Influences of North Atlantic Oscillation (NAO) on warm season temperature and crop yields in the southwestern US

NASA Astrophysics Data System (ADS)

Myoung, B.; Kim, S.; Kim, J.; Kafatos, M.

2013-12-01

Despite advancements in agricultural technology, agricultural productivity remains vulnerable to extreme meteorological conditions. This study has found significant impacts of North Atlantic Oscillation (NAO) on extreme temperatures and in turn on crop yields in the Southwestern United States (SW US) region. Analyses of multi-year data of observed temperatures and simulated maize yields reveal that NAO affects positively the daily temperature maxima and minima in the green-up periods (March-June) and that the response of maize yields to NAO varies according to the climatological mean temperatures. In warmer regions, a combination of above-normal NAO in the planting periods and below-normal NAO in the growing periods is favorable for high maize yields by reducing extremely cold days during the planting periods and extremely hot days in the later periods, respectively. In colder regions, continuously above-normal NAO conditions favor higher yields via above normal thermal conditions. Results in this study suggest that NAO predictions can benefit agricultural planning in SW US.

The impact of AMO and NAO in Western Iberia during the Late Holocene

NASA Astrophysics Data System (ADS)

Hernandez, A.; Leira, M.; Trigo, R.; Vázquez-Loureiro, D.; Carballeira, R.; Sáez, A.

2016-12-01

High mountain lakes in the Iberian Peninsula are particularly sensitive to the influence of North Atlantic large-scale modes of climate variability due to their geographical position and the reduced anthropic disturbances. In this context, Serra da Estrela (Portugal), the westernmost range of the Sistema Central, constitutes a physical barrier to air masses coming from the Atlantic Ocean. However, long-term climate reconstructions have not yet been conducted. We present a climate reconstruction of this region based on facies analysis, X-ray fluorescence core scanning, elemental and isotope geochemistry on bulk organic matter and a preliminary study of diatom assemblages from the sedimentary record of Lake Peixão (1677 m a.s.l.; Serra da Estrela) for the last ca. 3500 years. A multivariate statistical analysis has been performed to recognize the main environmental factors controlling the sedimentary infill. Our results reveal that two main processes explain the 70% of the total variance. Thus, changes in primary productivity, reflected in organic matter accumulation, and variations in runoff, related to external particles input, explain 53% and 17% respectively. Additionally, evidence of changes in productivity and water level regime recorded as variations in diatom assemblages correlate well with our interpretations. A comparison between the lake productivity changes and previous Atlantic Multidecadal Oscillation (AMO) reconstructions shows a good correlation, suggesting this climate mode as the main driver over lacustrine primary productivity at multi-decadal scales. In turn, changes in terrigenous inputs, linked to precipitation, seem to be more influenced by the winter North Atlantic Oscillation (NAO) variability. Hence, our results highlight that although the climate regime in this area is clearly influenced by the NAO, the AMO also plays a key role at long-term time-scales.

Sharpest Ever VLT Images at NAOS-CONICA "First Light"

NASA Astrophysics Data System (ADS)

2001-12-01

Very Promising Start-Up of New Adaptive Optics Instrument at Paranal Summary A team of astronomers and engineers from French and German research institutes and ESO at the Paranal Observatory is celebrating the successful accomplishment of "First Light" for the NAOS-CONICA Adaptive Optics facility . With this event, another important milestone for the Very Large Telescope (VLT) project has been passed. Normally, the achievable image sharpness of a ground-based telescope is limited by the effect of atmospheric turbulence. However, with the Adaptive Optics (AO) technique, this drawback can be overcome and the telescope produces images that are at the theoretical limit, i.e., as sharp as if it were in space . Adaptive Optics works by means of a computer-controlled, flexible mirror that counteracts the image distortion induced by atmospheric turbulence in real time. The larger the main mirror of the telescope is, and the shorter the wavelength of the observed light, the sharper will be the images recorded. During a preceding four-week period of hard and concentrated work, the expert team assembled and installed this major astronomical instrument at the 8.2-m VLT YEPUN Unit Telescope (UT4). On November 25, 2001, following careful adjustments of this complex apparatus, a steady stream of photons from a southern star bounced off the computer-controlled deformable mirror inside NAOS and proceeded to form in CONICA the sharpest image produced so far by one of the VLT telescopes. With a core angular diameter of only 0.07 arcsec, this image is near the theoretical limit possible for a telescope of this size and at the infrared wavelength used for this demonstration (the K-band at 2.2 µm). Subsequent tests reached the spectacular performance of 0.04 arcsec in the J-band (wavelength 1.2 µm). "I am proud of this impressive achievement", says ESO Director General Catherine Cesarsky. "It shows the true potential of European science and technology and it provides a fine

Internal Climatic Influences From Secular To Multi-decadal Scales: Comparison Of NAO Reconstructions.

NASA Astrophysics Data System (ADS)

Nicolle, M.; Debret, M.; Massei, N.; de Vernal, A.

2017-12-01

In the Northern Hemisphere, the North Atlantic Oscillation (NAO) is the major dominant mode of variability in winter atmospheric circulation, with large impacts on temperature, precipitation and storm tracks in the North Atlantic sector. To understand the role of this internal climatic oscillations on the past climate variability, several proxy-based reconstructions of the NAO were published during the last decades. Two of them are available during the past 1,200 years: a first NAO reconstruction published by Trouet et al. (2009) and a second proposed by Ortega et al. (2015). The major discrepancy between the two reconstructions concerns the transition period between the Medieval Climate Anomaly (MCA) and the Little Ice Age. The first NAO reconstruction shows persistent positive phases during the MCA (AD 1000-1300) but this dominant trend is not highlighted in the reconstruction proposed by Ortega et al. (2015), asking the question of the influence of predictors used to reconstruct the NAO signal during the last millennia. In these study, we compare the two NAO reconstructions in order to determine the effect of bi-proxy or multi-proxy approach on the signal reconstructed. Using statistical and wavelet analysis methods, we conclude that the number of predictors used do not have impact on the signal reconstruct. The two reconstructions signals are characterized by similar variabilities expressed from multi-decadal to multi-secular scales. The major trend difference seems to be link to the type of the predictor and particularly the use of Greenland ice cores in the reconstruction proposed in 2015.

The effect of the East Atlantic pattern on the precipitation δ18O-NAO relationship in Europe

NASA Astrophysics Data System (ADS)

Comas-Bru, L.; McDermott, F.; Werner, M.

2016-10-01

The North Atlantic Oscillation (NAO) is known to influence precipitation δ18O (δ18Op) through its control on air temperature and on the trajectory of the westerly winds that carry moisture onto Europe during boreal winters. Hence, paleoclimate studies seeking to reconstruct the NAO can exploit the δ18O signal that is commonly preserved in natural archives such as stalagmites, ice cores, tree rings and lake sediments. However, such reconstructions should consider the uncertainties that arise from non-stationarities in the δ18Op-NAO relationship. Here, new insights into the causes of these temporal non-stationarities are presented for the European region using both observations (GNIP database) and the output of an isotope-enabled general circulation model (ECHAM5-wiso). The results show that, although the East Atlantic (EA) pattern is generally uncorrelated to δ18Op during the instrumental period, its polarity affects the δ18Op-NAO relationship. Non-stationarities in this relationship result from spatial shifts of the δ18Op-NAO correlated areas as a consequence of different NAO/EA combinations. These shifts are consistent with those reported previously for NAO-winter climate variables and the resulting non-stationarities mean that δ18O-based NAO reconstructions could be compromised if the balance of positive and negative NAO/EA states differs substantially in a calibration period compared with the period of interest in the past. The same approach has been followed to assess the relationships between δ18Op and both winter total precipitation and winter mean surface air temperature, with similar results. Crucially, this study also identifies regions within Europe where temporal changes in the NAO, air temperature and precipitation can be more robustly reconstructed using δ18O time series from natural archives, irrespective of concomitant changes in the EA.

Novel synthesis approach for stable sodium superoxide (NaO2) nanoparticles for LPG sensing application

NASA Astrophysics Data System (ADS)

Nemade, Kailash; Waghuley, Sandeep

2017-05-01

The synthesis of stable superoxide is still great challenge for the researchers working in the field of materials science. Through this letter, we report the novel and simple synthesis approach for the preparation of stable sodium superoxide (NaO2) nanoparticles. NaO2 nanoparticles were prepared by a spray pyrolysis technique, under oxygen rich environment for gas sensing application. The texture characterizations show that as-obtained NaO2 nanoparticles have high structural purity. Most importantly, NaO2 nanoparticles exhibits higher sensing response, shorter response time and recovery time, low operating temperature and good stability during sensing of liquefied petroleum gas (LPG). The main accomplishment of present work is that as-fabricated sensor has low operating temperature (423 K), which is below auto-ignition temperature of LPG. The gas sensing mechanism of NaO2 nanoparticles was discussed without the conventional oxygen bridging mechanism. Through this short communication, LPG sensing application of stable sodium superoxide nanoparticle is explored.

European land CO2 sink influenced by NAO and East-Atlantic Pattern coupling.

PubMed

Bastos, Ana; Janssens, Ivan A; Gouveia, Célia M; Trigo, Ricardo M; Ciais, Philippe; Chevallier, Frédéric; Peñuelas, Josep; Rödenbeck, Christian; Piao, Shilong; Friedlingstein, Pierre; Running, Steven W

2016-01-18

Large-scale climate patterns control variability in the global carbon sink. In Europe, the North-Atlantic Oscillation (NAO) influences vegetation activity, however the East-Atlantic (EA) pattern is known to modulate NAO strength and location. Using observation-driven and modelled data sets, we show that multi-annual variability patterns of European Net Biome Productivity (NBP) are linked to anomalies in heat and water transport controlled by the NAO-EA interplay. Enhanced NBP occurs when NAO and EA are both in negative phase, associated with cool summers with wet soils which enhance photosynthesis. During anti-phase periods, NBP is reduced through distinct impacts of climate anomalies in photosynthesis and respiration. The predominance of anti-phase years in the early 2000s may explain the European-wide reduction of carbon uptake during this period, reported in previous studies. Results show that improving the capability of simulating atmospheric circulation patterns may better constrain regional carbon sink variability in coupled carbon-climate models.

Norwegian fjord sediments reveal NAO related winter temperature and precipitation changes of the past 2800 years

NASA Astrophysics Data System (ADS)

Faust, Johan C.; Fabian, Karl; Milzer, Gesa; Giraudeau, Jacques; Knies, Jochen

2016-02-01

The North Atlantic Oscillation (NAO) is the leading mode of atmospheric circulation variability in the North Atlantic region. Associated shifts of storm tracks, precipitation and temperature patterns affect energy supply and demand, fisheries and agricultural, as well as marine and terrestrial ecological dynamics. Long-term NAO records are crucial to better understand its response to climate forcing factors, and assess predictability and shifts associated with ongoing climate change. A recent study of instrumental time series revealed NAO as main factor for a strong relation between winter temperature, precipitation and river discharge in central Norway over the past 50 years. Here we compare geochemical measurements with instrumental data and show that primary productivity recorded in central Norwegian fjord sediments is sensitive to NAO variability. This observation is used to calibrate paleoproductivity changes to a 500-year reconstruction of winter NAO (Luterbacher et al., 2001). Conditioned on a stationary relation between our climate proxy and the NAO we establish a first high resolution NAO proxy record (NAOTFJ) from marine sediments covering the past 2800 years. The NAOTFJ shows distinct co-variability with climate changes over Greenland, solar activity and Northern Hemisphere glacier dynamics as well as climatically associated paleo-demographic trends. The here presented climate record shows that fjord sediments provide crucial information for an improved understanding of the linkages between atmospheric circulation, solar and oceanic forcing factors.

Beyond the NAO: Dynamics and Precipitation Implications of the Azores High Since AD 800

NASA Astrophysics Data System (ADS)

Thatcher, D.; Wanamaker, A. D.; Denniston, R. F.; Asmerom, Y.; Ummenhofer, C.; Polyak, V. J.; Haws, J.; Gillikin, D. P.

2016-12-01

Atmospheric circulation in the North Atlantic region during the last millennium, particularly the state of the North Atlantic Oscillation (NAO), a system closely tied to regional precipitation dynamics, remains the subject of considerable debate in both proxy- and model-based studies. It has been suggested that the winter NAO was in a persistently positive state during the Medieval Climate Anomaly (MCA; AD 850-1250), resulting in increased precipitation across much of northern Europe and decreased rainfall across Iberia. However, besides changes in atmospheric circulation and precipitation dynamics that could be associated with an altered mean state of the NAO, relatively little attention has been given to atmospheric dynamics, namely the intensity and location, of the subtropical high system (Azores High, the southern node of the NAO) in driving hydroclimate in Iberia. Presented here is a continuous, precisely dated, and sub-decadally-resolved stalagmite isotopic and elemental time series from Buraca Gloriosa (BG) cave, western Portugal, situated within the center of the Azores High at the southern node of the NAO, which preserves evidence of regional hydroclimate from approximately AD 800 to the present. Stalagmite oxygen and carbon isotopic values and magnesium/calcium ratios primarily reflect effective moisture and reveal generally dry conditions during the MCA with a rapid shift to wetter conditions during the Little Ice Age (LIA; AD 1250-1850) at this location. Our proxy data reveal that substantial short-term hydroclimate variability characterized the last 1200 years. They support the hypothesis that while an intensified, semi-persistent subtropical high (and likely positive NAO state) characterized much of the MCA, the NAO remained variable over this time period. Climate model results also suggest that the Azores High pressure system both migrated southward and weakened from the MCA into the LIA.

Dependence of winter precipitation over Portugal on NAO and baroclinic wave activity

NASA Astrophysics Data System (ADS)

Ulbrich, U.; Christoph, M.; Pinto, J. G.; Corte-Real, J.

1999-03-01

The relationship between winter (DJF) rainfall over Portugal and the variable large scale circulation is addressed. It is shown that the poles of the sea level pressure (SLP) field variability associated with rainfall variability are shifted about 15° northward with respect to those used in standard definitions of the North Atlantic Oscillation (NAO). It is suggested that the influence of NAO on rainfall dominantly arises from the associated advection of humidity from the Atlantic Ocean. Rainfall is also related to different aspects of baroclinic wave activity, the variability of the latter quantity in turn being largely dependent on the NAO.A negative NAO index (leading to increased westerly surface geostrophic winds into Portugal) is associated with an increased number of deep (ps<980 hPa) surface lows over the central North Atlantic and of intermediate (980NAO is the mid-tropospheric storm track (defined by the 500 hPa bandpass-filtered geopotential height variance). A possible local influence of the storm track due to vertical motions ahead of the upper air troughs cannot be unambiguously separated from the effect of advection. A separate influence of local surface cyclones over the Iberian peninsula which may, for instance, arise from the large scale ascent of air, is revealed by the statistics: for a given advection, rainfall amounts for months with local cyclone cores over the considered region tend to exceed those without.

Strain identification and quorum sensing inhibition characterization of marine-derived Rhizobium sp. NAO1

NASA Astrophysics Data System (ADS)

Chang, Hong; Zhou, Jin; Zhu, Xiaoshan; Yu, Shenchen; Chen, Lu; Jin, Hui; Cai, Zhonghua

2017-03-01

A novel strategy for combating pathogens is through the ongoing development and use of anti-quorum sensing (QS) treatments such as therapeutic bacteria or their anti-QS substances. Relatively little is known about the bacteria that inhabit the open ocean and of their potential anti-pathogenic attributes; thus, in an initiative to identify these types of therapeutic bacteria, planktonic microbes from the North Atlantic Ocean were collected, isolated, cultured and screened for anti-QS activity. Screening analysis identified one such strain, Rhizobium sp. NAO1. Extracts of Rhizobium sp. NAO1 were identified via ultra-performance liquid chromatography (UPLC) analysis. They were shown to contain N-acyl homoserine lactone (AHL)-based QS analogues (in particular, the N-butyryl homoserine lactone (C4-AHL) analogue) and could disrupt biofilm formation by Pseudomonas aeruginosa PAO1. QS inhibition was confirmed using confocal scanning laser microscopy and growth curves, and it was shown to occur in a dose-dependent manner without affecting bacterial growth. Secondary metabolites of Rhizobium sp. NAO1 inhibited PAO1 pathogenicity by downregulating AHL-mediated virulence factors such as elastase activity and siderophore production. Furthermore, as a result of biofilm structure damage, the secondary metabolite products of Rhizobium sp. NAO1 significantly increased the sensitivity of PAO1 to aminoglycoside antibiotics. Our results demonstrated that Rhizobium sp. strain NAO1 has the ability to disrupt P. aeruginosa PAO1 biofilm architecture, in addition to attenuating P. aeruginosa PAO1 virulence factor production and pathogenicity. Therefore, the newly identified ocean-derived Rhizobium sp. NAO1 has the potential to serve as a QS inhibitor and may be a new microbial resource for drug development.

Lagged correlations between the NAO and the 11-year solar cycle: forced response or internal variability?

NASA Astrophysics Data System (ADS)

Oehrlein, J.; Chiodo, G.; Polvani, L. M.; Smith, A. K.

2017-12-01

Recently, the North Atlantic Oscillation has been suggested to respond to the 11-year solar cycle with a lag of a few years. The solar/NAO relationship provides a potential pathway for solar activity to modulate surface climate. However, a short observational record paired with the strong internal variability of the NAO raises questions about the robustness of the claimed solar/NAO relationship. For the first time, we investigate the robustness of the solar/NAO signal in four different reanalysis data sets and long integrations from an ocean-coupled chemistry-climate model forced with the 11-year solar cycle. The signal appears to be robust in the different reanalysis datasets. We also show, for the first time, that many features of the observed signal, such as amplitude, spatial pattern, and lag of 2/3 years, can be accurately reproduced in our model simulations. However, in both the reanalysis and model simulations, we find that this signal is non-stationary. A lagged NAO/solar signal can also be reproduced in two sets of model integrations without the 11-year solar cycle. This suggests that the correlation found in observational data could be the result of internal decadal variability in the NAO and not a response to the solar cycle. This has wide implications towards the interpretation of solar signals in observational data.

Evidence of long-term NAO influence on East-Central Europe winter precipitation from a guano-derived δ15N record.

PubMed

Cleary, Daniel M; Wynn, Jonathan G; Ionita, Monica; Forray, Ferenc L; Onac, Bogdan P

2017-10-26

Currently there is a scarcity of paleo-records related to the North Atlantic Oscillation (NAO), particularly in East-Central Europe (ECE). Here we report δ 15 N analysis of guano from a cave in NW Romania with the intent of reconstructing past variation in ECE hydroclimate and examine NAO impacts on winter precipitation. We argue that the δ 15 N values of guano indicate that the nitrogen cycle is hydrologically controlled and the δ 15 N values likely reflect winter precipitation related to nitrogen mineralization prior to the growing season. Drier conditions indicated by δ 15 N values at AD 1848-1852 and AD 1880-1930 correspond to the positive phase of the NAO. The increased frequency of negative phases of the NAO between AD 1940-1975 is contemporaneous with higher δ 15 N values (wetter conditions). A 4‰ decrease in δ 15 N values at the end of the 1970's corresponds to a strong reduction in precipitation associated with a shift from negative to positive phase of the NAO. Using the relationship between NAO index and δ 15 N values in guano for the instrumental period, we reconstructed NAO-like phases back to AD 1650. Our results advocate that δ 15 N values of guano offer a proxy of the NAO conditions in the more distant past, helping assess its predictability.

Characterization of Bacillus subtilis strains in Thua nao, a traditional fermented soybean food in northern Thailand.

PubMed

Inatsu, Y; Nakamura, N; Yuriko, Y; Fushimi, T; Watanasiritum, L; Kawamoto, S

2006-09-01

To clarify the diversity of Bacillus subtilis strains in Thua nao that produce high concentrations of products useful in food manufacturing and in health-promoting compounds. Production of amylase, protease, subtilisin NAT (nattokinase), and gamma-polyglutamic acid (PGA) by the Bacillus subtilis strains in Thua nao was measured. Productivity of protease NAT by these strains tended to be higher than by Japanese commercial natto-producing strains. Molecular diversity of isolated strains was analysed via randomly amplified polymorphic DNA-PCR fingerprinting. The strains were divided into 19 types, including a type with the same pattern as a Japanese natto-producing strain. B. subtilis strains that could be a resource for effective production of protease, amylase, subtilisin NAT, or PGA were evident in Thua nao produced in various regions in northern Thailand. This study clearly demonstrated the value of Thua nao as a potential resource of food-processing enzymes and health-promoting compounds.

The lagged connection of the positive NAO with the MJO phase 3 in a simplified atmospheric model

NASA Astrophysics Data System (ADS)

Shao, Xiaolu; Song, Jie; Li, Shuanglin

2018-03-01

Based on a simplified nonlinear model and reanalysis data, the lagged connection of the North Atlantic Oscillation (NAO) with the Madden-Julian Oscillation (MJO) in boreal winters is investigated. The positive NAO is observed to occur more frequently about 8-20 days after the onset of the MJO phase 3. A series of heating forcing experiments and initial-value experiments are conducted by utilizing the Geophysical Fluid Dynamics Laboratory (GFDL) dynamical core atmospheric model. The extratropical responses to the tropical heating associated with the MJO phase 3 are characterized by a wave train over the Pacific-North American region with an anticyclone anomaly over the northeastern Pacific and then followed by a positive-NAO-like pattern over the North Atlantic sector. These circulation anomalies generally match the observed lagged-connection well. At the earlier stage, the Rossby wave train excited by the MJO convection propagates into the North Atlantic, leading to a planetary wave anomaly with a low-over-high dipole prior to the positive NAO. At the later stage, the anomalous synoptic eddy vorticity forcing (EVF) streamfunction tendency has a negative-over-positive dipole, which plays a key role in the development of the positive NAO. Further analysis of the initial-value experiments indicates that, for the subsequent formation of the positive NAO, the anomalous circulation over the Indian Ocean aroused by the MJO phase 3 is more crucial than that over the northeastern Pacific.

European land CO2 sink influenced by NAO and East-Atlantic Pattern coupling

PubMed Central

Bastos, Ana; Janssens, Ivan A.; Gouveia, Célia M.; Trigo, Ricardo M.; Ciais, Philippe; Chevallier, Frédéric; Peñuelas, Josep; Rödenbeck, Christian; Piao, Shilong; Friedlingstein, Pierre; Running, Steven W.

2016-01-01

Large-scale climate patterns control variability in the global carbon sink. In Europe, the North-Atlantic Oscillation (NAO) influences vegetation activity, however the East-Atlantic (EA) pattern is known to modulate NAO strength and location. Using observation-driven and modelled data sets, we show that multi-annual variability patterns of European Net Biome Productivity (NBP) are linked to anomalies in heat and water transport controlled by the NAO–EA interplay. Enhanced NBP occurs when NAO and EA are both in negative phase, associated with cool summers with wet soils which enhance photosynthesis. During anti-phase periods, NBP is reduced through distinct impacts of climate anomalies in photosynthesis and respiration. The predominance of anti-phase years in the early 2000s may explain the European-wide reduction of carbon uptake during this period, reported in previous studies. Results show that improving the capability of simulating atmospheric circulation patterns may better constrain regional carbon sink variability in coupled carbon-climate models. PMID:26777730

Tropical Pacific forcing on decadal-to-centennial NAO-dominated precipitation variability in northern Mediterranean over the past 6500 years

NASA Astrophysics Data System (ADS)

Hu, H. M.; Shen, C. C.; Michel, V.; Jiang, X.; Mii, H. S.; Wang, Y.; Valensi, P.

2017-12-01

We present a multi-annual-resolved absolute-dated stalagmite-inferred precipitation record, with age precision as good as ±2 years, from northern Italy, to reflect North Atlantic Oscillation (NAO) dynamics since 6.5 ka (thousand years ago, before 1950 C.E.). Our record features millennial precipitation fluctuations punctuated by several centennial-scale drought periods centered at 5.6, 6.2, 4.2, 3.0 and 2.3 ka. The phase relationship with previous NAO-sensitive records suggests a multi-millennial southward migration of the northern Westerlies and enhanced NAO variability from the middle- to late-Holocene. We also found the multi-decadal to centennial rainfall amount could dramatically vary within few decades, possibly affecting ancient Mediterranean civilizations. Concurrence between northern Mediterranean precipitation and western tropical Pacific sea surface temperature records suggests the remote forcing on this NAO-dominated rainfall. We argue that the irregular NAO change nowadays could be related to high frequency of El Niño-Southern Oscillation events and might cause an inevitable abrupt hydroclimate change and irreparable impacts on the regional human society in the near future.

Understanding the NAO from Iberian and UK paleoclimate records. The NAOSIPUK project

NASA Astrophysics Data System (ADS)

Garcia-Alix, Antonio; Toney, Jaime L.; Jiménez-Moreno, Gonzalo; Slaymark, Charlotte; José Ramos-Román, Maria; Camuera, Jon; Jiménez-Espejo, Francisco J.; Anderson, R. Scott

2017-04-01

The main goal of the NAOSIPUK project was to understand the North Atlantic Oscillation (NAO) during the Holocene, because the NAO is one major climate mode influencing climate patterns across Europe, and therefore, economy and society (Hurrell, 1995). We analysed several sedimentary records in two regions with opposing NAO responses. Our sedimentary surface survey from numerous lakes and bogs, led to further investigation of four records in the southern Iberian Peninsula and three in the central/northern UK. Past environments of the different sites were analysed using pollen and charcoal analysis, organic and inorganic geochemistry analyses, and sedimentary and geophysical surveys were performed. This work compares general environmental trends in both regions as deduced from the organic matter from bulk sediment to get an idea of the organic matter source, as well as specific organic compounds extracted from the sediment, such as leaf waxes (n-alkanes), algae-related compounds (diols and alkenones), and bacteria-related compounds (hopanes), to specify the sources of the organic matter, environmental temperature ranges, as well as hydrological changes. Our preliminary results show that the palaeoenvironmental indices developed from n-alkanes agree with the variations deduced from the carbon and nitrogen atomic ratios, as well as the carbon isotopic composition from bulk sediments in southern Iberia records. Interestingly, these indices show that some locations display opposite trends from one another, and are used to distinguish regional versus local effects of climate change, human impacts, and aeolian dust inputs. During the late Holocene solar forcing and NAO fluctuations are the main drivers of the environmental evolution in most of the Iberian and UK sites. However, we do detect the influence of the NAO in the temperatures oscillations of the studied sites in southern Iberia. This influence is much more important in the north/central UK sites. The regional

Trends in characteristics of daily rainfall in Northern Iberia: Is the NAO signal behind the observed variability?

NASA Astrophysics Data System (ADS)

Saez de Cámara, E.; Gangoiti, G.; Alonso, L.; Iza, J.

2012-04-01

A trend analysis of intensity and frequency of daily precipitation over Northern Iberia (NIB), with a primary focus on extreme events, is presented. It is based on 14 NOAA-NCDC daily records covering the last 35 years (1973-2007) plus two centenarian databases sited in eastern NIB: San Sebastián (1929-2007) (daily resolution) and Bilbao (1857-2007) (monthly resolution). It is the first time that this interfacial region between the Atlantic and the Mediterranean has been studied with such a density of monitoring stations. Spatial and temporal characteristics and changes in rainfall's distribution have been analyzed using the suite of indices developed and recommended by the Expert Team on Climate Change Detection, Monitoring and Indices (ETCCDMI). They include annual and seasonal accumulated precipitation, number of dry and rainy days, and mean precipitation per rainy day, among others. The observed trends have been tested for statistical significance using the Mann-Kendall's non-parametric test. Additionally, links between the North Atlantic Oscillation (NAO) and the precipitation in the aforementioned region have been explored. The analysis shows a significant tendency towards less intensive rainy days for the whole region together with a decreasing trend in the number of wet days for the Central NIB. The consequence is a decline of total rainfall, statistically significant in Central and Eastern NIB. The evolution to drier conditions may be seen in both annual and seasonal indices. Conversely, strong regional differences have been found in the response to the NAO signal: whereas the rainfall decrease in the Western NIB might be associated to the dominance of a positive mode of the NAO during the last decades, the lack of correlation between the NAO signal and the observed precipitation in the stations with significant decreases rises an important argument against a direct association. Using the global gridded 6-hourly NCEP-DOE Reanalysis 2 data (1979-2010) we

AO/NAO Response to Climate Change. 1; Respective Influences of Stratospheric and Tropospheric Climate Changes

NASA Technical Reports Server (NTRS)

Rind, D.; Perlwitz, J.; Lonergan, P.

2005-01-01

We utilize the GISS Global Climate Middle Atmosphere Model and 8 different climate change experiments, many of them focused on stratospheric climate forcings, to assess the relative influence of tropospheric and stratospheric climate change on the extratropical circulation indices (Arctic Oscillation, AO; North Atlantic Oscillation, NAO). The experiments are run in two different ways: with variable sea surface temperatures (SSTs) to allow for a full tropospheric climate response, and with specified SSTs to minimize the tropospheric change. The results show that tropospheric warming (cooling) experiments and stratospheric cooling (warming) experiments produce more positive (negative) AO/NAO indices. For the typical magnitudes of tropospheric and stratospheric climate changes, the tropospheric response dominates; results are strongest when the tropospheric and stratospheric influences are producing similar phase changes. Both regions produce their effect primarily by altering wave propagation and angular momentum transports, but planetary wave energy changes accompanying tropospheric climate change are also important. Stratospheric forcing has a larger impact on the NAO than on the AO, and the angular momentum transport changes associated with it peak in the upper troposphere, affecting all wavenumbers. Tropospheric climate changes influence both the A0 and NAO with effects that extend throughout the troposphere. For both forcings there is often vertical consistency in the sign of the momentum transport changes, obscuring the difference between direct and indirect mechanisms for influencing the surface circulation.

ASSOCIATIONS BETWEEN NAO VARIBILITY AND U.S. MID-ATLANTIC REGION HYDROCLIMATOLOGY

EPA Science Inventory

Variability in the climate of the US Mid-Atlantic Region is associated with larger scale variability in the El Nino-Southern Oscillation (ENSO), the Pacific North American (PNA) teleconnection pattern, and the North Atlantic Oscillation (NAO). Collectively, these three large-scal...

New Insights into the Instability of Discharge Products in Na-O2 Batteries.

PubMed

Landa-Medrano, Imanol; Pinedo, Ricardo; Bi, Xuanxuan; Ruiz de Larramendi, Idoia; Lezama, Luis; Janek, Jürgen; Amine, Khalil; Lu, Jun; Rojo, Teófilo

2016-08-10

Sodium-oxygen batteries currently stimulate extensive research due to their high theoretical energy density and improved operational stability when compared to lithium-oxygen batteries. Cell stability, however, needs to be demonstrated also under resting conditions before future implementation of these batteries. In this work we analyze the effect of resting periods on the stability of the sodium superoxide (NaO2) discharge product. The instability of NaO2 in the cell environment is demonstrated leading to the evolution of oxygen during the resting period and the decrease of the cell efficiency. In addition, migration of the superoxide anion (O2(-)) in the electrolyte is observed and demonstrated to be an important factor affecting Coulombic efficiency.

Radio Meteors Observations Techniques at RI NAO

NASA Astrophysics Data System (ADS)

Vovk, Vasyl; Kaliuzhnyi, Mykola

2016-07-01

The Solar system is inhabited with large number of celestial bodies. Some of them are well studied, such as planets and vast majority of big asteroids and comets. There is one group of objects which has received little attention. That is meteoroids with related to them meteors. Nowadays enough low-technology high-efficiency radio-technical solutions are appeared which allow to observe meteors daily. At RI NAO three methodologies for meteor observation are developed: single-station method using FM-receiver, correlation method using FM-receiver and Internet resources, and single-station method using low-cost SDR-receiver.

High-Capacity Sodium Peroxide Based NaO 2 Batteries with Low Charge Overpotential via a Nanostructured Catalytic Cathode

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ma, Lu; Zhang, Dongzhou; Lei, Yu

The superoxide based Na-O-2 battery has circumvented the issue of large charge overpotential in Li-O-2 batteries; however, the one-electron process leads to limited capacity. Herein, a sodium peroxide based low-overpotential (similar to 0.5 V) Na-O-2 battery with a capacity as high as 7.5 mAh/cm(2) is developed with Pd nanoparticles as catalysts on the cathode.

Pharmacokinetics and efficiency of brain targeting of ginsenosides Rg1 and Rb1 given as Nao-Qing microemulsion.

PubMed

Li, Tao; Shu, Ya-Jun; Cheng, Jia-Yin; Liang, Run-Cheng; Dian, Shao-Na; Lv, Xiao-Xun; Yang, Meng-Qi; Huang, Shu-Ling; Chen, Gang; Yang, Fan

2015-02-01

Nao-Qing solution has been shown to be clinically effective in the treatment of acute ischemic stroke (AIS). The purpose of this study was to improve the pharmacokinetics and brain uptake of Nao-Qing, administered as an oil-in-water microemulsion. Sprague-Dawley (SD) rats were given Nao-Qing microemulsion by intranasal or intragastric routes. Samples of blood, brain, heart, liver, lung and kidney were collected at pre-determined time intervals, and the contents of ginsenosides Rg1 and Rb1 (active ingredients of the Nao-Qing microemulsion) were analyzed by high-performance liquid chromatography (HPLC). The results showed that contents of ginsenosides Rg1 and Rb1 in Nao-Qing microemulsion was 8475.13 ± 54.61 μg/ml and 6633.42 ± 527.27 μg/ml, respectively, and that the particle size, pH and viscosity of the microemulsion were 19.9 ± 5.07 nm, 6.1 and 3.056 × 10(-3 )Pas, respectively. Absorption of ginsenoside Rg1 was higher than that of ginsenoside Rb1, which was barely detectable after intragastric administration; furthermore, the concentration of ginsenoside Rg1 in blood and other tissues at each time point was lower for intragastric than for intranasal administration. Compared with intragastric administration, intranasal administration resulted in a shorter tmax (0.08 versus 1 h), a higher Cmax (16.65 versus 11.29 μg/ml), and a higher area under the concentration-time curve (AUC) (592.91 versus 101.70 μgċh/ml) in the brain. The relative rates of uptake (Re) and the ratio of peak concentration (Ce) in the brain were 126.31% and 147.48% for ginsenoside Rg1, respectively. These data illustrate that intranasal administration can promote the absorption of drugs in Nao-Qing microemulsion and achieve fast effect.

Breakdown of NAO reproducibility into internal versus externally-forced components: a two-tier pilot study

NASA Astrophysics Data System (ADS)

Douville, Hervé; Ribes, A.; Tyteca, S.

2018-03-01

Assessing the ability of atmospheric models to capture observed climate variations when driven by observed sea surface temperature (SST), sea ice concentration (SIC) and radiative forcings is a prerequisite for the feasibility of near term climate predictions. Here we achieve ensembles of global atmospheric simulations to assess and attribute the reproducibility of the boreal winter atmospheric circulation against the European Centre for Medium Range Forecasts (ECMWF) twentieth century reanalysis (ERA20C). Our control experiment is driven by the observed SST/SIC from the Atmospheric Model Intercomparison Project. It is compared to a similar ensemble performed with the ECMWF model as a first step toward ERA20C. Moreover, a two-tier methodology is used to disentangle externally-forced versus internal variations in the observed SST/SIC boundary conditions and run additional ensembles allowing us to attribute the observed atmospheric variability. The focus is mainly on the North Atlantic Oscillation (NAO) variability which is more reproducible in our model than in the ECMWF model. This result is partly due to the simulation of a positive NAO trend across the full 1920-2014 integration period. In line with former studies, this trend might be mediated by a circumglobal teleconnection mechanism triggered by increasing precipitation over the tropical Indian Ocean (TIO). Surprisingly, this response is mainly related to the internal SST variability and is not found in the ECMWF model driven by an alternative SST dataset showing a weaker TIO warming in the first half of the twentieth century. Our results may reconcile the twentieth century observations with the twenty-first century projections of the NAO. They should be however considered with caution given the limited size of our ensembles, the possible influence of other sources of NAO variability, and the uncertainties in the tropical SST trend and breakdown between internal versus externally-forced variability.

[The Spanish strategy for nutrition, physical activity and the prevention of obesity (NAOS Strategy)].

PubMed

Ballesteros Arribas, Juan Manuel; Dal-Re Saavedra, Marián; Pérez-Farinós, Napoleón; Villar Villalba, Carmen

2007-01-01

Obesity, the prevalence of which is still on the rise, is related to the main chronic diseases affecting the health of the population. Therefore, in 2004, the World Health Assembly approved the Global Strategy on Diet, Physical Activity and Health with the aim of reducing the risk factors of nontransmittable diseases related to unhealthy diets and physical inactivity. Along this same line, the Spanish Ministry of Health and Consumer Affairs began implementing the NAOS Strategy in 2005 as a platform from which to include and promote all those initiatives contributing to achieving the necessary social change in the promotion of healthy eating and the prevention of a sedentary lifestyle by meeting certain specific challenges within different scopes of action. The NAOS Strategy extends far beyond the healthcare and educational areas, by combining actions in all those sectors of society playing a role in preventing obesity. Informative campaigns, agreements with public and private institutions, voluntary working agreements, educational programs and supporting health promotion initiatives are some of the activities being carried out as part of the NAOS Strategy. Carrying out these activities and incorporating yet others, in conjunction with the work of evaluating and monitoring all of these activities, will be what is going to make it possible to maintain a high degree of effectiveness in preventing obesity.

Augmentation effect of acupuncture on Bi'nao for hypophasis in patients with Bell's palsy: study protocol for a randomized controlled trial.

PubMed

Li, Xiaoyan; Chen, Chunlan; Zhao, Chuang; Li, Zunyuan; Liang, Wei; Liu, Zhidan

2018-06-11

Hypophasis is one of the most frequently observed sequelae of patients with Bell's palsy, who have not recovered completely, creating a clinical difficulty for physicians. Acupuncture therapy has been widely used to treat Bell's palsy as a reasonable resolution for management of symptoms such as hypophasis. The number of acupuncture points (acu-points) is frequently selected in the approach of acupuncture therapy; however, whether these had high efficiency has not been proved. According to the literature review, Bi'nao was useful for treating eye and eye lipid diseases, which could be proved only by some successful cases. Thus, a randomized controlled trial was designed to evaluate the efficiency of the acu-point Bi'nao. Participants with hypophasis as the major symptom are selected among patients with Bell's palsy and randomly allocated into one of the three groups at a 1:1:1 allocation ratio. All participants receive conventional acupuncture therapy; however, those assigned to the real acupuncture group will be given added acupuncture therapy on the acu-point Bi'nao, while those assigned to the sham acupuncture group were given extra acupuncture therapy on the sham Bi'nao as a placebo. The efficacy of the acupuncture therapy on the acu-point Bi'nao for hypophasis will be evaluated by Eye Crack Width Measurement (ECWM) and Eyelid Strength Assessment (ESA) before and after therapy. This is the first study assessing the safety and efficiency of Bi'nao in treating the hypophasis of patients with Bell's palsy that might support the application of this acupuncture therapy. However, evaluating hypophasis is challenging, and, thus, ECWM and ESA were applied to measure the eyelid movement. Chinese Clinical Trials Registry, ChiCTR-INR-17012955 . Registered on 12 October 2017.

AO/NAO Response to Climate Change. 2; Relative Importance of Low- and High-Latitude Temperature Changes

NASA Technical Reports Server (NTRS)

Rind, D.; Perlwitz, J.; Lonergan, P.; Lerner, J.

2005-01-01

Using a variety of GCM experiments with various versions of the GISS model, we investigate how different aspects of tropospheric climate changes affect the extratropical Arctic Oscillation (AO)/North Atlantic Oscillation (NAO) circulation indices. The results show that low altitude changes in the extratropical latitudinal temperature gradient can have a strong impact on eddy forcing of the extratropical zonal wind, in the sense that when this latitudinal temperature gradient increases, it helps force a more negative AO/NAO phase. In addition, local conditions at high latitudes can stabilize/destabilize the atmosphere, inducing negative/positive phase changes. To the extent that there is not a large temperature change in the tropical upper troposphere (either through reduced tropical sensitivity at the surface, or limited transport of this change to high levels), the changes in the low level temperature gradient can provide the dominate influence on the extratropical circulation, so that planetary wave meridional refraction and eddy angular momentum transport changes become uncorrelated with potential vorticity transports. In particular, the climate change that produces the most positive NAO phase change would have substantial warming in the tropical upper troposphere over the Pacific Ocean, with high latitude warming in the North Atlantic. An increase in positive phase of these circulation indices is still more likely than not, but it will depend on the degree of tropical and high latitude temperature response and the transport of low level warming into the upper troposphere. These are aspects that currently differ among the models used for predicting the effects of global warning, contributing to the lack of consensus of future changes in the AO/NAO.

GIS-based Stress Field Modeling of the North Arm of Sulawesi (NAoS) and its application in mineral prospectivity assessment

NASA Astrophysics Data System (ADS)

Albert, Gáspár; Szentpéteri, Krisztián

2017-04-01

Remotely sensed and digital map data are useful sources for regional structural analysis, including stress calculations. If the type of a given fault is determined and is considered as Andersonian, and rather juvenile instead of a reactivated one, the tectonic stress can be calculated for each of the fault segments (Albert et al. 2016). The North Arm of Sulawesi, a west-east-trending land strip of the irregular shaped Sulawesi Island, is actively deforming and the upper plate tectonic setting is quite complex in this region since it is situated above a triple junction of the Eurasian, Pacific and Australian plates. The stress currently acting in this region not only creates neotectonics but triggers subduction-related volcanism shifting from west to east on the peninsula. The volcanic centers - adjacent to transfer faults and the colliding plates at depth - appear to be the most productive areas for epithermal-porphyry mineralization systems of economic potential (Szentpéteri et al. 2015). In this work we demonstrate how the derived stress field model helps to understand the location and clustering of various mineralization types in the NAoS. We examine if this method is applicable for mineral prospectively assessments. References Albert, G., Barancsuk, Á., and Szentpéteri, K., 2016, Stress field modelling from digital geological map data: Geophysical Research Abstracts, v. 18, EGU2016-14565. Szentpéteri, K., Albert, G., and Ungvári, Z., Plate tectonic - and stress field - modeling of the North Arm of Sulawesi, Indonesia, to better understand distribution of mineral deposits styles., in Proceedings SEG 2015 I World Class Ore Deposits: Discovery to Recovery, Wrest Point Convention Centre, Hobart, Australia, September 27 - 30. 2015.

Serial clustering of extratropical cyclones and relationship with NAO and jet intensity based on the IMILAST cyclone database

NASA Astrophysics Data System (ADS)

Ulbrich, Sven; Pinto, Joaquim G.; Economou, Theodoros; Stephenson, David B.; Karremann, Melanie K.; Shaffrey, Len C.

2017-04-01

Cyclone families are a frequent synoptic weather feature in the Euro-Atlantic area, particularly during wintertime. Given appropriate large-scale conditions, such series (clusters) of storms may cause large socio-economic impacts and cumulative losses. Recent studies analyzing reanalysis data using single cyclone tracking methods have shown that serial clustering of cyclones occurs on both flanks and downstream regions of the North Atlantic storm track. Based on winter (DJF) cyclone counts from the IMILAST cyclone database, we explore the representation of serial clustering in the ERA-Interim period and its relationship with the NAO-phase and jet intensity. With this aim, clustering is estimated by the dispersion of winter (DJF) cyclone passages for each grid point over the Euro-Atlantic area. Results indicate that clustering over the Eastern North Atlantic and Western Europe can be identified for all methods, although the exact location and the dispersion magnitude may vary. The relationship between clustering and (i) the NAO-phase and (ii) jet intensity over the North Atlantic is statistically evaluated. Results show that the NAO-index and the jet intensity show a strong contribution to clustering, even though some spread is found between methods. We conclude that the general features of clustering of extratropical cyclones over the North Atlantic and Western Europe are robust to the choice of tracking method. The same is true for the influence of the NAO and jet intensity on cyclone dispersion.

Late Holocene forest dynamics in the Gulf of Gaeta (central Mediterranean) in relation to NAO variability and human impact

NASA Astrophysics Data System (ADS)

Di Rita, Federico; Lirer, Fabrizio; Bonomo, Sergio; Cascella, Antonio; Ferraro, Luciana; Florindo, Fabio; Insinga, Donatella Domenica; Lurcock, Pontus Conrad; Margaritelli, Giulia; Petrosino, Paola; Rettori, Roberto; Vallefuoco, Mattia; Magri, Donatella

2018-01-01

A new high-resolution pollen record, spanning the last five millennia, is presented from the Gulf of Gaeta (Tyrrhenian Sea, central Italy), with the aim of verifying if any vegetation change occurred in the central Mediterranean region in relation to specific well-known global and/or regional climate events, including the 4.2 ka event, the Medieval Climate Anomaly (MCA) and the Little Ice Age (LIA), and to detect possible vegetation changes related to still under-investigated climate signals, for example the so-called "Bond 2" cold event around 2.8 ka BP. The vegetation dynamics of the Gaeta record shows a recurrent pattern of forest increase and decline punctuating the mid- and late Holocene. When the timing of these patterns is compared with the climate proxy data available from the same core (planktonic foraminifera assemblages and oxygen stable isotope record) and with the NAO (North Atlantic Oscillation) index, it clearly appears that the main driver for the forest fluctuations is climate, which may even overshadow the effects of human activity. We have found a clear correspondence between phases with negative NAO index and forest declines. In particular, around 4200 cal BP, a drop in AP (Arboreal Pollen) confirms the clearance recorded in many sites in Italy south of 43°N. Around 2800 cal BP, a vegetation change towards open conditions is found at a time when the NAO index clearly shows negative values. Between 800 and 1000 AD, a remarkable forest decline, coeval with a decrease in the frequencies of both Castanea and Olea, matches a shift in the oxygen isotope record towards positive values, indicating cooler temperatures, and a negative NAO. Between 1400-1850 AD, in the time period chronologically corresponding to the LIA (Little Ice Age), the Gaeta record shows a clear decline of the forest cover, particularly evident after 1550 AD, once again in correspondence with negative NAO index.

The Role of the North Atlantic Oscillation (NAO) on Recent Greenland Surface Mass Loss and Mass Partitioning

NASA Astrophysics Data System (ADS)

Tedesco, M.; Alexander, P.; Porter, D. F.; Fettweis, X.; Luthcke, S. B.; Mote, T. L.; Rennermalm, A.; Hanna, E.

2017-12-01

Despite recent changes in Greenland surface mass losses and atmospheric circulation over the Arctic, little attention has been given to the potential role of large-scale atmospheric processes on the spatial and temporal variability of mass loss and partitioning of the GrIS mass loss. Using a combination of satellite gravimetry measurements, outputs of the MAR regional climate model and reanalysis data, we show that changes in atmospheric patterns since 2013 over the North Atlantic region of the Arctic (NAA) modulate total mass loss trends over Greenland together with the spatial and temporal distribution of mass loss partitioning. For example, during the 2002 - 2012 period, melting persistently increased, especially along the west coast, as a consequence of increased insulation and negative NAO conditions characterizing that period. Starting in 2013, runoff along the west coast decreased while snowfall increased substantially, when NAO turned to a more neutral/positive state. Modeled surface mass balance terms since 1950 indicate that part of the GRACE-period, specifically the period between 2002 and 2012, was exceptional in terms of snowfall over the east and northeast regions. During that period snowfall trend decreased to almost 0 Gt/yr from a long-term increasing trend, which presumed again in 2013. To identify the potential impact of atmospheric patterns on mass balance and its partitioning, we studied the spatial and temporal correlations between NAO and snowfall/runoff. Our results indicate that the correlation between summer snowfall and NAO is not stable during the 1950 - 2015 period. We further looked at changes in patterns of circulation using self organizing maps (SOMs) to identify the atmospheric patterns characterizing snowfall during different periods. We discuss potential implications for past changes and future GCM and RCM simulations.

East Atlantic (EA) and North Atlantic Oscillation (NAO) interplay over the Iberian Peninsula for the last two millennia

NASA Astrophysics Data System (ADS)

Hernandez, A.; Sánchez-López, G.; Pla-Rabes, S.; Trigo, R.; Toro, M.; Granados, I.; Sáez, A.; Masque, P.; Pueyo, J. J.; Rubio-Inglés, M. J.; Giralt, S.

2016-12-01

The multi-proxy approach from sediments of an Iberian alpine lake allowed us to establish the climatic conditions in the Iberian Central Range (ICR) over the last two millennia. The comparison with other Iberian reconstructions permitted to identify possible forcing climate mechanisms. Climatic conditions would be transmitted to the sediments via the frequency of intense run-off events, derived from rain-on-snow events, and the lake productivity, ruled by ice-cover duration. The early Roman Period (RP; 200 BC - 350 AD) in the ICR was characterized by oscillations of intense run-off events, as a consequence of an alternation between cold and warm periods. From the second half of the RP to the onset of the Early Middle Ages (EMA; 350 - 500 AD) an increase in the intense run-off events suggests warm conditions, although a noticeable decrease during the rest of the EMA (500 - 900 AD) evidences a shift to very cold temperatures in this region. In terms of humidity, both RP and EMA climatic periods displayed a transition from a dry to a wet scenario that led to a decrease in lake productivity. These climatic conditions have been registered by other reconstructions in the Iberian Peninsula (IP), and a North-South humidity gradient could be envisaged, although spatial climatic discrepancies were significant. Precipitation and temperature in the IP present a more homogeneous spatial pattern when the NAO and EA modes have the same sign than when they have the opposite sign. Hence, a predominance of periods with NAO - EA in opposite phases could explain the climatic spatial heterogeneity in the IP during these two periods. The Medieval Climate Anomaly (MCA; 900 - 1300 AD) in the ICR was characterized by warm and dry conditions represented by an increase in exceptional run-off episodes and lake productivity whereas the Little Ice Age (LIA; 1300 - 1850 AD) showed the opposite scenario. Similar climatic conditions were registered in all the IP, reflecting a spatial climatic

Re-emerging ocean temperature anomalies in late-2010 associated with a repeat negative NAO

NASA Astrophysics Data System (ADS)

Taws, Sarah L.; Marsh, Robert; Wells, Neil C.; Hirschi, Joël

2011-10-01

Northern Europe was influenced by consecutive episodes of extreme winter weather at the start and end of the 2010 calendar year. A tripole pattern in North Atlantic sea surface temperature anomalies (SSTAs), associated with an exceptionally negative phase of the North Atlantic Oscillation (NAO), characterized both winter periods. This pattern was largely absent at the surface during the 2010 summer season; however equivalent sub-surface temperature anomalies were preserved within the seasonal thermocline throughout the year. Here, we present evidence for the re-emergence of late-winter 2009/10 SSTAs during the following early winter season of 2010/11. The observed re-emergence contributes toward the winter-to-winter persistence of the anomalous tripole pattern. Considering the active influence of the oceans upon leading modes of atmospheric circulation over seasonal timescales, associated with the memory of large-scale sea surface temperature anomaly patterns, the re-emergence of remnant temperature anomalies may have also contributed toward the persistence of a negative winter NAO, and the recurrence of extreme wintry conditions over the initial 2010/11 winter season.

Subregional precipitation climate of the Caribbean and relationships with ENSO and NAO

NASA Astrophysics Data System (ADS)

Jury, Mark; Malmgren, BjöRn A.; Winter, Amos

2007-08-01

Thirty-five meteorological stations encompassing the Caribbean region (Cuba, Bahamas, Jamaica, Dominican Republic, Puerto Rico, US Virgin Islands, St. Maarten, and Barbados) were analyzed over the time interval 1951-1981 to assess regional precipitation patterns and their relationships with the North Atlantic Oscillation (NAO) and El Niño-Southern Oscillation (ENSO). Application of factor analysis to these series revealed the existence of four geographically distinct precipitation regions, (C1) western Cuba and northwestern Bahamas, (C2) Jamaica, eastern Cuba, and southeastern Bahamas, (C3) Dominican Republic and northwestern Puerto Rico, and (C4) eastern Puerto Rico, US Virgin Islands, St. Maarten, and Barbados. This regionalization is related to different annual cycles and interannual fluctuations of rainfall. The annual cycle is more unimodal and largest in the northwest Caribbean (C1) and becomes increasingly bimodal toward lower latitudes (C4) as expected. Year-to-year variations of precipitation are compared with two well-known climatic indices. The ENSO relationship, represented by Niño 3.4 sea surface temperatures (SST), is positive and stable at all lags, but tends to reverse over the SE Caribbean (C4) in late summer. The NAO influence is weak and seasonally dependent. Early summer rainfall in the northwest Caribbean (C1) increases under El Niño conditions. Clusters 2 and 3 are less influenced by the global predictors and more regional in character.

Influence of winter NAO pattern on variable renewable energies potential in Europe over the 20th century

NASA Astrophysics Data System (ADS)

François, Baptiste; Raynaud, Damien; Hingray, Benoit; Creutin, Jean-Dominique

2017-04-01

Integration of Variable Renewable Energy (VRE) sources in the electricity system is a challenge because of temporal and spatial fluctuations of their power generation resulting from their driving weather variables (i.e. solar radiation wind speed, precipitation, and temperature). Very few attention was paid to low frequency variability (i.e. from annual to decades) even though it may have significant impact on energy system and energy market Following the current increase in electricity supplied by VRE generation, one could ask the question about the risk of ending up in a situation in which the level of production of one or more VRE is exceptionally low or exceptionally high for a long period of time and/or over a large area. What would be the risk for an investor if the return on investment has been calculated on a high energy production period? What would be the cost in term of carbon emission whether the system manager needs to turn on coal power plant to satisfy the demand? Such dramatic events would definitely impact future stakeholder decision to invest in a particular energy source or another. Weather low frequency variability is mainly governed by large-scale teleconnection patterns impacting the climate at global scale such as El Niño - Southern Oscillation (ENSO) in the tropics and in North America or the North Atlantic Oscillation (hereafter, NAO) in North America and Europe. Teleconnection pattern's influence on weather variability cascades to VRE variability and ends up by impacting electricity system. The aim of this study is to analysis the impact of the NAO on VRE generation in Europe during the winter season. The analysis is carried out over the twentieth century (i.e. from 1900 to 2010), in order to take into account climate low frequency variability, and for a set of 12 regions covering a large range of climates in Europe. Weather variable time series are obtained by using the ERA20C reanalysis and the SCAMP model (Sequential Constructive

Revisiting Caveiro Lake sediment record: the Holocene NAO and AMO impact on Pico Island (Azores archipelago)

NASA Astrophysics Data System (ADS)

Hernandez, A.; Giralt, S.; Raposeiro, P. M.; Gonçalves, V. M.; Pueyo, J. J.; Trigo, R. M.; Bao, R.; Sáez, A.

2017-12-01

Northern Hemisphere climate is partly conditioned by a number of atmospheric and oceanic patterns which occur in the North Atlantic sector. The favourable location of the Azores Archipelago (37°-40° N, 25°-31° W) results in a privileged place to generate high-resolution Holocene climatic proxy data that can contribute to deep our understanding on the evolution of these atmospheric and oceanic patterns. In the frame of three research projects, namely PALEONAO (CGL2010-15767), RAPIDNAO (CGL2013-40608-R) and PALEOMODES (CGL2016-75281-C2), high-resolution proxy-based reconstructions from Azores Archipelago have recently shown a combined impact of atmospheric and oceanic patterns at multiannual and decadal time-scales (Rubio-Inglés et al. 2016; Hernández et al. 2017). However, the long-term evolution coupling/uncoupling of these patterns is not well-determined yet. Here, we present a new high-resolution climate reconstruction based on the Caveiro Lake sedimentary sequence in order to fill this gap. Previously, Björck et al. (2006) studied a section of this sequence (the uppermost 4.6 m covering last 6 Ka cal BP) concluding that changes in the thermohaline circulation and the SST were the main drivers in the long-term precipitation variability, whereas the NAO impact was the main atmospheric driver of short-term precipitation changes. However, they only distinguished the NAO impact for the last 600 years owing to the low resolution of the study for the lower portion of the core. The new studied sequence (8.40 m long, 8.2 Ka cal BP) has been analysed at decadal-to centennial time-scale resolution for X-ray diffraction (XRD), X-ray fluorescence (XRF) core scanning and elemental and isotope geochemistry on bulk organic matter. The statistical multivariate analysis of the data highlights the main drivers triggering the sedimentary infill of the lake would be the NAO and AMO by controlling the lacustrine productivity via nutrients input. This new high

The role of the NAO on the North Atlantic hydrological conditions and its interplay with the EA and SCAND atmospheric patterns

NASA Astrophysics Data System (ADS)

Hernandez, A.; Rubio-Ingles, M. J.; Shanahan, T. M.; Sáez, A.; Raposeiro, P. M.; Vázquez-Loureiro, D.; Sánchez-López, G.; Gonçalves, V. M.; Bao, R.; Trigo, R.; Giralt, S.

2016-12-01

The NAO is the main atmospheric circulation mode controlling the largest fraction of the North Atlantic climate variability. It is defined by the normalized air pressure difference between the Azores High and the Iceland Low as the southern and northern centers of action of the dipole respectively. The NAO pattern has large influence over the precipitation regime in the North Atlantic and the western facade of Europe. Thus, the Lake Azul (São Miguel island, Azores archipelago), with a strategic location in the middle of the north Atlantic Ocean, is influenced by variations on intensity and position of the southern NAO center of action. The reconstruction of the past hydrological conditions in lake location for the last 700 years was obtained by means of high resolution δD plant leaf wax analyses, a proxy for the Precipitation/Evaporation ratio. The 700 years of climatic history included the end of the Medieval Climate Anomaly (MCA), the Little Ice Age (LIA) and the modern Global Warming (GW). The hydrological results showed multidecadal variations with no particular conditions at any climatic period. Overall, the MCA (1285 - 1350 AD) displayed mostly dry conditions, the LIA (1350 - 1820 AD) was mainly wet and, the last 200 years of record showed highly variable conditions. The lake Azul hydrological variations have been compared with a wide range of additional proxy datasets, including: documentary, ice, tree rings, speleothem, lacustrine and oceanic records from the North Atlantic. This comparison has allowed us to understand the decadal and centennial imprints of the NAO as well as to infer its interaction with other relevant large-scale circulation patterns over this sector, such as the Eastern Atlantic (EA) and the Scandinavian (SCAND) climate modes.

In Situ Imaging the Oxygen Reduction Reactions of Solid State Na-O2 Batteries with CuO Nanowires as the Air Cathode.

PubMed

Liu, Qiunan; Yang, Tingting; Du, Congcong; Tang, Yongfu; Sun, Yong; Jia, Peng; Chen, Jingzhao; Ye, Hongjun; Shen, Tongde; Peng, Qiuming; Zhang, Liqiang; Huang, Jianyu

2018-06-13

We report real time imaging of the oxygen reduction reactions (ORRs) in all solid state sodium oxygen batteries (SOBs) with CuO nanowires (NWs) as the air cathode in an aberration-corrected environmental transmission electron microscope under an oxygen environment. The ORR occurred in a distinct two-step reaction, namely, a first conversion reaction followed by a second multiple ORR. In the former, CuO was first converted to Cu 2 O and then to Cu; in the latter, NaO 2 formed first, followed by its disproportionation to Na 2 O 2 and O 2 . Concurrent with the two distinct electrochemical reactions, the CuO NWs experienced multiple consecutive large volume expansions. It is evident that the freshly formed ultrafine-grained Cu in the conversion reaction catalyzed the latter one-electron-transfer ORR, leading to the formation of NaO 2 . Remarkably, no carbonate formation was detected in the oxygen cathode after cycling due to the absence of carbon source in the whole battery setup. These results provide fundamental understanding into the oxygen chemistry in the carbonless air cathode in all solid state Na-O 2 batteries.

How Does Mediterranean Basin's Atmosphere Become Weak Moisture Source During Negative Phase of NAO: Use of AIRS, AMSR, TOVS, & TRMM Satellite Datasets Over Last Two NAO Cycles to Examine Governing Controls on E-P

NASA Technical Reports Server (NTRS)

Smith, Eric A.; Mehta, Amita V.

2008-01-01

The Mediterranean Sea is a noted 'concentration" basin in that it almost continuously exhibits positive evaporation minus precipitation (E - P ) properties -- throughout the four seasons and from one year to the next. Nonetheless, according to the ECMWF Era-40 48-year (1958-2005) climate reanalysis dataset, for various phases of the North Atlantic Oscillation (NAO) when the pressure gradient between Portugal and Iceland becomes either very relaxed (large negative NAO-Index) or in transition (small positive or negative NAO-Index), the atmospheric moisture source properties of the basin become weak, at times even reversed for several months (i.e., negative E - P). This behavior poses numerous questions concerning how and why these events occur. Moreover, it begs the question of what it would take for the basin to reach its tipping point in which P would exceed E throughout the rainy season (some six months) on an annually persistent basis -- and the sea would possibly transform to a recurring "dilution" basin. This talk investigates these questions by: (1) establishing over a period from 1979 to present, based on detailed analyses of satellite retrieval products from a combination of NASA-AQUA, NOAA-LEO, NASA/JAXA Scatterometer, and NASA-TRMM platforms, plus additional specialized satellite data products and ancillary meteorological datasets, the actual observation-based behavior of E - P, (2) diagnosing the salient physical and meteorological mechanisms that lead to the weaker E - P events during the analysis period, partly based on analyzing surface and upper air data at discrete stations in the western and eastern Mediterranean -- while at the same time evaluating the quality of the ERA-40 data over this same time period, (3) conducting GCM and high-resolution regional modeling experiments to determine if perturbed but realistic meteorological background conditions could maintain Mediterranean as a "dilution" basin through the October to March rainy season on

Barents-Kara sea ice and the winter NAO in the DePreSys3 Met Office Seasonal forecast model

NASA Astrophysics Data System (ADS)

Warner, J.; Screen, J.

2017-12-01

Accurate seasonal forecasting leads to a wide range of socio-economic benefits and increases resilience to prolonged bouts of extreme weather. This work looks at how November Barents-Kara sea ice may affect the winter northern hemisphere atmospheric circulation, using various compositing methods in the DePreSys3 ensemble model, with lag to argue better a relationship between the two. In particular, the NAO (North Atlantic Oscillation) is focused on given its implications on European weather. Using this large hindcast dataset comprised of 35 years with 30 available ensemble members, it is found that low Barents-Kara sea ice leads to a negative NAO tendency in all composite methods, with increased mean sea level pressure in higher latitudes. The significance of this varies between composites. This is preliminary analysis of a larger PhD project to further understand how Arctic Sea ice may play a role in seasonal forecasting skill through its connection/influence on mid-latitude weather.

Sub-regional Precipitation Climate of the Caribbean and Relationships With ENSO and NAO

NASA Astrophysics Data System (ADS)

Winter, A.; Jury, M.; Malmgren, B.

2006-12-01

Thirty-five meteorological stations encompassing the Caribbean region (Cuba, Bahamas, Jamaica, Dominican Republic, Puerto Rico, U.S. Virgin Islands, St. Maarten, and Barbados) were analyzed over the time interval 1951-1981 to assess regional precipitation patterns and their relationships with the North Atlantic Oscillation (NAO) and El Niño-Southern Oscillation (ENSO). Application of factor analysis to these series revealed the existence of four geographically distinct precipitation regions: (1) western Cuba and northwestern Bahamas, (2) Jamaica, eastern Cuba, and southeastern Bahamas, (3) Dominican Republic and northwestern Puerto Rico, and (4) eastern Puerto Rico, U.S. Virgin Islands, St. Marteen, and Barbados. This regionalization is related to different annual cycles and interannual fluctuations of rainfall. The annual cycle is unimodal and largest in the northwest Caribbean (1), and becomes increasingly bimodal toward lower latitudes (4) as expected. Year-to-year variations of precipitation are compared with two well known climatic indices. The ENSO relationship, represented by Niño3.4 SST, is positive and stable at all lags, but tends to reverse over the SE Caribbean (4) in late summer. The NAO influence is weak and seasonally dependent. Early summer rainfall in the northwest Caribbean (1) increases under El Niño conditions. Clusters 2 and 3 are less influenced by the global predictors and more regional in character. Previous related work sub-divided the Caribbean into two to three regions. Our work also shows that the main Caribbean basin should be divided into two clusters and not one homogeneous region as has previously been reported.

Variability modes of precipitation along a Central Mediterranean area and their relations with ENSO, NAO, and other climatic patterns

NASA Astrophysics Data System (ADS)

Kalimeris, Anastasios; Ranieri, Ezio; Founda, Dimitra; Norrant, Caroline

2017-12-01

This study analyses a century-long set of precipitation time series in the Central Mediterranean (encompassing the Greek Ionian and the Italian Puglia regions) and investigates the statistically significant modes of the interannual precipitation variability using efficient methods of spectral decomposition. The statistical relations and the possible physical couplings between the detected modes and the global or hemispheric patterns of climatic variability (the El Niño Southern Oscillation or ENSO, the North Atlantic Oscillation or NAO, the East Atlantic or EA, the Scandinavian or SCAND, and others) were examined in the time-frequency domain and low-order synchronization events were sought. Significant modes of precipitation variability were detected in the Taranto Gulf and the southern part of the Greek Ionian region at the sub-decadal scales (mostly driven by the SCAND pattern) and particularly at the decadal and quasi-decadal scales, where strong relations found with the ENSO activity (under complex implications of EA and NAO) prior to the 1930s or after the early-1970s. The precipitation variations in the Adriatic stations of Puglia are dominated by significant bi-decadal modes which found to be coherent with the ENSO activity and also weakly related with the Atlantic Ocean sea surface temperature intrinsic variability. Additionally, important discontinuities characterize the evolution of precipitation in certain stations of the Taranto Gulf and the Greek Ionian region during the early-1960s and particularly during the early-1970s, followed by significant reductions in the mean annual precipitation. These discontinuities seem to be associated with regional effects of NAO and SCAND, probably combined with the impact of the 1970s climatic shift in the Pacific and the ENSO variability.

The near-term prediction of drought and flooding conditions in the northeastern United States based on extreme phases of AMO and NAO

NASA Astrophysics Data System (ADS)

Berton, Rouzbeh; Driscoll, Charles T.; Adamowski, Jan F.

2017-10-01

A series of hydroclimatic teleconnection patterns were identified between variations in either Atlantic or Pacific oceanic indices with precipitation and discharge anomalies in the northeastern United States. We hypothesized that temporal annual or seasonal changes in discharge could be explained by variations in extreme phases of the Atlantic Multi-decadal Oscillation (AMO index, SST: Sea Surface Temperature anomalies) and the North Atlantic Oscillation (NAO index, SLP: Sea-Level Pressure anomalies) up to three seasons in advance. The Merrimack River watershed, the fourth largest basin in New England, with a drainage area of 13,000 km2, is a compelling study site because it not only provides an opportunity to investigate the teleconnection between hydrologic variables and large-scale climate circulation patterns, but also how those patterns may become obscured by anthropogenic disturbances such as river regulation or urban development. We considered precipitation and discharge data of 21 gauging stations within the Merrimack River watershed, including the Hubbard Brook Experimental Forest (HBEF), NH, with a median record length of 55 years beginning as early as 1904. The discharge anomalies were statistically significant (p-value ≤ 0.2) between extreme positive and negative phases of AMO (1857-2011) and NAO (1900-2011) and revealed the potential teleconnectivity of climate circulation patterns with discharge. Annual and seasonal correlations of discharge were examined with the extreme phases of AMO and NAO at zero-, one-, or two- year/season lags (total of 30 scenarios). When AMO was greater than 0.2, the strongest correlations of AMO and NAO with discharge were observed at headwater catchments. This correlation weakened downstream towards larger regulated and/or developed sub-basins. We introduced a simple approach for near-term prediction of drought and flooding events. An exponential decay function was regressed through the historic occurrence of the relative

Sea level trends and NAO influences: The Bristol Channel/Severn Estuary

NASA Astrophysics Data System (ADS)

Phillips, M. R.; Crisp, S.

2010-09-01

Fifteen years, 1993 (earliest available) to 2007 inclusive of monthly mean and extreme (maximum and minimum) sea level data were assessed for four tide gauges located in the Bristol Channel (Mumbles and Ilfracombe) and Severn Estuary (Newport and Hinkley Point). Results showed decreasing maximum sea level trends and increasing minimum sea level trends, resulting in convergence. However, maximum extreme sea levels on the Welsh shoreline (Mumbles and Newport) were higher than corresponding locations on the English coast (Ilfracombe and Hinkley Point). Analysis showed that from 1995 to 1998 inclusive, maximum extreme sea levels were significantly higher at Mumbles (t = 2.342; df = 10; p < 0.05), Newport (t = 5.034; df = 13; p < 0.01) and Hinkley Point (t = 3.570; df = 13; p < 0.01) and were correlated to increased storm frequencies during these years. However, Ilfracombe (t = 1.472; df = 12; p > 0.05) did not demonstrate similar significance, possibly due to tide gauge location and coastal aspect, while tidal influences became more dominant as the tidal prism moved up the estuary. Actual mean sea levels (MSL) at Newport (t = 2.880; df = 14; p < 0.05) and Hinkley Point (t = 5.282; df = 14; p < 0.01) were significantly higher than predicted; at Mumbles (t = 2.673; df = 11; p < 0.05) they were significantly lower than predicted; while Ilfracombe (t = 1.989; df = 13; p > 0.05) once again showed no significant difference. Mumbles is the only location with off-shore sand waves and analysis suggested these as the cause of opposite trends. Sea level variation was strongly correlated to the North Atlantic Oscillation (NAO) Index, especially for maximum extreme sea levels during positive phases (R 2 = 86%), and higher positive or negative NAO Index values resulted in larger sea level ranges. Further analysis showed a rising Bristol Channel and Severn Estuary MSL trend of 2.4 mm yr - 1 and a 2050 MSL of 0.370 m is projected to inform future management. However, continuous

The NAO Influence on the Early to Mid-Holocene North Atlantic Coastal Upwelling

NASA Astrophysics Data System (ADS)

Hernandez, A.; Cachão, M.; Sousa, P.; Trigo, R. M.; Freitas, M. C.

2017-12-01

Coastal upwelling regions yield some of the oceanic most productive ecosystems, being crucial for the worldwide social and economic development. Most upwelling systems, emerging cold nutrient-rich deep waters, are located in the eastern boundaries of the Atlantic and Pacific basins, and are driven by meridional wind fields parallel to the coastal shore. These winds are associated with the subsiding branch of the large-scale Anticyclonic high pressure systems that dominate the subtropical ocean basins, and therefore can be displaced or intensified within the context of past and future climate changes. However, the role of the current global warming influencing the coastal upwelling is, as yet, unclear. Therefore it is essential to derive a long-term perspective, beyond the era of instrumental measurements, to detect similar warm periods in the past that have triggered changes in the upwelling patterns. In this work, the upwelling dynamics in the Iberian North Atlantic margin during the early and mid-Holocene is reconstructed, using calcareous nannofossils from a decadally resolved estuarine sediment core located in southwestern Portugal. Results suggest that the coastal dynamics reflects changes in winds direction likely related to shifts in the NAO-like conditions. Furthermore, the reconstructed centennial-scale variations in the upwelling are synchronous with changes in solar irradiance, a major external forcing factor of the climate system that is known to exert influence in atmospheric circulation patterns. In addition, these proxy-based data interpretations are in agreement with wind field and solar irradiance simulation modelling for the mid-Holocene. Therefore, the conclusion that the solar activity via the NAO modulation controlled the North Atlantic upwelling of western Iberia during the early and mid-Holocene at decadal to centennial timescales can be derived. The financial support for attending this meeting was possible through FCT project UID/GEO/50019

Late Holocene Hydroclimate Variability of West-Central Guatemala Driven by NAO and ENSO

NASA Astrophysics Data System (ADS)

Stansell, N.; Feller, J. R.; Steinman, B. A.; Lachniet, M. S.; Shea, C.; Avendaño, C.

2016-12-01

Finely-laminated sediments from Lake San Francisco in the Huehuetenango province of west-central Guatemala provide a sub-decadal resolution record of hydroclimate variability spanning the last 5200 years. Age control is based on 7 radiocarbon samples of charcoal and lead-210 dating of surface sediments. Modern water isotope samples indicate the lake is currently an open system, and variations of δ18O values of precipitation in the region are driven largely by the amount effect. In contrast, a strong covariance of δ18O and δ13C values combined with pollen evidence in the lower part of the record suggests the lake was a seasonally closed-basin from 5200 to 3200 BP, and was sensitive to evaporation under more arid conditions. There was an overall trend of increasingly wetter conditions during the late Holocene, and a lack of covariance between δ18O and δ13C indicates that the lake transitioned to an open-basin after 3200 BP. The Medieval Climate Anomaly was the wettest period of the late Holocene, and there was a shift to lower precipitation amounts during the Little Ice Age. Present conditions are more arid than most of the last millennium, but δ18O values in the modern sediments are intermediate compared to the full late Holocene. The Lake San Francisco record provides additional evidence that the hydroclimate of Central America is sensitive to both changes in North Atlantic Oscillation (NAO) and the El Niño Southern Oscillation (ENSO). Drier conditions at San Francisco over the length of the record were associated with more negative phases of NAO and vice versa. During the last 1500 years, drier conditions at San Francisco were also associated with warmer sea-surface temperatures (SSTs) in the Niño3 region, and it was wetter when SSTs were colder.

Urban NO 2 and NO pollution in relation to the North Atlantic Oscillation NAO

NASA Astrophysics Data System (ADS)

Grundström, M.; Linderholm, H. W.; Klingberg, J.; Pleijel, H.

2011-02-01

The North Atlantic Oscillation (NAO), a measure of the strength of the zonal wind across the North Atlantic Ocean, strongly influences weather conditions in NW Europe, e.g. temperature, precipitation and wind, especially during winter. It was hypothesised that elevated concentrations of nitrogen oxides in Gothenburg would be enhanced during negative NAO index (NAOI) conditions, representing more anticyclonic weather situations and thus leading to limited air mixing in the urban atmosphere, than situations with NAOI > 0. Hourly wintertime (December-February) concentrations (1997-2006) of NO 2, NO, air pressure, temperature and wind direction from an urban rooftop (30 m above street level) in the centre of the City of Gothenburg were analysed in relation to NAOI. Air pressure, the average concentration of nitrogen oxides (NO x = NO 2 + NO), as well as the fraction of hourly NO 2 and NO concentrations exceeding 90 μg m -3 and the fraction of daily NO concentrations exceeding 60 μg m -3, were significantly and negatively related to NAOI. Air temperature was positively correlated with NAOI. Southerly and westerly winds were more common in months with positive NAOI, while easterly and northerly winds were overrepresented in months with negative NAOI. High pollution concentrations dominantly occurred in situations with northerly and easterly wind directions. High NO 2 and NO concentrations were associated with negative NAOI, especially in the morning when the traffic rush coincided with restricted air mixing. Over the ten-year period there were trends for more negative NAOI and increased time fractions with hourly NO 2 concentrations exceeding 90 μg m -3. The conclusion of this study is that a climate shift towards higher or lower NAOI has the potential to significantly influence urban air pollution in North-West Europe, and thus the possibility to reach air quality standards, even if emissions remain constant.

Preparation and characterization of novel nanocomposites of inorganic/polysaccharide type =

NASA Astrophysics Data System (ADS)

Oliveira, Fabiane Costa

O uso de polimeros naturais no ambito da preparacao de nanocompositos nao tem sido tao amplamente estudado quando comparado com os polimeros sinteticos. Assim, esta tese tem como objectivo estudar metodologias para a preparacao de novos materiais nanocompositos sob a forma de dispersoes e filmes utilizando polissacarideos como matriz. A tese esta dividida em cinco capitulos sendo o ultimo capitulo dedicado as conclusoes gerais e a sugestoes para trabalhos futuros. Inicialmente e apresentada uma breve revisao bibliografica sobre os principais temas colocando esta tese em contexto. Consideracoes sobre o uso de polimeros naturais e a sua combinacao com a utilizacao de nanoparticulas inorganicas para a fabricacao de novos bionanocomposites sao descritas e os objectivos e outline da tese sao tambem apresentados. No segundo capitulo, a preparacao de particulas de silica puras ou modificadas bem como a sua caracterizacao por FTIR, SEM, TEM, TGA, DLS (tamanho e potencial zeta) e medicoes de angulo de contacto sao discutidas. De modo a melhorar a compatibilidade da silica com os polissacarideos, as particulas SiO2 foram modificados com dois compostos do tipo organosilano: 3- metacril-oxipropil-trimetoxissilano (MPS) e 3-aminopropil-trimetoxissilano (APS). As particulas SiO2 MPS foram posteriormente encapsuladas com de poli(metacrilato de glicidilo) utilizando a tecnica de polimerizacao em emulsao. A utilizacao dos nanocompositos resultantes na preparacao de dispersoes de bionanocompositos nao foi bem sucedida e por esse motivo nao os estudos nao foram prosseguidos. O uso de SiO2 APS na preparacao de dispersoes bionanocomposite foi eficiente. No terceiro capitulo e apresentada uma revisao sobre dispersoes bionanocompositas e respectiva caracterizacao destacando aspectos fundamentais sobre reologia e microestrutura. Em seguida, e discutido o estudo sistematico realizado sobre o comportamento reologico de dispersoes de SiO2 utilizando tres polissacarideos distintos no que

Progress in Suppressing Scattered Light into the Optical Beam Path of the NAO Rozhen 2m Telescope

NASA Astrophysics Data System (ADS)

Ovcharov, E. P.; Petrov, N.; Markov, H.; Bonev, T.; Donchev, Z.

2010-09-01

In this poster paper we present a summary of the published analysis of the spatial dependence of the magnitudes derived from images obtained in the RC focal plane of the 2m RCC NAO Rozhen telescope. An alert for the possible reason was the unusually curved flat-field images taken as a part of the standard CCD calibration procedure. The reasons for the problem are described and a solution is presented, which consists modification of the mirror baffles and mounting of special diaphragm at the entrance of the filter wheel.

The influences of the AMO and NAO on the sedimentary infill in an Azores Archipelago lake since ca. 1350 CE

NASA Astrophysics Data System (ADS)

Hernández, Armand; Sáez, Alberto; Bao, Roberto; Raposeiro, Pedro M.; Trigo, Ricardo M.; Doolittle, Sara; Masqué, Pere; Rull, Valentí; Gonçalves, Vítor; Vázquez-Loureiro, David; Rubio-Inglés, María J.; Sánchez-López, Guiomar; Giralt, Santiago

2017-07-01

The location of the Azores Archipelago in the North Atlantic makes this group of islands an excellent setting to study the long-term behavior of large oceanic and atmospheric climate dynamic patterns, such as the Atlantic Multidecadal Oscillation (AMO) and the North Atlantic Oscillation (NAO). Here, we present the impacts of these patterns on Lake Empadadas (Azores Archipelago) from the Medieval Climate Anomaly (MCA) - Little Ice Age (LIA) transition to the present based on sedimentological, geochemical and biological characterizations of the sedimentary record. Multivariate analyses of a number of proxies including X-ray fluorescence (XRF), X-ray diffraction (XRD), total organic and inorganic carbon (TOC and TIC) and diatom life forms abundance reveal that the sedimentary infill evolution has been controlled by (i) fluctuations in the lake level and (ii) variations in organic matter accumulation. Both processes are governed by climate variability and modulated by anthropogenic activities associated with changes on the lake catchment. Changes in these two sedimentary processes have been used to infer five stages: (i) the MCA-LIA transition (ca. 1350-1450 CE) was characterized by a predominantly positive AMO phase, which led to intermediate lake levels and high organic matter concentration; (ii) the first half of the LIA (ca. 1450-1600 CE) was characterized by predominant lowstand conditions and intermediate organic matter deposition mainly related to negative AMO phases; (iii) the second half of the LIA (ca. 1600-1850 CE) was characterized by negative AMO and NAO phases, implying intermediate lake levels and high organic matter deposition; (iv) the Industrial era (ca. 1850-1980 CE) was characterized by the lowest lake level and organic matter accumulation associated with negative AMO phases; and (v) the period spanning between 1980 CE and the present reveals the highest lake levels and low organic matter deposition, being associated with very positive AMO

Detecting the Benefits of Shade Management in the Thermal Regime of an Upland River Under Positive and Negative Phases of the NAO

NASA Astrophysics Data System (ADS)

Wilby, R.; Johnson, M. F.

2017-12-01

Water temperature is an important determinant of river ecosystem function and health. Hence, there is growing concern about rising surface water temperatures as a consequence of global warming and human modifications to river regimes. Some agencies are advocating riparian shade management as a means of `keeping rivers cool'. As appealing as this policy might seem, there are a host of practical considerations such as which species to plant, where to plant, and how much to plant? Moreover, there can be unintended consequences for groundwater recharge, flood risk and nutrient fluxes through the buffer zone. The thermal benefits of tree-planting may also be hard to detect amidst the integrated, downstream effects of landscape shade and flows from springs. Yet, to truly evaluate shade management as an adaptation to climate change, clear evidence is needed of the costs and benefits of this local intervention. What has this got to do with natural modes of climate variability? Continental scale, hydrological impacts of ENSO, the PDO and NAO have been widely reported - these periodic variations in ocean-atmosphere circulations are often blamed for floods, droughts, wildfire, crop failures, and the like. But there is emerging evidence that such phenomena also drive inter-annual variations in the heat flux of rivers. This matters because the underlying signal can confound field and model experiments intended to test adaptation options. Here, we present evidence of NAO signatures in the water temperature regime of the River Dove, UK. We compare the amplitude of these thermal variations with the expected benefit of tree planting. We demonstrate that the difference in maximum summer water temperature between strongly positive and strongly negative NAO phases can be about 2.5°C. This is equivalent to the thermal benefit of more than 2 km of riparian shade for the river studied. So, whilst modes of climate variability undoubtedly have a global footprint, let us not forget that

Type II Cepheids: evidence for Na-O anticorrelation for BL Her type stars?

NASA Astrophysics Data System (ADS)

Kovtyukh, V.; Yegorova, I.; Andrievsky, S.; Korotin, S.; Saviane, I.; Lemasle, B.; Chekhonadskikh, F.; Belik, S.

2018-06-01

The chemical composition of 28 Population II Cepheids and one RR Lyrae variable has been studied using high-resolution spectra. The chemical composition of W Vir variable stars (with periods longer than 8 d) is typical for the halo and thick disc stars. However, the chemical composition of BL Her variables (with periods of 0.8-4 d) is drastically different, although it does not differ essentially from that of the stars belonging to globular clusters. In particular, the sodium overabundance ([Na/Fe] ≈ 0.4) is reported for most of these stars, and the Na-O anticorrelation is also possible. The evolutionary tracks for BL Her variables (with a progenitor mass value of 0.8 solar masses) indicate that mostly helium-overabundant stars (Y = 0.30-0.35) can fall into the instability strip region. We suppose that it is the helium overabundance that accounts not only for the existence of BL Her variable stars but also for the observed abnormalities in the chemical composition of this small group of pulsating variables.

The Na-O anticorrelation in horizontal branch stars. IV. M 22

NASA Astrophysics Data System (ADS)

Gratton, R. G.; Lucatello, S.; Sollima, A.; Carretta, E.; Bragaglia, A.; Momany, Y.; D'Orazi, V.; Cassisi, S.; Salaris, M.

2014-03-01

We obtained high-resolution spectra for 94 candidate stars belonging to the HB of M 22 with FLAMES. Previous works have indicated that this cluster has split subgiant (SGB) and red giant branches (RGB) and hosts two different stellar populations, differing in overall metal abundance and both exhibiting a Na-O anti-correlation. The HB stars we observed span a restricted temperature range (7800 < Teff < 11 000 K), where about 60% of the HB stars of M 22 are. Within our sample, we can distinguish three groups of stars segregated (though contiguous) in colours: Group 1 (49 stars) is metal-poor, N-normal, Na-poor, and O-rich: our abundances for this (cooler) group match those determined for the primordial group of RGB stars (a third of the total) from previous studies very well. Group 2 (23 stars) is still metal-poor, but it is N- and Na-rich, though only very mildly depleted in O. We can identify this intermediate group as the progeny of the metal-poor RGB stars that occupy an intermediate location along the Na-O anti-correlation and include about 10% of the RGB stars. The third group (20 stars) is metal-rich, Na-rich, and O-rich. This hotter group most likely corresponds to the most O-rich component of the previously found metal-rich RGB population (a quarter of the total). We did not observe any severely O-depleted stars and we think that the progeny of these stars falls on the hotter part of the HB. Furthermore, we found that the metal-rich population is also over-abundant in Sr, in agreement with results for corresponding RGB and SGB stars. However, we do not find any significant variation in the ratio between the sum of N and O abundances to Fe. We do not have C abundances for our stars. There is some evidence of an enhancement of He content for Groups 2 and 3 stars (Y = 0.338 ± 0.014 ± 0.05); the error bar due to systematics is large, but a consistent analysis of data for several GCs confirms that stars in these groups within M 22 are probably overabundant in

The Little Ice Age was 1.0-1.5 °C cooler than current warm period according to LOD and NAO

NASA Astrophysics Data System (ADS)

Mazzarella, Adriano; Scafetta, Nicola

2018-02-01

We study the yearly values of the length of day (LOD, 1623-2016) and its link to the zonal index (ZI, 1873-2003), the Northern Atlantic oscillation index (NAO, 1659-2000) and the global sea surface temperature (SST, 1850-2016). LOD is herein assumed to be mostly the result of the overall circulations occurring within the ocean-atmospheric system. We find that LOD is negatively correlated with the global SST and with both the integral function of ZI and NAO, which are labeled as IZI and INAO. A first result is that LOD must be driven by a climatic change induced by an external (e.g. solar/astronomical) forcing since internal variability alone would have likely induced a positive correlation among the same variables because of the conservation of the Earth's angular momentum. A second result is that the high correlation among the variables implies that the LOD and INAO records can be adopted as global proxies to reconstruct past climate change. Tentative global SST reconstructions since the seventeenth century suggest that around 1700, that is during the coolest period of the Little Ice Age (LIA), SST could have been about 1.0-1.5 °C cooler than the 1950-1980 period. This estimated LIA cooling is greater than what some multiproxy global climate reconstructions suggested, but it is in good agreement with other more recent climate reconstructions including those based on borehole temperature data.

A Decadal-scale Air-sea Interaction Theory for North Atlantic Multidecadal Variability: the NAT-NAO-AMOC-AMO Coupled Mode and Its Remote Influences

NASA Astrophysics Data System (ADS)

Li, Jianping; Sun, Cheng; Jin, Fei-Fei

2017-04-01

ABSTRACT North Atlantic region shows prominent multidecadal variability. Observational analysis shows that the North Atlantic Oscillation (NAO) leads the oceanic Atlantic Multidecadal Oscillation (AMO) by 15-20 years and the latter also leads the former by around 15 years. The mechanisms are investigated using simulations from a fully coupled model, and a NATNAO-AMOC-AMO Coupled Mode is proposed to explain the multidecadal variability in North Atlantic region. The NAT-NAO-AMO-AMOC coupled mode has important remote influences on regional climates. Observational analysis identifies a significant in-phase relationship between the AMV and Siberian warm season (May to October) precipitation. The physical mechanism for this relationship is investigated using both observations and numerical simulations. North Atlantic sea surface temperature (SST) warming associated with the positive AMV phase can excite an eastward propagating wave train response across the entire Eurasian continent, which includes an east-west dipole structure over Siberia. The dipole then leads to anomalous southerly winds bringing moisture northward to Siberia; the precipitation increases correspondingly. Furthermore, a prominent teleconnection pattern of multidecadal variability of cold season (November to April) upper-level atmospheric circulation over North Africa and Eurasia (NA-EA) is revealed by empirical orthogonal function analysis of the Twentieth Century Reanalysis data, and this teleconnection pattern is referred to as the Africa-Asia multidecadal teleconnection pattern (AAMT). A strong inphase relationship is observed between the AAMT and Atlantic multidecadal variability (AMV) and this connection is mainly due to Rossby wave dynamics. The AAMT acts as an atmospheric bridge conveying the influence of AMV onto the downstream multidecadal climate variability.

Physical Biologycal Interactions Controlling Larvae Dispersion: Application to Regions in the Neighbourhood of the Estuaries of North Portugal

NASA Astrophysics Data System (ADS)

Almeida, Martinho Marta

Um modelo numerico tridimensional oceânico foi usado para estudar a influencia das condicoes fisicas na dispersao e recrutamento de larvas com migracao vertical diaria (MVD) activa na plataforma continental noroeste de Portugal. As primeiras simulacoes foram forcadas por mares e verificou-se que a interaccao entre MVD e correntes de mare nao e importante para o transporte de larvas na plataforma continental oeste portuguesa. O trabalho realizado com forcamento de mares incrementou o presente conhecimento da dinâmica da mare na regiao. A analise da variacao vertical dos parâmetros das elipses de mare mostra uma separacao clara entre os harmonicos diurnos e semi-diurnos, e entre a circulacao oceânica quase barotropica e as correntes com dependencia vertical na plataforma. Desprezando a interaccao entre MVD e as mares o proximo passo foi a construcao e validacao dum modelo realistico forcado por fluxos atmosfera-oceano, capaz de reproduzir as correntes dominantes, geradas pelo vento, na plataforma continental. Na configuracao criada a MVD das larvas foi simulada com quatro cenarios de distribuicao e migracao vertical. Foram feitas duas simulacoes, uma para o final do Inverno e outra para a Primavera, abrangendo os meses de Fevereiro a Abril e Abril a Junho de 2002. Estes periodos foram escolhidos pois exibem diferentes regimes de vento, nao favoravel e favoravel ao afloramento costeiro. Os resultados mostram que as particulas com MVD sofreram maior retencao na plataforma continental interna durante condicoes de afloramento do que em qualquer outra combinacao de cenario de migracao e regime de vento. Na costa noroeste da Peninsula Iberica, que nao exibe irregularidades topograficas que poderiam criar areas de concentracao e retencao, a MVD pode constituir um mecanismo importante para evitar a dispersao de larvas em direccao ao mar aberto. None

Cytofluorometric analysis of chondrotoxicity of fluoroquinolone antimicrobial agents.

PubMed

Hayem, G; Petit, P X; Levacher, M; Gaudin, C; Kahn, M F; Pocidalo, J J

1994-02-01

To better understand quinolone-related arthropathy, we conceived an experimental ex vivo model using cell cultures of articular chondrocytes issued from pretreated New Zealand White rabbits (NZW). Juvenile (4- to 5-week-old) NZW were orally dosed with ofloxacin or pefloxacin (300 mg/kg of body weight for 1 day) or with pefloxacin (300 mg/kg for 7 days). Adult (5-month-old) NZW were treated with pefloxacin (300 mg/kg for 1 day). Chondrocytes were enzymatically recovered from cartilage and were analyzed by cytofluorometry using 2',7'-dichlorofluorescein diacetate (DCFH-DA) and dihydrorhodamine 123 (DHR), reflecting cellular respiratory-burst activity, and rhodamine 123 (Rh123) and 10-N-nonyl-acridine orange (NAO), specific for the mitochondrial activity and mass, respectively. A significant increase in the respiratory burst was detected by DCFH-DA and DHR in all treated groups of young animals, compared with untreated control groups. No significant increase of respiratory burst was noted in older treated rabbits. The 7-day treatment resulted in a decrease in mitochondrial uptake of Rh123 and an increase in NAO uptake. Fluoroquinolone arthrotoxicity seems to involve in its early phase the respiratory burst of immature articular chondrocytes.

Biaxial seismic behaviour of reinforced concrete columns =

NASA Astrophysics Data System (ADS)

Rodrigues, Hugo Filipe Pinheiro

A analise dos efeitos dos sismos mostra que a investigacao em engenharia sismica deve dar especial atencao a avaliacao da vulnerabilidade das construcoes existentes, frequentemente desprovidas de adequada resistencia sismica tal como acontece em edificios de betao armado (BA) de muitas cidades em paises do sul da Europa, entre os quais Portugal. Sendo os pilares elementos estruturais fundamentais na resistencia sismica dos edificios, deve ser dada especial atencao a sua resposta sob acoes ciclicas. Acresce que o sismo e um tipo de acao cujos efeitos nos edificios exige a consideracao de duas componentes horizontais, o que tem exigencias mais severas nos pilares comparativamente a acao unidirecional. Assim, esta tese centra-se na avaliacao da resposta estrutural de pilares de betao armado sujeitos a acoes ciclicas horizontais biaxiais, em tres linhas principais. Em primeiro lugar desenvolveu-se uma campanha de ensaios para o estudo do comportamento ciclico uniaxial e biaxial de pilares de betao armado com esforco axial constante. Para tal foram construidas quatro series de pilares retangulares de betao armado (24 no total) com diferentes caracteristicas geometricas e quantidades de armadura longitudinal, tendo os pilares sido ensaiados para diferentes historias de carga. Os resultados experimentais obtidos sao analisados e discutidos dando particular atencao a evolucao do dano, a degradacao de rigidez e resistencia com o aumento das exigencias de deformacao, a energia dissipada, ao amortecimento viscoso equivalente; por fim e proposto um indice de dano para pilares solicitados biaxialmente. De seguida foram aplicadas diferentes estrategias de modelacao nao-linear para a representacao do comportamento biaxial dos pilares ensaiados, considerando nao-linearidade distribuida ao longo dos elementos ou concentrada nas extremidades dos mesmos. Os resultados obtidos com as varias estrategias de modelacao demonstraram representar adequadamente a resposta em termos das curvas

Effect of Tong Luo Jiu Nao on Aβ-degrading enzymes in AD rat brains.

PubMed

Liu, Yuan; Hua, Qian; Lei, Hongtao; Li, Pengtao

2011-09-02

Tong Luo Jiu Nao (TLJN) is a modern Chinese formula based on Traditional Chinese Medicine theory that has been used to treat ischemic cerebral stroke and vascular dementia. TLJN belongs to the ethnopharmacological family of medicines. In this study, we investigated the mechanism of the TLJN effect on Alzheimer's disease (AD). To investigate the effect of TLJN on β-amyloid-degrading enzymes and learning and memory in the AD rat brain. AD rats whose disease was induced by Aβ(25-35) injection into the bilateral hippocampus CA1 region were subjected to intragastric administration of various preparations. The experimental animals were healthy male Sprague-Dawley rats which were randomly divided into normal, sham, model, TLJN min, TLJN max and donepezil hydrochloride groups. Spontaneous alternation and passive avoidance behavior, which are regarded as measures of spatial learning and memory, were investigated using Y-maze testing. Western blotting and immunohistochemistry were used to observe the therapeutic effect of TLJN on the deposits of amyloid plaque and on the expression of synaptophysin, insulin-degrading enzyme and neprilysin. Y-maze results showed that the AD model group presented with spatial learning and memory impairments. Hematoxylin-eosin and Congo red staining indicated neuronal impairment and deposits of amyloid plaque in the model group and these results were consistent with their learning and memory deficits in the Y-maze. The TLJN-treated groups exhibited prolonged a cavity delitescence, decreased arm entries and improvement in learning and memory. Moreover, the structure of the neurons of the treated groups was restored and the expression of synaptophysin increased in both the hippocampus and cortex. In addition, their levels of insulin-degrading enzyme and neprilysin in the cortex and hippocampus were upregulated and the amyloid plaque was decreased. TLJN can improve learning and memory, up-regulate insulin-degrading enzyme and neprilysin levels

Mechanical behaviour of AlSiC nano composites produced by ball milling and spark plasma sintering =

NASA Astrophysics Data System (ADS)

Buchheim, Claudia Sofia de Andrade Redondo Murilhas

Neste trabalho foram produzidos nanocompositos de AlSiC misturando aluminio puro com nano particulas de SiC com diâmetro de 45 - 55 nm, usando, de forma sequencial, a tecnica da metalurgia do po e a compactacao por "Spark Plasma Sintering". O composito obtido apresentava graos com 100 nm de diâmetro, encontrandose as particulas de SiC localizadas, principalmente, nas fronteiras de grao. O nanocomposito sob a forma de provetes cilindricos foi submetido a testes de compressao uniaxial e a testes de nanoindentacao para analisar a influencia das nanoparticulas de SiC, da fracao volumica de acido estearico e do tempo de moagem, nas propriedades mecânicas do material. Para efeitos de comparacao, utilizouse o comportamento mecânico do Al puro processado em condicoes similares e da liga de aluminio AA1050O. A tensao limite de elasticidade do nanocomposito com 1% Vol./Vol. de SiC e dez vezes superior a do AA1050. O refinamento de grao a escala nano constitui o principal mecanismo de aumento de resistencia mecânica. Na realidade, o Al nanocristalino sem reforco de particulas de SiC, apresenta uma tensao limite de elasticidade sete vezes superior a da liga AA1050O. A adicao de 0,5 % Vol./Vol. e de 1 % Vol./Vol. de SiC conduzem, respetivamente, ao aumento da tensao limite de elasticidade em 47 % e 50%. O aumento do tempo de moagem e a adicao de acido estearico ao po durante a moagem conduzem apenas a um pequeno aumento da tensao de escoamento. A dureza do material medida atraves de testes de nanoindentacao confirmaram os dados anteriores. A estabilidade das microestruturas do aluminio puro e do nanocomposito AlSiC, foi testada atraves de recozimento de restauracao realizado as temperaturas de 150 °C e 250 °C durante 2 horas. Aparentemente, o tratamento termico nao influenciou as propriedades mecânicas dos materiais, excepto do nanocomposito com 1 % Vol./Vol. de SiC restaurado a temperatura de 250 °C, para o qual se observou uma reducao da tensao limite de elasticidade

Electrochemical Reduction of Oxygen in Aprotic Ionic Liquids Containing Metal Cations: A Case Study on the Na-O2 system.

PubMed

Azaceta, Eneko; Lutz, Lukas; Grimaud, Alexis; Vicent-Luna, Jose Manuel; Hamad, Said; Yate, Luis; Cabañero, German; Grande, Hans-Jurgen; Anta, Juan A; Tarascon, Jean-Marie; Tena-Zaera, Ramon

2017-04-10

Metal-air batteries are intensively studied because of their high theoretical energy-storage capability. However, the fundamental science of electrodes, electrolytes, and reaction products still needs to be better understood. In this work, the ionic liquid N-butyl-N-methylpyrrolidinium bis(trifluoromethanesulfonyl)imide (PYR14TFSI) was chosen to study the influence of a wide range of metal cations (M n+ ) on the electrochemical behavior of oxygen. The relevance of the theory of Lewis hard and soft acids and bases to predict satisfactorily the reduction potential of oxygen in electrolytes containing metal cations is demonstrated. Systems with soft and intermediate M n+ acidity are shown to facilitate oxygen reduction and metal oxide formation, whereas oxygen reduction is hampered by hard acid cations such as sodium and lithium. Furthermore, DFT calculations on the energy of formation of the resulting metal oxides rationalize the effect of M n+ on oxygen reduction. A case study on the Na-O 2 system is described in detail. Among other things, the Na + concentration of the electrolyte is shown to control the electrochemical pathway (solution precipitation vs. surface deposition) by which the discharge product grows. All in all, fundamental insights for the design of advanced electrolytes for metal-air batteries, and Na-air batteries in particular, are provided. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Influence of the North Atlantic Oscillation on European tropospheric composition: an observational and modelling study

NASA Astrophysics Data System (ADS)

Pope, R.; Chipperfield, M.

2017-12-01

The North Atlantic Oscillation (NAO) has a strong influence on winter-time North Atlantic and European circulation patterns. Under the positive phase of the NAO (NAO+), intensification of the climatological Icelandic low and Azores high pressure systems results in strong westerly flow across the Atlantic into Europe. Under the NAO negative phase (NAO-), there is a weakening of this meridional pressure gradient resulting in a southerly shift in the westerlies flow towards the sub-tropical Atlantic. Therefore, NAO+ and NAO- introduce unstable stormy and drier stable conditions into Europe, respectively. Under NAO+ conditions, the strong westerlies tend to enhance transport of European pollution (e.g. nitrogen oxides) away from anthropogenic source regions. While during NAO-, the more stable conditions lead to a build up of pollutants. However, secondary pollutants (i.e. tropospheric ozone) show the opposite signal where NAO+, while transporting primary pollutants away, introduces Atlantic ozone enriched air into Europe. Here ozone can form downwind of pollution from continental North America and be transported into Europe via the westerly flow. Under NAO-, this westerly ozone transport is reduced yielding lower European ozone concentrations also depleted further by ozone loss through the reaction with NOx, which has accumulated over the continent. Peroxyacetyl nitrate (PAN), observed in the upper troposphere - lower stratosphere (UTLS) by satellite, peaks over Iceland/Southern Greenland in NAO-, between 200-100 hPa, consistent with trapping by an anticyclone at this altitude. During NAO+, PAN is enhanced over the sub-tropical Atlantic and Arctic. Model simulations show that enhanced PAN over Iceland/Southern Greenland in NAO- is associated with vertical transport from the troposphere into the UTLS, while peak Arctic PAN in NAO+ is its accumulation given the strong northerly meridional transport in the UTLS. UTLS ozone spatial anomalies, relative to the winter

Novel materials based on chitosan, its derivatives and cellulose fibres

NASA Astrophysics Data System (ADS)

Fernandes, Susana Cristina de Matos

O presente trabalho tem como principal objectivo o desenvolvimento de novos materiais baseados em quitosano, seus derivados e celulose, na forma de nanofibras ou de papel. Em primeiro lugar procedeu-se a purificacao das amostras comerciais de quitosano e a sua caracterizacao exaustiva em termos morfologicos e fisicoquimicos. Devido a valores contraditorios encontrados na literatura relativamente a energia de superficie do quitosano, e tendo em conta a sua utilizacao como precursor de modificacoes quimicas e a sua aplicacao em misturas com outros materiais, realizou-se tambem um estudo sistematico da determinacao da energia de superficie do quitosano, da quitina e seus respectivos homologos monomericos, por medicao de ângulos de contacto Em todas as amostras comerciais destes polimeros identificaram-se impurezas nao polares que estao associadas a erros na determinacao da componente polar da energia de superficie. Apos a remocao destas impurezas, o valor da energia total de superficie (gs), e em particular da sua componente polar, aumentou consideravelmente. Depois de purificadas e caracterizadas, algumas das amostras de quitosano foram entao usadas na preparacao de filmes nanocompositos, nomeadamente dois quitosanos com diferentes graus de polimerizacao, correspondentes derivados soluveis em agua (cloreto de N-(3-(N,N,N-trimetilamonio)-2- hidroxipropilo) de quitosano) e nanofibras de celulose como reforco (celulose nanofibrilada (NFC) e celulose bacteriana (BC). Estes filmes transparentes foram preparados atraves de um processo simples e com conotacao 'verde' pela dispersao homogenea de diferentes teores de NFC (ate 60%) e BC (ate 40%) nas solucoes de quitosano (1.5% w/v) seguida da evaporacao do solvente. Os filmes obtidos foram depois caracterizados por diversas tecnicas, tais como SEM, AFM, difraccao de raio-X, TGA, DMA, ensaios de traccao e espectroscopia no visivel. Estes filmes sao altamente transparentes e apresentam melhores propriedades mecânicas e maior

Projection of North Atlantic Oscillation and its effect on tracer transport

NASA Astrophysics Data System (ADS)

Bacer, Sara; Christoudias, Theodoros; Pozzer, Andrea

2016-12-01

The North Atlantic Oscillation (NAO) plays an important role in the climate variability of the Northern Hemisphere, with significant consequences on long-range pollutant transport. We investigate the evolution of pollutant transport in the 21st century influenced by the NAO under a global climate change scenario. We use a free-running simulation performed by the ECHAM/MESSy Atmospheric Chemistry (EMAC) model coupled with the ocean general circulation model MPIOM, covering the period from 1950 until 2100. Similarly to other works, the model shows a future northeastward shift of the NAO centres of action and a weak positive trend of the NAO index (over 150 years). Moreover, we find that NAO trends (computed over periods shorter than 30 years) will continue to oscillate between positive and negative values in the future. To investigate the NAO effects on transport we consider carbon monoxide tracers with exponential decay and constant interannual emissions. We find that at the end of the century, the south-western Mediterranean and northern Africa will, during positive NAO phases, see higher pollutant concentrations with respect to the past, while a wider part of northern Europe will, during positive NAO phases, see lower pollutant concentrations. Such results are confirmed by the changes observed in the future for tracer concentration and vertically integrated tracer transport, differentiating the cases of "high NAO" and "low NAO" events.

North Atlantic Oscillation influence and weather types associated with winter total and extreme precipitation events in Spain

NASA Astrophysics Data System (ADS)

Queralt, S.; Hernández, E.; Barriopedro, D.; Gallego, D.; Ribera, P.; Casanova, C.

2009-12-01

An analysis of winter intensity and frequency of precipitation is presented, based on 102 daily precipitation stations over Spain and the Balearic Islands for the 1997-2006 decade. Precipitation stations have been merged in the eight different regions which compose the analyzed area by the use of an EOF analysis. NAO influence on the intensity and frequency of precipitation of each region is described in terms of mean precipitation, mean rain frequency, the number of extreme events, changes in the precipitation distribution and the prevalent synoptic configuration. Results indicate a non-stationary response; NAO signal being more evident in mid-late winter. Strong regional differences in the response to NAO are also found, which vary according to the specific character of the precipitation under analysis. Thus, NAO exerts a clear effect on the intensity of total and extreme precipitation rates in northern and westernmost Spanish regions, whereas the frequency of precipitation is clearly affected by NAO in central and southwestern areas. While the correlation between NAO and precipitation is negative for most of the analyzed area, two regions reveal positive responses to NAO in total precipitation occurrence and intensity for specific months. Further analyses reveal asymmetric responses to opposite phases of NAO in the precipitation distributions of some regions. The complex regional relationship between NAO and precipitation is also revealed through the modulation of the former in the preferred Circulation Weather Types associated to precipitation in each region. This spatially non-homogeneous NAO signal stresses the need of caution when employing Iberian precipitation as a proxy for NAO.

Atomic layer deposition of metal oxide by non-aqueous sol-gel chemistry =

NASA Astrophysics Data System (ADS)

Marichy, Catherine

O trabalho apresentado neste manuscrito foi desenvolvido no ambito do programa doutoral intitulado “Deposicao de Camadas Atomicas (ALD) de oxido de metais por sol-gel nao-aquoso”. O objectivo deste trabalho foi a preparacao de hetero-estruturas funcionais por ALD e a sua caracterizacao. Foi desenvolvido um novo processo de deposicao de oxido de estanho a temperatura baixa-moderada, utilizando um metodo ALD nao-aquoso, o qual foi aplicado com sucesso ao revestimento controlado das paredes internas e externas de nanotubos de carbono. Uma vez que a preparacao de nanomateriais funcionais requer uma elevada exatidao do processo de deposicao, foi demonstrada a deposicao precisa de filmes que se adaptem a forma do substrato ou de filmes nano-estruturados constituidos por particulas em varios substratos. Alem disso, foram depositados com grande exatidao varios oxidos de metal em nanotubos de carbono e demonstrou-se a possibilidade de ajustar o revestimento feito por ALD atraves do controlo da funcionalizacao da superficie do substrato nano-estruturado de carbono. As hetero-estruturas obtidas foram posteriormente aplicadas como sensores de gases. O melhoramento verificado na sensibilidade foi atribuido a formacao de heterojuncoes p-n entre o filme de oxido de metais e o suporte. O trabalho desenvolvido tendo como objetivo o controlo do revestimento por ALD atraves da funcionalizacao da superficie do suporte e certamente de interesse para o design de hetero-estruturas funcionais baseadas em substratos de carbono. De facto, durante o ultimo periodo do programa de doutoramento, este conceito foi alargado a funcionalizacao e revestimento com oxidos de metal de fibras de carbono preparadas por “electrospinning”, de forma a melhorar a estabilidade e a atividade eletrocatalitica de catalisadores a base de Pt. Este trabalho foi realizado maioritariamente na Universidade de Aveiro mas tambem na Universidade Nacional de Seul e beneficiou de varias colaboracoes internacionais

The Energy Cascade Associated with the North Atlantic Oscillation

NASA Astrophysics Data System (ADS)

Castanheira, J. M.; Marques, C. A. F.

2017-12-01

The North Atlantic Oscillation or Arctic Oscillation (NAO/AO), in a more hemispheric expression, is the dominant mode of variability of the extratropical atmospheric circulation. In the literature which analyses the association of low frequency variability of the NAO/AO with other climate variables, it is very common to find the idea of circulation and climate impacts of the NAO/AO. It is usually suggested that the NAO influences the position of North Atlantic storm tracks and the related transport of heat and moisture. However, in spite of the long time since the NAO variability mode was uncovered (Walker and Bliss, 1932), its underlying dynamical mechanisms are not well understood yet. In fact, it is not yet consensual that the NAO influences the position of the storm tracks, being possible that the relationship is in the opposite way with the storm track activity influencing de NAO. In this communication we will present an analysis of anomalies of the energy cascade associated with the NAO. A detailed version of the Lorenz energy cycle, which decomposes the energy flows into baroclinic and barotropic terms and into zonal mean and eddy components, was applied to the 6-hourly ERA-I reanalysis for the period of 1979 to 2016. The obtained results show that the positive NAO phase is preceded by an significant increase of synoptic baroclinic eddy activity. The eddy available potential energy is converted into kinetic energy and transferred to barotropic synoptic eddies. Then, the kinetic energy is transferred upscale into the barotropic planetary waves, which reproduce the NAO pattern. Therefore, we conclude that the synoptic baroclinic eddy activity forces the NAO variability. No clear signal was found for a modulating role of the NAO in the baroclinic eddy activity.

Revealing the Reaction Mechanism of Na–O 2 Batteries using Environmental Transmission Electron Microscopy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kwak, Won -Jin; Luo, Langli; Jung, Hun -Gi

Due to its high energy efficiency, sodium-oxygen (Na-O 2) batteries have been extensively studied recently. One of the critical challenges for the development of the Na-O 2 battery is the elucidation of the reaction mechanism, the reaction products, and thestructural and chemical evolution of reaction product as well as their correlation with the battery performance. Herein, in-situ TEM was employed to probe the reaction mechanism and the structural evolution of the discharge products in Na-O 2 batteries. The discharge product is featured by the formation of both cubic and conformal NaO 2. It has been noticed that the impingement ofmore » reaction product (NaO 2) can lead to the coarsening of the particle through coalescence. We also investigated the stability of the discharge product, noticing that the reaction product NaO 2 is stable in the case of solid electrolyte. Here, the present work provide unprecedented insight for the development of the Na-O 2 batteries.« less

Revealing the Reaction Mechanism of Na–O 2 Batteries using Environmental Transmission Electron Microscopy

DOE PAGES

Kwak, Won -Jin; Luo, Langli; Jung, Hun -Gi; ...

2018-01-15

Due to its high energy efficiency, sodium-oxygen (Na-O 2) batteries have been extensively studied recently. One of the critical challenges for the development of the Na-O 2 battery is the elucidation of the reaction mechanism, the reaction products, and thestructural and chemical evolution of reaction product as well as their correlation with the battery performance. Herein, in-situ TEM was employed to probe the reaction mechanism and the structural evolution of the discharge products in Na-O 2 batteries. The discharge product is featured by the formation of both cubic and conformal NaO 2. It has been noticed that the impingement ofmore » reaction product (NaO 2) can lead to the coarsening of the particle through coalescence. We also investigated the stability of the discharge product, noticing that the reaction product NaO 2 is stable in the case of solid electrolyte. Here, the present work provide unprecedented insight for the development of the Na-O 2 batteries.« less

The combined influence of the main European circulation patterns on carbon uptake by ecosystems

NASA Astrophysics Data System (ADS)

Bastos, Ana; Gouveia, Célia; Trigo, Ricardo

2014-05-01

of NAO has, as expected, the largest impact on European-wide carbon uptake patterns, the other modes appear to have a strong influence in particular regions, presenting overlapping effects with different signs which are due to differentiated responses to temperature and precipitation variability. We then rely on the historical experiment (CO2 concentration driven) of 12 ESMs from CMIP5 to assess the capability of those models to represent NAO, EA and SC patterns, the associated physical variables as well as the corresponding land carbon fluxes. Although all models simulate NAO reasonably well, and most represent EA and SC patterns satisfactorily, the response of the carbon cycle to these variability modes still needs further improvements. References [1] Bastos, A., Running, S. W., Gouveia, C.M., Trigo, R.M., (2013): J. Geophys. Res. Biogeosci.,118, 1247-1255, doi:10.1002/jgrg.20100. [2] Gouveia, C.M., Trigo, R. M., DaCamara, C. C., Libonati, R., Pereira, J. M. C. (2008): Int. J. Climatol., 28, 1835-1847, doi: 10.1002/joc.1682. [3] Trigo R.M., Valente M.A., Trigo I.F., Miranda P.M., Ramos A.M., Paredes D., García-Herrera R. (2008): Annals of the New York Academy of Sciences, 1146, 212-234, doi: 10.1196/annals.1446.014. [4] Comas-Bru, L., McDermott, F. (2013): Q.J.R. Meteorol. Soc., doi: 10.1002/qj.2158.

Variations in suicide method and in suicide occurrence by season and day of the week in Russia and the Nenets Autonomous Okrug, Northwestern Russia: a retrospective population-based mortality study.

PubMed

Sumarokov, Yury A; Brenn, Tormod; Kudryavtsev, Alexander V; Nilssen, Odd

2015-09-23

Suicide is an important world health issue, especially in territories inhabited by indigenous people. This investigated differences in suicide rates, suicide methods, and suicide occurrence by month and day of the week among the indigenous and non-indigenous populations of the Nenets Autonomous Okrug (NAO) and to compare the findings from the NAO with national Russian statistics. In this retrospective population-based mortality study we investigated all suicides that occurred in the NAO in 2002-2012 (N = 252). Suicide method and the month and day of the week suicide occurred was taken from autopsy reports and disaggregated by ethnic group (indigenous and non-indigenous) and sex. Data from the NAO were then compared with national data from the Russian Federal Statistics Service (Rosstat). Hanging was the most common suicide method in the NAO in both indigenous and non-indigenous populations. The proportion of suicides by hanging among males was lower in the NAO than in national data (69.3 vs 86.2 %), but the inverse was true for females (86.5 vs 74.9 %). Suicide by firearm and by cutting was significantly higher among the indigenous population in the NAO when compared with national data. Peaks in suicide occurrence were observed in May and September in the NAO, whereas national data showed only one peak in May. Suicide occurrence in the indigenous population of the NAO was highest in April, while the non-indigenous population showed peaks in May and September. Suicide occurrence in the NAO was highest on Fridays; in national data this occurrence was highest on Mondays. We showed different relative frequencies of suicide by hanging, cutting, and firearm, as well as different suicide occurrence by month and day of the week in the NAO compared with Russia as a whole. These results can be used to plan suicide prevention activities in the Russian Arctic.

76 FR 12627 - Airworthiness Directives; Diamond Aircraft Industries GmbH Models DA 42, DA 42 NG, and DA 42 M-NG...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-08

... Industries GmbH Models DA 42, DA 42 NG, and DA 42 M-NG Airplanes AGENCY: Federal Aviation Administration (FAA... on Diamond aeroplanes, the majority of which were DA 40. In additional, at least 18 doors have been... conditions) while the aeroplane was parked. All DA 40 and DA 42 aeroplanes have a system installed that...

Development of the Wintertime Sr/Ca-SST Record from Red Sea Corals as a Proxy for the North Atlantic Oscillation

NASA Astrophysics Data System (ADS)

Bernstein, W. N.; Hughen, K. A.

2009-12-01

The North Atlantic Oscillation (NAO) is one of the most pronounced and influential patterns in winter atmospheric circulation variability. This meridional redistribution of atmospheric mass across the Atlantic Ocean produces large changes in the intensity, number and direction of storms generated within the basin, and the regional climate of surrounding continents. The NAO exerts a significant impact on society, through influences on agriculture, fisheries, water management, energy generation and coastal development. NAO effects on climate extend from eastern North America across Europe to the eastern Mediterranean and Middle East. Changes in NAO behavior during the late 20th century have been linked to global warming; yet despite its importance, the causes and long-term patterns of NAO variability in the past remain poorly understood. In order to better predict the influence of the NAO on climate in the future, it is critical to examine multi-century NAO variability. The Red Sea is an excellent location from which to generate long NAO records for two reasons. First, patterns of wintertime sea surface temperature (SST) and salinity (SSS) in the Red Sea are highly correlated with NAO variability (Visbeck et al. 2001; Hurrell et al. 2003). Second, the tropical/subtropical Red Sea region contains fast growing long-lived massive Porites spp. corals with annually banded skeletons. These corals are ideal for generating well-dated high-resolution paleoclimatic records that extend well beyond the instrumental period. Here we present a study of winter SST and NAO variability in the Red sea region based on coral Sr/Ca data. In 2008, we collected multiple drill cores ranging in length from 1 to 4.1 meters from Porites corals at six sites spanning a large SST gradient. Sr/Ca measurements from multiple corals will be regressed against 23 years of satellite SST data, expanding the SST range over which we calibrate. A sampling resolution of 0.5mm will yield greater than bi

Autocorrelation descriptor improvements for QSAR: 2DA_Sign and 3DA_Sign

NASA Astrophysics Data System (ADS)

Sliwoski, Gregory; Mendenhall, Jeffrey; Meiler, Jens

2016-03-01

Quantitative structure-activity relationship (QSAR) is a branch of computer aided drug discovery that relates chemical structures to biological activity. Two well established and related QSAR descriptors are two- and three-dimensional autocorrelation (2DA and 3DA). These descriptors encode the relative position of atoms or atom properties by calculating the separation between atom pairs in terms of number of bonds (2DA) or Euclidean distance (3DA). The sums of all values computed for a given small molecule are collected in a histogram. Atom properties can be added with a coefficient that is the product of atom properties for each pair. This procedure can lead to information loss when signed atom properties are considered such as partial charge. For example, the product of two positive charges is indistinguishable from the product of two equivalent negative charges. In this paper, we present variations of 2DA and 3DA called 2DA_Sign and 3DA_Sign that avoid information loss by splitting unique sign pairs into individual histograms. We evaluate these variations with models trained on nine datasets spanning a range of drug target classes. Both 2DA_Sign and 3DA_Sign significantly increase model performance across all datasets when compared with traditional 2DA and 3DA. Lastly, we find that limiting 3DA_Sign to maximum atom pair distances of 6 Å instead of 12 Å further increases model performance, suggesting that conformational flexibility may hinder performance with longer 3DA descriptors. Consistent with this finding, limiting the number of bonds in 2DA_Sign from 11 to 5 fails to improve performance.

Use of Bacillus subtilis isolates from Tua-nao towards nutritional improvement of soya bean hull for monogastric feed application.

PubMed

Wongputtisin, P; Khanongnuch, C; Kongbuntad, W; Niamsup, P; Lumyong, S; Sarkar, P K

2014-09-01

Soya bean hull (SBH) is a cheap and high-fibre content feed ingredient that obtained after soya bean oil extraction. Microbial fermentation was expected to improve SBH qualities before applying to animals, especially monogastric animals. Two bacterial strains, Bacillus subtilis MR10 and TK8 that were isolated from Tua-nao, a traditional fermented soya bean in northern Thailand, were used for fermented soya bean hull (FSBH) production. Both could easily grow at 37°C in SBH as the sole substrate. MR10 produced the highest β-mannanase activity (400 U g(-1) SBH) on day 2, while TK8 produced the highest cellulase activity (14·5 U g(-1) SBH) on day 3. After fermentation, the nutritional quality of SBH was obviously improved by an increase in soluble sugars, soluble proteins, crude protein and crude lipid, and a decrease in the content of raffinose family oligosaccharides. Scavenging activity (%) of SBH against ABTS radical cation was also increased from 14 to 27 and 20% by MR10 and TK8 fermentation, respectively. According to the GRAS property of these both strains and various improvements of nutritional values, the fermented SBH proved to be a potential feed ingredient, especially for the monogastric animals. Normally, soya bean hull has been recognized as only a worthless by-product from soya bean oil production process because of its low utilizable nutrients. Our study introduced an alternative way to utilize this worthless residue using biotechnological knowledge. The nutritional quality of soya bean hull was improved by microbial fermentation. Fermented soya bean hull can be used as a cheap, safe and high-nutrient feed ingredient for livestock production, especially monogastric animals, to promote their growth performances, instead of using antibiotics in some regions of the world. © 2014 The Society for Applied Microbiology.

The influence of the winter North Atlantic Oscillation index on hospital admissions through diseases of the circulatory system in Lisbon, Portugal.

PubMed

Almendra, Ricardo; Santana, Paula; Vasconcelos, João; Silva, Giovani; Gonçalves, Fábio; Ambrizzi, Tércio

2017-02-01

The aim of this paper is to analyze the relationship between North Atlantic Oscillation (NAO), meteorological variables, air pollutants, and hospital admissions due to diseases of circulatory systems in Lisbon (Portugal) during winter months (2003-2012). This paper is one of the few studies analyzing the impact of NAO on health through its influence on thermal stress and air pollution and is the first to be conducted in Lisbon. This study uses meteorological data (synthetized into a thermal comfort index), air pollutant metrics, and the NAO index (all clustered in 10-day cycles to overcome daily variability of the NAO index). The relationship between morbidity, thermal comfort index, NAO index, and air pollutants was explored through several linear models adjusted to seasonality through a periodic function. The possible indirect effect between the NAO index and hospital admissions was tested, assuming that NAO (independent variable) is affecting hospital admissions (outcome variable) through thermal discomfort and/or pollution levels (tested as individual mediators). This test was conducted through causal mediation analysis and adjusted for seasonal variation. The results from this study suggest a possible indirect relationship between NAO index and hospital admissions. Although NAO is not significantly associated with hospital admissions, it is significantly associated with CO, PM 2.5 , NO, and SO 2 levels, which in turn increase the probability of hospitalization. The discomfort index (built with temperature and relative humidity) is significantly associated with hospital admissions, but its variability is not explained by the NAO index. This study highlights the impacts of the atmospheric circulation patterns on health. Furthermore, understanding the influence of the atmospheric circulation patterns can support the improvement of the existing contingency plans.

The role of the North Atlantic Oscillation in controlling U.K. butterfly population size and phenology

PubMed Central

Westgarth-Smith, Angus R; Roy, David B; Scholze, Martin; Tucker, Allan; Sumpter, John P

2012-01-01

1. The North Atlantic Oscillation (NAO) exerts considerable control on U.K. weather. This study investigates the impact of the NAO on butterfly abundance and phenology using 34 years of data from the U.K. Butterfly Monitoring Scheme (UKBMS). 2. The study uses a multi-species indicator to show that the NAO does not affect overall U.K. butterfly population size. However, the abundance of bivoltine butterfly species, which have longer flight seasons, were found to be more likely to respond positively to the NAO compared with univoltine species, which show little or a negative response. 3. A positive winter NAO index is associated with warmer weather and earlier flight dates for Anthocharis cardamines (Lepidoptera: Pieridae), Melanargia galathea (Lepidoptera: Nymphalidae), Aphantopus hyperantus (Lepidoptera: Nymphalidae), Pyronia tithonus (Lepidoptera: Nymphalidae), Lasiommata megera (Lepidoptera: Nymphalidae) and Polyommatus icarus (Lepidoptera: Lycaenidae). In bivoltine species, the NAO affects the phenology of the first generation, the timing of which indirectly controls the timing of the second generation. 4. The NAO influences the timing of U.K. butterfly flight seasons more strongly than it influences population size. PMID:22879687

Ionic Dependence of Reversal Voltage of the Light Response in Limulus Ventral Photoreceptors

PubMed Central

Brown, J. E.; Mote, M. I.

1974-01-01

The light-induced current as measured using a voltage clamp (holding voltage at resting potential) is attenuated when sodium ions in the bathing solution, Nao, are replaced by Tris, choline, or Li or when NaCl is replaced by sucrose. After replacement of NaCl by sucrose, the reversal voltage, V rev, for the light response becomes more negative. In this case, the slope of the V rev vs. log Nao near Nao = 425 mM is approximately 55 mV/decade increase of Nao (mean for 13 cells). The slope decreases at lower values of Nao. Choline is not impermeant and partially substitutes for Na; the slope of V rev vs. log Nao is 20 mV/decade (mean for three cells). V rev does not change when Na is replaced by Li. Decreases in the bath concentrations of Ca, Mg, Cl, or K do not affect V rev. When Nao = 212 mM, V rev becomes more positive when Ko is increased. Thus, light induces a change in membrane permeability to Na and probably also to K. PMID:4817353

Cod Collapse and the Climate in the North Atlantic

NASA Astrophysics Data System (ADS)

Meng, K. C.; Oremus, K. L.; Gaines, S.

2014-12-01

Effective fisheries management requires forecasting population changes. We find a negative relationship between the North Atlantic Oscillation (NAO) index and subsequently surveyed biomass and catch of Atlantic cod, Gadus morhua, off the New England coast. A 1-unit NAO increase is associated with a 17% decrease in surveyed biomass of age-1 cod the following year. This relationship persists as the cod mature, such that observed NAO can be used to forecast future adult biomass. We also document that an NAO event lowers catch for up to 15 years afterward. In contrast to forecasts by existing stock assessment models, our NAO-driven statistical model successfully hindcasts the recent collapse of New England cod fisheries following strong NAO events in 2007 and 2008 (see figure). This finding can serve as a template for forecasting other fisheries affected by climatic conditions.

The North Atlantic Oscillation Reconstructed at Bermuda for 220 Years Using Sr/Ca Ratios in Diploria labyrinthiformis (brain coral)

NASA Astrophysics Data System (ADS)

Goodkin, N. F.; Hughen, K. A.; Cohen, A. L.; Curry, W. B.; Doney, S. C.

2006-12-01

The North Atlantic Oscillation (NAO) is a meridional oscillation in atmospheric mass measured by pressure anomalies between Iceland (65°N, 23°W) and the Azores (38°N, 26°W) (Hurrell, 1995). Changes between the positive and negative phase of the NAO strongly influence weather patterns across the US, Europe and the Middle East. A shift in recent decades toward a sustained positive NAO has raised questions about the influence of greenhouse gas emissions on this system. Unfortunately, instrumental records are too short to identify the natural baseline variability of the NAO, and NAO reconstructions generally encompass only land-based proxies, excluding ocean processes. Winter-time sea surface temperatures (SST) in the Sargasso Sea have previously been shown to correlate to the NAO (Visbeck et al., 2001), and thus a long winter SST record based on proxy data could be used to reconstruct NAO variability back in time. Here we present an annually resolved winter-time strontium to calcium ratio (Sr/Ca) record from a 220-year old brain coral (Diploria labyrinthiformis) collected from the south shore of Bermuda. Brain coral is prevalent in Bermuda and shows distinct annual banding in its skeleton providing precise age models. Winter-time coral Sr/Ca has previously been shown to accurately record winter SST free from growth rate influences (Goodkin et al., 2005), and that relationship is confirmed here. Cross-spectral analysis between winter-time coral Sr/Ca and four instrumental and proxy records of the NAO (Hurrell, 1995, Jones et al., 1997, Luterbacher et al., 2001, Cook et al., 2002) show two frequencies of coherence with >95% confidence. At periods greater than 20 years and between 3 and 5 years, the coral Sr/Ca effectively captures the NAO variability. Filtering the coral record to these frequencies and comparing to the instrumental and proxy records, including another marine-based NAO reconstruction from the North and Norwegian Seas (Schoene et al., 2003), show

The Global Warming Hiatus Tied to the North Atlantic Oscillation and Its Prediction

NASA Astrophysics Data System (ADS)

Li, J.; Sun, C.

2015-12-01

The twentieth century Northern Hemisphere mean surface temperature (NHT) is characterized by a multidecadal warming-cooling-warming pattern followed by a flat trend since about 2000 (recent warming hiatus). Here we demonstrate that the multidcadal variability in NHT including the recent warming hiatus is tied to the North Atlantic Oscillation (NAO) and the NAO is implicated as a useful predictor of NHT multidecadal variability. Observational analysis shows that the NAO leads both the detrended NHT and oceanic Atlantic Multidecadal Oscillation (AMO) by 15-20 years. Theoretical analysis illuminates that the NAO precedes NHT multidecadal variability through its delayed effect on the AMO due to the large thermal inertia associated with slow oceanic processes. The CCSM4 model is employed to investigate possible physical mechanisms. The positive NAO forces the strengthening of the Atlantic meridional overturning circulation (AMOC) and induces a basin-wide uniform sea surface temperature (SST) warming that corresponds to the AMO. The SST field exhibits a delayed response to the preceding enhanced AMOC, and shows a pattern similar to the North Atlantic tripole (NAT), with SST warming in the northern North Atlantic and cooling in the southern part. This SST pattern (negative NAT phase) may lead to an atmospheric response that resembles the negative NAO phase, and subsequently the oscillation proceeds, but in the opposite sense. Based on these mechanisms, a simple delayed oscillator model is established to explain the quasi-periodic multidecadal variability of the NAO. The magnitude of the NAO forcing of the AMOC/AMO and the time delay of the AMOC/AMO feedback are two key parameters of the delayed oscillator. For a given set of parameters, the quasi 60-year cycle of the NAO can be well predicted. This delayed oscillator model is useful for understanding of the oscillatory mechanism of the NAO, which has potential for decadal predictions as well as the interpretation of proxy

Origin of the DA and non-DA white dwarf stars

NASA Technical Reports Server (NTRS)

Shipman, Harry L.

1989-01-01

Various proposals for the bifurcation of the white dwarf cooling sequence are reviewed. 'Primordial' theories, in which the basic bifurcation of the white dwarf sequence is rooted in events predating the white dwarf stage of stellar evolution, are discussed, along with the competing 'mixing' theories in which processes occurring during the white dwarf stage are responsible for the existence of DA or non-DA stars. A new proposal is suggested, representing a two-channel scenario. In the DA channel, some process reduces the hydrogen layer mass to the value of less than 10 to the -7th. The non-DA channel is similar to that in the primordial scenario. These considerations suggest that some mechanism operates in both channels to reduce the thickness of the outermost layer of the white dwarf. It is also noted that accretion from the interstellar medium has little to do with whether a particular white dwarf becomes a DA or a non-DA star.

Role of the North Atlantic Oscillation in decadal temperature trends

NASA Astrophysics Data System (ADS)

Iles, Carley; Hegerl, Gabriele

2017-11-01

Global temperatures have undergone periods of enhanced warming and pauses over the last century, with greater variations at local scales due to internal variability of the climate system. Here we investigate the role of the North Atlantic Oscillation (NAO) in decadal temperature trends in the Northern Hemisphere for periods with large decadal NAO trends. Using a regression based technique we find a best estimate that trends in the NAO more than halved (reduced by 57%, 5%-95%: 47%-63%) the winter warming over the Northern Hemisphere extratropics (NH; 30N-90N) from 1920-1971 and account for 45% (±14%) of the warming there from 1963-1995, with larger impacts on regional scales. Over the period leading into the so-called warming hiatus, 1989-2013, the NAO reduced NH winter warming to around one quarter (24%; 19%-31%) of what it would have been, and caused large negative regional trends, for example, in Northern Eurasia. Warming is more spatially uniform across the Northern Hemisphere after removing the NAO influence in winter, and agreement with multi-model mean simulated trends improves. The impact of the summer NAO is much weaker, but still discernible over Europe, North America and Greenland, with the downward trend in the summer NAO from 1988-2012 reducing warming by about a third in Northern Europe and a half in North America. A composite analysis using CMIP5 control runs suggests that the ocean response to prolonged NAO trends may increase the influence of decadal NAO trends compared to estimates based on interannual regressions, particularly in the Arctic. Results imply that the long-term NAO trends over the 20th century alternately masked or enhanced anthropogenic warming, and will continue to temporarily offset or enhance its effects in the future.

A 3000-year annual-resolution record of the North Atlantic Oscillation

NASA Astrophysics Data System (ADS)

Kelly, B. F.; Mariethoz, G.; Hellstrom, J.; Baker, A.

2013-12-01

The North Atlantic Oscillation provides an index of North Atlantic climate variability. The 947-yr long annual resolution record of the North Atlantic Oscillation (NAO) of Trouet et al. (2009, Science, 324, 78-81), the NAO Morocco-Scotland index, combined tree ring and stalagmite data, the latter a single stalagmite growth rate archive from NW Scotland. Trouet et al (2009) noted the unusual persistence of the positive phase of the NAO during the Medieval Climate Anomaly (MCA; 1050-1400AD). In order to better assess the uniqueness of the persistently positive NAO in the MCA, we extend the speleothem portion of the proxy NAO record with a composite of five stalagmites from the same cave system. We present the first-ever composite speleothem growth rate record. Using a combination of lamina counting, U-Th dating, and correlation between growth rate series, we build a continuous, annual-resolution, annually laminated, stalagmite growth rates series for the last 3000 years. We use geostatistical and stochastic approaches appropriate to stalagmite growth rate time series to characterise uncertainty in the stalagmite series and to screen them for periods of relative climate sensitivity vs. periods where there is hydrologically introduced, non-climatic variability. We produce the longest annual-resolution annual lamina record of the NAO for the last 3000 years. The screened stalagmite series is compared to instrumental and proxy records of the NAO. Spectral and wavelet analysis demonstrates that the series contains significant decadal to centennial scale periodicity throughout the record. We demonstrate that the persistently positive NAO during the MCA (1080-1460 CE) is remarkable within the last 3000 years. Two other phases of persistent, positive NAO, occur at 290-550 CE and 660-530 BCE, in agreement with the lower resolution, 5,200-yr Greenland lake sediment NAO proxy (Olsen et al, 2012, Nature Geoscience, 5, 808-812).

Winter North Atlantic Oscillation impact on European precipitation and drought under climate change

NASA Astrophysics Data System (ADS)

Tsanis, I.; Tapoglou, E.

2018-01-01

The North Atlantic Oscillation (NAO) is responsible for the climatic variability in the Northern Hemisphere, in particular, in Europe and is related to extreme events, such as droughts. The purpose of this paper is to study the correlation between precipitation and winter (December-January-February-March (DJFM)) NAO both for the historical period (1951-2000) and two future periods (2001-2050 and 2051-2100). NAO is calculated for these three periods by using sea level pressure, while precipitation data from seven climate models following the representative concentration pathway (RCP) 8.5 are also used in this study. An increasing trend in years with positive DJFM NAO values in the future is defined by this data, along with higher average DJFM NAO values. The correlation between precipitation and DJFM NAO is high, especially in the Northern (high positive) and Southern Europe (high negative). Therefore, higher precipitation in Northern Europe and lower precipitation in Southern Europe are expected in the future. Cross-spectral analysis between precipitation and DJFM NAO time series in three different locations in Europe revealed the best coherence in a dominant cycle between 3 and 4 years. Finally, the maximum drought period in terms of consecutive months with drought is examined in these three locations. The results can be used for strategic planning in a sustainable water resources management plan, since there is a link between drought events and NAO.

The major histocompatibility complex genes impact pain response in DA and DA.1U rats.

PubMed

Guo, Yuan; Yao, Fan-Rong; Cao, Dong-Yuan; Li, Li; Wang, Hui-Sheng; Xie, Wen; Zhao, Yan

2015-08-01

Our recent studies have shown that the difference in basal pain sensitivity to mechanical and thermal stimulation between Dark-Agouti (DA) rats and a novel congenic DA.1U rats is major histocompatibility complex (MHC) genes dependent. In the present study, we further used DA and DA.1U rats to investigate the role of MHC genes in formalin-induced pain model by behavioral, electrophysiological and immunohistochemical methods. Behavioral results showed biphasic nociceptive behaviors increased significantly following the intraplantar injection of formalin in the hindpaw of DA and DA.1U rats. The main nociceptive behaviors were lifting and licking, especially in DA rats (P<0.001 and P<0.01). The composite pain scores (CPS) in DA rats were significantly higher than those in DA.1U rats in both phases of the formalin test (P<0.01). Electrophysiological results also showed the biphasic increase in discharge rates of C and Aδ fibers of L5 dorsal root in the two strains, and the net change of the discharge rate of DA rats was significantly higher than that of DA.1U rats (P<0.05). The mechanical thresholds decreased after formalin injection in both strains (P<0.01), and the net change in the mechanical threshold in DA was greater than that in DA.1U rats (P<0.05). The expression of RT1-B, representation of MHC class II molecule, in laminae I-II of L4/5 spinal cord in DA rats was significantly higher than that in DA.1U rats in the respective experimental group (P<0.05). These results suggested that both DA and DA.1U rats exhibited nociceptive responses in formalin-induced pain model and DA rats were more sensitive to noxious chemical stimulus than DA.1U rats, indicating that MHC genes might contribute to the difference in pain sensitivity. Copyright © 2015 Elsevier Inc. All rights reserved.

New England Cod Collapse and the Climate.

PubMed

Meng, Kyle C; Oremus, Kimberly L; Gaines, Steven D

2016-01-01

To improve fishery management, there is an increasing need to understand the long-term consequences of natural and anthropogenic climate variability for ecological systems. New England's iconic cod populations have been in decline for several decades and have recently reached unprecedented lows. We find that 17% of the overall decline in Gulf of Maine cod biomass since 1980 can be attributed to positive phases of the North Atlantic Oscillation (NAO). This is a consequence of three results: i) a 1-unit increase in the NAO winter index is associated with a 17% decrease in the spring biomass of age-1 cod the following year; ii) this NAO-driven decrease persists as the affected cohort matures; iii) fishing practices appear to exacerbate NAO's direct biological effect such that, since 1913, a 1-unit increase in the NAO index lowers subsequent cod catch for up to 19 years. The Georges Bank cod stock displays similar patterns. Because we statistically detect a delay between the NAO and subsequent declines in adult biomass, our findings imply that observed current NAO conditions can be used in stock forecasts, providing lead time for adaptive policy. More broadly, our approach can inform forecasting efforts for other fish populations strongly affected by natural and anthropogenic climatic variation.

North Atlantic Oscillation influence on the stramflows of the Iberian Rivers

NASA Astrophysics Data System (ADS)

Lorenzo-Lacruz, J.; González-Hidalgo, J. C.; Vicente-Serrano, S. M.; López-Moreno, J. I.

2010-09-01

"NORTH ATLANTIC OSCILLATION INFLUENCE ON THE STREAMFLOWS OF THE IBERIAN RIVERS" LORENZO-LACRUZ, J. ¹, GONZÁLEZ-HIDALGO, J.C.², VICENTE-SERRANO, S.M. ¹, LÓPEZ-MORENO, J.I.¹ ¹Instituto Pirenaico de Ecología, CSIC (Spanish Research Council), Campus de Aula Dei, P.O. Box 202, Zaragoza 50080, Spain ²Departamento de Geografía, Universidad de Zaragoza, Zaragoza, Spain. We analyzed the North Atlantic Oscillation (NAO) influence on the monthly river discharges of Iberian rivers from 1945 to 2005. The study covers most of the Iberian river basins, using 187 monthly discharge series. The aim of this study is to determine the role of the variability of the NAO on the Iberian river discharges. Using the winter NAO we calculated correlations with the monthly river discharge series. We identified the positive and negative phases of the winter NAO for the period 1945-2006, and related to river discharge anomalies. Significant differences in river discharge were found between the positive and negative NAO phases with negative anomalies (dry conditions) during positive NAO periods, and positive anomalies (wet conditions) during negative NAO periods The results show a consistent and strong control of the river discharges by the winter NAO, but some spatial differences are shown, as three different domains were defined: a region under the direct influence of the NAO (central and western part of the Iberian Peninsula), a transition zone (Ebro Valley) and region free from that influence (Eastern part of the Iberian Peninsula). The spatial differences are also identified in the annual pattern of discharge anomalies. The basin characteristics, the location of the gauging stations and the human management are the possible drivers of these differences.

Observed linkages between the northern annular mode/North Atlantic Oscillation, cloud incidence, and cloud radiative forcing

NASA Astrophysics Data System (ADS)

Li, Ying; Thompson, David W. J.; Huang, Yi; Zhang, Minghong

2014-03-01

The signature of the northern annular mode/North Atlantic Oscillation (NAM/NAO) in the vertical and horizontal distribution of tropospheric cloudiness is investigated in CloudSat and CALIPSO data from June 2006 to April 2011. During the Northern Hemisphere winter, the positive polarity of the NAM/NAO is marked by increases in zonally averaged cloud incidence north of ~60°N, decreases between ~25 and 50°N, and increases in the subtropics. The tripolar-like anomalies in cloud incidence associated with the NAM/NAO are largest over the North Atlantic Ocean basin/Middle East and are physically consistent with the NAM/NAO-related anomalies in vertical motion. Importantly, the NAM/NAO-related anomalies in tropospheric cloud incidence lead to significant top of atmosphere cloud radiative forcing anomalies that are comparable in amplitude to those associated with the NAM/NAO-related temperature anomalies. The results provide observational evidence that the most prominent pattern of Northern Hemisphere climate variability is significantly linked to variations in cloud radiative forcing. Implications for two-way feedback between extratropical dynamics and cloud radiative forcing are discussed.

Pre-Schoolers' Interest and Caring Behaviour around a Humanoid Robot

ERIC Educational Resources Information Center

Ioannou, Andri; Andreou, Emily; Christofi, Maria

2015-01-01

This exploratory case study involved a humanoid robot, NAO, and four pre-schoolers. NAO was placed in an indoor playground together with other toys and appeared as a peer who played, talked, danced and said stories. Analysis of video recordings focused on children's behaviour around NAO and how the robot gained children's attention and…

Alcohol and suicide in the Nenets Autonomous Okrug and Arkhangelsk Oblast, Russia

PubMed Central

Sumarokov, Yury A.; Brenn, Tormod; Kudryavtsev, Alexander V.; Sidorenkov, Oleg; Nilssen, Odd

2016-01-01

Background High suicide rates in the Russian North are coupled with high alcohol consumption in the described populations. Objective To investigate the potential role of alcohol consumption on suicides in the Nenets Autonomous Okrug (NAO) in 2002–2012 and to compare this information with corresponding data from the neighboring Arkhangelsk Oblast (AO). Design Retrospective population-based mortality study. Methods Data from autopsy reports were used to identify 252 cases of suicide in the NAO and 1,198 cases in the AO in the period 2002–2012. Postmortem blood alcohol content (BAC) was available for 228 cases in the NAO and 1,185 cases in the AO. BAC as well as other selected variables were compared between the NAO and the AO among women and men, different age groups, ethnic groups, and selected variables of suicide. Results Alcohol was present in the blood of 74.1% of male and 82.9% of female suicide cases in the NAO, which was significantly higher than the proportions found in the AO (59.3% of male and 46.6% female cases). BAC<1.0‰ and between 2.0 and 3.0‰ were more frequently found among suicide cases in the NAO than those in the AO. Conclusions Our findings specify that alcohol drinking may be an essential risk factor for suicide in the NAO, and that this factor may be of greater importance in the indigenous population of the NAO than among Russians in the AO. PMID:27452190

3D coordination polymers with nitrilotriacetic and 4,4'-bipyridyl mixed ligands: structural variation based on dinuclear or tetranuclear subunits assisted by Na-O and/or O-H...O interactions.

PubMed

Lü, Xing-Qiang; Jiang, Ji-Jun; Chen, Chun-Long; Kang, Bei-Sheng; Su, Cheng-Yong

2005-06-27

The reactions of Cu(II) with the mixed nitrilotriacetic acid (H3NTA) and 4,4'-bipyridyl (4,4'-bpy) ligands in different metal-to-ligand ratios in the presence of NaOH and NaClO4 afforded two complexes, Na3[Cu2(NTA)2(4,4'-bpy)]ClO4 x 5H2O (1) and [Cu2(NTA) (4,4'-bpy)2]ClO4 x 4H2O (2). The two complexes have been characterized by elemental analysis, IR, XRD, and single-crystal X-ray diffraction. 1 contains a basic doubly negatively charged [Cu2(NTA)2(4,4'-bpy)]2- dinuclear unit which was further assembled via multiple Na-O and O-H...O interactions into a three-dimensional (3D) pillared-layer structure. 2 features a two-dimensional (2D) undulated brick-wall architecture containing a basic doubly positively charged [Cu4(NTA)2(4,4'-bpy)2]2+ tetranuclear unit. The 2D network possesses large cavities hosting guest molecules and was further assembled via O-H...O hydrogen bonds into a 3D structure with several channels running in different directions.

Chemical profiling and quantification of Dan-Deng-Tong-Nao-capsule using ultra high performance liquid chromatography coupled with high resolution hybrid quadruple-orbitrap mass spectrometry.

PubMed

Lv, Xiao-Jing; Sun, Zhi; Wang, Pei-Le; Yang, Jing; Xu, Tan-Ye; Jia, Qing-Quan; Li, Da-Wei; Su, Fang-Yi; Zhu, Zhen-Feng; Kang, Jian; Zhang, Xiao-Jian

2018-01-30

Dan-Deng-Tong-Nao capsule (DDTN) was a traditional Chinese medicine (TCM) formula, and has been widely used for the treatment of stroke clinically which caused by blood stasis. However, the bioactive substances and mechanism are unclear because of the complex compositions in DDTN. In this research, An ultra high-performance liquid chromatography (UHPLC) coupled with hybrid quadruple-orbitrap mass spectrometry (Q-Orbitrap MS) method was utilized to identify the chemical constituents of DDTN. In total, 102 compounds including diterpenes, lactones, flavonoids, and phenolic acids were identified by the accurate masses and fragmentation pathways, and 18 of them were unambiguously determined by comparison of reference standards. Besides, 12 representative compounds were simultaneously quantification analyzed and successfully applified for detecting in 9 batches of DDTN samples by UHPLC-Q-Orbitrap MS in parallel reaction monitoring (PRM) mode. The proposed approach was validated to be satisfied in terms of linearity (0.9954-0.9999), LOD (0.771ng/mL), LOQ (2.568ng/mL), intra-day precision ( <2.68%), inter-day precision ( <4.52%), repeatability ( <2.96%), stability ( <3.21%), and recovery (94.6-105.5%). The results indicate that the method of combining UHPLC with Q-Orbitrap MS is practical and efficient for the chemical clarification in DDTN, and has great potential for the integrating quality control of other traditional Chinese medicines. Copyright © 2017 Elsevier B.V. All rights reserved.

Regional Famine Patterns of The Last Millennium as Influenced by Aggregated Climate Teleconnections

NASA Astrophysics Data System (ADS)

Santoro, Michael Melton

Famine is the result of a complex set of environmental and social factors. Climate conditions are established as environmental factors contributing to famine occurrence, often through teleconnective patterns. This dissertation is designed to investigate the combined influence on world famine patterns of teleconnections, specifically the North Atlantic Oscillation (NAO), Southern Oscillation (SO), Pacific Decadal Oscillation (PDO), Atlantic Multidecadal Oscillation (AMO), or regional climate variations such as the South Asian Summer Monsoon (SASM). The investigation is three regional case studies of famine patterns specifically, Egypt, the British Isles, and India. The first study (published in Holocene) employs the results of a Principal Component Analysis (PCA) yielding a SO-NAO eigenvector to predict major Egyptian famines between AD 1049-1921. The SO-NAO eigenvector (1) successfully discriminates between the 5-10 years preceding a famine and the other years, (2) predicts eight of ten major famines, and (3) correctly identifies fifty out of eighty events (63%) of food availability decline leading up to major famines. The second study investigates the impact of the NAO, PDO, SO, and AMO on 63 British Isle famines between AD 1049 and 1914 attributed to climate causes in historical texts. Stepwise Regression Analysis demonstrates that the 5-year lagged NAO is the primary teleconnective influence on famine patterns; it successfully discriminates 73.8% of weather-related famines in the British Isles from 1049 to 1914. The final study identifies the aggregated influence of the NAO, SO, PDO, and SASM on 70 Indian famines from AD 1049 to 1955. PCA results in a NAO-SOI vector and SASM vector that predicts famine conditions with a positive NAO and negative SO, distinct from the secondary SASM influence. The NAO-famine relationship is consistently the strongest; 181 of 220 (82%) of all famines occurred during positive NAO years. Ultimately, the causes of famine are complex

The influence of sea surface temperature anomalies on low-frequency variability of the North Atlantic Oscillation

NASA Astrophysics Data System (ADS)

Manganello, Julia V.

2008-05-01

The influence of sea surface temperature anomalies (SSTA) on multi-year persistence of the North Atlantic Oscillation (NAO) during the second half of the twentieth century is investigated using the Center for Ocean-Land-Atmosphere Studies (COLA) Atmospheric GCM (AGCM) with an emphasis on isolating the geographic location of the SSTA that produce this influence. The present study focuses on calculating the atmospheric response to the SSTA averaged over 1988 1995 (1961 1968) corresponding to the observed period of strong persistence of the positive (negative) phase of the decadal NAO. The model response to the global 1988 1995 average SSTA shows a statistically significant large-scale pattern characteristic of the positive phase of the NAO. Forcing with the global 1961 1968 average SSTA generates a NAO of the opposite polarity compared to observations. However, all large-scale features both in the model and observations during this period are weaker in magnitude and less significant compared to 1988 1995. Additional idealized experiments show that over the northern center of the NAO the non-linear component of the forced response appears to be quite important and acts to enhance the positive NAO signal. On the other hand, over the southern center where the model response is the strongest, it is also essentially linear. The 1988 1995 average SSTA restricted to the western tropical Pacific region produce a positive NAO remarkably similar in structure but stronger in magnitude than the model response to the global and tropical Indo-Pacific 1988 1995 forcing. A 200-hPa geopotential height response in these experiments shows a positive anomaly over the southern center of the NAO embedded in the Rossby wave trains propagating from the western tropical Pacific. Indian Ocean SSTA lead to much weaker positive NAO primarily through the effect on its northern center. SST forcing confined to the North Atlantic north of equator does not produce a response statistically different

Benchmark of Ab Initio Bethe-Salpeter Equation Approach with Numeric Atom-Centered Orbitals

NASA Astrophysics Data System (ADS)

Liu, Chi; Kloppenburg, Jan; Kanai, Yosuke; Blum, Volker

The Bethe-Salpeter equation (BSE) approach based on the GW approximation has been shown to be successful for optical spectra prediction of solids and recently also for small molecules. We here present an all-electron implementation of the BSE using numeric atom-centered orbital (NAO) basis sets. In this work, we present benchmark of BSE implemented in FHI-aims for low-lying excitation energies for a set of small organic molecules, the well-known Thiel's set. The difference between our implementation (using an analytic continuation of the GW self-energy on the real axis) and the results generated by a fully frequency dependent GW treatment on the real axis is on the order of 0.07 eV for the benchmark molecular set. We study the convergence behavior to the complete basis set limit for excitation spectra, using a group of valence correlation consistent NAO basis sets (NAO-VCC-nZ), as well as for standard NAO basis sets for ground state DFT with extended augmentation functions (NAO+aug). The BSE results and convergence behavior are compared to linear-response time-dependent DFT, where excellent numerical convergence is shown for NAO+aug basis sets.

Persistent positive North Atlantic oscillation mode dominated the Medieval Climate Anomaly.

PubMed

Trouet, Valérie; Esper, Jan; Graham, Nicholas E; Baker, Andy; Scourse, James D; Frank, David C

2009-04-03

The Medieval Climate Anomaly (MCA) was the most recent pre-industrial era warm interval of European climate, yet its driving mechanisms remain uncertain. We present here a 947-year-long multidecadal North Atlantic Oscillation (NAO) reconstruction and find a persistent positive NAO during the MCA. Supplementary reconstructions based on climate model results and proxy data indicate a clear shift to weaker NAO conditions into the Little Ice Age (LIA). Globally distributed proxy data suggest that this NAO shift is one aspect of a global MCA-LIA climate transition that probably was coupled to prevailing La Niña-like conditions amplified by an intensified Atlantic meridional overturning circulation during the MCA.

Intraseasonal Characteristics Of North Atlantic Oscillation

NASA Astrophysics Data System (ADS)

Bojariu, R.; Gimeno, L..; de La Torre, L.; Nieto, R.

There is evidence of a temporal structure of regional response to the NAO variability in the cold season (e.g. NAO-related climate fluctuations reveal their strongest signal in January). To document the details of NAO intraseasonal characteristics we anal- ysed surface and upper air variables (air surface temperature, sea-ice concentration, sea surface temperature, and sea level pressure and geopotential heights at 700 hPa level) in individual months, from November to April. The data consist of 40 years of monthly reanalyses (1961-2000) extracted from the NCAR-NCEP data set. In ad- dition, snow cover data are used (monthly snow cover frequencies from the Climate Prediction Centre and number of days with snow cover from the Former Soviet Union Hydrological Snow Surveys available at the National Snow and Ice Data Centre). A NAO-related signal with predictive potential has been identified in November air surface temperature over Europe and SLP and geopotential heights over Eurasia. Neg- ative thermal anomalies over the Central Europe and positive geopotential anomalies at 700 hPa over a latitudinal belt from Arabic Peninsula to Pacific Ocean are associated with a high NAO index in the following winter. The November thermal anomalies that seem to be related to the NAO interannual persistence are also linked with the fluctu- ations of snow cover over Europe. Both tropical and high latitude influences may play a role in the onset of the November signal and in further NAO development.

Sodium-Oxygen Batteries: A Comparative Review from Chemical and Electrochemical Fundamentals to Future Perspective.

PubMed

Yadegari, Hossein; Sun, Qian; Sun, Xueliang

2016-09-01

Alkali metal-oxygen (Li-O2 , Na-O2 ) batteries have attracted a great deal of attention recently due to their high theoretical energy densities, comparable to gasoline, making them attractive candidates for application in electrical vehicles. However, the limited cycling life and low energy efficiency (high charging overpotential) of these cells hinder their commercialization. The Li-O2 battery system has been extensively studied in this regard during the past decade. Compared to the numerous reports of Li-O2 batteries, the research on Na-O2 batteries is still in its infancy. Although, Na-O2 batteries show a number of attractive properties such as low charging overpotential and high round-trip energy efficiency, their cycling life is currently limited to a few tens of cycles. Therefore, understanding the chemistry behind Na-O2 cells is critical towards enhancing their performance and advancing their development. Chemical and electrochemical reactions of Na-O2 batteries are reviewed and compared with those of Li-O2 batteries in the present review, as well as recent works on the chemical composition and morphology of the discharge products in these batteries. Furthermore, the determining kinetics factors for controlling the chemical composition of the discharge products in Na-O2 cells are discussed and the potential research directions toward improving Na-O2 cells are proposed. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Decadal variability in the Northern Hemisphere winter circulation: Role of internal and external drivers

NASA Astrophysics Data System (ADS)

Maliniemi, V.; Asikainen, T.; Mursula, K.

2017-12-01

Northern Hemisphere winter circulation is known to be affected by both internal and external (solar-related) forcings. Earlier studies have shown ENSO and volcanic activity to produce negative and positive North Atlantic Oscillation (NAO) type responses, respectively. In addition, recent studies have shown a positive NAO response related to both geomagnetic activity (proxy for solar wind driven particle precipitation) and sunspot activity (proxy for solar irradiance). These solar-related signals have been suggested to be due to the changes in the polar vortex. Here the relative role of these four internal and external drivers on wintertime circulation in the Northern Hemisphere is studied. The phase of the quasi-biennial oscillation (QBO) is used to study the driver responses for different stratospheric conditions. Moreover, the effects are separated for early (Dec/Jan) and late (Feb/Mar) winter. The global pattern of ENSO is very similar (negative NAO) otherwise, but in early winter and westerly QBO the pattern is changed in the Atlantic sector to a weakly positive NAO. The positive NAO pattern due to volcanic activity is more pronounced for westerly QBO in both early and late winter. The positive NAO pattern produced by geomagnetic activity is obtained during easterly QBO phase in both early and late winter. Sunspot related NAO response in late winter is also strongly modulated by the QBO phase. These results imply that the stratospheric conditions expressed by QBO significantly modulate the way the internal and external drivers affect the Northern Hemisphere winter climate.

Cod Collapse and Climate in the North Atlantic

NASA Astrophysics Data System (ADS)

Oremus, K. L.; Meng, K. C.; Gaines, S.

2016-02-01

Understanding the determinants of fish population dynamics is crucial to the recovery of many fisheries. Current research emphasizes the role of environmental conditions in driving fish populations, but the magnitude of and mechanisms behind these effects on crucial populations are not well established. Despite aggressive management efforts, New England cod fisheries have been in decline for several decades and have now reached unprecedented lows. We find a strong negative relationship between the North Atlantic Oscillation (NAO) and subsequent adult cod biomass and catch. In the Gulf of Maine fishery, a 1-unit NAO increase is associated with a 13% decrease in the biomass of age-1 cod the following year, a decrease that persists as the affected cohort matures. We further detect that a 1-unit NAO increase can lower commercial catch for up to 19 subsequent years, suggesting that fishing practices may be inadvertently exacerbating NAO's direct biological effects. These results imply that 18% and 32% of the overall decline in adult biomass and catch, respectively, since 1980 can be attributed to the NAO's recent multi-decadal positive phase. The Georges Bank cod fishery displays similar patterns. Because there is a delay between an NAO event and subsequent declines in adult biomass, our finding implies that already observed NAO events can be used in stock forecasts, providing lead time for adaptive policy. More broadly, our approach can inform forecasting efforts for other fisheries strongly affected by natural and anthropogenic climatic variation.

Linking North Atlantic Teleconnections to Latitudinal Variability of Wave Climate Along the North American Atlantic Coast

NASA Astrophysics Data System (ADS)

Provancha, C.; Adams, P. N.; Hegermiller, C.; Storlazzi, C. D.

2015-12-01

Shoreline change via coastal erosion and accretion is largely influenced by variations in ocean wave climate. Identifying the sources of these variations is challenging because the timing of wave energy delivery varies over multiple timescales within ocean basins. We present the results of an investigation of USACE Wave Information Studies hindcast hourly wave heights, periods, and directions along the North American Atlantic coast from 1980-2012, designed to explore links between wave climate and teleconnection patterns. Trends in median and extreme significant wave heights (SWHs) demonstrate that mean monthly SWHs increased from 1 to 5 cm/yr along the roughly 3000 km reach of study area, with changes in hurricane season waves appearing to be most influential in producing the overall trends. Distributions of SWHs categorized by North Atlantic Oscillation (NAO) phase, show that positive-period NAO SWHs are greater than negative-period NAO SWHs along the entire eastern seaboard (25°N to 45°N). The most prominent wave direction off Cape Cod, MA during positive-period NAO is approximately 105°, as compared to approximately 75° during negative-period NAO. Prominent wave directions between Cape Canaveral, FL, and Savannah, GA exhibit a similar shift but during opposite phases of the NAO. The results of this analysis suggest that the atmosphere-ocean interactions associated with contrasting NAO phases can significantly change the wave climate observed offshore along the North American Atlantic coast, altering alongshore wave energy fluxes and sediment transport patterns along the coast.

Forest productivity in southwestern Europe is controlled by coupled North Atlantic and Atlantic Multidecadal Oscillations.

PubMed

Madrigal-González, Jaime; Ballesteros-Cánovas, Juan A; Herrero, Asier; Ruiz-Benito, Paloma; Stoffel, Markus; Lucas-Borja, Manuel E; Andivia, Enrique; Sancho-García, Cesar; Zavala, Miguel A

2017-12-20

The North Atlantic Oscillation (NAO) depicts annual and decadal oscillatory modes of variability responsible for dry spells over the European continent. The NAO therefore holds a great potential to evaluate the role, as carbon sinks, of water-limited forests under climate change. However, uncertainties related to inconsistent responses of long-term forest productivity to NAO have so far hampered firm conclusions on its impacts. We hypothesize that, in part, such inconsistencies might have their origin in periodical sea surface temperature anomalies in the Atlantic Ocean (i.e., Atlantic Multidecadal Oscillation, AMO). Here we show strong empirical evidence in support of this hypothesis using 120 years of periodical inventory data from Iberian pine forests. Our results point to AMO + NAO + and AMO - NAO - phases as being critical for forest productivity, likely due to decreased winter water balance and abnormally low winter temperatures, respectively. Our findings could be essential for the evaluation of ecosystem functioning vulnerabilities associated with increased climatic anomalies under unprecedented warming conditions in the Mediterranean.

Solar forcing synchronizes decadal North Atlantic climate variability.

PubMed

Thiéblemont, Rémi; Matthes, Katja; Omrani, Nour-Eddine; Kodera, Kunihiko; Hansen, Felicitas

2015-09-15

Quasi-decadal variability in solar irradiance has been suggested to exert a substantial effect on Earth's regional climate. In the North Atlantic sector, the 11-year solar signal has been proposed to project onto a pattern resembling the North Atlantic Oscillation (NAO), with a lag of a few years due to ocean-atmosphere interactions. The solar/NAO relationship is, however, highly misrepresented in climate model simulations with realistic observed forcings. In addition, its detection is particularly complicated since NAO quasi-decadal fluctuations can be intrinsically generated by the coupled ocean-atmosphere system. Here we compare two multi-decadal ocean-atmosphere chemistry-climate simulations with and without solar forcing variability. While the experiment including solar variability simulates a 1-2-year lagged solar/NAO relationship, comparison of both experiments suggests that the 11-year solar cycle synchronizes quasi-decadal NAO variability intrinsic to the model. The synchronization is consistent with the downward propagation of the solar signal from the stratosphere to the surface.

Combined Effects of the North Atlantic Oscillation and the Arctic Oscillation on Sea Surface Temperature in the Alborán Sea

PubMed Central

Báez, José C.; Gimeno, Luis; Gómez-Gesteira, Moncho; Ferri-Yáñez, Francisco; Real, Raimundo

2013-01-01

We explored the possible effects of the North Atlantic Oscillation (NAO) and Arctic Oscillation (AO) on interannual sea surface temperature (SST) variations in the Alborán Sea, both separately and combined. The probability of observing mean annual SST values higher than average was related to NAO and AO values of the previous year. The effect of NAO on SST was negative, while that of AO was positive. The pure effects of NAO and AO on SST are obscuring each other, due to the positive correlation between them. When decomposing SST, NAO and AO in seasonal values, we found that variation in mean annual SST and mean winter SST was significantly related to the mean autumn NAO of the previous year, while mean summer SST was related to mean autumn AO of the previous year. The one year delay in the effect of the NAO and AO on the SST could be partially related to the amount of accumulated snow, as we found a significant correlation between the total snow in the North Alborán watershed for a year with the annual average SST of the subsequent year. A positive AO implies a colder atmosphere in the Polar Regions, which could favour occasional cold waves over the Iberian Peninsula which, when coupled with precipitations favoured by a negative NAO, may result in snow precipitation. This snow may be accumulated in the high peaks and melt down in spring-summer of the following year, which consequently increases the runoff of freshwater to the sea, which in turn causes a diminution of sea surface salinity and density, and blocks the local upwelling of colder water, resulting in a higher SST. PMID:23638005

Inter-Relationship Between Subtropical Pacific Sea Surface Temperature, Arctic Sea Ice Concentration, and the North Atlantic Oscillation in Recent Summers and Winters

NASA Technical Reports Server (NTRS)

Lim, Young-Kwon; Cullather, Richard I.; Nowicki, Sophie M.; Kim, Kyu-Myong

2017-01-01

The inter-relationship between subtropical western-central Pacific sea surface temperatures (STWCPSST), sea ice concentration in the Beaufort Sea (SICBS), and the North Atlantic Oscillation (NAO) are investigated for the last 37 summers and winters (1980-2016). Lag-correlation of the STWCPSST×(-1) in spring with the NAO phase and SICBS in summer increases over the last two decades, reaching r = 0.4-0.5 with significance at 5 percent, while winter has strong correlations in approximately 1985-2005. Observational analysis and the atmospheric general circulation model experiments both suggest that STWCPSST warming acts to increase the Arctic geopotential height and temperature in the following season. This atmospheric response extends to Greenland, providing favorable conditions for developing the negative phase of the NAO. SIC and surface albedo tend to decrease over the Beaufort Sea in summer, linked to the positive surface net shortwave flux. Energy balance considering radiative and turbulent fluxes reveal that available energy that can heat surface is larger over the Arctic and Greenland and smaller over the south of Greenland, in response to the STWCPSST warming in spring. XXXX Arctic & Atlantic: Positive upper-level height/T anomaly over the Arctic and Greenland, and a negative anomaly over the central-eastern Atlantic, resembling the (-) phase of the NAO. Pacific: The negative height/T anomaly over the mid-latitudes, along with the positive anomaly over the STWCP, where 1degC warming above climatology is prescribed. Discussion: It is likely that the Arctic gets warm and the NAO is in the negative phase in response to the STWCP warming. But, there are other factors (e.g., internal variability) that contribute to determination of the NAO phase: not always the negative phase of the NAO in the event of STWCP warming (e.g.: recent winters and near neutral NAO in 2017 summer).

75 FR 52292 - Airworthiness Directives; Diamond Aircraft Industries GmbH Models DA 40 and DA 40F Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-25

... Industries GmbH Models DA 40 and DA 40F Airplanes AGENCY: Federal Aviation Administration (FAA), Department... new airworthiness directive (AD) for all Diamond Aircraft Industries GmbH Models DA 40 and DA 40F... received information from Diamond Aircraft Industries GmbH that the Models DA 40 and DA 40F airplanes have...

Climate variability and marine ecosystem impacts: a North Atlantic perspective

NASA Astrophysics Data System (ADS)

Parsons, L. S.; Lear, W. H.

In recent decades it has been recognized that in the North Atlantic climatic variability has been largely driven by atmospheric forcing related to the North Atlantic Oscillation (NAO). The NAO index began a pronounced decline around 1950 to a low in the 1960s. From 1970 onward the NAO index increased to its most extreme and persistent positive phase during the late 1980s and early 1990s. Changes in the pattern of the NAO have differential impacts on the opposite sides of the North Atlantic and differential impacts in the north and south. The changes in climate resulting from changes in the NAO appear to have had substantial impacts on marine ecosystems, in particular, on fish productivity, with the effects varying from region to region. An examination of several species and stocks, e.g. gadoids, herring and plankton in the Northeast Atlantic and cod and shellfish in the Northwest Atlantic, indicates that there is a link between long-term trends in the NAO and the productivity of various components of the marine ecosystem. While broad trends are evident, the mechanisms are poorly understood. Further research is needed to improve our understanding of how this climate variability affects the productivity of various components of the North Atlantic marine ecosystem.

New England Cod Collapse and the Climate

PubMed Central

Meng, Kyle C.; Oremus, Kimberly L.; Gaines, Steven D.

2016-01-01

To improve fishery management, there is an increasing need to understand the long-term consequences of natural and anthropogenic climate variability for ecological systems. New England’s iconic cod populations have been in decline for several decades and have recently reached unprecedented lows. We find that 17% of the overall decline in Gulf of Maine cod biomass since 1980 can be attributed to positive phases of the North Atlantic Oscillation (NAO). This is a consequence of three results: i) a 1-unit increase in the NAO winter index is associated with a 17% decrease in the spring biomass of age-1 cod the following year; ii) this NAO-driven decrease persists as the affected cohort matures; iii) fishing practices appear to exacerbate NAO’s direct biological effect such that, since 1913, a 1-unit increase in the NAO index lowers subsequent cod catch for up to 19 years. The Georges Bank cod stock displays similar patterns. Because we statistically detect a delay between the NAO and subsequent declines in adult biomass, our findings imply that observed current NAO conditions can be used in stock forecasts, providing lead time for adaptive policy. More broadly, our approach can inform forecasting efforts for other fish populations strongly affected by natural and anthropogenic climatic variation. PMID:27463967

Contrasting spatial structures of Atlantic Multidecadal Oscillation between observations and slab ocean model simulations

NASA Astrophysics Data System (ADS)

Sun, Cheng; Li, Jianping; Kucharski, Fred; Xue, Jiaqing; Li, Xiang

2018-04-01

The spatial structure of Atlantic multidecadal oscillation (AMO) is analyzed and compared between the observations and simulations from slab ocean models (SOMs) and fully coupled models. The observed sea surface temperature (SST) pattern of AMO is characterized by a basin-wide monopole structure, and there is a significantly high degree of spatial coherence of decadal SST variations across the entire North Atlantic basin. The observed SST anomalies share a common decadal-scale signal, corresponding to the basin-wide average (i. e., the AMO). In contrast, the simulated AMO in SOMs (AMOs) exhibits a tripole-like structure, with the mid-latitude North Atlantic SST showing an inverse relationship with other parts of the basin, and the SOMs fail to reproduce the observed strong spatial coherence of decadal SST variations associated with the AMO. The observed spatial coherence of AMO SST anomalies is identified as a key feature that can be used to distinguish the AMO mechanism. The tripole-like SST pattern of AMOs in SOMs can be largely explained by the atmosphere-forced thermodynamics mechanism due to the surface heat flux changes associated with the North Atlantic Oscillation (NAO). The thermodynamic forcing of AMOs by the NAO gives rise to a simultaneous inverse NAO-AMOs relationship at both interannual and decadal timescales and a seasonal phase locking of the AMOs variability to the cold season. However, the NAO-forced thermodynamics mechanism cannot explain the observed NAO-AMO relationship and the seasonal phase locking of observed AMO variability to the warm season. At decadal timescales, a strong lagged relationship between NAO and AMO is observed, with the NAO leading by up to two decades, while the simultaneous correlation of NAO with AMO is weak. This lagged relationship and the spatial coherence of AMO can be well understood from the view point of ocean dynamics. A time-integrated NAO index, which reflects the variations in Atlantic meridional overturning

NGC 6535: the lowest mass Milky Way globular cluster with a Na-O anti-correlation? Cluster mass and age in the multiple population context

NASA Astrophysics Data System (ADS)

Bragaglia, A.; Carretta, E.; D'Orazi, V.; Sollima, A.; Donati, P.; Gratton, R. G.; Lucatello, S.

2017-11-01

To understand globular clusters (GCs) we need to comprehend how their formation process was able to produce their abundance distribution of light elements. In particular, we seek to figure out which stars imprinted the peculiar chemical signature of GCs. One of the best ways is to study the light-element anti-correlations in a large sample of GCs that are analysed homogeneously. As part of our spectroscopic survey of GCs with FLAMES, we present here the results of our study of about 30 red giant member stars in the low-mass, low-metallicity Milky Way cluster NGC 6535. We measured the metallicity (finding [Fe/H] =-1.95, rms = 0.04 dex in our homogeneous scale) and other elements of the cluster and, in particular, we concentrate here on O and Na abundances. These elements define the normal Na-O anti-correlation of classical GCs, making NGC 6535 perhaps the lowest mass cluster with a confirmed presence of multiple populations. We updated the census of Galactic and extragalactic GCs for which a statement on the presence or absence of multiple populations can be made on the basis of high-resolution spectroscopy preferentially, or photometry and low-resolution spectroscopy otherwise; we also discuss the importance of mass and age of the clusters as factors for multiple populations. Based on observations collected at ESO telescopes under programme 093.B-0583.Table 2 is only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/607/A44

An interannual link between Arctic sea-ice cover and the North Atlantic Oscillation

NASA Astrophysics Data System (ADS)

Caian, Mihaela; Koenigk, Torben; Döscher, Ralf; Devasthale, Abhay

2018-01-01

This work investigates links between Arctic surface variability and the phases of the winter (DJF) North Atlantic Oscillation (NAO) on interannual time-scales. The analysis is based on ERA-reanalysis and model data from the EC-Earth global climate model. Our study emphasizes a mode of sea-ice cover variability that leads the NAO index by 1 year. The mechanism of this leading is based on persistent surface forcing by quasi-stationary meridional thermal gradients. Associated thermal winds lead a slow adjustment of the pressure in the following winter, which in turn feeds-back on the propagation of sea-ice anomalies. The pattern of the sea-ice mode leading NAO has positive anomalies over key areas of South-Davis Strait-Labrador Sea, the Barents Sea and the Laptev-Ohkostsk seas, associated to a high pressure anomaly over the Canadian Archipelago-Baffin Bay and the Laptev-East-Siberian seas. These anomalies create a quasi-annular, quasi-steady, positive gradient of sea-ice anomalies about coastal line (when leading the positive NAO phase) and force a cyclonic vorticity anomaly over the Arctic in the following winter. During recent decades in spite of slight shifts in the modes' spectral properties, the same leading mechanism remains valid. Encouraging, actual models appear to reproduce the same mechanism leading model's NAO, relative to model areas of persistent surface forcing. This indicates that the link between sea-ice and NAO could be exploited as a potential skill-source for multi-year prediction by addressing the key problem of initializing the phase of the NAO/AO (Arctic Oscillation).

Local and regional effects of large scale atmospheric circulation patterns on winter wind power output in Western Europe

NASA Astrophysics Data System (ADS)

Zubiate, Laura; McDermott, Frank; Sweeney, Conor; O'Malley, Mark

2014-05-01

Recent studies (Brayshaw, 2009, Garcia-Bustamante, 2010, Garcia-Bustamante, 2013) have drawn attention to the sensitivity of wind speed distributions and likely wind energy power output in Western Europe to changes in low-frequency, large scale atmospheric circulation patterns such as the North Atlantic Oscillation (NAO). Wind speed variations and directional shifts as a function of the NAO state can be larger or smaller depending on the North Atlantic region that is considered. Wind speeds in Ireland and the UK for example are approximately 20 % higher during NAO + phases, and up to 30 % lower during NAO - phases relative to the long-term (30 year) climatological means. By contrast, in southern Europe, wind speeds are 15 % lower than average during NAO + phases and 15 % higher than average during NAO - phases. Crucially however, some regions such as Brittany in N.W. France have been identified in which there is negligible variability in wind speeds as a function of the NAO phase, as observed in the ERA-Interim 0.5 degree gridded reanalysis database. However, the magnitude of these effects on wind conditions is temporally and spatially non-stationary. As described by Comas-Bru and McDermott (2013) for temperature and precipitation, such non-stationarity is caused by the influence of two other patterns, the East Atlantic pattern, (EA), and the Scandinavian pattern, (SCA), which modulate the position of the NAO dipole. This phenomenon has also implications for wind speeds and directions, which has been assessed using the ERA-Interim reanalysis dataset and the indices obtained from the PC analysis of sea level pressure over the Atlantic region. In order to study the implications for power production, the interaction of the NAO and the other teleconnection patterns with local topography was also analysed, as well as how these interactions ultimately translate into wind power output. The objective is to have a better defined relationship between wind speed and power

Da Vinci-assisted abdominal cerclage.

PubMed

Barmat, Larry; Glaser, Gretchen; Davis, George; Craparo, Frank

2007-11-01

To report the first placement of an abdominal cervicoisthmic cerclage using the da Vinci robot. Case report. Tertiary-care hospital. A 39-year-old female with a history of cervical insufficiency who required a cerclage and was not a candidate for transvaginal cerclage placement. Abdominal cervicoisthmic cerclage placement using the da Vinci robot. Ability to safely and successfully place an abdominal cerclage using the da Vinci robot. Abdominal cerclage was successfully placed using the da Vinci robot. The patient had minimal blood loss and was discharged to home on the same day as surgery. Da Vinci robot-assisted abdominal cerclage placement is an innovative application of robotic surgery and may alter the standard of care for women who require this surgery.

Spectral studies of N-nonyl acridine orange in anionic, cationic and neutral surfactants

NASA Astrophysics Data System (ADS)

Wiosetek-Reske, Agnieszka M.; Wysocki, Stanisław

2006-08-01

The spectroscopic and photophysical properties of N-nonyl acridine orange - a metachromatic dye useful as a mitochondrial probe in living cells - are reported in water and microheterogeneous media: anionic sodium dodecylsulfate (SDS), cationic cetyltrimethylammonium bromide (CTAB) and neutral octylophenylpolyoxyethylene ether (TX-100). The spectral changes of N-nonyl acridine orange were observed in the presence of varying amount of SDS, CTAB and TX-100 and indicated formation of a dye-surfactant complex. The spectral changes were also regarded to be caused by the incorporation of dye molecules to micelles. It was proved by calculated values Kb and f in the following order: Kb TX-100 > Kb CTAB > Kb SDS and fTX-100 > fCTAB > fSDS. NAO binds to the micelle regardless the micellar charge. There are two types of interactions between NAO and micelles: hydrophobic and electrostatic. The hydrophobic interactions play a dominant role in binding of the dye to neutral TX-100. The unexpected fact of the binding NAO to cationic CTAB can be explained by a dominant role of hydrophobic interactions over electrostatic repulsion. Therefore, the affinity of NAO to CTAB is smaller than TX-100. Electrostatic interactions play an important role in binding of NAO to anionic micelles SDS. We observed a prolonged fluorescence lifetime after formation of the dye-surfactant complex τSDS > τTX-100 > τCTAB > τwater, the dye being protected against water in this environment. TX-100 is found to stabilize the excited state of NAO which is more polar than the ground state. Spectroscopic and photophysical properties of NAO will be helpful for a better understanding of the nature of binding and distribution inside mammalian cells.

The Influence of the North Atlantic Oscillation on Tropospheric Distributions of Ozone and Carbon Monoxide.

NASA Astrophysics Data System (ADS)

Knowland, K. E.; Doherty, R. M.; Hodges, K.

2015-12-01

The influence of the North Atlantic Oscillation (NAO) on the tropospheric distributions of ozone (O3) and carbon monoxide (CO) has been quantified. The Monitoring Atmospheric Composition and Climate (MACC) Reanalysis, a combined meteorology and composition dataset for the period 2003-2012 (Innes et al., 2013), is used to investigate the composition of the troposphere and lower stratosphere in relation to the location of the storm track as well as other meteorological parameters over the North Atlantic associated with the different NAO phases. Cyclone tracks in the MACC Reanalysis compare well to the cyclone tracks in the widely-used ERA-Interim Reanalysis for the same 10-year period (cyclone tracking performed using the tracking algorithm of Hodges (1995, 1999)), as both are based on the European Centre for Medium-Range Weather Forecasts' (ECMWF) Integrated Forecast System (IFS). A seasonal analysis is performed whereby the MACC reanalysis meteorological fields, O3 and CO mixing ratios are weighted by the monthly NAO index values. The location of the main storm track, which tilts towards high latitudes (toward the Arctic) during positive NAO phases to a more zonal location in the mid-latitudes (toward Europe) during negative NAO phases, impacts the location of both horizontal and vertical transport across the North Atlantic and into the Arctic. During positive NAO seasons, the persistence of cyclones over the North Atlantic coupled with a stronger Azores High promotes strong horizontal transport across the North Atlantic throughout the troposphere. In all seasons, significantly more intense cyclones occur at higher latitudes (north of ~50°C) during the positive phase of the NAO and in the southern mid-latitudes during the negative NAO phase. This impacts the location of stratospheric intrusions within the descending dry airstream behind the associated cold front of the extratropical cyclone and the venting of low-level pollution up into the free troposphere within

North Atlantic climate variability: The role of the North Atlantic Oscillation

NASA Astrophysics Data System (ADS)

Hurrell, James W.; Deser, Clara

2009-08-01

Marine ecosystems are undergoing rapid change at local and global scales. To understand these changes, including the relative roles of natural variability and anthropogenic effects, and to predict the future state of marine ecosystems requires quantitative understanding of the physics, biogeochemistry and ecology of oceanic systems at mechanistic levels. Central to this understanding is the role played by dominant patterns or "modes" of atmospheric and oceanic variability, which orchestrate coherent variations in climate over large regions with profound impacts on ecosystems. We review the spatial structure of extratropical climate variability over the Northern Hemisphere and, specifically, focus on modes of climate variability over the extratropical North Atlantic. A leading pattern of weather and climate variability over the Northern Hemisphere is the North Atlantic Oscillation (NAO). The NAO refers to a redistribution of atmospheric mass between the Arctic and the subtropical Atlantic, and swings from one phase to another producing large changes in surface air temperature, winds, storminess and precipitation over the Atlantic as well as the adjacent continents. The NAO also affects the ocean through changes in heat content, gyre circulations, mixed layer depth, salinity, high latitude deep water formation and sea ice cover. Thus, indices of the NAO have become widely used to document and understand how this mode of variability alters the structure and functioning of marine ecosystems. There is no unique way, however, to define the NAO. Several approaches are discussed including both linear (e.g., principal component analysis) and nonlinear (e.g., cluster analysis) techniques. The former, which have been most widely used, assume preferred atmospheric circulation states come in pairs, in which anomalies of opposite polarity have the same spatial structure. In contrast, nonlinear techniques search for recurrent patterns of a specific amplitude and sign. They reveal

North Atlantic climate variability: The role of the North Atlantic Oscillation

NASA Astrophysics Data System (ADS)

Hurrell, James W.; Deser, Clara

2010-02-01

Marine ecosystems are undergoing rapid change at local and global scales. To understand these changes, including the relative roles of natural variability and anthropogenic effects, and to predict the future state of marine ecosystems requires quantitative understanding of the physics, biogeochemistry and ecology of oceanic systems at mechanistic levels. Central to this understanding is the role played by dominant patterns or "modes" of atmospheric and oceanic variability, which orchestrate coherent variations in climate over large regions with profound impacts on ecosystems. We review the spatial structure of extratropical climate variability over the Northern Hemisphere and, specifically, focus on modes of climate variability over the extratropical North Atlantic. A leading pattern of weather and climate variability over the Northern Hemisphere is the North Atlantic Oscillation (NAO). The NAO refers to a redistribution of atmospheric mass between the Arctic and the subtropical Atlantic, and swings from one phase to another producing large changes in surface air temperature, winds, storminess and precipitation over the Atlantic as well as the adjacent continents. The NAO also affects the ocean through changes in heat content, gyre circulations, mixed layer depth, salinity, high latitude deep water formation and sea ice cover. Thus, indices of the NAO have become widely used to document and understand how this mode of variability alters the structure and functioning of marine ecosystems. There is no unique way, however, to define the NAO. Several approaches are discussed including both linear (e.g., principal component analysis) and nonlinear (e.g., cluster analysis) techniques. The former, which have been most widely used, assume preferred atmospheric circulation states come in pairs, in which anomalies of opposite polarity have the same spatial structure. In contrast, nonlinear techniques search for recurrent patterns of a specific amplitude and sign. They reveal

The local effect of octreotide on mechanical pain sensitivity is more sensitive in DA rats than DA.1U rats.

PubMed

Yao, Fan-Rong; Wang, Hui-Sheng; Guo, Yuan; Zhao, Yan

2016-02-01

A recent study by the authors indicated that major histocompatibility complex (MHC) genes are associated with the differences in basal pain sensitivity and in formalin model between Dark-Agouti (DA) and novel congenic DA.1U rats, which have the same genetic background as DA rats except for the u alleles of MHC. The objective of the present study is to investigate whether there is a difference in the pristane-induced arthritis (PIA) model and local analgesic effect of octreotide (OCT) between DA and DA.1U rats. The hindpaw mechanical withdrawal threshold (MWT) and heat withdrawal latency (HWL) were observed. The C unit firings of the tibial nerve evoked by non-noxious and noxious toe movements were recorded by electrophysiological methods in normal and PIA models in DA and DA.1U rats before and after local OCT administration. The expression of somatostatin receptor 2A (SSTR2A) was observed by immunohistochemistry. The results demonstrate that DA rats have a higher mechanical sensitivity than DA.1U rats after PIA. Local OCT administration significantly elevated MWT in DA rats under normal and PIA sate, but not in DA.1U rats. The electrophysiological experiments showed OCT significantly attenuated the firings of C units evoked by non-noxious and noxious stimulation in DA rats more than those in DA.1U rats both in normal and PIA states. In addition, the expression of SSTR2A in the dorsal horn of the spinal cord was significantly higher in DA than in DA.1U rats. All of the findings suggest a higher local analgesic effect of OCT in DA rats than DA.1U rats, which might be associated with the MHC genes. © 2016 John Wiley & Sons Australia, Ltd.

75 FR 75868 - Airworthiness Directives; Diamond Aircraft Industries GmbH Models DA 40 and DA 40F Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-07

... Airworthiness Directives; Diamond Aircraft Industries GmbH Models DA 40 and DA 40F Airplanes AGENCY: Federal... of the Thielert Engine Owners Group commented that the Model DA 42 has the same door design and the same unsafe condition. He recommended that the AD also apply to the Model DA 42. The FAA has discussed...

Global climate change and reindeer: effects of winter weather on the autumn weight and growth of calves.

PubMed

Weladji, Robert B; Holand, Øystein

2003-07-01

Reindeer/caribou (Rangifer tarandus), which constitute a biological resource of vital importance for the physical and cultural survival of Arctic residents, and inhabit extremely seasonal environments, have received little attention in the global change debate. We investigated how body weight and growth rate of reindeer calves were affected by large-scale climatic variability [measured by the North Atlantic Oscillation (NAO) winter index] and density in one population in central Norway. Body weights of calves in summer and early winter, as well as their growth rate (summer to early winter), were significantly influenced by density and the NAO index when cohorts were in utero. Males were heavier and had higher absolute growth than females, but there was no evidence that preweaning condition of male and female calves were influenced differently by the NAO winter index. Increasing NAO index had a negative effect on calves' body weight and growth rate. Increasing density significantly reduced body weight and growth rate of calves, and accentuated the effect of the NAO winter index. Winters with a higher NAO index are thus severe for reindeer calves in this area and their effects are associated with nutritional stress experienced by the dams during pregnancy or immediately after calving. Moreover, increased density may enhance intra-specific competition and limits food available at the individual level within cohorts. We conclude that if the current pattern of global warming continues, with greater change occurring in northern latitudes and during winter as is predicted, reduced body weight of reindeer calves may be a consequence in areas where winters with a high NAO index are severe. This will likely have an effect on the livelihood of many northern indigenous peoples, both economically and culturally.

The changing relationship between the December North Atlantic Oscillation and the following February East Asian trough before and after the late 1980s

NASA Astrophysics Data System (ADS)

Feng, Guolin; Zou, Meng; Qiao, Shaobo; Zhi, Rong; Gong, Zhiqiang

2018-03-01

This study investigates the changing relationship between the December North Atlantic Oscillation (NAO) and the following February East Asian trough (EAT) throughout the past 60 years. We found that the relationship between the December NAO and the following February EAT is significantly enhanced after the late 1980s compared with the period before the late 1980s. The changing relationship mainly results from the enhanced relationship between the December NAO and the following February North Atlantic mid-latitudes' sea surface temperature (SST) anomalies (NAMA) during the same period. During the period after the late 1980s, the persistent positive (negative) NAO pattern from December to the following January contributes to a positive (negative) NAMA, which reaches its maximum magnitude in the following February and excites an anomalous wave train along the North Atlantic and northern Eurasia, and significantly impacts the EAT. During the period before the late 1980s, the positive (negative) NAO pattern during December cannot persist into the following January, and the related positive (negative) NAMA is insignificant during the following February, causing the response of the simultaneous EAT to be insignificant as well. Moreover, there exists a significant impact of the December NAO on the December-January NAMA after the late 1980s, while the December-January NAMA is relatively less affected by the December NAO before the late 1980s. As a result, the simultaneous response of the atmospheric circulation anomalies to the December-January NAMA are evident before the late 1980s, and the positive (negative) NAMA can excite an anomalous wave train along the North Atlantic and northern Eurasia and significantly deepen (shallow) the downstream EAT. By contrast, after involving a feature of atmosphere forcing of SST, the simultaneous feedback of the December-January NAMA on EAT is significantly decreased after the 1980s.

Challenging a 15-year-old claim: The North Atlantic Oscillation index as a predictor of spring migration phenology of birds.

PubMed

Haest, Birgen; Hüppop, Ommo; Bairlein, Franz

2018-04-01

Many migrant bird species that breed in the Northern Hemisphere show advancement in spring arrival dates. The North Atlantic Oscillation (NAO) index is one of the climatic variables that have been most often investigated and shown to be correlated with these changes in spring arrival. Although the NAO is often claimed to be a good predictor or even to have a marked effect on interannual changes in spring migration phenology of Northern Hemisphere breeding birds, the results on relations between spring migration phenology and NAO show a large variety, ranging from no, over weak, to a strong association. Several factors, such as geographic location, migration phase, and the NAO index time window, have been suggested to partly explain these observed differences in association. A combination of a literature meta-analysis, and a meta-analysis and sliding time window analysis of a dataset of 23 short- and long-distance migrants from the constant-effort trapping garden at Helgoland, Germany, however, paints a completely different picture. We found a statistically significant overall effect size of the NAO on spring migration phenology (coefficient = -0.14, SE = 0.054), but this on average only explains 0%-6% of the variance in spring migration phenology across all species. As such, the value and biological meaning of the NAO as a general predictor or explanatory variable for climate change effects on migration phenology of birds, seems highly questionable. We found little to no definite support for previously suggested factors, such as geographic location, migration phenology phase, or the NAO time window, to explain the heterogeneity in correlation differences. We, however, did find compelling evidence that the lack of accounting for trends in both time series has led to strongly inflated (spurious) correlations in many studies (coefficient = -0.13, SE = 0.019). © 2017 John Wiley & Sons Ltd.

Protective effects of traditional Chinese medicine formula NaoShuanTong capsule on haemorheology and cerebral energy metabolism disorders in rats with blood stasis.

PubMed

Liu, Hong; Peng, Yao-Yao; Liang, Feng-Yin; Chen, Si; Li, Pei-Bo; Peng, Wei; Liu, Zhong-Zheng; Xie, Cheng-Shi; Long, Chao-Feng; Su, Wei-Wei

2014-01-02

NaoShuanTong capsule (NSTC), an oral traditional Chinese medicine formula, is composed of Pollen Typhae , Radix Paeoniae Rubra , Rhizoma Gastrodiae , Radix Rhapontici and Radix Curcumae . It has been widely used to treat ischemic stroke in clinic for many years in China. In addition to neuronal apoptosis, haemorheology and cerebral energy metabolism disorders also play an important role in the pathogenesis and development of ischemic stroke. The present study was designed to evaluate the in vivo protective effects of NSTC on haemorheology and cerebral energy metabolism disorders in rats with blood stasis. Sixty specific pathogen-free sprague-dawley rats, male only, were randomly divided into six groups (control group, model group, aspirin (100 mg/kg/d) group, NSTC low-dose (400 mg/kg/d) group, NSTC intermediate-dose (800 mg/kg/d) group, NSTC high-dose (1600 mg/kg/d) group) with 10 animals in each. The rats except those in the control group were placed in ice-cold water (0-4 °C) for 5 min during the time interval (4 h) of two adrenaline hydrochloride injections (0.8 mg/kg) to induce blood stasis. After treatment, whole blood viscosity at three shear rates, plasma viscosity and erythrocyte sedimentation rate significantly decreased in NSTC intermediate- and high-dose groups; erythrocyte aggregation index and red corpuscle electrophoresis index significantly decreased in all the three dose NSTC groups. Moreover, treatment with high-dose NSTC could significantly improve Na + -K + adenosine triphosphatase (ATPase) and Ca 2+ ATPase activity, as well as lower lactic acid level in brain tissues. These results demonstrated the protective effects of NSTC on haemorheology and cerebral energy metabolism disorders, which may provide scientific information for the further understanding of mechanism(s) of NSTC as a clinical treatment for ischemic stroke. Furthermore, the protective effects of activating blood circulation as observed in this study might create valuable

da Vinci decoded: does da Vinci stereopsis rely on disparity?

PubMed

Tsirlin, Inna; Wilcox, Laurie M; Allison, Robert S

2012-11-01

In conventional stereopsis, the depth between two objects is computed based on the retinal disparity in the position of matching points in the two eyes. When an object is occluded by another object in the scene, so that it is visible only in one eye, its retinal disparity cannot be computed. Nakayama and Shimojo (1990) found that a precept of quantitative depth between the two objects could still be established for such stimuli and proposed that this precept is based on the constraints imposed by occlusion geometry. They named this and other occlusion-based depth phenomena "da Vinci stereopsis." Subsequent research found quantitative depth based on occlusion geometry in several other classes of stimuli grouped under the term da Vinci stereopsis. However, Nakayama and Shimojo's findings were later brought into question by Gillam, Cook, and Blackburn (2003), who suggested that quantitative depth in their stimuli was perceived based on conventional disparity. In order to understand whether da Vinci stereopsis relies on one type of mechanism or whether its function is stimulus dependent we examine the nature and source of depth in the class of stimuli used by Nakayama and Shimojo (1990). We use three different psychophysical and computational methods to show that the most likely source for depth in these stimuli is occlusion geometry. Based on these experiments and previous data we discuss the potential mechanisms responsible for processing depth from monocular features in da Vinci stereopsis.

Effect of 14-kDa and 47-kDa protein molecules of age garlic extract on peritoneal macrophages.

PubMed

Daneshmandi, Saeed; Hajimoradi, Monire; Ahmadabad, Hasan Namdar; Hassan, Zuhair Mohammad; Roudbary, Maryam; Ghazanfari, Tooba

2011-03-01

Garlic (Allium sativum), traditionally being used as a spice worldwide, has different applications and is claimed to possess beneficial effects in several health ailments such as tumor and atherosclerosis. Garlic is also an immunomodulator and its different components are responsible for different properties. The present work aimed to assess the effect of protein fractions of garlic on peritoneal macrophages. 14-kDa and 47-kDa protein fractions of garlic were purified. Mice peritoneal macrophages were lavaged and cultured in a microtiter plate and exposed to different concentrations of garlic proteins. MTT assay was performed to evaluate the viability of macrophage. The amount of nitric oxide (NO) was detected in culture supernatants of macrophages by Griess reagent and furthermore, the cytotoxicity study of culture supernatants was carried out on WEHI-164 fibrosarcoma cell line as tumor necrosis factor-α bioassay. MTT assay results for both 14-kDa and 47-kDa protein fractions of stimulated macrophages were not significant (P > 0.05). Both 14-kDa and 47-kDa fractions significantly suppressed production of NO from macrophages (P = 0.007 and P = 0.003, respectively). Cytotoxicity of macrophages' supernatant on WEHI-164 fibrosarcoma cells was not affected by garlic protein fractions (P = 0.066 for 14-kDa and P = 0.085 for 47-kDa fractions). according to our finding, 14-kDa and 47-kDa fractions of aged garlic extract are able to suppress NO production from macrophages, which can be used as a biological advantage. These molecules had no cytotoxic effect on macrophages and do not increase tumoricidal property of macrophages.

Reconstructing Late Holocene North Atlantic atmospheric circulation changes using functional paleoclimate networks

NASA Astrophysics Data System (ADS)

Franke, Jasper G.; Werner, Johannes P.; Donner, Reik V.

2017-11-01

Obtaining reliable reconstructions of long-term atmospheric circulation changes in the North Atlantic region presents a persistent challenge to contemporary paleoclimate research, which has been addressed by a multitude of recent studies. In order to contribute a novel methodological aspect to this active field, we apply here evolving functional network analysis, a recently developed tool for studying temporal changes of the spatial co-variability structure of the Earth's climate system, to a set of Late Holocene paleoclimate proxy records covering the last two millennia. The emerging patterns obtained by our analysis are related to long-term changes in the dominant mode of atmospheric circulation in the region, the North Atlantic Oscillation (NAO). By comparing the time-dependent inter-regional linkage structures of the obtained functional paleoclimate network representations to a recent multi-centennial NAO reconstruction, we identify co-variability between southern Greenland, Svalbard, and Fennoscandia as being indicative of a positive NAO phase, while connections from Greenland and Fennoscandia to central Europe are more pronounced during negative NAO phases. By drawing upon this correspondence, we use some key parameters of the evolving network structure to obtain a qualitative reconstruction of the NAO long-term variability over the entire Common Era (last 2000 years) using a linear regression model trained upon the existing shorter reconstruction.

Changes in North Atlantic Oscillation drove Population Migrations and the Collapse of the Western Roman Empire.

PubMed

Drake, B Lee

2017-04-27

Shifts in the North Atlantic Oscillation (NAO) from 1-2 to 0-1 in four episodes increased droughts on the Roman Empire's periphery and created push factors for migrations. These climatic events are associated with the movements of the Cimbri and Teutones from 113-101 B.C., the Marcomanni and Quadi from 164 to 180 A.D., the Goths in 376 A.D., and the broad population movements of the Migration Period from 500 to 600 A.D. Weakening of the NAO in the instrumental record of the NAO have been associated with a shift to drought in the areas of origin for the Cimbri, Quadi, Visigoths, Ostrogoths, Huns, and Slavs. While other climate indices indicate deteriorating climate after 200 A.D. and cooler conditions after 500 A.D., the NAO may indicate a specific cause for the punctuated history of migrations in Late Antiquity. Periodic weakening of the NAO caused drought in the regions of origin for tribes in antiquity, and may have created a powerful push factor for human migration. While climate change is frequently considered as a threat to sustainability, its role as a conflict amplifier in history may be one of its largest impacts on populations.

Measurement of Mitochondrial Mass by Flow Cytometry during Oxidative Stress.

PubMed

Doherty, Edward; Perl, Andras

2017-07-01

Properly assessing mitochondrial health is crucial to understand their role in disease. MitoTracker green (MTG) and nonylacridine orange (NAO) are fluorescent probes which have been commonly used to assess mitochondrial mass. This is based on the assumption that both MTG and NAO accumulate in mitochondria regardless of the mitochondrial transmembrane potential (ΔΨ m ). Here, we utilized flow cytometry to evaluate the performance of these probes for assessment of mitochondrial mass relative to forward (FSC) and side scatter (SSC) in human peripheral blood lymphocytes (PBL). In isolated mitochondria, two subpopulations were identified by FSC and SSC measurements which were matched to subpopulations stained by MTG and NAO. The performance of these dyes was examined under oxidative and nitrosative stress induced by rotenone and NOC-18 while N -acetylcysteine (NAC) was employed as an antioxidant. Production of reactive oxygen species (ROS) and ΔΨ m were monitored in parallel. With respect to representation of mitochondrial mass, neither MTG nor NAO was affected by ΔΨ m . However, MTG showed significant correlation with cytosolic and mitochondrial ROS production and nitrosative stress. Our data suggest that NAO may be more suitable than MTG for assessment of mitochondrial mass by flow cytometry during oxidative stress.

Volcanic forcing of the North Atlantic Oscillation over the last 2,000 years

NASA Astrophysics Data System (ADS)

Breitenbach, Sebastian F. M.; Ridley, Harriet E.; Lechleitner, Franziska A.; Asmerom, Yemane; Rehfeld, Kira; Prufer, Keith M.; Kennett, Douglas J.; Aquino, Valorie V.; Polyak, Victor; Goswami, Bedartha; Marwan, Norbert; Haug, Gerald H.; Baldini, James U. L.

2015-04-01

The North Atlantic Oscillation (NAO) is a principal mode of atmospheric circulation in the North Atlantic realm (Hurrell et al. 2003) and influences rainfall distribution over Europe, North Africa and North America. Although observational data inform us on multi-annual variability of the NAO, long and detailed paleoclimate datasets are required to understand the mechanisms and full range of its variability and the spatial extent of its influence. Chronologies of available proxy-based NAO reconstructions are often interdependent and cover only the last ~1,100 years, while longer records are characterized by low sampling resolution and chronological constraints. This complicates the reconstruction of regional responses to NAO changes. We present data from a 2,000 year long sub-annual carbon isotope record from speleothem YOK-I from Yok Balum Cave, Belize, Central America. YOK-I has been extensively dated using U-series (Kennett et al. 2012). Monitoring shows that stalagmite δ13C in Yok Balum cave is governed by infiltration changes associated with tropical wet season rainfall. Higher (lower) δ13C values reflect drier (wetter) conditions related to Intertropical Convergence Zone position and trade winds intensity. Comparison with NAO reconstructions (Proctor et al. 2000, Trouet et al. 2009, Wassenburg et al. 2013) reveals that YOK-I δ13C sensitively records NAO-related rainfall dynamics over Belize. The Median Absolute Deviation (MAD) of δ13C extends NAO reconstructions to the last 2,000 years and indicates that high latitude volcanic aerosols force negative NAO phases. We infer that volcanic aerosols modify inter-hemispheric temperature contrasts at multi-annual scale, resulting in meridional relocation of the ITCZ and the Bermuda-Azores High, altering NAO and tropical rainfall patterns. Decade-long dry periods in the 11th and the late 18th century relate to major high northern latitude eruptions and exemplify the climatic response to volcanic forcing by

Properties of self-assembled diluted magnetic semiconductor nanostructures =

NASA Astrophysics Data System (ADS)

Ankiewicz, Amelia Olga Goncalves

Este trabalho centra-se na investigacao da possibilidade de se conseguir um semicondutor magnetico diluido (SMD) baseado em ZnO. Foi levado a cabo um estudo detalhado das propriedades magneticas e estruturais de estruturas de ZnO, nomeadamente nanofios (NFs), nanocristais (NCs) e filmes finos, dopadas com metais de transicao (MTs). Foram usadas varias tecnicas experimentais para caracterizar estas estruturas, designadamente difraccao de raios-X, microscopia electronica de varrimento, ressonancia magnetica, SQUID, e medidas de transporte. Foram incorporados substitucionalmente nos sitios do Zn ioes de Mn2+ e Co2+ em ambos os NFs e NCs de ZnO. Revelou-se para ambos os ioes dopantes, que a incorporacao e heterogenea, uma vez que parte do sinal de ressonancia paramagnetica electronica (RPE) vem de ioes de MTs em ambientes distorcidos ou enriquecidos com MTs. A partir das intensidades relativas dos espectros de RPE e de modificacoes da superficie, demonstra-se ainda que os NCs exibem uma estrutura core-shell. Os resultados, evidenciam que, com o aumento da concentracao de MTs, a dimensao dos NCs diminui e aumentam as distorcoes da rede. Finalmente, no caso dos NCs dopados com Mn, obteve-se o resultado singular de que a espessura da shell e da ordem de 0.3 nm e de que existe uma acumulacao de Mn na mesma. Com o objectivo de esclarecer o papel dos portadores de carga na medicao das interaccoes ferromagneticas, foram co-dopados filmes de ZnO com Mn e Al ou com Co e Al. Os filmes dopados com Mn, revelaram-se simplesmente paramagneticos, com os ioes de Mn substitucionais nos sitios do Zn. Por outro lado, os filmes dopados com Co exibem ferromagnetismo fraco nao intrinseco, provavelmente devido a decomposicao spinodal. Foram ainda efectuados estudos comparativos com filmes de ligas de Zn1-xFexO. Como era de esperar, detectaram-se segundas fases de espinela e de oxido de ferro nestas ligas; todas as amostras exibiam curvas de histerese a 300 K. Estes resultados suportam a

Sodium-Oxygen Battery: Steps Toward Reality.

PubMed

Landa-Medrano, Imanol; Li, Chunmei; Ortiz-Vitoriano, Nagore; Ruiz de Larramendi, Idoia; Carrasco, Javier; Rojo, Teófilo

2016-04-07

Rechargeable metal-oxygen batteries are receiving significant interest as a possible alternative to current state of the art lithium ion batteries due to their potential to provide higher gravimetric energies, giving significantly lighter or longer-lasting batteries. Recent advances suggest that the Na-O2 battery, in many ways analogous to Li-O2 yet based on the reversible formation of sodium superoxide (NaO2), has many advantages such as a low charge overpotential (∼100 mV) resulting in improved efficiency. In this Perspective, we discuss the current state of knowledge in Na-O2 battery technology, with an emphasis on the latest experimental studies, as well as theoretical models. We offer special focus on the principle outstanding challenges and issues and address the advantages/disadvantages of the technology when compared with Li-O2 batteries as well as other state-of-the-art battery technologies. We finish by detailing the direction required to make Na-O2 batteries both commercially and technologically viable.

The North Atlantic Oscillation system and plant phenology

NASA Astrophysics Data System (ADS)

Hubálek, Zdenek

2016-05-01

The onset of flowering in 78 wild and domesticated terrestrial plant species recorded in South Moravia (Czech Republic) from 1965 to 2014 was correlated with the North Atlantic Oscillation (NAO) index of the preceding winter. Flowering occurred significantly earlier following positive winter NAO phases (causing spring to be warmer than normal in Central Europe) in nearly all early-flowering (March, April) species; high Pearson correlation values were recorded in, e.g., goat willow, spring snowflake, golden bell, cornelian cherry, sweet violet, cherry plum, grape hyacinth, apricot, blackthorn, common dandelion, cherry, southern magnolia, common apple, cuckoo flower, European bird cherry, and cherry laurel. In contrast, the timing of later-flowering plant species (May to July) did not correlate significantly with the winter NAO index. It was found that local temperature is obviously a proximate factor of plant phenology, while the winter NAO is the ultimate factor, affecting temperature and other meteorological phenomena in Central Europe during spring season.

Identification of entomopathogenic nematodes and symbiotic bacteria from Nam Nao National Park in Thailand and larvicidal activity of symbiotic bacteria against Aedes aegypti and Aedes albopictus.

PubMed

Yooyangket, Temsiri; Muangpat, Paramaporn; Polseela, Raxsina; Tandhavanant, Sarunporn; Thanwisai, Aunchalee; Vitta, Apichat

2018-01-01

Entomopathogenic nematodes (EPNs) that are symbiotically associated with Xenorhabdus and Photorhabdus bacteria can kill target insects via direct infection and toxin action. There are limited reports identifying such organisms in the National Park of Thailand. Therefore, the objectives of this study were to identify EPNs and symbiotic bacteria from Nam Nao National Park, Phetchabun Province, Thailand and to evaluate the larvicidal activity of bacteria against Aedes aegypti and Ae. albopictus. A total of 12 EPN isolates belonging to Steinernema and Heterorhabditis were obtained form 940 soil samples between February 2014 and July 2016. EPNs were molecularly identified as S. websteri (10 isolates) and H. baujardi (2 isolates). Symbiotic bacteria were isolated from EPNs and molecularly identified as P. luminescens subsp. akhurstii (13 isolates), X. stockiae (11 isolates), X. vietnamensis (2 isolates) and X. japonica (1 isolate). For the bioassay, bacterial suspensions were evaluated for toxicity against third to early fourth instar larvae of Aedes spp. The larvae of both Aedes species were orally susceptible to symbiotic bacteria. The highest larval mortality of Ae. aegypti was 99% after exposure to X. stockiae (bNN112.3_TH) at 96 h, and the highest mortality of Ae. albopictus was 98% after exposure to P. luminescens subsp. akhurstii (bNN121.4_TH) at 96 h. In contrast to the control groups (Escherichia coli and distilled water), the mortality rate of both mosquito larvae ranged between 0 and 7% at 72 h. Here, we report the first observation of X. vietnamensis in Thailand. Additionally, we report the first observation of P. luminescens subsp. akhurstii associated with H. baujardi in Thailand. X. stockiae has potential to be a biocontrol agent for mosquitoes. This investigation provides a survey of the basic diversity of EPNs and symbiotic bacteria in the National Park of Thailand, and it is a bacterial resource for further studies of bioactive compounds.

The variability of the North Atlantic Oscillation throughout the Holocene

NASA Astrophysics Data System (ADS)

Wassenburg, Jasper; Dietrich, Stephan; Fietzke, Jan; Fohlmeister, Jens; Wei, Wei; Jochum, Klaus Peter; Scholz, Denis; Richter, Detlev; Sabaoui, Abdellah; Lohmann, Gerrit; Andreae, Meinrat; Immenhauser, Adrian

2013-04-01

The North Atlantic Oscillation (NAO) has a major impact on Northern Hemisphere winter climate. Trouet et al. (2009) reconstructed the NAO for the last millennium based on a Moroccan tree ring PDSI (Palmer Drought Severity Index) reconstruction and a Scottish speleothem record. More recently, Olsen et al. (2012) extended the NAO record back to 5.2 ka BP based on a lake record from West Greenland. It is, however, well known that the NAO exhibits non-stationary behavior and the use of a single location for a NAO reconstruction may not capture the complete variability. In addition, the imprint of the NAO on European rainfall patterns in the Early and Mid Holocene on (multi-) centennial timescales is still largely unknown. This is related to difficulties in establishing robust correlations between different proxy records and the fact that proxies may not only reflect winter conditions (i.e., the season when the NAO has the largest influence). Here we present a precisely dated, high resolution speleothem δ18O record from NW Morocco covering the complete Early and Mid Holocene. Carbon and oxygen isotopes were measured at a resolution of 15 years. A multi-proxy approach provides solid evidence that speleothem δ18O values reflect changes in past rainfall intensity. The Moroccan record shows a significant correlation with a speleothem rainfall record from western Germany, which covers the entire Holocene (Fohlmeister et al., 2012). The combination with the extended speleothem record from Scotland, speleothem records from north Italy and the NAO reconstruction from West Greenland (Olsen et al., 2012) allows us to study the variability of the NAO during the entire Holocene. The relation between West German and Northwest Moroccan rainfall has not been stationary, which is evident from the changing signs of correlation. The Early Holocene is characterized by a positive correlation, which changes between 9 and 8 ka BP into a negative correlation. Simulations with the state

Dynapenic obesity as an associated factor to lipid and glucose metabolism disorders and metabolic syndrome in older adults - Findings from SABE Study.

PubMed

Alexandre, Tiago da Silva; Aubertin-Leheudre, Mylène; Carvalho, Lívia Pinheiro; Máximo, Roberta de Oliveira; Corona, Ligiana Pires; Brito, Tábatta Renata Pereira de; Nunes, Daniella Pires; Santos, Jair Licio Ferreira; Duarte, Yeda Aparecida de Oliveira; Lebrão, Maria Lúcia

2018-08-01

There is little evidence showing that dynapenic obesity is associated with lipid and glucose metabolism disorders, high blood pressure, chronic disease and metabolic syndrome. Our aim was to analyze whether dynapenic abdominal obesity can be associated with lipid and glucose metabolism disorders, high blood pressure, metabolic syndrome and cardiovascular diseases in older adults living in São Paulo. This cross-sectional study included 833 older adults who took part of the third wave of the Health, Well-being and Aging Study in 2010. Based on waist circumference (>88 cm women and >102 cm men) and handgrip strength (<16 kg women and <26 kg men), four groups were identified: non-dynapenic/non-abdominal obese (ND/NAO), abdominal obese alone (AOA), dynapenic alone (DA) and dynapenic/abdominal obese (D/AO). Dependent variables were blood pressure, lipid profile, fasting glucose and glycated-haemoglobin, metabolic syndrome and cardiovascular diseases. Logistic regression was used to analyze the associations between dynapenia and abdominal obesity status and lipid and glucose metabolic profiles, blood pressure, cardiovascular diseases and metabolic syndrome. The fully adjusted models showed that D/AO individuals had higher prevalence of low HDL plasma concentrations (OR = 2.51, 95%CI: 1.40-4.48), hypertriglyceridemia (OR = 2.53, 95%CI: 1.43-4.47), hyperglycemia (OR = 2.05, 95%CI: 1.14-3.69), high glycated-haemoglobin concentrations (OR = 1.84, 95%CI: 1.03-3.30) and metabolic syndrome (OR = 12.39, 95%CI: 7.38-20.79) than ND/NAO. Dynapenic and D/AO individuals had higher prevalence of heart disease (OR = 2.05, 95%CI: 1.17-3.59 and OR = 1.92, 95%CI: 1.06-3.48, respectively) than ND/NAO. D/AO was associated with high prevalence of lipid and glucose metabolism disorders and metabolic syndrome while dynapenia and D/AO were associated with high prevalence of heart disease. Copyright © 2017 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism

77 FR 33980 - National Appeals Office Rules of Procedure

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-08

... National Appeals Office (NAO), a division of NMFS' Office of Management and Budget within NOAA. NAO's... Section 303A of the Magnuson-Steven Fishery Conservation and Management Act. The proposed procedures could... Goodman, National Appeals Office, Office of Management and Budget, NMFS, 1315 East West Hwy., Room 9553...

In vivo pharmacokinetic comparisons of ferulic acid and puerarin after oral administration of monomer, medicinal substance aqueous extract and Nao-De-Sheng to rats

PubMed Central

Ouyang, Zhen; Zhao, Ming; Tang, Jianming; Pan, Lulin

2012-01-01

Background: Nao-De-Sheng decoction (NDS), a traditional Chinese medicine (TCM) prescription containing Radix puerariae lobatae, Floscarthami, Radix et Rhizoma Notoginseng, Rhizoma chuanxiong and Fructus crataegi, is effective in the treatment of cerebral arteriosclerosis, ischemic cerebral stroke and apoplexy linger effect. Ferulic acid and puerarin are the main absorbed effective ingredients of NDS. Objective: To assess the affection of other components in medical material and compound recipe compatibility on the pharmacokinetics of ferulaic acid and puerarin, of ferulic acid from the monomer Rhizoma chuanxiong aqueous extract and NDS were studied. And pharmacokinetics comparisons of puerarin from the monomer Radix puerariae extract and NDS decoction were investigated simultaneously. Materials and Methods: At respective different time points after oral administration of the monomer, medicinal substance aqueous extract and NDS at the same dose in rats, plasma concentrations of ferulic acid and puerarin in rats were determined by RP-HPLC, and the main pharmacokinetic parameters were estimated with 3P97 software. Results: The plasma concentration-time curves of ferulaic acid and puerarin were both best fitted with a two-compartment model. AUC0−t, AUC0→∞, Tmax, and Cmax of ferulic acid in the monomer and NDS decoction were increased significantly (P < 0.05) compared with that in Rhizoma chuanxiong aqueous extract. And statistically significant increase (P < 0.05) in pharmacokinetic parameters of puerarin including AUC0−t, AUC0→∞, CL, Tmax and Cmax were obtained after oral administration of puerarin monomer compared with Radix puerariae extract. Although the changes of AUC0−t, AUC0→∞ and CL had no statistically significant, Cmax of puerarin in NDS was increased remarkably (P < 0.05) compared with that in single puerarin. Conclusions: Some ingredients of Rhizoma chuanxiong and Radix puerariae may be suggested to remarkably influence plasma

The da Vinci robot.

PubMed

Moran, Michael E

2006-12-01

One might assume from the title of this paper that the nuances of a complex mechanical robot will be discussed, and this would be correct. On the other hand, the date of the design and possible construction of this robot was 1495, a little more than five centuries ago. The key point in the title is the lack of a trademarked name, as Leonardo was the designer of this sophisticated system. His notes from the Codex Altanticus represent the foundation of this report. English translations of da Vinci's notebooks are currently available. Beginning in the 1950s, investigators at the University of California began to ponder the significance of some of da Vinci's markings on what appeared to be technical drawings. Such markings also occur in his Codex Atlanticus (the largest single collection of da Vinci's sheets, consisting of 1119 separate pages and 481 folios) along with a large number of other mechanical devices. Continuing research at the Instituto e Museo di Storia della Scienza in Florence has yielded a great deal of information about Leonardo's intentions with regard to his mechanical knight. It is now known that da Vinci's robot would have had the outer appearance of a Germanic knight. It had a complex core of mechanical devices that probably was human powered. The robot had two independent operating systems. The first had three degree-of-freedom legs, ankles, knees, and hips. The second had four degrees of freedom in the arms with articulated shoulders, elbows, wrists, and hands. A mechanical analog-programmable controller within the chest provided the power and control for the arms. The legs were powered by an external crank arrangement driving the cable, which connected to key locations near each lower extremity's joints. Da Vinci also is known to have devised a programmable front-wheel-drive automobile with rack-and-pinion suspension mechanisms at age 26. He would recall this device again, when, at age 40, he is thought to have built a programmable automated

Life history tactics shape amphibians' demographic responses to the North Atlantic Oscillation.

PubMed

Cayuela, Hugo; Joly, Pierre; Schmidt, Benedikt R; Pichenot, Julian; Bonnaire, Eric; Priol, Pauline; Peyronel, Olivier; Laville, Mathias; Besnard, Aurélien

2017-11-01

Over the last three decades, climate abnormalities have been reported to be involved in biodiversity decline by affecting population dynamics. A growing number of studies have shown that the North Atlantic Oscillation (NAO) influences the demographic parameters of a wide range of plant and animal taxa in different ways. Life history theory could help to understand these different demographic responses to the NAO. Indeed, theory states that the impact of weather variation on a species' demographic traits should depend on its position along the fast-slow continuum. In particular, it is expected that NAO would have a higher impact on recruitment than on adult survival in slow species, while the opposite pattern is expected occur in fast species. To test these predictions, we used long-term capture-recapture datasets (more than 15,000 individuals marked from 1965 to 2015) on different surveyed populations of three amphibian species in Western Europe: Triturus cristatus, Bombina variegata, and Salamandra salamandra. Despite substantial intraspecific variation, our study revealed that these three species differ in their position on a slow-fast gradient of pace of life. Our results also suggest that the differences in life history tactics influence amphibian responses to NAO fluctuations: Adult survival was most affected by the NAO in the species with the fastest pace of life (T. cristatus), whereas recruitment was most impacted in species with a slower pace of life (B. variegata and S. salamandra). In the context of climate change, our findings suggest that the capacity of organisms to deal with future changes in NAO values could be closely linked to their position on the fast-slow continuum. © 2017 John Wiley & Sons Ltd.

Impacts of radiation management techniques on the North Atlantic Oscillation

NASA Astrophysics Data System (ADS)

Adakudlu, Muralidhar; Helge Otterå, Odd; Tjiputra, Jerry; Muri, Helene; Grini, Alf; Schulz, Michael

2017-04-01

The effectiveness of various climate engineering techniques in limiting the global warming signal to reasonable levels has been the topic of state-of-the-art research on climate change. Using an Earth system model, we show that these techniques have the potential to bring down the high CO2 concentration climate in RCP8.5 to a moderate climate similar to RCP4.5 in terms of global temperature. Nevertheless, their influence on the regional aspects of atmospheric circulation is not clear. The regional circulation patterns in the atmosphere are largely characterized by the natural variability modes, such as the North Atlantic Oscillation (NAO). In this study, we assess the impacts of three radiation managment techniques, namely, Stratospheric Aerosol Injection (SAI), Marine Sky Brightening (MSB) and Cirrus Cloud Thinning (CCT), on the structure and features of the NAO. The results indicate an east-northeastward shift as well as intensification of the NAO spatial pattern in the global warming scenarios of RCP4.5 and RCP8.5, with the signal being most intense in the latter. The climate engineering forcings when applied to the RCP8.5 case tend to reduce the strength of the NAO with little impact on its position. The CCT case appears to have the maximum effect on the NAO signal. The patterns of cloud radiative forcing, expressed as the difference between net radiative forcing at TOA under average conditions and clear sky conditions, reveal a northeastward shift of the radiative heating in the north Atlantic region. This implies a possible link between the changes in the NAO signal and the cloud radiative forcing.

PKC phosphorylates residues in the N-terminal of the DA transporter to regulate amphetamine-induced DA efflux.

PubMed

Wang, Qiang; Bubula, Nancy; Brown, Jason; Wang, Yunliang; Kondev, Veronika; Vezina, Paul

2016-05-27

The DA transporter (DAT), a phosphoprotein, controls extracellular dopamine (DA) levels in the central nervous system through transport or reverse transport (efflux). Multiple lines of evidence support the claim that PKC significantly contributes to amphetamine-induced DA efflux. Other signaling pathways, involving CaMKII and ERK, have also been shown to regulate DAT mediated efflux. Here we assessed the contribution of putative PKC residues (S4, S7, S13) in the N-terminal of the DAT to amphetamine-induced DA efflux by transfecting DATs containing different serine to alanine (S-A) point mutations into DA pre-loaded HEK-293 cells and incubating these cells in amphetamine (2μM). The effects of a S-A mutation at the non-PKC residue S12 and a threonine to alanine (T-A) mutation at the ERK T53 residue were also assessed for comparison. WT-DATs were used as controls. In an initial experiment, we confirmed that inhibiting PKC with Go6976 (130nM) significantly reduced amphetamine-induced DA efflux. In subsequent experiments, cells transfected with the S4A, S12A, S13A, T53A and S4,7,13A mutants showed a reduction in amphetamine-induced DA efflux similar to that observed with Go6976. Interestingly, cells transfected with the S7A mutant, identified by some as a PKC-PKA residue, showed unperturbed WT-DAT levels of amphetamine-induced DA efflux. These results indicate that phosphorylation by PKC of select residues in the DAT N-terminal can regulate amphetamine-induced efflux. PKC can act either independently or in concert with other kinases such as ERK to produce this effect. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Study of hydrogen in phthalocyanine semiconductors using muSR technique =

NASA Astrophysics Data System (ADS)

Duarte, Joao Pedro Piroto Pereira

Este trabalho apresenta um estudo experimental dos semicondutores organicos Ftalocianina (H2Pc), Ftalocianina de Zinco (ZnPc) e Ftalocianina de Cobre (CuPc) por tecnicas de µSR, tendo-se obtido informacao detalhada sobre a estrutura electronica dos estados de carga formados pelo muao positivo nos tres compostos, e sobre as interaccoes dinamicas a que esses estados se encontram sujeitos. Os resultados do estudo indicam que nas ftalocianias com caracter nao magneticas H2Pc e ZnPc se da a formacao de tres radicais muonicos paramagneticos distintos. A estrutura hiperfina destes radicais, referidos como estados I, II e III, foi caracterizada atraves da medida dos parametros de acoplamento hipefino em conjunto com a parameterizacao da sua dependencia com a temperatura. Uma quarta componente paramagnetica do sinal µSR foi tambem identificada, mas sobre a qual nao foi possivel retirar conclusoes definitivas quanto a sua origem. Verificou-se que os parametros de acoplamento hiperfino isotropicos dos tres estados identificados se encontram numa regiao de valores entre os 100 e os 150MHz para os estados I e II, enquanto que para o estado III esta quantidade toma valores em torno de 10 MHz. A estrutura electronica de todos os estados possui simetria axial, caracterizada por parametros dipolares de cerca de 15MHz para os estados I e II, e 20MHz para o estado III. A origem dos estados I e II foi determinada como sendo devida a adicao de muonio a uma das ligacoes duplas existentes nos aneis benzenicos da periferia das moleculas de ftalocianina recorrendo a calculos de estrutura electronica, tendo-se verificado a existencia de um acoplamento entre a interaccao hiperfina desses estados e modos vibracionais desses aneis. A problematica da localizacao do estado III tambem foi abordada, tomando-se como hipotese mais provavel uma posicao intersticial entre duas moleculas de ftalocianina. O estudo das interaccoes dinamicas de spin destes tres estados revelou que o estado III esta

North Atlantic sub-decadal variability in climate models

NASA Astrophysics Data System (ADS)

Reintges, Annika; Martin, Thomas; Latif, Mojib; Park, Wonsun

2017-04-01

The North Atlantic Oscillation (NAO) is the dominant variability mode for the winter climate of the North Atlantic sector. During a positive (negative) NAO phase, the sea level pressure (SLP) difference between the subtropical Azores high and the subpolar Icelandic low is anomalously strong (weak). This affects, for example, temperature, precipitation, wind, and surface heat flux over the North Atlantic, and over large parts of Europe. In observations we find enhanced sub-decadal variability of the NAO index that goes along with a dipolar sea surface temperature (SST) pattern. The corresponding SLP and SST patterns are reproduced in a control experiment of the Kiel Climate Model (KCM). Large-scale air-sea interaction is suggested to be essential for the North Atlantic sub-decadal variability in the KCM. The Atlantic Meridional Overturning Circulation (AMOC) plays a key role, setting the timescale of the variability by providing a delayed negative feedback to the NAO. The interplay of the NAO and the AMOC on the sub-decadal timescale is further investigated in the CMIP5 model ensemble. For example, the average CMIP5 model AMOC pattern associated with sub-decadal variability is characterized by a deep-reaching dipolar structure, similar to the KCM's sub-decadal AMOC variability pattern. The results suggest that dynamical air-sea interactions are crucial to generate enhanced sub-decadal variability in the North Atlantic climate.

Temperature-precipitation relationship of the Common Era in northern Europe

NASA Astrophysics Data System (ADS)

Luoto, Tomi P.; Nevalainen, Liisa

2018-05-01

Due to the lack of knowledge on dynamics of the North Atlantic Oscillation (NAO) prior to the last millennium, synchronized records of air temperature and precipitation variability are needed to understand large-scale drivers of the hydroclimate. Here, we use completely synchronized paleolimnological proxy-based records of air temperature and effective precipitation from two Scandinavian lakes with ˜2000-year sediment profiles. We show that the relationship between air temperature and precipitation (T/P ratio) is synchronous in both study sites throughout the records suggesting warm and dry conditions at ˜300-1100 CE and cold and wet conditions at ˜1200-1900 CE. Owing to the significantly increased air temperatures, the most recent T/P ratio has again turned positive. During the first millennium of the Common Era, the T/P mimics patterns in Southern Oscillation index, whereas the second millennium shows response to the NAO index but is also concurrent with solar irradiance shifts. Since our T/P reconstruction is mostly linked with the NAO, we propose the T/P ratio as an indicator of the NAO. Our results from the coherent records provide first-time knowledge on the long-term temperature-precipitation relationship in Northern Europe that increase understanding of the comprehensive hydroclimate system in the region and the NAO dynamics also further back in time.

32 CFR 516.25 - DA Form 4.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 3 2010-07-01 2010-07-01 true DA Form 4. 516.25 Section 516.25 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY AID OF CIVIL AUTHORITIES AND PUBLIC RELATIONS LITIGATION Reporting Legal Proceedings to HQDA § 516.25 DA Form 4. (a) General. The DA Form 4 (See figure C-2...

Beyond Donor-Acceptor (D-A) Approach: Structure-Optoelectronic Properties-Organic Photovoltaic Performance Correlation in New D-A1 -D-A2 Low-Bandgap Conjugated Polymers.

PubMed

Chochos, Christos L; Drakopoulou, Sofia; Katsouras, Athanasios; Squeo, Benedetta M; Sprau, Christian; Colsmann, Alexander; Gregoriou, Vasilis G; Cando, Alex-Palma; Allard, Sybille; Scherf, Ullrich; Gasparini, Nicola; Kazerouni, Negar; Ameri, Tayebeh; Brabec, Christoph J; Avgeropoulos, Apostolos

2017-04-01

Low-bandgap near-infrared polymers are usually synthesized using the common donor-acceptor (D-A) approach. However, recently polymer chemists are introducing more complex chemical concepts for better fine tuning of their optoelectronic properties. Usually these studies are limited to one or two polymer examples in each case study so far, though. In this study, the dependence of optoelectronic and macroscopic (device performance) properties in a series of six new D-A 1 -D-A 2 low bandgap semiconducting polymers is reported for the first time. Correlation between the chemical structure of single-component polymer films and their optoelectronic properties has been achieved in terms of absorption maxima, optical bandgap, ionization potential, and electron affinity. Preliminary organic photovoltaic results based on blends of the D-A 1 -D-A 2 polymers as the electron donor mixed with the fullerene derivative [6,6]-phenyl-C 71 -butyric acid methyl ester demonstrate power conversion efficiencies close to 4% with short-circuit current densities (J sc ) of around 11 mA cm -2 , high fill factors up to 0.70, and high open-circuit voltages (V oc s) of 0.70 V. All the devices are fabricated in an inverted architecture with the photoactive layer processed in air with doctor blade technique, showing the compatibility with roll-to-roll large-scale manufacturing processes. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

The Ubiquitin Receptor DA1 Interacts with the E3 Ubiquitin Ligase DA2 to Regulate Seed and Organ Size in Arabidopsis[C][W

PubMed Central

Xia, Tian; Li, Na; Dumenil, Jack; Li, Jie; Kamenski, Andrei; Bevan, Michael W.; Gao, Fan; Li, Yunhai

2013-01-01

Seed size in higher plants is determined by the coordinated growth of the embryo, endosperm, and maternal tissue. Several factors that act maternally to regulate seed size have been identified, such as AUXIN RESPONSE FACTOR2, APETALA2, KLUH, and DA1, but the genetic and molecular mechanisms of these factors in seed size control are almost totally unknown. We previously demonstrated that the ubiquitin receptor DA1 acts synergistically with the E3 ubiquitin ligase ENHANCER1 OF DA1 (EOD1)/BIG BROTHER to regulate the final size of seeds in Arabidopsis thaliana. Here, we describe another RING-type protein with E3 ubiquitin ligase activity, encoded by DA2, which regulates seed size by restricting cell proliferation in the maternal integuments of developing seeds. The da2-1 mutant forms large seeds, while overexpression of DA2 decreases seed size of wild-type plants. Overexpression of rice (Oryza sativa) GRAIN WIDTH AND WEIGHT2, a homolog of DA2, restricts seed growth in Arabidopsis. Genetic analyses show that DA2 functions synergistically with DA1 to regulate seed size, but does so independently of EOD1. Further results reveal that DA2 interacts physically with DA1 in vitro and in vivo. Therefore, our findings define the genetic and molecular mechanisms of three ubiquitin-related proteins DA1, DA2, and EOD1 in seed size control and indicate that they are promising targets for crop improvement. PMID:24045020

Signatures of large-scale and local climates on the demography of white-tailed ptarmigan in Rocky Mountain National Park, Colorado, USA.

PubMed

Wang, Guiming; Hobbs, N Thompson; Galbraith, Hector; Giesen, Kenneth M

2002-09-01

Global climate change may impact wildlife populations by affecting local weather patterns, which, in turn, can impact a variety of ecological processes. However, it is not clear that local variations in ecological processes can be explained by large-scale patterns of climate. The North Atlantic oscillation (NAO) is a large-scale climate phenomenon that has been shown to influence the population dynamics of some animals. Although effects of the NAO on vertebrate population dynamics have been studied, it remains uncertain whether it broadly predicts the impact of weather on species. We examined the ability of local weather data and the NAO to explain the annual variation in population dynamics of white-tailed ptarmigan ( Lagopus leucurus) in Rocky Mountain National Park, USA. We performed canonical correlation analysis on the demographic subspace of ptarmigan and local-climate subspace defined by the empirical orthogonal function (EOF) using data from 1975 to 1999. We found that two subspaces were significantly correlated on the first canonical variable. The Pearson correlation coefficient of the first EOF values of the demographic and local-climate subspaces was significant. The population density and the first EOF of local-climate subspace influenced the ptarmigan population with 1-year lags in the Gompertz model. However, the NAO index was neither related to the first two EOF of local-climate subspace nor to the first EOF of the demographic subspace of ptarmigan. Moreover, the NAO index was not a significant term in the Gompertz model for the ptarmigan population. Therefore, local climate had stronger signature on the demography of ptarmigan than did a large-scale index, i.e., the NAO index. We conclude that local responses of wildlife populations to changing climate may not be adequately explained by models that project large-scale climatic patterns.

Winter precipitation changes during the Medieval Climate Anomaly and the Little Ice Age in arid Central Asia

NASA Astrophysics Data System (ADS)

Fohlmeister, Jens; Plessen, Birgit; Dudashvili, Alexey Sergeevich; Tjallingii, Rik; Wolff, Christian; Gafurov, Abror; Cheng, Hai

2017-12-01

The strength of the North Atlantic Oscillation (NAO) is considered to be the main driver of climate changes over the European and western Asian continents throughout the last millennium. For example, the predominantly warm Medieval Climate Anomaly (MCA) and the following cold period of the Little Ice Age (LIA) over Europe have been associated with long-lasting phases with a positive and negative NAO index. Its climatic imprint is especially pronounced in European winter seasons. However, little is known about the influence of NAO with respect to its eastern extent over the Eurasian continent. Here we present speleothem records (δ13C, δ18O and Sr/Ca) from the southern rim of Fergana Basin (Central Asia) revealing annually resolved past climate variations during the last millennium. The age control of the stalagmite relies on radiocarbon dating as large amounts of detrital material inhibit accurate 230Th dating. Present-day calcification of the stalagmite is most effective during spring when the cave atmosphere and elevated water supply by snow melting and high amount of spring precipitation provide optimal conditions. Seasonal precipitation variations cause changes of the stable isotope and Sr/Ca compositions. The simultaneous changes in these geochemical proxies, however, give also evidence for fractionation processes in the cave. By disentangling both processes, we demonstrate that the amount of winter precipitation during the MCA was generally higher than during the LIA, which is in line with climatic changes linked to the NAO index but opposite to the higher mountain records of Central Asia. Several events of strongly reduced winter precipitation are observed during the LIA in Central Asia. These dry winter events can be related to phases of a strong negative NAO index and all results reveal that winter precipitation over the central Eurasian continent is tightly linked to atmospheric NAO modes by the westerly wind systems.

The effects of climate change on harp seals (Pagophilus groenlandicus).

PubMed

Johnston, David W; Bowers, Matthew T; Friedlaender, Ari S; Lavigne, David M

2012-01-01

Harp seals (Pagophilus groenlandicus) have evolved life history strategies to exploit seasonal sea ice as a breeding platform. As such, individuals are prepared to deal with fluctuations in the quantity and quality of ice in their breeding areas. It remains unclear, however, how shifts in climate may affect seal populations. The present study assesses the effects of climate change on harp seals through three linked analyses. First, we tested the effects of short-term climate variability on young-of-the year harp seal mortality using a linear regression of sea ice cover in the Gulf of St. Lawrence against stranding rates of dead harp seals in the region during 1992 to 2010. A similar regression of stranding rates and North Atlantic Oscillation (NAO) index values was also conducted. These analyses revealed negative correlations between both ice cover and NAO conditions and seal mortality, indicating that lighter ice cover and lower NAO values result in higher mortality. A retrospective cross-correlation analysis of NAO conditions and sea ice cover from 1978 to 2011 revealed that NAO-related changes in sea ice may have contributed to the depletion of seals on the east coast of Canada during 1950 to 1972, and to their recovery during 1973 to 2000. This historical retrospective also reveals opposite links between neonatal mortality in harp seals in the Northeast Atlantic and NAO phase. Finally, an assessment of the long-term trends in sea ice cover in the breeding regions of harp seals across the entire North Atlantic during 1979 through 2011 using multiple linear regression models and mixed effects linear regression models revealed that sea ice cover in all harp seal breeding regions has been declining by as much as 6 percent per decade over the time series of available satellite data.

The Effects of Climate Change on Harp Seals (Pagophilus groenlandicus)

PubMed Central

Johnston, David W.; Bowers, Matthew T.; Friedlaender, Ari S.; Lavigne, David M.

2012-01-01

Harp seals (Pagophilus groenlandicus) have evolved life history strategies to exploit seasonal sea ice as a breeding platform. As such, individuals are prepared to deal with fluctuations in the quantity and quality of ice in their breeding areas. It remains unclear, however, how shifts in climate may affect seal populations. The present study assesses the effects of climate change on harp seals through three linked analyses. First, we tested the effects of short-term climate variability on young-of-the year harp seal mortality using a linear regression of sea ice cover in the Gulf of St. Lawrence against stranding rates of dead harp seals in the region during 1992 to 2010. A similar regression of stranding rates and North Atlantic Oscillation (NAO) index values was also conducted. These analyses revealed negative correlations between both ice cover and NAO conditions and seal mortality, indicating that lighter ice cover and lower NAO values result in higher mortality. A retrospective cross-correlation analysis of NAO conditions and sea ice cover from 1978 to 2011 revealed that NAO-related changes in sea ice may have contributed to the depletion of seals on the east coast of Canada during 1950 to 1972, and to their recovery during 1973 to 2000. This historical retrospective also reveals opposite links between neonatal mortality in harp seals in the Northeast Atlantic and NAO phase. Finally, an assessment of the long-term trends in sea ice cover in the breeding regions of harp seals across the entire North Atlantic during 1979 through 2011 using multiple linear regression models and mixed effects linear regression models revealed that sea ice cover in all harp seal breeding regions has been declining by as much as 6 percent per decade over the time series of available satellite data. PMID:22238591

North Atlantic Oscillation and moisture transport towards the Iberian Peninsula during winter

NASA Astrophysics Data System (ADS)

Ordóñez, Paulina; Liberato, Margarida L. R.; Gouveia, Célia; Trigo, Ricardo M.

2013-04-01

The North Atlantic Oscillation (NAO) is the major source of interannual variability in winter precipitation over the Iberian Peninsula (IP). Recent works have identified the most important sources of moisture that supply the IP during different seasons of the year, including the nearby western Mediterranean and the tropical-subtropical North Atlantic corridor that extends from the Gulf of Mexico to the IP, and the IP itself (Gimeno et al., 2010). However, although rainfall is directly related to the moisture supply, the relationship between the water vapor transported towards IP and the NAO phase remains unclear. In this work the moisture transport towards IP was analyzed using a Lagrangian diagnosis method, which relies on the Lagrangian particle dispersion model FLEXPART. This methodology computes budgets of evaporation minus precipitation (E-P) by evaluating changes in the specific humidity along back-trajectories. Here we have computed (for each day) the evolution of moisture of the particles bound for Iberia up to 10 days prior to their arrival. The analysis was constrained to the winter (DJF) season, responsible for the largest fraction of precipitation, for the 20 years of ECMWF Reanalyses ERA40 dataset from 1980 to 2000. The contribution of the NAO phase on the water budgets is examined using composites of the obtained (E - P) fields for the 5 most extreme positive and negative NAO years of the study period. Results confirm that the IP is dominated by positive (negative) E-P anomalies during positive (negative) NAO phase. Additionally an anomalous water vapor sink (source) region located approximately over the Gulf Stream is found during positive (negative) NAO phase. Gimeno L., Nieto R., Trigo R.M. , Vicente-Serrano S.M, Lopes-Moreno J.I., (2010) "Where does the Iberian Peninsula moisture come from? An answer based on a Lagrangian approach". J. Hydrometeorology, 11, 421-436 DOI: 10.1175/2009JHM1182.1.

The detailed chemistry and thermodynamics of sodium in oxygen-rich flames

NASA Technical Reports Server (NTRS)

Hynes, A. J.; Steinberg, M.; Schofield, K.

1982-01-01

Measurement of sodium and OH concentrations in ten oxygen-rich H2/O2/N2 flames by respective saturated and low-power laser induced fluorescence techniques have permitted a detailed examination of the pronounced flame chemistry of sodium in such oxygen rich media. Previous interpretations have been shown to be largely incomplete or in error. The flame downstream profiles indicate that the amount of free sodium tracks the decay of H-atom and as the flame radicals decay sodium becomes increasingly bound in a molecular form. A detailed kinetic model indicates that the sodium is distributed between NaOH and NaO2 species. Concentrations of NaO are very small and NaH negligible. The actual distribution is controlled by the state of equilibrium of the flames' basic free radicals. Na, NaO2 and NaOH are all coupled to one another by fast reactions which can rapidly interconvert one to another as flame conditions vary. Above about 2000K, NaOH becomes dominant whereas NaO2 plays an increasingly important contribution at lower temperatures.

Connections of Precipitable Water Vapor and Total Ozone Anomalies over European Russia with the North Atlantic Oscillation: Specific Features of Summer 2010

NASA Astrophysics Data System (ADS)

Sitnov, S. A.; Mokhov, I. I.; Bezverkhny, V. A.

2017-12-01

Based on the measurements of precipitable water vapor (PWV) and total column ozone (TCO) from the MODIS satellite instruments (Aqua/Terra platforms), the connections between the North Atlantic Oscillation (NAO) and the anomalies in PWV and TCO over European Russia (ER) in summer 2010 are analyzed. It is found that the PWV (TCO) anomalies over the northern ER in summer 2010 positively (negatively) correlated with the NAO, and the local correlations reached 0.68 (-0.55). The physical mechanisms of the correlations are discussed. A comparative analysis of the relationships between the NAO and the regional PWV and TCO anomalies over ER during the summer seasons of 2000-2015 is carried out.

Leonardo da Vinci and the Downburst.

NASA Astrophysics Data System (ADS)

Gedzelman, Stanley David

1990-05-01

Evidence from the drawings, experiments, and writings of Leonardo da Vinci are presented to demonstrate that da Vinci recognized and, possibly, discovered the downburst and understood its associated airflow. Other early references to vortex flows resembling downbursts are mentioned.

Test Review: TestDaF

ERIC Educational Resources Information Center

Norris, John; Drackert, Anastasia

2018-01-01

The Test of German as a Foreign Language (TestDaF) plays a critical role as a standardized test of German language proficiency. Developed and administered by the Society for Academic Study Preparation and Test Development (g.a.s.t.), TestDaF was launched in 2001 and has experienced persistent annual growth, with more than 44,000 test takers in…

Overview of ATLAS PanDA Workload Management

NASA Astrophysics Data System (ADS)

Maeno, T.; De, K.; Wenaus, T.; Nilsson, P.; Stewart, G. A.; Walker, R.; Stradling, A.; Caballero, J.; Potekhin, M.; Smith, D.; ATLAS Collaboration

2011-12-01

The Production and Distributed Analysis System (PanDA) plays a key role in the ATLAS distributed computing infrastructure. All ATLAS Monte-Carlo simulation and data reprocessing jobs pass through the PanDA system. We will describe how PanDA manages job execution on the grid using dynamic resource estimation and data replication together with intelligent brokerage in order to meet the scaling and automation requirements of ATLAS distributed computing. PanDA is also the primary ATLAS system for processing user and group analysis jobs, bringing further requirements for quick, flexible adaptation to the rapidly evolving analysis use cases of the early datataking phase, in addition to the high reliability, robustness and usability needed to provide efficient and transparent utilization of the grid for analysis users. We will describe how PanDA meets ATLAS requirements, the evolution of the system in light of operational experience, how the system has performed during the first LHC data-taking phase and plans for the future.

Overview of ATLAS PanDA Workload Management

DOE Office of Scientific and Technical Information (OSTI.GOV)

Maeno T.; De K.; Wenaus T.

2011-01-01

The Production and Distributed Analysis System (PanDA) plays a key role in the ATLAS distributed computing infrastructure. All ATLAS Monte-Carlo simulation and data reprocessing jobs pass through the PanDA system. We will describe how PanDA manages job execution on the grid using dynamic resource estimation and data replication together with intelligent brokerage in order to meet the scaling and automation requirements of ATLAS distributed computing. PanDA is also the primary ATLAS system for processing user and group analysis jobs, bringing further requirements for quick, flexible adaptation to the rapidly evolving analysis use cases of the early datataking phase, in additionmore » to the high reliability, robustness and usability needed to provide efficient and transparent utilization of the grid for analysis users. We will describe how PanDA meets ATLAS requirements, the evolution of the system in light of operational experience, how the system has performed during the first LHC data-taking phase and plans for the future.« less

Vi-da: vitiligo diagnostic assistance mobile application

NASA Astrophysics Data System (ADS)

Nugraha, G. A.; Nurhudatiana, A.; Bahana, R.

2018-03-01

Vitiligo is a skin disorder in which white patches of depigmentation appear on different parts of the body. Usually, patients come to hospitals or clinics to have their vitiligo conditions assessed. This can be very tiring to the patients, as vitiligo treatments usually take a relatively long period of time, which can range from months to years. To address this challenge, we present in this paper a prototype of an Android-based mobile application called Vi-DA, which stands for Vitiligo Diagnostic Assistance. Vi-DA consists of three subsystems, which are user sign-up subsystem, camera and image analysis subsystem, and progress report subsystem. The mobile application was developed in Java programming language and uses MySQL as the database system. Vi-DA adopts a vitiligo segmentation algorithm to segment input image into normal skin area, vitiligo skin area, and non-skin area. Results showed that Vi-DA gave comparable results to the previous system implemented in Matlab. User acceptance testing results also showed that all respondents agreed on the usefulness of the system and agreed to use Vi-DA again in the future. Vi-DA benefits both dermatologists and patients as not only a computer-aided diagnosis (CAD) tool but also as a smart application that can be used for self-assessment at home.

Ultrasonic location system =

NASA Astrophysics Data System (ADS)

Albuquerque, Daniel Filipe

Esta tese apresenta um sistema de localizacao baseado exclusivamente em ultrassons, nao necessitando de recorrer a qualquer outra tecnologia. Este sistema de localizacao foi concebido para poder operar em ambientes onde qualquer outra tecnologia nao pode ser utilizada ou o seu uso esta condicionado, como sao exemplo aplicacoes subaquaticas ou ambientes hospitalares. O sistema de localizacao proposto faz uso de uma rede de farois fixos permitindo que estacoes moveis se localizem. Devido a necessidade de transmissao de dados e medicao de distancias foi desenvolvido um pulso de ultrassons robusto a ecos que permite realizar ambas as tarefas com sucesso. O sistema de localizacao permite que as estacoes moveis se localizem escutando apenas a informacao em pulsos de ultrassons enviados pelos farois usando para tal um algoritmo baseado em diferencas de tempo de chegada. Desta forma a privacidade dos utilizadores e garantida e o sistema torna-se completamente independente do numero de utilizadores. Por forma a facilitar a implementacao da rede de farois apenas sera necessario determinar manualmente a posicao de alguns dos farois, designados por farois ancora. Estes irao permitir que os restantes farois, completamente autonomos, se possam localizar atraves de um algoritmo iterativo de localizacao baseado na minimizacao de uma funcao de custo. Para que este sistema possa funcionar como previsto sera necessario que os farois possam sincronizar os seus relogios e medir a distancia entre eles. Para tal, esta tese propoe um protocolo de sincronizacao de relogio que permite tambem obter as medidas de distancia entre os farois trocando somente tres mensagens de ultrassons. Adicionalmente, o sistema de localizacao permite que farois danificados possam ser substituidos sem comprometer a operabilidade da rede reduzindo a complexidade na manutencao. Para alem do mencionado, foi igualmente implementado um simulador de ultrassons para ambientes fechados, o qual provou ser bastante

Metaproteomics of Microbiota in Naturally Fermented Soybean Paste, Da-jiang.

PubMed

Zhang, Ping; Zhang, Pengfei; Xie, Mengxi; An, Feiyu; Qiu, Boshu; Wu, Rina

2018-05-01

Da-jiang is a typical traditional fermented soybean product in China. At present, the proteins in da-jiang are needed to be explored. The composition and species of microbial proteins in traditional fermented da-jiang were analyzed by metaproteomics based on sodium dodecyl sulfonate-polyacrylamide gel electrophoresis (SDS-PAGE) and liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). The results showed that the number and variety of microbial proteins in the traditional fermented da-jiang from different regions were different. The production site influences the fermentation in da-jiang. Then we analyzed the functions of the microbial proteins identified in da-jiang, and found that they were mainly involved in the process of protein synthesis, glycometabolism and nucleic acid synthesis. In addtion, we compared the proteins composition in different da-jiang. There are 51 common proteins of naturally fermented da-jiang, and 25 common microbial sources. The main commonly microbial sources of fungal proteins are Saccharomyces cerevisiae and Schizosaccharomyces; the main commonly microbial sources of bacterial proteins are Enterococcus faecalis, Leuconostoc mesenteroides, Acinetobacter baumannii, and Bacillus subtilis. These common microbes play the predominant role in da-jiang fermentation. The present results help us to understand the fermentation of da-jiang and improve the quality and safety of final products in the future. The study illustrated metaproteome of microbiota in traditional fermented soybean paste, da-jiang, by sodium dodecyl sulfonate-polyacrylamide gel electrophoresis (SDS-PAGE) and liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). A method of extracting metaproteome from microbiota in da-jiang was attempted. The findings help to understand the fermentation of da-jiang and improve the quality and safety of da-jiang in fermented industry. © 2018 Institute of Food Technologists®.

Long term variability of O3 in the UTLS as measured by MOZAIC since 1994 and its link to NAO indices

NASA Astrophysics Data System (ADS)

Thouret, Valérie; Cammas, Jean-Pierre; Cassou, Christophe; Nédélec, Philippe; Athier, Gilles; Boulanger, Damien; Karcher, Fernand

2010-05-01

The MOZAIC program (http://mozaic.aero.obs-mip.fr) measures O3 and thermodynamical parameters since August 1994 on board 5 commercial aircraft operated by European airlines. Thus, most of the sampling data have been recorded at northern mid-latitudes, between 9 and 12 km altitude, in the upper troposphere - lower stratosphere (UTLS). To better assess the O3 distribution and its seasonal and regional behavior, measurements have been referenced to the tropopause altitude. The tropopause is defined as being a transition zone 30 hPa thick centered on the surface PV=2 pvu. Two other layers are defined on either side of the tropopause to encompass all the cruise levels of the MOZAIC flights, as fully described in Thouret et al., (2006). Then, we have access to the upper tropospheric and lower stratospheric ozone distributions independently of any ozone threshold and regardless of the seasonal variations of the tropopause. We will present a climatology of O3 in the UTLS for different regions of the northern mid-latitudes, from Western US to Japan, via North Atlantic and Europe. We will focus on the seasonal and regional differences to better highlight the ozone behavior in this critical region. Given the availability of 15 years of data (up to 2008), we also aim to further assess the interannual variability and "trends". The first analysis presented in Thouret et al., (2006) showed an increase of O3 of about 1%/year between 1994 and 2003 in both the UT and the LS over a large North Atlantic area. This time period was actually characterized by the so-called (positive) anomaly 1998-1999. O3 time series and anomalies have been correlated with the atmospheric teleconnections indices (NAO and NAM), showing thus the coupling between the stratosphere and the troposphere and the role of the variations in large scale dynamics, through wave-driven stratospheric circulation influencing down to the middle and upper troposphere. Later on, Koumoutsaris et al., (2008) have also shown

Identification of entomopathogenic nematodes and symbiotic bacteria from Nam Nao National Park in Thailand and larvicidal activity of symbiotic bacteria against Aedes aegypti and Aedes albopictus

PubMed Central

Yooyangket, Temsiri; Muangpat, Paramaporn; Polseela, Raxsina; Tandhavanant, Sarunporn; Thanwisai, Aunchalee

2018-01-01

Entomopathogenic nematodes (EPNs) that are symbiotically associated with Xenorhabdus and Photorhabdus bacteria can kill target insects via direct infection and toxin action. There are limited reports identifying such organisms in the National Park of Thailand. Therefore, the objectives of this study were to identify EPNs and symbiotic bacteria from Nam Nao National Park, Phetchabun Province, Thailand and to evaluate the larvicidal activity of bacteria against Aedes aegypti and Ae. albopictus. A total of 12 EPN isolates belonging to Steinernema and Heterorhabditis were obtained form 940 soil samples between February 2014 and July 2016. EPNs were molecularly identified as S. websteri (10 isolates) and H. baujardi (2 isolates). Symbiotic bacteria were isolated from EPNs and molecularly identified as P. luminescens subsp. akhurstii (13 isolates), X. stockiae (11 isolates), X. vietnamensis (2 isolates) and X. japonica (1 isolate). For the bioassay, bacterial suspensions were evaluated for toxicity against third to early fourth instar larvae of Aedes spp. The larvae of both Aedes species were orally susceptible to symbiotic bacteria. The highest larval mortality of Ae. aegypti was 99% after exposure to X. stockiae (bNN112.3_TH) at 96 h, and the highest mortality of Ae. albopictus was 98% after exposure to P. luminescens subsp. akhurstii (bNN121.4_TH) at 96 h. In contrast to the control groups (Escherichia coli and distilled water), the mortality rate of both mosquito larvae ranged between 0 and 7% at 72 h. Here, we report the first observation of X. vietnamensis in Thailand. Additionally, we report the first observation of P. luminescens subsp. akhurstii associated with H. baujardi in Thailand. X. stockiae has potential to be a biocontrol agent for mosquitoes. This investigation provides a survey of the basic diversity of EPNs and symbiotic bacteria in the National Park of Thailand, and it is a bacterial resource for further studies of bioactive compounds. PMID:29641570

[Trattamento del disturbo da uso di alcol da un punto di vista psicologico].

PubMed

Coriale, Giovanna; Fiorentino, Daniela; De Rosa, Francesca; Solombrino, Simona; Scalese, Bruna; Ciccarelli, Rosaria; Attilia, Fabio; Vitali, Mario; Musetti, Alessia; Fiore, Marco; Ceccanti, Mauro

2018-01-01

RIASSUNTO. L'elaborazione del piano di trattamento rappresenta un momento molto delicato e complesso del processo terapeutico del disturbo da abuso di alcol (DUA). È la fase in cui le informazioni raccolte da un'équipe di professionisti (medici, psicologi e assistenti sociali) (modello bio-psico-sociale del DUA) vengono messe insieme per decidere il percorso terapeutico più adatto. Per quanto riguarda la parte psicologica, è di notevole importanza scegliere un trattamento clinico in grado di ridurre al minimo la mancata adesione al trattamento e, per i soggetti che rimangono in trattamento, di garantirne l'efficacia. Se da una parte, le tecniche psicoanalitiche e comportamentali hanno fornito le basi della terapia psicologica dell'alcolismo, dall'altra, gli approcci basati sull'evidenza scientifica sono stati elaborati a partire dai principi del colloquio motivazionale e della terapia cognitivo-comportamentale. In questo articolo viene fornita una panoramica dei trattamenti che sono risultati più efficaci nel trattare il DUA e delle modalità temporali più adeguate per monitorare l'efficacia del trattamento.

Evaluation of the Efficacy and Safety of DA-9601 versus Its New Formulation, DA-5204, in Patients with Gastritis: Phase III, Randomized, Double-Blind, Non-Inferiority Study.

PubMed

Choi, Yoon Jin; Lee, Dong Ho; Choi, Myung Gyu; Lee, Sung Joon; Kim, Sung Kook; Song, Geun Am; Rhee, Poong Lyul; Jung, Hwoon Yong; Kang, Dae Hwan; Lee, Yong Chan; Lee, Si Hyung; Choi, Suck Chei; Shim, Ki Nam; Seol, Sang Yong; Moon, Jeong Seop; Shin, Yong Woon; Kim, Hyun Soo; Lee, Soo Teik; Cho, Jin Woong; Choi, Eun Kwang; Lee, Oh Young; Jang, Jin Seok

2017-11-01

This study compared the efficacy of DA-9601 (Dong-A ST Co., Seoul, Korea) and its new formulation, DA-5204 (Dong-A ST Co.), for treating erosive gastritis. This phase III, randomized, multicenter, double-blind, non-inferiority trial randomly assigned 434 patients with endoscopically proven gastric mucosal erosions into two groups: DA-9601 3 times daily or DA-5,204 twice daily for 2 weeks. The final analysis included 421 patients (DA-5204, 209; DA-9601, 212). The primary endpoint (rate of effective gastric erosion healing) and secondary endpoints (cure rate of endoscopic erosion and gastrointestinal [GI] symptom relief) were assessed using endoscopy after the treatment. Drug-related adverse events (AEs), including GI symptoms, were also compared. At week 2, gastric healing rates with DA-5204 and DA-9601 were 42.1% (88/209) and 42.5% (90/212), respectively. The difference between the groups was -0.4% (95% confidence interval, -9.8% to 9.1%), which was above the non-inferiority margin of -14%. The cure rate of gastric erosion in both groups was 37.3%. The improvement rates of GI symptoms with DA-5204 and DA-9601 were 40.4% and 40.8%, respectively. There were no statistically significant differences between the two groups in both secondary endpoints. AEs were reported in 18 (8.4%) patients in the DA-5204 group and 19 (8.8%) in the DA-9601 group. Rates of AE were not different between the two groups. No serious AE or adverse drug reaction (ADR) occurred. These results demonstrate the non-inferiority of DA-5204 compared to DA-9601. DA-5204 is as effective as DA-9601 in the treatment of erosive gastritis. Registered randomized clinical trial at ClinicalTrials.gov (NCT02282670). © 2017 The Korean Academy of Medical Sciences.

Concentrated Electrolyte for the Sodium-Oxygen Battery: Solvation Structure and Improved Cycle Life.

PubMed

He, Mingfu; Lau, Kah Chun; Ren, Xiaodi; Xiao, Neng; McCulloch, William D; Curtiss, Larry A; Wu, Yiying

2016-12-05

Alkali metal-oxygen batteries are of great interests for energy storage because of their unparalleled theoretical energy densities. Particularly attractive is the emerging Na-O 2 battery because of the formation of superoxide as the discharge product. Dimethyl sulfoxide (DMSO) is a promising solvent for this battery but its instability towards Na makes it impractical in the Na-O 2 battery. Herein we report the enhanced stability of Na in DMSO solutions containing concentrated sodium trifluoromethanesulfonimide (NaTFSI) salts (>3 mol kg -1 ). Raman spectra of NaTFSI/DMSO electrolytes and ab initio molecular dynamics simulation reveal the Na + solvation number in DMSO and the formation of Na(DMSO) 3 (TFSI)-like solvation structure. The majority of DMSO molecules solvating Na + in concentrated solutions reduces the available free DMSO molecules that can react with Na and renders the TFSI anion decomposition, which protects Na from reacting with the electrolyte. Using these concentrated electrolytes, Na-O 2 batteries can be cycled forming sodium superoxide (NaO 2 ) as the sole discharge product with improved long cycle life, highlighting the beneficial role of concentrated electrolytes for Na-based batteries. © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Concentrated Electrolyte for the Sodium-Oxygen Battery: Solvation Structure and Improved Cycle Life

DOE PAGES

He, Mingfu; Lau, Kah Chun; Ren, Xiaodi; ...

2016-11-03

Alkali metal-oxygen batteries are of great interests for energy storage because of their unparalleled theoretical energy densities. Particularly attractive is the emerging Na-O 2 battery because of the formation of superoxide as the discharge product. Dimethyl sulfoxide (DMSO) is a promising solvent for this battery but its instability towards Na makes it impractical in the Na-O 2 battery. Here in this paper, we report the enhanced stability of Na in DMSO solutions containing concentrated sodium trifluoromethanesulfonimide (NaTFSI) salts (>3molkg -1). Raman spectra of NaTFSI/DMSO electrolytes and abinitio molecular dynamics simulation reveal the Na + solvation number in DMSO and themore » formation of Na(DMSO) 3(TFSI)-like solvation structure. The majority of DMSO molecules solvating Na + in concentrated solutions reduces the available free DMSO molecules that can react with Na and renders the TFSI anion decomposition, which protects Na from reacting with the electrolyte. Using these concentrated electrolytes, Na-O 2 batteries can be cycled forming sodium superoxide (NaO 2) as the sole discharge product with improved long cycle life, highlighting the beneficial role of concentrated electrolytes for Na-based batteries.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

He, Mingfu; Lau, Kah Chun; Ren, Xiaodi

Alkali metal-oxygen batteries are of great interests for energy storage because of their unparalleled theoretical energy densities. Particularly attractive is the emerging Na-O 2 battery because of the formation of superoxide as the discharge product. Dimethyl sulfoxide (DMSO) is a promising solvent for this battery but its instability towards Na makes it impractical in the Na-O 2 battery. Here in this paper, we report the enhanced stability of Na in DMSO solutions containing concentrated sodium trifluoromethanesulfonimide (NaTFSI) salts (>3molkg -1). Raman spectra of NaTFSI/DMSO electrolytes and abinitio molecular dynamics simulation reveal the Na + solvation number in DMSO and themore » formation of Na(DMSO) 3(TFSI)-like solvation structure. The majority of DMSO molecules solvating Na + in concentrated solutions reduces the available free DMSO molecules that can react with Na and renders the TFSI anion decomposition, which protects Na from reacting with the electrolyte. Using these concentrated electrolytes, Na-O 2 batteries can be cycled forming sodium superoxide (NaO 2) as the sole discharge product with improved long cycle life, highlighting the beneficial role of concentrated electrolytes for Na-based batteries.« less

VerSeDa: vertebrate secretome database

PubMed Central

Cortazar, Ana R.; Oguiza, José A.

2017-01-01

Based on the current tools, de novo secretome (full set of proteins secreted by an organism) prediction is a time consuming bioinformatic task that requires a multifactorial analysis in order to obtain reliable in silico predictions. Hence, to accelerate this process and offer researchers a reliable repository where secretome information can be obtained for vertebrates and model organisms, we have developed VerSeDa (Vertebrate Secretome Database). This freely available database stores information about proteins that are predicted to be secreted through the classical and non-classical mechanisms, for the wide range of vertebrate species deposited at the NCBI, UCSC and ENSEMBL sites. To our knowledge, VerSeDa is the only state-of-the-art database designed to store secretome data from multiple vertebrate genomes, thus, saving an important amount of time spent in the prediction of protein features that can be retrieved from this repository directly. Database URL: VerSeDa is freely available at http://genomics.cicbiogune.es/VerSeDa/index.php PMID:28365718

VerSeDa: vertebrate secretome database.

PubMed

Cortazar, Ana R; Oguiza, José A; Aransay, Ana M; Lavín, José L

2017-01-01

Based on the current tools, de novo secretome (full set of proteins secreted by an organism) prediction is a time consuming bioinformatic task that requires a multifactorial analysis in order to obtain reliable in silico predictions. Hence, to accelerate this process and offer researchers a reliable repository where secretome information can be obtained for vertebrates and model organisms, we have developed VerSeDa (Vertebrate Secretome Database). This freely available database stores information about proteins that are predicted to be secreted through the classical and non-classical mechanisms, for the wide range of vertebrate species deposited at the NCBI, UCSC and ENSEMBL sites. To our knowledge, VerSeDa is the only state-of-the-art database designed to store secretome data from multiple vertebrate genomes, thus, saving an important amount of time spent in the prediction of protein features that can be retrieved from this repository directly. VerSeDa is freely available at http://genomics.cicbiogune.es/VerSeDa/index.php. © The Author(s) 2017. Published by Oxford University Press.

Evaluation of thermochemical biomass conversion in fluidized bed =

NASA Astrophysics Data System (ADS)

Neves, Daniel dos Santos Felix das

Dado o aumento acelerado dos precos dos combustiveis fosseis e as incertezas quanto a sua disponibilidade futura, tem surgido um novo interesse nas tecnologias da biomassa aplicadas a producao de calor, eletricidade ou combustiveis sinteticos. Nao obstante, para a conversao termoquimica de uma particula de biomassa solida concorrem fenomenos bastante complexos que levam, em primeiro lugar, a secagem do combustivel, depois a pirolise e finalmente a combustao ou gasificacao propriamente ditas. Uma descricao relativamente incompleta de alguns desses estagios de conversao constitui ainda um obstaculo ao desenvolvimento das tecnologias que importa ultrapassar. Em particular, a presenca de elevados conteudos de materia volatil na biomassa poe em evidencia o interesse pratico do estudo da pirolise. A importância da pirolise durante a combustao de biomassa foi evidenciada neste trabalho atraves de ensaios realizados num reator piloto de leito fluidizado borbulhante. Verificou-se que o processo ocorre em grande parte a superficie do leito com chamas de difusao devido a libertacao de volateis, o que dificulta o controlo da temperatura do reator acima do leito. No caso da gasificacao de biomassa a pirolise pode inclusivamente determinar a eficiencia quimica do processo. Isso foi mostrado neste trabalho durante ensaios de gasificacao num reator de leito fluidizado de 2MWth, onde um novo metodo de medicao permitiu fechar o balanco de massa ao gasificador e monitorizar o grau de conversao da biomassa. A partir destes resultados tornou-se clara a necessidade de descrever adequadamente a pirolise de biomassa com vista ao projeto e controlo dos processos. Em aplicacoes de engenharia ha particular interesse na estequiometria e propriedades dos principais produtos piroliticos. Neste trabalho procurou-se responder a esta necessidade, inicialmente atraves da estruturacao de dados bibliograficos sobre rendimentos de carbonizado, liquidos piroliticos e gases, assim como composicoes

Intraseasonal interaction between the Madden-Julian Oscillation and the North Atlantic Oscillation.

PubMed

Cassou, Christophe

2008-09-25

Bridging the traditional gap between the spatio-temporal scales of weather and climate is a significant challenge facing the atmospheric community. In particular, progress in both medium-range and seasonal-to-interannual climate prediction relies on our understanding of recurrent weather patterns and the identification of specific causes responsible for their favoured occurrence, persistence or transition. Within this framework, I here present evidence that the main climate intra-seasonal oscillation in the tropics-the Madden-Julian Oscillation (MJO)-controls part of the distribution and sequences of the four daily weather regimes defined over the North Atlantic-European region in winter. North Atlantic Oscillation (NAO) regimes are the most affected, allowing for medium-range predictability of their phase far exceeding the limit of around one week that is usually quoted. The tropical-extratropical lagged relationship is asymmetrical. Positive NAO events mostly respond to a mid-latitude low-frequency wave train initiated by the MJO in the western-central tropical Pacific and propagating eastwards. Precursors for negative NAO events are found in the eastern tropical Pacific-western Atlantic, leading to changes along the North Atlantic storm track. Wave-breaking diagnostics tend to support the MJO preconditioning and the role of transient eddies in setting the phase of the NAO. I present a simple statistical model to quantitatively assess the potential predictability of the daily NAO index or the sign of the NAO regimes when they occur. Forecasts are successful in approximately 70 per cent of the cases based on the knowledge of the previous approximately 12-day MJO phase used as a predictor. This promising skill could be of importance considering the tight link between weather regimes and both mean conditions and the chances of extreme events occurring over Europe. These findings are useful for further stressing the need to better simulate and forecast the tropical

Virtual Surgery for the Nasal Airway: A Preliminary Report on Decision Support and Technology Acceptance.

PubMed

Vanhille, Derek L; Garcia, Guilherme J M; Asan, Onur; Borojeni, Azadeh A T; Frank-Ito, Dennis O; Kimbell, Julia S; Pawar, Sachin S; Rhee, John S

2018-01-01

Nasal airway obstruction (NAO) is a common problem that affects patient quality of life. Surgical success for NAO correction is variable. Virtual surgery planning via computational fluid dynamics (CFD) has the potential to improve the success rates of NAO surgery. To elicit surgeon feedback of a virtual surgery planning tool for NAO and to determine if this tool affects surgeon decision making. For this cross-sectional study, 60-minute face-to-face interviews with board-certified otolaryngologists were conducted at a single academic otolaryngology department from September 16, 2016, through October 7, 2016. Virtual surgery methods were introduced, and surgeons were able to interact with the virtual surgery planning tool interface. Surgeons were provided with a patient case of NAO, and open feedback of the platform was obtained, with emphasis on surgical decision making. Likert scale responses and qualitative feedback were collected for the virtual surgery planning tool and its influence on surgeon decision making. Our 9 study participants were all male, board-certified otolaryngologists with a mean (range) 15 (4-28) number of years in practice and a mean (range) number of nasal surgeries per month at 2.2 (0.0-6.0). When examined on a scale of 1 (not at all) to 5 (completely), surgeon mean (SD) score was 3.4 (0.5) for how realistic the virtual models were compared with actual surgery. On the same scale, when asked how much the virtual surgery planning tool changed surgeon decision making, mean (SD) score was 2.6 (1.6). On a scale of 1 (strongly disagree) to 7 (strongly agree), surgeon scores for perceived usefulness of the technology and attitude toward using it were 5.1 (1.1) and 5.7 (0.9), respectively. Our study shows positive surgeon experience with a virtual surgery planning tool for NAO based on CFD simulations. Surgeons felt that future applications and areas of study of the virtual surgery planning tool include its potential role for patient counseling

North Atlantic Oscillation and pollutants variability in Europe: model analysis and measurements intercomparison

NASA Astrophysics Data System (ADS)

Pausata, F.; Pozzoli, L.; Van Dingenen, R.; Vignati, E.; Cavalli, F.; Dentener, F. J.

2013-12-01

Ozone pollution and particulate matter (PM) represent a serious health and environmental problem. While ozone pollution is mostly produced by photochemistry in summer, PM is of main concern during winter. Both pollutants can be influenced nt only by local scale processes but also by long range transport driven by the atmospheric circulation and stratospheric ozone intrusions. We analyze the role of large scale atmospheric circulation variability in the North Atlantic basin in determining surface ozone and PM concentrations over Europe. Here, we show, using ground station measurements and a coupled atmosphere-chemistry model simulation for the period 1980-2005, that with regard to ozone the North Atlantic Oscillation (NAO) does affect surface ozone concentrations - on a monthly timescale, over 10 ppbv in southwestern, central and northern Europe - during all seasons except fall. We find that the first Principal Component, computed from the time variation of the sea level pressure (SLP) field, detects the atmosphere circulation/ozone relationship not only in winter and spring but also during summer, when the atmospheric circulation weakens and regional photochemical processes peak. Given the NAO forecasting skill at intraseasonal time scale, the first Principal Component of the SLP field could be used as an indicator to identify areas more exposed to forthcoming ozone pollution events. Finally, our results suggest that the increasing baseline ozone in western and northern Europe during the 1990s could be related to the prevailing positive phase of the NAO in that period. With regard to PM, our study shows that in winter the NAO modulates surface PM concentrations accounting in average up to 30% of the total PM variability. During positive NAO phases, positive PM anomalies occur over southern Europe, and negative anomalies in central-northern Europe. A positve shift of the NAO mean states, hence, leads to an increase in cardiac and resipratory morbidity related to PM

The Caspian Sea Catchment influenced by Atlantic Teleconnections in CESM1.2.2 and Observations

NASA Astrophysics Data System (ADS)

Nandini, S. D.; Prange, M.; Schulz, M.

2017-12-01

The Caspian Sea (CS) is the world's largest inland sea and located within a closed (endorheic) drainage basin [ 37°-47N, 47°-54°E]. It has undergone dynamic variations (>3 m) during the past century with huge impacts on the economy, ecosystem and livelihood of coastal people. The origin of these variations as well as future changes are disputable. Here, we examine the impact of the major seasonal North Atlantic teleconnection patterns, the North Atlantic Oscillation (NAO) and the East Atlantic pattern (EA) on Caspian hydroclimate variability from 1850-2100 CE. Five Numerical experiments at different atmospheric grid resolutions (2° and 1°) and atmospheric model versions (CAM4 and CAM5) are carried out with the coupled Community Earth System Model (CESM1.2.2). Results reveal the 1° CESM1.2.2 CAM5 captures DJF NAO (46.5%) and EA (13.4%), agreeing well with observational data (1850-2000). The DJF NAO has a strong influence on the DJF temperature, rainfall and evaporation minus precipitation (E-P) over the Caspian sub-basins (Volga, Ural, Terek and Kura). Furthermore, 1° model climate projections (2020-2100 CE) are performed with different Representative Concentration Pathways (RCP4.5 and RCP8.5) to examine likely changes in the NAO and EA and their influence on the Caspian catchment. The NAO under the RCP4.5 and RCP8.5 scenarios remains the leading mode with the highest variance and influences E-P with increased precipitation over the Volga basin and increased evaporation over the Caspian Sea. The above canceling effects act on the hydroclimate variability in the Caspian sub-basins. Moreover, it is indicated that no substantial change is predicted in the CSL by the year 2100. Keywords: North Atlantic Oscillation (NAO), CESM1.2.2 resolutions, Evaporation minus Precipitation (E-P), RCP4.5, RCP8.5

Links between large-scale circulation patterns and streamflow in Central Europe: A review

NASA Astrophysics Data System (ADS)

Steirou, Eva; Gerlitz, Lars; Apel, Heiko; Merz, Bruno

2017-06-01

We disentangle the relationships between streamflow and large-scale atmospheric circulation in Central Europe (CE), an area affected by climatic influences from different origins (Atlantic, Mediterranean and Continental) and characterized by diverse topography and flow regimes. Our literature review examines in detail the links between mean, high and low flows in CE and large-scale circulation patterns, with focus on two closely related phenomena, the North Atlantic Oscillation (NAO) and the Western-zonal circulation (WC). For both patterns, significant relations, consistent between different studies, are found for large parts of CE. The strongest links are found for the winter season, forming a dipole-like pattern with positive relationships with streamflow north of the Alps and the Carpathians for both indices and negative relationships for the NAO in the south. An influence of winter NAO is also detected in the amplitude and timing of snowmelt flows later in the year. Discharge in CE has further been linked to other large-scale climatic modes such as the Scandinavia pattern (SCA), the East Atlantic/West Russian pattern (EA/WR), the El Niño-Southern Oscillation (ENSO) and synoptic weather patterns such as the Vb weather regime. Different mechanisms suggested in the literature to modulate links between streamflow and the NAO are combined with topographical characteristics of the target area in order to explain the divergent NAO/WC influence on streamflow in different parts of CE. In particular, a precipitation mechanism seems to regulate winter flows in North-Western Germany, an area with short duration of snow cover and with rainfall-generated floods. The precipitation mechanism is also likely in Southern CE, where correlations between the NAO and temperature are low. Finally, in the rest of the study area (Northern CE, Alpine region), a joint precipitation-snow mechanism influences floods not only in winter, but also in the spring/snowmelt period, providing

Raven surgical robot training in preparation for da vinci.

PubMed

Glassman, Deanna; White, Lee; Lewis, Andrew; King, Hawkeye; Clarke, Alicia; Glassman, Thomas; Comstock, Bryan; Hannaford, Blake; Lendvay, Thomas S

2014-01-01

The rapid adoption of robotic assisted surgery challenges the pace at which adequate robotic training can occur due to access limitations to the da Vinci robot. Thirty medical students completed a randomized controlled trial evaluating whether the Raven robot could be used as an alternative training tool for the Fundamentals of Laparoscopic Surgery (FLS) block transfer task on the da Vinci robot. Two groups, one trained on the da Vinci and one trained on the Raven, were tested on a criterion FLS block transfer task on the da Vinci. After robotic FLS block transfer proficiency training there was no statistically significant difference between path length (p=0.39) and economy of motion scores (p=0.06) between the two groups, but those trained on the da Vinci did have faster task times (p=0.01). These results provide evidence for the value of using the Raven robot for training prior to using the da Vinci surgical system for similar tasks.

Construção de um catálogo de aglomerados abertos para estudo da dinâmica da estrutura espiral da Galáxia

NASA Astrophysics Data System (ADS)

Carlos, I. M.; Lépine, J. R. D.

2003-08-01

Os aglomerados abertos são objetos de grande valor para o estudo da dinâmica da Galáxia devido esses objetos terem uma faixa de idade relativamente ampla. O trabalho visa estudar a dinâmica da estrutura espiral da Galáxia principalmente através do uso desses aglomerados, uma vez que o estudo da cinemática desses objetos é fundamental para esse objetivo. Nosso grupo trabalha no sentido de construir uma base de dados de aglomerados abertos contendo coordenadas, distância, idade, movimentos próprios e velocidades radiais e já disponibiliza uma nova versão do catálogo de aglomerados abertos o qual é uma compilação de edições anteriores, principalmente Lynga (1987), Mermilliod (1995) e ESO-B (Lauberts 1982). Nossa amostra possui cerca de 1630 aglomerados, mas nem todos os parâmetros acima citados foram determinados em sua totalidade. Para determinarmos esses parâmetros, derivamos as cores intrínsecas das estrelas membro de cada aglomerado a partir de seus tipos espectrais (busca feita no SIMBAD) obtendo assim o excesso de cor individual. A distribuição dos excessos de cor foi então utilizada para derivarmos o avermelhamento médio para cada aglomerado. De maneira similar, os tipos espectrais foram usados para estimar as magnitudes absolutas, e com as magnitudes absolutas e aparentes determinamos a respectiva distribuição do módulo de distância e finalmente a distância. Para determinar as idades foram confeccionados os diagramas cor-magnitude das estrelas de cada aglomerado onde foram superpostas a Seqüência Principal de Idade Zero (ZAMS). Superpomos a ZAMS de Schmidt-Kaler e isócronas de composição solar. Essas isócronas foram usadas para determinação das idades dos aglomerados. Uma vez que não temos ainda resultados finais, apresentamos então alguns diagramas cor-magnitude os quais foram usados para determinação, principalmente, da distância e idade dos aglomerados.

Tristan da Cunha Island

NASA Image and Video Library

2018-05-25

Tristan da Cunha is both a remote group of volcanic islands in the south Atlantic, and the main island. It is the most remote inhabited island group in the world, 2400 km from the nearest inhabited land. Tristan has a population of about 250 inhabitants, and is part of the British overseas territory of Saint Helena, Ascension and Tristan da Cunha. In 1961 the eruption of Queen Mary's Peak forced the evacuation of the entire population for two years. The image was acquired October 7, 2017, and is located at 37.1 degrees south, 12.3 degrees west. https://photojournal.jpl.nasa.gov/catalog/PIA22506

WRS2 UPA DA Removal

NASA Image and Video Library

2009-11-23

ISS021-E-032275 (23 Nov. 2009) --- NASA astronaut Leland Melvin, STS-129 mission specialist, holds the failed Urine Processor Assembly / Distillation Assembly (UPA DA) in the Destiny laboratory of the International Space Station while space shuttle Atlantis remains docked with the station. Melvin and European Space Agency astronaut Frank De Winne (out of frame), Expedition 21 commander, removed and packed the UPA DA, then transferred it from the Water Recovery System 2 (WRS-2) rack to Atlantis for stowage on the middeck.

North Atlantic Oscillation modulates total ozone winter trends

NASA Astrophysics Data System (ADS)

Appenzeller, Christof; Weiss, Andrea K.; Staehelin, Johannes

2000-04-01

The North Atlantic Oscillation (NAO) is modulating the Earth's ozone shield such that the calculated anthropogenic total ozone decrease is enhanced over Europe whereas over the North Atlantic region it is reduced (for the last 30 years). Including the NAO in a statistical model suggests a more uniform chemical winter trend compared to the strong longitudinal variation reported earlier. At Arosa (Switzerland) the trend is reduced to -2.4% per decade compared to -3.2% and at Reykjavik (Iceland) it is enhanced to -3.8% compared to 0%. The revised trend is slightly below the predictions by 2D chemical models. Decadal ozone variability is linked to variations in the dynamical structure of the atmosphere, as reflected in the tropopause pressure. The latter varies in concert with the NAO index with a distinct geographical pattern.

Red ball ranging optimization based on dual camera ranging method

NASA Astrophysics Data System (ADS)

Kuang, Lei; Sun, Weijia; Liu, Jiaming; Tang, Matthew Wai-Chung

2018-05-01

In this paper, the process of positioning and moving to target red ball by NAO robot through its camera system is analyzed and improved using the dual camera ranging method. The single camera ranging method, which is adapted by NAO robot, was first studied and experimented. Since the existing error of current NAO Robot is not a single variable, the experiments were divided into two parts to obtain more accurate single camera ranging experiment data: forward ranging and backward ranging. Moreover, two USB cameras were used in our experiments that adapted Hough's circular method to identify a ball, while the HSV color space model was used to identify red color. Our results showed that the dual camera ranging method reduced the variance of error in ball tracking from 0.68 to 0.20.

Possibility of the transformation of eEF-2 (100 kDa) to eEF-2 (65 kDa) in the peptide elongation process in vitro.

PubMed

Gajko, A; Sredzińska, K; Galasiński, W; Gindzieński, A

1999-02-16

Two active eEF-2 polypeptides of approximately 100 and 65 kDa were copurified from rat liver cells and separated. The fate of eEF-2 (100 kDa) during its binding to ribosomes and in the translocation step of the peptide elongation process was investigated. It was shown that eEF-2 (100 kDa) did not change its form during the process of binding to the ribosomes. In the postribosomal supernatant, obtained from the postincubation mixture of the elongation process, only eEF-2 (65 kDa) was found. These results suggest that the form of eEF-2 (100 kDa), when bound to the ribosome during the elongation process, is transformed to eEF-2 (65 kDa). Copyright 1999 Academic Press.

[Clinical application of Da Vinci surgical system in China].

PubMed

Jin, Zhenyu

2014-01-01

Da Vinci robotic surgical system leads the development of minimally invasive surgical techniques. By using Da Vinci surgical robot for minimally invasive surgery, it brings a lot of advantages to the surgeons. Since 2008, Da Vinci surgeries have been performed in 14 hospitals in domestic cities such as Beijing and Shanghai. Until the end of 2012, 3 551 cases of Da Vinci robotic surgery have been performed, covering various procedures of various surgical departments including the department of general surgery, urology, cardiovascular surgery, thoracic surgery, gynecology, and etc. Robotic surgical technique has made remarkable achievements.

WRS2 UPA DA Removal

NASA Image and Video Library

2009-11-23

ISS021-E-032273 (23 Nov. 2009) --- European Space Agency astronaut Frank De Winne, Expedition 21 commander, holds the failed Urine Processor Assembly / Distillation Assembly (UPA DA) in the Destiny laboratory of the International Space Station while space shuttle Atlantis remains docked with the station. De Winne and NASA astronaut Leland Melvin (out of frame), STS-129 mission specialist, removed and packed the UPA DA, then transferred it from the Water Recovery System 2 (WRS-2) rack to Atlantis for stowage on the middeck.

[da Vinci surgical system].

PubMed

Watanabe, Gou; Ishikawa, Norihiro

2014-07-01

The da Vinci surgical system was developed by Intuitive Surgical Inc. in the United States as an endoscopic surgical device to assist remote control surgeries. In 1998, the Da Vinci system was first used for cardiothoracic procedures. Currently a combination of robot-assisted internal thoracic artery harvest together with coronary artery bypass grafting (CABG) through a mini-incision (ThoraCAB) or totally endoscopic procedures including anastomoses under robotic assistance (TECAB) are being conducted for the treatment of coronary artery diseases. With the recent advances in catheter interventions, hybrid procedures combining catheter intervention with ThoraCAB or TECAB are anticipated in the future.On the other hand, with the decrease in number of coronary artery bypass surgeries, the share of valvular surgeries is expected to increase in the future. Among them, mitral valvuloplasty for mitral regurgitation is anticipated to be conducted mainly by low-invasive procedures, represented by minimally invasive cardiac surgery( MICS) and robot-assisted surgery. Apart from the intrinsic good surgical view, robotic-assisted systems offer additional advantages of the availability of an amplified view and the easy to observe the mitral valve in the physiological position. Thus, robotic surgical surgeries that make complicated procedures easier are expected to accomplish further developments in the future. Furthermore, while the number of surgeries for atrial septal defects has decreased dramatically following the widespread use of Amplatzer septal occluder, robotic surgery may become a good indication for cases in which the Amplatzer device is not indicated. In Japan, clinical trial of the da Vinci robotic system for heart surgeries has been completed. Statutory approval of the da Vinci system for mitral regurgitation and atrial septal defects is anticipated in the next few years.

NADH:ubiquinone oxidoreductase from bovine heart mitochondria. cDNA sequences of the import precursors of the nuclear-encoded 39 kDa and 42 kDa subunits.

PubMed Central

Fearnley, I M; Finel, M; Skehel, J M; Walker, J E

1991-01-01

The 39 kDa and 42 kDa subunits of NADH:ubiquinone oxidoreductase from bovine heart mitochondria are nuclear-coded components of the hydrophobic protein fraction of the enzyme. Their amino acid sequences have been deduced from the sequences of overlapping cDNA clones. These clones were amplified from total bovine heart cDNA by means of the polymerase chain reaction, with the use of complex mixtures of oligonucleotide primers based upon fragments of protein sequence determined at the N-terminals of the proteins and at internal sites. The protein sequences of the 39 kDa and 42 kDa subunits are 345 and 320 amino acid residues long respectively, and their calculated molecular masses are 39,115 Da and 36,693 Da. Both proteins are predominantly hydrophilic, but each contains one or two hydrophobic segments that could possibly be folded into transmembrane alpha-helices. The bovine 39 kDa protein sequence is related to that of a 40 kDa subunit from complex I from Neurospora crassa mitochondria; otherwise, it is not related significantly to any known sequence, including redox proteins and two polypeptides involved in import of proteins into mitochondria, known as the mitochondrial processing peptidase and the processing-enhancing protein. Therefore the functions of the 39 kDa and 42 kDa subunits of complex I are unknown. The mitochondrial gene product, ND4, a hydrophobic component of complex I with an apparent molecular mass of about 39 kDa, has been identified in preparations of the enzyme. This subunit stains faintly with Coomassie Blue dye, and in many gel systems it is not resolved from the nuclearcoded 36 kDa subunit. Images Fig. 1. PMID:1832859

The 29-kDa proteins phosphorylated ion thrombin-activated human platelets are forms of the estrogen receptor-related 27-kDa heat shock protein

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mendelsohn, M.E.; Yan Zhu; O'Neill, S.

Thrombin plays a critical role in platelet activation, hemostasis, and thrombosis. Cellular activation by thrombin leads to the phosphorylation of multiple proteins, most of which are unidentified. The authors have characterized several 29-kDa proteins that are rapidly phosphorylated following exposure of intact human platelets to thrombin. A murine monoclonal antibody raised to an unidentified estrogen receptor-related 29-kDa protein selectively recognized these proteins as well as a more basic, unphosphorylated 27-kDa protein. Cellular activation by thrombin led to a marked shift in the proportion of protein from the 27-kDa unphosphorylated form to the 29-kDa phosphoprotein species. Using this antibody, they isolatedmore » and sequenced a human cDNA clone encoding a protein that was identical to the mammalian 27-kDa heat shock protein (HSP27), a protein of uncertain function that is known to be phosphorylated to several forms and to be transcriptionally induced by estrogen. The 29-kDa proteins were confirmed to be phosphorylated forms of HSP27 by immunoprecipitation studies. Thus, the estrogen receptor-related protein is HSP27, and the three major 20-kDa proteins phosphorylated in thrombin-activated platelets are forms of HSP27. These data suggest a role for HSP27 in the signal transduction events of platelet activation.« less

DaCHS: Data Center Helper Suite

NASA Astrophysics Data System (ADS)

Demleitner, Markus

2018-04-01

DaCHS, the Data Center Helper Suite, is an integrated package for publishing astronomical data sets to the Virtual Observatory. Network-facing, it speaks the major VO protocols (SCS, SIAP, SSAP, TAP, Datalink, etc). Operator-facing, many input formats, including FITS/WCS, ASCII files, and VOTable, can be processed to publication-ready data. DaCHS puts particular emphasis on integrated metadata handling, which facilitates a tight integration with the VO's Registry

The North Atlantic Oscillation and the ITCZ in a climate simulation

NASA Astrophysics Data System (ADS)

Cavalcanti, I. F. A.; Souza, P.

2009-04-01

The North Atlantic Oscillation (NAO) and the Atlantic Intertropical Convergence Zone (ITCZ) features are analyzed in a climate simulation with the CPTEC/COLA AGCM. The CPTEC/COLA AGCM reproduces the ITCZ seasonal north-south displacement as well as the seasonal east-west intensity, but the model overestimates the convection. The two phases of NAO are well simulated in the four seasons and also the largest intensity in DJF. The main mode of atmospheric variability considering the North and South Atlantic region, which displays a shifting of the NAO centers and a center of action over South Atlantic to the south of Africa is also reproduced. This mode, in DJF, is associated with the north-south ITCZ displacement in April, in the observed data. The displacement of the NAO centers southwestward allows the increase of pressure over the tropical North Atlantic Ocean and the increase of trade winds and displacement of the confluence and convergence zone southwards. The opposite occurs when the centers are displaced northeastward. The model Atlantic ITCZ position in April is associated with the anomalous (observed) Atlantic SST and the southward displacement of the confluence zone, but the simulated atmospheric features in DJF does not display the main mode of variability, as in the observations. This occurs due to the lack of interaction between the atmosphere and ocean in the atmospheric model. While in the observations the physical mechanism that links the NAO centers of action to the ITCZ position is the ocean-atmosphere interaction, from DJF to April, the atmospheric model responds to the prescribed SST at the same month, in April.

Direct Evidence of Solution-Mediated Superoxide Transport and Organic Radical Formation in Sodium-Oxygen Batteries.

PubMed

Xia, Chun; Fernandes, Russel; Cho, Franklin H; Sudhakar, Niranjan; Buonacorsi, Brandon; Walker, Sean; Xu, Meng; Baugh, Jonathan; Nazar, Linda F

2016-09-07

Advanced large-scale electrochemical energy storage requires cost-effective battery systems with high energy densities. Aprotic sodium-oxygen (Na-O2) batteries offer advantages, being comprised of low-cost elements and possessing much lower charge overpotential and higher reversibility compared to their lithium-oxygen battery cousins. Although such differences have been explained by solution-mediated superoxide transport, the underlying nature of this mechanism is not fully understood. Water has been suggested to solubilize superoxide via formation of hydroperoxyl (HO2), but direct evidence of these HO2 radical species in cells has proven elusive. Here, we use ESR spectroscopy at 210 K to identify and quantify soluble HO2 radicals in the electrolyte-cold-trapped in situ to prolong their lifetime-in a Na-O2 cell. These investigations are coupled to parallel SEM studies that image crystalline sodium superoxide (NaO2) on the carbon cathode. The superoxide radicals were spin-trapped via reaction with 5,5-dimethyl-pyrroline N-oxide at different electrochemical stages, allowing monitoring of their production and consumption during cycling. Our results conclusively demonstrate that transport of superoxide from cathode to electrolyte leads to the nucleation and growth of NaO2, which follows classical mechanisms based on the variation of superoxide content in the electrolyte and its correlation with the crystallization of cubic NaO2. The changes in superoxide content upon charge show that charge proceeds through the reverse solution process. Furthermore, we identify the carbon-centered/oxygen-centered alkyl radicals arising from attack of these solubilized HO2 species on the diglyme solvent. This is the first direct evidence of such species, which are likely responsible for electrolyte degradation.

Contribution to the scintillation detection optimization in double phase detectors for direct detection of dark matter

NASA Astrophysics Data System (ADS)

Balan, Catalin

Na ultima decada, foram feitos grandes progressos no desenvolvimento dos detetores de detecao direta das particulas que constituem a materia negra. Com estrategias do aumento gradual do volume do alvo e, simultaneamente, de reducao dos niveis de fundo, a experiencia XENON obteve resultados muito bons e perspetivas promissoras para a detecao de materia negra. Tarefas relativas a analise de dados experimentais adquiridos com o detetor de dupla fase em uso, assim como as simulacoes do campo eletrico, desenvolvimento, montagem e testes para o proximo detetor XENON1T, assim como a participacao regular na manutencao geral e monitorizacao do prototipo atual XENON100 no LNGS, constituiram o plano de trabalhos para as atividades de investigacao do presente doutoramento e a minha contribuicao para a otimizacao da detecao de cintilacao nos detetores da experiencia XENON. A necessidade de alcancar niveis elevados de sensibilidade, requer inovacao em todos os aspetos fisicos do detetor, assim como a reducao de todas as fontes de radioatividade que contribuem para o fundo. O modo mais indicado de operacao para os detetores com enchimento a Xe no estado liquido e gasoso envolve a medicao da cintilacao primaria e da secundaria provenientes da interacao das particulas no Xe liquido. A razao entre estes dois sinais permite diferenciar claramente a maior parte dos eventos correspondentes as fundo dos eventos correspondentes a WIMPs. Deste modo, a leitura dos sinais correspondentes a cintilacao e de extrema importancia. A amplitude do sinal de cintilacao antes dos fotossensores e maximizada atraves da otimizacao de varios parametros, tais como a geometria do alvo do detetor, a transparencia das grelhas dos eletrodos, a uniformidade do ganho em cintilacao secundaria e a utilizacao de material reflectivo para cobrir as superficies que nao sao fotossensiveis.

Self-referencing thermometry in the nanoscale =

NASA Astrophysics Data System (ADS)

Brites, Carlos Antonio Delgado Sousa

Na ultima decada emergiu uma linha de investigacao muito activa em termometros nao invasivos e precisos que possam determinar temperatura a escala nanometrica. Esta investigacao foi fortemente estimulada pelas numerosas solicitacoes da nanotecnologia e da biomedicina, por exemplo. Uma das abordagens mais promissoras propoe o uso de ioes trivalentes de lantanideos que apresenta propriedades fotoluminescentes que dependem da temperatura. Neste trabalho demonstra-se que esta tecnica combina as vantagens de te um limite de deteccao de 0.5 graus com sensibilidade ate 4.5 % K-1. Este termometro molecular pode ser processado em filmes finos ou nanoparticulas, abrindo os campos de aplicacao a diferentes utilizacoes. As nanoparticulas de silica produzidas sao caracterizadas na presenca e na ausencia de ioes lantanideos. Sem o metal, as nanoparticulas de APTES/TEOS demonstram ser luminescentes sob excitacao UV sem necessidade de utilizar qualquer tratamento termico. O rendimento quantico de emissao depende apenas da proporcao dos silanos e pode atingir o valor de 0.15 +/- 0.02. A co-dopagem destas nanoparticulas com Eu3+ e Tb3+ permite obter sondas com resposta raciometrica, com a possibilidade de ajustar a gama de temperaturas de operacao e a sensibilidade, via desenho inteligente da matriz de suporte e dos ligandos de beta-dicetona que estao coordenados ao iao metalico. Quando processados como filmes, este termometro permite o mapeamento de temperaturas com resolucao espacial 1.8 mum. A racionalizacao da dependencia de temperatura e uma ferramenta util para desenvolver termometros que operam em gamas de temperatura especificos (e.g. gama de temperatura fisiologica, 290-340 K) com sensibilidade acima de 0.5 % K-1. A combinacao de esforcos de um grande numero de diversas disciplinas ira previsivelmente permitir o surgimento de termometros moleculares novos e sofisticados, preenchendo os principais requisitos das nanociencias.

Respostas religiosas à aids no Brasil: impressões de pesquisa acerca da Pastoral de DST/Aids da Igreja Católica1

PubMed Central

Seffner, Fernando; Silva, Cristiane Gonçalves Meireles da; Maksud, Ívia; Garcia, Jonathan; Rios, Luís Felipe; Natividade, Marcelo; Borges, Priscila Rodrigues; Parker, Richard; Terto, Veriano

2009-01-01

O texto encontra-se estruturado em quatro partes. Na primeira delas, apresentamos um conjunto de considerações e informações acerca da situação da aids no Brasil, das relações entre religião, sexualidade, aids e estado laico, bem como uma descrição mais clara do Projeto Respostas Religiosas ao HIV/Aids no Brasil, do qual este texto apresenta algumas impressões de pesquisa preliminares. A seguir, dedicamos um item a apresentação da Pastoral de DST/Aids, sua história, estrutura e objetivos. No item seguinte problematizamos diversas questões em particular no âmbito das relações Estado e Igreja, relações entre agentes de pastoral e hierarquia da Igreja, e questões ligadas mais diretamente à sexualidade e aids, todas referenciadas ao trabalho da Pastoral de DST/Aids. Ao final, apresentamos a bibliografia e fontes consultadas. PMID:20442806

How localized is ``local?'' Efficiency vs. accuracy of O(N) domain decomposition in local orbital based all-electron electronic structure theory

NASA Astrophysics Data System (ADS)

Havu, Vile; Blum, Volker; Scheffler, Matthias

2007-03-01

Numeric atom-centered local orbitals (NAO) are efficient basis sets for all-electron electronic structure theory. The locality of NAO's can be exploited to render (in principle) all operations of the self-consistency cycle O(N). This is straightforward for 3D integrals using domain decomposition into spatially close subsets of integration points, enabling critical computational savings that are effective from ˜tens of atoms (no significant overhead for smaller systems) and make large systems (100s of atoms) computationally feasible. Using a new all-electron NAO-based code,^1 we investigate the quantitative impact of exploiting this locality on two distinct classes of systems: Large light-element molecules [Alanine-based polypeptide chains (Ala)n], and compact transition metal clusters. Strict NAO locality is achieved by imposing a cutoff potential with an onset radius rc, and exploited by appropriately shaped integration domains (subsets of integration points). Conventional tight rc<= 3å have no measurable accuracy impact in (Ala)n, but introduce inaccuracies of 20-30 meV/atom in Cun. The domain shape impacts the computational effort by only 10-20 % for reasonable rc. ^1 V. Blum, R. Gehrke, P. Havu, V. Havu, M. Scheffler, The FHI Ab Initio Molecular Simulations (aims) Project, Fritz-Haber-Institut, Berlin (2006).

Na3Tb(PO4)2: Synthesis, crystal structure and greenish emitting properties

NASA Astrophysics Data System (ADS)

Zhao, Dan; Ma, Zhao; Liu, Bao-Zhong; Zhang, Rui-Juan; Wu, Zhi-Qiang; Wang, Jian; Duan, Pei-Gao

2018-03-01

A anhydrous orthoborate Na3Tb(PO4)2 has been prepared and its crystal structure was determined by X-Ray diffraction of a non-merohedral twinned single crystal. The results show that the compound crystallizes in monoclinic space group C2/c and the structure features a 3D framework containing PO4, NaO6, NaO7, NaO8 and TbO8 polyhedra. Under near-UV excitation (370 nm), Na3Tb(PO4)2 shows intense characteristic emission bands of Tb3+ (490 nm, 543 nm, 585 nm and 620 nm) with the CIE coordinate of (0.3062, 0.5901), corresponding to greenish color. The excitation spectrum covers a wide range from 340 nm to 390 nm, which indicates that phosphor Na3Tb(PO4)2 can be efficiently activated by near-UV LED ship.

Slow walking model for children with multiple disabilities via an application of humanoid robot

NASA Astrophysics Data System (ADS)

Wang, ZeFeng; Peyrodie, Laurent; Cao, Hua; Agnani, Olivier; Watelain, Eric; Wang, HaoPing

2016-02-01

Walk training research with children having multiple disabilities is presented. Orthosis aid in walking for children with multiple disabilities such as Cerebral Palsy continues to be a clinical and technological challenge. In order to reduce pain and improve treatment strategies, an intermediate structure - humanoid robot NAO - is proposed as an assay platform to study walking training models, to be transferred to future special exoskeletons for children. A suitable and stable walking model is proposed for walk training. It would be simulated and tested on NAO. This comparative study of zero moment point (ZMP) supports polygons and energy consumption validates the model as more stable than the conventional NAO. Accordingly direction variation of the center of mass and the slopes of linear regression knee/ankle angles, the Slow Walk model faithfully emulates the gait pattern of children.

PCA as a practical indicator of OPLS-DA model reliability.

PubMed

Worley, Bradley; Powers, Robert

Principal Component Analysis (PCA) and Orthogonal Projections to Latent Structures Discriminant Analysis (OPLS-DA) are powerful statistical modeling tools that provide insights into separations between experimental groups based on high-dimensional spectral measurements from NMR, MS or other analytical instrumentation. However, when used without validation, these tools may lead investigators to statistically unreliable conclusions. This danger is especially real for Partial Least Squares (PLS) and OPLS, which aggressively force separations between experimental groups. As a result, OPLS-DA is often used as an alternative method when PCA fails to expose group separation, but this practice is highly dangerous. Without rigorous validation, OPLS-DA can easily yield statistically unreliable group separation. A Monte Carlo analysis of PCA group separations and OPLS-DA cross-validation metrics was performed on NMR datasets with statistically significant separations in scores-space. A linearly increasing amount of Gaussian noise was added to each data matrix followed by the construction and validation of PCA and OPLS-DA models. With increasing added noise, the PCA scores-space distance between groups rapidly decreased and the OPLS-DA cross-validation statistics simultaneously deteriorated. A decrease in correlation between the estimated loadings (added noise) and the true (original) loadings was also observed. While the validity of the OPLS-DA model diminished with increasing added noise, the group separation in scores-space remained basically unaffected. Supported by the results of Monte Carlo analyses of PCA group separations and OPLS-DA cross-validation metrics, we provide practical guidelines and cross-validatory recommendations for reliable inference from PCA and OPLS-DA models.

DA-6034 Induces [Ca(2+)]i Increase in Epithelial Cells.

PubMed

Yang, Yu-Mi; Park, Soonhong; Ji, Hyewon; Kim, Tae-Im; Kim, Eung Kweon; Kang, Kyung Koo; Shin, Dong Min

2014-04-01

DA-6034, a eupatilin derivative of flavonoid, has shown potent effects on the protection of gastric mucosa and induced the increases in fluid and glycoprotein secretion in human and rat corneal and conjunctival cells, suggesting that it might be considered as a drug for the treatment of dry eye. However, whether DA-6034 induces Ca(2+) signaling and its underlying mechanism in epithelial cells are not known. In the present study, we investigated the mechanism for actions of DA-6034 in Ca(2+) signaling pathways of the epithelial cells (conjunctival and corneal cells) from human donor eyes and mouse salivary gland epithelial cells. DA-6034 activated Ca(2+)-activated Cl(-) channels (CaCCs) and increased intracellular calcium concentrations ([Ca(2+)]i) in primary cultured human conjunctival cells. DA-6034 also increased [Ca(2+)]i in mouse salivary gland cells and human corneal epithelial cells. [Ca(2+)]i increase of DA-6034 was dependent on the Ca(2+) entry from extracellular and Ca(2+) release from internal Ca(2+) stores. Interestingly, these effects of DA-6034 were related to ryanodine receptors (RyRs) but not phospholipase C/inositol 1,4,5-triphosphate (IP3) pathway and lysosomal Ca(2+) stores. These results suggest that DA-6034 induces Ca(2+) signaling via extracellular Ca(2+) entry and RyRs-sensitive Ca(2+) release from internal Ca(2+) stores in epithelial cells.

A Influência da Escola e da Mídia na Obtenção dos Conhecimentos Astronômicos

NASA Astrophysics Data System (ADS)

da Cunha, W. S.; Voelzke, M. R.; Amaral, L. H.

2006-08-01

O universo em que vivemos possui segredos jamais imaginados pelo homem, fruto da pequena proporção que ocupamos diante de um cosmos infinito. A astronomia funciona como um instrumento que sacia a sede humana em desvendar esses segredos, estudando as galáxias, quasares, pulsares além da existência de todos os elementos que preenchem o espaço cósmico, o vácuo, não mais vazio como se pensou em outros tempos. A mídia explora esse campo de forma mística e também científica. A difusão adequada e dentro dos padrões educacionais vigentes, de conceitos astronômicos, se faz necessária, devido sua presença nos conteúdos escolares, centros de ciência e na mídia, de modo geral. A reforma do Currículo Básico da Escola Pública da maioria dos Estados brasileiros introduziu conceitos astronômicos desde a pré-escola até o Ensino Médio. Num estudo realizado com 1.032 alunos do Ensino Médio de seis escolas estaduais, revelou-se através da aplicação de um questionário que abordava conheciment os básicos em astronomia, como estes foram adquiridos e qual era a infra-estrutura oferecida pela escola: para 66,2% dos entrevistados o professor já fez alguma apresentação a respeito de astronomia. O presente estudo revelou também que 44,5% dos alunos entrevistados adquiriram seus conhecimentos astronômicos na escola, 28,1% através da televisão e 27,4% afirmaram que seus conhecimentos foram obtidos através de outros tipos de mídia (internet, filmes e revistas). Embora o estudo revele claramente que há certo equilíbrio na forma em que os alunos obtiveram seus conhecimentos astronômicos, a mídia ainda explora e muitas vezes desperta o interesse pela astronomia com assuntos que não fazem parte de nosso cotidiano como, por exemplo, o homem na Lua, os projetos espaciais e a primeira viagem de um astronauta brasileiro no espaço. Porém, em certos casos, a mídia pode promover conhecimentos incompletos ou mesmo equivocados sobre os conceitos que envolvam

32 CFR 516.25 - DA Form 4.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 32 National Defense 3 2013-07-01 2013-07-01 false DA Form 4. 516.25 Section 516.25 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY AID OF CIVIL AUTHORITIES AND PUBLIC... attached to a properly prepared and sealed DA Form 4 are self-authenticating. (See Fed. R. Evid. 902). (b...

32 CFR 516.25 - DA Form 4.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 32 National Defense 3 2014-07-01 2014-07-01 false DA Form 4. 516.25 Section 516.25 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY AID OF CIVIL AUTHORITIES AND PUBLIC... attached to a properly prepared and sealed DA Form 4 are self-authenticating. (See Fed. R. Evid. 902). (b...

32 CFR 516.25 - DA Form 4.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 3 2011-07-01 2009-07-01 true DA Form 4. 516.25 Section 516.25 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY AID OF CIVIL AUTHORITIES AND PUBLIC RELATIONS... properly prepared and sealed DA Form 4 are self-authenticating. (See Fed. R. Evid. 902). (b) Preparation at...

32 CFR 516.25 - DA Form 4.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 32 National Defense 3 2012-07-01 2009-07-01 true DA Form 4. 516.25 Section 516.25 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY AID OF CIVIL AUTHORITIES AND PUBLIC RELATIONS... properly prepared and sealed DA Form 4 are self-authenticating. (See Fed. R. Evid. 902). (b) Preparation at...

DA1 receptors modulation in rat isolated trachea.

PubMed

Cabezas, Gloria A; Velasco, Manuel

2010-01-01

We have previously demonstrated that low dose of inhaled dopamine (0.5-2 microg kg(-1) min(-1)) induces broncodilatacion in patients with acute asthma attack, suggesting that this dopamine effect is mediated by dopaminergic rather than by adrenergic receptors. To understand better these dopamine effect, rat tracheal smooth muscle was used as a model to evaluate the responses of beta2-, alpha1-, alpha2-adrenergic and DA1 and DA2 dopaminergic antagonists. Tracheal rings from male Sprague-Dawley rats (n = 90) were excised and placed in an organ bath containing modified Krebs-Ringer bicarbonate buffer at 37 degrees C, and gassed with O2 (95%) and CO2 (5%). Contractile responses were recorded with an isometric transducer in a polygraph (Letica, Spain). Contraction was induced by accumulative doses of acetylcholine (0.1, 0.3, 1, 3, 10 mM) or by electric field stimulation (10 Hz at 2 milliseconds), and accumulative doses of dopamine were added to the bath. Low concentration (0.1-0.3 mM) elicited a small initial contraction, followed by a marked relaxation. Cholinergic contraction was completely reversed at 6 mM of dopamine. This biphasic dopaminergic response was not blocked by incubation with beta2-adrenergic antagonist propranolol (0.1 microM), alpha1-antagonist, terazosin (0.1 mM), alpha2-antagonist, yohimbine (0.1 mM), or by DA2 antagonist metoclopramide (1-8 mM); DA1 antagonist SCH23390 (0.1 microM) produced a sustained increase of basal tone but did not block initial dopaminergic contraction and partially inhibited bronchodilator effect of dopamine. Dopaminergic relaxation in rat trachea is mediated by DA1 rather than by DA2 receptors; and adrenergic receptors are not involved in such dopamine-induced response. Finally, DA1 antagonist SCH23390 exerts intrinsic contractile activity on airway smooth muscle that deserves further research.

Tree Branching: Leonardo da Vinci's Rule versus Biomechanical Models

PubMed Central

Minamino, Ryoko; Tateno, Masaki

2014-01-01

This study examined Leonardo da Vinci's rule (i.e., the sum of the cross-sectional area of all tree branches above a branching point at any height is equal to the cross-sectional area of the trunk or the branch immediately below the branching point) using simulations based on two biomechanical models: the uniform stress and elastic similarity models. Model calculations of the daughter/mother ratio (i.e., the ratio of the total cross-sectional area of the daughter branches to the cross-sectional area of the mother branch at the branching point) showed that both biomechanical models agreed with da Vinci's rule when the branching angles of daughter branches and the weights of lateral daughter branches were small; however, the models deviated from da Vinci's rule as the weights and/or the branching angles of lateral daughter branches increased. The calculated values of the two models were largely similar but differed in some ways. Field measurements of Fagus crenata and Abies homolepis also fit this trend, wherein models deviated from da Vinci's rule with increasing relative weights of lateral daughter branches. However, this deviation was small for a branching pattern in nature, where empirical measurements were taken under realistic measurement conditions; thus, da Vinci's rule did not critically contradict the biomechanical models in the case of real branching patterns, though the model calculations described the contradiction between da Vinci's rule and the biomechanical models. The field data for Fagus crenata fit the uniform stress model best, indicating that stress uniformity is the key constraint of branch morphology in Fagus crenata rather than elastic similarity or da Vinci's rule. On the other hand, mechanical constraints are not necessarily significant in the morphology of Abies homolepis branches, depending on the number of daughter branches. Rather, these branches were often in agreement with da Vinci's rule. PMID:24714065

Tree branching: Leonardo da Vinci's rule versus biomechanical models.

PubMed

Minamino, Ryoko; Tateno, Masaki

2014-01-01

This study examined Leonardo da Vinci's rule (i.e., the sum of the cross-sectional area of all tree branches above a branching point at any height is equal to the cross-sectional area of the trunk or the branch immediately below the branching point) using simulations based on two biomechanical models: the uniform stress and elastic similarity models. Model calculations of the daughter/mother ratio (i.e., the ratio of the total cross-sectional area of the daughter branches to the cross-sectional area of the mother branch at the branching point) showed that both biomechanical models agreed with da Vinci's rule when the branching angles of daughter branches and the weights of lateral daughter branches were small; however, the models deviated from da Vinci's rule as the weights and/or the branching angles of lateral daughter branches increased. The calculated values of the two models were largely similar but differed in some ways. Field measurements of Fagus crenata and Abies homolepis also fit this trend, wherein models deviated from da Vinci's rule with increasing relative weights of lateral daughter branches. However, this deviation was small for a branching pattern in nature, where empirical measurements were taken under realistic measurement conditions; thus, da Vinci's rule did not critically contradict the biomechanical models in the case of real branching patterns, though the model calculations described the contradiction between da Vinci's rule and the biomechanical models. The field data for Fagus crenata fit the uniform stress model best, indicating that stress uniformity is the key constraint of branch morphology in Fagus crenata rather than elastic similarity or da Vinci's rule. On the other hand, mechanical constraints are not necessarily significant in the morphology of Abies homolepis branches, depending on the number of daughter branches. Rather, these branches were often in agreement with da Vinci's rule.

40 CFR 60.42Da - Standard for particulate matter (PM).

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 6 2010-07-01 2010-07-01 false Standard for particulate matter (PM). 60.42Da Section 60.42Da Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR....42Da Standard for particulate matter (PM). (a) On and after the date on which the initial performance...

40 CFR 60.42Da - Standard for particulate matter (PM).

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 6 2011-07-01 2011-07-01 false Standard for particulate matter (PM). 60.42Da Section 60.42Da Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR....42Da Standard for particulate matter (PM). (a) On and after the date on which the initial performance...

Changes in deep-sea fish and crustacean communities at 1000-2200 m in the Western Mediterranean after 25 years: Relation to hydro-climatic conditions

NASA Astrophysics Data System (ADS)

Cartes, J. E.; Maynou, F.; Fanelli, E.; López-Pérez, C.; Papiol, V.

2015-03-01

Long-term changes in the biomass, diversity and composition of deep-living fish and decapods from the Balearic Basin (western Mediterranean) have been compared between two periods, 1985-1992 vs. 2007-2012, based on 106 bottom trawls performed at 1000-2250 m. Relationships have been identified between the changes in community composition and the hydroclimatic conditions (e.g. NAO, temperature, salinity and dissolved O2) of the area. We found a generalized deepening of middle-slope communities (950-1250 m), especially among decapods, which is suggested (from GLM results) to have been a response to the long-term increase in salinity of the Levantine Intermediate Waters (LIW), located above the level sampled to ca. 700 m. Even more pronounced was the shallowing of all of the lower slope species (1600-2250 m), accompanied by a significant decrease of biomass from 1985-1992 to 2007-2012. This last tendency would be done to a combination of factors: long-term decrease of O2 in the bottom-boundary layer, greater degradation of POM arriving on the bottom due to temperature increase in the Western Mediterranean Deep Waters (WMDW) and probably a decrease of Chl a at the surface and, thus, of production. The influence of climatic oscillations (NAO) on differences found between 1985-1992 and 2007-2012 seems secondary, likely because the NAO did not show significant differences between the two periods. Some plankton-feeding species showed an increase of density during high/positive NAO (e.g. Alepocephalus rostratus), while some benthos feeders increased during low/negative NAO (e.g. Aristeus antennatus, mainly juveniles). The increase of rainfall and advective fluxes under low/negative NAO (i.e., in 2007-2012) may increase the formation of the nepheloid layer identified over 1200-1400 m in the area (Cartes et al., 2013a), linked to zooplankton aggregation in that depth range. Greater food availability could explain the generalized migration by both middle and lower slope species

The North Atlantic Oscillation as a driver of multidecadal variability of the AMOC, the AMO, and Northern Hemisphere climate

NASA Astrophysics Data System (ADS)

Delworth, T. L.; Zeng, F. J.; Yang, X.; Zhang, L.

2017-12-01

We use suites of simulations with coupled ocean-atmosphere models to show that multidecadal changes in the North Atlantic Oscillation (NAO) can drive multidecadal changes in the Atlantic Meridional Overturning Circulation (AMOC) and the Atlantic Multidecadal Oscillation (AMO), with associated hemispheric climatic impacts. These impacts include rapid changes in Arctic sea ice, hemispheric temperature, and modulation of Atlantic hurricane activity. We use models that incorporate either a fully dynamic ocean or a simple slab ocean to explore the role of ocean dynamics and ocean-atmosphere interactions. A positive phase of the NAO is associated with strengthened westerly winds over the North Atlantic. These winds extract more heat than normal from the subpolar ocean, thereby increasing upper ocean density, deepwater formation, and the strength of the AMOC and associated poleward ocean heat transport. This warming leads to a positive phase of the AMO. The enhanced oceanic heat transport extends to the Arctic where it causes a reduction of Arctic sea ice. Large-scale atmospheric warming reduces vertical wind shear in the tropical North Atlantic, creating an environment more favorable for tropical storms. We use models to further show that observed multidecadal variations of the NAO over the 20th and early 21st centuries may have led to multidecadal variations of simulated AMOC and the AMO. Specifically, negative NAO values from the late 1960s through the early 1980s led to a weakened AMOC/cold North Atlantic, whereas increasing NAO values from the late 1980s through the late 1990s increased the model AMOC and led to a positive (warm) phase of the AMO. The warm phase contributed to increases in tropical storm activity and decreases in Arctic sea ice after the mid 1990s. Ocean dynamics are essential for translating the observed NAO variations into ocean heat content variations for the extratropical North Atlantic, but appear less important in the tropical North Atlantic

The evolution of the North Atlantic Oscillation for the last 700 years inferred from D/H isotopes in the sedimentary record of Lake Azul (Azores archipelago, Portugal).

NASA Astrophysics Data System (ADS)

Rubio de Ingles, Maria Jesus; Shanahan, Timothy M.; Sáez, Alberto; José Pueyo, Juan; Raposeiro, Pedro M.; Gonçalves, Vitor M.; Hernández, Armand; Trigo, Ricardo; Sánchez López, Guiomar; Francus, Pierre; Giralt, Santiago

2015-04-01

The δD plant leaf wax variations provide insights on precipitation and evaporation evolution through time. This proxy has been used to reconstruct the temporal evolution of the North Atlantic Oscillation (NAO) climate mode since this mode rules most of the climate variability in the central North Atlantic area. A total lipid extraction preparation and the correspondent analyses in the IRMS have been done for 100 samples from the uppermost 1.5 m of the sedimentary infill of Lake Azul (Azores archipelago, Portugal). According to the chronological model, established by 210Pb profile and 4 AMS 14C dates, this record contains the environmental history of the last 730 years. The reconstructed precipitation variations obtained from D/H isotope values, suggest that this area has suffered significant changes in its distribution and intensity rainfall patterns through time. The end of the Medieval Climate Anomaly (MCA, 1100- 1300 AD) is characterized by a progressive enrichmentof D/H isotope values which meant decreasing arid conditions. These rainfalls' increase might be interpreted by a shift from positive to negative dominance of the NAO. The Little Ice Age (LIA, 1300 - 1850 AD) was characterized by two humid periods (1300- 1550 AD and 1650 - 1850 AD) separated by a relatively dry period. These precipitation oscillations are clearly visible by marked changes in the D/H isotope values. The LIA was followed by the persistence of the positive NAO mode, exhibited by the depletion of the D/H isotope signal, which indicated an overall decrease of the precipitation in the central North Atlantic area. Surprisingly, the D/H of the last 100 years, characterized by the present global warming and a persistent positive NAO mode, display large fluctuations most possibly linked to an enhancement of the storminess which is in concordance with the data fluctuations observed in the instrumental record for the last 80 years in the archipelago. This climatic evolution is in accordance with

Atmospheric mechanisms governing the spatial and temporal variability of phenological phases in central Europe

NASA Astrophysics Data System (ADS)

Scheifinger, Helfried; Menzel, Annette; Koch, Elisabeth; Peter, Christian; Ahas, Rein

2002-11-01

A data set of 17 phenological phases from Germany, Austria, Switzerland and Slovenia spanning the time period from 1951 to 1998 has been made available for analysis together with a gridded temperature data set (1° × 1° grid) and the North Atlantic Oscillation (NAO) index time series. The disturbances of the westerlies constitute the main atmospheric source for the temporal variability of phenological events in Europe. The trend, the standard deviation and the discontinuity of the phenological time series at the end of the 1980s can, to a great extent, be explained by the NAO. A number of factors modulate the influence of the NAO in time and space. The seasonal northward shift of the westerlies overlaps with the sequence of phenological spring phases, thereby gradually reducing its influence on the temporal variability of phenological events with progression of spring (temporal loss of influence). This temporal process is reflected by a pronounced decrease in trend and standard deviation values and common variability with the NAO with increasing year-day. The reduced influence of the NAO with increasing distance from the Atlantic coast is not only apparent in studies based on the data set of the International Phenological Gardens, but also in the data set of this study with a smaller spatial extent (large-scale loss of influence). The common variance between phenological and NAO time series displays a discontinuous drop from the European Atlantic coast towards the Alps. On a local and regional scale, mountainous terrain reduces the influence of the large-scale atmospheric flow from the Atlantic via a proposed decoupling mechanism. Valleys in mountainous terrain have the inclination to harbour temperature inversions over extended periods of time during the cold season, which isolate the valley climate from the large-scale atmospheric flow at higher altitudes. Most phenological stations reside at valley bottoms and are thus largely decoupled in their temporal

Potential links between the North Atlantic Oscillation and decreasing precipitation and runoff on a Mediterranean area

NASA Astrophysics Data System (ADS)

Montaldo, Nicola; Sarigu, Alessio

2017-10-01

In the Mediterranean region, the reduction in precipitation and warmer temperatures is generating a desertification process, with dramatic consequences for both agriculture and the sustainability of water resources. On the island of Sardinia (Italy), the decrease in runoff impacts the management of water resources, resulting in water supply restrictions even for domestic consumption. In the 10 Sardinian basins with a longer database (at least 40 complete years of data, including data from the past 10 years), runoff decreased drastically over the 1975-2010 period, with mean yearly runoff reduced by more than 40% compared to the previous 1922-1974 period. Trends in yearly runoff are negative, with Mann-Kendall τ values ranging from -0.39 to -0.2. Decreasing winter precipitation over the 1975-2010 period everywhere on Sardinia island has led to these decreases in runoff, as most yearly runoff in the Sardinian basins (70% on average) is produced by winter precipitation due to the seasonality typical of the Mediterranean climate regime. The trend in winter precipitation is not homogenous; the negative trend is higher (around -0.25) on the west Sardinian coast, becoming lower across the island toward the east coast (around -0.14). Winter precipitation is highly correlated with the North Atlantic Oscillation (NAO), a weather phenomenon in the North Atlantic Ocean that controls the direction and strength of westerly winds and storm tracks into Europe. High negative correlations (up to -0.45) between winter NAO index and winter precipitation are estimated along the west coast. Meanwhile, these correlations decrease east across the island toward the high mountain in the center of Sardinia, reaching the lowest values along the east coast (about -0.25). The generally decreasing correlation between winter NAO index and winter precipitation in the longitudinal direction (from the North Atlantic dipole to the east) here accelerates due to local-scale orographic effects that

Potential links between the North Atlantic Oscillation and decreasing precipitation and runoff on Sardinia

NASA Astrophysics Data System (ADS)

Sarigu, A.; Montaldo, N.

2017-12-01

In the Mediterranean region, the reduction in precipitation and warmer temperatures is generating a desertification process, with dramatic consequences for both agriculture and the sustainability of water resources. On the island of Sardinia (Italy), the decrease in runoff impacts the management of water resources, resulting in water supply restrictions even for domestic consumption. In the 10 Sardinian basins with a longer database (at least 40 complete years of data, including data from the past 10 years), runoff decreased drastically over the 1975-2010 period, with mean yearly runoff reduced by more than 40% compared to the previous 1922-1974 period. Trends in yearly runoff are negative, with Mann-Kendall τ values ranging from -0.39 to -0.2. Decreasing winter precipitation over the 1975-2010 period everywhere on Sardinia island has led to these decreases in runoff, as most yearly runoff in the Sardinian basins (70% on average) is produced by winter precipitation due to the seasonality typical of the Mediterranean climate regime. The trend in winter precipitation is not homogenous; the negative trend is higher (around -0.25) on the west Sardinian coast, becoming lower across the island toward the east coast (around -0.14). Winter precipitation is highly correlated with the North Atlantic Oscillation (NAO), a weather phenomenon in the North Atlantic Ocean that controls the direction and strength of westerly winds and storm tracks into Europe. High negative correlations (up to -0.45) between winter NAO index and winter precipitation are estimated along the west coast. Meanwhile, these correlations decrease east across the island toward the high mountain in the center of Sardinia, reaching the lowest values along the east coast (about -0.25). The decreasing correlation between winter NAO index and winter precipitation in the longitudinal direction (from the North Atlantic dipole to the east) here accelerates due to local-scale orographic effects that overlap the

The role of transparency in da Vinci stereopsis.

PubMed

Zannoli, Marina; Mamassian, Pascal

2011-10-15

The majority of natural scenes contains zones that are visible to one eye only. Past studies have shown that these monocular regions can be seen at a precise depth even though there are no binocular disparities that uniquely constrain their locations in depth. In the so-called da Vinci stereopsis configuration, the monocular region is a vertical line placed next to a binocular rectangular occluder. The opacity of the occluder has been mentioned to be a necessary condition to obtain da Vinci stereopsis. However, this opacity constraint has never been empirically tested. In the present study, we tested whether da Vinci stereopsis and perceptual transparency can interact using a classical da Vinci configuration in which the opacity of the occluder varied. We used two different monocular objects: a line and a disk. We found no effect of the opacity of the occluder on the perceived depth of the monocular object. A careful analysis of the distribution of perceived depth revealed that the monocular object was perceived at a depth that increased with the distance between the object and the occluder. The analysis of the skewness of the distributions was not consistent with a double fusion explanation, favoring an implication of occlusion geometry in da Vinci stereopsis. A simple model that includes the geometry of the scene could account for the results. In summary, the mechanism responsible to locate monocular regions in depth is not sensitive to the material properties of objects, suggesting that da Vinci stereopsis is solved at relatively early stages of disparity processing. Copyright © 2011 Elsevier Ltd. All rights reserved.

Finding of No Significant Impact, Skiffes Creek Federal Navigation Channel Maintenance Dredging, Joint Base Langley-Eustis, Fort Eustis, Virginia

DTIC Science & Technology

2014-06-06

National Marine Fisheries Service Habitat Conservation District 904 South Morris Street Oxford, MD 21654 Dear Mr. Goodger: The U.S. Army...Nadal, Teresita I NAO From: Nadal, Teresita I NAO Sent: Tuesday , February 04, 2014 2:10 PM To: ’David.L.O’Brien@noaa.gov’ Subject: Skiffes Creek EFH...Noaa.gov). Sincerely, DanielS. Morris Acting Regional Administrator File Code: H:\\S7ST1Section 7\\Non-Fisheries\\ACOE\\Infonnal\\20 I2\\Norfolk District

Evaluation of the Atlantic Multidecadal Oscillation Impact on Large-Scale Atmospheric Circulation in the Atlantic Region in Summer

NASA Astrophysics Data System (ADS)

Semenov, V. A.; Cherenkova, E. A.

2018-02-01

The influence of the Atlantic Multidecadal Oscillation (AMO) on large-scale atmospheric circulation in the Atlantic region in summer for the period of 1950-2015 is investigated. It is shown that the intensification of the summer North Atlantic Oscillation (NAO) with significant changes in sea level pressure anomalies in the main centers of action (over Greenland and the British Isles) occurred while the North Atlantic was cooler. Sea surface temperature anomalies, which are linked to the AMO in the summer season, affect both the NAO index and fluctuations of the Eastern Atlantic/Western Russia (EAWR) centers of action. The positive (negative) phase of the AMO is characterized by a combination of negative (positive) values of the NAO and EAWR indices. The dominance of the opposite phases of the teleconnection indices in summer during the warm North Atlantic and in its colder period resulted in differences in the regional climate in Europe.

The Low-Frequency Variability of the Tropical Atlantic Ocean

NASA Technical Reports Server (NTRS)

Haekkinen, Sirpa; Mo, Kingtse C.; Koblinsky, Chester J. (Technical Monitor)

2001-01-01

Upper ocean temperature variability in the tropical Atlantic is examined from the Comprehensive Ocean Atmosphere Data Set (COADS) as well as from an ocean model simulation forced by COADS anomalies appended to a monthly climatology. Our findings are as follows: Only the sea surface temperatures (SST) in the northern tropics are driven by heat fluxes, while the southern tropical variability arises from wind driven ocean circulation changes. The subsurface temperatures in the northern and southern tropics are found to have a strong linkage to buoyancy forcing changes in the northern North Atlantic. Evidence for Kelvin-like boundary wave propagation from the high latitudes is presented from the model simulation. This extratropical influence is associated with wintertime North Atlantic Oscillation (NAO) forcing and manifests itself in the northern and southern tropical temperature anomalies of the same sign at depth of 100-200 meters as result of a Rossby wave propagation away from the eastern boundary in the wake of the boundary wave passage. The most apparent association of the southern tropical sea surface temperature anomalies (STA) arises with the anomalous cross-equatorial winds which can be related to both NAO and the remote influence from the Pacific equatorial region. These teleconnections are seasonal so that the NAO impact on the tropical SST is the largest it mid-winter but in spring and early summer the Pacific remote influence competes with NAO. However, NAO appears to have a more substantial role than the Pacific influence at low frequencies during the last 50 years. The dynamic origin of STA is indirectly confirmed from the SST-heat flux relationship using ocean model experiments which remove either anomalous wind stress forcing or atmospheric forcing anomalies contributing to heat exchange.

European Wintertime Windstorms and its Links to Large-Scale Variability Modes

NASA Astrophysics Data System (ADS)

Befort, D. J.; Wild, S.; Walz, M. A.; Knight, J. R.; Lockwood, J. F.; Thornton, H. E.; Hermanson, L.; Bett, P.; Weisheimer, A.; Leckebusch, G. C.

2017-12-01

Winter storms associated with extreme wind speeds and heavy precipitation are the most costly natural hazard in several European countries. Improved understanding and seasonal forecast skill of winter storms will thus help society, policy-makers and (re-) insurance industry to be better prepared for such events. We firstly assess the ability to represent extra-tropical windstorms over the Northern Hemisphere of three seasonal forecast ensemble suites: ECMWF System3, ECMWF System4 and GloSea5. Our results show significant skill for inter-annual variability of windstorm frequency over parts of Europe in two of these forecast suites (ECMWF-S4 and GloSea5) indicating the potential use of current seasonal forecast systems. In a regression model we further derive windstorm variability using the forecasted NAO from the seasonal model suites thus estimating the suitability of the NAO as the only predictor. We find that the NAO as the main large-scale mode over Europe can explain some of the achieved skill and is therefore an important source of variability in the seasonal models. However, our results show that the regression model fails to reproduce the skill level of the directly forecast windstorm frequency over large areas of central Europe. This suggests that the seasonal models also capture other sources of variability/predictability of windstorms than the NAO. In order to investigate which other large-scale variability modes steer the interannual variability of windstorms we develop a statistical model using a Poisson GLM. We find that the Scandinavian Pattern (SCA) in fact explains a larger amount of variability for Central Europe during the 20th century than the NAO. This statistical model is able to skilfully reproduce the interannual variability of windstorm frequency especially for the British Isles and Central Europe with correlations up to 0.8.

Effect of Alkali Metal Cations on Slow Inactivation of Cardiac Na+ Channels

PubMed Central

Townsend, Claire; Horn, Richard

1997-01-01

Human heart Na+ channels were expressed transiently in both mammalian cells and Xenopus oocytes, and Na+ currents measured using 150 mM intracellular Na+. The kinetics of decaying outward Na+ current in response to 1-s depolarizations in the F1485Q mutant depends on the predominant cation in the extracellular solution, suggesting an effect on slow inactivation. The decay rate is lower for the alkali metal cations Li+, Na+, K+, Rb+, and Cs+ than for the organic cations Tris, tetramethylammonium, N-methylglucamine, and choline. In whole cell recordings, raising [Na+]o from 10 to 150 mM increases the rate of recovery from slow inactivation at −140 mV, decreases the rate of slow inactivation at relatively depolarized voltages, and shifts steady-state slow inactivation in a depolarized direction. Single channel recordings of F1485Q show a decrease in the number of blank (i.e., null) records when [Na+]o is increased. Significant clustering of blank records when depolarizing at a frequency of 0.5 Hz suggests that periods of inactivity represent the sojourn of a channel in a slow-inactivated state. Examination of the single channel kinetics at +60 mV during 90-ms depolarizations shows that neither open time, closed time, nor first latency is significantly affected by [Na+]o. However raising [Na+]o decreases the duration of the last closed interval terminated by the end of the depolarization, leading to an increased number of openings at the depolarized voltage. Analysis of single channel data indicates that at a depolarized voltage a single rate constant for entry into a slow-inactivated state is reduced in high [Na+]o, suggesting that the binding of an alkali metal cation, perhaps in the ion-conducting pore, inhibits the closing of the slow inactivation gate. PMID:9234168

Considerations on the role of cardiolipin in cellular responses to PDT

NASA Astrophysics Data System (ADS)

Morris, Rachel L.; Azizuddin, Kashif; Berlin, Jeffrey C.; Burda, Clemens; Kenney, Malcolm E.; Samia, Anna C. S.; Oleinick, Nancy L.

2004-06-01

Cardiolipin is a unique phospholipid containing two phosphatidyl glycerol moieties and four fatty acids per molecule. It is found exclusively in the mitochondrial inner membrane and at the contact sites between the inner and outer membranes. The acridine derivative, nonyl-acridine orange (NAO), is a highly specific probe of cardiolipin, with a binding affinity approximately two orders of magnitude greater than that for binding to other anionic phospholipids. We recently reported that when NAO is bound in the mitochondria of human prostate cancer PC-3 cells and activated at 488 nm, NAO could transfer fluorescence resonance energy to the phthalocyanine photosensitizer Pc 4. This observation indicates that one site of Pc 4 binding is very near to NAO and therefore very near to cardiolipin. The average distance between the two fluorophores was calculated to be 7 nm. In the present study, we have extended the observation to the endogenously synthesized photosensitizer, protoporphyrin IX, an intermediate in heme biosynthesis that is used for photodynamic therapy of several types of malignant and non-malignant conditions. Protoporphyrin IX is generated in the mitochondria but is known to bind to other cellular sites as well, especially the endoplasmic reticulum. The ability of this molecule to accept resonance energy from NAO in cells is consistent with a localization of at least some of the molecules in the mitochondria either on the inner membrane, the site of cardiolipin, or within about 10 nm of it. Since protoporphyrin IX binds with high affinity to the peripheral benzodiazepine receptor, a component of the permeability transition pore complex that forms at contact sites between the inner and outer membranes, our observations provide evidence for the close association of several critical molecules for mitochondrial functions and suggest that cardiolipin may be an early oxidative target during PDT with at least two photosensitizers.

Effect of shorter dark adaptation on ISCEV standard DA 0.01 and DA 3 skin ERGs in healthy adults.

PubMed

Hamilton, R; Graham, K

2016-08-01

To quantify dark-adapted (DA) skin ERG changes during 20 min of dark adaptation. Sixteen healthy adult subjects were dark-adapted for 20 min during which ISCEV standard dim (0.01 phot cd s m(-2)) white flash ERGs were recorded at 1, 2, 3, 4, 5, 10, 15 and 20 min, and bright (3 phot cd s m(-2)) white ERGs were recorded at 2, 5, 10, 15 and 20 min without mydriasis and using skin electrodes. Amplitudes and peak times were normalised to 20 min values. Halving dark adaptation from 20 to 10 min had no measureable effect on the DA 3 ERG and caused a 10 % amplitude loss (range 0-23 %) only for the DA 0.01 ERG b-wave amplitude. No significant peak time changes resulted, nor increased parameter variability. Reducing dark adaptation from 20 to 10 min or even less has an effect on only DA 0.01 ERGs. Shorter dark adaptation than 20 min may not compromise the clinical utility of the ERG providing clinics adhere to the usual standards of adequate reference data.

Effect of Ocean Tide Models on the Precise Orbit Determination of Geodetic Satellites

NASA Astrophysics Data System (ADS)

Kubo-Oka, T.; Matsumoto, K.; Otsubo, T.; Gotoh, T.

2005-12-01

Several ocean tide models are tested with precise observation data of satellite laser ranging to geodetic satellites, Starlette and Stella. Four ocean models, NAO.99b, CSR 3.0 (standard model in IERS Conventions 2003), CSR 4.0, and GOT99.2b were implemented in our orbit analysis software "concerto ver. 4". NAO.99b model was developed by assimilating tidal solutions from TOPEX/POSEIDON altimeter data into hydrodynamical model. Eight constituents (M2, S2, K1, O1, N2, P1, K2, Q1) were taken into account in each ocean tide model. Moreover, eight additional constituents (M1, J1, OO1, 2N2, Mu2, Nu2, L2, T2) can be included in NAO.99b model. Effect of ocean tides on geopotential coefficients were computed to 20th order. SLR data to Starlette and Stella were divided into arcs of 7 days length and 52 arcs (Jan. 2 - Dec. 30, 2004) were analyzed. Using different ocean tide model, orbits of these satellites were determined and weighted rms of postfit residuals are compared. We found that the NAO.99b model with 16 constituents can reduce weighted rms of postfit residuals using to the level of about 6.0 cm (Starlette) and 9.6 cm (Stella). These values are about 3-5 % smaller compared to other ocean tide models.

A daily Azores-Iceland North Atlantic Oscillation index back to 1850.

PubMed

Cropper, Thomas; Hanna, Edward; Valente, Maria Antónia; Jónsson, Trausti

2015-07-01

We present the construction of a continuous, daily (09:00 UTC), station-based (Azores-Iceland) North Atlantic Oscillation (NAO) Index back to 1871 which is extended back to 1850 with additional daily mean data. The constructed index more than doubles the length of previously existing, widely available, daily NAO time series. The index is created using entirely observational sea-level pressure (SLP) data from Iceland and 73.5% of observational SLP data from the Azores - the remainder being filled in via reanalysis (Twentieth Century Reanalysis Project and European Mean Sea Level Pressure) SLP data. Icelandic data are taken from the Southwest Iceland pressure series. We construct and document a new Ponta Delgada SLP time series based on recently digitized and newly available data that extend back to 1872. The Ponta Delgada time series is created by splicing together several fractured records (from Ponta Delgada, Lajes, and Santa Maria) and filling in the major gaps (pre-1872, 1888-1905, and 1940-1941) and occasional days (145) with reanalysis data. Further homogeneity corrections are applied to the Azores record, and the daily (09:00 UTC) NAO index is then calculated. The resulting index, with its extended temporal length and daily resolution, is the first reconstruction of daily NAO back into the 19th Century and therefore is useful for researchers across multiple disciplines.

An improvement of LLNA:DA to assess the skin sensitization potential of chemicals.

PubMed

Zhang, Hongwei; Shi, Ying; Wang, Chao; Zhao, Kangfeng; Zhang, Shaoping; Wei, Lan; Dong, Li; Gu, Wen; Xu, Yongjun; Ruan, Hongjie; Zhi, Hong; Yang, Xiaoyan

2017-01-01

We developed a modified local lymph node assay based on ATP (LLNA:DA), termed the Two-Stage LLNA:DA, to further reduce the animal numbers in the identification of sensitizers. In the Two-Stage LLNA:DA procedure, 13 chemicals ranging from non-sensitizers to extreme sensitizers were selected. The first stage used reduced LLNA:DA (rLLNA:DA) to screen out sensitive chemicals. The second stage used LLNA:DA based on OECD 442 (A) to classify those potential sensitizers screened out in the first stage. In the first stage, the SIs of the methyl methacrylate, salicylic acid, methyl salicylate, ethyl salicylate, isopropanol and propanediol were below 1.8 and need not to be tested in the second step. Others continued to be tested by LLNA:DA. In the second stage, sodium lauryl sulphate and xylene were classified as weak sensitizers. a-hexyl cinnamic aldehyde and eugenol were moderate sensitizers. Benzalkonium chloride and glyoxal were strong sensitizers, and phthalic anhydride was an extreme sensitizer. The 9/9, 11/12, 10/11, and 8/13 (positive or negative only) categories of the Two-Stage LLNA:DA were consistent with those from the other methods (LLNA, LLNA:DA, GPMT/BT and HMT/HPTA), suggesting that Two-Stage LLNA:DA have a high coincidence rate with reported data. In conclusion, The Two-Stage LLNA:DA is in line with the "3R" rules, and can be a modification of LLNA:DA but needs more study.

YangXue QingNao Wan and Silibinin Capsules, the Two Chinese Medicines, Attenuate Cognitive Impairment in Aged LDLR (+/-) Golden Syrian Hamsters Involving Protection of Blood Brain Barrier

PubMed Central

Gu, You-Yu; Huang, Ping; Li, Quan; Liu, Yu-Ying; Liu, George; Wang, Yu-Hui; Yi, Ming; Yan, Li; Wei, Xiao-Hong; Yang, Lei; Hu, Bai-He; Zhao, Xin-Rong; Chang, Xin; Sun, Kai; Pan, Chun-Shui; Cui, Yuan-Chen; Chen, Qing-Fang; Wang, Chuan-She; Fan, Jing-Yu; Ma, Zhi-Zhong; Han, Jing-Yan

2018-01-01

The purpose of the study was to explore the effect and the underlying mechanism of YangXue QingNao Wan (YXQNW) and Silibinin Capsules (SC), the two Chinese medicines, on cognitive impairment in older people with familial hyperlipidaemia. Fourteen month-old female LDLR (+/-) golden Syrian hamsters were used with their wild type as control. YXQNW (0.5 g/kg/day), SC (0.1 g/kg/day), or YXQNW (0.5 g/kg/day) + SC (0.1 g/kg/day) were administrated orally for 30 days. To assess the effects of the two drugs on plasma lipid content and cognitive ability, plasma TC, TG, LDL-C, and HDL-C were measured, and Y maze task was carried out both before and after administration. After administering of the drugs for 30 days, to evaluate the effect of the two drugs on disturbed blood flow caused by hyperlipidemia, the cerebral blood flow (CBF) was measured. To assess blood–brain barrier integrity, albumin leakage in middle cerebral artery (MCA) area was determined. To evaluate the effect of the drugs on impaired microvessels, the number and morphology of microvessels were assessed in hippocampus area. To further evaluate the ultrastructure of microvessels in hippocampus, transmission electron microscopy (TEM) and scanning electron microscopy (SEM) were carried out. To assess the profiles of claudin-5 and occludin in hippocampus, we performed immunofluorescence. Finally, to assess the expression of claudin-5, JAM-1, occludin and ZO-1 in hippocampus, western blot was carried out. The results showed that YXQNW, SC, and YXQNW + SC improved cognitive impairment of aged LDLR (+/-) golden Syrian hamsters without lowering plasma TC and LDL-C. YXQNW, SC, and YXQNW + SC attenuated albumin leakage in MCA area and neuronal damage in hippocampus, concomitant with an increase in CBF, a decrease of perivascular edema and an up-regulated expression of claudin-5, occludin and ZO-1. In conclusion, YXQNW, SC, and YXQNW + SC are able to improve cognitive ability in aged LDLR (+/-) golden Syrian hamsters

Myelin management by the 18.5–kDa and 21.5–kDa classic myelin basic protein isoforms

PubMed Central

Harauz, George; Boggs, Joan M.

2013-01-01

The classic myelin basic protein (MBP) splice isoforms range in nominal molecular mass from 14 to 21.5 kDa, and arise from the gene in the oligodendrocyte lineage (Golli) in maturing oligodendrocytes. The 18.5-kDa isoform that predominates in adult myelin adheres the cytosolic surfaces of oligodendrocyte membranes together, and forms a two-dimensional molecular sieve restricting protein diffusion into compact myelin. However, this protein has additional roles including cytoskeletal assembly and membrane extension, binding to SH3-domains, participation in Fyn-mediated signaling pathways, sequestration of phosphoinositides, and maintenance of calcium homeostasis. Of the diverse post-translational modifications of this isoform, phosphorylation is the most dynamic, and modulates 18.5-kDa MBP’s protein-membrane and protein-protein interactions, indicative of a rich repertoire of functions. In developing and mature myelin, phosphorylation can result in microdomain or even nuclear targeting of the protein, supporting the conclusion that 18.5-kDa MBP has significant roles beyond membrane adhesion. The full-length, early-developmental 21.5-kDa splice isoform is predominantly karyophilic due to a non-traditional P-Y nuclear localization signal, with effects such as promotion of oligodendrocyte proliferation. We discuss in vitro and recent in vivo evidence for multifunctionality of these classic basic proteins of myelin, and argue for a systematic evaluation of the temporal and spatial distributions of these protein isoforms, and their modified variants, during oligodendrocyte differentiation. PMID:23398367

Experience with ATLAS MySQL PanDA database service

NASA Astrophysics Data System (ADS)

Smirnov, Y.; Wlodek, T.; De, K.; Hover, J.; Ozturk, N.; Smith, J.; Wenaus, T.; Yu, D.

2010-04-01

The PanDA distributed production and analysis system has been in production use for ATLAS data processing and analysis since late 2005 in the US, and globally throughout ATLAS since early 2008. Its core architecture is based on a set of stateless web services served by Apache and backed by a suite of MySQL databases that are the repository for all PanDA information: active and archival job queues, dataset and file catalogs, site configuration information, monitoring information, system control parameters, and so on. This database system is one of the most critical components of PanDA, and has successfully delivered the functional and scaling performance required by PanDA, currently operating at a scale of half a million jobs per week, with much growth still to come. In this paper we describe the design and implementation of the PanDA database system, its architecture of MySQL servers deployed at BNL and CERN, backup strategy and monitoring tools. The system has been developed, thoroughly tested, and brought to production to provide highly reliable, scalable, flexible and available database services for ATLAS Monte Carlo production, reconstruction and physics analysis.

Technical review of the da Vinci surgical telemanipulator.

PubMed

Freschi, C; Ferrari, V; Melfi, F; Ferrari, M; Mosca, F; Cuschieri, A

2013-12-01

The da Vinci robotic surgical telemanipulator has been utilized in several surgical specialties for varied procedures, and the users' experiences have been widely published. To date, no detailed system technical analyses have been performed. A detailed review was performed of all publications and patents about the technical aspects of the da Vinci robotic system. Published technical literature on the da Vinci system highlight strengths and weaknesses of the robot design. While the system facilitates complex surgical operations and has a low malfunction rate, the lack of haptic (especially tactile) feedback and collisions between the robotic arms remain the major limitations of the system. Accurate, preplanned positioning of access ports is essential. Knowledge of the technical aspects of the da Vinci robot is important for optimal use. We confirmed the excellent system functionality and ease of use for surgeons without an engineering background. Research and development of the surgical robot has been predominant in the literature. Future trends address robot miniaturization and intelligent control design. Copyright © 2012 John Wiley & Sons, Ltd.

The missing Northern European winter cooling response to Arctic sea ice loss

PubMed Central

Screen, James A.

2017-01-01

Reductions in Arctic sea ice may promote the negative phase of the North Atlantic Oscillation (NAO−). It has been argued that NAO-related variability can be used an as analogue to predict the effects of Arctic sea ice loss on mid-latitude weather. As NAO− events are associated with colder winters over Northern Europe, a negatively shifted NAO has been proposed as a dynamical pathway for Arctic sea ice loss to cause Northern European cooling. This study uses large-ensemble atmospheric simulations with prescribed ocean surface conditions to examine how seasonal-scale NAO− events are affected by Arctic sea ice loss. Despite an intensification of NAO− events, reflected by more prevalent easterly flow, sea ice loss does not lead to Northern European winter cooling and daily cold extremes actually decrease. The dynamical cooling from the changed NAO is ‘missing', because it is offset (or exceeded) by a thermodynamical effect owing to advection of warmer air masses. PMID:28262679

The Gram-positive model organism Bacillus subtilis does not form microscopically detectable cardiolipin-specific lipid domains.

PubMed

Pogmore, Alex-Rose; Seistrup, Kenneth H; Strahl, Henrik

2018-04-01

Rather than being homogenous diffusion-dominated structures, biological membranes can exhibit areas with distinct composition and characteristics, commonly termed as lipid domains. Arguably the most comprehensively studied examples in bacteria are domains formed by cardiolipin, which have been functionally linked to protein targeting, the cell division process and the mode of action of membrane-targeting antimicrobials. Cardiolipin domains were originally identified in the Gram-negative model organism Escherichia coli based on preferential staining by the fluorescent membrane dye nonylacridine orange (NAO), and later reported to also exist in other Gram-negative and -positive bacteria. Recently, the lipid-specificity of NAO has been questioned based on studies conducted in E. coli. This prompted us to reanalyse cardiolipin domains in the Gram-positive model organism Bacillus subtilis. Here we show that logarithmically growing B. subtilis does not form microscopically detectable cardiolipin-specific lipid domains, and that NAO is not a specific stain for cardiolipin in this organism.

Inter-annual and decadal changes in teleconnections drive continental-scale synchronization of tree reproduction.

PubMed

Ascoli, Davide; Vacchiano, Giorgio; Turco, Marco; Conedera, Marco; Drobyshev, Igor; Maringer, Janet; Motta, Renzo; Hacket-Pain, Andrew

2017-12-20

Climate teleconnections drive highly variable and synchronous seed production (masting) over large scales. Disentangling the effect of high-frequency (inter-annual variation) from low-frequency (decadal trends) components of climate oscillations will improve our understanding of masting as an ecosystem process. Using century-long observations on masting (the MASTREE database) and data on the Northern Atlantic Oscillation (NAO), we show that in the last 60 years both high-frequency summer and spring NAO, and low-frequency winter NAO components are highly correlated to continent-wide masting in European beech and Norway spruce. Relationships are weaker (non-stationary) in the early twentieth century. This finding improves our understanding on how climate variation affects large-scale synchronization of tree masting. Moreover, it supports the connection between proximate and ultimate causes of masting: indeed, large-scale features of atmospheric circulation coherently drive cues and resources for masting, as well as its evolutionary drivers, such as pollination efficiency, abundance of seed dispersers, and natural disturbance regimes.

Two-thirds of global cropland area impacted by climate oscillations.

PubMed

Heino, Matias; Puma, Michael J; Ward, Philip J; Gerten, Dieter; Heck, Vera; Siebert, Stefan; Kummu, Matti

2018-03-28

The El Niño Southern Oscillation (ENSO) peaked strongly during the boreal winter 2015-2016, leading to food insecurity in many parts of Africa, Asia and Latin America. Besides ENSO, the Indian Ocean Dipole (IOD) and the North Atlantic Oscillation (NAO) are known to impact crop yields worldwide. Here we assess for the first time in a unified framework the relationships between ENSO, IOD and NAO and simulated crop productivity at the sub-country scale. Our findings reveal that during 1961-2010, crop productivity is significantly influenced by at least one large-scale climate oscillation in two-thirds of global cropland area. Besides observing new possible links, especially for NAO in Africa and the Middle East, our analyses confirm several known relationships between crop productivity and these oscillations. Our results improve the understanding of climatological crop productivity drivers, which is essential for enhancing food security in many of the most vulnerable places on the planet.

The database of the Nikolaev Astronomical Observatory as a unit of an international virtual observatory

NASA Astrophysics Data System (ADS)

Protsyuk, Yu.; Pinigin, G.; Shulga, A.

2005-06-01

Results of the development and organization of the digital database of the Nikolaev Astronomical Observatory (NAO) are presented. At present, three telescopes are connected to the local area network of NAO. All the data obtained, and results of data processing are entered into the common database of NAO. The daily average volume of new astronomical information obtained from the CCD instruments ranges from 300 MB up to 2 GB, depending on the purposes and conditions of observations. The overwhelming majority of the data are stored in the FITS format. Development and further improvement of storage standards, procedures of data handling and data processing are being carried out. It is planned to create an astronomical web portal with the possibility to have interactive access to databases and telescopes. In the future, this resource may become a part of an international virtual observatory. There are the prototypes of search tools with the use of PHP and MySQL. Efforts for getting more links to the Internet are being made.

The Relationship Between Extratropical Cyclone Steering and Blocking Along the North American East Coast

NASA Astrophysics Data System (ADS)

Booth, James F.; Dunn-Sigouin, Etienne; Pfahl, Stephan

2017-12-01

The path and speed of extratropical cyclones along the east coast of North America influence their societal impact. This work characterizes the climatological relationship between cyclone track path and speed, and blocking and the North Atlantic Oscillation (NAO). An analysis of Lagrangian cyclone track propagation speed and angle shows that the percentage of cyclones with blocks is larger for cyclones that propagate northward or southeastward, as is the size of the blocked region near the cyclone. Cyclone-centered composites show that propagation of cyclones relative to blocks is consistent with steering by the block: northward tracks more often have a block east/northeast of the cyclone; slow tracks tend to have blocks due north of the cyclone. Comparison with the NAO shows that to first-order blocking and the NAO steer cyclones in a similar manner. However, blocked cyclones are more likely to propagate northward, increasing the likelihood of cyclone related impacts.

Spatial Organization In Europe of Decadal and Interdecadal Fluctuations In Annual Rainfall

NASA Astrophysics Data System (ADS)

Lucero, O. A.; Rodriguez, N. C.

In this research the spatial patterns of decadal and bidecadal fluctuations in annual rainfall in Europe are identified. Filtering of time series of anomaly of annual rainfall is carried out using the Morlet wavelet technique. Reconstruction is achieved by sum- ming the contributions from bands of wavelet timescales; the decadal band and the bidecadal band are composed of contributions from the band of (10- to 17-year] and (17- to 27- year] timescales respectively. Results indicate that 1) the spatial organi- zation of decadal and bidecadal components of annual rainfall are standing wave-like organized patterns. Three standing decadal fluctuations zonally aligned formed the spatial pattern from 1900 until 1931; thereafter the pattern changed into a NW-SE orientation. The decadal band shows an average 12-year period. 2) The spatial orga- nization of bidecadal component was composed of three standing fluctuations since 1903 to 1986. After 1987 two standing bidecadal fluctuations were located on Europe. The orientation of bidecadal fluctuations changed during the period under study. Until 1913 the spatial pattern of the bidecadal component was zonally aligned. Since 1913 until 1986 the three bidecadal fluctuations composing the spatial pattern were aligned SW U NE; starting 1987 the spatial pattern is composed of two standing fluctuations zonally aligned. The bidecadal spatial pattern shows an average period of 20- to 22- year length. 3) At decadal and bidecadal timescales, the first principal component of the spatial field of anomaly of annual rainfall and the NAO index are connected. The upper positive third (lower negative third) of values of first principal component are indicative of extensive area with positive (negative) anomaly of annual rainfall. 4) At decadal timescale the relative phase between the first PC and the NAO index changes through the period under study; these changes define three regimes: 1) Dur- ing the regime covering the period 1900 (start of

Perfil dos Professores de Ciências Naturais do Recôncavo da Bahia - Alunos da Disciplina Terra e Universo no Curso de Ciências Naturais do Parfor

NASA Astrophysics Data System (ADS)

Lima, S. R.; Cerqueira Júnior, W.; Dutra, G.

2011-12-01

Este trabalho foi desenvolvido pelo projeto Astronomia no Recôncavo da Bahia, no Centro de Formação de Professores da Universidade Federal do Recôncavo da Bahia. Traçamos o perfil de um grupo de professores que lecionam conteúdos de Ciências Naturais no recôncavo, alunos do curso de Licenciatura em Ciências Naturais, oferecido dentro do Plano Nacional de Formação de Professores da Educação Básica. Nosso objetivo era avaliar se eles estão preparados para trabalhar conteúdos de Astronomia e identificar suas dificuldades. Os resultados serviram para orientar o professor da disciplina “Terra e Universo”, oferecida no segundo semestre de 2010. Durante a primeira aula da disciplina Terra e Universo, os alunos responderam a um questionário contendo questões abertas e fechadas, divididas em duas partes. A primeira procurando caracterizar profissionalmente os alunos enquanto professores da rede pública da região do Recôncavo Sul da Bahia e uma segunda parte procurando identificar conhecimentos básicos em Astronomia. Os resultados indicam uma predominância de professores do sexo feminino, com idade superior aos 40 anos, pardos e sem formação específica para o ensino de ciências. A maioria leciona há mais de 15 anos para turmas do 1º ao 5º ano, alguns lecionam para turmas de 6º ao 9º ano. Quase todos nunca participaram de um curso de formação continuada em Astronomia. Além disso, não estão habituados a ler revistas especializadas e nem livros com esta temática. Os que procuram ensinar temas voltados para a Astronomia têm, no livro didático, a maior fonte de informação sobre o assunto. As respostas também indicam uma deficiência em conteúdos básicos como a compreensão da esfericidade da Terra, noções de verticalidade e gravidade, incapacidade de identificar a Terra como um planeta, no Sistema Solar, em uma galáxia, no Universo. Estes resultados ressaltam a importância de disciplinas de Astronomia básica na formação dos

The Case: Bunche-Da Vinci Learning Partnership Academy

ERIC Educational Resources Information Center

Eisenberg, Nicole; Winters, Lynn; Alkin, Marvin C.

2005-01-01

The Bunche-Da Vinci case described in this article presents a situation at Bunche Elementary School that four theorists were asked to address in their evaluation designs (see EJ791771, EJ719772, EJ791773, and EJ792694). The Bunche-Da Vinci Learning Partnership Academy, an elementary school located between an urban port city and a historically…

Climate and anthropogenic factors influencing an estuarine ecosystem from NW Iberia: new high resolution multiproxy analyses from San Simón Bay (Ría de Vigo)

NASA Astrophysics Data System (ADS)

Muñoz Sobrino, Castor; García-Moreiras, Iria; Castro, Yoel; Martínez Carreño, Natalia; de Blas, Esther; Fernandez Rodríguez, Carlos; Judd, Alan; García-Gil, Soledad

2014-06-01

Two sedimentary sequences (coastal and subtidal) were studied in San Simón Bay (Ría de Vigo), situated on the Atlantic coast of NW Iberia. The coastal record is a shallowing upward sequence which evidences a locally-developed low marsh, situated below the current beach, and dated at the second half of the 4th century. During the following decades this low marsh was progressively replaced by an alder swamp which formed on it. This suggests an apparent stabilisation or slow-down of the relative sea-level (RSL), in this site, at the beginning of the Dark Ages (DA). The subtidal sequence studied reflects the main changes in the landscape, the hydrological conditions, climate and RSL affecting this part of NW Iberia during the last 1250 years. Evidence of changing dinocysts content in the sediment reveals that two centennial or decadal-scale episodes existed of shelf marine waters more intensely penetrating inside the bay: between the 15th-18th centuries and at ca 1800-1930 AD. Besides, we related different proxies with the occurrence of four main climatic stages, namely the previously described Dark Ages (DA, ca 350-750 AD), the Mediaeval Climatic Anomaly (MCA, ca 750-1100 AD) and the Little Ice Age (LIA. ca 1500-1930 AD); in addition we propose a regional MCA/LIA transition (ca 1100-1500 AD) that it has not been previously described. Our environmental characterization indicates a persistent North Atlantic Oscillation (NAO) negative mode domain in Ría de Vigo during the MCA, but this became weaker during the LIA and, probably, also during the earlier DA. NAO mode become more irregular during the MCA/LIA transition, generally persisting in dominant negative mode except for a phase of minor upwelling intensification, at ca 1150-1350 AD, which mainly affected the external parts of the ria. We postulate that an almost simultaneous phase (ca 1100-1350 AD) of stronger continental contribution in the sediments may be related to increasing storm intensities, probably linked

The Chemistry of Meteoric Metals in the Upper Atmosphere

NASA Astrophysics Data System (ADS)

Balasubramanian, Rajasekhar

The metals Na, Li, K, Ca and Fe have been observed around 90 km in the earth's upper atmosphere. Meteoric ablation is believed to be the source of these metals. The mesospheric chemistry of these metals and their impact on the general chemistry of the atmosphere are poorly understood. Therefore, a detailed investigation of processes affecting the gas -phase chemistry of these metals was undertaken. Both kinetic and photochemical studies were carried out using the techniques of pulsed photolysis of a suitable metal precursor and laser induced fluorescence of the resulting metal atoms. Ab initio calculations were also carried out to study the geometries of the metallic species and calculate their thermochemical properties. Kinetic investigations on the recombination reactions of the alkali metals with O_2 were performed over an extended temperature range (230-1100 K) in an attempt to understand their different seasonal behavior. The three reactions have very similar temperature dependences over the experimental temperature range. Use of the Troe formalism indicates that this dependency will continue into the mesospheric temperature range (140-240 K). The similarity suggests that differences in the temperature dependence of these reactions are not responsible for the different seasonal behavior of the alkali metals. The lower limits for the bond energies of the alkali superoxides were estimated from the kinetic decays obtained at 1100 K, and then combined with ab initio calculations to yield recommended bond energies. These values are of use in the Troe formalism and the mesospheric models. To assess the effectiveness of NaO_2 as a daytime sink, the absolute cross-section for photodissociation of NaO_2 was measured at 230 K. The photolysis rate of NaO_2 was derived above 70 km. The results indicate that above 85 km the reaction between NaO_2 and O is a more important loss term for NaO _2 than daytime photolysis and that between 80 and 65 km the photolysis of NaO_2 is

The future of PanDA in ATLAS distributed computing

NASA Astrophysics Data System (ADS)

De, K.; Klimentov, A.; Maeno, T.; Nilsson, P.; Oleynik, D.; Panitkin, S.; Petrosyan, A.; Schovancova, J.; Vaniachine, A.; Wenaus, T.

2015-12-01

Experiments at the Large Hadron Collider (LHC) face unprecedented computing challenges. Heterogeneous resources are distributed worldwide at hundreds of sites, thousands of physicists analyse the data remotely, the volume of processed data is beyond the exabyte scale, while data processing requires more than a few billion hours of computing usage per year. The PanDA (Production and Distributed Analysis) system was developed to meet the scale and complexity of LHC distributed computing for the ATLAS experiment. In the process, the old batch job paradigm of locally managed computing in HEP was discarded in favour of a far more automated, flexible and scalable model. The success of PanDA in ATLAS is leading to widespread adoption and testing by other experiments. PanDA is the first exascale workload management system in HEP, already operating at more than a million computing jobs per day, and processing over an exabyte of data in 2013. There are many new challenges that PanDA will face in the near future, in addition to new challenges of scale, heterogeneity and increasing user base. PanDA will need to handle rapidly changing computing infrastructure, will require factorization of code for easier deployment, will need to incorporate additional information sources including network metrics in decision making, be able to control network circuits, handle dynamically sized workload processing, provide improved visualization, and face many other challenges. In this talk we will focus on the new features, planned or recently implemented, that are relevant to the next decade of distributed computing workload management using PanDA.

ECTA/DaSy Framework Self-Assessment Comparison Tool

ERIC Educational Resources Information Center

Center for IDEA Early Childhood Data Systems (DaSy), 2016

2016-01-01

The Self-Assessment Comparison (SAC) Tool is for state Part C and Section 619/Preschool programs to use to assess changes in the implementation of one or more components of the ECTA System Framework and/or subcomponenets of the DaSy Data System Framework. It is a companion to the ECTA/DaSy Framework Self-Assessment. Key features of the SAC are…

The ATLAS PanDA Monitoring System and its Evolution

NASA Astrophysics Data System (ADS)

Klimentov, A.; Nevski, P.; Potekhin, M.; Wenaus, T.

2011-12-01

The PanDA (Production and Distributed Analysis) Workload Management System is used for ATLAS distributed production and analysis worldwide. The needs of ATLAS global computing imposed challenging requirements on the design of PanDA in areas such as scalability, robustness, automation, diagnostics, and usability for both production shifters and analysis users. Through a system-wide job database, the PanDA monitor provides a comprehensive and coherent view of the system and job execution, from high level summaries to detailed drill-down job diagnostics. It is (like the rest of PanDA) an Apache-based Python application backed by Oracle. The presentation layer is HTML code generated on the fly in the Python application which is also responsible for managing database queries. However, this approach is lacking in user interface flexibility, simplicity of communication with external systems, and ease of maintenance. A decision was therefore made to migrate the PanDA monitor server to Django Web Application Framework and apply JSON/AJAX technology in the browser front end. This allows us to greatly reduce the amount of application code, separate data preparation from presentation, leverage open source for tools such as authentication and authorization mechanisms, and provide a richer and more dynamic user experience. We describe our approach, design and initial experience with the migration process.

Evolution of the ATLAS PanDA workload management system for exascale computational science

NASA Astrophysics Data System (ADS)

Maeno, T.; De, K.; Klimentov, A.; Nilsson, P.; Oleynik, D.; Panitkin, S.; Petrosyan, A.; Schovancova, J.; Vaniachine, A.; Wenaus, T.; Yu, D.; Atlas Collaboration

2014-06-01

An important foundation underlying the impressive success of data processing and analysis in the ATLAS experiment [1] at the LHC [2] is the Production and Distributed Analysis (PanDA) workload management system [3]. PanDA was designed specifically for ATLAS and proved to be highly successful in meeting all the distributed computing needs of the experiment. However, the core design of PanDA is not experiment specific. The PanDA workload management system is capable of meeting the needs of other data intensive scientific applications. Alpha-Magnetic Spectrometer [4], an astro-particle experiment on the International Space Station, and the Compact Muon Solenoid [5], an LHC experiment, have successfully evaluated PanDA and are pursuing its adoption. In this paper, a description of the new program of work to develop a generic version of PanDA will be given, as well as the progress in extending PanDA's capabilities to support supercomputers and clouds and to leverage intelligent networking. PanDA has demonstrated at a very large scale the value of automated dynamic brokering of diverse workloads across distributed computing resources. The next generation of PanDA will allow other data-intensive sciences and a wider exascale community employing a variety of computing platforms to benefit from ATLAS' experience and proven tools.

32 CFR 643.121 - Private organizations on DA installations.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 4 2010-07-01 2010-07-01 true Private organizations on DA installations. 643.121 Section 643.121 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY... DA installations. (a) AR 210-1 defines and classifies private organizations, such as thrift shops and...

Latest Holocene Climate Variability revealed by a high-resolution multiple Proxy Record off Lisbon (Portugal)

NASA Astrophysics Data System (ADS)

Abrantes, F.; Lebreiro, S.; Ferreira, A.; Gil, I.; Jonsdottir, H.; Rodrigues, T.; Kissel, C.; Grimalt, J.

2003-04-01

The North Atlantic Oscillation (NAO) is known to have a major influence on the wintertime climate of the Atlantic basin and surrounding countries, determining precipitation and wind conditions at mid-latitudes. A comparison of Hurrel's NAO index to the mean winter (January-March) discharge of the Iberian Tagus River reveals a good negative correlation to negative NAO, while the years of largest upwelling anomalies, as referred in the literature, appear to be in good agreement with positive NAO. On this basis, a better understanding of the long-term variability of the NAO and Atlantic climate variability can be gained from high-resolution climate records from the Lisbon area. Climate variability of the last 2,000 years is assessed through a multiple proxy study of sedimentary sequences recovered from the Tagus prodelta deposition center, off Lisbon (Western Iberia). Physical properties, XRF and magnetic properties from core logging, grain size, δ18O, TOC, CaCO3, total alkenones, n-alkanes, alkenone SST, diatoms, benthic and planktonic foraminiferal assemblage compositions and fluxes are the proxies employed. The age model for site D13902 is based on AMS C-14 dates from mollusc and planktonic foraminifera shells, the reservoir correction for which was obtained by dating 3 pre-bomb, mollusc shells from the study area. Preliminary results indicate a Little Ice Age (LIA - 1300 - 1600 AD) alkenone derived SSTs around 15 degC followed by a sharp and rapid increase towards 19 degC. In spite the strong variability observed for most records, this low temperature interval is marked by a general increase in organic carbon, total alkenone concentration, diatom and foraminiferal abundances, as well as an increase in the sediment fine fraction and XRF determined Fe content, pointing to important river input and higher productivity. The Medieval Warm Period (1080 - 1300 AD) is characterized by 17-18 degC SSTs, increased mean grain size, but lower magnetic susceptibility and Fe

Sodium Octanoate Modulates the Innate Immune Response of Bovine Mammary Epithelial Cells through the TLR2/P38/JNK/ERK1/2 Pathway: Implications during Staphylococcus aureus Internalization.

PubMed

Alva-Murillo, Nayeli; Ochoa-Zarzosa, Alejandra; López-Meza, Joel E

2017-01-01

Bovine mammary epithelial cells (bMECs) contribute to mammary gland defense against invading pathogens, such as Staphylococcus aureus (intracellular facultative), which is recognized by TLR2. In a previous report, we showed that sodium octanoate [NaO, a medium chain fatty acid (C8)] induces (0.25 mM) or inhibits (1 mM) S. aureus internalization into bMECs and differentially regulates the innate immune response (IIR). However, the molecular mechanisms have not been described, which was the aim of this study. The results showed that α5β1 integrin membrane abundance (MA) was increased in 0.25 mM NaO-treated cells, but TLR2 or CD36 MA was not modified. When these receptors were blocked individually, 0.25 mM NaO-increased S. aureus internalization was notably reduced. Interestingly, in this condition, the IIR of the bMECs was impaired because MAPK (p38, JNK, and ERK1/2) phosphorylation and the activation of transcription factors related to these pathways were decreased. In addition, the 1 mM NaO treatment induced TLR2 MA, but neither the integrin nor CD36 MA was modified. The reduction in S. aureus internalization induced by 1 mM NaO was increased further when TLR2 was blocked. In addition, the phosphorylation levels of the MAPKs increased, and 13 transcriptional factors related to the IIR were slightly activated (CBF, CDP, c-Myb, AP-1, Ets-1/Pea-3, FAST-1, GAS/ISRE, AP-2, NFAT-1, OCT-1, RAR/DR-5, RXR/DR-1, and Stat-3). Moreover, the 1 mM NaO treatment up-regulated gene expression of IL-8 and RANTES and secretion of IL-1β. Notably, when 1 mM NaO-treated bMECs were challenged with S. aureus , the gene expression of IL-8 and IL-10 increased, while IL-1β secretion was reduced. In conclusion, our results showed that α5β1 integrin, TLR2 and CD36 are involved in 0.25 mM NaO-increased S. aureus internalization in bMECs. In addition, 1 mM NaO activates bMECs via the TLR2 signaling pathways (p38, JNK, and ERK1/2), which improves IIR before S. aureus invasion. Additionally

Diagnostic and Therapeutic Management of Nasal Airway Obstruction: Advances in Diagnosis and Treatment.

PubMed

Mohan, Suresh; Fuller, Jennifer C; Ford, Stephanie Friree; Lindsay, Robin W

2018-05-10

Nasal airway obstruction (NAO) is a common complaint in the otolaryngologist's office and can have a negative influence on quality of life (QOL). Existing diagnostic methods have improved, but little consensus exists on optimal tools. Furthermore, although surgical techniques for nasal obstruction continue to be developed, effective outcome measurement is lacking. An update of recent advances in diagnostic and therapeutic management of NAO is warranted. To review advances in diagnosis and treatment of NAO from the last 5 years. PubMed, Embase, CINAHL, the Cochrane Library, LILACS, Web of Science, and Guideline.gov were searched with the terms nasal obstruction and nasal blockage and their permutations from July 26, 2012, through October 23, 2017. Studies were included if they evaluated NAO using a subjective and an objective technique, and in the case of intervention-based studies, the Nasal Obstruction Symptom Evaluation (NOSE) scale and an objective technique. Exclusion criteria consisted of animal studies; patients younger than 14 years; nasal foreign bodies; nasal masses including polyps; choanal atresia; sinus disease; obstructive sleep apnea or sleep-disordered breathing; allergic rhinitis; and studies not specific to nasal obstruction. The initial search resulted in 942 articles. After independent screening by 2 investigators, 46 unique articles remained, including 2 randomized clinical trials, 3 systematic reviews, 3 meta-analyses, and 39 nonrandomized cohort studies (including a combined systematic review and meta-analysis). An aggregate of approximately 32 000 patients were reviewed (including meta-analyses). Of the subjective measures available for NAO, the NOSE scale is outstanding with regard to disease-specific validation and correlation with symptoms. No currently available objective measure can be considered a criterion standard. Structural measures of flow, pressure, and volume appear to be necessary but insufficient to assess NAO. Therefore

Use of the new da Vinci Xi® during robotic rectal resection for cancer: a pilot matched-case comparison with the da Vinci Si®.

PubMed

Morelli, Luca; Guadagni, Simone; Di Franco, Gregorio; Palmeri, Matteo; Caprili, Giovanni; D'Isidoro, Cristiano; Cobuccio, Luigi; Marciano, Emanuele; Di Candio, Giulio; Mosca, Franco

2017-03-01

The aim of this study was to compare the short-term outcomes of robotic rectal resection with total mesorectal excision (TME) for rectal cancer, with the use of the new da Vinci Xi® (Xi-RobTME group) and the da Vinci Si® (Si-RobTME group). Ten patients with histologically confirmed rectal cancer underwent robot-assisted TME with the use of the new da Vinci Xi. The outcomes of Xi-RobTME group were compared with a Si-RobTME group selected using a case-matched methodology. Overall operative times and mean hospital stays were shorter in the Xi-RobTME group. Surgeries were fully robotic with a complete take-down of the splenic flexure in all Xi-RobTME cases, while only four cases of the Si-RobTME group were fully robotic, with two cases of complete take-down of the splenic flexure. The new da Vinci Xi could offer some advantages with respect to the da Vinci Si in rectal resection for cancer. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

Impact of the North Atlantic Oscillation on the trans-Atlantic migrations of the European eel (Anguilla anguilla)

NASA Astrophysics Data System (ADS)

Kettle, A. James; Bakker, Dorothee C. E.; Haines, Keith

2008-09-01

Glass eel catches and FAO (Food and Agricultural Organization) landings of the European freshwater eel (Anguilla anguilla) show a decrease over the past 20 years. The long-term trends in the time series mask an interannual fluctuation, which becomes apparent on the application of a high-pass filter and autocorrelation analysis. Both the FAO landings and the glass eel catches show interannual fluctuations with a repeat period of 6-8 years, similar to the period of the North Atlantic Oscillation (NAO). Most glass eel catch monitoring stations are in phase. The glass eel catches show a significant negative correlation with the NAO lagged by 0-2 years, consistent with the hypothesis that the positive NAO phase has an adverse impact on the larval survival in and migration from the Sargasso Sea spawning location, one year prior to the arrival of the glass eels in Europe and North Africa. The FAO landings can be divided into two groups of different phase that have an approximate correspondence to the NAO dipole in winter rainfall in Europe and North Africa. One group (P) comprises Denmark, Ireland, Morocco, Netherlands, Norway, Sweden, Tunisia, and the United Kingdom, and the other group (N) comprises France, Germany, Italy, Poland, Portugal, Spain, and Turkey. At least for the interannual fluctuations, the success of the glass eel fishery (and eel recruitment) may be coupled with the number of migrating silver eels from the N group of countries and uncoupled with the P group of countries.

A 32 kDa viral attachment protein of lymphocystis disease virus (LCDV) specifically interacts with a 27.8 kDa cellular receptor from flounder (Paralichthys olivaceus).

PubMed

Zhong, Ying; Fei, Chenjie; Tang, Xiaoqian; Zhan, Wenbin; Sheng, Xiuzhen

2017-06-01

The 27.8 kDa protein in flounder gill (FG) cells was previously proved to be a receptor specific for lymphocystis disease virus (LCDV) entry and infection. In this paper, a 32 kDa viral attachment protein (VAP) of LCDV specifically binding to the 27.8 kDa receptor (27.8R) was found by far-Western blotting coupled with monoclonal antibodies (MAbs) against 27.8R. The 32 kDa protein was confirmed to be encoded by the open reading frame (ORF) 038 gene in LCDV-C, and predicted to contain a putative transmembrane region, multiple N-myristoylation and glycosylation sites and phosphorylation motifs. The expression plasmid of pET-32a-ORF038 was constructed and the recombinant VAP (rVAP) was obtained. Rabbit polyclonal antibodies against the rVAP were prepared and could recognize the rVAP and 32 kDa protein in LCDV. Immunogold electron microscopy showed that the 32 kDa protein was located on the surface of LCDV particles. Immunofluorescence assay demonstrated that the rVAP could bind to the 27.8R on the cell membrane of the FG monolayer and the anti-27.8R MAbs could block the rVAP binding. Pre-incubation of the rVAP with FG cells before LCDV infection, or pre-incubation of LCDV with the antibodies against the rVAP, could significantly decrease the LCDV copy numbers (P<0.05) and delay the emergence of cytopathic effects in FG cells in a dose-dependent manner. These results indicated for the first time that the 32 kDa protein functioned as an attachment protein for the initial attachment and entry of LCDV, and the interaction of the 32 kDa VAP with the 27.8R-initiated LCDV infection.

Virtual reality training improves da Vinci performance: a prospective trial.

PubMed

Cho, Jae Sung; Hahn, Koo Yong; Kwak, Jung Myun; Kim, Jin; Baek, Se Jin; Shin, Jae Won; Kim, Seon Hahn

2013-12-01

The DV-Trainer™ (a virtual reality [VR] simulator) (Mimic Technologies, Inc., Seattle, WA) is one of several different robotic surgical training methods. We designed a prospective study to determine whether VR training could improve da Vinci(®) Surgical System (Intuitive Surgical, Inc., Sunnyvale, CA) performance. Surgeons (n=12) were enrolled using a randomized protocol. Groups 1 (VR training) and 2 (control) participated in VR and da Vinci exercises. Participants' time and moving distance were combined to determine a composite score: VR index=1000/(time×moving distance). The da Vinci exercises included needle control and suturing. Procedure time and error were measured. A composite index (DV index) was computed and used to measure da Vinci competency. After the initial trial with both the VR and da Vinci exercises, only Group 1 was trained with the VR simulator following our institutional curriculum for 3 weeks. All members of both groups then participated in the second trial of the VR and da Vinci exercises and were scored in the same way as in the initial trial. In the initial trial, there was no difference in the VR index (Group 1 versus Group 2, 8.9 ± 3.3 versus 9.4 ± 3.7; P=.832) and the DV index (Group 1 versus Group 2, 3.85 ± 0.73 versus 3.66 ± 0.65; P=.584) scores between the two groups. At the second time point, Group 1 showed increased VR index scores in comparison with Group 2 (19.3 ± 4.5 versus 9.7 ± 4.1, respectively; P=.001) and improved da Vinci performance skills as measured by the DV index (5.80 ± 1.13 versus 4.05 ± 1.03, respectively; P=.028) and by suturing time (7.1 ± 1.54 minutes versus 10.55 ± 1.93 minutes, respectively; P=.018). We found that VR simulator training can improve da Vinci performance. VR practice can result in an early plateau in the learning curve for robotic practice under controlled circumstances.

The ATLAS PanDA Pilot in Operation

NASA Astrophysics Data System (ADS)

Nilsson, P.; Caballero, J.; De, K.; Maeno, T.; Stradling, A.; Wenaus, T.; ATLAS Collaboration

2011-12-01

The Production and Distributed Analysis system (PanDA) [1-2] was designed to meet ATLAS [3] requirements for a data-driven workload management system capable of operating at LHC data processing scale. Submitted jobs are executed on worker nodes by pilot jobs sent to the grid sites by pilot factories. This paper provides an overview of the PanDA pilot [4] system and presents major features added in light of recent operational experience, including multi-job processing, advanced job recovery for jobs with output storage failures, gLExec [5-6] based identity switching from the generic pilot to the actual user, and other security measures. The PanDA system serves all ATLAS distributed processing and is the primary system for distributed analysis; it is currently used at over 100 sites worldwide. We analyze the performance of the pilot system in processing real LHC data on the OSG [7], EGI [8] and Nordugrid [9-10] infrastructures used by ATLAS, and describe plans for its evolution.

Yarkovsky-driven Impact Predictions: Apophis and 1950 DA

NASA Astrophysics Data System (ADS)

Chesley, Steven R.; Farnocchia, D.; Chodas, P. W.; Milani, A.

2013-10-01

Orbit determination for Near-Earth Asteroids presents unique technical challenges due to the imperative of early detection and careful assessment of the risk posed by specific Earth close approaches. The occurrence of an Earth impact can be decisively driven by the Yarkovsky effect, which is the most important nongravitational perturbation as it causes asteroids to undergo a secular variation in semimajor axis resulting in a quadratic effect in anomaly. We discuss the cases of (99942) Apophis and (29075) 1950 DA. The relevance of the Yarkovsky effect for Apophis is due to a scattering close approach in 2029 with minimum geocentric distance ~38000 km. For 1950 DA the influence of the Yarkovsky effect in 2880 is due to the long time interval preceding the impact. We use the available information from the astrometry and the asteroids' physical models and dynamical evolution as a starting point for a Monte Carlo method that allows us to measure how the Yarkovsky effect affects orbital predictions. We also find that 1950 DA has a 98% likelihood of being a retrograde rotator. For Apophis we map onto the 2029 close approach b-plane and analyze the keyholes corresponding to resonant close approaches. For 1950 DA we use the b-plane corresponding to the possible impact in 2880. We finally compute the impact probability from the mapped probability density function on the considered b-plane. For Apophis we have 4 in a million chances of an impact in 2068, while the probability of Earth impact in 2880 for 1950 DA is 0.04%.

Da Vinci robot-assisted system for thymectomy: experience of 55 patients in China.

PubMed

Jun, Yi; Hao, Li; Demin, Li; Guohua, Dong; Hua, Jing; Yi, Shen

2014-09-01

Da Vinci robot-assisted thymectomy has been used in the past several years in China, however, practical experience in performing this approach in China remains limited. Thus, the study aimed to evaluate the experience of da Vinci robot-assisted thymectomy in China. From June 2010 to December 2012, 55 patients with diseases of the thymus underwent thymectomy using the da Vinci surgical HD robotic system. The clinical data of the da Vinci robot-assisted thymectomies were compared with the data of video-assisted thoracoscopic thymectomies in the same period. All da Vinci robot operations were successful. This is a retrospective analysis which demonstrated that compared with video-assisted thoracoscopic thymectomy in the same period, the clinical outcomes of da Vinci robot-assisted thymectomy were not significantly different. The da Vinci robot-assisted thymectomy is a safe, minimally invasive, and convenient operation, and shows promise for general thoracic surgery in China. Copyright © 2014 John Wiley & Sons, Ltd.

JCoDA: a tool for detecting evolutionary selection.

PubMed

Steinway, Steven N; Dannenfelser, Ruth; Laucius, Christopher D; Hayes, James E; Nayak, Sudhir

2010-05-27

The incorporation of annotated sequence information from multiple related species in commonly used databases (Ensembl, Flybase, Saccharomyces Genome Database, Wormbase, etc.) has increased dramatically over the last few years. This influx of information has provided a considerable amount of raw material for evaluation of evolutionary relationships. To aid in the process, we have developed JCoDA (Java Codon Delimited Alignment) as a simple-to-use visualization tool for the detection of site specific and regional positive/negative evolutionary selection amongst homologous coding sequences. JCoDA accepts user-inputted unaligned or pre-aligned coding sequences, performs a codon-delimited alignment using ClustalW, and determines the dN/dS calculations using PAML (Phylogenetic Analysis Using Maximum Likelihood, yn00 and codeml) in order to identify regions and sites under evolutionary selection. The JCoDA package includes a graphical interface for Phylip (Phylogeny Inference Package) to generate phylogenetic trees, manages formatting of all required file types, and streamlines passage of information between underlying programs. The raw data are output to user configurable graphs with sliding window options for straightforward visualization of pairwise or gene family comparisons. Additionally, codon-delimited alignments are output in a variety of common formats and all dN/dS calculations can be output in comma-separated value (CSV) format for downstream analysis. To illustrate the types of analyses that are facilitated by JCoDA, we have taken advantage of the well studied sex determination pathway in nematodes as well as the extensive sequence information available to identify genes under positive selection, examples of regional positive selection, and differences in selection based on the role of genes in the sex determination pathway. JCoDA is a configurable, open source, user-friendly visualization tool for performing evolutionary analysis on homologous coding

JCoDA: a tool for detecting evolutionary selection

PubMed Central

2010-01-01

Background The incorporation of annotated sequence information from multiple related species in commonly used databases (Ensembl, Flybase, Saccharomyces Genome Database, Wormbase, etc.) has increased dramatically over the last few years. This influx of information has provided a considerable amount of raw material for evaluation of evolutionary relationships. To aid in the process, we have developed JCoDA (Java Codon Delimited Alignment) as a simple-to-use visualization tool for the detection of site specific and regional positive/negative evolutionary selection amongst homologous coding sequences. Results JCoDA accepts user-inputted unaligned or pre-aligned coding sequences, performs a codon-delimited alignment using ClustalW, and determines the dN/dS calculations using PAML (Phylogenetic Analysis Using Maximum Likelihood, yn00 and codeml) in order to identify regions and sites under evolutionary selection. The JCoDA package includes a graphical interface for Phylip (Phylogeny Inference Package) to generate phylogenetic trees, manages formatting of all required file types, and streamlines passage of information between underlying programs. The raw data are output to user configurable graphs with sliding window options for straightforward visualization of pairwise or gene family comparisons. Additionally, codon-delimited alignments are output in a variety of common formats and all dN/dS calculations can be output in comma-separated value (CSV) format for downstream analysis. To illustrate the types of analyses that are facilitated by JCoDA, we have taken advantage of the well studied sex determination pathway in nematodes as well as the extensive sequence information available to identify genes under positive selection, examples of regional positive selection, and differences in selection based on the role of genes in the sex determination pathway. Conclusions JCoDA is a configurable, open source, user-friendly visualization tool for performing evolutionary

Kinetic properties of the sodium-calcium exchanger in rat brain synaptosomes.

PubMed Central

Fontana, G; Rogowski, R S; Blaustein, M P

1995-01-01

1. The kinetic properties of the internal Na+ (Na+i)- dependent 45Ca2+ influx and external Na+ (Na+o)-dependent 45Ca2+ efflux were determined in isolated rat brain nerve terminals (synaptosomes) under conditions which the concentrations of internal Na+ ([Na+]i), external Na+ ([Na+]o), external Ca2+ (Ca2+]o), and external K+ ([K+]o) were varied. Both fluxes are manifestations of Na(+)-Ca2+ exchange. 2. Ca2+ uptake was augmented by raising [Na+]i and / or lowering [Na+]o. The increase in Ca2+ uptake induced by removing external Na+ was, in most instances, quantitatively equal to the Na+i-dependent Ca2+ uptake. 3. The Na+i-dependent Ca2+ uptake (measured at 1 s) was activated with an apparent half-maximal [Ca2+]o (KCa(o)) of about 0.23 mM. External Na+ inhibited the uptake in a non- competitive manner: increasing [Na+]o from 4.7 to 96 mM reduced the maximal Na+(i)-dependent Ca2+ uptake but did not affect KCa(o). 4. The inhibition of Ca2+ uptake by Na+o was proportional to ([Na+]o)2, and had a Hill coefficient (nH) of approximately 2.0. The mean apparent half-maximal [Na+]o for inhibition (KI(Na)) was about 60mM, and was independent of [Ca2+]o between 0.1 and 1.2mM; this, too, is indicative of non-competitive inhibition. 5. Low concentrations of alkali metal ions (M+) in the medium, including Na+, stimulated the Na+i-dependent uptake. The external Na+ and K+ concentrations required for apparent half-maximal activation (KM(Na) and KM(K), respectively) were 0.12 and 0.10mM. Thus, the relationship between Ca2+ uptake and [Na+]o was biphasic: uptake was stimulated by [Na+]o < or = 10 mM, and inhibited by higher [Na+]o. 6. The calculated maximal Na+i-dependent Ca2+ uptake (Jmax) was about 1530 pmol (mg protein) -1s-1 at 30 degrees C saturating [Ca2+]o and external M+ concentration ([M+]o), and with negligible inhibition by external Na+. 7. Internal Na+ activated the Ca2+ uptake with an apparent half-maximal concentration (KNa(i)) of about 20 mM and a Hill coefficient, n

High resolution structure of cleaved Serpin 42 Da from Drosophila melanogaster.

PubMed

Ellisdon, Andrew M; Zhang, Qingwei; Henstridge, Michelle A; Johnson, Travis K; Warr, Coral G; Law, Ruby Hp; Whisstock, James C

2014-04-24

The Drosophila melanogaster Serpin 42 Da gene (previously Serpin 4) encodes a serine protease inhibitor that is capable of remarkable functional diversity through the alternative splicing of four different reactive centre loop exons. Eight protein isoforms of Serpin 42 Da have been identified to date, targeting the protease inhibitor to both different proteases and cellular locations. Biochemical and genetic studies suggest that Serpin 42 Da inhibits target proteases through the classical serpin 'suicide' inhibition mechanism, however the crystal structure of a representative Serpin 42 Da isoform remains to be determined. We report two high-resolution crystal structures of Serpin 42 Da representing the A/B isoforms in the cleaved conformation, belonging to two different space-groups and diffracting to 1.7 Å and 1.8 Å. Structural analysis reveals the archetypal serpin fold, with the major elements of secondary structure displaying significant homology to the vertebrate serpin, neuroserpin. Key residues known to have central roles in the serpin inhibitory mechanism are conserved in both the hinge and shutter regions of Serpin 42 Da. Furthermore, these structures identify important conserved interactions that appear to be of crucial importance in allowing the Serpin 42 Da fold to act as a versatile template for multiple reactive centre loops that have different sequences and protease specificities. In combination with previous biochemical and genetic studies, these structures confirm for the first time that the Serpin 42 Da isoforms are typical inhibitory serpin family members with the conserved serpin fold and inhibitory mechanism. Additionally, these data reveal the remarkable structural plasticity of serpins, whereby the basic fold is harnessed as a template for inhibition of a large spectrum of proteases by reactive centre loop exon 'switching'. This is the first structure of a Drosophila serpin reported to date, and will provide a platform for future mutational

Long-term Variations of The Solar Activity -- Lower Atmosphere Relationship

NASA Astrophysics Data System (ADS)

Zaitseva, S.; Akhremtchik, S.; Pudovkin, M.; Besser, B.; Rijnbeek, R.

Long-term variations of the air temperature in St.Petersburg, Stockholm, Salzburg and English Midlands are considered. There is shown that in the regions under consider- ation the air temperature distinctly depends on the intensity of the lower atmospheric zonal circulation (Blinova index and North Atlantic Oscillation index (NAO)). In turn, the NAO-index is shown to depend on the solar activity. However, this dependence is rather complicated and exhibits long-period variations associated with secular varia- tions of the solar activity. A possible mechanism of this phenomena is discussed.

Winter NH low-frequency variability in a hierarchy of low-order stochastic dynamical models of earth-atmosphere system

NASA Astrophysics Data System (ADS)

Zhao, Nan

2018-02-01

The origin of winter Northern Hemispheric low-frequency variability (hereafter, LFV) is regarded to be related to the coupled earth-atmosphere system characterized by the interaction of the jet stream with mid-latitude mountain ranges. On the other hand, observed LFV usually appears as transitions among multiple planetary-scale flow regimes of Northern Hemisphere like NAO + , AO +, AO - and NAO - . Moreover, the interaction between synoptic-scale eddies and the planetary-scale disturbance is also inevitable in the origin of LFV. These raise a question regarding how to incorporate all these aspects into just one framework to demonstrate (1) a planetary-scale dynamics of interaction of the jet stream with mid-latitude mountain ranges can really produce LFV, (2) such a dynamics can be responsible for the existence of above multiple flow regimes, and (3) the role of interaction with eddy is also clarified. For this purpose, a hierarchy of low-order stochastic dynamical models of the coupled earth-atmosphere system derived empirically from different timescale ranges of indices of Arctic Oscillation (AO), North Atlantic Oscillation (NAO), Pacific/North American (PNA), and length of day (LOD) and related probability density function (PDF) analysis are employed in this study. The results seem to suggest that the origin of LFV cannot be understood completely within the planetary-scale dynamics of the interaction of the jet stream with mid-latitude mountain ranges, because (1) the existence of multiple flow regimes such as NAO+, AO+, AO- and NAO- resulted from processes with timescales much longer than LFV itself, which may have underlying dynamics other than topography-jet stream interaction, and (2) we find LFV seems not necessarily to come directly from the planetary-scale dynamics of the interaction of the jet stream with mid-latitude mountain, although it can produce similar oscillatory behavior. The feedback/forcing of synoptic-scale eddies on the planetary

Qual o Papel da Escola e da Mídia na Obtenção dos Conhecimentos Astronômicos?

NASA Astrophysics Data System (ADS)

da Cunha, W. S.; Voelzke, M. R.; Amaral, L. H.

2007-08-01

É amplamente reconhecido que as pessoas em geral têm grande fascínio e interesse pela Astronomia. Por outro lado, o conteúdo dessa área incluído no ensino formal está longe de ser abrangente e suficiente para suprir a demanda. Esse interesse permite aperfeiçoar a divulgação e o ensino não formal de Astronomia através da mídia aliando a adequação do conteúdo à expectativa das pessoas. A reforma do Currículo Básico da Escola Pública da maioria dos Estados brasileiros tem introduzido Astronomia desde a pré-escola até o Ensino Médio. Num estudo realizado com 1180 alunos do Ensino Médio de seis escolas estaduais, revelou-se através da aplicação de um formulário contendo questões que abordavam conhecimentos básicos em Astronomia, como foram adquiridos tais conhecimentos e à infra-estrutura da escola. Para 66,1% dos entrevistados o professor já fez alguma apresentação a respeito de Astronomia. O presente estudo revelou também que 54,4% dos alunos entrevistados adquiriram seus conhecimentos astronômicos na escola, 18,4% através da televisão e 27,1% afirmaram que seus conhecimentos foram obtidos através de outros tipos de mídia (internet, livros didáticos, filmes e revistas). Embora o estudo revele claramente que há certo equilíbrio no meio em que os alunos obtiveram seus conhecimentos astronômicos, a mídia busca não somente sua difusão, mas a disponibilização desse conhecimento de maneira correta, que às vezes, não é atingido, apresentando conceitos sem fundamentação e incorretos. Por outro lado, no dia-a-dia escolar, é comum encontrar professores que vêm para as aulas com concepções prévias, que podem diferir substancialmente das idéias a serem ensinadas, dificultando o aprendizado de futuros conceitos científicos. Uma avaliação criteriosa, avaliando as dificuldades dos professores em determinar o sentido correto dos conceitos e observando a metodologia que utilizam no ensino, poderá proporcionar uma melhor

The Effect of DA-9701 in Opioid-induced Bowel Dysfunction of Guinea Pig.

PubMed

Hussain, Zahid; Rhee, Kwang Won; Lee, Young Ju; Park, Hyojin

2016-07-30

Opioid induced bowel dysfunction (OIBD) is associated with decreased gastrointestinal (GI) propulsive activity due to intake of opioid analgesics. DA-9701, a novel prokinetic agent formulated with Pharbitis Semen and Corydalis Tuber has promising effects on GI motor function. Therefore, we aim to evaluate the prokinetic effects of DA-9701 in an OIBD model of guinea pig. The ileal and distal colon muscle contraction in presence of different doses of DA-9701, morphine, and combination (morphine + DA-9701) was measured by tissue bath study. The prokinetic effect of DA-9701 was assessed by charcoal transit and fecal pellet output assay in an OIBD model of guinea pig. DA-9701 significantly increased the amplitude and area under the curve of ileal muscle contraction, while there was insignificant effect on the distal colon compared to the control. The maximal amplitude of ileal muscle contraction was acquired at a concentration of 10 μg/mL of DA-9701. In contrast, morphine significantly decreased the amplitude of ileal and distal colon muscle contraction compared to the control. Morphine delayed both upper (P < 0.01) and lower (P < 0.05) GI transit, and delayed GI transit was restored by the administration of DA-9701. Morphine induced reduction of contractility was significantly ameliorated by addition of DA-9701 in both ileal and distal colon muscles. DA-9701 significantly increased the amplitude of contraction of the ileal muscle, however the distal colon muscle contraction was insignificant. Additionally, it restored delayed upper and lower GI transit in an OIBD model of guinea pig, and it might prove to be a useful candidate drug in a clinical trial for OIBD.

Endogenous dopamine (DA) modulates (3H)spiperone binding in vivo in rat brain

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bischoff, S.; Krauss, J.; Grunenwald, C.

1991-01-01

(3H)spiperone (SPI) binding in vivo, biochemical parameters and behavior were measured after modulating DA levels by various drug treatments. DA releasers and uptake inhibitors increased SPI binding in rat striatum. In other brain areas, the effects were variable, but only the pituitary remained unaffected. Surprisingly, nomifensine decreased SPI binding in frontal cortex. The effects of these drugs were monitored by measuring DA, serotonin (5-HT) and their metabolites in the same rats. The increased SPI binding in striatum was parallel to the locomotor stimulation with the following rank order: amfonelic acid greater than nomifensine greater than D-amphetamine greater than or equalmore » to methylphenidate greater than amineptine greater than bupropion. Decreasing DA levels with reserpine or alpha-methyl-para-tyrosine reduced SPI binding by 45% in striatum only when both drugs were combined. In contrast, reserpine enhanced SPI binding in pituitary. Thus, the amount of releasable DA seems to modulate SPI binding characteristics. It is suggested that in vivo, DA receptors are submitted to dynamic regulation in response to changes in intrasynaptic concentrations of DA.« less

Contribution of DA Signaling to Appetitive Odor Perception in a Drosophila Model.

PubMed

Pu, Yuhan; Palombo, Melissa Megan Masserant; Shen, Ping

2018-04-13

Understanding cognitive processes that translate chemically diverse olfactory stimuli to specific appetitive drives remains challenging. We have shown that food-related odors arouse impulsive-like feeding of food media that are palatable and readily accessible in well-nourished Drosophila larvae. Here we provide evidence that two assemblies of four dopamine (DA) neurons, one per brain hemisphere, contribute to perceptual processing of the qualitative and quantitative attributes of food scents. These DA neurons receive neural representations of chemically diverse food-related odors, and their combined neuronal activities become increasingly important as the chemical complexity of an appetizing odor stimulus increases. Furthermore, in each assembly of DA neurons, integrated odor signals are transformed to one-dimensional DA outputs that have no intrinsic reward values. Finally, a genetic analysis has revealed a D1-type DA receptor (Dop1R1)-gated mechanism in neuropeptide Y-like neurons that assigns appetitive significance to selected DA outputs. Our findings suggest that fly larvae provide a useful platform for elucidation of molecular and circuit mechanisms underlying cognitive processing of olfactory and possibly other sensory cues.

PanDA for COMPASS at JINR

NASA Astrophysics Data System (ADS)

Petrosyan, A. Sh.

2016-09-01

PanDA (Production and Distributed Analysis System) is a workload management system, widely used for data processing at experiments on Large Hadron Collider and others. COMPASS is a high-energy physics experiment at the Super Proton Synchrotron. Data processing for COMPASS runs locally at CERN, on lxbatch, the data itself stored in CASTOR. In 2014 an idea to start running COMPASS production through PanDA arose. Such transformation in experiment's data processing will allow COMPASS community to use not only CERN resources, but also Grid resources worldwide. During the spring and summer of 2015 installation, validation and migration work is being performed at JINR. Details and results of this process are presented in this paper.

DA-9801 promotes neurite outgrowth via ERK1/2-CREB pathway in PC12 cells.

PubMed

Won, Jong Hoon; Ahn, Kyong Hoon; Back, Moon Jung; Ha, Hae Chan; Jang, Ji Min; Kim, Ha Hyung; Choi, Sang-Zin; Son, Miwon; Kim, Dae Kyong

2015-01-01

In the present study, we examined the mechanisms underlying the effect of DA-9801 on neurite outgrowth. We found that DA-9801 elicits its effects via the mitogen-activated protein kinase (MEK) extracellular signal-regulated kinase (ERK)1/2-cAMP response element-binding protein (CREB) pathway. DA-9801, an extract from a mixture of Dioscorea japonica and Dioscorea nipponica, was reported to promote neurite outgrowth in PC12 cells. The effects of DA-9801 on cell viability and expression of neuronal markers were evaluated in PC12 cells. To investigate DA-9801 action, specific inhibitors targeting the ERK signaling cascade were used. No cytotoxicity was observed in PC12 cells at DA-9801 concentrations of less than 30 µg/mL. In the presence of nerve growth factor (NGF, 2 ng/mL), DA-9801 promoted neurite outgrowth and increased the relative mRNA levels of neurofilament-L (NF-L), a marker of neuronal differentiation. The Raf-1 inhibitor GW5074 and MEK inhibitor PD98059 significantly attenuated DA-9801-induced neurite outgrowth. Additionally, the MEK1 and MEK2 inhibitor SL327 significantly attenuated the increase in the percentage of neurite-bearing PC12 cells induced by DA-9801 treatment. Conversely, the selective p38 mitogen-activated protein kinase inhibitor SB203580 did not attenuate the DA-9801 treatment-induced increase in the percentage of neurite-bearing PC12 cells. DA-9801 enhanced the phosphorylation of ERK1/2 and CREB in PC12 cells incubated with and without NGF. Pretreatment with PD98059 blocked the DA-9801-induced phosphorylation of ERK1/2 and CREB. In conclusion, DA-9801 induces neurite outgrowth by affecting the ERK1/2-CREB signaling pathway. Insights into the mechanism underlying this effect of DA-9801 may suggest novel potential strategies for the treatment of peripheral neuropathy.

Multiquadrant robotic colorectal surgery: the da Vinci Xi vs Si comparison.

PubMed

Protyniak, Bogdan; Jorden, Jeffrey; Farmer, Russell

2018-03-01

The newly introduced da Vinci Xi Surgical System hopes to address the shortcomings of its predecessor, specifically robotic arm restrictions and difficulty working in multiple quadrants. We compare the two robot platforms in multiquadrant surgery at a major colorectal referral center. Forty-four patients in the da Vinci Si group and 26 patients in the Xi group underwent sigmoidectomy or low anterior resection between 2014 and 2016. Patient demographics, operative variables, and postoperative outcomes were compared using descriptive statistics. Both groups were similar in age, sex, BMI, pelvic surgeries, and ASA class. Splenic flexure was mobilized in more (p = 0.045) da Vinci Xi cases compared to da Vinci Si both for sigmoidectomy (50 vs 15.4%) and low anterior resection (60 vs 29%). There was no significant difference in operative time (219.9 vs 224.7 min; p = 0.640), blood loss (170.0 vs 188.1 mL; p = 0.289), length of stay (5.7 vs 6 days; p = 0.851), or overall complications (26.9 vs 22.7%; p = 0.692) between the da Vinci Xi and Si groups, respectively. Single-dock multiquadrant robotic surgery, measured by splenic flexure mobilization with concomitant pelvic dissection, was more frequently performed using the da Vinci Xi platform with no increase in operative time, bleeding, or postoperative complications. The new platform provides surgeons an easier alternative to the da Vinci Si dual docking or combined robotic/laparoscopic multiquadrant surgery.

Output control of da Vinci surgical system's surgical graspers.

PubMed

Johnson, Paul J; Schmidt, David E; Duvvuri, Umamaheswar

2014-01-01

The number of robot-assisted surgeries performed with the da Vinci surgical system has increased significantly over the past decade. The articulating movements of the robotic surgical grasper are controlled by grip controls at the master console. The user interface has been implicated as one contributing factor in surgical grasping errors. The goal of our study was to characterize and evaluate the user interface of the da Vinci surgical system in controlling surgical graspers. An angular manipulator with force sensors was used to increment the grip control angle as grasper output angles were measured. Input force at the grip control was simultaneously measured throughout the range of motion. Pressure film was used to assess the maximum grasping force achievable with the endoscopic grasping tool. The da Vinci robot's grip control angular input has a nonproportional relationship with the grasper instrument output. The grip control mechanism presents an intrinsic resistant force to the surgeon's fingertips and provides no haptic feedback. The da Vinci Maryland graspers are capable of applying up to 5.1 MPa of local pressure. The angular and force input at the grip control of the da Vinci robot's surgical graspers is nonproportional to the grasper instrument's output. Understanding the true relationship of the grip control input to grasper instrument output may help surgeons understand how to better control the surgical graspers and promote fewer grasping errors. Copyright © 2014 Elsevier Inc. All rights reserved.

Laser fluorescence studies of the chemical interactions of sodium species with sulfur bearing fuels

NASA Technical Reports Server (NTRS)

Steinberg, M.; Schofield, K.

1983-01-01

By using a large matrix of fuel rich and fuel lean H2/O2/N2 and fuel rich C2H2/O2/N2 flames, the behavior of sodium and its interactions with sulfur at high temperatures was extensively characterized. OH concentrations were measured for each flame using the previously validated laser induced fluorescence technique. Sodium atomic concentrations were obtained by the saturated laser fluorescence method. Measurements were made in the absence and presence of up to 2% sulfur. In oxygen rich systems sodium is depleted by NaO2 and NaOH formation. The relative amounts of each are controlled by the degree of nonequilibration of the flame radicals and by the temperature. The bond strength of NaO2 was established. For the first time, a complete understanding of the complex behavior of sodium in fuel lean H2/O2 flames has emerged and computer modeling has permitted various rate constants of Na, NaO2 and NaOH reactions to be approximately fixed.

Mevalocidin: a novel, phloem mobile phytotoxin from Fusarium DA056446 and Rosellinia DA092917.

PubMed

Gerwick, B Clifford; Brewster, William K; Deboer, Gerrit J; Fields, Steve C; Graupner, Paul R; Hahn, Donald R; Pearce, Cedric J; Schmitzer, Paul R; Webster, Jeffery D

2013-02-01

A multiyear effort to identify new natural products was built on a hypothesis that both phytotoxins from plant pathogens and antimicrobial compounds might demonstrate herbicidal activity. The discovery of one such compound, mevalocidin, is described in the current report. Mevalocidin was discovered from static cultures of two unrelated fungal isolates designated Rosellinia DA092917 and Fusarium DA056446. The chemical structure was confirmed by independent synthesis. Mevalocidin demonstrated broad spectrum post-emergence activity on grasses and broadleaves and produced a unique set of visual symptoms on treated plants suggesting a novel mode of action. Mevalocidin was rapidly absorbed in a representative grass and broadleaf plant. Translocation occurred from the treated leaf to other plant parts including roots confirming phloem as well as xylem mobility. By 24 hr after application, over 20 % had been redistributed through-out the plant. Mevalocidin is a unique phytotoxin based on its chemistry, with the uncommon attribute of demonstrating both xylem and phloem mobility in grass and broadleaf plants.

Da Vinci Xi Robot–Assisted Penetrating Keratoplasty

PubMed Central

Chammas, Jimmy; Sauer, Arnaud; Pizzuto, Joëlle; Pouthier, Fabienne; Gaucher, David; Marescaux, Jacques; Mutter, Didier; Bourcier, Tristan

2017-01-01

Purpose This study aims (1) to investigate the feasibility of robot-assisted penetrating keratoplasty (PK) using the new Da Vinci Xi Surgical System and (2) to report what we believe to be the first use of this system in experimental eye surgery. Methods Robot-assisted PK procedures were performed on human corneal transplants using the Da Vinci Xi Surgical System. After an 8-mm corneal trephination, four interrupted sutures and one 10.0 monofilament running suture were made. For each procedure, duration and successful completion of the surgery as well as any unexpected events were assessed. The depth of the corneal sutures was checked postoperatively using spectral-domain optical coherence tomography (SD-OCT). Results Robot-assisted PK was successfully performed on 12 corneas. The Da Vinci Xi Surgical System provided the necessary dexterity to perform the different steps of surgery. The mean duration of the procedures was 43.4 ± 8.9 minutes (range: 28.5–61.1 minutes). There were no unexpected intraoperative events. SD-OCT confirmed that the sutures were placed at the appropriate depth. Conclusions We confirm the feasibility of robot-assisted PK with the new Da Vinci Surgical System and report the first use of the Xi model in experimental eye surgery. Operative time of robot-assisted PK surgery is now close to that of conventional manual surgery due to both improvement of the optical system and the presence of microsurgical instruments. Translational Relevance Experimentations will allow the advantages of robot-assisted microsurgery to be identified while underlining the improvements and innovations necessary for clinical use. PMID:28660096

Da Vinci Xi Robot-Assisted Penetrating Keratoplasty.

PubMed

Chammas, Jimmy; Sauer, Arnaud; Pizzuto, Joëlle; Pouthier, Fabienne; Gaucher, David; Marescaux, Jacques; Mutter, Didier; Bourcier, Tristan

2017-06-01

This study aims (1) to investigate the feasibility of robot-assisted penetrating keratoplasty (PK) using the new Da Vinci Xi Surgical System and (2) to report what we believe to be the first use of this system in experimental eye surgery. Robot-assisted PK procedures were performed on human corneal transplants using the Da Vinci Xi Surgical System. After an 8-mm corneal trephination, four interrupted sutures and one 10.0 monofilament running suture were made. For each procedure, duration and successful completion of the surgery as well as any unexpected events were assessed. The depth of the corneal sutures was checked postoperatively using spectral-domain optical coherence tomography (SD-OCT). Robot-assisted PK was successfully performed on 12 corneas. The Da Vinci Xi Surgical System provided the necessary dexterity to perform the different steps of surgery. The mean duration of the procedures was 43.4 ± 8.9 minutes (range: 28.5-61.1 minutes). There were no unexpected intraoperative events. SD-OCT confirmed that the sutures were placed at the appropriate depth. We confirm the feasibility of robot-assisted PK with the new Da Vinci Surgical System and report the first use of the Xi model in experimental eye surgery. Operative time of robot-assisted PK surgery is now close to that of conventional manual surgery due to both improvement of the optical system and the presence of microsurgical instruments. Experimentations will allow the advantages of robot-assisted microsurgery to be identified while underlining the improvements and innovations necessary for clinical use.

Novel botanical drug DA-9803 prevents deficits in Alzheimer's mouse models.

PubMed

Pagnier, Guillaume J; Kastanenka, Ksenia V; Sohn, Miwon; Choi, Sangzin; Choi, Song-Hyen; Soh, HyeYeon; Bacskai, Brian J

2018-01-29

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by deposition of amyloid plaques and disruption of neural circuitry, leading to cognitive decline. Animal models of AD deposit senile plaques and exhibit structural and functional deficits in neurons and neural networks. An effective treatment would prevent or restore these deficits, including calcium dyshomeostasis observed with in-vivo imaging. We examined the effects of DA-9803, a multimodal botanical drug, in 5XFAD and APP/PS1 transgenic mice which underwent daily oral treatment with 30 or 100 mg/kg DA-9803 or vehicle alone. Behavioral testing and longitudinal imaging of amyloid deposits and intracellular calcium in neurons with multiphoton microscopy was performed. Chronic administration of DA-9803 restored behavioral deficits in 5XFAD mice and reduced amyloid-β levels. DA-9803 also prevented progressive amyloid plaque deposition in APP/PS1 mice. Elevated calcium, detected in a subset of neurons before the treatment, was restored and served as a functional indicator of treatment efficacy in addition to the behavioral readout. In contrast, mice treated with vehicle alone continued to progressively accumulate amyloid plaques and calcium overload. In summary, treatment with DA-9803 prevented structural and functional outcome measures in mouse models of AD. Thus, DA-9803 shows promise as a novel therapeutic approach for Alzheimer's disease.

Load evaluation of the da Vinci surgical system for transoral robotic surgery.

PubMed

Fujiwara, Kazunori; Fukuhara, Takahiro; Niimi, Koji; Sato, Takahiro; Kitano, Hiroya

2015-12-01

Transoral robotic surgery, performed with the da Vinci surgical system (da Vinci), is a surgical approach for benign and malignant lesions of the oral cavity and laryngopharynx. It provides several unique advantages, which include a 3-dimensional magnified view and ability to see and work around curves or angles. However, the current da Vinci surgical system does not provide haptic feedback. This is problematic because the potential risks specific to the transoral use of the da Vinci include tooth injury, mucosal laceration, ocular injury and mandibular fracture. To assess the potential for intraoperative injuries, we measured the load of the endoscope and the instrument of the da Vinci Si surgical system. We pressed the endoscope and instrument of the da Vinci Si against Load cell six times each and measured the dynamic load and the time-to-maximum load. We also struck the da Vinci Si endoscope and instrument against the Load cell six times each and measured the impact load. The maximum dynamic load was 7.27 ± 1.31 kg for the endoscope and 1.90 ± 0.72 for the instrument. The corresponding time-to-maximum loads were 1.72 ± 0.22 and 1.29 ± 0.34 s, but the impact loads were significantly lower than the dynamic load. It remains possible that a major load is exerted on adjacent structures by continuous contact with the endoscope and instrument of da Vinci Si. However, there is a minor delay in reaching the maximum load. Careful monitoring by an on-site assistant may, therefore, help prevent contiguous injury.

Effects of DA-Phen, a dopamine-aminoacidic conjugate, on alcohol intake and forced abstinence.

PubMed

Sutera, Flavia Maria; De Caro, Viviana; Cannizzaro, Carla; Giannola, Libero Italo; Lavanco, Gianluca; Plescia, Fulvio

2016-09-01

The mesolimbic dopamine (DA) system plays a key role in drug reinforcement and is involved in the development of alcohol addiction. Manipulation of the DAergic system represents a promising strategy to control drug-seeking behavior. Previous studies on 2-amino-N-[2-(3,4-dihydroxy-phenyl)-ethyl]-3-phenyl-propionamide (DA-Phen) showed in vivo effects as a DA-ergic modulator. This study was aimed at investigate DA-Phen effects on operant behavior for alcohol seeking behavior, during reinstatement following subsequent periods of alcohol deprivation. For this purpose, male Wistar rats were tested in an operant paradigm of self-administration; behavioral reactivity and anxiety like-behavior during acute abstinence were evaluated. A characterization of DA-Phen CNS targeting by its quantification in the brain was also carried out. Our findings showed that DA-Phen administration was able to reduce relapse in alcohol drinking by 50% and reversed the alterations in behavioral reactivity and emotionality observed during acute abstinence. In conclusion, DA-Phen can reduce reinstatement of alcohol drinking in an operant-drinking paradigm following deprivation periods and reverse abstinence-induced behavioral phenotype. DA-Phen activity seems to be mediated by the modulation of the DAergic transmission. However further studies are needed to characterize DA-Phen pharmacodynamic and pharmacokinetic properties, and its potential therapeutic profile in alcohol addiction. Copyright © 2016 Elsevier B.V. All rights reserved.

Pharmacological action of DA-9701 on the motility of feline stomach circular smooth muscle.

PubMed

Nguyen, Thanh Thao; Song, Hyun Ju; Ko, Sung Kwon; Sohn, Uy Dong

2015-03-01

DA-9701, a new prokinetic agent for the treatment of functional dyspepsia, is formulated with Pharbitis semen and Corydalis tuber. This study wasconducted to determine the pharmacological action of DA-9701 and to identify the receptors involved in DA-9701 -induced contractile responsesin the feline gastric corporal, fundic and antral circular smooth muscle. Concentration-response curve to DA-9701 was established. The tissue trips were exposed to methylsergide, ketanserin, ondansetron, GR 113808, atropine and dopamine before administration of DA-9701. The contractile force was determined before and after administration of drugs by a polygraph.DA-9701 enhanced the spontaneous contractile amplitude of antrum, corpus and fundus. However, it did not change the spontaneous contractile frequency of antrum and corpus, but concentration-dependently reduced that of fundus. In the fundus, DA-9701 -induced tonic contractions were inhibited by dopamine, methylsergide, ketanserine, ondansetron or GR 113808 respectively, but not by atropine, indicating that the contractile responses are mediated by multiple receptors: 5-HT2, 5-HT3, 5-HT4, and dopamine receptors. In the corpus, DA-9701-induced contractions were blocked by atropine, dopamine or GR 113808, but not by methysergide, ketanserin or ondansetron, indicating that they are involved in receptors on both, smooth muscles and neurons: 5-HT4 and dopamine receptors. However, contractile responses to DA-9701 are mainly mediated by dopamine receptors in the antrum. These results suggest that DA-9701 has important roles in gastric accommodation by enhancing tonic activity of fundus, and in gastric emptying and gastrointestinal transit by phasic contractions of corpus and antrum mediated by multiple receptors.

Inter-annual dynamics of the Barents Sea red king crab (Paralithodes camtschaticus) stock indices in relation to environmental factors

NASA Astrophysics Data System (ADS)

Dvoretsky, Alexander G.; Dvoretsky, Vladimir G.

2016-12-01

Knowledge of relationships between environmental variables and biological processes can greatly improve fisheries assessment and management in commercially important species. We analyzed the effects of environmental factors (climatic indices and water temperature) on the stock characteristics (total population number, number of pre-recruits and number of legal males) of the red king crab (Paralithodes camtschaticus), an introduced species in the Barents Sea. Stock trends in red king crab appear to be related to decadal climate shifts. Abundances were negatively related to the North Atlantic Oscillation index (NAO) in August and positively related to water temperature in late winter-early summer. Total and commercial stock abundance were negatively correlated with the lag-1 Arctic Oscillation index (AO) in August and the lag-2 winter NAO index. The total number of P. camtschaticus was most strongly associated with water temperature in spring and summer and NAO/AO indices in April and May. Lagged NAO indices in February and August (9 or 10 yr) had a positive relationship to the commercial stock of P. camtschaticus. These findings suggest that temperature conditions of current and previous year affect natural mortality of larvae and juvenile red king crabs. Warmer temperature conditions lead to increased biomass of red king crab food items. Negative correlations between climatic indices and the red king crab stocks may be associated with predator pressure on juvenile red king crabs or higher mortality because of predator or parasite pressure and diseases. The associations between stock indices and environmental variables could help better predict recruitment patterns of P. camtschaticus.

Sobre a largura da última superfície de espalhamento

NASA Astrophysics Data System (ADS)

Nobre, M. A. S.; Pires, N.; Lima, J. A. S.

2003-08-01

De acordo com o modelo do "Big-Bang", no universo primordial a matéria estava em equilíbrio térmico com a radiação. Com a expansão a temperatura da radiação cai. Quando a temperatura chega em torno dos 4.000K, os espalhamentos diminuem, começando a recombinação dos prótons e elétrons em Hidrogênio neutro (era conhecida como da recombinação). Ao final da recombinação, os fótons se propagam livremente sofrendo, em princípio, somente os efeitos do "redshift" cosmológico. Esses fótons nos alcançam hoje como a radiação cósmica de fundo (RCF), e parecem vir de uma superfície esférica ao nosso redor, tal que o raio dela é a distância que ele viajou desde seu último espalhamento na época da recombinação. Naturalmente, esse processo não ocorreu abruptamente, implicando na existência de uma largura no espaço dos "redshifts" que deve depender do modelo cosmológico específico e dos processos físicos considerados. Neste trabalho analisamos os efeitos de diferentes modelos - a saber, aqueles com decaimento do vácuo L(t), criação de matéria, quintessência e gás de Chaplygin - sobre a última superfície de espalhamento da RCF, em particular sua largura e a função visibilidade, que determina a probabilidade de um fóton ter tido seu último espalhamento num "redshift" z. No caso particular dos modelos com decaimento do vácuo, existe uma forte dependência da função visibilidade com L(t). Tais efeitos poderão ser testados através da análise dos resultados de experimentos mais precisos que estão atualmente em andamento, como por exemplo, o WMAP.

D-amphetamine (A)-induced dopamine (DA) release is not strictly dependent on newly-synthesized transmitter

DOE Office of Scientific and Technical Information (OSTI.GOV)

Parker, E.; Cubeddu, L.

1986-03-05

A is thought to exert its stimulant effects by releasing DA from a newly synthesized transmitter pool. This hypothesis was evaluated directly by measuring the basal efflux and electrically-evoked release of endogenous DA and dihydroxyphenylacetic acid (DOPAC). In striatal slices from reserpine-treated rabbits A increased DA efflux, reduced DOPAC efflux, and inhibited electrically-evoked /sup 3/H-ACh release in a concentration-dependent manner. These effects could not be mimicked by inhibition of neuronal uptake or MAO, but were blocked by inhibition of DA synthesis or neuronal uptake, and were potentiated by inhibition of MAO. In slices with intact vesicular transmitter stores A inducedmore » DA efflux was 2-fold greater than that seen in slices having no vesicular stores. Inhibition of DA synthesis reduced A-induced DA efflux by 60%, but had little effect on the ability of A to inhibit /sup 3/H-ACh release. A also increased the electrical stimulation-evoked overflow of DA (an effect which was attenuated slightly by synthesis inhibition), and potently inhibited DOPAC overflow. These results suggest that: 1) A facilitates efflux of axoplasmic DA by an accelerated exchange diffusion mechanism. The releasable axoplasmic pool is derived from newly synthesized and vesicular transmitter pools; 2) postsynaptic indices of transmitter release may be misleading; and 3) A increases electrically-evoked DA release possibly by inhibiting neuronal uptake.« less

PD2P: PanDA Dynamic Data Placement for ATLAS

DOE Office of Scientific and Technical Information (OSTI.GOV)

Maeno, T.; De, K.; Panitkin, S.

2012-12-13

The PanDA (Production and Distributed Analysis) system plays a key role in the ATLAS distributed computing infrastructure. PanDA is the ATLAS workload management system for processing all Monte-Carlo (MC) simulation and data reprocessing jobs in addition to user and group analysis jobs. The PanDA Dynamic Data Placement (PD2P) system has been developed to cope with difficulties of data placement for ATLAS. We will describe the design of the new system, its performance during the past year of data taking, dramatic improvements it has brought about in the efficient use of storage and processing resources, and plans for the future.

The Da Vinci European BioBank: A Metabolomics-Driven Infrastructure

PubMed Central

Carotenuto, Dario; Luchinat, Claudio; Marcon, Giordana; Rosato, Antonio; Turano, Paola

2015-01-01

We present here the organization of the recently-constituted da Vinci European BioBank (daVEB, https://www.davincieuropeanbiobank.org/it). The biobank was created as an infrastructure to support the activities of the Fiorgen Foundation (http://www.fiorgen.net/), a nonprofit organization that promotes research in the field of pharmacogenomics and personalized medicine. The way operating procedures concerning samples and data have been developed at daVEB largely stems from the strong metabolomics connotation of Fiorgen and from the involvement of the scientific collaborators of the foundation in international/European projects aimed to tackle the standardization of pre-analytical procedures and the promotion of data standards in metabolomics. PMID:25913579

Performances on simulator and da Vinci robot on subjects with and without surgical background.

PubMed

Moglia, Andrea; Ferrari, Vincenzo; Melfi, Franca; Ferrari, Mauro; Mosca, Franco; Cuschieri, Alfred; Morelli, Luca

2017-08-17

To assess whether previous training in surgery influences performance on da Vinci Skills Simulator and da Vinci robot. In this prospective study, thirty-seven participants (11 medical students, 17 residents, and 9 attending surgeons) without previous experience in laparoscopy and robotic surgery performed 26 exercises at da Vinci Skills Simulator. Thirty-five then executed a suture using a da Vinci robot. The overall scores on the exercises at the da Vinci Skills Simulator show a similar performance among the groups with no statistically significant pair-wise differences (p < .05). The quality of the suturing based on the unedited videos of the test run was similar for the intermediate (7 (4, 10)) and expert group (6.5 (4.5, 10)), and poor for the untrained groups (5 (3.5, 9)), without statistically significant difference (p < .05). This study showed, for subjects new to laparoscopy and robotic surgery, insignificant differences in the scores at the da Vinci Skills Simulator and at the da Vinci robot on inanimate models.

Ecological Carrying Capacity of Land Use Changes in Da'an City

NASA Astrophysics Data System (ADS)

Wang, H.; Zhang, J.; Li, B.

2018-04-01

Based on GIS and RS technology, this paper analyzed the land use change in Da'an city from 1995 to 2010. land-use ecological evaluation index was constructed to evaluate the land-use ecological risk of Da 'an city dynamically, and the land-use ecological risk level map was made, and then the distribution and change of the land-use ecological carrying capacity pattern of Da'an city were analyzed qualitatively. According to the evaluation results of ecological carrying capacity, the ecological environment of Da'an city has deteriorated in fifteen years. in 1995, the poor ecological environment area is mainly distributed in the northeast area of Da'an city, and the area is small, while the area of the central and southern areas is large; In 2010, the western region also appeared environmental degradation, the northeast environment deterioration is serious, the dominant area is reduced, and a small amount of deterioration in the central and southern regions. According to the study of this paper, in the future, we should strengthen the comprehensive management of this part of the area, strengthen vegetation coverage, reduce soil erosion, ensure the effective improvement of ecological environment.

The real code of leonardo da vinci.

PubMed

Ose, Leiv

2008-02-01

Leonardo da Vinci was born in Italy. Among the researchers and scientists, he is favourably known for his remarkable efforts in scientific work. His investigations of atherosclerosis judiciously combine three separate fields of research. In 1506, he finished his masterpiece, painting of Mona Lisa. A careful clinical examination of the famous painting reveals a yellow irregular leather-like spot at the inner end of the left upper eyelid and a soft bumpy well-defined swelling of the dorsum of the right hand beneath the index finger about 3 cm long. This is probably the first case of familial hypercholesterolemia (FH). The FH code of Leonardo da Vinci was given immense consideration by scientists like Carl Muller, who described the xanthomas tuberosum and angina pectoris. On the contrary, Akira Endo searched for microbial metabolites that would inhibit HMG-CoA reductase, the rate-limiting enzyme in the synthesis of cholesterol and finally, Michael Brown and Joseph Goldstein published a remarkable series of elegant and insightful papers in the 70s and 80s. They established that the cellular uptake of low-density lipoprotein (LDL) essentially requires the LDL receptor. this was the real Code of Leonardo da Vinci.

Leonardo da Vinci's studies of the heart.

PubMed

Shoja, Mohammadali M; Agutter, Paul S; Loukas, Marios; Benninger, Brion; Shokouhi, Ghaffar; Namdar, Husain; Ghabili, Kamyar; Khalili, Majid; Tubbs, R Shane

2013-08-20

Leonardo da Vinci's detailed drawings are justly celebrated; however, less well known are his accounts of the structures and functions of the organs. In this paper, we focus on his illustrations of the heart, his conjectures about heart and blood vessel function, his experiments on model systems to test those conjectures, and his unprecedented conclusions about the way in which the cardiovascular system operates. In particular, da Vinci seems to have been the first to recognize that the heart is a muscle and that systole is the active phase of the pump. He also seems to have understood the functions of the auricles and pulmonary veins, identified the relationship between the cardiac cycle and the pulse, and explained the hemodynamic mechanism of valve opening and closure. He also described anatomical variations and changes in structure and function that occurred with age. We outline da Vinci's varied career and suggest ways in which his personality, experience, skills and intellectual heritage contributed to these advances in understanding. We also consider his influence on later studies in anatomy and physiology. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

[RESEARCH PROGRESS OF PERIPHERAL NERVE SURGERY ASSISTED BY Da Vinci ROBOTIC SYSTEM].

PubMed

Shen, Jie; Song, Diyu; Wang, Xiaoyu; Wang, Changjiang; Zhang, Shuming

2016-02-01

To summarize the research progress of peripheral nerve surgery assisted by Da Vinci robotic system. The recent domestic and international articles about peripheral nerve surgery assisted by Da Vinci robotic system were reviewed and summarized. Compared with conventional microsurgery, peripheral nerve surgery assisted by Da Vinci robotic system has distinctive advantages, such as elimination of physiological tremors and three-dimensional high-resolution vision. It is possible to perform robot assisted limb nerve surgery using either the traditional brachial plexus approach or the mini-invasive approach. The development of Da Vinci robotic system has revealed new perspectives in peripheral nerve surgery. But it has still been at the initial stage, more basic and clinical researches are still needed.

Is da Vinci Xi Better than da Vinci Si in Robotic Rectal Cancer Surgery? Comparison of the 2 Generations of da Vinci Systems.

PubMed

Ozben, Volkan; Cengiz, Turgut B; Atasoy, Deniz; Bayraktar, Onur; Aghayeva, Afag; Erguner, Ilknur; Baca, Bilgi; Hamzaoglu, Ismail; Karahasanoglu, Tayfun

2016-10-01

We aimed to compare perioperative outcomes for procedures using the latest generation of da Vinci robot versus its previous version in rectal cancer surgery. Fifty-three patients undergoing robotic rectal cancer surgery between January 2010 and March 2015 were included. Patients were classified into 2 groups (Xi, n=28 vs. Si, n=25) and perioperative outcomes were analyzed. The groups had significant differences including operative procedure, hybrid technique and redocking (P>0.05). In univariate analysis, the Xi group had shorter console times (265.7 vs. 317.1 min, P=0.006) and total operative times (321.6 vs. 360.4 min, P=0.04) and higher number of lymph nodes harvested (27.5 vs. 17.0, P=0.008). In multivariate analysis, Xi robot was associated with a shorter console time (odds ratio: 0.09, P=0.004) with no significant differences regarding other outcomes. Both generations of da Vinci robot led to similar short-term outcomes in rectal cancer surgery, but the Xi robot allowed shorter console times.

OpenDA-WFLOW framework for improving hydrologic predictions using distributed hydrologic models

NASA Astrophysics Data System (ADS)

Weerts, Albrecht; Schellekens, Jaap; Kockx, Arno; Hummel, Stef

2017-04-01

Data assimilation (DA) holds considerable potential for improving hydrologic predictions (Liu et al., 2012) and increase the potential for early warning and/or smart water management. However, advances in hydrologic DA research have not yet been adequately or timely implemented in operational forecast systems to improve the skill of forecasts for better informed real-world decision making. The objective of this work is to highlight the development of a generic linkage of the open source OpenDA package and the open source community hydrologic modeling framework Openstreams/WFLOW and its application in operational hydrological forecasting on various spatial scales. The coupling between OpenDA and Openstreams/wflow framework is based on the emerging standard Basic Model Interface (BMI) as advocated by CSDMS using cross-platform webservices (i.e. Apache Thrift) developed by Hut et al. (2016). The potential application of the OpenDA-WFLOW for operational hydrologic forecasting including its integration with Delft-FEWS (used by more than 40 operational forecast centers around the world (Werner et al., 2013)) is demonstrated by the presented case studies. We will also highlight the possibility to give real-time insight into the working of the DA methods applied for supporting the forecaster as mentioned as one of the burning issues by Liu et al., (2012).

32 CFR 644.512 - DA-SBA joint set-aside determination.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 4 2010-07-01 2010-07-01 true DA-SBA joint set-aside determination. 644.512 Section 644.512 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY (CONTINUED) REAL... Stone § 644.512 DA-SBA joint set-aside determination. Section 15 of the Small Business Act (15 U.S.C...

Leonardo da Vinci's foot: historical evidence of concept.

PubMed

Jastifer, James R; Toledo-Pereyra, Luis H

2012-10-01

Leonardo da Vinci (1452-1519), world-renowned Italian renaissance master, is known for his contributions to, and broad interests in science and art. The objective of this work is to demonstrate the extent of his science by applying the use of his concepts to current models of foot and ankle mechanics. The art and science of Leonardo Da Vinci were extensively analyzed by reviewing his original drawings and hand written notebooks as well as their English translation. Current medical journals including the topics of foot, ankle, and biomechanics were reviewed for modern evidence and application of his concepts. The library of Michigan State University and the electronic library of the Royal Library at Windsor Castle were extensively utilized. From the depths of Santa Maria Nuova Hospital in Florence and Santo Spirito Hospital in Rome, through his commentary and anatomical drawings of around 30 cadaver dissections he performed, Leonardo da Vinci expressed his concept of foot and ankle anatomy and mechanics. He laid forth concepts, which vary little from current theories including those of proportion, statics and joint stability, sesamoid biomechanics, and structural support of the foot. Leonardo da Vinci, by combining an interest in anatomy and a gift of genius and artistic ability laid a foundation of foot and ankle anatomy and mechanics that have been applied in modern clinical sciences. Leonardo in this way made important contributions to the practice of foot and ankle orthopedics.

Beyond the Classic VTA: Extended Amygdala Projections to DA-Striatal Paths in the Primate

PubMed Central

Fudge, Julie L; Kelly, Emily A; Pal, Ria; Bedont, Joseph L; Park, Lydia; Ho, Brian

2017-01-01

The central extended amygdala (CEA) has been conceptualized as a ‘macrosystem’ that regulates various stress-induced behaviors. Consistent with this, the CEA highly expresses corticotropin-releasing factor (CRF), an important modulator of stress responses. Stress alters goal-directed responses associated with striatal paths, including maladaptive responses such as drug seeking, social withdrawal, and compulsive behavior. CEA inputs to the midbrain dopamine (DA) system are positioned to influence striatal functions through mesolimbic DA-striatal pathways. However, the structure of this amygdala-CEA-DA neuron path to the striatum has been poorly characterized in primates. In primates, we combined neuronal tracer injections into various arms of the circuit through specific DA subpopulations to assess: (1) whether the circuit connecting amygdala, CEA, and DA cells follows CEA intrinsic organization, or a more direct topography involving bed nucleus vs central nucleus divisions; (2) CRF content of the CEA-DA path; and (3) striatal subregions specifically involved in CEA-DA-striatal loops. We found that the amygdala-CEA-DA path follows macrostructural subdivisions, with the majority of input/outputs converging in the medial central nucleus, the sublenticular extended amygdala, and the posterior lateral bed nucleus of the stria terminalis. The proportion of CRF+ outputs is >50%, and mainly targets the A10 parabrachial pigmented nucleus (PBP) and A8 (retrorubal field, RRF) neuronal subpopulations, with additional inputs to the dorsal A9 neurons. CRF-enriched CEA-DA projections are positioned to influence outputs to the ‘limbic-associative’ striatum, which is distinct from striatal regions targeted by DA cells lacking CEA input. We conclude that the concept of the CEA is supported on connectional grounds, and that CEA termination over the PBP and RRF neuronal populations can influence striatal circuits involved in associative learning. PMID:28220796

Beyond the Classic VTA: Extended Amygdala Projections to DA-Striatal Paths in the Primate.

PubMed

Fudge, Julie L; Kelly, Emily A; Pal, Ria; Bedont, Joseph L; Park, Lydia; Ho, Brian

2017-07-01

The central extended amygdala (CEA) has been conceptualized as a 'macrosystem' that regulates various stress-induced behaviors. Consistent with this, the CEA highly expresses corticotropin-releasing factor (CRF), an important modulator of stress responses. Stress alters goal-directed responses associated with striatal paths, including maladaptive responses such as drug seeking, social withdrawal, and compulsive behavior. CEA inputs to the midbrain dopamine (DA) system are positioned to influence striatal functions through mesolimbic DA-striatal pathways. However, the structure of this amygdala-CEA-DA neuron path to the striatum has been poorly characterized in primates. In primates, we combined neuronal tracer injections into various arms of the circuit through specific DA subpopulations to assess: (1) whether the circuit connecting amygdala, CEA, and DA cells follows CEA intrinsic organization, or a more direct topography involving bed nucleus vs central nucleus divisions; (2) CRF content of the CEA-DA path; and (3) striatal subregions specifically involved in CEA-DA-striatal loops. We found that the amygdala-CEA-DA path follows macrostructural subdivisions, with the majority of input/outputs converging in the medial central nucleus, the sublenticular extended amygdala, and the posterior lateral bed nucleus of the stria terminalis. The proportion of CRF+ outputs is >50%, and mainly targets the A10 parabrachial pigmented nucleus (PBP) and A8 (retrorubal field, RRF) neuronal subpopulations, with additional inputs to the dorsal A9 neurons. CRF-enriched CEA-DA projections are positioned to influence outputs to the 'limbic-associative' striatum, which is distinct from striatal regions targeted by DA cells lacking CEA input. We conclude that the concept of the CEA is supported on connectional grounds, and that CEA termination over the PBP and RRF neuronal populations can influence striatal circuits involved in associative learning.

Effect of DA-9701 on Colorectal Distension-Induced Visceral Hypersensitivity in a Rat Model

PubMed Central

Kim, Eun Ran; Min, Byung-Hoon; Lee, Tae Ho; Son, Miwon; Rhee, Poong-Lyul

2014-01-01

Background/Aims DA-9701 is a newly developed drug made from the vegetal extracts of Pharbitidis semen and Co-rydalis tuber. The aim of this study was to evaluate the effect of DA-9701 on colorectal distension (CRD)-induced visceral hypersensitivity in a rat model. Methods Male Sprague-Dawley rats were subjected to neonatal colon irritation (CI) using CRD at 1 week after birth (CI group). At 6 weeks after birth, CRD was applied to these rats with a pressure of 20 to 90 mm Hg, and changes in the mean arterial pressure (MAP) were measured at baseline (i.e., without any drug administration) and after the administration of different doses of DA-9701. Results In the absence of DA-9701, the MAP changes after CRD were significantly higher in the CI group than in the control group at all applied pressures. In the control group, MAP changes after CRD were not significantly affected by the administration of DA-9701. In the CI group, however, the administration of DA-9701 resulted in a significant decrease in MAP changes after CRD. The administration of DA-9701 at a dose of 1.0 mg/kg produced a more significant decrease in MAP changes than the 0.3 mg/kg dose. Conclusions The administration of DA-9701 resulted in a significant increase in pain threshold in rats with CRD-induced visceral hypersensitivity. PMID:25071903

Effect of DA-9701 on colorectal distension-induced visceral hypersensitivity in a rat model.

PubMed

Kim, Eun Ran; Min, Byung-Hoon; Lee, Tae Ho; Son, Miwon; Rhee, Poong-Lyul

2014-07-01

DA-9701 is a newly developed drug made from the vegetal extracts of Pharbitidis semen and Co-rydalis tuber. The aim of this study was to evaluate the effect of DA-9701 on colorectal distension (CRD)-induced visceral hypersensitivity in a rat model. Male Sprague-Dawley rats were subjected to neonatal colon irritation (CI) using CRD at 1 week after birth (CI group). At 6 weeks after birth, CRD was applied to these rats with a pressure of 20 to 90 mm Hg, and changes in the mean arterial pressure (MAP) were measured at baseline (i.e., without any drug administration) and after the administration of different doses of DA-9701. In the absence of DA-9701, the MAP changes after CRD were significantly higher in the CI group than in the control group at all applied pressures. In the control group, MAP changes after CRD were not significantly affected by the administration of DA-9701. In the CI group, however, the administration of DA-9701 resulted in a significant decrease in MAP changes after CRD. The administration of DA-9701 at a dose of 1.0 mg/kg produced a more significant decrease in MAP changes than the 0.3 mg/kg dose. The administration of DA-9701 resulted in a significant increase in pain threshold in rats with CRD-induced visceral hypersensitivity.

Fluorescence growth of self-polymerized fluorescence polydopamine for ratiometric visual detection of DA.

PubMed

Yu, Miao; Lu, Yang; Tan, Zhenjiang

2017-06-01

In this work, a novel and facile ratiometric fluorescence probe was prepared for the visual detection of dopamine (DA). In this detection system, red-emission CdTe@SiO 2 (r-QDs@SiO 2 ) was used as steady core of the probe and inverse microemulsion method was applied to synthesize uniform r-QDs@SiO 2 , this step could protect CdTe from contacting with human skin directly. Polydopamine (PDA) acted as response signal to detect DA, a very handy method which just combined polyethyleneimine (PEI) with DA together to synthesize PDA, this way for synthesis of PDA was much time-saving and non-toxic than any other methods. Differently from traditional analysis processes, the products of this experiment were also the analysis substances in final. Under optimum measurement conditions, the dual-emission ratiometric fluorescence probe was used for detections of DA in a concentration ranged from 10μM to 80μM with a detection limit of 0.12μM, with addition of DA the color of the probe changed from red to green watched by naked eyes. In addition, the developed probe was also used for detections of DA in human serum samples successfully. This study provides a simple, time-saving and non-toxic approach for detections of DA without the requirement of complex equipment. Copyright © 2017 Elsevier B.V. All rights reserved.

Thinking like Leonardo da Vinci and its implications for the modern doctor.

PubMed

Baum, Neil

2013-01-01

Most people when asked to name the most creative, innovative, and multidimensional people in history would agree that Leonardo da Vinci is either at the top or very close to the number one position on that list. Wouldn't it be nice to think like da Vinci? This article shares the seven unique principles of thinking that da Vinci used that enabled him to be the greatest painter, sculptor, architect, musician, mathematician, engineer, inventor, anatomist, geologist, cartographer, botanist, and writer of his (if not of all) time. This article will take you deep into the notebooks and codices of da Vinci, and suggest ways his ideas can be used by anyone in the healthcare profession to make them a better healthcare provider.

76 FR 31457 - Airworthiness Directives; Diamond Aircraft Industries GmbH Model DA 42 Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-01

... Airworthiness Directives; Diamond Aircraft Industries GmbH Model DA 42 Airplanes AGENCY: Federal Aviation... reportedly found on DA 42 Main Landing Gear (MLG) Damper-to-Trailing Arm joints during standard maintenance... DA 42 Main Landing Gear (MLG) Damper-to-Trailing Arm joints during standard maintenance. Depending on...

Leonardo Da Vinci and stroke - vegetarian diet as a possible cause.

PubMed

Oztürk, Serefnur; Altieri, Marta; Troisi, Pina

2010-01-01

Leonardo da Vinci (April 15, 1452 to May 2, 1519) was an Italian Renaissance architect, musician, anatomist, inventor, engineer, sculptor, geometer, and painter. It has been gleaned from the many available historical documents that da Vinci was a vegetarian who respected and loved animals, and that he suffered from right hemiparesis in the last 5 years of his life. A vegetarian diet has both positive and negative influences on the cerebrovascular system. In this report, a possible relation between a vegetarian diet and stroke is discussed from various perspectives as related to Leonardo da Vinci's stroke. Copyright (c) 2010 S. Karger AG, Basel.

Early clinical experience with the da Vinci Xi Surgical System in general surgery.

PubMed

Hagen, Monika E; Jung, Minoa K; Ris, Frederic; Fakhro, Jassim; Buchs, Nicolas C; Buehler, Leo; Morel, Philippe

2017-09-01

The da Vinci Xi Surgical System (Intuitive Surgical Inc., Sunnyvale, CA, USA) has been released in 2014 to facilitate minimally invasive surgery. Novel features are targeted towards facilitating complex multi-quadrant procedures, but data is scarce so far. Perioperative data of patients who underwent robotic general surgery with the da Vinci Xi system within the first 6 month after installation were collected and analyzed. The gastric bypass procedures performed with the da Vinci Xi Surgical System were compared to an equal amount of the last procedures with the da Vinci Si Surgical System. Thirty-one foregut (28 Roux-en-Y gastric bypasses), 6 colorectal procedures and 1 revisional biliary procedure were performed. The mean operating room (OR) time was 221.8 (±69.0) minutes for gastric bypasses and 306.5 (±48.8) for colorectal procedures with mean docking time of 9.4 (±3.8) minutes. The gastric bypass procedure was transitioned from a hybrid to a fully robotic approach. In comparison to the last 28 gastric bypass procedures performed with the da Vinci Si Surgical System, the OR time was comparable (226.9 versus 230.6 min, p = 0.8094), but the docking time significantly longer with the da Vinci Xi Surgical System (8.5 versus 6.1 min, p = 0.0415). All colorectal procedures were performed with a single robotic docking. No intraoperative and two postoperative complications occurred. The da Vinci Xi might facilitate single-setups of totally robotic gastric bypass and colorectal surgeries. However, further comparable research is needed to clearly determine the significance of this latest version of the da Vinci Surgical System.

76 FR 14346 - Airworthiness Directives; Diamond Aircraft Industries GmbH Model DA 42 Airplanes

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-16

... Industries GmbH Model DA 42 Airplanes AGENCY: Federal Aviation Administration (FAA), Department of... been reportedly found on DA 42 Main Landing Gear (MLG) Damper-to-Trailing Arm joints during standard... condition for the specified products. The MCAI states: Cracks have been reportedly found on DA 42 Main...

[Diagnostic Accuracy of the LiSe-DaZ for Children with Specific Language Impairment].

PubMed

Stephan, T; Keilmann, A

2015-12-01

Currently, only few tests for the development of speech and language exist for bi- or multilingual children in Germany. One of those, the LiSe-DaZ (Linguistic performance measurement - German as a second language), was examined in a prospective study regarding its practicability and the sensitivity to detect children with specific language impairment in a group of children aged 5 to 7 who suffered from a severe language impairment according to clinical tests. 74 children (mean age: 60 months; 46% monolingual German-speaking; 54% bi- or multilingual) with severe specific language impairment were examined with the LiSe-DaZ in addition to the clinical established diagnostic during their in-patient stay in the hospital. The children, on average, showed in the receptive language abilities (LiSe-DaZ vs. TROG-D), the expressive vocabulary (LiSe-DaZ vs. AWST-R or WWT) and in the use of prepositions (LiSe-DaZ vs. Ravensburger Dysgrammatical clinical trial) significantly (p<0,0005) better results in the LiSe-DaZ. Thus, the majority of children were diagnosed as language impaired by clinically established tests whereas the LiSe-DaZ considered the children's language development to be normal. This difference was consistently more prominent for children with German as a second language. Compared with the clinically established tests, the informative value of the LiSe-DaZ turned out to be insufficient. The LiSe-DaZ does not detect children with the need of language therapy. Nevertheless, a norming of the established speech tests for bi- or multilingual children would be desirable to avoid unfounded judgements. © Georg Thieme Verlag KG Stuttgart · New York.

Contribution of atmospheric circulation to recent off-shore sea-level variations in the Baltic Sea and the North Sea

NASA Astrophysics Data System (ADS)

Karabil, Sitar; Zorita, Eduardo; Hünicke, Birgit

2018-01-01

The main purpose of this study is to quantify the contribution of atmospheric factors to recent off-shore sea-level variability in the Baltic Sea and the North Sea on interannual timescales. For this purpose, we statistically analysed sea-level records from tide gauges and satellite altimetry and several climatic data sets covering the last century. Previous studies had concluded that the North Atlantic Oscillation (NAO) is the main pattern of atmospheric variability affecting sea level in the Baltic Sea and the North Sea in wintertime. However, we identify a different atmospheric circulation pattern that is more closely connected to sea-level variability than the NAO. This circulation pattern displays a link to sea level that remains stable through the 20th century, in contrast to the much more variable link between sea level and the NAO. We denote this atmospheric variability mode as the Baltic Sea and North Sea Oscillation (BANOS) index. The sea-level pressure (SLP) BANOS pattern displays an SLP dipole with centres of action located over (5° W, 45° N) and (20° E, 70° N) and this is distinct from the standard NAO SLP pattern in wintertime. In summertime, the discrepancy between the SLP BANOS and NAO patterns becomes clearer, with centres of action of the former located over (30° E, 45° N) and (20° E, 60° N). This index has a stronger connection to off-shore sea-level variability in the study area than the NAO in wintertime for the period 1993-2013, explaining locally up to 90 % of the interannual sea-level variance in winter and up to 79 % in summer. The eastern part of the Gulf of Finland is the area where the BANOS index is most sensitive to sea level in wintertime, whereas the Gulf of Riga is the most sensitive region in summertime. In the North Sea region, the maximum sea-level sensitivity to the BANOS pattern is located in the German Bight for both winter and summer seasons. We investigated, and when possible quantified, the contribution of several

Leonardo da Vinci (1452-1519) and his depictions of the human spine.

PubMed

Bowen, Garvin; Gonzales, Jocelyn; Iwanaga, Joe; Fisahn, Christian; Loukas, Marios; Oskouian, Rod J; Tubbs, R Shane

2017-12-01

Few individuals in history have exerted so great an influence and made such extensive contributions to so many disciplines as Leonardo da Vinci. Da Vinci's inquisitive, experimental mentality led him to many discoveries, such as spinal cord function and the proper anatomy of several organ systems. Respected not only as an artist but also as an anatomist, he made many significant contributions to the field. This article explores da Vinci's drawings, in relation to the anatomy of the human spine.

Impact of the North Atlantic Oscillation on winter precipitation totals in Slovakia

NASA Astrophysics Data System (ADS)

Leskova, Livia; Stastny, Pavel

2013-04-01

The North Atlantic Oscillation (NAO) is the most important circulation mode in the Northern Hemisphere, which impacts climate in Europe in various ways. The strongest impacts of oscillation on air temperature and precipitation regime are detected in Scandinavia and Mediterranean region, but impacts have opposite effect. Therefore, assessment of the relation between NAO and precipitation totals seems to be interesting in Slovakia, because of the country location in the centre between above mentioned regions. Our former research detected only the relation between NAO and a winter precipitation totals in Slovakia. More detailed aspects of this relation is analysed in this paper. A correlation method was used at two resolution levels, which detected opposite spatial impact of NAO on above mentioned seasonal precipitation. The first generalised level was based on the precipitation regions, which were distinguished on the base of characteristic precipitation regime of individual regions. The second level was more detailed and the correlation method was applied on data of every individual rain gauge station from the set of 202 rain gauge stations with complete data for period 1901 - 2010 in Slovakia. In the northern part of the country (Orava and Kysuce regions), there was found the positive correlation. Increase in the winter precipitation totals was recorded in the same regions and general precipitation trend in this area was similar to the trend in used Hurrell oscillation index. It means, following the increasing trend in oscillation course, we can also expect the increase in precipitation totals in these regions in the near future. In a southward direction, this correlation changed to the negative values and the most negative correlation coefficients were reached in the lowland regions (Podunajská and Východoslovenská nížina) and in the region of Juhoslovenská kotlina. This last mentioned region is located in multiple precipitation shadow of Carpathians

The Use of Oceanic Indices Variations Due to Climate Change to Predict Annual Discharge Variations in Northeastern United States

NASA Astrophysics Data System (ADS)

Berton, R.; Shaw, S. B.; Chandler, D. G.; Driscoll, C. T.

2014-12-01

Climatic change affects streamflow in watersheds with winter snowpack and an annual snowmelt hydrograph. In the northeastern US, changes in streamflow are driven by both the advanced timing of snowmelt and increasing summer precipitation. Projections of climate for the region in the 21st century is for warmer winters and wetter summers. Water planners need to understand future changes in flow metrics to determine if the current water resources are capable of fulfilling future demands or adapting to future changes in climate. The study of teleconnection patterns between oceanic indices variations and hydrologic variables may help improve the understanding of future water resources conditions in a watershed. The purpose of this study is to evaluate the correlation between oceanic indices and discharge variations in the Merrimack Watershed. The Merrimack Watershed is the fourth largest basin in New England which drains much of New Hampshire and northeastern portions of Massachusetts, USA. Variations in sea surface temperature (SST) and sea level pressure (SLP) are defined by the Atlantic Multi-decadal Oscillation (AMO) and the North Atlantic Oscillation (NAO), respectively. We hypothesize that temporal changes in discharge are related to AMO and NAO variations since precipitation and discharge are highly correlated in the Merrimack. The Merrimack Watershed consists of undisturbed (reference) catchments and disturbed (developed) basins with long stream gauge records (> 100 years). Developed basins provide an opportunity to evaluate the impacts of river regulation and land development on teleconnection patterns as well as changing climate. Time series of AMO and NAO indices over the past 150 years along with Merrimack annual precipitation and discharge time series have shown a 1 to 2-year watershed hydrologic memory; higher correlation between Merrimack‎ annual precipitation and discharge with AMO and NAO are observed when a 1 to 2-year lag is given to AMO and NAO

The Real Code of Leonardo da Vinci

PubMed Central

Ose, Leiv

2008-01-01

Leonardo da Vinci was born in Italy. Among the researchers and scientists, he is favourably known for his remarkable efforts in scientific work. His investigations of atherosclerosis judiciously combine three separate fields of research. In 1506, he finished his masterpiece, painting of Mona Lisa. A careful clinical examination of the famous painting reveals a yellow irregular leather-like spot at the inner end of the left upper eyelid and a soft bumpy well-defined swelling of the dorsum of the right hand beneath the index finger about 3 cm long. This is probably the first case of familial hypercholesterolemia (FH). The FH code of Leonardo da Vinci was given immense consideration by scientists like Carl Muller, who described the xanthomas tuberosum and angina pectoris. On the contrary, Akira Endo searched for microbial metabolites that would inhibit HMG-CoA reductase, the rate-limiting enzyme in the synthesis of cholesterol and finally, Michael Brown and Joseph Goldstein published a remarkable series of elegant and insightful papers in the 70s and 80s. They established that the cellular uptake of low-density lipoprotein (LDL) essentially requires the LDL receptor. In conclusion: this was the real Code of Leonardo da Vinci. PMID:19924278

[The rational application of Da Vinci surgical system in thyroidectomy].

PubMed

He, Q Q

2017-08-01

Da Vinci surgical system is the most advanced minimally invasive surgical platform in the world, and this system has been widely used in cardiac surgery, urology surgery, gynecologic surgery and general surgery. Although the application of this system was relatively late in thyroid surgery, the number of thyroidectomy with Da Vinci surgical system is increasing quickly. Having reviewed recent studies and summarized clinical experience, compared with traditional open operation, the robotic thyroidectomy has the same surgical safety and effectiveness in selective patients with thyroid cancer. In this paper, several aspects on this novel operation were demonstrated, including surgical indications and contraindications, the approaches, surgical procedures and postoperative complications, in order to promote the rational application of Da Vinci surgical system in thyroidectomy.

32 CFR 635.23 - DA Form 4833 (Commander's Report of Disciplinary or Administrative Action).

Code of Federal Regulations, 2014 CFR

2014-07-01

... the PMO. The Battalion Commander or the first Lieutenant Colonel in the chain of command is... DA Form 4833 within 45 days of receipt. (1) Appropriate blocks will be checked and blanks annotated... the disposition on DA Form 4833 as appropriate. That portion of the signature block of DA Form 4833...

32 CFR 635.23 - DA Form 4833 (Commander's Report of Disciplinary or Administrative Action).

Code of Federal Regulations, 2010 CFR

2010-07-01

... the PMO. The Battalion Commander or the first Lieutenant Colonel in the chain of command is... DA Form 4833 within 45 days of receipt. (1) Appropriate blocks will be checked and blanks annotated... the disposition on DA Form 4833 as appropriate. That portion of the signature block of DA Form 4833...

32 CFR 635.23 - DA Form 4833 (Commander's Report of Disciplinary or Administrative Action).

Code of Federal Regulations, 2011 CFR

2011-07-01

... the PMO. The Battalion Commander or the first Lieutenant Colonel in the chain of command is... DA Form 4833 within 45 days of receipt. (1) Appropriate blocks will be checked and blanks annotated... the disposition on DA Form 4833 as appropriate. That portion of the signature block of DA Form 4833...

32 CFR 635.23 - DA Form 4833 (Commander's Report of Disciplinary or Administrative Action).

Code of Federal Regulations, 2013 CFR

2013-07-01

... the PMO. The Battalion Commander or the first Lieutenant Colonel in the chain of command is... DA Form 4833 within 45 days of receipt. (1) Appropriate blocks will be checked and blanks annotated... the disposition on DA Form 4833 as appropriate. That portion of the signature block of DA Form 4833...

32 CFR 635.23 - DA Form 4833 (Commander's Report of Disciplinary or Administrative Action).

Code of Federal Regulations, 2012 CFR

2012-07-01

... the PMO. The Battalion Commander or the first Lieutenant Colonel in the chain of command is... DA Form 4833 within 45 days of receipt. (1) Appropriate blocks will be checked and blanks annotated... the disposition on DA Form 4833 as appropriate. That portion of the signature block of DA Form 4833...

Linkages Between Terrestrial Carbon Uptake and Interannual Climate Variability over the Texas-northern Mexico High Plains

NASA Astrophysics Data System (ADS)

Parazoo, N.; Barnes, E. A.; Worden, J.; Harper, A. B.; Bowman, K. W.; Frankenberg, C.

2014-12-01

The Texas-northern Mexico high plains experienced record drought conditions in 2011 during strong negative phases of ENSO and the NAO. Given predictions of increased frequency and severity of drought under projected climate change [e.g., Reichstein et al., 2013] and recent findings of CO2 growth rate sensitivity to interannual variability of carbon uptake in semi-arid ecosystems [Poulter et al., 2014], we investigate the response of carbon uptake in the Texas high plains to interannual climate variability with the goal of improved mechanistic understanding of climate-carbon cycle links. Specifically, we examine (1) observed tendencies in regional scale carbon uptake and soil moisture from 2010 to 2011 using satellite observations of gross primary production (GPP) (from plant fluorescence) from GOSAT and soil moisture from SMOS, and (2) the interannual relationship between GPP and ENSO & NAO variability using terrestrial biosphere simulations from 1950-2012. Observations reveal widespread decline of GPP in 2011 (0.42 +/- 0.04 Pg C yr-1) correlated with negative soil moisture tendencies (r = 0.85 +/- 0.21) which leads to corresponding declines in net carbon uptake and transpiration (according to model simulations). Further examination of model results over the period 1950-2012 indicates that negative GPP anomalies are linked systematically to winter and spring precipitation deficits associated with overlapping negative phases of winter NAO and ENSO, with increasing magnitude of negative anomalies in strong La Niña years. Furthermore, the strongest decline of GPP, carbon uptake, and transpiration on record occurred during the 2011 drought and were associated with extreme negative phases of ENSO and NAO, with 2011 being the only year since 1950 that both indices exceeded 1 σ standard deviation.

Linear and nonlinear winter atmospheric responses to extreme phases of low frequency Pacific sea surface temperature variability

NASA Astrophysics Data System (ADS)

Cao, Dandan; Wu, Qigang; Hu, Aixue; Yao, Yonghong; Liu, Shizuo; Schroeder, Steven R.; Yang, Fucheng

2018-02-01

This study examines Northern Hemisphere winter (DJFM) atmospheric responses to opposite strong phases of interdecadal (low frequency, LF) Pacific sea surface temperature (SST) forcing, which resembles El Niño-Southern Oscillation (ENSO) on a longer time scale, in observations and GFDL and CAM4 model simulations. Over the Pacific-North America (PNA) sector, linear observed responses of 500-hPa height (Z500) anomalies resemble the PNA teleconnection pattern, but show a PNA-like nonlinear response because of a westward Z500 shift in the negative (LF-) relative to the positive LF (LF+) phase. Significant extratropical linear responses include a North Atlantic Oscillation (NAO)-like Z500 anomaly, a dipole-like Z500 anomaly over northern Eurasia associated with warming over mid-high latitude Eurasia, and a Southern Annular anomaly pattern associated with warming in southern land areas. Significant nonlinear Z500 responses also include a NAO-like anomaly pattern. Models forced by LF+ and LF- SST anomalies reproduce many aspects of observed linear and nonlinear responses over the Pacific-North America sector, and linear responses over southern land, but not in the North Atlantic-European sector and Eurasia. Both models simulate PNA-like linear responses in the North Pacific-North America region similar to observed, but show larger PNA-like LF+ responses, resulting in a PNA nonlinear response. The nonlinear PNA responses result from both nonlinear western tropical Pacific rainfall changes and extratropical transient eddy feedbacks. With LF tropical Pacific forcing only (LFTP+ and LFTP-, climatological SST elsewhere), CAM4 simulates a significant NAO response to LFTP-, including a linear negative and nonlinear positive NAO response.

Numerical Analysis Objects

NASA Astrophysics Data System (ADS)

Henderson, Michael

1997-08-01

The Numerical Analysis Objects project (NAO) is a project in the Mathematics Department of IBM's TJ Watson Research Center. While there are plenty of numerical tools available today, it is not an easy task to combine them into a custom application. NAO is directed at the dual problems of building applications from a set of tools, and creating those tools. There are several "reuse" projects, which focus on the problems of identifying and cataloging tools. NAO is directed at the specific context of scientific computing. Because the type of tools is restricted, problems such as tools with incompatible data structures for input and output, and dissimilar interfaces to tools which solve similar problems can be addressed. The approach we've taken is to define interfaces to those objects used in numerical analysis, such as geometries, functions and operators, and to start collecting (and building) a set of tools which use these interfaces. We have written a class library (a set of abstract classes and implementations) in C++ which demonstrates the approach. Besides the classes, the class library includes "stub" routines which allow the library to be used from C or Fortran, and an interface to a Visual Programming Language. The library has been used to build a simulator for petroleum reservoirs, using a set of tools for discretizing nonlinear differential equations that we have written, and includes "wrapped" versions of packages from the Netlib repository. Documentation can be found on the Web at "http://www.research.ibm.com/nao". I will describe the objects and their interfaces, and give examples ranging from mesh generation to solving differential equations.

Large-scale Controls on Atlantic Tropical Cyclone Activity on Seasonal Time Scales

PubMed Central

Lim, Young-Kwon; Schubert, Siegfried D.; Reale, Oreste; Molod, Andrea M.; Suarez, Max J.; Auer, Benjamin M.

2018-01-01

Interannual variations in seasonal tropical cyclone (TC) activity (e.g., genesis frequency and location, track pattern, and landfall) over the Atlantic are explored by employing observationally-constrained simulations with the NASA Goddard Earth Observing System version (GEOS-5) atmospheric general circulation model. The climate modes investigated are El Niño-Southern Oscillation (ENSO), the North Atlantic Oscillation (NAO), and the Atlantic Meridional Mode (AMM). The results show that the NAO and AMM can strongly modify and even oppose the well-known ENSO impacts, like in 2005, when a strong positive AMM (associated with warm SSTs and a negative SLP anomaly over the western tropical Atlantic), led to a very active TC season with enhanced TC genesis over the Caribbean Sea and a number of landfalls over North America, under a neutral ENSO condition. On the other end, the weak TC activity during 2013 (characterized by weak negative Niño index) appears caused by a NAO-induced positive SLP anomaly with enhanced vertical wind shear over the tropical North Atlantic. During 2010, the combined impact of the three modes produced positive SST anomalies across the entire low- latitudinal Atlantic and a weaker subtropical high, leading to more early recurvers and thus fewer landfalls despite enhanced TC genesis. The study provides evidence that TC number and track are very sensitive to the relative phases and intensities of these three modes, and not just to ENSO alone. Examination of seasonal predictability reveals that predictive skill of the three modes is limited over tropics to sub-tropics, with the AMM having the highest predictability over the North Atlantic, followed by ENSO and NAO. PMID:29928071

Interaction of External K, Na, and Cardioactive Steroids with the Na-K Pump of the Human Red Blood Cell

PubMed Central

Sachs, John R.

1974-01-01

The interaction of extracellular Na (Nao), K (Ko), and strophanthidin with the Na-K pump of the human red blood cell has been investigated. Inhibition by submaximal concentrations of strophanthidin rapidly reaches a level which does not increase further over a relatively long period of time. Under these circumstances, it is possible to apply a steady-state kinetic analysis to the interaction of Nao, Ko, and strophanthidin with the pump. In Na-free solutions, strophanthidin increases the apparent K1/2 of the pump for Ko, but does not change the form of the relation between the reciprocal of the active K influx (i M K P–1) and the reciprocal of [Ko] ([Ko]–1); the relation both in the presence and absence of strophanthidin is adequately described by a straight line. In solutions containing Na, strophanthidin changes the form of the curve describing the relation between i M K P–1 vs. [Ko]–1; the curve becomes more parabolic in solutions containing strophanthidin. The rate of ouabain binding to K-free cells has also been measured; in the absence of K, the rate of binding is unaffected by Nao. The data are considered in terms of a simple kinetic model. The findings can be explained if it is supposed that at low external K the form of the pump combined with one Nao is more likely to combine with strophanthidin than is the uncombined form of the pump. The uncombined form of the pump is more likely to combine with K even at very low Ko than with strophanthidin. PMID:4812632

Large-Scale Controls on Atlantic Tropical Cyclone Activity on Seasonal Time Scales

NASA Technical Reports Server (NTRS)

Lim, Young-Kwon; Schubert, Siegfried D.; Reale, Oreste; Molod, Andrea M.; Suarez, Max J.; Auer, Benjamin M.

2016-01-01

Interannual variations in seasonal tropical cyclone (TC) activity (e.g., genesis frequency and location, track pattern, and landfall) over the Atlantic are explored by employing observationally-constrained simulations with the NASA Goddard Earth Observing System version (GEOS-5) atmospheric general circulation model. The climate modes investigated are El Nino-Southern Oscillation (ENSO), the North Atlantic Oscillation (NAO), and the Atlantic Meridional Mode (AMM). The results show that the NAO and AMM can strongly modify and even oppose the well- known ENSO impacts, like in 2005, when a strong positive AMM (associated with warm SSTs and a negative SLP anomaly over the western tropical Atlantic), led to a very active TC season with enhanced TC genesis over the Caribbean Sea and a number of landfalls over North America, under a neutral ENSO condition. On the other end, the weak TC activity during 2013 (characterized by weak negative Nio index) appears caused by a NAO-induced positive SLP anomaly with enhanced vertical wind shear over the tropical North Atlantic. During 2010, the combined impact of the three modes produced positive SST anomalies across the entire low-latitudinal Atlantic and a weaker subtropical high, leading to more early recurvers and thus fewer landfalls despite enhanced TC genesis. The study provides evidence that TC number and track are very sensitive to the relative phases and intensities of these three modes, and not just to ENSO alone. Examination of seasonal predictability reveals that predictive skill of the three modes is limited over tropics to sub-tropics, with the AMM having the highest predictability over the North Atlantic, followed by ENSO and NAO.

Desenvolvimento de modelo clínico para predição da possibilidade de identificação da artéria de Adamkiewicz por angiotomografia

PubMed Central

Amato, Alexandre Campos Moraes; Parga, José Rodrigues; Stolf, Noedir Antônio Groppo

2018-01-01

Resumo Contexto Diferenças morfológicas da artéria de Adamkiewicz (AKA) entre a população portadora e não portadora de doença aórtica têm importância clínica, influenciando as complicações neuroisquêmicas da medula espinhal em procedimentos operatórios. Ainda não é conhecida a correlação entre parâmetros clínicos e a previsibilidade da identificação dessa artéria pela angiotomografia. Objetivo Desenvolver um modelo matemático que, através de parâmetros clínicos correlacionados com aterosclerose, possa prever a probabilidade de identificação da AKA em pacientes submetidos a angiotomografias. Método Estudo observacional transversal utilizando banco de imagens e dados de pacientes. Foi feita análise estatística multivariada e criado modelo matemático logit de predição para identificação da AKA. Variáveis significativas foram utilizadas na montagem da fórmula para cálculo da probabilidade de identificação. O modelo foi calibrado, e a discriminação foi avaliada pela curva receiver operating characteristic (ROC). A seleção das variáveis explanatórias foi guiada pela maior área na curva ROC (p = 0,041) e pela significância combinada das variáveis. Resultados Foram avaliados 110 casos (54,5% do sexo masculino, com idade média de 60,97 anos e etnia com coeficiente B -2,471, M -1,297, N -0,971), com AKA identificada em 60,9%. Índice de massa corporal: 27,06 ± 0,98 (coef. -0,101); fumantes: 55,5% (coef. -1,614/-1,439); diabéticos: 13,6%; hipertensos: 65,5% (coef. -1,469); dislipidêmicos: 58,2%; aneurisma aórtico: 38,2%; dissecção aórtica: 12,7%; e trombo mural: 24,5%. Constante de 6,262. Fórmula para cálculo da probabilidade de detecção: (e−(Coef. Etnia+(Coef. IMC×IMC)+Coef.fumante+Coef.HAS+Coef.dislip+Constante)+1)−1 . O modelo de predição foi criado e disponibilizado no link https://vascular.pro/aka-model . Conclusão Com as covariáveis etnia, índice de massa corporal, tabagismo, hipertens

Identification of Rice Genes Associated With Enhanced Cold Tolerance by Comparative Transcriptome Analysis With Two Transgenic Rice Plants Overexpressing DaCBF4 or DaCBF7, Isolated From Antarctic Flowering Plant Deschampsia antarctica

PubMed Central

Byun, Mi Young; Cui, Li Hua; Lee, Jungeun; Park, Hyun; Lee, Andosung; Kim, Woo Taek; Lee, Hyoungseok

2018-01-01

Few plant species can survive in Antarctica, the harshest environment for living organisms. Deschampsia antarctica is the only natural grass species to have adapted to and colonized the maritime Antarctic. To investigate the molecular mechanism of the Antarctic adaptation of this plant, we identified and characterized D. antarctica C-repeat binding factor 4 (DaCBF4), which belongs to monocot CBF group IV. The transcript level of DaCBF4 in D. antarctica was markedly increased by cold and dehydration stress. To assess the roles of DaCBF4 in plants, we generated a DaCBF4-overexpressing transgenic rice plant (Ubi:DaCBF4) and analyzed its abiotic stress response phenotype. Ubi:DaCBF4 displayed enhanced tolerance to cold stress without growth retardation under any condition compared to wild-type plants. Because the cold-specific phenotype of Ubi:DaCBF4 was similar to that of Ubi:DaCBF7 (Byun et al., 2015), we screened for the genes responsible for the improved cold tolerance in rice by selecting differentially regulated genes in both transgenic rice lines. By comparative transcriptome analysis using RNA-seq, we identified 9 and 15 genes under normal and cold-stress conditions, respectively, as putative downstream targets of the two D. antarctica CBFs. Overall, our results suggest that Antarctic hairgrass DaCBF4 mediates the cold-stress response of transgenic rice plants by adjusting the expression levels of a set of stress-responsive genes in transgenic rice plants. Moreover, selected downstream target genes will be useful for genetic engineering to enhance the cold tolerance of cereal plants, including rice. PMID:29774046

Identification of Rice Genes Associated With Enhanced Cold Tolerance by Comparative Transcriptome Analysis With Two Transgenic Rice Plants Overexpressing DaCBF4 or DaCBF7, Isolated From Antarctic Flowering Plant Deschampsia antarctica.

PubMed

Byun, Mi Young; Cui, Li Hua; Lee, Jungeun; Park, Hyun; Lee, Andosung; Kim, Woo Taek; Lee, Hyoungseok

2018-01-01

Few plant species can survive in Antarctica, the harshest environment for living organisms. Deschampsia antarctica is the only natural grass species to have adapted to and colonized the maritime Antarctic. To investigate the molecular mechanism of the Antarctic adaptation of this plant, we identified and characterized D. antarctica C-repeat binding factor 4 ( DaCBF4 ), which belongs to monocot CBF group IV. The transcript level of DaCBF4 in D. antarctica was markedly increased by cold and dehydration stress. To assess the roles of DaCBF4 in plants, we generated a DaCBF4 -overexpressing transgenic rice plant ( Ubi:DaCBF4 ) and analyzed its abiotic stress response phenotype. Ubi:DaCBF4 displayed enhanced tolerance to cold stress without growth retardation under any condition compared to wild-type plants. Because the cold-specific phenotype of Ubi:DaCBF4 was similar to that of Ubi:DaCBF7 (Byun et al., 2015), we screened for the genes responsible for the improved cold tolerance in rice by selecting differentially regulated genes in both transgenic rice lines. By comparative transcriptome analysis using RNA-seq, we identified 9 and 15 genes under normal and cold-stress conditions, respectively, as putative downstream targets of the two D. antarctica CBFs. Overall, our results suggest that Antarctic hairgrass DaCBF4 mediates the cold-stress response of transgenic rice plants by adjusting the expression levels of a set of stress-responsive genes in transgenic rice plants. Moreover, selected downstream target genes will be useful for genetic engineering to enhance the cold tolerance of cereal plants, including rice.

Biofortification of soybean meal: immunological properties of the 27 kDa γ-zein.

PubMed

Krishnan, Hari B; Jang, Sungchan; Kim, Won-Seok; Kerley, Monty S; Oliver, Melvin J; Trick, Harold N

2011-02-23

Legumes, including soybeans ( Glycine max ), are deficient in sulfur-containing amino acids, which are required for the optimal growth of monogastric animals. This deficiency can be overcome by expressing heterologous proteins rich in sulfur-containing amino acids in soybean seeds. A maize 27 kDa γ-zein, a cysteine-rich protein, has been successfully expressed in several crops including soybean, barley, and alfalfa with the intent to biofortify these crops for animal feed. Previous work has shown that the maize 27 kDa zein can withstand digestion by pepsin and elicit an immunogenic response in young pigs. By use of sera from patients who tested positive by ImmunoCAP assay for elevated IgE to maize proteins, specific IgE binding to the 27 kDa γ-zein is demonstrated. Bioinformatic analysis using the full-length and 80 amino acid sliding window FASTA searches identified significant sequence homology of the 27 kDa γ-zein with several known allergens. Immunoblot analysis using human serum that cross-reacts with maize seed proteins also revealed specific IgE-binding to the 27 kDa γ-zein in soybean seed protein extracts containing the 27 kDa zein. This study demonstrates for the first time the allergenicity potential of the 27 kDa γ-zein and the potential that this protein has to limit livestock performance when used in soybeans that serve as a biofortified feed supplement.

Efficient evaluation of nonlocal operators in density functional theory

NASA Astrophysics Data System (ADS)

Chen, Ying-Chih; Chen, Jing-Zhe; Michaud-Rioux, Vincent; Shi, Qing; Guo, Hong

2018-02-01

We present a method which combines plane waves (PW) and numerical atomic orbitals (NAO) to efficiently evaluate nonlocal operators in density functional theory with periodic boundary conditions. Nonlocal operators are first expanded using PW and then transformed to NAO so that the problem of distance-truncation is avoided. The general formalism is implemented using the hybrid functional HSE06 where the nonlocal operator is the exact exchange. Comparison of electronic structures of a wide range of semiconductors to a pure PW scheme validates the accuracy of our method. Due to the locality of NAO, thus sparsity of matrix representations of the operators, the computational complexity of the method is asymptotically quadratic in the number of electrons. Finally, we apply the technique to investigate the electronic structure of the interface between a single-layer black phosphorous and the high-κ dielectric material c -HfO2 . We predict that the band offset between the two materials is 1.29 eV and 2.18 eV for valence and conduction band edges, respectively, and such offsets are suitable for 2D field-effect transistor applications.

Cycles in oceanic teleconnections and global temperature change

NASA Astrophysics Data System (ADS)

Seip, Knut L.; Grøn, Øyvind

2018-06-01

Three large ocean currents are represented by proxy time series: the North Atlantic Oscillation (NAO), the Southern Oscillation Index (SOI), and the Pacific Decadal Oscillation (PDO). We here show how proxies for the currents interact with each other and with the global temperature anomaly (GTA). Our results are obtained by a novel method, which identifies running average leading-lagging (LL) relations, between paired series. We find common cycle times for a paired series of 6-7 and 25-28 years and identify years when the LL relations switch. Switching occurs with 18.4 ± 14.3-year intervals for the short 6-7-year cycles and with 27 ± 15-year intervals for the 25-28-year cycles. During the period 1940-1950, the LL relations for the long cycles were circular (nomenclature x leads y: x → y): GTA → NAO → SOI → PDO → GTA. However, after 1960, the LL relations become more complex and there are indications that GTA leads to both NAO and PDO. The switching years are related to ocean current tie points and reversals reported in the literature.

North Atlantic Oscillation Drives Regional Greenland Glacier Volume During the 20th Century

NASA Astrophysics Data System (ADS)

Bjork, A. A.; Aagaard, S.; Hallander, A. M.; Khan, S. A.; Box, J. E.; Kjeldsen, K. K.; Larsen, N. K.; Korsgaard, N. J.; Cappelen, J.; Colgan, W. T.; Machguth, H.; Andresen, C. S.; Kjaer, K. H.

2016-12-01

While most areas of the Greenland ice sheet have undergone rapid mass loss since c. 1990, the central eastern section of the ice sheet has advanced and gained mass. This contrasting regional trend has been attributed to positive surface mass balance (SMB) in the absence of significant dynamic mass loss. To constrain the atypical behavior in this region, we mapped glacier length fluctuations of nearly 200 peripheral glaciers and ice caps (PGICs) over a 103-year period, and compare the results with c. 150 new glacier length records from central west Greenland. We demonstrate that the regional response in ice volume is closely correlated to changes in precipitation, governed by circulation patterns associated with the North Atlantic Oscillation (NAO) and secondarily influenced by temperature forcing in certain periods. More broadly, we find that the NAO contributes to contrasting precipitation variability in East and West Greenland, where it appears to be responsible for at least 10% and more than 25%, respectively, of the variability in ice sheet accumulation rate. This east-west asymmetry, which influences both LGICs and the ice sheet, illustrates how substantial uncertainty in NAO projections directly contributes to uncertainty in mass balance projections.

Recruitment success of different fish stocks in the North Sea in relation to climate variability

NASA Astrophysics Data System (ADS)

Dippner, Joachim W.

1997-09-01

Long-term data of year class strengths of different commercially harvested fish stocks based on a virtual population analysis (VPA) are available from ICES. The anomalies of these long-term data sets of year class strength are analyzed using Empirical Orthogonal Functions (EOFs) and are related to climate variability: the anomalies of the sea surface temperature (SST) in the northern North Sea and the North Atlantic Oscillation (NAO) index. A Canonical Correlation Analysis (CCA) between the leading eigenmodes is performed. The results suggest that the variability in the fish recruitment of western mackerel and three gadoids, namely North Sea cod, North Sea saithe, and North Sea whiting is highly correlated to the variability of the North Sea SST which is directly influenced by the NAO. For North Sea haddock and herring no meaningful correlation exists to North Sea SST and NAO. The results allow the conclusion that is seems possible to predict long-term changes in the fish recruitment from climate change scenarios for North Sea cod, North Sea saithe and western mackerel. Furthermore, the results indicate the possibility of recruitment failure for North Sea cod, North Sea whiting, and western mackerel in the case of global warming.

Early experience using the da Vinci Surgical System for the treatment of mediastinal tumors.

PubMed

Kajiwara, Naohiro; Taira, Masahiro; Yoshida, Koichi; Hagiwara, Masaru; Kakihana, Masatoshi; Usuda, Jitsuo; Uchida, Osamu; Ohira, Tatsuo; Kawate, Norihiko; Ikeda, Norihiko

2011-10-01

The da Vinci Surgical System has been used in only a few cases for treating mediastinal tumors in Japan. Recently, we used the da Vinci Surgical System for various types of anterior and middle mediastinal tumors in clinical practice. We report our early experience using the da Vinci Surgical System. Seven patients gave written informed consent to undergo robotic surgery for mediastinal tumor dissection using the da Vinci Surgical System. We evaluated the safety and feasibility of this system for the surgical treatment of mediastinal tumors. Two specialists in thoracic surgery who are certified to use the da Vinci S Surgical System and another specialist acted as an assistant performed the tumor dissection. We were able to access difficult-to-reach areas, such as the mediastinum, safely. All the resected tumors were classified as benign tumors histologically. The average da Vinci setting time was 14.0 min, the average working time was 55.7 min, and the average overall operating time was 125.9 min. The learning curve for the da Vinci setup and manipulation time was short. Robotic surgery enables mediastinal tumor dissection in certain cases more safely and easily than conventional video-assisted thoracoscopic surgery and less invasively than open thoracotomy.

Cloning and functional characterization of the DA2 receptor gene in Chinese mitten crab (Eriocheir sinensis)

PubMed Central

Xu, Min-jie; Zhang, Cong; Yang, Zhigang

2018-01-01

Dopamine (DA) plays a modulatory role in numerous physiological processes such as light adaptation and food intake, and exerts these functions through DA receptors (DARs). This study presents, for the first time, isolation and characterization of the dopamine receptor 2(DA2 receptor) cDNA from the intestinal tissue of Eriocheir sinensis, an economically important freshwater aquaculture species in China. The DA2 receptor cDNA sequence, which was obtained by rapid amplification of cDNA ends, is 2369bp long, encode peptide of 589 amino acid, and is highly homologous to related sequences in crustaceans. Analysis of the deduced amino acid sequence and the structure of the DA2 indicated that this receptor is a member of the family of G protein-coupled receptors (GPCRs), as it contains seven transmembrane domains and other common signatures of GPCRs. RT-PCR showed that the expression of the DA2 receptor gene was distributed in various tissues, and high expression levels were observed in the cranial ganglia and the thoracic ganglia. Further study of the effect of photoperiod on DA2 expression showed that constant darkness induced a significant increase in DA2 expression in the cranial ganglia. Finally, analysis of DA2 receptor expression under different feeding statuses showed that there was significantly greater expression in the hepatopancreas and intestines after feeding than before feeding, but there were no differences in expression between the before feeding and during feeding periods in either tissue. Our results indicate that the DA2 receptor structurally belongs to the family of G protein-coupled receptors, and that the cranial ganglia are the main tissues in which the DA2 receptor participates in light adaptation during dark hours. In addition, the DA2 receptor in E. sinensis may be involved in the physiological regulation of the hepatopancreas and digestive tract after the ingestion of food. This study provides a foundation for further exploration of the light

DaMab-2: Anti-Human DGKα Monoclonal Antibody for Immunocytochemistry.

PubMed

Nakano, Tomoyuki; Ogasawara, Satoshi; Tanaka, Toshiaki; Hozumi, Yasukazu; Mizuno, Satoru; Satoh, Eri; Sakane, Fumio; Okada, Naoki; Taketomi, Akinobu; Honma, Ryusuke; Nakamura, Takuro; Saidoh, Noriko; Yanaka, Miyuki; Itai, Shunsuke; Handa, Saori; Chang, Yao-Wen; Yamada, Shinji; Kaneko, Mika K; Kato, Yukinari; Goto, Kaoru

2017-08-01

Diacylglycerol kinase (DGK) is responsible for the enzymatic conversion of diacylglycerol to phosphatidic acid. Since both diacylglycerol and phosphatidic acid serve as signaling molecules, DGK is regarded as a hub between diacylglycerol-mediated and phosphatidic acid-mediated signaling. One of the 10 DGK isozymes, DGKα, is shown to be involved in T cell function. Transfection studies using tagged expression vectors revealed that DGKα localizes to the cytoplasm and nucleus and translocates to the plasma membrane in response to T cell receptor stimulation. However, a limited number of studies reported the localization of native protein of DGKα in tissues and cells. In this study, we immunized mice with recombinant DGKα and developed several anti-DGKα monoclonal antibodies (mAbs). One of the established anti-DGKα mAbs is a clone DaMab-2 (mouse IgG 1 , kappa). In enzyme-linked immunosorbent assay, DaMab-2 recognized only DGKα, and did not react with the other isozymes, such as DGKγ, DGKζ, DGKη, and DGKδ. Importantly, DaMab-2 is very useful in immunocytochemical analysis of human cultured cells, indicating that DaMab-2 is advantageous to analyze the localization and function of DGKα.

DA-9701: A New Multi-Acting Drug for the Treatment of Functional Dyspepsia

PubMed Central

Kwon, Yong Sam; Son, Miwon

2013-01-01

Motilitone® (DA-9701) is a new herbal drug that was launched for the treatment of functional dyspepsia in December 2011 in Korea. The heterogeneous symptom pattern and multiple causes of functional dyspepsia have resulted in multiple drug target strategies for its treatment. DA-9701, a compound consisting of a combination of Corydalis Tuber and Pharbitidis Semen, has being developed for treatment of functional dyspepsia. It has multiple mechanisms of action such as fundus relaxation, visceral analgesia, and prokinetic effects. Furthermore, it was found to significantly enhance meal-induced gastric accommodation and increase gastric compliance in dogs. DA-9701 also showed an analgesic effect in rats with colorectal distension induced visceral hypersensitivity and an antinociceptive effect in beagle dogs with gastric distension-induced nociception. The pharmacological effects of DA-9701 also include conventional effects, such as enhanced gastric emptying and gastrointestinal transit. The safety profi le of DA-9701 is also preferable to that of other treatments. PMID:24265862

Winter Precipitation in North America and the Pacific-North America Pattern in GEOS-S2Sv2 Seasonal Hindcast

NASA Technical Reports Server (NTRS)

Li, Zhao; Molod, Andrea; Schubert, Siegfried

2018-01-01

Reliable prediction of precipitation remains one of the most pivotal and complex challenges in seasonal forecasting. Previous studies show that various large-scale climate modes, such as ENSO, PNA and NAO play significant role in winter precipitation variability over the Northern America. The influences are most pronounced in years of strong indices of such climate modes. This study evaluates model bias, predictability and forecast skills of monthly winter precipitation in GEOS5-S2S 2.0 retrospective forecast from 1981 to 2016, with emphasis on the forecast skill of precipitation over North America during the extreme events of ENSO, PNA and NAO by applying EOF and composite analysis.

DA-9701 on gastric motility in patients with Parkinson's disease: A randomized controlled trial.

PubMed

Shin, Cheol Min; Lee, Yoon Jin; Kim, Jong-Min; Lee, Jee Young; Kim, Kyung-Joon; Choi, Yoon Jin; Kim, Nayoung; Lee, Dong Ho

2018-04-21

To evaluate the effect of DA-9701, a novel prokinetic drug, on gastric motility evaluated by magnetic resonance imaging in patients with Parkinson's disease (PD). Forty PD patients were randomly allocated to receive either domperidone or DA-9701. Their gastric functions were evaluated using magnetic resonance imaging before and after 4-week treatment period. Information on levodopa daily dose, disease duration, and Unified PD Rating Scale scores was collected. In 18 patients (domperidone: 9, DA-9701: 9), plasma levodopa concentrations were determined. Primary outcome was assessed by a one-sided 95% confidence interval to show non-inferiority of DA-9701 vs. domperidone with a pre-determined non-inferiority margin of -10%. Thirty-eight participants (19 men and 19 women; mean age, 67.1 years) completed the study protocol (domperidone: DA-9701 = 19:19). Gastric emptying rate at 120 min (2-hr GER) was comparable between the 2 groups; it was not correlated with levodopa daily dose or disease duration or Unified PD Rating Scale scores (all p > 0.05). DA-9701 was not inferior to domperidone in changes of 2-hr GERs before and after the treatment (absolute difference, 4.0 %; one-sided 95% confidence interval, - 3.7 to infinity). However, a significant increase in 2-hr GER was observed only in DA-9701 group (54.5% and 61.8%, before and after treatment, respectively, p < 0.05). Plasma levodopa concentration showed an insignificant but increasing trend in DA-9701 group. There were neither adverse reactions nor deteriorations of parkinsonian symptoms observed in the study participants. DA-9701 can be used for the patients with PD to enhance gastric motility without aggravating PD symptoms (ClinicalTrials.gov number: NCT03022201). Copyright © 2018 Elsevier Ltd. All rights reserved.

PanDA Pilot Submission using Condor-G: Experience and Improvements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhao X.; Hover John; Wlodek Tomasz

2011-01-01

PanDA (Production and Distributed Analysis) is the workload management system of the ATLAS experiment, used to run managed production and user analysis jobs on the grid. As a late-binding, pilot-based system, the maintenance of a smooth and steady stream of pilot jobs to all grid sites is critical for PanDA operation. The ATLAS Computing Facility (ACF) at BNL, as the ATLAS Tier1 center in the US, operates the pilot submission systems for the US. This is done using the PanDA 'AutoPilot' scheduler component which submits pilot jobs via Condor-G, a grid job scheduling system developed at the University of Wisconsin-Madison.more » In this paper, we discuss the operation and performance of the Condor-G pilot submission at BNL, with emphasis on the challenges and issues encountered in the real grid production environment. With the close collaboration of Condor and PanDA teams, the scalability and stability of the overall system has been greatly improved over the last year. We review improvements made to Condor-G resulting from this collaboration, including isolation of site-based issues by running a separate Gridmanager for each remote site, introduction of the 'Nonessential' job attribute to allow Condor to optimize its behavior for the specific character of pilot jobs, better understanding and handling of the Gridmonitor process, as well as better scheduling in the PanDA pilot scheduler component. We will also cover the monitoring of the health of the system.« less

Effect of DA-8031, a novel oral compound for premature ejaculation, on male rat sexual behavior.

PubMed

Kang, Kyung Koo; Sung, Ji Hyun; Kim, Soon Hoe; Lee, Sukhyang

2014-03-01

DA-8031 is a potent and selective serotonin transporter inhibitor developed for the treatment of premature ejaculation. The aim of the present study was to investigate the effects of DA-8031 on male sexual behavior in a rat model. Sexual behavior was examined after an acute oral administration of 10, 30 or 100 mg/kg of DA-8031 in copulation studies with female rats. Pharmacokinetic parameters were calculated after oral administration of DA-8031 at a dose level of 30 mg/kg. DA-8031 treatment produced a dose-dependent increase in ejaculation latency time and showed statistical significance at 30 and 100 mg/kg dosage levels compared with the vehicle (P < 0.05). In addition, DA-8031 treatment reduced the mean number of ejaculations in a dose-dependent manner. No changes in post-ejaculatory interval, numbers of mounts, intromissions or ejaculations were observed at any dose. In pharmacokinetic study, the blood concentration of DA-8031 peaked at 0.38 ± 0.14 h after oral administration, and then rapidly declined with a half-life of 1.79 ± 0.32 h. Treatment with DA-8031 delays the ejaculation latency time without affecting the initiation of mounting behavior or post-ejaculatory interval in rats. Furthermore, DA-8031 is rapidly absorbed and eliminated after oral administration in rats. These preclinical findings provide a clue for the clinical testing of DA-8031 as an "on-demand" agent for premature ejaculation. © 2013 The Japanese Urological Association.

Cloning, expression and activation of a truncated 92-kDa gelatinase minienzyme.

PubMed

Kröger, M; Tschesche, H

1997-09-01

The matrix metalloproteinases (MMPs) are a family of highly homologous zinc-endopeptidases that degrade extracellular matrix components. Human 92-kDa gelatinase (MMP-9) represents one of the MMPs that cleaves native collagen type IV. As a basis for structural investigations, the short form (catalytic domain, amino acid residues 113-450) of the 92-kDa gelatinase cDNA was cloned and expressed in E. coli as a minienzyme. By combination of reverse transcription (RT) and polymerase chain reaction (PCR), the truncated 92-kDa gelatinase-cDNA was amplified from the corresponding mRNA derived from ovarian carcinoma cells. The cDNA fragment obtained was cloned in E. coli and sequenced. With the exception of one nucleotide inversion at position 745 (gt-->tg) the cDNA sequence was identical to the nucleotide sequence of the 92-kDa gelatinase as has been previously reported. The protein was expressed in E. coli using the vector pET-12b. The recombinant protein was stored in inclusion bodies and extracted as a 38 kDa species from the inclusion bodies by solubilization in 8 M urea. The product was purified by affinity chromatography and gel filtration. Amino-terminal sequence analysis confirmed the identity with the catalytic domain of 92-kDa gelatinase. The recombinant protein was refolded in the presence of Ca2+ and Zn2+ and yielded an active minienzyme with gelatinolytic activity. It degrades the native substrate collagen type IV and the synthetic substrate Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 x AcOH like the full-length 92-kDa gelatinase. The catalytic activity could be inhibited by the specific MMP inhibitors TIMP-1 and TIMP-2.

Morphogenetic Studies of the Drosophila DA1 Ventral Olfactory Projection Neuron

PubMed Central

Yu, Hung-Hsiang

2016-01-01

In the Drosophila olfactory system, odorant information is sensed by olfactory sensory neurons and relayed from the primary olfactory center, the antennal lobe (AL), to higher olfactory centers via olfactory projection neurons (PNs). A major portion of the AL is constituted with dendrites of four groups of PNs, anterodorsal PNs (adPNs), lateral PNs (lPNs), lateroventral PNs (lvPNs) and ventral PNs (vPNs). Previous studies have been focused on the development and function of adPNs and lPNs, while the investigation on those of lvPNs and vPNs received less attention. Here, we study the molecular and cellular mechanisms underlying the morphogenesis of a putative male-pheromone responding vPN, the DA1 vPN. Using an intersection strategy to remove background neurons labeled within a DA1 vPN-containing GAL4 line, we depicted morphological changes of the DA1 vPN that occurs at the pupal stage. We then conducted a pilot screen using RNA interference knock-down approach to identify cell surface molecules, including Down syndrome cell adhesion molecule 1 and Semaphorin-1a, that might play essential roles for the DA1 vPN morphogenesis. Taken together, by revealing molecular and cellular basis of the DA1 vPN morphogenesis, we should provide insights into future comprehension of how vPNs are assembled into the olfactory neural circuitry. PMID:27163287

Morphogenetic Studies of the Drosophila DA1 Ventral Olfactory Projection Neuron.

PubMed

Shen, Hung-Chang; Wei, Jia-Yi; Chu, Sao-Yu; Chung, Pei-Chi; Hsu, Tsai-Chi; Yu, Hung-Hsiang

2016-01-01

In the Drosophila olfactory system, odorant information is sensed by olfactory sensory neurons and relayed from the primary olfactory center, the antennal lobe (AL), to higher olfactory centers via olfactory projection neurons (PNs). A major portion of the AL is constituted with dendrites of four groups of PNs, anterodorsal PNs (adPNs), lateral PNs (lPNs), lateroventral PNs (lvPNs) and ventral PNs (vPNs). Previous studies have been focused on the development and function of adPNs and lPNs, while the investigation on those of lvPNs and vPNs received less attention. Here, we study the molecular and cellular mechanisms underlying the morphogenesis of a putative male-pheromone responding vPN, the DA1 vPN. Using an intersection strategy to remove background neurons labeled within a DA1 vPN-containing GAL4 line, we depicted morphological changes of the DA1 vPN that occurs at the pupal stage. We then conducted a pilot screen using RNA interference knock-down approach to identify cell surface molecules, including Down syndrome cell adhesion molecule 1 and Semaphorin-1a, that might play essential roles for the DA1 vPN morphogenesis. Taken together, by revealing molecular and cellular basis of the DA1 vPN morphogenesis, we should provide insights into future comprehension of how vPNs are assembled into the olfactory neural circuitry.

The climate of the Common Era off the Iberian Peninsula

NASA Astrophysics Data System (ADS)

Abrantes, Fátima; Rodrigues, Teresa; Rufino, Marta; Salgueiro, Emília; Oliveira, Dulce; Gomes, Sandra; Oliveira, Paulo; Costa, Ana; Mil-Homens, Mário; Drago, Teresa; Naughton, Filipa

2017-12-01

The Mediterranean region is a climate hot spot, sensitive not only to global warming but also to water availability. In this work we document major temperature and precipitation changes in the Iberian Peninsula and margin during the last 2000 years and propose an interplay of the North Atlantic internal variability with the three atmospheric circulation modes (ACMs), (North Atlantic Oscillation (NAO), east atlantic (EA) and Scandinavia (SCAND)) to explain the detected climate variability. We present reconstructions of sea surface temperature (SST derived from alkenones) and on-land precipitation (estimated from higher plant n-alkanes and pollen data) in sedimentary sequences recovered along the Iberian Margin between the south of Portugal (Algarve) and the northwest of Spain (Galiza) (36 to 42° N). A clear long-term cooling trend, from 0 CE to the beginning of the 20th century, emerges in all SST records and is considered to be a reflection of the decrease in the Northern Hemisphere summer insolation that began after the Holocene optimum. Multi-decadal/centennial SST variability follows other records from Spain, Europe and the Northern Hemisphere. Warm SSTs throughout the first 1300 years encompass the Roman period (RP), the Dark Ages (DA) and the Medieval Climate Anomaly (MCA). A cooling initiated at 1300 CE leads to 4 centuries of colder SSTs contemporary with the Little Ice Age (LIA), while a climate warming at 1800 CE marks the beginning of the modern/Industrial Era. Novel results include two distinct phases in the MCA: an early period (900-1100 years) characterized by intense precipitation/flooding and warm winters but a cooler spring-fall season attributed to the interplay of internal oceanic variability with a positive phase in the three modes of atmospheric circulation (NAO, EA and SCAND). The late MCA is marked by cooler and relatively drier winters and a warmer spring-fall season consistent with a shift to a negative mode of the SCAND. The Industrial Era

Revisiting shape selectivity in liquid chromatography for polycyclic aromatic hydrocarbons (PAHs) - six-ring and seven-ring Cata-condensed PAH isomers of molecular mass 328 Da and 378 Da.

PubMed

Oña-Ruales, Jorge O; Sander, Lane C; Wilson, Walter B; Wise, Stephen A

2018-01-01

The relationship of reversed-phase liquid chromatography (RPLC) retention on a polymeric C 18 stationary phase and the shape of polycyclic aromatic hydrocarbons (PAHs) was investigated for three-ring to seven-ring cata-condensed isomers. We report the first RPLC separation for six-ring and seven-ring cata-condensed PAH isomers. Correlations of LC retention and shape parameters (length-to-breath ratio, L/B and thickness, T) were investigated for 2 three-ring isomers (molecular mass 178 Da), 5 four-ring isomers (molecular mass 228 Da), 11 five-ring isomers (molecular mass 278 Da), 17 six-ring isomers (molecular mass 328 Da), and 20 seven-ring isomers (molecular mass 378 Da). Significant linear correlations were found for all isomer groups (r = 0.71 to 0.94). Nonplanarity of the PAH isomers was found to influence retention (i.e., nonplanar isomers eluting earlier than expected based on L/B) and linear correlations of retention vs. T for isomer groups containing nonplanar isomers were significant (r = 0.71 to 0.86). Graphical abstract.

Reduced striatal dopamine DA D2 receptor function in dominant-negative GSK-3 transgenic mice.

PubMed

Gomez-Sintes, Raquel; Bortolozzi, Analia; Artigas, Francesc; Lucas, José J

2014-09-01

Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase with constitutive activity involved in cellular architecture, gene expression, cell proliferation, fate decision and apoptosis, among others. GSK-3 expression is particularly high in brain where it may be involved in neurological and psychiatric disorders such as Alzheimer׳s disease, bipolar disorder and major depression. A link with schizophrenia is suggested by the antipsychotic drug-induced GSK-3 regulation and by the involvement of the Akt/GSK-3 pathway in dopaminergic neurotransmission. Taking advantage of the previous development of dominant negative GSK-3 transgenic mice (Tg) showing a selective reduction of GSK-3 activity in forebrain neurons but not in dopaminergic neurons, we explored the relationship between GSK-3 and dopaminergic neurotransmission in vivo. In microdialysis experiments, local quinpirole (DA D2-R agonist) in dorsal striatum reduced dopamine (DA) release significantly less in Tg mice than in wild-type (WT) mice. However, local SKF-81297 (selective DA D1-R agonist) in dorsal striatum reduced DA release equally in both control and Tg mice indicating a comparable function of DA D1-R in the direct striato-nigral pathway. Likewise, systemic quinpirole administration - acting preferentially on presynaptic DA D2- autoreceptors to modulate DA release-reduced striatal DA release similarly in both control and Tg mice. Quinpirole reduced locomotor activity and induced c-fos expression in globus pallidus (both striatal DA D2-R-mediated effects) significantly more in WT than in Tg mice. Taking together, the present results show that dominant negative GSK-3 transgenic mice show reduced DA D2-R-mediated function in striatum and further support a link between dopaminergic neurotransmission and GSK-3 activity. Copyright © 2014 Elsevier B.V. and ECNP. All rights reserved.

A relevant IgE-reactive 28kDa protein identified from Salsola kali pollen extract by proteomics is a natural degradation product of an integral 47kDa polygalaturonase.

PubMed

Mas, Salvador; Oeo-Santos, Carmen; Cuesta-Herranz, Javier; Díaz-Perales, Araceli; Colás, Carlos; Fernández, Javier; Barber, Domingo; Rodríguez, Rosalía; de Los Ríos, Vivian; Barderas, Rodrigo; Villalba, Mayte

2017-08-01

A highly prevalent IgE-binding protein band of 28kDa is observed when Salsola kali pollen extract is incubated with individual sera from Amaranthaceae pollen sensitized patients. By an immunoproteomic analysis of S. kali pollen extract, we identified this protein band as an allergenic polygalacturonase enzyme. The allergen, named Sal k 6, exhibits a pI of 7.14 and a molecular mass of 39,554.2Da. It presents similarities to Platanaceae, Poaceae, and Cupressaceae allergenic polygalacturonases. cDNA-encoding sequence was subcloned into the pET41b vector and produced in bacteria as a His-tag fusion recombinant protein. The far-UV CD spectrum determined that rSal k 6 was folded. Immunostaining of the S. kali pollen protein extract with a rSal k 6-specific pAb and LC-MS/MS proteomic analyses confirmed the co-existence of the 28kDa band together with an allergenic band of about 47kDa in the pollen extract. Therefore, the 28kDa was assigned as a natural degradation product of the 47kDa integral polygalacturonase. The IgE-binding inhibition to S. kali pollen extract using rSal k 6 as inhibitor showed that signals directed to both protein bands of 28 and 47kDa were completely abrogated. The average prevalence of rSal k 6 among the three populations analyzed was 30%, with values correlating well with the levels of grains/m 3 of Amaranthaceae pollen. Sal k 6 shares IgE epitopes with Oleaceae members (Fraxinus excelsior, Olea europaea and Syringa vulgaris), with IgE-inhibition values ranging from 20% to 60%, respectively. No IgE-inhibition was observed with plant-derived food extracts. Copyright © 2017 Elsevier B.V. All rights reserved.

Geomagnetic observations on tristan da cunha, south atlantic ocean

USGS Publications Warehouse

Matzka, J.; Olsen, N.; Maule, C.F.; Pedersen, L.W.; Berarducci, A.M.; Macmillan, S.

2009-01-01

Few geomagnetic ground observations exist of the Earth's strongest core field anomaly, the South Atlantic Anomaly (SAA). The geomagnetic repeat station on the island Tristan da Cunha, located half-way between South Africa and South America at 37?? 05' S, 12?? 18' W, is therefore of crucial importance. We have conducted several sets of repeat station measurements during magnetically quiet conditions (Kp 2o or less) in 2004. The procedures are described and the results are compared to those from earlier campaigns and to the predictions of various global field models. Features of the local crustal bias field and the solar quiet daily variation are discussed. We also evaluate the benefit of continuous magnetic field recordings from Tristan da Cunha, and argue that such a data set is a very valuable addition to geomagnetic satellite data. Recently, funds were set up to establish and operate a magnetometer station on Tristan da Cunha during the Swarm magnetic satellite mission (2011-2014).

Effects of omeprazole or cola beverage on the pharmacokinetics of oral DA-8159, a new erectogenic, in rats.

PubMed

Lee, Joo H; Bae, Soo K; Kwon, Jong W; Kim, Won B; Lee, Myung G

2005-12-01

The changes in pharmacokinetics of DA-8159 by omeprazole with respect to inhibition of CYP3A1/2 in rats were evaluated. After oral administration of DA-8159 at dose of 30 mg/kg to rats pretreated with oral omeprazole at 30 mg/kg for 1 week, the total area under the plasma concentration-time curve from time zero to time infinity (AUC) of DA-8159 was significantly greater (37.5% increase) than that in control rats. This could be due to inhibition of metabolism of DA-8159 by inhibition of CYP3A1/2 by omeprazole. The AUC(DA-8164 (a metabolite of DA-8159))/AUC(DA-8159) ratio was also smaller (32.4% decrease) with omeprazole. After oral administration of DA-8159 at a dose of 30 mg/kg to rats without or with cola beverage, the pharmacokinetic parameters of DA-8159 and DA-8164 were not significantly different between two groups of rats. This suggested that cola beverage did not have any considerable effects on CYP3A1/2 in rats.

Using iPSC-derived human DA neurons from opioid-dependent subjects to study dopamine dynamics.

PubMed

Sheng, Yang; Filichia, Emily; Shick, Elizabeth; Preston, Kenzie L; Phillips, Karran A; Cooperman, Leslie; Lin, Zhicheng; Tesar, Paul; Hoffer, Barry; Luo, Yu

2016-08-01

The dopaminergic (DA) system plays important roles in addiction. However, human DA neurons from drug-dependent subjects were not available for study until recent development in inducible pluripotent stem cells (iPSCs) technology. In this study, we produced DA neurons differentiated using iPSCs derived from opioid-dependent and control subjects carrying different 3' VNTR (variable number tandem repeat) polymorphism in the human dopamine transporter (DAT or SLC6A3). In addition, the effects of valproic acid (VPA) exposures on iPSC-derived human DA neurons are also examined. We present the first evidence suggesting that the 3' VNTR polymorphism in the hDAT gene affects DAT expression level in iPSC-derived human DA neurons. In human DA neurons, which provide an appropriate cellular milieu, VPA treatment alters the expression of several genes important for dopaminergic neuron function including DAT, Nurr1, and TH; this might partly explain its action in regulating addictive behaviors. VPA treatment also significantly increased DA D2 receptor (Drd2) expression, especially in the opioid-dependent iPSC cell lines. Our data suggest that human iPSC-derived DA neurons may be useful in in vitro experimental model to examine the effects of genetic variation in gene regulation, to examine the underlying mechanisms in neurological disorders including drug addiction, and to serve as a platform for therapeutic development.

Seeking 'energy' vs. pain relief in spas in Brazil (Caldas da Imperatriz) and Portugal (Termas da Sulfurea).

PubMed

Quintela, Maria Manuel

2011-04-01

This paper is a comparative ethnography of the therapeutic practices at two different spa locations: Caldas da Imperatriz, SC, Brazil, and Termas da Sulfurea in Cabeco de Vide, Portugal. The comparison reveals the existence of contrasting 'explanatory models' held by the spa-goers as well as by the official medical systems. In the Portuguese context this model is highly medicalized; in the Brazilian case, spa treatments are viewed as 'alternative' or 'complementary' therapy and are also related to religious philosophies. Each model corresponds to a different idiom expressing certain experiences and world views, one focusing on 'pains' (dores) and the other on 'energy' (energia), the former leading to the rationale of 'curing', the latter to the notion of 'energizing'. In this paper the author intends to analyze and contrast the categories found in these models, which originate from different conceptions of health, illness and healing for Brazilian and Portuguese spa-goers.

DA-6034-induced mucin secretion via Ca2+-dependent pathways through P2Y receptor stimulation.

PubMed

Lee, Hun; Kim, Eung Kweon; Kim, Ji Yeon; Yang, Yu-Mi; Shin, Dong Min; Kang, Kyung Koo; Kim, Tae-im

2014-09-11

We evaluated whether DA-6034 is involved in mucin secretion via P2Y receptor activation and/or intracellular Ca2+ concentration ([Ca2+]i) change. Also, we investigated the effect of P2Y receptor inhibitors or Ca2+ chelators on the DA-6034-induced mucin secretion and [Ca2+]i increases. Effects of DA-6034 on mucin expression in primary, cultured, conjunctival epithelial cells was studied using RT-PCR, Western blot analysis, and periodic acid-schiff (PAS) staining. To evaluate thin film layer thickness generated by mucin and fluid secretion, cells were incubated in DA-6034 with/without P2Y antagonists or extracellular/intracellular Ca2+ chelators, and were imaged with confocal microscope using Texas Red-dextran dye. In addition, DA-6034-induced Ca2+-dependent Cl- channels opening was evaluated using perforated patch clamp. Fluo-4/AM was used to measure changes in [Ca2+]i induced by DA-6034 in Ca2+-free or Ca2+-containing buffered condition, as well as P2Y antagonists. DA-6034 induced the expression of mucin genes, production of mucin protein, and increase of number of mucin-secreting cells. P2Y antagonists inhibited DA-6034-induced mucin and fluid secretion, which was also affected by extracellular/intracellular Ca2+ chelators. DA-6034 stimulated Cl- channel opening and [Ca2+]i elevation. Further, [Ca2+]i increases induced by DA-6034 were lacking in either P2Y antagonists or Ca2+-free buffered condition, and diminished when endoplasmic reticulum Ca2+ was depleted by cyclopiazonic acid in Ca2+-free buffered condition. This study demonstrated that DA-6034 has a potential to induce mucin secretion via Ca2+-dependent pathways through P2Y receptors in multilayer, cultured, human conjunctival epithelial cells. Copyright 2014 The Association for Research in Vision and Ophthalmology, Inc.

Assessing the role of Climate Variability in the recent evolution of coastlines in southern Italy

NASA Astrophysics Data System (ADS)

Di Paola, Gianluigi; Atkinson, David; Rosskopf, Carmen M.; Walker, Ian

2016-04-01

During the last century, Climatic Variability (CV) and change effects have generated a discernable impact on the world's coasts, most notably through changes in the frequency and/or magnitude of storm surges, flooding, coastal erosion and sea-level rise. This study explores CV signals and coastal responses along a 36 km stretch of coast in the Molise region of southern Italy on the Central Adriatic Sea. Two dominant signals of CV in the Mediterranean region of Europe are characterized by the North Atlantic Oscillation (NAO) and the East Atlantic-West Russia (EAWR) patterns. The NAO is the leading mode of CV in the North Atlantic region and periods with positive NAO index values are typically associated with above average wind speeds across the mid-latitudes of the Atlantic and western Europe, with anomalously northerly flows across the Mediterranean region and enhanced trade winds over the sub-tropical North Atlantic. Although NAO is one of the most prominent patterns in all seasons, its relative role in regulating the variability of the European climate during non-winter months is not as clear as for the winter season. In contrast, the EAWR exerts strong influence on precipitation in the Mediterranean region such that, during the negative phase of EAWR, wetter conditions prevail across central Europe and the Mediterranean region, with precipitation extremes often occurring during these periods. This study examines the effects of NAO and EAWR on coastline response in the Molise region, which has a microtidal regime (ordinary tidal excursions of 30-40 cm). GIS analysis of shoreline changes from historical aerial photography from 1954-2011 was performed and 20 years (1989-2008) of wave data were analysed from the nearby Ortona buoy to define trends and extreme event occurrence in the wave climate in the study area. Finally, statistical associations between NAO, EAWR, and other CV indices of possible influence (e.g. Arctic Oscillation, Scandinavia Pattern, or the East

Combined influences of seasonal East Atlantic Pattern and North Atlantic Oscillation to excite Atlantic multidecadal variability in a climate model

NASA Astrophysics Data System (ADS)

Ruprich-Robert, Yohan; Cassou, Christophe

2015-01-01

The physical processes underlying the internal component of the Atlantic Multidecadal Variability (AMV) are investigated from a 1,000-yr pre-industrial control simulation of the CNRM-CM5 model. The low-frequency fluctuations of the Atlantic Meridional Overturning Circulation (AMOC) are shown to be the main precursor for the model AMV. The full life cycle of AMOC/AMV events relies on a complex time-evolving relationship with both North Atlantic Oscillation (NAO) and East Atlantic Pattern (EAP) that must be considered from a seasonal perspective in order to isolate their action; the ocean is responsible for setting the multidecadal timescale of the fluctuations. AMOC rise leading to a warm phase of AMV is statistically preceded by wintertime NAO+ and EAP+ from ~Lag -40/-20 yrs. Associated wind stress anomalies induce an acceleration of the subpolar gyre (SPG) and enhanced northward transport of warm and saline subtropical water. Concurrent positive salinity anomalies occur in the Greenland-Iceland-Norwegian Seas in link to local sea-ice decline; those are advected by the Eastern Greenland Current to the Labrador Sea participating to the progressive densification of the SPG and the intensification of ocean deep convection leading to AMOC strengthening. From ~Lag -10 yrs prior an AMOC maximum, opposite relationship is found with the NAO for both summer and winter seasons. Despite negative lags, NAO- at that time is consistent with the atmospheric response through teleconnection to the northward shift/intensification of the Inter Tropical Convergence Zone in link to the ongoing warming of tropical north Atlantic basin due to AMOC rise/AMV build-up. NAO- acts as a positive feedback for the full development of the model AMV through surface fluxes but, at the same time, prepares its termination through negative retroaction on AMOC. Relationship between EAP+ and AMOC is also present in summer from ~Lags -30/+10 yrs while winter EAP- is favored around the AMV peak. Based on

Influence of 120 kDa Pyruvate:Ferredoxin Oxidoreductase on Pathogenicity of Trichomonas vaginalis.

PubMed

Song, Hyun-Ouk

2016-02-01

Trichomonas vaginalis is a flagellate protozoan parasite and commonly infected the lower genital tract in women and men. Iron is a known nutrient for growth of various pathogens, and also reported to be involved in establishment of trichomoniasis. However, the exact mechanism was not clarified. In this study, the author investigated whether the 120 kDa protein of T. vaginalis may be involved in pathogenicity of trichomonads. Antibodies against 120 kDa protein of T. vaginalis, which was identified as pyruvate:ferredoxin oxidoreductase (PFOR) by peptide analysis of MALDI-TOF-MS, were prepared in rabbits. Pretreatment of T. vaginalis with anti-120 kDa Ab decreased the proliferation and adherence to vaginal epithelial cells (MS74) of T. vaginalis. Subcutaneous tissue abscess in anti-120 kDa Ab-treated T. vaginalis-injected mice was smaller in size than that of untreated T. vaginalis-infected mice. Collectively, the 120 kDa protein expressed by iron may be involved in proliferation, adhesion to host cells, and abscess formation, thereby may influence on the pathogenicity of T. vaginalis.

Identification of an abundant 56 kDa protein implicated in food allergy as granule-bound starch synthase

USDA-ARS?s Scientific Manuscript database

Rice, the staple food of South and East Asian counties, is considered to be hypoallergenic. However, several clinical studies have documented rice-induced allergy in sensitive patients. Rice proteins with molecular weights of 14-16 kDa, 26 kDa, 33 kDa and 56 kDa have been identified as allergens. Re...

DaRT: A CALL System to Help Students Practice and Develop Reasoning Skills in Choosing English Articles.

ERIC Educational Resources Information Center

Yoshii, Rika; Milne, Alastair

1998-01-01

Describes DaRT, a computer assisted language-learning system for helping English-as-a-Second-Language students master English articles. DaRT uses a diagrammatic reasoning tool to present communicative contexts for exercises in choosing appropriate articles. This paper describes the development of DaRT and DaRT's system components and concludes…

DA 5505: a novel topical formulation of terbinafine that enhances skin penetration and retention.

PubMed

Thapa, Raj Kumar; Han, Sang-Duk; Park, Hyoung Geun; Son, Miwon; Jun, Joon Ho; Kim, Jong Oh

2015-01-01

Topical fungal infections can become severe if left untreated. Efficient treatment modalities for topical fungal infections aid the penetration of antifungal agents deep into viable skin layers. Terbinafine is a fungicidal agent that inhibits ergosterol, an essential fungal component. The main objective of this study was to evaluate skin permeation and retention of a terbinafine-loaded solution containing chitosan as a film former. Comparative assessment of skin permeation and retention was performed using a prepared formulation (DA 5505) and marketed formulations of terbinafine in murine and porcine skin. To mimic fungal infection of skin, keratinized skin was induced in NC/Nga mice. In comparison with the marketed formulations, DA 5505 exhibited significantly better skin permeation. The flux, permeation coefficient, and enhancement ratio of terbinafine were remarkably increased by DA 5505 in comparison with the marketed formulations, and lag time was dramatically reduced. DA 5505 significantly increased cumulative terbinafine retention in viable skin layers in comparison with the marketed solution, suggesting enhanced efficacy. Furthermore, DA 5505 exhibited superior skin permeation in normal skin and keratinized skin. Thus, the DA 5505 formulation has the potential to effectively deliver terbinafine to superficial and deep cutaneous fungal infections.

Implantable microencapsulated dopamine (DA): prolonged functional release of DA in denervated striatal tissue.

PubMed

McRae, A; Hjorth, S; Mason, D; Dillon, L; Tice, T

1990-01-01

Biodegradable controlled-release microcapsule systems made with the biocompatible biodegradable polyester excipient poly [DL-lactide-co-gly-colide] constitute an exciting new technology for drug delivery to the central nervous system (CNS). The present study describes functional observations indicating that implantation of dopamine (DA) microcapsules encapsulated within two different polymer excipients into denervated striatal tissue assures a prolonged release of the transmitter in vivo. This technology has a considerable potential for basic and possibly clinical research.

Color constrains depth in da Vinci stereopsis for camouflage but not occlusion.

PubMed

Wardle, Susan G; Gillam, Barbara J

2013-12-01

Monocular regions that occur with binocular viewing of natural scenes can produce a strong perception of depth--"da Vinci stereopsis." They occur either when part of the background is occluded in one eye, or when a nearer object is camouflaged against a background surface in one eye's view. There has been some controversy over whether da Vinci depth is constrained by geometric or ecological factors. Here we show that the color of the monocular region constrains the depth perceived from camouflage, but not occlusion, as predicted by ecological considerations. Quantitative depth was found in both cases, but for camouflage only when the color of the monocular region matched the binocular background. Unlike previous reports, depth failed even when nonmatching colors satisfied conditions for perceptual transparency. We show that placing a colored line at the boundary between the binocular and monocular regions is sufficient to eliminate depth from camouflage. When both the background and the monocular region contained vertical contours that could be fused, some observers appeared to use fusion, and others da Vinci constraints, supporting the existence of a separate da Vinci mechanism. The results show that da Vinci stereopsis incorporates color constraints and is more complex than previously assumed.

Ultrasonic irradiation enhanced the ability of Fluorescein-DA-Fe(III) on sonodynamic and sonocatalytic damages of DNA molecules.

PubMed

Wu, Qiong; Chen, Xia; Jia, Lizhen; Wang, Yi; Sun, Ying; Huang, Xingjun; Shen, Yuxiang; Wang, Jun

2017-11-01

The interaction of DNA with Bis [N,N-bis (carboxymethyl) aminomethyl] fluorescein-Ferrous(III) (Fluorescein-DA-Fe(III)) with dual functional (sonodynamic and sonocatalytic) activity was studied by UV-vis spectroscopy, fluorescence spectroscopy, FT-IR spectroscopy, circular dichroism (CD) spectroscopy and viscosity measurements. And then, the damage of DNA caused by Fluorescein-DA-Fe(III) under ultrasonic irradiation (US) was researched by agarose gel electrophoresis and cytotoxicity assay. Meanwhile, some influenced factors such as ultrasonic irradiation time and Fluorescein-DA-Fe(III) concentration on the damage degree of DNA molecules were also examined. As a control, for Bis [N,N-bis (carboxymethyl) aminomethyl] fluorescein (Fluorescein-DA), the same experiments were carried out. The results showed that both Fluorescein-DA-Fe(III) and Fluorescein-DA can interact with DNA molecules. Under ultrasonic irradiation, Fluorescein-DA shows sonodynamic activity, which can damage DNA molecules. While, in the presence of Fe(III) ion, the Fluorescein-DA-Fe(III) displays not only sonodynamic activity but also sonocatalytic activity under ultrasonic irradiation, which injures DNA more serious than Fluorescein-DA. The researches confirmed the dual function (sonodynamic activity and sonocatalytic activity) of Fluorescein-DA-Fe(III) and expanded the usage of Fluorescein-DA-Fe(III) as a sonosensitizer in sonodynamic therapy (SDT). Copyright © 2017 Elsevier B.V. All rights reserved.

Thin films for gas sensors

NASA Astrophysics Data System (ADS)

Pires, Jose Miguel Alves Correia

Nos ultimos anos tem-se assistido a um aumento dos investimentos na investigacao de novos materiais para aplicacao em sensores. Apesar de ja existir um bom numero de dispositivos explorados comercialmente, muitas vezes, quer devido aos elevados custos de producao, quer devido a uma crescente exigencia do ponto de vista das caracteristicas de funcionamento, continua a ser necessario procurar novos materiais ou novas formas de producao que permitam baixar os custos e melhorar o desempenho dos dispositivos. No campo dos sensores de gases tem-se verificado continuos avancos nos ultimos anos. Continua todavia a ser necessario conhecer melhor, tanto os processos de producao dos materiais, como os mecanismos que regulam a sensibilidade dos dispositivos aos gases, de modo a orientar adequadamente a investigacao dos novos materiais, nomeadamente no que se refere a optimizacao dos parâmetros que nao satisfazem ainda os requisitos do mercado. Um dos materiais que tem mostrado melhores qualidades para aplicacao em sensores de gases de tipo resistivo e o dioxido de estanho. Este material tem sido produzido sob diversas formas e usando diferentes tecnicas, como sejam: sol-gel [1], pulverizacao catodica (sputtering) por magnetrao [2-4], sinterizacao de pos [5, 6], ablacao laser [7] ou RGTO [8]. Os resultados obtidos revelam que as caracteristicas dos dispositivos sao muito dependentes das tecnicas usadas na sua producao. A deposicao usando sputtering reactivo por magnetrao e uma tecnica que permite obter filmes finos de oxido de estanho com diferentes caracteristicas, quer do ponto de vista da estrutura, quer da composicao, e por isso, tambem, com diferentes sensibilidades aos gases. No âmbito deste trabalho, foram produzidos filmes de SnO2 usando sputtering DC reactivo com diferentes condicoes de deposicao. Os substratos usados foram lâminas de vidro e o alvo foi estanho com 99.9% de pureza. Foi estudada a influencia da atmosfera de deposicao, da pressao parcial do O2, da

The Indicative and Subjunctive "da"-complements in Serbian A Syntactic-Semantic Approach

ERIC Educational Resources Information Center

Todorovic, Natasa

2012-01-01

A syntactic-semantic investigation of subjunctive and indicative "da"-complements in Serbian is conducted in this project. After a careful comparison of Serbian sentence constructions with "da"-complements to the equivalent sentence structures in languages of the Balkans as well as other Slavic languages, it is clearly…

Sodium/calcium exchange in mammalian ventricular muscle: a study with sodium-sensitive micro-electrodes.

PubMed Central

Chapman, R A; Coray, A; McGuigan, J A

1983-01-01

A method for mounting and rapidly perfusing small ventricular trabeculae (diameter around 250 micron) from either ferret or guinea-pig is described. Tension, membrane potential (Em) and intracellular Na activity (aiNa) were measured. aiNa was measured using Na-sensitive micro-electrodes. At room temperature (22-26 degrees C), [Na]o 155 mmol/l and [Ca]o 5.4 mmol/l, aiNa was 10.9 mmol/l +/- S.D. 4.2 mmol/l (n = 148). When [Na]o was reduced from 155 to 1.5 mmol/l contractures developed. These were about twitch height in guinea-pig but less than the twitch height in ferret. Associated with the development of the contracture there was a decrease in aiNa. The aiNa halved within 30 s. The decrease in aiNa was not influenced by changing pHo from 7.4 to 9.5, K-free solution or strophanthidin 50 mumol/l and was not passive since, even when the [Na]o was 1.5 mmol/l, the driving force for Na ions remained inward. The aiNa decreased if [Ca]o was increased and [Na]o decreased or vice versa. On the basis of these findings it is concluded that the decrease in aiNa is mainly due to Na/Ca exchange. Despite the large decrease in aiNa the [Ca]i, as monitored by tension changes, hardly increased. Since Ca uptake does occur in Na-free conditions in heart muscle it is proposed that the mitochondria take up Ca ions and so prevent an excessive rise in cytoplasmic Ca. Strophanthidin increased both aiNa and the withdrawal contracture, but collected results from a number of experiments showed no clear correlation between the initial aiNa and contracture amplitude. Strophanthidin may, therefore, have actions additional to increasing aiNa. PMID:6644617

pH regulation in barnacle muscle fibers: dependence on extracellular sodium and bicarbonate.

PubMed

Boron, W F; McCormick, W C; Roos, A

1981-01-01

Intracellular pH (pHi) regulation was studied in barnacle muscle fibers with pH-sensitive microelectrodes. The cells were acid loaded, and the subsequent recovery of pHi was monitored. The rate of recovery was reduced by one-third when external Na+ ([Na+]o) was replaced by Li+, but recovery was completely abolished when Na+ was replaced by choline or N-methyl-D-glucamine. In other experiments, varying amounts of Na+ were replaced by choline, and the acid extrusion rate, derived from the recovery rate of pHi, was calculated at a single value of pHi, 6.80. The dependence of the acid extrusion rate on [Na+]o could be described by Michaelis-Menten kinetics; at pHo (extracellular) = 8.0 and [HCO3-]o (extracellular) = 10 mM, the apparent Km and Vmax were 59 mM and 1.3 mmol x l(-1) x min-1. When [HCO3-]o was reduced to 2.5 mM at the same pHo, Km did not change significantly, but Vmax was substantially reduced. On the other hand, when pHo was reduced to 7.4 at constant [HCO3-]o, Vmax changed only slightly, but Km increased substantially. In similar experiments, we examined the dependence of the acid extrusion rate on [HCO3-]o. At pHo = 8.0 and [Na+]o = 440 mM, the apparent Km and Vmax were 4.1 mM and 2.1 mmol x 1-1 x min-1. When pHo was reduced to 7.4, Vmax was not altered, but Km substantially increased. The kinetic data are discussed in terms of the role of pHo, [Na+]o, and [HCO3-]o in the pHi-regulating system.

a Mineralogical Analysis of Hspdp Core Samples from the Northern Awash Pliocene Hadar Formation, Ethiopia: the tale of AN East African Paleolake

NASA Astrophysics Data System (ADS)

Davis, D. M.; Deocampo, D.; Rabideaux, N. M.; Campisano, C. J.

2017-12-01

The Northern Awash Valley is located in the southwestern portion of the Afar Depression in Ethiopia. During the 2014 field season, two core sites were drilled as part of the Hominin Sites and Paleolakes Drilling Project (HSPDP), recovering a total of 600 m of sediment from both localities (NAO and NAW). Mineralogical analyses of the bulk sediments and clays from the Hadar Formation have helped to begin constructing a more complete picture of the paleoenvironmental conditions of the Northern Awash during the Pliocene. This work is an attempt to begin to answer the questions about salinity/alkalinity of Hadar Paleolake as well as its sulfur content. The two sites, NAW and NAO, are about 3 kilometers apart and presumably part of the same paleolake basin. The data has shown that this area was much more humid during the Pliocene than it is today and that most of the minerals in the paleolake basin are detrital, save for calcite, Mg-calcite, gypsum, pyrite, and a few zeolites. 060 analyses of the clays in the cores show that the lake was a freshwater lake three million years ago, up until its eventual evaporation. Interestingly, the lack of trioctahedral clays is an indication that the lake water did not become highly saline and alkaline during its evaporation. An interesting contrast between the two cores shows that NAO contains gypsum, but so far, no pyrite. NAW, on the other hand, contains both pyrite and gypsum. The pyrite in NAW is mostly at the bottom of the core, whereas, the gypsum is intermittent throughout the core and much more sparse toward the bottom. This line of evidence suggests that the two sites within the lake may have experienced different redox conditions. It may be that the NAO core was sampled in a shallower part of the lake whereas the NAW core sampled a deeper section.

Prospects for seasonal forecasting of summer drought and low river flow anomalies in England and Wales

NASA Astrophysics Data System (ADS)

Wedgbrow, C. S.; Wilby, R. L.; Fox, H. R.; O'Hare, G.

2002-02-01

Future climate change scenarios suggest enhanced temporal and spatial gradients in water resources across the UK. Provision of seasonal forecast statistics for surface climate variables could alleviate some negative effects of climate change on water resource infrastructure. This paper presents a preliminary investigation of spatial and temporal relationships between large-scale North Atlantic climatic indices, drought severity and river flow anomalies in England and Wales. Potentially useful predictive relationships are explored between winter indices of the Polar-Eurasian (POL) teleconnection pattern, the North Atlantic oscillation (NAO), North Atlantic sea surface temperature anomalies (SSTAs), and the summer Palmer drought severity index (PDSI) and reconstructed river flows in England and Wales. Correlation analyses, coherence testing and an index of forecast potential, demonstrate that preceding winter values of the POL index, SSTA (and to a lesser extent the NAO), provide indications of summer and early autumn drought severity and river flow anomalies in parts of northwest, southwest and southeast England. Correlation analyses demonstrate that positive winter anomalies of T1, POL index and NAO index are associated with negative PDSI (i.e. drought) across eastern parts of the British Isles in summer (r < 0.51). Coherence tests show that a positive winter SSTA (1871-1995) and POL index (1950-95) have preceded below-average summer river flows in the northwest and southwest of England and Wales in 70 to 100% of summers. The same rivers have also experienced below-average flows during autumn following negative winter phases of the NAO index in 64 to 93% of summers (1865-1995). Possible explanations for the predictor-predictand relationships are considered, including the memory of groundwater, and ocean-atmosphere coupling, and regional manifestations of synoptic rainfall processes. However, further research is necessary to increase the number of years and

Millennial surface water dynamics in the Ria de Vigo during the last 3,000 years as revealed by coccolithophores and biomarkers

NASA Astrophysics Data System (ADS)

Alvarez, M. C.; Flores, J. A.; Sierro, F. J.; Diz, P.; Frances, G.; Pelejero, C.; Grimalt, J.

2003-04-01

A combined study of coccolithophore assemblages and biomarkers in gravity core VIR-18 (380 cm long) located in the Ria de Vigo (42°14.07 N, 8°47.37W) at a water depth of 45 m situated in the Ria de Vigo (SW Spain) has allowed us to reconstruct the paleoenvironmental conditions for the last 3000 years. The quantitative distribution of coccolithophore species points to three different intervals along the core, dated by AMS radiocarbon measurements. A first interval (I; ca. 975 BC-252 AD), characterized by high abundances of Calcidiscus leptoporus and Gephyrocapsa muellerae, features moderate temperatures, suggesting a transition from a warmer to a cooler period. A second interval (II; ca. 252-1368 AD), characterized by the dominance of Coccolithus pelagicus, Helicosphaera carteri and Syracosphaera spp., and a high concentration of hexacosanol linked to terrestrial input, is interpreted as having been a humid period with prevailing runoff. The third interval (III; ca. 1368 AD-1950) is characterized by a high abundance of Gephyrocapsa oceanica, high values of alkenones and low values of hexacosanol, and is interpreted as a period of dominance of oceanic conditions within the Ria. Taking into account the ocean-atmospheric system existing in the region studied, we propose an alternance in the North Atlantic Oscillation (NAO) at millennial time scale. A developed upwelling and a good Ria-ocean connection in the warmer Interval I, suggest a NAO+ phase influenced by a Hypsithermal period. The occurrence of the humid and relatively warm Interval II is consistent with a negative phase in the NAO, as well as a relative restriction in ocean-Ria exchange. Interval III, which was dryer and more productive, suggests the dominance of a positive phase in the NAO, with a more intense oceanic connection and more energized upwelling.

Climatic and Societal Causes for Abrupt Environmental Change in the Mediterranean During the Common Era

NASA Astrophysics Data System (ADS)

Mensing, S. A.; Tunno, I.; Sagnotti, L.; Florindo, F.; Noble, P. J.; Archer, C.; Zimmerman, S. R. H.; Pavón-Carrasco, F. J.; Cifnani, G.; Passigli, S.; Piovesan, G.

2015-12-01

We compare climatic and societal causes for abrupt environmental change for the last 2000 years in the Rieti Basin, central Italy using high-resolution sedimentary paleoenvironmental proxies, historical documents, and annually resolved independent climate reconstructions of temperature and precipitation. Pollen zones, identified from temporally constrained cluster analysis, coincide with historic periods developed from well-established ceramic sequences corresponding to the Roman Imperial through Late Antique (1 to 600 CE) Early Medieval (600 to 875 CE), Medieval through Late Medieval (875 to 1400 CE), Renaissance and Modern (1400 to 1725 CE), and Contemporary periods (1725 CE to present). Non-metric dimensional scaling (NMDS) ordination showed that each temporal period occupied a unique ecologic space suggesting that a new landscape was created during each successive historic period. During Roman time, between 1 and 500 CE, a modest decline in forest coincides with a positive phase of the North Atlantic Oscillation (NAO) and drier climate; however mesophyllous forest is preserved. Steep decline in forest cover between 850 and 950 CE coincides with positive temperature anomalies in Europe and a positive NAO. Although this would seem to suggest climate as a cause, temperature and precipitation changes are modest and the magnitude and rapidity of the vegetation change suggests climate played a small role. Archaeological evidence from across Europe identifies socioeconomic factors that produced forest clearing. In contrast, cooler temperatures and a negative NAO (increased ppt) appears to have been a catalyst for land abandonment and forest recovery in the 13th to 14th centuries. The NAO produces opposite effects on societies in the eastern and western Mediterranean with the negative phase in 1400 CE leading to cool wet climate and land abandonment in central Italy but an abrupt shift to drier conditions and change from sedentary village life to nomadism in Syria.

The coolest DA white dwarfs detected at soft X-ray wavelengths

NASA Technical Reports Server (NTRS)

Kidder, K. M.; Holberg, J. B.; Barstow, M. A.; Tweedy, R. W.; Wesemael, F.

1992-01-01

New soft X-ray/EUV photometric observations of the DA white dwarfs KPD 0631 + 1043 = WD 0631 + 107 and PG 1113 + 413 = WD 1113 + 413 are analyzed. Previously reported soft X-ray detections of three other DAs and the failure to detect a fourth DA in deep Exosat observations are investigated. New ground-based spectra are presented for all of the objects, with IUE Ly-alpha spectra for some. These data are used to constrain the effective temperatures and surface gravities. The improved estimates of these parameters are employed to refer a photospheric He abundance for the hotter objects and to elucidate an effective observational low-temperature threshold for the detection of pure hydrogen DA white dwarfs at soft X-ray wavelengths.

Complete daVinci versus laparoscopic pyeloplasty: cost analysis.

PubMed

Bhayani, Sam B; Link, Richard E; Varkarakis, John M; Kavoussi, Louis R

2005-04-01

Computer-assisted pyeloplasty with the daVinci system is an emerging technique to treat ureteropelvic junction (UPJ) obstruction. A relative cost analysis was performed assessing this technology in comparison with purely laparoscopic pyeloplasty. Eight patients underwent computer-assisted (daVinci) dismembered pyeloplasty (CP) via a transperitoneal four-port approach. They were compared with 13 patients who underwent purely laparoscopic pyeloplasty (LP). All patients had a primary UPJ obstruction and were matched for age, sex, and body mass index. The cost of equipment and capital depreciation for both procedures, as well as assessment of room set-up time, takedown time, and personnel were analyzed. Surgeons and nursing staff for both groups were experienced in both laparoscopy and daVinci procedures. One- and two-way financial analysis was performed to assess relative costs. The mean set-up and takedown time was 71 minutes for CP and 49 minutes for LP. The mean length of stay was 2.3 days for CP and 2.5 days for LP. The mean operating room (OR) times for CP and LP were 176 and 210 minutes, respectively. There were no complications in either group. One-way cost analysis with an economic model showed that LP is more cost effective than CP at our hospital if LP OR time is <338 minutes. With adjustment to a volume of 500 daVinci cases/year, CP is still not as cost effective as LP. Two-way sensitivity analysis shows that in-room time must still be <130 minutes and yearly cases must be >500 to obtain cost equivalence for CP. Perioperative parameters for CP are encouraging. However, the costs are a clear disadvantage. In our hospital, it is more cost effective to teach and perform LP than to perform CP.

dK/da effects on the SCC growth rates of nickel base alloys in high-temperature water

NASA Astrophysics Data System (ADS)

Chen, Kai; Wang, Jiamei; Du, Donghai; Andresen, Peter L.; Zhang, Lefu

2018-05-01

The effect of dK/da on crack growth behavior of nickel base alloys has been studied by conducting stress corrosion cracking tests under positive and negative dK/da loading conditions on Alloys 690, 600 and X-750 in high temperature water. Results indicate that positive dK/da accelerates the SCC growth rates, and the accelerating effect increases with dK/da and the initial CGR. The FRI model was found to underestimate the dK/da effect by ∼100X, especially for strain hardening materials, and this underscores the need for improved insight and models for crack tip strain rate. The effect of crack tip strain rate and dK/dt in particular can explain the dK/da accelerating effect.

[Trattamento farmacologico del disturbo da uso di alcol. Evidenze scientifiche].

PubMed

Attilia, Fabio; Perciballi, Roberta; Rotondo, Claudia; Capriglione, Ida; Iannuzzi, Silvia; Attilia, Maria Luisa; Vitali, Mario; Alessandrini, Giovanni; Scamporrino, Maria Concetta Marcella; Fiore, Marco; Ceccanti, Mauro

2018-01-01

RIASSUNTO. La terapia farmacologica nei pazienti con disturbo da uso di alcol riveste un ruolo centrale nel progetto terapeutico, altamente contestualizzato in un approccio multidisciplinare. Sebbene i trattamenti non farmacologici per la dipendenza da alcol risultino ben strutturati e in continua evoluzione, dal punto di vista medico le possibilità di intervento sono realmente ristrette, con poche molecole a disposizione approvate per il disturbo da uso di alcol: nello specifico, l'acamprostato, il naltrexone e, più recentemente, il nalmefene tra gli anticraving; il disulfiram tra gli avversivanti. Nuovi approcci sperimentali stanno cercando di ampliare tale gamma attraverso l'utilizzo di farmaci off-label. Evidenze scientifiche devono supportare l'indicazione terapeutica, quest'ultima deve dimostrarsi "cucita" sulle esigenze del paziente e sulle comorbilità presenti tenendo conto del profilo bio-psico-sociale individuale. Fondamentale risulta il follow-up per valutare la ritenzione in trattamento e il monitoraggio degli outcome alcologici.

[First experience in the thyroid and parathyroid surgery using the da Vinci® system].

PubMed

Al Kadah, B; Siemer, S; Schick, B

2014-01-01

Endoscopic surgery for the treatment of thyroid and parathyroid pathologies is gaining increasing attention. The da Vinci® system has been already widely used in different fields of medicine including recently thyroid and parathyroid surgery. Herein we report our first experiences in endoscopic surgery of thyroid and parathyroid pathologies using the da Vinci® system. 8 patients presenting with struma nodosa in 6 cases and parathyroid adenomas in 2 cases have been treated using the da Vinci® system at the ENT department of Homburg/Saar University. The skin incision to introduce the instruments with the da Vinci® system were axilar or at the lateral segment of the clavicle. The neurovascular structures like inferior laryngeal nerve as well as the pathologies were clearly 3-dimensional visualized in all 8 cases. No paralysis of the vocal cord was observed. All patients had in histological examination a benign pathology. The endoscopic surgery of the thyroid and parathyroid gland can be performed using the da Vinci® system and offers an excellent, intraoperative, 3-dimensional visualization of the neurovascular structures. Additionally the da Vinci® system enables skin incisions within considerable distance from the thyroid and parathyroid gland. © Georg Thieme Verlag KG Stuttgart · New York.

Strain-controlled electronic properties and magnetorelaxor behaviors in electron-doped CaMnO3 thin films

NASA Astrophysics Data System (ADS)

Xiang, P.-H.; Yamada, H.; Sawa, A.; Akoh, H.

2009-02-01

We have fabricated epitaxial thin films of electron-doped manganite Ca1-xCexMnO3 (CCMO) with 0≤x≤0.08. The transport properties of CCMO films are very sensitive to substrate-controlled epitaxial strain. For the CCMO(x =0.05) film, the metallic transport characteristic is observed only on a nearly lattice-matched NdAlO3 (NAO) substrate, while tensilely and compressively stressed films are insulating. The CCMO(x =0.06) film on the NAO substrate shows a large magnetoresistance characteristic of a magnetorelaxor. This behavior can be explained in terms of the phase separation and the irreversible growth of the metallic domain in antiferromagnetic insulating matrix.

DA-Raf, a dominant-negative antagonist of the Ras-ERK pathway, is a putative tumor suppressor.

PubMed

Kanno, Emiri; Kawasaki, Osamu; Takahashi, Kazuya; Takano, Kazunori; Endo, Takeshi

2018-01-01

Activating mutations of RAS genes, particularly KRAS, are detected with high frequency in human tumors. Mutated Ras proteins constitutively activate the ERK pathway (Raf-MEK-ERK phosphorylation cascade), leading to cellular transformation and tumorigenesis. DA-Raf1 (DA-Raf) is a splicing variant of A-Raf and contains the Ras-binding domain (RBD) but lacks the kinase domain. Accordingly, DA-Raf antagonizes the Ras-ERK pathway in a dominant-negative fashion and suppresses constitutively activated K-Ras-induced cellular transformation. Thus, we have addressed whether DA-Raf serves as a tumor suppressor of Ras-induced tumorigenesis. DA-Raf(R52Q), which is generated from a single nucleotide polymorphism (SNP) in the RBD, and DA-Raf(R52W), a mutant detected in a lung cancer, neither bound to active K-Ras nor interfered with the activation of the ERK pathway. They were incapable of suppressing activated K-Ras-induced cellular transformation and tumorigenesis in mice, in which K-Ras-transformed cells were transplanted. Furthermore, although DA-Raf was highly expressed in lung alveolar epithelial type 2 (AE2) cells, its expression was silenced in AE2-derived lung adenocarcinoma cell lines with oncogenic KRAS mutations. These results suggest that DA-Raf represents a tumor suppressor protein against Ras-induced tumorigenesis. Copyright © 2017 Elsevier Inc. All rights reserved.

Análise da aplicação e dos resultados do modelo OPM3® para a área da saúde

PubMed Central

Augusto dos Santos, Luis; de Fátima Marin, Heimar

2015-01-01

Esta pesquisa procurou analisar se um modelo de questionário criado por uma comunidade internacional de gerenciamento de projetos e se é aplicavél a organizações voltadas a área de saúde. O modelo OPM3® (Organizational Project Management Maturity Model) foi criado para que organizações de qualquer área ou porte pudessem identificar a presença, ou ausência, de boas práticas de gerenciamento. O objetivo da aplicação desse modelo é avaliar sempre a organização e não o entrevistado. No presente artigo, são apresentados os resultados da aplicação desse modelo em uma organização que possuía produtos e serviços de tecnologia da informação aplicados à área de saúde. Este estudo verificou que o modelo é aplicável de forma rápida e que a organização analisada possuía um número expressivo de boas práticas. PMID:26924862

ATLAS WORLD-cloud and networking in PanDA

NASA Astrophysics Data System (ADS)

Barreiro Megino, F.; De, K.; Di Girolamo, A.; Maeno, T.; Walker, R.; ATLAS Collaboration

2017-10-01

The ATLAS computing model was originally designed as static clouds (usually national or geographical groupings of sites) around the Tier 1 centres, which confined tasks and most of the data traffic. Since those early days, the sites’ network bandwidth has increased at 0(1000) and the difference in functionalities between Tier 1s and Tier 2s has reduced. After years of manual, intermediate solutions, we have now ramped up to full usage of World-cloud, the latest step in the PanDA Workload Management System to increase resource utilization on the ATLAS Grid, for all workflows (MC production, data (re)processing, etc.). We have based the development on two new site concepts. Nuclei sites are the Tier 1s and large Tier 2s, where tasks will be assigned and the output aggregated, and satellites are the sites that will execute the jobs and send the output to their nucleus. PanDA dynamically pairs nuclei and satellite sites for each task based on the input data availability, capability matching, site load and network connectivity. This contribution will introduce the conceptual changes for World-cloud, the development necessary in PanDA, an insight into the network model and the first half-year of operational experience.

Yarkovsky-driven Impact Predictions: Apophis and 1950 DA

NASA Astrophysics Data System (ADS)

Farnocchia, Davide; Chesley, S. R.; Chodas, P.; Milani, A.

2013-05-01

Abstract (2,250 Maximum Characters): Orbit determination for Near-Earth Asteroids presents unique technical challenges due to the imperative of early detection and careful assessment of the risk posed by specific Earth close approaches. The occurrence of an Earth impact can be decisively driven by the Yarkovsky effect, which is the most important nongravitational perturbation as it causes asteroids to undergo a secular variation in semimajor axis resulting in a quadratic effect in anomaly. We discuss the cases of (99942) Apophis and (29075) 1950 DA. The relevance of the Yarkovsky effect for Apophis is due to a scattering close approach in 2029 with minimum geocentric distance ~38000 km. For 1950 DA the influence of the Yarkovsky effect in 2880 is due to the long time interval preceding the impact. We use the available information on the asteroids' physical models as a starting point for a Monte Carlo method that allow us to measure how the Yarkovsky effect affects orbital predictions. For Apophis we map onto the 2029 close approach b-plane and analyze the keyholes corresponding to resonant close approaches. For 1950 DA we use the b-plane corresponding to the possible impact in 2880. We finally compute the impact probability from the mapped probability density function on the considered b-plane.

[Anesthesia experiences on laparoscopic nephrectomy with da Vinci S robotics].

PubMed

Mou, Ling; Lan, Zhixun

2015-09-01

To summarize the clinical anesthesia experiences in 20 patients who underwent laparoscopic nephrectomy with da Vinci S robotics.
 Anesthesia data of 20 patients from Sichuan Provincial People's Hospital, who underwent laparoscopic nephrectomy with da Vinci S robotics from August 2014 to November 2014, were analyzed and summarized. The anesthesia time, operation time, CO(2) pneumoperitoneum time, PaCO(2) and PETCO(2) were recorded.
 All patients were anesthetized and underwent surgery with da Vinci S robotics. The anesthesia time was (220±14) min, the operation time was (187±11) min, and the CO(2) pneumoperitoneum time was (180±13) min. The PaCO(2) and PETCO(2) were significantly elevated at 1.5 h after operation compared with those at the baseline (before pneumoperitoneum) (P<0.05). The pH value was significantly decreased at 2.5 h after operation compared to that at the baseline (P<0.05). The peak airway pressure of inspiration was significantly elevated at 0.5 h after the beginning of pneumoperitoneum compared to that at the baseline (P<0.05).
 The hemodynamics is stable during the laparoscopic nephrectomy with da vinci S robotics. However, the duration of CO(2) pneumoperitoneum is significantly increased compared to that of other surgical procedures, resulting in high airway resistance and acid-base disturbance.

Dioscorea Extract (DA-9801) Modulates Markers of Peripheral Neuropathy in Type 2 Diabetic db/db Mice.

PubMed

Moon, Eunjung; Lee, Sung Ok; Kang, Tong Ho; Kim, Hye Ju; Choi, Sang Zin; Son, Mi-Won; Kim, Sun Yeou

2014-09-01

The purpose of this study was to investigate the therapeutic effects of DA-9801, an optimized extract of Dioscorea species, on diabetic peripheral neuropathy in a type 2 diabetic animal model. In this study, db/db mice were treated with DA-9801 (30 and 100 mg/kg, daily, p.o.) for 12 weeks. DA-9801 reduced the blood glucose levels and increased the withdrawal latencies in hot plate tests. Moreover, it prevented nerve damage based on increased nerve conduction velocity and ultrastructural changes. Decrease of nerve growth factor (NGF) may have a detrimental effect on diabetic neuropathy. We previously reported NGF regulatory properties of the Dioscorea genus. In this study, DA-9801 induced NGF production in rat primary astrocytes. In addition, it increased NGF levels in the sciatic nerve and the plasma of type 2 diabetic animals. DA-9801 also increased neurite outgrowth and mRNA expression of Tieg1/Klf10, an NGF target gene, in PC12 cells. These results demonstrated the attenuation of diabetic peripheral neuropathy by oral treatment with DA-9801 via NGF regulation. DA-9801 is currently being evaluated in a phase II clinical study.

Vectra DA for the objective measurement of disease activity in patients with rheumatoid arthritis.

PubMed

Segurado, O G; Sasso, E H

2014-01-01

Quantitative and regular assessment of disease activity in rheumatoid arthritis (RA) is required to achieve treatment targets such as remission and to optimize clinical outcomes. To assess inflammation accurately, predict joint damage and monitor treatment response, a measure of disease activity in RA should reflect the pathological processes resulting in irreversible joint damage and functional disability. The Vectra DA blood test is an objective measure of disease activity for patients with RA. Vectra DA provides an accurate, reproducible score on a scale of 1 to 100 based on the concentrations of 12 biomarkers that reflect the pathophysiologic diversity of RA. The analytical validity, clinical validity, and clinical utility of Vectra DA have been evaluated for patients with RA in registries and prospective and retrospective clinical studies. As a biomarker-based instrument for assessing disease activity in RA, the Vectra DA test can help monitor therapeutic response to methotrexate and biologic agents and assess clinically challenging situations, such as when clinical measures are confounded by non-inflammatory pain from fibromyalgia. Vectra DA scores correlate with imaging of joint inflammation and are predictive for radiographic progression, with high Vectra DA scores being associated with more frequent and severe progression and low scores being predictive for non-progression. In summary, the Vectra DA score is an objective measure of RA disease activity that quantifies inflammatory status. By predicting risk for joint damage more effectively than conventional clinical and laboratory measures, it has the potential to complement these measures and optimise clinical decision making.

Maize 27 kDa gamma-zein is a potential allergen for early weaned pigs.

PubMed

Krishnan, Hari B; Kerley, Monty S; Allee, Gary L; Jang, Sungchan; Kim, Won-Seok; Fu, Chunjiang J

2010-06-23

Soybean and maize are extensively used in animal feed, primarily in poultry, swine, and cattle diets. Soybean meal can affect pig performance in the first few weeks following weaning and elicit specific antibodies in weaned piglets. Though maize is a major component of pig feed, it is not known if any of the maize proteins can elicit immunological response in young pigs. In this study, we have identified a prominent 27 kDa protein from maize as an immunodominant protein in young pigs. This protein, like some known allergens, exhibited resistance to pepsin digestion in vitro. Several lines of evidence identify the immunodominant 27 kDa protein as a gamma-zein, a maize seed storage protein. First, sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) analysis of different solubility classes of maize seed proteins revealed the presence of an abundant 27 kDa protein in the prolamin (zein) fraction. Antibodies raised against the purified maize 27 kDa gamma-zein also reacted against the same protein recognized by the young pig serum. Additionally, matrix-assisted laser desorption ionization time-of-flight mass spectrometry analysis of the peptides generated by trypsin digestion of the immunodominant 27 kDa protein showed significant homology to the maize 27 kDa gamma-zein. Since eliminating the allergenic protein will have a great impact on the nutritive value of the maize meal and expand its use in the livestock industry, it will be highly desirable to develop maize cultivars completely lacking the 27 kDa allergenic protein.

The da Vinci robotic surgical assisted anterior lumbar interbody fusion: technical development and case report.

PubMed

Beutler, William J; Peppelman, Walter C; DiMarco, Luciano A

2013-02-15

Technique development to use the da Vince Robotic Surgical System for anterior lumbar interbody fusion at L5-S1 is detailed. A case report is also presented. To evaluate and develop the da Vinci robotic assisted laparoscopic anterior lumbar stand-alone interbody fusion procedure. Anterior lumbar interbody fusion is a common procedure associated with potential morbidity related to the surgical approach. The da Vinci robot provides intra-abdominal dissection and visualization advantages compared with the traditional open and laparoscopic approach. The surgical techniques for approach to the anterior lumbar spine using the da Vinci robot were developed and modified progressively beginning with operative models followed by placement of an interbody fusion cage in the living porcine model. Development continued to progress with placement of fusion cage in a human cadaver, completed first in the laboratory setting and then in the operating room. Finally, the first patient with fusion completed using the da Vinci robot-assisted approach is presented. The anterior transperitoneal approach to the lumbar spine is accomplished with enhanced visualization and dissection capability, with maintenance of pneumoperitoneum using the da Vinci robot. Blood loss is minimal. The visualization inside the disc space and surrounding structures was considered better than current open and laparoscopic techniques. The da Vinci robot Surgical System technique continues to develop and is now described for the transperitoneal approach to the anterior lumbar spine. 4.

Importance of climatological downscaling and plant phenology for red deer in heterogeneous landscapes

PubMed Central

Pettorelli, Nathalie; Mysterud, Atle; Yoccoz, Nigel G; Langvatn, Rolf; Stenseth, Nils Chr

2005-01-01

Understanding how climate influences ecosystems represents a challenge in ecology and natural resource management. Although we know that climate affects plant phenology and herbivore performances at any single site, no study has directly coupled the topography–climate interaction (i.e. the climatological downscaling process) with large-scale vegetation dynamics and animal performances. Here we show how climatic variability (measured by the North Atlantic oscillation ‘NAO’) interacts with local topography in determining the vegetative greenness (as measured by the normalized difference vegetation index ‘NDVI’) and the body masses and seasonal movements of red deer (Cervus elaphus) in Norway. Warm springs induced an earlier onset of vegetation, resulting in earlier migration and higher body masses. Increasing values of the winter-NAO corresponded to less snow at low altitude (warmer, more precipitation results in more rain), but more snow at high altitude (colder, more precipitation corresponds to more snow) relative to winters with low winter-NAO. An increasing NAO thus results in a spatially more variable phenology, offering migrating deer an extended period with access to high-quality forage leading to increased body mass. Our results emphasize the importance of incorporating spring as well as the interaction between winter climate and topography when aiming at understanding how plant and animal respond to climate change. PMID:16243701

Long term changes in flooding and heavy rainfall associated with North Atlantic tropical cyclones: Roles of the North Atlantic Oscillation and El Niño-Southern Oscillation

NASA Astrophysics Data System (ADS)

Aryal, Yog N.; Villarini, Gabriele; Zhang, Wei; Vecchi, Gabriel A.

2018-04-01

The aim of this study is to examine the contribution of North Atlantic tropical cyclones (TCs) to flooding and heavy rainfall across the continental United States. Analyses highlight the spatial variability in these hazards, their temporal changes in terms of frequency and magnitude, and their connection to large-scale climate, in particular to the North Atlantic Oscillation (NAO) and El Niño-Southern Oscillation (ENSO). We use long-term stream and rain gage measurements, and our analyses are based on annual maxima (AMs) and peaks-over-threshold (POTs). TCs contribute to ∼20-30% of AMs and POTs over Florida and coastal areas of the eastern United States, and the contribution decreases as we move inland. We do not detect statistically significant trends in the magnitude or frequency of TC floods. Regarding the role of climate, NAO and ENSO do not play a large role in controlling the frequency and magnitude of TC flooding. The connection between heavy rainfall and TCs is comparable to what observed in terms of flooding. Unlike flooding, NAO plays a significant role in TC-related extreme rainfall along the U.S. East Coast, while ENSO is most strongly linked to the TC precipitation in Texas.

Lithium Superoxide Hydrolysis and Relevance to Li–O 2 Batteries

DOE PAGES

Wang, Hsien -Hau; Lee, Yun Jung; Assary, Rajeev S.; ...

2017-04-17

Fundamental understanding of reactions of lithium peroxides and superoxides is essential for the development of Li–O 2 batteries. In this context, an investigation is reported of the hydrolysis of lithium superoxide, which has recently been synthesized in a Li–O 2 battery. Surprisingly, the hydrolysis of solid LiO 2 is significantly different from that of NaO 2 and KO 2. Unlike KO 2 and NaO 2, the hydrolysis of LiO 2 does not produce H 2O 2. Similarly, the reactivity of Li 2O 2 toward water differs from LiO 2, in that Li 2O 2 results in H 2O 2 asmore » a product. The difference in the LiO 2 reactivity with water is due to the more exothermic nature of the formation of LiOH and O 2 compared with the corresponding reactions of NaO 2 and KO 2. Here, we also show that a titration method used in this study, based on reaction of the discharge product with a Ti(IV)OSO 4 solution, provides a useful diagnostic technique to provide information on the composition of a discharge product in a Li–O 2 battery.« less

Interannual differences for sea turtles bycatch in Spanish longliners from Western Mediterranean Sea.

PubMed

Báez, José C; Macías, David; García-Barcelona, Salvador; Real, Raimundo

2014-01-01

Recent studies showed that regional abundance of loggerhead and leatherback turtles could oscillate interannually according to oceanographic and climatic conditions. The Western Mediterranean is an important fishing area for the Spanish drifting longline fleet, which mainly targets swordfish, bluefin tuna, and albacore. Due to the spatial overlapping in fishing activity and turtle distribution, there is an increasing sea turtle conservation concern. The main goal of this study is to analyse the interannual bycatch of loggerhead and leatherback turtles by the Spanish Mediterranean longline fishery and to test the relationship between the total turtle by-catch of this fishery and the North Atlantic Oscillation (NAO). During the 14 years covered in this study, the number of sea turtle bycatches was 3,940 loggerhead turtles and 8 leatherback turtles, 0.499 loggerhead turtles/1000 hooks and 0.001014 leatherback turtles/1000 hooks. In the case of the loggerhead turtle the positive phase of the NAO favours an increase of loggerhead turtles in the Western Mediterranean Sea. However, in the case of leatherback turtle the negative phase of the NAO favours the presence of leatherback turtle. This contraposition could be related to the different ecophysiological response of both species during their migration cycle.

Lithium Superoxide Hydrolysis and Relevance to Li–O 2 Batteries

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wang, Hsien -Hau; Lee, Yun Jung; Assary, Rajeev S.

Fundamental understanding of reactions of lithium peroxides and superoxides is essential for the development of Li–O 2 batteries. In this context, an investigation is reported of the hydrolysis of lithium superoxide, which has recently been synthesized in a Li–O 2 battery. Surprisingly, the hydrolysis of solid LiO 2 is significantly different from that of NaO 2 and KO 2. Unlike KO 2 and NaO 2, the hydrolysis of LiO 2 does not produce H 2O 2. Similarly, the reactivity of Li 2O 2 toward water differs from LiO 2, in that Li 2O 2 results in H 2O 2 asmore » a product. The difference in the LiO 2 reactivity with water is due to the more exothermic nature of the formation of LiOH and O 2 compared with the corresponding reactions of NaO 2 and KO 2. Here, we also show that a titration method used in this study, based on reaction of the discharge product with a Ti(IV)OSO 4 solution, provides a useful diagnostic technique to provide information on the composition of a discharge product in a Li–O 2 battery.« less

Sensitivity of marine protected area network connectivity to atmospheric variability

NASA Astrophysics Data System (ADS)

Fox, Alan D.; Henry, Lea-Anne; Corne, David W.; Roberts, J. Murray

2016-11-01

International efforts are underway to establish well-connected systems of marine protected areas (MPAs) covering at least 10% of the ocean by 2020. But the nature and dynamics of ocean ecosystem connectivity are poorly understood, with unresolved effects of climate variability. We used 40-year runs of a particle tracking model to examine the sensitivity of an MPA network for habitat-forming cold-water corals in the northeast Atlantic to changes in larval dispersal driven by atmospheric cycles and larval behaviour. Trajectories of Lophelia pertusa larvae were strongly correlated to the North Atlantic Oscillation (NAO), the dominant pattern of interannual atmospheric circulation variability over the northeast Atlantic. Variability in trajectories significantly altered network connectivity and source-sink dynamics, with positive phase NAO conditions producing a well-connected but asymmetrical network connected from west to east. Negative phase NAO produced reduced connectivity, but notably some larvae tracked westward-flowing currents towards coral populations on the mid-Atlantic ridge. Graph theoretical metrics demonstrate critical roles played by seamounts and offshore banks in larval supply and maintaining connectivity across the network. Larval longevity and behaviour mediated dispersal and connectivity, with shorter lived and passive larvae associated with reduced connectivity. We conclude that the existing MPA network is vulnerable to atmospheric-driven changes in ocean circulation.

Perception of Better Nasal Patency Correlates with Increased Mucosal Cooling after Surgery for Nasal Obstruction

NASA Astrophysics Data System (ADS)

Garcia, Guilherme; Sullivan, Corbin; Frank-Ito, Dennis; Kimbell, Julia; Rhee, John

2014-11-01

Nasal airway obstruction (NAO) is a common health problem with 340,000 patients undergoing surgery annually in the United States. Traditionally, otolaryngologists have focused on airspace cross-sectional areas and nasal resistance to airflow as objective measures of nasal patency, but neither of these variables correlated consistently with patients' symptoms. Given that the sensation of nasal airflow is also associated with mucosal cooling (i.e., heat loss) during inspiration, we investigated the correlation between the sensation of nasal obstruction and mucosal cooling in 10 patients before and after NAO surgery. Three-dimensional models of the nasal anatomy were created based on pre- and post-surgery computed tomography scans. Computational fluid dynamics (CFD) simulations were conducted to quantify nasal resistance and mucosal cooling. Patient-reported symptoms were measured by a visual analog scale and the Nasal Obstruction Symptom Evaluation (NOSE), a disease-specific quality of life questionnaire. Our results revealed that the subjective sensation of nasal obstruction correlated with both nasal resistance and heat loss, but the strongest correlation was between the NOSE score and the nasal surface area where heat flux exceeds 50 W /m2 . In conclusion, a significant post-operative increase in mucosal cooling correlates well with patients' perception of better nasal patency after NAO surgery.

Interannual Differences for Sea Turtles Bycatch in Spanish Longliners from Western Mediterranean Sea

PubMed Central

Báez, José C.; García-Barcelona, Salvador

2014-01-01

Recent studies showed that regional abundance of loggerhead and leatherback turtles could oscillate interannually according to oceanographic and climatic conditions. The Western Mediterranean is an important fishing area for the Spanish drifting longline fleet, which mainly targets swordfish, bluefin tuna, and albacore. Due to the spatial overlapping in fishing activity and turtle distribution, there is an increasing sea turtle conservation concern. The main goal of this study is to analyse the interannual bycatch of loggerhead and leatherback turtles by the Spanish Mediterranean longline fishery and to test the relationship between the total turtle by-catch of this fishery and the North Atlantic Oscillation (NAO). During the 14 years covered in this study, the number of sea turtle bycatches was 3,940 loggerhead turtles and 8 leatherback turtles, 0.499 loggerhead turtles/1000 hooks and 0.001014 leatherback turtles/1000 hooks. In the case of the loggerhead turtle the positive phase of the NAO favours an increase of loggerhead turtles in the Western Mediterranean Sea. However, in the case of leatherback turtle the negative phase of the NAO favours the presence of leatherback turtle. This contraposition could be related to the different ecophysiological response of both species during their migration cycle. PMID:24764769

Changes in Greenland's peripheral glaciers linked to the North Atlantic Oscillation

NASA Astrophysics Data System (ADS)

Bjørk, A. A.; Aagaard, S.; Lütt, A.; Khan, S. A.; Box, J. E.; Kjeldsen, K. K.; Larsen, N. K.; Korsgaard, N. J.; Cappelen, J.; Colgan, W. T.; Machguth, H.; Andresen, C. S.; Peings, Y.; Kjær, K. H.

2018-01-01

Glaciers and ice caps peripheral to the main Greenland Ice Sheet contribute markedly to sea-level rise1-3. Their changes and variability, however, have been difficult to quantify on multi-decadal timescales due to an absence of long-term data4. Here, using historical aerial surveys, expedition photographs, spy satellite imagery and new remote-sensing products, we map glacier length fluctuations of approximately 350 peripheral glaciers and ice caps in East and West Greenland since 1890. Peripheral glaciers are found to have recently undergone a widespread and significant retreat at rates of 12.2 m per year and 16.6 m per year in East and West Greenland, respectively; these changes are exceeded in severity only by the early twentieth century post-Little-Ice-Age retreat. Regional changes in ice volume, as reflected by glacier length, are further shown to be related to changes in precipitation associated with the North Atlantic Oscillation (NAO), with a distinct east-west asymmetry; positive phases of the NAO increase accumulation, and thereby glacier growth, in the eastern periphery, whereas opposite effects are observed in the western periphery. Thus, with projected trends towards positive NAO in the future5,6, eastern peripheral glaciers may remain relatively stable, while western peripheral glaciers will continue to diminish.

The boreal winter Madden-Julian Oscillation's influence on summertime precipitation in the greater Caribbean

NASA Astrophysics Data System (ADS)

Curtis, Scott; Gamble, Douglas W.

2016-07-01

Precipitation totals in the greater Caribbean are known to be affected by interannual variability. In particular, dry conditions in the spring-summer have been physically linked to the positive phase of North Atlantic Oscillation (NAO) in the literature. In this study, it was found through regression analysis that an active Madden-Julian Oscillation (MJO) in winter geographically focused over the Maritime Continent contributes to a positive NAO in March via the generation of Rossby waves in the Northern Hemisphere. Specifically, a negative Pacific-North American pattern develops in the winter and transitions to an Atlantic pattern in spring. The positive NAO is a transient feature of this evolving wave train, but a center of significant positive 200 hPa geopotential heights is entrenched over the southeast U.S. throughout the February to May time period and is manifested as high pressure at the surface. The southern flank of this system increases the speeds of the trade winds and leads to a cooling of the Caribbean sea surface temperatures and, thus, convection suppression and reduced precipitation. Thus, this study advances our understanding of the climate of the greater Caribbean by using climate teleconnections to relate the MJO to rainfall in the region.

Specific cytoarchitectureal changes in hippocampal subareas in daDREAM mice.

PubMed

Mellström, Britt; Kastanauskaite, Asta; Knafo, Shira; Gonzalez, Paz; Dopazo, Xose M; Ruiz-Nuño, Ana; Jefferys, John G R; Zhuo, Min; Bliss, Tim V P; Naranjo, Jose R; DeFelipe, Javier

2016-02-29

Transcriptional repressor DREAM (downstream regulatory element antagonist modulator) is a Ca(2+)-binding protein that regulates Ca(2+) homeostasis through gene regulation and protein-protein interactions. It has been shown that a dominant active form (daDREAM) is implicated in learning-related synaptic plasticity such as LTP and LTD in the hippocampus. Neuronal spines are reported to play important roles in plasticity and memory. However, the possible role of DREAM in spine plasticity has not been reported. Here we show that potentiating DREAM activity, by overexpressing daDREAM, reduced dendritic basal arborization and spine density in CA1 pyramidal neurons and increased spine density in dendrites in dentate gyrus granule cells. These microanatomical changes are accompanied by significant modifications in the expression of specific genes encoding the cytoskeletal proteins Arc, Formin 1 and Gelsolin in daDREAM hippocampus. Our results strongly suggest that DREAM plays an important role in structural plasticity in the hippocampus.

Estudo de não gaussianidade nas anisotropias da RCF medidas Wmap

NASA Astrophysics Data System (ADS)

Andrade, A. P. A.; Wuensche, C. A.; Ribeiro, A. L. B.

2003-08-01

A investigação do campo de flutuações da Radiação Cósmica de Fundo (RCF) pode oferecer um importante teste para os modelos cosmológicos que descrevem a origem e a evolução das flutuações primordiais. De um lado, apresenta-se o modelo inflacionário que prevê um espectro de flutuações adiabáticas distribuídas segundo uma gaussiana e, de outro, os modelos de defeitos topológicos (dentre outros) que descrevem um mecanismo para a geração de flutuações de isocurvatura que obedecem a uma distribuição não gaussiana. Este trabalho tem como objetivo caracterizar traços do modelo não gaussiano de campo misto (entre flutuações adiabáticas e de isocurvatura) nos mapas do Wilkinson Microwave Anisotropy Probe (WMAP). Simulações das anisotropias da RCF no contexto de mistura indicam traços marcantes na distribuição das flutuações de temperatura, mesmo quando consideradas pequenas contribuições do campo de isocurvatura (da ordem de 0.001). O efeito da mistura entre os campos resulta na transferência de potência de flutuações em escalas angulares intermediárias para flutuações em pequenas escalas angulares. Este efeito pode ser caracterizado pela relação entre as amplitudes dos primeiros picos acústicos no espectro de potência da RCF. Neste trabalho, investigamos a contribuição do campo de isocurvatura, no contexto de mistura, sobre as observações recentes da RCF realizadas pelo WMAP. As previsões do modelo de campo misto, uma vez confrontadas com as observações em pequenas escalas angulares, podem ajudar a revelar a natureza das flutuações primordiais.

Integration of PanDA workload management system with Titan supercomputer at OLCF

NASA Astrophysics Data System (ADS)

De, K.; Klimentov, A.; Oleynik, D.; Panitkin, S.; Petrosyan, A.; Schovancova, J.; Vaniachine, A.; Wenaus, T.

2015-12-01

The PanDA (Production and Distributed Analysis) workload management system (WMS) was developed to meet the scale and complexity of LHC distributed computing for the ATLAS experiment. While PanDA currently distributes jobs to more than 100,000 cores at well over 100 Grid sites, the future LHC data taking runs will require more resources than Grid computing can possibly provide. To alleviate these challenges, ATLAS is engaged in an ambitious program to expand the current computing model to include additional resources such as the opportunistic use of supercomputers. We will describe a project aimed at integration of PanDA WMS with Titan supercomputer at Oak Ridge Leadership Computing Facility (OLCF). The current approach utilizes a modified PanDA pilot framework for job submission to Titan's batch queues and local data management, with light-weight MPI wrappers to run single threaded workloads in parallel on Titan's multicore worker nodes. It also gives PanDA new capability to collect, in real time, information about unused worker nodes on Titan, which allows precise definition of the size and duration of jobs submitted to Titan according to available free resources. This capability significantly reduces PanDA job wait time while improving Titan's utilization efficiency. This implementation was tested with a variety of Monte-Carlo workloads on Titan and is being tested on several other supercomputing platforms. Notice: This manuscript has been authored, by employees of Brookhaven Science Associates, LLC under Contract No. DE-AC02-98CH10886 with the U.S. Department of Energy. The publisher by accepting the manuscript for publication acknowledges that the United States Government retains a non-exclusive, paid-up, irrevocable, world-wide license to publish or reproduce the published form of this manuscript, or allow others to do so, for United States Government purposes.

A Creative Approach to the Common Core Standards: The Da Vinci Curriculum

ERIC Educational Resources Information Center

Chaucer, Harry

2012-01-01

"A Creative Approach to the Common Core Standards: The Da Vinci Curriculum" challenges educators to design programs that boldly embrace the Common Core State Standards by imaginatively drawing from the genius of great men and women such as Leonardo da Vinci. A central figure in the High Renaissance, Leonardo made extraordinary contributions as a…

Potential links between the North Atlantic Oscillation and decreasing precipitation and runoff on Sardinia

NASA Astrophysics Data System (ADS)

Montaldo, Nicola; Sarigu, Alessio

2017-04-01

Recently, climate change and human activities increased the desertification process in the Mediterranean regions, with dramatic consequences for agriculture and water resources. On the Sardinia island (Italy), runoff decreased significantly in the 1975-2010 period with a mean yearly runoff reduction of more than 50% compared to the previous 1922-1974 period. The decrease in runoff severely impacts the management of water resources on the Sardinia island, resulting in water supply restrictions even for domestic consumption. In the 10 Sardinian basins, with a longer database (at least 40 complete years of data, including data from the past 10 years), the trend of yearly runoff computed with the Mann-Kendall test is negative, with the Mann-Kendall τ values ranging from -0.39 to -0.2. The reason for the decrease in runoff is mainly the alarming decrease in the winter precipitation over the past few decades everywhere on the Sardinia island. Indeed, most of the yearly runoff of the Sardinian basins (on average, 70%) is produced by the winter precipitation due to the typical seasonality of the Mediterranean rainfall regime. Surprisingly, the winter precipitation trend is not homogenous; the negative trend is higher on the Sardinian west coast and becomes lower as one crosses the island toward the east coast. At the rain stations on the east coast, the τ Mann-Kendall values of the winter precipitation become almost half of the τ Mann-Kendall values on the west coast, which is exposed to the western European climate dynamics. In this sense, winter precipitation is highly correlated with the North Atlantic Oscillation (NAO), which is a weather phenomenon in the North Atlantic Ocean that controls the direction and strength of westerly winds and storm tracks into Europe. High negative correlations (up to -0.45) between winter NAO and winter precipitation are estimated along the west coast. Meanwhile, the correlations decrease as one crosses the island toward the east

Reconstructing the leading mode of multi-decadal North Atlantic variability over the last two millenia using functional paleoclimate networks

NASA Astrophysics Data System (ADS)

Franke, Jasper G.; Werner, Johannes; Donner, Reik V.

2017-04-01

The increasing availability of high-resolution North Atlantic paleoclimate proxies allows to not only study local climate variations in time, but also temporal changes in spatial variability patterns across the entire region possibly controlled by large-scale coherent variability modes such as the North Atlantic Oscillation (NAO) and Atlantic Multidecadal Oscillation. In this study, we use functional paleoclimate network analysis [1,2] to investigate changes in the statistical similarity patterns among an ensemble of high-resolution terrestrial paleoclimate records from Northern Europe included in the Arctic 2k data base. Specifically, we construct complex networks capturing the mutual statistical similarity of inter-annual temperature variability recorded in tree ring records, ice cores and lake sediments for multidecadal time windows covering the last two millenia. The observed patterns of co-variability are ultimately connected to the North Atlantic atmospheric circulation and most prominently to multidecadal variations of the NAO. Based on the inferred networks, we study the dynamical similarity between regional clusters of archives defined according to present-day inter-annual temperature variations across the study region. This analysis identifies those time-dependent inter-regional linkages that are most informative about the leading-order North Atlantic climate variability according to a recent NAO reconstruction for the last millenium [3]. Based on these linkages, we extend the existing reconstruction to obtain qualitative information on multidecadal to centennial scale North Atlantic climate variability over the last two millenia. In general, we find a tendency towards a dominating positive NAO phase interrupted by pronounced and extended intervals of negative NAO. Relatively rapid transitions between both types of behaviour are present during distinct periods including the Little Ice Age, the Medieval Climate Anomaly and for the Dark Ages Little Ice Age

Spatiotemporal patterns of precipitation extremes in the Poyang Lake basin, China: Changing properties and causes

NASA Astrophysics Data System (ADS)

Xiao, M.

2016-12-01

Under the background of climate change, extensive attentions have been paid on the increased extreme precipitation from the public and government. To analyze the influences of large-scale climate indices on the precipitation extremes, the spatiotemporal patterns of precipitation extremes in the Poyang Lake basin have been investigated using the Bayesian hierarchical method. The seasonal maximum one-day precipitation amount (Rx1day) was used to represent the seasonal precipitation extremes. Results indicated that spring Rx1day was affected by El Niño/Southern Oscillation (ENSO) and North Atlantic Oscillation (NAO), a positive ENSO event in the same year tends to decrease the spring Rx1day in the northern part of Poyang Lake Basin while increase the spring Rx1day in southeastern Poyang Lake Basin, a positive NAO events in the same year tends to increase the spring Rx1day in the southwest and northwest part of Poyang Lake basin while decrease the spring Rx1day in the eastern part of Poyang Lake basin; summer Rx1day was affected by Indian Ocean Dipole (IOD), positive IOD events in the same year tend to increase the summer Rx1day of northern Poyang Lake basin while decrease summer Rx1day of southern Poyang Lake basin; autumn Rx1day was affected by ENSO, positive ENSO events in the same year tend to mainly increase the autumn Rx1day in the west part of Poyang Lake basin; winter Rx1day was mainly affected by the NAO, positive NAO events in the same year tend to mainly increase the winter Rx1day of southern Poyang Lake basin, while positive NAO events in the previous year tend to mainly increase the winter Rx1day in the central and northeast part of Poyang Lake basin. It is considered that the region with the negative vertical velocity is dominated by more precipitation and vice versa. Furthermore, field patterns of 500 hPa vertical velocity anomalies related to each climate index have further corroborated the influences of climate indices on the seasonal Rx1day, and

Low strain, long life creep fatigue of AF2-1DA and INCO 718

NASA Technical Reports Server (NTRS)

Thakker, A. B.; Cowles, B. A.

1983-01-01

Two aircraft turbine disk alloys, GATORIZED AF2-DA and INCO 718 were evaluated for their low strain long life creep-fatigue behavior. Static (tensile and creep rupture) and cyclic properties of both alloys were characterized. The cntrolled strain LCF tests were conducted at 760 C (1400 F) and 649 C (1200 F) for AF2-1DA and INCO 718, respectively. Hold times were varied for tensile, compressive and tensile/compressive strain dwell (relaxation) tests. Stress (creep) hold behavior of AF2-1DA was also evaluated. Generally, INCO 718 exhibited more pronounced reduction in cyclic life due to hold than AF2-1DA. The percent reduction in life for both alloys for strain dwell tests was greater at low strain ranges (longer life regime). Changing hold time from 0 to 0.5, 2.0 and 15.0 min. resulted in corresponding reductions in life. The continuous cycle and cyclic/dwell initiation failure mechanism was predominantly transgranular for AF2-1DA and intergranular for INCO 718.

Phosphorylation of Tat-interactive protein 60 kDa by protein kinase C epsilon is important for its subcellular localisation.

PubMed

Sapountzi, Vasileia; Logan, Ian R; Nelson, Glyn; Cook, Susan; Robson, Craig N

2008-01-01

Tat-interactive protein 60 kDa is a nuclear acetyltransferase that both coactivates and corepresses transcription factors and has a definitive function in the DNA damage response. Here, we provide evidence that Tat-interactive protein 60 kDa is phosphorylated by protein kinase C epsilon. In vitro, protein kinase C epsilon phosphorylates Tat-interactive protein 60 kDa on at least two sites within the acetyltransferase domain. In whole cells, activation of protein kinase C increases the levels of phosphorylated Tat-interactive protein 60 kDa and the interaction of Tat-interactive protein 60 kDa with protein kinase C epsilon. A phosphomimetic mutant Tat-interactive protein 60 kDa has distinct subcellular localisation compared to the wild-type protein in whole cells. Taken together, these findings suggest that the protein kinase C epsilon phosphorylation sites on Tat-interactive protein 60 kDa are important for its subcellular localisation. Regulation of the subcellular localisation of Tat-interactive protein 60 kDa via phosphorylation provides a novel means of controlling Tat-interactive protein 60 kDa function.

[The Arabic influence in the "Colóquios dos simples e drogas da India" of Garcia da Orta].

PubMed

Ricordel, Joëlle

2015-09-01

The "Colóquios dos simples e drogas he cousas medicinais de Índia" (Conversations on the simples, drugs and medicinal substances of India) (1563) of Garcia da Orta is a botanical and pharmacognosy book. The author is a Portuguese physician who studied in the Spanish universities and practiced medicine mainly in India. He studies in short chapters presented in the form of dialogues about sixty simples. Sources to which he refers are indicative of a "classical" training, but also the mark of a curious and open mind to different cultures. The Arabic sources are numerous and mainly concern the identification of substances by abundant synonyms of their names in foreign languages and different medicinal uses that may have been done by the ancient physicians. However, Da Orta is critical with respect to these sources, seeking contradictions and differences of opinion among authors. He confronts them with the oral information collected thanks to a wide network of contacts.

A Value-Engaged Approach for Evaluating the Bunche-Da Vinci Learning Academy

ERIC Educational Resources Information Center

Greene, Jennifer C.

2005-01-01

In 2001, the Bunche Academy was chosen by its district to join in partnership with the Da Vinci Learning Corporation to embark on an ambitious whole-school reform initiative, especially designed by the corporation for low-performing schools. In this chapter, the author describes how, as illustrated in the Bunche-Da Vinci Learning Academy context,…

Comparison of Abbott and Da-an real-time PCR for quantitating serum HBV DNA.

PubMed

Qiu, Ning; Li, Rui; Yu, Jian-Guo; Yang, Wen; Zhang, Wei; An, Yong; Li, Tong; Liu, Xue-En; Zhuang, Hui

2014-09-07

To compare the performance of the Da-an real-time hepatitis B virus (HBV) DNA assay and Abbott RealTime HBV assay. HBV DNA standards as well as a total of 180 clinical serum samples from patients with chronic hepatitis B were measured using the Abbott and Da-an real-time polymerase chain reaction (PCR) assays. Correlation and Bland-Altman plot analysis was used to compare the performance of the Abbott and Da-an assays. The HBV DNA levels were logarithmically transformed for analysis. All statistical analyses were performed using SPSS for Windows version 18.0. The correlation between the two assays was analyzed by Pearson's correlation and linear regression. The Bland-Altman plots were used for the analysis of agreement between the two assays. A P value of < 0.05 was considered statistically significant. The HBV DNA values measured by the Abbott or Da-an assay were significantly correlated with the expected values of HBV DNA standards (r = 0.999, for Abbott; r = 0.987, for Da-an, P < 0.001). A Bland-Altman plot showed good agreement between these two assays in detecting HBV DNA standards. Among the 180 clinical serum samples, 126 were quantifiable by both assays. Fifty-two samples were detectable by the Abbott assay but below the detection limit of the Da-an assay. Moreover, HBV DNA levels measured by the Abbott assay were significantly higher than those of the Da-an assay (6.23 ± 1.76 log IU/mL vs 5.46 ± 1.55 log IU/mL, P < 0.001). A positive correlation was observed between HBV DNA concentrations determined by the two assays in 126 paired samples (r = 0.648, P < 0.001). One hundred and fifteen of 126 (91.3%) specimens tested with both assays were within mean difference ± 1.96 SD of HBV DNA levels. The Da-an assay presented lower sensitivity and a narrower linear range as compared to the Abbott assay, suggesting the need to be improved.

Lessons learned - MO&DA at JPL. [Mission Operations and Data Analysis cost reduction of planetary exploration

NASA Technical Reports Server (NTRS)

Handley, Thomas H., Jr.

1993-01-01

The issues of how to avoid future surprise growth in Mission Operations and Data Analysis (MO&DA) costs and how to minimize total MO&DA costs for planetary missions are discussed within the context of JPL mission operations support. It is argued that there is no simple, single solution: the entire Project life-cycle must be addressed. It is concluded that cost models that can predict both MO&DA cost as well as Ground System development costs are needed. The first year MO&DA budget plotted against the total of ground and flight systems developments is shown. In order to better recognize changes and control costs in general, a modified funding line item breakdown is recommended to distinguish between development costs (prelaunch and postlaunch) and MO&DA costs.

Trichinella spiralis: strong antibody response to a 49 kDa newborn larva antigen in infected rats.

PubMed

Salinas-Tobon, Maria Del Rosario; Navarrete-Leon, Anaid; Mendez-Loredo, Blanca Esther; Esquivel-Aguirre, Dalia; Martínez-Abrajan, Dulce Maria; Hernandez-Sanchez, Javier

2007-02-01

In this work, we analyzed the kinetics of anti-Trichinella spiralis newborn larva (NBL) antibodies (Ab) and the antigenic recognition pattern of NBL proteins and its dose effects. Wistar rats were infected with 0, 700, 2000, 4000 and 8000 muscle larvae (ML) and bled at different time intervals up to day 31 post infection (p.i.). Ab production was higher with 2000 ML dose and decreased with 8000, 4000 and 700 ML. Abs were not detected until day 10, peaked on day 14 for the 2000 ML dose and on day 19 for the other doses and thereafter declined slowly from 19 to 31 days p.i. In contrast, Abs to ML increased from day 10, peaked on day 19 and remained high until the end of the study. Abs bound strongly at least to three NBL components of 188, 205 and 49 kDa. NBL antigen of 188 and 205 kDa were recognized 10-26 days p.i. and that of 49 kDa from day 10 to day 31 p.i. A weak recognition towards antigens of 52, 54, 62 and 83 kDa was also observed during the infection. An early recognition of 31, 43, 45, 55, 68 and 85 kDa ML antigens was observed whereas the response to those of 43, 45, 48, 60, 64 and 97 kDa (described previously as TSL-1 antigens) occurred late in the infection. A follow-up of antigen recognition up to day 61 with the optimal immunization dose (2000 ML) evidenced a decline of Ab production to the 49 kDa NBL antigen 42 days p.i., which suggested antigenic differences with the previously reported 43 kDa ML antigen strongly recognized late in the infection. To analyze the stage-specificity of the 49 kDa NBL antigen, polyclonal antibodies (PoAb) were obtained in rats immunized with 49 kDa NBL antigen. PoAb reacted strongly with the 49 kDa NBL component in NBL total soluble extract but no reactivity was observed with soluble antigen of the other T. spiralis stages. Albeit with less intensity, the 49 kDa component was also recognized by PoAb together with other antigens of 53, 97 and 107 kDa, in NBL excretory-secretory products (NBL-ESP). Thus, our results reveal

Isoform composition and stoichiometry of the approx. 90-kDa heat shock protein associated with glucocorticoid receptors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mendel, D.B.; Orti, E.

1988-05-15

The authors observed that the approx. 90-kDa non-steroid-binding component of nonactivated glucocorticoid receptors purified from WEHI-7 mouse thymoma cells (which has been identified as the approx. 90-kDa heat shock protein) consistently migrates as a doublet during polyacrylamide gel electrophoresis under denaturing and reducing conditions. It has recently been reported that murine Meth A cells contain a tumor-specific transplantation antigen (TSTA) which is related or identical to the approx. 90-kDa heat shock protein. The observation that TSTA and the approx. 90-kDa heat shock protein isolated from these cells exists as two isoforms of similar molecular mass and charge has suggested thatmore » the doublet observed is also due to the existence of two isoforms. They have therefore conducted this study to determine whether TSTA and the approx. 90-kDa component of glucocorticoid receptors are indeed related, to establish whether the receptor preferentially binds one isoform of the approx. 90-kDa heat shock protein, and to investigate the stoichiometry of the nonactivated receptor complex. They used the BuGr1 and AC88 monoclonal antibodies to purify, respectively, receptor-associated and free approx. 90-kDa heat shock protein from WEHI-7 cells grown for 48 h with (/sup 35/S)methionine to metabolically label proteins to steady state. The long-term metabolic labeling approach has also enabled them to directly determine that the purified non-activated glucocorticoid receptor contains a single steroid-binding protein and two approx. 90-kDa non-steroid-binding subunits. The consistency with which a approx. 1:2 stoichiometric ratio of steroid binding to approx. 90-kDa protein is observed supports the view that the approx. 90-kDa heat shock protein is a true component of nonactivated glucocorticoid-receptor complexes.« less

40 CFR 60.48Da - Compliance provisions.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 60.48Da Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED... extensions shall be granted by the relevant air division or office director of the appropriate Regional... Protection Agency (U.S. EPA); Office of Air Quality Planning and Standards; Sector Policies and Programs...

40 CFR 60.48Da - Compliance provisions.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 60.48Da Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED... extensions shall be granted by the relevant air division or office director of the appropriate Regional... Protection Agency (U.S. EPA); Office of Air Quality Planning and Standards; Sector Policies and Programs...

Da-KGM based GO-reinforced FMBO-loaded aerogels for efficient arsenic removal in aqueous solution.

PubMed

Ye, Shuxin; Jin, Weiping; Huang, Qing; Hu, Ying; Li, Yan; Li, Jing; Li, Bin

2017-01-01

Composites based on deacetylated konjac glucomannan (Da-KGM) and graphene oxide (GO) aerogels with iron and manganese oxides (FMBO) for effective removal of arsenic from contaminated water. Da-KGM, which was used as supporting composite matrix here, were firstly treated with GO and loaded FMBO. The obtained Da-KGM/GO/FMBO composite aerogels were characterized by compression test, thermo gravimetric analysis (TGA), X-ray diffraction (XRD), fourier transform infrared spectroscopy (FTIR) and scanning electron microscope (SEM). The characteristic results showed that addition of GO exhibited enhanced mechanical properties towards Da-KGM aerogels. What's more, results of FTIR indicated the strong intermolecular hydrogen bond interaction between KGM and GO. Batch adsorption tests were used to evaluate arsenic removal capacity. Da-KGM/GO loaded FMBO composite aerogels exhibited high adsorption ability for arsenite [As(III)] and arsenate [As(V)]. The adsorption results showed that the arsenic for both arsenite [As(III)] and arsenate [As(V)] removal process followed a pseudo-second-order rate equation and Langmuir monolayer adsorption. The maximum As(III) and As(V) uptake capacity of Da-KGM/GO(10%)/FMBO composite aerogels reached 30.21mgg -1 and 12.08mgg -1 respectively according to Langmuir isotherm at pH 7 and 323K. Copyright © 2016 Elsevier B.V. All rights reserved.

Spin-Transfer-Torque Nano-Oscillators: Fabrication, Characterization and Dynamics

NASA Astrophysics Data System (ADS)

Costa, Jose Diogo Teixeira Barbosa

Este trabalho aborda algumas propriedades magneticas e estruturais de nanoparticulas de oxidos e oxidos-hidroxidos de ferro crescidos em matrizes hibridas orgânicas-inorgânicas. As matrizes hibridas, denominadas di-ureasils e obtidas pelo processo sol-gel, sao compostas por uma rede siliciosa ligada covalentemente por pontes ureia a cadeias orgânicas de diferente peso molecular. A estrutura local dos di-ureasils nao dopados esta modelada como grupos de dominios siliciosos com dimensoes nanometricas, estruturalmente correlacionados no seio de uma matriz rica em polimero. Neste trabalho mostra-se que os di-ureasils permitem o crescimento controlado de oxidos e oxidos-hidroxidos de ferro, incluindo a magnetite, maguemite, oxihidroxinitrato de ferro e ferrihidrite. O crescimento das nanoparticulas de ferrihidrite da-se em condicoes acidas a superficie dos dominios siliciosos, junto aos grupos carbonilo, que funcionam como pontos de nucleacao. Desse modo da-se uma nucleacao heterogenea, onde o tamanho das nanoparticulas depende da concentracao de ferro (entre 1 e 6% em massa), sendo a concentracao de particulas constante. As propriedades magneticas das nanoparticulas de ferrihidrite revelam a existencia de interaccoes antiferromagneticas e de momentos descompensados. A contribuicao destas duas componentes nas curvas de magnetizacao em funcao do campo magnetico pode ser separada usando um metodo aqui proposto, o que permite um adequado estudo da evolucao do momento magnetico com a temperatura. O estudo das propriedades magneticas dinâmicas das particulas de ferrihidrite, atraves de susceptibilidade ac, medidas de relaxacao e medidas de efeito Mossbauer, permitiu estudar a evolucao das interaccoes dipolares em funcao da concentracao de ferro, bem como determinar a distribuicao de barreiras de energia de anisotropia no caso em que essas interaccoes sao desprezaveis. E apresentado um novo metodo para comparacao desta distribuicao com a distribuicao de tamanhos, que

Structural and Magnetic Studies on Iron Oxide Nanoparticles in Hybrid Matrices =

NASA Astrophysics Data System (ADS)

Silva, Nuno Joao de Oliveira

Este trabalho aborda algumas propriedades magneticas e estruturais de nanoparticulas de oxidos e oxidos-hidroxidos de ferro crescidos em matrizes hibridas orgânicas-inorgânicas. As matrizes hibridas, denominadas di-ureasils e obtidas pelo processo sol-gel, sao compostas por uma rede siliciosa ligada covalentemente por pontes ureia a cadeias orgânicas de diferente peso molecular. A estrutura local dos di-ureasils nao dopados esta modelada como grupos de dominios siliciosos com dimensoes nanometricas, estruturalmente correlacionados no seio de uma matriz rica em polimero. Neste trabalho mostra-se que os di-ureasils permitem o crescimento controlado de oxidos e oxidos-hidroxidos de ferro, incluindo a magnetite, maguemite, oxihidroxinitrato de ferro e ferrihidrite. O crescimento das nanoparticulas de ferrihidrite da-se em condicoes acidas a superficie dos dominios siliciosos, junto aos grupos carbonilo, que funcionam como pontos de nucleacao. Desse modo da-se uma nucleacao heterogenea, onde o tamanho das nanoparticulas depende da concentracao de ferro (entre 1 e 6% em massa), sendo a concentracao de particulas constante. As propriedades magneticas das nanoparticulas de ferrihidrite revelam a existencia de interaccoes antiferromagneticas e de momentos descompensados. A contribuicao destas duas componentes nas curvas de magnetizacao em funcao do campo magnetico pode ser separada usando um metodo aqui proposto, o que permite um adequado estudo da evolucao do momento magnetico com a temperatura. O estudo das propriedades magneticas dinâmicas das particulas de ferrihidrite, atraves de susceptibilidade ac, medidas de relaxacao e medidas de efeito Mossbauer, permitiu estudar a evolucao das interaccoes dipolares em funcao da concentracao de ferro, bem como determinar a distribuicao de barreiras de energia de anisotropia no caso em que essas interaccoes sao desprezaveis. E apresentado um novo metodo para comparacao desta distribuicao com a distribuicao de tamanhos, que

Synergistic effects of melatonin and deprenyl against MPTP-induced mitochondrial damage and DA depletion.

PubMed

Khaldy, Hoda; Escames, Germaine; León, Josefa; Bikjdaouene, Leila; Acuña-Castroviejo, Darío

2003-01-01

Previous studies showed a synergistic effect of melatonin and deprenyl against dopamine (DA) autoxidation in vitro. Since oxidative stress is implicated in Parkinson's disease (PD), we explored the effects of melatonin plus deprenyl administration in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced PD in C57/Bl6 mice. Melatonin, but not deprenyl prevents the inhibition of mitochondrial complex I and the oxidative damage in nigrostriatal neurons induced by MPTP. With the dose used deprenyl recovers 50% DA levels and tyrosine hydroxylase activity depressed by the neurotoxin, normalizing locomotor activity of mice. Melatonin, which was unable to counteract MPTP-induced DA depletion and inhibition of tyrosine hydroxylase activity, potentiates the effect of deprenyl on catecholamine turnover and mice ambulatory activity. These results suggest a dissociation of complex I inhibition from DA depletion in this model of Parkinson's disease. The data also support that a combination of melatonin, which improves mitochondrial electron transport chain and reduces oxidative damage, and deprenyl, which promotes the specific function of the rescued neurons, i.e. DA turnover, may be a promising strategy for the treatment of PD.

The Effect of DA-6034 on Intestinal Permeability in an Indomethacin-Induced Small Intestinal Injury Model.

PubMed

Kwak, Dong Shin; Lee, Oh Young; Lee, Kang Nyeong; Jun, Dae Won; Lee, Hang Lak; Yoon, Byung Chul; Choi, Ho Soon

2016-05-23

DA-6034 has anti-inflammatory activities and exhibits cytoprotective effects in acute gastric injury models. However, explanations for the protective effects of DA-6034 on intestinal permeability are limited. This study sought to investigate the effect of DA-6034 on intestinal permeability in an indomethacin-induced small intestinal injury model and its protective effect against small intestinal injury. Rats in the treatment group received DA-6034 from days 0 to 2 and indomethacin from days 1 to 2. Rats in the control group received indomethacin from days 1 to 2. On the fourth day, the small intestines were examined to compare the severity of inflammation. Intestinal permeability was evaluated by using fluorescein isothiocyanate-labeled dextran. Western blotting was performed to confirm the association between DA-6034 and the extracellular signal-regulated kinase (ERK) pathway. The inflammation scores in the treatment group were lower than those in the control group, but the difference was statistically insignificant. Hemorrhagic lesions in the treatment group were broader than those in the control group, but the difference was statistically insignificant. Intestinal permeability was lower in the treatment group than in the control group. DA-6034 enhanced extracellular signal-regulated kinase expression, and intestinal permeability was negatively correlated with ERK expression. DA-6034 may decrease intestinal permeability in an indomethacin-induced intestinal injury model via the ERK pathway.

Usefulness of 8 kDa protein of Fasciola hepatica in diagnosis of fascioliasis

PubMed Central

Kim, Kwangsig; Yang, Hyun Jong

2003-01-01

This study was designed to detect and evaluate an antigenicity of low molecular weight proteins of Fasciola hepatica in fascioliasis. Low molecular weight protein of F. hepatica was purified by ammonium sulfate precipitation and Sephacryl S-100 HR gel filtration. The protein obtained was estimated to be 8 kDa on 7.5-15% gradient sodium dodecyl sulfate gel electrophoresis. Immunoblotting studies showed that the 8 kDa protein reacted with human fascioliasis sera, but not other trematodiasis sera. This result suggests that the 8 kDa protein of F. hepatica is one of diagnostic antigens in human fascioliasis without cross-reaction with other human trematodiasis. PMID:12815325

Trisodium citrate, Na 3 (C 6 H 5 O 7 )

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rammohan, Alagappa; Kaduk, James A.

2016-05-10

The crystal structure of anhydrous trisodium citrate, Na 3(C 6H 5O 7), has been solved and refined using synchrotron X-ray powder diffraction data, and optimized using density functional theory (DFT). There are two independent five-coordinate Na +and one six-coordinate Na +cations in the asymmetric unit. The [NaO 5] and [NaO 6] polyhedra share edges and corners to form a three-dimensional framework. There are channels parallel to theaandbaxes in which the remainder of the citrate anions reside. The only hydrogen bonds are an intramolecular one between the hydroxy group and one of the terminal carboxylate O atoms and an intermolecular onemore » between a methylene group and the hydroxyl O atom.« less

New Insights into the Instability of Discharge Products in Na–O 2 Batteries

DOE Office of Scientific and Technical Information (OSTI.GOV)

Landa-Medrano, Imanol; Pinedo, Ricardo; Bi, Xuanxuan

2016-08-10

Sodium–oxygen batteries currently stimulate extensive research due to their high theoretical energy density and improved operational stability when compared to lithium–oxygen batteries. Cell stability, however, needs to be demonstrated also under resting conditions before future implementation of these batteries. In this work we analyze the effect of resting periods on the stability of the sodium superoxide (NaO 2) discharge product. The instability of NaO 2 in the cell environment is demonstrated leading to the evolution of oxygen during the resting period and the decrease of the cell efficiency. In addition, migration of the superoxide anion (O2–) in the electrolyte ismore » observed and demonstrated to be an important factor affecting Coulombic efficiency.« less

Influence of North Atlantic modes on European climate extremes

NASA Astrophysics Data System (ADS)

Proemmel, K.; Cubasch, U.

2017-12-01

It is well known that the North Atlantic strongly influences European climate. Only few studies exist that focus on its impact on climate extremes. We are interested in these extremes and the processes and mechanisms behind it. For the analysis of the North Atlantic Oscillation (NAO) we use simulations performed with the Max Planck Institute for Meteorology Earth System Model (MPI-ESM). The NAO has a strong impact especially on European winter and the changes in minimum temperature are even larger than in maximum temperature. The impact of the Atlantic Multi-decadal Variability (AMV) on climate extremes is analyzed in ECHAM6 simulations forced with AMV warm and AMV cold sea surface temperature patterns. We analyze different extreme indices and try to understand the processes.

Effect of DA-9701 on the Normal Motility and Clonidine-induced Hypomotility of the Gastric Antrum in Rats.

PubMed

Kang, Je Wook; Han, Dae Kyeong; Kim, Ock Nyun; Lee, Kwang Jae

2016-04-30

DA-9701 is a novel prokinetic agent. In the present study, we investigated the effect of DA-9701 on the motility of the gastric antrum in the normal and clonidine-induced hypomotility in an in vivo animal model. A strain gauge force transducer was sutured on the gastric antrum to measure the contractile activity in rats. A total of 28 rats were subclassified into the 4 groups: (1) the placebo group, (2) the DA-9701 group, (3) the placebo group in the clonidine-pretreated rats, and (4) the DA-9701 group in the clonidine-pretreated rats. After the basal recording, either placebo (3% [w/v] hydroxypropylmethyl cellulose) or DA-9701 was administered. Contractile signals were measured after the administration and after a meal. In the clonidinepretreated rats, either placebo or DA-9701 was administered. Contractile signals were measured after the administration and after a meal. Oral administration of DA-9701 did not significantly alter the motility index of the gastric antrum in the preprandial and postprandial periods, compared with the placebo group. The administration of clonidine decreased the motility index of the gastric antrum in the preprandial and postprandial periods, compared with the administration of placebo. This reduction of the antral motility by the administration of clonidine was not observed in the clonidine-pretreated DA-9701 group. The percentage of the motility index in the postprandial period was significantly greater in the clonidine-pretreated DA-9701 group, compared with the clonidine-pretreated placebo group. DA-9701 improves the hypomotility of the gastric antrum induced by clonidine, suggesting its gastroprokinetic effect in the pathologic condition.

Effect of DA-9701 on the Normal Motility and Clonidine-induced Hypomotility of the Gastric Antrum in Rats

PubMed Central

Kang, Je Wook; Han, Dae Kyeong; Kim, Ock Nyun; Lee, Kwang Jae

2016-01-01

Background/Aims DA-9701 is a novel prokinetic agent. In the present study, we investigated the effect of DA-9701 on the motility of the gastric antrum in the normal and clonidine-induced hypomotility in an in vivo animal model. Methods A strain gauge force transducer was sutured on the gastric antrum to measure the contractile activity in rats. A total of 28 rats were subclassified into the 4 groups: (1) the placebo group, (2) the DA-9701 group, (3) the placebo group in the clonidine-pretreated rats, and (4) the DA-9701 group in the clonidine-pretreated rats. After the basal recording, either placebo (3% [w/v] hydroxypropylmethyl cellulose) or DA-9701 was administered. Contractile signals were measured after the administration and after a meal. In the clonidine-pretreated rats, either placebo or DA-9701 was administered. Contractile signals were measured after the administration and after a meal. Results Oral administration of DA-9701 did not significantly alter the motility index of the gastric antrum in the preprandial and postprandial periods, compared with the placebo group. The administration of clonidine decreased the motility index of the gastric antrum in the preprandial and postprandial periods, compared with the administration of placebo. This reduction of the antral motility by the administration of clonidine was not observed in the clonidine-pretreated DA-9701 group. The percentage of the motility index in the postprandial period was significantly greater in the clonidine-pretreated DA-9701 group, compared with the clonidine-pretreated placebo group. Conclusions DA-9701 improves the hypomotility of the gastric antrum induced by clonidine, suggesting its gastroprokinetic effect in the pathologic condition. PMID:26755679

Solving da Vinci stereopsis with depth-edge-selective V2 cells

PubMed Central

Assee, Andrew; Qian, Ning

2007-01-01

We propose a new model for da Vinci stereopsis based on a coarse-to-fine disparity-energy computation in V1 and disparity-boundary-selective units in V2. Unlike previous work, our model contains only binocular cells, relies on distributed representations of disparity, and has a simple V1-to-V2 feedforward structure. We demonstrate with random dot stereograms that the V2 stage of our model is able to determine the location and the eye-of-origin of monocularly occluded regions and improve disparity map computation. We also examine a few related issues. First, we argue that since monocular regions are binocularly defined, they cannot generally be detected by monocular cells. Second, we show that our coarse-to-fine V1 model for conventional stereopsis explains double matching in Panum’s limiting case. This provides computational support to the notion that the perceived depth of a monocular bar next to a binocular rectangle may not be da Vinci stereopsis per se (Gillam et al., 2003). Third, we demonstrate that some stimuli previously deemed invalid have simple, valid geometric interpretations. Our work suggests that studies of da Vinci stereopsis should focus on stimuli more general than the bar-and-rectangle type and that disparity-boundary-selective V2 cells may provide a simple physiological mechanism for da Vinci stereopsis. PMID:17698163

Direct voltammetric specific recognition of dopamine using AlIII-DA complexes at the hanging mercury drop electrode.

PubMed

Zhang, Fuping; Zhang, Min; Cheng, Jiongjia; Yang, Li; Ji, Ming; Bi, Shuping

2007-11-01

In this paper, we firstly report the direct voltammetric recognition and determination of dopamine (DA) by using Al(III)-DA complexes at the hanging mercury drop electrode (HMDE). A new sensitive cathodic peak of Al(III)-DA can be detected at -900 mV (vs. SCE) in 0.1 M NH(4)Cl-NH(3).H(2)O-0.1 M KCl buffer solution at pH 8.5. This unique -900 mV cathodic peak arises from the specific interaction between Al(III) and DA on the HMDE, whereas other substances with similar structures, such as L-dopa, epinephrine (EP), norepinephrine (NE), catechols, caffeic acid (CA), trihydric phenols and tiron, do not yield any new peak on the voltammograms in the potential range from -100 to -1200 mV when Al(III) is added. The distinct voltammetric characteristic of the recognition of DA can effectively inhibit the interferences of both ascorbic acid and uric acid in the DA determination by the direct electrochemistry, which is a major difficulty when a solid electrode is used. The proposed method can be anticipated as an effective means for the recognition of DA in the elucidation of the mechanisms of Parkinson's disease (PD) and Alzheimer's disease (AD) in the presence of Al(III).

SAGES TAVAC safety and effectiveness analysis: da Vinci ® Surgical System (Intuitive Surgical, Sunnyvale, CA).

PubMed

Tsuda, Shawn; Oleynikov, Dmitry; Gould, Jon; Azagury, Dan; Sandler, Bryan; Hutter, Matthew; Ross, Sharona; Haas, Eric; Brody, Fred; Satava, Richard

2015-10-01

The da Vinci(®) Surgical System (Intuitive Surgical, Sunnyvale, CA, USA) is a computer-assisted (robotic) surgical system designed to enable and enhance minimally invasive surgery. The Food and Drug Administration (FDA) has cleared computer-assisted surgical systems for use by trained physicians in an operating room environment for laparoscopic surgical procedures in general, cardiac, colorectal, gynecologic, head and neck, thoracic and urologic surgical procedures. There are substantial numbers of peer-reviewed papers regarding the da Vinci(®) Surgical System, and a thoughtful assessment of evidence framed by clinical opinion is warranted. The SAGES da Vinci(®) TAVAC sub-committee performed a literature review of the da Vinci(®) Surgical System regarding gastrointestinal surgery. Conclusions by the sub-committee were vetted by the SAGES TAVAC Committee and SAGES Executive Board. Following revisions, the document was evaluated by the TAVAC Committee and Executive Board again for final approval. Several conclusions were drawn based on expert opinion organized by safety, efficacy, and cost for robotic foregut, bariatric, hepatobiliary/pancreatic, colorectal surgery, and single-incision cholecystectomy. Gastrointestinal surgery with the da Vinci(®) Surgical System is safe and comparable, but not superior to standard laparoscopic approaches. Although clinically acceptable, its use may be costly for select gastrointestinal procedures. Current data are limited to the da Vinci(®) Surgical System; further analyses are needed.

32 CFR 516.14 - Service of process on DA or Secretary of Army.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 32 National Defense 3 2010-07-01 2010-07-01 true Service of process on DA or Secretary of Army. 516.14 Section 516.14 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY AID OF CIVIL AUTHORITIES AND PUBLIC RELATIONS LITIGATION Service of Process § 516.14 Service of process on DA...

The analysis Arabidopsis thaliana overexpressing a 14kDa self-folding protein [abstract

USDA-ARS?s Scientific Manuscript database

A recent study in banana identified a 14kDa protein that has been hypothesized to function in regulating the nucleation and growth of the needle-shaped crystals of calcium oxalate that accumulate within the tissues of this plant. To gain further insight in to the functional role of this 14 kDa prote...

32 CFR 516.14 - Service of process on DA or Secretary of Army.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 32 National Defense 3 2011-07-01 2009-07-01 true Service of process on DA or Secretary of Army. 516.14 Section 516.14 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY AID OF CIVIL AUTHORITIES AND PUBLIC RELATIONS LITIGATION Service of Process § 516.14 Service of process on DA...

[La diagnosi del disturbo da uso di alcol dal punto di vista psicologico].

PubMed

Coriale, Giovanna; Fiorentino, Daniela; Porrari, Raffaella; Battagliese, Gemma; Capriglione, Ida; Cereatti, Federica; Iannuzzi, Silvia; Mauri, Benilde; Galli, Domenica; Fiore, Marco; Attilia, Maria Luisa; Ceccanti, Mauro

2018-01-01

RIASSUNTO. Il disturbo da uso di alcol (DUA) è uno dei disturbi psichiatrici più comuni nella popolazione generale. Il DUA è caratterizzato da un pattern di bere eccessivo, che si mantiene nonostante gli effetti negativi che l'alcol ha sul funzionamento lavorativo, sulla salute, sulle problematiche legali, sull'educazione e sulla vita sociale. Attualmente, il modello bio-psico-sociale è quello che spiega meglio il DUA. Infatti, molte ricerche hanno fornito evidenze su come il DUA sia una patologia multidimensionale. Variabili biologiche, psicologiche e socio-culturali entrano in gioco nell'eziologia, nella natura, nel mantenimento e nel cambiamento nel tempo del disturbo. La fase diagnostica è un momento importante del processo di cura, perché il successo del trattamento dipende in larga misura dall'esattezza e dall'adeguatezza della diagnosi. La diagnosi clinica si basa su una valutazione globale del funzionamento del paziente e utilizza il colloquio e gli strumenti psicometrici come mezzo di raccolta di informazioni. Questo articolo fornirà una panoramica delle dimensioni psicologiche più importanti da valutare e sui migliori strumenti psicometrici da usare per una diagnosi adeguata.

Hidden sketches by Leonardo da Vinci revealed

NASA Astrophysics Data System (ADS)

Dumé, Belle

2009-02-01

Three drawings on the back of Leonardo da Vinci's The Virgin and Child with St Anne (circa 1508) have been discovered by researchers led by Michel Menu from the Centre de Recherche et de Restauration des Musées de France (C2RMF) and the Louvre Museum in Paris.

[Leonardo da Vinci--a dyslectic genius?].

PubMed

Røsstad, Anna

2002-12-10

Leonardo da Vinci's texts consist almost exclusively of scientific notes. Working on a book on Leonardo's art, I studied all Leonardo's published texts carefully for any new information. In some prefaces I came to suspect that Leonardo might have suffered from dyslexia. This article considers the question of whether it is possible to find indications of dyslexia in Leonardo's texts and in the accounts of his life.

Eventos de Desconexao na Cauda de Plasma do Cometa P/Halley

NASA Astrophysics Data System (ADS)

Voelzke, M. R.; Fahr, H. J.

2001-08-01

Observacoes cometárias e de vento solar sao comparadas com o propósito de determinar-se as condicoes do vento solar associadas aos eventos de desconexao (DEs) observados em caudas de plasma cometárias. Os dados cometários sao provenientes do The International Halley Watch Atlas of Large-Scale Phenomena. A análise visual sistemática das imagens do atlas revelou, entre outras estruturas morfológicas, 47 DEs ao longo da cauda de plasma do P/Halley. Estes 47 DEs registrados em 47 imagens distintas permitiram a descoberta de 19 origens de DEs, ou seja, o tempo em que as desconexoes iniciaram foi calculado. Os dados do vento solar sao provenientes de medidas feitas in situ pela sonda espacial IMP-8, as quais foram usadas para elaborar a variacao da velocidade do vento solar, densidade e pressao dinâmica durante o intervalo analisado. O presente trabalho compara as atuais teorias conflitantes, baseadas nos mecanismos de formacao, com o intuito de explicar o fenômeno cíclico dos DEs, ou seja, os efeitos de producao iônica, os efeitos de pressao e os efeitos de reconexao magnética sao analisados. Para cada uma das 19 origens de DEs comparou-se a densidade com a respectiva velocidade do vento solar com o intuito de determinar-se uma possível correlacao entre estas origens e os efeitos de pressao dinâmica. Quando da ocorrência de 6 origens de DEs o IMP-8 nao realizou medidas, nos outros 13 casos 10 origens (77%) mostraram uma anticorrelacao entre velocidade e densidade e apenas 3 (23%) revelaram uma tendência similar entre velocidade e densidade. Portanto, a análise inicial demonstra uma fraca correlacao entre as origens dos DEs e os efeitos de pressao.

The influence of the North Atlantic Ocean variability on the atmosphere in the cold season at seasonal to multidecadal time scales

NASA Astrophysics Data System (ADS)

Frankignoul, C.

2017-12-01

Observational evidence of an atmospheric response to the North Atlantic horseshoe SST anomalies has been accumulating since the late 90's, suggesting that it drives a negative NAO response during late fall/early winter. The North Atlantic horseshoe SST anomaly is in part stochastically driven by the atmosphere, but at low frequency it is correlated with the Atlantic Multidecadal Oscillation (AMO). Correspondingly, an atmospheric response to the AMO has been detected at low frequency in winter, with a positive AMO phase leading a negative NAO-like pattern, consistent with sensitivity studies with atmospheric general circulation models. Both the subpolar and tropical components of the AMO seem to contribute to its influence on the atmosphere. As North Atlantic SST changes reflects internally-generated SST fluctuations as well the response to anthropogenic and other external forcing, the AMO is sensitive to the way the forced SST signal is removed; estimates of the natural variability of the AMO vary by as much as a factor of two between estimation methods, leading to possible biases in its alleged impacts. Since an intensification of the Atlantic meridional overturning circulation (AMOC) leads the AMO and drives a negative NAO in many climate models, albeit with different lead times, the relation between AMO and AMOC will be discussed, as well as possible links with the North Pacific and sea ice variability.

Feasibility of using a humanoid robot to elicit communicational response in children with mild autism

NASA Astrophysics Data System (ADS)

Malik, Norjasween Abdul; Shamsuddin, Syamimi; Yussof, Hanafiah; Azfar Miskam, Mohd; Che Hamid, Aminullah

2013-12-01

Research evidences are accumulating with regards to the potential use of robots for the rehabilitation of children with autism. The purpose of this paper is to elaborate on the results of communicational response in two children with autism during interaction with the humanoid robot NAO. Both autistic subjects in this study have been diagnosed with mild autism. Following the outcome from our first pilot study; the aim of this current experiment is to explore the application of NAO robot to engage with a child and further teach about emotions through a game-centered and song-based approach. The experiment procedure involved interaction between humanoid robot NAO with each child through a series of four different modules. The observation items are based on ten items selected and referenced to GARS-2 (Gilliam Autism Rating Scale-second edition) and also input from clinicians and therapists. The results clearly indicated that both of the children showed optimistic response through the interaction. Negative responses such as feeling scared or shying away from the robot were not detected. Two-way communication between the child and robot in real time significantly gives positive impact in the responses towards the robot. To conclude, it is feasible to include robot-based interaction specifically to elicit communicational response as a part of the rehabilitation intervention of children with autism.

Sea Surface Temperature Records Using Sr/Ca Ratios in a Siderastrea siderea Coral from SE Cuba

NASA Astrophysics Data System (ADS)

Fargher, H. A.; Hughen, K. A.; Ossolinski, J. E.; Bretos, F.; Siciliano, D.; Gonzalez, P.

2015-12-01

Sea surface temperature (SST) variability from Cuba remains relatively unknown compared to the rest of the Caribbean. Cuba sits near an inflection point in the spatial pattern of SST from the North Atlantic Oscillation (NAO), and long SST records from the region could reveal changes in the influence of this climate system through time. A Siderastrea siderea coral from the Jardínes de la Reina in southern Cuba was drilled to obtain a 220 year long archive of environmental change. The genus Siderastrea has not been extensively studied as an SST archive, yet Sr/Ca ratios in the Cuban core show a clear seasonal signal and strong correlation to instrumental SST data (r2 = 0.86 and 0.36 for monthly and interannual (winter season) timescales, respectively). Annual growth rates (linear extension) of the coral are observed to have a minor influence on Sr/Ca variability, but do not show a direct correlation to SST on timescales from annual to multidecadal. Sr/Ca measurements from the Cuban coral are used to reconstruct monthly and seasonal (winter, summer) SST extending back more than two centuries. Wintertime SST in southern Cuba is compared to other coral Sr/Ca records of winter-season SST from locations sensitive to the NAO in order to investigate the stationarity of the NAO SST 'fingerprint' through time.

Interannual abundance changes of gelatinous carnivore zooplankton unveil climate-driven hydrographic variations in the Iberian Peninsula, Portugal.

PubMed

D'Ambrosio, Mariaelena; Molinero, Juan C; Azeiteiro, Ulisses M; Pardal, Miguel A; Primo, Ana L; Nyitrai, Daniel; Marques, Sónia C

2016-09-01

The persistent massive blooms of gelatinous zooplankton recorded during recent decades may be indicative of marine ecosystem changes. In this study, we investigated the potential influence of the North Atlantic climate (NAO) variability on decadal abundance changes of gelatinous carnivore zooplankton in the Mondego estuary, Portugal, over the period 2003-2013. During the 11-year study, the community of gelatinous carnivores encompassed a larger diversity of hydromedusae than siphonophores; the former dominated by Obelia spp., Lizzia blondina, Clythia hemisphaerica, Liriope tetraphylla and Solmaris corona, while the latter dominated by Muggiaea atlantica. Gelatinous carnivore zooplankton displayed marked interannual variability and mounting species richness over the period examined. Their pattern of abundance shifted towards larger abundances ca. 2007 and significant phenological changes. The latter included a shift in the mean annual pattern (from unimodal to bimodal peak, prior and after 2007 respectively) and an earlier timing of the first annual peak concurrent with enhanced temperatures. These changes were concurrent with the climate-driven environmental variability mainly controlled by the NAO, which displayed larger variance after 2007 along with an enhanced upwelling activity. Structural equation modelling allowed depicting cascading effects derived from the NAO influence on regional climate and upwelling variability further shaping water temperature. Such cascading effect percolated the structure and dynamics of the community of gelatinous carnivore zooplankton in the Mondego estuary. Copyright © 2016 Elsevier Ltd. All rights reserved.

High-Energy-Density Metal-Oxygen Batteries: Lithium-Oxygen Batteries vs Sodium-Oxygen Batteries.

PubMed

Song, Kyeongse; Agyeman, Daniel Adjei; Park, Mihui; Yang, Junghoon; Kang, Yong-Mook

2017-12-01

The development of next-generation energy-storage devices with high power, high energy density, and safety is critical for the success of large-scale energy-storage systems (ESSs), such as electric vehicles. Rechargeable sodium-oxygen (Na-O 2 ) batteries offer a new and promising opportunity for low-cost, high-energy-density, and relatively efficient electrochemical systems. Although the specific energy density of the Na-O 2 battery is lower than that of the lithium-oxygen (Li-O 2 ) battery, the abundance and low cost of sodium resources offer major advantages for its practical application in the near future. However, little has so far been reported regarding the cell chemistry, to explain the rate-limiting parameters and the corresponding low round-trip efficiency and cycle degradation. Consequently, an elucidation of the reaction mechanism is needed for both lithium-oxygen and sodium-oxygen cells. An in-depth understanding of the differences and similarities between Li-O 2 and Na-O 2 battery systems, in terms of thermodynamics and a structural viewpoint, will be meaningful to promote the development of advanced metal-oxygen batteries. State-of-the-art battery design principles for high-energy-density lithium-oxygen and sodium-oxygen batteries are thus reviewed in depth here. Major drawbacks, reaction mechanisms, and recent strategies to improve performance are also summarized. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Variability of the Labrador Sea Surface Eddy Kinetic Energy Observed by Altimeter From 1993 to 2012

NASA Astrophysics Data System (ADS)

Zhang, Weiwei; Yan, Xiao-Hai

2018-01-01

A merged along track altimeter data set is used to study the variability of eddy kinetic energy (EKE) in the Labrador Sea from 1993 to 2012. The EKE near the west Greenland current (WGC) has strong interannual variability without long-term trend from 1993 to 2012. The propagation direction of the Irminger Rings (IRs) originating from the WGC can be inferred from the EKE derived from altimeter, and the southward propagation of the IRs varies interannually. The central Labrador Sea EKE increases significantly from 1993 to 2012. The central Labrador Sea temperature difference between the end and the beginning of the winter convections is defined as restratification index to measure the restratification strengths. The relation between the central Labrador Sea EKE and the restratification index shows that the enhanced eddy activity originating from the west of the central Labrador Sea may cool the central Labrador Sea significantly. The interannual variability of the WGC EKE is likely to be driven by the large scale Subpolar Gyre (SPG) circulation variability and the North Atlantic Oscillation (NAO). The NAO also affects the central Labrador Sea EKE through its fingerprint in the local wind stress and surface heat flux. The NAO affects the WGC EKE by changing the SPG circulation strength, which will subsequently affect the WGC EKE through unknown physical processes.

Changes in aridity in response to the global warming hiatus

NASA Astrophysics Data System (ADS)

Guan, Xiaodan; Huang, Jianping; Guo, Ruixia

2017-02-01

The global warming slowdown or warming hiatus, began around the year 2000 and has persisted for nearly 15 years. Most studies have focused on the interpretation of the hiatus in temperature. In this study, changes in a global aridity index (AI) were analyzed by using a newly developed dynamical adjustment method that can successfully identify and separate dynamically induced and radiatively forced aridity changes in the raw data. The AI and Palmer Drought Severity Index produced a wetting zone over the mid-to-high latitudes of the Northern Hemisphere in recent decades. The dynamical adjustment analysis suggested that this wetting zone occurred in response to the global warming hiatus. The dynamically induced AI (DAI) played a major role in the AI changes during the hiatus period, and its relationships with the North Atlantic Oscillation (NAO), Pacific Decadal Oscillation (PDO), and Atlantic Multi-decadal Oscillation (AMO) also indicated that different phases of the NAO, PDO, and AMO contributed to different performances of the DAI over the Northern Hemisphere. Although the aridity wetting over the mid-to-high latitudes may relieve long-term drying in certain regions, the hiatus is temporary, and so is the relief. Accelerated global warming will return when the NAO, PDO, and AMO revert to their opposite phases in the future, and the wetting zone is likely to disappear.

Formation of the 67-kDa laminin receptor by acylation of the precursor.

PubMed

Butò, S; Tagliabue, E; Ardini, E; Magnifico, A; Ghirelli, C; van den Brûle, F; Castronovo, V; Colnaghi, M I; Sobel, M E; Ménard, S

1998-06-01

Even though the involvement of the 67-kDa laminin receptor (67LR) in tumor invasiveness has been clearly demonstrated, its molecular structure remains an open problem, since only a full-length gene encoding a 37-kDa precursor protein (37LRP) has been isolated so far. A pool of recently obtained monoclonal antibodies directed against the recombinant 37LRP molecule was used to investigate the processing that leads to the formation of the 67-kDa molecule. In soluble extracts of A431 human carcinoma cells, these reagents recognize the precursor molecule as well as the mature 67LR and a 120-kDa molecule. The recovery of these proteins was found to be strikingly dependent upon the cell solubilization conditions: the 67LR is soluble in NP-40-lysis buffer whereas the 37LRP is NP-40-insoluble. Inhibition of 67LR formation by cerulenin indicates that acylation is involved in the processing of the receptor. It is likely a palmitoylation process, as indicated by sensitivity of NP-40-soluble extracts to hydroxylamine treatment. Immunoblotting assays performed with a polyclonal serum directed against galectin3 showed that both the 67- and the 120-kDa proteins carry galectin3 epitopes whereas the 37LRP does not. These data suggest that the 67LR is a heterodimer stabilized by strong intramolecular hydrophobic interactions, carried by fatty acids bound to the 37LRP and to a galectin3 cross-reacting molecule.

PanDA: Exascale Federation of Resources for the ATLAS Experiment at the LHC

NASA Astrophysics Data System (ADS)

Barreiro Megino, Fernando; Caballero Bejar, Jose; De, Kaushik; Hover, John; Klimentov, Alexei; Maeno, Tadashi; Nilsson, Paul; Oleynik, Danila; Padolski, Siarhei; Panitkin, Sergey; Petrosyan, Artem; Wenaus, Torre

2016-02-01

After a scheduled maintenance and upgrade period, the world's largest and most powerful machine - the Large Hadron Collider(LHC) - is about to enter its second run at unprecedented energies. In order to exploit the scientific potential of the machine, the experiments at the LHC face computational challenges with enormous data volumes that need to be analysed by thousand of physics users and compared to simulated data. Given diverse funding constraints, the computational resources for the LHC have been deployed in a worldwide mesh of data centres, connected to each other through Grid technologies. The PanDA (Production and Distributed Analysis) system was developed in 2005 for the ATLAS experiment on top of this heterogeneous infrastructure to seamlessly integrate the computational resources and give the users the feeling of a unique system. Since its origins, PanDA has evolved together with upcoming computing paradigms in and outside HEP, such as changes in the networking model, Cloud Computing and HPC. It is currently running steadily up to 200 thousand simultaneous cores (limited by the available resources for ATLAS), up to two million aggregated jobs per day and processes over an exabyte of data per year. The success of PanDA in ATLAS is triggering the widespread adoption and testing by other experiments. In this contribution we will give an overview of the PanDA components and focus on the new features and upcoming challenges that are relevant to the next decade of distributed computing workload management using PanDA.

Local classification: Locally weighted-partial least squares-discriminant analysis (LW-PLS-DA).

PubMed

Bevilacqua, Marta; Marini, Federico

2014-08-01

The possibility of devising a simple, flexible and accurate non-linear classification method, by extending the locally weighted partial least squares (LW-PLS) approach to the cases where the algorithm is used in a discriminant way (partial least squares discriminant analysis, PLS-DA), is presented. In particular, to assess which category an unknown sample belongs to, the proposed algorithm operates by identifying which training objects are most similar to the one to be predicted and building a PLS-DA model using these calibration samples only. Moreover, the influence of the selected training samples on the local model can be further modulated by adopting a not uniform distance-based weighting scheme which allows the farthest calibration objects to have less impact than the closest ones. The performances of the proposed locally weighted-partial least squares-discriminant analysis (LW-PLS-DA) algorithm have been tested on three simulated data sets characterized by a varying degree of non-linearity: in all cases, a classification accuracy higher than 99% on external validation samples was achieved. Moreover, when also applied to a real data set (classification of rice varieties), characterized by a high extent of non-linearity, the proposed method provided an average correct classification rate of about 93% on the test set. By the preliminary results, showed in this paper, the performances of the proposed LW-PLS-DA approach have proved to be comparable and in some cases better than those obtained by other non-linear methods (k nearest neighbors, kernel-PLS-DA and, in the case of rice, counterpropagation neural networks). Copyright © 2014 Elsevier B.V. All rights reserved.

Effects of porcine 25 kDa amelogenin and its proteolytic derivatives on bone sialoprotein expression.

PubMed

Nakayama, Y; Yang, L; Mezawa, M; Araki, S; Li, Z; Wang, Z; Sasaki, Y; Takai, H; Nakao, S; Fukae, M; Ogata, Y

2010-10-01

Amelogenins are hydrophobic proteins that are the major component of developing enamel. Enamel matrix derivative has been used for periodontal regeneration. Bone sialoprotein is an early phenotypic marker of osteoblast differentiation. In this study, we examined the ability of porcine amelogenins to regulate bone sialoprotein transcription. To determine the molecular basis of the transcriptional regulation of the bone sialoprotein gene by amelogenins, we conducted northern hybridization, transient transfection analyses and gel mobility shift assays using the osteoblast-like ROS 17/2.8 cells. Amelogenins (100 ng/mL) up-regulated bone sialoprotein mRNA at 3 h, with maximal mRNA expression occurring at 12 h (25 and 20 kDa) and 6 h (13 and 6 kDa). Amelogenins (100 ng/mL, 12 h) increased luciferase activities in pLUC3 (nucleotides -116 to +60), and 6 kDa amelogenin up-regulated pLUC4 (nucleotides -425 to +60) activity. The tyrosine kinase inhibitor inhibited amelogenin-induced luciferase activities, whereas the protein kinase A inhibitor abolished 25 kDa amelogenin-induced bone sialoprotein transcription. The effects of amelogenins were abrogated by 2-bp mutations in the fibroblast growth factor 2 response element (FRE). Gel-shift assays with radiolabeled FRE, homeodomain-protein binding site (HOX) and transforming growth factor-beta1 activation element (TAE) double-strand oligonucleotides revealed increased binding of nuclear proteins from amelogenin-stimulated ROS 17/2.8 cells at 3 h (25 and 13 kDa) and 6 h (20 and 6 kDa). These results demonstrate that porcine 25 kDa amelogenin and its proteolytic derivatives stimulate bone sialoprotein transcription by targeting FRE, HOX and TAE in the bone sialoprotein gene promoter, and that full-length amelogenin and amelogenin cleavage products are able to regulate bone sialoprotein transcription via different signaling pathways. (c) 2010 John Wiley & Sons A/S.

Complexity of VTA DA neural activities in response to PFC transection in nicotine treated rats.

PubMed

Chen, Ting Y; Zhang, Die; Dragomir, Andrei; Akay, Yasemin M; Akay, Metin

2011-02-27

The dopaminergic (DA) neurons in the ventral tegmental area (VTA) are widely implicated in the addiction and natural reward circuitry of the brain. These neurons project to several areas of the brain, including prefrontal cortex (PFC), nucleus accubens (NAc) and amygdala. The functional coupling between PFC and VTA has been demonstrated, but little is known about how PFC mediates nicotinic modulation in VTA DA neurons. The objectives of this study were to investigate the effect of acute nicotine exposure on the VTA DA neuronal firing and to understand how the disruption of communication from PFC affects the firing patterns of VTA DA neurons. Extracellular single-unit recordings were performed on Sprague-Dawley rats and nicotine was administered after stable recording was established as baseline. In order to test how input from PFC affects the VTA DA neuronal firing, bilateral transections were made immediate caudal to PFC to mechanically delete the interaction between VTA and PFC. The complexity of the recorded neural firing was subsequently assessed using a method based on the Lempel-Ziv estimator. The results were compared with those obtained when computing the entropy of neural firing. Exposure to nicotine triggered a significant increase in VTA DA neurons firing complexity when communication between PFC and VTA was present, while transection obliterated the effect of nicotine. Similar results were obtained when entropy values were estimated. Our findings suggest that PFC plays a vital role in mediating VTA activity. We speculate that increased firing complexity with acute nicotine administration in PFC intact subjects is due to the close functional coupling between PFC and VTA. This hypothesis is supported by the fact that deletion of PFC results in minor alterations of VTA DA neural firing when nicotine is acutely administered.

Preclinical and Clinical Studies Demonstrate That the Proprietary Herbal Extract DA-5512 Effectively Stimulates Hair Growth and Promotes Hair Health.

PubMed

Yu, Jae Young; Gupta, Biki; Park, Hyoung Geun; Son, Miwon; Jun, Joon-Ho; Yong, Chul Soon; Kim, Jeong Ah; Kim, Jong Oh

2017-01-01

The proprietary DA-5512 formulation comprises six herbal extracts from traditional oriental plants historically associated with therapeutic and other applications related to hair. Here, we investigated the effects of DA-5512 on the proliferation of human dermal papilla cells (hDPCs) in vitro and on hair growth in C57BL/6 mice and conducted a clinical study to evaluate the efficacy and safety of DA-5512. DA-5512 significantly enhanced the viability of hDPCs in a dose-dependent manner ( p < 0.05), and 100 ppm of DA-5512 and 1  μ M minoxidil (MXD) significantly increased the number of Ki-67-positive cells, compared with the control group ( p < 0.05). MXD (3%) and DA-5512 (1%, 5%) significantly stimulated hair growth and increased the number and length of hair follicles (HFs) versus the controls (each p < 0.05). The groups treated with DA-5512 exhibited hair growth comparable to that induced by MXD. In clinical study, we detected a statistically significant increase in the efficacy of DA-5512 after 16 weeks compared with the groups treated with placebo or 3% MXD ( p < 0.05). In conclusion, DA-5512 might promote hair growth and enhance hair health and can therefore be considered an effective option for treating hair loss.

The da Vinci telerobotic surgical system: the virtual operative field and telepresence surgery.

PubMed

Ballantyne, Garth H; Moll, Fred

2003-12-01

The United States Department of Defense developed the telepresence surgery concept to meet battlefield demands. The da Vinci telerobotic surgery system evolved from these efforts. In this article, the authors describe the components of the da Vinci system and explain how the surgeon sits at a computer console, views a three-dimensional virtual operative field, and performs the operation by controlling robotic arms that hold the stereoscopic video telescope and surgical instruments that simulate hand motions with seven degrees of freedom. The three-dimensional imaging and handlike motions of the system facilitate advanced minimally invasive thoracic, cardiac, and abdominal procedures. da Vinci has recently released a second generation of telerobots with four arms and will continue to meet the evolving challenges of surgery.

Biochemical characterization of the 49 kDa penicillin-binding protein of Mycobacterium smegmatis.

PubMed Central

Mukherjee, T; Basu, D; Mahapatra, S; Goffin, C; van Beeumen, J; Basu, J

1996-01-01

The 49 kDa penicillin-binding protein (PBP) of Mycobacterium smegmatis catalyses the hydrolysis of the peptide or S-ester bond of carbonyl donors R1-CONH-CHR2-COX-CHR2-COO- (where X is NH or S). In the presence of a suitable amino acceptor, the reaction partitions between the transpeptidation and hydrolysis pathways, with the amino acceptor, behaving as a simple alternative nucleophile at the level of the acyl-enzyme. By virtue of its N-terminal sequence similarity, the 49 kDa PBP represents one of the class of monofunctional low-molecular-mass PBPs. An immunologically related protein of M(r) 52,000 is present in M. tuberculosis. The 49 kDa PBP is sensitive towards amoxycillin, imipenem, flomoxef and cefoxitin. PMID:8947487

Hurricane destructive power predictions based on historical storm and sea surface temperature data.

PubMed

Bogen, Kenneth T; Jones, Edwin D; Fischer, Larry E

2007-12-01

Forecasting destructive hurricane potential is complicated by substantial, unexplained intraannual variation in storm-specific power dissipation index (PDI, or integrated third power of wind speed), and interannual variation in annual accumulated PDI (APDI). A growing controversy concerns the recent hypothesis that the clearly positive trend in North Atlantic Ocean (NAO) sea surface temperature (SST) since 1970 explains increased hurricane intensities over this period, and so implies ominous PDI and APDI growth as global warming continues. To test this "SST hypothesis" and examine its quantitative implications, a combination of statistical and probabilistic methods were applied to National Hurricane Center HURDAT best-track data on NAO hurricanes during 1880-2002, and corresponding National Oceanographic and Atmospheric Administration Extended Reconstruction SST estimates. Notably, hurricane behavior was compared to corresponding hurricane-specific (i.e., spatiotemporally linked) SST; previous similar comparisons considered only SST averaged over large NAO regions. Contrary to the SST hypothesis, SST was found to vary in a monthly pattern inconsistent with that of corresponding PDI, and to be at best weakly associated with PDI or APDI despite strong correlation with corresponding mean latitude (R(2)= 0.55) or with combined mean location and a approximately 90-year periodic trend (R(2)= 0.70). Over the last century, the lower 75% of APDIs appear randomly sampled from a nearly uniform distribution, and the upper 25% of APDIs from a nearly lognormal distribution. From the latter distribution, a baseline (SST-independent) stochastic model was derived predicting that over the next half century, APDI will not likely exceed its maximum value over the last half century by more than a factor of 1.5. This factor increased to 2 using a baseline model modified to assume SST-dependence conditioned on an upper bound of the increasing NAO SST trend observed since 1970. An

A switch in the Atlantic Oscillation correlates with inter-annual changes in foraging location and food habits of Macaronesian shearwaters (Puffinus baroli) nesting on two islands of the sub-tropical Atlantic Ocean

NASA Astrophysics Data System (ADS)

Ramos, Jaime A.; Isabel Fagundes, Ana; Xavier, José C.; Fidalgo, Vera; Ceia, Filipe R.; Medeiros, Renata; Paiva, Vitor H.

2015-10-01

Changes in oceanographic conditions, shaped by changes in large-scale atmospheric phenomena such as the North Atlantic Oscillation (NAO), alters the structure and functioning of marine ecosystems. Such signals are readily captured by marine top predators, given that their use of foraging habitats and diets change when the NAO changes. In this study we assessed sexual, seasonal and annual (2010/11-2012/13) differences in diet, trophic and isotopic niche (using δ15N and δ13C values of whole blood, 1st primary, 8th secondary and breast feathers), foraging locations and oceanographic variation within foraging areas for Macaronesian shearwaters' (Puffinus baroli) during two years of contrasting NAO values, and between two sub-tropical islands 330 km apart in the North Atlantic Ocean, Cima Islet and Selvagem Grande. These two locations provide contrasting oceanographic foraging regimes for the birds, because the second colony is much closer to the African coast (375 vs 650 km), and, therefore, to the upwelling area of the Canary Current. There was a marked environmental perturbation in 2010/2011, related with a negative NAO Index and lower marine productivity (lower concentration of Chlorophyll a). This event corresponded to the Macaronesian shearwaters feeding farther north and west, which was readily seen in change of both δ15N and δ13C values, and in a higher intake of cephalopods. Diet and stable isotopes did not differ between sexes. Regurgitation analysis indicate a dominance of cephalopods in both islands, but prey fish were important for Selvagem Grande in 2012 and cephalopods for Cima Islet in 2011. Both δ15N and δ13C values were significantly higher for Cima Islet than for Selvagem Grande, irrespective of year, season and tissue sampled. SIBER analysis showed smaller isotopic niches for the breeding period. Our study suggests that during years of poor environmental conditions Macaronesian shearwaters shift their foraging location to more pelagic waters

Sequence and expression variations suggest an adaptive role for the DA1-like gene family in the evolution of soybeans.

PubMed

Zhao, Man; Gu, Yongzhe; He, Lingli; Chen, Qingshan; He, Chaoying

2015-05-15

The DA1 gene family is plant-specific and Arabidopsis DA1 regulates seed and organ size, but the functions in soybeans are unknown. The cultivated soybean (Glycine max) is believed to be domesticated from the annual wild soybeans (Glycine soja). To evaluate whether DA1-like genes were involved in the evolution of soybeans, we compared variation at both sequence and expression levels of DA1-like genes from G. max (GmaDA1) and G. soja (GsoDA1). Sequence identities were extremely high between the orthologous pairs between soybeans, while the paralogous copies in a soybean species showed a relatively high divergence. Moreover, the expression variation of DA1-like paralogous genes in soybean was much greater than the orthologous gene pairs between the wild and cultivated soybeans during development and challenging abiotic stresses such as salinity. We further found that overexpressing GsoDA1 genes did not affect seed size. Nevertheless, overexpressing them reduced transgenic Arabidopsis seed germination sensitivity to salt stress. Moreover, most of these genes could improve salt tolerance of the transgenic Arabidopsis plants, corroborated by a detection of expression variation of several key genes in the salt-tolerance pathways. Our work suggested that expression diversification of DA1-like genes is functionally associated with adaptive radiation of soybeans, reinforcing that the plant-specific DA1 gene family might have contributed to the successful adaption to complex environments and radiation of the plants.

Aerodynamic design of the Cal Poly Da Vinci Human-Powered Helicopter

NASA Technical Reports Server (NTRS)

Larwood, Scott; Saiki, Neal

1990-01-01

This paper will discuss the methodology used in designing the rotor and drive propellers for the third generation Cal Poly Da Vinci Human-Powered Helicopter. The rotor was designed using a lifting surface, uniform inflow hover analysis code and the propeller was designed using a minimum induced-loss method. Construction, geometry, and operating considerations are discussed as they impact the designs. Optimization of the design performance is also explained. The propellers were tested in a wind tunnel and results are compared with theoretical data. Successful flight tests of the Da Vinci III are discussed.

Left lower lobe sleeve lobectomy for lung cancer using the Da Vinci surgical system.

PubMed

Zhao, Yandong; Jiao, Wenjie; Ren, Xiaoyang; Zhang, Liangdong; Qiu, Tong; Fu, Bo; Wang, Lei

2016-04-12

Despite the robotic surgery is widely applied, sleeve lobectomy for lung cancer using the Da Vinci surgical system is still less performed. We described a sleeve lobectomy for adenocarcinoma located at the left lower lobe using the Da Vinci surgical system. A case of 57-year old female referred to our hospital. Computed tomography scan showed an occupation located at the left lower lobe and adenocarcinoma project from the lobe bronchus was diagnosed by bronchoscope examination. A sleeve lobectomy was performed using the Da Vinci surgical system and the postoperative recovery was uneventful. Robotic thoracic surgery is feasible to perform sleeve lobectomy inspite of inadequate experience.

75 FR 13486 - Availability of Grant Funds for Fiscal Year 2010; Amendment

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-22

.../NAO216_6_TOC.pdf , and the Council on Environmental Quality implementation regulations, http://ceq.eh.doe.gov/nepa/regs/ceq/toc_ceq.htm . Consequently, as part of an applicant's package, and under their...

46 CFR 340.2 - Definitions.

Code of Federal Regulations, 2010 CFR

2010-10-01

... means the Federal Emergency Management Agency. (j) NAO means the NSA Allocation Order, which is an order... Departmental Crisis Coordinator. (q) Secretarial Review means the process by which the Secretary or his or her...

Mid-Continent Expressions of Oceanic Teleconnections Evidenced in Red Pine Tree Rings