Sample records for nagi loomisest rgib

  1. Matching the Nagy-Soper parton shower at next-to-leading order

    NASA Astrophysics Data System (ADS)

    Czakon, M.; Hartanto, H. B.; Kraus, M.; Worek, M.

    2015-06-01

    We present an Mc@Nlo-like matching of next-to-leading order QCD calculations with the Nagy-Soper parton shower. An implementation of the algorithm within the Helac-Dipoles Monte Carlo generator is used to address the uncertainties and ambiguities of the matching scheme. First results obtained using the Nagy-Soper parton shower implementation in Deductor in conjunction with the Helac-Nlo framework are given for the process at the LHC with TeV. Effects of resummation are discussed for various observables.

  2. Unraveling the etiology of North American grapevine yellows (NAGY): multilocus genotyping and structural analysis of secY proteins distinguish NAGYIII phytoplasma strains from strains causing X-disease

    USDA-ARS?s Scientific Manuscript database

    North American grapevine yellows (NAGY) disease has sometimes been ascribed to infection of Vitis vinifera L. by X-disease phytoplasma, but the accuracy of this attribution has remained open to question. In the present study of NAGY etiology, the disease was discovered in Maryland, Pennsylvania, Oh...

  3. Complete Nagy-Soper subtraction for next-to-leading order calculations in QCD

    NASA Astrophysics Data System (ADS)

    Bevilacqua, G.; Czakon, M.; Kubocz, M.; Worek, M.

    2013-10-01

    We extend the Helac-Dipoles package with the implementation of a new subtraction formalism, first introduced by Nagy and Soper in the formulation of an improved parton shower. We discuss a systematic, semi-numerical approach for the evaluation of the integrated subtraction terms for both massless and massive partons, which provides the missing ingredient for a complete implementation. In consequence, the new scheme can now be used as part of a complete NLO QCD calculation for processes with arbitrary parton masses and multiplicities. We assess its overall performance through a detailed comparison with results based on Catani-Seymour subtraction. The importance of random polarization and color sampling of the external partons is also examined.

  4. Toward Overcoming the Local Minimum Trap in MFBD

    DTIC Science & Technology

    2015-07-14

    the first two years of this grant: • A. Cornelio, E. Loli -Piccolomini, and J. G. Nagy. Constrained Variable Projection Method for Blind Deconvolution...Cornelio, E. Loli -Piccolomini, and J. G. Nagy. Constrained Numerical Optimization Meth- ods for Blind Deconvolution, Numerical Algorithms, volume 65, issue 1...Publications (published) during reporting period: A. Cornelio, E. Loli Piccolomini, and J. G. Nagy. Constrained Variable Projection Method for Blind

  5. Examining Incidental Vocabulary Acquisition by Person-and Item-Level Factors in Secondary Students

    ERIC Educational Resources Information Center

    Cooper, Jennifer LeeAnn

    2016-01-01

    Vocabulary knowledge is central to the process of reading comprehension (Cromely & Azevedo, 2007; Stahl & Nagy, 2005; Stanovich, 1986). The majority of our vocabulary knowledge is postulated to come from the process of incidental vocabulary acquisition (IVA) while reading (Nagy & Anderson, 1984). Prior studies have estimated an average…

  6. Nagy-Soper Subtraction: a Review

    NASA Astrophysics Data System (ADS)

    Robens, Tania

    2013-07-01

    In this review, we present a review on an alternative NLO subtraction scheme, based on the splitting kernels of an improved parton shower that promises to facilitate the inclusion of higher-order corrections into Monte Carlo event generators. We give expressions for the scheme for massless emitters, and point to work on the extension for massive cases. As an example, we show results for the C parameter of the process e+e-→3 jets at NLO which have recently been published as a verification of this scheme. We equally provide analytic expressions for integrated counterterms that have not been presented in previous work, and comment on the possibility of analytic approximations for the remaining numerical integrals.

  7. On the number of entangled qubits in quantum wireless sensor networks

    NASA Astrophysics Data System (ADS)

    Mohapatra, Amit Kumar; Balakrishnan, S.

    2016-08-01

    Wireless sensor networks (WSNs) can take the advantages by utilizing the security schemes based on the concepts of quantum computation and cryptography. However, quantum wireless sensor networks (QWSNs) are shown to have many practical constraints. One of the constraints is the number of entangled qubits which is very high in the quantum security scheme proposed by [Nagy et al., Nat. Comput. 9 (2010) 819]. In this work, we propose a modification of the security scheme introduced by Nagy et al. and hence the reduction in the number of entangled qubits is shown. Further, the modified scheme can overcome some of the constraints in the QWSNs.

  8. METEORITIC HYDROCARBONS AND EXTRATERRESTRIAL LIFE

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Anders, E.

    1962-08-29

    A critical discussion is given of the comparison by Nagy Meinschein, and Hennessy of the mass spectra of the hydrocarbons from the distillate of the Orgueil meteorite with the mass spectra of two biogenic materials, butter and sediments. The conclusion of Nagy et al. that biogenic processes occur in the universe beyond the earth, is crfticized on the basis of the following facts: the mass spectra are only superficially similar; contamination is a serious problem at these low concentrations; the meteorite is very porous and hence will absorb considerable amounts of atmospheric constituents; the peak heights are not truly representativemore » of specific compounds; the meteorite contains free suifur, which would dehydrogenate hydrocarbons on heating; etc. (D.L.C.)« less

  9. Nagy-Soper subtraction scheme for multiparton final states

    NASA Astrophysics Data System (ADS)

    Chung, Cheng-Han; Robens, Tania

    2013-04-01

    In this work, we present the extension of an alternative subtraction scheme for next-to-leading order QCD calculations to the case of an arbitrary number of massless final state partons. The scheme is based on the splitting kernels of an improved parton shower and comes with a reduced number of final state momentum mappings. While a previous publication including the setup of the scheme has been restricted to cases with maximally two massless partons in the final state, we here provide the final state real emission and integrated subtraction terms for processes with any number of massless partons. We apply our scheme to three jet production at lepton colliders at next-to-leading order and present results for the differential C parameter distribution.

  10. On the reported optical activity of amino acids in the Murchison meteorite

    USGS Publications Warehouse

    Bada, J.L.; Cronin, J.R.; Ho, M.-S.; Kvenvolden, K.A.; Lawless, J.G.; Miller, S.L.; Oro, John; Steinberg, S.

    1983-01-01

    In analyses of extracts from the Murchison meteorite (a carbonaceous chondrite), Engel and Nagy1 reported an excess of L-enantiomers for several protein amino acids but found that the non-protein amino acids were racemic. They suggested that the excess of L-isomers might have resulted from an asymmetric synthesis or decomposition. Their results disagree with those obtained previously2-4 and they claim this is due to improved methodology. In fact, their extraction method and analytical procedure (gas chromatography-mass spectrometry, GC-MS) was similar to those used in the original report2 of amino acids in the Murchison meteorite except that they used specific ion monitoring in the GC-MS measurements. We found the results of Engel and Nagy odd in that likely contaminants (the protein amino acids ala, leu, glu, asp and pro) were nonracemic while unlikely contaminants (isovaline and ??-amino-n-butyric acid) were racemic. For example, Engel and Nagy report that the leucine is ???90% L-enantiomer in the water-extracted sample whereas isovaline (??-methyl-??-aminobutyric acid) is racemic. It would be most unusual for an abiotic stereoselective decomposition or synthesis of amino acids to occur with protein amino acids but not with non-protein amino acids. We now show here that the explanation of terrestrial contamination is consistent with their results and is much more probable. ?? 1983 Nature Publishing Group.

  11. DOE Office of Scientific and Technical Information (OSTI.GOV)

    Aiken, George

    This document is the final technical report for a project designed to address fundamental processes controlling the release of mercury from flood plain soils associated with East Fork Poplar Creek, Tennessee near the U.S. Department of Energy Oak Ridge facility. The report summarizes the activities, findings, presentations, and publications resulting from an award to the U.S. Geological that were part of a larger overall effort including Kathy Nagy (University of Illinois, Chicago, Ill) and Joseph Ryan (University of Colorado, Boulder, CO). The specific charge for the U.S.G.S. portion of the study was to provide analytical support for the larger groupmore » effort (Nagy and Ryan), especially with regard to analyses of Hg and dissolved organic matter, and to provide information about the release of mercury from the floodplain soils.« less

  12. Investigation of Means of Mitigating Congestion in Complex, Distributed Network Systems by Optimization Means and Information Theoretic Procedures

    DTIC Science & Technology

    2008-02-01

    Information Theoretic Proceedures Frank Mufalli Rakesh Nagi Jim Llinas Sumita Mishra SUNY at Buffalo— CUBRC 4455 Genessee Street Buffalo...5f. WORK UNIT NUMBER NY 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) SUNY at Buffalo— CUBRC * Paine College ** 4455 Genessee

  13. Evaluating the utility of existing patient-reported outcome scales in novel patient populations with pancreatic cancer, lung cancer, and myeloproliferative neoplasms using medicare current beneficiary survey data.

    PubMed

    Ivanova, Jasmina I; Mytelka, Daniel S; Duh, Mei Sheng; Birnbaum, Howard G; Cummings, Alice Kate; San Roman, Alexandra M; Price, Gregory L; Swindle, Ralph W

    2013-01-01

    While there are validated patient-reported outcomes (PRO) instruments for use in specific cancer populations, no validated general instruments exist for use in conditions common to multiple cancers, such as muscle wasting and consequent physical disability. The Medicare Current Beneficiary Survey (MCBS), a survey in a nationally representative sample of Medicare beneficiaries, includes items from three well known scales with general applicability to cancer patients: Katz activities of daily living (ADL), Rosow-Breslau instrumental ADL (IADL), and a subset of physical performance items from the Nagi scale. This study evaluated properties of the Katz ADL, Rosow-Breslau IADL, and a subset of the Nagi scale in patients with pancreatic cancer, lung cancer, and myeloproliferative neoplasms (MPN) using data from MCBS linked with Medicare claims in order to understand the potential utility of the three scales in these populations; understanding patient-perceived significance was not in scope. The study cohorts included Medicare beneficiaries aged ≥65 years as of 1 January of the year of their first cancer diagnosis with one or more health assessments in a community setting in the MCBS Access to Care data from 1991 to 2009. Beneficiaries had at least two diagnoses in de-identified Medicare claims data linked to the MCBS for one of the following cancers: pancreatic, lung, or MPN. The Katz ADL, Rosow-Breslau IADL, and Nagi scales were calculated to assess physical functioning over time from cancer diagnosis. Psychometric properties for each scale in each cohort were evaluated by testing for internal consistency, test-retest reliability, and responsiveness by comparing differences in mean scale scores over time as cancer progresses, and differences in mean scale scores before and after hospitalization (for lung cancer cohort). The study cohorts included 90 patients with pancreatic cancer, 863 with lung cancer, and 135 with MPN. Among each cancer cohort, the Katz ADL, Rosow

  14. 78 FR 36582 - Agency Information Collection Activities; Proposed Collection; Comments Requested; Extension With...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-18

    ... Richard L. Nagy, Unit Chief, Domestic Strategic Intelligence Unit, Office of Intelligence, Warning, Plans...' estimate of the burden of the proposed collection of information, including the validity of the methodology... number: None. Component: Intelligence Division, Drug Enforcement Administration, U.S. Department of...

  15. Morphological Awareness and Reading in Second and Fifth Grade: Evidence from Hebrew

    ERIC Educational Resources Information Center

    Vaknin-Nusbaum, Vered; Sarid, Miri; Shimron, Joseph

    2016-01-01

    Research suggests that morphological awareness facilitates word decoding, improves lexical knowledge, and helps reading comprehension (Carlisle, 2010; Nagy et al., 2014; Verhoeven & Perfetti, 2011). The present study examined the relationship among morphological awareness, word recognition and reading comprehension in 153 second- and…

  16. The Storybook Number Competencies Intervention: Learning Quantitative Vocabulary and Number Sense through Story Reading

    ERIC Educational Resources Information Center

    Hassinger-Das, Brenna

    2013-01-01

    Without providing effective, evidenced-based instruction during the early elementary years, children who come to school with low initial levels of mathematics and reading skills often continue to fall further behind their peers (Anderson & Nagy, 1992; Hart & Risley, 1995). However, educational interventions show promise for helping…

  17. Measuring the Price of Anarchy via Perspective Optimization of Unmanned Vehicles in ISR Operations

    DTIC Science & Technology

    2012-10-24

    nagi@buffalo.edu Dr. Moises Sudit1,3 sudit@cubrc.org 1 CUBRC , Inc. Buffalo, NY USA 2 Raytheon, Inc. Annapolis Junction, MD USA 3 University at Buffalo...ADDRESS(ES) CUBRC , Inc. Buffalo, NY USA 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING/MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR

  18. Implementation of a Project-Based Concept Mapping Developmental Programme to Facilitate Children's Experiential Reasoning and Comprehension of Relations

    ERIC Educational Resources Information Center

    Habok, Anita

    2015-01-01

    School readiness evaluations are becoming increasingly popular, and their implementation has become compulsory in an increasing number of kindergartens and schools in Hungary. In recent years, Diagnostic System for Evaluating Development (DIFER), developed by Nagy et al. has been used extensively for the diagnostic study of four- to eight-year-old…

  19. Application of the Theory of Wave Propagation through Random Media to Phase and Amplitude Fluctuations of Seismic P-Waves

    DTIC Science & Technology

    1988-10-18

    Minser, D.. Wave propagation us a ramly inbomamnous medium, New York, 1960. J. Acowl. Soc. Am.. 25,922-927,1953. Dashen. R.. Path integrals for...91360 Mr. Roy Burger 1221 Serry Rd. Schenectady, NY 12309 Mr. Edward Giller Dr. Geza Nagy Pacific Seirra Research Corp. U. California, San Diego 1401

  20. Conceptualizations of Vocabulary Knowledge in Second Language Reading

    ERIC Educational Resources Information Center

    Tsai, Aurora

    2017-01-01

    Reading research has recognized the strong relationship between vocabulary and reading comprehension. However, we are still perplexed by the precise nature of how readers access and retrieve word meanings while reading. We have not reached a consensus on "what it means to know a word" (e.g., Anderson & Nagy, 1991; Nation, 2001) or…

  1. Decline in Physical Function and Risk for Elder Abuse Reported to Social Services in a Community-Dwelling Population of Older Adults

    PubMed Central

    Dong, XinQi; Simon, Melissa; Evans, Denis

    2012-01-01

    Objectives Elder abuse is an important public health and human rights issue and is associated with increased morbidity and mortality. This study aimed to examine the longitudinal association between decline in physical function and the risk for elder abuse. Design Prospective population-based study Setting Geographically defined community in Chicago. Participants Chicago Health and Aging Project (CHAP) is a population-based study (N=6,159), and we identified 143 CHAP participants who had elder abuse reported to social services agency from 1993–2010. Participants The primary independent variable was objectively assessed physical function using decline in physical performance testing (Tandem stand, measured walk and chair stand). Secondary independent variables were assessed using the decline in self-reported Katz, Nagi, and Rosow-Breslau scales. Outcomes were reported and confirmed elder abuse and specific subtypes of elder abuse (physical, psychological, caregiver neglect and financial exploitation). Logistic regression models were used to assess the association of decline in physical function measures and risk for elder abuse. Results After adjusting for potential confounders, every 1 point decline in physical performance testing (OR, 1.13(1.06–1.19)), Katz impairment (OR, 1.29(1.15–1.45)), Nagi impairment (OR, 1.30(1.13–1.49)) and Rosow Breslau impairment (OR, 1.42(1.15–1.74)) were associated with increased risk for elder abuse. Lowest tertiles of physical performance testing (OR, 4.92 (1.39–17.46), highest tertiles of Katz impairment (OR, 3.99 (2.18–7.31), Nagi impairment (OR, 2.37 (1.08–5.23), and Rosow Breslau impairment (2.85 (1.39–5.84) were associated with increased risk for elder abuse. Conclusion Decline in objectively assessed physical function and self-reported physical function are associated with increased risk for elder abuse. PMID:23002901

  2. Putting Two and Two Together: Middle School Students' Morphological Problem-Solving Strategies for Unknown Words

    ERIC Educational Resources Information Center

    Pacheco, Mark B.; Goodwin, Amanda P.

    2013-01-01

    Adolescents often use root word and affix knowledge to figure out unknown words. Anglin (1993) found that younger readers favor the Part-to-Whole strategy, and Tyler and Nagy (1989) confirmed the importance of root-word knowledge for middle school students. This study seeks to understand the different strategies middle school readers use so that…

  3. Lean and Efficient Software: Whole-Program Optimization of Executables

    DTIC Science & Technology

    2015-06-30

    Approved for public release; distribution is unlimited. Financial Data Contact: Krisztina Nagy T: (607) 273-7340 x.117 F : (607) 273-8752 knagy...grammatech.com Administrative Contact: Derek Burrows T: (607) 273-7340 x.113 F : (607) 273-8752 dburrows@grammatech.com Report Documentation Page...library subroutines, removing redundant argument checking and interface layers, eliminating dead code, and improving computational efficiency. In

  4. Making Sense of the Modernist Muse: Creative Cognition and Play at the Bauhaus

    ERIC Educational Resources Information Center

    Prager, Phillip

    2014-01-01

    In a review of the methodology of the Bauhaus (Germany's famous art school of the Weimar Republic era) in light of more recent scientific research on creativity and especially in light of the work of László Moholy-Nagy, the author examines the emphasis the school placed on play and positive emotions and concludes that it evinced a highly…

  5. A population-based study of physical function and risk for elder abuse reported to social service agency: findings from the Chicago health and aging project.

    PubMed

    Dong, XinQi; Simon, Melissa; Evans, Denis

    2014-10-01

    We examined the association between physical function and the risk for reported elder abuse. In the Chicago Health and Aging Project (N = 8,932), 238 participants had reported elder abuse. The independent variable was objectively assessed physical function using both directly observed physical performance testing and self-reported physical function (Katz activity of daily living scale, Nagi physical activity scale, and Rosow Breslau mobility scales). Outcomes were elder abuse and specific subtypes of elder abuse. After adjusting for confounders, lower levels of physical performance testing (OR, 2.71[1.58-4.64]), Katz impairment (OR, 1.84[1.29-2.59]), Nagi impairment (OR, 1.65[1.15-2.37]) and Rosow Breslau (OR, 1.76[1.26-2.47]) were associated with increased risk for elder abuse. Lowest levels of physical performance testing were associated with increased risk for psychological abuse (OR, 2.69[1.27-5.71]), caregiver neglect (OR, 2.66[1.22-5.79]), and financial exploitation (OR, 2.35 [1.21-4.55]). Our results may have important implications to healthcare professional, social services and other disciplines to prevent and treat elder abuse. © The Author(s) 2012.

  6. Translations on Eastern Europe, Scientific Affairs, Number 567

    DTIC Science & Technology

    1977-12-16

    becomes effective on the day of its promulgation. [signed by] Ferenc Marta general secretary 2542 CSO: 2502 11 HUNGARY ACADEMY ESTABLISHES...doctor of medical sciences, Dezso Schüler, doctor of medical sciences, Gabor Szabo , academician, Jozsef Szegi, doctor of agricultural sciences, Pal...were: Marta Dery, doctor of technical sciences, L. Gyprgy Nagy and Sandor Rohrsetzer, doctors of chemical sciences. II. The Committee of

  7. RF Energy Interaction With Electro-Optic Materials (Single Investigator Award Proposed to Address Research Topic Area 6.4. Electromagnetics and RF Circuit Integration)

    DTIC Science & Technology

    2015-12-27

    demonstration vehicles. Test and measurement of fabricated structures will be conducted to experimentally quantify RF and optical performance. Measurement...the development of coupled RF and optical structures. Both the graduate student and the undergraduate student were trained in conducting precision...research conducted for this project. The journal paper citations are: 1. L. Chen, J. Nagy, and R. M. Reano, "Patterned ion-sliced lithium niobate for

  8. East Europe Report, Political, Sociological and Military Affairs

    DTIC Science & Technology

    1985-03-19

    organizations in bringing up the main and basic features in assessing the situation and creating conditions and a mood for decisive changes in the work and...already adults , were working with passionate belief and determination day and night—perhaps applauding and chanting more than neces- sary—are not...Nagy’s handwriting . 1014 CS0: 2500/191 52 JPRS-EPS-85-035 19 March 1985 HUNGARY REPORTS ABOUT CHINESE REFORM Preliminary Discussions, Economic

  9. Important and Critical Psychological Attributes of USAF MQ-1 Predator and MQ-9 Reaper Pilots According to Subject Matter Experts

    DTIC Science & Technology

    2011-05-01

    and skills required for military-specific RPAs such as the Pioneer (e.g., Ref 20,21) and Global Hawk (Nagy JE, Muse K , Eaton G , Phillips A, U.S. Air...Analyses, Predator Pilot Front End Analysis (FEA) Report, SURVIAC-TR-06-203, Feb 2006 ; available through the Defense Technical Information Center to U.S...assessing the critical attributes (e.g., subscales of verbal and performance intelligence quotients ) prior to entering the training pipeline. Aeromedical

  10. MR 201424 Final Report Addendum

    DTIC Science & Technology

    2016-09-01

    FINAL REPORT ADDENDUM Munitions Classification Library ESTCP Project MR-201424 SEPTEMBER 2016 Mr. Craig Murray Dr. Nagi Khadr Parsons Dr...solver and multi-solver library databases, and only the TEMTADS 2X2 and the MetalMapper advanced TEM systems are supported by UX-Analyze, data on...other steps (section 3.4) before getting into the data collection activities (sections 3.5-3.7). All inversions of library quality data collected over

  11. Workshop on Prognosis of Aircraft and Space Devices, Components and Systems

    DTIC Science & Technology

    2008-02-19

    of Detection," Harry Millwater , University of Texas at San Antonio 4:00 pm "A New Approach for Investigating Crystal Stresses that Drive the...Probability of Detection, Harry Millwater , University of Texas at San Antonio This research examines the simulation of recurring automated...david.mcdowell(2>me.2;atech.edu iennifer.michaels(5),ece.2atech.edu mpm4(a),cornell .edu Millwater , Harry R. Nagy, Peter B. Pratt, David M. Dept. Mechanical

  12. Dynamic Response and Maneuvering Strategies of a Hybrid Autonomous Underwater Vehicle in Hovering

    DTIC Science & Technology

    2009-02-01

    Highlights of ECC’99, pages 391– 449. Springer, 1999. [7] F. Allgower, R. Findeisen , and Z. K. Nagy. Nonlinear model predictive con- trol: From theory...vehicle. In OCEANS, pages 2129–2134. MTS/IEEE, 2005. [17] M. Diehl, R. Findeisen , F. Allgower, H. G. Bock, and J. P. Schloder. Nominal stability of real...International Journal of Robust and Nonlinear Control, 18(8):816–830, May 2008. [22] R. Findeisen and F. Allgower. An introduction to nonlinear model

  13. Creating Robust Relation Extract and Anomaly Detect via Probabilistic Logic-Based Reasoning and Learning

    DTIC Science & Technology

    2017-11-01

    disapproval of its ideas or findings. REPORT DOCUMENTATION PAGE Form Approved OMB No. 0704-0188 The public reporting burden for this collection...information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 1. REPORT DATE (DD-MM...RESPONSIBLE PERSON JAMES M. NAGY a. REPORT U b. ABSTRACT U c. THIS PAGE U 19b. TELEPHONE NUMBER (Include area code) N/A Standard Form 298 (Rev. 8-98

  14. A Concluding Study of the Altitude Determination Deficiencies of the Service Aircraft Instrumentation Package (SAIP)

    DTIC Science & Technology

    1993-03-25

    manually . M2F=3.28083989 A=size( HTP ); TO= HTP (I,2)+273.15; PO= HTP (I,3); H0= HTP (1,1); R=287.04; GSL=9.7957; H=[]; P3=0; RAD=20820807; axis((0,5000,0,30...contributed, but I would especially like to acknowledge Bob Nagy of the Geophysics Department for his assistance in providing, and interpreting the...teet to under 250 feet at an altitude of 30,000 feet. The method does require the sounding data to be manually examined to pick out the layer. When a

  15. VizieR Online Data Catalog: W49A JCMT Spectral Legacy Survey spectroscopy (Nagy+, 2015)

    NASA Astrophysics Data System (ADS)

    Nagy, Z.; van der Tak, F. F. S.; Fuller, G. A.; Plume, R.

    2015-08-01

    We carried out the SLS observations using the 16-receptor (spatial pixel) Heterodyne Array Receiver Programme B (HARP-B, 325-375GHz) and the Auto-Correlation Spectral Imaging System (ACSIS) correlator at the James Clerk Maxwell Telescope1 (JCMT) on Mauna Kea, Hawaii. We carried out the observations in jiggle position switch mode, sampled every 7.5" for a 2x2-arcmin field centered on RA=19:10:13.4; DE=09:06:14 (J2000). (1 data file).

  16. Data on the interaction between thermal comfort and building control research.

    PubMed

    Park, June Young; Nagy, Zoltan

    2018-04-01

    This dataset contains bibliography information regarding thermal comfort and building control research. In addition, the instruction of a data-driven literature survey method guides readers to reproduce their own literature survey on related bibliography datasets. Based on specific search terms, all relevant bibliographic datasets are downloaded. We explain the keyword co-occurrences of historical developments and recent trends, and the citation network which represents the interaction between thermal comfort and building control research. Results and discussions are described in the research article entitled "Comprehensive analysis of the relationship between thermal comfort and building control research - A data-driven literature review" (Park and Nagy, 2018).

  17. Aalenian foraminiferal fauna and microfacies analyses of the Tethys Ocean Basin from the Transdanubian Range (Hungary)

    NASA Astrophysics Data System (ADS)

    Zsiborás, Gábor; Görög, Ágnes

    2016-04-01

    The early Middle Jurassic foraminiferal fauna of the Tethys Ocean Basin is hardly known. It is especially true for the Aalenian from when only Monaco et al. (1994) published some forms from Valdorbia Section, Central Italy and Wernli (1988) from Domuz Dag, Turkey. Thus the aim of our study was to give a detailed systematic description of the foraminiferal fauna and microfacies analyses of Nagy-Pisznice Section of Lábatlan and T?zköves Gorge of Bakonycsernye from the Transdanubian Range. According to several studies of Géczy} and others, the ammonite fauna indicate all Aalenian (Opalinum, Murchisonae, Concavum) biozones in both successions. 6 samples from T?zköves Gorge, 13 samples from Nagy-Pisznice were collected. Both sequences are about 3 metres thick Ammonitico Rosso type reddish grey limestone with flaser beds and nodules (Tölgyhát Limestone Formation). For the microfacies studies thin sections were made. The dominant microfacies is bioclastic wackestone predominated {Bositra} shells. To extract the microfossils, each sample was dissolved in glacial acetic acid. The microfauna consist of foraminifers, calcispheres, juvenile ammonites, ostracods, radiolarians, microgastropods and fragments of echinoderms. Throughout the Nagy-Pisznice succession, the composition of the foraminiferal fauna is relatively uniform and moderately divers. Most specimens belong to Suborder Lagenina with 60-80{%} abundance. The Suborder Spirillinina are also frequent with 20-35{%} abundance. Agglutinants are subordinated and Suborder Miliolina is absent. The most abundant genus is {Lenticulina}, its amount is more than 50{%} in some samples. {Astacolus}, {Marginulina}, {Dentalina}, {Nodosaria}, {Paralingulina} and Epistominidae are also frequent. {Eoguttulina} and {Paalzowella} are scarce. Spirillinids are represented by {Spirillina}, {Turrispirillina}, and {Coronipora} genera. The taxonomic composition of the foraminiferal fauna of T?zköves Gorge is similar to the aforesaid

  18. Mutations in the N Terminus of the Brome Mosaic Virus Polymerase Affect Genetic RNA-RNA Recombination

    PubMed Central

    Figlerowicz, M.; Nagy, P. D.; Tang, N.; Kao, C. C.; Bujarski, J. J.

    1998-01-01

    Previously, we have observed that mutations in proteins 1a and 2a, the two virally encoded components of the brome mosaic virus (BMV) replicase, can affect the frequency of recombination and the locations of RNA recombination sites (P. D. Nagy, A. Dzianott, P. Ahlquist, and J. J. Bujarski, J. Virol. 69:2547–2556, 1995; M. Figlerowicz, P. D. Nagy, and J. J. Bujarski, Proc. Natl. Acad. Sci. USA 94:2073–2078, 1997). Also, it was found before that the N-terminal domain of 2a, the putative RNA polymerase protein, participates in the interactions between 1a and 2a (C. C. Kao, R. Quadt, R. P. Hershberger, and P. Ahlquist, J. Virol. 66:6322–6329, 1992; E. O’Reilly, J. Paul, and C. C. Kao, J. Virol. 71:7526–7532, 1997). In this work, we examine how mutations within the N terminus of 2a influence RNA recombination in BMV. Because of the likely electrostatic character of 1a-2a interactions, five 2a mutants, MF1 to MF5, were generated by replacing clusters of acidic amino acids with their neutral counterparts. MF2 and MF5 retained nearly wild-type levels of 1a-2a interaction and were infectious in Chenopodium quinoa. However, compared to that in wild-type virus, the frequency of nonhomologous recombination in both MF2 and MF5 was markedly decreased. Only in MF2 was the frequency of homologous recombination reduced and the occurrence of imprecise homologous recombination increased. In MF5 there was also a 3′ shift in the positions of homologous crossovers. The observed effects of MF2 and MF5 reveal that the 2a N-terminal domain participates in different ways in homologous and in nonhomologous BMV RNA recombination. This work maps specific locations within the N terminus involved in 1a-2a interaction and in recombination and further suggests that the mechanisms of the two types of crossovers in BMV are different. PMID:9765466

  19. Mutations in the N terminus of the brome mosaic virus polymerase affect genetic RNA-RNA recombination.

    PubMed

    Figlerowicz, M; Nagy, P D; Tang, N; Kao, C C; Bujarski, J J

    1998-11-01

    Previously, we have observed that mutations in proteins 1a and 2a, the two virally encoded components of the brome mosaic virus (BMV) replicase, can affect the frequency of recombination and the locations of RNA recombination sites (P. D. Nagy, A. Dzianott, P. Ahlquist, and J. J. Bujarski, J. Virol. 69:2547-2556, 1995; M. Figlerowicz, P. D. Nagy, and J. J. Bujarski, Proc. Natl. Acad. Sci. USA 94:2073-2078, 1997). Also, it was found before that the N-terminal domain of 2a, the putative RNA polymerase protein, participates in the interactions between 1a and 2a (C. C. Kao, R. Quadt, R. P. Hershberger, and P. Ahlquist, J. Virol. 66:6322-6329, 1992; E. O'Reilly, J. Paul, and C. C. Kao, J. Virol. 71:7526-7532, 1997). In this work, we examine how mutations within the N terminus of 2a influence RNA recombination in BMV. Because of the likely electrostatic character of 1a-2a interactions, five 2a mutants, MF1 to MF5, were generated by replacing clusters of acidic amino acids with their neutral counterparts. MF2 and MF5 retained nearly wild-type levels of 1a-2a interaction and were infectious in Chenopodium quinoa. However, compared to that in wild-type virus, the frequency of nonhomologous recombination in both MF2 and MF5 was markedly decreased. Only in MF2 was the frequency of homologous recombination reduced and the occurrence of imprecise homologous recombination increased. In MF5 there was also a 3' shift in the positions of homologous crossovers. The observed effects of MF2 and MF5 reveal that the 2a N-terminal domain participates in different ways in homologous and in nonhomologous BMV RNA recombination. This work maps specific locations within the N terminus involved in 1a-2a interaction and in recombination and further suggests that the mechanisms of the two types of crossovers in BMV are different.

  20. Refractive index of B1-xGaxN semiconductors

    NASA Astrophysics Data System (ADS)

    Vyas, P. S.; Baria, J. K.; Jivani, A. R.; Gajjar, P. N.; Jani, A. R.

    2013-06-01

    A theoretical procedure is presented for the study of refractive index of ternary alloy B1-xGaxN. The calculations based on the pseudopotential formalism in which local potential coupled with the virtual crystal approximation (VCA) is applied to evaluate energy band gap at point X on the Jones-zone face, refractive index for the entire range of the alloy composition x of the ternary alloy B1-xGaxN. To include exchange and correlation effects, local field correction function due to Nagy is employed. Our results for parent compounds are compared to experiment and other available theoretical findings and showed generally good agreement. During present study it is found that the refractive index of the ternary alloy B1-xGaxN has minimum value at gallium concentration x = 0.4.

  1. The last SPR dinner awards

    NASA Astrophysics Data System (ADS)

    Tsurutani, Bruce

    1992-03-01

    Because the Solar-Planetary Relationships section of AGU has officially changed its name to Space Physics and Aeronomy (SPA), the December 10, 1991, section dinner award ceremony at the AGU Fall Meeting in San Francisco was the last of the series. Presumably an SPA dinner award series will be started under President-elect Andy Nagy.We have followed our tradition of recognizing the special talents of section members at the annual dinner. This year we had eight awardees. These awards are given in fun and are intended to be humorous. The selection committee defining the awards (the awards are changed regularly to keep people from trying to win one) and selecting the awardees will have to remain anonymous. (The committee is similar to Skull and Bones, but we are politically correct in that we allow women as members.)

  2. Electrical resistivity of liquid Na-alkali alloys

    NASA Astrophysics Data System (ADS)

    Malan, Rajesh C.; Vora, Aditya M.

    2018-05-01

    The electrical resistivity (ρ) has been investigated for the liquid Na-alkali alloys. An effort is made to extend the applicability of the potential suggested by Fiolhais and co-workers to the liquid range for alkali group. The universal parameters of the potential are used for the entire calculation. Eight different screening functions proposed by Hartree (H), Hubbard and Sham (HS), Vashishtha and Shingwi (VS), Taylor (T), Ichimaru and Utsumi (IU), Farid et al. (F), Sarkar et al. (S) and Nagy (N) are used to study the electrical resistivity (ρ) of liquid Na-alkali alloys with well-known Faber-Ziman theory along with Percus-Yevic hard sphere (PYHS) reference system. The results of electrical resistivity (ρ) are found in qualitative agreement with experimental data for the Na-K and Na-Rb alloys than those for Na-Li and Na-Cs alloys.

  3. Can we (control) Engineer the degree learning process?

    NASA Astrophysics Data System (ADS)

    White, A. S.; Censlive, M.; Neilsen, D.

    2014-07-01

    This paper investigates how control theory could be applied to learning processes in engineering education. The initial point for the analysis is White's Double Loop learning model of human automation control modified for the education process where a set of governing principals is chosen, probably by the course designer. After initial training the student decides unknowingly on a mental map or model. After observing how the real world is behaving, a strategy to achieve the governing variables is chosen and a set of actions chosen. This may not be a conscious operation, it maybe completely instinctive. These actions will cause some consequences but not until a certain time delay. The current model is compared with the work of Hollenbeck on goal setting, Nelson's model of self-regulation and that of Abdulwahed, Nagy and Blanchard at Loughborough who investigated control methods applied to the learning process.

  4. KSC-2011-6633

    NASA Image and Video Library

    2011-08-30

    VANDENBERG AIR FORCE BASE, Calif. -- The environmentally controlled transportation container holding NASA's National Polar-orbiting Operational Environmental Satellite System Preparatory Project (NPP) satellite comes to rest on the floor of the Astrotech payload processing facility on Vandenberg Air Force Base in California. NPP represents a critical first step in building the next-generation of Earth-observing satellites. NPP will carry the first of the new sensors developed for this satellite fleet, now known as the Joint Polar Satellite System (JPSS), to be launched in 2016. NPP is the bridge between NASA's Earth Observing System (EOS) satellites and the forthcoming series of JPSS satellites. The mission will test key technologies and instruments for the JPSS missions. NPP is targeted to launch Oct. 25 from Space Launch Complex-2 aboard a United Launch Alliance Delta II rocket. For more information, visit http://www.nasa.gov/NPP. Photo credit: NASA/Jerry Nagy, VAFB

  5. KSC-2011-6632

    NASA Image and Video Library

    2011-08-30

    VANDENBERG AIR FORCE BASE, Calif. -- The environmentally controlled transportation container holding NASA's National Polar-orbiting Operational Environmental Satellite System Preparatory Project (NPP) satellite is lifted from its delivery truck at the Astrotech payload processing facility on Vandenberg Air Force Base in California. NPP represents a critical first step in building the next-generation of Earth-observing satellites. NPP will carry the first of the new sensors developed for this satellite fleet, now known as the Joint Polar Satellite System (JPSS), to be launched in 2016. NPP is the bridge between NASA's Earth Observing System (EOS) satellites and the forthcoming series of JPSS satellites. The mission will test key technologies and instruments for the JPSS missions. NPP is targeted to launch Oct. 25 from Space Launch Complex-2 aboard a United Launch Alliance Delta II rocket. For more information, visit http://www.nasa.gov/NPP. Photo credit: NASA/Jerry Nagy, VAFB

  6. [Further microbiological studies of the air in a newly built (under the pavement) section of the underground railway in Budapest].

    PubMed

    Szám, L; Vedres, I; Csatai, L; Nikodemusz, I

    1983-04-01

    In three subway stations, which are "sub-pavement" stations (Budapest), microbiological air analyses were simultaneously carried out by means of sedimentation and by the use of Krotow's impactor. In the course of the examinations, which lasted eight months, the following max. values were obtained on the agar plates: 78 colonies/dm2/h and 239 colonies/m3; the rates of incidence for pathogenic and indicator bacteria were 2.7 and 1.7 per 10 plates. The strongest airflow was 0.7 m/sec. These values were obtained at the "Nagy-várad tér" station, which forms a transition to the subway stations. The "stopper effect" was found to exist here as well, although not to such an extent as in the deep subway stations, but still more pronounced than in the other two "subpavement" stations "Esceri ut" and "Határ ut". The microbiological values are at any rate more favourable than in the subway stations dealt with in an earlier paper.

  7. Retractions. Antioxidants and Redox Signaling (ARS).

    PubMed

    2012-04-01

    Due to the recent findings of an investigation led by the U.S. Office of Research Integrity, and as a direct result of the falsification and manipulation of data in the articles listed below, Antioxidants and Redox Signaling (ARS) is officially retracting the following published papers, authored by Dipak K. Das. 1. Malik G, Gorbounov N, Das S, Gurusamy N, Otani H, Maulik N, Goswami S, Das DK. Ischemic preconditioning triggers nuclear translocation of thioredoxin and its interaction with Ref-1 potentiating a survival signal through the PI-3-kinase-Akt pathway. Antioxid Redox Signal 8:2101-2109, 2006. 2. Muinck ED, Nagy N, Tirziu D, Murakami M, Gurusamy N, Goswami SK, Ghatpande S, Engelman RM, Simons M, Das DK. Protection against myocardial ischemia-reperfusion injury by the angiogenic Masterswitch protein PR 39 gene therapy: the roles of HIF1alpha stabilization and FGFR1 signaling. Antioxid Redox Signal 9:437-445, 2007. These actions reinforce the high standards to which ARS is committed.

  8. On microbial contaminants, micropseudofossils, and the oldest records of life

    USGS Publications Warehouse

    Cloud, P.; Morrison, K.

    1979-01-01

    Microbial contaminants may be introduced on outcrop as well as en route to or in the laboratory. Micropseudofossils may be natural or man-made. It is possible to recognize such misleading objects and important that they are not allowed to dilute the growing record of authentic pre-Phanerozoic life. Filamentous microbial contaminants from minute cracks in samples of ancient carbonate rocks from Brazil (perhaps 1 Ga old) and South Africa (???2.3 Ga old) are similar to occurrences previously described as fossils. Published records of supposedly Archean microbial life also include microcontaminants and laboratory artifacts. Although microstructures from sedimentary rocks of the Swaziland system could be fossils, they are not demonstrably so. The oldest structurally preserved fossils yet known seem to be the filaments described by Lois Nagy from stromatolitic limestone in the ???2.3 Ga old Malmani Dolomite of South Africa. It will be difficult to establish unequivocal older records in the absence of definitive ultrastructural or micro-chemical evidence. ?? 1979.

  9. Temperature and speed of testing influence on the densification and recovery of polyurethane foams

    NASA Astrophysics Data System (ADS)

    Apostol, Dragoş Alexandru; Constantinescu, Dan Mihai

    2013-02-01

    Polyurethane foams with densities of 35, 93, and 200 kg/m3 were tested in compression at three levels of temperatures as: -60 °C, 23 °C, and 80 °C. The influence of speed of testing from 2 mm/min up to 6 m/s (0.0014 to 545 s-1) on the response of the foams is analyzed. Testing is done separately on the rise direction and on the in-plane direction of the foams, and differences in their behavior are commented. With interpolation functions which approximate the plateau and densification region, the specific strain energy is calculated together with the energy efficiency and onset strain of densification. A Nagy-type phenomenological strain-rate-dependent model is proposed to generate engineering stress-strain curves and is validated through comparison with experimental stress-strain curves obtained at different speeds of testing. Starting from a reference experimental curve, two material parameters which are density and temperature dependent are established. Foam recovery for each density of the polyurethane foams is analyzed as a function of direction of testing, temperature, and speed of testing.

  10. Two-level leader-follower organization in pigeon flocks

    NASA Astrophysics Data System (ADS)

    Chen, Zhiyong; Zhang, Hai-Tao; Chen, Xi; Chen, Duxin; Zhou, Tao

    2015-10-01

    The most attractive trait of collective animal behavior is the emergence of highly ordered structures (Cavagna A., Giardina I. and Ginelli F., Phys. Rev. Lett., 110 (2013) 168107). It has been conjectured that the interaction mechanism in pigeon flock dynamics follows a hierarchical leader-follower influential network (Nagy M., Ákos Z., Biro D. and Vicsek T., Nature, 464 (2010) 890). In this paper, a new observation is reported that shows that pigeon flocks actually adopt a much simpler two-level interactive network composed of one leader and some followers. By statistically analyzing the same experimental dataset, we show that for a certain period of time a sole leader determines the motion of the flock while the remaining birds are all followers directly copying the leader's direction with specific time delays. This simple two-level despotic organization is expected to save both motional energy and communication cost, while retaining agility and robustness of the whole group. From an evolutionary perspective, our results suggest that a two-level organization of group flight may be more efficient than a multilevel topology for small pigeon flocks.

  11. Close-up of Shuttle tire after LSRA test

    NASA Technical Reports Server (NTRS)

    1995-01-01

    One of the final tests of the CV-990 Landing Systems Research Aircraft (LSRA) in August, 1995 at NASA's Dryden Flight Research Center, Edwards, California, resulted in the destruction of the wheel, following a fire caused by a mixture of heat, aluminum particles, and rubber. Following successful tests of tire wear at Edwards and the Kennedy Space Center, Fl., this series of roll-on-rim tests determined the failure modes ofwheels for the space shuttle. The aluminum wheel locked in postion and was ground to within four inches of the axle before the test concluded. The series of 155 test missions for the space shuttle program provided extensive data about the life and endurance of the shuttle tire systems and helped raise the shuttle crosswind landing limits at Kennedy. Project engineer Christopher J. Nagy said, 'NASA pilots Gordon Fullerton and Terry Rager did a superb job of flying the aircraft in many difficult test situations, at speeds higher than the aircraft was intended to land, without once losing a single flight.'

  12. Close-up of Shuttle tire after LSRA test

    NASA Technical Reports Server (NTRS)

    1995-01-01

    One of the final tests of the CV-990 Landing Systems Research Aircraft (LSRA) in August, 1995 at NASA's Dryden Flight Research Center, Edwards, California, resulted in the destruction of the wheel, following a fire caused by a mixture of heat, aluminum particles, and rubber. Following successful tests of tire wear at Edwards and the Kennedy Space Center, Fla., this series of roll-on-rim tests determined the failure modes of wheels for the space shuttle. In one test, the aluminum wheel locked in position and was ground to within four inches of the axle before the test concluded. The series of 155 test missions for the space shuttle program provided extensive data about the life and endurance of the shuttle tire systems and helped raise the shuttle crosswind landing limits at Kennedy. Project engineer Christopher J. Nagy said, 'NASA pilots Gordon Fullerton and Terry Rager did a superb job of flying the aircraft in many difficult test situations, at speeds higher than the aircraft was intended to land, without once losing a single test flight.'

  13. KSC-08pd3502

    NASA Image and Video Library

    2008-11-04

    VANDENBERG AIR FORCE BASE, Calif. – The NOAA-N Prime spacecraft is positioned for movement into NASA's Hazardous Processing Facility on Vandenberg Air Force Base in California. NOAA-N Prime was built by Lockheed Martin Space Systems Company for its Advanced Television Infrared Observational Satellites -N series. It is the latest polar-orbiting operational environmental weather satellite developed by NASA for the National Oceanic and Atmospheric Administration. The satellite will provide a platform to support environmental monitoring instruments for imaging and measuring the Earth's atmosphere, its surface and cloud cover, including Earth radiation, atmospheric ozone, aerosol distribution, sea surface temperature and vertical temperature and water profiles in the troposphere and stratosphere. The satellite will assist in measuring proton and electron fluxes at orbit altitude, collecting data from remote platforms to assist the Search and Rescue Satellite-Aided Tracking system. The satellite will be launched from the Western Range at Vandenberg AFB by a United Launch Alliance two-stage Delta II rocket managed by NASA's Launch Service Program at Kennedy. Photo credit: NASA/Jerry Nagy, VAFB

  14. KSC-08pd3501

    NASA Image and Video Library

    2008-11-04

    VANDENBERG AIR FORCE BASE, Calif. – The NOAA-N Prime spacecraft is offloaded from the transporter at NASA's Hazardous Processing Facility on Vandenberg Air Force Base in California. NOAA-N Prime was built by Lockheed Martin Space Systems Company for its Advanced Television Infrared Observational Satellites -N series. It is the latest polar-orbiting operational environmental weather satellite developed by NASA for the National Oceanic and Atmospheric Administration. The satellite will provide a platform to support environmental monitoring instruments for imaging and measuring the Earth's atmosphere, its surface and cloud cover, including Earth radiation, atmospheric ozone, aerosol distribution, sea surface temperature and vertical temperature and water profiles in the troposphere and stratosphere. The satellite will assist in measuring proton and electron fluxes at orbit altitude, collecting data from remote platforms to assist the Search and Rescue Satellite-Aided Tracking system. The satellite will be launched from the Western Range at Vandenberg AFB by a United Launch Alliance two-stage Delta II rocket managed by NASA's Launch Service Program at Kennedy. Photo credit: NASA/Jerry Nagy, VAFB

  15. KSC-08pd3500

    NASA Image and Video Library

    2008-11-04

    VANDENBERG AIR FORCE BASE, Calif. – The NOAA-N Prime spacecraft arrives at NASA's Hazardous Processing Facility on Vandenberg Air Force Base in California. NOAA-N Prime was built by Lockheed Martin Space Systems Company for its Advanced Television Infrared Observational Satellites -N series. It is the latest polar-orbiting operational environmental weather satellite developed by NASA for the National Oceanic and Atmospheric Administration. The satellite will provide a platform to support environmental monitoring instruments for imaging and measuring the Earth's atmosphere, its surface and cloud cover, including Earth radiation, atmospheric ozone, aerosol distribution, sea surface temperature and vertical temperature and water profiles in the troposphere and stratosphere. The satellite will assist in measuring proton and electron fluxes at orbit altitude, collecting data from remote platforms to assist the Search and Rescue Satellite-Aided Tracking system. The satellite will be launched from the Western Range at Vandenberg AFB by a United Launch Alliance two-stage Delta II rocket managed by NASA's Launch Service Program at Kennedy. Photo credit: NASA/Jerry Nagy, VAFB

  16. KSC-08pd3499

    NASA Image and Video Library

    2008-11-04

    VANDENBERG AIR FORCE BASE, Calif. – The NOAA-N Prime spacecraft is offloaded from a C-5 aircraft after arrival at Vandenberg Air Force Base Airfield in California. NOAA-N Prime was built by Lockheed Martin Space Systems Company for its Advanced Television Infrared Observational Satellites -N series. It is the latest polar-orbiting operational environmental weather satellite developed by NASA for the National Oceanic and Atmospheric Administration. The satellite will provide a platform to support environmental monitoring instruments for imaging and measuring the Earth's atmosphere, its surface and cloud cover, including Earth radiation, atmospheric ozone, aerosol distribution, sea surface temperature and vertical temperature and water profiles in the troposphere and stratosphere. The satellite will assist in measuring proton and electron fluxes at orbit altitude, collecting data from remote platforms to assist the Search and Rescue Satellite-Aided Tracking system. The satellite will be launched from the Western Range at Vandenberg AFB by a United Launch Alliance two-stage Delta II rocket managed by NASA's Launch Service Program at Kennedy. Photo credit: NASA/Jerry Nagy, VAFB

  17. KSC-08pd3503

    NASA Image and Video Library

    2008-11-04

    VANDENBERG AIR FORCE BASE, Calif. – Workers move the NOAA-N Prime spacecraft into NASA's Hazardous Processing Facility on Vandenberg Air Force Base in California. NOAA-N Prime was built by Lockheed Martin Space Systems Company for its Advanced Television Infrared Observational Satellites -N series. It is the latest polar-orbiting operational environmental weather satellite developed by NASA for the National Oceanic and Atmospheric Administration. The satellite will provide a platform to support environmental monitoring instruments for imaging and measuring the Earth's atmosphere, its surface and cloud cover, including Earth radiation, atmospheric ozone, aerosol distribution, sea surface temperature and vertical temperature and water profiles in the troposphere and stratosphere. The satellite will assist in measuring proton and electron fluxes at orbit altitude, collecting data from remote platforms to assist the Search and Rescue Satellite-Aided Tracking system. The satellite will be launched from the Western Range at Vandenberg AFB by a United Launch Alliance two-stage Delta II rocket managed by NASA's Launch Service Program at Kennedy. Photo credit: NASA/Jerry Nagy, VAFB

  18. KSC-08pd3498

    NASA Image and Video Library

    2008-11-04

    VANDENBERG AIR FORCE BASE, Calif. – The NOAA-N Prime spacecraft is offloaded from a C-5 aircraft after arrival at Vandenberg Air Force Base Airfield in California. NOAA-N Prime was built by Lockheed Martin Space Systems Company for its Advanced Television Infrared Observational Satellites -N series. It is the latest polar-orbiting operational environmental weather satellite developed by NASA for the National Oceanic and Atmospheric Administration. The satellite will provide a platform to support environmental monitoring instruments for imaging and measuring the Earth's atmosphere, its surface and cloud cover, including Earth radiation, atmospheric ozone, aerosol distribution, sea surface temperature and vertical temperature and water profiles in the troposphere and stratosphere. The satellite will assist in measuring proton and electron fluxes at orbit altitude, collecting data from remote platforms to assist the Search and Rescue Satellite-Aided Tracking system. The satellite will be launched from the Western Range at Vandenberg AFB by a United Launch Alliance two-stage Delta II rocket managed by NASA's Launch Service Program at Kennedy. Photo credit: NASA/Jerry Nagy, VAFB

  19. Quantized Algebras of Functions on Homogeneous Spaces with Poisson Stabilizers

    NASA Astrophysics Data System (ADS)

    Neshveyev, Sergey; Tuset, Lars

    2012-05-01

    Let G be a simply connected semisimple compact Lie group with standard Poisson structure, K a closed Poisson-Lie subgroup, 0 < q < 1. We study a quantization C( G q / K q ) of the algebra of continuous functions on G/ K. Using results of Soibelman and Dijkhuizen-Stokman we classify the irreducible representations of C( G q / K q ) and obtain a composition series for C( G q / K q ). We describe closures of the symplectic leaves of G/ K refining the well-known description in the case of flag manifolds in terms of the Bruhat order. We then show that the same rules describe the topology on the spectrum of C( G q / K q ). Next we show that the family of C*-algebras C( G q / K q ), 0 < q ≤ 1, has a canonical structure of a continuous field of C*-algebras and provides a strict deformation quantization of the Poisson algebra {{C}[G/K]} . Finally, extending a result of Nagy, we show that C( G q / K q ) is canonically KK-equivalent to C( G/ K).

  20. Well-posedness of the Einstein-Euler system in asymptotically flat spacetimes: The constraint equations

    NASA Astrophysics Data System (ADS)

    Brauer, Uwe; Karp, Lavi

    This paper deals with the construction of initial data for the coupled Einstein-Euler system. We consider the condition where the energy density might vanish or tend to zero at infinity, and where the pressure is a fractional power of the energy density. In order to achieve our goals we use a type of weighted Sobolev space of fractional order. The common Lichnerowicz-York scaling method (Choquet-Bruhat and York, 1980 [9]; Cantor, 1979 [7]) for solving the constraint equations cannot be applied here directly. The basic problem is that the matter sources are scaled conformally and the fluid variables have to be recovered from the conformally transformed matter sources. This problem has been addressed, although in a different context, by Dain and Nagy (2002) [11]. We show that if the matter variables are restricted to a certain region, then the Einstein constraint equations have a unique solution in the weighted Sobolev spaces of fractional order. The regularity depends upon the fractional power of the equation of state.

  1. Cross-linked fibrin degradation products (D-dimer), plasma cytokines, and cognitive decline in community-dwelling elderly persons.

    PubMed

    Wilson, Craig J; Cohen, Harvey Jay; Pieper, Carl F

    2003-10-01

    To investigate the effect of coagulation and inflammatory pathway activation on future cognitive decline in older persons. Prospective cohort study. Rural and urban communities in North Carolina. Community-dwelling older people enrolled in the Duke Established Populations for Epidemiologic Studies of the Elderly in 1986. In 1992, blood was drawn for assay of D-dimer (1,723 subjects), Interleukin-6 (1,726 subjects), and other cytokines (1,551 subjects). Cognitive and functional assessments were performed in 1986, 1989, 1992, and 1996. Cognition was measured using the Short Portable Mental Status Questionnaire. Cognitive decline over a 4-year period was significantly correlated (P<.001) with D-dimer, age, race, and physical performance status as measured using the Rosow-Breslau and Nagi instruments. After controlling for demographics, functional status, and comorbidities, D-dimer remained predictive of cognitive decline. Proinflammatory cytokines were not associated with current cognitive status in cross-sectional analyses or with incident cognitive decline in prospective analyses. In a large sample of community-dwelling elders, higher levels of D-dimer were predictive of cognitive decline over a 4-year period. No clinically significant associations were found between age-related peripheral cytokine dysregulation and cognition.

  2. Global modeling of thermospheric airglow in the far ultraviolet

    NASA Astrophysics Data System (ADS)

    Solomon, Stanley C.

    2017-07-01

    The Global Airglow (GLOW) model has been updated and extended to calculate thermospheric emissions in the far ultraviolet, including sources from daytime photoelectron-driven processes, nighttime recombination radiation, and auroral excitation. It can be run using inputs from empirical models of the neutral atmosphere and ionosphere or from numerical general circulation models of the coupled ionosphere-thermosphere system. It uses a solar flux module, photoelectron generation routine, and the Nagy-Banks two-stream electron transport algorithm to simultaneously handle energetic electron distributions from photon and auroral electron sources. It contains an ion-neutral chemistry module that calculates excited and ionized species densities and the resulting airglow volume emission rates. This paper describes the inputs, algorithms, and code structure of the model and demonstrates example outputs for daytime and auroral cases. Simulations of far ultraviolet emissions by the atomic oxygen doublet at 135.6 nm and the molecular nitrogen Lyman-Birge-Hopfield bands, as viewed from geostationary orbit, are shown, and model calculations are compared to limb-scan observations by the Global Ultraviolet Imager on the TIMED satellite. The GLOW model code is provided to the community through an open-source academic research license.

  3. Climate vulnerability of drinking water supplies

    NASA Astrophysics Data System (ADS)

    Selmeczi, Pál; Homolya, Emese; Rotárné Szalkai, Ágnes

    2016-04-01

    Extreme weather conditions in Hungary led to difficulties in drinking water management on diverse occasions in the past. Due to reduced water resources and the coexisting high demand for drinking water in dry summer periods the availability of a number of water supplies became insufficient therefore causing limitations in water access. In some other cases, as a result of floods and flash floods over karstic areas evolving in consequence of excessive precipitation, several water supplies had to be excluded in order to avoid the risk of infections. More frequent occurrence of extreme weather conditions and further possible changes in the future induce the necessity for an analysis of the vulnerability of drinking water resources to climate change. Since 95% of the total drinking water supply in Hungary originates from subsurface layers, significance of groundwater resources is outstanding. The aim of our work carried out in the frames of the NAGiS (National Adaptation Geo-information System) project was to build up a methodology for the study and determination of the vulnerability of drinking water supplies to climate. The task covered analyses of climatic parameters influencing drinking water supplies principally and hydrogeological characteristics of the geological media that significantly determines vulnerability. Effects on drinking water resources and their reduction or exclusion may imply societal and economic consequences therefore we extended the analyses to the investigation of possibilities concerning the adaptation capacity to changed conditions. We applied the CIVAS (Climate Impact and Vulnerability Assessment Scheme) model developed in the frames of the international climate research project CLAVIER (Climate Change and Variability: Impact on Central and Eastern Europe) to characterize climate vulnerability of drinking water supplies. The CIVAS model, being based on the combined evaluation of exposure, sensitivity and adaptability, provides a unified

  4. Effect of nagilactone E on cell morphology and glucan biosynthesis in budding yeast Saccharomyces cerevisiae.

    PubMed

    Hayashi, Kengo; Yamaguchi, Yoshihiro; Ogita, Akira; Tanaka, Toshio; Kubo, Isao; Fujita, Ken-Ichi

    2018-05-14

    Nagilactones are norditerpene dilactones isolated from the root bark of Podocarpus nagi. Although nagilactone E has been reported to show antifungal activities, its activity is weaker than that of antifungals on the market. Nagilactone E enhances the antifungal activity of phenylpropanoids such as anethole and isosafrole against nonpathogenic Saccharomyces cerevisiae and pathogenic Candida albicans. However, the detailed mechanisms underlying the antifungal activity of nagilactone E itself have not yet been elucidated. Therefore, we investigated the antifungal mechanisms of nagilactone E using S. cerevisiae. Although nagilactone E induced lethality in vegetatively growing cells, it did not affect cell viability in non-growing cells. Nagilactone E-induced morphological changes in the cells, such as inhomogeneous thickness of the glucan layer and leakage of cytoplasm. Furthermore, a dose-dependent decrease in the amount of newly synthesized (1, 3)-β-glucan was detected in the membrane fractions of the yeast incubated with nagilactone E. These results suggest that nagilactone E exhibits an antifungal activity against S. cerevisiae by depending on cell wall fragility via the inhibition of (1, 3)-β-glucan biosynthesis. Additionally, we confirmed nagilactone E-induced morphological changes of a human pathogenic fungus Aspergillus fumigatus. Therefore, nagilactone E is a potential antifungal drug candidate with fewer adverse effects. Copyright © 2018 Elsevier B.V. All rights reserved.

  5. Psychiatric versus physical disabilities: A comparison of barriers and facilitators to employment.

    PubMed

    Sevak, Purvi; Khan, Shamima

    2017-06-01

    Guided by the social model of disability (Nagi, 1965), this study aims to better identify barriers to and facilitators of employment for individuals with psychiatric disabilities and how these factors may differ for individuals with physical disabilities. Our analysis uses data from the Survey of Disability and Employment on 2,148 individuals with psychiatric disabilities, physical disabilities, or both who in 2014 applied for services from 1 of 3 state vocational rehabilitation (VR) agencies. We identify type of disability based on respondents' open-ended descriptions of their impairments. We use univariate statistics and multivariate regression estimates to compare employment history, and potential barriers to and facilitators of employment between individuals with psychiatric and physical disabilities. VR applicants with psychiatric disabilities have had longer periods of nonemployment than individuals with physical disabilities alone. They are significantly more likely than individuals with physical disabilities alone to report nonhealth reasons, such as getting fired and lacking skills, as barriers to employment. We found that a number of accommodations, including flexible schedules and modified work duties, are significantly associated with continued employment. VR counselors should be aware that although most applicants with psychiatric disabilities place a great deal of importance on being employed, they face additional barriers to employment. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  6. Evaluation of elemental status of ancient human bone samples from Northeastern Hungary dated to the 10th century AD by XRF

    NASA Astrophysics Data System (ADS)

    János, I.; Szathmáry, L.; Nádas, E.; Béni, A.; Dinya, Z.; Máthé, E.

    2011-11-01

    The present study is a multielemental analysis of bone samples belonging to skeletal individuals originating from two contemporaneous (10th century AD) cemeteries (Tiszavasvári Nagy-Gyepáros and Nagycserkesz-Nádasibokor sites) in Northeastern Hungary, using the XRF analytical technique. Emitted X-rays were detected in order to determine the elemental composition of bones and to appreciate the possible influence of the burial environment on the elemental content of the human skeletal remains. Lumbar vertebral bodies were used for analysis. Applying the ED(P)XRF technique concentration of the following elements were determined: P, Ca, K, Na, Mg, Al, Cl, Mn, Fe, Zn, Br and Sr. The results indicated post mortem mineral exchange between the burial environment (soil) and bones (e.g. the enhanced levels of Fe and Mn) and referred to diagenetic alteration processes during burials. However, other elements such as Zn, Sr and Br seemed to be accumulated during the past life. On the basis of statistical analysis, clear separation could not be observed between the two excavation sites in their bone elemental concentrations which denoted similar diagenetic influences, environmental conditions. The enhanced levels of Sr might be connected with the past dietary habits, especially consumption of plant food.

  7. A numerical study of self-sustained oscillations in wind instruments

    NASA Astrophysics Data System (ADS)

    Rendon, Pablo L.; Velasco-Segura, Roberto

    2017-11-01

    The study of sustained notes in wind musical instruments in realistic conditions requires consideration of both excitation and propagation mechanisms, and the manner in which these two interact. Further, to model adequately acoustic propagation inside the instrument, a variety of competing effects must be taken into account, such as nonlinearity, thermoviscous attenuation and radiation at the open end. Physical solutions also involve some degree of feedback at the excitation end, and here we propose the simplest boundary conditions possible at this end, given by a simple harmonic oscillator with fixed stiffness. By feeding single-frequency acoustic waves into the system we are able to study the formation of self-sustained oscillations, which are stationary states associated with resonance frequencies, and also to observe transitory states. Visualizations are presented of waves traveling in both directions. As expected, resonance frequencies are dependent on the stiffness parameter, and this dependence is examined. The full-wave simulation is performed in the time domain over a 2D spatial domain assuming axial symmetry, and it is based on a previously validated open source code, using a finite volume method (FiVoNAGI) implemented in a GPU [Velasco-Segura & Rendn, 2015]. The authors acknowledge the financial support of DGAPA-UNAM through project PAPIIT IG100717.

  8. The functional IME: A linkage of expertise across the disability continuum.

    PubMed

    Clifton, David W

    2006-01-01

    Disability assessment remains a significant challenge especially in welfare systems like workers' compensation and disability insurance. Many of today's managed care strategies do not impact on the seminal issue of return to gainful employment. Employers, insurers, attorneys and case managers routinely request independent medical examinations (IMEs) as a means of determining degree of disability, functional limitations, work restrictions and "estimated" physical capacities. However, this approach is limited because physicians are not trained in the functional model of disability assessment. IMEs address pathology and impairments which represent a portion of the disability continuum described by the World Health Organization, Nagi, Guccione and others [e.g. pathology-impairment-disability-handicap]. Functional capacity evaluations or FCEs are often performed by physical and occupational therapists who are trained in a function-based model of disability assessment. Unlike an IME physician who completes "Estimated Physical Capacities", therapists measure actual physical functioning. The value of both IMEs and FCEs can be enhanced through a "functional IME" that combines both models; medical-based examination and a function-based disability evaluation. This combination enhances the assessment of the relationship of pathology to impairment and impairment to disability status especially, in musculoskeletal disorders which tend to drive costs in workers' compensation.

  9. Opportunities investigating the thermosphere/ionosphere system by low Earth orbiting satellite missions (Invited)

    NASA Astrophysics Data System (ADS)

    Stolle, C.; Park, J.; Luhr, H.

    2013-12-01

    New opportunities for investigating the thermosphere/ionosphere interactions arise from in situ measurements on board low Earth orbiting satellites. Ten years of successful operation of the CHAMP satellite mission at a unique orbit altitude of about 400 km revealed many interesting features of the coupling between the thermosphere and ionosphere and the different atmospheric layers. Examples are the investigations of signatures of stratospheric warming events that are known to change significantly the dynamics of the equatorial ionosphere. It was shown that these modifications are due to an enhancement of lunar tidal effects, e.g. reflected in the thermospheric zonal wind, in the equatorial electroje or in the eastward electric field. Another topic concerns the energy deposit in the F-region though cooling of the thermal electron gas caused by elastic and inelastic processes (Schunk and Nagy, 2009). We find that a significant deposition is present during day at mid latitudes. At low latitudes the energy flux remain important until midnight. Observed heating rates depend on the satellite altitudes, but they are globally available from the CHAMP data. Further enhanced investigations are expected from ESA's three-satellite Swarm mission with a launch planned in 2014. The mission will provide observations of electron density, electron and ion temperature, ion drift and the electric field together with neutral density and winds. High-precision magnetic field observations will allow monitoring ionospheric currents.

  10. Reduced-cost second-order algebraic-diagrammatic construction method for excitation energies and transition moments

    NASA Astrophysics Data System (ADS)

    Mester, Dávid; Nagy, Péter R.; Kállay, Mihály

    2018-03-01

    A reduced-cost implementation of the second-order algebraic-diagrammatic construction [ADC(2)] method is presented. We introduce approximations by restricting virtual natural orbitals and natural auxiliary functions, which results, on average, in more than an order of magnitude speedup compared to conventional, density-fitting ADC(2) algorithms. The present scheme is the successor of our previous approach [D. Mester, P. R. Nagy, and M. Kállay, J. Chem. Phys. 146, 194102 (2017)], which has been successfully applied to obtain singlet excitation energies with the linear-response second-order coupled-cluster singles and doubles model. Here we report further methodological improvements and the extension of the method to compute singlet and triplet ADC(2) excitation energies and transition moments. The various approximations are carefully benchmarked, and conservative truncation thresholds are selected which guarantee errors much smaller than the intrinsic error of the ADC(2) method. Using the canonical values as reference, we find that the mean absolute error for both singlet and triplet ADC(2) excitation energies is 0.02 eV, while that for oscillator strengths is 0.001 a.u. The rigorous cutoff parameters together with the significantly reduced operation count and storage requirements allow us to obtain accurate ADC(2) excitation energies and transition properties using triple-ζ basis sets for systems of up to one hundred atoms.

  11. Effect of Pressure on Some Optical Properties of GaxIn1-xP Semiconductors

    NASA Astrophysics Data System (ADS)

    Vyas, P.; Gajjar, P.; Jani, A.

    2013-06-01

    A theoretical procedure is presented for the study of optical properties of ternary alloy GaxIn1-xP. The calculations are based on the pseudopotential formalism in which local potential coupled with the virtual crystal approximation (VCA) is applied to evaluate the effect of pressure on the optical properties like refractive index, electronic polarizability, plasmon energy, dielectric constant and equation of state for gallium concentration x = 0, 0.25, 0.50, 0.75 and 1 of the ternary alloy GaxIn1-xP. To incorporate the screening effect, local field correction functions due to Hartree, Taylor, Ichimaru et al. and Nagy are employed. The refractive index, electronic polarizability and dielectric constant computed for the parent binary compounds GaP and InP are found to be satisfactorily agreeing with the experimental report. It is seen that the refractive index of GaxIn1-xP decreases nonlinearly with the increase in pressure. The results obtained using Hartree's screening functions are not very close to the experimental data as it does not include any exchange and correlation effects. Overall good agreement with the experimental and other theoretical findings confirms the application. The author P. S. Vyas is thankful to UGC, New Delhi, India for providing financial support under minor research project No. F.: 47-651/08(WRO).

  12. Analysis of hepatitis C virus RNA dimerization and core–RNA interactions

    PubMed Central

    Ivanyi-Nagy, Roland; Kanevsky, Igor; Gabus, Caroline; Lavergne, Jean-Pierre; Ficheux, Damien; Penin, François; Fossé, Philippe; Darlix, Jean-Luc

    2006-01-01

    The core protein of hepatitis C virus (HCV) has been shown previously to act as a potent nucleic acid chaperone in vitro, promoting the dimerization of the 3′-untranslated region (3′-UTR) of the HCV genomic RNA, a process probably mediated by a small, highly conserved palindromic RNA motif, named DLS (dimer linkage sequence) [G. Cristofari, R. Ivanyi-Nagy, C. Gabus, S. Boulant, J. P. Lavergne, F. Penin and J. L. Darlix (2004) Nucleic Acids Res., 32, 2623–2631]. To investigate in depth HCV RNA dimerization, we generated a series of point mutations in the DLS region. We find that both the plus-strand 3′-UTR and the complementary minus-strand RNA can dimerize in the presence of core protein, while mutations in the DLS (among them a single point mutation that abolished RNA replication in a HCV subgenomic replicon system) completely abrogate dimerization. Structural probing of plus- and minus-strand RNAs, in their monomeric and dimeric forms, indicate that the DLS is the major if not the sole determinant of UTR RNA dimerization. Furthermore, the N-terminal basic amino acid clusters of core protein were found to be sufficient to induce dimerization, suggesting that they retain full RNA chaperone activity. These findings may have important consequences for understanding the HCV replicative cycle and the genetic variability of the virus. PMID:16707664

  13. Analysis of hepatitis C virus RNA dimerization and core-RNA interactions.

    PubMed

    Ivanyi-Nagy, Roland; Kanevsky, Igor; Gabus, Caroline; Lavergne, Jean-Pierre; Ficheux, Damien; Penin, François; Fossé, Philippe; Darlix, Jean-Luc

    2006-01-01

    The core protein of hepatitis C virus (HCV) has been shown previously to act as a potent nucleic acid chaperone in vitro, promoting the dimerization of the 3'-untranslated region (3'-UTR) of the HCV genomic RNA, a process probably mediated by a small, highly conserved palindromic RNA motif, named DLS (dimer linkage sequence) [G. Cristofari, R. Ivanyi-Nagy, C. Gabus, S. Boulant, J. P. Lavergne, F. Penin and J. L. Darlix (2004) Nucleic Acids Res., 32, 2623-2631]. To investigate in depth HCV RNA dimerization, we generated a series of point mutations in the DLS region. We find that both the plus-strand 3'-UTR and the complementary minus-strand RNA can dimerize in the presence of core protein, while mutations in the DLS (among them a single point mutation that abolished RNA replication in a HCV subgenomic replicon system) completely abrogate dimerization. Structural probing of plus- and minus-strand RNAs, in their monomeric and dimeric forms, indicate that the DLS is the major if not the sole determinant of UTR RNA dimerization. Furthermore, the N-terminal basic amino acid clusters of core protein were found to be sufficient to induce dimerization, suggesting that they retain full RNA chaperone activity. These findings may have important consequences for understanding the HCV replicative cycle and the genetic variability of the virus.

  14. Precise computation of the direct and indirect topographic effects of Helmert's 2nd method of condensation using SRTM30 digital elevation model

    NASA Astrophysics Data System (ADS)

    Wang, Y.

    2011-01-01

    The direct topographic effect (DTE) and indirect topographic effect (ITE) of Helmert's 2nd method of condensation are computed using the digital elevation model (DEM) SRTM30 in 30 arc-seconds globally. The computations assume a constant density of the topographic masses. Closed formulas are used in the inner zone of half degree, and Nagy's formulas are used in the innermost column to treat the singularity of integrals. To speed up the computations, 1-dimensional fast Fourier transform (1D FFT) is applied in outer zone computations. The computation accuracy is limited to 0.1 mGal and 0.1cm for the direct and indirect effect, respectively. The mean value and standard deviation of the DTE are -0.8 and ±7.6 mGal over land areas. The extreme value -274.3 mGal is located at latitude -13.579° and longitude 289.496°, at the height of 1426 meter in the Andes Mountains. The ITE is negative everywhere and has its minimum of -235.9 cm at the peak of Himalayas (8685 meter). The standard deviation and mean value over land areas are ±15.6 cm and -6.4 cm, respectively. Because the Stokes kernel does not contain the zero and first degree spherical harmonics, the mean value of the ITE can't be compensated through the remove-restore procedure under the Stokes-Helmert scheme, and careful treatment of the mean value in the ITE is required.

  15. Soil, vegetation and total organic carbon stock development in self-restoring abandoned vineyards

    NASA Astrophysics Data System (ADS)

    József Novák, Tibor; Incze, József; Spohn, Marie; Giani, Luise

    2016-04-01

    Abandoned vineyard's soil and vegetation development was studied on Tokaj Nagy-Hill, which is one of the traditional wine-producing regions of Hungary, it is declared as UNESCO World Heritage site as cultural landscape. Spatial distribution and pattern of vineyards were changing during the last several hundreds of years, therefore significant part of abandoned vineyards were subjected to long-term spontaneous secondary succession of vegetation and self-restoration of soils in absence of later cultivation. Two chronosequences of spontaneously regenerating vineyard abandonments, one on south (S-sequence) and one on southwest (SW-sequence) slope with differing times since their abandonment (193, 142, 101, 63, 39 and 14 years), were compiled and studied. The S-sequence was 25-35% sloped and strongly eroded, and the SW-sequence was 17-25% sloped and moderately eroded. The sites were investigated in respect of vegetation characteristics, soil physico-chemical characteristics, total organic carbon stocks (TOC stocks), accumulation rates of total organic carbon (TOC accumulation rates), and soil profiles, which were classified according to the World Reference Base (WRB) 2014. Vegetation development resulted in shrub-grassland mosaics, supplemented frequently by protected forb species and forest development at the earliest abandonment in S-sequence, and predominantly to forest vegetation in SW-sequence, where trees were only absent at the 63 and 14 years old abandonment sites. In all sites soils on level of reference groups according to WRB were classified, and Cambisols, Regosols, Calcisols, Leptosols, Chernozems and Phaeozems were found. Soils of the S-sequence show shallow remnants of loess cover with colluvic and redeposited soil materials containing 15-65% skeletal volcanic rock of weathering products coated by secondary calcium carbonates. The SW-sequence profiles are developed on deep loess or loess derivatives. The calcium-carbonate content was higher in profiles of

  16. Exploratory study of fission product yields of neutron-induced fission of 235U , 238U , and 239Pu at 8.9 MeV

    NASA Astrophysics Data System (ADS)

    Bhatia, C.; Fallin, B. F.; Gooden, M. E.; Howell, C. R.; Kelley, J. H.; Tornow, W.; Arnold, C. W.; Bond, E.; Bredeweg, T. A.; Fowler, M. M.; Moody, W.; Rundberg, R. S.; Rusev, G. Y.; Vieira, D. J.; Wilhelmy, J. B.; Becker, J. A.; Macri, R.; Ryan, C.; Sheets, S. A.; Stoyer, M. A.; Tonchev, A. P.

    2015-06-01

    Using dual-fission chambers each loaded with a thick (200 -400 -mg /c m2) actinide target of 235 ,238U or 239Pu and two thin (˜10 -100 -μ g /c m2) reference foils of the same actinide, the cumulative yields of fission products ranging from 92Sr to 147Nd have been measured at En= 8.9 MeV . The 2H(d ,n ) 3He reaction provided the quasimonoenergetic neutron beam. The experimental setup and methods used to determine the fission product yield (FPY) are described, and results for typically eight high-yield fission products are presented. Our FPYs for 235U(n ,f ) , 238U(n ,f ) , and 239Pu(n ,f ) at 8.9 MeV are compared with the existing data below 8 MeV from Glendenin et al. [Phys. Rev. C 24, 2600 (1981), 10.1103/PhysRevC.24.2600], Nagy et al. [Phys. Rev. C 17, 163 (1978), 10.1103/PhysRevC.17.163], Gindler et al. [Phys. Rev. C 27, 2058 (1983), 10.1103/PhysRevC.27.2058], and those of Mac Innes et al. [Nucl. Data Sheets 112, 3135 (2011), 10.1016/j.nds.2011.11.009] and Laurec et al. [Nucl. Data Sheets 111, 2965 (2010), 10.1016/j.nds.2010.11.004] at 14.5 and 14.7 MeV, respectively. This comparison indicates a negative slope for the energy dependence of most fission product yields obtained from 235U and 239Pu , whereas for 238U the slope issue remains unsettled.

  17. The role of crumbs genes in the vertebrate cornea.

    PubMed

    Beyer, Jill; Zhao, Xinping C; Yee, Richard; Khaliq, Shagufta; McMahon, Timothy T; Ying, Hongyu; Yue, Beatrice Y J T; Malicki, Jarema J

    2010-09-01

    To evaluate the role of crumbs genes and related epithelial polarity loci in the vertebrate cornea. The authors used histologic analysis and electron microscopy to evaluate the corneas of zebrafish mutant for a crumbs locus oko meduzy (ome) and in mutants of four other loci, nagie oko (nok), heart and soul (has), mosaic eyes (moe), and ncad (formerly glass onion), that function in the same or related genetic pathways. In parallel, they performed an evaluation of corneas in human carriers of a crumbs gene, CRB1, and mutations using topography and biomicroscopy. The expression of the CRB1 gene in the normal human cornea was examined by polymerase chain reaction (PCR) and immunohistochemical staining. The corneas of zebrafish mutants display severe abnormalities of the epithelial and stromal layers. The epithelial cells do not properly adhere to each other, and fluid-filled spaces form between them. In addition, the layering of the corneal stroma is poorly formed or absent. The corneas of human carriers of CRB1 mutations display shape deviations compared with what has been observed in normal individuals. A PCR product of the correct size was obtained from normal human corneal samples. Sequence analyses confirmed its identity to be the human CRB1 gene. Immunohistochemical staining using anti-CRB1 yielded positive brown deposits in the human cornea. crumbs genes play a role in the differentiation of the vertebrate cornea. Corneal defects associated with crumbs gene mutations are very severe in the zebrafish model and, in comparison, appear clinically less pronounced in the human eye.

  18. κ-Casein terminates casein micelle build-up by its "soft" secondary structure.

    PubMed

    Nagy, Krisztina; Váró, György; Szalontai, Balázs

    2012-11-01

    In our previous paper (Nagy et al. in J Biol Chem 285:38811-38817, 2010) by using a multilayered model system, we showed that, from α-casein, aggregates (similar to natural casein micelles) can be built up step by step if Ca-phosphate nanocluster incorporation is ensured between the protein adsorption steps. It remained, however, an open question whether the growth of the aggregates can be terminated, similarly to in nature with casein micelles. Here, we show that, in the presence of Ca-phosphate nanoclusters, upon adsorbing onto earlier α-casein surfaces, the secondary structure of α-casein remains practically unaffected, but κ-casein exhibits considerable changes in its secondary structure as manifested by a shift toward having more β-structures. In the absence of Ca-phosphate, only κ-casein can still adsorb onto the underlying casein surface; this κ-casein also expresses considerable shift toward β-structures. In addition, this κ-casein cover terminates casein aggregation; no further adsorption of either α- or κ-casein can be achieved. These results, while obtained on a model system, may show that the Ca-insensitive κ-casein can, indeed, be the outer layer of the casein micelles, not only because of its "hairy" extrusion into the water phase, but because of its "softer" secondary structure, which can "occlude" the interacting motifs serving casein aggregation. We think that the revealed nature of the molecular interactions, and the growth mechanism found here, might be useful to understand the aggregation process of casein micelles also in vivo.

  19. The Child and the Fear of Death

    PubMed Central

    Mitchell, Nelli L.; Schulman, Karen R.

    1981-01-01

    The central hypothesis of this paper is that the innate fear of death in the human being is universal and that the child, least of all, is immune to death fear and its symbolic representation. This cuts across all ages and developmental levels. This paper is not concerned with the empirical knowledge of death, an area that has been extensively explored by others such as Nagy (1948), Piaget (1929), and Anthony (1940). Examination of the child and his relationship to death is important in order to reach the truth and understand the human meaning of the fear of death. The child's conception of himself and his relationship to the world is an ironic paradox. On one hand, he feels endowed with magical feelings of omnipotence. This feeling is the main defense against the fear of death. On the other hand, his wishes, both benevolent and malevolent, have power independent of him to influence events. The concept of chance is alien, and the differentiation between objective and wishful causation is obscured. Thus, the way in which the child perceives his world makes the terror of death more formidable. Several conclusions are reached in this paper: (1) that even in childhood, loss, endings, separations, and death are core concerns of the individual; (2) that fear of death in children is intensified by the absence of the intellectual equipment and the absence of the necessary defense mechanisms essential for comprehending the experience of loss; and (3) that repression of the fear of death is an evolutionary process which has its origin in childhood. PMID:7310912

  20. Aesthetics and representation in holography

    NASA Astrophysics Data System (ADS)

    Kac, Eduardo

    1995-02-01

    Every medium has a code, a set of rules or conventions according to which determined elements are organized into a signifying system. The English language is a code as is perspective in painting and photography. In the first case, the elements are phonemes organized into words and sentences according to a social convention: the syntax of English. In the second case, the elements are dots and lines organized into pictures according to a geometric method. An artist or movement can break the conventions of the medium, as has done Cezanne with painting, Moholy-Nagy with photography and cummings with the English idiom in poetry, and create new elements and rules for combining them. If this is done, the level of predictability (or conventionality) is lowered and unpredictability is increased -- becoming more difficult for the immediate audience to understand it. But once these new rules are learned and the ideas behind them widely understood, the level of unpredictability is lowered and they become new conventions that can be accepted by the audience. Holographic artists exploring the medium -- as opposed to advertisers using holography, who favor a high level of predictability -- are breaking several visual and cultural conventions. As a matter of fact, holography is so new that many questions are left open about the nature of the medium. Therefore, any attempt to clarify the issues raised by holography on a cultural level has a prospective (and not conclusive) tone, concentrating more thoroughly on general points and on the promise of its potentialities than on the records of its historical achievements so far.

  1. Ensemble density variational methods with self- and ghost-interaction-corrected functionals

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Pastorczak, Ewa; Pernal, Katarzyna, E-mail: pernalk@gmail.com

    2014-05-14

    Ensemble density functional theory (DFT) offers a way of predicting excited-states energies of atomic and molecular systems without referring to a density response function. Despite a significant theoretical work, practical applications of the proposed approximations have been scarce and they do not allow for a fair judgement of the potential usefulness of ensemble DFT with available functionals. In the paper, we investigate two forms of ensemble density functionals formulated within ensemble DFT framework: the Gross, Oliveira, and Kohn (GOK) functional proposed by Gross et al. [Phys. Rev. A 37, 2809 (1988)] alongside the orbital-dependent eDFT form of the functional introducedmore » by Nagy [J. Phys. B 34, 2363 (2001)] (the acronym eDFT proposed in analogy to eHF – ensemble Hartree-Fock method). Local and semi-local ground-state density functionals are employed in both approaches. Approximate ensemble density functionals contain not only spurious self-interaction but also the so-called ghost-interaction which has no counterpart in the ground-state DFT. We propose how to correct the GOK functional for both kinds of interactions in approximations that go beyond the exact-exchange functional. Numerical applications lead to a conclusion that functionals free of the ghost-interaction by construction, i.e., eDFT, yield much more reliable results than approximate self- and ghost-interaction-corrected GOK functional. Additionally, local density functional corrected for self-interaction employed in the eDFT framework yields excitations energies of the accuracy comparable to that of the uncorrected semi-local eDFT functional.« less

  2. Loss of Different Inverted Repeat Copies from the Chloroplast Genomes of Pinaceae and Cupressophytes and Influence of Heterotachy on the Evaluation of Gymnosperm Phylogeny

    PubMed Central

    Wu, Chung-Shien; Wang, Ya-Nan; Hsu, Chi-Yao; Chaw, Shu-Miaw

    2011-01-01

    The relationships among the extant five gymnosperm groups—gnetophytes, Pinaceae, non-Pinaceae conifers (cupressophytes), Ginkgo, and cycads—remain equivocal. To clarify this issue, we sequenced the chloroplast genomes (cpDNAs) from two cupressophytes, Cephalotaxus wilsoniana and Taiwania cryptomerioides, and 53 common chloroplast protein-coding genes from another three cupressophytes, Agathis dammara, Nageia nagi, and Sciadopitys verticillata, and a non-Cycadaceae cycad, Bowenia serrulata. Comparative analyses of 11 conifer cpDNAs revealed that Pinaceae and cupressophytes each lost a different copy of inverted repeats (IRs), which contrasts with the view that the same IR has been lost in all conifers. Based on our structural finding, the character of an IR loss no longer conflicts with the “gnepines” hypothesis (gnetophytes sister to Pinaceae). Chloroplast phylogenomic analyses of amino acid sequences recovered incongruent topologies using different tree-building methods; however, we demonstrated that high heterotachous genes (genes that have highly different rates in different lineages) contributed to the long-branch attraction (LBA) artifact, resulting in incongruence of phylogenomic estimates. Additionally, amino acid compositions appear more heterogeneous in high than low heterotachous genes among the five gymnosperm groups. Removal of high heterotachous genes alleviated the LBA artifact and yielded congruent and robust tree topologies in which gnetophytes and Pinaceae formed a sister clade to cupressophytes (the gnepines hypothesis) and Ginkgo clustered with cycads. Adding more cupressophyte taxa could not improve the accuracy of chloroplast phylogenomics for the five gymnosperm groups. In contrast, removal of high heterotachous genes from data sets is simple and can increase confidence in evaluating the phylogeny of gymnosperms. PMID:21933779

  3. Loss of different inverted repeat copies from the chloroplast genomes of Pinaceae and cupressophytes and influence of heterotachy on the evaluation of gymnosperm phylogeny.

    PubMed

    Wu, Chung-Shien; Wang, Ya-Nan; Hsu, Chi-Yao; Lin, Ching-Ping; Chaw, Shu-Miaw

    2011-01-01

    The relationships among the extant five gymnosperm groups--gnetophytes, Pinaceae, non-Pinaceae conifers (cupressophytes), Ginkgo, and cycads--remain equivocal. To clarify this issue, we sequenced the chloroplast genomes (cpDNAs) from two cupressophytes, Cephalotaxus wilsoniana and Taiwania cryptomerioides, and 53 common chloroplast protein-coding genes from another three cupressophytes, Agathis dammara, Nageia nagi, and Sciadopitys verticillata, and a non-Cycadaceae cycad, Bowenia serrulata. Comparative analyses of 11 conifer cpDNAs revealed that Pinaceae and cupressophytes each lost a different copy of inverted repeats (IRs), which contrasts with the view that the same IR has been lost in all conifers. Based on our structural finding, the character of an IR loss no longer conflicts with the "gnepines" hypothesis (gnetophytes sister to Pinaceae). Chloroplast phylogenomic analyses of amino acid sequences recovered incongruent topologies using different tree-building methods; however, we demonstrated that high heterotachous genes (genes that have highly different rates in different lineages) contributed to the long-branch attraction (LBA) artifact, resulting in incongruence of phylogenomic estimates. Additionally, amino acid compositions appear more heterogeneous in high than low heterotachous genes among the five gymnosperm groups. Removal of high heterotachous genes alleviated the LBA artifact and yielded congruent and robust tree topologies in which gnetophytes and Pinaceae formed a sister clade to cupressophytes (the gnepines hypothesis) and Ginkgo clustered with cycads. Adding more cupressophyte taxa could not improve the accuracy of chloroplast phylogenomics for the five gymnosperm groups. In contrast, removal of high heterotachous genes from data sets is simple and can increase confidence in evaluating the phylogeny of gymnosperms.

  4. Highly rearranged and size-variable chloroplast genomes in conifers II clade (cupressophytes): evolution towards shorter intergenic spacers.

    PubMed

    Wu, Chung-Shien; Chaw, Shu-Miaw

    2014-04-01

    Although conifers are of immense ecological and economic value, bioengineering of their chloroplasts remains undeveloped. Understanding the chloroplast genomic organization of conifers can facilitate their bioengineering. Members of the conifer II clade (or cupressophytes) are highly diverse in both morphologic features and chloroplast genomic organization. We compared six cupressophyte chloroplast genomes (cpDNAs) that represent four of the five cupressophyte families, including three genomes that are first reported here (Agathis dammara, Calocedrus formosana and Nageia nagi). The six cupressophyte cpDNAs have lost a pair of large inverted repeats (IRs) and vary greatly in size, organization and tRNA copies. We demonstrate that cupressophyte cpDNAs have evolved towards reduced size, largely due to shrunken intergenic spacers. In cupressophytes, cpDNA rearrangements are capable of extending intergenic spacers, and synonymous mutations are negatively associated with the size and frequency of rearrangements. The variable cpDNA sizes of cupressophytes may have been shaped by mutational burden and genomic rearrangements. On the basis of cpDNA organization, our analyses revealed that in gymnosperms, cpDNA rearrangements are phylogenetically informative, which supports the 'gnepines' clade. In addition, removal of a specific IR influences the minimal rearrangements required for the gnepines and cupressophyte clades, whereby Pinaceae favours the removal of IRB but cupressophytes exclusion of IRA. This result strongly suggests that different IR copies have been lost from conifers I and II. Our data help understand the complexity and evolution of cupressophyte cpDNAs. © 2013 The Authors. Plant Biotechnology Journal published by Society for Experimental Biology, The Association of Applied Biologists and John Wiley & Sons Ltd.

  5. Loss of Regulatory Protein RfaH Attenuates Virulence of Uropathogenic Escherichia coli

    PubMed Central

    Nagy, Gábor; Dobrindt, Ulrich; Schneider, György; Khan, A. Salam; Hacker, Jörg; Emödy, Levente

    2002-01-01

    RfaH is a regulatory protein in Escherichia coli and Salmonella enterica serovar Typhimurium. Although it enhances expression of different factors that are proposed to play a role in bacterial virulence, a direct effect of RfaH on virulence has not been investigated so far. We report that inactivation of rfaH dramatically decreases the virulence of uropathogenic E. coli strain 536 in an ascending mouse model of urinary tract infection. The mortality rate caused by the wild-type strain in this assay is 100%, whereas that of its isogenic rfaH mutant does not exceed 18%. In the case of coinfection, the wild-type strain 536 shows higher potential to colonize the urinary tract even when it is outnumbered 100-fold by its rfaH mutant in the inoculum. In contrast to the wild-type strain, serum resistance of strain 536rfaH::cat is fully abolished. Furthermore, we give evidence that, besides a major decrease in the amount of hemin receptor ChuA (G. Nagy, U. Dobrindt, M. Kupfer, L. Emody, H. Karch, and J. Hacker, Infect. Immun. 69:1924-1928, 2001), loss of the RfaH protein results in an altered lipopolysaccharide phenotype as well as decreased expression of K15 capsule and alpha-hemolysin, whereas levels of other pathogenicity factors such as siderophores, flagella, Prf, and S fimbriae appear to be unaltered in strain 536rfaH::cat in comparison to the wild-type strain. trans complementation of the mutant strain with the rfaH gene restores wild-type levels of the affected virulence factors and consequently restitutes virulence in the mouse model of ascending urinary tract infection. PMID:12117951

  6. Ultrasonic Nondestructive Characterization of Adhesive Bonds

    NASA Technical Reports Server (NTRS)

    Qu, Jianmin

    1997-01-01

    Qualitative measurements of adhesion or binding forces can be accomplished, for example, by using the reflection coefficient of an ultrasound or by using thermal waves (Light and Kwun, 1989, Achenbach and Parikh, 1991, and Bostrom and wickham, 1991). However, a quantitative determination of binding forces is rather difficult. It has been observed that higher harmonics of the fundamental frequency are generated when an ultrasound passes through a nonlinear material. It seems that such non-linearity can be effectively used to characterize the bond strength. Several theories have been developed to model this nonlinear effect (Adler and Nagy, 1991; Achenbach and Parikh, 1991; Parikh and Achenbach, 1992; and Hirose and Kitahara, 1992; Anastasi and Roberts, 1992). Based on a microscopic description of the nonlinear interface binding force, a quantitative method was presented by Pangraz and Arnold (1994). Recently, Tang, Cheng and Achenbach (1997) made a comparison between the experimental and simulated results based on this theoretical model. A water immersion mode-converted shear wave through-transmission setup was used by Berndt and Green (1997) to analyze the nonlinear acoustic behavior of the adhesive bond. In this project, the nonlinear responses of an adhesive joint was investigated through transmission tests of ultrasonic wave and analyzed by the finite element simulations. The higher order harmonics were obtained in the tests. It is found that the amplitude of higher harmonics increases as the aging increases, especially the 3dorder harmonics. Results from the numerical simulation show that the material nonlinearity does indeed generate higher order harmonics. In particular, the elastic-perfect plastic behavior generates significant 3rd and 5th order harmonics.

  7. Non-Euclidean Space, Movement and Astronomy in Modern Art: Alexander Calder's Mobiles and Ben Nicholson's Reliefs

    NASA Astrophysics Data System (ADS)

    Malloy, Vanja

    2013-09-01

    John Keats once wrote that `there is no such thing as time and space' rather, believing that time and space are mental constructs that are subject to a variety of forms and as diverse as the human mind. In the 1920s through the 1930s, modern physics in many ways supported this idea through the various philosophical writings on the Theory of General Relativity to the masses by scientists such as Arthur Eddington and Albert Einstein. These new concepts of modern physics fundamentally changed our understanding of time and space and had substantial philosophical implications, which were absorbed by modern artists resulting in the 1936 Dimensionist Manifesto. Seeking to internalize the developments of modern science within modern art, this manifesto was widely endorsed by the most prominent figures of the avant-garde such as Marcel Duchamp, Jean Arp, Naum Gabo, Joan Miró, László Moholy-Nagy, Wassily Kandinsky and Alexander Calder. Of particular interest to this manifesto was the new concept of the fourth-dimension, which in many ways revolutionized the arts. Importantly, its interpretation varied widely in the artistic community, ranging from a purely physical four-dimensional space, to a kinetic concept of space in which space and time are linked, to a metaphysical interest in a space that exists beyond the material realm. The impact of modern science and astronomy on avant-garde art is currently a bourgeoning area of research with considerable implications to our rethinking of substantial artistic figures of this era. Through a case study of Alexander Calder's Mobiles and Ben Nicholson's Reliefs, this paper explores how these artworks were informed by an interest in modern science.

  8. PREFACE: International Conference on the Applications of the Mössbauer Effect (ICAME 2009)

    NASA Astrophysics Data System (ADS)

    Müller, Herbert; Reissner, Michael; Steiner, Walter; Wiesinger, Günter

    2010-04-01

    . The positive atmosphere, the high attendance in the sessions and the lively discussions made the conference a great success and a memorable event. It was pointed out, that Mössbauer spectroscopy is still an interesting and powerful method with great opportunities in the future. Herbert Müller (Secretary) Michael Reissner (Chairman) This book is dedicated to our colleagues Nicol Malcom, who could not come, because he suddenly died a few weeks in advance to the conference and Hercilio Rechenberg, who died on his way home from Vienna. Conference photograph Conference Organisation Local Organizing Committee Reissner Michael (Chairman)Müller Herbert (Conference Secretary) Amthauer Georg Lottermoser WernerSteiner Walter Bauer Ernst Michor Herwig Vogl Gero Bühler-Paschen Silke Müller Martin Waas Monika Grodzicki Michael Redhammer Günther Wiesinger Günter Grössinger Roland Sassik Herbert Hilscher Gerfried Sepiol Bogdan International Programme Committee Amthauer Georg Gütlich Philipp Steiner Walter Baggio-Saitovich Elisa Litterst Fred Jochen Trautwein Alfred Xaver Berry Frank Long Gary Vogl Gero Felner Israel Nagy Denes Lajos Yoshida Yutaka Greneche Jean-Marc Rüffer Rudolf International Advisory Board Alp E ErcanGénin Jean-Marie Baggio-Saitovitch Elisa Greneche Jean-Marc Miglierini Marcel Balogh Judit Grodzicki Michael Musić Svetozar Bender Koch Christian Gütlich Philipp Nagy Dénes Lajos Berry Frank Häggström Lennart Nishida Tetsuaki Brown Dennis Hanzel Darko Pérez Alcázar German Campbell Stewart Hassaan Mohamed Yousri Rüffer Rudolf Carbucicchio Massimo Jumas Jean-Claude Ryan Dominic H Croci Simonetta Kadyrzhanov Kariat Sanchez Francisco Di Naili Katila Toivo Schünemann Volker Elzain Mohamed Kim Chul Sung Stanek Jan Fabris José Domingos Klingelhöfer Göstar Stevens John Felner Israel Langouche Guido Suzdalev Igor P Fern George R Lyubutin Igor S Szymanski Krzysztof Forder Sue D Marco Jose F Waanders Frans Gajbhiye Nandeo Mašlaň Miroslav Yoshida Yutaka

  9. Co-ordination of physiological and morphological responses of stomata to elevated [CO2] in vascular plants.

    PubMed

    Haworth, Matthew; Elliott-Kingston, Caroline; McElwain, Jennifer C

    2013-01-01

    Plant stomata display a wide range of short-term behavioural and long-term morphological responses to atmospheric carbon dioxide concentration ([CO(2)]). The diversity of responses suggests that plants may have different strategies for controlling gas exchange, yet it is not known whether these strategies are co-ordinated in some way. Here, we test the hypothesis that there is co-ordination of physiological (via aperture change) and morphological (via stomatal density change) control of gas exchange by plants. We examined the response of stomatal conductance (G(s)) to instantaneous changes in external [CO(2)] (C(a)) in an evolutionary cross-section of vascular plants grown in atmospheres of elevated [CO(2)] (1,500 ppm) and sub-ambient [O(2)] (13.0 %) compared to control conditions (380 ppm CO(2), 20.9 % O(2)). We found that active control of stomatal aperture to [CO(2)] above current ambient levels was not restricted to angiosperms, occurring in the gymnosperms Lepidozamia peroffskyana and Nageia nagi. The angiosperm species analysed appeared to possess a greater respiratory demand for stomatal movement than gymnosperm species displaying active stomatal control. Those species with little or no control of stomatal aperture (termed passive) to C(a) were more likely to exhibit a reduction in stomatal density than species with active stomatal control when grown in atmospheres of elevated [CO(2)]. The relationship between the degree of stomatal aperture control to C(a) above ambient and the extent of any reduction in stomatal density may suggest the co-ordination of physiological and morphological responses of stomata to [CO(2)] in the optimisation of water use efficiency. This trade-off between stomatal control strategies may have developed due to selective pressures exerted by the costs associated with passive and active stomatal control.

  10. Human Cytochrome P450 21A2, the Major Steroid 21-Hydroxylase

    PubMed Central

    Pallan, Pradeep S.; Wang, Chunxue; Lei, Li; Yoshimoto, Francis K.; Auchus, Richard J.; Waterman, Michael R.; Guengerich, F. Peter; Egli, Martin

    2015-01-01

    Cytochrome P450 (P450) 21A2 is the major steroid 21-hydroxylase, and deficiency of this enzyme is involved in ∼95% of cases of human congenital adrenal hyperplasia, a disorder of adrenal steroidogenesis. A structure of the bovine enzyme that we published previously (Zhao, B., Lei, L., Kagawa, N., Sundaramoorthy, M., Banerjee, S., Nagy, L. D., Guengerich, F. P., and Waterman, M. R. (2012) Three-dimensional structure of steroid 21-hydroxylase (cytochrome P450 21A2) with two substrates reveals locations of disease-associated variants. J. Biol. Chem. 287, 10613–10622), containing two molecules of the substrate 17α-hydroxyprogesterone, has been used as a template for understanding genetic deficiencies. We have now obtained a crystal structure of human P450 21A2 in complex with progesterone, a substrate in adrenal 21-hydroxylation. Substrate binding and release were fast for human P450 21A2 with both substrates, and pre-steady-state kinetics showed a partial burst but only with progesterone as substrate and not 17α-hydroxyprogesterone. High intermolecular non-competitive kinetic deuterium isotope effects on both kcat and kcat/Km, from 5 to 11, were observed with both substrates, indicative of rate-limiting C–H bond cleavage and suggesting that the juxtaposition of the C21 carbon in the active site is critical for efficient oxidation. The estimated rate of binding of the substrate progesterone (kon 2.4 × 107 m−1 s−1) is only ∼2-fold greater than the catalytic efficiency (kcat/Km = 1.3 × 107 m−1 s−1) with this substrate, suggesting that the rate of substrate binding may also be partially rate-limiting. The structure of the human P450 21A2-substrate complex provides direct insight into mechanistic effects of genetic variants. PMID:25855791

  11. Study of Surface Wave Propagation in Fluid-Saturated Porous Solids.

    NASA Astrophysics Data System (ADS)

    Azcuaga, Valery Francisco Godinez

    1995-01-01

    This study addresses the surface wave propagation phenomena on fluid-saturated porous solids. The analytical method for calculation of surface wave velocities (Feng and Johnson, JASA, 74, 906, 1983) is extended to the case of a porous solid saturated with a wetting fluid in contact with a non-wetting fluid, in order to study a material combination suitable for experimental investigation. The analytical method is further extended to the case of a non-wetting fluid/wetting fluid-saturated porous solid interface with an arbitrary finite surface stiffness. These extensions of the analytical method allows to theoretically study surface wave propagation phenomena during the saturation process. A modification to the 2-D space-time reflection Green's function (Feng and Johnson, JASA, 74, 915, 1983) is introduced in order to simulate the behavior of surface wave signals detected during the experimental investigation of surface wave propagation on fluid-saturated porous solids (Nagy, Appl. Phys. Lett., 60, 2735, 1992). This modification, together with the introduction of an excess attenuation for the Rayleigh surface mode, makes it possible to explain the apparent velocity changes observed on the surface wave signals during saturation. Experimental results concerning the propagation of surface waves on an alcohol-saturated porous glass are presented. These experiments were performed at frequencies of 500 and 800 kHz and show the simultaneous propagation of the two surface modes predicted by the extended analytical method. Finally an analysis of the displacements associated with the different surface modes is presented. This analysis reveals that it is possible to favor the generation of the Rayleigh surface mode or of the slow surface mode, simply by changing the type of transducer used in the generation of surface waves. Calculations show that a shear transducer couples more energy into the Rayleigh mode, whereas a longitudinal transducer couples more energy into the slow

  12. The European Micropaleontological Reference Centre in Kraków

    NASA Astrophysics Data System (ADS)

    Kaminski, Michael; Waskowska, Anna; Bebenek, Slawomir; Pilarz, Monika

    2016-04-01

    We are pleased to announce the establishment of the European Micropaleontological Reference Centre, housed in the offices of Micropress Europe at the AGH University of Science & Technology in Krakow, Poland. The new European Micropaleontological Reference Centre is an initiative of the Grzybowski Foundation and Micropress Europe. The centre is designed to serve the micropaleontological community by providing a permanent repository or "museum" for published microfossil collections. The centre houses a growing collection of microfossils picked into faunal slides, as well as a well-stocked library of micropaleontological books, journals, and reprints. We have the only up-to-date paper copy of the Ellis & Messina Catalogue of Foraminifera in Central Europe. Currently, the slide collections include: - Type slides of benthic foraminifera from Poland (the collection of I. Heller from the Polish oil company GEONAFTA), - Carboniferous foraminifera from Germany and Poland (collections of G. Eickhoff and Z. Alexandrowicz), - IODP sites in the Arctic, Atlantic, and Indian Oceans (collections of M. Kaminski, E. Setoyama, A. Holborn), - Exploration wells in the Boreal seas: North Sea, Norwegian Sea, Western Barents Sea, Labrador Sea, Bering Sea, Spitsbergen, Western Siberia (collections of M. Kaminski, J. Nagy, T. Van Den Akker, V. Podobina, and others), - Paratethyan Foraminifera (collections of E. Luczkowska, C. Beldean, F. Szekely), - Mesozoic-Paleogene Foraminifera from Gubbio, Italy (collections of M. Kaminski, C. Cetean, and students) and the Polish Carpathians (collection of A. Waskowska), - Caribbean (collection of M. Kaminski, R. Preece), West Africa (collection of R. Preece, S. Kender, C. Cetean), - We have a separate collection of type specimens of species (paratypes). Slides are housed in cabinet drawers together with the relevant publication. Researchers are welcome to visit the offices of Micropress Europe to view the archived microfossil collections. The center

  13. Flowstone compositions as indicators of centennial fluctuations of hydrological balance in Central Europe during the late Holocene

    NASA Astrophysics Data System (ADS)

    Demény, Attila; Kern, Zoltán; Molnár, Mihály; Czuppon, György; Leél-Őssy, Szabolcs; Surányi, Gergely; Gilli, Adrian

    2017-04-01

    Flowstones formed from springs in the Baradla and Béke Caves, North-east Hungary were drilled at several locations, and their sites were monitored for temperature, CO2 level in cave air, water and carbonate compositions for three years. The monitoring results suggest that the carbonate precipitated close to equilibrium with the local water. The non-systematic distribution of stable isotope and chemical compositions along sections on the surfaces of flowstone occurrences indicate irregular formation and the possibility of hiatuses within the flowstones' edifices. Approximately 40 cm long drill cores were extracted from the „Nagy-tufa" flowstone of the Béke Cave (BNT-2 core) and the Havasok flowstone of the Baradla Cave. U-Th dating efforts resulted in very large age uncertainties for the BNT-2 core, owing to detrital Th contamination. Therefore, in addition to the U-Th dating, AMS radiocarbon analyses were conducted to establish reliable age-depth models. The raw 14C ages were corrected for the dead carbon fraction (dfc) using radiocarbon results obtained for samples that yielded also accurate U-Th ages. Calibration and age-depth modeling have been performed using the OxCal v4.2.4. software. The data prove that the flowstones in the studied caves were formed contemporarily, covering the last 4 ka with two major hiatuses around 3.5 and 1 ka BP. Inclusion-hosted water contents, stable carbon and oxygen isotope compositions of carbonate, and hydrogen isotope composition of inclusion-hosted water as well as Si contents were determined for the two cores and compared with regional paleoclimate records for the period of 3.5 to 1 ka BP. The water contents, δ13Ccarb values and Si contents show correspondence with paleoprecipitation proxies from Central Europe to western Anatolia, while the paleotemperature estimates obtained using the δDwater values were in agreement with temperature reconstructions derived from paleobiological proxies from nearby lake sediments. The

  14. COLLOID-FACILITATED TRANSPORT OF RADIONUCLIDES THROUGH THE VADOSE ZONE

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Flury, Markus

    2003-09-14

    project has close relations to the following EMSP projects: Project: 70126, Interfacial Soil Chemistry of Radionuclides in the Unsaturated Zone (PI: Jon Chorover) Project: 70070, Reactivity of Primary Soil Minerals and Secondary Precipitates (PI: Kathy Nagy) Cesium Transport in Hanford Sediments: Application of an Experimentally Based Cation Exchange Model (PI: Susan Carroll and Carl Steefel).« less

  15. Dependence of the location of the Martian magnetic lobes on the interplanetary magnetic field direction

    NASA Astrophysics Data System (ADS)

    Romanelli, Norberto; Mazelle, Christian; Bertucci, Cesar; Gomez, Daniel

    2016-04-01

    The magnetic field topology surrounding the Martian atmosphere is mainly the result of gradients in the velocity of the solar wind (SW). Such variations in the SW velocity are in turn the result of a massloading process and forces associated with electric currents flowing around the ionosphere of Mars [Nagy et al 2004, Mazelle et al 2004, Brain et al 2015]. In particular, in the regions where the collisionless regime holds, the interplanetary magnetic field (IMF) frozen into the SW piles up in front of the stagnation region of the flow. At the same time, the magnetic field lines are stretched in the direction of the unperturbed SW as this stream moves away from Mars, giving rise to a magnetotail [Alfvén, 1957]. As a result and in contrast with an obstacle with and intrinsic global magnetic field, the structure and organization of the magnetic field around Mars depends on the direction of the IMF and its variabilities [Yeroshenko et al., 1990; Crider et al., 2004; Bertucci et al., 2003; Romanelli et al 2015]. In this study we use magnetometer data from the Mars Global Surveyor (MGS) spacecraft during portions of the premapping orbits of the mission to study the variability of the Martian-induced magnetotail as a function of the orientation of the IMF. The time spent by MGS in the magnetotail lobes during periods with positive solar wind flow-aligned IMF component B∥IMF suggests that their location as well as the position of the central polarity reversal layer (PRL) are displaced in the direction antiparallel to the IMF cross-flow component B⊥IMF . Analogously, in the cases where B∥IMF is negative, the lobes are displaced in the direction of B⊥IMF. We find this behavior to be compatible with a previously published B⊥IMF analytical model of the IMF draping, where for the first time, the displacement of a complementary reversal layer (denoted as IPRL for inverse polarity reversal layer) is deduced from first principles [Romanelli et al 2014]. We also

  16. Proceedings of the Ringberg Workshop New Trends in HERA Physics 2005

    NASA Astrophysics Data System (ADS)

    Grindhammer, G.; Ochs, W.; Kniehl, B. A.; Kramer, G.

    2006-04-01

    1. Proton structure. Proton structure measurements at high Q2 and large x / Katarzyna Wichmann. Electroweak physics at HERA / Joachim Meyer. Inclusive low Q2 measurements at HERA / Victor Lendermann. Resummed perturbative evolution at high energy / Richard Ball. Colour dipole phenomenology / Graham Shaw -- 2. Spin physics. Exclusive reactions at HERMES / Frank Ellinghaus. Transverse spin effects in single and double hadron electroproduction at HERMES / Benedikt Zihlmann. Present understanding of the nucleon spin structure in view of recent experiments / Andreas Metz -- 3. Production of Hadrons and Jets. Measurements of [symbol] and parton distribution functions using HERA jet data / Amanda Cooper-Sarkar. A new parton shower algorithm: shower evolution, matching at leading and next-to-leading order level / Zóltan Nagy. Jet production at HERA / Dan Traynor. Multi-jet production in lepton-proton scattering with next-to-leading order accuracy / Zóltan Trócsányi. Dijet rates with symmetric [symbol] cuts / Andrea Banfi. QCD dynamics from forward hadron and jet measurements / Lidia Goerlich. Light-hadron electroproduction at next-to-leading order and implications / Bernd Kniehl. Particle production and fragmentation / David Saxon. Soft gluon logarithmic resummation and hadron mass effects in single hadron inclusive production / Simon Albino -- 4. Heavy-flavour production. Heavy-flavour photo- and electroproduction at NLO / Ingo Schienbein. Physics with charm quarks at HERA / John Loizides. Beauty production at HERA / Olaf Behnke. J/[symbol] photoproduction at next-to-leading order / Luminita Mihaila. J/[symbol] photoproduction at large z in soft collinear effective theory / Sean Fleming -- 5. Diffractive ep Scattering. Exclusive and inclusive diffraction at HERA / Henri Kowalski. Diffractive production of vector mesons and the gluon at small x / Thomas Teubner. Inclusive diffraction / Laurent Favart. From factorization to its breaking in diffractive dijet production

  17. Lava dome morphometry and geochronology of the youngest eruptive activity in Eastern Central Europe: Ciomadul (Csomád), East Carpathians, Romania

    NASA Astrophysics Data System (ADS)

    Karátson, D.; Telbisz, T.; Harangi, Sz.; Magyari, E.; Kiss, B.; Dunkl, I.; Veres, D.; Braun, M.

    2012-04-01

    Volcanic evolution of the Ciomadul (Csomád) lava dome complex, site of the youngest (Late Pleistocene, late Marine Isotope Stage 3) eruptive activity in the Carpathians, has been studied by advanced morphometry and radiometric (U/Pb, U/He and 14C) geochronology. The volcano produced alternating effusive and intermittent explosive eruptions from individual domes, typical of common andesitic-dacitic lava domes. A comparative morphometry shows steep ≥30° mean slopes of domes' upper flank and the Csomád domes fit well to the 100-200 ka domes worldwide. Morphometric ages obtained from the mean slope vs age precipitation correlation results in ≤100 ka ages. The morphometric approach is supported by U/Pb and U/He chronology: preliminary results of zircon dating indicate ages ranging between 200(250) and 30 ka. The youngest ages of the data set obtained both from lavas and pumiceous pyroclastics argue for a more or less coeval effusive and explosive volcanism. Based also on volcanological data, we propose vulcanian eruptions and explosive dome collapses especially toward the end of volcanic activity. Moreover, radiometric chronology suggests that, possibly subsequently to the peripheral domes, a central lava dome complex built up ≤100 ka ago. This dome complex, exhibiting even more violent, up to sub-plinian explosions, emplaced pumiceous pyroclastic flow and fall deposits as far as 17 km. We propose that the explosive activity produced caldera-forming eruptions as well, creating a half-caldera. This caldera rim is manifested by the asymmetric morphology of the central edifice: the present-day elevated ridge of Ciomadul Mare (Nagy Csomád), encompassing the twin craters of Mohoş (Mohos) peat bog and Sf. Ana (Szent [St.] Anna). These latter craters may have been formed subsequently, ca. ~100-30 ka ago, after the caldera formation. Drilling of lacustrine sediments in the St. Anna crater shows that beneath the Holocene gyttja several meters of Late Pleistocene

  18. Integrated Geophysical Survey on Deák Ferenc Sluice in Hungary

    NASA Astrophysics Data System (ADS)

    Kanli, A. I.

    2015-12-01

    ALI ISMET KANLI1*, G. TALLER2, Z. PRONAY2, P. TILDY2, P. NAGY3, E. TOROS2 *1Istanbul University, Turkey, kanli@istanbul.edu.tr, 2Geological and Geophysical Institute of Hungary,3MinGeo, Hungary The Ferenc Channel is one of the main irrigation and ship channel in south of Hungary, existing from 1801. The water level is controlled by the Deák Ferenc Sluice in the channel which was constructed in 1875. At that time, the sluice was unique in Europe with its two channels and brick-walls. The west channel was used for controlling the amount of water and the east channel was used for shipping. In the study, before starting to the restoration and reinforcement plannings at the sluice, non-destructive geophysical investigations were executed. In the first stage, ultra-high frequency seismic (80 kHz) and acoustic (5 kHz) investigations of the floor slab were carried out from a boat on the water level. Due to the water level was approximately 2 m, we could use the advantage of the water ensuring very good coupling with seismic sensors for high frequency seismic and acoustic measurements. In the second stage, resistivity measurements were carried out in the eastern part of the sluice which was used as the shipping channel. Three profiles were measured to map the resistivity distribution of the slab. In the third stage, for better understanding the stability conditions of the walls and easy to compare with the data of GPR measurements, the wall of the sluice were investigated by a simple seismic direct wave method using seismic P-waves for mapping seismic velocities. The last stage of the survey was the GPR measurements that were carried out both on the walls and on the slab of the sluice. During the investigation, the channels were empty and without water. The integrated survey and the interpretation of the results showed us that there were some faults, cracks and voids in the slab existed in the whole grossness of the slab and the brick walls were builded from inhomogenous

  19. The Orgueil meteorite: 150 years of history

    NASA Astrophysics Data System (ADS)

    Gounelle, Matthieu; Zolensky, Michael E.

    2014-10-01

    The goal of this paper is to summarize 150 yr of history of a very special meteorite. The Orgueil meteorite fell near Montauban in southwestern France on May 14, 1864. The bolide, which was the size of the full Moon, was seen across Western France, and almost immediately made the news in local and Parisian newspapers. Within a few weeks of the fall, a great diversity of analyses were performed under the authority of Gabriel Auguste Daubrée, geology professor at the Paris Museum, and published in the Comptes Rendus de l'Académie des Sciences. The skilled scientists reported the presence of iron sulfides, hydrated silicates, and carbonates in Orgueil. They also characterized ammonium salts which are now gone, and observed sulfates being remobilized at the surface of the stone. They identified the high water and carbon contents, and noted similarities with the Alais meteorite, which had fallen in 1806, 300 km away. While Daubrée and his colleagues noted the similarity of the Orgueil organic matter with some terrestrial humus, they were cautious not to make a direct link with living organisms. One century later, Nagy and Claus were less prudent and announced the discovery of "organized" elements in some samples of Orgueil. Their observations were quickly discredited by Edward Anders and others who also discovered that some pollen grains were intentionally placed into the rock back in the 1860s. Orgueil is now one of the most studied meteorites, indeed one of the most studied rocks of any kind. Not only does it contain a large diversity of carbon-rich compounds, which help address the question of organo-synthesis in the early solar system but its chemical composition is also close to that of the Sun's photosphere and serves as a cosmic reference. Secondary minerals, which make up 99% of the volume of Orgueil, were probably formed during hydrothermal alteration on the parent-body within the first few million years of the solar system; their study is essential to our

  20. Self-reported walking ability predicts functional mobility performance in frail older adults.

    PubMed

    Alexander, N B; Guire, K E; Thelen, D G; Ashton-Miller, J A; Schultz, A B; Grunawalt, J C; Giordani, B

    2000-11-01

    To determine how self-reported physical function relates to performance in each of three mobility domains: walking, stance maintenance, and rising from chairs. Cross-sectional analysis of older adults. University-based laboratory and community-based congregate housing facilities. Two hundred twenty-one older adults (mean age, 79.9 years; range, 60-102 years) without clinical evidence of dementia (mean Folstein Mini-Mental State score, 28; range, 24-30). We compared the responses of these older adults on a questionnaire battery used by the Established Populations for the Epidemiologic Study of the Elderly (EPESE) project, to performance on mobility tasks of graded difficulty. Responses to the EPESE battery included: (1) whether assistance was required to perform seven Katz activities of daily living (ADL) items, specifically with walking and transferring; (2) three Rosow-Breslau items, including the ability to walk up stairs and walk a half mile; and (3) five Nagi items, including difficulty stooping, reaching, and lifting objects. The performance measures included the ability to perform, and time taken to perform, tasks in three summary score domains: (1) walking ("Walking," seven tasks, including walking with an assistive device, turning, stair climbing, tandem walking); (2) stance maintenance ("Stance," six tasks, including unipedal, bipedal, tandem, and maximum lean); and (3) chair rise ("Chair Rise," six tasks, including rising from a variety of seat heights with and without the use of hands for assistance). A total score combines scores in each Walking, Stance, and Chair Rise domain. We also analyzed how cognitive/ behavioral factors such as depression and self-efficacy related to the residuals from the self-report and performance-based ANOVA models. Rosow-Breslau items have the strongest relationship with the three performance domains, Walking, Stance, and Chair Rise (eta-squared ranging from 0.21 to 0.44). These three performance domains are as strongly

  1. Marginal notes for a centenary

    NASA Astrophysics Data System (ADS)

    Balázs, Lajos G.

    2001-10-01

    The Astronomical Research Institute of the Hungarian Academy of Sciences celebrated its centenary on the 20th of May 1999. Due to several political and economical crises it was not so easy in Central Europe in the past century to produce scientific results up to the prevailing international standards. Regular professional astronomical activity started in Hungary with the foundation of the university in Nagyszombat near to the present Bratislava. In 1777 the university was transferred to Buda and an observatory was installed in the tower of the royal palace. At the beginning of the 19th century, in 1815, a new university observatory was opened on the top of the Gellert Hill. The observatory was completely destroyed during the siege of the Buda castle in 1849. The other professional astronomical observatory of Karoly Nagy at the town Bicske, completed just at the beginning of the war in 1848-49, was never allowed to make a contribution. A new start for Hungarian astronomy came from Miklós Konkoly Thege when he established his private observatory in Ógyalla. A significant step in the life of the observatory was when it became the property of the state on the 20th of May, 1899. Astronomical photometry was chosen as the main research field of the new national observatory. The first world war led to the collapse of the Austro-Hungarian empire and resulted in the splitting of Ógyalla from Hungary. The instrumentation was transferred to Hungary and the government decided in 1921 to build a new institute on the Schwabian Hills close to Buda. Research on variable stars became the main field of the new institute, in particular the study of period changes of short-period cepheids. After the second world war solar physics was restarted in the institute and as a result a new independent observatory was formed in 1958. A significant development was the introduction of photoelectric observations. In the fifties a decision was made on building a new mountain station on

  2. TW-class hollow-fiber compressor with tunable pulse duration (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Boehle, Frederik; Vernier, Aline; Kretschmar, Martin; Jullien, Aurélie; Kovacs, Mate; Romero, Rosa M.; Crespo, Helder M.; Simon, Peter; Nagy, Tamas; Lopez-Martens, Rodrigo

    2017-05-01

    mirrors using controllable relativistic-intensity light waveforms at 1kHz. [1] Krausz and Ivanov, Rev. Mod. Phys. 81, 163 (2009). [2] Borot et al., Nature Phys. 8, 417-421 (2012). [3] Nisoli et al., Appl. Phys. Lett. 68, 2793-2795 (1996). [4] Park et al., Opt. Lett. 34, 2342-2344 (2009). [5] Schweinberger et al., Opt. Lett. 37, 3573-5 (2012). [6] Chen et al., Opt. Lett. 34, 1588-1590 (2009). [7] Suda et al., Appl. Phys. Lett. 86, 111116 (2005). [8] Jacqmin et al., Opt. Lett. 40, 709-712 (2015) [9] Bohman et al., Opt. Lett. 35, 1887-9 (2010). [10] Nagy et al., Appl. Opt. 47, 3264-3268 (2008). [11] Boehle et al., Las. Phys. Lett. 11, 095401 (2014). [12] Miranda et al., Opt. Express 20, 18732-43 (2012)

  3. Survey, Representation and Analysis of a War i Complex System of Surface and Underground Fortifications in the Gresta Valley, Italy

    NASA Astrophysics Data System (ADS)

    Salvador, I.; Vitti, A.

    2011-09-01

    This work is part of a research on the use of terrestrial laser scanner, integrated with total station and GPS, for the documentation and comprehension of complex architectures in up-land sites. The research is performed in the framework of the project "Ambiente e Paesaggi dei siti di Altura Trentini" - APSAT (Environment and landscape of hill-top sites in Trentino), a multidisciplinary project focused on the evolution of hill-top anthropic system in the Trentino region, Italy. The study area is located in the Gresta Valley and this work concerns on the Nagià Grom site, fortified by the Austria-Hungarian Army during the World War I. The site has been interested by a significant restore operation of a large series of entrenches paths and fortifications in the last decade. The survey herein described has involved an area once interested by military barracks with Officers' Mess, water provision and by one of the biggest field kitchens discovered in the Trentino region. A second survey involved the tunnel connecting the ammunition depot to the artillery stations. The nature of such complex architectures, characterized by an irregular and composite 3D span leads, in general, to necessary simple surveys and representations and somehow to simplified studies too. The 3D point cloud, once filtered by the massive presence of dense vegetation, eventually constitutes a rich data set for further analyses on the spatial, geological, architectural and historical properties of the site. The analysis has been carried out on two different scales. At the architectural-scale, the comparison to historic photos has allowed to understand how the original structure of the barracks was made and to find building characters that now are lost. The on-site observation of the underground stratigraphic splices and their analysis in the 3D point cloud, e.g., spatial extension and slope, have permitted the understanding of the special excavation process guided by the practical advantage of

  4. Thymidine Kinase-Negative Herpes Simplex Virus 1 Can Efficiently Establish Persistent Infection in Neural Tissues of Nude Mice.

    PubMed

    Huang, Chih-Yu; Yao, Hui-Wen; Wang, Li-Chiu; Shen, Fang-Hsiu; Hsu, Sheng-Min; Chen, Shun-Hua

    2017-02-15

    Herpes simplex virus 1 (HSV-1) establishes latency in neural tissues of immunocompetent mice but persists in both peripheral and neural tissues of lymphocyte-deficient mice. Thymidine kinase (TK) is believed to be essential for HSV-1 to persist in neural tissues of immunocompromised mice, because infectious virus of a mutant with defects in both TK and UL24 is detected only in peripheral tissues, but not in neural tissues, of severe combined immunodeficiency mice (T. Valyi-Nagy, R. M. Gesser, B. Raengsakulrach, S. L. Deshmane, B. P. Randazzo, A. J. Dillner, and N. W. Fraser, Virology 199:484-490, 1994, https://doi.org/10.1006/viro.1994.1150). Here we find infiltration of CD4 and CD8 T cells in peripheral and neural tissues of mice infected with a TK-negative mutant. We therefore investigated the significance of viral TK and host T cells for HSV-1 to persist in neural tissues using three genetically engineered mutants with defects in only TK or in both TK and UL24 and two strains of nude mice. Surprisingly, all three mutants establish persistent infection in up to 100% of brain stems and 93% of trigeminal ganglia of adult nude mice at 28 days postinfection, as measured by the recovery of infectious virus. Thus, in mouse neural tissues, host T cells block persistent HSV-1 infection, and viral TK is dispensable for the virus to establish persistent infection. Furthermore, we found 30- to 200-fold more virus in neural tissues than in the eye and detected glycoprotein C, a true late viral antigen, in brainstem neurons of nude mice persistently infected with the TK-negative mutant, suggesting that adult mouse neurons can support the replication of TK-negative HSV-1. Acyclovir is used to treat herpes simplex virus 1 (HSV-1)-infected immunocompromised patients, but treatment is hindered by the emergence of drug-resistant viruses, mostly those with mutations in viral thymidine kinase (TK), which activates acyclovir. TK mutants are detected in brains of immunocompromised

  5. Thymidine Kinase-Negative Herpes Simplex Virus 1 Can Efficiently Establish Persistent Infection in Neural Tissues of Nude Mice

    PubMed Central

    Huang, Chih-Yu; Yao, Hui-Wen; Wang, Li-Chiu; Shen, Fang-Hsiu

    2016-01-01

    ABSTRACT Herpes simplex virus 1 (HSV-1) establishes latency in neural tissues of immunocompetent mice but persists in both peripheral and neural tissues of lymphocyte-deficient mice. Thymidine kinase (TK) is believed to be essential for HSV-1 to persist in neural tissues of immunocompromised mice, because infectious virus of a mutant with defects in both TK and UL24 is detected only in peripheral tissues, but not in neural tissues, of severe combined immunodeficiency mice (T. Valyi-Nagy, R. M. Gesser, B. Raengsakulrach, S. L. Deshmane, B. P. Randazzo, A. J. Dillner, and N. W. Fraser, Virology 199:484–490, 1994, https://doi.org/10.1006/viro.1994.1150). Here we find infiltration of CD4 and CD8 T cells in peripheral and neural tissues of mice infected with a TK-negative mutant. We therefore investigated the significance of viral TK and host T cells for HSV-1 to persist in neural tissues using three genetically engineered mutants with defects in only TK or in both TK and UL24 and two strains of nude mice. Surprisingly, all three mutants establish persistent infection in up to 100% of brain stems and 93% of trigeminal ganglia of adult nude mice at 28 days postinfection, as measured by the recovery of infectious virus. Thus, in mouse neural tissues, host T cells block persistent HSV-1 infection, and viral TK is dispensable for the virus to establish persistent infection. Furthermore, we found 30- to 200-fold more virus in neural tissues than in the eye and detected glycoprotein C, a true late viral antigen, in brainstem neurons of nude mice persistently infected with the TK-negative mutant, suggesting that adult mouse neurons can support the replication of TK-negative HSV-1. IMPORTANCE Acyclovir is used to treat herpes simplex virus 1 (HSV-1)-infected immunocompromised patients, but treatment is hindered by the emergence of drug-resistant viruses, mostly those with mutations in viral thymidine kinase (TK), which activates acyclovir. TK mutants are detected in brains of

  6. Disaggregating pain and its effect on physical functional limitations.

    PubMed

    Lichtenstein, M J; Dhanda, R; Cornell, J E; Escalante, A; Hazuda, H P

    1998-09-01

    Pain is a common impairment that limits the abilities of older persons. The purposes of this article are to: (i) describe the distribution of pain location using the McGill Pain Map (MPM) in a community-based cohort of aged subjects; (ii) investigate whether individual areas of pain could be sensibly grouped into regions of pain; (iii) determine whether intensity, frequency, and location constitute independent dimensions of pain; and (iv) determine whether these three pain dimensions make differential contributions to the presence of self-reported physical functional limitations. A total of 833 Mexican American and European American subjects, aged 65-79 years, were enrolled in the San Antonio Longitudinal Study of Aging and were interviewed in their homes between 1992 and 1996. A total of 373 (46%) of the subjects reported having pain in the past week. Physical functional limitations were ascertained using the nine items from the Nagi scale. Three composite scales were created: upper extremity, lower extremity, and total. Pain intensity and frequency were ascertained using the McGill Pain Questionnaire. Pain location was ascertained by using the MPM. Pain was reported in every area of the MPM. Using multiple groups confirmatory factor analysis, the 36 areas were grouped into 7 regions of pain: head, arms, hands and wrists, trunk, back, upper leg, and lower leg. Among persons with pain, pain frequency, intensity, and location were weakly associated with each other. Pain regions were primarily independent of each other, yet weak associations existed between 6 of the 21 pair-wise correlations between regions. Pain regions were differentially associated with individual physical functional limitations. Pain in the upper leg was associated with 8 of the 9 physical tasks. In multivariate analyses, age, gender, and ethnic group accounted for only 2-3% of the variance in physical tasks. In multivariate analyses, age, gender, and ethnic group accounted for only 2-3% of the

  7. A methodology for urban flood resilience assessment

    NASA Astrophysics Data System (ADS)

    Lhomme, Serge; Serre, Damien; Diab, Youssef; Laganier, Richard

    2010-05-01

    In Europe, river floods have been increasing in frequency and severity [Szöllösi-Nagy and Zevenbergen, 2005]. Moreover, climate change is expected to exacerbate the frequency and intensity of hydro meteorological disaster [IPCC, 2007]. Despite efforts made to maintain the flood defense assets, we often observe levee failures leading to finally increase flood risk in protected area. Furthermore, flood forecasting models, although benefiting continuous improvements, remain partly inaccurate due to uncertainties arising all along data calculation processes. In the same time, the year 2007 marks a turning point in history: half of the world population now lives in cities (UN-Habitat, 2007). Moreover, the total urban population is expected to double from two to four billion over the next 30 to 35 years (United Nations, 2006). This growing rate is equivalent to the creation of a new city of one million inhabitants every week, and this during the next four decades [Flood resilience Group]. So, this quick urban development coupled with technical failures and climate change have increased flood risk and corresponding challenges to urban flood risk management [Ashley et al., 2007], [Nie et al., 2009]. These circumstances oblige to manage flood risk by integrating new concepts like urban resilience. In recent years, resilience has become a central concept for risk management. This concept has emerged because a more resilient system is less vulnerable to risk and, therefore, more sustainable [Serre et al., 2010]. But urban flood resilience is a concept that has not yet been directly assessed. Therefore, when decision makers decide to use the resilience concept to manage urban flood, they have no tool to help them. That is why this paper proposes a methodology to assess urban flood resilience in order to make this concept operational. Networks affect the well-being of the people and the smooth functioning of services and, more generally, of economical activities. Yet

  8. [Multidimensional family therapy: which influences, which specificities?].

    PubMed

    Bonnaire, C; Bastard, N; Couteron, J-P; Har, A; Phan, O

    2014-10-01

    Among illegal psycho-active drugs, cannabis is the most consumed by French adolescents. Multidimensional family therapy (MDFT) is a family-based outpatient therapy which has been developed for adolescents with drug and behavioral problems. MDFT has shown its effectiveness in adolescents with substance abuse disorders (notably cannabis abuse) not only in the United States but also in Europe (International Cannabis Need of Treatment project). MDFT is a multidisciplinary approach and an evidence-based treatment, at the crossroads of developmental psychology, ecological theories and family therapy. Its psychotherapeutic techniques find its roots in a variety of approaches which include systemic family therapy and cognitive therapy. The aims of this paper are: to describe all the backgrounds of MDFT by highlighting its characteristics; to explain how structural and strategy therapies have influenced this approach; to explore the links between MDFT, brief strategic family therapy and multi systemic family therapy; and to underline the specificities of this family therapy method. The multidimensional family therapy was created on the bases of 1) the integration of multiple therapeutic techniques stemming from various family therapy theories; and 2) studies which have shown family therapy efficiency. Several trials have shown a better efficiency of MDFT compared to group treatment, cognitive-behavioral therapy and home-based treatment. Studies have also highlighted that MDFT led to superior treatment outcomes, especially among young people with severe drug use and psychiatric co-morbidities. In the field of systemic family therapies, MDFT was influenced by: 1) the structural family therapy (S. Minuchin), 2) the strategic family theory (J. Haley), and 3) the intergenerational family therapy (Bowen and Boszormenyi-Nagy). MDFT has specific aspects: MDFT therapists think in a multidimensional perspective (because an adolescent's drug abuse is a multidimensional disorder), they

  9. A new formula of the Gravitational Curvature for the prism

    NASA Astrophysics Data System (ADS)

    Grazia D'Urso, Maria

    2017-04-01

    formulas for computing a third-order gravitational tensor from volumetric mass density, disturbing gravitational potential, gravity anomaly and gravity disturbance. J Geod 89:141-157 [6] Šprlák M, Novák P (2016) Spherical gravitational curvature boundary-value problem. J Geod 90:727-739 [7] Hamáčková E, Šprlák M , Pitoňák M, Novák P (2016) Non-singular expressions for the spherical harmonic synthesis of gravitational curvatures in a local north-oriented reference frame. Comp & Geosc 88: 152-162 [8] D'Urso MG (2012) New expressions of the gravitational potential and its derivates for the prism. In Hotine-Marussi International Symposium on Mathematical Geodesy, 7rd. Sneeuw N, Novak P, Crespi M, Sansò F. Springer-Verlag, Berlin Heidelberg pp. 251-256 [9] D'Urso MG (2013) On the evaluation of the gravity effects of polyhedral bodies and a consistent treatment of related singularities. J Geod 87:239-252 [10] D'Urso MG (2014)Analytical computation of gravity effects for polyhedral bodies. J Geod 88:13-29 [11] Nagy D, Papp G, Benedek J (2000) The gravitational potential and its derivatives for the prism. J Geod 74:552-560 [12] Holstein H, Fitzgerald DJ, H. Stefanov H (2013) Gravimagnetic similarity for homogeneous rectangular prisms. 75th EAGE Conference & Exhibition, London

  10. Dissolution kinetics as a function of the Gibbs free energy of reaction: An experimental study based on albite feldspar

    NASA Astrophysics Data System (ADS)

    Hellmann, Roland; Tisserand, Delphine

    2006-01-01

    Here we report on an experimental investigation of the relation between the dissolution rate of albite feldspar and the Gibbs free energy of reaction, Δ Gr. The experiments were carried out in a continuously stirred flow-through reactor at 150 °C and pH (150 °C) 9.2. The dissolution rates R are based on steady-state Si and Al concentrations and sample mass loss. The overall relation between Δ Gr and R was determined over a free energy range of -150 < Δ Gr < -15.6 kJ mol -1. The data define a continuous and highly non-linear, sigmoidal relation between R and Δ Gr that is characterized by three distinct free energy regions. The region furthest from equilibrium, delimited by -150 < Δ Gr < -70 kJ mol -1, represents an extensive dissolution rate plateau with an average rate R¯=1.0×10-8molm-2s-1. In this free energy range the rates of dissolution are constant and independent of Δ Gr, as well as [Si] and [Al]. The free energy range delimited by -70 ⩽ Δ Gr ⩽ -25 kJ mol -1, referred to as the 'transition equilibrium' region, is characterized by a sharp decrease in dissolution rates with increasing Δ Gr, indicating a very strong inverse dependence of the rates on free energy. Dissolution nearest equilibrium, defined by Δ Gr > -25 kJ mol -1, represents the 'near equilibrium' region where the rates decrease as chemical equilibrium is approached, but with a much weaker dependence on Δ Gr. The lowest rate measured in this study, R = 6.2 × 10 -11 mol m -2 s -1 at Δ Gr = -16.3 kJ mol -1, is more than two orders of magnitude slower than the plateau rate. The data have been fitted to a rate equation (adapted from Burch et al. [Burch, T. E., Nagy, K. L., Lasaga, A. C., 1993. Free energy dependence of albite dissolution kinetics at 80 °C and pH 8.8. Chem. Geol.105, 137-162]) that represents the sum of two parallel reactions R=k1[1-exp(-ng)]+k2[1-exp(-g)], where k1 and k2 are rate constants that have been determined by regression, with values 1.02 × 10 -8 and 1

  11. An enigmatic source of hematitic carbonate beds containing vast amounts of iron oxidizers in a paleozoic metamorphic complex, South Hungary, Geresd-Hills, Ófalu.

    NASA Astrophysics Data System (ADS)

    Jáger, Viktor; Dabi, Gergely; Menyhárt, Adrienn

    2013-04-01

    neptunian dykes, their age must be younger than the paleozoic metamorphic event. They must be older than the Early Cretaceous dyke emplacement in the region, based on cross-cutting relation with limonite stained calcite veins, related to the volcanic activity (Dabi et al., 2011) In this region (Tisza-megaunit) continental rift-related alkali basaltic submarine volcanism was widespread during the Early Cretaceous epoch, when hypabyssal basaltic bodies (intrusive pillow basalts) intruded into unconsolidated sediments. Along these magmatic bodies low temperature hydrothermal circulation of seawater hydrolyzed basaltic glass and mafic minerals, and huge amount of Fe(II) was released and got into the lime mud that was saturated with anaerobic water, where iron oxidizing microorganisms thrived (Jáger et al., 2012).We propose a very similar paleoenvironmental model for Ófalu occurence, where low temperature, reductive iron-rich hydrothermal fluids penetrated soft sediments and contributed to the flourishing of iron-oxidizers. Due to subsequent tectonic events, these iron-rich sediments got into the fissures of the Ófalu metamorphic complex. This model is strenghtened by some borehole and outcrops where the Lower Cretaceous interpillow sediments and hyaloclastites rich in iron oxydes and intrusive pillow basalt can be found close to our investigated section. (Hetényi et al., 1976) This study was supported by the Developing Competitiveness of Universities in the South Transdanubian Region (SROP-4.2.1.B-10/2/KONV-2010-0002). Dabi, G., Siklósy, Z., Schubert, F., Bajnóczi, B., M. Tóth, T., 2011. The relevance of vein texture in understanding the past hydraulic behaviour of a crystalline rock mass: reconstruction of the palaeohydrology of the Mecsekalja Zone, South Hungary. Geofluids, 11, 309-327. Hetényi, R., Földi, M., Hámor, G., Nagy, I., Bilik, I., Jantsky, B. 1976. Magyarázó a Mecsek hegység földtani térképéhez 10 000-es sorozat. MÁFI Budapest (in hungarian). J

  12. Nature of the Venus thermosphere derived from satellite drag measurements (solicited paper)

    NASA Astrophysics Data System (ADS)

    Keating, G.; Theriot, M.; Bougher, S.

    2008-09-01

    -4197, 1992. [3] Keating, G.M.; Taylor, F.W.; Nicholson, J. V. II; and Hinson, E.W. : Short-Term Cyclic Variations and Diurnal Variations of the Venus Upper Atmosphere, Science, Vol. 205, No. 4401, 62-64, July 6, 1979. [4] Bougher, S. W.; Dickinson, R. E.; Ridley, E. C.; Roble, R. G.; Nagy, A. F.; and Cravens, T. E.: Venus mesosphere and thermosphere, II, Global circulation, temperature, and density variations, Icarus, Vol. 68, 284-312, 1986. [5] Keating, G. M. et al.: Evidence of Long-Term Global Decline in the Earth's Thermospheric Densities Apparently Related to Anthropogenic Effects, Geophysical Research Letters, Vol. 27, No. 10, 1522-1526, 2000. [6] Keating, G. M. et al.: Models of Venus Neutral Upper Atmosphere Structure and Composition: The Venus International Reference Atmosphere (Edited by A. L. Kliore, V. I. Moros, and G. M. Keating) Advances in Space Research, Vol. 5, No. 11, 117-171,1985. [7] Keating, G. M.; Hsu, N.C., and Lyu, J.: Improved Thermospheric Model for the Venus International Reference Atmosphere, Proceedings of the 31st Scientific Assembly of COSPAR, Birmingham, England, 139, 1996 (Invited) [8] Keating, G. M. and Hsu, N. C.: The Venus Atmospheric Response to Solar Cycle Variations, Geophysical Research Letters, Vol. 20, 2751-2754, 1993. [9] Keating, G.M. et al: Future drag measurements from Venus Express. Adv

  13. Periglacial landforms on Mars as evidence of undersurface ice

    NASA Astrophysics Data System (ADS)

    Sik, A.

    timescale when the partial melting of the ice content can not be ruled out and so a specially adapted organism can survive the frozen state in spore form and after revive in liquid water. If this conception is correct, recently Mars is in frozen state and we have to wait for the discovery of Martian life until a warmer period begin. 8. Proposal for future research We are planning to model these forms in the environment of our Hunveyor experimental space probe [9], but the best Earth-analogies (for its lithology, climate and orography as well) of these terrains are the McMurdo Dry Valleys of Antarctica [10]. So the new theories in connection with the topic of Martian periglacial environments should be tested there in the future. By doing so, and by a better understanding of correlation between morphology of terrestrial rock glaciers and climatic oscillation, we will able to refine our view of near-surface water-history and paleoclimate of Mars. References [1] www.msss.com; [2] lptwww.gsfc.nasa.gov/tharsis/mola.html; [3] Kereszturi, Á. and Sik, A. (2000) LPSC XXXI., #1216; [4] Squyres, S. W. et al. (1992) in Kieffer, H. H. et. al.: Mars, University of Arizona Press, Tucson, 523-554; [5] Carr, M. H. and Schaber, G. G. (1977) JGR, 82, 4039-4054; [6] Mangold, N. et. al. (2000) LPSC XXXI., #1131; [7] Vitek, J. D. (1987) in J. R. Giardino et. al.: Rock glaciers, Allen and Unwin, London, 239-264; [8] Humlum, O. (2000) Geomorphology, 35, 41-67; [9] Bérczi, Sz. et. al. (1999) LPSC XXX., #1332; [10] Nagy, B. and Szalai, Z.: Study of periglacial mass movements at King George Island (Southern Shetland Islands, Western Antarctica), Geographical Proceedings, in press.