Sample records for naim hamdia afgan
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The NAIMS cooperative pilot project: Design, implementation and future directions.
Oh, Jiwon; Bakshi, Rohit; Calabresi, Peter A; Crainiceanu, Ciprian; Henry, Roland G; Nair, Govind; Papinutto, Nico; Constable, R Todd; Reich, Daniel S; Pelletier, Daniel; Rooney, William; Schwartz, Daniel; Tagge, Ian; Shinohara, Russell T; Simon, Jack H; Sicotte, Nancy L
2017-10-01
The North American Imaging in Multiple Sclerosis (NAIMS) Cooperative represents a network of 27 academic centers focused on accelerating the pace of magnetic resonance imaging (MRI) research in multiple sclerosis (MS) through idea exchange and collaboration. Recently, NAIMS completed its first project evaluating the feasibility of implementation and reproducibility of quantitative MRI measures derived from scanning a single MS patient using a high-resolution 3T protocol at seven sites. The results showed the feasibility of utilizing advanced quantitative MRI measures in multicenter studies and demonstrated the importance of careful standardization of scanning protocols, central image processing, and strategies to account for inter-site variability.
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Kaye, Nicholas M; Christian, Eric L; Harris, Michael E
2002-04-09
The tRNA processing endonuclease ribonuclease P contains an essential and highly conserved RNA molecule (RNase P RNA) that is the catalytic subunit of the enzyme. To identify and characterize functional groups involved in RNase P RNA catalysis, we applied self-cleaving ribozyme-substrate conjugates, on the basis of the RNase P RNA from Escherichia coli, in nucleotide analogue interference mapping (NAIM) and site-specific modification experiments. At high monovalent ion concentrations (3 M) that facilitate protein-independent substrate binding, we find that the ribozyme is largely insensitive to analogue substitution and that concentrations of Mg2+ (1.25 mM) well below that necessary for optimal catalytic rate (>100 mM) are required to produce interference effects because of modification of nucleotide bases. An examination of the pH dependence of the reaction rate at 1.25 mM Mg2+ indicates that the increased sensitivity to analogue interference is not due to a change in the rate-limiting step. The nucleotide positions detected by NAIM under these conditions are located exclusively in the catalytic domain, consistent with the proposed global structure of the ribozyme, and predominantly occur within the highly conserved P1-P4 multihelix junction. Several sensitive positions in J3/4 and J2/4 are proximal to a previously identified site of divalent metal ion binding in the P1-P4 element. Kinetic analysis of ribozymes with site-specific N7-deazaadenosine and deazaguanosine modifications in J3/4 was, in general, consistent with the interference results and also permitted the analysis of sites not accessible by NAIM. These results show that, in this region only, modification of the N7 positions of A62, A65, and A66 resulted in measurable effects on reaction rate and modification at each position displayed distinct sensitivities to Mg2+ concentration. These results reveal a restricted subset of individual functional groups within the catalytic domain that are particularly
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A Deafening Silence: Hizballah After the American Invasion of Iraq
2007-01-01
see Saad-Ghorayeb, 168-186. 19 Verse 5:82, as quoted in Saad-Ghorayeb, 175. 20 Naim Kassem , “Hizbullah’s Future.” Available online at http...Lebanon-Israel Border.” Working Paper #368. Washington: Washington Institute for Near East Policy (04 Mar. 2002): online edition. Kassem , Naim...http://www.naimkassem.org (Website of Naim Kassem , Deputy Secretary- General of Hizballah) http://www.nasrollah.com (Website of Hassan
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Durability and Intelligent Nondestructive Evaluation of Adhesive Composite Joints
2000-09-22
PERFORMING ORGANIZATION NAME(S) AND ADDRESS( ES ) 8. PERFORMING ORGANIZATION University of Nebraska-Lincoln, Research Grants REPORTNUMBER & Contracts Office...Lincoln, NE 68588-0430 9. SPONSORING / MONrrORLNG AGENCY NAIME(S) AND ADDRESS( ES ) 10. SPONSORING / MONITORING AGENCY REPORT NUMBER * AFOSR 801 North...An MTS 10 MT load cell was used to measure loads. The tests were performed with a Satec spherical alignment coupling attached to the top grip. Acoustic
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NASA Astrophysics Data System (ADS)
Sirhan, Asal; Hamidi, Mohammad O.
2012-09-01
Multi-electrode geo-electrical and transient electromagnetic surveys were carried out to characterize the nature of the subsurface infiltration zones (5 to 20 m) related to a series of groundwater outlets, and to reveal the geometry of the different aquifers at Bani-Naim, in the south-eastern foothills of the Hebron area, West Bank, Palestine. The purpose of the surveys was to understand the link between water storage/transfer and the characteristics of the geological formations. The strata in this semi-arid region are composed of alternate layers of chalky limestone, hard limestone, marl and chalk. A total of 30 ERT and 15 TDEM were conducted at Bani Naim-Jahir and Bani Naim-Birein. A correlation between the results indicates various infiltration pathways: fractures, feature heterogeneities, and porous chalk. The local heterogeneity on the eastern side were the major pathways for the water infiltration, whereas the thick marl layer underneath acts as a natural impermeable barrier preventing water from infiltrating deeper. A combination of the different geophysical results identified conductive features that correspond to the infiltration zones supplying the dug wells with water. Furthermore, it was established that the fractured chalk and porous chalky limestone act as an aquifer. A three-dimensional visualization of the resistivity allowed a useful reconstruction of the shallow hydrogeological system. Consequently, these studies contribute to regional sustainable development projects in this semi-arid region.
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BioBlend.objects: metacomputing with Galaxy.
Leo, Simone; Pireddu, Luca; Cuccuru, Gianmauro; Lianas, Luca; Soranzo, Nicola; Afgan, Enis; Zanetti, Gianluigi
2014-10-01
BioBlend.objects is a new component of the BioBlend package, adding an object-oriented interface for the Galaxy REST-based application programming interface. It improves support for metacomputing on Galaxy entities by providing higher-level functionality and allowing users to more easily create programs to explore, query and create Galaxy datasets and workflows. BioBlend.objects is available online at https://github.com/afgane/bioblend. The new object-oriented API is implemented by the galaxy/objects subpackage. © The Author 2014. Published by Oxford University Press.
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Speciation of nanoscale objects by nanoparticle imprinted matrices
NASA Astrophysics Data System (ADS)
Hitrik, Maria; Pisman, Yamit; Wittstock, Gunther; Mandler, Daniel
2016-07-01
The toxicity of nanoparticles is not only a function of the constituting material but depends largely on their size, shape and stabilizing shell. Hence, the speciation of nanoscale objects, namely, their detection and separation based on the different species, similarly to heavy metals, is of outmost importance. Here we demonstrate the speciation of gold nanoparticles (AuNPs) and their electrochemical detection using the concept of ``nanoparticles imprinted matrices'' (NAIM). Negatively charged AuNPs are adsorbed as templates on a conducting surface previously modified with polyethylenimine (PEI). The selective matrix is formed by the adsorption of either oleic acid (OA) or poly(acrylic acid) (PAA) on the non-occupied areas. The AuNPs are removed by electrooxidation to form complementary voids. These voids are able to recognize the AuNPs selectively based on their size. Furthermore, the selectivity could be improved by adsorbing an additional layer of 1-hexadecylamine, which deepened the voids. Interestingly, silver nanoparticles (AgNPs) were also recognized if their size matched those of the template AuNPs. The steps in assembling the NAIMs and the reuptake of the nanoparticles were characterized carefully. The prospects for the analytical use of NAIMs, which are simple, of small dimension, cost-efficient and portable, are in the sensing and separation of nanoobjects.The toxicity of nanoparticles is not only a function of the constituting material but depends largely on their size, shape and stabilizing shell. Hence, the speciation of nanoscale objects, namely, their detection and separation based on the different species, similarly to heavy metals, is of outmost importance. Here we demonstrate the speciation of gold nanoparticles (AuNPs) and their electrochemical detection using the concept of ``nanoparticles imprinted matrices'' (NAIM). Negatively charged AuNPs are adsorbed as templates on a conducting surface previously modified with polyethylenimine (PEI). The
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Genetics Home Reference: congenital sucrase-isomaltase deficiency
... Leeb T, Naim HY. Novel mutations in the human sucrase-isomaltase gene (SI) that cause congenital carbohydrate malabsorption. Hum Mutat. 2006 Jan;27(1):119. Citation on PubMed Sibley E. Carbohydrate intolerance. Curr Opin Gastroenterol. 2004 Mar;20(2):162-7. Citation on PubMed More ...
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Translations on Eastern Europe Political, Sociological, and Military Affairs, Number 1417.
1977-07-15
Nenshati SO. Naime Beqiri 126. Vangjel Nano . 34. Feride Reci 81. Namik Kapaj 127. Vangjel Ngresi 35. Ferit Goskolli 82. Nasto Piperi...36. Filip Kota 85. Nekie Bedo 131. Vito Kapo 39. Floresha Diko 5<". Nik Nika 132. Xhevdet Kryeziu iii. Forti Frasheri 87. Nikoleta Thomallari
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BioBlend: automating pipeline analyses within Galaxy and CloudMan.
Sloggett, Clare; Goonasekera, Nuwan; Afgan, Enis
2013-07-01
We present BioBlend, a unified API in a high-level language (python) that wraps the functionality of Galaxy and CloudMan APIs. BioBlend makes it easy for bioinformaticians to automate end-to-end large data analysis, from scratch, in a way that is highly accessible to collaborators, by allowing them to both provide the required infrastructure and automate complex analyses over large datasets within the familiar Galaxy environment. http://bioblend.readthedocs.org/. Automated installation of BioBlend is available via PyPI (e.g. pip install bioblend). Alternatively, the source code is available from the GitHub repository (https://github.com/afgane/bioblend) under the MIT open source license. The library has been tested and is working on Linux, Macintosh and Windows-based systems.
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2008-12-01
Moises Naim emphasizes some realities; …and Erdogan (Turkish Prime Minister) are just two in a long list of world leaders who understand that while...Richard Lugar, The Brookings Institution 90th Leadership Forum Series March 13, 2006 (Transcript Prepared from a Tape Recording). 14 Figure 2...Ministers Erdogan and Karamanlis, with the personal support of U.S. Energy Secretary Bodman. The role of Turkey as a gas consumer, a transit partner
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The Roles of Primary Cilia in Cardiovascular System
2016-10-01
mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen . Biochem J 134:707–716. Boveris A, Oshino N, Chance B. 1972...The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen . Biochem J 134:707–716. Boveris A, Oshino N...Aim 1.2 (months 13-30): We will examine signaling mechanisms of cilia & their effects on blood pressure. Aim 2 (months 7-36). We will study
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Defining War in 21st Century America
2010-04-15
62 Moises Naim, “Mixed Metaphors: Why the wars on poverty, drugs, terror, drunk driving, teen pregnancy , and other ills can’t be won,” Foreign...constantly reinforcing the premise that the Iraqi people were not the enemy, but in fact , friends.6 New terms such as the “Long War” and “Overseas...politically palatable, simply change its name to mask its identity. If in fact the United States is incapable of coming to terms with what war
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Defining War in 21st Century America
2010-05-01
62 Moises Naim, “Mixed Metaphors: Why the wars on poverty, drugs, terror, drunk driving, teen pregnancy , and other ills can’t be won,” Foreign...constantly reinforcing the premise that the Iraqi people were not the enemy, but in fact , friends.6 New terms such as the “Long War” and “Overseas...politically palatable, simply change its name to mask its identity. If in fact the United States is incapable of coming to terms with what war
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NASA Astrophysics Data System (ADS)
Ahn, Sung Hee; Park, Kyung Man; Moon, Jeong Hee; Lee, Seong Hoon; Kim, Myung Soo
2016-11-01
The utility of sodium ion adducts produced by matrix-assisted laser desorption ionization for the quantification of analytes with multiple oxygen atoms was evaluated. Uses of homogeneous solid samples and temperature control allowed the acquisition of reproducible spectra. The method resulted in a direct proportionality between the ion abundance ratio I([A + Na]+)/I([M + Na]+) and the analyte concentration, which could be used as a calibration curve. This was demonstrated for carbohydrates, glycans, and polyether diols with dynamic range exceeding three orders of magnitude.
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NASA Astrophysics Data System (ADS)
Zhang, J.; Xu, M.; Pollard, A.; Mi, J.
2013-05-01
This study investigates by experiment the dependence of the inertial-range exponent m of the streamwise velocity spectrum on the external intermittency factor γ (≡ the fraction of time the flow is fully turbulent) and the mean shear S in a turbulent square jet. Velocity measurements were made using hot-wire anemometry in the jet at 15 < x/De < 40, where De denotes the exit equivalent diameter, and for an exit Reynolds number of Re = 50 000. The Taylor microscale Reynolds number Rλ varies from about 70 to 450 in the present study. The TERA (turbulent energy recognition algorithm) method proposed by Falco and Gendrich [in Near-Wall Turbulence: 1988 Zoran Zariç Memorial Conference, edited by S. J. Kline and N. H. Afgan (Hemisphere Publishing Corp., Washington, DC, 1990), pp. 911-931] is discussed and applied to estimate the intermittency factor from velocity signals. It is shown that m depends strongly on γ but negligibly on S. More specifically, m varies with γ following m=mt+(lnγ-0.0173)1/2, where mt denotes the spectral exponent found in fully turbulent regions.
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van Noort, Paul C M
2012-04-01
Abraham solvation equations find widespread use in environmental chemistry. Until now, the intercept in these equations was determined by fitting experimental data. To simplify the determination of the coefficients in Abraham solvation equations, this study derives theoretical expressions for the value of the intercept for various partition processes. To that end, a modification of the description of the Ben-Naim standard state into the van der Waals volume is proposed. Differences between predicted and fitted values of the Abraham solvation equation intercept for the enthalpy of solvation, the entropy of solvation, solvent-water partitioning, air-solvent partitioning, partitioning into micelles, partitioning into lipid membranes and lipids, and chromatographic retention indices are comparable to experimental uncertainties in these values. Copyright © 2011 Elsevier Ltd. All rights reserved.
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2011-10-01
protocol for training the TBI patients. References Bonneh, Y.S., Sagi, D., & Polat, U. (2007). Spatial and temporal crowding in amblyopia ...evidence from treatment of adult amblyopia . Restor Neurol Neurosci, 26 (4‐5), 413‐424. Polat, U. (2009). Making perceptual learning practical to improve...visual functions. Vision Res, 13 Polat, U., Ma‐Naim, T., Belkin, M., & Sagi, D. (2004). Improving vision in adult amblyopia by perceptual learning
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Molecular Dynamics implementation of BN2D or 'Mercedes Benz' water model
NASA Astrophysics Data System (ADS)
Scukins, Arturs; Bardik, Vitaliy; Pavlov, Evgen; Nerukh, Dmitry
2015-05-01
Two-dimensional 'Mercedes Benz' (MB) or BN2D water model (Naim, 1971) is implemented in Molecular Dynamics. It is known that the MB model can capture abnormal properties of real water (high heat capacity, minima of pressure and isothermal compressibility, negative thermal expansion coefficient) (Silverstein et al., 1998). In this work formulas for calculating the thermodynamic, structural and dynamic properties in microcanonical (NVE) and isothermal-isobaric (NPT) ensembles for the model from Molecular Dynamics simulation are derived and verified against known Monte Carlo results. The convergence of the thermodynamic properties and the system's numerical stability are investigated. The results qualitatively reproduce the peculiarities of real water making the model a visually convenient tool that also requires less computational resources, thus allowing simulations of large (hydrodynamic scale) molecular systems. We provide the open source code written in C/C++ for the BN2D water model implementation using Molecular Dynamics.
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Chegeni, Mohammad; Amiri, Mahdi; Nichols, Buford L; Naim, Hassan Y; Hamaker, Bruce R
2018-02-20
Dietary starch is finally converted to glucose for absorption by the small intestine mucosal α-glucosidases (sucrase-isomaltase [SI] and maltase-glucoamylase), and control of this process has health implications. Here, the molecular mechanisms were analyzed associated with starch-triggered maturation and transport of SI. Biosynthetic pulse-chase in Caco-2 cells revealed that the high MW SI species (265 kDa) induced by maltose (an α-amylase starch digestion product) had a higher rate of early trafficking and maturation compared with a glucose-induced SI (245 kDa). The maltose-induced SI was found to have higher affinity to lipid rafts, which are associated with enhanced targeting to the apical membrane and higher activity. Accordingly, in situ maltose-hydrolyzing action was enhanced in the maltose-treated cells. Thus, starch digestion products at the luminal surface of small intestinal enterocytes are sensed and accelerate the intracellular processing of SI to enhance starch digestion capacity in the intestinal lumen.-Chegeni, M., Amiri, M., Nichols, B. L., Naim, H. Y., Hamaker, B. R. Dietary starch breakdown product sensing mobilizes and apically activates α-glucosidases in small intestinal enterocytes.
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Petroleum resources of Libya, Algeria, and Egypt. Foreign energy supply assessment series
DOE Office of Scientific and Technical Information (OSTI.GOV)
Not Available
1984-03-01
Part 1 of the report is a synopsis of each country's location, its exploration and development history, crude oil field production history, and markets. Part 2 discusses the production and reserve characteristics of the oil fields and status of the known crude oil resources. Part 3 provides an assessment of the ultimately recoverable crude oil and the possible future rate of availability of the crude oil. Part 4 discusses the status of the known and undiscovered natural gas resources, production, and markets. Part 5 is an overview of the petroleum geology of the three countries and the physical characteristics ofmore » their crude oils. Appendix A presents an annual resume of historical production by field and by basin for Libya; Appendix B shows the historical production by field and by basin for Algeria; Appendix C shows the historical production by field and by basin for Egypt; Appendix D provides production tables for each country. Data presented in Appendixes A through D are derived mostly from the April 1982 publication, Libya, Algeria and Egypt-Crude Oil Potential From Known Deposits DOE/EIA-0338, by William D. Dietzman, Naim R. Rafidi, and Thomas A. Ross. Appendix E is a geologic timetable.« less
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Olfactory function and quality of life after olfaction rehabilitation in total laryngectomees.
Santos, Christiane Gouvêa Dos; Bergmann, Anke; Coça, Kaliani Lima; Garcia, Angela Albuquerque; Valente, Tânia Cristina de Oliveira
2016-01-01
To evaluate the effects of olfaction rehabilitation in the olfactory function and quality of life of total laryngectomized patients. Pre-post intervention clinical study conducted with total laryngectomees submitted to olfaction rehabilitation by means of the Nasal Airflow-Inducing Maneuver (NAIM) using the University of Pennsylvania Smell Identification Test (UPSIT), Olfactory Acuity Questionnaires, a Monitoring Questionnaire, and the University of Washington Quality of Life Questionnaire (UW-QOL). Participants were 45 total laryngectomees. Before olfaction rehabilitation, 48.9% of the participants had their olfactic abilities classified as anosmia, 46.8% as microsmia, and 4.4% were considered within the normal range. After olfaction rehabilitation, 4.4% of the participants were classified as anosmia and 31.1% were within the normal range. In the Smell Identification Test, the mean score after rehabilitation showed statistically significant improvement. Reponses to the Olfactory Acuity Questionnaires after rehabilitation showed improvement in the frequency of perception regarding smell, taste, and the ability to smell perfume, food, leaking gas, and smoke, after learning the maneuver. Although the scores in the Quality of Life Questionnaire already indicated good quality of life before the surgery, post-intervention values were statistically significant. Olfaction rehabilitation improves olfactory function and has a positive impact on the activities of daily living and quality of life of total laryngectomized patients.
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Hospital Universiti Sains Malaysia (HUSM): 25 Years Of Excellent Service
Kamari, Zaidun
2009-01-01
Our Hospital University Sains Malaysia (HUSM) was given the Cabinet approval to exist under the Ministry of Education on 23 November 1982. The Deputy Prime Minister during that period, Yang Berhormat Tun Musa Hitam announced this after the cabinet meeting was held together with the presence of the Yang Berhormat Ministers of Health; and Education, Director of the Public Works Department and the Implementation and Coordinating Unit, Prime Minister’s Department. The first patients moved in on 14 March 1983 and the inauguration of HUSM was done on 26 August 1984 by the Duli Yang Maha Mulia Tuanku Ismail Petra Ibni Al-Marhum Sultan Yahya Petra, the Sultan of Kelantan Darul Naim. HUSM celebrated it’s 25th anniversary at the Dewan Utama, USM Health Campus on the 15th December 2008 which was inaugurated by Yang Berhormat, Minister of Higher Education Dato’ Seri Mohamed Khaled Nordin. USM’s Vice Chancellor Professor Tan Sri Dato’ Dzulkifli Abdul Razak, Chairman of the USM Board of Directors Tan Sri Dato’ Haji Dr. Ani bin Arope, Health Campus Director Professor Dato’ Dr. Mafauzy Mohamed, former Campus Director, Dato’ Prof Mohd Roslani Abdul Majid, the current and previous Hospital Directors and Deputy Directors since 1983 were present. The achievements of HUSM since its establishment and its vision to fulfil the University’s Accelerated Programme for Excellence (APEX) are elaborated. PMID:22589644
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Dynamics of Nearest-Neighbour Competitions on Graphs
NASA Astrophysics Data System (ADS)
Rador, Tonguç
2017-10-01
Considering a collection of agents representing the vertices of a graph endowed with integer points, we study the asymptotic dynamics of the rate of the increase of their points according to a very simple rule: we randomly pick an an edge from the graph which unambiguously defines two agents we give a point the the agent with larger point with probability p and to the lagger with probability q such that p+q=1. The model we present is the most general version of the nearest-neighbour competition model introduced by Ben-Naim, Vazquez and Redner. We show that the model combines aspects of hyperbolic partial differential equations—as that of a conservation law—graph colouring and hyperplane arrangements. We discuss the properties of the model for general graphs but we confine in depth study to d-dimensional tori. We present a detailed study for the ring graph, which includes a chemical potential approximation to calculate all its statistics that gives rather accurate results. The two-dimensional torus, not studied in depth as the ring, is shown to possess critical behaviour in that the asymptotic speeds arrange themselves in two-coloured islands separated by borders of three other colours and the size of the islands obey power law distribution. We also show that in the large d limit the d-dimensional torus shows inverse sine law for the distribution of asymptotic speeds.
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Heide, C; Pfeiffer, T; Nolan, J M; Hartmann, R K
1999-01-01
We have identified by nucleotide analog interference mapping (NAIM) exocyclic NH2 groups of guanosines in RNase P RNA from Escherichia coli that are important for tRNA binding. The majority of affected guanosines represent phylogenetically conserved nucleotides. Several sites of interference could be assigned to direct contacts with the tRNA moiety, whereas others were interpreted as reflecting indirect effects on tRNA binding due to the disruption of tertiary contacts within the catalytic RNA. Our results support the involvement of the 2-NH2 groups of G292/G293 in pairing with C74 and C75 of tRNA CCA-termini, as well as formation of two consecutive base triples involving C75 and A76 of CCA-ends interacting with G292/A258 and G291/G259, respectively. Moreover, we present first biochemical evidence for two tertiary contacts (L18/P8 and L8/P4) within the catalytic RNA, whose formation has been postulated previously on the basis of phylogenetic comparative analyses. The tRNA binding interference data obtained in this and our previous studies are consistent with the formation of a consecutive nucleotide triple and quadruple between the tetraloop L18 and helix P8. Formation of the nucleotide triple (G316 and A94:U104 in wild-type E. coli RNase P RNA) is also supported by mutational analysis. For the mutant RNase P RNA carrying a G94:C104 double mutation, an additional G316-to-A mutation resulted in a restoration of binding affinity for mature and precursor tRNA. PMID:9917070
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Adawi, Mohammad; Bragazzi, Nicola Luigi; Watad, Abdulla; Sharif, Kassem; Amital, Howard; Mahroum, Naim
2017-12-01
Mayaro virus (MAYV), first discovered in Trinidad in 1954, is spread by the Haemagogus mosquito. Small outbreaks have been described in the past in the Amazon jungles of Brazil and other parts of South America. Recently, a case was reported in rural Haiti. Given the emerging importance of MAYV, we aimed to explore the feasibility of exploiting a Web-based tool for monitoring and tracking MAYV cases. Google Trends is an online tracking system. A Google-based approach is particularly useful to monitor especially infectious diseases epidemics. We searched Google Trends from its inception (from January 2004 through to May 2017) for MAYV-related Web searches worldwide. We noted a burst in search volumes in the period from July 2016 (relative search volume [RSV]=13%) to December 2016 (RSV=18%), with a peak in September 2016 (RSV=100%). Before this burst, the average search activity related to MAYV was very low (median 1%). MAYV-related queries were concentrated in the Caribbean. Scientific interest from the research community and media coverage affected digital seeking behavior. MAYV has always circulated in South America. Its recent appearance in the Caribbean has been a source of concern, which resulted in a burst of Internet queries. While Google Trends cannot be used to perform real-time epidemiological surveillance of MAYV, it can be exploited to capture the public's reaction to outbreaks. Public health workers should be aware of this, in that information and communication technologies could be used to communicate with users, reassure them about their concerns, and to empower them in making decisions affecting their health. ©Mohammad Adawi, Nicola Luigi Bragazzi, Abdulla Watad, Kassem Sharif, Howard Amital, Naim Mahroum. Originally published in JMIR Public Health and Surveillance (http://publichealth.jmir.org), 01.12.2017.
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Tao, Kelin; Zhao, Song; Gao, Pin; Wang, Lijin; Jia, Hanzhong
2018-06-06
Interactions between microorganisms and minerals have the potential contribution to remove polycyclic aromatic hydrocarbons (PAHs) in model systems. In this study, phenanthrene (PHE) was used as a probe molecule to explore the potential adsorption and biotransformation processes in the presence of microorganisms and various reference clays, such as montmorillonite (M), kaolinite (K), and pyrophyllite (P). Equilibrium adsorption experiments and scanning electron microscopy (SEM) technique were used to investigate the sorption of Pantoea agglomerans strains on clay minerals saturated with cations (Na + and Fe 3+ ). The adsorption isotherms of PHE and Pantoea agglomerans strains on cation-modified clay minerals fitted to Langmuir equation, and their adsorbed amounts both followed the sequence: montmorillonite > kaolinite > pyrophyllite. For six types of cation-modified minerals, the behavior of PHE adsorbed and Pantoea agglomerans adhered onto mentioned minerals was in the order of Na(I)-M > Fe(Ⅲ)-M, Na(I)-K > Fe(Ⅲ)-K and Fe(Ⅲ)-P > Na(I)-P, respectively. The biodegradation results showed that cation-modified clay minerals could enhance the biodegradation of PHE, ascribing to their large specific surface area, and cation exchange capability, as well as the difference in zeta potential between minerals and Pantoea agglomerans strains. Comparison of biodegradation rates displayed that PHE was degraded the highest in the presence of Na-M (93.285%). In addition, the obtained results suggested that the adhesion of bacteria onto cation-exchanged clay minerals was beneficial to the biodegradation of PHE. Anthracen-9-ylmethanol and 3,4-dimethyl-2-(3-methylbutanoyl)benzoic acid were detected as the main intermediate compounds, which can be further biodegraded into small molecules. The overall results obtained in this study are of valuable significance for the understanding of the behavior of PHE in soil and associated environment. Copyright © 2018 Elsevier Inc. All
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Glycine administration attenuates skeletal muscle wasting in a mouse model of cancer cachexia.
Ham, Daniel J; Murphy, Kate T; Chee, Annabel; Lynch, Gordon S; Koopman, René
2014-06-01
The non-essential amino acid, glycine, is often considered biologically neutral, but some studies indicate that it could be an effective anti-inflammatory agent. Since inflammation is central to the development of cancer cachexia, glycine supplementation represents a simple, safe and promising treatment. We tested the hypothesis that glycine supplementation reduces skeletal muscle inflammation and preserves muscle mass in tumor-bearing mice. To induce cachexia, CD2F1 mice received a subcutaneous injection of PBS (control, n = 12) or C26 tumor cells (n = 32) in accordance with the protocols developed by Murphy et al. [Murphy KT, Chee A, Trieu J, Naim T, Lynch GS. Importance of functional and metabolic impairments in the characterization of the C-26 murine model of cancer cachexia. Dis Models Mech 2012;5(4):533-545.]. Subcutaneous injections of glycine (n = 16) or PBS (n = 16) were administered daily for 21 days and at the conclusion of treatment, selected muscles, tumor and adipose tissue were collected and prepared for Real-Time RT-PCR or western blot analysis. Glycine attenuated the loss of fat and muscle mass, blunted increases in markers of inflammation (F4/80, P = 0.01 & IL-6 mRNA, P = 0.01) and atrophic signaling (MuRF, P = 0.047; atrogin-1, P = 0.04; LC3B, P = 0.06 and; BNIP3, P = 0.10) and tended to attenuate the loss of body mass (P = 0.07), muscle function (P = 0.06), and oxidative stress (GSSG/GSH, P = 0.06 and DHE, P = 0.07) seen in tumor-bearing mice. Preliminary studies that compared the effect of glycine administration with isonitrogenous doses of alanine or citrulline showed that the observed protective effect was specific to glycine. Glycine protects skeletal muscle from cancer-induced wasting and loss of function, reduces the oxidative and inflammatory burden, and reduces the expression of genes associated with muscle protein breakdown in cancer cachexia. Importantly, these effects were glycine specific. Copyright © 2013 Elsevier Ltd and European
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PREFACE: 5th International Conference on Mechatronics (ICOM'13)
NASA Astrophysics Data System (ADS)
Akramin Shafie, Amir; Raisuddin Khan, Md
2013-12-01
The Fifth International Conference on Mechatronics (ICOM2013), took place in Kuala Lumpur Malaysia from 2-4 July 2013. The biannual conference which started in 2001 is regularly organized by Faculty of Engineering, International Islamic University Malaysia (IIUM) with the aims to serve as a platform for exchange of ideas on advances of in mechatronics and their applications as well as to foster research and worldwide collaboration. The theme for the 2013 conference was 'Mechatronics: Sustainable Development through Innovative Solutions'. The ICOM 2013 Conference consisted of Keynote Speeches (5) and oral contributions (150). The topics of the conference were: Mechatronic systems and Applications Intelligent Systems Control and Instrumentation Signal and Image Processing Machine Vision Robotics and Automation Manufacturing Mechatronics Green Mechatronics Mechatronic Education Smart Materials and Structures Active Vibration Control Computer and Information Technology MEMS and NEMS Biomechatronics and Rehabilitation Engineering Autonomous Systems Energy and Sustainability Transportation System It is our great pleasure to present this volume of IOP Conference Series: Materials Science and Engineering (MSE) to the scientific community to promote further research in these areas. We believe that this volume will be both an excellent source of scientific material in the fast evolving fields that were covered by ICOM 2013. We thank the authors for their enthusiastic and high-grade contributions. We would also like to express our gratitude to the Organizing Committee, the Institutions and Sponsors and everyone who contributed to this conference through their supports and invaluable efforts. Editors Amir A Shafie aashafie@iium.edu.my Raisuddin Khan raisuddin@iium.edu.my Mahbubur Rashid mahbub@iium.edu.my Department of Mechatronics, International Islamic University Malaysia (IIUM), Kuala Lumpur Malaysia Organizing Committee Md Raisuddin Khan Md Mozasser Rahman Shahrul Naim