((Cu,C)-m(m+1)(n-1)n). Thus far, n = 3, 4 members of the m = 1 series, (Cu,C)-1223 and (Cu,C)-1234, have been prepared in bulk while n = 4, 5 members, (Cu,C)-2334 and (Cu,C)-2345, have been prepared for the m = 2 series. (Cu,C)-1223 shows superconductivity below 67 K while T(sub c)'s of other compounds are above 110 K. In particular, (Cu,C)-1234 has the highest T(sub c) of 117 K.

Geographic List of Prime Contract Awards. Oct 91 - Sep 92. FY92. (Barrington Rhode Isld - Ft Bliss Texas)

DTIC Science & Technology

1993-01-01

0) 0) 40 0 -4 (1(1m(1l N 00 -44--N 444(0 1 40 -4 oo<a000-4 0aQ 0-0 00Co -4 -40 00 o 0 0 200Cp-4 N/ Ii 4 al it0( ’A.N N N-4J1’(JN’ J- -4INA NONiN N...a 1 (004t H 4R M’ viN " la1-4 ino NNN 1(4 U1- 1C)CIMC’) 9590 #A-4 twoC𔃻 9110ý -4 1 coo (0 4 ) 0) Q)-4 (1)o IVn l ON0(000 00 411- 0COOP- 01-4 4)(0 0

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 3. (Beachy Lumber Co.-Campanova, Richard MD)

DTIC Science & Technology

1989-01-01

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In-situ Measured Carbon and Nitrogen Uptake Rates of Melt Pond Algae in the Western Arctic Ocean, 2014

NASA Astrophysics Data System (ADS)

Song, Ho Jung; Kim, Kwanwoo; Lee, Jae Hyung; Ahn, So Hyun; Joo, Houng-Min; Jeong, Jin Young; Yang, Eun Jin; Kang, Sung-Ho; Yun, Mi Sun; Lee, Sang Heon

2018-03-01

Although the areal coverage of melt pond in the Arctic Ocean has recently increased, very few biological researches have been conducted. The objectives in this study were to ascertain the uptake rates of carbon and nitrogen in various melt ponds and to understand the major controlling factors for the rates. We obtained 22 melt pond samples at ice camp 1 (146.17°W, 77.38°N) and 11 melt pond samples at ice camp 2 (169.79°W, 76.52°N). The major nutrient concentrations varied largely among melt ponds at the ice camps 1 and 2. The chl-a concentrations averaged from the melt ponds at camps 1 and 2 were 0.02-0.56 mg chl-a m-3 (0.12 ± 0.12 mg chl-a m-3) and 0.08-0.30 mg chl-a m-3 (0.16 ± 0.08 mg chl-a m-3), respectively. The hourly carbon uptake rates at camps 1 and 2 were 0.001-0.080 mg C m-3 h-1 (0.025 ± 0.024 mg C m-3 h-1) and 0.022-0.210 mg C m-3 h-1 (0.077 ± 0.006 mg C m-3 h-1), respectively. In comparison, the nitrogen uptake rates at camps 1 and 2 were 0.001-0.030 mg N m-3 h-1 (0.011 ± 0.010 mg N m-3 h-1) and 0.002-0.022 mg N m-3 h-1 (0.010 ± 0.006 mg N m-3 h-1), respectively. The values obtained in this study are significantly lower than those reported previously. A large portion of algal biomass trapped in the new forming surface ice in melt ponds appears to be one of the main potential reasons for the lower chl-a concentration and subsequently lower carbon and nitrogen uptake rates revealed in this study. A long-term monitoring program on melt ponds is needed to understand the response of the Arctic marine ecosystem to ongoing environmental changes.

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, Fiscal Year 1987. Part 13. Modular Engineering-Okinawa GM Corporation.

DTIC Science & Technology

1987-01-01

44 44 0 ( 4 0 I 14 4 n bJ4 11) - 0 0 0 0 4𔃾 o c40N C,) a ima) -t.4 n c00000.co 03- 4 4 )- 0 00 C(,I0)0 0) r c)00 W0 0 enC Go6 ,r 00 c 0 w P00(IW0...cI enC en (0) m) r-- 0 00G L 0 enO -’ M0 U-100 U 00 L) 0( m 1 0 0 -40 0 00 0C - 0-4 00 0 00 0 *44( C II M 4-- I-. (D04- r- P4r- r., (D r- to r-- - r- r...q 14 Z LJOOO LaDO W-7𔃺)hI0~ 0.OXX OOON-400000 0( 00 0. LAO LOCDM𔃺 -󈧄 XLALA)Oao L)0~ o mO U00 ~ 0 ": 0 0 V-40 ’-’CC10 M ICC 0000D04

Prime Contract Awards Over $25,000 by Major System, Contractor and State Part 2 (AVG NAVY-SMR NAVY)

DTIC Science & Technology

1990-01-01

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Alpha List of Prime Contract Awards. Oct 1991 - Sep 1992. FY 1992. (North Bay Landscaping - Peterson Machine Products Corp)

DTIC Science & Technology

1993-01-01

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Microwave Acoustics Handbook. Volume 4. Bulk Wave Velocities-Numerical Data.

DTIC Science & Technology

1980-06-01

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Technical Papers Presented at the Defense Nuclear Agency Global Effects Review - 7-9 April 1987. Volume 1

DTIC Science & Technology

1987-04-30

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Alpha List of Prime Contract Awards. Oct 91 - Sep 92. FY 92. (Reichlmeter - Season All Industries Inc)

DTIC Science & Technology

1993-01-01

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Community Noise Exposure Resulting from Aircraft Operations. Volume 5. Acoustic Data on Air Force Propeller Aircraft

DTIC Science & Technology

1978-02-01

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Durable and Rechargeable Antimicrobial Textiles

DTIC Science & Technology

2013-12-01

N -halamine Precursor Concentration (%) G ra ft in g Y ie ld ( % ) 0 100 200 300 400 500 600 700 800 900 1000 1100 1200...1300 C h lo rin e c o n te n t (p p m ) 80 90 100 110 120 0.0 0.2 0.4 0.6 0.8 1.0 Wet Pickup (%) G ra ft in g Y ie ld ( % ) C h lo rin e c o n te n ...temperature ( o C) C h lo rin e c o n te n t (p p m )

Assessing the neurotoxic effects of palytoxin and ouabain, both Na⁺/K⁺-ATPase inhibitors, on the myelinated sciatic nerve fibres of the mouse: an ex vivo electrophysiological study.

PubMed

Kagiava, Alexia; Aligizaki, Katerina; Katikou, Panagiota; Nikolaidis, Georgios; Theophilidis, George

2012-03-01

Palytoxin (PlTX) is a marine toxin originally isolated from the zoantharians of the genus Palythoa. It is considered to be one of the most lethal marine toxins that block the Na⁺/K⁺-ATPase. This study was designed to investigate the acute effects of PlTX and ouabain, also an Na⁺/K⁺-ATPase blocker, on the mammalian peripheral nervous system using an ex vivo electrophysiological preparation: the isolated mouse sciatic nerve. Amplitude of the evoked nerve compound action potential (nCAP) was used to measure the proper functioning of the sciatic nerve fibres. The half-vitality time of the nerve fibres (the time required to inhibit the nCAP to 50% of its initial value: IT₅₀) incubated in normal saline was 24.5 ± 0.40 h (n = 5). Nerves incubated continuously in 50.0, 10.0, 1.0, 0.5, 0.250 and 0.125 nM of PlTX had an IT₅₀ of 0.06 ± 0.00, 0.51 ± 0.00, 2.1 ± 0.10, 8.9 ± 0.30, 15.1 ± 0.30 h, and 19.5 ± 0.20 h, respectively (n = 5, 3, 4, 4, 10). PlTX was extremely toxic to the sciatic nerve fibres, with a minimum effective concentration (mEC) of 0.125 nM (n = 5) and inhibitory concentration to 50% (IC₅₀) of 0.32 ± 0.08 nM (incubation time 24 h). Ouabain was far less toxic, with a mEC of 250.0 μM (n = 5) and IC₅₀ of 370.0 ± 18.00 μM (incubation 24.5 h). Finally, when the two compounds were combined--e.g. pre-incubation of the nerve fibre in 250.0 μM ouabain for 1 h and then exposure to 1.0 nM PlTX--ouabain offered minor a neuroprotection of 9.1-17.6% against PlTX-induced neurotoxicity. Higher concentrations of ouabain (500.0 μM) offered no protection. The mouse sciatic nerve preparation is a simple and low-cost bioassay that can be used to assess and quantify the neurotoxic effects of standard PlTX or PlTX-like compounds, since it appears to have the same sensitivity as the haemolysis of erythrocytes assay--the standard ex vivo test for PlTX toxicity. Copyright © 2012 Elsevier Ltd. All rights reserved.

Study of the Microwave Response of Sea Ice

DTIC Science & Technology

1991-12-01

may be used to improve the determination of ice thickness for sea ice cases below 1 m . 3 * Millimeter-wave measurements have been added to the...70" T a b le 2 . RS O -01 R? UPPER ICE SHEET CHARACTERIZATIONS Di-- D.-. 0 10. Silo aa..n-l a. M L0400 1 2 0017.4. 1746.... S.I.7Ol y Onnbsy M ... 0...t4b 0744.. VOO 0h 6n0... Ssllad 0... U...ll .4 4. M .,W 000I I.0* 1 0.700.12 3.0.5 0.6 2.1 0.673 60 03 4.9,03 0.3 0.074 00 0.0 L0 .40n 4 0.23t005 3-00.3

Prime Contractors with Awards Over $25,000 by Name, Location, and Contract Number, Fiscal Year 1992 (Bituminous Paving, Inc.-Datum Maching Services, Inc.)

DTIC Science & Technology

1993-01-01

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Alpha List of Prime Contract Awards. Oct 91 - Sep 92. FY 92. (Mill Distributors Inc - North Bay Contracting)

DTIC Science & Technology

1993-01-01

4 m Cl) (1) a-4-4 (D C4 el im E~-ZN 0 0 -4 m IM mnif-4p0 to 410 0)N" 3 WWLIJ.1- a 0 0 0 0C00, 0C00. 0N 0-4-4 a > 2 Z -II 0-4o a ILI in1 a 000i N 2 2...4440 4I- 4(0 aN 4(0 LL 4(Z0IU A w N 04 I (0ON 442 ac 44~II4--. de wZZ~ ~ w2 . w( w0 w: CA: - Ř- 4. ( 00-4 9 4 w i w t 4 4-41(00 a-4 _j4 4 i-i - j j...0 0 0 0L U Imo 000 Ul NNNN N N V -IN NN N NN N N1 N W I WO0N U 0 0 U) a 1 0040N N 0 j0 de It 00 I ID 01- < 0 -C 0 4c ម coo lia 32 I.- I-. - a. I

USACERL Report Bibliography.

DTIC Science & Technology

1980-12-01

LV h3ct m- C a10 L EE Z 0 to 000 0 0 I0Z4 4-- 0J U. >4j n -o tt Cr C. )04: OtD L. 0 . 0. --o 0A 0 10 t- t- - 4- >_ xAt) 0 0 40 > go~ 100 U C>. -- 4...0 C in*>Q -1 a)11 10-) 0 MU- ’o -1 0 . 0W 0- - - -a O C S CC _ U b C. o - 0 - 0 0 -In - C 100 V.01 0 01 -e !- -)to t o 4 L 00~’ t-0 01 101 10 In W...L -A 10 0 (0 c. 0n 4- U) 04 L OV 2 100 4)5 0M 1 - 0 ’s- C- < m 0) 04) mC 0 - C . CLSV 0-> (n >4 (0 0 -- U 40C . ZC L -01 0 .-- W . 0. VE 0~ lb 4) 00 Q

The formation and effect of outer-ply microcracks in cross-ply laminates - A variational approach

NASA Technical Reports Server (NTRS)

Nairn, John A.; Hu, Shoufeng

1992-01-01

The paper presents a variational mechanics analysis of the stresses and energy release rate in a (90m/0n)s laminate, with account taken of the observed existence of staggered microcracks. It is found that the load required to initiate microcracks is significantly lower for (90m/0n)s laminates than for (0n/90m)s laminates. It is also found that (90m/0n)s laminates are characterized by a lower saturation crack density and that no bending effects tend to promote mode I delamination in (90m/0n)s laminates.

HAT-TR-318-007: A Double-lined M Dwarf Binary with Total Secondary Eclipses Discovered by HATNet and Observed by K2

NASA Astrophysics Data System (ADS)

Hartman, J. D.; Quinn, S. N.; Bakos, G. Á.; Torres, G.; Kovács, G.; Latham, D. W.; Noyes, R. W.; Shporer, A.; Fulton, B. J.; Esquerdo, G. A.; Everett, M. E.; Penev, K.; Bhatti, W.; Csubry, Z.

2018-03-01

We report the discovery by the HATNet survey of HAT-TR-318-007, a P=3.34395390+/- 0.00000020 day period detached double-lined M dwarf binary with total secondary eclipses. We combine radial velocity (RV) measurements from TRES/FLWO 1.5 m and time-series photometry from HATNet, FLWO 1.2 m, BOS 0.8 m, and NASA K2 Campaign 5, to determine the masses and radii of the component stars: MA=0.448+/-0.011 M⊙N, MB=0.2721-0.0042+0.0041 M⊙N, RA=0.4548-0.0036+0.0035 R⊙N, and RB=0.2913-0.0024+0.0023 R⊙N. We obtained a FIRE/Magellan near-infrared spectrum of the primary star during a total secondary eclipse, and we use this to obtain disentangled spectra of both components. We determine spectral types of STA=M 3.71+/- 0.69 and STB=M 5.01+/- 0.73 and effective temperatures of Teff, A= 3190+/-110 K and Teff, B=3100+/- 110 K for the primary and secondary star, respectively. We also measure a metallicity of [Fe/H] = +0.298+/- 0.080 for the system. We find that the system has a small, but significant, nonzero eccentricity of 0.0136+/- 0.0026. The K2 light curve shows a coherent variation at a period of 3.41315-0.00032+0.00030 days, which is slightly longer than the orbital period, and which we demonstrate comes from the primary star. We interpret this as the rotation period of the primary. We perform a quantitative comparison between the Dartmouth stellar evolution models and the seven systems, including HAT-TR-318-007, that contain M dwarfs with 0.2 M⊙N< M< 0.5 M⊙N, have metallicity measurements, and have masses and radii determined to better than 5% precision. Discrepancies between the predicted and observed masses and radii are found for three of the systems.

All Prime Contract Awards by State or Country, Place, and Contractor, FY 85. Part 15 (Altus, Oklahoma - Zelienople, Pennsylvania).

DTIC Science & Technology

1985-01-01

Iso CM I m -4 0N 4 MNNNNNN"N-4-4 aN ION w O 40 UNNN liN 40.4 4 OR 60 4 14 .-4 -4 ..4 -4f -4 I-’ 1 0 0 0 0 0 0 0 0 0 -i aJC 0 4 1 4 i q--4-4--4 -- 4...4 azo azo ixN 0 .0 woo 000 0zo 01( C’) -I .4 0i~o x-0 0 4 N - ((0 04 03(0 ()I 1 -0 -4 0~00 x -0 0 04 " .(A 0 04 0.0 .4 0’( 4C I m i 41013 ə 3tr irn

A role for Na+/H+ exchange in contraction of guinea pig airways by endothelin-1 in vitro.

PubMed

Battistini, B; Filep, J G; Cragoe, E J; Fournier, A; Sirois, P

1991-03-15

Endothelin-1-induced contractions of guinea pig tracheal and bronchial strips were dose-dependently attenuated by the amiloride analogues 5-(N-ethyl-N-isopropyl)amiloride (EIPA, 1-10 microM) and 5-(N,N-hexamethylene)amiloride (HMA, 1-10 microM). The calculated Ki values for EIPA and HMA were 0.11 +/- 0.02 microM and 0.06 +/- 0.02 microM in the trachea, and 0.28 +/- 0.11 microM and 0.70 +/- 0.25 microM in the bronchus, respectively. These values are in the same order of magnitude as those reported for inhibition of the Na+/H+ exchange in cells. Amiloride (1-10 microM) was ineffective. These data suggest that activation of the Na+/H+ exchange by ET-1 may be involved in mediating its myotropic action in guinea pig airway smooth muscle.

Prime Contract Awards by State or Country, Place and Contractor. Part 11 (Gibbsboro Air Force Station, New Jersey - Peekskill, New York), FY1991

DTIC Science & Technology

1991-01-01

MO enC mC mmOmm CIS m 4’ ’)04 I.0 -0 -o 4 -0 00 00 00 0> o * I (CI)0 W ro- 141-1 Il--- w441- 11- 4.1- t4-- - 441r-1- UII- 1- 41 ~ IS 0 4400 to 1- r...it EM’N-4-4m’-I-IN ENc , EN ENc EON E -4 E --- Ec’) E-1 toI -4 M- 04 I C’(000)’)r-q 0-0 ON 000 O-4in 000 O0 0 I 0-4 Ofr-- 0 Ki C.. 04 K 1000-0 V)0 (n 00...C--(0c’ 01" CI w .I. 10 .4 I 02-4 Nf (Ion (0 W((0(u’)-4mww -z0 > 03 II-4 1I 02-4 If Z-I 4 W-1)IN(N"r-000C’) w0 o Nf 𔃺 1 M2-4 N" W-S LaDO -4-4 -4 4 4

Department of the Navy Justification of Estimates for Fiscal Year 1988/1989 Submitted to Congress. Operation & Maintenance, Marine Corps.

DTIC Science & Technology

1987-01-01

N $0 4 >U4. .v i 104 00 0 00 w 4) 0 :3 N r.’U -r4 0 0400 9~~ 0 (a~ ~!k= 4- w A = :3 ki td 0 l i C4In 0 m 0-4 0 NQ m m Qo o mL q~ rr-4m Q v N . 4... 4bd IV 4 a 0 k 6- u* ’ 44 0% 4 h hi Ř 0 -4 Ř 0 V’ wi *4 6 600. J a 0 $4 41 4 Q P4 6k Ca at%~ 640 4 hi � ki -4 4 $i F’ 6 4 .0 41-4 M, 0 % 4 +i c...34444 V) 9; H 𔃺 4.) W r1) 0 go 02 V4 02 *4 4)0 0 g 𔃺 𔃺 -’-4 H 0 0 - > 41 0~ 4) 0d 0 0 0 $4 (A0 .02 td 0 r * r q la0 . 10 rd 4H 04 4 .) v . 4. u.’ 50

An ultrasound evaluation of laryngeal mask airway position in pediatric patients: an observational study.

PubMed

Kim, Jeongmin; Kim, Ji Young; Kim, Won Oak; Kil, Hae Keum

2015-02-01

In children, the laryngeal mask airway (LMA) is frequently displaced within the hypopharynx, resulting in repositioning of the device. When the tip of the LMA is placed in the esophageal inlet, the arytenoids are moved ventrally. When the LMA is rotated or deviated, the ventral movement of the arytenoids may result in asymmetric elevation of an arytenoid cartilage, which can be detected with ultrasound (US). In this study, we sought to estimate the incidence of LMA malposition detected with US in pediatric patients. The primary end point was to compare the incidence of LMA malposition between US and fiber optic bronchoscopy (FOB). The secondary end points were to find the interrelationship between US-detected and FOB-detected malposition of the LMA and to locate the diagnostic performance of US in detecting LMA malposition. In this observational study, 100 consecutive children were included. After anesthetic induction, US evaluation was performed before and after LMA insertion to obtain the glottic image on the anterior neck. FOB was performed to assess LMA position (FOB LMA grade and LMA rotation grade). With a post-LMA US image, the symmetry of the arytenoid cartilages was evaluated. Asymmetrical elevation of an arytenoid cartilage in reference to the glottic midline and the opposite arytenoid cartilage was graded as 0 to 3 (US arytenoid grade). The interrelationships between US arytenoid grade and FOB LMA grade or LMA rotation grade were assessed. The incidence of asymmetrical elevation of an arytenoid was 50% (95% confidence interval [CI], 40%-60%). On FOB, the incidence of LMA malposition was 78% (95% CI, 69%-86%), and that of LMA rotation was 43% (95% CI, 33%-53%). The incidence of LMA malposition was higher with FOB (P < 0.0001), but the incidence of rotation was similar (P = 0.395). US arytenoid grade did not correlate with FOB LMA grade (P = 0.611) but showed a significant correlation with LMA rotation grade (P < 0.0001; 95% CI, 60%-83%). To detect a rotated LMA, US had a sensitivity of 93% (95% CI, 81%-98%) and a specificity of 82% (95% CI, 70%-91%). The positive and negative predictive values were 80% (95% CI, 66%-90%) and 94% (95% CI, 83%-99%), respectively. The accuracy was 87% (95% CI, 79%-93%). Although US could not detect the suboptimal depth of an LMA, US has promise of being an accurate tool in detecting a rotated LMA.

All Prime Contract Awards by State or Country, Place, and Contractor, FY 87. Part 10. Aberdeen, Maryland-Woodbine, Maryland.

DTIC Science & Technology

1987-01-01

NAME OF FUNDING/SPONSORING 8b. OFFICE SYMBOL 9 . PROCUREMENT INSTRUMENT IDENTIFICATION NUMBER ORGANIZATION (If applicable) Bc. ADDRESS (City, State...8217.io 000 0 00 01: 4 ,4.100000000000000000 4 10 20 ZO 000Q cc0 Z0 0 ’ 14 C,4-J0000000000000000000 9 < ɜ "ə 4< "ɜ ".x4 In4 L) 444 0 < -J.0 0 KO:x Z (D...o( .i.- 04M 5- 3I- ap 3- (V) 00) 40 0- 9 ) m .v-C 1I 0 0 0 0 N N N N N N MOO< 1 l -4-4O~ 0.-I -4 0N 0 (.-L4W-4 0-N D -N 0-NI <I v-4- oo- 4- - "- p ᝰ

EM61 MkII Transect Demonstration at Former Camp Beale Technology Demonstration Data Report

DTIC Science & Technology

2007-07-12

td . d ev ., m ) 0.000 0.002 0.004...07 17 20 01 07 17 30 01 A ve ra ge E M 61 M kI I S 1 V ar ia tio n (s td . d ev ., m V ) 0.0 0.5 1.0 1.5 2.0 2.5 Mean = 1.16 mV 1σ = 0.51 mV...32 00 7_ 14 26 15 Ju l0 52 00 7_ 17 38 03 Ju l0 62 00 7_ 16 51 50 2- D p os iti on al v ar ia tio n (s td . d ev ., m ) 0.000 0.005 0.010

All Prime Contract Awards by State or Country, Place, and Contractor, FY 87. Part 9. Abilene, Kansas-Yarmouth, Maine.

DTIC Science & Technology

1987-01-01

8217) 00) 00() W-4 4I 0C04 I CNNeNN".40 c.-4 c N C-4 cO -.4-40 C.40(co0~ C(O C.-4 C.4 C-4 I 00 I C-.4-4" "N 4c c .4 CN C O c ENc C-4-4< C.4-I.44C c - C-I C...34-N 04 >4 w 0 w104 -4 𔃾 1 (0O04 I E -4.4 -4,4< E-4 -4 4 EC’m ENc E -4 EN U MN m 00 .CD ’-4 CN4 = N 1I (O0004 W WW M ID~(0o WC~o .C4 .CI =(L =CC, us N...4000C4 0-44 0 0 0004 ’)n . enc (j -0 c0 0 7 3(0029 000- 00-44--C Z(co1-10- 4 0 4. 00001-< 0- 0q 0Nca co 0c 0 0m~ 00 00rc . nwu> UM )mmc 10 4 (. o r)00

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, FY 88. Part 11. (International Corporation-La Ronda)

DTIC Science & Technology

1988-01-01

0 0 cau ( 5 . 4A 0 . d) - W 0 4Ao 0 C00 C -4 43 CL ..4 430 o m 0 ... 0 - CL- W 4 3 U 0 0c- 0 CI 0 -4 m. 43. 03 4 5 . 0 00 ’. C 43 S -4 Sn aW ’- 4 0 4 . 0 < _4 0 4w E E -4 - 06 M4 mW cc 5 . 0 4W .o . 0 2~. ~ c .= 0 >1 0 E3 2... 0 0 003 N, *- to C) 0 N4 U 4 -% -m U 0 -4 .-.4 3 C 4 -40 0

Crystal structure and optical property of complex perovskite oxynitrides ALi0.2Nb0.8O2.8N0.2, ANa0.2Nb0.8O2.8N0.2, and AMg0.2Nb0.8O2.6N0.4 (A = Sr, Ba)

NASA Astrophysics Data System (ADS)

Moon, Keon Ho; Avdeev, Maxim; Kim, Young-Il

2017-10-01

Oxynitride type complex perovskites AM0.2Nb0.8O3-xNx (A = Sr, Ba; M = Li, Na, Mg) were newly synthesized by the solid state diffusion of Li+, Na+, or Mg2+ into the layered oxide, A5Nb4O15, with concurrent O/N substitution. Neutron and synchrotron X-ray Rietveld refinement showed that SrLi0.2Nb0.8O2.8N0.2, SrNa0.2Nb0.8O2.8N0.2, and SrMg0.2Nb0.8O2.6N0.4 had body-centered tetragonal symmetry (I4/mcm), while those with A = Ba had simple cubic symmetry (Pm 3 ̅ m). In the tetragonal Sr-compounds, the nitrogen atoms were localized on the c-axial 4a site. However, the octahedral cations, M/Nb (M = Li, Na, Mg) were distributed randomly in all six compounds. The lattice volume of AM0.2Nb0.8O3-xNx was dependent on various factors including the type of A and the electronegativity of M. Compared to the simple perovskites, ANbO2N (A = Sr, Ba), AM0.2Nb0.8O3-xNx had wider band gaps (1.76-2.15 eV for A = Sr and 1.65-2.10 eV for A = Ba), but significantly lower sub-gap absorption.

Projections of Demand for Waterborne Transportation, Ohio River Basin, 1980, 1990, 2000, 2020, 2040. Volume 9. Group VII. Ores and Minerals.

DTIC Science & Technology

1980-12-01

U l 0 0 ) C 4140 c4 34jE 04 0)t 03.- In lo No ID 0ID 6)ID M). U 0 ( in cc m m m c m mm m a a) la.0u) 0r- 02d)20 C ’N C ~ 3 C -27- c -o 0 It14’ 0 14 tn...N 1.D/ c4 0)00E w.~ 0 V-- -"- -- V04 M1)4VdW -4I -..- 1. 0001M.-40 00 4D4J.’ ::l c:; Q o u00 0 0.0 a 0~~ ~ m𔃺 w , 0-0m.-Q)uH 1.4 0 : . 0 4140 .0 ZZl...Statistical Report. 1969-78 eds. Washington, D.C.: AISI , 1970-79. American Metal Market. Metal Statistics. 1970 -d. New York: Fairchild, 1976. "Facts and

Design and Real-Time Implementation of a Baseband LPC Coder for Speech Transmission over 9600 BPS Noisy Channels. Volume II. Programming Listings.

DTIC Science & Technology

1980-02-01

cwc N (w~ mm. IDmm m w. C. msite &C-ew %a~m MCI I Di . m1a.2 ,% v oa m.1] W.k1i . . 13.M mmm r, q.W.3.44. I&1242 %D2 1.J1 M.1. ItP a b nNM - f .M2 47 4...a a a a a.a a.a0 IBM a aa a11,11 a .0 a1 . U q M4 MS K IaI u C% A4 U u0 1. w4 . N MKV Ia IO1 U a,". 44 4 .4 N m N N N N N6 N N N (M M M M U M M M CD

The Air Force Manual for Design and Analysis of Hardened Structures

DTIC Science & Technology

1974-10-01

PHOTOGRAPH THIS SHEET 71H(Z7 FO IC-~ M A AluA4 Fe 41, 00 Ai -A. 55 0LEVEL INVENTORY Lf) DOCUMENT IDENTIFICATION ~UIMON STRTEMENT A Approvd for public...aU0 t SiE =~ E.4 04 5 0U U . 5 44 N A-4 o. 0- 4 A) (4 0 0 el 0% 0> -0 04 00 ’. 0 0 t0 0* (4 Aj 0 0 .4 4 A5 b4 .4 aN 55 k U CH W VVo 01 M M M M M M M...0 𔃿 40. 0%. u) a 0 a 14) "j0-4Aj% w L 0. 4 ao 4) ’a :.~ -c 1jŔ 14 04 1 0 ) t404 04) 4: U3 0 0444) -.4 0.’ 55 10 u4 - 0 4) 1. ) c) U .C. U 0~ 0 w 0

In vitro desensitization of beta-adrenoceptors in guinea pig trachea: interactions between beta-adrenoceptor agonists and influence of adenosine and other drugs.

PubMed

Matran, R; Naline, E; Advenier, C; Duroux, P

1989-01-01

The aim of this study was to investigate quantitatively the action of and the interaction between beta-adrenergic receptor agonists in desensitizing guinea pig isolated trachea. It was also to evaluate the influence of substances whose effects on desensitization are either disputed (theophylline, indomethacin, ketotifen, hydrocortisone) or unknown (nicardipine, Bay K 8644, fenspiride, adenosine). Tracheal strips were contracted with histamine (5 x 10(-5) M) or acetylcholine (5.10(-5) M) and concentration-response (C/R) curves for various beta-adrenoceptor agonists were determined before and after incubation (20 min to 4 h) with the same beta-adrenoceptor agonist (autodesensitization), with other beta-adrenoceptor agonists (cross-desensitization), or with a beta-adrenoceptor agonist and another substance. Our results show that the autodesensitization induced by isoprenaline is concentration dependent and that concentration dependence is more pronounced with salbutamol and fenoterol than with isoprenaline and adrenaline with respect to autodesensitization: shifts (log unit) of the C/R curves were 0.59 +/- 0.06 (N = 5) for salbutamol (10(-5) M), 0.78 +/- 0.09 (N = 5) for fenoterol (10(-6) M), 0.30 +/- 0.04 (N = 9) for isoprenaline (10(-5) M), and 0.33 +/- 0.05 (N = 5) for adrenaline (10(-5) M). Our studies of cross-desensitization (desensitization to isoprenaline, adrenaline, salbutamol, and fenoterol induced by incubation with isoprenaline 10(-5) M) showed a significantly greater shift in the C/R curves for fenoterol (0.56 +/- 0.08, N = 5) and salbutamol (0.62 +/- 0.05, N = 5) than for adrenaline (0.35 +/- 0.07, N = 5) and isoprenaline itself (0.30 +/- 0.05, N = 9). Of the substances we studied, none modified the desensitization induced by isoprenaline except hydrocortisone and adenosine. Hydrocortisone (10(-8) M) reduced it significantly, although to a negligible extent. Adenosine (3 x 10(-4) M) did not shift the C/R curve to isoprenaline by itself, but incubation of tracheal strips with adenosine and isoprenaline caused a significantly greater shift of C/R curves to isoprenaline (0.30 +/- 0.04) than incubation with isoprenaline alone (0.20 +/- 0.04) (P less than 0.05, N = 5). These experiments suggest that adenosine may have increased the uncoupling and/or down-regulation phenomena induced by isoprenaline, or modified adenylate cyclase-cAMP activity.

Dual effects of ouabain on the regulation of proliferation and apoptosis in human umbilical vein endothelial cells: involvement of Na(+)-K(+)-ATPase α-subunits and NF-κB.

PubMed

Ren, Yan-Ping; Zhang, Ming-Juan; Zhang, Ting; Huang, Ruo-Wen

2014-01-01

To elucidate the effect of ouabain on the regulation of proliferation and apoptosis of HUVECs and involvement of different Na(+)-K(+)-ATPase α-subunits and NF-κB. HUVECs were isolated by collagenase perfusion, and MTT assays and cell cycle analysis were performed to study proliferation. NF-κB expression and function were examined by immunohistochemical staining and western blotting. Na(+)-K(+)-ATPase activity was determined by measuring released ouabain inhibitable inorganic phosphate (Pi). The expression of different α-subunits was investigated by real RT-PCR, western blotting and cell immunofluorescence. 0.3 nM ouabain treatment for 0.5 h triggered the proliferation of HUVECs, peaking at 1-2 h. At 1.8 nM for 0.5 h, ouabain induced an increase of cell proliferation for a short time, and then triggered a decrease after 1 h. Cell cycle analysis show that 37% of HUVECs were in G2/M phase of the cell cycle following incubation with 1.8 nM ouabain, compared with 18% with 0.3 nM ouabain. NF-κB activity was assessed by western blot analysis of IκB expression, which was significantly reduced with 0.3 nM ouabain treatment; there was no different between 1.8 nM ouabain treatment and untreated cells. Na(+)-K(+)-ATPase activity in HUVECs was markedly reduced after treatment with 0.3 nM and 1.8 nM ouabain. Real RT-PCR and western blotting indicated that Na(+)-K(+)-ATPase α1-subunit mRNA expression levels increased after 0.3 nM ouabain treatment and decreased after 1.8 nM ouabain treatment. However, α2- and α3-subunit mRNA decreased after 0.3 nM ouabain treatment and increased after 1.8 nM ouabain treatment. Ouabain at different concentrations caused dual effects on proliferation and apoptosis in HUVECs.

Does tumour location influence postoperative long-term survival in patients with oesophageal squamous cell carcinoma?

PubMed

Shi, Hui; Zhang, Kun; Niu, Zhong-Xi; Wang, Wen-Ping; Gao, Qiang; Chen, Long-Qi

2015-08-01

The seventh edition of the American Joint Committee on Cancer (AJCC) staging system introduced tumour location for the first time as an determinant of stage grouping in pathological T2N0M0 and T3N0M0 (pT2-3N0M0) oesophageal squamous cell carcinoma (OSCC). However, the new modification remains controversial. The objective of this study was to investigate the correlation between tumour location and postoperative long-term survival in patients with OSCC in China. The clinicopathological data and over 10 years of follow-up results from a large cohort of 988 patients with OSCC undergoing radical-intent oesophagectomy from 1984 to 1995 without preoperative and postoperative chemoradiotherapy were reviewed, in which 632 patients were staged as pT2-3N0M0. Tumour location was redefined according to the seventh edition of the AJCC staging system. Survival was calculated by the Kaplan-Meier method; univariate log-rank and multivariate Cox proportional hazard models were used to further determine the impact of tumour location on long-term survival. Univariate analysis showed that OSCC tumour location was closely associated with long-term survival for the entire cohort of 988 patients (odds ratio [OR]: 0.82; 95% confidence interval [95% CI]: 0.67-0.99; P = 0.049), and for pT2-3N0M0 patients (OR: 0.63; 95% CI: 0.48-0.84; P = 0.001). The median survival times for patients with pT2-3N0M0 OSCC in the upper, middle and lower third of the oesophagus were 38.1, 46.6 and 66.0 months, respectively, with corresponding 5-year survival rates of 40.0, 51.8 and 66.2%, respectively. Overall survival rates among three categories of patients according to tumour location in the pT2-3N0M0 patients were statistically different (P = 0.004). Multivariate analysis demonstrated that tumour location was a significant independent predictor of long-term survival for pT2-3N0M0 patients (OR: 0.53; 95% CI: 0.42-0.67; P = 0.0001), but not for the entire cohort of 988 patients (OR: 0.99; 95% CI: 0.79-1.23; P = 0.90). Tumour location is an independent predictor of long-term survival for pathological T2-3N0M0 OSCC, and should be incorporated into the current staging system to predict long-term survival and identify high-risk postoperative patients. © The Author 2015. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.

Prime Contract Awards over $25,000 by State, City, and Contractor. Fiscal Year 1993 (Oct-Sep). (Alachua, Florida-Wreniham, Mass.). Part 2

DTIC Science & Technology

1994-03-01

m W m = w m W < w CI OWL W=>a W Z W C~ :- au-Cc!. 4J -J-- f u m - o uwaU U CL I a 4<c c0Z O O -- W W o = = w w U W W W O C 4w zaw a U UJ Wj x l- W c...w ca Z CL 4 40) w% OO) L LL100M ZO)! % w4~ ~~~~ 0100 u :x I.-N -i I 0 4c OU N NC4cn4 )C 41a 0 CA w4 I- N< .4 ON =~~ N Ni ɘ" Ul tUn .4 "=-- N.-i N 0...8217 ca (in u m 0C c j V u I-IAU~no ý X~< "I-x 4a o0 - A 00 *’-> ao mýO 000 u DC .4" L)LIL 9 -4 0> 0-.-z t.- zaW WO U--aý U UO WL OL a4(D WýXaý anýO m tx

Department of the Navy Justification of Estimates FY 1992/FY 1992 Budget Estimates Submitted to Congress February 1991, Operation and Maintenance, Navy. Book 2.

DTIC Science & Technology

1991-02-01

LLI LALI IU - >~ -j w -. .. z ., . Iz - m < LLLI LL . 1 -j 01L oo= CC 0 z U.. 14) rowLI w a UmU..0 961V 9ZV--I e0ohozi in 1 01 1 00,01r0...n.&...en e...0 N . 0n a. f. O aj,, 0 t i..a n 4It . en *.i ci I! 1 .e r: 1di.. 0C-cr40 n t110 Il -o mni. -W w 42 n~r 0,’. nir w 𔃺 U 01 10 000000 0 - n 0.c in-e ..4...i in M -i I’i -4. Nt oia 011 0 0 0 0 1 4 I n ,e O 0 0 0 0 0 = 0 O10e e00 0.00 1 0 .. ..00 1 10 0, n 0 0 0 r aeiei..i1er in 10Non N-n0..4, 0010 z n

Prime Contract Awards Alphabetically by Contractor, State or Country, and Place. Part 15 (Roofmasters Inc, Texarkana, Texas - South Dakota School of Mines and Technology, Rapid City, South Dakota), FY1991

DTIC Science & Technology

1991-01-01

5 -4 N 0I O N a* 0 ( 4c a* 00 " 1-NN N N N N N N N C4( (00 4C4.. ICC4.. 4CJ0 000 00 CL 0 . I CO ( ( - 0 4 0 > -4 0 -4-4-4-4...C 40 0 mm 44 0 Q Q CO 4x ca O1 0 H 44 C4 Um mmO CD m0c oO 5 OC K O 0 -4 0 H U ’ CD O 0 o o 0a) 0 )- 0 )- 0D - OZ C, 0 K .ici IV <KCC’ g H I 0 -4INO H 0 ...INN- ") 0 -n - M44 -4-4 -4 C’) H4 1 MWO If0 ( -4) to -40 40 c 44 00 - 0 *-

Predictability of Burn Depth: Data Analysis and Mathematical Modeling Based on USAARL’s Experimental Porcine Burn Data

DTIC Science & Technology

1979-06-01

7C70 -9. PERFORMING ORGANIZATION NAME AND ADDRESS I ,.qgq-’ " Louisiana State University Medical Center, School AE OKUI UBR of Medlicine in Shreveport...induced shrinkage while more superficial burns showed some edema and swelling. The edema and swell- ing was slight, approximately 3-5%, and not as...biopsy specimen. 14 4)- E-4 tn %0 LA -0 (mVC 0 N %n ~ N- .0L0 oMu 0 I 1 4’ C, 0, A A L 0 0) 0, o 0 z P ~ - 4 N -0 m 0 0 0 0n 0 E-4 v 04 to ~0 E-4z Gi 0

/sup 3/H-PAF-acether displacement and inhibition of binding in intact human platelets by BN 52021

DOE Office of Scientific and Technical Information (OSTI.GOV)

Korth, R.; Le Couedic, J.P.; Benveniste, J.

1986-03-05

Intact washed human platelets incubated at 20/sup 0/C in Tyrode's buffer containing 0.25% (w/v) bovine serum albumin bound /sup 3/H paf-acether in a concentration (0-6.5 nM) and time (0-60 min) dependent manner (n=3). BN 52021 (60 ..mu..M) a chemically defined extract from Ginkgo biloba inhibited the binding of increasing concentrations of /sup 3/H paf-acether. Calculated differences between /sup 3/H paf-acether binding in the presence or absence of BN 52021 (60 ..mu..M) reached nearly a plateau in concentrations higher than 0.65 nM /sup 3/H paf-acether. Increasing concentrations of BN 52021 (0-60 ..mu..M) as well as of unlabelled paf-acether (0-50 nM) preventedmore » within 15 min /sup 3/H paf-acether binding (0.65 nM) to platelets in a concentration-dependent way. Increasing BN 52021 concentrations (0-60 ..mu..M) also displaced platelet-bound /sup 3/H paf-acether (0.65 nM) in a concentration-dependent way. Displacement increased with the time length of platelet incubation with BN 52021 and reached a plateau at 15 min. Platelet-bound /sup 3/H paf-acether displacement of 28.3 +/- 6.3%, 31.1 +/- 4.0% and 26.7 +/- 5.6% was observed using 50 nM unlabelled paf-acether, 60 ..mu..M BN 52021 or both substances together (vs 4.3 +/- 7.2% for vehicle alone). No degradation of /sup 3/H paf-acether occurred as assessed by high pressure liquid chromatography. These results demonstrate that BN 52021 competes directly with paf-acether binding sites on human platelets.« less

Acoustic Correlates of Compensatory Adjustments to the Glottic and Supraglottic Structures in Patients with Unilateral Vocal Fold Paralysis

PubMed Central

2015-01-01

The goal of this study was to analyse perceptually and acoustically the voices of patients with Unilateral Vocal Fold Paralysis (UVFP) and compare them to the voices of normal subjects. These voices were analysed perceptually with the GRBAS scale and acoustically using the following parameters: mean fundamental frequency (F0), standard-deviation of F0, jitter (ppq5), shimmer (apq11), mean harmonics-to-noise ratio (HNR), mean first (F1) and second (F2) formants frequency, and standard-deviation of F1 and F2 frequencies. Statistically significant differences were found in all of the perceptual parameters. Also the jitter, shimmer, HNR, standard-deviation of F0, and standard-deviation of the frequency of F2 were statistically different between groups, for both genders. In the male data differences were also found in F1 and F2 frequencies values and in the standard-deviation of the frequency of F1. This study allowed the documentation of the alterations resulting from UVFP and addressed the exploration of parameters with limited information for this pathology. PMID:26557690

Computation of the Percentage Points of the Chi-Square Distribution

DTIC Science & Technology

1977-04-01

0D.4 ’ 2th cW%(F. ffA ’*. .0 Dp 46 v Ne #% N’ c %c 0% rmsn",0a0r fWN ..an W% *SA%0 0 9. M do Q at Ge .4.4 ~N P) ) AIII0 t- t.. 40 so(PO cC3.4..4 W N...0V %0, n:U ( bbP P xv 0-.V~ Pa bONP . CY R. .4 1 6 6 6. 6 6 6 6 6S * 6 6 6 6 6 6 6 6 6 6 6 6 6 . 6 . . 6 6 6 6 6 WS- mom4 .0f 0 M4SA on a~ 4tq .4~b M

Reactions of N2O5 with Salty and Surfactant-Coated Glycerol: Interfacial Conversion of Br- to Br2 Mediated by Alkylammonium Cations.

PubMed

Shaloski, Michael A; Gord, Joseph R; Staudt, Sean; Quinn, Sarah L; Bertram, Timothy H; Nathanson, Gilbert M

2017-05-18

Gas-liquid scattering and product-yield experiments are used to investigate reactions of N 2 O 5 with glycerol containing Br - and surfactant ions. N 2 O 5 oxidizes Br - to Br 2 for every solution tested: 2.7 M NaBr, 0.03 M tetrahexylammonium bromide (THABr), 0.03 M THABr + 0.5 M NaBr, 0.03 M THABr + 0.5 M NaCl, 0.03 M THABr + 0.01 M sodium dodecyl sulfate (SDS), and 0.01 M cetyltrimethylammonium bromide (CTABr). N 2 O 5 also reacts with glycerol itself to produce mono- and dinitroglycerin. Surface tension measurements indicate that 0.03 M THABr and 2.7 M NaBr have similar interfacial Br - concentrations, though their bulk Br - concentrations differ by 90-fold. We find that twice as much Br 2 is produced in the presence of THA + , implying that the conversion of Br - to Br 2 is initiated at the interface, perhaps mediated by the charged, hydrophobic pocket within the surface THA + cation. The addition of 0.5 M NaBr, 0.5 M NaCl, or 0.01 M SDS to 0.03 M THABr lowers the Br 2 production rate by 23%, 63%, and 67% of the THABr value, respectively. When CTA + is substituted for THA + , Br 2 production drops to 12% of the THABr value. The generation of Br 2 under such different conditions implies that trace amounts of surface-active alkylammonium ions can catalyze interfacial N 2 O 5 reactions, even when salts and other surfactants are present.

Quality of life and voice assessment in patients with early-stage glottic cancer.

PubMed

Arias, Fernando; Arraras, Juan Ignacio; Asin, Gemma; Uzcanga, María Itziar; Maraví, Enrique; Chicata, Volker; Eito, Clara; Zarandona, Uxue; Mora, Itxaso; Vila, Meritxell; Domínguez, Miguel Angel

2015-03-01

The purpose of this study was to assess the quality of life (QOL) and voice handicap in a sample of disease-free patients who had been treated at our center with radiotherapy (RT) or surgery for early glottic cancer. QOL and voice handicap were assessed using the European Organisation for Research and Treatment of Cancer (EORTC) questionnaires Quality of Life Questionnaire-Core 30-questions (QLQ-C30) and Quality of Life Questionnaire-Head and Neck 35-questions (QLQ-H&N35) and the Voice Handicap Index (VHI). Ninety-one patients completed the questionnaires. Fifty-nine patients (65%) were treated with RT and 32 (35%) with surgery. QOL scores for the sample recorded, moderate limitations in 6 areas, and more than moderate limitations (>30 of 100) in 2 areas. Significant differences were found in emotional functioning (88.5 vs 76.6) and social contact (4.6 vs 12.1) on the EORTC questionnaires and on the VHI (6.1 vs 12.8), which favored the RT group. In this cross-sectional study, voice quality, emotional functioning, and social contact were better in the RT group. © 2014 Wiley Periodicals, Inc.

Effect of Noise in the Three-Parameter Logistic Model.

DTIC Science & Technology

1982-12-25

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Alpha List of Prime Contract Awards. Oct 92-Sep 93. FY93. (Daychem Laboratories Inc. - Elbeck Enterprises Inc.). Part 6

DTIC Science & Technology

1994-03-01

OIO I UI I 0)N N >44M ..J00..j -J - A5 -.5 .J .80K a 0 (A z InO U0 -4 4 x 1 oc 0)O m )-...J..0 La.0 w. w. w. U3OO 1Ŕ 4 0 wKO 000 0 LiN I COON N...O)->- 1* as o i >_ 30aa aao o aa a )1)-1. >a1 1 * ICON : Nr a O 04 ZZZZZZZZZZZZZZ Z ZZZZZZZZZZZZZZZzmZ Z ZC 0i 81nw IV 0 0 0 0j~ N 00*iN...004M 11 Z Z Z Z Z Z Z Z Z Z Z ~ Z ZZ Z Z Z Z Z Z Z Z Z Z A5 . 0 0000 If ULU UUU110 U U U UL)UU u u UU ULUUCDU UU u u u u(UU UL)UU UU 0(0(Jou WA H 4 00

Dollar Summary of Prime Contract Awards by Contractor, State or Country, and Place, FY 88. Part 3 (First Holdings Intl, Inc.-Kern Instruments, Inc.).

DTIC Science & Technology

1988-01-01

CM 4 M VfU V0t0*00(0G 00 a. _) j cc( 0( Jr 0w c m to 4 ; nL n ( -4- - -C. 0).4 0000 O. m -4- 000 OI N Nl tD ) .?I i V o - C𔃾 CZ4 I0C4 ." -’ C14 0...27I 00. 00. C. 0A ) 0 z - - .-01 w4 w%~ in 0 0KI cc cc U C r (A 4 S z ( CL (A A (( II -I : l ft w- z- mml mm. . 0 4j m ’ C I I Of-l a w- 2 43 *.4 th

Prime Contract Awards Alphabetically by Contractor, State or Country, and Place. Part 9 (Hewlett Packard Company, Foster City, California - International Bus MCHS Corp, Louisville, Kentucky), FY1991

DTIC Science & Technology

1991-01-01

44 0 4 N in M 4 a amN LU-4 OJ4 00o O-4NNN00 04-7)07 0m ()0) 1-0 U0o -4 mwNO r NO N x QO 000 LU00000W( MOO5 XU0 £000 a. ] - -4 F6 .. .5n -.J4 J.4 mm4...4 NNa0 1-am ~a") Ia 4-. -4 - 4 -*** o Q o o ooQ00o00o--44- 01 D .C 1C w : am 1 C00-4 1 l I co -4 mmiN4f4N- .N 4-4- .4 III aCca 4 aa in 0 n 0 0 0 00...04NNMOCOMO -4-4 -.1 640 IIOf-N4.-0444000.40-..400 <mNOO4-40000000000>C C-4- < Ia 4 0 <C’) Is ZZIW a.LL~a.La. 0.A 60 < 4Ni to I IfO(-0(N40ml0ilOONt’. f6 -4 6

Clinical outcomes of patients with hypothyroidism undergoing percutaneous coronary intervention.

PubMed

Zhang, Ming; Sara, Jaskanwal D S; Matsuzawa, Yasushi; Gharib, Hossein; Bell, Malcolm R; Gulati, Rajiv; Lerman, Lilach O; Lerman, Amir

2016-07-07

The aim of this study was to investigate the association between hypothyroidism and major adverse cardiovascular and cerebral events (MACCE) in patients undergoing percutaneous coronary intervention (PCI). Two thousand four hundred and thirty patients who underwent PCI were included. Subjects were divided into two groups: hypothyroidism (n = 686) defined either as a history of hypothyroidism or thyroid-stimulating hormone (TSH) ≥5.0 mU/mL, and euthyroidism (n = 1744) defined as no history of hypothyroidism and/or 0.3 mU/mL ≤ TSH < 5.0 mU/mL. Patients with hypothyroidism were further categorized as untreated (n = 193), or those taking thyroid replacement therapy (TRT) with adequate replacement (0.3 mU/mL ≤ TSH < 5.0 mU/mL, n = 175) or inadequate replacement (TSH ≥ 5.0 mU/mL, n = 318). Adjusted hazard ratios (HRs) were calculated using Cox proportional hazards models. Median follow-up was 3.0 years (interquartile range, 0.5-7.0). After adjustment for covariates, the risk of MACCE and its constituent parts was higher in patients with hypothyroidism compared with those with euthyroidism (MACCE: HR: 1.28, P = 0.0001; myocardial infarction (MI): HR: 1.25, P = 0.037; heart failure: HR: 1.46, P = 0.004; revascularization: HR: 1.26, P = 0.0008; stroke: HR: 1.62, P = 0.04). Compared with untreated patients or those with inadequate replacement, adequately treated hypothyroid patients had a lower risk of MACCE (HR: 0.69, P = 0.005; HR: 0.78, P = 0.045), cardiac death (HR: 0.43, P = 0.008), MI (HR: 0.50, P = 0.0004; HR: 0.60, P = 0.02), and heart failure (HR: 0.50, P = 0.02; HR: 0.52, P = 0.017). Hypothyroidism is associated with a higher incidence of MACCE compared with euthyroidism in patients undergoing PCI. Maintaining adequate control on TRT is beneficial in preventing MACCE. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2016. For permissions please email: journals.permissions@oup.com.

The role of intraoperative narrow-band imaging in transoral laser microsurgery for early and moderately advanced glottic cancer.

PubMed

Klimza, Hanna; Jackowska, Joanna; Piazza, Cesare; Banaszewski, Jacek; Wierzbicka, Malgorzata

2018-03-01

Trans-oral laser microsurgery is an established technique for the treatment of early and moderately advanced laryngeal cancer. The authors intend to test the usefulness of narrow-band imaging in the intraoperative assessment of the larynx mucosa in terms of specifying surgical margins. Forty-four consecutive T1-T2 glottic cancers treated with trans-oral laser microsurgery Type I-VI cordectomy were presented. Suspected areas (90 samples/44 patients) were biopsied under the guidance of narrow-band imaging and white light and sent for frozen section. Our study revealed that 75 of 90 (83.3%) white light and narrow-band imaging-guided samples were histopathologically positive: 30 (40%) were confirmed as carcinoma in situ or invasive carcinoma and 45 (60%) as moderate to severe dysplasia. In 6 patients mucosa was suspected only in narrow-band imaging, with no suspicion under white light. Thus, in these 6 patients 18/90 (20%) samples were taken. In 5/6 patients 16/18 (88.8%) samples were positive in frozen section: in 6/18 (33.3%) carcinoma (2 patients), 10/18 (66.6%) severe dysplasia was confirmed (3 patients). In 1 patient 2/18 (11.1%) samples were negative in frozen section. Presented analysis showed, that sensitivity, specificity and accuracy of white light was 79.5%, 20% and 71.1% respectively, while narrow-band imaging was 100%, 0.0% and 85.7%, respectively. The intraoperative use of narrow-band imaging proved to be valuable in the visualization of suspect areas of the mucosa. Narrow-band imaging confirms the suspicions undertaken in white light and importantly, it showed microlesions beyond the scope of white light. Copyright © 2018 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. All rights reserved.

All Prime Contract Awards by State or Country, Place, and Contractor. Part 21 (Stafford Virginia-Yellowstone Park)

DTIC Science & Technology

1990-01-01

40000 -loco � 000 00"e00000 a Ir-4 N 4 c 40~C) ,0oe c c C)CV V CV C-i-4 caninannananmwa m wnan W* IC04N4 U Ncv ~f0cv(’)mmma) ’. -4-4-4-4-1 *4NN .0...MC’) U N 40 N C’) Ncv ) 0 -IN ON ON C0 0-44.-I- ON0 : cc 04) U C’) -I 04. OP. NO4.0 0-I N4. I--Cv) Vq44.4..4. 644 m : a 4) -I 00 ao -4.40 M a -40 00...IZ .- JvvvZ IW NCV 8 Nl P.C c’S r 0P r-0 P. P.- 0r 4W5 0>3ON -IN -N OV)N NN O-NN -IN NN OIN ONNNNNNN .8 .c co 04 C4 O( I 04W Nz z z zz z zz z zz z z zz

Candidate Insect Repellent AI3-35713-aGa N-Pentylvaleramide

DTIC Science & Technology

1976-10-19

0 Io -44 0 0 ON . w *0. 4) L0 0 ~ -- 0t, M- N 41 M , y ) *4Ur 0 f E0 4) MN 4) O.* r U 4J404 Ul~ r, eo 0 r. a.O~U f- n AN 1. ) 41$44 r. 4 0 -. ) MJ N ...TOPICAL HAZARD EVALUATION . , OF CANDIDATE INSECT REPELLENT AI3-35713-aGa N -PENTYLVALERAMIDE STUDY NO. 51-0802-77 AUGUST 1975 - AUGUST 1976 Approved...CLASSIFICATION DO’ THIS PAGE (Wlhet Der. Znftro* REPORT DOCUMENTATION PAGE EA~D N RM 1. REPORT NUMBER 2. GOVT ACCESSION No. 3. RECIPIENT’S CATALOG NUMBER 51

Geochemical Tools and Paleoclimate Clues: Multi-Molecular and Isotopic Investigations of Tropical Marine Sediments and Alpine Ice

DTIC Science & Technology

2006-02-01

Ecology 66, 1279- 1295 . Meyers, P.A., 1997. Organic geochemical proxies of paleoceanographic, paleolimnologic, and paleoclimatic processes. Organic...04JC 1) 268 C, 00 44.ý CJC W O r’JIY)rj , F- ’ L -- 1 0 ’CD N fi 4rn 4 w-u’-4ý -CD CD 03 I-I cr~c0 04 m ccm [ý r~ a) n ýn M!n C Un 00p nrj tr 0 CD N...Ctrtt M I Cl L 00 4) DAc LN ’ tr , T ~ oc 0 NT 7[Lftjf ’C4 30 $ N 0 0 ’a a a a a a N ,f a a a a W 0 7- (fl 0)0 W, NJ A ~ DU J A ’ 0 Z ; ,oF A; UNI - at

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, Fiscal Year 1987. Part 14. Okinawa Kankyo-Pultrusions Corporation.

DTIC Science & Technology

1987-01-01

1 00 aca Y. 0 139-4-4M ᝰ  ɘ-4-400-4-4-f 1(2 z 0 I= 09 Cie w I -IC Cn 10-4 w U 000 0 r, 0 0 1 4c cn 1 4c C-) cn ZLn com -4-0-0 0.00 CL in 0 0 (L...0 No N N) (O(ONNC ". N1 NL C -I 4 (nI Z- -’ A Mz - COm 0140 -4,- n( I o )MN&1 0 I n 00 04 - J " cc t 0140 1(4 14C .4’ NNN NN 80104000 0-4 N () 0 (0 V...j 0 0 .4 0 00 MO 3 0 <-Cc00m-cc-c <- x, ~4.-C < x-I-x-C < < 0 N 0N 3 0N ON 1- 0 304 Com 004 0.4 l’ 0 ) 0- t- - 0 0 1’ ) 1-o 0 0 0 3 30 *4U, 0 0 0) -4

Department of the Navy FY 1995 Budget Estimates. Justification of Estimates, Research, Development, Test and Evaluation, Navy Descriptive Summaries

DTIC Science & Technology

1994-02-01

t,- r- 0N o 1nCO10 in %D ’DatLin 0 H-0 -4 ’ 100 o o% it -4 NoI c4 01- o ja iv 0 -14 H 4 ý4 .-4 - 4.j .-- .-4 .I.4 -H - 0 . 4 ~0 4 z z4 Cn E4-4- Oz~0...N (N(40( 4MM MM MHO F4t4W > 1% (N4 r4 E’ M 4 z E-4 0 t 00000 00000w000000000z 0000 1010 010.0 m00011 u 0100to 0as, 0 . z0( N 100 w0C’ 000000000000000...H 0. 04 04 0 w- 100 4 -0 4 ac 0% n~U .- 40% i -4in a inN . I in00 -4- ~.-4N -4 ). 4-4-..4~4-0inini 4 n -1 -- 00 Oi n4 n~i 000000 O000000C6000000>040

Geographic List of Prime Contract Awards. Oct 91 - Sep 92. FY92. (Fort Hood Texas - Northfield Vermont)

DTIC Science & Technology

1993-01-01

00N00LALAm00)LA0 -- n, o-, nc4-- n( )m-zTI o-ir -- * 0)CIO 1C) -- i-s a) CI W N 1wo jini nI-I 0 o o01 o ,w 4-1t in WL L L L 0 00 0 0 A 0 01"C4 0 ’ ~ 0C14r...411 N ,N 1`4 NJ I Q -4-4 to >-.-- zzzzzzz z zz ZZ ZZ> >>--> - Uf C41I 0-40 11 au Mə <<- JINI 4- (04 4N014INN Uf 00(n o U n (inl ý4 - I4-4- 4 -4 i...N Is 1(000o atoz z z z z z z z zz z motto00 It 7) 00 0U)..VN(to-4 N l (a0 000 0 0 In01C* an 0 Ga I(00 Gao If 0)C0an.0(0 In O0NC 0 0 0 -*MM’ N o A IC

Italy’s All-Volunteer Army: An Analytical Framework for Understanding the Key Policy Issues and Choices During the Transition

DTIC Science & Technology

2002-01-01

0U) co 0 t - ; m. ci* 0) 00 .-- 0) :9 0f F,0 0 0) -N 0) ( D01 CJO 0~ (00)0 0 -T MCl*0 (0 0)9n 0) 0 M 0)0C)0 0 0) m 00 CO (0) cl (000 R0oo-l toc 0 0 00...1483-ARPA, 1974. Nones, Michele, L’efficienza del Sistema Difesa, Rome, Italy: Documenti IAI, 1996. O’Keefe, Mary, W. Kip Viscusi, and Richard J

Department of the Army Justification of Estimates for Fiscal Year 1987, Submitted to Congress February 1986. Operation and Maintenance, Army. Volume 1.

DTIC Science & Technology

1986-02-01

Izu ac)L 4)V C rio 2C E-4-4 in 0) M) V VOz V C 0 d 0C 0 C)4 0 C 4 tiC r. . a) ". HL 1- o 0) CC -4 A.) w 4 1-4 :5 c) r_ cC c Ř 0 0 w) W4 0 P-4 a) 0 S 0...CL.C 0.491 hi% % A ~ 9.~§~: ~:~-:*~~.*.-~*:*~~; o~-a’~--o~"T q - 0 t- O OC M -Z oo ’- -- iP - LL. 00 -)N - - CYu LLL; 00-0’JUL) . 0 C n% coO 0 TN N: O om...Crzjz 41 - . *1 4-a 4. -4 . A~’i m* * W0 : ) c a): (0 4.. S 4.10t - *1 5.n- *0 M* -4 0 cn 0 12 ’a .3 w8 -4 C14 0 w . 0 4-4 C ~ 0 * *~ 4J CZ4 ~ 5 D IP tv r

The Acute Effects of Single Exposures to White Phosphorus Smoke in Rats and Guinea Pigs

DTIC Science & Technology

1980-09-01

the smoke cloud.6 Although not observed in animal exposures, it has been reported that the smoke is irritating to the eyes and nose in moderate...rn o en 00) tN- 00 V) 0 (3, - 0 Zz V) M~ rnr 1 cvj 0 No q0 t NOr-0 00 M 00 0 - 00 Q,. 01 ( 06 06 00 6S 06 -- 11 0 6 vc-r- 0n 0o t-5 0 z r- n tn cc -n...concentra- tions was obtained. Rat exposure concentrations ranged from 505 to 2018 mg/cu m with concen- trations X time (Ct’s) from 30,300 to 181,620 mg min

Limestone Creek, Local Flood Protection, Fayetteville, New York

DTIC Science & Technology

1990-08-01

maple, slippery elm , syca- more, black locust, dogwood, sumac, choke cherry, creeping cucumber, goldenrod and teasel. Wooded areas on the surrounding...CIRCLE C. -AkA- BARKER t LANE IVIALL KEN 4A AVE 2 7rflEE EEOER r ’A CHANIC S ENWOOD LANE Shcoping cc a ttev Center RNE -V ELM STREET GENES STREET...0~i r; 0 i cyO n 0 00.- w ~ 0vwf N - N 9 00 0 , - 00 -l N NO w IV a,0 200 000 -0 a, r. elm ID MW PN0NIN MOJn 0m M e. 0’iamo 0 q0 ON T0 Fw% N..NV

An Analysis of Completion Times at Various Army Training Centers of Programmed Instruction Materials for MOS 71 B 10, MOS 71 H 20, & MOS 71 B 20/30.

DTIC Science & Technology

1972-06-01

I I I I oil N 4 N N~ N N0 Cot m CA r N -( qr% W % P- a %.P- ON -Y ON % enm w% -%0 DC 110 oV to 0% 0 0D 0 *n 0n e 00 O N Ln m~ CV) co ONN 11: v- 0...CC’D a) =) c’.C’ C) CC) CD C.)’ L t- I’D CM " C’.JCO.J U/ I U) I r- C40 U)zj )Dm t D C Dc ma m’ CD C) CD 10 co a II I ct C’ ’ ’ ’ 𔃾 (4 (. ’ ’ LUV ...been approv S i fOr Public release and slo; Its distribution is unlimited. 9

A new series of oxycarbonate superconductors (Cu{sub 0.5}C{sub 0.5}){sub m}Ba{sub m+1}Ca{sub n-1}Cu{sub n}O{sub 2}({sub m+n})+1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Takayama-Muromachi, E.; Kawashima, T.; Matsui, Y.

1994-12-31

We found a new series of oxycarbonate superconductors in the Ba-Ca-Cu-C-O system under high pressure of 5 GPa. Their ideal formula is (Cu{sub 0.5}C{sub 0.5}){sub m}Ba{sub m+1}Ca{sub n-1}Cu{sub n}O{sub 2}({sub m+n})+1 ((Cu,C)-m(m+1)(n-1)n). Thus far, n=3, 4 members of the m=1 series, (Cu,C)-1223 and (Cu,C)-1234, have been prepared in bulk while n=4, 5 members, (Cu,C)-2334 and (Cu,C)-2345, have been prepared for the m=2 series. (Cu,C)-1223 shows superconductivity below 67 K while T{sub c}`s of other compounds are above 110 K. In particular, (Cu,C)=1234 has the highest T{sub c} of 117 K.

Comparison of Explosives Residues from the Blow-in-Place Detonation of 155-mm High-Explosive Projectiles

DTIC Science & Technology

2006-06-01

were M107 high-explosive deep-cavity 155-mm howitzer projectiles with a supplemental charge and an M739 point- detonating fuze mounted in the nose...M107, HE, w/o fuze IOP03E100-011 14 1390010809447 N340 Fuze, point-detonating, M739 MA-84B007-013 14 1375014151232 ML47 Cap, blasting, non-electric 30... M739 N340 0 21 0 ə Cap, blasting, M11 ML47 ə 27 ə ə Cap, blasting, M13 MN03 0 ə 0 ə Cap, blasting, M14 MN06 0 0 0 ə Cord, detonating M456 0

All Prime Contract Awards by State or Country, Place and Contractor. Part 11. (Aitkin, Minnesota-Zephyr Cove, Nevada)

DTIC Science & Technology

1989-01-01

0 )N 41 nuuu~f~01Xflininu33x33:33330I- ( 5 0 CL L . CL.CL 0ilto1 0 N 11000000000000000000000011 2 0 ) 0 ) 0 ) 0 ) 0 ) 011Z2 I00N 11 z00 000000 0000...4 4 4 4 4 4 44 IIC1 ( 0 -NOI 5 )(~ )) C)’C1: 00c ’ I 0 00 000M 00 0 0 0 00 0 0 0 0 I.I < 0 -~l 0 - 00 00 00 0000000000000000000L.I.. WU-I A 40-eN Ii~ mj X00...I m N 1(A) 04 ɜ a I-I -. Z .8 - --. 1-1 - 1--.1-.1-

Cinnamon water extracts increase glucose uptake but inhibit adiponectin secretion in 3T3-L1 adipose cells.

PubMed

Roffey, Benjamin; Atwal, Avtar; Kubow, Stan

2006-08-01

The effects of three concentrations (0.2, 0.3, and 0.4 mg/mL) of a cinnamon extract (CE) (Cinnamomum zeylanicum) on glucose uptake and adiponectin secretion in 3T3-L1 adipocytes were examined in the presence and absence of 0.5 nM and 50 nM insulin. In the absence of insulin, adipocytes exposed to 0.2 mg/mL CE showed an approximate two-fold increase in glucose uptake relative to controls although glucose uptake was unaffected by the two higher concentrations of CE. No effect of CE on glucose uptake was noted in the presence of 0.5 nM insulin whereas the two highest concentrations (0.3 and 0.4 mg/mL) of CE showed a significant dose-dependent decrease in glucose uptake in the presence of 50 nM insulin. Treatment of the adipocytes with 50 nM wortmannin, an irreversible inhibitor of the p110 isoform of phosphoinositide 3'-kinase, was associated with complete inhibition of the stimulated glucose uptake induced by 0.2 mg/mL CE. Treatment of the adipocytes with 0.2 mg/mL CE was associated with an inhibition of adiponectin secretion to levels that were nondetectable. The present study indicates that although 0.2 mg/mL CE has insulin-mimetic action in 3T3-adipocytes in terms of glucose uptake, secretion of the antidiabetic hormone adiponectin is adversely affected.

DoD Prime Contractors Receiving Awards over $25,000. FY 1992 (102 Construction Inc -- ZZYZX)

DTIC Science & Technology

1993-01-01

0E n- r4 N-N 0Z4 22-.0 02Cx)𔃾 b w0 DI20 0 00 0 r-) ) z0 0ýýP Ni, 000u M Z W M -I ɜ~ .~ 02 x 0 200t 0 ~ ~ H 0 002U "Il. . z-t 0 -: zaw wý0z ’-4...0 0 0 Q tun - -14-1-14-1-14-1-14-1-14-"-14- 00 "Z Z - a 4-.0 0 : 44: Q< 0 00 0 g 4 - 0 0 0 U t-4 x O u : U ( 0 H H1 m x En 00 )0 z IHQ E 0 0 z 0 -En- u

In vitro activity of Ceftaroline against bacterial pathogens isolated from patients with skin and soft tissue and respiratory tract infections in African and Middle Eastern countries: AWARE global surveillance program 2012-2014.

PubMed

Karlowsky, James A; Biedenbach, Douglas J; Bouchillon, Samuel K; Hackel, Meredith; Iaconis, Joseph P; Sahm, Daniel F

2016-10-01

The objective of this report was to document antimicrobial susceptibility testing surveillance data for ceftaroline and comparative agents from the AWARE (Assessing Worldwide Antimicrobial Resistance Evaluation) global surveillance program for bacterial pathogens causing skin and soft tissue and respiratory tract infections in African and Middle Eastern countries from 2012 through 2014. Pathogen identities were confirmed by MALDI-TOF and antimicrobial susceptibility testing performed by CLSI broth microdilution methodology in a central laboratory. All methicillin-susceptible Staphylococcus aureus (MSSA) (n= 923; MIC90, 0.25 μg/mL) and 91.8% of methicillin-resistant S. aureus (MRSA) (n= 1161; MIC90, 1 μg/mL) tested were susceptible to ceftaroline. The maximum ceftaroline MIC observed for isolates of MRSA was 2 μg/mL. All Streptococcus pyogenes (n= 174; MIC90, 0.008 μg/mL), Streptococcus agalactiae (n= 44; MIC90, 0.015 μg/mL), Streptococcus pneumoniae (n= 351; MIC90, 0.25 μg/mL), and Haemophilus influenzae (n= 84; MIC90, ≤0.015 μg/mL) were susceptible to ceftaroline. Rates of susceptibility to ceftaroline among ESBL-negative Escherichia coli (n= 338), Klebsiella pneumoniae (n= 241), and Klebsiella oxytoca (n= 97) were 89.1% (MIC90, 1 μg/mL), 94.2% (MIC90, 0.5 μg/mL), and 99.0% (MIC90, 0.5 μg/mL), respectively. Copyright © 2016. Published by Elsevier Inc.

Infinitely many {N}=1 dualities from m + 1 - m = 1

NASA Astrophysics Data System (ADS)

Agarwal, Prarit; Intriligator, Kenneth; Song, Jaewon

2015-10-01

We discuss two infinite classes of 4d supersymmetric theories, T N ( m) and {U}_N^{(m)} , labelled by an arbitrary non-negative integer, m. The T N ( m) theory arises from the 6d, A N - 1 type N=(2,0) theory reduced on a 3-punctured sphere, with normal bundle given by line bundles of degree ( m + 1 , - m); the m = 0 case is the N=2 supersymmetric T N theory. The novelty is the negative-degree line bundle. The {U}_N^{(m)} theories likewise arise from the 6d N=(2,0) theory on a 4-punctured sphere, and can be regarded as gluing together two (partially Higgsed) T N ( m) theories. The T N ( m) and {U}_N^{(m)} theories can be represented, in various duality frames, as quiver gauge theories, built from T N components via gauging and nilpotent Higgsing. We analyze the RG flow of the {U}_N^{(m)} theories, and find that, for all integer m > 0, they end up at the same IR SCFT as SU( N) SQCD with 2 N flavors and quartic superpotential. The {U}_N^{(m)} theories can thus be regarded as an infinite set of UV completions, dual to SQCD with N f = 2 N c . The {U}_N^{(m)} duals have different duality frame quiver representations, with 2 m + 1 gauge nodes.

Infinitely many $$ \\mathcal{N}=1 $$ dualities from m + 1 - m = 1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Agarwal, Prarit; Intriligator, Kenneth; Song, Jaewon

2015-10-06

We discuss two infinite classes of 4d supersymmetric theories, T N (m) and Umore » $$(m)\\atop{N}$$, labelled by an arbitrary non-negative integer, m. The T N (m) theory arises from the 6d, A N-1 type N=(2,0) theory reduced on a 3-punctured sphere, with normal bundle given by line bundles of degree (m + 1, -m); the m = 0 case is the N=2 supersymmetric T N theory. The novelty is the negative-degree line bundle. The U$$(m)\\atop{N}$$ theories likewise arise from the 6d N=(2,0) theory on a 4-punctured sphere, and can be regarded as gluing together two (partially Higgsed) T N (m) theories. The T N (m) and U$$(m)\\atop{N}$$ theories can be represented, in various duality frames, as quiver gauge theories, built from T N components via gauging and nilpotent Higgsing. We analyze the RG flow of the U($$(m)\\atop{N}$$ theories, and find that, for all integer m > 0, they end up at the same IR SCFT as SU(N) SQCD with 2N flavors and quartic superpotential. The U$$(m)\\atop{N}$$ theories can thus be regarded as an infinite set of UV completions, dual to SQCD with N f = 2N c. The U$$(m)\\atop{N}$$ duals have different duality frame quiver representations, with 2m + 1 gauge nodes.« less

[Voice acoustic study of plasma radiofrequency ablation for the treatment of laryngeal premalignant lesions].

PubMed

Zang, Y Z; Wan, B L; Jia, X D; Wang, G K

2016-11-01

Objective: To study the voice function effect of low temperature plasma radiofrequency ablation in the treatment of patients with laryngeal premalignant lesions. Method: Fifty cases of laryngeal premalignant lesions were treated with low temperature plasma radiofrequency ablation. All of the patients were examined by electronic laryngoscopy and acoustic analysis(F0，Jitter，Shimmer，NNE，HNR) in 2 weeks,1 month,3 months after surgery. Voice acoustic results were compared with a control group of 50 normal adults for the further analysis. Result: Fifty patients with laryngeal premalignant lesions were treated by low temperature plasma radiofrequency ablation.The result showed that 47 patients(94%)were successfully decannulated without serious complications, such as dyspnea, aphonia and anterior glottic stenosis. Acoustic analysis showed that F0,Jitter,Shimmer and NNE were significantly different from normal 2 weeks after surgery（ P <0.01）.Voice function recovered weakly 1 month after operation（ P <0.05）.There were no significant differences in the vocal parameters between plasma radiofrequency ablation group and control group 3 months after surgery( P >0.05). Conclusion: Radiofrequency coblation was a safe,minimally invasive and effective surgical method and can be widely used to treat laryngeal premalignant lesions．. Copyright© by the Editorial Department of Journal of Clinical Otorhinolaryngology Head and Neck Surgery.

Variation of biomass and carbon pool with NDVI and altitude in sub-tropical forests of northwestern Himalaya.

PubMed

Bhardwaj, D R; Banday, Muneesa; Pala, Nazir A; Rajput, Bhalendra Singh

2016-11-01

In the present study, forests at three altitudes, viz., A 1 (600-900 m), A 2 (900-1200 m) and A 3 (1200-1500 m) above mean sea level having normalised differential vegetation index (NDVI) values of N 1 (0.0-0.1), N 2 (0.1-0.2), N 3 (0.2-0.3), N 4 (0.3-0.4) and N 5 (0.4-0.5) were selected for studying their relationship with the biomass and carbon pool in the state of Himachal Pradesh, India. The study reported maximum stem density of (928 trees ha -1 ) at the A 2 altitude and minimum in the A 3 and A 1 with 600 trees ha -1 each. The stem densities in relation to NDVIs were observed in the order N 5 > N 3 > N 4 > N 1 > N 2 and did not show any definite trend with increasing altitude. Highest stem volume (295.7 m 3  ha -1 ) was observed in N 1 NDVI and minimum (194.1 m 3  ha -1 ) in N 3 index. The trend observed for stem biomass at different altitudes was A 3 > A 1 > A 2 and for NDVIs, it was N 5 > N 1 > N 4 > N 2 > N 3 . Maximum aboveground biomass (265.83 t ha -1 ) was recorded in the 0.0-0.1 NDVI and minimum (169.05 t ha -1 ) in 0.2-0.3 NDVI index. Significantly, maximum total soil carbon density (90.82 t C ha -1 ) was observed in 0.4-0.5 NDVI followed by 0.3-0.4 NDVI (77.12 t C ha -1 ). The relationship between soil carbon and other studied parameters was derived through different functions simultaneously. Cubic function showed highest r 2 in most cases, followed by power, inverse and exponential function. The relationship with NDVI showed highest r 2 (0.62) through cubic functions. In relationship between ecosystem carbon with other parameters of different altitudinal gradient and NDVI, only one positively significant relation was formed with total density (0.579) through cubic function. The present study thus reveals that soil carbon density was directly related to altitude and NDVIs, but the vegetation carbon density did not bear any significant relation with altitude and NDVI.

Statistical Processing Methods for Polarimetric Imagery

DTIC Science & Technology

2008-09-01

c ) G.G. Stokes portrait normalized bounds 5 10 15 20 0 0.2 0.4 0.6 0.8 1 N or m al iz ed v ar ia nc e Number of frames average...Bar target Stokes bounds 0 10 20 30 40 50 60 10 −2 10 0 10 2 10 4 10 6 N or m al iz ed v ar ia nc e Channel spacing S 0 S 1 S 2 ( c ) PC board...0.6 0.7 iteration N M S E multichannel single channel ( c ) S2 Figure 4.7: NMSE quartiles for the Simulated Stokes

Research on Advanced Nondestructive Evaluation (NDE) Methods for Aerospace Structures

DTIC Science & Technology

2004-03-01

al iz ed re sp on se (l in ea r s ca le ) N or m al iz ed re sp on se (l in ea...variations showed some differences after weathering (Figure 4.2.2-2). 0.0 1.0 2.0 0 1 2 3 4 5 Weathering time (hours) N or m al iz ed p ea k ar ea 0.0...1.0 2.0 0 1 2 3 4 5 Weathering time (hours)N or m al iz ed p ea k he ig ht s (A) (B) 52 Prior to weathering, the height variation

General Aviation Activity and Avionics Survey 1985

DTIC Science & Technology

1987-03-01

M V 4c0 -- nC 0.. (D* - V - w * 0 i L)( IsO n cc0 5-0 la-N 0 N -O 0- M 05. 34’ N cc -- ND --0 C o hi oo8NI laW07- vr--- v -- C .0 .9. ooN -4 (.V9 I 𔃾...9v Iso go C. Go ill hiWIZ 0r o390 4cC 0In Inwl C4-0- . 0’ ow0- w ~ -- -04 0 c > In A.,. i wn cV - Is %0 00 v I O D4 0 N-c tf C4 4( O 00-a - C c-r w...3801554 SKRSKYS58 8141801 REIMS ISO 7530128 SCHL ERa 3801559 SKRSKYS58 8141804R[INS ISO 7530132 SCHLERK8 3801563 SKRSKYS58 8141806 RElms 150 7530134

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 13. (Michigan Power Company-Noord Natie S V)

DTIC Science & Technology

1989-01-01

M-4 it 0n no ( nCAo 0 na0 0 noootioInilI r r ALLIn (no0 in-4 (n-4 Oi1lV In M0-4 11O-4 00 00 0 00- 4- 4 4- 4-4-4 -4 -4- - 41-4 -4-444-4 00 00) 0-4 liW...4 -1( a -4 -.10 j 0 0 in 00-4 1100 00. "C)0 004 Q>44Q4000 LA4 44a 0 ON "N (. "U 4110100-4 x110.4 NCAO ) 0) a (1 000N )0 00..)x.a 0.. 0 x 0(0 0( 04X

Formation of the thioester, N,S-diacetylcysteine, from acetaldehyde and N,N'-diacetylcystine in aqueous solution with ultraviolet light

NASA Technical Reports Server (NTRS)

Weber, A. L.

1981-01-01

The thioester, N,S-diacetylcysteine, is formed during the illumination of phosphate buffered (pH 7.0) aqueous solutions of acetaldehyde and N,N'-diacetylcystine with ultraviolet light. The yield of N,S-diacetylcysteine relative to N-acetylcysteine and unidentified products progressively increases as ultraviolet light below 239 nm, 253 nm and 281 nm is cut off with optical filters. When ultraviolet light below 320 nm is removed with an optical filter, there is no detectable reaction. Illumination of 0.025 M N,N'-diacetylcystine with 0.5 M and 1.0 M acetaldehyde with filtered ultraviolet light gives, respectively, 20% and 80% yields of N,S-diacetylcysteine. In the reaction with 1.0 M acetaldehyde, N-acetylcysteine forms early in the reaction and later decreases with its conversion to N,S-diacetylcysteine. The prebiotic significance of these reactions is discussed.

Youth Attitude Tracking Study II Wave 16 -- Fall 1985. Supplementary Tabulations,

DTIC Science & Technology

1986-02-01

W ~0) _.j- to b CD in fa C v N S Sw w < I-. . .. < .J4- 00 CL C4 V N 5 I 0) .~ 4 0 0 0 o m) a N I ZWI 4-C P. . . m -.. -u 0 1- 0; 1.:5 5 5 I ɜ 0 . .4...i 0. cc4 I at > ~ aiI- U . 281 * I I W 2 00 CL 5 gL *~ ~ U) (l J ton an a S C I ’ I--. I- I.av -C 2 WI-. . - >a- I- mW w v 1 0 0 0 5 44 o z o I.- U

Dynamic Solidification in Nanoconfined Water Films

DTIC Science & Technology

2010-06-16

C . Ramanujan , H. O. Ozer, and A. Oral, Phys. Rev. B, 70, 054114 (2004). [6] T. D. Li, J. P. Gao...unclassified c . THIS PAGE unclassified Standard Form 298 (Rev. 8-98) Prescribed by ANSI Std Z39-18 Water is the fundamental solvent of all...Displacement (nm) 0.0 0.2 0.4 0.6 0.8 1.0 1.2 1.4 D a m p in g c o e ff ic ie n t (m N s /m ) 0.0 0.5 1.0 1.5 0 1 2 3 4 5 6 7 R e la x a ti o n t

In Vitro Susceptibility of Plasmodium vivax to Antimalarials in Colombia

PubMed Central

Fernández, Diana; Segura, César; Arboleda, Margarita; Garavito, Giovanny; Blair, Silvia

2014-01-01

The in vitro susceptibilities of 30 isolates of Plasmodium vivax to a number of antimalarials (chloroquine [CQ], mefloquine, amodiaquine, quinine, and artesunate [AS]) were evaluated. The isolates came from the region of Urabá in Colombia, in which malaria is endemic, and were evaluated by the schizont maturation test. The 50% inhibitory concentration (IC50) was 0.6 nM (95% confidence interval [CI], 0.3 to 1.0 nM) for artesunate, 8.5 nM (95% CI, 5.6 to 13.0 nM) for amodiaquine, 23.3 nM (95% CI, 12.4 to 44.1 nM) for chloroquine, 55.6 nM (95% CI, 36.8 to 84.1 nM) for mefloquine, and 115.3 nM (95% CI, 57.7 to 230.5 nM) for quinine. The isolates were classified according to whether the initial parasites were mature or immature trophozoites (Tfz). It was found that the IC50s for chloroquine and artesunate were significantly different in the two aforementioned groups (P < 0.001). The IC50s of CQ and AS were higher in the isolates from mature Tfz (CQ, 39.3 nM versus 17 nM; AS, 1.4 nM versus 0.3 nM), and 10% of the isolates showed lower susceptibilities to one of the antimalarial drugs, 13.3% to two antimalarial drugs, and 3.3% to more than three antimalarial drugs. It should be highlighted that despite the extensive use of chloroquine in Colombia, P. vivax continues to be susceptible to antimalarials. This is the first report, to our knowledge, showing in vitro susceptibilities of P. vivax isolates to antimalarials in Colombia. PMID:25114141

Myoglobin as a prognostic indicator for outcome in dogs with gastric dilatation-volvulus.

PubMed

Adamik, Katja N; Burgener, Iwan A; Kovacevic, Alan; Schulze, Sebastian P; Kohn, Barbara

2009-06-01

To determine whether myoglobin (Mb) is a useful prognostic indicator for outcome and to investigate any relationship between Mb and mortality in dogs with gastric dilatation-volvulus (GDV). Prospective study. Veterinary teaching hospital. Seventy-two dogs with GDV. Blood sampling. Mb levels were measured at the time of diagnosis (Mbt0), 24 hours (Mbt1), and 48 hours (Mbt2) after signs of GDV were recognized. Fifty-seven dogs survived (group I) and 15 dogs did not survive (group II). Mbt0 differed significantly between groups (P=0.04). Mbt0 in group I ranged from <30 to >700 ng/mL (n=57, median 74 ng/mL), and in group II from 34 to >700 ng/mL (n=15, median 238 ng/mL). Analysis of a receiver operating characteristic curve of Mbt0 suggested that the best single cutpoint would be 168 ng/mL (sensitivity 60.0%, specificity 84.2%). Fifty percent of dogs with Mbt0>168 ng/mL were euthanized, while 88.9% with Mbt0<168 ng/mL survived. Mbt1 and Mbt2 differed significantly between groups I and II. Mbt1 in group I ranged from 32 to >700 ng/mL (n=55, median 123 ng/mL), and Mbt1 in group II ranged from 131 to 643 ng/mL (n=7, median 343 ng/mL) (P=0.006). Mbt2 in group I ranged from 30 to 597 ng/mL (n=54, median 101 ng/mL), and in group II from 141 to >700 ng/mL (n=8, median 203 ng/mL) (P=0.02). In this study, Mbt0 is a moderately sensitive and specific prognostic indicator. Almost 90% of the dogs below the cutpoint survived to discharge, whereas 50% with Mbt0 above the cutpoint did not survive.

Optical and transport properties of LaTi{sub 1−x}M{sub x}(O,N){sub 3±δ} (x=0; 0.1, M=Nb{sup 5+}, W{sup 6+}) thin films prepared by plasma ammonolysis

DOE Office of Scientific and Technical Information (OSTI.GOV)

Maegli, Alexandra E.; Sagarna, Leyre; Populoh, Sascha

2014-03-15

Oxynitride thin films of composition LaTi{sub 1−x}M{sub x}(O,N){sub 3±δ} with x=0; 0.1 and M=Nb{sup 5+}, W{sup 6+} were prepared by nitridation via microwave-induced plasma (MIP) ammonolysis, which allowed keeping the nitridation time short (16 min). The higher possible oxidation states of the B-site substituents (Nb{sup 5+}, W{sup 6+}) with respect to Ti{sup 4+} caused higher N content for LaTi{sub 0.9}Nb{sub 0.1}(O,N){sub 3±δ} and LaTi{sub 0.9}W{sub 0.1}(O,N){sub 3±δ} compared to LaTiO{sub 2}N due to charge-compensation. XPS O 1s and N 1s core level and valence band spectra evidenced for increasing N content in the order LaTiO{sub 2}N

Airport Activity Statistics of Certificated Route Air Carriers

DTIC Science & Technology

1987-12-31

0 I - ; C o W’ ) 0 (N 1 0 1 04 CK0 I ! 1n 1 n wvco mL C o0 N 10 10 o-. ".C4C U,- Wi. W W W WWW W W WLi W W W WW W W W W4 WE>C . . .2IL .J .8L... fr 0; 0; 0 ow 0- <--. go w - w in ’A ID F (b 01 0 C’) m) 0DN I N 0 ’ 0D 8D mn 0D 0 0 N 0n I co Go VD V V1C) I D D 0 Cm 0 0f 0 01 N I 01 In in wD (D - 0...6 _- 5 6 3 z 5Z 6j -6 6 V) 0) 2.9 U) U) 14 (A*~ 09 (A~ 2)4 U ~ U ’n U A I ( 0 0 0 0 ) L A 0 0 0 0 In !;ZI W W WJW JW W wW w3 W WWW WJ I- W _c.j z 39

Two-Component Direct Fluorescent-Antibody Assay for Rapid Identification of Bacillus Anthracis

DTIC Science & Technology

2002-10-01

inhalational anthrax during the 2001 bioterrorism-associated anthrax out- break in the United States (6,17). Materials and Methods Bacterial Isolates B...n=6), pleural fluids (n=4), lung tissues (n=3), and lymph nodes (n=2), were collected from seven patients with laboratory-confirmed inhalational ...FITC) conjugates were lyophilized in HEPES buffer (0.05 M HEPES, pH 7.0, 0.10% glycine, 0.01 M d-sorbitol, 0.15 M KCl, and 5% d- trehalose ) containing

Carbon and Nitrogen Mineralization in Relation to Soil Particle-Size Fractions after 32 Years of Chemical and Manure Application in a Continuous Maize Cropping System.

PubMed

Cai, Andong; Xu, Hu; Shao, Xingfang; Zhu, Ping; Zhang, Wenju; Xu, Minggang; Murphy, Daniel V

2016-01-01

Long-term manure application is recognized as an efficient management practice to enhance soil organic carbon (SOC) accumulation and nitrogen (N) mineralization capacity. A field study was established in 1979 to understand the impact of long-term manure and/or chemical fertilizer application on soil fertility in a continuous maize cropping system. Soil samples were collected from field plots in 2012 from 9 fertilization treatments (M0CK, M0N, M0NPK, M30CK, M30N, M30NPK, M60CK, M60N, and M60NPK) where M0, M30, and M60 refer to manure applied at rates of 0, 30, and 60 t ha(-1) yr(-1), respectively; CK indicates no fertilizer; N and NPK refer to chemical fertilizer in the forms of either N or N plus phosphorus (P) and potassium (K). Soils were separated into three particle-size fractions (2000-250, 250-53, and <53 μm) by dry- and wet-sieving. A laboratory incubation study of these separated particle-size fractions was used to evaluate the effect of long-term manure, in combination with/without chemical fertilization application, on the accumulation and mineralization of SOC and total N in each fraction. Results showed that long-term manure application significantly increased SOC and total N content and enhanced C and N mineralization in the three particle-size fractions. The content of SOC and total N followed the order 2000-250 μm > 250-53 μm > 53 μm fraction, whereas the amount of C and N mineralization followed the reverse order. In the <53 μm fraction, the M60NPK treatment significantly increased the amount of C and N mineralized (7.0 and 10.1 times, respectively) compared to the M0CK treatment. Long-term manure application, especially when combined with chemical fertilizers, resulted in increased soil microbial biomass C and N, and a decreased microbial metabolic quotient. Consequently, long-term manure fertilization was beneficial to both soil C and N turnover and microbial activity, and had significant effect on the microbial metabolic quotient.

Prime Contract Awards Alphabetically by Contractor, State or Country, and Place. Part 2 (American Management Systems Inc, Arlington, Virginia - Basil & Trataros JV, Loring AFB, Maine), FY1991

DTIC Science & Technology

1991-01-01

m 00 -4w( I N0 >14 *C600 U a I4 co N0 p-~tq. 0MM)cx l o WO I -(( 1r (A U oo 2 6~ 000 UC x p 4N4 )-UL6000m U. 0 q c N10 00 fanC fal 06 000 U * q*I r...0) I -4"(. C. 00 0 0 0 0 0 0 0 00 0 0 0 0 Z00 0 0. U 0)-NO IIS WWOWaLJ WWWW WW OOOWWWOOOOW00000 D40 W >C 0 0 0a<>cU U I Mm -4N0 gen H -4 -4 4-4 -4 -4

Prime Contract Awards by State or Country, Place and Contractor. Part 16 (Fort Hill, Virginia - Chesapeake, Virginia), FY1991

DTIC Science & Technology

1991-01-01

0 *) 5 0 *. Ow- 010 1 03-40 l: L 2 S122...000O 1- 0 z 0 4f t M (04 i < I-- 4 1- 0 -4-41- 0 1) 1-4 L- CK isI 4a "O 141- f OL.A.. - U- mz I-- IfW 0 4 0N 44 I= 0 Ix I-- 4-4_-41 w I= IN 5 0 w-4 z...ifE’ N I o w 0 L) 0 L) 0 ) 0 )114m0 1-- 0 w 0 0 0 la4I0 4(N 1 1-- -41 - m)) 0 )1.- V# 5 -4 F- 0 # F- 0 #-4 0 11 I CON! If 24*

Icing Nozzle Element Optimization Test, January 1979

DTIC Science & Technology

1979-08-20

71 1 iit miir -. l 6-’ 1P.Ss L-0 1 .C1IC O (W.E xW N 0.I NA UO9 I O 0 S.. U VS..4*( SS~i4.4P4 66 hi (S ~ .4.4.4..4 (5 4J 6-(55 455 PC CI +Uli I-L I A...jIP In MCr (.’ tJ m w.. * WEL (*£7 £4lw Il 0 S .1 w. 0E 0 C00 0 0 CC 0 M7.M 4L ty4llm .0:0 0.-C U.~. f4 £ U(J M w -w w w .4 .0 e *w N cm *4** In C30...0,000). .- EL 71 [WW-PKL4W’Oj 3M] AO £101 a a 2. 4-- 1 L- - .4 f- . 74 V. - 3 0 W *~~~ 74- .C? U-. 4 ~ N. 5.0 ~ U 11 0 6+0 LLW. . . . . . . . .5-40

Missile Aerodynamics

DTIC Science & Technology

1988-01-01

considered preferable to inadequate treatment of more material. Readers frequently wonder what motivates the author in his arrange- ment of material. The...fins: M11, = Mn22 +~p’I (a2/sl)n/2]4"n - (2)21 in1, = 01*a rn13 = 0 ’n23 = 0 M33, =.533ps’ n =3 a =0 =n Ps4 n =4 a =0 7r . n=P8 n. fins H. Regular

Investigation of the Effect of Low Level Maritime Haze on DMSP VHR and LF Imagery.

DTIC Science & Technology

1980-09-09

LA S LO i-4 CNJ 0) r m~X LA3 crj (N > Co -i s- - -I CN r -~ 4J. 4-4 C) 4-) >1 Cl) 0H 9 -r-( Nl NV C 0 MN (1)0 r4 s-4 L 4-)4 Uv) Cu...be approximated as : 5-12 o 0 LA r40 oD (n rn N .4 .-4 0 C14.. LA Ln LA N- 0N 0C) LA 4 . l4-) r-. LA en C4 N . 049 0 1 E-4~ . (1 0 .t 0 ’p .r LA LA LA ...w CN C1 04 .00 C4.) r -4 O N~ ’. r - CA a ’.0 LA w m~ N1 Q4-1 Ř .4.4 Q) I- Q) in - r-4 O 4 1d𔃺 -4 0 0 4J *-0 0~

Electrical Resistivity of Ten Selected Binary Alloy Systems.

DTIC Science & Technology

1981-04-01

100 m 2 L q2 2 J 4m v 2 1 ......... 13 I Here e , m, and v are the electronic charge, mass, and velocity, q is the screening parameter, and I is the...potentiometer method E Eddy current decay method wpik* -7 25 P Van der Pauw method R Rotating magnetic field method V Voltmeter and ammeter direct...r:~ 0; tz 0 hi~~ 0*~ . 0 . 6 0 M 0 0 % -0 0 e o C M -" I- I n WT 8 L a .44 44 -44 4 %. -~~ 0 0 0 0 U0. ii S 4. 0c .2 s , Q t 04 INN ) nW V W 33

Evaluation of (99)  (m)TcN-MPO as a new myocardial perfusion imaging agent in normal dogs and in an acute myocardial infarction canine model: comparison with (99)  (m)Tc-sestamibi.

PubMed

Bu, Lihong; Li, Renfei; Jin, Zhongnan; Wen, Xiaofei; Liu, Shuang; Yang, Baofeng; Shen, Baozhong; Chen, Xiaoyuan

2011-02-01

(99)  (m)TcN-MPO ([(99)  (m)TcN(mpo)(PNP5)](+): mpo = 2-mercaptopyridine oxide and PNP5 = N-ethoxyethyl-N,N-bis[2-(bis(3-methoxypropyl)phosphino)ethyl]amine) is a cationic (99)  (m)Tc-nitrido complex, which has favorable biodistribution and myocardial uptake with rapid liver clearance in Sprague Dawley rats. The objective of this study was to compare the biodistribution and pharmacokinetics of (99)  (m)TcN-MPO and (99)  (m)Tc-Sestamibi in normal dogs, and to evaluate the potential of (99)  (m)TcN-MPO as a myocardial perfusion agent in canines with acute myocardial infarction. Five normal mongrel dogs were injected intravenously with (99)  (m)TcN-MPO. Venous blood samples were collected via a femoral vein catheter at 0.5, 1, 2, 3, 4, 5, 10, 20, 30, 40, 60, and 90 min post-injection (p.i.). Anterior-posterior planar images were acquired by γ-camera at 10, 20, 30, 60, 90, and 120 min p.i. Regions of interest (ROIs) were drawn around the heart, liver, and lungs. The heart/liver and heart/lung ratios were calculated by dividing the mean counts in heart ROI by the mean counts in the liver and lung ROI, respectively. For comparison, (99)  (m)Tc-sestamibi was also evaluated in the same five dogs. The interval period between the two examinations was 1 week to eliminate possible interference between these two radiotracers. In addition, single positron emission computed tomography (SPECT) images in the canine infarct model were collected 24 h after myocardial infarction at 30 and 60 min after the administration of (99)  (m)TcN-MPO (n = 4) or (99)  (m)Tc-Sestamibi (n = 4). It was found that (99)  (m)TcN-MPO and (99)  (m)Tc-Sestamibi displayed very similar blood clearance characteristics during the first 90 min p.i. Both (99)  (m)TcN-MPO and (99)  (m)Tc-Sestamibi had a rapid blood clearance with less than 50% of initial radioactivity remaining at 1 min and less than 5% at 30 min p.i. (99)  (m)TcN-MPO and (99)  (m)Tc-Sestamibi both showed good heart/lung contrast. The heart/liver ratio of (99)  (m)TcN-MPO increased with time (0.53 ± 0.06 at 10 min, 0.90 ± 0.062 at 30 min, and 1.22 ± 0.06 at 60 min p.i.), whereas the heart/liver ratio of (99)  (m)Tc-Sestamibi remained low at all time points (0.50 ± 0.03 at 10 min, 0.64 ± 0.03 at 30 min, and 0.60 ± 0.02 at 60 min p.i.). SPECT imaging studies in canines with acute myocardial infarction indicated that good visualization of the left ventricular wall and perfusion defects could be achieved at 30 min after administration of (99)  (m)TcN-MPO but not after (99)  (m)Tc-Sestamibi. The combination of reasonable heart uptake with rapid hepatobiliary excretion makes (99)  (m)TcN-MPO a promising new radiotracer for myocardial perfusion imaging.

All Prime Contract Awards by State or Country, Place and Contractor. Part 8. (Anderson, Indiana-Westwego, Louisiana)

DTIC Science & Technology

1989-01-01

I000 11 -4-4.-4 -4 -14 -4 01 -I (0 .4 N N1 1- I(MOO II r- CO (00 0 9 110(0 Coc N- co-) I MM 0ooo w If 1. 103M It U/) II0 CD (0r-. 4) -01 4-4-- 4-4...0((0 I C.-4-4 c 1-4 - - c -4 C -4 -4-I-4.-1-4 .-- 4 -4I C-4 c-4-4-4-4 r--4 -4 Io I M 0U I" (00( 14 ONNc"NN O N ONNNNNNN O i rh "N N NN ON N - 1(0(0 l

Divalent ion block of inward rectifier current in human capillary endothelial cells and effects on resting membrane potential

PubMed Central

Jow, Flora; Numann, Randy

1998-01-01

Cultured human capillary endothelial cells (HCEC) contain a large inward rectifier current, IK(IR), that can be abolished by removing external K+ or by adding 50 μm Ba2+.We show that IK(IR) is responsible for maintaining the hyperpolarized potential (−60.6 ± 0.5 mV, n = 83) of HCEC. Blocking IK(IR) with 50 μm Ba2+ shifts the zero current level and depolarizes HCEC by 36.5 ± 1.3 mV (n = 4).Increasing external Ca2+ concentration ([Ca2+]o) from 0.5 to 7 mm reduces the magnitude of IK(IR) by 36.5 ± 2.3 % (n = 5) and depolarizes the cells by 10.33 ± 2.4 mV (n = 3), whereas decreasing [Ca2+]o from 1.8 to 0.5 mm increases the amplitude of IK(IR) by 6.9 ± 1.9 % (n = 4). The relationship between [Ca2+]o and the percentage block of IK(IR) gives a Kd value of 5.4 ± 0.6 mm at −120 mV.IK(IR) is also blocked by other divalent ions, with Ba2+ >> Sr2+ > Mg2+ > Mn2+= Ca2+, and the block of peak current at −120 mV being 85.3 ± 3.2 % (n = 5) for 50 μm Ba2+, 62.9 ± 2.2 % (n = 5) for 5 mm Sr2+, 40.7 ± 2.5 % (n = 9) for 5 mm Mg2+, 33.4 ± 2.1 % (n = 5) for 5 mm Mn2+ and 32.9 ± 2.1 % (n = 5) for 5 mm Ca2+.The voltage dependence of Sr2+ block of peak IK(IR) occurred with a Kd value of 1.0 ± 0.09 mm for −140 mV, 1.9 ± 0.16 mm for −130 mV, 3.1 ± 0.28 mm for −120 mV, 4.6 ± 0.34 mm for −110 mV and 6.4 ± 0.5 mm for −100 mV (n = 5), with a calculated electrical distance (δ) of 0.44 from the outside. PMID:9729622

DoD Manual for Standard Data Elements

DTIC Science & Technology

1989-07-01

U4W333Iininin0.0. -)-6-6)---6- Z.............Law0C 44-Lawu Inn44....Jým --- ...- ..... -LaWzaýa ZaW aW>u 0 wwJ 22-. - Lawammi nmm4mm m mm awmwwww w2Z...a a 0 ON wzwzn i 0... ta L--za tun w awawww 4 0 UL OOOOO&WO ~ a. 0- C9 w~a 44U - . = X Z~(n~nZZ4 4 0 44 uJ0 - 0.4- 4-4 &. L 0 Z0000U W b, ta atS w xu...Z -a CW 1 04 Il-w lWa-I- - * U.zU 4 000 2 4N00 ZaW --0-aU.Ji.0 4c 0 W W M- o-t M ma- 0a-s--~0U- ZIW 2 j P- 0W I-a >1(AO i 4 U00.4K 11a-I--I-- j~ at

Pure Rotational CARS Thermometry Studies of Low Temperature Oxidation Kinetics in Air and Ethene-Air Nanosecond Pulse Discharge Plasmas

DTIC Science & Technology

2010-01-01

12600 12800 13000 13200 N or m al iz ed In te ns ity 0.0 0.2 0.4 0.6 0.8 1.0 1.2 Beam Contribution Raman Shift...wavenumbers) 0 200 400 600 800 0.0 0.2 0.4 0.6 0.8 1.0 1.2 Single Shot Wavenumbers 12200 12400 12600 12800 13000 N or m al iz ed In te ns ity 0.0 0.2 0.4...0.6 0.8 1.0 1.2 10 Shot Average Wavenumbers 12600 12800 13000 13200 N or m al iz ed In te ns ity 0.0 0.2 0.4 0.6 0.8 1.0 1.2 28 1.0E-7 1.0E-6

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tan Lin; Liu Fuyi; Armentrout, P.B.

The kinetic energy dependences of the reactions of Fe{sub n}{sup +} (n=1-19) with N{sub 2} are studied in a guided ion beam tandem mass spectrometer over the energy range of 0-15 eV. In addition to collision-induced dissociation forming Fe{sub m}{sup +} ions, which dominate the product spectra, a variety of Fe{sub m}N{sub 2}{sup +} and Fe{sub m}N{sup +} product ions, where m{<=}n, is observed. All processes are observed to exhibit thresholds. Fe{sub m}{sup +}-N and Fe{sub m}{sup +}-2N bond energies as a function of cluster size are derived from the threshold analysis of the kinetic energy dependences of the endothermicmore » reactions. The trends in this thermochemistry are compared to the isoelectronic D{sub 0}(Fe{sub n}{sup +}-CH), and to bulk phase values. A fairly uniform barrier of 0.48{+-}0.03 eV at 0 K is observed for formation of the Fe{sub n}N{sub 2}{sup +} product ions (n=12, 15-19) and can be related to the rate-limiting step in the Haber process for catalytic ammonia production.« less

Radiomics analysis of DWI data to identify the rectal cancer patients qualified for local excision after neoadjuvant chemoradiotherapy

NASA Astrophysics Data System (ADS)

Tang, Zhenchao; Liu, Zhenyu; Zhang, Xiaoyan; Shi, Yanjie; Wang, Shou; Fang, Mengjie; Sun, Yingshi; Dong, Enqing; Tian, Jie

2018-02-01

The Locally advanced rectal cancer (LARC) patients were routinely treated with neoadjuvant chemoradiotherapy (CRT) firstly and received total excision afterwards. While, the LARC patients might relieve to T1N0M0/T0N0M0 stage after the CRT, which would enable the patients be qualified for local excision. However, accurate pathological TNM stage could only be obtained by the pathological examination after surgery. We aimed to conduct a Radiomics analysis of Diffusion weighted Imaging (DWI) data to identify the patients in T1N0M0/T0N0M0 stages before surgery, in hope of providing clinical surgery decision support. 223 routinely treated LARC patients in Beijing Cancer Hospital were enrolled in current study. DWI data and clinical characteristics were collected after CRT. According to the pathological TNM stage, the patients of T1N0M0 and T0N0M0 stages were labelled as 1 and the other patients were labelled as 0. The first 123 patients in chronological order were used as training set, and the rest patients as validation set. 563 image features extracted from the DWI data and clinical characteristics were used as features. Two-sample T test was conducted to pre-select the top 50% discriminating features. Least absolute shrinkage and selection operator (Lasso)-Logistic regression model was conducted to further select features and construct the classification model. Based on the 14 selected image features, the area under the Receiver Operating Characteristic (ROC) curve (AUC) of 0.8781, classification Accuracy (ACC) of 0.8432 were achieved in the training set. In the validation set, AUC of 0.8707, ACC (ACC) of 0.84 were observed.

Geographic List of Prime Contract Awards. Oct 1992-Sep 1993. FY 1993. (Akron, New York-Williston, North Dakota). Part 9

DTIC Science & Technology

1994-03-01

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Equivalence of Computer and Paper-and-Pencil Armed Services Vocational Aptitude Battery Tests

DTIC Science & Technology

1986-08-01

1. WhNRODUCTION As the United States Armed Services move toward the iEplemntation of computer adaptive testing ( CAT ) with the Armed Services...0a -a 0 0 m 0% 0 " 0 0 0l 0 .0 N Řt %f V a0 . O%D"M o 4 c a % Pd 0% m o a 04 C co-4- O % aC C % nC -e C) 1001 0 0 0 0 00 01 1010100 0 *,00 0 ,0 0 C4...0% 00 0 0o 0 %D 0 0n 0" 0 C 0 40 t 0 0 Go C0*000100 1000000 000110 000 V4 a cc 0 0 0 00 0 0 0 0 0 04 0 0 0. fn 0 0 C" aC 4 %a V@4’-4 i00 ~ P4 WN a P

Geographic List of Prime Contract Awards. Oct 91 - Sep 92. FY92. (San Juan California - Yale New Haven Conn)

DTIC Science & Technology

1993-01-01

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Revised Uniform Summary of Surface Weather Observations for Maxwell AFB, AL, MSC 722265

DTIC Science & Technology

1985-12-01

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Antibacterial and synergistic effects of the n-BuOH fraction of Sophora flavescens root against oral bacteria.

PubMed

Lee, Kyung-Yeol; Cha, Su-Mi; Choi, Sung-Mi; Cha, Jeong-Dan

2017-01-01

The antibacterial activity of an extract and several fractions of Sophora flavescens (S. flavescens) root alone and in combination with antibiotics against oral bacteria was investigated by checkerboard assay and time-kill assay. The minimum inhibitory concentration/minimum bactericidal concentration (MIC/MBC) values for all examined bacteria were 0.313-2.5/0.625-2.5 μg/mL for the n-BuOH fraction, 0.625-5/1.25-10 μg/mL for the EtOAc fraction, 0.25-8/0.25-16 μg/mL for ampicillin, 0.5-256/1-512 μg/mL for gentamicin, 0.008-32/0.016-64 μg/mL for erythromycin, and 0.25-64/0.5-128 μg/mL for vancomycin. The n-butanol (n-BuOH) and ethyl acetate (EtOAc) fractions exhibited stronger antibacterial activity against oral bacteria than other fractions and extracts. The MICs and MBCs were reduced to between one half and one quarter when the n-BuOH and EtOAc fractions were combined with antibiotics. After 24 h of incubation, combination of 1/2 MIC of the n-BuOH fraction with antibiotics increased the degree of bactericidal activity. The present results suggest that n-BuOH and EtOAc extracts of S. flavescens root might be applicable as new natural antimicrobial agents against oral pathogens.

Dollar Summary of Federal Supply Classification and Service Category by Company. Part 5 (1005-4810)

DTIC Science & Technology

1991-01-01

L - U . > . > - > L U - > -L - <~~~~ a a L<>>> ><x< <xX< CL~~~~ a . a 0 <<< < 0 w0 0 w = Oi ( >4 -4 .1- zaw 4) - 4 0 0 .4 c0 0a Uo aa-a 4 w cc aw Co a...2)-) 1- m 0 tun t" 0 . w - 0 LU 14 r L U ) 0 D ) 1~ 0. )- 4 -14 Z 14 4 > 0 a o4 5l -c w4 w4 w ~ 00) m) -4 0 C, on N 0 O N40 0 N Nl co " -4 4 m~ sLn 00...II 0 I 4W 4W W -.4 -.4 0 .4 L 4 0 1- I ) -4- C)I I a - W go~~ I W >- ᝾ _j 1: tun I ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ ~ 4 I -)r c0 - 0 - (0 D ONt -4 0 m) 0 0 C0

A Randomized Multicenter Clinical Trial of Ultrathin Descemet Stripping Automated Endothelial Keratoplasty (DSAEK) versus DSAEK.

PubMed

Dickman, Mor M; Kruit, Pieter J; Remeijer, Lies; van Rooij, Jeroen; Van der Lelij, Allegonda; Wijdh, Robert H J; van den Biggelaar, Frank J H M; Berendschot, Tos T J M; Nuijts, Rudy M M A

2016-11-01

To compare visual acuity, refraction, endothelial cell density (ECD), and complications after Descemet stripping automated endothelial keratoplasty (DSAEK) and ultrathin DSAEK (UT-DSAEK). A multicenter, prospective, double-masked, randomized, controlled clinical trial. From 66 patients with irreversible corneal endothelial dysfunction dues to Fuchs' dystrophy who enrolled from 4 tertiary medical centers in the Netherlands, 66 eyes were studied. Participants were centrally randomized to undergo either UT-DSAEK or DSAEK, based on preoperative best spectacle-corrected visual acuity (BSCVA), recipient central corneal thickness, patient age, and recruitment center. Donor corneas were precut by a single cornea bank. Participants underwent ophthalmic examinations preoperatively and 3, 6, and 12 months after the operation, including manifest refraction, BSCVA using an Early Treatment Diabetic Retinopathy Study chart, and endothelium imaging. BSCVA 12 months postoperatively. Preoperative BSCVA did not differ between patients undergoing DSAEK (0.35 logarithm of the minimum angle of resolution [logMAR] [95% confidence interval {CI} 0.27-0.43]; n = 32) and UT-DSAEK (0.37 logMAR [95% CI 0.31-0.43]; n = 34; P = 0.8). BSCVA was significantly better after UT-DSAEK compared with that after DSAEK at 3 months (0.17 logMAR [95% CI 0.13-0.21], n = 31 vs. 0.28 logMAR [95% CI 0.23-0.33], n = 31; P = 0.001), 6 months (0.14 logMAR [95% CI 0.10-0.18], n = 30 vs. 0.24 logMAR [95% CI 0.20-0.28], n = 30; P = 0.002), and 12 months (0.13 logMAR [95% CI 0.09-0.17], n = 33 vs. 0.20 logMAR [95% CI 0.15-0.25], n = 29; P = 0.03). Refraction, ECD loss (40% at 3 months; P < 0.001), donor loss (DSAEK n = 2 vs. UT-DSAEK n = 3 [relative risk {RR} 1.4 {95% CI 0.24-7.5}; P = 0.7]), and graft dislocation (DSAEK n = 5 vs. UT-DSAEK n = 5 [RR 1.0 {95% CI 0.34-3.33}; P = 0.9]) did not differ between UT-DSAEK and DSAEK. Donor thickness was significantly thinner for UT-DSAEK (101 μm [95% CI 93-110 μm]; range 50-145 μm) than for DSAEK (209 μm [95% CI 196-222 μm]; range 147-289 μm; P < 0.001). This study indicates that compared with DSAEK, UT-DSAEK results in faster and better recovery of BSCVA with similar refractive outcomes, endothelial cell loss, and incidence of complications. Copyright © 2016 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved.

All Prime Contract Awards by State or Country, Place, and Contractor, FY 88. Part 9. (Athens, Maine-Woodbine, Maryland).

DTIC Science & Technology

1988-01-01

Mon MOlA mIooo (00 (000000 (0 00 (0 (000 (0000000000 IW001(mo(0 W00000000 (00 WO000 mo00 mo00 000000000 I(00LA41 0 0000000 0 000 00 00 000000000(fl(0LA4...tv. - 4- 4 4q r.4q 444l 4q. vC .Ct .44v 4444-4av T-a8 MOLA (0 I -(1N4NN l -N j -NN 4N 04 NNNNNN 0 "CVNN NN N N NNN NN4N0 4CJC- ~ l V"N N "N N I(Oin< wL...4 0"t -0 󈧈 44444 -04 V0 𔃾 V V 0I (00InCO i cNNNNN"~ CN EN EN C4NNNN cN .N .N .ENl 1 l cc c cC c0 0 1 (00In< i V00000 -4 0 to Ln MOLA M ’Wn Ln on n

Characteristics of luminal bicarbonate secretion by rat cecum in vitro.

PubMed

Canfield, P

1991-03-01

Under in vitro conditions the rat cecum transported HCO3- from the serosal to an unbuffered solution in contact with the mucosal side [Js----m = 7.12 +/- 0.18 mumol.cm-2.h-1 (n = 149)]. With reversed tissues, a significantly lower flux was obtained [Jm----s = 2.47 +/- 0.11 mumol.cm-2.h-1 (n = 42)]. Both fluxes were stable for several hours. Increasing the H+ gradient across the tissue for 60 min did not change either flux. Anoxia for 45 min reversibly reduced Js----m by 65 +/- 3% (n = 20) but had no effect on Jm----s. Both fluxes were linearly related to HCO3- concentration on the buffered side, but the slope for Js----m was 3.5 times that for Jm----s. When tissues were initially set up in HEPES buffer rather than HCO3-, Js----m was 0.12 +/- 0.05 mumol.cm-2.h-1 (n = 6), which is not significantly different from zero. Replacement of Na+ by choline reduced Js----m by 40 +/- 3% (n = 11) and ouabain (1 mM) by 24 +/- 3% (n = 5). Replacement of Cl- with isethionate or K+ with Na+ for 60 min did not alter Js----m. Serosal application of DIDS (0.5 mM) reduced Js----m by 24 +/- 6% (n = 6), but SITS (0.5 mM), furosemide (1 mM), acetazolamide (0.1 mM), amiloride (1 mM), and a proton pump inhibitor (Sch 28080, 50 microM) had no effect. Mucosal application of DIDS, furosemide, and amiloride had no effect on Js----m. Serosal tetrodotoxin (1 microM) and indomethacin (28 microM) were also without effect.(ABSTRACT TRUNCATED AT 250 WORDS)

Summary of Meteorological Observations, Surface (SMOS), Brunswick, Maine

DTIC Science & Technology

1988-12-01

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Geographic List of Prime Contract Awards. Oct 1992-Sep 1993. FY 1993. (Alpine, Utah-Pulaski, Virginia). Part 12

DTIC Science & Technology

1994-03-01

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All Prime Contract Awards by State or Country, Place, and Contractor. Part 16 (Albany Oregon-Newport Rhode Isld)

DTIC Science & Technology

1990-01-01

0 00 0- 0 -I -I- =0. ZZ1.-M a Inl c) N4 cr-. N ffm -40(a co -40 -4 N4 m0of wwiJ- a o 0 -.4 04000.0 0o -40 Co 0-4 C0 0 Ina W’-4 z 2 2 Z zz z2Z 2 22 z...0 u0 u00 4UU( CAI (A)0 W U n CA I ACCA (AU) C U I(044<I 00 -)4~’ 0 *VM C (0 C) (Y) (D q*CO(00 00-4 t U O(-4N4 MI 0-4 C S NNNNNc C’) 0 (D( to D (0c(0

The phase transition of matrix recovery from Gaussian measurements matches the minimax MSE of matrix denoising.

PubMed

Donoho, David L; Gavish, Matan; Montanari, Andrea

2013-05-21

Let X(0) be an unknown M by N matrix. In matrix recovery, one takes n < MN linear measurements y(1),…,y(n) of X(0), where y(i) = Tr(A(T)iX(0)) and each A(i) is an M by N matrix. A popular approach for matrix recovery is nuclear norm minimization (NNM): solving the convex optimization problem min ||X||*subject to y(i) =Tr(A(T)(i)X) for all 1 ≤ i ≤ n, where || · ||* denotes the nuclear norm, namely, the sum of singular values. Empirical work reveals a phase transition curve, stated in terms of the undersampling fraction δ(n,M,N) = n/(MN), rank fraction ρ=rank(X0)/min {M,N}, and aspect ratio β=M/N. Specifically when the measurement matrices Ai have independent standard Gaussian random entries, a curve δ*(ρ) = δ*(ρ;β) exists such that, if δ > δ*(ρ), NNM typically succeeds for large M,N, whereas if δ < δ*(ρ), it typically fails. An apparently quite different problem is matrix denoising in Gaussian noise, in which an unknown M by N matrix X(0) is to be estimated based on direct noisy measurements Y =X(0) + Z, where the matrix Z has independent and identically distributed Gaussian entries. A popular matrix denoising scheme solves the unconstrained optimization problem min|| Y-X||(2)(F)/2+λ||X||*. When optimally tuned, this scheme achieves the asymptotic minimax mean-squared error M(ρ;β) = lim(M,N → ∞)inf(λ)sup(rank(X) ≤ ρ · M)MSE(X,X(λ)), where M/N → . We report extensive experiments showing that the phase transition δ*(ρ) in the first problem, matrix recovery from Gaussian measurements, coincides with the minimax risk curve M(ρ)=M(ρ;β) in the second problem, matrix denoising in Gaussian noise: δ*(ρ)=M(ρ), for any rank fraction 0 < ρ < 1 (at each common aspect ratio β). Our experiments considered matrices belonging to two constraint classes: real M by N matrices, of various ranks and aspect ratios, and real symmetric positive-semidefinite N by N matrices, of various ranks.

Cellular reflectarray antenna and method of making same

NASA Technical Reports Server (NTRS)

Romanofsky, Robert R (Inventor)

2011-01-01

A method of manufacturing a cellular reflectarray antenna arranged in an m by n matrix of radiating elements for communication with a satellite includes steps of determining a delay .phi.m,n for each of said m by n matrix of elements of said cellular reflectarray antenna using sub-steps of: determining the longitude and latitude of operation, determining elevation and azimuth angles of the reflectarray with respect to the satellite and converting theta.sub.0 (.theta..sub.0) and phi.sub.0 (.phi..sub.0), determining .DELTA..beta..sub.m,n, the pointing vector correction, for a given inter-element spacing and wavelength, determining .DELTA..phi..sub.m,n, the spherical wave front correction factor, for a given radius from the central element and/or from measured data from the feed horn; and, determining a delay .phi.m,n for each of said m by n matrix of elements as a function of .DELTA..beta..sub.m,n and .DELTA..phi..sub.m,n.

Cellular reflectarray antenna and method of making same

NASA Technical Reports Server (NTRS)

Romanofsky, Robert R (Inventor)

2010-01-01

A method of manufacturing a cellular reflectarray antenna arranged in an m by n matrix of radiating elements for communication with a satellite includes steps of determining a delay .phi.m,n for each of said m by n matrix of elements of said cellular reflectarray antenna using sub-steps of: determining the longitude and latitude of operation, determining elevation and azimuth angles of the reflectarray with respect to the satellite and converting theta.sub.0 (.theta..sub.0) and phi.sub.0 (.phi..sub.0), determining .DELTA..beta..sub.m,n, the pointing vector correction, for a given inter-element spacing and wavelength, determining .DELTA..phi..sub.m,n, the spherical wave front correction factor, for a given radius from the central element and/or from measured data from the feed horn; and, determining a delay .phi.m,n for each of said m by n matrix of elements as a function of .DELTA..beta..sub.m,n and .DELTA..phi..sub.m,n..

Office-based Autologous Fat Injection Laryngoplasty for Vocal Process Granuloma.

PubMed

Hu, Hao-Chun; Hung, Yi-Ting; Lin, Shu-Yi; Chang, Shyue-Yih

2016-11-01

To present the outcomes of office-based autologous fat injection laryngoplasty for the treatment of vocal process granuloma in conjunction with glottic insufficiency. Retrospective chart review. This study included nine patients with vocal process granuloma in conjunction with glottic insufficiency who received autologous fat injection laryngoplasty. Videolaryngostroboscopic data, objective voice assessment, perceptual measurements of vocal quality, and subjective ratings of voice quality were examined before and after treatment. Of the nine patients, seven (78%) exhibited complete remission. The other two patients (22%) exhibited a partial response following the injection. In a subgroup of five patients who were refractory to antireflux and voice therapies, the resolution rate was 60%. Phonatory function presented significant improvements in jitter, noise-to-harmonic ratio, maximal phonation time, and asthenia. Videolaryngostroboscopic rating revealed significant improvements in closure phase ratio in the vibratory cycle. Autologous fat injection laryngoplasty can ameliorate glottic insufficiency and the resulting hyperfunctional behavior of the larynx. This therapy also encourages remission of vocal process granuloma and may represent an alternative treatment strategy. Copyright © 2016 The Voice Foundation. Published by Elsevier Inc. All rights reserved.

Expression and mutational analysis of Cip/Kip family in early glottic cancer.

PubMed

Kim, D-K; Lee, J H; Lee, O J; Park, C H

2015-02-01

Genetic alteration of cyclin-dependent kinase inhibitors has been associated with carcinogenesis mechanisms in various organs. This study aimed to evaluate the expression and mutational analysis of Cip/Kip family cyclin-dependent kinase inhibitors (p21CIP1/WAF1, p27KIP1 and p57KIP2) in early glottic cancer. Expressions of Cip/Kip family and p53 were determined by quantitative reverse transcription polymerase chain reaction and densitometry. For the analysis of p21 inactivation, sequence alteration was assessed using single-strand conformational polymorphism polymerase chain reaction. Additionally, the inactivation mechanism of p27 and p57 were investigated using DNA methylation analysis. Reduced expression of p27 and p57 were detected in all samples, whereas the expression of p21 was incompletely down-regulated in 6 of 11 samples. Additionally, single-strand conformational polymorphism polymerase chain reaction analysis showed the p53 mutation at exon 6. Methylation of p27 and p57 was detected by DNA methylation assay. Our results suggest that the Cip/Kip family may have a role as a molecular mechanism of carcinogenesis in early glottic cancer.

Alpha List of Prime Contract Awards. Oct 92-Sep 93. FY93. (Bt North America Inc. - Classified Location Domestic)

DTIC Science & Technology

1994-03-01

V4,(41, Or,.in cri nN c >1r- 0 10 f tao oinon0 40 M-4 -4 td n -w toce, of IC 𔃺 0 ca I1-&n UO0 - qtY(DC -04N I- . 30 C S-i Ur’L) . L-M4 U -4~ C...d 0o II Nca( 0 CI400W000 CD 10) Ny It 4. ev MNN.P.P rn If CIL I co00t I’l -4 co0 00000 -00 0 00C) 0 CV 4.4 Me V DCo tD H11 10 004D11 Nm Oin 000000...CO -4 0 11 -2c z .- Z 11 1 CO 0 fm 11 C z 2c z ed C z zx If I ca a 00 11 1- ed tv (d I td III 11 1 00000 11 00-t .- !`ý- W M It r- Ln Ln 0 tma N -4 -4

Mammalian Toxicological Evaluation of DIMP and DCPD. Phase 2

DTIC Science & Technology

1980-03-01

0r Daa r DaC ) -Cý C D C) 0 C) (n 0 0) %.C u 0 U Q CL Waa I- 41-1 .. ) D C 0 CU-ICj CD c ) &W 0" U ) C3 00 (.) 0 :I.- IU)L ODW w CZ -.jL r.c CD0 CO...AU 06. HO - 7-. -En -7ZL. .ZO.50 0 0 C% r- C00 M. H H a rNH CD ) (D r- Cjc 03 C H H CJ cqH *H tNNNN’ 1. 1 . 00O-1 N;6c*rý - +1 0-0 rt%% al c0C +1 +1+1...Zu w U) 0. Nr tvmvW4 tO r D- , C U-U U- 0nmC ’m A I0* i -6. I- -O! CJC - 0 U V0 cuD 0 S ul. m >0. mD 0.0 IC-D, ~ ...I 0.o ,r . lr TO-W-f. f 0ro coN *o

The Orbit of 1972-05B in its Final Phase, with Geophysical Inferences.

DTIC Science & Technology

1980-09-01

0- C4 -0- -0- I- -0-t " r,- N , c o C, 0 ’ C Z .2 to U- 0 - (ar 0-- -G- ( La - c/ m in o a in in in . I" m m as m, a; .0 w D Go4D 0 Fig 2 6660 6640 a...decrease in-orbital inclination a1A..40- .�. Iv/"IY- t" east sal Wind 2020./a, at & MaM height of Sb~i 14# ., was 01-M2 he soja activity vat high-, and thelttd o eMl from I to 64S~ N -W I

Electronic Principles Inventory, Keesler Technical Training Center

DTIC Science & Technology

1990-03-01

60 WC IC.U 06 VL a a OLIL 044 . 4 04V..a .6 IL I ;- acCa LL CL L L0.40 Z .44. 𔃾 C4’. v.W4 W L LL LC .0𔃾 %. a- L4. L .4 -4 L Lc. L 06 %. w 4. aC I...0014L 0 0 0 -.4 0 0 0. 4 4,0 21 0) .4 4, 0 00 0) .m 4 0 w4 00) L. a 0 0 6 00 (4 m 0 CI C c 0 0) f6 0 > Nj -4 ’A .4 WA 4,4,1 4,.L -W IA 4,4 -W 44 - .4...4 1-4 m r4 CY r4 4 :3 x 10 -C Co 10 Ln wl a 10 LA wl N %T N f, %T Ul in (y 4 4 (Y CD N to 0, 0, in La 0 ’r ?% 0, do do F6 0, P% a co 01 Ln r4 N F-4

1978 Diffuse Auroral Boundaries and a Derived Auroral Boundary Index

DTIC Science & Technology

1982-12-28

they have nothing to do with the auroral precipitation, they must be differentiated from the auroral electrons when determining boundaries. Due to the...47.8 -54.6 -61.4 -68.0 -74.2 -79.4 -81.7 -78.9 -73.5 - 7.2 -60.6 GLON 121.0 118.5 115 S 1114 105.3 95.0 74.69 37.7 352.2 332.? 323:.1 317:3 M1LAY -56.2...1IN NN 1 1 NI M- I II- IN - N1 C , S~li-o N nol- O) N.010 DTN440 W00CO0 10011aN IIU0 )0 r,0 0 N0 t N1e . 0 MC0t)O0 r- ,J o 110 00 toC 0 0010 01 0t n 1

Description and Use of the Plume Radiation Code ATLES

DTIC Science & Technology

1977-05-13

CONTAINED IN THIS DOCUMENT ARE THOSE 2OF THE AUTHORS AND SHOULD NOT BE INTERPRETED AS NECESSARILY REPRESENTING THE OFFICIAL POLICIES , EITHER EXPRESSED OR...0 o N C?) -4 0 N N cnCD 0 C0 0 *N N N N R N N N I N N N N A V A V A V V V V A V V V V 40 0 )0 0 00 cn 0 C 0 ON M N3 VA A A i * 0 C) )c C ’V0 N 0 N: C

Response Protocol Toolbox: Planning for and Responding to Drinking Water Contamination Threats and Incidents. Response Guidelines

DTIC Science & Technology

2004-08-01

sp ec if ic ra d io n u cl id es 9 0 0 S er ie s 3 2 In te ri m F in al – A u g u st 2 0 0 4 R E S...in je ct io n , h ea d sp ac e S ee M o d u le 4 A n a ly si s: G C /M S , G C , H P L C , L C -M S U n k n o w n in o rg an ic s 1 L...er f o r th e m et er o r k it u se d d u ri n g s

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 11. (Kalidescope Shipping, Inc.-Lous Electronics)

DTIC Science & Technology

1989-01-01

0 ( 0 - ( 0 q I - 0 5 0 ) I WOON It -4Z r-44- 5 -N40 142 it I COC of 0I I 000 H9 is :i mo 000 111.~-D~ 0 : It -L -4 moo -4 - C I) N-4...LA 0 0 ɜif IN " 0 1- 0 2 0 LAI 0 0 1- w 1- 2 1-- 1 : I N 11 5 -4 ൾ w c-c M 1.- 0 0 c < Xf. 0 )112E I) D0 01 01 U) Q 0 ) C 0 0 -~ 0 f- i- w 11 z I) iia...8217),- N m - 0 ( 0

Trunk extensor and flexor strength of long-distance race car drivers and physically active controls.

PubMed

Baur, Heiner; Muller, Steffen; Pilz, Frederike; Mayer, Patrizia; Mayer, Frank

2010-09-01

Seventy percent of motor sports athletes report low back pain. Information on the physical capacity of race car drivers is limited. The purpose of this study was to compare the maximum trunk extensor and flexor strength of elite race car drivers and physically active controls. Thirteen elite race car drivers and 13 controls were measured in concentric mode for maximal trunk flexion and extension at 60° x s(-1) and 120° x s(-1). Peak torque (mean ± s) at 60° x s(-1) in trunk extension was 283 ± 80 N x m in the drivers and 260 ± 88 N x m in controls (P > 0.05). At 120° x s(-1), drivers produced peak torques of 248 ± 55 N x m compared with 237 ± 74 N x m for controls (P > 0.05). Peak torques in flexion were less than in extension for both groups (60° x s(-1): drivers 181 ± 56 N x m, controls 212 ± 54 N x m, P > 0.05; 120° x s(-1): drivers 191 ± 57 N x m, controls 207 ± 48 N x m, P > 0.05). Individual ratios of flexion to extension forces exhibited ratios of 0.88 (60° x s(-1)) and 0.93 (120° x s(-1)) for controls and 0.66 (60° x s(-1)) and 0.77 (120° x s(-1)) for drivers (60° x s(-1): P > 0.05; 120° x s(-1): P > 0.05). The maximum strength performance capacity of the trunk muscles of elite motor sport athletes competing in long-distance racing did not differ from that of anthropometrically matched and physically active controls.

Air Force Office of Scientific Research (AFOSR) Technical Report Summaries

DTIC Science & Technology

1991-01-01

L Lu -i I M .’Z41 (a ZO-411 , 01(Kl~a 0 0 at. 0 90𔃺. 444 W4 LU 4". 14 LL. -C4 .4 -- In in1.0 0-4 14 0 43 - L C43(43xW vin 3 . 4’ a4 C4 - 4 . C 04... Vin -: 3 ~L 0q F U -. Nr 0 n0 (A.C iCU’CE M- U -ULO 0.ZLi -@3w 2 D@ 0 0 0’ -3C’-ul C U - W 4@- ~N Lu (A:U’xC -2r M N(D~ 0 0 L -- L C E CL4 in 04. I

Medición de los parámetros cosmológicos q0, ΩM, y ΩΛ, usando supernovas de Tipo Ia distantes

NASA Astrophysics Data System (ADS)

Clocchiatti, A.; High-Z Sne Search Team

Las supernovas de tipo Ia son una herramienta de gran precisión para la medición de distancias de interés cosmológico. Los métodos recientes de calibración de su luminosidad intrínseca, que hacen uso de la forma de las curvas de luz en varios colores y permiten diferenciar entre supernovas distantes, intrínsecamente débiles, u oscurecidas por extinción, reducen la dispersión del método que las asume de magnitud absoluta constante de 0.50 mag a 0.15 mag, e incrementa el valor de la constante de Hubble de ~55 km s-1 Mpc-1, a 65 km s-1 Mpc-1. A partir de la calibración de las supernovas cercanas, con redshifts menores que 0.1, se pueden obtener distancias precisas a supernovas que explotan a alto redshift. Hemos aplicado estos métodos a 16 supernovas con 0.16 < Z < 0.97, encontrando que sus distancias son, en promedio, entre 10% y 13% (dependiendo del método empleado) mayores que las que uno esperaría en un universo con poca masa (Ω = 0.2), sin una constante cosmológica. Todos los métodos de ajuste de curvas de luz, y selección de subgrupos de la muestra de supernovas observadas, favorecen consistentemente modelos del universo que se expanden eternamente y que tienen una constante cosmológica positiva (ΩΛ > 0), y una aceleración de la expansión al presente (q0 < 0). Hay distintas fuentes de posibles errores sistemáticos que merecen ser analizadas, entre ellas: evolución de la metalicidad y estrellas progenitoras, extinción, bias en la elección de la muestra, amplificación por gravitational lensing, y contaminación de la muestra. Ninguno de estos efectos alcanza para reconciliar los datos con ΩΛ = 0, o q0 > 0.

Synthèses et supraconductivité de monocristaux à base de mercure

NASA Astrophysics Data System (ADS)

Pelloquin, D.; Villard, G.; Hardy, V.; Maignan, A.; Raveau, B.

1998-01-01

Single crystals (n = 1, 2 and 3) of the Hg_{l-x}M_xBa_2Ca_{n-1}Cu_n O_{2n+2+δ} mercury based cuprates have been grown by using a simple process. The M cations (M = Bi, Cu, Ti) act as stabilizers of the structure which permit to avoid the use of dry box or high gas pressure. The electron microscopy coupled with EDX analyses evidence the regularity of the stacking mode and confirm mixed mercury layers with compositions close to Hg_{0.8} M_{0.2}. Their structural studies based on X-ray diffraction data show a splitting of the oxygen site at the level of the mixed mercury layer. These as-grown superconducting single crystals exhibit T_c close to that of the corresponding pure mercury ceramics. The pinning properties study performed on (Hg_{0.8}Bi_{0.2}) crystals confirms that the n = 1 member is intermediate between the n = 2 and n = 3 members. Moreover, the weak properties of the Hg_{0.6}Ti_{0.4}{-}1223 crystals with regard to the Hg_{0.8}Bi_{0.2}{-}1223 crystals suggest that their different cationic radii Hg/M and their different c-axis values may play a role on these properties. Une méthode de synthèse simple, permettant de faire croître des monocristaux de composition Hg_{l-x}M_xBa_2Ca_{n-1}Cu_n O_{2n+2+δ} (n = 1, 2 et 3) sans utiliser de boîte à gants ou de techniques sous hautes pressions, a été developpée en substituant partiellement le mercure par un cation M (M = Bi, Cu, Ti). Des études par microscopie électronique couplées avec des analyses EDX ont confirmé les modes d'empilement et l'introduction de 1'é1ément M sous la forme de couches mixtes Hg_{0,8}M_{0,2}. Les études structurales réalisées par diffraction de rayons X sur monocristal ont mis en évidence un éclatement du site oxygène lié à la couche mercure. Ces monocristaux, bruts de synthèses, présentent des T_c comparables à celles observées dans les céramiques "tout mercure” correspondantes. L'étude des propriétés d'ancrage des vortex, menée sur les cristaux dopés au bismuth, confirme la position intermédiaire du terme n = 1 par rapport aux termes n = 2 et n = 3. De plus, une comparaison entre les cristaux de type 1223 (n = 3) dopés successivement au titane (Hg_{0,6}Ti_{0,4}{-}1223) et au bismuth (Hg_{0,8}Bi_{0,2}{-}1223) semble mettre en avant les valeurs du rapport Hg/M et du paramètre c sur ces propriétés.

Nonlinear Regression Analysis Methodology for the Estimation of Detection Probabilities from Empirical Data.

DTIC Science & Technology

1982-09-01

0 4-. w- c . 44U- - E lb . J -i.. ’..i en * 1 00 OWWW.e 0 o- WAW 0 - z 0 w 0 . en w --O znlb0ee. -en 49 -j w w m -a 0 0 ;; 5 , ~ , 4Ai 4Z P-- 0 ’a a...tlb - u 2j 00.UU 0 - ~ . - X z~Z~u en O-~.. C m 4 W 4 2 - . CL0 a. 4L . ZZ"ZU.JO-.U A- 5 -. N. m. 40 t-~ t- t- .t- t-ILL o.c v t. Ma mm x In0 00 I I...C! C! r! .! C! r! 47 ir !C .1I I ID* SU . 0 U, U . .(3 W1t 0 - 4A o~ 5 a% IT00mt i nU n C z 4n 0 ~ o D in

Prime Contractors with Awards Over $25,000 by Name, Location, and Contract Number, Fiscal Year 1992 (Daubert Industries, Inc.-Gaylord Industries, Inc.)

DTIC Science & Technology

1993-01-01

a0 m~ ar (0 - a 0 a4 04 H50 4 a 4 C-1 am a C3 L) 0ý an 0 a n c Za4 00 C.ým 4Lo j I N O Nol 0IS)0 cl r- m - anNe t"I ý ý Ll2 an N -z Do~ acca -fN- 0a’J...c to aQ Coo," I "o o) " ’ mC, ,I e nnI to a) ammc)oc Il I I L) o c wo x I Ca u m2 a. U r-7f cc ~ nl.< C0C) -*4~-0na-ao " 0 ELI ao (v acCa ’’ a~al~ nal...Fw IE~ 1. E F1 F4 o F. c4I F 4 F OF. F7 )I - F ~-4 .F 4 F 41) w 10 A F F W)( o4 v7- m ’mo7 l T =444 45 o o .7 c> S . o Lc4 mo - 04 NNr a)0 lo 7 1 7 o

A Damage Assessment Model for Surface Engagement for Missile and Gunfire.

DTIC Science & Technology

1982-03-01

characteristics make war games perhaps the only medium available, short of war, efficient enough for evalua- ting and examining command decisions at every level ...NP4-(NNNc enmW)" 1000 04 if2=A as O4 920331:91 52 *w:( 0n 0 % %*~ L 00000 0 t t h. 0 Cc SLLM v-%aeVI%0% 0C* 0 0% % 0 m % %0 4b. 0 0 I4qNenc 0 __ 0 4r...cDUnh 04 %W H 11 ACUE40% %N-o 0 0 090 hiit t (MCD hit c-4 m-N’-o m tI i 10 0t i4Nt a6 HLMm0~ *as oil wa a to 910 164 mcq %%% c 𔃺.~ i Nmf’ImP*2 v it

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 8 (Electronic Design Inc-Florida North Shipyards)

DTIC Science & Technology

1990-01-01

8217- " -" 0 Li A- (:4 Li DC 0 2- 0 U Lic U) D I-- I: Ia 10N II U) Fd - > 2 .~ H C4 " 0)4 -4 < 1 1 <- w 0 Z II - CON 11 W LiJ w Lij 2 Li z44 0 0 < <. 4CC) < Li...04 0C(1 L a 0-4 40> 0 a0c0𔃺a4(N(N(1(’ -CN n -4 " C -00CI -1 (0 M a - 00 M 1.0 C 0 it cd I CON it .LJO C>O ct)00( ~ CaO (D 0 <!> cc.Cc 0)00 a~ O)CO...11 I 4 C )( DC 4- - CON -1 -1N --010001-N-4 4 n-1- 4 1--- 4 -0-4- 400 1 1- - D( ,Z 11 I CN (I "N )CC 0 (D DC000,0(0C 00 0 0 00 0 0 0 000C.a0D<DD I C000

Nasal continuous positive airway pressure (n-CPAP) does not change cardiac output in preterm infants.

PubMed

Moritz, Barbara; Fritz, Michael; Mann, Christian; Simma, Burkhard

2008-02-01

Our objective was to study how invasive mechanical ventilation impairs cardiac output (CO) in children and adults. Although the application of continuous positive airway pressure (CPAP) is widely practiced in neonatal intensive care, its hemodynamic consequences have not yet been investigated. A prospective study to assess the hemodynamic effects was conducted in 21 preterm infants < 1500 g using two-dimensional M-mode and pulsed Doppler echocardiography during and 1 hour after discontinuation of nasal CPAP (n-CPAP). Gestational age was 28.0 +/- 1.9 weeks (mean +/- standard deviation); birthweight, 1000 +/- 238 g; age at study entry, 200 +/- 155 hours; total maintenance fluid, 154 +/- 42 mL/kg/day; and n-CPAP level, 4.4 +/- 0.9 cm H(2)O. None of the infants received inotropic support, and n-CPAP did not cause any significant difference in the parameters measured: stroke volume, 3.1 +/- 1.0 mL (with n-CPAP) versus 3.1 +/- 1.0 mL (without n-CPAP); cardiac output, 487 +/- 156 mL/minute versus 500 +/- 176 mL/minute; left ventricular diastolic diameter, 1.22 +/- 0.15 cm versus 1.24 +/- 0.14 cm; fractional shortening, 0.30 +/- 0.05% versus 0.29 +/- 0.04%; and aortic velocity-time integral, 8.64 +/- 1.80 cm versus 8.70 +/- 1.65 cm. The n-CPAP level did not influence CO; n-CPAP (up to 7 cm H (2)O) has no echocardiographically detectable hemodynamic effect in preterm infants. Our data imply there is no need to withhold n-CPAP support to prevent circulatory compromise in these infants.

Defect reduction of SiNx embedded m-plane GaN grown by hydride vapor phase epitaxy

NASA Astrophysics Data System (ADS)

Woo, Seohwi; Kim, Minho; So, Byeongchan; Yoo, Geunho; Jang, Jongjin; Lee, Kyuseung; Nam, Okhyun

2014-12-01

Nonpolar (1 0 -1 0) m-plane GaN has been grown on m-plane sapphire substrates by hydride vapor phase epitaxy (HVPE). We studied the defect reduction of m-GaN with embedded SiNx interlayers deposited by ex-situ metal organic chemical vapor deposition (MOCVD). The full-width at half-maximum values of the X-ray rocking curves for m-GaN with embedded SiNx along [1 1 -2 0]GaN and [0 0 0 1]GaN were reduced to 528 and 1427 arcs, respectively, as compared with the respective values of 947 and 3170 arcs, of m-GaN without SiNx. Cross-section transmission electron microscopy revealed that the basal stacking fault density was decreased by approximately one order to 5×104 cm-1 due to the defect blocking of the embedded SiNx. As a result, the near band edge emission intensities of the room-temperature and low-temperature photoluminescence showed approximately two-fold and four-fold improvement, respectively.

Formation of N-nitrosodimethylamine (NDMA) by ozonation of dyes and related compounds.

PubMed

Oya, Masami; Kosaka, Koji; Asami, Mari; Kunikane, Shoichi

2008-12-01

Formation of N-nitrosodimethylamine (NDMA) by ozonation of commercially available dyes and related compounds was investigated. Ozonation was conducted using a semi-batch type reactor, and ozone concentration in gas phase and the ozone gas flow were 10 mg L(-1) and 1.0 L min(-1), respectively. NDMA was formed by 15 min of ozonation of seven out of eight selected target compounds (0.05 mM) at pH 7. All the target compounds with N,N-dimethylamino functions were NDMA precursors in ozonation. The lowest and highest NDMA concentrations after ozonation of the target compounds were 13 ng L(-1) for N,N-dimethylformamide (DMF) and 1600 ng L(-1) for N,N-dimethyl-p-phenylenediamine (DMPD), respectively. NDMA concentrations after 15 min of ozonation of 0.05 mM methylene blue (MB) and DMPD increased with an increase in pH in its range of 6-8. The effects of coexisting compounds on NDMA concentrations after 15 min of ozonation of 0.05 mM MB and DMPD were examined at pH 7. NDMA concentrations after ozonation of MB and DMPD increased by the presence of 0.05 mM (0.7 mg L(-1) as N) nitrite (NO(2)(-)); 5000 ng L(-1) for MB and 4000 ng L(-1) for DMPD. NDMA concentration after MB ozonation decreased by the presence of 5mM tertiary butyl alcohol (TBA), a hydroxyl radical (HO.) scavenger, but that after DMPD ozonation was increased by the presence of TBA. NDMA concentrations after ozonation of MB and DMPD were not affected by the presence of 0.16 mM (5.3 mg L(-1)) hydrogen peroxide (H(2)O(2)). When 0.05 mM MB and DMPD were added to the Yodo and Tone river water samples, NDMA concentrations after 15 min of their ozonation at pH 7 increased compared with those in the case of addition to ultrapure water samples.

Numerical Studies of the Radiation Condition at the Inlet of a Transonic Compressor Blade Row.

DTIC Science & Technology

1980-04-01

284-296 (1977). 2 aL.) ITH~rOU7 REFLECTOAJ &RWD b)WITH PJEFL.ECr-IOA, FIGLJ/AE I NV9 PATTERNhS EXPEC TED located a chord length or so upstream of the...C) W In -0N -W e --N 0 -00 e -’N -" M-M M V -NM ""NM N NM 0 - - - - - - - - - - - - --4 WUN NWCON NMWN NN VN N-CYN N N NOJcyN N-N N-N N O~j N 000 00

Ultrasensitive Infrared Chemiluminescence Detection

DTIC Science & Technology

1993-10-01

avelengt (14M) 2.01 1 NO Fundamental (Av-2) 2-0 3-1 S1.0 N(WA.fl Ŕ 4-1 5-2 0.0 2.0 2.5 3.0 3.5 4.0 Wavelength (urn) 42 NX -in Nowo cc E 0 Imt 𔃺 poz ow...2 p _4S) 347 nm INTENSITY AS A FUNCTION OF [N( 2 P)] T-5216 3.0 2.5 - 2.0- •. 1.5’- 0. S1.0 0.5 0.0 0 1 2 3 4 5 6 7 [N(2P)J (1011 atoms cm-3) 8-74M...observing the forbidden N( 2P- 4S) emission at 347 nm. The rate coefficient for N(ZP) quenching by 02 is (2.2 *0.4) x 10 cm3 molecule-I s-I and that

Prime Contract Awards Alphabetically by Contractor, State or Country, and Place. Part 11 (Lemmon Company, Sellersville Pennsylvania - McEwen Construction, Beale AFB, California), FY1991

DTIC Science & Technology

1991-01-01

Mw N1 -.44 N 0000 0a a I IS -40 UA 00000000000- P- 1 0 WOO 0 -404 0N 0 U-4: 5 -4to U 0 C4N N N 0044044 .4 w4.4 .4 ..4-4 -4 ~ (’ C m C. U-4 W U-4N U1...ininO4Nsio 0 in0 0) ON4CS in 0000 4V In ( wo U 0 -44! in W 14 01V- -4-4.4 N00r -4 .4 -4.50 U 4 0OO 0 -4-4 NM in N4 U> O- :i00 U 1 %. 1 woo00 U .4 U...40O0 in wU1444 30 0o I0 U46- 1I cd 0 U )4444444 C in 000 0 L- 1 - 4o in 0000 er- int N 0I1 COCO U .A140NNNNNN min 000C -of- ’C00 0-4 m.C1-r1 win 04

Greenhouse gas fluxes from salt marshes exposed to chronic nutrient enrichment

USGS Publications Warehouse

Chmura, Gail L.; Kellman, Lisa; van Ardenne, Lee; Guntenspergen, Glenn R.

2016-01-01

We assessed the impact of nutrient additions on greenhouse gas fluxes using dark static chambers in a microtidal and a macrotidal marsh along the coast of New Brunswick, Canada approximately monthly over a year. Both were experimentally fertilized for six years with varying levels of N and P. For unfertilized, N and NPK treatments, average yearly CO2 emissions (which represent only respiration) at the microtidal marsh (13, 19, and 28 mmoles CO2 m-2 hr-1, respectively) were higher than at the macrotidal marsh (12, 15, and 19 mmoles m-2 hr-1, respectively, with a flux under the additional high N/low P treatment of 21 mmoles m-2 hr-1). Response of CH4 to fertilization was more variable. At the macrotidal marsh average yearly fluxes were 1.29, 1.26, and 0.77 μmol CH4 m-2 hr-1 with control, N, and NPK treatments, respectively and 1.21 μmol m-2 hr-1 under high N/low P treatment. At the microtidal marsh CH4fluxes were 0.23, 0.16, and -0.24 μmol CH4 m-2 hr-1 in control, N, and NPK and treatments, respectively. Fertilization changed soils from sinks to sources of N2O. Average yearly N2O fluxes at the macrotidal marsh were -0.07, 0.08, and 1.70, μmol N2O m-2 hr-1 in control, N, NPK and treatments, respectively and 0.35 μmol m-2 hr-1 under high N/low P treatment. For the control, N, and NPK treatments at the microtidal marsh N2O fluxes were -0.05, 0.30, and 0.52 μmol N2O m-2 hr-1, respectively. Our results indicate that N2O fluxes are likely to vary with the source of pollutant nutrients but emissions will be lower if N is not accompanied by an adequate supply of P (e.g., atmospheric deposition vs sewage or agricultural runoff). With chronic fertilization the global warming potential of the increased N2O emissions may be enough to offset the global cooling potential of the C sequestered by salt marshes.

Acquisition, Contracting/Manufacturing Job Series 0801, 0896, 1102, 1103, 1105, 1106, 1150, 1910

DTIC Science & Technology

1992-06-01

S TA TES 7AAIJR FORCE 0 OLPH AFS OCC UPA TIONA L SUR VEY REPOR T ELECT SEP2 8199 , A JOB SERIES 0801, 0896... a , ’ SM ad 140 ’ a 0 z z z U 4. 10 .4 -4 𔃺 .m L %T𔃺. .4 I 0 m 3w 44. Z ca l Ns 𔃺.40 0’ I I I s I I I 1 z 0 : ac SM z. %n a ol N IN N ’p 4 41 1 4 44...WA .4 I.-U. 0 Z 40 1- z ~ .4 .4 I @ 0 S I .4 I S I I I S N N I S iN .J N 00 cc " C0 LAI0U 0 0 z 0 z SM c 0 at.L z 04 u 0 0 zCC

All Prime Contract Awards by State or Country, Place, and Contractor, FY 88. Part 19. (Abington, Virginia - Yorktown, Virginia)

DTIC Science & Technology

1988-01-01

00( z Q I 40(1 I (0 C-1 (0 N-Np- -4 0) 11- (D(D (D LA Ln Ln m (n (70 -4 0) (D 044ɘ (1 10)N( 4AC 000 -4N- -.0 LADO C OOOONNNNOOOO q*0C0 400 W440(1Or...I4CD-4 0 I - ENC -4N CI I -INr~ .- ENNN "’-4NN4C1 -- ENC -4 1N cl -EN .4NC4 N 4 40M0O) I >NC >NN4 >NC’ >NNN S >NN, >N" >NC >NC >N4C > 4N I40000004 0 00 0...LI-00COW0 W I mocli IZOOOOOOOOOOOOUWIAOOO eNc - oco - ɘ wooocw - 0 CL I MON l0OOOOOOOOOOOmz u)O - -u -4 L) CL C) wzzzzmu I MO-4 1 1-1 < < 1-1 < < z

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, FY 85. Part 20 (Tokkey Uluslarararasi Naklejet - Video & Sealing Inc).

DTIC Science & Technology

1985-01-01

ON 0- -1r)- 04 N00O 1(0 1-4 -#.-44 nO P4I 4 N 04 0 4 -1-4C M’ 281 0 11. u. cc =ta0 ’ 4 m 1004 ANl.(( 0 -O -t3- 0 UN W 0( I ce I- .40 -4 -4 1-4 14 0000...000000 00 00 000 4- I IO NCVI 1 00 I J (SN - -l4 ICNCJ .. to I ZWI In I I xo.( -1i ouooooooooooooooooooooooooooooooooooooooooooooo W -04 0 to N N990= = ao...Y C)N A 0 -4 04 - 4 4- .4 0A l -00 , 4c (00 I gn S ) 01- 1-- U)-0cccn- 0n 40n N NN -4 N (INN C, in4Uan- z CD-q z zwi I (00j I C 0) -z -C’ NV 00ltet

Role of moxibustion in inflammatory responses during treatment of rat ulcerative colitis

PubMed Central

Han, Yang; Ma, Tie-Ming; Lu, Mao-Lin; Ren, Lu; Ma, Xian-De; Bai, Zeng-Hua

2014-01-01

AIM: To investigate the efficacy of moxibustion in ulcerative colitis (UC) rats from morphological, immunological and molecular biological perspectives. METHODS: Thirty-two Sprague-Dawley rats were randomly assigned to a blank control group (normal rats, n = 6) and a model replication (MR) group (UC rats, n = 26). A UC model was established by 2,4,6-trinitrobenzenesulfonic acid/dextran sulfate sodium enema. Rats in the MR group were further randomly assigned to a 9-min moxibustion (9M) group (9 moxa-cone, n = 6), 6-min moxibustion (6M) group (6 moxa-cone, n = 6), 3-min moxibustion (3M) group (3 moxa-cone, n = 6), and a waiting list control (WLC) group (no moxibustion treatment, n = 6). Rats in the moxibustion treatment group were treated in 14 sessions over 28 d. Disease activity, local tissue morphology, serum level of interleukin (IL)-8 and IL-10, and expression of Toll-like receptor (TLR)9 as well as nuclear factor (NF)-κB p65 in colonic tissue were determined by disease activity index (DAI), hematoxylin and eosin staining, electron microscopy, enzyme-linked immunosorbent assay and Western blotting, respectively. RESULTS: DAI was lowest in the 9M group and highest in the WLC group. The differences in DAI between the moxibustion treatment (3M, 6M, 9M) and no treatment groups were significant for all one-to-one comparisons (0.60 ± 0.54 vs 1.20 ± 0.44, 0.60 ± 0.54 vs 1.80 ± 0.45, 0.60 ± 0.54 vs 3.0 ± 0.45, respectively, P < 0.05). Light and electron microscopy showed that the neatness of the glandular arrangement in colonic mucosal epithelia gradually increased in the WLC, 3M, 6M to 9M groups. IL-8 level successively decreased while IL-10 level increased from the WLC to 3M, 6M and 9M groups. The differences among these groups were significant for all comparisons (105.46 ± 8.75 vs 76.61 ± 3.58, 105.46 ± 8.75 vs 69.78 ± 1.87, 105.46 ± 8.75 vs 67.41 ± 1.84, respectively, P < 0.01 for IL-8; and 30.83 ± 1.29 vs 75.64 ± 1.90, 30.83 ± 1.29 vs 80.90 ± 3.16, 30.83 ± 1.29 vs 83.46 ± 2.37, respectively, P < 0.01 for IL-10), except comparison of 6M vs 9M. Expression of TLR9 and NF-κB p65 decreased in order: highest in the WLC group and lowest in the 9M group. In addition, the differences among the WLC, 3M, 6M and 9M groups were significant for all comparisons (0.492 ± 0.026 vs 0.380 ± 0.022, 0.492 ± 0.026 vs 0.355 ± 0.005, 0.492 ± 0.026 vs 0.327 ± 0.015, respectively, P < 0.05 for TLR9; and 0.436 ± 0.041 vs 0.326 ± 0.022, 0.436 ± 0.041 vs 0.293 ± 0.006, 0.436 ± 0.041 vs 0.265 ± 0.017, respectively, P < 0.05 for NF-κB p65). CONCLUSION: Moxibustion repairs damaged colonic mucosa, suppresses serum IL-8, activates serum IL-10 level, and decreases expression of TLR-9 and NF-κB p65 in UC rats. PMID:25170214

Role of moxibustion in inflammatory responses during treatment of rat ulcerative colitis.

PubMed

Han, Yang; Ma, Tie-Ming; Lu, Mao-Lin; Ren, Lu; Ma, Xian-De; Bai, Zeng-Hua

2014-08-28

To investigate the efficacy of moxibustion in ulcerative colitis (UC) rats from morphological, immunological and molecular biological perspectives. Thirty-two Sprague-Dawley rats were randomly assigned to a blank control group (normal rats, n = 6) and a model replication (MR) group (UC rats, n = 26). A UC model was established by 2,4,6-trinitrobenzenesulfonic acid/dextran sulfate sodium enema. Rats in the MR group were further randomly assigned to a 9-min moxibustion (9M) group (9 moxa-cone, n = 6), 6-min moxibustion (6M) group (6 moxa-cone, n = 6), 3-min moxibustion (3M) group (3 moxa-cone, n = 6), and a waiting list control (WLC) group (no moxibustion treatment, n = 6). Rats in the moxibustion treatment group were treated in 14 sessions over 28 d. Disease activity, local tissue morphology, serum level of interleukin (IL)-8 and IL-10, and expression of Toll-like receptor (TLR)9 as well as nuclear factor (NF)-κB p65 in colonic tissue were determined by disease activity index (DAI), hematoxylin and eosin staining, electron microscopy, enzyme-linked immunosorbent assay and Western blotting, respectively. DAI was lowest in the 9M group and highest in the WLC group. The differences in DAI between the moxibustion treatment (3M, 6M, 9M) and no treatment groups were significant for all one-to-one comparisons (0.60 ± 0.54 vs 1.20 ± 0.44, 0.60 ± 0.54 vs 1.80 ± 0.45, 0.60 ± 0.54 vs 3.0 ± 0.45, respectively, P < 0.05). Light and electron microscopy showed that the neatness of the glandular arrangement in colonic mucosal epithelia gradually increased in the WLC, 3M, 6M to 9M groups. IL-8 level successively decreased while IL-10 level increased from the WLC to 3M, 6M and 9M groups. The differences among these groups were significant for all comparisons (105.46 ± 8.75 vs 76.61 ± 3.58, 105.46 ± 8.75 vs 69.78 ± 1.87, 105.46 ± 8.75 vs 67.41 ± 1.84, respectively, P < 0.01 for IL-8; and 30.83 ± 1.29 vs 75.64 ± 1.90, 30.83 ± 1.29 vs 80.90 ± 3.16, 30.83 ± 1.29 vs 83.46 ± 2.37, respectively, P < 0.01 for IL-10), except comparison of 6M vs 9M. Expression of TLR9 and NF-κB p65 decreased in order: highest in the WLC group and lowest in the 9M group. In addition, the differences among the WLC, 3M, 6M and 9M groups were significant for all comparisons (0.492 ± 0.026 vs 0.380 ± 0.022, 0.492 ± 0.026 vs 0.355 ± 0.005, 0.492 ± 0.026 vs 0.327 ± 0.015, respectively, P < 0.05 for TLR9; and 0.436 ± 0.041 vs 0.326 ± 0.022, 0.436 ± 0.041 vs 0.293 ± 0.006, 0.436 ± 0.041 vs 0.265 ± 0.017, respectively, P < 0.05 for NF-κB p65). Moxibustion repairs damaged colonic mucosa, suppresses serum IL-8, activates serum IL-10 level, and decreases expression of TLR-9 and NF-κB p65 in UC rats.

Official Guard and Reserve Manpower Strengths and Statistics. Fiscal Year 1982 Summary

DTIC Science & Technology

1982-01-01

DI ’a D~ U.. O 14( 11) f.IF) U0 0F)Cn D.4- F- aIaDP iDC n l 4. wlU a’ ý w fN 0 n C K) T) -P" F CW a l ) Nn w) (’o F-4 o( C...CIn OW~I ;0 - 4MT 4i on 0. H WI l - 0 PI4 .4C) .4i 4 4 N W’)NNP) t .’ P2-iP I flD N 4I LL. (F L0 Di0C )t Di YW 0 4 O %W nll)ýP ON sý4 )"C I LP ,I N 6...8217 V) 4K 1L 6; - N In 4ý v4 w4 O0a vC l 4440 4K 6K1 I DI 4’ tflLi 4M 49 ii 4. ;c 4i 0 W 4 M. wIL In 0q x~ 4i w. cc 4 4j 64 6 w0 ~ 0’Ir 0 .4’ m 4 V 4

Geographic List of Prime Contract Awards. Oct 1991 - Sep 1992. FY92. (Los Amigos California - San Jose California)

DTIC Science & Technology

1993-01-01

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Dollar Summary of Federal Supply Classification and Service Category by Company, FY 87. Part 10. 5955-6650

DTIC Science & Technology

1987-01-01

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Prime Contract Awards of $100,000 or More by Federal Supply Classification or Service Category and Purchasing Office. FY 87. Part 4. J095-S214.

DTIC Science & Technology

1987-01-01

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On the Ample Service Assumption of Palm’s Theorem in Inventory Modeling.

DTIC Science & Technology

1980-10-03

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Microcomputer Based Ship-Board Gun Control System.

DTIC Science & Technology

1981-03-01

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Gastric and hepatocellular carcinomas do not overexpress the same ribosomal protein messenger RNAs as colonic carcinoma.

PubMed

Barnard, G F; Staniunas, R J; Mori, M; Puder, M; Jessup, M J; Steele, G D; Chen, L B

1993-09-01

The levels of a number of ribosomal protein mRNAs are reported to be increased in human colon cancer. We have assessed whether selected ribosomal protein mRNAs are overexpressed in other gastrointestinal malignancies, namely gastric and hepatocellular carcinomas. Subtracted complementary DNA libraries were generated from paired samples of human (a) colorectal carcinoma minus adjacent normal colonic mucosa and (b) hepatocellular carcinoma minus adjacent normal liver. Screening of approximately 3% of these library clones determined that ribosomal protein mRNAs encoding L18 and L37 (not previously reported) and P0 and S6 were overexpressed in one or the other library. Their complementary DNA inserts were then used as probes to evaluate their expression in a larger number of paired tumor/normal surgical samples of human colonic, gastric, and hepatocellular carcinomas, by Northern hybridization. The mRNA signal was greater in the colonic carcinoma than in paired adjacent normal colonic mucosa in 38 of 42 cases for P0 [tumor/normal (T/N) ratio = 3.0 +/- 0.3, mean +/- SE, P < 0.001] (G. F. Barnard, R. J. Staniunas, S. Bao, K. Mafune, J. L. Gollan, G. D. Steele, Jr., and L. B. Chen, Cancer Res., 52: 3067-3072, 1992), in 25 of 28 cases for L18 (T/N ratio = 3.7 +/- 0.5, P < 0.001), in 27 of 28 cases for L37 (T/N ratio = 5.3 +/- 0.4, P < 0.001), and in 24 of 28 cases for S6 (T/N ratio = 3.1 +/- 0.5, P < 0.01). The level of mRNA overexpression of L18 and S6 did not correlate with the Dukes' stage of disease. In hepatocellular carcinoma samples, using the same four ribosomal protein complementary DNA probes, only P0 mRNA was significantly increased (T/N ratio = 2.8 +/- 0.4, n = 6, P = 0.047). In gastric carcinoma samples, none of these mRNAs was increased (mean T/N ratios = 0.9-1.2, n = 6). Therefore, gastric and hepatocellular carcinomas do not overexpress the same ribosomal protein mRNAs as do colonic carcinoma.

A Review of Parametric Oscillators and Mixers and an Evaluation of Materials for 2 - 6 micrometer Applications

DTIC Science & Technology

1974-07-01

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Geographic List of Prime Contract Awards. Oct 1992-Sep 1993. FY 1993. (Air Force Academy, Colorado-Washington, DC). Part 3

DTIC Science & Technology

1994-03-01

0 0 a a. aL OC I ccN( N NjN W4~)4l~4v)4 (4(Vf) qq nn %V) 4(4f) V) t4)m (W aN in(0cl N r bPP % Pr. .r% 4ý a. PI% N.r.r Pr%I. P.. r... ar..a r, .. P a...J4 It) 0 Ut00 .1 IfI WOW04 160.4 .4 -4.4 .4 .4C4n -4.-4.4 (n -4 N-4 N P, Ln W Lfl40q 4OD Y 0) -0. 0 M Cn6 6 100400 11. O ffa I W6 co0 o it >- iI U I

Military Dimensions of Communist Systems

DTIC Science & Technology

1988-06-01

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Geographic List of Prime Contract Awards. Oct 92-Sep 93. FY 93. (Amos, Kentucky-Montgomery County, Maryland). Part 6

DTIC Science & Technology

1994-03-01

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Prime Contract Awards Alphabetically by Contractor, State or Country, and Place. Part 13 (NCR Media Products Division, Rockville, Maryland - Picker International Inc, San Francisco, California), FY1991

DTIC Science & Technology

1991-01-01

report. the research , or credited with the content of the report. If editor or compiler, this should follow the name(s). Block 15. Number of Pages...10000 .4(0(0(0 >.FC.JNNNNNN-NN NNN M D(4a(01 r ,r c7 01l KfC I (0(04 4) .- 4 00 4 x0 c. M400(0)0 Xɘ)0 id >4 D4>(O0004 : r : ofK U q -4 (0# N l C-1...0)0 -I m-4-4 qw4 f- -It w 0 wNNNNw N0000 ww- 4C.5 - N0 , 1 I-41 0)I -4 II CI0 "" acwwn L)04)fL~OOOCOO~lfI0 0 0. if 𔃻 I 0).4 KfC )C )C C DL)I n6 C>~ C

Prime Contract Awards Alphabetically by Contractor, State or Country, and Place. Part 5 (Castle Stove Co Inc, Quincy, Illinois - Dyncorp, Wichita Falls, Texas), FY1991

DTIC Science & Technology

1991-01-01

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Air Force Office of Scientific Research. AFOSR Technical Report Summaries

DTIC Science & Technology

1993-06-01

0..’ w z CA W B mL& L53 )I-t in (3w - J 2.5 W 1I- C12 z. WJO -1 )-. U’.aW 64 1--2 0 .Z 9 0 F- ... w ’.LILOO 4z w W’ IL =Aw M 4%0 J.IZW w . u zw -jO...x &-~ a 4 5 i ɜ (A W CDI- #_ z U r) (j 𔃺 ’- )_ *𔃾 We. a:U IA. aL U 014 U ’A -2 m 0 0 I--U’ o n (A z- w ý4 0 #- $.- U’>- tD I.- z 40 I-. a: x 4z- 0Z...toMM CC 0In L~A001 L - - oc -n C’ -- n x C4 L W - M A ’- 0 l. -A LO C SLS 0&c 0 0 0 0. 0+ a14 SI 41 > -a:I 0 c 1X’ .0 m z tD a1 -_ 1 U 8-01 --. 81 00 C

The pulmonary pharmacology of [4-methoxy-N1-(4-trans-nitrooxycyclohexyl)-N3-(3-pyridinylmethyl)-1,3-benzenedicarboxamide] (2NTX-99), an anti-atherotrombotic compound with therapeutic potential in pathological conditions that target lung vasculature.

PubMed

Brivio, I; Buccellati, C; Fumagalli, F; Hodge, J; Casagrande, C; Folco, G C; Sala, A

2012-08-01

The pharmacological activity of 2NTX-99 ([4-methoxy-N1-(4-trans-nitrooxycyclohexyl)-N3-(3-pyridinylmethyl)-1,3-benzenedicarboxamide]) was investigated in vitro in the intact, rat pulmonary vasculature and in guinea pig airways. Rat lungs were perfused at constant flow and changes in vascular tone recorded. Challenge with the TXA₂ analogue 9,11-dideoxy-9α11α-methanoepoxy ProstaglandinF₂ (U46619, 0.5 μM) increased vessel tone (32.48±1.5 vs 13.13±0.56 mmHg; n=12). 2NTX-99 (0.1-100 μM; n=5), caused a concentration-dependent relaxation, prevented by 1H-[1,2,4]oxadiazolo[4,3,-a]quinoxalin-1-one (ODQ, 10 μM, n=4), an inhibitor of soluble guanylate cyclase. Acetylcholine (0.1-10 μM; n=3) and a reference NO-donor, isosorbide-5-mononitrate (5-100 μM; n=4), were ineffective. Intraluminal perfusion of washed human platelets (2 × 10⁸ cells/ml) increased intravascular pressure after challenge with arachidonic acid (AA, 2 μM; n=5), an increase abolished by acetylsalicylic acid and significantly reduced by 2NTX-99 (40 μM; n=5). TXB₂ in the lung perfusate was detected after platelet activation, 2NTX-99 inhibited TXA₂ synthesis (6.45±0.6 and 1.10±0.2 ng/ml, respectively). 2NTX-99 did not alter central or peripheral airway responsiveness to Histamine (0.001-300 μM; n=6), U46619 (0.001-3 μM, n=3) or LTD₄ (1 pM-1 μM; n=6). 2NTX-99 vasodilates the pulmonary vasculature via the release of nitric oxide (NO) and reduces intraluminal, AA-induced, TXA₂ formation. The combined activity of 2NTX-99 as an NO-donor and a TXA₂-synthesis inhibitor provides strong support for its potential therapeutic use in pathologies of the pulmonary vascular bed (e.g. pulmonary hypertension). Copyright © 2012 Elsevier Inc. All rights reserved.

Temperature dependence and GABA modulation of (TH)triazolam binding in the rat brain

DOE Office of Scientific and Technical Information (OSTI.GOV)

Earle, M.E.; Concas, A.; Wamsley, J.K.

1987-07-27

The hypnotic triazolam (TZ), a triazolobenzodiazepine displays a short physiological half life and has been used for the treatment of insomnia related to anxiety states. The authors major objectives were the direct measurement of the temperature dependence and the gamma-aminobutyric acid (GABA) effect of (TH)TZ binding in the rat brain. Saturation studies showed a shift to lower affinity with increasing temperatures (K/sub d/ = 0.27 +/- 08 nM at 0C; K/sub d/ = 1.96 +/- 0.85 nM at 37C) while the B/sub max/ values remained unchanged (1220 +/- 176 fmoles/mg protein at 0C and 1160 +/- 383 fmoles/mg protein atmore » 37C). Saturation studies of (TH)TZ binding in the presence or absence of GABA (100 M) showed a GABA-shift. At 0C the K/sub d/ values were (K/sub d/ = 0.24 +/- 0.03 nM/-GABA; K/sub d/ = 0.16 +/- 0.04/+GABA) and at 37C the K/sub d/ values were (K/sub d/ = 1.84 +/- 0.44 nM/-GABA; K/sub d/ = 0.95 +/- 0.29 nM/+GABA). In contrast to reported literature, the authors findings show that TZ interacts with benzodiazepine receptors with a temperature dependence and GABA-shift consistent with predicted behavior for benzodiazepine agonists. 20 references, 3 tables.« less

Geographic List of Prime Contract Awards. Oct 91 - Sep 92. FY92. (Nanticoke Maryland - Garden City Michigan)

DTIC Science & Technology

1993-01-01

N4 ._ K MWL0.I- It 0o 00 10 0 0 00-40000 -04 0 (nK 00M0 a >- 22 Z 22222 z zzz z R nowo u 0 cow0 Q 4040040404 0 40404 40 If I001- a 04C 0ɜ 0 0 04 04.4...W40ld 00000I -4-000 C> 0 C000o1.170 1-00 -4 X I ( 1 010-4 1 0):C 0)~ Y- 40oO -4(0(0 oxZZ-j 0000 0-I -f) 347 M. Hf 4 5 00-4 if0)0 04 4000 04V)(󈨋) (7< <) 4...00000000’cJa 40C0,ln)00 Af I M02000 it vlwt"A4 (0 NOWO -t4--4-No )0) )NN0)I)1l00D0-40-I)0 -40D-𔃺C’.I002C-4 of I M0C000 ofiil -f 00 nn)U0f4 ~ aiN)noo~0)t

Heat flow in western Virginia and a model for the origin of thermal springs in the folded Appalachians

DOE Office of Scientific and Technical Information (OSTI.GOV)

Perry, L.D.; Costain, J.K.; Geiser, P.A.

1979-11-10

Five new heat flow values in the Blue Ridge (37/sup 0/02'N, 80/sup 0/12'W), Valley and Ridge (38/sup 0/00'N, 79/sup 0/50'W; 37/sup 0/54'N, 79/sup 0/54'W; 38/sup 0/14'N, 79/sup 0/49'W), and Alleghany Plateau (37/sup 0/12'N, 82/sup 0/06'W) provinces of Virginia are 36.3 +- 1.3mW/m/sup 2/, 317 +- 20mW/m/sup 2/, 48.2 +- 0.3mW/m/sup 2/, 49.5 +- 1.5mW/m/sup 2/, and 55.8 +- 1.7mW/m/sup 2/, respectively. The value of 36.3mW/m/sup 2/ in the Blue Ridge agrees with values predicted by the contour map of Sass et al. (1976) for this part of the eastern United States; the values of 49.5 and 48.3mW/m/sup 2/ in themore » Valley and Ridge province do not. The high value of 317 +- 20mW/m/sup 2/ at Hot Springs, Virginia, is the result of convection along a fault zone and is not regionally representative. The value of 48.3mW/m/sup 2/ determined at a site about 8 km southwest of Hot Springs, Virginia, is regionally representative of the heat flux. New data support a model of moderately deep circulation of meteoric water entering near-vertical sedimentary beds at relatively high topographic elevations and circulating downward via bedding plane permeability and fractures within Silurian quartzites and/or adjacent carbonate units. The moderately deep circulation is then intersected by vertical transverse linear fracture zones along which the water rises. All of the warm springs are located adjacent to topographic gaps which have developed along zones of weakness associated with the transverse fracture zones.« less

Prebiotic formation of 'energy-rich' thioesters from glyceraldehyde and N-acetylcysteine

NASA Technical Reports Server (NTRS)

Weber, A. L.

1984-01-01

The 'energy-rich' thioester, N-acetyl-S-lactoylcysteine, is formed from low concentrations of glyceraldehyde and N-acetylcysteine under anaerobic conditions at ambient temperature in aqueous solutions of sodium phosphate (pH 7.0). Reactions with 2mM glyceraldehyde, 2mM N-acetylcysteine, and 500 mM sodium phosphate (pH 7.0) convert about 0.3 percent/day of the glyceraldehyde to lactoyl thioester. The formation of lactoyl thioester in similar reactions with 500 mM imidazole hydrochloride (pH 7.0) is supported by the thiol-dependence of lactate formation, which is 3-fold greater in the presence of thiol (0.11 percent/day) than in the absence of thiol (0.04 percent/day). The formation of lactoly thioester is thought to proceed by the phosphate (or imidazole)-catalyzed dehydration of glyceraldehyde, which adds to the thiol to form a hemithioacetal that rearranges to the thioester. A limited amount of a second thioester, N-acetyl-S-glyceroyl-cysteine, is also formed at the beginning of these reactions. The significance of these reactions to the origin of life is discussed.

Prebiotic formation of `energy-rich' thioesters from glyceraldehyde and N-acetylcysteine

NASA Astrophysics Data System (ADS)

Weber, Arthur L.

1984-03-01

The ‘energy-rich’ thioester, N-acetyl-S-lactoylcysteine, is formed from low concentrations of glyceraldehyde and N-acetylcysteine under anaerobic conditions at ambient temperature in aqueous solutions of sodium phosphate (pH 7.0). Reactions with 2 mM glyceraldehyde, 2 mM N-acetylcysteine, and 500 mM sodium phosphate (pH 7.0) convert about 0.3%/day of the glyceraldehyde to lactoyl thioester. The formation of lactoyl thioester in similar reactions with 500 mM imidazole hydrochloride (pH 7.0) is supported by the thiol-dependence of lactate formation, which is 3-fold greater in the presence of thiol (0.11%/day) than in the absence of thiol (0.04%/day). The formation of lactoyl thioester is thought to proceed by the phosphate (or imidazole)-catalyzed dehydration of glyceraldehyde to give pyruvaldehyde, which adds to the thiol to form a hemithioacetal that rearranges to the thioester. A limited amount of a second thioester, N-acetyl-S-glyceroyl-cysteine, is also formed at the beginning of these reactions. The significance of these reactions to the origin of life is discussed.

Clinical observations on the treatment of prolapsing hemorrhoids with tissue selecting therapy

PubMed Central

Wang, Zhi-Gang; Zhang, Yong; Zeng, Xian-Dong; Zhang, Tie-Hui; Zhu, Qi-Dong; Liu, De-Long; Qiao, Yun-Yu; Mu, Nan; Yin, Zhi-Tao

2015-01-01

AIM: To compare the effects and postoperative complications between tissue selecting therapy stapler (TST) and Milligan-Morgan hemorrhoidectomy (M-M). METHODS: Four hundred and eighty patients with severe prolapsing hemorrhoids, who were admitted to the Shenyang Coloproctology Hospital between 2009 and 2012, were randomly divided into observation (n = 240) and control (n = 240) groups. Hemorrhoidectomies were performed with TST in the observation group and with the M-M technique in the control group. The therapeutic effects, operation security, and postoperative complications in the two groups were compared. The immediate and long-term complications were assessed according to corresponding criteria. Pain was assessed on a visual analogue scale. The efficacy was assessed by specialized criteria. The follow-up was conducted one year after the operation. RESULTS: The total effective rates of the observation and control groups were 99.5% (217/218) and 98.6% (218/221) respectively; the difference was not statistically significant (P = 0.322). Their were significant differences between observation and control groups in intraoperative blood loss (5.07 ± 1.14 vs 2.45 ± 0.57, P = 0.000), pain (12 h after the surgery: 5.08 ± 1.62 vs 7.19 ± 2.01, P = 0.000; at first dressing change: 2.64 ± 0.87 vs 4.34 ± 1.15, P = 0.000; first defecation: 3.91 ± 1.47 vs 5.63 ± 1.98, P = 0.001), urine retention (n = 22 vs n = 47, P = 0.001), anal pendant expansion after the surgery (2.35 ± 0.56 vs 5.16 ± 1.42, P = 0.000), operation time (18.3 ± 5.6 min vs 29.5 ± 8.2 min, P = 0.000), and the length of hospital stay (5.3 ± 0.6 d vs 11.4 ± 1.8 d, P = 0.000). Moreover TST showed significant reductions compared to M-M in the rates of long-term complications such as fecal incontinence (n = 3 vs n = 16, P = 0.003), difficult bowel movement (n = 1 vs n = 9, P = 0.011), intractable pain (n = 2 vs n = 12, P = 0.007), and anal discharge (n = 3 vs n = 23, P = 0.000). CONCLUSION: TST for severe prolapsing hemorrhoids is a satisfactory technique for more rapid recovery, lower complication rates, and higher operation security. PMID:25741159

Clinical observations on the treatment of prolapsing hemorrhoids with tissue selecting therapy.

PubMed

Wang, Zhi-Gang; Zhang, Yong; Zeng, Xian-Dong; Zhang, Tie-Hui; Zhu, Qi-Dong; Liu, De-Long; Qiao, Yun-Yu; Mu, Nan; Yin, Zhi-Tao

2015-02-28

To compare the effects and postoperative complications between tissue selecting therapy stapler (TST) and Milligan-Morgan hemorrhoidectomy (M-M). Four hundred and eighty patients with severe prolapsing hemorrhoids, who were admitted to the Shenyang Coloproctology Hospital between 2009 and 2012, were randomly divided into observation (n=240) and control (n=240) groups. Hemorrhoidectomies were performed with TST in the observation group and with the M-M technique in the control group. The therapeutic effects, operation security, and postoperative complications in the two groups were compared. The immediate and long-term complications were assessed according to corresponding criteria. Pain was assessed on a visual analogue scale. The efficacy was assessed by specialized criteria. The follow-up was conducted one year after the operation. The total effective rates of the observation and control groups were 99.5% (217/218) and 98.6% (218/221) respectively; the difference was not statistically significant (P=0.322). Their were significant differences between observation and control groups in intraoperative blood loss (5.07±1.14 vs 2.45±0.57, P=0.000), pain (12 h after the surgery: 5.08±1.62 vs 7.19±2.01, P=0.000; at first dressing change: 2.64±0.87 vs 4.34±1.15, P=0.000; first defecation: 3.91±1.47 vs 5.63±1.98, P=0.001), urine retention (n=22 vs n=47, P=0.001), anal pendant expansion after the surgery (2.35±0.56 vs 5.16±1.42, P=0.000), operation time (18.3±5.6 min vs 29.5±8.2 min, P=0.000), and the length of hospital stay (5.3±0.6 d vs 11.4±1.8 d, P=0.000). Moreover TST showed significant reductions compared to M-M in the rates of long-term complications such as fecal incontinence (n=3 vs n=16, P=0.003), difficult bowel movement (n=1 vs n=9, P=0.011), intractable pain (n=2 vs n=12, P=0.007), and anal discharge (n=3 vs n=23, P=0.000). TST for severe prolapsing hemorrhoids is a satisfactory technique for more rapid recovery, lower complication rates, and higher operation security.

Official Guard and Reserve Manpower Strengths and Statistics: Fiscal Year 1988 Summary

DTIC Science & Technology

1988-09-01

o r m r c ,( n c , m r n V AC>A C AC 𔃾 𔃾 D4 N in c4nr) D c nr n L r o a 2 r lm 0 0 r , ACOA AC AC 𔃾 N qN------ ACCA ~rAC A WC& A OC A AC 0l 00 AC...3 * 3$ 0n 44 &L * * 3 r ci o DCA I L0 W3 . 0K Id N0 P7 10 gr x 3 0. 3l IT 3. ilG a- 3l IT 3r AA 33An4 W0 .-4 -l 10 0.0’ 0 43 wZ 0 Id NVN N4 01 0I T a...1 n a 0. to 0303 r o 3s 3N3N I 3 >’ 3 1 31L 4 3430u 9 343 3e 3300>L ~ 3 3 3 3azc 3183 3 4 > 0 00 N, 4 4 P7 Il𔃾’ 3-8 3L 3i 0>I-x4C 3 t.4 3J 331. 3 3

Dollar Summary of Prime Contract Awards by State, Place, and Contractor. Part 3 (Adrian, Michigan-Yamhill, Oregon)

DTIC Science & Technology

1989-01-01

oi ii VIc - w : < Ŕ- z I 00UL. 0 (0 C~0ə in 1r~- 0 "n af 011< 0-4 X" x 21u < o .- w j ( C )W 40 L ac iFD "IU Z W Q x 14 jw w 9L~~~ I ( -G AZZ" j 0...00 0 0 0J 0- 3- a& 0 ~~ Cc Cc Cc w-l- Cc- 1. 1 09 ac1’ 1’- 00 ac - aF - 0n I I I l))0 In 01 41 CF ’ 0 0 I -II Y . 00 I I I I 44 I I--I IL I (a 4l In...z 0n / I I b 4 < 4I(-0- ( w40 -K - no . . o1 m In oNC)C -4 -41 -4 I Z 0 " w NM N N. z) IjC mU CZt 0 m " I ZU00 r .NI-0MU) E 00) 0ww w I 0 0 xfmL"j

Diagnosis and Management of Trichothecene in the Swine Model

DTIC Science & Technology

1988-09-01

Robison et a]., 1979), unmetabolized T-2 was found in the milk of a pregnant Holstein cow (third trimester) at levels ranging from 1 to 160 ppb during a 15...t ý ; ,o ,2 U- la o% .o0 e , .q7 , 7 X ~ C% %r n - Y 06 L- Ln 0 0 Ot-0Cc en-1O,’ o N a qcT N CN = -M LnLn L Cn N - LA. qT -1 0 ccC1 oO cow 11 ci. - N...34! 1~ 17. l’ý 1! ’ % ON~~. ci LAM~ ON 0ý m,=10 a 0% Ln~ Cc iUlj4" 0000 00000-cm; e 0-VI0-0 .80- cm 0i 9 a 0%-W 0 0 . r 1f 0000 0 Cow %n -4.iwm-O0 -- lw

Carbon and Nitrogen Mineralization in Relation to Soil Particle-Size Fractions after 32 Years of Chemical and Manure Application in a Continuous Maize Cropping System

PubMed Central

Shao, Xingfang; Zhu, Ping; Zhang, Wenju; Xu, Minggang; Murphy, Daniel V.

2016-01-01

Long-term manure application is recognized as an efficient management practice to enhance soil organic carbon (SOC) accumulation and nitrogen (N) mineralization capacity. A field study was established in 1979 to understand the impact of long-term manure and/or chemical fertilizer application on soil fertility in a continuous maize cropping system. Soil samples were collected from field plots in 2012 from 9 fertilization treatments (M0CK, M0N, M0NPK, M30CK, M30N, M30NPK, M60CK, M60N, and M60NPK) where M0, M30, and M60 refer to manure applied at rates of 0, 30, and 60 t ha−1 yr−1, respectively; CK indicates no fertilizer; N and NPK refer to chemical fertilizer in the forms of either N or N plus phosphorus (P) and potassium (K). Soils were separated into three particle-size fractions (2000–250, 250–53, and <53 μm) by dry- and wet-sieving. A laboratory incubation study of these separated particle-size fractions was used to evaluate the effect of long-term manure, in combination with/without chemical fertilization application, on the accumulation and mineralization of SOC and total N in each fraction. Results showed that long-term manure application significantly increased SOC and total N content and enhanced C and N mineralization in the three particle-size fractions. The content of SOC and total N followed the order 2000–250 μm > 250–53μm > 53 μm fraction, whereas the amount of C and N mineralization followed the reverse order. In the <53 μm fraction, the M60NPK treatment significantly increased the amount of C and N mineralized (7.0 and 10.1 times, respectively) compared to the M0CK treatment. Long-term manure application, especially when combined with chemical fertilizers, resulted in increased soil microbial biomass C and N, and a decreased microbial metabolic quotient. Consequently, long-term manure fertilization was beneficial to both soil C and N turnover and microbial activity, and had significant effect on the microbial metabolic quotient. PMID:27031697

Prime Contract Awards by State, County, Contractor and Place. Fiscal Year 1992. (October - September). North Carolina thru Wyoming

DTIC Science & Technology

1993-01-01

w4 w-4< o j.O -)Q j-j u I 4-~z z a2w wmn 0 aj w 0 Wzc~oj < 3 Lwoziw <. " ý- a 0 j00m jc a a a C .x<-1-40 -4 It4 -- -j-4-4-4- -f.-4.- aCaro 4.4 0 n 0...XM.4 0W .-4 -W4J M Q- w AV ( 0 0 0 w. I-- I-D:)>>>>> 33: -Ir3x tx a,0z z -W ~ VVVg- ~ ~ ~ nI D -I C ~ ~ .1 C C C C C ~ r O C C C C~ 0 C - I 4 4 Il0...34 Ma4 -.1.- .4.4ýD ý_ $ I -. 4.4<.40> -.4 m- > <.,4- M -ý. n 4 .. -. 4--I l z 0 77 w C-:3 UjOW.0. I- It rzC ý 0 m aC Cl Wo .-CC tC ( AV In 016 0 0O.3

Interfacial Properties of Germanium Nitride Dielectric Layers on Germanium.

DTIC Science & Technology

1986-09-30

choice or a process for growing Ge N , layers on germa - nium. a number of workers have employed various de. mum. posited layers on germanium. While...N00014-84-K-0459 V6 Office of Naval Research (Mr. Max N . Yoder, Electronic Division) 4: 800 North Quincy Street Arlington, Virginia 22217 Interfacial...z4) 3 Co0 C14 CM- Lfl n X sj E 𔃺 01 N S) Li (m* m n1 Ln m CU OT X)-(, (L 0IX) D/13si E- 1 0n CtZ) 4-4C ~ IN I- I L L0tX Cd) JN N in - Growth of

Software Reliability Estimation under Conditions of Incomplete Information.

DTIC Science & Technology

1979-10-01

6k) 1 I’a 1 aN+6d (k D N ae a a m a m where ae i Jl i-rnm ae Mem 0 i~m and -A.7- I pop ," -, (L 0 a o\\ a a(0 0 a) ( T n +L L0- (k0 B2 e e aL (0 -TA...zLLki2ZLK22 9o 10 LuNTINUL 97 METURN -D.7- I ,u~t(OUTLiNE H.TA(ABPeNA.T#VvRRPJJJ) .5 mEAL*b toA 𔃾 HLAL kAeX~ oHP #RNiAtR7#DPRZ thEAL RO a Ia$GL(hiR) Kb

Telemetry System Data Latency

DTIC Science & Technology

2017-07-13

ec o n d s Data Rate TELEMETRY SYSTEM DATA LATENCY 15 of 31 Document: JT3-AFC-SRPT-17172-0005 Revision...250 So ft w ar e D ec o m L at en cy N T im es G re at er T h an D xD ec o m L at en cy Data Rate TELEMETRY SYSTEM DATA LATENCY 16 of...20.0 30.0 40.0 50.0 60.0 70.0 M ill is ec o n d s Data Rate TELEMETRY SYSTEM DATA LATENCY 17 of 31 Document:

Effects of n-alkanols and a methyl ester on a transient potassium (IA) current in identified neurones from Helix aspersa.

PubMed Central

Winpenny, J P; Elliott, J R; Harper, A A

1992-01-01

1. A two-microelectrode voltage clamp was used to determine the effects of n-butanol, n-hexanol, n-octanol, n-decanol and methyl hexanoate on a transient potassium (IA) current in identified Helix aspersa neurones. Experiments were carried out at a temperature of 10-12 degrees C. 2. Each n-alkanol reversibly reduced the amplitude of the IA current. Logarithmic dose-response curves for the current reduction by each homologue were sigmoidal and had slope factors of around four. The concentrations required to reduce the peak (with time) current at -30 mV by 50% (ED50 +/- fitted standard error) were: 57 +/- 5 mM (n-butanol); 2.0 +/- 0.1 mM (n-hexanol); 0.28 +/- 0.02 mM (n-octanol) and 0.016 +/- 0.001 mM (n-decanol). Methyl hexanoate also reduced the current amplitude, with an ED50 of 1-2 mM. The Helix IA current thus showed a similar sensitivity to n-alkanols to that of squid and rat sodium currents but was rather more sensitive than the squid delayed rectifier potassium current. 3. The n-alkanol ED50 concentrations were used to calculate a standard free energy per methylene group for adsorption to a site of action in the cell of -3.1 +/- 0.2 kJ/mol. This suggested a hydrophobic site or sites of action. The regularity of the change in free energy with chain length was maintained up to, and including, n-decanol. This implied that the site(s) could accommodate a ten-carbon chain as readily as an eight-carbon chain. 4. The voltage dependencies of IA current activation and steady-state inactivation were not consistently altered by treatment with n-alkanols at concentrations around or above their current suppression ED50 concentrations. 5. The kinetics of current activation and inactivation were affected, particularly by lower chain length compounds. At 60 mM n-butanol reduced the time constant for development of inactivation of open channels (tau b) by 56%, while 0.016 mM n-decanol produced only a 13% reduction. n-Butanol (60 mM) also caused a substantial (76%) reduction in the time constant for development of inactivation in channels which were presumed to be closed. The effects of n-alkanols on the current time-to-peak (tc) were complex, showing both increases and decreases, but these actions also declined with chain length. Methyl hexanoate (1 mM) reduced tau b by around 30% and tc by around 20%. 6. n-Alkanols have now been shown to inhibit a number of voltage-gated ion conductances.(ABSTRACT TRUNCATED AT 400 WORDS) PMID:1293276

Trinity River Bottom Sediment Reconnaissance Study. Phase I. Plan of Work.

DTIC Science & Technology

1976-11-30

CLC AR MAX -A - I C?- 0 0 In~ ~ ~ LO I n nI opC , £. Cc %n.O t 0 3.r 0 1.C) 41C C7M og 0 0 m IIV L. L. 41 04 91- In L-) =4 (D c~ 00 mS %0 % .4...digestion; causes hypertension and cardi,-vascular problems; acr>r,lates in the kidney and liver . Standards for Cadrmium in Water EPA (1972, 1973b, 1975...total chromium. (see Appendix L for detailed procedures.) Copper, Cu: Is essential in trace amounds; in large concentrations may cause liver damage and

Deep-level traps in lightly Si-doped n-GaN on free-standing m-oriented GaN substrates

NASA Astrophysics Data System (ADS)

Yamada, H.; Chonan, H.; Takahashi, T.; Yamada, T.; Shimizu, M.

2018-04-01

In this study, we investigated the deep-level traps in Si-doped GaN epitaxial layers by metal-organic chemical vapor deposition on c-oriented and m-oriented free-standing GaN substrates. The c-oriented and m-oriented epitaxial layers, grown at a temperature of 1000 °C and V/III ratio of 1000, contained carbon atomic concentrations of 1.7×1016 and 4.0×1015 cm-3, respectively. A hole trap was observed at about 0.89 eV above the valence band maximum by minority carrier transient spectroscopy. The trap concentrations in the c-oriented and m-oriented GaN epitaxial layers were consistent with the carbon atomic concentrations from secondary ion mass spectroscopy and the yellow luminescence intensity at 2.21 eV from photoluminescence. The trap concentrations in the m-oriented GaN epitaxial layers were lower than those in the c-oriented GaN. Two electron traps, 0.24 and 0.61 eV below the conduction band (EC) minimum, were observed in the c-oriented GaN epitaxial layer. In contrast, the m-oriented GaN epitaxial layer was free from the electron trap at EC - 0.24 eV, and the trap concentration at EC - 0.61 eV in the m-oriented GaN epitaxial layer was lower than that in the c-oriented GaN epitaxial layer. The m-oriented GaN epitaxial layer exhibited fewer hole and electron traps compared to the c-oriented GaN epitaxial layers.

Comparative Analysis of the Usefulness of the GlideScope®, Macintosh, and McCoy Laryngoscopes for Endotracheal Intubation in Patients with Obesity: A Randomized, Clinical Trial

PubMed Central

Akbarzadeh, Seyed Reza; Taghavi Gillani, Maryar; Tabari, Masoumeh; Morovatdar, Negar

2017-01-01

Background Difficult intubation is dangerous and sometimes fatal, especially in patients with obesity. In difficult intubation cases the best device should be applied to decrease the risk of complications. The current study aimed at comparing laryngoscopes, Macintosh, McCoy, GlideScope® and devices for intubation purposes. Methods A total of 102 patients with obesity and ASA (American society of anesthesiologists) class I or II, and body mass index (BMI) of > 30 kg/m2 were selected. After obtaining the informed consent, the patients were divided into 3 groups based on the 3 laryngoscope types. Preoperative airway assessment including the Mallampati score, thyromental distance (TMD), and neck circumference was performed and all the patients were anesthetized based on the same protocol. Subsequently, all of the patients were intubated using a Macintosh, McCoy, or GlideScope® laryngoscope. Laryngoscopy time, Cormack-Lehane score (1 - 4), and the percentage of glottic opening (POGO; 1 - 100) were evaluated. Data were analyzed using SPSS version 16, and results were considered statistically significant at P ≤ 0.05. Results There was no significant difference between demographic characteristics and preoperative airway evaluations. The shortest and longest laryngoscopy time were obtained in the GlideScope® and McCoy laryngoscope groups, respectively (P = 0.001). The highest Cormack-Lehane score was obtained using the GlideScope® method (P = 0.04). The POGO was higher and, therefore, more appropriate in the McCoy laryngoscope group (P = 0.009). A direct relationship was observed between neck circumference (P = 0.008), BMI (P = 0.023), Mallampati score (P = 0.000), and laryngoscopy. Conclusions In the current study, the shortest and longest intubation time in patients with obesity was observed in the GlideScope® and the McCoy laryngoscope groups, respectively. Moreover, the direct relationships of BMI and neck circumference with laryngoscopy time were observed in all 3 groups. These results suggested using GlideScope® in patients with high BMI to reduce laryngoscopy time. PMID:29696123

Lead Barium Potassium Sodium Niobate Ceramics for Piezoelectric Applications

NASA Astrophysics Data System (ADS)

Sambasiva Rao, K.; Vallisnath, N.; Prasad, T. N. V. K. V.; Ch. Varada Rajulu, K.; Tilak, B.; Lee, Joon Hyung

This paper reports a systematic study of tungsten bronze morphotropic phase boundary (MPB) system Pb2-2X-3Y/2Ba2xREyK1-xNaxNb5O15, where, x = 0.20, 0.25, 0.30, RE = Pr and Bi and y = 0.05 and their structure, microstructure, hysteresis, dielectric, piezoelectric, and Pyroelectric properties. Enhanced piezoelectric constants kp, kt, k31, d31, d33, g31, g33, S11 E as 30.8%, 47.6%, 18.9%, 57 × 10-12 C/N, 159 × 10-12 C/N, 6.89 × 10-3 mV/N, 19.23 × 10-3 mV/N, and 13.88 × 10-12 m2/N respectively are observed in the composition for which y = 0, and x = 0.30, which is above MPB. Also, a change in thickness, 0.0159 μm has been developed for a thickness of the sample 1.2 mm, d33 = 159 × 10-12 C/N and for an applied voltage of 100 V. The same material produces a length extension, 0.0475 μm for d31 = 57 × 10-12 C/N, l = 10 mm, t = 1.2 mm, for an applied voltage of 100 V. Thus the material may be useful for a piezoelectric transducer. Enhanced piezoelectric coefficients, d31 = 96 × 10-12 C/N and g33 = 12.95 × 10-3 mV/N are also observed in the composition for which RE = Pr and x = 0.25.

Mallampati test as a predictor of laryngoscopic view.

PubMed

Adamus, Milan; Fritscherova, Sarka; Hrabalek, Lumir; Gabrhelik, Tomas; Zapletalova, Jana; Janout, Vladimir

2010-12-01

To determine the accuracy of the modified Mallampati test for predicting difficult tracheal intubation. A cross-sectional, clinical, observational, non-blinded study. A quality analysis of anesthetic care. Operating theatres and department of anesthesiology in a university hospital. Following the local ethics committee approval and patients' informed consent to anesthesia, all adult patients (> 18 yrs) presenting for any type of non-emergency surgical procedures under general anesthesia requiring endotracheal intubation were enrolled. Prior to anesthesia, Samsoon and Young's modification of the Mallampati test (modified Mallampati test) was performed. Following induction, the anesthesiologist described the laryngoscopic view using the Cormack-Lehane scale. Classes 3 or 4 of the modified Mallampati test were considered a predictor of difficult intubation. Grades 3 or 4 of the Cormack-Lehane classification of the laryngoscopic view were defined as impaired glottic exposure. The sensitivity, specificity, positive and negative predictive value, relative risk, likelihood ratio and accuracy of the modified Mallampati test were calculated on 2x2 contingency tables. Of the total 1,518 patients enrolled, 48 had difficult intubation (3.2%). We failed to detect as many as 35.4% patients in whom glottis exposure during direct laryngoscopy was inadequate (sensitivity 0.646). Compared to the original article by Mallampati, we found lower specificity (0.824 vs. 0.995), lower positive predictive value (0.107 vs. 0.933), higher negative predictive value (0.986 vs. 0.928), lower likelihood ratio (3.68 vs. 91.0) and accuracy (0.819 vs. 0.929). When used as a single examination, the modified Mallampati test is of limited value in predicting difficult intubation.

Prime Contract Awards by State or Country, Place and Contractor. Part 8 (Newport Army Ammunition Plant, Indiana - Dorsey, Maryland), FY1991

DTIC Science & Technology

1991-01-01

8217(0INC 347 0)( 4M Www (A n0 c) ()O 1a- 4AmNIl >. .44 4 N NNWW inC H (-440 44zz OZ2 ZZ czz2Z c2 cz2Z c2 cz2zzzz CZ 1. :(0 CO 102222zz * fuzz* 402222...00400 4 0 0 0 0C . D r- 0 0D 4 n1c0 IL if 0D I 40071 It 00 co g 000000 00 0 4 000 M0rm0MMC 000 04< C 00 C9ofII  If 00 ( nOWO in000000000 0(d 000

Yellow Sea Mine Hunting Using the Navy’s CASS/GRAB Model

DTIC Science & Technology

2001-05-01

f15fe eeapoiaey5 ad o h otso 04 t.Y .a. L ion leo 210. 210 £igure 14. Februarv GDEM 4 hr a. Rock Botton at 37.5 N 123.0 E and a Source Depth= 25 .a...SinlLcsscnor 2zs47 * .... ... lt- . . .... ° 1 . ,, . ....... . . ........ lot ýto0 a. Figre2I FbruryGDM ~r G’ae•Botoma•.•..N 230Eand a Source Dpt 2-5 ft. a...1m • GDEM for a G ave4 B0to a 38 0.350Nt;J0 n So7 re Det,0 125ft a.RyTae0n3?Sga Ecs odm M30 aw -, .3 m- a n.03 3.b. 0.00~~~~ co?50.007 S• •r, • • •, • l

Computer Simulation of Maximum Likelihood Output for Standard Langlie Test, (N=12)

DTIC Science & Technology

1977-12-01

Ca co 2 N1M> UID12 D 0 c r i IN %CM mIm4i 4Z 44, , 744 3L x 0󈧎 0󈨞𔃺𔃺’ 0’ (’a𔃺’’ 7’ , 0’ 0’ ZI r- co 0 0’ co0 Y,’ 00 o, a a0𔃺, ,l , o 0’ 0

All Prime Contract Awards by State or Country, Place, and Contractor. Part 10 (Croom, Maryland-Mendon, Mass)

DTIC Science & Technology

1990-01-01

A -IfCJ A ACI 11 LO n (O ? )-t ((D In ((D D-0- n InW ItJ0- W MJWW W .1 ..I<(-4 it I I 1-UCI 41) 0 (04 >1 :: o c" C c14 A CA ACCA C (,j AOCANAN" C CA C...7 )0470 C )) )4))M )( DD000 )0 )0 M0) 0) M0( F8 -00 0 0 8-481I8IM(0.4 it " 0) () r-000000000000000000000000000000000 00 0 ) ) -w I(0-4 it 1A

Mean Conditions and Turbulence Statistics at Vandenberg AFB, California,

DTIC Science & Technology

1984-11-01

2NN M N NN ’CN N NN N4 I’~tJN NN NIJN I pIi JN’ W’N NCJ’ ViNNCJ m I’N’(I N’N CJ N N N C’ 0 ’o CD22 REPRODUCEDU AT CG0VFRr4?A.FJ1 uvrF 11.4 PiJ0t’ N

On the output factor measurements of the CyberKnife iris collimator small fields: Experimental determination of the k{sub Q{sub c{sub l{sub i{sub n,Q{sub m{sub s{sub r}{sup f{sub c}{sub l}{sub i}{sub n},f{sub m}{sub s}{sub r}}}}}}}}} correction factors for microchamber and diode detectors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pantelis, E.; Moutsatsos, A.; Zourari, K.

Purpose: To measure the output factors (OFs) of the small fields formed by the variable aperture collimator system (iris) of a CyberKnife (CK) robotic radiosurgery system, and determine the k{sub Q{sub c{sub l{sub i{sub n,Q{sub m{sub s{sub r}{sup f{sub c}{sub l}{sub i}{sub n},f{sub m}{sub s}{sub r}}}}}}}}} correction factors for a microchamber and four diode detectors. Methods: OF measurements were performed using a PTW PinPoint 31014 microchamber, four diode detectors (PTW-60017, -60012, -60008, and the SunNuclear EDGE detector), TLD-100 microcubes, alanine dosimeters, EBT films, and polymer gels for the 5 mm, 7.5 mm, 10 mm, 12.5 mm, and 15 mm irismore » collimators at 650 mm, 800 mm, and 1000 mm source to detector distance (SDD). The alanine OF measurements were corrected for volume averaging effects using the 3D dose distributions registered in polymer gel dosimeters. k{sub Q{sub c{sub l{sub i{sub n,Q{sub m{sub s{sub r}{sup f{sub c}{sub l}{sub i}{sub n},f{sub m}{sub s}{sub r}}}}}}}}} correction factors for the PinPoint microchamber and the diode dosimeters were calculated through comparison against corresponding polymer gel, EBT, alanine, and TLD results. Results: Experimental OF results are presented for the array of dosimetric systems used. The PinPoint microchamber was found to underestimate small field OFs, and a k{sub Q{sub c{sub l{sub i{sub n,Q{sub m{sub s{sub r}{sup f{sub c}{sub l}{sub i}{sub n},f{sub m}{sub s}{sub r}}}}}}}}} correction factor ranging from 1.127 {+-} 0.022 (for the 5 mm iris collimator) to 1.004 {+-} 0.010 (for the 15 mm iris collimator) was determined at the reference SDD of 800 mm. The PinPoint k{sub Q{sub c{sub l{sub i{sub n,Q{sub m{sub s{sub r}{sup f{sub c}{sub l}{sub i}{sub n},f{sub m}{sub s}{sub r}}}}}}}}} correction factor was also found to increase with decreasing SDD; k{sub Q{sub c{sub l{sub i{sub n,Q{sub m{sub s{sub r}{sup f{sub c}{sub l}{sub i}{sub n},f{sub m}{sub s}{sub r}}}}}}}}} values equal to 1.220 {+-} 0.028 and 1.077 {+-} 0.016 were obtained for the 5 mm iris collimator at 650 mm and 1000 mm SDD, respectively. On the contrary, diode detectors were found to overestimate small field OFs and a correction factor equal to 0.973 {+-} 0.006, 0.954 {+-} 0.006, 0.937 {+-} 0.007, and 0.964 {+-} 0.006 was measured for the PTW-60017, -60012, -60008 and the EDGE diode detectors, respectively, for the 5 mm iris collimator at 800 mm SDD. The corresponding correction factors for the 15 mm iris collimator were found equal to 0.997 {+-} 0.010, 0.994 {+-} 0.009, 0.988 {+-} 0.010, and 0.986 {+-} 0.010, respectively. No correlation of the diode k{sub Q{sub c{sub l{sub i{sub n,Q{sub m{sub s{sub r}{sup f{sub c}{sub l}{sub i}{sub n},f{sub m}{sub s}{sub r}}}}}}}}} correction factors with SDD was observed. Conclusions: This work demonstrates an experimental procedure for the determination of the k{sub Q{sub c{sub l{sub i{sub n,Q{sub m{sub s{sub r}{sup f{sub c}{sub l}{sub i}{sub n},f{sub m}{sub s}{sub r}}}}}}}}} correction factors required to obtain small field OF results of increased accuracy.« less

All Prime Contract Awards by State or Country, Place, and Contractor, FY 88. Part 6. (Alachua, Florida-Woodstock, Georgia).

DTIC Science & Technology

1988-01-01

9W P.- 1 1 (000 1-4-4 1 1-44-- 4. -4 -4 -4 --- 4 4-4-4 -4 ~-4--4 -4-4 "-4 N-4,𔃾 4-4 -4 F- I MOLA (0 I IWNNN m WNCNiC.JNC’J .. NൌN" m"N C𔃾 I(OLA( W 4...4 -4 -41-4 -4-4 -4 c -4 -4 c - A- 4- 4- l’- I MOLA (0 I JN NN N NN N 0N N NNl’,N MN 0N MN"NNN it IC00In(0 -4. -1-4-4-4_4--4-4 -4 ~~~-4 ’-4-4-4 -4 .l...toNNNNNCJ C1 MU (N C 0 0 (0 4N 0 0 I MOLA (0 1-4 -4 -4 -4 -4-4 -4 -4 -4-4-4 -4 4 -4--1 -4 -4-4 14 4 -4444- --fI4--4 o I (00A4 I -00000 ’-0 -000000000000 ’-0

A Comparison between the Rhesus Monkey and the Human on the Effect of Atropine on the Electroencephalogram. Volume 2. Preliminary Statistical Analysis of Spectral EEG Waveforms in Rhesus Monkeys Exposed to Atropine.

DTIC Science & Technology

1994-11-01

20 i 1 19. ABSTRACT (Continue on reverze if necenay and ident•f by block numbierj See other side. • DTIC • ~S EL ECTE . JAN 0 4 1994 ") ~F 20...82171LfOVfO U~) iv0 m 0O El .hC N- HN.- Hr4r- C.N w 000000 000000 000000 000000 000000 1W I.ŕ 00 -r -r .O D ,a o r oL)ria 4-) 0) .I. . . . . . .9 I W) 0...mmmmHmDm HH L’mommLmm mNm mNNmm LOmm)N.mmmm HOWHMMWWH0)N000 ODr4O 0 NOr wr- w w w w. rNMNOVNO V~ El . H H - H v H H -H AA Hr0WHHHNV M ONN~OOH OM UNN

Treatment outcome and prognostic factor of CO2 laser cordectomy for early glottic cancer

NASA Astrophysics Data System (ADS)

Chung, Phil-Sang; Lee, Sang Joon

2012-02-01

Objectives: Laser cordectomy is very popular nowadays and become one of the treatments of choice for early glottis carcinoma. Transoral laser microsurgery has many advantages comparing conventional open surgery or radiation therapy. In this study, we examined the oncologic results of laser cordectomy for early glottic cancer and analyzed the prognostic impact on the survival of the several tumor-related and treatment-related factors. Methods: Patients who were diagnosed as early glottic squamous cell carcinoma, treated by laser cordectomy with curative intent were analyzed. Patients with preivous radiation therapy were included. From June 1988 to March 2005, 202 patients from five hospitals were analyzed (174 T1, 28 T2). Results: Five-year overall survival and disease-free survival were 98.4% and 84.9%. Twenty two patients developed local recurrence. Total laryngectomy was done in 6 patients and laryngeal preservation rate was 97%. Recurrence was higher in the patients with anterior commissure involvement (9/39) than without anterior commissure involvement (13/163). Recurrence was higher in T1b (4/15) than T1a (13/159). Previous radiation was also highly related to the recurrence (7/20 vs 15/182). Twenty patients with local recurrence after radiation therapy were treated by salvage laser cordectomy. Of them, 7 patients developed local recurrence and 5 year disease-free survival was 57%. Complication was rare with one case of hemorrhage. Tracheotomy was not necessary in all patients. Conclusions: Laser cordectomy for early glottic carcinoma showed high survival, laryngeal preservation rate and low complication rate. The prognostic factors were anterior commissure involvement, both vocal fold involvement and previous radiotherapy.

Computational fluid dynamics in the assessment of patients' postoperative status after glottis-widening surgery.

PubMed

Marków, Magdalena; Janecki, Daniel; Orecka, Bogusława; Misiołek, Maciej; Warmuziński, Krzysztof

2017-09-01

Computational fluid dynamics (CFD), a rapidly developing instrument with a number of practical applications, allows calculation and visualization of the changing parameters of airflow in the upper respiratory tract. The aim of this study was to demonstrate the advantages of CFD as an instrument for noninvasive tests of the larynx in patients who had undergone surgical treatment due to bilateral vocal fold paralysis. Surface measurements of the glottic space were made during maximum adduction of the vocal folds. Additionally, the following spirometric parameters were determined: forced vital capacity (FVC), forced expiratory volume in the first second (FEV1), and peak expiratory flow (PEF) rate. Based on the measurements, commercial mesh generation software was used to develop a geometrical model of the glottic space. The computations were carried out using a general purpose CFD code. The analysis included patients who were surgically treated for BVFP in the authors' department between 1999 and 2012. The study group consisted of 22 women (91.67%) and 2 men (8.33%). It was observed that the pressure drop calculated for free breathing depends on the area of the glottis and is independent of its shape. Importantly, for areas below approx. 40 mm2, a sudden rise occurred in the resistance to flow; for the smallest glottic areas studied, the pressure drop was almost 6 times higher than for an area of 40 mm2. Consequently, in cases of areas below 40 mm2 even minor enlargement of the glottic opening can lead to a marked improvement in breathing comfort. Computational fluid dynamics is a useful method for calculating and visualizing the changing parameters of airflow in the upper respiratory tract.

The Use of Cryotherapy for Papilloma and Early Laryngeal Cancers: Long-term Results.

PubMed

Benninger, Michael S; Derakhshan, Adeeb; Milstein, Claudio F

2015-07-01

Retrospective chart review. To determine the efficacy of adjuvant cryotherapy in the treatment of early glottic cancer and laryngeal papillomatosis. The use of cryotherapy in conjunction with traditional modalities has recently been proposed to improve voice outcomes in patients with early laryngeal cancer as compared to pretreatment conditions. This study investigates its utility in improving oncological outcomes and decreasing recurrences of laryngeal papillomatosis. Patients with either early glottic cancer or laryngeal papillomatosis that received cryotherapy as part of their surgical regimen were investigated. All patients were seen at a large tertiary care center within a 10-year window. Demographic data were collected and all postoperative notes were reviewed. Recurrences of the laryngeal cancer were noted, as was the duration of time between successive papillomatosis operations. The charts of 54 glottic cancer and 29 papillomatosis patients that received cryotherapy were reviewed. One patient from the papillomatosis cohort was excluded from statistical analysis due to lack of follow-up. Overall, 16 (30%) of the laryngeal cancer patient experienced a malignant recurrence. The overall 5-year survival of these patients was 98% and the 5-year disease-free survival was 74%. The use of adjuvant cryotherapy in the treatment of laryngeal papillomatosis extended the duration of time between surgeries by an average of 79 days (P=.23). The use of adjuvant cryotherapy in the treatment of early glottic cancer does not improve the rate of carcinoma recurrences. Additionally, cryotherapy does not result in a statistically significant increase in the duration of disease-free period for laryngeal papillomatosis patients, although the observed increase may be clinically important. © The Author(s) 2015.

VHDL Modeling of PRC-70 Radio ASICs for Reverse Engineering

DTIC Science & Technology

1994-08-01

VDVDDvm TZMP ATRWa-T IMPML4MM) pact mWu (1155_0, 1184-0, 1199.0); somork map (DE.AY-> 1uw FANC ~m3 VDDO.VDD. port mwap (M19.0 191 10.. fl0...)*, 194: mnv...IWMDEAY1> fl, VDD-VDD, M eMMUR1T 1F1O𔃽ATU3) part map(1139) ,RCIR...9Qj14Q)); gen ricmap (DELAYm.o I r, 1IANOUYF.o1, VD~mVDD, pact map (1140YNJ136YW9Y...8217URE-TEMPBRATURE) port map (N945,N2467); 11341: inv generic map (DELAY->1 as, FANC )UT->1, VDD->VDD, TEMPERATURE->TEMPMRThRB) pod map (N24M h25 1); 11344

Comparative, general pharmacology of SDZ NKT 343, a novel, selective NK1 receptor antagonist

PubMed Central

Walpole, C S J; Brown, M C S; James, I F; Campbell, E A; McIntyre, P; Docherty, R; Ko, S; Hedley, L; Ewan, S; Buchheit, K-H; Urban, L A

1998-01-01

The in vitro and in vivo pharmacology of SDZ NKT 343 (2-nitrophenyl-carbamoyl-(S)-prolyl-(S)-3-(2-naphthyl)alanyl-N-benzyl-N-methylamide), a novel tachykinin NK1 receptor antagonist was investigated.SDZ NKT 343 inhibited [3H]-substance P binding to the human NK1 receptor in transfected Cos-7 cell membranes (IC50=0.62±0.11 nM). In comparison, in the same assay Ki values for FK888, CP 99,994, SR 140,333 and RPR 100,893 were 2.13±0.04 nM, 0.96±0.20 nM, 0.15±0.06 nM and 1.77±0.41 nM, respectively. SDZ NKT 343 showed a markedly lower affinity at rat NK1 receptors in whole forebrain membranes (IC50=451±139 nM).SDZ NKT 343 caused an increase in EC50 as well as reduction in the number of binding sites (Bmax) determined for [3H]-substance P, suggesting a non-competitive interaction at the human NK1 receptor. SDZ NKT 343 also caused a reduction in the maximum elevation of [Ca2+]i evoked by substance P (SP) in human U373MG cells and depressed the maximum [Sar9]SP sulphone-induced contraction of the guinea-pig isolated ileum. The antagonism of SP effects on U373MG cells by SDZ NKT 343 was reversible.SDZ NKT 343 showed weak affinity to human NK2 and NK3 receptors in transfected Cos-7 cells (Ki of 0.52±0.04 μM and 3.4±1.2 μM, respectively). SDZ NKT 343 was inactive in a broad array of binding assays including the bradykinin B2 receptor the histamine H1 receptor, opiate receptors and adrenoceptors. SDZ NKT 343 only weakly inhibited the voltage-activated Ca2+ and Na+currents in guinea-pig dorsal root ganglion neurones. The enantiomer of SDZ NKT 343, (R,R)-SDZ NKT 343 was about 1000 times less active at human NK1 receptors expressed in Cos-7 cell membranes.Contractions of the guinea-pig ileum by [Sar9]SP sulphone were inhibited by SDZ NKT 343 in a concentration-dependent manner, with an IC50=1.60±0.94 nM, while the enantiomer (R,R)-SDZ NKT 343 was 100 times less active (IC50=162±26 nM). In comparison, in the same assay IC50 values for other NK1 receptor antagonists CP 99,994, SR 140,333, RPR 100,893 and FK 888 were 2.90±07 nM, 0.14±0.02 nM, 11.4±2.9 nM and 2.4±0.83 nM, respectively.In anaesthetized guinea-pigs i.v. administered SDZ NKT 343 antagonized [Sar9]SP sulphone-evoked bronchoconstriction (70% reduction at 0.4 mg kg−1, i.v.). Basal airway resistance, mean arterial blood pressure and heart rate were not affected.In conclusion, SDZ NKT 343 is a highly selective NK1 receptor antagonist with high potency at the human and guinea-pig receptors. SDZ NKT 343 may be used as a potential novel therapeutic agent in human diseases where NK1 receptor hyperfunction is involved. PMID:9630347

Installation Restoration Program. Phase 2. Confirmation/Quantification. Stage 1. Air Force Plant 6, Cobb County, Georgia. Volume 2.

DTIC Science & Technology

1986-08-09

aquifer analysis, and sampling of ground water monitor wells to determine effectiveness of wastewater treatment process. Ida- Con Corporation...The Pro ect )A Spervisor i dc :7ri J, I, ontrollin hvde co n ... nsr 44 a Fie Ld note books, Iogsheets , be nch sheets, t rac in.r r-l, and report...NON .ocp 4a 0 .0... .. - a o 00--.--- ( N NN N .4N .)mm o m mM 3 2 4.2 3 3 3 3 33 3 3 3 m w r3 GmO 23 U, 3 33 3 2 3 3 3 30O13 CŘ oa nL nV) 0U n ( A 0L

Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, FY 88. Part 7. (Eastport International-Flint Electric Membership Corp.)

DTIC Science & Technology

1988-01-01

0 00--400000000000000-40000000000 0 q’mwavI m 00 00000(00000000000000000(0O ANIWOV I (00400550 1 0 0 5 0 t~sWOqU I NNNM C𔃻".)O)a s...4 N J 5 ’ 5 M - -4 1100-4 1 040N ,-4 N4 N 44444444-l444444444---------- -4 1 0 -40 1 <  <<ɜ< 4c 190-40 1 -4 -4- -44-4 -4 -4 -4 es!-4 -4-4 -4...009’.. I NNIN-4 NS N (7N4-4 NNN.- Cl- INN-4 "-4-4 -4 .J4 " NN NNNNNN4NC 0 N 󈧄o( 0 I >->->-"- . 5 .’ . . ....... D.

Alpha List of Prime Contract Awards. Oct 91 - Sep 92. FY 92. (Johnson Regina A - Mac-Bestos Inc).

DTIC Science & Technology

1993-01-01

om ot -1 ý- ý- -1 (𔃾 -<<< W tl- (0 " (14 00 - 3: 3 3:ý, 3:x:ý: 3 0 1 <f Q (1) of 103M 4 (.) I . I Li 100(-) 1 L) L) L) (.) L) 0 0 (-) It t < 0 N to...laZZ t 10000 HI*. .,.4 1 * L. III ~ ~ i H 10- mI r0It-0H-I-I. rH --r-f- - 000 Ivc’) P. COO** 0 O--00* l~. HI H 000 it c (00 000-40 c -)O L01-0( 01400a...L. Q00) II, N 0000 If mmmM MIX)DDC 103M moo 10010101010101010110101011Comm a -4 1 or-. If NC"""" A.."NC U1 a01 NZ-J( JC’ (N C’ II L u) of N1 1 0 aO

Physical Oceanography Report. Helicopter-Based STD Data from MIZEX 83 (Marginal Ice Zone Experiment).

DTIC Science & Technology

1984-09-01

platform /sonde-cradle support system was developed at Lamont to specifically conform to the passenger compartment ofI Unfortunately, the 202 underwater...NN o Ito~,O rd-toc,-t CD 0 000-0 N-10 6, )-0ooUo06oOo owo V 000000 WIX ; OAO. N AIN to.6uIND- 6ro"~ooo’o NK 6-ooW m 0 0 Lai 0 .NN NN I 0 Z M’%W~0~N