Symmetric and asymmetric capillary bridges between a rough surface and a parallel surface.

PubMed

Wang, Yongxin; Michielsen, Stephen; Lee, Hoon Joo

2013-09-03

Although the formation of a capillary bridge between two parallel surfaces has been extensively studied, the majority of research has described only symmetric capillary bridges between two smooth surfaces. In this work, an instrument was built to form a capillary bridge by squeezing a liquid drop on one surface with another surface. An analytical solution that describes the shape of symmetric capillary bridges joining two smooth surfaces has been extended to bridges that are asymmetric about the midplane and to rough surfaces. The solution, given by elliptical integrals of the first and second kind, is consistent with a constant Laplace pressure over the entire surface and has been verified for water, Kaydol, and dodecane drops forming symmetric and asymmetric bridges between parallel smooth surfaces. This solution has been applied to asymmetric capillary bridges between a smooth surface and a rough fabric surface as well as symmetric bridges between two rough surfaces. These solutions have been experimentally verified, and good agreement has been found between predicted and experimental profiles for small drops where the effect of gravity is negligible. Finally, a protocol for determining the profile from the volume and height of the capillary bridge has been developed and experimentally verified.

Oil shale processing as a source of aquatic pollution: monitoring of the biologic effects in caged and feral freshwater fish.

PubMed Central

Tuvikene, A; Huuskonen, S; Koponen, K; Ritola, O; Mauer, U; Lindström-Seppä, P

1999-01-01

The biologic effects of the oil shale industry on caged rainbow trout (Oncorhynchus mykiss) as well as on feral perch (Perca fluviatilis) and roach (Rutilus rutilus) were studied in the River Narva in northeast Estonia. The River Narva passes the oil shale mining and processing area and thus receives elevated amounts of polycyclic aromatic hydrocarbons (PAHs), heavy metals, and sulfates. The effects of the chemical load were monitored by measuring cytochrome P4501A (CYP1A)-dependent monooxygenase (MO) activities [7-ethoxyresorufin O-deethylase and aryl hydrocarbon hydroxylase (AHH)] as well as conjugation enzyme activities [glutathione S-transferase (GST) and UDP-glucuronosyltransferase] in the liver of fish. CYP1A induction was further studied by detecting the amount and occurrence of the CYP1A protein. Histopathology of tissues (liver, kidney, spleen, and intestine) and the percentage of micronuclei in fish erythrocytes were also determined. Selected PAHs and heavy metals (Cd, Cu, Hg, and Pb) were measured from fish muscle and liver. In spite of the significant accumulation of PAHs, there was no induction of MO activities in any studied fish species. When compared to reference samples, AHH activities were even decreased in feral fish at some of the exposed sites. Detection of CYP1A protein content and the distribution of the CYP1A enzyme by immunohistochemistry also did not show extensive CYP1A induction. Instead, GST activities were significantly increased at exposed sites. Detection of histopathology did not reveal major changes in the morphology of tissues. The micronucleus test also did not show any evidence of genotoxicity. Thus, from the parameters studied, GST activity was most affected. The lack of catalytic CYP1A induction in spite of the heavy loading of PAHs was not studied but has been attributed to the elevated content of other compounds such as heavy metals, some of which can act as inhibitors for MOs. Another possible explanation of this lack of induction is that through adaptation processes the fish could have lost some of their sensitivity to PAHs. Either complex pollution caused by oil shale processing masked part of the harmful effects measured in this study, or oil shale industry did not have any severe effects on fish in the River Narva. Our study illustrates the difficulties in estimating risk in cases where there are numerous various contaminants affecting the biota. Images Figure 1 Figure 2 PMID:10464075

A Hybrid Analysis for Security Protocols with State

DTIC Science & Technology

2014-07-16

Approved for Public Release; Distribution Unlimited. 14-1013. A Hybrid Analysis for Security Protocols with State∗ John D. Ramsdell Daniel J ...their consequences in the anno - tated protocol theory Tannot(Π, ) use only the limited vocabulary of Tbnd(Π); we call them bridge lemmas. Lemma 3 is a...and we proved it using pvs. Lemma 1 (Prefix Boot Extend). ∀π ∈ path, t :>, i, k ∈ N. i ≤ k ∧ π(k) has t ⊃ subterm(π(i), π(k)) ∨ ∃ j ∈ N. i ≤ j < k ∧ π

Vulnerability of bridges to scour: insights from an international expert elicitation workshop

NASA Astrophysics Data System (ADS)

Lamb, Rob; Aspinall, Willy; Odbert, Henry; Wagener, Thorsten

2017-08-01

Scour (localised erosion) during flood events is one of the most significant threats to bridges over rivers and estuaries, and has been the cause of numerous bridge failures, with damaging consequences. Mitigation of the risk of bridges being damaged by scour is therefore important to many infrastructure owners, and is supported by industry guidance. Even after mitigation, some residual risk remains, though its extent is difficult to quantify because of the uncertainties inherent in the prediction of scour and the assessment of the scour risk. This paper summarises findings from an international expert workshop on bridge scour risk assessment that explores uncertainties about the vulnerability of bridges to scour. Two specialised structured elicitation methods were applied to explore the factors that experts in the field consider important when assessing scour risk and to derive pooled expert judgements of bridge failure probabilities that are conditional on a range of assumed scenarios describing flood event severity, bridge and watercourse types and risk mitigation protocols. The experts' judgements broadly align with industry good practice, but indicate significant uncertainty about quantitative estimates of bridge failure probabilities, reflecting the difficulty in assessing the residual risk of failure. The data and findings presented here could provide a useful context for the development of generic scour fragility models and their associated uncertainties.

Sufficient Immunosuppression with Thymoglobulin Is Essential for a Successful Haplo-Myeloid Bridge in Haploidentical-Cord Blood Transplantation.

PubMed

Lindemans, Caroline A; Te Boome, Liane C J; Admiraal, Rick; Jol-van der Zijde, Els C; Wensing, Anne M; Versluijs, A Birgitta; Bierings, Marc B; Kuball, Jürgen; Boelens, Jaap J

2015-10-01

In haploidentical (haplo)-cord blood (CB) transplantations, early haplo donor engraftment serves as a myeloid bridge to sustainable CB engraftment and is associated with early neutrophil recovery. The conditioning regimens as published for haplo-cord protocols usually contain serotherapy, such as rabbit antithymocyte globulin (ATG) (Thymoglobulin, Genzyme, Cambridge, MA). However, reducing or omitting serotherapy is an important strategy to improve early immune reconstitution after transplantation. The need for serotherapy in successful haplo-cord transplantation, defined as having a haplo-derived myeloid bridge to CB engraftment, has not been investigated before. Two consecutive cohorts of patients underwent transplantation with haplo-CB. The first group underwent transplantation with haplo-CB for active infection and/or an underlying condition with expected difficult engraftment without a conventional donor available. They received a single unit (s) CB and haplo donor cells (CD34(+) selected, 5 × 10(6) CD34(+)/kg). The second cohort included patients with poor-risk malignancies, not eligible for other treatment protocols. They received a sCB and haplo donor cells (CD19/αβTCR-depleted; 5 × 10(6) CD34(+)/kg). Retrospectively in both cohorts, active ATG (Thymoglobulin) levels were measured and post-hematopoietic cell transplantation area under the curve (AUC) was calculated. The influence of ATG exposure for having a successful haplo-myeloid bridge (early haplo donor engraftment before CB engraftment and no secondary neutropenia) and transplantation-related mortality (TRM) were analyzed as primary endpoints. Twenty patients were included (16 in the first cohort and 4 in the second cohort). In 58% of evaluable patients, there was no successful haplo-derived myeloid bridge to CB engraftment, for which a low post-transplantation ATG exposure appeared to be a predictor (P <.001). TRM in the unsuccessful haplo-bridge group was 70% ± 16% versus 12% ± 12% in the successful haplo-bridge group (P = .012). In conclusion, sufficient in vivo T depletion with ATG is required for a successful haplo-myeloid bridge to CB engraftment. Copyright © 2015 American Society for Blood and Marrow Transplantation. Published by Elsevier Inc. All rights reserved.

Ileostomy rod--is it a bridge too far?

PubMed

Speirs, M; Leung, E; Hughes, D; Robertson, I; Donnelly, L; Mackenzie, I; Macdonald, A

2006-07-01

Defunctioning loop ileostomies are used commonly to protect low colorectal anastomoses and thereby reducing the serious complications of leakage. However, they are associated with specific complications such as retraction. Traditionally, a supporting rod is placed as a bridge to support both limbs of the stoma in the hope of reducing the incidence of stomal retraction. There is little evidence in the published literature to support this practice. The aim of this study was to determine whether using an ileostomy rod would reduce the incidence of stomal retraction. A prospective, randomised controlled trial was performed in 60 consecutive patients who required a defunctioning loop ileostomy. Patients were allocated to either a 'bridge' or 'bridge-less' protocol. All the patients were assessed by dedicated stoma nurses for at least 3 months and until their stomas were closed. Their postoperative symptoms, including stoma activity and retraction rate, were recorded. Between May 2001 and June 2004, 57 patients completed the study (28 bridge; 29 bridge-less). There were no significant differences in the retraction rate between the groups. No clinical anastomotic leakage was recorded and none of the patients required early closure. If a loop ileostomy is constructed properly, stomal retraction is uncommon and routine use of a bridge is unnecessary.

Local network assessment

NASA Astrophysics Data System (ADS)

Glen, D. V.

1985-04-01

Local networks, related standards activities of the Institute of Electrical and Electronics Engineers the American National Standards Institute and other elements are presented. These elements include: (1) technology choices such as topology, transmission media, and access protocols; (2) descriptions of standards for the 802 local area networks (LAN's); high speed local networks (HSLN's) and military specification local networks; and (3) intra- and internetworking using bridges and gateways with protocols Interconnection (OSI) reference model. The convergence of LAN/PBX technology is also described.

Nondestructive Inspection Protocol for Reinforced Concrete Barriers [Tech Brief

DOT National Transportation Integrated Search

2014-09-01

Reinforced concrete barriers are generally anchored to the deck of a bridge or retaining wall using reinforcing steel protruding from the main structure or by anchored bars or bolts added during retrofits. Corrosion of steel bars or bolts can weaken ...

Development of shrinkage limits and testing protocols for ODOT high performance concrete.

DOT National Transportation Integrated Search

2013-12-01

ODOT has observed varying degrees of cracking in their concrete structures. Cracking of high performance reinforced : concrete structures, in particular bridge decks, is of paramount concern to ODOT. Cracking at early ages (especially within : the fi...

Reminding-Based Learning

DTIC Science & Technology

1994-02-08

reasons. Second, they provide an important bridge between the huge amount of work on categorization to the much smaller body of work on problem...subjects talking more about relevant information compared to the neutral problems (i.e., a higher proption of the protocol statements concerned information

Synthesis of all-hydrocarbon stapled α-helical peptides by ring-closing olefin metathesis.

PubMed

Kim, Young-Woo; Grossmann, Tom N; Verdine, Gregory L

2011-06-01

This protocol provides a detailed procedure for the preparation of stapled α-helical peptides, which have proven their potential as useful molecular probes and as next-generation therapeutics. Two crucial features of this protocol are (i) the construction of peptide substrates containing hindered α-methyl, α-alkenyl amino acids and (ii) the ring-closing olefin metathesis (RCM) of the resulting resin-bound peptide substrates. The stapling systems described in this protocol, namely bridging one or two turns of an α-helix, are highly adaptable to most peptide sequences, resulting in favorable RCM kinetics, helix stabilization and promotion of cellular uptake.

A security proof of the round-robin differential phase shift quantum key distribution protocol based on the signal disturbance

NASA Astrophysics Data System (ADS)

Sasaki, Toshihiko; Koashi, Masato

2017-06-01

The round-robin differential phase shift (RRDPS) quantum key distribution (QKD) protocol is a unique QKD protocol whose security has not been understood through an information-disturbance trade-off relation, and a sufficient amount of privacy amplification was given independently of signal disturbance. Here, we discuss the security of the RRDPS protocol in the asymptotic regime when a good estimate of the bit error rate is available as a measure of signal disturbance. The uniqueness of the RRDPS protocol shows up as a peculiar form of information-disturbance trade-off curve. When the length of a block of pulses used for encoding and the signal disturbance are both small, it provides a significantly better key rate than that from the original security proof. On the other hand, when the block length is large, the use of the signal disturbance makes little improvement in the key rate. Our analysis will bridge a gap between the RRDPS protocol and the conventional QKD protocols.

TinyONet: A Cache-Based Sensor Network Bridge Enabling Sensing Data Reusability and Customized Wireless Sensor Network Services

PubMed Central

Jung, Eui-Hyun; Park, Yong-Jin

2008-01-01

In recent years, a few protocol bridge research projects have been announced to enable a seamless integration of Wireless Sensor Networks (WSNs) with the TCP/IP network. These studies have ensured the transparent end-to-end communication between two network sides in the node-centric manner. Researchers expect this integration will trigger the development of various application domains. However, prior research projects have not fully explored some essential features for WSNs, especially the reusability of sensing data and the data-centric communication. To resolve these issues, we suggested a new protocol bridge system named TinyONet. In TinyONet, virtual sensors play roles as virtual counterparts of physical sensors and they dynamically group to make a functional entity, Slice. Instead of direct interaction with individual physical sensors, each sensor application uses its own WSN service provided by Slices. If a new kind of service is required in TinyONet, the corresponding function can be dynamically added at runtime. Beside the data-centric communication, it also supports the node-centric communication and the synchronous access. In order to show the effectiveness of the system, we implemented TinyONet on an embedded Linux machine and evaluated it with several experimental scenarios. PMID:27873968

Bacterial molecular networks: bridging the gap between functional genomics and dynamical modelling.

PubMed

van Helden, Jacques; Toussaint, Ariane; Thieffry, Denis

2012-01-01

This introductory review synthesizes the contents of the volume Bacterial Molecular Networks of the series Methods in Molecular Biology. This volume gathers 9 reviews and 16 method chapters describing computational protocols for the analysis of metabolic pathways, protein interaction networks, and regulatory networks. Each protocol is documented by concrete case studies dedicated to model bacteria or interacting populations. Altogether, the chapters provide a representative overview of state-of-the-art methods for data integration and retrieval, network visualization, graph analysis, and dynamical modelling.

Effect of negative mechanical stress on the orientation of myosin cross-bridges in muscle fibers.

PubMed Central

Burghardt, T P; Ajtai, K

1989-01-01

The effect of positive and negative stress on myosin cross-bridge orientation in glycerinated muscle fibers was investigated by using fluorescence polarization spectroscopy of the emission from the covalent label tetramethyl-rhodamine-5-(and -6)-iodoacetamide (IATR) specifically modifying sulfhydryl one (SH1) on the myosin heavy chain. Positive tension was applied by stretching the fiber in rigor. Negative tension was applied in two steps by using a protocol introduced by Goldman et al. [Goldman, Y. E., McCray, J. A. & Vallette, D. P. (1988) J. Physiol. (London) 398, 75P]: relaxing a fiber at resting length and stretching it until the relaxed tension is appreciable and then placing the fiber in rigor and releasing the tension onto the rigor cross-bridges. We found, as have others, that positive tension has no effect on the fluorescence polarization spectrum from the SH1-bound probe, indicating that the cross-bridge does not rotate under these conditions. Negative tension, however, causes a change in the fluorescence polarization spectrum that indicates a probe rotation. The changes in the polarization spectrum from negative stress are partially reversed by the subsequent application of positive stress. It appears that negative tension strains the cross-bridge, or the cross-bridge domain containing SH1, and causes it to rotate. Images PMID:2526336

Online Bridge Crack Monitoring with Smart Film

PubMed Central

Wang, Shuliang; Li, Xingxing; Zhou, Zhixiang; Zhang, Xu; Yang, Guang; Qiu, Minfeng

2013-01-01

Smart film crack monitoring method, which can be used for detecting initiation, length, width, shape, location, and propagation of cracks on real bridges, is proposed. Firstly, the fabrication of the smart film is developed. Then the feasibility of the method is analyzed and verified by the mechanical sensing character of the smart film under the two conditions of normal strain and crack initiation. Meanwhile, the coupling interference between parallel enameled wires of the smart film is discussed, and then low-frequency detecting signal and the custom communication protocol are used to decrease interference. On this basis, crack monitoring system with smart film is designed, where the collected crack data is sent to the remote monitoring center and the cracks are simulated and recurred. Finally, the monitoring system is applied to six bridges, and the effects are discussed. PMID:24489496

Improving home-based providers' communication to primary care providers to enhance care coordination.

PubMed

Gum, Amber M; Dautovich, Natalie D; Greene, Jennifer; Hirsch, Anne; Schonfeld, Lawrence

2015-01-01

Health care system fragmentation is a pervasive problem. Research has not delineated concrete behavioral strategies to guide providers to communicate with personnel in other organizations to coordinate care. We addressed this gap within a particular context: home-based providers delivering depression care management (DCM) to older adults requiring coordination with primary care personnel. Our objective was to pilot test a communication protocol ('BRIDGE - BRinging Inter-Disciplinary Guidelines to Elders') in conjunction with DCM. In an open pilot trial (N = 7), home-based providers delivered DCM to participants. Following the BRIDGE protocol, home-based providers made scripted telephone calls and sent structured progress reports to personnel in participants' primary care practices with concise information and requests for assistance. Home-based providers documented visits with participants, contacts to and responses from primary care personnel. A research interviewer assessed participant outcomes [Symptom Checklist-20 (depressive symptoms), World Health Organization Disability Assessment Schedule-12, satisfaction] at baseline, three months, and six months. Over 12 months, home-based providers made 2.4 telephone calls and sent 6.3 faxes to other personnel, on average per participant. Primary care personnel responded to 18 of 22 requests (81.8%; 2 requests dropped, 2 ongoing), with at least one response per participant. Participants' depressive symptoms and disability improved significantly at both post-tests with large effect sizes (d ranged 0.73-2.3). Participants were satisfied. Using BRIDGE, home-based providers expended a small amount of effort to communicate with primary care personnel, who responded to almost all requests. Larger scale research is needed to confirm findings and potentially extend BRIDGE to other client problems, professions, and service sectors.

The use of shale ash in dry mix construction materials

NASA Astrophysics Data System (ADS)

Gulbe, L.; Setina, J.; Juhnevica, I.

2017-10-01

The research was made to determine the use of shale ash usage in dry mix construction materials by replacing part of cement amount. Cement mortar ZM produced by SIA Sakret and two types of shale ashes from Narva Power plant (cyclone ash and electrostatic precipitator ash) were used. Fresh mortar properties, hardened mortar bulk density, thermal conductivity (λ10, dry) (table value) were tested in mortar ZM samples and mortar samples in which 20% of the amount of cement was replaced by ash. Compressive strenght, frost resistance and resistance to sulphate salt solutions were checked. It was stated that the use of electrostatic precipitator ash had a little change of the material properties, but the cyclone ash significantly reduced the mechanical strength of the material.

Smart Rocks for Bridge Scour Monitoring: Design and Localization Using Electromagnetic Techniques and Embedded Orientation Sensors

NASA Astrophysics Data System (ADS)

Radchenko, Andro

River bridge scour is an erosion process in which flowing water removes sediment materials (such as sand, rocks) from a bridge foundation, river beds and banks. As a result, the level of the river bed near a bridge pier is lowering such that the bridge foundation stability can be compromised, and the bridge can collapse. The scour is a dynamic process, which can accelerate rapidly during a flood event. Thus, regular monitoring of the scour progress is necessary to be performed at most river bridges. Present techniques are usually expensive, require large man/hour efforts, and often lack the real-time monitoring capabilities. In this dissertation a new method--'Smart Rocks Network for bridge scour monitoring' is introduced. The method is based on distributed wireless sensors embedded in ground underwater nearby the bridge pillars. The sensor nodes are unconstrained in movement, are equipped with years-lasting batteries and intelligent custom designed electronics, which minimizes power consumption during operation and communication. The electronic part consists of a microcontroller, communication interfaces, orientation and environment sensors (such as are accelerometer, magnetometer, temperature and pressure sensors), supporting power supplies and circuitries. Embedded in the soil nearby a bridge pillar the Smart Rocks can move/drift together with the sediments, and act as the free agent probes transmitting the unique signature signals to the base-station monitors. Individual movement of a Smart Rock can be remotely detected processing the orientation sensors reading. This can give an indication of the on-going scour progress, and set a flag for the on-site inspection. The map of the deployed Smart Rocks Network can be obtained utilizing the custom developed in-network communication protocol with signals intensity (RSSI) analysis. Particle Swarm Optimization (PSO) is applied for map reconstruction. Analysis of the map can provide detailed insight into the scour progress and topology. Smart Rocks Network wireless communication is based on the magnetoinductive (MI) link, at low (125 KHz) frequency, allowing for signal to penetrate through the water, rocks, and the bridge structure. The dissertation describes the Smart Rocks Network implementation, its electronic design and the electromagnetic/computational intelligence techniques used for the network mapping.

MSFC institutional area network and ATM technology

NASA Technical Reports Server (NTRS)

Amin, Ashok T.

1994-01-01

The New Institutional Area Network (NEWIAN) at Marshall supports over 5000 end users with access to 26 file servers providing work presentation services. It is comprised of some 150 Ethernet LAN's interconnected by bridges/routers which are in turn connected to servers over two dual FDDI rings. The network supports various higher level protocols such as IP, IPX, AppleTalk (AT), and DECNet. At present IPX and AT protocols packets are routed, and IP protocol packets are bridged; however, work is in progress to route all IP packets. The impact of routing IP packets on network operation is examined. Broadband Integrated Services Data Network (BISDN), presently at various stages of development, is intended to provide voice, video, and data transfer services over a single network. BISDN will use asynchronous transfer mode (ATM) as a data transfer technique which provides for transmission, multiplexing, switching, and relaying of small size data units called cells. Limited ATM Wide Area Network (WAN) services are offered by Wiltel, AT&T, Sprint, and others. NASA is testing a pilot ATM WAN with a view to provide Program Support Communication Network services using ATM. ATM supports wide range of data rates and quality of service requirements. It is expected that ATM switches will penetrate campus networks as well. However, presently products in these areas are at various stages of development and standards are not yet complete. We examine development of ATM to help assess its role in the evolution of NEWIAN.

Protocols for Molecular Dynamics Simulations of RNA Nanostructures.

PubMed

Kim, Taejin; Kasprzak, Wojciech K; Shapiro, Bruce A

2017-01-01

Molecular dynamics (MD) simulations have been used as one of the main research tools to study a wide range of biological systems and bridge the gap between X-ray crystallography or NMR structures and biological mechanism. In the field of RNA nanostructures, MD simulations have been used to fix steric clashes in computationally designed RNA nanostructures, characterize the dynamics, and investigate the interaction between RNA and other biomolecules such as delivery agents and membranes.In this chapter we present examples of computational protocols for molecular dynamics simulations in explicit and implicit solvent using the Amber Molecular Dynamics Package. We also show examples of post-simulation analysis steps and briefly mention selected tools beyond the Amber package. Limitations of the methods, tools, and protocols are also discussed. Most of the examples are illustrated for a small RNA duplex (helix), but the protocols are applicable to any nucleic acid structure, subject only to the computational speed and memory limitations of the hardware available to the user.

Signal identification in acoustic emission monitoring of fatigue cracking in steel bridges

NASA Astrophysics Data System (ADS)

Yu, Jianguo P.; Ziehl, Paul; Pollock, Adrian

2012-04-01

Signal identification including noise filtering and reduction of acquired signals is needed to achieve efficient and accurate data interpretation for remote acoustic emission (AE) monitoring of in-service steel bridges. Noise filtering may ensure that genuine hits from crack growth are involved in the estimation of fatigue damage and remaining fatigue life. Reduction of the data quantity is desirable for the sensing system to conserve energy in the data transmission and processing procedures. Identification and categorization of acquired signals is a promising approach to effectively filter and reduce AE data in the application of bridge monitoring. In this study an investigation on waveform features (time domain and frequency domain) and relevant filters is carried out using the results from AE monitored fatigue tests. It is verified that duration-amplitude (D-A) filters are effective to discriminate against noise for results of steel fatigue tests. The study is helpful to find an appropriate AE data filtering protocol for field implementations.

A simple protocol using underwater epoxy to install annual temperature monitoring sites in rivers and streams

Treesearch

Daniel J. Isaak; Dona L. Horan; Sherry P. Wollrab

2013-01-01

Thermal regimes in rivers and streams are fundamental determinants of biological processes and are often monitored for regulatory compliance. Here, we describe a simple technique for establishing annual monitoring sites that uses underwater epoxy to attach miniature sensors to large rocks and cement bridge supports, which then serve as protective anchors. More than 500...

Molecular Docking, Molecular Dynamics Simulations, Computational Screening to Design Quorum Sensing Inhibitors Targeting LuxP of Vibrio harveyi and Its Biological Evaluation.

PubMed

Rajamanikandan, Sundaraj; Jeyakanthan, Jeyaraman; Srinivasan, Pappu

2017-01-01

Quorum sensing (QS) plays an important role in the biofilm formation, production of virulence factors and stress responses in Vibrio harveyi. Therefore, interrupting QS is a possible approach to modulate bacterial behavior. In the present study, three docking protocols, such as Rigid Receptor Docking (RRD), Induced Fit Docking (IFD), and Quantum Polarized Ligand Docking (QPLD) were used to elucidate the binding mode of boronic acid derivatives into the binding pocket of LuxP protein in V. harveyi. Among the three docking protocols, IFD accurately predicted the correct binding mode of the studied inhibitors. Molecular dynamics (MD) simulations of the protein-ligand complexes indicates that the inter-molecular hydrogen bonds formed between the protein and ligand complex remains stable during the simulation time. Pharmacophore and shape-based virtual screening were performed to find selective and potent compounds from ChemBridge database. Five hit compounds were selected and subjected to IFD and MD simulations to validate the binding mode. In addition, enrichment calculation was performed to discriminate and separate active compounds from the inactive compounds. Based on the computational studies, the potent Bicyclo [2.2.1] hept-5-ene-2,3-dicarboxylic acid-2,6-dimethylpyridine 1-oxide (ChemBridge_5144368) was selected for in vitro assays. The compound exhibited dose dependent inhibition in bioluminescence and also inhibits biofilm formation in V. harveyi to the level of 64.25 %. The result from the study suggests that ChemBridge_5144368 could serve as an anti-quorum sensing molecule for V. harveyi.

Development of Virtual Resource Based IoT Proxy for Bridging Heterogeneous Web Services in IoT Networks.

PubMed

Jin, Wenquan; Kim, DoHyeun

2018-05-26

The Internet of Things is comprised of heterogeneous devices, applications, and platforms using multiple communication technologies to connect the Internet for providing seamless services ubiquitously. With the requirement of developing Internet of Things products, many protocols, program libraries, frameworks, and standard specifications have been proposed. Therefore, providing a consistent interface to access services from those environments is difficult. Moreover, bridging the existing web services to sensor and actuator networks is also important for providing Internet of Things services in various industry domains. In this paper, an Internet of Things proxy is proposed that is based on virtual resources to bridge heterogeneous web services from the Internet to the Internet of Things network. The proxy enables clients to have transparent access to Internet of Things devices and web services in the network. The proxy is comprised of server and client to forward messages for different communication environments using the virtual resources which include the server for the message sender and the client for the message receiver. We design the proxy for the Open Connectivity Foundation network where the virtual resources are discovered by the clients as Open Connectivity Foundation resources. The virtual resources represent the resources which expose services in the Internet by web service providers. Although the services are provided by web service providers from the Internet, the client can access services using the consistent communication protocol in the Open Connectivity Foundation network. For discovering the resources to access services, the client also uses the consistent discovery interface to discover the Open Connectivity Foundation devices and virtual resources.

Reduced exposure evaluation of an Electrically Heated Cigarette Smoking System. Part 8: Nicotine bridging--estimating smoke constituent exposure by their relationships to both nicotine levels in mainstream cigarette smoke and in smokers.

PubMed

Urban, H-Jörg; Tricker, Anthony R; Leyden, Donald E; Forte, Natasa; Zenzen, Volker; Feuersenger, Astrid; Assink, Mareike; Kallischnigg, Gerd; Schorp, Matthias K

2012-11-01

A modeling approach termed 'nicotine bridging' is presented to estimate exposure to mainstream smoke constituents. The method is based on: (1) determination of harmful and potentially harmful constituents (HPHC) and in vitro toxicity parameter-to-nicotine regressions obtained using multiple machine-smoking protocols, (2) nicotine uptake distributions determined from 24-h excretion of nicotine metabolites in a clinical study, and (3) modeled HPHC uptake distributions using steps 1 and 2. An example of 'nicotine bridging' is provided, using a subset of the data reported in Part 2 of this supplement (Zenzen et al., 2012) for two conventional lit-end cigarettes (CC) and the Electrically Heated Cigarette Smoking System (EHCSS) series-K6 cigarette. The bridging method provides justified extrapolations of HPHC exposure distributions that cannot be obtained for smoke constituents due to the lack of specific biomarkers of exposure to cigarette smoke constituents in clinical evaluations. Using this modeling approach, exposure reduction is evident when the HPHC exposure distribution curves between the MRTP and the CC users are substantially separated with little or no overlap between the distribution curves. Copyright © 2012 Elsevier Inc. All rights reserved.

Is there a role for upper-extremity intra-aortic balloon counterpulsation as a bridge-to-recovery or a bridge-to-transplant in the treatment of end-stage heart failure?

PubMed

Nwaejike, Nnamdi; Son, Andre Y; Milano, Carmelo A; Daneshmand, Mani A

2017-10-01

A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was: Is there a role for upper-extremity intra-aortic balloon pump counterpulsation (UE-IABP) in the treatment of end-stage heart failure? Altogether 230 papers were found using the reported search, of which 6 papers represented the best evidence to answer the clinical question. The authors, journal, date and country of publication, patient group studied, study type, relevant outcomes and results of these papers are tabulated. Of the 163 bridge-to-transplantation (BTT) patients, 141 (86.5%) were successfully transplanted and of the 9 bridge-to-recovery (BTR) patients, 6 (66.7%) were successfully weaned from the device. Length of support ranged from 3 to 152 days, and the most frequent complications were device malfunction or migration necessitating exchange or repositioning, occurring at a collective rate of 37.3%. UE-IABP is a minimally invasive and cost-effective strategy that provides haemodynamic support while preserving both the mediastinum and the functional status in BTR and BTT patients who may not tolerate more invasive modes of mechanical circulatory support. We conclude that UE-IABP can be used as a bridge-to-recovery (BTR) or transplant (BTT) in patients with end-stage heart failure. © The Author 2017. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.

Experimental and Analytical Seismic Studies of a Four-Span Bridge System with Innovative Materials

NASA Astrophysics Data System (ADS)

Cruz Noguez, Carlos Alonso

As part of a multi-university project utilizing the NSF Network for Earthquake Engineering Simulation (NEES), a quarter-scale model of a four-span bridge incorporating plastic hinges with different advanced materials was tested to failure on the three shake table system at the University of Nevada, Reno (UNR). The bridge was the second test model in a series of three 4-span bridges, with the first model being a conventional reinforced-concrete (RC) structure. The purpose of incorporating advanced materials was to improve the seismic performance of the bridge with respect to two damage indicators: (1) column damage and (2) permanent deformations. The goals of the study presented in this document were to (1) evaluate the seismic performance of a 4-span bridge system incorporating SMA/ECC and built-in rubber pad plastic hinges as well as post-tensioned piers, (2) quantify the relative merit of these advanced materials and details compared to each other and to conventional reinforced concrete plastic hinges, (3) determine the influence of abutment-superstructure interaction on the response, (4) examine the ability of available elaborate analytical modeling techniques to model the performance of advanced materials and details, and (5) conduct an extensive parametric study of different variations of the bridge model to study several important issues in bridge earthquake engineering. The bridge model included six columns, each pair of which utilized a different advanced detail at bottom plastic hinges: shape memory alloys (SMA), special engineered cementitious composites (ECC), elastomeric pads embedded into columns, and post-tensioning tendons. The design of the columns, location of the bents, and selection of the loading protocol were based on pre-test analyses conducted using computer program OpenSees. The bridge model was subjected to two-horizontal components of simulated earthquake records of the 1994 Northridge earthquake. Over 340 channels of data were collected. The test results showed the effectiveness of the advanced materials in reducing damage and permanent displacements. The damage was minimal in plastic hinges with SMA/ECC and those with built-in elastomeric pads. Conventional RC plastic hinges were severely damaged due to spalling of concrete and rupture of the longitudinal and transverse reinforcement. Extensive post-test analytical studies were conducted and it was determined that a computational model of the bridge that included bridge-abutment interaction using OpenSees was able to provide satisfactory estimations of key structural parameters such as superstructure displacements and base shears. The analytical model was also used to conduct parametric studies on single-column and bridge-system response under near-fault ground motions. The effects of vertical excitations and transverse shear-keys at the bridge abutments on the superstructure displacement and column drifts were also explored.

ROS-IGTL-Bridge: an open network interface for image-guided therapy using the ROS environment.

PubMed

Frank, Tobias; Krieger, Axel; Leonard, Simon; Patel, Niravkumar A; Tokuda, Junichi

2017-08-01

With the growing interest in advanced image-guidance for surgical robot systems, rapid integration and testing of robotic devices and medical image computing software are becoming essential in the research and development. Maximizing the use of existing engineering resources built on widely accepted platforms in different fields, such as robot operating system (ROS) in robotics and 3D Slicer in medical image computing could simplify these tasks. We propose a new open network bridge interface integrated in ROS to ensure seamless cross-platform data sharing. A ROS node named ROS-IGTL-Bridge was implemented. It establishes a TCP/IP network connection between the ROS environment and external medical image computing software using the OpenIGTLink protocol. The node exports ROS messages to the external software over the network and vice versa simultaneously, allowing seamless and transparent data sharing between the ROS-based devices and the medical image computing platforms. Performance tests demonstrated that the bridge could stream transforms, strings, points, and images at 30 fps in both directions successfully. The data transfer latency was <1.2 ms for transforms, strings and points, and 25.2 ms for color VGA images. A separate test also demonstrated that the bridge could achieve 900 fps for transforms. Additionally, the bridge was demonstrated in two representative systems: a mock image-guided surgical robot setup consisting of 3D slicer, and Lego Mindstorms with ROS as a prototyping and educational platform for IGT research; and the smart tissue autonomous robot surgical setup with 3D Slicer. The study demonstrated that the bridge enabled cross-platform data sharing between ROS and medical image computing software. This will allow rapid and seamless integration of advanced image-based planning/navigation offered by the medical image computing software such as 3D Slicer into ROS-based surgical robot systems.

Entanglement routers via a wireless quantum network based on arbitrary two qubit systems

NASA Astrophysics Data System (ADS)

Metwally, N.

2014-12-01

A wireless quantum network is generated between multi-hops, where each hop consists of two entangled nodes. These nodes share a finite number of entangled two-qubit systems randomly. Different types of wireless quantum bridges (WQBS) are generated between the non-connected nodes. The efficiency of these WQBS to be used as quantum channels between its terminals to perform quantum teleportation is investigated. We suggest a theoretical wireless quantum communication protocol to teleport unknown quantum signals from one node to another, where the more powerful WQBS are used as quantum channels. It is shown that, by increasing the efficiency of the sources that emit the initial partial entangled states, one can increase the efficiency of the wireless quantum communication protocol.

Effect of muscle length on cross-bridge kinetics in intact cardiac trabeculae at body temperature.

PubMed

Milani-Nejad, Nima; Xu, Ying; Davis, Jonathan P; Campbell, Kenneth S; Janssen, Paul M L

2013-01-01

Dynamic force generation in cardiac muscle, which determines cardiac pumping activity, depends on both the number of sarcomeric cross-bridges and on their cycling kinetics. The Frank-Starling mechanism dictates that cardiac force development increases with increasing cardiac muscle length (corresponding to increased ventricular volume). It is, however, unclear to what extent this increase in cardiac muscle length affects the rate of cross-bridge cycling. Previous studies using permeabilized cardiac preparations, sub-physiological temperatures, or both have obtained conflicting results. Here, we developed a protocol that allowed us to reliably and reproducibly measure the rate of tension redevelopment (k(tr); which depends on the rate of cross-bridge cycling) in intact trabeculae at body temperature. Using K(+) contractures to induce a tonic level of force, we showed the k(tr) was slower in rabbit muscle (which contains predominantly β myosin) than in rat muscle (which contains predominantly α myosin). Analyses of k(tr) in rat muscle at optimal length (L(opt)) and 90% of optimal length (L(90)) revealed that k(tr) was significantly slower at L(opt) (27.7 ± 3.3 and 27.8 ± 3.0 s(-1) in duplicate analyses) than at L(90) (45.1 ± 7.6 and 47.5 ± 9.2 s(-1)). We therefore show that k(tr) can be measured in intact rat and rabbit cardiac trabeculae, and that the k(tr) decreases when muscles are stretched to their optimal length under near-physiological conditions, indicating that the Frank-Starling mechanism not only increases force but also affects cross-bridge cycling kinetics.

Knotted versus knotless suture bridge repair of the achilles tendon insertion: a biomechanical study.

PubMed

Cox, Joseph T; Shorten, Peter L; Gould, Gregory C; Markert, Ronald J; Barnett, Michael D; Laughlin, Richard T

2014-11-01

Surgical treatment of insertional Achilles tendinopathy often involves detachment and debridement of the Achilles tendon insertion. A recent study has shown that knotted suture bridge fixation of the Achilles to the calcaneus is biomechanically superior to single-row fixation, but there is an absence of literature on the use of different suture bridge constructs to repair the Achilles tendon. There will be no significant difference in the load to failure, mode of failure, tendon strain, tendon stiffness, repair site gapping, or footprint size when comparing knotted suture bridge repair to knotless suture bridge repair of the Achilles tendon after detachment for insertional Achilles tendinopathy. Controlled laboratory study. A single specimen from each pair of 10 cadaveric Achilles tendons was randomized to 1 of 2 Achilles insertion repair groups: knotted (n = 10) or knotless (n = 10) suture bridge repair. Repaired footprint size was measured, and then cyclic testing from 10 to 100 N for 2000 cycles was performed. This was followed by measurement of tendon strain, repair site displacement, load to failure, and tendon stiffness. The knotted suture bridge repair had a significantly higher load to failure compared with the knotless suture bridge (mean ± SD, 317.8 ± 93.6 N vs 196.1 ± 12.1 N, respectively; P = .001). All constructs failed at the tendon-suture interface. Tendon strain after cyclic testing was significantly greater in the knotless (1.20 ± 1.05) compared with the knotted (0.39 ± 0.4) suture repair groups (P = .011). There was no significant difference in footprint size between the knotted (230.3 ± 63.3 mm(2)) and knotless (248.5 ± 48.8 mm(2)) groups (P = .40). There was also no significant difference in stiffness (knotted = 76.4 ± 8.0 N/mm; knotless = 69.6 ± 10.9 N/mm; P = .17) and repair site displacement after cyclic testing (knotted = 2.8 ± 1.2 mm; knotless = 3.6 ± 1.1 mm; P = .17). During suture bridge repair of the Achilles tendon after detachment, knots at the proximal suture anchors significantly improve the biomechanical strength of the repair. This study demonstrated that the knotless suture bridge repair had a significantly lower load to failure than the knotted suture bridge. Surgeons should be aware of these biomechanical differences, as they influence the postoperative rehabilitation protocol and may lead to higher surgical complication rates. © 2014 The Author(s).

Protocols for Image Processing based Underwater Inspection of Infrastructure Elements

NASA Astrophysics Data System (ADS)

O'Byrne, Michael; Ghosh, Bidisha; Schoefs, Franck; Pakrashi, Vikram

2015-07-01

Image processing can be an important tool for inspecting underwater infrastructure elements like bridge piers and pile wharves. Underwater inspection often relies on visual descriptions of divers who are not necessarily trained in specifics of structural degradation and the information may often be vague, prone to error or open to significant variation of interpretation. Underwater vehicles, on the other hand can be quite expensive to deal with for such inspections. Additionally, there is now significant encouragement globally towards the deployment of more offshore renewable wind turbines and wave devices and the requirement for underwater inspection can be expected to increase significantly in the coming years. While the merit of image processing based assessment of the condition of underwater structures is understood to a certain degree, there is no existing protocol on such image based methods. This paper discusses and describes an image processing protocol for underwater inspection of structures. A stereo imaging image processing method is considered in this regard and protocols are suggested for image storage, imaging, diving, and inspection. A combined underwater imaging protocol is finally presented which can be used for a variety of situations within a range of image scenes and environmental conditions affecting the imaging conditions. An example of detecting marine growth is presented of a structure in Cork Harbour, Ireland.

Temporary implant-supported prosthesis for immediate loading according to a chair-side concept: technical note and results from 37 consecutive cases.

PubMed

Ostman, Pär-Olov; Hellman, Mats; Sennerby, Lars; Wennerberg, Ann

2008-05-01

During the last years, focus has been paid to implant treatment using immediate function protocols, and different approaches to provide patients with temporary constructions have been presented. Most of these techniques involve dental technicians producing the temporary construction, for example, rebuilding existing dentures, acrylic bridges, etc. The purpose of this prospective clinical study was to evaluate the clinical outcome of a chair-side technique of a cost-effective temporary prosthesis. Fixture survival rate and risk of temporary bridge failure were analyzed. Thirty-seven partially or totally edentate patients (18 female and 19 male; mean age: 66.7 years) treated with chair-side manufactured temporary restorations (QuickBridge, BIOMET 3i, Palm Beach, Fl, USA) for immediate loading have been evaluated. The prostheses extended from two unit bridges supported by two implants to full-arch construction supported by six implants. The temporary prostheses were monitored from the day of surgery and delivery to the time of replacement with a permanent prosthetic construction 3 to 6 months later. No implants were lost during the observation time. One (3%) temporary prosthesis fractured and additional two (6%) loosened during the follow-up time. The study indicated that the tested chair-side concept for manufacturing of temporary prosthesis for immediate loading of dental implants is a viable approach.

Assessing viability of extracorporeal preserved muscle transplants using external field stimulation: a novel tool to improve methods prolonging bridge-to-transplantation time

PubMed Central

Taeger, Christian D.; Friedrich, Oliver; Dragu, Adrian; Weigand, Annika; Hobe, Frieder; Drechsler, Caroline; Geppert, Carol I.; Arkudas, Andreas; Münch, Frank; Buchholz, Rainer; Pollmann, Charlotte; Schramm, Axel; Birkholz, Torsten; Horch, Raymund E.; Präbst, Konstantin

2015-01-01

Preventing ischemia-related cell damage is a priority when preserving tissue for transplantation. Perfusion protocols have been established for a variety of applications and proven to be superior to procedures used in clinical routine. Extracorporeal perfusion of muscle tissue though cumbersome is highly desirable since it is highly susceptible to ischemia-related damage. To show the efficacy of different perfusion protocols external field stimulation can be used to immediately visualize improvement or deterioration of the tissue during active and running perfusion protocols. This method has been used to show the superiority of extracorporeal perfusion using porcine rectus abdominis muscles perfused with heparinized saline solution. Perfused muscles showed statistically significant higher ability to exert force compared to nonperfused ones. These findings can be confirmed using Annexin V as marker for cell damage, perfusion of muscle tissue limits damage significantly compared to nonperfused tissue. The combination of extracorporeal perfusion and external field stimulation may improve organ conservation research. PMID:26145230

Interdisciplinary collaboration in the use of a music-with-movement intervention to promote the wellbeing of people with dementia and their families: Development of an evidence-based intervention protocol.

PubMed

Lai, Claudia K Y; Lai, Daniel L L; Ho, Jacqueline S C; Wong, Kitty K Y; Cheung, Daphne S K

2016-03-01

The music-with-movement intervention is particularly suitable for people with dementia because their gross motor ability is preserved until the later stage of dementia. This study examines the effect of music-with-movement on reducing anxiety, sleep disturbances, and improving the wellbeing of people with dementia. This paper reports the first stage of the study - developing the intervention protocol that staff can use to teach family caregivers. A registered music therapist developed a music-with-movement protocol and taught staff of two social service centers over five weekly 1.5 h sessions, with center-in-charges (social workers and occupational therapists) and our research team joining these sessions to provide comments from their professional perspective. Each discipline had different expectations about the content; therefore, numerous meetings and discussions were held to bridge these differences and fine-tune the protocol. Few healthcare professionals doubt the merits of interdisciplinary collaboration at all levels of health promotion. In practice, interdisciplinary collaboration is complex and requires commitment. Openness and persistence is required from all stakeholders to achieve a successful intervention for consumers. © 2015 Wiley Publishing Asia Pty Ltd.

Pointing System Simulation Toolbox with Application to a Balloon Mission Simulator

NASA Technical Reports Server (NTRS)

Maringolo Baldraco, Rosana M.; Aretskin-Hariton, Eliot D.; Swank, Aaron J.

2017-01-01

The development of attitude estimation and pointing-control algorithms is necessary in order to achieve high-fidelity modeling for a Balloon Mission Simulator (BMS). A pointing system simulation toolbox was developed to enable this. The toolbox consists of a star-tracker (ST) and Inertial Measurement Unit (IMU) signal generator, a UDP (User Datagram Protocol) communication le (bridge), and an indirect-multiplicative extended Kalman filter (imEKF). This document describes the Python toolbox developed and the results of its implementation in the imEKF.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Zhang, Jinshui; Qiao, Zhenan -An; Mahurin, Shannon Mark

A soft chemistry synthetic strategy based on a Friedel Crafts alkylation reaction is developed for the textural engineering of phenolic resin (PR) with a robust mesoporous framework to avoid serious framework shrinkage and maximize retention of organic functional moieties. By taking advantage of the structural benefits of molecular bridges, the resultant sample maintains a bimodal micro-mesoporous architecture with well-preserved organic functional groups, which is effective for carbon capture. Furthermore, this soft chemistry synthetic protocol can be further extended to nanotexture other aromatic-based polymers with robust frameworks.

Creating a Controlled Vocabulary for the Ethics of Human Research: Towards a Biomedical Ethics Ontology

PubMed Central

Koepsell, David; Arp, Robert; Fostel, Jennifer; Smith, Barry

2009-01-01

Ontologies describe reality in specific domains in ways that can bridge various disciplines and languages. They allow easier access and integration of information that is collected by different groups. Ontologies are currently used in the biomedical sciences, geography, and law. A Biomedical Ethics Ontology (BMEO) would benefit members of ethics committees who deal with protocols and consent forms spanning numerous fields of inquiry. There already exists the Ontology for Biomedical Investigations (OBI); the proposed BMEO would interoperate with OBI, creating a powerful information tool. We define a domain ontology and begin to construct a BMEO, focused on the process of evaluating human research protocols. Finally, we show how our BMEO can have practical applications for ethics committees. This paper describes ongoing research and a strategy for its broader continuation and cooperation. PMID:19374479

Preparation of Low-Input and Ligation-Free ChIP-seq Libraries Using Template-Switching Technology.

PubMed

Bolduc, Nathalie; Lehman, Alisa P; Farmer, Andrew

2016-10-10

Chromatin immunoprecipitation (ChIP) followed by high-throughput sequencing (ChIP-seq) has become the gold standard for mapping of transcription factors and histone modifications throughout the genome. However, for ChIP experiments involving few cells or targeting low-abundance transcription factors, the small amount of DNA recovered makes ligation of adapters very challenging. In this unit, we describe a ChIP-seq workflow that can be applied to small cell numbers, including a robust single-tube and ligation-free method for preparation of sequencing libraries from sub-nanogram amounts of ChIP DNA. An example ChIP protocol is first presented, resulting in selective enrichment of DNA-binding proteins and cross-linked DNA fragments immobilized on beads via an antibody bridge. This is followed by a protocol for fast and easy cross-linking reversal and DNA recovery. Finally, we describe a fast, ligation-free library preparation protocol, featuring DNA SMART technology, resulting in samples ready for Illumina sequencing. © 2016 by John Wiley & Sons, Inc. Copyright © 2016 John Wiley & Sons, Inc.

Determining Functional Aptamer-Protein Interaction by Biolayer Interferometry.

PubMed

Lou, Xinhui; Egli, Martin; Yang, Xianbin

2016-12-01

Short single-stranded nucleic acids called aptamers are widely being explored as recognition molecules of high affinity and specificity for binding a wide range of target molecules, particularly protein targets. In biolayer interferometry (BLI), a simple Dip-and-Read approach in which the aptamer-coated biosensors are dipped into microplate wells is used to study the interactions between an aptamer and its target protein. Here we describe the protocol for the analysis of the interaction between a well-characterized anti-thrombin RNA aptamer with thrombin (Basic Protocol). We also report on the protocol for the affinity screening of a panel of anti-thrombin RNA aptamers with a single phosphorodithioate (PS2) modification, whereby the position of the modification along the RNA backbone is varied systematically (Support Protocol). The PS2 modification uses two sulfur atoms to replace two non-bridging oxygen atoms at an internucleotide phosphodiester backbone linkage. The PS2-modified RNAs are nuclease resistant and several in vitro and in vivo assays have demonstrated their biological activity. For example, combining the PS2 with the 2'-OMe modification affords increased loading of modified small interfering RNA (siRNA) duplexes into the RNA-induced silencing complex (RISC) as well as enhanced gene-silencing antitumor activity. © 2016 by John Wiley & Sons, Inc. Copyright © 2016 John Wiley & Sons, Inc.

Dynamic federation of grid and cloud storage

NASA Astrophysics Data System (ADS)

Furano, Fabrizio; Keeble, Oliver; Field, Laurence

2016-09-01

The Dynamic Federations project ("Dynafed") enables the deployment of scalable, distributed storage systems composed of independent storage endpoints. While the Uniform Generic Redirector at the heart of the project is protocol-agnostic, we have focused our effort on HTTP-based protocols, including S3 and WebDAV. The system has been deployed on testbeds covering the majority of the ATLAS and LHCb data, and supports geography-aware replica selection. The work done exploits the federation potential of HTTP to build systems that offer uniform, scalable, catalogue-less access to the storage and metadata ensemble and the possibility of seamless integration of other compatible resources such as those from cloud providers. Dynafed can exploit the potential of the S3 delegation scheme, effectively federating on the fly any number of S3 buckets from different providers and applying a uniform authorization to them. This feature has been used to deploy in production the BOINC Data Bridge, which uses the Uniform Generic Redirector with S3 buckets to harmonize the BOINC authorization scheme with the Grid/X509. The Data Bridge has been deployed in production with good results. We believe that the features of a loosely coupled federation of open-protocolbased storage elements open many possibilities of smoothly evolving the current computing models and of supporting new scientific computing projects that rely on massive distribution of data and that would appreciate systems that can more easily be interfaced with commercial providers and can work natively with Web browsers and clients.

Interreality for the management and training of psychological stress: study protocol for a randomized controlled trial

PubMed Central

2013-01-01

Background Psychological stress occurs when an individual perceives that environmental demands tax or exceed his or her adaptive capacity. Its association with severe health and emotional diseases, points out the necessity to find new efficient strategies to treat it. Moreover, psychological stress is a very personal problem and requires training focused on the specific needs of individuals. To overcome the above limitations, the INTERSTRESS project suggests the adoption of a new paradigm for e-health - Interreality - that integrates contextualized assessment and treatment within a hybrid environment, bridging the physical and the virtual worlds. According to this premise, the aim of this study is to investigate the advantages of using advanced technologies, in combination with cognitive behavioral therapy (CBT), based on a protocol for reducing psychological stress. Methods/Design The study is designed as a randomized controlled trial. It includes three groups of approximately 50 subjects each who suffer from psychological stress: (1) the experimental group, (2) the control group, (3) the waiting list group. Participants included in the experimental group will receive a treatment based on cognitive behavioral techniques combined with virtual reality, biofeedback and mobile phone, while the control group will receive traditional stress management CBT-based training, without the use of new technologies. The wait-list group will be reassessed and compared with the two other groups five weeks after the initial evaluation. After the reassessment, the wait-list patients will randomly receive one of the two other treatments. Psychometric and physiological outcomes will serve as quantitative dependent variables, while subjective reports of participants will be used as the qualitative dependent variable. Discussion What we would like to show with the present trial is that bridging virtual experiences, used to learn coping skills and emotional regulation, with real experiences using advanced technologies (virtual reality, advanced sensors and smartphones) is a feasible way to address actual limitations of existing protocols for psychological stress. Trial registration http://clinicaltrials.gov/ct2/show/NCT01683617 PMID:23806013

Can a science-based definition of acupuncture improve clinical outcomes?

PubMed

Priebe, Ted; Stumpf, Steven H; Zalunardo, Rod

2017-05-01

Research on acupuncture has been muddled by attempts to bridge the ancient with the modern. Barriers to effectiveness research are reflected in recurring conflicts that include disagreement on use of the most basic terms, lack of standard intervention controls, and the absence of functional measures for assessing treatment effect. Acupuncture research has stalled at the "placebo barrier" wherein acupuncture is "no better than placebo." The most widely recognized comparative effectiveness research in acupuncture does not compare acupuncture treatment protocols within groups, thereby, mutating large scale effectiveness studies into large scale efficacy trials. Too often research in acupuncture attempts to tie outcomes to traditional belief systems thereby limiting usefulness of the research. The acupuncture research paradigm needs to focus more closely on a scientific definition of treatments and outcomes that compare protocols in terms of prevalent clinical issues such as relative effectiveness for treating pain.

The evolution of sex differences in mate searching when females benefit: new theory and a comparative test.

PubMed

McCartney, J; Kokko, H; Heller, K-G; Gwynne, D T

2012-03-22

Sexual selection is thought to have led to searching as a profitable, but risky way of males obtaining mates. While there is great variation in which sex searches, previous theory has not considered search evolution when both males and females benefit from multiple mating. We present new theory and link it with data to bridge this gap. Two different search protocols exist between species in the bush-cricket genus Poecilimon (Orthoptera): females search for calling males, or males search for calling females. Poecilimon males also transfer a costly nuptial food gift to their mates during mating. We relate variations in searching protocols to variation in nuptial gift size among 32 Poecilimon taxa. As predicted, taxa where females search produce significantly larger nuptial gifts than those where males search. Our model and results show that search roles can reverse when multiple mating brings about sufficiently strong material benefits to females.

Stochastic Thermodynamics of a Particle in a Box.

PubMed

Gong, Zongping; Lan, Yueheng; Quan, H T

2016-10-28

The piston system (particles in a box) is the simplest paradigmatic model in traditional thermodynamics. However, the recently established framework of stochastic thermodynamics (ST) fails to apply to this model system due to the embedded singularity in the potential. In this Letter, we study the ST of a particle in a box by adopting a novel coordinate transformation technique. Through comparing with the exact solution of a breathing harmonic oscillator, we obtain analytical results of work distribution for an arbitrary protocol in the linear response regime and verify various predictions of the fluctuation-dissipation relation. When applying to the Brownian Szilard engine model, we obtain the optimal protocol λ_{t}=λ_{0}2^{t/τ} for a given sufficiently long total time τ. Our study not only establishes a paradigm for studying ST of a particle in a box but also bridges the long-standing gap in the development of ST.

A PCIe Gen3 based readout for the LHCb upgrade

NASA Astrophysics Data System (ADS)

Bellato, M.; Collazuol, G.; D'Antone, I.; Durante, P.; Galli, D.; Jost, B.; Lax, I.; Liu, G.; Marconi, U.; Neufeld, N.; Schwemmer, R.; Vagnoni, V.

2014-06-01

The architecture of the data acquisition system foreseen for the LHCb upgrade, to be installed by 2018, is devised to readout events trigger-less, synchronously with the LHC bunch crossing rate at 40 MHz. Within this approach the readout boards act as a bridge between the front-end electronics and the High Level Trigger (HLT) computing farm. The baseline design for the LHCb readout is an ATCA board requiring dedicated crates. A local area standard network protocol is implemented in the on-board FPGAs to read out the data. The alternative solution proposed here consists in building the readout boards as PCIe peripherals of the event-builder servers. The main architectural advantage is that protocol and link-technology of the event-builder can be left open until very late, to profit from the most cost-effective industry technology available at the time of the LHC LS2.

The Roles of Pharmacy Schools in Bridging the Gap Between Law and Practice.

PubMed

Adams, Alex J; Dering-Anderson, Allison; Klepser, Michael E; Klepser, Donald

2018-05-01

Progressive pharmacy laws do not always lead to progressive pharmacy practice. Progressive laws are necessary, but not sufficient for pharmacy services to take off in practice. Pharmacy schools can play critical roles by working collaboratively with community pharmacies to close the gap between law and practice. Our experiences launching pharmacy-based point-of-care testing services in community pharmacy settings illustrate some of the roles schools can play, including: developing and providing standardized training, developing template protocols, providing workflow support, sparking collaboration across pharmacies, providing policy support, and conducting research.

Hypercrosslinked phenolic polymers with well developed mesoporous frameworks

DOE PAGES

Zhang, Jinshui; Qiao, Zhenan -An; Mahurin, Shannon Mark; ...

2015-02-12

A soft chemistry synthetic strategy based on a Friedel Crafts alkylation reaction is developed for the textural engineering of phenolic resin (PR) with a robust mesoporous framework to avoid serious framework shrinkage and maximize retention of organic functional moieties. By taking advantage of the structural benefits of molecular bridges, the resultant sample maintains a bimodal micro-mesoporous architecture with well-preserved organic functional groups, which is effective for carbon capture. Furthermore, this soft chemistry synthetic protocol can be further extended to nanotexture other aromatic-based polymers with robust frameworks.

The free energy of locking a ring: Changing a deoxyribonucleoside to a locked nucleic acid.

PubMed

Xu, You; Villa, Alessandra; Nilsson, Lennart

2017-06-05

Locked nucleic acid (LNA), a modified nucleoside which contains a bridging group across the ribose ring, improves the stability of DNA/RNA duplexes significantly, and therefore is of interest in biotechnology and gene therapy applications. In this study, we investigate the free energy change between LNA and DNA nucleosides. The transformation requires the breaking of the bridging group across the ribose ring, a problematic transformation in free energy calculations. To address this, we have developed a 3-step (easy to implement) and a 1-step protocol (more efficient, but more complicated to setup), for single and dual topologies in classical molecular dynamics simulations, using the Bennett Acceptance Ratio method to calculate the free energy. We validate the approach on the solvation free energy difference for the nucleosides thymidine, cytosine, and 5-methyl-cytosine. © 2017 The Authors. Journal of Computational Chemistry Published by Wiley Periodicals, Inc. © 2017 The Authors. Journal of Computational Chemistry Published by Wiley Periodicals, Inc.

Kinetics of force recovery following length changes in active skinned single fibres from rabbit psoas muscle

PubMed Central

Burton, Kevin; Simmons, Robert M; Sleep, John; Smith, David A

2006-01-01

Redevelopment of isometric force following shortening of skeletal muscle is thought to result from a redistribution of cross-bridge states. We varied the initial force and cross-bridge distribution by applying various length-change protocols to active skinned single fibres from rabbit psoas muscle, and observed the effect on the slowest phase of recovery (‘late recovery’) that follows transient changes. In response to step releases that reduced force to near zero (∼8 nm (half sarcomere)−1) or prolonged shortening at high velocity, late recovery was well described by two exponentials of approximately equal amplitude and rate constants of ∼2 s−1 and ∼9 s−1 at 5°C. When a large restretch was applied at the end of rapid shortening, recovery was accelerated by (1) the introduction of a slow falling component that truncated the rise in force, and (2) a relative increase in the contribution of the fast exponential component. The rate of the slow fall was similar to that observed after a small isometric step stretch, with a rate of 0.4–0.8 s−1, and its effects could be reversed by reducing force to near zero immediately after the stretch. Force at the start of late recovery was varied in a series of shortening steps or ramps in order to probe the effect of cross-bridge strain on force redevelopment. The rate constants of the two components fell by 40–50% as initial force was raised to 75–80% of steady isometric force. As initial force increased, the relative contribution of the fast component decreased, and this was associated with a length constant of about 2 nm. The results are consistent with a two-state strain-dependent cross-bridge model. In the model there is a continuous distribution of recovery rate constants, but two-exponential fits show that the fast component results from cross-bridges initially at moderate positive strain and the slow component from cross-bridges at high positive strain. PMID:16497718

Introducing Clicker Training as a Cognitive Enrichment for Laboratory Mice.

PubMed

Leidinger, Charlotte; Herrmann, Felix; Thöne-Reineke, Christa; Baumgart, Nadine; Baumgart, Jan

2017-03-06

Establishing new refinement strategies in laboratory animal science is a central goal in fulfilling the requirements of Directive 2010/63/EU. Previous research determined a profound impact of gentle handling protocols on the well-being of laboratory mice. By introducing clicker training to the keeping of mice, not only do we promote the amicable treatment of mice, but we also enable them to experience cognitive enrichment. Clicker training is a form of positive reinforcement training using a conditioned secondary reinforcer, the "click" sound of a clicker, which serves as a time bridge between the strengthened behavior and an upcoming reward. The effective implementation of the clicker training protocol with a cohort of 12 BALB/c inbred mice of each sex proved to be uncomplicated. The mice learned rather quickly when challenged with tasks of the clicker training protocol, and almost all trained mice overcame the challenges they were given (100% of female mice and 83% of male mice). This study has identified that clicker training for mice strongly correlates with reduced fear in the mice during human-mice interactions, as shown by reduced anxiety-related behaviors (e.g., defecation, vocalization, and urination) and fewer depression-like behaviors (e.g., floating). By developing a reliable protocol that can be easily integrated into the daily routine of the keeping of laboratory mice, the lifetime experience of welfare in the mice can be improved substantially.

Trustworthiness of detectors in quantum key distribution with untrusted detectors

DOE PAGES

Qi, Bing

2015-02-25

Measurement-device-independent quantum key distribution (MDI-QKD) protocol has been demonstrated as a viable solution to detector side-channel attacks. One of the main advantages of MDI-QKD is that the security can be proved without making any assumptions about how the measurement device works. The price to pay is the relatively low secure key rate comparing with conventional quantum key distribution (QKD), such as the decoy-state BB84 protocol. Recently a new QKD protocol, aiming at bridging the strong security of MDI-QKD with the high e ciency of conventional QKD, has been proposed. In this protocol, the legitimate receiver employs a trusted linear opticsmore » network to encode information on photons received from an insecure quantum channel, and then performs a Bell state measurement (BSM) using untrusted detectors. One crucial assumption made in most of these studies is that the untrusted BSM located inside the receiver's laboratory cannot send any unwanted information to the outside. Here in this paper, we show that if the BSM is completely untrusted, a simple scheme would allow the BSM to send information to the outside. Combined with Trojan horse attacks, this scheme could allow Eve to gain information of the quantum key without being detected. Ultimately, to prevent the above attack, either countermeasures to Trojan horse attacks or some trustworthiness to the "untrusted" BSM device is required.« less

Hybrid networking sensing system for structural health monitoring of a concrete cable-stayed bridge

NASA Astrophysics Data System (ADS)

Torbol, Marco; Kim, Sehwan; Chien, Ting-Chou; Shinozuka, Masanobu

2013-04-01

The purpose of this study is the remote structural health monitoring to identify the torsional natural frequencies and mode shapes of a concrete cable-stayed bridge using a hybrid networking sensing system. The system consists of one data aggregation unit, which is daisy-chained to one or more sensing nodes. A wireless interface is used between the data aggregation units, whereas a wired interface is used between a data aggregation unit and the sensing nodes. Each sensing node is equipped with high-precision MEMS accelerometers with adjustable sampling frequency from 0.2 Hz to 1.2 kHz. The entire system was installed inside the reinforced concrete box-girder deck of Hwamyung Bridge, which is a cable stayed bridge in Busan, South Korea, to protect the system from the harsh environmental conditions. This deployment makes wireless communication a challenge due to the signal losses and the high levels of attenuation. To address these issues, the concept of hybrid networking system is introduced with the efficient local power distribution technique. The theoretical communication range of Wi-Fi is 100m. However, inside the concrete girder, the peer to peer wireless communication cannot exceed about 20m. The distance is further reduced by the line of sight between the antennas. However, the wired daisy-chained connection between sensing nodes is useful because the data aggregation unit can be placed in the optimal location for transmission. To overcome the limitation of the wireless communication range, we adopt a high-gain antenna that extends the wireless communication distance to 50m. Additional help is given by the multi-hopping data communication protocol. The 4G modem, which allows remote access to the system, is the only component exposed to the external environment.

Holocene development of the eastern Gulf of Finland coastal zone (Baltic Sea)

NASA Astrophysics Data System (ADS)

Ryabchuk, Daria; Sergeev, Alexander; Gusentsova, Tatiana; Gerasimov, Dmitry; Zhamoida, Vladimir; Amantov, Aleksey; Kulkova, Marianna; Sorokin, Peter

2014-05-01

In 2011-2013 geoarcheological and marine geological research of the eastern Gulf of Finland coasts and near-shore bottom were undertaken. Researches were concentrated within several key-areas (Sestroretskaya Lowland, Narva-Luga Klint Bay and southern coastal zone of the Gulf (near Bolshaya Izhora village). Study areas can provide important information about Gulf of Finland Holocene coastal development as since Ancylus time (about 10000 cal.BP). Development of numerous sand accretion forms (spits, bars, dunes) of different shape, age and genesis caused formation of lagoon systems, situated now on-land due to land uplift. Coasts of lagoons in Sestroretskaya Lowland and Narva-Luga Klint Bay were inhabited by Neolithic and Early Metal people. Analysis of coastal morphology and results of geological research (GIS relief analyses, ground penetrating radar, drilling, grain-size analyses, radiocarbon dating) and geoarcheological studies allowed to reconstruct the mechanism of large accretion bodies (bars and spits) and lagoon systems formation during last 8000 years. Geoarcheological studies carried out within eastern Gulf of Finland coasts permitted to find some features of the Neolithic - Early Metal settlements distribution. Another important features of the eastern Gulf of Finland coastal zone relief are the series of submarine terraces found in the Gulf bottom (sea water depths 10 to 2 m). Analyses of the submarine terraces morphology and geology (e.g. grain-size distribution, pollen analyses and organic matter dating) allow to suppose that several times during Holocene (including preAncylus (11000 cal.BP) and preLittorina (8500 cal.BP) regressions) the sea-water level was lower than nowadays. During the maximal stage of the Littorina transgression (7600-7200 cal. BP) several open bays connected with the Littorina Sea appeared in this area. The lagoon systems and sand accretion bodies (spits and bars) were formed during the following decreasing of the sea level. Late Neolithic-Early Metal Epoch archaeological contexts of the end of the 6th to the beginning of the 5th ka BP mark the rate of regression. The results of geological research of submarine terraces and modeling show that by the time period about 3000 cal. BP, relative water level decreased (in the vicinities of Sestroretskaya Lowland and Bolshaya Izhora village by modern depth of about 3 m). The main trend of the final stage of paleogeographical development was the gradual relative sea-level rise up to the modern shoreline. Studies are supported by Russian Foundation for Basic Research (projects 12-05-01121 and 12-05-31196).

Rhodium-catalyzed asymmetric tandem cyclization for efficient and rapid access to underexplored heterocyclic tertiary allylic alcohols containing a tetrasubstituted olefin.

PubMed

Li, Yi; Xu, Ming-Hua

2014-05-16

The first Rh-catalyzed asymmetric tandem cyclization of nitrogen- or oxygen-bridged 5-alkynones with arylboronic acids was achieved. The simple catalytic system involving a rhodium(I) complex with readily available chiral BINAP ligand promotes the reaction to proceed in a highly stereocontrolled manner. This protocol provides a very reliable and practical access to a variety of chiral heterocyclic tertiary allylic alcohols possessing a tetrasubstituted carbon stereocenter and an all-carbon tetrasubstituted olefin functionality in good yields with great enantioselectivities up to 99% ee.

Optimal control of complex atomic quantum systems

PubMed Central

van Frank, S.; Bonneau, M.; Schmiedmayer, J.; Hild, S.; Gross, C.; Cheneau, M.; Bloch, I.; Pichler, T.; Negretti, A.; Calarco, T.; Montangero, S.

2016-01-01

Quantum technologies will ultimately require manipulating many-body quantum systems with high precision. Cold atom experiments represent a stepping stone in that direction: a high degree of control has been achieved on systems of increasing complexity. However, this control is still sub-optimal. In many scenarios, achieving a fast transformation is crucial to fight against decoherence and imperfection effects. Optimal control theory is believed to be the ideal candidate to bridge the gap between early stage proof-of-principle demonstrations and experimental protocols suitable for practical applications. Indeed, it can engineer protocols at the quantum speed limit – the fastest achievable timescale of the transformation. Here, we demonstrate such potential by computing theoretically and verifying experimentally the optimal transformations in two very different interacting systems: the coherent manipulation of motional states of an atomic Bose-Einstein condensate and the crossing of a quantum phase transition in small systems of cold atoms in optical lattices. We also show that such processes are robust with respect to perturbations, including temperature and atom number fluctuations. PMID:27725688

Optimal control of complex atomic quantum systems.

PubMed

van Frank, S; Bonneau, M; Schmiedmayer, J; Hild, S; Gross, C; Cheneau, M; Bloch, I; Pichler, T; Negretti, A; Calarco, T; Montangero, S

2016-10-11

Quantum technologies will ultimately require manipulating many-body quantum systems with high precision. Cold atom experiments represent a stepping stone in that direction: a high degree of control has been achieved on systems of increasing complexity. However, this control is still sub-optimal. In many scenarios, achieving a fast transformation is crucial to fight against decoherence and imperfection effects. Optimal control theory is believed to be the ideal candidate to bridge the gap between early stage proof-of-principle demonstrations and experimental protocols suitable for practical applications. Indeed, it can engineer protocols at the quantum speed limit - the fastest achievable timescale of the transformation. Here, we demonstrate such potential by computing theoretically and verifying experimentally the optimal transformations in two very different interacting systems: the coherent manipulation of motional states of an atomic Bose-Einstein condensate and the crossing of a quantum phase transition in small systems of cold atoms in optical lattices. We also show that such processes are robust with respect to perturbations, including temperature and atom number fluctuations.

Integration of the Chinese HPC Grid in ATLAS Distributed Computing

NASA Astrophysics Data System (ADS)

Filipčič, A.; ATLAS Collaboration

2017-10-01

Fifteen Chinese High-Performance Computing sites, many of them on the TOP500 list of most powerful supercomputers, are integrated into a common infrastructure providing coherent access to a user through an interface based on a RESTful interface called SCEAPI. These resources have been integrated into the ATLAS Grid production system using a bridge between ATLAS and SCEAPI which translates the authorization and job submission protocols between the two environments. The ARC Computing Element (ARC-CE) forms the bridge using an extended batch system interface to allow job submission to SCEAPI. The ARC-CE was setup at the Institute for High Energy Physics, Beijing, in order to be as close as possible to the SCEAPI front-end interface at the Computing Network Information Center, also in Beijing. This paper describes the technical details of the integration between ARC-CE and SCEAPI and presents results so far with two supercomputer centers, Tianhe-IA and ERA. These two centers have been the pilots for ATLAS Monte Carlo Simulation in SCEAPI and have been providing CPU power since fall 2015.

Development of an intelligent hydroinformatic system for real-time monitoring and assessment of civil infrastructure

NASA Astrophysics Data System (ADS)

Cahill, Paul; Michalis, Panagiotis; Solman, Hrvoje; Kerin, Igor; Bekic, Damir; Pakrashi, Vikram; McKeogh, Eamon

2017-04-01

With the effects of climate change becoming more apparent, extreme weather events are now occurring with greater frequency throughout the world. Such extreme events have resulted in increased high intensity flood events which are having devastating consequences on hydro-structures, especially on bridge infrastructure. The remote and often inaccessible nature of such bridges makes inspections problematic, a major concern if safety assessments are required during and after extreme flood events. A solution to this is the introduction of smart, low cost sensing solutions at locations susceptible to hydro-hazards. Such solutions can provide real-time information on the health of the bridge and its environments, with such information aiding in the mitigation of the risks associated with extreme weather events. This study presents the development of an intelligent system for remote, real-time monitoring of hydro-hazards to bridge infrastructure. The solution consists of two types of remote monitoring stations which have the capacity to monitor environmental conditions and provide real-time information to a centralized, big data database solution, from which an intelligent decision support system will accommodate the results to control and manage bridge, river and catchment assets. The first device developed as part of the system is the Weather Information Logging Device (WILD), which monitors rainfall, temperature and air and soil moisture content. The ability of the WILD to monitor rainfall in real time enables flood early warning alerts and predictive river flow conditions, thereby enabling decision makers the ability to make timely and effective decisions about critical infrastructures in advance of extreme flood events. The WILD is complemented by a second monitoring device, the Bridge Information Recording Device (BIRD), which monitors water levels at a given location in real-time. The monitoring of water levels of a river allows for, among other applications, hydraulic modelling to assess the likely impact that severe flood events will have on a bridges foundation, particularly due to scour. The process of reading and validating data from the WILD and BIRD buffer servers is outlined, as is the transmission protocol used for the sending of recorded data to a centralized repository for further use and analysis. Finally, the development of a centralized repository for the collection of data from the WILD and BIRD devices is presented. Eventually the big data solution would be used to receive, store and send the monitored data to the hydrological models, whether existing or developed, and the results would be transmitted to the intelligent decision support system based on a web-based platform, for managing, planning and executing data, processes and procedures for bridge assets. The development of intelligent hydroinformatic system is an important tool for the protection of key infrastructure assets from the increasingly common effects of climate change. Acknowledgement The authors wish to acknowledge the financial support of the European Commission, through the Marie Curie Industry-Academia Partnership and Pathways Network BRIDGE SMS (Intelligent Bridge Assessment Maintenance and Management System) - FP7-People-2013-IAPP- 612517.

Cool Apps: Building Cryospheric Data Applications With Standards-Based Service Oriented Architecture

NASA Astrophysics Data System (ADS)

Collins, J. A.; Truslove, I.; Billingsley, B. W.; Oldenburg, J.; Brodzik, M.; Lewis, S.; Liu, M.

2012-12-01

The National Snow and Ice Data Center (NSIDC) holds a large collection of cryospheric data, and is involved in a number of informatics research and development projects aimed at improving the discoverability and accessibility of these data. To develop high-quality software in a timely manner, we have adopted a Service-Oriented Architecture (SOA) approach for our core technical infrastructure development. Data services at NSIDC are internally exposed to other tools and applications through standards-based service interfaces. These standards include OAI-PMH (Open Archives Initiative Protocol for Metadata Harvesting), various OGC (Open Geospatial Consortium) standards including WMS (Web Map Service) and WFS (Web Feature Service), ESIP (Federation of Earth Sciences Information Partners) OpenSearch, and NSIDC-specific RESTful services. By taking a standards-based approach, we are able to use off-the-shelf tools and libraries to consume, translate and broker these data services, and thus develop applications faster. Additionally, by exposing public interfaces to these services we provide valuable data services to technical collaborators; for example, NASA Reverb (http://reverb.echo.nasa.gov) uses NSIDC's WMS services. Our latest generation of web applications consume these data services directly. The most complete example of this is the Operation IceBridge Data Portal (http://nsidc.org/icebridge/portal) which depends on many of the aforementioned services, and clearly exhibits many of the advantages of building applications atop a service-oriented architecture. This presentation outlines the architectural approach and components and open standards and protocols adopted at NSIDC, demonstrates the interactions and uses of public and internal service interfaces currently powering applications including the IceBridge Data Portal, and outlines the benefits and challenges of this approach.

A surgical protocol of ankle arthrodesis with combined Ilizarov's distraction-compression osteogenesis and locked nailing for osteomyelitis around the ankle joint.

PubMed

Chen, Chuan-Mu; Su, Alvin W; Chiu, Fang-Yao; Chen, Tain-Hsiung

2010-09-01

Managing refractory osteomyelitis around the ankle joint has been challenging. Destruction of both the ankle and the subtalar joints was common in cases of open fracture. For those who already had multiple surgeries, it would be tough to salvage the limb. Our goal was to set up a staged surgical protocol aiming in treating the aforementioned clinical issue. Twelve male patients underwent our protocol since year 2000. All patients presented refractory osteomyelitis, ankle and subtalar joint destruction, and poor soft tissue condition. All cases had internal fixation for open fractures followed by multiple debridement surgery before. The mean age was 50.8 years (range, 37-71 years), and the median follow-up time was 61 months (range, 48-96 months). The surgical protocol consisted of radical debridement, distraction osteogenesis for segmental bone transport, and tibia lengthening to avoid leg length discrepancy followed by intramedullary nailing for tibio-talo-calcaneal arthrodesis. The external fixation period averaged 24.7 weeks (range, 12-36 weeks). The mean duration to solid union of the arthrodesis and the bridging callus was 18.3 weeks (range, 16-20 weeks). Mild surgical site infection occurred in four cases but all subsided after removal of the nail and oral antibiotics use. At latest follow-up, all patients were infection free and could walk with plantigrade feet. The mean American Orthopaedic Foot and Ankle Society hindfoot score rising from 21.5 points (range 20-24 points) preoperatively to 65.5 points (range, 60-72). This study has shown our staged surgical protocol may be effective in solving complicated osteomyelitis around the ankle, although salvaging the limb with successful ankle arthrodesis and minimized limb length inequality, yet improving the patients' ambulation level.

Stent deployment protocol for optimized real-time visualization during endovascular neurosurgery.

PubMed

Silva, Michael A; See, Alfred P; Dasenbrock, Hormuzdiyar H; Ashour, Ramsey; Khandelwal, Priyank; Patel, Nirav J; Frerichs, Kai U; Aziz-Sultan, Mohammad A

2017-05-01

Successful application of endovascular neurosurgery depends on high-quality imaging to define the pathology and the devices as they are being deployed. This is especially challenging in the treatment of complex cases, particularly in proximity to the skull base or in patients who have undergone prior endovascular treatment. The authors sought to optimize real-time image guidance using a simple algorithm that can be applied to any existing fluoroscopy system. Exposure management (exposure level, pulse management) and image post-processing parameters (edge enhancement) were modified from traditional fluoroscopy to improve visualization of device position and material density during deployment. Examples include the deployment of coils in small aneurysms, coils in giant aneurysms, the Pipeline embolization device (PED), the Woven EndoBridge (WEB) device, and carotid artery stents. The authors report on the development of the protocol and their experience using representative cases. The stent deployment protocol is an image capture and post-processing algorithm that can be applied to existing fluoroscopy systems to improve real-time visualization of device deployment without hardware modifications. Improved image guidance facilitates aneurysm coil packing and proper positioning and deployment of carotid artery stents, flow diverters, and the WEB device, especially in the context of complex anatomy and an obscured field of view.

Mapping 3D genome architecture through in situ DNase Hi-C.

PubMed

Ramani, Vijay; Cusanovich, Darren A; Hause, Ronald J; Ma, Wenxiu; Qiu, Ruolan; Deng, Xinxian; Blau, C Anthony; Disteche, Christine M; Noble, William S; Shendure, Jay; Duan, Zhijun

2016-11-01

With the advent of massively parallel sequencing, considerable work has gone into adapting chromosome conformation capture (3C) techniques to study chromosomal architecture at a genome-wide scale. We recently demonstrated that the inactive murine X chromosome adopts a bipartite structure using a novel 3C protocol, termed in situ DNase Hi-C. Like traditional Hi-C protocols, in situ DNase Hi-C requires that chromatin be chemically cross-linked, digested, end-repaired, and proximity-ligated with a biotinylated bridge adaptor. The resulting ligation products are optionally sheared, affinity-purified via streptavidin bead immobilization, and subjected to traditional next-generation library preparation for Illumina paired-end sequencing. Importantly, in situ DNase Hi-C obviates the dependence on a restriction enzyme to digest chromatin, instead relying on the endonuclease DNase I. Libraries generated by in situ DNase Hi-C have a higher effective resolution than traditional Hi-C libraries, which makes them valuable in cases in which high sequencing depth is allowed for, or when hybrid capture technologies are expected to be used. The protocol described here, which involves ∼4 d of bench work, is optimized for the study of mammalian cells, but it can be broadly applicable to any cell or tissue of interest, given experimental parameter optimization.

Heat and mass transfer during the cryopreservation of a bioartificial liver device: a computational model.

PubMed

Balasubramanian, Saravana K; Coger, Robin N

2005-01-01

Bioartificial liver devices (BALs) have proven to be an effective bridge to transplantation for cases of acute liver failure. Enabling the long-term storage of these devices using a method such as cryopreservation will ensure their easy off the shelf availability. To date, cryopreservation of liver cells has been attempted for both single cells and sandwich cultures. This study presents the potential of using computational modeling to help develop a cryopreservation protocol for storing the three dimensional BAL: Hepatassist. The focus is upon determining the thermal and concentration profiles as the BAL is cooled from 37 degrees C-100 degrees C, and is completed in two steps: a cryoprotectant loading step and a phase change step. The results indicate that, for the loading step, mass transfer controls the duration of the protocol, whereas for the phase change step, when mass transfer is assumed negligible, the latent heat released during freezing is the control factor. The cryoprotocol that is ultimately proposed considers time, cooling rate, and the temperature gradients that the cellular space is exposed to during cooling. To our knowledge, this study is the first reported effort toward designing an effective protocol for the cryopreservation of a three-dimensional BAL device.

Translating new knowledge into practices: reconceptualising stroke as an emergency condition

PubMed Central

Snow, Stephanie J

2013-01-01

Objectives To examine how the new concept of stroke as an emergency condition led to the development of new clinical pathways for stroke patients in Newcastle Upon Tyne, implemented through protocols which were then rapidly adopted across the UK and further afield. Methods Historical analysis using health policy documents, published papers and correspondence on stroke alongside 17 interviews with stroke clinicians and managers in the UK and the US. Results The challenges of implementation stemmed from organisational and professional barriers rather than scientific or technological difficulties. Stroke’s historical status as a non-treatable illness was a barrier to the adoption of acute treatments. Building new pathways for stroke patients by developing protocols for paramedics and emergency room staff originated as a local solution to a local problem but were taken up widely. Discussion Understanding the clinical response to the reconceptualisation of stroke as a treatable disease contributes to our understandings of the relations between clinical research and practice. These findings have implications for how we understand the translation of new knowledge into practice and its transfer across different clinical communities and settings. Protocols are shown to be a particularly valuable tool, bridging knowledge between communities and manifesting a new identity for stroke. PMID:23129788

Bridging psychological barriers between the child and the father after his returning from the war: Could group art therapy help?

PubMed

Mandić-Gajić, Gordana

2016-07-01

War veterans with chronic post-traumatic stress disorder (PTSD) have poorer family and parenting functioning, but little research has focused on these impairments. This paper presented how the series of drawings and the group art therapy process enhanced bridging the psychological barriers of a 33-year-old male PTSD war veteran to engagement with the child. After two years of deployment he returned home and suffered mostly from PTSD numbness and avoidance symptoms. The veteran had the family readjustment difficulties and felt guilty for being detached from his 3-year-old son. He under-went integrative treatment in the Day Unit Program. The drawings series were made by free associations. Clinical observations and group discussions were recorded in the group art therapy protocols. The presented patient got gratifications and support from the group members for his illustration of popular cartoon heroes, and decided to draw Mickey Mouse at home. On the next session he shared his satisfaction for bridging the gap between him and his son, having done the same drawings with his son at home. Beck's depression inventory (BDI) was used for self-rating of depression and a reduction of BDI score from 18 to 6 during the treatment course was recorded. Series of drawings illustrated shift from war related past toward current family life of the war veteran. Group art therapy gave him gratification and support with hope and a sense of belonging, thus facilitated his parenting readjustment.

Using Semantic Web technologies for the generation of domain-specific templates to support clinical study metadata standards.

PubMed

Jiang, Guoqian; Evans, Julie; Endle, Cory M; Solbrig, Harold R; Chute, Christopher G

2016-01-01

The Biomedical Research Integrated Domain Group (BRIDG) model is a formal domain analysis model for protocol-driven biomedical research, and serves as a semantic foundation for application and message development in the standards developing organizations (SDOs). The increasing sophistication and complexity of the BRIDG model requires new approaches to the management and utilization of the underlying semantics to harmonize domain-specific standards. The objective of this study is to develop and evaluate a Semantic Web-based approach that integrates the BRIDG model with ISO 21090 data types to generate domain-specific templates to support clinical study metadata standards development. We developed a template generation and visualization system based on an open source Resource Description Framework (RDF) store backend, a SmartGWT-based web user interface, and a "mind map" based tool for the visualization of generated domain-specific templates. We also developed a RESTful Web Service informed by the Clinical Information Modeling Initiative (CIMI) reference model for access to the generated domain-specific templates. A preliminary usability study is performed and all reviewers (n = 3) had very positive responses for the evaluation questions in terms of the usability and the capability of meeting the system requirements (with the average score of 4.6). Semantic Web technologies provide a scalable infrastructure and have great potential to enable computable semantic interoperability of models in the intersection of health care and clinical research.

Radio Hazard Safety Assessment for Marine Ship Transmitters: Measurements Using a New Data Collection Method and Comparison with ICNIRP and ARPANSA Limits

PubMed Central

Halgamuge, Malka N.

2015-01-01

We investigated the levels of radio frequency electromagnetic fields (RF EMFs) emitted from marine ship transmitters. In this study, we recorded the radio frequency (RF) electric field (EF) levels emitted from transmitters from a marine vessel focusing on the areas normally occupied by crew members and passengers. Previous studies considered radiation hazard safety assessment for marine vessels with a limited number of transmitters, such as very high-frequency (VHF) transceivers, radar and communication transmitters. In our investigation, EF levels from seven radio transmitters were measured, including: VHF, medium frequency/high frequency (MF/HF), satellite communication (Sat-Com C), AISnavigation, radar X-band and radar S-band. Measurements were carried out in a 40 m-long, three-level ship (upper deck, bridge deck and bridge roof) at 12 different locations. We developed a new data-collection protocol and performed it under 11 different scenarios to observe and measure the radiation emissions from all of the transmitters. In total, 528 EF field measurements were collected and averaged over all three levels of the marine ship with RF transmitters: the measured electric fields were the lowest on the upper deck (0.82–0.86 V/m), the highest on the bridge roof (2.15–3.70 V/m) and in between on the bridge deck (0.47–1.15 V/m). The measured EF levels were then assessed for compliance with the occupational and general public reference levels of the International Commission on Non-Ionizing Radiation Protection (ICNIRP) guidelines and the Australian Radiation Protection and Nuclear Safety Agency (ARPANSA) standards. The ICNIRP and the ARPANSA limits for the general public were exceeded on the bridge roof; nevertheless, the occupational limits were respected everywhere. The measured EF levels, hence, complied with the ICNIRP guidelines and the ARPANSA standards. In this paper, we provide a new data collection model for future surveys, which could be conducted with larger samples to verify our observations. Furthermore, this new method could be useful as a reference for researchers and industry professionals without direct access to the necessary equipment. PMID:25996887

Initial Characterization of Optical Communications with Disruption-Tolerant Network Protocols

NASA Technical Reports Server (NTRS)

Schoolcraft, Joshua; Wilson, Keith

2011-01-01

Disruption-tolerant networks (DTNs) are groups of network assets connected with a suite of communication protocol technologies designed to mitigate the effects of link delay and disruption. Application of DTN protocols to diverse groups of network resources in multiple sub-networks results in an overlay network-of-networks with autonomous data routing capability. In space environments where delay or disruption is expected, performance of this type of architecture (such as an interplanetary internet) can increase with the inclusion of new communications mediums and techniques. Space-based optical communication links are therefore an excellent building block of space DTN architectures. When compared to traditional radio frequency (RF) communications, optical systems can provide extremely power-efficient and high bandwidth links bridging sub-networks. Because optical links are more susceptible to link disruption and experience the same light-speed delays as RF, optical-enabled DTN architectures can lessen potential drawbacks and maintain the benefits of autonomous optical communications over deep space distances. These environment-driven expectations - link delay and interruption, along with asymmetric data rates - are the purpose of the proof-of-concept experiment outlined herein. In recognizing the potential of these two technologies, we report an initial experiment and characterization of the performance of a DTN-enabled space optical link. The experiment design employs a point-to-point free-space optical link configured to have asymmetric bandwidth. This link connects two networked systems running a DTN protocol implementation designed and written at JPL for use on spacecraft, and further configured for higher bandwidth performance. Comparing baseline data transmission metrics with and without periodic optical link interruptions, the experiment confirmed the DTN protocols' ability to handle real-world unexpected link outages while maintaining capability of reliably delivering data at relatively high rates. Finally, performance characterizations from this data suggest performance optimizations to configuration and protocols for future optical-specific DTN space link scenarios.

Safety in numbers: extinction arising from predator-driven Allee effects.

PubMed

Gregory, Stephen D; Courchamp, Franck

2010-05-01

Experimental evidence of extinction via an Allee effect (AE) is a priority as more species become threatened by human activity. Kramer & Drake (2010) begin the International Year of Biodiversity with the important--but double-edged--demonstration that predators can induce an AE in their prey. The good news is that their experiments help bridge the knowledge gap between theoretical and empirical AEs. The bad news is that this predator-driven AE precipitates the prey extinction via a demographic AE. Although their findings will be sensitive to departures from their experimental protocol, this link between predation and population extinction could have important consequences for many prey species.

Quantum measurements of signals from the Alphasat TDP1 laser communication terminal

NASA Astrophysics Data System (ADS)

Elser, D.; Günthner, K.; Khan, I.; Stiller, B.; Bayraktar, Ö.; Müller, C. R.; Saucke, K.; Tröndle, D.; Heine, F.; Seel, S.; Greulich, P.; Zech, H.; Gütlich, B.; Richter, I.; Philipp-May, S.; Marquardt, Ch.; Leuchs, G.

2017-09-01

Quantum optics [1] can be harnessed to implement cryptographic protocols that are verifiably immune against any conceivable attack [2]. Even quantum computers, that will break most current public keys [3, 4], cannot harm quantum encryption. Based on these intriguing quantum features, metropolitan quantum networks have been implemented around the world [5-15]. However, the long-haul link between metropolitan networks is currently missing [16]. Existing fiber infrastructure is not suitable for this purpose since classical telecom repeaters cannot relay quantum states [2]. Therefore, optical satellite-to-ground communication [17-22] lends itself to bridge intercontinental distances for quantum communication [23-40].

Bridging the gap in complementary and alternative medicine research: manualization as a means of promoting standardization and flexibility of treatment in clinical trials of acupuncture.

PubMed

Schnyer, Rosa N; Allen, John J B

2002-10-01

An important methodological challenge encountered in acupuncture clinical research involves the design of treatment protocols that help ensure standardization and replicability while allowing for the necessary flexibility to tailor treatments to each individual. Manualization of protocols used in clinical trials of acupuncture and other traditionally-based complementary and alternative medicine (CAM) systems facilitates the systematic delivery of replicable and standardized, yet individually-tailored treatments. To facilitate high-quality CAM acupuncture research by outlining a method for the systematic design and implementation of protocols used in CAM clinical trials based on the concept of treatment manualization. A series of treatment manuals was developed to systematically articulate the Chinese medical theoretical and clinical framework for a given Western-defined illness, to increase the quality and consistency of treatment, and to standardize the technical aspects of the protocol. In all, three manuals were developed for National Institutes of Health (NIH)-funded clinical trials of acupuncture for depression, spasticity in cerebral palsy, and repetitive stress injury. In Part I, the rationale underlying these manuals and the challenges encountered in creating them are discussed, and qualitative assessments of their utility are provided. In Part II, a methodology to develop treatment manuals for use in clinical trials is detailed, and examples are given. A treatment manual provides a precise way to train and supervise practitioners, enable evaluation of conformity and competence, facilitate the training process, and increase the ability to identify the active therapeutic ingredients in clinical trials of acupuncture.

Comparison of thermal and microwave paleointensity estimates in specimens that violate Thellier's laws

NASA Astrophysics Data System (ADS)

Grappone, J. M., Jr.; Biggin, A. J.; Barrett, T. J.; Hill, M. J.

2017-12-01

Deep in the Earth, thermodynamic behavior drives the geodynamo and creates the Earth's magnetic field. Determining how the strength of the field, its paleointensity (PI), varies with time, is vital to our understanding of Earth's evolution. Thellier-style paleointensity experiments assume the presence of non-interacting, single domain (SD) magnetic particles, which follow Thellier's laws. Most natural rocks however, contain larger, multi-domain (MD) or interacting single domain (ISD) particles that often violate these laws and cause experiments to fail. Even for samples that pass reliability criteria designed to minimize the impact of MD or ISD grains, different PI techniques can give systematically different estimates, implying violation of Thellier's laws. Our goal is to identify any disparities in PI results that may be explainable by protocol-specific MD and ISD behavior and determine optimum methods to maximize accuracy. Volcanic samples from the Hawai'ian SOH1 borehole previously produced method-dependent PI estimates. Previous studies showed consistently lower PI values when using a microwave (MW) system and the perpendicular method than using the original thermal Thellier-Thellier (OT) technique. However, the data were ambiguous regarding the cause of the discrepancy. The diverging estimates appeared to be either the result of using OT instead of the perpendicular method or the result of using MW protocols instead of thermal protocols. Comparison experiments were conducted using the thermal perpendicular method and microwave OT technique to bridge the gap. Preliminary data generally show that the perpendicular method gives lower estimates than OT for comparable Hlab values. MW estimates are also generally lower than thermal estimates using the same protocol.

Knowledge mobilization in bridging patient-practitioner-researcher boundaries: A systematic integrative review protocol.

PubMed

Cowdell, Fiona; Booth, Andrew; Appleby, Ben

2017-11-01

To review published literature to identify when and how patients and healthcare practitioners have been involved in knowledge mobilization activity and the impact this may have had on their care. Improving patient outcomes, satisfaction and quality of care is increasingly reliant on shared decision-making between health professionals and patients. Knowledge mobilization, at its simplest: "moving knowledge to where it can be most useful" is a growing field of academic study. To date, it appears that much effort has focused on moving knowledge from researchers to healthcare practitioners. Knowledge mobilization to patients is currently under-researched. Integrative review. Methods of integrative review will be used to address the review problem. PRISMA guidelines were used as a general framework to guide structuring and reporting the review. Elements of method-specific reporting guidelines for specific streams of evidence will be used as required. This review will aim to provide a broad and deep understanding of patient-practitioner-researcher engagement in knowledge mobilization activity. This synthesis of the extant literature should offer insights into the optimum characteristics of methods for bridging patient-practitioner-researcher boundaries in knowledge mobilization action. © 2017 John Wiley & Sons Ltd.

Life sciences domain analysis model

PubMed Central

Freimuth, Robert R; Freund, Elaine T; Schick, Lisa; Sharma, Mukesh K; Stafford, Grace A; Suzek, Baris E; Hernandez, Joyce; Hipp, Jason; Kelley, Jenny M; Rokicki, Konrad; Pan, Sue; Buckler, Andrew; Stokes, Todd H; Fernandez, Anna; Fore, Ian; Buetow, Kenneth H

2012-01-01

Objective Meaningful exchange of information is a fundamental challenge in collaborative biomedical research. To help address this, the authors developed the Life Sciences Domain Analysis Model (LS DAM), an information model that provides a framework for communication among domain experts and technical teams developing information systems to support biomedical research. The LS DAM is harmonized with the Biomedical Research Integrated Domain Group (BRIDG) model of protocol-driven clinical research. Together, these models can facilitate data exchange for translational research. Materials and methods The content of the LS DAM was driven by analysis of life sciences and translational research scenarios and the concepts in the model are derived from existing information models, reference models and data exchange formats. The model is represented in the Unified Modeling Language and uses ISO 21090 data types. Results The LS DAM v2.2.1 is comprised of 130 classes and covers several core areas including Experiment, Molecular Biology, Molecular Databases and Specimen. Nearly half of these classes originate from the BRIDG model, emphasizing the semantic harmonization between these models. Validation of the LS DAM against independently derived information models, research scenarios and reference databases supports its general applicability to represent life sciences research. Discussion The LS DAM provides unambiguous definitions for concepts required to describe life sciences research. The processes established to achieve consensus among domain experts will be applied in future iterations and may be broadly applicable to other standardization efforts. Conclusions The LS DAM provides common semantics for life sciences research. Through harmonization with BRIDG, it promotes interoperability in translational science. PMID:22744959

Perioperative Management of Patients on Clopidogrel (Plavix) Undergoing Major Lung Resection

PubMed Central

Ceppa, DuyKhanh P.; Welsby, Ian J.; Wang, Tracy Y.; Onaitis, Mark W.; Tong, Betty C.; Harpole, David H.; D’Amico, Thomas A.; Berry, Mark F.

2014-01-01

BACKGROUND Management of patients requiring antiplatelet therapy with clopidogrel (Plavix) and major lung resection must balance the risks of bleeding and cardiovascular events. We reviewed our experience with patients treated with clopidogrel perioperatively to examine outcomes, including results of a new strategy for high-risk patients. METHODS Patients who underwent major lung resection and received perioperative clopidogrel between January 2005 and September 2010 were reviewed. Initially, clopidogrel management consisted of discontinuation approximately 5 days before surgery and resumption immediately after surgery. Following July 2010, high-risk patients (drug-eluting coronary stent placement within prior year or previous coronary event after clopidogrel discontinuation) were admitted 2–3 days preoperatively and bridged with the intravenous GP IIb/IIIa receptor inhibitor eptifibatide (Integrilin) according to a multidisciplinary cardiology/anesthesiology/thoracic surgery protocol. Outcomes were compared to control patients (matched for preoperative risk factors and extent of pulmonary resection) who did not receive perioperative clopidogrel. RESULTS Fifty-four patients who had major lung resection between January 2005 and September 2010 and received clopidogrel perioperatively were matched with 108 controls. Both groups had similar mortality, postoperative length of stay, and no differences in the rates of perioperative transfusions, reoperations for bleeding, myocardial infarctions, and strokes. Seven of the 54 clopidogrel patients were admitted preoperatively for an eptifibatide bridge. Two of these patients received perioperative transfusions, but there were no mortalities, reoperations, myocardial infarctions, or stroke. CONCLUSIONS Patients taking clopidogrel can safely undergo major lung resection. Treatment with an eptifibatide bridge may minimize the risk of cardiovascular events in higher risk patients. PMID:21978871

Automatic mobile device synchronization and remote control system for high-performance medical applications.

PubMed

Constantinescu, L; Kim, J; Chan, C; Feng, D

2007-01-01

The field of telemedicine is in need of generic solutions that harness the power of small, easily carried computing devices to increase efficiency and decrease the likelihood of medical errors. Our study resolved to build a framework to bridge the gap between handheld and desktop solutions by developing an automated network protocol that wirelessly propagates application data and images prepared by a powerful workstation to handheld clients for storage, display and collaborative manipulation. To this end, we present the Mobile Active Medical Protocol (MAMP), a framework capable of nigh-effortlessly linking medical workstation solutions to corresponding control interfaces on handheld devices for remote storage, control and display. The ease-of-use, encapsulation and applicability of this automated solution is designed to provide significant benefits to the rapid development of telemedical solutions. Our results demonstrate that the design of this system allows an acceptable data transfer rate, a usable framerate for diagnostic solutions and enough flexibility to enable its use in a wide variety of cases. To this end, we also present a large-scale multi-modality image viewer as an example application based on the MAMP.

Cyberspace modernization. An interest protocol planning advisory

DOE Office of Scientific and Technical Information (OSTI.GOV)

Keliiaa, Curtis M.; McLane, Victor N.

A common challenge across the communications and information technology (IT) sectors is Internet + modernization + complexity + risk + cost. Cyberspace modernization and cyber security risks, issues, and concerns impact service providers, their customers, and the industry at large. Public and private sectors are struggling to solve the problem. New service opportunities lie in mobile voice, video, and data, and machine-to-machine (M2M) information and communication technologies that are migrating not only to predominant Internet Protocol (IP) communications, but also concurrently integrating IP, version 4 (IPv4) and IP, version 6 (IPv6). With reference to the Second Internet and the Internetmore » of Things, next generation information services portend business survivability in the changing global market. The planning, architecture, and design information herein is intended to increase infrastructure preparedness, security, interoperability, resilience, and trust in the midst of such unprecedented change and opportunity. This document is a product of Sandia National Laboratories Tribal Cyber and IPv6 project work. It is a Cyberspace Modernization objective advisory in support of bridging the digital divide through strategic partnership and an informed path forward.« less

A study of topologies and protocols for fiber optic local area network

NASA Technical Reports Server (NTRS)

Yeh, C.; Gerla, M.; Rodrigues, P.

1985-01-01

The emergence of new applications requiring high data traffic necessitates the development of high speed local area networks. Optical fiber is selected as the transmission medium due to its inherent advantages over other possible media and the dual optical bus architecture is shown to be the most suitable topology. Asynchronous access protocols, including token, random, hybrid random/token, and virtual token schemes, are developed and analyzed. Exact expressions for insertion delay and utilization at light and heavy load are derived, and intermediate load behavior is investigated by simulation. A new tokenless adaptive scheme whose control depends only on the detection of activity on the channel is shown to outperform round-robin schemes under uneven loads and multipacket traffic and to perform optimally at light load. An approximate solution to the queueing delay for an oscillating polling scheme under chaining is obtained and results are compared with simulation. Solutions to the problem of building systems with a large number of stations are presented, including maximization of the number of optical couplers, and the use of passive star/bus topologies, bridges and gateways.

Bridging the Gap between Scientific Data Producers and Consumers: A Provenance Approach

DOE Office of Scientific and Technical Information (OSTI.GOV)

Stephan, Eric G.; Pinheiro da Silva, Paulo; Kleese van Dam, Kerstin

2013-06-03

Despite the methodical and painstaking efforts made by scientists to record their scientific findings and protocols, a knowledge gap problem continues to persist today between producers of scientific results and consumers because technology is performing the exchange of data as opposed to scientists making direct contact. Provenance is a means to formalize how this knowledge is transferred. However, for it to be meaningful to scientists, the provenance research community needs continued contributions from the scientific community to extend and leverage provenance-based vocabularies and technology from the provenance community. Going forward the provenance community must also be vigilant to meet scalabilitymore » needs of data intensive science« less

Template Synthesis, Metalation, and Self-Assembly of Protic Gold(I)/(NHC)2 Tectons Driven by Metallophilic Interactions.

PubMed

Ruiz, Javier; García, Lucía; Sol, Daniel; Vivanco, Marilín

2016-07-11

A new protocol for the synthesis of protic bis(N-heterocyclic carbene) complexes of Au(I) by a stepwise metal-controlled coupling of isocyanide and propargylamine is described. They are used as tectons for the construction of supramolecular architectures through metalation and self-assembly. Notably a unique polymeric chain of Cu(I) with alternate Au(I) /bis(imidazolate) bridging scaffolds and strong unsupported Cu(I) -Cu(I) interactions has been generated, as well as a 28-metal-atoms cluster containing a nanopiece of Cu2 O trapped by peripheral Au(I) /bis(imidazolate) moieties. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Assessment of Safety and Effectiveness of the Extracorporeal Continuous-Flow Ventricular Assist Device (BR16010) Use as a Bridge-to-Decision Therapy for Severe Heart Failure or Refractory Cardiogenic Shock: Study Protocol for Single-Arm Non-randomized, Uncontrolled, and Investigator-Initiated Clinical Trial.

PubMed

Fukushima, Norihide; Tatsumi, Eisuke; Seguchi, Osamu; Takewa, Yoshiaki; Hamasaki, Toshimitsu; Onda, Kaori; Yamamoto, Haruko; Hayashi, Teruyuki; Fujita, Tomoyuki; Kobayashi, Junjiro

2018-06-08

The management of heart failure patients presenting in a moribund state remains challenging, despite significant advances in the field of ventricular assist systems. Bridge to decision involves using temporary devices to stabilize the hemodynamic state of such patients while further assessment is performed and a decision can be made regarding patient management. The purpose of this study (NCVC-BTD_01, National Cerebral and Cardiovascular Center-Bridge to Dicision_01) is to assess the safety and effectiveness of the newly developed extracorporeal continuous-flow ventricular assist system employing a disposable centrifugal pump with a hydrodynamically levitated bearing (BR16010) use as a bridge-to-decision therapy for patients with severe heart failure or refractory cardiogenic shock. NCVC-BTD_01 is a single-center, single-arm, open-label, exploratory, medical device, investigator-initiated clinical study. It is conducted at the National Cerebral and Cardiovascular Center in Japan. A total of nine patients will be enrolled in the study. The study was planned using Simon's minimax two-stage phase design. The primary endpoint is a composite of survival free of device-related serious adverse events and complications during device support. For left ventricular assistance, withdrawal of a trial device due to cardiac function recovery or exchange to other ventricular assist devices (VADs) for the purpose of bridge to transplantation (BTT) during 30 days after implantation will be considered study successes. For right ventricular assistance, withdrawal of tal device due to right ventricular function recovery within 30 days after implantation will be considered a study success. Secondary objectives include changes in brain natriuretic peptide levels (7 days after implantation of a trial device and the day of withdrawal of a trial device), period of mechanical ventricular support, changes in left ventricular ejection fraction (7 days after implantation of a trial device and the day of withdrawal of a trial device), and changes in left ventricular diastolic dimension (7 days after implantation of a trial device and the day of withdrawal of a trial device). We will disseminate the findings through regional, national, and international conferences and through peer-reviewed journals. UMIN Clinical Trials Registry (UMIN-CTR; R000033243) registered on 8 September 2017.

Health-social partnership intervention programme for community-dwelling older adults: a research protocol for a randomized controlled trial.

PubMed

Wong, Kwan Ching; Wong, Frances Kam Yuet; Chang, Katherine Ka Pik

2015-11-01

This paper aims to describe the research protocol that will be used to determine the effectiveness of a health-social partnership intervention programme among community-dwelling older adults. Ageing in place is a preferred option for overcoming challenges of the increasing prevalence of chronic diseases and the risk for hospitalization associated with the ageing population. Nevertheless, our knowledge of how to implement this concept is limited. The integrated efforts of health and social services may help to enable older adults to live with a sense of control over their daily life and to be independent to the fullest extent possible in the community. This is a randomized, controlled trial. Participants are community-dwelling older adults referred from a community centre. Sample size calculation was based on power analysis. The intervention group will receive the programme with the standard protocols guided by a comprehensive assessment-intervention-evaluation framework. Home visits and telephones follow-up will be employed as means of conducting the interventions and monitoring their progress. The customary care group will receive placebo social calls. The duration of the interventions will be 3 months. The study was funded by the School of Nursing in Hong Kong. Research Ethics Committee approval was obtained in September 2014. The results of this research are expected to enable older adults to stay in the community with optimal health and well-being. Health and social sciences are integrated into the practice in this research protocol. The scarce literature on this topic means that this study can also provide an opportunity to bridge the caring gap among older adults. © 2015 John Wiley & Sons Ltd.

Prospective randomized study of arthroscopic rotator cuff repair using an early versus delayed postoperative physical therapy protocol.

PubMed

Cuff, Derek J; Pupello, Derek R

2012-11-01

This study evaluated patient outcomes and rotator cuff healing after arthroscopic rotator cuff repair using a postoperative physical therapy protocol with early passive motion compared with a delayed protocol that limited early passive motion. The study enrolled 68 patients (average age, 63.2 years) who met inclusion criteria. All patients had a full-thickness crescent-shaped tear of the supraspinatus that was repaired using a transosseous equivalent suture-bridge technique along with subacromial decompression. In the early group, 33 patients were randomized to passive elevation and rotation that began at postoperative day 2. In the delayed group, 35 patients began the same protocol at 6 weeks. Patients were monitored clinically for a minimum of 12 months, and rotator cuff healing was assessed using ultrasound imaging. Both groups had similar improvements in preoperative to postoperative American Shoulder and Elbow Surgeons scores (early group: 43.9 to 91.9, P < .0001; delayed group: 41.0 to 92.8, P < .0001) and Simple Shoulder Test scores (early group: 5.5 to 11.1, P < .0001; delayed group: 5.1 to 11.1, P < .0001). There were no significant differences in patient satisfaction, rotator cuff healing, or range of motion between the early and delayed groups. Patients in the early group and delayed group both demonstrated very similar outcomes and range of motion at 1 year. There was a slightly higher rotator cuff healing rate in the delayed passive range of motion group compared with the early passive range of motion group (91% vs 85%). Copyright © 2012 Journal of Shoulder and Elbow Surgery Board of Trustees. Published by Mosby, Inc. All rights reserved.

Mobile technology intervention to improve care coordination between HIV and substance use treatment providers: development, training, and evaluation protocol.

PubMed

Claborn, Kasey; Becker, Sara; Ramsey, Susan; Rich, Josiah; Friedmann, Peter D

2017-03-14

People living with HIV (PLWH) with a substance use disorder (SUD) tend to receive inadequate medical care in part because of a siloed healthcare system in which HIV and substance use services are delivered separately. Ideal treatment requires an interdisciplinary, team-based coordinated care approach, but many structural and systemic barriers impede the integration of HIV and SUD services. The current protocol describes the development and preliminary evaluation of a care coordination intervention (CCI), consisting of a tablet-based mobile platform for HIV and SUD treatment providers, an interagency communication protocol, and a training protocol. We hypothesize that HIV and SUD treatment providers will find the CCI to be acceptable, and that after receipt of the CCI, providers will: exhibit higher retention in dual care among patients, report increased frequency and quality of communication, and report increased rates of relational coordination. A three phase approach is used to refine and evaluate the CCI. Phase 1 consists of in-depth qualitative interviews with 8 key stakeholders as well as clinical audits of participating HIV and SUD treatment agencies. Phase 2 contains functionality testing of the mobile platform with frontline HIV and SUD treatment providers, followed by refinement of the CCI. Phase 3 consists of a pre-, post-test trial with 30 SUD and 30 HIV treatment providers. Data will be collected at the provider, organization, and patient levels. Providers will complete assessments at baseline, immediately post-training, and at 1-, 3-, and 6-months post-training. Organizational data will be collected at baseline, 1-, 3-, and 6-months post training, while patient data will be collected at baseline and 6-months post training. This study will develop and evaluate a CCI consisting of a tablet-based mobile platform for treatment providers, an interagency communication protocol, and a training protocol as a means of improving the integration of care for PLWH who have a SUD. Results have the potential to advance the field by bridging gaps in a fragmented healthcare system, and improving treatment efficiency, work flow, and communication among interdisciplinary providers from different treatment settings. NCT02906215.

Cool Apps: Building Cryospheric Data Applications with Standards-Based Service Oriented Architecture

NASA Astrophysics Data System (ADS)

Oldenburg, J.; Truslove, I.; Collins, J. A.; Liu, M.; Lewis, S.; Brodzik, M.

2012-12-01

The National Snow and Ice Data Center (NSIDC) holds a large collection of cryospheric data, and is involved in a number of informatics research and development projects aimed at improving the discoverability and accessibility of these data. To develop high- quality software in a timely manner, we have adopted a Service- Oriented Architecture (SOA) approach for our core technical infrastructure development. Data services at NSIDC are internally exposed to other tools and applications through standards-based service interfaces. These standards include OAI-PMH (Open Archives Initiative Protocol for Metadata Harvesting), various OGC (Open Geospatial Consortium) standards including WMS (Web Map Service) and WFS (Web Feature Service), ESIP (Federation of Earth Sciences Information Partners) OpenSearch, and NSIDC-defined service endpoints which follow a RESTful architecture. By taking a standards-based approach, we are able to use off-the-shelf tools and libraries to consume, translate and broker these data services, and thus develop applications faster. Additionally, by exposing public interfaces to these services we provide valuable data services to technical collaborators; for example, NASA Reverb (http://reverb.echo.nasa.gov) uses NSIDC's WMS services. Our latest generation of web applications consume these data services directly. The most complete example of this is the Operation IceBridge Data Portal (http://nsidc.org/icebridge/ portal) which depends on many of the aforementioned services, retrieving data in several ways. The maps it displays are obtained through the use of WMS and WFS protocols from a MapServer instance hosted at NSIDC. Links to the scientific data collected on Operation IceBridge campaigns are obtained through ESIP OpenSearch requests service providers that encapsulate our metadata databases. These standards-based web services are also developed at NSIDC and are designed to be used independently of the Portal. This poster provides a visual representation of the relationships described above, with additional details and examples, and more generally outlines the benefits and challenges of this SOA approach.

Perioperative management of patients on clopidogrel (Plavix) undergoing major lung resection.

PubMed

Ceppa, Duykhanh P; Welsby, Ian J; Wang, Tracy Y; Onaitis, Mark W; Tong, Betty C; Harpole, David H; D'Amico, Thomas A; Berry, Mark F

2011-12-01

Management of patients requiring antiplatelet therapy with clopidogrel (Plavix) and major lung resection must balance the risks of bleeding and cardiovascular events. We reviewed our experience with patients treated with clopidogrel perioperatively to examine outcomes, including results of a new strategy for high-risk patients. Patients who underwent major lung resection and received perioperative clopidogrel between January 2005 and September 2010 were reviewed. Initially, clopidogrel management consisted of discontinuation approximately 5 days before surgery and resumption immediately after surgery. After July 2010, high-risk patients (drug-eluting coronary stent placement within prior year or previous coronary event after clopidogrel discontinuation) were admitted 2 to 3 days preoperatively and bridged with the intravenous glycoprotein IIb/IIIa receptor inhibitor eptifibatide (Integrilin) according to a multidisciplinary cardiology/anesthesiology/thoracic surgery protocol. Outcomes were compared with control patients (matched for preoperative risk factors and extent of pulmonary resection) who did not receive perioperative clopidogrel. Fifty-four patients who had major lung resection between January 2005 and September 2010 and received clopidogrel perioperatively were matched with 108 control subjects. Both groups had similar mortality, postoperative length of stay, and no differences in the rates of perioperative transfusions, reoperations for bleeding, myocardial infarctions, and strokes. Seven of the 54 clopidogrel patients were admitted preoperatively for an eptifibatide bridge. Two of these patients received perioperative transfusions, but there were no deaths, reoperations, myocardial infarctions, or stroke. Patients taking clopidogrel can safely undergo major lung resection. Treatment with an eptifibatide bridge may minimize the risk of cardiovascular events in higher risk patients. Copyright © 2011 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

An implementation of a data-transmission pipelining algorithm on Imote2 platforms

NASA Astrophysics Data System (ADS)

Li, Xu; Dorvash, Siavash; Cheng, Liang; Pakzad, Shamim

2011-04-01

Over the past several years, wireless network systems and sensing technologies have been developed significantly. This has resulted in the broad application of wireless sensor networks (WSNs) in many engineering fields and in particular structural health monitoring (SHM). The movement of traditional SHM toward the new generation of SHM, which utilizes WSNs, relies on the advantages of this new approach such as relatively low costs, ease of implementation and the capability of onboard data processing and management. In the particular case of long span bridge monitoring, a WSN should be capable of transmitting commands and measurement data over long network geometry in a reliable manner. While using single-hop data transmission in such geometry requires a long radio range and consequently a high level of power supply, multi-hop communication may offer an effective and reliable way for data transmissions across the network. Using a multi-hop communication protocol, the network relays data from a remote node to the base station via intermediary nodes. We have proposed a data-transmission pipelining algorithm to enable an effective use of the available bandwidth and minimize the energy consumption and the delay performance by the multi-hop communication protocol. This paper focuses on the implementation aspect of the pipelining algorithm on Imote2 platforms for SHM applications, describes its interaction with underlying routing protocols, and presents the solutions to various implementation issues of the proposed pipelining algorithm. Finally, the performance of the algorithm is evaluated based on the results of an experimental implementation.

The third dimension bridges the gap between cell culture and live tissue.

PubMed

Pampaloni, Francesco; Reynaud, Emmanuel G; Stelzer, Ernst H K

2007-10-01

Moving from cell monolayers to three-dimensional (3D) cultures is motivated by the need to work with cellular models that mimic the functions of living tissues. Essential cellular functions that are present in tissues are missed by 'petri dish'-based cell cultures. This limits their potential to predict the cellular responses of real organisms. However, establishing 3D cultures as a mainstream approach requires the development of standard protocols, new cell lines and quantitative analysis methods, which include well-suited three-dimensional imaging techniques. We believe that 3D cultures will have a strong impact on drug screening and will also decrease the use of laboratory animals, for example, in the context of toxicity assays.

Public channel cryptography: chaos synchronization and Hilbert's tenth problem.

PubMed

Kanter, Ido; Kopelowitz, Evi; Kinzel, Wolfgang

2008-08-22

The synchronization process of two mutually delayed coupled deterministic chaotic maps is demonstrated both analytically and numerically. The synchronization is preserved when the mutually transmitted signals are concealed by two commutative private filters, a convolution of the truncated time-delayed output signals or some powers of the delayed output signals. The task of a passive attacker is mapped onto Hilbert's tenth problem, solving a set of nonlinear Diophantine equations, which was proven to be in the class of NP-complete problems [problems that are both NP (verifiable in nondeterministic polynomial time) and NP-hard (any NP problem can be translated into this problem)]. This bridge between nonlinear dynamics and NP-complete problems opens a horizon for new types of secure public-channel protocols.

Left Ventricular Assist Device as a Bridge to Recovery for Patients With Advanced Heart Failure.

PubMed

Jakovljevic, Djordje G; Yacoub, Magdi H; Schueler, Stephan; MacGowan, Guy A; Velicki, Lazar; Seferovic, Petar M; Hothi, Sandeep; Tzeng, Bing-Hsiean; Brodie, David A; Birks, Emma; Tan, Lip-Bun

2017-04-18

Left ventricular assist devices (LVADs) have been used as an effective therapeutic option in patients with advanced heart failure, either as a bridge to transplantation, as destination therapy, or in some patients, as a bridge to recovery. This study evaluated whether patients undergoing an LVAD bridge-to-recovery protocol can achieve cardiac and physical functional capacities equivalent to those of healthy controls. Fifty-eight male patients-18 implanted with a continuous-flow LVAD, 16 patients with LVAD explanted (recovered patients), and 24 heart transplant candidates (HTx)-and 97 healthy controls performed a maximal graded cardiopulmonary exercise test with continuous measurements of respiratory gas exchange and noninvasive (rebreathing) hemodynamic data. Cardiac function was represented by peak exercise cardiac power output (mean arterial blood pressure × cardiac output) and functional capacity by peak exercise O 2 consumption. All patients demonstrated a significant exertional effort as demonstrated with the mean peak exercise respiratory exchange ratio >1.10. Peak exercise cardiac power output was significantly higher in healthy controls and explanted LVAD patients compared with other patients (healthy 5.35 ± 0.95 W; explanted 3.45 ± 0.72 W; LVAD implanted 2.37 ± 0.68 W; and HTx 1.31 ± 0.31 W; p < 0.05), as was peak O 2 consumption (healthy 36.4 ± 10.3 ml/kg/min; explanted 29.8 ± 5.9 ml/kg/min; implanted 20.5 ± 4.3 ml/kg/min; and HTx 12.0 ± 2.2 ml/kg/min; p < 0.05). In the LVAD explanted group, 38% of the patients achieved peak cardiac power output and 69% achieved peak O 2 consumption within the ranges of healthy controls. The authors have shown that a substantial number of patients who recovered sufficiently to allow explantation of their LVAD can even achieve cardiac and physical functional capacities nearly equivalent to those of healthy controls. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

Factors associated with short interpregnancy interval in women who plan postpartum LARC: a retrospective study.

PubMed

Harney, Clare; Dude, Annie; Haider, Sadia

2017-03-01

Pregnancies conceived after a short interpregnancy interval (IPI), within 18 months of delivery, and unintended pregnancies are both associated with health risks. We studied risk factors for conception after a short IPI among postpartum women who plan long-acting reversible contraception (LARC). A retrospective review of a cohort of women who delivered at University of Illinois Hospital from 2005 to 2010 and were discharged with a plan for interval LARC was performed. Outcomes were (1) attendance at a postpartum visit (PPV), (2) LARC placement (3) and conception after a short IPI. We compared variables using chi-squared test, Student's t tests and multivariable logistic regression. Of 3548 women, 62.0% attended a PPV, 36.5% received LARC and 11.4% conceived after a short IPI. After logistic regression, women who were multiparous [odds ratio (OR) 0.77, 95% confidence interval (CI) 0.65-0.91] or chose a temporary contraceptive "bridge" to LARC (OR 0.74, 95% CI 0.58-0.94) were less likely to attend their PPV. Women who missed their PPV (OR 0.06, 95% CI 0.05-0.08) or chose a bridge (OR 0.66, 95% CI 0.50-0.88) were less likely to receive LARC. Finally, women who did not receive LARC (OR 4.8, 95% CI 3.50-6.70), were multiparous (OR 1.69, 95% CI 1.32-2.15) or teenaged (OR 2.12, 95% CI 1.61-2.79) were more likely to conceive after a short IPI. Women who receive postpartum LARC are less likely to become pregnant after a short IPI. Missing the PPV, multiparity and plan for a contraceptive bridge may all contribute to a patient not receiving planned LARC. Efforts to decrease unintended pregnancy after a short IPI should focus on decreasing barriers to planned postpartum LARC. Provision of temporary bridge contraception until interval LARC may not mitigate the significant barriers associated with interval postpartum placement protocols. Copyright © 2017 Elsevier Inc. All rights reserved.

Lab-On-a-Chip Application Development (LOCAD): Bridging Technology Readiness for Exploration

NASA Technical Reports Server (NTRS)

Spearing, Scott F.; Jenkins, Andy

2004-01-01

At Marshall Space Flight Center we have established a capability to investigate the use of microfluidics for space flight. The Lab-On-a-Chip Application Development (LOCAD) team has created a program for advancing Technology Readiness Levels (TRL) of 1 and 2 to TRL 6 and 7, quickly and economically for Lab-On-a-Chip (LOC) applications. Scientists and engineers can utilize LOCAD'S process to efficiently learn about microfluidics and determine if microfluidics is applicable to their needs. Once the applicability has been determined, LOCAD can then perform tests to develop the new fluidic protocols which are different from macro-scale chemical reaction protocols. With this information new micro-fluidic devices can be created and tested. Currently, LOCAD is focused on using microfluidics for both Environmental Monitoring & Control, and Medical Systems. Eventually, handheld portable units utilizing LOC technology will perform rapid tests to determine water quality, and microbial contamination levels. Since LOC technology is drastically reduced in physical size, it thereby reduces power, weight, volume, and sample requirements, a big advantage considering the resource constraints associated with spaceflight. Another one of LOCAD's current activities is the development of a microfluidic system to aid in the search for life on Mars.

A New Integrated Approach to Taxonomy: The Fusion of Molecular and Morphological Systematics with Type Material in Benthic Foraminifera

PubMed Central

Roberts, Angela; Austin, William; Evans, Katharine; Bird, Clare; Schweizer, Magali; Darling, Kate

2016-01-01

A robust and consistent taxonomy underpins the use of fossil material in palaeoenvironmental research and long-term assessment of biodiversity. This study presents a new integrated taxonomic protocol for benthic foraminifera by unequivocally reconciling the traditional taxonomic name to a specific genetic type. To implement this protocol, a fragment of the small subunit ribosomal RNA (SSU rRNA) gene is used in combination with 16 quantitative morphometric variables to fully characterise the benthic foraminiferal species concept of Elphidium williamsoni Haynes, 1973. A combination of live contemporary topotypic specimens, original type specimens and specimens of genetic outliers were utilised in this study. Through a series of multivariate statistical tests we illustrate that genetically characterised topotype specimens are morphologically congruent with both the holotype and paratype specimens of E. williamsoni Haynes, 1973. We present the first clear link between morphologically characterised type material and the unique SSU rRNA genetic type of E. williamsoni. This example provides a standard framework for the benthic foraminifera which bridges the current discontinuity between molecular and morphological lines of evidence, allowing integration with the traditional Linnaean roots of nomenclature to offer a new prospect for taxonomic stability. PMID:27388271

The protonation states of oxo-bridged Mn(IV) dimers resolved by experimental and computational Mn K pre-edge X-ray absorption spectroscopy.

PubMed

Krewald, Vera; Lassalle-Kaiser, Benedikt; Boron, Thaddeus T; Pollock, Christopher J; Kern, Jan; Beckwith, Martha A; Yachandra, Vittal K; Pecoraro, Vincent L; Yano, Junko; Neese, Frank; DeBeer, Serena

2013-11-18

In nature, the protonation of oxo bridges is a commonly encountered mechanism for fine-tuning chemical properties and reaction pathways. Often, however, the protonation states are difficult to establish experimentally. This is of particular importance in the oxygen evolving complex of photosystem II, where identification of the bridging oxo protonation states is one of the essential requirements toward unraveling the mechanism. In order to establish a combined experimental and theoretical protocol for the determination of protonation states, we have systematically investigated a series of Mn model complexes by Mn K pre-edge X-ray absorption spectroscopy. An ideal test case for selective bis-μ-oxo-bridge protonation in a Mn dimer is represented by the system [Mn(IV)2(salpn)2(μ-OHn)2](n+). Although the three species [Mn(IV)2(salpn)2(μ-O)2], [Mn(IV)2(salpn)2(μ-O)(μ-OH)](+) and [Mn(IV)2(salpn)2(μ-OH)2](2+) differ only in the protonation of the oxo bridges, they exhibit distinct differences in the pre-edge region while maintaining the same edge energy. The experimental spectra are correlated in detail to theoretically calculated spectra. A time-dependent density functional theory approach for calculating the pre-edge spectra of molecules with multiple metal centers is presented, using both high spin (HS) and broken symmetry (BS) electronic structure solutions. The most intense pre-edge transitions correspond to an excitation of the Mn 1s core electrons into the unoccupied orbitals of local e(g) character (d(z)(2) and d(xy) based in the chosen coordinate system). The lowest energy experimental feature is dominated by excitations of 1s-α electrons, and the second observed feature is primarily attributed to 1s-β electron excitations. The observed energetic separation is due to spin polarization effects in spin-unrestricted density functional theory and models final state multiplet effects. The effects of spin polarization on the calculated Mn K pre-edge spectra, in both the HS and BS solutions, are discussed in terms of the strength of the antiferromagnetic coupling and associated changes in the covalency of Mn-O bonds. The information presented in this paper is complemented with the X-ray emission spectra of the same compounds published in an accompanying paper. Taken together, the two studies provide the foundation for a better understanding of the X-ray spectroscopic data of the oxygen evolving complex (OEC) in photosystem II.

Three Bridge Fryer's Ford Bridge, Nimrod Bridge, and Ward's ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Three Bridge - Fryer's Ford Bridge, Nimrod Bridge, and Ward's Crossing Bridge - Fryer's Ford Bridge, Spanning East Fork of Point Remove Creek at Fryer Bridge Road (CR 67), Solgohachia, Conway County, AR

47 CFR 80.1007 - Bridge-to-bridge radiotelephone installation.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 47 Telecommunication 5 2011-10-01 2011-10-01 false Bridge-to-bridge radiotelephone installation. 80.1007 Section 80.1007 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND... Bridge-to-Bridge Act § 80.1007 Bridge-to-bridge radiotelephone installation. Use of the bridge-to-bridge...

47 CFR 80.1007 - Bridge-to-bridge radiotelephone installation.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 5 2010-10-01 2010-10-01 false Bridge-to-bridge radiotelephone installation. 80.1007 Section 80.1007 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND... Bridge-to-Bridge Act § 80.1007 Bridge-to-bridge radiotelephone installation. Use of the bridge-to-bridge...

Designing Uniquely Addressable Bio-orthogonal Synthetic Scaffolds for DNA and RNA Origami.

PubMed

Kozyra, Jerzy; Ceccarelli, Alessandro; Torelli, Emanuela; Lopiccolo, Annunziata; Gu, Jing-Ying; Fellermann, Harold; Stimming, Ulrich; Krasnogor, Natalio

2017-07-21

Nanotechnology and synthetic biology are rapidly converging, with DNA origami being one of the leading bridging technologies. DNA origami was shown to work well in a wide array of biotic environments. However, the large majority of extant DNA origami scaffolds utilize bacteriophages or plasmid sequences thus severely limiting its future applicability as a bio-orthogonal nanotechnology platform. In this paper we present the design of biologically inert (i.e., "bio-orthogonal") origami scaffolds. The synthetic scaffolds have the additional advantage of being uniquely addressable (unlike biologically derived ones) and hence are better optimized for high-yield folding. We demonstrate our fully synthetic scaffold design with both DNA and RNA origamis and describe a protocol to produce these bio-orthogonal and uniquely addressable origami scaffolds.

[Importance of clinical trial design and standardized implementation in ophthalmology].

PubMed

Xu, Xun

2013-06-01

Clinical trial is an important medical research method, as well as the bridge of translational medicine. The results of scientific evidences are useful to make clinical practice guidelines. At present,much experience of carrying out ophthalmology clinical trials has been obtained and achieved, but there are still some scientific, practical and ethical problems to be solved,because of their impact on the authenticity and reliability of the results. Therefore, attaching great importance to design of the clinical research and implement of the standardization would be the goal and the development direction. Clinical trial design rely on objective, follow international design principles on the ethics,randomization, blinding and placebo setting. During the trial implementation, personnel training,project management and monitoring would help to reduce protocol deviation and ensure data authenticity.

A Multi-Center Space Data System Prototype Based on CCSDS Standards

NASA Technical Reports Server (NTRS)

Rich, Thomas M.

2016-01-01

Deep space missions beyond earth orbit will require new methods of data communications in order to compensate for increasing Radio Frequency (RF) propagation delay. The Consultative Committee for Space Data Systems (CCSDS) standard protocols Spacecraft Monitor & Control (SM&C), Asynchronous Message Service (AMS), and Delay/Disruption Tolerant Networking (DTN) provide such a method. However, the maturity level of this protocol stack is insufficient for mission inclusion at this time. This Space Data System prototype is intended to provide experience which will raise the Technical Readiness Level (TRL) of this protocol set. In order to reduce costs, future missions can take advantage of these standard protocols, which will result in increased interoperability between control centers. This prototype demonstrates these capabilities by implementing a realistic space data system in which telemetry is published to control center applications at the Jet Propulsion Lab (JPL), the Marshall Space Flight Center (MSFC), and the Johnson Space Center (JSC). Reverse publishing paths for commanding from each control center are also implemented. The target vehicle consists of realistic flight computer hardware running Core Flight Software (CFS) in the integrated Power, Avionics, and Power (iPAS) Pathfinder Lab at JSC. This prototype demonstrates a potential upgrade path for future Deep Space Network (DSN) modification, in which the automatic error recovery and communication gap compensation capabilities of DTN would be exploited. In addition, SM&C provides architectural flexibility by allowing new service providers and consumers to be added efficiently anywhere in the network using the common interface provided by SM&C's Message Abstraction Layer (MAL). In FY 2015, this space data system was enhanced by adding telerobotic operations capability provided by the Robot API Delegate (RAPID) family of protocols developed at NASA. RAPID is one of several candidates for consideration and inclusion in a new international standard being developed by the CCSDS Telerobotic Operations Working Group. Software gateways for the purpose of interfacing RAPID messages with the existing SM&C based infrastructure were developed. Telerobotic monitor, control, and bridge applications were written in the RAPID framework, which were then tailored to the NAO telerobotic test article hardware, a product of Aldebaran Robotics.

Bridge over troubled proline: assignment of intrinsically disordered proteins using (HCA)CON(CAN)H and (HCA)N(CA)CO(N)H experiments concomitantly with HNCO and i(HCA)CO(CA)NH.

PubMed

Hellman, Maarit; Piirainen, Henni; Jaakola, Veli-Pekka; Permi, Perttu

2014-01-01

NMR spectroscopy is by far the most versatile and information rich technique to study intrinsically disordered proteins (IDPs). While NMR is able to offer residue level information on structure and dynamics, assignment of chemical shift resonances in IDPs is not a straightforward process. Consequently, numerous pulse sequences and assignment protocols have been developed during past several years, targeted especially for the assignment of IDPs, including experiments that employ H(N), H(α) or (13)C detection combined with two to six indirectly detected dimensions. Here we propose two new HN-detection based pulse sequences, (HCA)CON(CAN)H and (HCA)N(CA)CO(N)H, that provide correlations with (1)H(N)(i - 1), (13)C'(i - 1) and (15)N(i), and (1)H(N)(i + 1), (13)C'(i) and (15)N(i) frequencies, respectively. Most importantly, they offer sequential links across the proline bridges and enable filling the single proline gaps during the assignment. We show that the novel experiments can efficiently complement the information available from existing HNCO and intraresidual i(HCA)CO(CA)NH pulse sequences and their concomitant usage enabled >95 % assignment of backbone resonances in cytoplasmic tail of adenosine receptor A2A in comparison to 73 % complete assignment using the HNCO/i(HCA)CO(CA)NH data alone.

47 CFR 80.331 - Bridge-to-bridge communication procedure.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 47 Telecommunication 5 2011-10-01 2011-10-01 false Bridge-to-bridge communication procedure. 80..., Alarm, Urgency and Safety Procedures § 80.331 Bridge-to-bridge communication procedure. (a) Vessels subject to the Bridge-to-Bridge Act transmitting on the designated navigational frequency must conduct...

47 CFR 80.331 - Bridge-to-bridge communication procedure.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 5 2010-10-01 2010-10-01 false Bridge-to-bridge communication procedure. 80..., Alarm, Urgency and Safety Procedures § 80.331 Bridge-to-bridge communication procedure. (a) Vessels subject to the Bridge-to-Bridge Act transmitting on the designated navigational frequency must conduct...

The Osseus platform: a prototype for advanced web-based distributed simulation

NASA Astrophysics Data System (ADS)

Franceschini, Derrick; Riecken, Mark

2016-05-01

Recent technological advances in web-based distributed computing and database technology have made possible a deeper and more transparent integration of some modeling and simulation applications. Despite these advances towards true integration of capabilities, disparate systems, architectures, and protocols will remain in the inventory for some time to come. These disparities present interoperability challenges for distributed modeling and simulation whether the application is training, experimentation, or analysis. Traditional approaches call for building gateways to bridge between disparate protocols and retaining interoperability specialists. Challenges in reconciling data models also persist. These challenges and their traditional mitigation approaches directly contribute to higher costs, schedule delays, and frustration for the end users. Osseus is a prototype software platform originally funded as a research project by the Defense Modeling & Simulation Coordination Office (DMSCO) to examine interoperability alternatives using modern, web-based technology and taking inspiration from the commercial sector. Osseus provides tools and services for nonexpert users to connect simulations, targeting the time and skillset needed to successfully connect disparate systems. The Osseus platform presents a web services interface to allow simulation applications to exchange data using modern techniques efficiently over Local or Wide Area Networks. Further, it provides Service Oriented Architecture capabilities such that finer granularity components such as individual models can contribute to simulation with minimal effort.

Selecting and utilizing Populus and Salix for landfill covers: implications for leachate irrigation.

PubMed

Zalesny, Ronald S; Bauer, Edmund O

2007-01-01

The success of using Populus and Salix for phytoremediation has prompted further use of leachate as a combination of irrigation and fertilization for the trees. A common protocol for such efforts has been to utilize a limited number of readily-available genotypes with decades of deployment in other applications, such as fiber or windbreaks. However, it may be possible to increase phytoremediation success with proper genotypic screening and selection, followed by the field establishment of clones that exhibited favorable potential for cleanup of specific contaminants. There is an overwhelming need for testing and subsequent deployment of diverse Populus and Salix genotypes, given current availability of clonal material and the inherent genetic variation among and within these genera. Therefore, we detail phyto-recurrent selection, a method that consists of revising and combining crop and tree improvement protocols to meet the objective of utilizing superior Populus and Salix clones for remediation applications. Although such information is lacking for environmental clean-up technologies, centuries of plant selection success in agronomy, horticulture, and forestry validate the need for similar approaches in phytoremediation. We bridge the gap between these disciplines by describing project development, clone selection, tree establishment, and evaluation of success metrics in the context of their importance to utilizing trees for phytoremediation.

Guardrails for use on historic bridges: volume 2--bridge deck overhang design.

DOT National Transportation Integrated Search

2016-11-01

Bridges that are designated historic present a special challenge to bridge engineers whenever rehabilitation work or improvements are : made to the bridges. Federal and state laws protect historically significant bridges, and railings on these bridge...

Bridging the Gap: using an interrupted time series design to evaluate systems reform addressing refugee maternal and child health inequalities.

PubMed

Yelland, Jane; Riggs, Elisha; Szwarc, Josef; Casey, Sue; Dawson, Wendy; Vanpraag, Dannielle; East, Chris; Wallace, Euan; Teale, Glyn; Harrison, Bernie; Petschel, Pauline; Furler, John; Goldfeld, Sharon; Mensah, Fiona; Biro, Mary Anne; Willey, Sue; Cheng, I-Hao; Small, Rhonda; Brown, Stephanie

2015-04-30

The risk of poor maternal and perinatal outcomes in high-income countries such as Australia is greatest for those experiencing extreme social and economic disadvantage. Australian data show that women of refugee background have higher rates of stillbirth, fetal death in utero and perinatal mortality compared with Australian born women. Policy and health system responses to such inequities have been slow and poorly integrated. This protocol describes an innovative programme of quality improvement and reform in publically funded universal health services in Melbourne, Australia, that aims to address refugee maternal and child health inequalities. A partnership of 11 organisations spanning health services, government and research is working to achieve change in the way that maternity and early childhood health services support families of refugee background. The aims of the programme are to improve access to universal health care for families of refugee background and build organisational and system capacity to address modifiable risk factors for poor maternal and child health outcomes. Quality improvement initiatives are iterative, co-designed by partners and implemented using the Plan Do Study Act framework in four maternity hospitals and two local government maternal and child health services. Bridging the Gap is designed as a multi-phase, quasi-experimental study. Evaluation methods include use of interrupted time series design to examine health service use and maternal and child health outcomes over a 3-year period of implementation. Process measures will examine refugee families' experiences of specific initiatives and service providers' views and experiences of innovation and change. It is envisaged that the Bridging the Gap program will provide essential evidence to support service and policy innovation and knowledge about what it takes to implement sustainable improvements in the way that health services support vulnerable populations, within the constraints of existing resources.

47 CFR 80.163 - Operator requirements of the Bridge-to-Bridge Act.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 47 Telecommunication 5 2011-10-01 2011-10-01 false Operator requirements of the Bridge-to-Bridge... Requirements § 80.163 Operator requirements of the Bridge-to-Bridge Act. Each ship subject to the Bridge-to-Bridge Act must have on board a radio operator who holds a restricted radiotelephone operator permit or...

78 FR 45863 - Drawbridge Operation Regulation; Willamette River at Portland, OR

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-30

... operating schedule that govern four Multnomah County bridges: The Broadway Bridge, mile 11.7, the Burnside Bridge, mile 12.4, the Morrison Bridge, mile 12.8, and the Hawthorne Bridge, mile 13.1, all crossing the... the Broadway Bridge, mile 11.7, the Burnside Bridge, mile 12.4, the Morrison Bridge, mile 12.8, and...

77 FR 43164 - Drawbridge Operation Regulation; Willamette River, Portland, OR

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-24

... schedule that governs four Multnomah County bridges: The Broadway Bridge, mile 11.7, the Burnside Bridge, mile 12.4, the Morrison Bridge, mile 12.8, and the Hawthorne Bridge, mile 13.1, all crossing the..., mile 11.7, the Burnside Bridge, mile 12.4, the Morrison Bridge, mile 12.8, and the Hawthorne Bridge...

47 CFR 80.163 - Operator requirements of the Bridge-to-Bridge Act.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 5 2010-10-01 2010-10-01 false Operator requirements of the Bridge-to-Bridge... Requirements § 80.163 Operator requirements of the Bridge-to-Bridge Act. Each ship subject to the Bridge-to-Bridge Act must have on board a radio operator who holds a restricted radiotelephone operator permit or...

Simple model of cable-stayed bridge deck subjected to static wind loading

NASA Astrophysics Data System (ADS)

Kang, Yi-Lung; Wang, Yang Cheng

1997-05-01

Cable-stayed bridges have been known since 18th century with aesthetics design. The structural system and the structural behavior are significantly different from those of continuous bridges. Compared to continuous bridge, cable- stayed bridges have more flexure bridge deck than those of continuous bridges.On the other hand, cable-stayed bridges have less stiffness to resist wind loading especially for lateral loads. The first considering of bridge engineering is safety. In 1940's, Tacoma Narrows Suspension Bridge destroyed by wind loading is a good example even though it is not a cable-stayed bridge. After the bridge was destroyed, a lot of research articles have been published regarding cable supported bridge subjected to wind loading. In recent days, high strength materials have been served. The bridge engineers use the advantages to expand the span length of cable-stayed bridges. Due to the span length increased and the use of high strength materials, cable- stayed bridges have more significant nonlinear behavior subjected to wind loading. In this paper, a slice bridge deck of cable-stayed bridge connected to internal support cables is considered. The deck has been considered to be subjected to lateral static wind loading. Since cables can not take compressive force, the deck has strongly nonlinear behavior even though the materials are linear elastic. Several primary load combinations have ben considered in this paper such as the bridge deck supposed to be moved horizontally without rotation or the bridge deck supposed to be moved horizontally with rotational deformation. The mathematical formulas and the numerical solutions are found and represented in graphical forms. The results can be provided to bridge designers and researchers for further study of this type of structure subjected to wind loading.

Dynamic response for structural health monitoring of the Penang (I) cable-stayed bridge

NASA Astrophysics Data System (ADS)

Mohammed, M. I.; Sulaeman, E.; Mustapha, F.

2017-03-01

The paper discusses the dynamic response of the Penang (I) cable stayed bridge structure under various moving load representing typical traffic load of the bridge. The bridge has a total span of 440 m excluding the transition bridge that assumed to be not connected structurally to the main bridge structure. The bridge that links the fast growing Pinang Island and the Malaysian Mainland Peninsula has been known to be fully utilized which leads to the construction of Penang (II) bridge and now the third one. Due to highly traffic use of the bridge that may lead to reduction of the bridge design life, the dynamic response of the bridge becomes important to predict critical part of the bridge structure elements including the main girder and the 144 stay cables. The present study reveals that, due to flexible nature of the cable stayed bridge, the moving load that interacts with the natural dynamic characteristics of the bridge, gives significant stress increment compare to proportional static load especially when the moving load is un-symmetric. For this reason, several classes of typical vehicle passing the bridge with various vehicle speeds are investigated to demonstrate their effect on the bridge displacement, internal forces and stresses. The results can be used for further fatigue assessment of the bridge.

47 CFR 80.309 - Watch required by the Bridge-to-Bridge Act.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 47 Telecommunication 5 2011-10-01 2011-10-01 false Watch required by the Bridge-to-Bridge Act. 80... Safety Watches § 80.309 Watch required by the Bridge-to-Bridge Act. In addition to the watch requirement contained in § 80.148, all vessels subject to the Bridge-to-Bridge Act must keep a watch on the designated...

47 CFR 80.309 - Watch required by the Bridge-to-Bridge Act.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 47 Telecommunication 5 2010-10-01 2010-10-01 false Watch required by the Bridge-to-Bridge Act. 80... Safety Watches § 80.309 Watch required by the Bridge-to-Bridge Act. In addition to the watch requirement contained in § 80.148, all vessels subject to the Bridge-to-Bridge Act must keep a watch on the designated...

Vibration analysis of the Second Saikai Bridge—a concrete filled tubular (CFT) arch bridge

NASA Astrophysics Data System (ADS)

Yoshimura, Mistuhiro; Wu, Qingxiong; Takahashi, Kazuo; Nakamura, Shozo; Furukawa, Kazuyoshi

2006-02-01

Concrete-filled steel tubular (CFT) arch bridges have been rapidly developing in China since 1990. Research has focused on the static behavior, thermal stress and erection technique, however, and there has been very little research of natural vibrations and dynamic responses of these bridges. Japan's first CFT arch bridge in highway bridges, the Second Saikai Bridge, is now under construction in Nagasaki Prefecture. Furthermore, this bridge has a pedestrian bridge that is suspended under the girder, which is rare. Therefore, the natural vibration properties are examined, and the influence of pedestrian bridge structure on the natural vibration of main bridge is discussed first. Response analysis under a moving vehicle and pedestrian is carried out, and the response characteristics and response level are clarified. The natural vibrations and responses are compared to those of CFT arch bridges that have been constructed in China. Results show the fine performance of both main bridge and pedestrian bridge of the Second Saikai Bridge.

Feasibility, Acceptability and Preliminary Treatment Outcomes in a School-Based CBT Intervention Program for Adolescents with ASD and Anxiety in Singapore.

PubMed

Drmic, Irene E; Aljunied, Mariam; Reaven, Judy

2017-12-01

Adolescents with autism spectrum disorder (ASD) are at high risk for anxiety difficulties and disorders. Clinic-based cognitive behavioral therapy (CBT) is effective; however, few published school-based CBT programs for youth with ASD exist. In this study, the Facing Your Fears CBT protocol was adapted for delivery and piloted within a school setting by non-clinicians, with culturally appropriate adaptations. 44 13-15 aged youth with ASD from 22 mainstream schools in Singapore participated. Feasibility, acceptability and preliminary treatment outcomes were examined. Decreases in youth and parent reported anxiety symptoms were reported. Staff and parents found the program useful. Stakeholder support was important for implementation. Initial findings reflect the importance of carefully bridging research-to-practice for youth with ASD and anxiety.

Bridging the gap between preventive and restorative dentistry: identification of caries risk factors and strategies for minimizing risk.

PubMed

Maragliano-Muniz, Pamela

2013-10-01

Following the introduction of CAMBRA (Caries Management by Risk Assessment) in 2007, a number of recommendations for office protocols were introduced, and many companies have formulated products and procedures for implementing CAMBRA. As a result, the implementation of a caries management program can be confounding and overwhelming to a dental practitioner. Understanding risk factors as they contribute to the caries process can help mitigate confusion and guide the practitioner when selecting materials for their practice. Ultimately, knowing how the risk factors play a role in the progression of dental caries will lead to appropriate risk management and product recommendations. The purpose of this article is to discuss the contribution of risk factors to the caries process and to introduce strategies that restorative dentists can utilize to minimize caries risk.

Adopting Internet Standards for Orbital Use

NASA Technical Reports Server (NTRS)

Wood, Lloyd; Ivancic, William; da Silva Curiel, Alex; Jackson, Chris; Stewart, Dave; Shell, Dave; Hodgson, Dave

2005-01-01

After a year of testing and demonstrating a Cisco mobile access router intended for terrestrial use onboard the low-Earth-orbiting UK-DMC satellite as part of a larger merged ground/space IP-based internetwork, we reflect on and discuss the benefits and drawbacks of integration and standards reuse for small satellite missions. Benefits include ease of operation and the ability to leverage existing systems and infrastructure designed for general use, as well as reuse of existing, known, and well-understood security and operational models. Drawbacks include cases where integration work was needed to bridge the gaps in assumptions between different systems, and where performance considerations outweighed the benefits of reuse of pre-existing file transfer protocols. We find similarities with the terrestrial IP networks whose technologies we have adopted and also some significant differences in operational models and assumptions that must be considered.

The extended TRIP supporting VoIP routing reservation with distributed QoS

NASA Astrophysics Data System (ADS)

Wang, Furong; Wu, Ye

2004-04-01

In this paper, an existing protocol, i.e. TRIP (Telephony Routing over IP) is developed to provide distributed QoS when making resource reservations for VoIP services such as H.323, SIP. Enhanced LSs (location servers) are deployed in ITADs (IP Telephony Administrative Domains) to take in charge of intra-domain routing policy because of small propagation price. It is an easy way to find an IP telephone route for intra-domain VoIP media association and simultaneously possess intra-domain load balancing features. For those routing reservations bridging domains, inter-domain routing policy is responsible for finding the shortest inter-domain route with enough resources. I propose the routing preference policy based on QoS price when the session traffic is shaped by a token bucket, related QoS messages, and message cooperation.

Convergent solid-phase synthesis of hirudin.

PubMed

Goulas, Spyros; Gatos, Dimitrios; Barlos, Kleomenis

2006-02-01

Hirudin variant 1 (HV1), a small protein consisting of 65 amino acids and three disulfide bonds, was synthesized by using Fmoc-based convergent methods on 2-chlorotrityl resin (CLTR). The linear sequence was assembled by the sequential condensation of 7 protected fragments, on the resin-bound 55-65 fragment. The conditions of fragment assembly were carefully studied to determine the most efficient synthetic protocol. Crude reduced [Cys(16, 28)(Acm)]-HV1 thus obtained was easily purified to homogeneity by RP-HPLC. Disulfide bridges were successfully formed by a two-step procedure, involving an oxidative folding step to form Cys(6)-Cys(14) and Cys(22)-Cys(39) linkages, followed by iodine oxidation to form the Cys(16)-Cys(28) bond. The correct disulfide bond alignment was established by peptide mapping using Staphylococcus aureus V8 protease at pH 4.5.

49 CFR 237.111 - Review of bridge inspection reports.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 4 2011-10-01 2011-10-01 false Review of bridge inspection reports. 237.111... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION BRIDGE SAFETY STANDARDS Bridge Inspection § 237.111 Review of bridge inspection reports. Bridge inspection reports shall be reviewed by railroad bridge supervisors and railroad...

49 CFR 237.111 - Review of bridge inspection reports.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Review of bridge inspection reports. 237.111... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION BRIDGE SAFETY STANDARDS Bridge Inspection § 237.111 Review of bridge inspection reports. Bridge inspection reports shall be reviewed by railroad bridge supervisors and railroad...

Field performance of timber bridges. 7, Connell Lake stress-laminated deck bridge

Treesearch

L. E. Hislop; M. A. Ritter

The Connell Lake bridge was constructed in early 1991 on the Tongass National Forest, Alaska, as a demonstration bridge under the Timber Bridge Initiative. The bridge is a stress-laminated deck structure with an approximate 36-ft length and 18-ft width and is the first known stress-laminated timber bridge constructed in Alaska. Performance of the bridge was monitored...

25. VIEW OF McGREGOR BRIDGE (18811936), CROSSING THE MERRIMACK RIVER ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

25. VIEW OF McGREGOR BRIDGE (1881-1936), CROSSING THE MERRIMACK RIVER AT BRIDGE STREET, LOOKING SOUTHEAST. NORTH ELEVATION OF DOUBLE-DECKED, THREE-SPAN DOUGLAS PATENT PARABOLIC IRON TRUSS ERECTED BY CORRUGATED METAL COMPANY (BERLIN IRON BRIDGE COMPANY, BERLIN, CT) From 'Bridge Street Bridge', photographer and date unknown. - Notre Dame Bridge, Spanning Merrimack River on Bridge Street, Manchester, Hillsborough County, NH

Use and selection of bridges as day roosts by Rafinesque's Big Eared Bats.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bennett, Frances, M.; Loeb, Susan, C.; Bunch, Mary, S.

ABSTRACT.—Rafinesque’s big-eared bats (Corynorhinus rafinesquii) use bridges as day roosts in parts of their range, but information on bridge use across their range is lacking. From May to Aug. 2002 we surveyed 1129 bridges (12.5%) within all 46 counties of South Carolina to determine use and selection of bridges as day roosts by big-eared bats and to document their distribution across the state. During summer 2003, we visited 235 bridges in previously occupied areas of the state to evaluate short-term fidelity to bridge roosts. We found colonies and solitary big-eared bats beneath 38 bridges in 2002 and 54 bridges inmore » 2003. Construction type and size of bridges strongly influenced use in both years; bats selected large, concrete girder bridges and avoided flat-bottomed slab bridges. The majority of occupied bridges (94.7%) were in the Upper and Lower Coastal Plains, but a few bridges (5.3%) were located in the Piedmont. Rafinesque’s big-eared bats were absent beneath bridges in the Blue Ridge Mountains. We established new records of occurrence for 10 counties. In the Coastal Plains, big-eared bats exhibited a high degree of short-term fidelity to roosts in highway bridges. For bridges that were occupied at least once, mean frequency of use was 65.9%. Probability of finding bats under a bridge ranged from 0.46 to 0.73 depending on whether the bridge was occupied in the previous year. Thus, bridges should be inspected three to five times in a given year to determine whether they are being used. Regional bridge roost surveys may be a good method for determining the distribution of C. rafinesquii, particularly in the Coastal Plains, and protection of suitable bridges may be a viable conservation strategy where natural roost sites are limited.« less

23 CFR 650.409 - Evaluation of bridge inventory.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 23 Highways 1 2011-04-01 2011-04-01 false Evaluation of bridge inventory. 650.409 Section 650.409... BRIDGES, STRUCTURES, AND HYDRAULICS Highway Bridge Replacement and Rehabilitation Program § 650.409 Evaluation of bridge inventory. (a) Sufficiency rating of bridges. Upon receipt and evaluation of the bridge...

49 CFR 237.109 - Bridge inspection records.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 4 2011-10-01 2011-10-01 false Bridge inspection records. 237.109 Section 237.109..., DEPARTMENT OF TRANSPORTATION BRIDGE SAFETY STANDARDS Bridge Inspection § 237.109 Bridge inspection records... performed on those bridges under this part. (b) Each record of an inspection under the bridge management...

33 CFR 115.70 - Advance approval of bridges.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Advance approval of bridges. 115... BRIDGES BRIDGE LOCATIONS AND CLEARANCES; ADMINISTRATIVE PROCEDURES § 115.70 Advance approval of bridges. (a) The General Bridge Act of 1946 requires the approval of the location and plans of bridges prior...

23 CFR 650.409 - Evaluation of bridge inventory.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 23 Highways 1 2010-04-01 2010-04-01 false Evaluation of bridge inventory. 650.409 Section 650.409... BRIDGES, STRUCTURES, AND HYDRAULICS Highway Bridge Replacement and Rehabilitation Program § 650.409 Evaluation of bridge inventory. (a) Sufficiency rating of bridges. Upon receipt and evaluation of the bridge...

49 CFR 237.109 - Bridge inspection records.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Bridge inspection records. 237.109 Section 237.109..., DEPARTMENT OF TRANSPORTATION BRIDGE SAFETY STANDARDS Bridge Inspection § 237.109 Bridge inspection records... performed on those bridges under this part. (b) Each record of an inspection under the bridge management...

33 CFR 115.70 - Advance approval of bridges.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Advance approval of bridges. 115... BRIDGES BRIDGE LOCATIONS AND CLEARANCES; ADMINISTRATIVE PROCEDURES § 115.70 Advance approval of bridges. (a) The General Bridge Act of 1946 requires the approval of the location and plans of bridges prior...

Change in trunk muscle activities with prone bridge exercise in patients with chronic low back pain.

PubMed

Kong, Yong-Soo; Park, Seol; Kweon, Mi-Gyong; Park, Ji-Won

2016-01-01

[Purpose] The aim of this study was to determine the effect of three different bridge exercises on internal oblique, external oblique, transverse abdominis, and erector spinae activities. [Subjects and Methods] Forty-five subjects with chronic low back pain participated in this study. The training outcome was evaluated with three different testing methods: supine bridge exercise, supine bridge on Swiss ball exercise, and prone bridge exercise. The activities of the transverse abdominis, internal oblique, external oblique, and erector spinae were measured using surface electromyography. [Results] There were significant differences in the internal oblique, external oblique, and erector spinae according to the three kinds of bridging exercises. The internal oblique, external oblique and transverse abdominis activities were highest in the prone bridge exercise, followed by those in the supine bridge on Swiss ball exercise, and supine bridge exercises. The activity of erector spine was highest in the supine bridge on Swiss ball exercise followed by the supine bridge exercise and prone bridge exercise. [Conclusion] These results suggest that prone bridge exercise is more effective than conventional supine bridge exercise and supine bridge on Swiss ball in increasing trunk muscle activity of chronic low back pain patients.

33 CFR 117.718 - Elizabeth River.

Code of Federal Regulations, 2014 CFR

2014-07-01

... the South Front Street bridge, mile 0.0 at Elizabeth, shall open on signal; except that, from 12... the New Jersey Transit Rail Operations railroad bridge, mile 0.7, the Baltic Street bridge, mile 0.9, the Summer Street bridge, mile 1.3, the South Street bridge, mile 1.8, and the Bridge Street bridge...

Natural Firing Patterns Imply Low Sensitivity of Synaptic Plasticity to Spike Timing Compared with Firing Rate

PubMed Central

Wallisch, Pascal; Ostojic, Srdjan

2016-01-01

Synaptic plasticity is sensitive to the rate and the timing of presynaptic and postsynaptic action potentials. In experimental protocols inducing plasticity, the imposed spike trains are typically regular and the relative timing between every presynaptic and postsynaptic spike is fixed. This is at odds with firing patterns observed in the cortex of intact animals, where cells fire irregularly and the timing between presynaptic and postsynaptic spikes varies. To investigate synaptic changes elicited by in vivo-like firing, we used numerical simulations and mathematical analysis of synaptic plasticity models. We found that the influence of spike timing on plasticity is weaker than expected from regular stimulation protocols. Moreover, when neurons fire irregularly, synaptic changes induced by precise spike timing can be equivalently induced by a modest firing rate variation. Our findings bridge the gap between existing results on synaptic plasticity and plasticity occurring in vivo, and challenge the dominant role of spike timing in plasticity. SIGNIFICANCE STATEMENT Synaptic plasticity, the change in efficacy of connections between neurons, is thought to underlie learning and memory. The dominant paradigm posits that the precise timing of neural action potentials (APs) is central for plasticity induction. This concept is based on experiments using highly regular and stereotyped patterns of APs, in stark contrast with natural neuronal activity. Using synaptic plasticity models, we investigated how irregular, in vivo-like activity shapes synaptic plasticity. We found that synaptic changes induced by precise timing of APs are much weaker than suggested by regular stimulation protocols, and can be equivalently induced by modest variations of the AP rate alone. Our results call into question the dominant role of precise AP timing for plasticity in natural conditions. PMID:27807166

Guardrails for use on historic bridges : volume 1--replacement strategies.

DOT National Transportation Integrated Search

2016-11-01

Bridges that are designated historic present a special challenge to bridge engineers whenever rehabilitation work or improvements are : made to the bridges. Federal and state laws protect historically significant bridges, and railings on these bridge...

OVERVIEW OF BRIDGES WITH WAIKELE CANAL BRIDGE IN CENTER, OR&L ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

OVERVIEW OF BRIDGES WITH WAIKELE CANAL BRIDGE IN CENTER, OR&L BRIDGE IN BACKGROUND. SHOWING THE EARTHEN INCLINE THAT RAISES FARRINGTON HIGHWAY OVER THE FORMER OR&L TRACKS. NOTE THE 1963 WESTBOUND BRIDGE IN THE FOREGROUND. VIEW FACING EAST. - Waikele Canal Bridge and Highway Overpass, Farrington Highway and Waikele Stream, Waipahu, Honolulu County, HI

Comprehensive evaluation of fracture critical bridges.

DOT National Transportation Integrated Search

2014-02-01

Two-girder steel bridges are classified as fracture critical bridges based on the definition given in the AASHTO LRFD Bridge Design Specifications. In a fracture critical bridge a failure of a tension member leads to collapse of the bridge. However, ...

Toll bridge report to the California legislature, FY 2001 - 02

DOT National Transportation Integrated Search

2002-01-01

In the San Francisco Bay Area, eight toll bridges serve as essential transportation arteries for the traveling public. Seven of the bridges are state-owned: the Antioch Bridge, the Benicia-Martinez Bridge, the Carquinez Bridge, the Richmond-San Rafae...

28. BRIDGE NO. 9 APRON AND BRIDGE HINGE JOINT AND ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

28. BRIDGE NO. 9 APRON AND BRIDGE HINGE JOINT AND BRIDGE SUSPENSION SYSTEM SHOWING EYEBAR AND CABLE CONNECTIONS. LOOKING WEST. - Greenville Yard, Transfer Bridge System, Port of New York/New Jersey, Upper New York Bay, Jersey City, Hudson County, NJ

Building Better Bridges into STEM: A Synthesis of 25 Years of Literature on STEM Summer Bridge Programs

PubMed Central

Ashley, Michael; Cooper, Katelyn M.; Cala, Jacqueline M.; Brownell, Sara E.

2017-01-01

Summer bridge programs are designed to help transition students into the college learning environment. Increasingly, bridge programs are being developed in science, technology, engineering, and mathematics (STEM) disciplines because of the rigorous content and lower student persistence in college STEM compared with other disciplines. However, to our knowledge, a comprehensive review of STEM summer bridge programs does not exist. To provide a resource for bridge program developers, we conducted a systematic review of the literature on STEM summer bridge programs. We identified 46 published reports on 30 unique STEM bridge programs that have been published over the past 25 years. In this review, we report the goals of each bridge program and whether the program was successful in meeting these goals. We identify 14 distinct bridge program goals that can be organized into three categories: academic success goals, psychosocial goals, and department-level goals. Building on the findings of published bridge reports, we present a set of recommendations for STEM bridge programs in hopes of developing better bridges into college. PMID:29146667

49 CFR 237.103 - Bridge inspection procedures.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 4 2011-10-01 2011-10-01 false Bridge inspection procedures. 237.103 Section 237... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION BRIDGE SAFETY STANDARDS Bridge Inspection § 237.103 Bridge inspection procedures. (a) Each bridge management program shall specify the procedure to be used for...

23 CFR 650.809 - Movable span bridges.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 23 Highways 1 2011-04-01 2011-04-01 false Movable span bridges. 650.809 Section 650.809 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS BRIDGES, STRUCTURES, AND HYDRAULICS Navigational Clearances for Bridges § 650.809 Movable span bridges. A fixed bridge...

33 CFR 115.50 - Application for bridge permits.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Application for bridge permits... BRIDGES BRIDGE LOCATIONS AND CLEARANCES; ADMINISTRATIVE PROCEDURES § 115.50 Application for bridge permits. (a) Application. An application for authorization to construct a bridge across navigable waters of...

49 CFR 237.101 - Scheduling of bridge inspections.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 4 2011-10-01 2011-10-01 false Scheduling of bridge inspections. 237.101 Section... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION BRIDGE SAFETY STANDARDS Bridge Inspection § 237.101 Scheduling of bridge inspections. (a) Each bridge management program shall include a provision for scheduling an...

29. BRIDGE NO. 13 APRON AND BRIDGE HINGE JOINT AND ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

29. BRIDGE NO. 13 APRON AND BRIDGE HINGE JOINT AND BRIDGE SUSPENSION SYSTEM (OLDER STYLE) SHOWING EYEBAR AND CABLE CONNECTIONS. LOOKING WEST. - Greenville Yard, Transfer Bridge System, Port of New York/New Jersey, Upper New York Bay, Jersey City, Hudson County, NJ

5. View of Clark Fork Vehicle Bridge facing east. Bridge ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. View of Clark Fork Vehicle Bridge facing east. Bridge from south shore of Clark Fork River-southernmost span. 1900-era Northern Pacific Railway Bridge in background. - Clark Fork Vehicle Bridge, Spanning Clark Fork River, serves Highway 200, Clark Fork, Bonner County, ID

Temperature differential of swingspan bridges : final report.

DOT National Transportation Integrated Search

1969-06-01

This report describes a study performed to determine the temperature differential of the top and bottom member of one side of a swingspan bridge. Three bridges were used in the study. Bridge No. 1 was an equal-arm swingspan bridge, Bridge No. 2 was a...

49 CFR 237.101 - Scheduling of bridge inspections.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Scheduling of bridge inspections. 237.101 Section... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION BRIDGE SAFETY STANDARDS Bridge Inspection § 237.101 Scheduling of bridge inspections. (a) Each bridge management program shall include a provision for scheduling an...

23 CFR 650.809 - Movable span bridges.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 23 Highways 1 2010-04-01 2010-04-01 false Movable span bridges. 650.809 Section 650.809 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS BRIDGES, STRUCTURES, AND HYDRAULICS Navigational Clearances for Bridges § 650.809 Movable span bridges. A fixed bridge...

49 CFR 237.103 - Bridge inspection procedures.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Bridge inspection procedures. 237.103 Section 237... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION BRIDGE SAFETY STANDARDS Bridge Inspection § 237.103 Bridge inspection procedures. (a) Each bridge management program shall specify the procedure to be used for...

New conceptual design of portable bamboo bridge for emergency purposes

NASA Astrophysics Data System (ADS)

Musthaffa, A. A.; Nor, N. M.; Yusof, M. A.; Yuhazri, M. Y.

2018-02-01

Portable bridges serve as routes for troops during the military operations and the disaster relief operation. Nowadays, bamboo has been regarded as one of the alternative construction materials for building and bridge structures. This paper presents the conceptual design of the portable bridge. Several types of portable bridges and bamboo bridges are reviewed in the current work. The characteristics, capability and method of construction of each bridge are discussed. Finally, the conceptual of the portable bamboo bridge for emergency purposes is presented. The idea of producing portable bridge is proposed in the current work as it is crucial for providing route for communities affected by natural disasters.

33 CFR 115.40 - Bridge repairs.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Bridge repairs. 115.40 Section 115.40 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES BRIDGE LOCATIONS AND CLEARANCES; ADMINISTRATIVE PROCEDURES § 115.40 Bridge repairs. Repairs to a bridge which do...

49 CFR 237.33 - Content of bridge management programs.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 4 2011-10-01 2011-10-01 false Content of bridge management programs. 237.33... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION BRIDGE SAFETY STANDARDS Railroad Bridge Safety Assurance § 237.33 Content of bridge management programs. Each bridge management program adopted in compliance with this part...

23 CFR 650.307 - Bridge inspection organization.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 23 Highways 1 2011-04-01 2011-04-01 false Bridge inspection organization. 650.307 Section 650.307... BRIDGES, STRUCTURES, AND HYDRAULICS National Bridge Inspection Standards § 650.307 Bridge inspection... bridges located on public roads that are fully or partially located within the State's boundaries, except...

33 CFR 118.90 - Bridges crossing channel obliquely.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Bridges crossing channel obliquely. 118.90 Section 118.90 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES BRIDGE LIGHTING AND OTHER SIGNALS § 118.90 Bridges crossing channel obliquely. Bridges...

49 CFR 237.107 - Conduct of bridge inspections.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 4 2011-10-01 2011-10-01 false Conduct of bridge inspections. 237.107 Section 237... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION BRIDGE SAFETY STANDARDS Bridge Inspection § 237.107 Conduct of bridge inspections. Bridge inspections shall be conducted under the direct supervision of a designated...

Live load monitoring for the I-10 twin span bridge : research project capsule.

DOT National Transportation Integrated Search

2014-10-01

To establish a site-specific database for bridge evaluation and future bridge design, : DOTD established a long-term health monitoring system at the I-10 Twin Span Bridge. : The bridge is instrumented from deck to piles to capture bridge response (bo...

33 CFR 115.40 - Bridge repairs.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Bridge repairs. 115.40 Section 115.40 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES BRIDGE LOCATIONS AND CLEARANCES; ADMINISTRATIVE PROCEDURES § 115.40 Bridge repairs. Repairs to a bridge which do...

33 CFR 118.90 - Bridges crossing channel obliquely.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Bridges crossing channel obliquely. 118.90 Section 118.90 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES BRIDGE LIGHTING AND OTHER SIGNALS § 118.90 Bridges crossing channel obliquely. Bridges...

49 CFR 237.33 - Content of bridge management programs.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Content of bridge management programs. 237.33... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION BRIDGE SAFETY STANDARDS Railroad Bridge Safety Assurance § 237.33 Content of bridge management programs. Each bridge management program adopted in compliance with this part...

49 CFR 237.107 - Conduct of bridge inspections.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Conduct of bridge inspections. 237.107 Section 237... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION BRIDGE SAFETY STANDARDS Bridge Inspection § 237.107 Conduct of bridge inspections. Bridge inspections shall be conducted under the direct supervision of a designated...

33 CFR 115.50 - Application for bridge permits.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Application for bridge permits... BRIDGES BRIDGE LOCATIONS AND CLEARANCES; ADMINISTRATIVE PROCEDURES § 115.50 Application for bridge permits. (a) Approval of plans. An application for authorization to construct a bridge across navigable waters...

Bridged graphite oxide materials

NASA Technical Reports Server (NTRS)

Herrera-Alonso, Margarita (Inventor); McAllister, Michael J. (Inventor); Aksay, Ilhan A. (Inventor); Prud'homme, Robert K. (Inventor)

2010-01-01

Bridged graphite oxide material comprising graphite sheets bridged by at least one diamine bridging group. The bridged graphite oxide material may be incorporated in polymer composites or used in adsorption media.

Chitosan/silk fibroin-based, Schwann cell-derived extracellular matrix-modified scaffolds for bridging rat sciatic nerve gaps.

PubMed

Gu, Yun; Zhu, Jianbin; Xue, Chengbin; Li, Zhenmeiyu; Ding, Fei; Yang, Yumin; Gu, Xiaosong

2014-02-01

Extracellular matrix (ECM) plays a prominent role in establishing and maintaining an ideal microenvironment for tissue regeneration, and ECM scaffolds are used as a feasible alternative to cellular and molecular therapy in the fields of tissue engineering. Because of their advantages over tissue-derived ECM scaffolds, cultured cell-derived ECM scaffolds are beginning to attract attention, but they have been scarcely studied for peripheral nerve repair. Here we aimed to develop a tissue engineered nerve scaffold by reconstituting nerve cell-derived ECM with natural biomaterials. A protocol was adopted to prepare and characterize the cultured Schwann cell (SC)-derived ECM. A chitosan conduit and silk fibroin (SF) fibers were prepared, cultured with SCs for ECM deposition, and subjected to decellularization, followed by assembly into a chitosan/SF-based, SC-derived ECM-modified scaffold, which was used to bridge a 10 mm rat sciatic nerve gap. The results from morphological analysis as well as electrophysiological examination indicated that regenerative outcomes achieved by our developed scaffold were similar to those by an acellular nerve graft (namely a nerve tissue-derived ECM scaffold), but superior to those by a plain chitosan/SF scaffold. Moreover, blood and histopathological parameters confirmed the safety of scaffold modification by SC-derived ECM. Therefore, a hybrid scaffold based on joint use of acellular and classical biomaterials represents a promising approach to nerve tissue engineering. Copyright © 2013 Elsevier Ltd. All rights reserved.

Development of a real-time bridge structural monitoring and warning system: a case study in Thailand

NASA Astrophysics Data System (ADS)

Khemapech, I.; Sansrimahachai, W.; Toachoodee, M.

2017-04-01

Regarded as one of the physical aspects under societal and civil development and evolution, engineering structure is required to support growth of the nation. It also impacts life quality and safety of the civilian. Despite of its own weight (dead load) and live load, structural members are also significantly affected by disaster and environment. Proper inspection and detection are thus crucial both during regular and unsafe events. An Enhanced Structural Health Monitoring System Using Stream Processing and Artificial Neural Network Techniques (SPANNeT) has been developed and is described in this paper. SPANNeT applies wireless sensor network, real-time data stream processing and artificial neural network based upon the measured bending strains. Major contributions include an effective, accurate and energy-aware data communication and damage detection of the engineering structure. Strain thresholds have been defined according to computer simulation results and the AASHTO (American Association of State Highway and Transportation Officials) LRFD (Load and Resistance Factor Design) Bridge Design specifications for launching several warning levels. SPANNeT has been tested and evaluated by means of computer-based simulation and on-site levels. According to the measurements, the observed maximum values are 25 to 30 microstrains during normal operation. The given protocol provided at least 90% of data communication reliability. SPANNeT is capable of real-time data report, monitoring and warning efficiently conforming to the predefined thresholds which can be adjusted regarding user's requirements and structural engineering characteristics.

Acute-on-chronic Liver Failure.

PubMed

Sarin, Shiv Kumar; Choudhury, Ashok

2016-12-01

Acute-on-chronic liver failure (ACLF) is a distinct entity that differs from acute liver failure and decompensated cirrhosis in timing, presence of treatable acute precipitant, and course of disease, with a potential for self-recovery. The core concept is acute deterioration of existing liver function in a patient of chronic liver disease with or without cirrhosis in response to an acute insult. The insult should be a hepatic one and presentation in the form of liver failure (jaundice, encephalopathy, coagulopathy, ascites) with or without extrahepatic organ failure in a defined time frame. ACLF is characterized by a state of deregulated inflammation. Initial cytokine burst presenting as SIRS, progression to CARS and associated immunoparalysis leads to sepsis and multi-organ failure. Early identification of the acute insult and mitigation of the same, use of nucleoside analogue in HBV-ACLF, steroid in severe alcoholic hepatitis, steroid in severe autoimmune hepatitis and/or bridging therapy lead to recovery, with a 90-day transplant-free survival rate of up to 50 %. First-week presentation is crucial concerning SIRS/sepsis, development, multiorgan failure and consideration of transplant. A protocol-based multi-disciplinary approach including critical care hepatology, early liver transplant before multi-organ involvement, or priority for organ allocation may improve the outcome. Presentation with extrahepatic organ involvement or inclusion of sepsis as an acute insult in definition restricts the therapy, i.e., liver transplant or bridging therapy, and needs serious consideration. Augmentation of regeneration, cell-based therapy, immunotherapy, and gut microbiota modulation are the emerging areas and need further research.

Stability and Marginal Bone Level Changes of SLActive Titanium-Zirconium Implants Placed with Flapless Surgery: A Prospective Pilot Study.

PubMed

Altinci, Pinar; Can, Gulsen; Gunes, Onur; Ozturk, Caner; Eren, Hakan

2016-12-01

Immediately-loaded, narrow-diameter implants can be a less invasive alternative for the implant-supported fixed rehabilitation of narrow, posterior crests. To determine the stability and marginal bone level (MBL) changes of narrow-diameter, titanium-zirconium (TiZr) implants placed with flapless surgery and loaded immediately in the posterior region. Thirty-eight TiZr implants (3.3 mm diameter, 10 mm length, Roxolid, Straumann AG) were placed in the posterior crests of 14 patients with computer-guided flapless surgery as a support of 3-unit posterior bridges. Eighteen implants were loaded immediately, and 20 implants were loaded conventionally. The implant stability quotients were determined at the 1, 2, 4, and 8. weeks of healing before conventional loading, and at the 3, 6, and 12. months after loading by resonance frequency analysis. The MBL changes were measured by digital radiography. The surgical protocols were accomplished without any biological complications. There was no significant difference in the stability changes of TiZr implants between the loading groups (p > .05). The MBL changes were -0.18 ± 0.27 mm and -0.24 ± 0.27 mm at the 12. month of immediate and conventional loading, respectively, which was not statistically significant (p > .05). The stability and MBL changes of TiZr implants supporting posterior 3-unit bridges were clinically acceptable at the first year of loading. © 2016 Wiley Periodicals, Inc.

1. View of bridge from Interstate 195 (Washington Bridge) looking ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. View of bridge from Interstate 195 (Washington Bridge) looking southwest - India Point Railroad Bridge, Spanning Seekonk River between Providence & East Providence, Providence, Providence County, RI

33 CFR 118.110 - Daymarks and lateral lighting on bridges.

Code of Federal Regulations, 2011 CFR

2011-07-01

... bridges. 118.110 Section 118.110 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES BRIDGE LIGHTING AND OTHER SIGNALS § 118.110 Daymarks and lateral lighting on bridges. (a... through bridges with U.S. aids to navigation system lateral marks and lights installed on the...

49 CFR 237.31 - Adoption of bridge management programs.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 4 2011-10-01 2011-10-01 false Adoption of bridge management programs. 237.31... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION BRIDGE SAFETY STANDARDS Railroad Bridge Safety Assurance § 237.31 Adoption of bridge management programs. Each track owner shall adopt a bridge safety management program to...

Phase I of roadmap towards incorporating intelligent structure technology for refining bridge inspection in Mississippi.

DOT National Transportation Integrated Search

2011-02-25

"Bridge scour refers to the removal of sediments from the bridge foundation by flood. It is the most detrimental cause for the majority of : bridge failures in the United States. In the National Bridge Registry, there are 484,546 highway bridges over...

33 CFR 118.110 - Daymarks and lateral lighting on bridges.

Code of Federal Regulations, 2010 CFR

2010-07-01

... bridges. 118.110 Section 118.110 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES BRIDGE LIGHTING AND OTHER SIGNALS § 118.110 Daymarks and lateral lighting on bridges. (a... through bridges with U.S. aids to navigation system lateral marks and lights installed on the...

49 CFR 237.31 - Adoption of bridge management programs.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Adoption of bridge management programs. 237.31... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION BRIDGE SAFETY STANDARDS Railroad Bridge Safety Assurance § 237.31 Adoption of bridge management programs. Each track owner shall adopt a bridge safety management program to...

Laboratory and field testing of an accelerated bridge construction demonstration bridge : US Highway 6 bridge over Keg Creek.

DOT National Transportation Integrated Search

2013-04-01

The US Highway 6 Bridge over Keg Creek outside of Council Bluffs, Iowa is a demonstration bridge site chosen to put into practice : newly-developed Accelerated Bridge Construction (ABC) concepts. One of these new concepts is the use of prefabricated ...

OVERVIEW OF BRIDGES WITH OR&L BRIDGE IN CENTER, WAIKELE CANAL ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

OVERVIEW OF BRIDGES WITH OR&L BRIDGE IN CENTER, WAIKELE CANAL BRIDGE IN BACKGROUND. SHOWING THE EARTHEN INCLINE THAT RAISES FARRINGTON HIGHWAY OVER THE FORMER OR&L TRACKS. VIEW FACING SOUTHWEST. - Waikele Canal Bridge and Highway Overpass, Farrington Highway and Waikele Stream, Waipahu, Honolulu County, HI

Field performance of timber bridges. 4, Graves Crossing stress-laminated deck bridge

Treesearch

J. P. Wacker; M. A. Ritter

The Graves Crossing bridge was constructed October 1991 in Antrim County, Michigan, as part of the demonstration timber bridge program sponsored by the USDA Forest Service. The bridge is a two-span continuous, stress-laminated deck superstructure and it is 36-ft long and 26-ft wide. The bridge is one of the first stress-laminated deck bridges to be built of sawn lumber...

Bridges in complex networks

NASA Astrophysics Data System (ADS)

Wu, Ang-Kun; Tian, Liang; Liu, Yang-Yu

2018-01-01

A bridge in a graph is an edge whose removal disconnects the graph and increases the number of connected components. We calculate the fraction of bridges in a wide range of real-world networks and their randomized counterparts. We find that real networks typically have more bridges than their completely randomized counterparts, but they have a fraction of bridges that is very similar to their degree-preserving randomizations. We define an edge centrality measure, called bridgeness, to quantify the importance of a bridge in damaging a network. We find that certain real networks have a very large average and variance of bridgeness compared to their degree-preserving randomizations and other real networks. Finally, we offer an analytical framework to calculate the bridge fraction and the average and variance of bridgeness for uncorrelated random networks with arbitrary degree distributions.

A study on carbon nanotube bridge as a electromechanical memory device

NASA Astrophysics Data System (ADS)

Kang, Jeong Won; Ha Lee, Jun; Joo Lee, Hoong; Hwang, Ho Jung

2005-04-01

A nanoelectromechanical (NEM) nanotube random access memory (NRAM) device based on carbon nanotube (CNT) was investigated using atomistic simulations. For the CNT-based NEM memory, the mechanical properties of the CNT-bridge and van der Waals interactions between the CNT-bridge and substrate were very important. The critical amplitude of the CNT-bridge was 16% of the length of the CNT-bridge. As molecular dynamics time increased, the CNT-bridge went to the steady state under the electrostatic force with the damping of the potential and the kinetic energies of the CNT-bridge. The interatomic interaction between the CNT-bridge and substrate, value of the CNT-bridge slack, and damping rate of the CNT-bridge were very important for the operation of the NEM memory device as a nonvolatile memory.

Bridge Frost Prediction by Heat and Mass Transfer Methods

NASA Astrophysics Data System (ADS)

Greenfield, Tina M.; Takle, Eugene S.

2006-03-01

Frost on roadways and bridges can present hazardous conditions to motorists, particularly when it occurs in patches or on bridges when adjacent roadways are clear of frost. To minimize materials costs, vehicle corrosion, and negative environmental impacts, frost-suppression chemicals should be applied only when, where, and in the appropriate amounts needed to maintain roadways in a safe condition for motorists. Accurate forecasts of frost onset times, frost intensity, and frost disappearance (e.g., melting or sublimation) are needed to help roadway maintenance personnel decide when, where, and how much frost-suppression chemical to use. A finite-difference algorithm (BridgeT) has been developed that simulates vertical heat transfer in a bridge based on evolving meteorological conditions at its top and bottom as supplied by a weather forecast model. BridgeT simulates bridge temperatures at numerous points within the bridge (including its upper and lower surface) at each time step of the weather forecast model and calculates volume per unit area (i.e., depth) of deposited, melted, or sublimed frost. This model produces forecasts of bridge surface temperature, frost depth, and bridge condition (i.e., dry, wet, icy/snowy). Bridge frost predictions and bridge surface temperature are compared with observed and measured values to assess BridgeT's skill in forecasting bridge frost and associated conditions.

Improving bridge load rating accuracy.

DOT National Transportation Integrated Search

2013-06-01

Nearly one-quarter of Alabamas bridges are deemed structurally deficient or functionally obsolete. An : additional seven percent of Alabamas bridges were posted bridges in 2010. (Federal Highway Administration, : 2011) Accurate bridge load rati...

Myocardial Bridge

MedlinePlus

... Center > Myocardial Bridge Menu Topics Topics FAQs Myocardial Bridge En español Your heart is made of muscle, ... surface of the heart. What is a myocardial bridge? A myocardial bridge is a band of heart ...

GOETHALS BRIDGE FROM NORTH SIDE OVER ARTHUR KILL. RAILROAD BRIDGE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

GOETHALS BRIDGE FROM NORTH SIDE OVER ARTHUR KILL. RAILROAD BRIDGE IN FOREGROUND - Goethals Bridge, Spanning Arthur Kill from New Jersey to Staten Island, Staten Island (subdivision), Richmond County, NY

25 CFR 170.506 - What are the minimum qualifications for certified bridge inspectors?

Code of Federal Regulations, 2011 CFR

2011-04-01

... 25 Indians 1 2011-04-01 2011-04-01 false What are the minimum qualifications for certified bridge... Program Facilities Bridge Inspection § 170.506 What are the minimum qualifications for certified bridge inspectors? The person responsible for the bridge inspection team must meet the qualifications for bridge...

33 CFR 117.647 - Saginaw River.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Lake State Railway Bridge, mile 3.10, and the Canadian National Railway Bridge, mile 4.94, both in Bay... if at least 12 hours advance notice is provided. (b) The draws of the Independence Bridge, mile 3.88, Liberty Street Bridge, mile 4.99, Veterans Memorial Bridge, mile 5.60, and Lafayette Street Bridge, mile 6...

33 CFR 117.647 - Saginaw River.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Lake State Railway Bridge, mile 3.10, and the Canadian National Railway Bridge, mile 4.94, both in Bay... if at least 12 hours advance notice is provided. (b) The draws of the Independence Bridge, mile 3.88, Liberty Street Bridge, mile 4.99, Veterans Memorial Bridge, mile 5.60, and Lafayette Street Bridge, mile 6...

33 CFR 117.647 - Saginaw River.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Lake State Railway Bridge, mile 3.10, and the Canadian National Railway Bridge, mile 4.94, both in Bay... if at least 12 hours advance notice is provided. (b) The draws of the Independence Bridge, mile 3.88, Liberty Street Bridge, mile 4.99, Veterans Memorial Bridge, mile 5.60, and Lafayette Street Bridge, mile 6...

33 CFR 118.85 - Lights on vertical lift bridges.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Lights on vertical lift bridges... BRIDGES BRIDGE LIGHTING AND OTHER SIGNALS § 118.85 Lights on vertical lift bridges. (a) Lift span lights. The vertical lift span of every vertical lift bridge shall be lighted so that the center of the...

33 CFR 118.85 - Lights on vertical lift bridges.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Lights on vertical lift bridges... BRIDGES BRIDGE LIGHTING AND OTHER SIGNALS § 118.85 Lights on vertical lift bridges. (a) Lift span lights. The vertical lift span of every vertical lift bridge shall be lighted so that the center of the...

3. CONTEXTUAL VIEW OF BRIDGE IN SETTING, LOOKING SOUTHWEST FROM ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. CONTEXTUAL VIEW OF BRIDGE IN SETTING, LOOKING SOUTHWEST FROM ELEVATED GRADE OF EUREKA SOUTHERN RAILROAD. EUREKA SOUTHERN TRUSS BRIDGE AT EXTREME LEFT, 1924 HIGHWAY BRIDGE IN CENTER, 1952 HIGHWAY BRIDGE AT RIGHT - Van Duzen River Bridge, Spanning Van Duzen River at CA State Highway 101, Alton, Humboldt County, CA

33 CFR 118.65 - Lights on fixed bridges.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Lights on fixed bridges. 118.65 Section 118.65 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES BRIDGE LIGHTING AND OTHER SIGNALS § 118.65 Lights on fixed bridges. (a) Each fixed bridge span over a navigable...

33 CFR 118.70 - Lights on swing bridges.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Lights on swing bridges. 118.70 Section 118.70 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES BRIDGE LIGHTING AND OTHER SIGNALS § 118.70 Lights on swing bridges. (a) Swing span lights on through bridges. Each...

Study on the Old Girders in the Widening Hollow Slab Girder Bridge

NASA Astrophysics Data System (ADS)

Wang, Ying; Zhang, Li Fang; Ma, Hai Yan

2018-06-01

Taking the bridge widening project of Shanghai-Hangzhou-Ningbo expressway widening construction project (China) as the background in this paper, the variation law of the internal force of the old bridge in the widening hollow slab girder bridge under vehicle load is studied, which is under the condition of different span lengths and different widening widths. Three different span lengths of the pre-tensioned prestressed hollow slab girder bridges are selected, the spatial finite element models of both the old bridge and the whole structure of widening bridge are established and calculated respectively by Midas/Civil software. The influences of widening and load increasing on the old bridges under the vehicle load are compared and analyzed. In addition, the authors also analyze the influences of different widening widths on the force state of old bridges under the condition of widening the same number of lane. Moreover , the effects on the old bridges that are caused by the uneven foundation settlement of widening bridge structure are also studied in this paper. This paper can provide some references for widening design of hollow slab bridges.

LOOKING WEST, BETWEEN READING DEPOT BRIDGE AND SKEW ARCH BRIDGE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

LOOKING WEST, BETWEEN READING DEPOT BRIDGE AND SKEW ARCH BRIDGE (HAER No. PA-116). - Philadelphia & Reading Railroad, Reading Depot Bridge, North Sixth Street at Woodward Street, Reading, Berks County, PA

1. VIEW OF SWING BRIDGE FROM KEDZIE AVENUE BRIDGE, LOOKING ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. VIEW OF SWING BRIDGE FROM KEDZIE AVENUE BRIDGE, LOOKING EAST. - Chicago, Madison & Northern Railroad, Sanitary & Ship Canal Bridge, Spanning Sanitary & Ship Canal, east of Kedzie Avenue, Chicago, Cook County, IL

Plans: Poop Deck, Boat Deck, Housetop, Bridge Deck, Upper Bridge ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Plans: Poop Deck, Boat Deck, Housetop, Bridge Deck, Upper Bridge Deck, Navigating Bridge, Forecastle Deck, Upper Deck, Second Deck and Hold - Saugatuck, James River Reserve Fleet, Newport News, Newport News, VA

Coupling vibration research on Vehicle-bridge system

NASA Astrophysics Data System (ADS)

Zhou, Jiguo; Wang, Guihua

2018-01-01

The vehicle-bridge coupling system forms when vehicle running on a bridge. It will generate a relatively large influence on the driving comfort and driving safe when the vibration of the vehicle is bigger. A three-dimensional vehicle-bridge system with biaxial seven degrees of freedom has been establish in this paper based on finite numerical simulation. Adopting the finite element transient numerical simulation to realize the numerical simulation of vehicle-bridge system coupling vibration. Then, analyze the dynamic response of vehicle and bridge while different numbers of vehicles running on the bridge. Got the variation rule of vertical vibration of car body and bridge, and that of the contact force between the wheel and bridge deck. The research results have a reference value for the analysis about the vehicle running on a large-span cabled bridge.

Myocardial bridges of the coronary arteries in the human fetal heart.

PubMed

Cakmak, Yusuf Ozgür; Cavdar, Safiye; Yalin, Aymelek; Yener, Nuran; Ozdogmus, Omer

2010-09-01

During the last century, many investigators reported on myocardial bridges in the adult human heart. In the present study, 39 human fetal hearts (the mean gestastional age was 30 weeks) were studied for myocardial bridging, and the results were correlated with adult data. Among the 39 (27 male and 12 female) fetal hearts studied, 26 bridges were observed on 18 fetal hearts (46.2%). Ten of the bridges had one myocardial bridge, whereas double myocardial bridges were observed in eight fetal hearts. The most frequent myocardial bridges were observed on the left anterior descending artery (LAD), which had 13 bridges (50%). Eight (30.7%) myocardial bridges were on the diagonal artery, and on the posterior descending artery there were five (19.3%). Myocardial bridges were not observed on the circumflex artery. The data presented in this study may provide potentially useful information for the preoperative evaluation of the newborn and may have a clinical implication for sudden fetal death.

A 12-year National Study of Suicide by Jumping From Bridges in Norway.

PubMed

Sæheim, Aleksandra; Hestetun, Ingebjørg; Mork, Erlend; Nrugham, Latha; Mehlum, Lars

2017-01-01

Studies from several countries suggest that erecting fences on bridges more commonly used for suicide by jumping may be an effective way of reducing the risk of suicide by jumping from these bridges. Distribution of suicides by jumping off bridges has not yet been studied on a national level in any country. This study included all suicides by jumping from high places registered in the Norwegian Cause of Death Registry (COD) in the period 1999-2010 (n = 319). Combining data from the COD registry and information from police records, 71 cases of suicide by jumping off a bridge were identified involving 36 bridges. This form of suicide constituted approximately 1% of all suicides in Norway in the period 1999-2010. Almost half of these suicides were registered at only 6 bridges. Three Norwegian bridges were secured during the observation period of this study. Two bridges had barriers installed on the full length of the bridge with 11 suicides registered before barriers were installed, and none after. On the 1 bridge that was only partially secured, no change in numbers of suicides was observed after barriers were installed. One-third of jumps from bridges occurred over land. We found that although suicide by jumping off bridges was a relatively rare event, there is a potential for saving lives by installing physical barriers on bridges that are more commonly used for suicide by jumping.

Synthesis of Diverse Nitrogen-Enriched Heterocyclic Scaffolds Using a Suite of Tunable One-Pot Multicomponent Reactions

PubMed Central

2015-01-01

Five elegant and switchable three-component reactions which enable access to a new series of nitrogen-containing heterocycles are reported. A novel one-step addition of an isocyanide to a hydrazine derived Schiff base affords unique six-membered pyridotriazine scaffolds (A and E). With slight modification of reaction conditions and replacement of the nucleophilic isocyanide moiety with different electrophiles (i.e., isocyanates, isothiocyanates, cyclic anhydrides, and acyl chlorides) five-membered triazolopyridine scaffolds (B, D, F, G) are generated in a single step. Furthermore, the use of phenyl hydrazine enables access to dihydroindazole-carboxamides, devoid of a bridge-head nitrogen (C). All protocols are robust and tolerate a diverse collection of reactants, and as such, it is expected that the new scaffolds and associated chemistry will garner high interest from medicinal chemists involved in either file enhancement or specific target-related drug discovery campaigns. PMID:24788091

Joining the quantum state of two photons into one

NASA Astrophysics Data System (ADS)

Vitelli, Chiara; Spagnolo, Nicolò; Aparo, Lorenzo; Sciarrino, Fabio; Santamato, Enrico; Marrucci, Lorenzo

2013-07-01

Photons are the ideal carriers of quantum information for communication. Each photon can have a single or multiple qubits encoded in its internal quantum state, as defined by optical degrees of freedom such as polarization, wavelength, transverse modes and so on. However, as photons do not interact, multiplexing and demultiplexing the quantum information across photons has not been possible hitherto. Here, we introduce and demonstrate experimentally a physical process, named `quantum joining', in which the two-dimensional quantum states (qubits) of two input photons are combined into a single output photon, within a four-dimensional Hilbert space. The inverse process is also proposed, in which the four-dimensional quantum state of a single photon is split into two photons, each carrying a qubit. Both processes can be iterated, and hence provide a flexible quantum interconnect to bridge multiparticle protocols of quantum information with multidegree-of-freedom ones, with possible applications in future quantum networking.

Data standards for clinical research data collection forms: current status and challenges.

PubMed

Richesson, Rachel L; Nadkarni, Prakash

2011-05-01

Case report forms (CRFs) are used for structured-data collection in clinical research studies. Existing CRF-related standards encompass structural features of forms and data items, content standards, and specifications for using terminologies. This paper reviews existing standards and discusses their current limitations. Because clinical research is highly protocol-specific, forms-development processes are more easily standardized than is CRF content. Tools that support retrieval and reuse of existing items will enable standards adoption in clinical research applications. Such tools will depend upon formal relationships between items and terminological standards. Future standards adoption will depend upon standardized approaches for bridging generic structural standards and domain-specific content standards. Clinical research informatics can help define tools requirements in terms of workflow support for research activities, reconcile the perspectives of varied clinical research stakeholders, and coordinate standards efforts toward interoperability across healthcare and research data collection.

A novel network module for medical devices.

PubMed

Chen, Ping-Yu

2008-01-01

In order to allow medical devices to upload the vital signs to a server on a network without manually configuring for end-users, a new network module is proposed. The proposed network module, called Medical Hub (MH), functions as a bridge to fetch the data from all connecting medical devices, and then upload these data to the server. When powering on, the MH can immediately establish network configuration automatically. Network Address Translation (NAT) traversal is also supported by the MH with the UPnP Internet Gateway Device (IGD) methodology. Besides the network configuration, other configuration in the MH is automatically established by using the remote management protocol TR-069. On the other hand, a mechanism for updating software automatically according to the variant connected medical device is proposed. With this mechanism, newcome medical devices can be detected and supported by the MH without manual operation.

Correlated fluorescence microscopy and cryo-electron tomography of virus-infected or transfected mammalian cells

PubMed Central

Hampton, Cheri M; Strauss, Joshua D; Ke, Zunlong; Dillard, Rebecca S; Hammonds, Jason E; Alonas, Eric; Desai, Tanay M; Marin, Mariana; Storms, Rachel E; Leon, Fredrick; Melikyan, Gregory B; Santangelo, Philip J; Spearman, Paul W; Wright, Elizabeth R

2016-01-01

Correlative light and electron microscopy (CLEM) combines spatiotemporal information from fluorescence light microscopy (fLM) with high-resolution structural data from cryo-electron tomography (cryo-ET). These technologies provide opportunities to bridge knowledge gaps between cell and structural biology. Here we describe our protocol for correlated cryo-fLM, cryo-electron microscopy (cryo-EM), and cryo-ET (i.e., cryo-CLEM) of virus-infected or transfected mammalian cells. Mammalian-derived cells are cultured on EM substrates, using optimized conditions that ensure that the cells are spread thinly across the substrate and are not physically disrupted. The cells are then screened by fLM and vitrified before acquisition of cryo-fLM and cryo-ET images, which is followed by data processing. A complete session from grid preparation through data collection and processing takes 5–15 d for an individual experienced in cryo-EM. PMID:27977021

Mutually unbiased coarse-grained measurements of two or more phase-space variables

NASA Astrophysics Data System (ADS)

Paul, E. C.; Walborn, S. P.; Tasca, D. S.; Rudnicki, Łukasz

2018-05-01

Mutual unbiasedness of the eigenstates of phase-space operators—such as position and momentum, or their standard coarse-grained versions—exists only in the limiting case of infinite squeezing. In Phys. Rev. Lett. 120, 040403 (2018), 10.1103/PhysRevLett.120.040403, it was shown that mutual unbiasedness can be recovered for periodic coarse graining of these two operators. Here we investigate mutual unbiasedness of coarse-grained measurements for more than two phase-space variables. We show that mutual unbiasedness can be recovered between periodic coarse graining of any two nonparallel phase-space operators. We illustrate these results through optics experiments, using the fractional Fourier transform to prepare and measure mutually unbiased phase-space variables. The differences between two and three mutually unbiased measurements is discussed. Our results contribute to bridging the gap between continuous and discrete quantum mechanics, and they could be useful in quantum-information protocols.

Towards in vivo focal cortical dysplasia phenotyping using quantitative MRI.

PubMed

Adler, Sophie; Lorio, Sara; Jacques, Thomas S; Benova, Barbora; Gunny, Roxana; Cross, J Helen; Baldeweg, Torsten; Carmichael, David W

2017-01-01

Focal cortical dysplasias (FCDs) are a range of malformations of cortical development each with specific histopathological features. Conventional radiological assessment of standard structural MRI is useful for the localization of lesions but is unable to accurately predict the histopathological features. Quantitative MRI offers the possibility to probe tissue biophysical properties in vivo and may bridge the gap between radiological assessment and ex-vivo histology. This review will cover histological, genetic and radiological features of FCD following the ILAE classification and will explain how quantitative voxel- and surface-based techniques can characterise these features. We will provide an overview of the quantitative MRI measures available, their link with biophysical properties and finally the potential application of quantitative MRI to the problem of FCD subtyping. Future research linking quantitative MRI to FCD histological properties should improve clinical protocols, allow better characterisation of lesions in vivo and tailored surgical planning to the individual.

Real-time long term measurement using integrated framework for ubiquitous smart monitoring

NASA Astrophysics Data System (ADS)

Heo, Gwanghee; Lee, Giu; Lee, Woosang; Jeon, Joonryong; Kim, Pil-Joong

2007-04-01

Ubiquitous monitoring combining internet technologies and wireless communication is one of the most promising technologies of infrastructure health monitoring against the natural of man-made hazards. In this paper, an integrated framework of the ubiquitous monitoring is developed for real-time long term measurement in internet environment. This framework develops a wireless sensor system based on Bluetooth technology and sends measured acceleration data to the host computer through TCP/IP protocol. And it is also designed to respond to the request of web user on real time basis. In order to verify this system, real time monitoring tests are carried out on a prototype self-anchored suspension bridge. Also, wireless measurement system is analyzed to estimate its sensing capacity and evaluate its performance for monitoring purpose. Based on the evaluation, this paper proposes the effective strategies for integrated framework in order to detect structural deficiencies and to design an early warning system.

Ocular Tropism of Respiratory Viruses

PubMed Central

Rota, Paul A.; Tumpey, Terrence M.

2013-01-01

SUMMARY Respiratory viruses (including adenovirus, influenza virus, respiratory syncytial virus, coronavirus, and rhinovirus) cause a broad spectrum of disease in humans, ranging from mild influenza-like symptoms to acute respiratory failure. While species D adenoviruses and subtype H7 influenza viruses are known to possess an ocular tropism, documented human ocular disease has been reported following infection with all principal respiratory viruses. In this review, we describe the anatomical proximity and cellular receptor distribution between ocular and respiratory tissues. All major respiratory viruses and their association with human ocular disease are discussed. Research utilizing in vitro and in vivo models to study the ability of respiratory viruses to use the eye as a portal of entry as well as a primary site of virus replication is highlighted. Identification of shared receptor-binding preferences, host responses, and laboratory modeling protocols among these viruses provides a needed bridge between clinical and laboratory studies of virus tropism. PMID:23471620

Biological approach to treatment of intra-articular proximal tibial fractures with double osteosynthesis.

PubMed

Singh, Saurabh; Patel, Pankaj R; Joshi, Anil Kumar; Naik, Rajnikant N; Nagaraj, Chethan; Kumar, Sudeep

2009-02-01

The treatment of intra-articular proximal tibial fractures is associated with complications, and much conflicting literature exists concerning the treatment of choice. In our study, an attempt has been made to develop an ideal and adequate treatment protocol for these intra-articular fractures. The principle of double osteosynthesis, i.e., lateral minimally invasive plate osteosynthesis (MIPO), was combined with a medial external fixator to treat 22 intra-articular proximal tibial fractures with soft tissue injury with a mean follow-up of 25 months. Superficial pin track infection was observed in one case, and no soft tissue breakdown was noted. Loss of articular reconstruction was reported in one case. Bridging callus was seen at 12 weeks (8 weeks-7 months). The principle of substitution or double osteosynthesis, i.e., lateral MIPO, was combined with a medial external fixator and proved to be a fairly good method of fixation in terms of results and complications.

3. View of Clark Fork Vehicle Bridge facing southwest. Bridge ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

3. View of Clark Fork Vehicle Bridge facing southwest. Bridge from north shore of Clark Fork River. - Clark Fork Vehicle Bridge, Spanning Clark Fork River, serves Highway 200, Clark Fork, Bonner County, ID

Parryville Bridge (S.R. 2008, section 01B Bridge) looking north across ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Parryville Bridge (S.R. 2008, section 01B Bridge) looking north across traffic level, showing village of Parryville. - Parryville Bridge, State Route 2008 over Pohapoco Creek, Parryville, Carbon County, PA

Australian Space Situational Awareness Capability Demonstrations

NASA Astrophysics Data System (ADS)

Morreale, B.; Bessell, T.; Rutten, M.; Cheung, B.

Australia is increasing its contribution to the global space situational awareness (SSA) problem by committing to acquire and operate SSA sensors. Over the last year, a series of collaborative SSA experiments have been undertaken to demonstrate the capabilities of Australian sensors. These experiments aimed to demonstrate how existing Australian sensors could perform in a surveillance of space role, prove passive radar’s capability to observe low earth orbit (LEO) satellites and perform SSA handoffs to optical sensors. The trials established a data sharing and communications protocol that bridged defence, academia, and industry partners. Geographically dispersed optical assets, including the Falcon telescope in Canberra, Raven telescopes in Exmouth (Western Australia) and Defence Science and Technology (DST) Telescopes in Adelaide (South Australia) collected on LEO satellites and established cueing protocols. The Murchison Widefield Array (MWA) located in Western Australia, demonstrated the capability of passive radar as an SSA asset after successfully observing LEO satellites based on reflected terrestrial radio signals. The combination of radar and optical SSA assets allows for the exploitation of each sensors unique advantages and locations across the Australian continent. This paper outlines the capabilities and diversity of Australian optical and radar sensors as demonstrated by field trials in 2016 and 2017. It suggests future potential for harnessing novel radar and optical integration techniques to supplement high-value assets such as the Space Surveillance Telescope as part of the Space Surveillance Network.

Microwave-assisted solid-phase peptide synthesis of the 60-110 domain of human pleiotrophin on 2-chlorotrityl resin.

PubMed

Friligou, Irene; Papadimitriou, Evangelia; Gatos, Dimitrios; Matsoukas, John; Tselios, Theodore

2011-05-01

A fast and efficient microwave-assisted solid phase peptide synthesis (MW-SPPS) of a 51mer peptide, the main heparin-binding site (60-110) of human pleiotrophin (hPTN), using 2-chlorotrityl chloride resin (CLTR-Cl) following the 9-fluorenylmethyloxycarbonyl/tert-butyl (Fmoc/tBu) methodology and with the standard N,N'-diisopropylcarbodiimide/1-hydroxybenzotriazole (DIC/HOBt) coupling reagents, is described. An MW-SPPS protocol was for the first time successfully applied to the acid labile CLTR-Cl for the faster synthesis of long peptides (51mer peptide) and with an enhanced purity in comparison to conventional SPPS protocols. The synthesis of such long peptides is not trivial and it is generally achieved by recombinant techniques. The desired linear peptide was obtained in only 30 h of total processing time and in 51% crude yield, in which 60% was the purified product obtained with 99.4% purity. The synthesized peptide was purified by reversed phase high performance liquid chromatography (RP-HPLC) and identified by electrospray ionization mass spectrometry (ESI-MS). Then, the regioselective formation of the two disulfide bridges of hPTN 60-110 was successfully achieved by a two-step procedure, involving an oxidative folding step in dimethylsulfoxide (DMSO) to form the Cys(77)-Cys(109) bond, followed by iodine oxidation to form the Cys(67)-Cys(99) bond.

A review of blood sample handling and pre-processing for metabolomics studies.

PubMed

Hernandes, Vinicius Veri; Barbas, Coral; Dudzik, Danuta

2017-09-01

Metabolomics has been found to be applicable to a wide range of clinical studies, bringing a new era for improving clinical diagnostics, early disease detection, therapy prediction and treatment efficiency monitoring. A major challenge in metabolomics, particularly untargeted studies, is the extremely diverse and complex nature of biological specimens. Despite great advances in the field there still exist fundamental needs for considering pre-analytical variability that can introduce bias to the subsequent analytical process and decrease the reliability of the results and moreover confound final research outcomes. Many researchers are mainly focused on the instrumental aspects of the biomarker discovery process, and sample related variables sometimes seem to be overlooked. To bridge the gap, critical information and standardized protocols regarding experimental design and sample handling and pre-processing are highly desired. Characterization of a range variation among sample collection methods is necessary to prevent results misinterpretation and to ensure that observed differences are not due to an experimental bias caused by inconsistencies in sample processing. Herein, a systematic discussion of pre-analytical variables affecting metabolomics studies based on blood derived samples is performed. Furthermore, we provide a set of recommendations concerning experimental design, collection, pre-processing procedures and storage conditions as a practical review that can guide and serve for the standardization of protocols and reduction of undesirable variation. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

33 CFR 165.1187 - Security Zones; Golden Gate Bridge and the San Francisco-Oakland Bay Bridge, San Francisco Bay...

Code of Federal Regulations, 2011 CFR

2011-07-01

... Bridge and the San Francisco-Oakland Bay Bridge, San Francisco Bay, California. 165.1187 Section 165.1187... Limited Access Areas Eleventh Coast Guard District § 165.1187 Security Zones; Golden Gate Bridge and the San Francisco-Oakland Bay Bridge, San Francisco Bay, California. (a) Location. All waters extending...

25 CFR 170.504 - When and how are bridge inspections performed?

Code of Federal Regulations, 2011 CFR

2011-04-01

... 25 Indians 1 2011-04-01 2011-04-01 false When and how are bridge inspections performed? 170.504... Bridge Inspection § 170.504 When and how are bridge inspections performed? IRR bridge inspections must be... standards (23 CFR 650.305). (a) Federal standards for bridge inspections are found in 23 CFR part 650...

78 FR 56605 - Drawbridge Operation Regulation; Lafourche Bayou, Larose, LA

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-13

... reference to the SR 310 (Larose Pontoon) Bridge with the LA 657 (Larose) Vertical Lift Bridge. The SR 310...) Vertical Lift Bridge, which is located approximately one-half mile away from the old bridge. The old SR 310....1. This bridge has been replaced by the newly constructed LA 657 (Larose) Vertical Lift Bridge...

77 FR 44463 - Drawbridge Operation Regulations; Gulf Intracoastal Waterway, Sarasota, FL

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-30

... Bridge, mile 49.9, across the Gulf Intracoastal Waterway; the Tom Adams Bridge, mile 43.5, across the... the Venice Airport Bridge, the North Manasota Bridge, the Tom Adams Bridge, and the Venice Avenue... October 28, 2012. Tugs and tugs with tows are not exempt from this deviation. 3. Tom Adams Bridge, mile 43...

33 CFR 165.1187 - Security Zones; Golden Gate Bridge and the San Francisco-Oakland Bay Bridge, San Francisco Bay...

Code of Federal Regulations, 2010 CFR

2010-07-01

... Bridge and the San Francisco-Oakland Bay Bridge, San Francisco Bay, California. 165.1187 Section 165.1187... Limited Access Areas Eleventh Coast Guard District § 165.1187 Security Zones; Golden Gate Bridge and the San Francisco-Oakland Bay Bridge, San Francisco Bay, California. (a) Location. All waters extending...

Multi-Hazard Assessment of Scour Damaged Bridges with UAS-Based Measurements

NASA Astrophysics Data System (ADS)

Özcan, O.; Ozcan, O.

2017-12-01

Flood and stream induced scour occurring in bridge piers constructed on rivers is one of the mostly observed failure reasons in bridges. Scour induced failure risk in bridges and determination of the alterations in bridge safety under seismic effects has the ultimate importance. Thus, for the determination of bridge safety under the scour effects, the scour amount under bridge piers should be designated realistically and should be tracked and updated continuously. Hereby, the scour induced failures in bridge foundation systems will be prevented and bridge substructure design will be conducted safely. In this study, in order to measure the amount of scour in bridge load bearing system (pile foundations and pile abutments) and to attain very high definition 3 dimensional models of river flood plain for the flood analysis, unmanned aircraft system (UAS) based measurement methods were implemented. UAS based measurement systems provide new and practical approach and bring high precision and reliable solutions considering recent measurement systems. For this purpose, the reinforced concrete (RC) bridge that is located on Antalya Boğaçayı River, Turkey and that failed in 2003 due to flood-induced scour was selected as the case study. The amount of scour occurred in bridge piers and piles was determined realistically and the behavior of bridge piers under scour effects was investigated. Future flood effects and the resultant amount of scour was determined with HEC-RAS software by using digital surface models that were obtained at regular intervals using UAS for the riverbed. In the light of the attained scour measurements and expected scour after a probable flood event, the behavior of scour damaged RC bridge was investigated by pushover and time history analyses under lateral and vertical seismic loadings. In the analyses, the load and displacement capacity of bridge was observed to diminish significantly under expected scour. Thus, the deterioration in multi hazard performance of the bridge was monitored significantly in the light of updated bridge load bearing system capacity. Regarding the case study, UAS based and continuously updated bridge multi hazard risk detection system was established that can be used for bridges located on riverbed.

Streamflow and streambed scour in 2010 at bridge 339, Copper River, Alaska

USGS Publications Warehouse

Conaway, Jeffrey S.; Brabets, Timothy P.

2011-01-01

The distribution of the Copper River's discharge through the bridges was relatively stable until sometime between 1969-70 and 1982-85. The majority of the total Copper River discharge in 1969-70 passed through three bridges on the western side of the delta, but by 1982-1985, 25 to 62 percent of the flow passed through bridge 342 on the eastern side of the Copper River Delta. In 2004, only 8 percent of the flow passed through the western bridges, while 90 percent of the discharge flowed through two bridges on the eastern side of the delta. Migration of the river across the delta and redistribution of discharge has resulted in streambed scour at some bridges, overtopping of the road during high flows, prolonged highway closures, and formation of new channels through forests. Scour monitoring at the eastern bridges has recorded as much as 44 feet of fill at one pier and 33 feet of scour at another. In 2009, flow distribution began to shift from the larger bridge 342 to bridge 339. In 2010, flow in excess of four times the design discharge scoured the streambed at bridge 339 to a level such that constant on-site monitoring was required to evaluate the potential need for bridge closure. In 2010, instantaneous flow through bridge 339 was never less than 30 percent and was as high as 49 percent of the total Copper River discharge. The percentage of flow through bridge 339 decreased when the overall Copper River discharge increased. The increased discharge through bridge 339 is attributed to a shift in the approach channel 3,500 feet upstream. Bridge channel alignment and analysis of flow distribution as of October 2010 indicate these hydrologic hazards will persist in 2011.

Wind Tunnel Measurements for Flutter of a Long-Afterbody Bridge Deck

PubMed Central

Chen, Zeng-Shun; Zhang, Cheng; Wang, Xu; Ma, Cun-Ming

2017-01-01

Bridges are an important component of transportation. Flutter is a self-excited, large amplitude vibration, which may lead to collapse of bridges. It must be understood and avoided. This paper takes the Jianghai Channel Bridge, which is a significant part of the Hong Kong-Zhuhai-Macao Bridge, as an example to investigate the flutter of the bridge deck. Firstly, aerodynamic force models for flutter of bridges were introduced. Then, wind tunnel tests of the bridge deck during the construction and the operation stages, under different wind attack angles and wind velocities, were carried out using a high frequency base balance (HFBB) system and laser displacement sensors. From the tests, the static aerodynamic forces and flutter derivatives of the bridge deck were observed. Correspondingly, the critical flutter wind speeds of the bridge deck were determined based on the derivatives, and they are compared with the directly measured flutter speeds. Results show that the observed derivatives are reasonable and applicable. Furthermore, the critical wind speeds in the operation stage is smaller than those in the construction stage. Besides, the flutter instabilities of the bridge in the construction and the operation stages are good. This study helps guarantee the design and the construction of the Jianghai Channel Bridge, and advances the understanding of flutter of long afterbody bridge decks. PMID:28208773

Wind Tunnel Measurements for Flutter of a Long-Afterbody Bridge Deck.

PubMed

Chen, Zeng-Shun; Zhang, Cheng; Wang, Xu; Ma, Cun-Ming

2017-02-09

Bridges are an important component of transportation. Flutter is a self-excited, large amplitude vibration, which may lead to collapse of bridges. It must be understood and avoided. This paper takes the Jianghai Channel Bridge, which is a significant part of the Hong Kong-Zhuhai-Macao Bridge, as an example to investigate the flutter of the bridge deck. Firstly, aerodynamic force models for flutter of bridges were introduced. Then, wind tunnel tests of the bridge deck during the construction and the operation stages, under different wind attack angles and wind velocities, were carried out using a high frequency base balance (HFBB) system and laser displacement sensors. From the tests, the static aerodynamic forces and flutter derivatives of the bridge deck were observed. Correspondingly, the critical flutter wind speeds of the bridge deck were determined based on the derivatives, and they are compared with the directly measured flutter speeds. Results show that the observed derivatives are reasonable and applicable. Furthermore, the critical wind speeds in the operation stage is smaller than those in the construction stage. Besides, the flutter instabilities of the bridge in the construction and the operation stages are good. This study helps guarantee the design and the construction of the Jianghai Channel Bridge, and advances the understanding of flutter of long afterbody bridge decks.

Experience and prospects of oil shale utilization for power production in Russia

NASA Astrophysics Data System (ADS)

Potapov, O. P.

2016-09-01

Due to termination of work at the Leningrad Shale Deposit, the Russian shale industry has been liquidated, including not only shale mining and processing but also research and engineering (including design) activities, because this deposit was the only commercially operated complex in Russia. UTT-3000 plants with solid heat carrier, created mainly by the Russian specialists under scientific guidance of members of Krzhizhanovsky Power Engineering Institute, passed under the control of Estonian engineers, who, alongside with their operation in Narva, construct similar plants in Kohtla-Jarve, having renamed the Galoter Process into the Enifit or Petroter. The main idea of this article is to substantiate the expediency of revival of the oil shale industry in Russia. Data on the UTT-3000 plants' advantages, shale oils, and gas properties is provided. Information on investments in an UTT-3000 plant and estimated cost of Leningrad oil shale mining at the Mezhdurechensk Strip Mine is given. For more detailed technical and economic assessment of construction of a complex for oil shale extraction and processing, it is necessary to develop a feasibility study, which should be the first stage of this work. Creation of such a complex will make it possible to produce liquid and gaseous power fuel from oil shale of Leningrad Deposit and provide the opportunity to direct for export the released volumes of oil and gas for the purposes of Russian budget currency replenishment.

4. View of Clark Fork Vehicle Bridge facing northeast. Bridge ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. View of Clark Fork Vehicle Bridge facing northeast. Bridge from south shoreof Clark Fork River showing 4 spans. - Clark Fork Vehicle Bridge, Spanning Clark Fork River, serves Highway 200, Clark Fork, Bonner County, ID

Long-term bridge performance high priority bridge performance issues.

DOT National Transportation Integrated Search

2014-10-01

Bridge performance is a multifaceted issue involving performance of materials and protective systems, : performance of individual components of the bridge, and performance of the structural system as a whole. The : Long-Term Bridge Performance (LTBP)...

Newport Pell Bridge traffic and revenue study

DOT National Transportation Integrated Search

2010-01-12

Jacobs Engineering conducted a traffic and toll revenue study for the Claiborne Pell Newport Bridge : (Newport Pell Bridge or Pell Bridge) upon the request of the Rhode Island Turnpike and Bridge : Authority (RITBA). This study is being c...

Evaluation of the service performance of bridge components.

DOT National Transportation Integrated Search

2004-08-01

This study was initiated to provide review of common bridges to determine the performance of their components. Seven bridge types were selected that constituted 85 % of the Kentucky Transportation Cabinet (KYTC) bridge inventory. 319 bridges were ins...

Instrumentation to Aid in Steel Bridge Fabrication : Bridge Virtual Assembly System

DOT National Transportation Integrated Search

2018-05-01

This pool funded project developed a BRIDGE VIRTUAL ASSEMBLY SYSTEM (BRIDGE VAS) that improves manufacturing processes and enhances quality control for steel bridge fabrication. The system replaces conventional match-drilling with virtual assembly me...

Multiple Channel Bridges for Spinal Cord Injury: Cellular Characterization of Host Response

PubMed Central

Yang, Yang; Laporte, Laura De; Zelivyanskaya, Marina L.; Whittlesey, Kevin J.; Anderson, Aileen J.; Cummings, Brian J.

2009-01-01

Bridges for treatment of the injured spinal cord must stabilize the injury site to prevent secondary damage and create a permissive environment that promotes regeneration. The host response to the bridge is central to creating a permissive environment, as the cell types that respond to the injury have the potential to secrete both stimulatory and inhibitory factors. We investigated multiple channel bridges for spinal cord regeneration and correlated the bridge structure to cell infiltration and axonal elongation. Poly(lactide-co-glycolide) bridges were fabricated by a gas foaming/particulate leaching process. Channels within the bridge had diameters of 150 or 250 μm, and the main body of the bridge was highly porous with a controllable pore size. Upon implantation in a rat spinal cord hemisection site, cells infiltrated into the bridge pores and channels, with the pore size influencing the rate of infiltration. The pores had significant cell infiltration, including fibroblasts, macrophages, S-100β-positive cells, and endothelial cells. The channels of the bridge were completely infiltrated with cells, which had aligned axially, and consisted primarily of fibroblasts, S-100β-positive cells, and endothelial cells. Reactive astrocytes were observed primarily outside of the bridge, and staining for chondroitin sulfate proteoglycans was decreased in the region surrounding the bridge relative to studies without bridges. Neurofilament staining revealed a preferential growth of the neural fibers within the bridge channels relative to the pores. Multiple channel bridges capable of supporting cellular infiltration, creating a permissive environment, and directing the growth of neural fibers have potential for promoting and directing spinal cord regeneration. PMID:19382871

The effects of performing a one-legged bridge with hip abduction and use of a sling on trunk and lower extremity muscle activation in healthy adults.

PubMed

Choi, Kyuju; Bak, Jongwoo; Cho, Minkwon; Chung, Yijung

2016-09-01

[Purpose] This study investigated the changes in the muscle activities of the trunk and lower limbs of healthy adults during a one-legged bridge exercise using a sling, and with the addition of hip abduction. [Subjects and Methods] Twenty-seven healthy individuals participated in this study (14 males and 13 females). The participants were instructed to perform the bridge exercises under five different conditions. Trunk and lower limb muscle activation of the erector spinae (ES), external oblique (EO), gluteus maximus (GM), and biceps femoris (BF) was measured using surface electromyography. Data analysis was performed using the mean scores of three trials performed under each condition. [Results] There was a significant increase in bilateral EO and contralateral GM with the one-legged bridge compared with the one-legged bridge with sling exercise. Muscle activation of the ipsilateral GM and BF was significantly less during the one-legged bridge exercise compared to the one-legged bridge with sling exercise, and was significantly greater during the one-legged bridge with hip abduction compared to the one-legged bridge exercise. The muscle activation of the contralateral GM and BF was significantly greater with the one-legged bridge with hip abduction compared to the general bridge exercise. [Conclusion] With the one-legged bridge with hip abduction, the ipsilateral EO, GM and BF muscle activities were significantly greater than those of the one-legged bridge exercise. The muscle activation of all trunk and contralateral lower extremity muscles increased with the bridge with sling exercises compared with general bridge exercises.

21. View of Clark Fork Vehicle Bridge facing west. Looking ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

21. View of Clark Fork Vehicle Bridge facing west. Looking at bridge deck, guard rail, juncture of two bridge spans. - Clark Fork Vehicle Bridge, Spanning Clark Fork River, serves Highway 200, Clark Fork, Bonner County, ID

Structural characterization of UHPC waffle bridge deck and connections.

DOT National Transportation Integrated Search

2014-07-01

The AASHTO strategic plan in 2005 for bridge engineering identified extending the service life of bridges and accelerating bridge : construction as two of the grand challenges in bridge engineering. These challenges have the objective of producing sa...

Bridge health monitoring metrics : updating the bridge deficiency algorithm.

DOT National Transportation Integrated Search

2009-10-01

As part of its bridge management system, the Alabama Department of Transportation (ALDOT) must decide how best to spend its bridge replacement funds. In making these decisions, ALDOT managers currently use a deficiency algorithm to rank bridges that ...

Load ratings for secondary bridges.

DOT National Transportation Integrated Search

1991-05-01

A load rating states the load in tons which a vehicle can impose on a bridge. : Changes in guidelines, standards, and customary uses of bridges require : analyses of bridges to be updated and re-evaluated. : In this report, twenty-two secondary bridg...

Phase and widening construction of steel bridges : [summary].

DOT National Transportation Integrated Search

2014-03-01

Maintaining traffic flow for bridge widening and replacement projects often requires bridges to be constructed in phases so that traffic can travel on one : portion of the bridge while another portion is being : constructed. The bridge portions are t...

Dynamic assessment of bridge deck performance considering realistic bridge-traffic interaction

DOT National Transportation Integrated Search

2017-09-01

Concrete bridge decks are directly exposed to daily traffic loads and may experience some surface cracking caused by excessive stress or fatigue accumulation, which requires repair or replacement. Among typical bridges in North America, bridge decks ...

33 CFR 117.501 - Teche Bayou.

Code of Federal Regulations, 2012 CFR

2012-07-01

... bridges shall open on signal if at least four hours notice is given: (1) St. Mary Parish bridge, mile 3.9 at Calumet. (2) St. Mary Parish bridge, mile 11.8 at Centerville. (3) S3069 bridge, mile 16.3 at Franklin. (4) S322 bridge, mile 17.2 at Franklin. (5) S323 bridge, mile 22.3 at Oaklawn. (6) St. Mary...

33 CFR 117.501 - Teche Bayou.

Code of Federal Regulations, 2014 CFR

2014-07-01

... bridges shall open on signal if at least four hours notice is given: (1) St. Mary Parish bridge, mile 3.9 at Calumet. (2) St. Mary Parish bridge, mile 11.8 at Centerville. (3) S3069 bridge, mile 16.3 at Franklin. (4) S322 bridge, mile 17.2 at Franklin. (5) S323 bridge, mile 22.3 at Oaklawn. (6) St. Mary...

33 CFR 117.501 - Teche Bayou.

Code of Federal Regulations, 2011 CFR

2011-07-01

... bridges shall open on signal if at least four hours notice is given: (1) St. Mary Parish bridge, mile 3.9 at Calumet. (2) St. Mary Parish bridge, mile 11.8 at Centerville. (3) S3069 bridge, mile 16.3 at Franklin. (4) S322 bridge, mile 17.2 at Franklin. (5) S323 bridge, mile 22.3 at Oaklawn. (6) St. Mary...

33 CFR 117.501 - Teche Bayou.

Code of Federal Regulations, 2013 CFR

2013-07-01

... bridges shall open on signal if at least four hours notice is given: (1) St. Mary Parish bridge, mile 3.9 at Calumet. (2) St. Mary Parish bridge, mile 11.8 at Centerville. (3) S3069 bridge, mile 16.3 at Franklin. (4) S322 bridge, mile 17.2 at Franklin. (5) S323 bridge, mile 22.3 at Oaklawn. (6) St. Mary...

33 CFR 117.501 - Teche Bayou.

Code of Federal Regulations, 2010 CFR

2010-07-01

... bridges shall open on signal if at least four hours notice is given: (1) St. Mary Parish bridge, mile 3.9 at Calumet. (2) St. Mary Parish bridge, mile 11.8 at Centerville. (3) S3069 bridge, mile 16.3 at Franklin. (4) S322 bridge, mile 17.2 at Franklin. (5) S323 bridge, mile 22.3 at Oaklawn. (6) St. Mary...

Designing timber bridge superstructures : a comparison of U.S. and Canadian bridge codes.

Treesearch

James Scott Groenier; James P. Wacker

2008-01-01

Several changes relating to timber bridges have been incorporated into the AASHTO-LRFD Bridge Design Specifications recently. In addition, the Federal Highway Administration is strongly encouraging an LRFD-based design approach for all new bridges in the United States. The Bridge Design Code in Canada was one of the first to adopt the limit states design philosophy,...

Field performance of timber bridges. 6, Hoffman Run stress-laminated deck bridge

Treesearch

M. A. Ritter; P. D. Hilbrich Lee; G. J. Porter

The Hoffman Run bridge, located just outside Dahoga, Pennsylvania, was constructed in October 1990. The bridge is a simple-span, single-lane, stress-laminated deck superstructure that is approximately 26 ft long and 16 ft wide. It is the second stress-laminated timber bridge to be constructed of hardwood lumber in Pennsylvania. The performance of the bridge was...

Bridge Programs in Illinois: Results of the 2010 Illinois Bridge Status Survey

ERIC Educational Resources Information Center

Taylor, J. L.; Harmon, T.

2010-01-01

This report provides a summary of major results of the Illinois Bridge Status Survey, administered online between April and June 2010. The purpose of the survey was to understand the extent to which bridge programs are being implemented in Illinois, as well as to build an online directory of bridge programs. Bridge programs are an emerging…

Recent research and applications of numerical simulation for dynamic response of long-span bridges subjected to multiple loads.

PubMed

Chen, Zhiwei; Chen, Bo

2014-01-01

Many long-span bridges have been built throughout the world in recent years but they are often subject to multiple types of dynamic loads, especially those located in wind-prone regions and carrying both trains and road vehicles. To ensure the safety and functionality of these bridges, dynamic responses of long-span bridges are often required for bridge assessment. Given that there are several limitations for the assessment based on field measurement of dynamic responses, a promising approach is based on numerical simulation technologies. This paper provides a detailed review of key issues involved in dynamic response analysis of long-span multiload bridges based on numerical simulation technologies, including dynamic interactions between running trains and bridge, between running road vehicles and bridge, and between wind and bridge, and in the wind-vehicle-bridge coupled system. Then a comprehensive review is conducted for engineering applications of newly developed numerical simulation technologies to safety assessment of long-span bridges, such as assessment of fatigue damage and assessment under extreme events. Finally, the existing problems and promising research efforts for the numerical simulation technologies and their applications to assessment of long-span multiload bridges are explored.

Research of diagnosis sensors fault based on correlation analysis of the bridge structural health monitoring system

NASA Astrophysics Data System (ADS)

Hu, Shunren; Chen, Weimin; Liu, Lin; Gao, Xiaoxia

2010-03-01

Bridge structural health monitoring system is a typical multi-sensor measurement system due to the multi-parameters of bridge structure collected from the monitoring sites on the river-spanning bridges. Bridge structure monitored by multi-sensors is an entity, when subjected to external action; there will be different performances to different bridge structure parameters. Therefore, the data acquired by each sensor should exist countless correlation relation. However, complexity of the correlation relation is decided by complexity of bridge structure. Traditionally correlation analysis among monitoring sites is mainly considered from physical locations. unfortunately, this method is so simple that it cannot describe the correlation in detail. The paper analyzes the correlation among the bridge monitoring sites according to the bridge structural data, defines the correlation of bridge monitoring sites and describes its several forms, then integrating the correlative theory of data mining and signal system to establish the correlation model to describe the correlation among the bridge monitoring sites quantificationally. Finally, The Chongqing Mashangxi Yangtze river bridge health measurement system is regards as research object to diagnosis sensors fault, and simulation results verify the effectiveness of the designed method and theoretical discussions.

Stabilization of a capillary bridge far beyond the Rayleigh--Plateau limit using active feedback and acoustic radiation pressure.

NASA Astrophysics Data System (ADS)

Marr-Lyon, Mark J.; Thiessen, David B.; Marston, Philip L.

1997-11-01

A liquid bridge between two solid surfaces is known as a capillary bridge. For a cylindrical bridge in low gravity of radius R and length L, the slenderness S=L/2R has a natural (Rayleigh--Plateau) limit of π beyond which the bridge breaks. Using the radiation pressure of an ultrasonic standing wave to control the shape of the bridge and an optical sensor to detect the shape of the bridge, an active feedback system was constructed that stabilized bridges significantly beyond the Rayleigh limit in simulated low gravity(Marr--Lyon, M. J., phet al., J. Fluid Mech.), accepted for publication.. The Plateau tank which contained the bridge was a dual frequency ultrasonic resonator and the spatial distribution of the radiation pressure was controlled by adjusting the ultrasonic frequency. Bridges have been extended with S as large as 4.3. To be useful in low gravity, modifications for liquid bridges in air are needed. Acoustic resonators in air having the required property that the sound amplitude can be spatially redistributed rapidly are being investigated using gas-filled soap-film bridges. Work supported by NASA.

Recent Research and Applications of Numerical Simulation for Dynamic Response of Long-Span Bridges Subjected to Multiple Loads

PubMed Central

Chen, Zhiwei; Chen, Bo

2014-01-01

Many long-span bridges have been built throughout the world in recent years but they are often subject to multiple types of dynamic loads, especially those located in wind-prone regions and carrying both trains and road vehicles. To ensure the safety and functionality of these bridges, dynamic responses of long-span bridges are often required for bridge assessment. Given that there are several limitations for the assessment based on field measurement of dynamic responses, a promising approach is based on numerical simulation technologies. This paper provides a detailed review of key issues involved in dynamic response analysis of long-span multiload bridges based on numerical simulation technologies, including dynamic interactions between running trains and bridge, between running road vehicles and bridge, and between wind and bridge, and in the wind-vehicle-bridge coupled system. Then a comprehensive review is conducted for engineering applications of newly developed numerical simulation technologies to safety assessment of long-span bridges, such as assessment of fatigue damage and assessment under extreme events. Finally, the existing problems and promising research efforts for the numerical simulation technologies and their applications to assessment of long-span multiload bridges are explored. PMID:25006597

Methodology capture: discriminating between the "best" and the rest of community practice

PubMed Central

Eales, James M; Pinney, John W; Stevens, Robert D; Robertson, David L

2008-01-01

Background The methodologies we use both enable and help define our research. However, as experimental complexity has increased the choice of appropriate methodologies has become an increasingly difficult task. This makes it difficult to keep track of available bioinformatics software, let alone the most suitable protocols in a specific research area. To remedy this we present an approach for capturing methodology from literature in order to identify and, thus, define best practice within a field. Results Our approach is to implement data extraction techniques on the full-text of scientific articles to obtain the set of experimental protocols used by an entire scientific discipline, molecular phylogenetics. Our methodology for identifying methodologies could in principle be applied to any scientific discipline, whether or not computer-based. We find a number of issues related to the nature of best practice, as opposed to community practice. We find that there is much heterogeneity in the use of molecular phylogenetic methods and software, some of which is related to poor specification of protocols. We also find that phylogenetic practice exhibits field-specific tendencies that have increased through time, despite the generic nature of the available software. We used the practice of highly published and widely collaborative researchers ("expert" researchers) to analyse the influence of authority on community practice. We find expert authors exhibit patterns of practice common to their field and therefore act as useful field-specific practice indicators. Conclusion We have identified a structured community of phylogenetic researchers performing analyses that are customary in their own local community and significantly different from those in other areas. Best practice information can help to bridge such subtle differences by increasing communication of protocols to a wider audience. We propose that the practice of expert authors from the field of evolutionary biology is the closest to contemporary best practice in phylogenetic experimental design. Capturing best practice is, however, a complex task and should also acknowledge the differences between fields such as the specific context of the analysis. PMID:18761740

A Confirmation of the Quench-Cryoannealing Relaxation Protocol for Identifying Reduction States of Freeze-Trapped Nitrogenase Intermediates

PubMed Central

2015-01-01

We have advanced a mechanism for nitrogenase catalysis that rests on the identification of a low-spin EPR signal (S = 1/2) trapped during turnover of a MoFe protein as the E4 state, which has accumulated four reducing equivalents as two [Fe–H–Fe] bridging hydrides. Because electrons are delivered to the MoFe protein one at a time, with the rate-limiting step being the off-rate of oxidized Fe protein, it is difficult to directly control, or know, the degree of reduction, n, of a trapped intermediate, denoted En, n = 1–8. To overcome this previously intractable problem, we introduced a quench-cryoannealing relaxation protocol for determining n of an EPR-active trapped En turnover state. The trapped “hydride” state was allowed to relax to the resting E0 state in frozen medium, which prevents additional accumulation of reducing equivalents; binding of reduced Fe protein and release of oxidized protein from the MoFe protein both are abolished in a frozen solid. Relaxation of En was monitored by periodic EPR analysis at cryogenic temperature. The protocol rests on the hypothesis that an intermediate trapped in the frozen solid can relax toward the resting state only by the release of a stable reduction product from FeMo-co. In turnover under Ar, the only product that can be released is H2, which carries two reducing equivalents. This hypothesis implicitly predicts that states that have accumulated an odd number of electrons/protons (n = 1, 3) during turnover under Ar cannot relax to E0: E3 can relax to E1, but E1 cannot relax to E0 in the frozen state. The present experiments confirm this prediction and, thus, the quench-cryoannealing protocol and our assignment of E4, the foundation of the proposed mechanism for nitrogenase catalysis. This study further gives insights into the identity of the En intermediates with high-spin EPR signals, 1b and 1c, trapped under high electron flux. PMID:24635454

49 CFR 236.766 - Locking, movable bridge.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 4 2011-10-01 2011-10-01 false Locking, movable bridge. 236.766 Section 236.766... Locking, movable bridge. The rail locks, bridge locks, bolt locks, circuit controllers, and electric locks used in providing interlocking protection at a movable bridge. ...

Methods for removing concrete decks from bridge girders : [tech transfer summary].

DOT National Transportation Integrated Search

2014-08-01

Although bridges are typically designed to last for 75 years (AWS 2012), : bridge decks deteriorate at a faster rate (Flowers et al. 2010). Full-depth : replacement of bridge decks that can be performed without replacing the : bridge superstructures ...

2. View of Clark Fork Vehicle Bridge facing northeast. Bridge ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. View of Clark Fork Vehicle Bridge facing northeast. Bridge from south shore of Clark Fork River showing 4 1/2 spans. - Clark Fork Vehicle Bridge, Spanning Clark Fork River, serves Highway 200, Clark Fork, Bonner County, ID

7. View of Clark Fork Vehicle Bridge facing northwest. Bridge ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. View of Clark Fork Vehicle Bridge facing northwest. Bridge from south shore of Clark Fork River showing 4 1/2 spans. - Clark Fork Vehicle Bridge, Spanning Clark Fork River, serves Highway 200, Clark Fork, Bonner County, ID

Soil-structure interaction studies for understanding the behavior of integral abutment bridges.

DOT National Transportation Integrated Search

2012-03-01

Integral Abutment Bridges (IAB) are bridges without any joints within the bridge deck or between the : superstructure and the abutments. An IAB provides many advantages during construction and maintenance of : a bridge. Soil-structure interactions at...

Recommendations for design, construction, and maintenance of bridge approach slabs : synthesis report.

DOT National Transportation Integrated Search

2009-04-01

Bridge approaches provide smooth and safe transition of vehicles from highway pavements to bridge : structures. However, settlement of the bridge approach slab relative to bridge decks usually creates a : bump in the roadway. The bump causes inconven...

4. View of bridge deck from northeast approach (bridge deck ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

4. View of bridge deck from northeast approach (bridge deck from southwest approach is virtually identical - Big Cottonwood River Bridge No. 246, Spanning Big Cottonwood River at Cottonwood Street (City Road No. 165), New Ulm, Brown County, MN

BRIDGE BUILDER WILLIAM FLINN’S “CAMP & BRIDGE BUILDING OUTFIT”. INTERIOR ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

BRIDGE BUILDER WILLIAM FLINN’S “CAMP & BRIDGE BUILDING OUTFIT”. INTERIOR VIEW SHOWING LABORERS AT MEAL TIME. - Clear Fork of Brazos River Suspension Bridge, Spanning Clear Fork of Brazos River at County Route 179, Albany, Shackelford County, TX

1. VIEW OF SOUTH ELEVATION OF NOTRE DANE BRIDGE, SHOWING ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. VIEW OF SOUTH ELEVATION OF NOTRE DANE BRIDGE, SHOWING CAUSEWAY, STEEL ARCH, AND EASTBOUND LANE OF NEW BRIDGE UNDER CONSTRUCTION, PARALLELING CAUSEWAY, LOOKING NORTHWEST - Notre Dame Bridge, Spanning Merrimack River on Bridge Street, Manchester, Hillsborough County, NH

28. Under ninth bridge, view to concrete dam and eighth ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

28. Under ninth bridge, view to concrete dam and eighth bridge in background during heavy rain, view to the SW. - Vicksburg National Military Park Roads & Bridges, Melan Arch Bridges, Spanning various tributaries at Confederate Avenue, Vicksburg, Warren County, MS

49 CFR 236.766 - Locking, movable bridge.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Locking, movable bridge. 236.766 Section 236.766... Locking, movable bridge. The rail locks, bridge locks, bolt locks, circuit controllers, and electric locks used in providing interlocking protection at a movable bridge. ...

76 FR 79534 - Drawbridge Operation Regulation; New Jersey Intracoastal Waterway (NJICW), Atlantic City, NJ

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-22

.../Absecon Boulevard Bridge across Beach Thorofare, NJICW mile 67.2 and the US 40-322 (Albany Avenue) Bridge... Boulevard Bridge across Beach Thorofare, NJICW mile 67.2 and the US 40-322 (Albany Avenue) Bridge across... bridge need only open on the hour from 7 a.m. to 11 p.m. The US 40-322 (Albany Avenue Bridge) is a...

33 CFR 117.997 - Atlantic Intracoastal Waterway, South Branch of the Elizabeth River to the Albermarle and...

Code of Federal Regulations, 2010 CFR

2010-07-01

... bridge and directly beneath the bridge with closed circuit cameras mounted on top of the bridge and with... movement, a warning alarm will sound until the bridge is seated and locked down or in the full open... bridge is seated and locked down. When the bridge is seated and locked down to vessels, the channel...

Field performance of timber bridges. 5, Little Salmon Creek stress-laminated deck bridge

Treesearch

M. A. Ritter; J. A. Kainz; G. J. Porter

The Little Salmon Creek bridge was constructed in November 1988 on the Allegheny National Forest in Pennsylvania. The bridge is a simple span, single-lane, stress-laminated deck superstructure that is approximately 26-ft long and 16-ft wide. The bridge is unique in that it is the first known stress-laminated timber bridge to be constructed of hardwood lumber. The...

Foot force models of crowd dynamics on a wobbly bridge

PubMed Central

Belykh, Igor; Jeter, Russell; Belykh, Vladimir

2017-01-01

Modern pedestrian and suspension bridges are designed using industry standard packages, yet disastrous resonant vibrations are observed, necessitating multimillion dollar repairs. Recent examples include pedestrian-induced vibrations during the opening of the Solférino Bridge in Paris in 1999 and the increased bouncing of the Squibb Park Bridge in Brooklyn in 2014. The most prominent example of an unstable lively bridge is the London Millennium Bridge, which started wobbling as a result of pedestrian-bridge interactions. Pedestrian phase locking due to footstep phase adjustment is suspected to be the main cause of its large lateral vibrations; however, its role in the initiation of wobbling was debated. We develop foot force models of pedestrians’ response to bridge motion and detailed, yet analytically tractable, models of crowd phase locking. We use biomechanically inspired models of crowd lateral movement to investigate to what degree pedestrian synchrony must be present for a bridge to wobble significantly and what is a critical crowd size. Our results can be used as a safety guideline for designing pedestrian bridges or limiting the maximum occupancy of an existing bridge. The pedestrian models can be used as “crash test dummies” when numerically probing a specific bridge design. This is particularly important because the U.S. code for designing pedestrian bridges does not contain explicit guidelines that account for the collective pedestrian behavior. PMID:29296679

Foot force models of crowd dynamics on a wobbly bridge.

PubMed

Belykh, Igor; Jeter, Russell; Belykh, Vladimir

2017-11-01

Modern pedestrian and suspension bridges are designed using industry standard packages, yet disastrous resonant vibrations are observed, necessitating multimillion dollar repairs. Recent examples include pedestrian-induced vibrations during the opening of the Solférino Bridge in Paris in 1999 and the increased bouncing of the Squibb Park Bridge in Brooklyn in 2014. The most prominent example of an unstable lively bridge is the London Millennium Bridge, which started wobbling as a result of pedestrian-bridge interactions. Pedestrian phase locking due to footstep phase adjustment is suspected to be the main cause of its large lateral vibrations; however, its role in the initiation of wobbling was debated. We develop foot force models of pedestrians' response to bridge motion and detailed, yet analytically tractable, models of crowd phase locking. We use biomechanically inspired models of crowd lateral movement to investigate to what degree pedestrian synchrony must be present for a bridge to wobble significantly and what is a critical crowd size. Our results can be used as a safety guideline for designing pedestrian bridges or limiting the maximum occupancy of an existing bridge. The pedestrian models can be used as "crash test dummies" when numerically probing a specific bridge design. This is particularly important because the U.S. code for designing pedestrian bridges does not contain explicit guidelines that account for the collective pedestrian behavior.

An improved bridge safety index for narrow bridges.

DOT National Transportation Integrated Search

1983-08-01

In this report, a new bridge safety index is developed based upon an extensive : statistical study of accident data on 78 bridges. A total of 655 accidents : were recorded at these bridges over the six-year period between 1974 and 1979. : Cluster ana...

Update of bridge design standards in Alabama for AASHTO LRFD seismic design requirements.

DOT National Transportation Integrated Search

2013-11-01

The Alabama Department of Transportation (ALDOT) has been required to update their bridge design to the LRFD Bridge Design Specifications. This transition has resulted in changes to the seismic design standards of bridges in the state. Multiple bridg...

Precast alternative for flat slab bridges : final report.

DOT National Transportation Integrated Search

2013-10-26

The cast-in-place (CIP) concrete slab bridge and the hollow core flat slab bridge are two very common bridge types utilized by the : South Carolina Department of Transportation (SCDOT). The CIP bridge is durable but has a long construction time while...

Vehicle - Bridge interaction, comparison of two computing models

NASA Astrophysics Data System (ADS)

Melcer, Jozef; Kuchárová, Daniela

2017-07-01

The paper presents the calculation of the bridge response on the effect of moving vehicle moves along the bridge with various velocities. The multi-body plane computing model of vehicle is adopted. The bridge computing models are created in two variants. One computing model represents the bridge as the Bernoulli-Euler beam with continuously distributed mass and the second one represents the bridge as the lumped mass model with 1 degrees of freedom. The mid-span bridge dynamic deflections are calculated for both computing models. The results are mutually compared and quantitative evaluated.

A Sterile 20 Family Kinase and Its Co-factor CCM-3 Regulate Contractile Ring Proteins on Germline Intercellular Bridges.

PubMed

Rehain-Bell, Kathryn; Love, Andrew; Werner, Michael E; MacLeod, Ian; Yates, John R; Maddox, Amy Shaub

2017-03-20

Germ cells in most animals are connected by intercellular bridges, actin-based rings that form stable cytoplasmic connections between cells promoting communication and coordination [1]. Moreover, these connections are required for fertility [1, 2]. Intercellular bridges are proposed to arise from stabilization of the cytokinetic ring during incomplete cytokinesis [1]. Paradoxically, proteins that promote closure of cytokinetic rings are enriched on stably open intercellular bridges [1, 3, 4]. Given this inconsistency, the mechanism of intercellular bridge stabilization is unclear. Here, we used the C. elegans germline as a model for identifying molecular mechanisms regulating intercellular bridges. We report that bridges are actually highly dynamic, changing size at precise times during germ cell development. We focused on the regulation of bridge stability by anillins, key regulators of cytokinetic rings and cytoplasmic bridges [1, 4-7]. We identified GCK-1, a conserved serine/threonine kinase [8], as a putative novel anillin interactor. GCK-1 works together with CCM-3, a known binding partner [9], to promote intercellular bridge stability and limit localization of both canonical anillin and non-muscle myosin II (NMM-II) to intercellular bridges. Additionally, we found that a shorter anillin, known to stabilize bridges [4, 7], also regulates NMM-II levels at bridges. Consistent with these results, negative regulators of NMM-II stabilize intercellular bridges in the Drosophila egg chamber [10, 11]. Together with our findings, this suggests that tuning of myosin levels is a conserved mechanism for the stabilization of intercellular bridges that can occur by diverse molecular mechanisms. Copyright © 2017 Elsevier Ltd. All rights reserved.

Diode-quad bridge circuit means

NASA Technical Reports Server (NTRS)

Harrison, D. R.; Dimeff, J. (Inventor)

1975-01-01

Diode-quad bridge circuit means is described for use as a transducer circuit or as a discriminator circuit. It includes: (1) a diode bridge having first, second, third, and fourth bridge terminals consecutively coupled together by four diodes polarized in circulating relationship; (2) a first impedance connected between the second bridge terminal and a circuit ground; (3) a second impedance connected between the fourth bridge terminal and the circuit ground; (4) a signal source having a first source terminal capacitively coupled to the first and third bridge terminals, and a second source terminal connected to the circuit ground; and (5) an output terminal coupled to the first bridge terminal and at which an output signal may be taken.

Characterization of stormwater runoff from bridges in North Carolina and the effects of bridge runoff on receiving streams

USGS Publications Warehouse

Wagner, Chad; Fitzgerald, Sharon; Lauffer, Matthew

2015-01-01

The presentation will provide an overview of a collaborative study between USGS, NC Department of Transportation and URS Corporation to characterize stormwater runoff from bridges in North Carolina and the effects of bridge runoff on receiving streams. This investigation measured bridge deck runoff from 15 bridges for 12-15 storms, stream water-quality data for baseflow and storm conditions at four of the bridge deck sites and streambed sediment chemistry upstream and downstream of 30 bridges across North Carolina. Background on why the study was conducted, objectives and scope and a general summary of the major results and conclusions will be presented.

U.S. Geological Survey - Virginia Department of Transportation: Bridge scour pilot study

USGS Publications Warehouse

Austin, Samuel H.

2018-02-27

BackgroundCost effective and safe highway bridge designs are required to ensure the long-term sustainability of Virginia’s road systems. The streamflows that, over time, scour streambed sediments from bridge piers inherently affect bridge safety and design costs. To ensure safety, bridge design must anticipate streambed scour at bridge piers over the lifespan of a bridge. Until recently Federal Highway Administration (FHWA) guidance provided only for scour estimates of granular, noncohesive, highly erosive material yielding overestimates of scour potential in instances when streambed materials offer some resistance to scour. This study seeks to estimate stream power and streambed scour for these more resistive sites, with bridge piers potentially established in cohesive soil or erodible rock. This new knowledge may provide significant construction cost savings while ensuring design and construction of safe highway bridges.

49 CFR 237.55 - Railroad bridge supervisors.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 4 2011-10-01 2011-10-01 false Railroad bridge supervisors. 237.55 Section 237.55..., DEPARTMENT OF TRANSPORTATION BRIDGE SAFETY STANDARDS Qualifications and Designations of Responsible Persons § 237.55 Railroad bridge supervisors. A railroad bridge supervisor shall be a person, regardless of...

23 CFR 650.407 - Application for bridge replacement or rehabilitation.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 23 Highways 1 2011-04-01 2011-04-01 false Application for bridge replacement or rehabilitation... ENGINEERING AND TRAFFIC OPERATIONS BRIDGES, STRUCTURES, AND HYDRAULICS Highway Bridge Replacement and Rehabilitation Program § 650.407 Application for bridge replacement or rehabilitation. (a) Agencies participate...

23 CFR 650.411 - Procedures for bridge replacement and rehabilitation projects.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 23 Highways 1 2011-04-01 2011-04-01 false Procedures for bridge replacement and rehabilitation... ENGINEERING AND TRAFFIC OPERATIONS BRIDGES, STRUCTURES, AND HYDRAULICS Highway Bridge Replacement and Rehabilitation Program § 650.411 Procedures for bridge replacement and rehabilitation projects. (a) Consideration...

Seismic evaluation of the Tennessee River Bridges on Interstate 24 in Western Kentucky.

DOT National Transportation Integrated Search

2006-09-01

This report presents the seismic evaluation of the approaches and parallel bridges on I-24 crossing the Tennessee River between Marshall and Livingston counties in Western Kentucky. The main bridges are steel tied-arch bridges. The bridges are situat...

NYSDOT Bridge Deck Task Force evaluation of bridge deck cracking on NYSDOT bridges

DOT National Transportation Integrated Search

2007-02-01

This paper presents a summary of knowledge gained by the NYSDOT Bridge Deck Task Force (BDTF). Although the paper contains recommendations to reduce the prevalence and severity of bridge deck cracking, it does not include a silver bullet soluti...

23 CFR 650.411 - Procedures for bridge replacement and rehabilitation projects.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 23 Highways 1 2010-04-01 2010-04-01 false Procedures for bridge replacement and rehabilitation... ENGINEERING AND TRAFFIC OPERATIONS BRIDGES, STRUCTURES, AND HYDRAULICS Highway Bridge Replacement and Rehabilitation Program § 650.411 Procedures for bridge replacement and rehabilitation projects. (a) Consideration...

33 CFR 116.30 - Administrator, Bridge Administration Program Review and Evaluation.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Administrator, Bridge..., DEPARTMENT OF HOMELAND SECURITY BRIDGES ALTERATION OF UNREASONABLY OBSTRUCTIVE BRIDGES § 116.30 Administrator, Bridge Administration Program Review and Evaluation. (a) Upon receiving a Detailed Investigation Report...

49 CFR 237.55 - Railroad bridge supervisors.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Railroad bridge supervisors. 237.55 Section 237.55..., DEPARTMENT OF TRANSPORTATION BRIDGE SAFETY STANDARDS Qualifications and Designations of Responsible Persons § 237.55 Railroad bridge supervisors. A railroad bridge supervisor shall be a person, regardless of...

23 CFR 650.407 - Application for bridge replacement or rehabilitation.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 23 Highways 1 2010-04-01 2010-04-01 false Application for bridge replacement or rehabilitation... ENGINEERING AND TRAFFIC OPERATIONS BRIDGES, STRUCTURES, AND HYDRAULICS Highway Bridge Replacement and Rehabilitation Program § 650.407 Application for bridge replacement or rehabilitation. (a) Agencies participate...

77 FR 16784 - General Bridge Regulation; Amendment

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-22

...] RIN 1625-AB36 General Bridge Regulation; Amendment AGENCY: Coast Guard, DHS. ACTION: Proposed rule... bridge regulations. The rulemaking was initiated to clarify the statutory responsibilities of bridge owners to remove their bridges from navigable waterways when they are no longer being used for land...

Research and development of weathering resistant bridge steel of Shougang

NASA Astrophysics Data System (ADS)

Yang, Yongda; Wang, Yanfeng; Huang, Leqing; Di, Guobiao; Ma, Changwen; Ma, Qingshen

2017-09-01

To introduce the composition design and mechanical properties and microstructure of the weathering bridge steel which would be used for bridge of Guanting reservoir. We adopt cyclic immersion corrosion test to study corrosion resistance difference of weathering bridge steel and common bridge steel. At the same corrosion time, the weight loss and corrosion rate of weathering bridge steel are lower than the common bridge steel's. Testing phase composition of rust layer by X-ray diffraction, two kinds of test steel's rust layer is mainly composed of Goethite and Fe3O4 and Fe2O3. At the same corrosion time, the percentage composition of goethite in rust layer of weathering bridge steel are significantly higher than common bridge steel's, the higher goethite content is, the compacter rust layer structure is. The compact rust layer would prevent the water and air passing the rust layer, and then preventing the further corrosion reaction, improving the corrosion resistance performance of weathering bridge steel.

Seismic Retrofitting of an Existing Steel Railway Bridge by Fluid Viscous Dampers

NASA Astrophysics Data System (ADS)

Gangopadhyay, Avijit; Ghosh, Aparna Dey

2016-09-01

There are over a lakh of bridges in the Indian Railways, many of which have become seismically deficient, either through aging or due to inadequate seismic design considerations. The extensive damage of bridges all over the world in recent earthquakes has propelled significant advancement in earthquake protection and retrofitting of bridges. Amongst various passive control systems that are reliable as well as cost-effective, Fluid Viscous Dampers (FVDs) are proving to be successful in bridge vibration control. Orificed FVDs, commercially available as Taylor Devices, have already been successfully installed in several bridges worldwide. However, there has been no such application or study related to Indian railway bridges. In this paper, an existing thirty years' old railway bridge in Jharkhand, India, has been analyzed in SAP2000v14 considering reduced stiffness and found deficient when subjected to spectrum-compatible accelerograms. Subsequent retrofitting of the bridge superstructure with FVDs has been carried out and the results indicate substantial reductions in the responses of the bridge deck.

23 CFR 661.35 - What percentage of IRRBP funding is available for use on BIA and Tribally owned IRR bridges, and...

Code of Federal Regulations, 2011 CFR

2011-04-01

... BIA and Tribally owned IRR bridges, and non-BIA owned IRR bridges? 661.35 Section 661.35 Highways... RESERVATION ROAD BRIDGE PROGRAM § 661.35 What percentage of IRRBP funding is available for use on BIA and Tribally owned IRR bridges, and non-BIA owned IRR bridges? (a) Up to 80 percent of the available funding...

Field performance of timber bridges. 9, Big Erick`s stress-laminated deck bridge

Treesearch

J. A. Kainz; J. P. Wacker; M. Nelson

The Big Erickas bridge was constructed during September 1992 in Baraga County, Michigan. The bridge is 72 ft long, 16 ft wide, and consists of three simple spans: two stress-laminated deck approach spans and a stress-laminated box center span. The bridge is unique in that it is one of the first known stress-laminated timber bridge applications to use Eastern Hemlock...

Development of inspection robots for bridge cables.

PubMed

Yun, Hae-Bum; Kim, Se-Hoon; Wu, Liuliu; Lee, Jong-Jae

2013-01-01

This paper presents the bridge cable inspection robot developed in Korea. Two types of the cable inspection robots were developed for cable-suspension bridges and cable-stayed bridge. The design of the robot system and performance of the NDT techniques associated with the cable inspection robot are discussed. A review on recent advances in emerging robot-based inspection technologies for bridge cables and current bridge cable inspection methods is also presented.

23 CFR 661.35 - What percentage of IRRBP funding is available for use on BIA and Tribally owned IRR bridges, and...

Code of Federal Regulations, 2010 CFR

2010-04-01

... BIA and Tribally owned IRR bridges, and non-BIA owned IRR bridges? 661.35 Section 661.35 Highways... RESERVATION ROAD BRIDGE PROGRAM § 661.35 What percentage of IRRBP funding is available for use on BIA and Tribally owned IRR bridges, and non-BIA owned IRR bridges? (a) Up to 80 percent of the available funding...

NPSNET: Dynamic Terrain and Cultured Feature Depiction

DTIC Science & Technology

1992-09-01

defaults. bridge(terrain *ptr, vertex pos, bridge mattype bmat ); This constructor takes only the pointer to the underlying terrain, a placement, and a...material to use for construction. bridge(terrain *ptr, vertex pos, bridge-mattype bmat , float dir); This constructor takes a terrain pointer, a...placement position, a material to use, and a direction to run. bridge(terrain *ptr, vertex pos, bridge-mattype bmat , float dir, float width, float height

Hydraulic modeling of flow impact on bridge structures: a case study on Citarum bridge

NASA Astrophysics Data System (ADS)

Siregar, R. I.

2018-02-01

Flood waves because of the rapid catchment response to high intense rainfall, breaches of flood defenses may induce huge impact forces on structures, causing structural damage or even failures. Overflowing stream that passes over the bridge, it means to discharge flood water level is smaller than the capacity of the river flow. In this study, the researches present the methodological approach of flood modeling on bridge structures. The amount of force that obtained because of the hydrostatic pressure received by the bridge at the time of the flood caused the bridge structure disrupted. This paper presents simulation of flow impact on bridge structures with some event flood conditions. Estimating the hydrostatic pressure developed new model components, to quantify the flow impact on structures. Flow parameters applied the model for analyzing, such as discharge, velocity, and water level or head that effect of bridge structures. The simulation will illustrate the capability of bridge structures with some event flood river and observe the behavior of the flow that occurred during the flood. Hydraulic flood modeling use HEC-RAS for simulation. This modeling will describe the impact on bridge structures. Based on the above modelling resulted, in 2008 has flood effect more than other years on the Citarum Bridge, because its flow overflow on the bridge.

Wireless Smart Sensor Network System Using SmartBridge Sensor Nodes for Structural Health Monitoring of Existing Concrete Bridges

NASA Astrophysics Data System (ADS)

Gaviña, J. R.; Uy, F. A.; Carreon, J. D.

2017-06-01

There are over 8000 bridges in the Philippines today according to the Department of Public Works and Highways (DPWH). Currently, visual inspection is the most common practice in monitoring the structural integrity of bridges. However, visual inspections have proven to be insufficient in determining the actual health or condition of a bridge. Structural Health Monitoring (SHM) aims to give, in real-time, a diagnosis of the actual condition of the bridge. In this study, SmartBridge Sensor Nodes were installed on an existing concrete bridge with American Association of State Highway and Transportation Officials (AASHTO) Type IV Girders to gather vibration of the elements of the bridge. Also, standards on the effective installation of SmartBridge Sensor Nodes, such as location and orientation was determined. Acceleration readings from the sensor were then uploaded to a server, wherein they are monitored against certain thresholds, from which, the health of the bridge will be derived. Final output will be a portal or webpage wherein the information, health, and acceleration readings of the bridge will be available for viewing. With levels of access set for different types of users, the main users will have access to download data and reports. Data transmission and webpage access are available online, making the SHM system wireless.

A Bridge to Active Learning: A Summer Bridge Program Helps Students Maximize Their Active-Learning Experiences and the Active-Learning Experiences of Others

PubMed Central

Cooper, Katelyn M.; Ashley, Michael; Brownell, Sara E.

2017-01-01

National calls to improve student academic success in college have sparked the development of bridge programs designed to help students transition from high school to college. We designed a 2-week Summer Bridge program that taught introductory biology content in an active-learning way. Through a set of exploratory interviews, we unexpectedly identified that Bridge students had developed sophisticated views of active learning, even though this was not an explicit goal of the program. We conducted an additional set of semistructured interviews that focused on active learning and compared the interviews of Bridge students with those from non-Bridge students who had been eligible for but did not participate in the program. We used the constant comparative method to identify themes from the interviews. We found that Bridge students perceived that, because they knew how to approach active learning and viewed it as important, they benefited more from active learning in introductory biology than non-Bridge students. Specifically, Bridge students seemed to be more aware of their own learning gains from participating in active learning. Compared with the majority of non-Bridge students, the majority of Bridge students described using a greater variety of strategies to maximize their experiences in active learning. Finally, in contrast to non-Bridge students, Bridge students indicated that they take an equitable approach to group work. These findings suggest that we may be able to prime students to maximize their own and other’s experiences in active learning. PMID:28232588

Stabilization of electrically conducting capillary bridges using feedback control of radial electrostatic stresses and the shapes of extended bridges

NASA Astrophysics Data System (ADS)

Marr-Lyon, Mark J.; Thiessen, David B.; Blonigen, Florian J.; Marston, Philip L.

2000-05-01

Electrically conducting, cylindrical liquid bridges in a density-matched, electrically insulating bath were stabilized beyond the Rayleigh-Plateau (RP) limit using electrostatic stresses applied by concentric ring electrodes. A circular liquid cylinder of length L and radius R in real or simulated zero gravity becomes unstable when the slenderness S=L/2R exceeds π. The initial instability involves the growth of the so-called (2, 0) mode of the bridge in which one side becomes thin and the other side rotund. A mode-sensing optical system detects the growth of the (2, 0) mode and an analog feedback system applies the appropriate voltages to a pair of concentric ring electrodes positioned near the ends of the bridge in order to counter the growth of the (2, 0) mode and prevent breakup of the bridge. The conducting bridge is formed between metal disks which are grounded. Three feedback algorithms were tested and each found capable of stabilizing a bridge well beyond the RP limit. All three algorithms stabilized bridges having S as great as 4.3 and the extended bridges broke immediately when feedback was terminated. One algorithm was suitable for stabilization approaching S=4.493… where the (3, 0) mode is predicted to become unstable for cylindrical bridges. For that algorithm the equilibrium shapes of bridges that were slightly under or over inflated corresponded to solutions of the Young-Laplace equation with negligible electrostatic stresses. The electrical conductivity of the bridge liquid need not be large. The conductivity was associated with salt added to the aqueous bridge liquid.

Chromosome Bridges Maintain Kinetochore-Microtubule Attachment throughout Mitosis and Rarely Break during Anaphase.

PubMed

Pampalona, Judit; Roscioli, Emanuele; Silkworth, William T; Bowden, Brent; Genescà, Anna; Tusell, Laura; Cimini, Daniela

2016-01-01

Accurate chromosome segregation during cell division is essential to maintain genome stability, and chromosome segregation errors are causally linked to genetic disorders and cancer. An anaphase chromosome bridge is a particular chromosome segregation error observed in cells that enter mitosis with fused chromosomes/sister chromatids. The widely accepted Breakage/Fusion/Bridge cycle model proposes that anaphase chromosome bridges break during mitosis to generate chromosome ends that will fuse during the following cell cycle, thus forming new bridges that will break, and so on. However, various studies have also shown a link between chromosome bridges and aneuploidy and/or polyploidy. In this study, we investigated the behavior and properties of chromosome bridges during mitosis, with the idea to gain insight into the potential mechanism underlying chromosome bridge-induced aneuploidy. We find that only a small number of chromosome bridges break during anaphase, whereas the rest persist through mitosis into the subsequent cell cycle. We also find that the microtubule bundles (k-fibers) bound to bridge kinetochores are not prone to breakage/detachment, thus supporting the conclusion that k-fiber detachment is not the cause of chromosome bridge-induced aneuploidy. Instead, our data suggest that while the microtubules bound to the kinetochores of normally segregating chromosomes shorten substantially during anaphase, the k-fibers bound to bridge kinetochores shorten only slightly, and may even lengthen, during anaphase. This causes some of the bridge kinetochores/chromosomes to lag behind in a position that is proximal to the cell/spindle equator and may cause the bridged chromosomes to be segregated into the same daughter nucleus or to form a micronucleus.

Salt-Bridge Energetics in Halophilic Proteins

PubMed Central

Nayek, Arnab; Sen Gupta, Parth Sarthi; Banerjee, Shyamashree; Mondal, Buddhadev; Bandyopadhyay, Amal K.

2014-01-01

Halophilic proteins have greater abundance of acidic over basic and very low bulky hydrophobic residues. Classical electrostatic stabilization was suggested as the key determinant for halophilic adaptation of protein. However, contribution of specific electrostatic interactions (i.e. salt-bridges) to overall stability of halophilic proteins is yet to be understood. To understand this, we use Adaptive-Poison-Boltzmann-Solver Methods along with our home-built automation to workout net as well as associated component energy terms such as desolvation energy, bridge energy and background energy for 275 salt-bridges from 20 extremely halophilic proteins. We then perform extensive statistical analysis on general and energetic attributes on these salt-bridges. On average, 8 salt-bridges per 150 residues protein were observed which is almost twice than earlier report. Overall contributions of salt-bridges are −3.0 kcal mol−1. Majority (78%) of salt-bridges in our dataset are stable and conserved in nature. Although, average contributions of component energy terms are equal, their individual details vary greatly from one another indicating their sensitivity to local micro-environment. Notably, 35% of salt-bridges in our database are buried and stable. Greater desolvation penalty of these buried salt-bridges are counteracted by stable network salt-bridges apart from favorable equal contributions of bridge and background terms. Recruitment of extensive network salt-bridges (46%) with a net contribution of −5.0 kcal mol−1 per salt-bridge, seems to be a halophilic design wherein favorable average contribution of background term (−10 kcal mol−1) exceeds than that of bridge term (−7 kcal mol−1). Interiors of proteins from halophiles are seen to possess relatively higher abundance of charge and polar side chains than that of mesophiles which seems to be satisfied by cooperative network salt-bridges. Overall, our theoretical analyses provide insight into halophilic signature in its specific electrostatic interactions which we hope would help in protein engineering and bioinformatics studies. PMID:24743799

Salt-bridge energetics in halophilic proteins.

PubMed

Nayek, Arnab; Sen Gupta, Parth Sarthi; Banerjee, Shyamashree; Mondal, Buddhadev; Bandyopadhyay, Amal K

2014-01-01

Halophilic proteins have greater abundance of acidic over basic and very low bulky hydrophobic residues. Classical electrostatic stabilization was suggested as the key determinant for halophilic adaptation of protein. However, contribution of specific electrostatic interactions (i.e. salt-bridges) to overall stability of halophilic proteins is yet to be understood. To understand this, we use Adaptive-Poison-Boltzmann-Solver Methods along with our home-built automation to workout net as well as associated component energy terms such as desolvation energy, bridge energy and background energy for 275 salt-bridges from 20 extremely halophilic proteins. We then perform extensive statistical analysis on general and energetic attributes on these salt-bridges. On average, 8 salt-bridges per 150 residues protein were observed which is almost twice than earlier report. Overall contributions of salt-bridges are -3.0 kcal mol-1. Majority (78%) of salt-bridges in our dataset are stable and conserved in nature. Although, average contributions of component energy terms are equal, their individual details vary greatly from one another indicating their sensitivity to local micro-environment. Notably, 35% of salt-bridges in our database are buried and stable. Greater desolvation penalty of these buried salt-bridges are counteracted by stable network salt-bridges apart from favorable equal contributions of bridge and background terms. Recruitment of extensive network salt-bridges (46%) with a net contribution of -5.0 kcal mol-1 per salt-bridge, seems to be a halophilic design wherein favorable average contribution of background term (-10 kcal mol-1) exceeds than that of bridge term (-7 kcal mol-1). Interiors of proteins from halophiles are seen to possess relatively higher abundance of charge and polar side chains than that of mesophiles which seems to be satisfied by cooperative network salt-bridges. Overall, our theoretical analyses provide insight into halophilic signature in its specific electrostatic interactions which we hope would help in protein engineering and bioinformatics studies.

33 CFR 115.60 - Procedures for handling applications for bridge construction permits.

Code of Federal Regulations, 2011 CFR

2011-07-01

... applications for bridge construction permits. 115.60 Section 115.60 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES BRIDGE LOCATIONS AND CLEARANCES; ADMINISTRATIVE PROCEDURES § 115.60 Procedures for handling applications for bridge construction permits. The following procedures will be...

33 CFR 118.140 - Painting bridge piers.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Painting bridge piers. 118.140 Section 118.140 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES BRIDGE LIGHTING AND OTHER SIGNALS § 118.140 Painting bridge piers. The District Commander may require...

23 CFR 650.705 - Application for discretionary bridge funds.

Code of Federal Regulations, 2011 CFR

2011-04-01

... 23 Highways 1 2011-04-01 2011-04-01 false Application for discretionary bridge funds. 650.705... TRAFFIC OPERATIONS BRIDGES, STRUCTURES, AND HYDRAULICS Discretionary Bridge Candidate Rating Factor § 650.705 Application for discretionary bridge funds. Each year through its field offices, the FHWA will...

49 CFR 237.53 - Railroad bridge inspectors.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 4 2011-10-01 2011-10-01 false Railroad bridge inspectors. 237.53 Section 237.53..., DEPARTMENT OF TRANSPORTATION BRIDGE SAFETY STANDARDS Qualifications and Designations of Responsible Persons § 237.53 Railroad bridge inspectors. A railroad bridge inspector shall be a person who is determined by...

23 CFR 650.307 - Bridge inspection organization.

Code of Federal Regulations, 2010 CFR

2010-04-01

... bridges located on public roads that are fully or partially located within the State's boundaries, except... inspected, all highway bridges located on public roads that are fully or partially located within the... preparation and maintenance of a bridge inventory. (2) Bridge inspections, reports, load ratings and other...

OLD SUSPENSION BRIDGE. This view appears to be looking southeast, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

OLD SUSPENSION BRIDGE. This view appears to be looking southeast, at the downstream side of the suspension bridge, which was replaced by the South Fork Trinity River Bridge - South Fork Trinity River Bridge, State Highway 299 spanning South Fork Trinity River, Salyer, Trinity County, CA

Evaluation of the need for longitudinal median joints in bridge decks on dual structures.

DOT National Transportation Integrated Search

2015-09-01

The primary objective of this project was to determine the effect of bridge width on deck cracking in bridges. Other parameters, : such as bridge skew, girder spacing and type, abutment type, pier type, and number of bridge spans, were also studied. ...

Advanced bridge safety initiative : FRP flexural retrofit for concrete slab bridges - task 4 deliverables.

DOT National Transportation Integrated Search

2014-06-01

Concrete slab bridges are being examined as part of the MaineDOT Advanced Bridge Safety Initiative. Under Tasks : 1 3 a finite element analysis program is developed, validated and applied to twenty bridges. : Task 4 investigates and develops a no...

Field Performance of Timber Bridges. 16: North Siwell Road Stress-Laminated Bridge

DOT National Transportation Integrated Search

1998-03-01

This report is 16th in a series of reports that documents the : field performance of timber bridges. The North Siwell Road bridge was constructed during December 1994 in Hinds County, Mississippi. The bridge is a single span, stress laminated T-beam ...

6. VIEW OF GDOT BRIDGE NO. 02700268X00678N BRIDGE PLATE IDENTIFYING ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

6. VIEW OF GDOT BRIDGE NO. 027-00268X-00678N BRIDGE PLATE IDENTIFYING COUNTY COMMISSIONERS AT THE TIME OF CONSTRUCTION. - GDOT Bridge No. 027-00268X-00678N, County Road 268-Empress Road span Piscola Creek, Quitman, Brooks County, GA

Hierarchical analysis of bridge decision makers : the role of new technology adoption in the timber bridge market : special project fiscal year 1992

DOT National Transportation Integrated Search

1995-08-01

Bridge design engineers and local highway officials make bridge replacement decisions across the : United States. The Analytical Hierarchy Process was used to characterize the bridge material selection : decision of these individuals. State Departmen...

76 FR 55160 - Annual Materials Report on New Bridge Construction and Bridge Rehabilitation

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-06

... DEPARTMENT OF TRANSPORTATION Federal Highway Administration Annual Materials Report on New Bridge Construction and Bridge Rehabilitation AGENCY: Federal Highway Administration (FHWA), DOT. ACTION: Notice... for Users (SAFETEA-LU) (Pub. L. 109-59; 119 Stat. 1144) continued the highway bridge program to enable...

23 CFR 650.705 - Application for discretionary bridge funds.

Code of Federal Regulations, 2010 CFR

2010-04-01

... 23 Highways 1 2010-04-01 2010-04-01 false Application for discretionary bridge funds. 650.705... TRAFFIC OPERATIONS BRIDGES, STRUCTURES, AND HYDRAULICS Discretionary Bridge Candidate Rating Factor § 650.705 Application for discretionary bridge funds. Each year through its field offices, the FHWA will...

33 CFR 118.140 - Painting bridge piers.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Painting bridge piers. 118.140 Section 118.140 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES BRIDGE LIGHTING AND OTHER SIGNALS § 118.140 Painting bridge piers. The District Commander may require...

49 CFR 237.53 - Railroad bridge inspectors.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Railroad bridge inspectors. 237.53 Section 237.53..., DEPARTMENT OF TRANSPORTATION BRIDGE SAFETY STANDARDS Qualifications and Designations of Responsible Persons § 237.53 Railroad bridge inspectors. A railroad bridge inspector shall be a person who is determined by...

77 FR 53251 - Annual Materials Report on New Bridge Construction and Bridge Rehabilitation

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-31

... DEPARTMENT OF TRANSPORTATION Federal Highway Administration Annual Materials Report on New Bridge Construction and Bridge Rehabilitation AGENCY: Federal Highway Administration (FHWA), DOT. ACTION: Notice... for Users (SAFETEA-LU) (Pub. L. 109-59; 119 Stat. 1144) continued the highway bridge program to enable...

33 CFR 115.60 - Procedures for handling applications for bridge construction permits.

Code of Federal Regulations, 2010 CFR

2010-07-01

... applications for bridge construction permits. 115.60 Section 115.60 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES BRIDGE LOCATIONS AND CLEARANCES; ADMINISTRATIVE PROCEDURES § 115.60 Procedures for handling applications for bridge construction permits. The following procedures will be...

75 FR 62181 - Annual Materials Report on New Bridge Construction and Bridge Rehabilitation

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-07

... DEPARTMENT OF TRANSPORTATION Federal Highway Administration Annual Materials Report on New Bridge Construction and Bridge Rehabilitation AGENCY: Federal Highway Administration (FHWA), DOT. ACTION: Notice... for Users (SAFETEA-LU) (Pub. L. 109-59; 119 Stat. 1144) continued the highway bridge program to enable...

Bridges Dynamic Parameters Identification Based On Experimental and Numerical Method Comparison in Regard with Traffic Seismicity

NASA Astrophysics Data System (ADS)

Krkošková, Katarína; Papán, Daniel; Papánová, Zuzana

2017-10-01

The technical seismicity negatively affects the environment, buildings and structures. Technical seismicity means seismic shakes caused by force impulse, random process and unnatural origin. The vibration influence on buildings is evaluated in the Eurocode 8 in Slovak Republic, however, the Slovak Technical Standard STN 73 0036 includes solution of the technical seismicity. This standard also classes bridges into the group of structures that are significant in light of the technical seismicity - the group “U”. Using the case studies analysis by FEM simulation and comparison is necessary because of brief norm evaluation of this issue. In this article, determinate dynamic parameters by experimental measuring and numerical method on two real bridges are compared. First bridge, (D201 - 00) is Scaffold Bridge on the road I/11 leading to the city of Čadca and is situated in the city of Žilina. It is eleven - span concrete road bridge. The railway is the obstacle, which this bridge spans. Second bridge (M5973 Brodno) is situated in the part of Žilina City on the road of I/11. It is concrete three - span road bridge built as box girder. The computing part includes 3D computational models of the bridges. First bridge (D201 - 00) was modelled in the software of IDA Nexis as the slab - wall model. The model outputs are natural frequencies and natural vibration modes. Second bridge (M5973 Brodno) was modelled in the software of VisualFEA. The technical seismicity corresponds with the force impulse, which was put into this model. The model outputs are vibration displacements, velocities and accelerations. The aim of the experiments was measuring of the vibration acceleration time record of bridges, and there was need to systematic placement of accelerometers. The vibration acceleration time record is important during the under - bridge train crossing, about the first bridge (D201 - 00) and the vibration acceleration time domain is important during deducing the force impulse under the bridge, about second bridge (M5973 Brodno). The analysis was done in the software of Sigview. About the first bridge (D201 - 00), the analysis output were values of power spectral density adherent to the frequencies values. These frequencies were compared with the natural frequencies values from the computational model whereby the technical seismicity influence on bridge natural frequencies was found out. About the second bridge (M5973 Brodno), the Sigview display of recorded vibration velocity time history was compared with the final vibration velocity time history from the computational model, whereby the results were incidental.

46 CFR 113.35-17 - Vessels with navigating bridge control.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 46 Shipping 4 2011-10-01 2011-10-01 false Vessels with navigating bridge control. 113.35-17... bridge control. Each vessel with navigating bridge throttle control must have a positive mechanical stop on each telegraph transmitter that prevents movement to the “Navigating Bridge Control” position...

49 CFR 237.71 - Determination of bridge load capacities.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 4 2011-10-01 2011-10-01 false Determination of bridge load capacities. 237.71... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION BRIDGE SAFETY STANDARDS Capacity of Bridges § 237.71 Determination of bridge load capacities. (a) Each track owner shall determine the load capacity of each of its...

49 CFR 236.312 - Movable bridge, interlocking of signal appliances with bridge devices.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 4 2011-10-01 2011-10-01 false Movable bridge, interlocking of signal appliances with bridge devices. 236.312 Section 236.312 Transportation Other Regulations Relating to... SYSTEMS, DEVICES, AND APPLIANCES Interlocking Standards § 236.312 Movable bridge, interlocking of signal...

33 CFR 116.30 - Administrator, Office of Bridge Programs Review and Evaluation.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Administrator, Office of Bridge..., DEPARTMENT OF HOMELAND SECURITY BRIDGES ALTERATION OF UNREASONABLY OBSTRUCTIVE BRIDGES § 116.30 Administrator, Office of Bridge Programs Review and Evaluation. (a) Upon receiving a Detailed Investigation Report from...

25 CFR 170.507 - Who reviews bridge inspection reports?

Code of Federal Regulations, 2011 CFR

2011-04-01

... 25 Indians 1 2011-04-01 2011-04-01 false Who reviews bridge inspection reports? 170.507 Section... ROADS PROGRAM Planning, Design, and Construction of Indian Reservation Roads Program Facilities Bridge Inspection § 170.507 Who reviews bridge inspection reports? The person responsible for the bridge inspection...

33 CFR 115.30 - Sufficiency of State authority for bridges.

Code of Federal Regulations, 2011 CFR

2011-07-01

... for bridges. 115.30 Section 115.30 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES BRIDGE LOCATIONS AND CLEARANCES; ADMINISTRATIVE PROCEDURES § 115.30 Sufficiency of State authority for bridges. An opinion of the attorney general of the State as to the sufficiency of State...

14. Fifth Melan Bridge on tour route, Union Avenue near ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

14. Fifth Melan Bridge on tour route, Union Avenue near Park Boundary, elevation view to the north, showing Culvert beyond park boundary. (bridge has now been replaced with box culvert). - Vicksburg National Military Park Roads & Bridges, Melan Arch Bridges, Spanning various tributaries at Confederate Avenue, Vicksburg, Warren County, MS

Sensitivity analysis of bridge health index to element failure and element conditions.

DOT National Transportation Integrated Search

2009-11-01

Bridge Health Index (BHI) is a bridge performance measure based on the condition of the bridge elements. It : is computed as the ratio of remaining value of the bridge structure to the initial value of the structure. Since it : is expressed as a perc...

Effect of voids in grouted post-tensioned concrete bridge construction : inspection and repair manual for external tendons in segmental, post-tensioned bridges.

DOT National Transportation Integrated Search

2009-11-01

Segmental, post-tensioned (PT) bridges are major structures that carry significant traffic. These bridges are designed and constructed because they are economical for spanning long distances. In Texas, there are several signature PT bridges. In the l...

50. INTERIOR OF BRIDGE SUSPENSION STRUCTURE ABOVE BRIDGE NOS. 10 ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

50. INTERIOR OF BRIDGE SUSPENSION STRUCTURE ABOVE BRIDGE NOS. 10 AND 9 SHOWING CABLE COUNTERWEIGHT SYSTEM AND SCREW-TYPE VERTICAL ADJUSTMENT MACHINERY (LIFTING SCREWS). LOOKING NORTH. - Greenville Yard, Transfer Bridge System, Port of New York/New Jersey, Upper New York Bay, Jersey City, Hudson County, NJ

A novel abutment construction technique for rapid bridge construction : controlled low strength Materials (CLSM) with full-height concrete panels.

DOT National Transportation Integrated Search

2012-01-01

One of the major obstacles facing rapid bridge construction for typical span type bridges is the time required to construct bridge abutments and foundations. This can be remedied by using the controlled low strength materials (CLSM) bridge abutment. ...

Precast concrete elements for accelerated bridge construction : laboratory testing, field testing, evaluation of a precast concrete bridge, Madison County bridge.

DOT National Transportation Integrated Search

2009-01-01

The importance of rapid construction technologies has been recognized by the Federal Highway Administration (FHWA) and the Iowa : DOT Office of Bridges and Structures. Recognizing this a two-lane single-span precast box girder bridge was constructed ...

26. VIEW FROM EAST IN BRIDGE TENDER'S HOUSE, LEVERS FOR ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

26. VIEW FROM EAST IN BRIDGE TENDER'S HOUSE, LEVERS FOR GASOLINE ENGINE OPERATION FOR BRIDGE AND THEIR CONNECTIONS TO CONTROL RODS ON DOWNSTREAM SIDE OF SWING-SPAN; new bridge located in background - Tipers Bridge, Spanning Great Wicomico River at State Route 200, Kilmarnock, Lancaster County, VA

Reliability Modeling of Double Beam Bridge Crane

NASA Astrophysics Data System (ADS)

Han, Zhu; Tong, Yifei; Luan, Jiahui; Xiangdong, Li

2018-05-01

This paper briefly described the structure of double beam bridge crane and the basic parameters of double beam bridge crane are defined. According to the structure and system division of double beam bridge crane, the reliability architecture of double beam bridge crane system is proposed, and the reliability mathematical model is constructed.

A technical report on structural evaluation of the Meade County reinforced concrete bridge : research [summary].

DOT National Transportation Integrated Search

2009-01-01

Meade County Bridge is a two-lane highway reinforced concrete bridge with two girders each with 20 continuous spans. The bridge was built in 1965. It has been reported that in early years of the bridge service period, a considerable amount of cracks ...

A Bridge for Our Children: Tribal/University Partnerships to Prepare Indigenous Teachers

ERIC Educational Resources Information Center

White, Carolyne J.; Bedonie, Clara; de Groat, Jennie; Lockard, Louise; Honani, Samantha

2007-01-01

This article is about bridge building: building cultural bridges of authentic collaboration between the university and the Navajo and Hopi nations; building curricular bridges between the White, European culture and the cultural worlds these nations seek to preserve; and building bridges between languages, the language of the…

2. VIEW SHOWING SOUTH ELEVATION OF BRIDGE, LOOKING NORTH. THE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. VIEW SHOWING SOUTH ELEVATION OF BRIDGE, LOOKING NORTH. THE ROCK ISLAND LINE RAILROAD BRIDGE CAN BE SEEN IN THE BACKGROUND TO THE NORTH, WITH THE BURLINGTON STREET BRIDGE IN THE DISTANCE Ryan - Benton Street Bridge, Spanning Iowa River at Benton Street, Iowa City, Johnson County, IA

Bridge deck fogging system : evaluation of field implementation of a fogging system used during bridge deck construction.

DOT National Transportation Integrated Search

2008-01-01

The objective of this research was to implement and evaluate a fogging system used to provide initial cure for a concrete bridge deck construction project. To accomplish this, Bridges 5500 and 5701 along NM26 were selected. Bridge 5500 was placed usi...

Geotextile reinforced bridge approach embankment : Lake River Bridge : Malin Highway , Klamath County, Oregon : construction report.

DOT National Transportation Integrated Search

1993-03-01

The transition from the roadway to the deck of a rigidly supported bridge is of concern to engineers and the travelling public. It is a common occurrence to feel a discontinuity between the roadway and bridge structure. Bridge engineers have tried to...

A Hierarchical Analysis of Bridge Decision Makers; the Role of New Technology Adoption in the Timber Bridge Market: Special Project Fiscal Year 1992

DOT National Transportation Integrated Search

1995-08-01

Bridge design engineers and local highway officials make bridge replacement decsions across the U.S. The Analytical Hierarchical Process was used to characterize the bridge material selection decisions of these individuals. State Departments of Trans...

Autonomous measurements of bridge pier and abutment scour using motion-sensing radio transmitters : technical transfer summary.

DOT National Transportation Integrated Search

2010-01-01

Scour around the foundations (piers and abutments) of a bridge due to river flow is often referred to as bridge scour. Bridge scour is a problem of national scope that has dramatic impacts on economics and safety of the traveling public. Bridge...

Evaluation of Effects of Fire on the I-465 Mainline Bridges : Volume II

DOT National Transportation Integrated Search

2012-06-01

Currently, when a bridge has been involved in a fire loading, DOT and inspectors are called to determine if the bridge is passable to : traffic. Inspectors must close the bridge for an indefinite period of time to take material samples from the bridg...

16. LOG AND PLANK BRIDGE ON ACCESS ROAD NEAR BRIDGE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

16. LOG AND PLANK BRIDGE ON ACCESS ROAD NEAR BRIDGE SITE; SAME STRUCTURE AS SHOWN IN PHOTO #12. ZION NP NEGATIVE NO. 967 ZIO. - Zion-Mount Carmel Highway, Virgin River Bridge, Spanning North Fork of Virgin River on Zion-Mount Carmel Highway, Springdale, Washington County, UT

49 CFR 237.71 - Determination of bridge load capacities.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Determination of bridge load capacities. 237.71... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION BRIDGE SAFETY STANDARDS Capacity of Bridges § 237.71 Determination of bridge load capacities. (a) Each track owner shall determine the load capacity of each of its...

49 CFR 236.312 - Movable bridge, interlocking of signal appliances with bridge devices.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Movable bridge, interlocking of signal appliances with bridge devices. 236.312 Section 236.312 Transportation Other Regulations Relating to... SYSTEMS, DEVICES, AND APPLIANCES Interlocking Standards § 236.312 Movable bridge, interlocking of signal...

33 CFR 115.30 - Sufficiency of State authority for bridges.

Code of Federal Regulations, 2010 CFR

2010-07-01

... for bridges. 115.30 Section 115.30 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES BRIDGE LOCATIONS AND CLEARANCES; ADMINISTRATIVE PROCEDURES § 115.30 Sufficiency of State authority for bridges. An opinion of the attorney general of the State as to the sufficiency of State...

78 FR 40265 - Notice of Final Federal Agency Action on Proposed Bridge Replacement in Massachusetts

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-03

... on Proposed Bridge Replacement in Massachusetts AGENCY: Federal Highway Administration (FHWA), DOT... actions relate to the proposed Mitchell River Bridge (Bridge Street over the Mitchell River) Replacement...). A claim seeking judicial review of the Federal agency actions on the bridge project will be barred...

46 CFR 113.35-17 - Vessels with navigating bridge control.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Vessels with navigating bridge control. 113.35-17... bridge control. Each vessel with navigating bridge throttle control must have a positive mechanical stop on each telegraph transmitter that prevents movement to the “Navigating Bridge Control” position...

78 FR 34424 - National Bridge Inspection Standards Review Process; Notice and Request for Comment

Federal Register 2010, 2011, 2012, 2013, 2014

2013-06-07

...] National Bridge Inspection Standards Review Process; Notice and Request for Comment AGENCY: Federal Highway Administration (FHWA), DOT. ACTION: Notice; request for comment. SUMMARY: The National Bridge Inspection... structures defined as highway bridges on public roads. The FHWA annually reviews each State's bridge...

Development of Inspection Robots for Bridge Cables

PubMed Central

Kim, Se-Hoon; Lee, Jong-Jae

2013-01-01

This paper presents the bridge cable inspection robot developed in Korea. Two types of the cable inspection robots were developed for cable-suspension bridges and cable-stayed bridge. The design of the robot system and performance of the NDT techniques associated with the cable inspection robot are discussed. A review on recent advances in emerging robot-based inspection technologies for bridge cables and current bridge cable inspection methods is also presented. PMID:24459453

Evaluation of a Concrete Continuous Beam Bridge Using Load Test

NASA Astrophysics Data System (ADS)

Zhang, Xiedong; Li, Hong; Li, Xiaofan; Xiang, Musheng; Shen, Chengwu

2007-03-01

Load test is an efficient way to evaluate highway bridges. This paper presents static and dynamic load tests on a prestressed concrete continuous beam bridge. We obtained the influence line and the vibration property of the bridge from FEM analysis. The stress, deformation and the vibration characteristics of the bridge were measured. We found that the measured data are consistent with those from the theoretical calculation, indicating good condition of the bridge.

Characterization of stormwater runoff from bridges in North Carolina and the effects of bridge deck runoff on receiving streams

USGS Publications Warehouse

Wagner, Chad R.; Fitzgerald, Sharon A.; Sherrell, Roy D.; Harned, Douglas A.; Staub, Erik L.; Pointer, Brian H.; Wehmeyer, Loren L.

2011-01-01

In 2008, the North Carolina General Assembly passed House Bill 2436 that required the North Carolina Department of Transportation (NCDOT) to study the water-quality effects of bridges on receiving streams. In response, the NCDOT and the U.S. Geological Survey (USGS) collaborated on a study to provide information necessary to address the requirements of the Bill. To better understand the effects of stormwater runoff from bridges on receiving streams, the following tasks were performed: (1) characterize stormwater runoff quality and quantity from a representative selection of bridges in North Carolina; (2) measure stream water quality upstream from selected bridges to compare bridge deck stormwater concentrations and loads to stream constituent concentrations and loads; and (3) determine if the chemistry of bed sediments upstream and downstream from selected bridges differs substantially based on presence or absence of a best management practice for bridge runoff.

Free energy of solvated salt bridges: a simulation and experimental study.

PubMed

White, Andrew D; Keefe, Andrew J; Ella-Menye, Jean-Rene; Nowinski, Ann K; Shao, Qing; Pfaendtner, Jim; Jiang, Shaoyi

2013-06-20

Charged amino acids are the most common on surfaces of proteins and understanding the interactions between these charged amino acids, salt bridging, is crucial for understanding protein-protein interactions. Previous simulations have been limited to implicit solvent or fixed binding geometry due to the sampling required for converged free energies. Using well-tempered metadynamics, we have calculated salt bridge free energy surfaces in water and confirmed the results with NMR experiments. The simulations give binding free energies, quantitative ranking of salt bridging strength, and insights into the hydration of the salt bridges. The arginine-aspartate salt bridge was found to be the weakest and arginine-glutamate the strongest, showing that arginine can discriminate between aspartate and glutamate, whereas the salt bridges with lysine are indistinguishable in their free energy. The salt bridging hydration is found to be complementary to salt bridge orientation with arginine having specific orientations.

Bridging: Locating Critical Connectors in a Network

PubMed Central

Valente, Thomas W.; Fujimoto, Kayo

2010-01-01

This paper proposes several measures for bridging in networks derived from Granovetter's (1973) insight that links which reduce distances in a network are important structural bridges. Bridging is calculated by systematically deleting links and calculating the resultant changes in network cohesion (measured as the inverse average path length). The average change for each node's links provides an individual level measure of bridging. We also present a normalized version which controls for network size and a network level bridging index. Bridging properties are demonstrated on hypothetical networks, empirical networks, and a set of 100 randomly generated networks to show how the bridging measure correlates with existing network measures such as degree, personal network density, constraint, closeness centrality, betweenness centrality, and vitality. Bridging and the accompanying methodology provide a family of new network measures useful for studying network structure, network dynamics, and network effects on substantive behavioral phenomenon. PMID:20582157

Fuzzy Based Decision Support System for Condition Assessment and Rating of Bridges

NASA Astrophysics Data System (ADS)

Srinivas, Voggu; Sasmal, Saptarshi; Karusala, Ramanjaneyulu

2016-09-01

In this work, a knowledge based decision support system has been developed to efficiently handle the issues such as distress diagnosis, assessment of damages and condition rating of existing bridges towards developing an exclusive and robust Bridge Management System (BMS) for sustainable bridges. The Knowledge Based Expert System (KBES) diagnoses the distresses and finds the cause of distress in the bridge by processing the data which are heuristic and combined with site inspection results, laboratory test results etc. The coupling of symbolic and numeric type of data has been successfully implemented in the expert system to strengthen its decision making process. Finally, the condition rating of the bridge is carried out using the assessment results obtained from the KBES and the information received from the bridge inspector. A systematic procedure has been developed using fuzzy mathematics for condition rating of bridges by combining the fuzzy weighted average and resolution identity technique. The proposed methodologies and the decision support system will facilitate in developing a robust and exclusive BMS for a network of bridges across the country and allow the bridge engineers and decision makers to carry out maintenance of bridges in a rational and systematic way.

The structure of salt bridges between Arg(+) and Glu(-) in peptides investigated with 2D-IR spectroscopy: Evidence for two distinct hydrogen-bond geometries.

PubMed

Huerta-Viga, Adriana; Amirjalayer, Saeed; Domingos, Sérgio R; Meuzelaar, Heleen; Rupenyan, Alisa; Woutersen, Sander

2015-06-07

Salt bridges play an important role in protein folding and in supramolecular chemistry, but they are difficult to detect and characterize in solution. Here, we investigate salt bridges between glutamate (Glu(-)) and arginine (Arg(+)) using two-dimensional infrared (2D-IR) spectroscopy. The 2D-IR spectrum of a salt-bridged dimer shows cross peaks between the vibrational modes of Glu(-) and Arg(+), which provide a sensitive structural probe of Glu(-)⋯Arg(+) salt bridges. We use this probe to investigate a β-turn locked by a salt bridge, an α-helical peptide whose structure is stabilized by salt bridges, and a coiled coil that is stabilized by intra- and intermolecular salt bridges. We detect a bidentate salt bridge in the β-turn, a monodentate one in the α-helical peptide, and both salt-bridge geometries in the coiled coil. To our knowledge, this is the first time 2D-IR has been used to probe tertiary side chain interactions in peptides, and our results show that 2D-IR spectroscopy is a powerful method for investigating salt bridges in solution.

Natural canopy bridges effectively mitigate tropical forest fragmentation for arboreal mammals.

PubMed

Gregory, Tremaine; Carrasco-Rueda, Farah; Alonso, Alfonso; Kolowski, Joseph; Deichmann, Jessica L

2017-06-20

Linear infrastructure development and resulting habitat fragmentation are expanding in Neotropical forests, and arboreal mammals may be disproportionately impacted by these linear habitat clearings. Maintaining canopy connectivity through preservation of connecting branches (i.e. natural canopy bridges) may help mitigate that impact. Using camera traps, we evaluated crossing rates of a pipeline right-of-way in a control area with no bridges and in a test area where 13 bridges were left by the pipeline construction company. Monitoring all canopy crossing points for a year (7,102 canopy camera nights), we confirmed bridge use by 25 mammal species from 12 families. With bridge use beginning immediately after exposure and increasing over time, use rates were over two orders of magnitude higher than on the ground. We also found a positive relationship between a bridge's use rate and the number of species that used it, suggesting well-used bridges benefit multiple species. Data suggest bridge use may be related to a combination of bridge branch connectivity, multiple connections, connectivity to adjacent forest, and foliage cover. Given the high use rate and minimal cost, we recommend all linear infrastructure projects in forests with arboreal mammal populations include canopy bridges.

The structure of salt bridges between Arg+ and Glu- in peptides investigated with 2D-IR spectroscopy: Evidence for two distinct hydrogen-bond geometries

NASA Astrophysics Data System (ADS)

Huerta-Viga, Adriana; Amirjalayer, Saeed; Domingos, Sérgio R.; Meuzelaar, Heleen; Rupenyan, Alisa; Woutersen, Sander

2015-06-01

Salt bridges play an important role in protein folding and in supramolecular chemistry, but they are difficult to detect and characterize in solution. Here, we investigate salt bridges between glutamate (Glu-) and arginine (Arg+) using two-dimensional infrared (2D-IR) spectroscopy. The 2D-IR spectrum of a salt-bridged dimer shows cross peaks between the vibrational modes of Glu- and Arg+, which provide a sensitive structural probe of Glu-⋯Arg+ salt bridges. We use this probe to investigate a β-turn locked by a salt bridge, an α-helical peptide whose structure is stabilized by salt bridges, and a coiled coil that is stabilized by intra- and intermolecular salt bridges. We detect a bidentate salt bridge in the β-turn, a monodentate one in the α-helical peptide, and both salt-bridge geometries in the coiled coil. To our knowledge, this is the first time 2D-IR has been used to probe tertiary side chain interactions in peptides, and our results show that 2D-IR spectroscopy is a powerful method for investigating salt bridges in solution.

Dynamic Interaction of Long Suspension Bridges with Running Trains

NASA Astrophysics Data System (ADS)

XIA, H.; XU, Y. L.; CHAN, T. H. T.

2000-10-01

This paper presents an investigation of dynamic interaction of long suspension bridges with running trains. A three-dimensional finite element model is used to represent a long suspension bridge. Each 4-axle vehicle in a train is modelled by a 27-degrees-of-freedom dynamic system. The dynamic interaction between the bridge and train is realized through the contact forces between the wheels and track. By applying a mode superposition technique to the bridge only and taking the measured track irregularities as known quantities, the number of degrees of freedom (d.o.f.) the bridge-train system is significantly reduced and the coupled equations of motion are efficiently solved. The proposed formulation and the associated computer program are then applied to a real long suspension bridge carrying a railway within the bridge deck. The dynamic response of the bridge-train system and the derail and offload factors related to the running safety of the train are computed. The results show that the formulation presented in this paper can well predict dynamic behaviors of both bridge and train with reasonable computation efforts. Dynamic interaction between the long suspension bridge and train is not significant.

The effect of modified bridge exercise on balance ability of stroke patients.

PubMed

Song, Gui-Bin; Heo, Ju-Young

2015-12-01

[Purpose] The purpose of this study was to verify the effects of a modified bridging exercise on stroke patients with improvement in weight bearing on the affected side in standing and static balancing ability. [Subjects] Thirty patients who had a stroke were randomly allocated into a supine bridge exercise group (SBG, n=10), a supine bridge exercise on a TOGU balance pad group (SBTG, n=10), and a unilateral bridge exercise group (UBG, n=10). [Methods] The SBG patients underwent supine bridge exercise, the SBTG patients underwent supine bridge exercise with a TOGU balance pad, and the UBG patients underwent unilateral bridge exercise. All groups received 20 minutes of training per day, five times per week, for four weeks. [Results] All groups showed significant changes in weight bearing in a standing position after the intervention. The SBTG and UBG groups showed significant changes in balance ability. [Conclusion] According to the results of this study, bridge exercise was effective in improving weight bearing in a standing position and improving balance on stroke patients. The bridge exercise with a TOGU balance pad and the unilateral bridge exercise were especially more effective in anterior, posterior length in limit of stability following on standing.

Prevalence of myocardial bridging detected with 64-slice multidetector coronary computed tomography angiography in asymptomatic adults.

PubMed

Atar, Eli; Kornowski, Ran; Fuchs, Shmuell; Naftali, Noa; Belenky, Alexander; Bachar, Gil N

2007-10-01

Myocardial bridging is a congenital condition in which a segment of an epicardial artery has an intramural course within the myocardium. The aim of the present study was to evaluate the prevalence of myocardial bridging and the ability of 64-slice coronary computed tomography angiography to identify myocardial bridging in asymptomatic adults. One hundred sixty-nine consecutive asymptomatic subjects underwent 64-row multidetector computed tomography (MDCT) of the coronary arteries. Two experienced CT radiologists identified myocardial bridging >1 mm in thickness, by consensus. We examined the frequency of myocardial bridging and evaluated the length, thickness, and coronary wall lesions. Myocardial bridges were found in 28 (17%) of 165 subjects. Twenty-one subjects (75%) had 1 bridge and 7 subjects (25%) had 2, for a total of 35 myocardial bridges. Twenty-one bridges (60%) were located in the left anterior descending, 8.5% in the diagonal branch, and 2.8% in the circumflex arteries. The segment beneath the myocardial bridge was always free of coronary wall plaques, but the arterial segment proximal to it had significant coronary wall plaques in 24 cases (68.6%). We found that the incidence of myocardial bridging in asymptomatic adults is 7%, which is in agreement with some pathologic studies in the literature. Our study shows that MDCT of the coronary arteries is a reliable and noninvasive technique, which can accurately locate the site of myocardial bridging, and measure its thickness, course, and length.

Anatomy and prevalence of atlas vertebrae bridges in a Kenyan population: An osteological study.

PubMed

Karau, Paul Bundi; Ogengo, Julius A; Hassanali, Jameela; Odula, Paul

2010-09-01

Atlas bridges are bony outgrowths over the third segment of the vertebral artery. They may exist as incipient, incomplete, or complete bridges, converting the groove into a deep sulcus, incomplete, or complete foramen respectively. These bridges and their associated foramina display bilateral and sex differences in their prevalence and type. Occurrence of these bridges may predispose to vertebrobasilar insufficiency and Barre-Lieou syndrome. The coexistence of lateral and posterior bridges as well as side predilection is not clear in either sex. Their relative occurrence may also point to some evolutionary patterns. We studied the prevalence, side predilection, coexistence, and anatomical features of atlas bridges using 102 dry atlases (49 males and 53 females) obtained from the osteology department of the National Museums of Kenya. Complete posterior bridges occurred in 14.7% and 13.7% on the right and left sides, respectively. A lateral bridge was found in 3.9% of cases on the right side only. There was positive correlation in the coexistence of the bridges. A retrotransverse foramen was found in 13% of cases. This study has found that posterior and lateral atlas bridges occur in association especially on the right side. Complete bridges were more prevalent in females and were more often present on the right side. This pattern seems to mirror the sexual predilection of vertebral artery compression syndromes. Gender roles may have an influence on the occurrence of these bridges and therefore the syndromes as well.

Removal of failed crown and bridge

PubMed Central

Rahul, G R.; Poduval, Soorya T.; Shetty, Karunakar

2012-01-01

Crown and bridge have life span of many years but they fail for a number of reasons. Over the years, many devices have been designed to remove crowns and bridges from abutment teeth. While the removal of temporary crowns and bridges is usually very straightforward, the removal of a definitive cast crown with unknown cement is more challenging. Removal is often by destructive means. There are a number of circumstances, however, in which conservative disassembly would aid the practitioner in completing restorative/endodontic procedures. There are different mechanisms available to remove a failed crown or bridge. But there is no information published about the classification of available systems for crown and bridge removal. So it is logical to classify these systems into different groups which can help a clinician in choosing a particular type of system depending upon the clinical situation. The aim of this article is to provide a classification for various crown and bridge removal systems; describe how a number of systems work; and when and why they might be used. A PubMed search of English literature was conducted up to January 2010 using the terms: Crown and bridge removal, Crown and bridge disassembly, Crown and bridge failure. Additionally, the bibliographies of 3 previous reviews, their cross references as well as articles published in various journals like International Endodontic Journal, Journal of Endodontics and were manually searched. Key words:Crown and bridge removal, Crown and bridge disassembly, Crown and bridge failure. PMID:24558549

Building Better Bridges into STEM: A Synthesis of 25 Years of Literature on STEM Summer Bridge Programs.

PubMed

Ashley, Michael; Cooper, Katelyn M; Cala, Jacqueline M; Brownell, Sara E

2017-01-01

Summer bridge programs are designed to help transition students into the college learning environment. Increasingly, bridge programs are being developed in science, technology, engineering, and mathematics (STEM) disciplines because of the rigorous content and lower student persistence in college STEM compared with other disciplines. However, to our knowledge, a comprehensive review of STEM summer bridge programs does not exist. To provide a resource for bridge program developers, we conducted a systematic review of the literature on STEM summer bridge programs. We identified 46 published reports on 30 unique STEM bridge programs that have been published over the past 25 years. In this review, we report the goals of each bridge program and whether the program was successful in meeting these goals. We identify 14 distinct bridge program goals that can be organized into three categories: academic success goals, psychosocial goals, and department-level goals. Building on the findings of published bridge reports, we present a set of recommendations for STEM bridge programs in hopes of developing better bridges into college. © 2017 M. Ashley, K. M. Cooper, et al. CBE—Life Sciences Education © 2017 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

Introducing the refined gravity hypothesis of extreme sexual size dimorphism

PubMed Central

2010-01-01

Background Explanations for the evolution of female-biased, extreme Sexual Size Dimorphism (SSD), which has puzzled researchers since Darwin, are still controversial. Here we propose an extension of the Gravity Hypothesis (i.e., the GH, which postulates a climbing advantage for small males) that in conjunction with the fecundity hypothesis appears to have the most general power to explain the evolution of SSD in spiders so far. In this "Bridging GH" we propose that bridging locomotion (i.e., walking upside-down under own-made silk bridges) may be behind the evolution of extreme SSD. A biomechanical model shows that there is a physical constraint for large spiders to bridge. This should lead to a trade-off between other traits and dispersal in which bridging would favor smaller sizes and other selective forces (e.g. fecundity selection in females) would favor larger sizes. If bridging allows faster dispersal, small males would have a selective advantage by enjoying more mating opportunities. We predicted that both large males and females would show a lower propensity to bridge, and that SSD would be negatively correlated with sexual dimorphism in bridging propensity. To test these hypotheses we experimentally induced bridging in males and females of 13 species of spiders belonging to the two clades in which bridging locomotion has evolved independently and in which most of the cases of extreme SSD in spiders are found. Results We found that 1) as the degree of SSD increased and females became larger, females tended to bridge less relative to males, and that 2) smaller males and females show a higher propensity to bridge. Conclusions Physical constraints make bridging inefficient for large spiders. Thus, in species where bridging is a very common mode of locomotion, small males, by being more efficient at bridging, will be competitively superior and enjoy more mating opportunities. This "Bridging GH" helps to solve the controversial question of what keeps males small and also contributes to explain the wide range of SSD in spiders, as those spider species in which extreme SSD has not evolved but still live in tall vegetation, do not use bridging locomotion to disperse. PMID:20682029

Effect of modified bridge exercise on trunk muscle activity in healthy adults: a cross sectional study.

PubMed

Yoon, Jeong-Oh; Kang, Min-Hyeok; Kim, Jun-Seok; Oh, Jae-Seop

This is a cross-sectional study. University research laboratory. Fifteen healthy adults (mean age: 27.47 years) volunteered for this study. The individuals performed standard bridge exercise and modified bridge exercises with right leg-lift (single-leg-lift bridge exercise, single-leg-lift bridge exercise on an unstable surface, and single-leg-lift hip abduction bridge exercise). During the bridge exercises, electromyography of the rectus abdominis, internal oblique, erector spinae, and multifidus muscles was recorded using a wireless surface electromyography system. Two-way repeated-measures analysis of variance (exercise by side) with post hoc pairwise comparisons using Bonferroni correction was used to compare the electromyography data collected from each muscle. Bilateral internal oblique muscle activities showed significantly greater during single-leg-lift bridge exercise (95% confidence interval: right internal oblique=-8.99 to -1.08, left internal oblique=-6.84 to -0.10), single-leg-lift bridge exercise on an unstable surface (95% confidence interval: right internal oblique=-7.32 to -1.78, left internal oblique=-5.34 to -0.99), and single-leg-lift hip abduction bridge exercise (95% confidence interval: right internal oblique=-17.13 to -0.89, left internal oblique=-8.56 to -0.60) compared with standard bridge exercise. Bilateral rectus abdominis showed greater electromyography activity during single-leg-lift bridge exercise on an unstable surface (95% confidence interval: right rectus abdominis=-9.33 to -1.13, left rectus abdominis=-4.80 to -0.64) and single-leg-lift hip abduction bridge exercise (95% confidence interval: right rectus abdominis=-14.12 to -1.84, left rectus abdominis=-6.68 to -0.16) compared with standard bridge exercise. In addition, the right rectus abdominis muscle activity was greater during single-leg-lift hip abduction bridge exercise compared with single-leg-lift bridge exercise on an unstable surface (95% confidence interval=-7.51 to -0.89). For erector spinae, muscle activity was greater in right side compared with left side during all exercises (95% confidence interval: standard bridge exercise=0.19-4.53, single-leg-lift bridge exercise=0.24-10.49, single-leg-lift bridge exercise on an unstable surface=0.74-8.55, single-leg-lift hip abduction bridge exercise=0.47-11.43). There was no significant interaction and main effect for multifidus. Adding hip abduction and unstable conditions to bridge exercises may be useful strategy to facilitate the co-activation of trunk muscles. Copyright © 2017 Associação Brasileira de Pesquisa e Pós-Graduação em Fisioterapia. Publicado por Elsevier Editora Ltda. All rights reserved.

Investigation of Aerodynamic Interference between Twin Deck Bridges

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sitek, M. A.; Bojanowski, C.; Lottes, S. A.

2016-05-01

Construction of a twin bridge can be a cost effective and minimally disruptive way to increase capacity when an existing bridge is not near the end of its service life. With ever growing vehicular traffic, when demand approaches the capacity of many existing roads and bridges. Remodeling a structure with an insufficient number of lanes can be a good solution in case of smaller and less busy bridges. Closing down or reducing traffic on crossings of greater importance for the construction period, however, can result in major delays and revenue loss for commerce and transportation as well as increasing themore » traffic load on alternate route bridges. Multiple-deck bridges may be the answer to this issue. A parallel deck can be built next to the existing one, without reducing the flow. Additionally, a new bridge can be designed as a twin or multi-deck structure. Several such structures have been built throughout the United States, among them: - The New NY Bridge Project - the Tappan Zee Hudson River Crossing, - SR-182 Columbia River Bridge, - The Thaddeus Kosciusko Bridge (I-87), - The Allegheny River Bridge, Pennsylvania, which carries I76, - Fred Hartman Bridge, TX, see Figure 1.2. With a growing number of double deck bridges, additional, more detailed, studies on the interaction of such bridge pairs in windy conditions appears appropriate. Aerodynamic interference effects should be examined to assure the aerodynamic stability of both bridges. There are many studies on aerodynamic response of single deck bridges, but the literature on double-deck structures is not extensive. The experimental results from wind tunnels are still limited in number, as a parametric study is required, they can be very time consuming. Literature review shows that some investigation of the effects of gap-width and angle of wind incidence has been done. Most of the CFD computational studies that have been done were limited to 2D simulations. Therefore, it is desirable to investigate twin decks of various cross-sections, gap-to-width ratios, wind speed and direction using three-dimensional CFD simulations. After verification with wind tunnel test results, this type of analysis could become a powerful tool for future designs as well as for monitoring of existing bridges.« less

Increased of the capacity integral bridge with reinforced concrete beams for single span

NASA Astrophysics Data System (ADS)

Setiati, N. Retno

2017-11-01

Sinapeul Bridge that was built in 2012 in Sumedang is a bridge type using a full integral system. The prototype of integral bridge with reinforced concrete girder and single span 20 meters until this year had decreased capacity. The bridge was conducted monitoring of strain that occurs in the abutment in 2014. Monitoring results show that based on the data recorded, the maximum strain occurs at the abutment on the location of the integration of the girder of 10.59 x 10-6 tensile stress of 0.25 MPa (smaller than 150 x 10-6) with 3 MPa tensile stress as limit the occurrence of cracks in concrete. Sinapeul bridge abutment with integral system is still in the intact condition. Deflection of the bridge at the time of load test is 1.31 mm. But this time the bridge has decreased exceeded permission deflection (deflection occurred by 40 mm). Besides that, the slab also suffered destruction. One cause of the destruction of the bridge slab is the load factor. It is necessary for required effort to increase the capacity of the integral bridge with retrofitting. Retrofitting method also aims to restore the capacity of the bridge structure due to deterioration. Retrofitting can be done by shortening of the span or using Fibre Reinforced Polymer (FRC). Based on the results obtained by analysis of that method of retrofitting with Fibre Reinforced Polymer (FRC) is more simple and effective. Retrofitting with FRP can increase the capacity of the shear and bending moment becomes 41% of the existing bridge. Retrofitting with FRP method does not change the integral system on the bridge Sinapeul become conventional bridges.

Salt-bridge networks within globular and disordered proteins: characterizing trends for designable interactions.

PubMed

Basu, Sankar; Mukharjee, Debasish

2017-07-01

There has been considerable debate about the contribution of salt bridges to the stabilization of protein folds, in spite of their participation in crucial protein functions. Salt bridges appear to contribute to the activity-stability trade-off within proteins by bringing high-entropy charged amino acids into close contacts during the course of their functions. The current study analyzes the modes of association of salt bridges (in terms of networks) within globular proteins and at protein-protein interfaces. While the most common and trivial type of salt bridge is the isolated salt bridge, bifurcated salt bridge appears to be a distinct salt-bridge motif having a special topology and geometry. Bifurcated salt bridges are found ubiquitously in proteins and interprotein complexes. Interesting and attractive examples presenting different modes of interaction are highlighted. Bifurcated salt bridges appear to function as molecular clips that are used to stitch together large surface contours at interacting protein interfaces. The present work also emphasizes the key role of salt-bridge-mediated interactions in the partial folding of proteins containing long stretches of disordered regions. Salt-bridge-mediated interactions seem to be pivotal to the promotion of "disorder-to-order" transitions in small disordered protein fragments and their stabilization upon binding. The results obtained in this work should help to guide efforts to elucidate the modus operandi of these partially disordered proteins, and to conceptualize how these proteins manage to maintain the required amount of disorder even in their bound forms. This work could also potentially facilitate explorations of geometrically specific designable salt bridges through the characterization of composite salt-bridge networks. Graphical abstract ᅟ.

Simulations of floodflows on the White River in the vicinity of U.S. Highway 79 near Clarendon, Arkansas

USGS Publications Warehouse

Funkhouser, Jaysson E.; Barks, C. Shane

2003-01-01

A two-dimensional finite-element surface-water model was used to study the effects of the proposed modification to the U.S. Highway 79 corridor on flooding on the White River near Clarendon, Arkansas. The effects of floodflows were simulated for the following scenarios: existing, natural, and four proposed bridging alternatives. All of the scenarios were modeled with floods having the 5- and 100-year recurrence intervals (115,100 and 216,000 cubic feet per second). The simulated existing conditions included a 3,200-foot White River bridge located on the east side of the study area near Clarendon, Arkansas; a 3,700-foot First Old River bridge located 0.5 mile west of the White River bridge opening; and a 1,430-foot Roc Roe Bayou bridge located 1.6 mile west of the First Old River bridge. The simulated hypothetical natural conditions involved removing the U.S. Highway 79 and the Union Pacific Railroad embankments along the entire length of the flood plain. The primary purpose of model simulations for natural conditions was to calculate backwater data for the existing and proposed conditions. The four simulated hypothetical proposed alternatives involved a 1.8-mile White River bridge located on the east side of the study area near Clarendon, Arkansas, either a 1,400-foot relief bridge (Alternative 1) or a 1,545 relief bridge (Alternatives 2-4) located 0.25 mile west of the White River bridge opening, and three different Roc Roe Bayou bridge openings ranging from 1,540-3,475 feet in length located 0.9 mile west of the relief bridge (Alternatives 1-4). Simulation of the 5-year floodflow for the existing bridge openings indicates that about 57 percent (65,600 cubic feet per second) of flow was conveyed by the White River bridge, about 26 percent (29,900 cubic feet per second) by the First Old River bridge, and about 17 percent (19,600 cubic feet per second) by the Roc Roe Bayou bridge. Maximum depth-averaged point velocities for the White River, First Old River, and Roc Roe Bayou bridges were 3.6, 1.6, and 3.3 feet per second, respectively. For the 100-year floodflow, the simulation indicates that about 56 percent (123,100 cubic feet per second) of flow was conveyed by the White River bridge, about 26 percent (56,200 cubic feet per second) by the First Old River bridge, and about 19 percent (41,000 cubic feet per second) by the Roc Roe Bayou bridge. The maximum depth-averaged point velocities for the White River, First Old River, and Roc Roe Bayou bridges were 4.2, 2.2, and 4.1 feet per second, respectively. Simulation of the 5-year floodflow for the proposed U.S. Highway 79 alignment alternatives indicates that 76-78 percent (87,100-89,900 cubic feet per second) of the flow was conveyed by the proposed White River bridge, 6-7 percent (7,000-7,500 cubic feet per second) by the proposed relief bridge, and 13-16 percent (14,600-18,600 cubic feet per second) by the proposed Roc Roe Bayou bridge. For the 100-year floodflow, simulations predicted that 70-72 percent (151,200-155,600 cubic feet per second) of the flow was conveyed by the proposed White River bridge, 9-10 percent (19,800-20,700 cubic feet per second) by the proposed relief bridge, and 14-20 percent (30,700-43,000 cubic feet per second) by the proposed Roc Roe Bayou bridge.

Acquisition and Analysis of Dynamic Responses of a Historic Pedestrian Bridge using Video Image Processing

NASA Astrophysics Data System (ADS)

O'Byrne, Michael; Ghosh, Bidisha; Schoefs, Franck; O'Donnell, Deirdre; Wright, Robert; Pakrashi, Vikram

2015-07-01

Video based tracking is capable of analysing bridge vibrations that are characterised by large amplitudes and low frequencies. This paper presents the use of video images and associated image processing techniques to obtain the dynamic response of a pedestrian suspension bridge in Cork, Ireland. This historic structure is one of the four suspension bridges in Ireland and is notable for its dynamic nature. A video camera is mounted on the river-bank and the dynamic responses of the bridge have been measured from the video images. The dynamic response is assessed without the need of a reflector on the bridge and in the presence of various forms of luminous complexities in the video image scenes. Vertical deformations of the bridge were measured in this regard. The video image tracking for the measurement of dynamic responses of the bridge were based on correlating patches in time-lagged scenes in video images and utilisinga zero mean normalisedcross correlation (ZNCC) metric. The bridge was excited by designed pedestrian movement and by individual cyclists traversing the bridge. The time series data of dynamic displacement responses of the bridge were analysedto obtain the frequency domain response. Frequencies obtained from video analysis were checked against accelerometer data from the bridge obtained while carrying out the same set of experiments used for video image based recognition.

Acquisition and Analysis of Dynamic Responses of a Historic Pedestrian Bridge using Video Image Processing

NASA Astrophysics Data System (ADS)

O'Byrne, Michael; Ghosh, Bidisha; Schoefs, Franck; O'Donnell, Deirdre; Wright, Robert; Pakrashi, Vikram

2015-07-01

Video based tracking is capable of analysing bridge vibrations that are characterised by large amplitudes and low frequencies. This paper presents the use of video images and associated image processing techniques to obtain the dynamic response of a pedestrian suspension bridge in Cork, Ireland. This historic structure is one of the four suspension bridges in Ireland and is notable for its dynamic nature. A video camera is mounted on the river-bank and the dynamic responses of the bridge have been measured from the video images. The dynamic response is assessed without the need of a reflector on the bridge and in the presence of various forms of luminous complexities in the video image scenes. Vertical deformations of the bridge were measured in this regard. The video image tracking for the measurement of dynamic responses of the bridge were based on correlating patches in time-lagged scenes in video images and utilisinga zero mean normalised cross correlation (ZNCC) metric. The bridge was excited by designed pedestrian movement and by individual cyclists traversing the bridge. The time series data of dynamic displacement responses of the bridge were analysedto obtain the frequency domain response. Frequencies obtained from video analysis were checked against accelerometer data from the bridge obtained while carrying out the same set of experiments used for video image based recognition.

25 CFR 170.505 - How must bridge inspections be coordinated?

Code of Federal Regulations, 2011 CFR

2011-04-01

... 25 Indians 1 2011-04-01 2011-04-01 false How must bridge inspections be coordinated? 170.505 Section 170.505 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR LAND AND WATER INDIAN... Bridge Inspection § 170.505 How must bridge inspections be coordinated? This section applies to bridge...

23 CFR 661.21 - When is a bridge eligible for rehabilitation?

Code of Federal Regulations, 2011 CFR

2011-04-01

... 23 Highways 1 2011-04-01 2011-04-01 false When is a bridge eligible for rehabilitation? 661.21... TRAFFIC OPERATIONS INDIAN RESERVATION ROAD BRIDGE PROGRAM § 661.21 When is a bridge eligible for rehabilitation? To be eligible for rehabilitation, the bridge must be considered structurally deficient or...

49 CFR 237.73 - Protection of bridges from over-weight and over-dimension loads.

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 4 2011-10-01 2011-10-01 false Protection of bridges from over-weight and over... (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION BRIDGE SAFETY STANDARDS Capacity of Bridges § 237.73 Protection of bridges from over-weight and over-dimension loads. (a) Each track owner...

23 CFR 661.47 - Can bridge maintenance be performed with IRRBP funds?

Code of Federal Regulations, 2011 CFR

2011-04-01

... 23 Highways 1 2011-04-01 2011-04-01 false Can bridge maintenance be performed with IRRBP funds... ENGINEERING AND TRAFFIC OPERATIONS INDIAN RESERVATION ROAD BRIDGE PROGRAM § 661.47 Can bridge maintenance be performed with IRRBP funds? No. Bridge maintenance repairs, e.g., guard rail repair, deck repairs, repair of...

23 CFR 661.19 - When is a bridge eligible for replacement?

Code of Federal Regulations, 2011 CFR

2011-04-01

... 23 Highways 1 2011-04-01 2011-04-01 false When is a bridge eligible for replacement? 661.19... TRAFFIC OPERATIONS INDIAN RESERVATION ROAD BRIDGE PROGRAM § 661.19 When is a bridge eligible for replacement? To be eligible for replacement, the bridge must be considered structurally deficient or...

23 CFR 661.47 - Can bridge maintenance be performed with IRRBP funds?

Code of Federal Regulations, 2010 CFR

2010-04-01

... ENGINEERING AND TRAFFIC OPERATIONS INDIAN RESERVATION ROAD BRIDGE PROGRAM § 661.47 Can bridge maintenance be performed with IRRBP funds? No. Bridge maintenance repairs, e.g., guard rail repair, deck repairs, repair of... 23 Highways 1 2010-04-01 2010-04-01 false Can bridge maintenance be performed with IRRBP funds...

75 FR 227 - Drawbridge Operation Regulations; Harlem River, New York, NY

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-05

... operation regulations by expanding the bridge opening periods and also removes redundant language and... vessels that fit under the existing bridges in the closed position and do not require bridge openings... traffic that can fit under the other bridges without a bridge opening can not transit under the Spuyten...

33 CFR 117.139 - White River.

Code of Federal Regulations, 2011 CFR

2011-07-01

... Southwestern railroad bridge, mile 98.9 at Clarendon, the US70 highway bridge, mile 121.7 at DeValls Bluff, the Chicago, Rock Island and Pacific Railroad bridge, mile 122.0 at DeValls Bluff, the Missouri Pacific railroad bridge, mile 196.3 at Augusta, and the Missouri Pacific railroad bridge, mile 254.8 at Newport...

33 CFR 117.205 - Connecticut River.

Code of Federal Regulations, 2013 CFR

2013-07-01

... owners of the AMTRAK Old Saybrook-Old Lyme Bridge, mile 3.4 the Route 82 Bridge, mile 16.8, and the CONRAIL Middletown-Portland Bridge, mile 32.0, shall provide, and keep in good legible condition... Bridge, mile 3.4, and the CONRAIL Middletown-Portland Bridge, mile 32.0, shall be opened as soon as...

33 CFR 117.205 - Connecticut River.

Code of Federal Regulations, 2012 CFR

2012-07-01

... owners of the AMTRAK Old Saybrook-Old Lyme Bridge, mile 3.4 the Route 82 Bridge, mile 16.8, and the CONRAIL Middletown-Portland Bridge, mile 32.0, shall provide, and keep in good legible condition... Bridge, mile 3.4, and the CONRAIL Middletown-Portland Bridge, mile 32.0, shall be opened as soon as...

33 CFR 117.139 - White River.

Code of Federal Regulations, 2012 CFR

2012-07-01

... Southwestern railroad bridge, mile 98.9 at Clarendon, the US70 highway bridge, mile 121.7 at DeValls Bluff, the Chicago, Rock Island and Pacific Railroad bridge, mile 122.0 at DeValls Bluff, the Missouri Pacific railroad bridge, mile 196.3 at Augusta, and the Missouri Pacific railroad bridge, mile 254.8 at Newport...

33 CFR 117.465 - Lafourche Bayou.

Code of Federal Regulations, 2012 CFR

2012-07-01

..., mile 23.9, at Golden Meadow (2) Galliano Pontoon Bridge, mile 27.8, at Galliano (3) SR 308 (South Lafourche (Tarpon)) Bridge, mile 30.6, at Galliano (4) Cote Blanche Pontoon Bridge, mile 33.9, at Cutoff (5) Cutoff Vertical Lift Bridge, mile 36.3, at Cutoff (6) SR 310 (Larose Pontoon) Bridge, mile 39.1, at...

33 CFR 117.205 - Connecticut River.

Code of Federal Regulations, 2010 CFR

2010-07-01

... owners of the AMTRAK Old Saybrook-Old Lyme Bridge, mile 3.4 the Route 82 Bridge, mile 16.8, and the CONRAIL Middletown-Portland Bridge, mile 32.0, shall provide, and keep in good legible condition... Bridge, mile 3.4, and the CONRAIL Middletown-Portland Bridge, mile 32.0, shall be opened as soon as...

33 CFR 117.139 - White River.

Code of Federal Regulations, 2013 CFR

2013-07-01

... Southwestern railroad bridge, mile 98.9 at Clarendon, the US70 highway bridge, mile 121.7 at DeValls Bluff, the Chicago, Rock Island and Pacific Railroad bridge, mile 122.0 at DeValls Bluff, the Missouri Pacific railroad bridge, mile 196.3 at Augusta, and the Missouri Pacific railroad bridge, mile 254.8 at Newport...

33 CFR 117.139 - White River.

Code of Federal Regulations, 2014 CFR

2014-07-01

... Southwestern railroad bridge, mile 98.9 at Clarendon, the US70 highway bridge, mile 121.7 at DeValls Bluff, the Chicago, Rock Island and Pacific Railroad bridge, mile 122.0 at DeValls Bluff, the Missouri Pacific railroad bridge, mile 196.3 at Augusta, and the Missouri Pacific railroad bridge, mile 254.8 at Newport...

33 CFR 117.205 - Connecticut River.

Code of Federal Regulations, 2011 CFR

2011-07-01

... owners of the AMTRAK Old Saybrook-Old Lyme Bridge, mile 3.4 the Route 82 Bridge, mile 16.8, and the CONRAIL Middletown-Portland Bridge, mile 32.0, shall provide, and keep in good legible condition... Bridge, mile 3.4, and the CONRAIL Middletown-Portland Bridge, mile 32.0, shall be opened as soon as...

33 CFR 117.205 - Connecticut River.

Code of Federal Regulations, 2014 CFR

2014-07-01

... owners of the AMTRAK Old Saybrook-Old Lyme Bridge, mile 3.4 the Route 82 Bridge, mile 16.8, and the CONRAIL Middletown-Portland Bridge, mile 32.0, shall provide, and keep in good legible condition... Bridge, mile 3.4, and the CONRAIL Middletown-Portland Bridge, mile 32.0, shall be opened as soon as...

14. RAILROAD BRIDGE MISSISSIPPI, MONROE CO., ABERDEEN Reach by foot ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

14. RAILROAD BRIDGE MISSISSIPPI, MONROE CO., ABERDEEN Reach by foot from E end of Vine St. St. Louis and San Francisco RR bridge. Bridge built 1887, replaced, 1969. Credit: Evans Memorial Library, Aberdeen, Ms. No date. Sarcone Photography, Columbus, Ms. Sep 1978. - Bridges of the Upper Tombigbee River Valley, Columbus, Lowndes County, MS

Long continuous bridge deck evaluation : John Day River Bridge, Clatsop County, Bridge No. 1827B : final report.

DOT National Transportation Integrated Search

1995-06-01

The John Day River Bridge, near Astoria, Oregon was built with a continuous deck length of 1,105 ft. (340 m). The rationale for designing the John Day River Bridge with an unusually long continuous deck is in part based on the site's very mild climat...

Construction of a Virginia short-span bridge with the Strongwell 36-inch double-web I-beam.

DOT National Transportation Integrated Search

2005-01-01

The Route 601 Bridge in Sugar Grove, VA, spans 39 ft over Dickey Creek. The bridge is the first to use the Strongwell 36-in-deep fiber-reinforced polymer (FRP) double-web beam (DWB) in a vehicular bridge superstructure. Construction of the new bridge...

76 FR 18779 - National Register of Historic Places; Notification of Pending Nominations and Related Actions

Federal Register 2010, 2011, 2012, 2013, 2014

2011-04-05

... Bluewater Creek Bridge, (Reinforced Concrete Bridges in Montana, 1900-1958 MPS) Milepost 8 on Bluewater Cr. Rd., Fromberg, 11000223 Dawson County Bad Route Creek Bridge, (Reinforced Concrete Bridges in Montana..., (Reinforced Concrete Bridges in Montana, 1900- 1958 MPS) Milepost 5 on Recreation Rd., Wolf Creek, 11000225...

76 FR 32313 - Safety Zone; Chelsea St. Bridge Demolition, Chelsea River, Chelsea, MA

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-06

...-AA00 Safety Zone; Chelsea St. Bridge Demolition, Chelsea River, Chelsea, MA AGENCY: Coast Guard, DHS... Sector Boston Captain of the Port (COTP) Zone for the demolition of the Chelsea St. Bridge. This safety... Chelsea St. Bridge during the operations surrounding the bridge's demolition and removal. Discussion of...

Economic benefits of additional rail bridge capacity: a case study on the benefits of replacing the Merchants Bridge main spans at Saint Louis.

DOT National Transportation Integrated Search

2015-11-01

The Merchants Memorial Mississippi Rail Bridge and MacArthur Bridge over the Mississippi River make up the most heavily : used Mississippi River rail crossing in the country. A large contributor to the popularity of the Merchants Bridge is its : acce...

Standard practice for washing and cleaning concrete bridge decks and substructure bridge seats including bridge bearings and expansion joints to prevent structural deterioration.

DOT National Transportation Integrated Search

2013-12-01

This study is a supplement to a previous study of bridge washing practices that focused on steel : superstructures. This study examined the perceived costs and benefits of routine washing of both : steel and concrete bridges, with emphasis on substru...

76 FR 63858 - Drawbridge Operation Regulation; Trent River, New Bern, NC

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-14

... River Bridge Runs. This deviation allows the bridge to remain in the closed position to ensure safe..., Docket Operations, telephone 202-366-9826. SUPPLEMENTARY INFORMATION: The Neuse River Bridge Run... River, mile 0.0, at New Bern, NC. The route of the three Neuse River Bridge Run races cross the bridge...

Aerial view of the entire bridge crossing the Tennessee River ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Aerial view of the entire bridge crossing the Tennessee River looking up river. The swing bridge, when open, permits river navigational traffic to ply the river. Construction of a replacement bridge, to be located 93.27 feet down river, has now started. - Bridgeport Swing Span Bridge, Spanning Tennessee River, Bridgeport, Jackson County, AL

23 CFR 661.19 - When is a bridge eligible for replacement?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 23 Highways 1 2010-04-01 2010-04-01 false When is a bridge eligible for replacement? 661.19... TRAFFIC OPERATIONS INDIAN RESERVATION ROAD BRIDGE PROGRAM § 661.19 When is a bridge eligible for replacement? To be eligible for replacement, the bridge must be considered structurally deficient or...

77 FR 43557 - Safety Zone; Gilmerton Bridge Center Span Float-in, Elizabeth River; Norfolk, Portsmouth, and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-25

...-AA00 Safety Zone; Gilmerton Bridge Center Span Float-in, Elizabeth River; Norfolk, Portsmouth, and... during the Gilmerton Bridge Center Span Float- in and bridge construction of span placement. This action... Construction, INC will facilitate removal of the existing bascule spans from the Gilmerton Bridge, transport of...

77 FR 35900 - Safety Zone; Gilmerton Bridge Center Span Float-in, Elizabeth River; Norfolk, Portsmouth, and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-15

...-AA00 Safety Zone; Gilmerton Bridge Center Span Float-in, Elizabeth River; Norfolk, Portsmouth, and... navigable waters during the Gilmerton Bridge Center Span Float- in and bridge construction of span placement... the existing bascule spans from the Gilmerton Bridge, transport the new center span from the Eastern...

46 CFR 32.16-1 - Navigation bridge visibility-T/ALL.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 46 Shipping 1 2010-10-01 2010-10-01 false Navigation bridge visibility-T/ALL. 32.16-1 Section 32..., AND HULL REQUIREMENTS Navigation Bridge Visibility § 32.16-1 Navigation bridge visibility-T/ALL. Each..., must meet the following requirements: (a) The field of vision from the navigation bridge, whether the...

49 CFR 237.73 - Protection of bridges from over-weight and over-dimension loads.

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 4 2010-10-01 2010-10-01 false Protection of bridges from over-weight and over... (Continued) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION BRIDGE SAFETY STANDARDS Capacity of Bridges § 237.73 Protection of bridges from over-weight and over-dimension loads. (a) Each track owner...

77 FR 44544 - Safety Zone; Gilmerton Bridge Center Span Float-In, Elizabeth River; Norfolk, Portsmouth, and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-30

...-AA00 Safety Zone; Gilmerton Bridge Center Span Float-In, Elizabeth River; Norfolk, Portsmouth, and... withdrawing its proposed rule concerning the Gilmerton Bridge Center Span Float-in and bridge construction of... ``Safety Zone; Gilmerton Bridge Center Span Float-in, Elizabeth River; Norfolk, Portsmouth, and Chesapeake...

Guide for In-Place Treatment of Covered and Timber Bridges

Treesearch

Stan Lebow; Grant Kirker; Robert White; Terry Amburgey; H. Michael Barnes; Michael Sanders; Jeff Morrell

2012-01-01

Historic covered bridges and current timber bridges can be vulnerable to damage from biodeterioration or fire. This guide describes procedures for selecting and applying in-place treatments to prevent or arrest these forms of degradation. Vulnerable areas for biodeterioration in covered bridges include members contacting abutments, members near the ends of bridges...

23 CFR 661.21 - When is a bridge eligible for rehabilitation?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 23 Highways 1 2010-04-01 2010-04-01 false When is a bridge eligible for rehabilitation? 661.21... TRAFFIC OPERATIONS INDIAN RESERVATION ROAD BRIDGE PROGRAM § 661.21 When is a bridge eligible for rehabilitation? To be eligible for rehabilitation, the bridge must be considered structurally deficient or...

13. UNIDENTIFIED CABLESTAYED SUSPENSION BRIDGE WITH TIMBER RAILING OF TWELVE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

13. UNIDENTIFIED CABLE-STAYED SUSPENSION BRIDGE WITH TIMBER RAILING OF TWELVE PANELS, SHOWING CABLE PATTERN SIMILAR TO E.E. RUNYON'S SUSPENSION BRIDGE PATENTS. THE BLUFF DALE SUSPENSION BRIDGE'S CABLES MAY HAVE ORIGINALLY FOLLOWED THIS PATTERN. ELEVATION VIEW. - Bluff Dale Suspension Bridge, Spanning Paluxy River at County Route 149, Bluff Dale, Erath County, TX

Development, verification, and application of a simplified method to estimate total-streambed scour at bridge sites in Illinois

USGS Publications Warehouse

Holmes, Robert R.; Dunn, Chad J.

1996-01-01

A simplified method to estimate total-streambed scour was developed for application to bridges in the State of Illinois. Scour envelope curves, developed as empirical relations between calculated total scour and bridge-site chracteristics for 213 State highway bridges in Illinois, are used in the method to estimate the 500-year flood scour. These 213 bridges, geographically distributed throughout Illinois, had been previously evaluated for streambed scour with the application of conventional hydraulic and scour-analysis methods recommended by the Federal Highway Administration. The bridge characteristics necessary for application of the simplified bridge scour-analysis method can be obtained from an office review of bridge plans, examination of topographic maps, and reconnaissance-level site inspection. The estimates computed with the simplified method generally resulted in a larger value of 500-year flood total-streambed scour than with the more detailed conventional method. The simplified method was successfully verified with a separate data set of 106 State highway bridges, which are geographically distributed throughout Illinois, and 15 county highway bridges.

Effects of Irregular Bridge Columns and Feasibility of Seismic Regularity

NASA Astrophysics Data System (ADS)

Thomas, Abey E.

2018-05-01

Bridges with unequal column height is one of the main irregularities in bridge design particularly while negotiating steep valleys, making the bridges vulnerable to seismic action. The desirable behaviour of bridge columns towards seismic loading is that, they should perform in a regular fashion, i.e. the capacity of each column should be utilized evenly. But, this type of behaviour is often missing when the column heights are unequal along the length of the bridge, allowing short columns to bear the maximum lateral load. In the present study, the effects of unequal column height on the global seismic performance of bridges are studied using pushover analysis. Codes such as CalTrans (Engineering service center, earthquake engineering branch, 2013) and EC-8 (EN 1998-2: design of structures for earthquake resistance. Part 2: bridges, European Committee for Standardization, Brussels, 2005) suggests seismic regularity criterion for achieving regular seismic performance level at all the bridge columns. The feasibility of adopting these seismic regularity criterions along with those mentioned in literatures will be assessed for bridges designed as per the Indian Standards in the present study.

Computational Fluid Dynamic Analysis of Hydrodynamic forces on inundated bridge decks

NASA Astrophysics Data System (ADS)

Afzal, Bushra; Guo, Junke; Kerenyi, Kornel

2010-11-01

The hydraulic forces experienced by an inundated bridge deck have great importance in the design of bridges. Flood flows or hurricane add significant hydrodynamic loading on bridges, possibly resulting in failure of the bridge superstructures. The objective of the study is to establish validated computational practice to address research needs of the transportation community via computational fluid dynamic simulations. The reduced scale experiments conducted at Turner-Fairbank Highway Research Center establish the foundations of validated computational practices to address the research needs of the transportation community. Three bridge deck prototypes were used: a typical six-girder highway bridge deck, a three-girder deck, and a streamlined deck designed to better withstand the hydraulic forces. Results of the study showed that the streamlined deck significantly reduces drag, lift, and moment coefficient in comparison to the other bridge deck types. The CFD results matched the experimental data in terms of the relationship between inundation ratio and force measured at the bridge. The results of the present research will provide a tool for designing new bridges and retrofitting old ones.

Influence of microclimate on the sustainability and reliability of weathering steel bridge

NASA Astrophysics Data System (ADS)

Kubzova, M.; Krivy, V.; Kreislova, K.

2018-04-01

Reliability and sustainability of bridge structures designed from weathering steel are influenced by the development of a sufficiently protective layer of corrosion products on its surface. The development of this protective layer is affected by several parameters such as air pollution around the bridge structure, the microclimate under the bridge, the location of surface within the bridge structure and the time of wetness. Design of structural details also significantly influences the development of the protective corrosion layer. The article deals with the results of the experimental tests carried out on the road bridge located in the city of Ostrava in the Czech Republic. The development of the protective corrosion layer on the surface of the bridge is significantly influenced by the intensive traffic under the bridge construction and the design solution of the bridge itself. Attention is focused mainly on the influence of chloride deposition on the protective function of the corrosion layer. Corrosion samples were placed on the bridge to evaluate the influence of the above-mentioned parameters. The deposition rate of chlorides spreading from the road to surfaces of the steel structure is also measured.

Adhesion of bubbles and drops to solid surfaces, and anisotropic surface tensions studied by capillary meniscus dynamometry.

PubMed

Danov, Krassimir D; Stanimirova, Rumyana D; Kralchevsky, Peter A; Marinova, Krastanka G; Stoyanov, Simeon D; Blijdenstein, Theodorus B J; Cox, Andrew R; Pelan, Eddie G

2016-07-01

Here, we review the principle and applications of two recently developed methods: the capillary meniscus dynamometry (CMD) for measuring the surface tension of bubbles/drops, and the capillary bridge dynamometry (CBD) for quantifying the bubble/drop adhesion to solid surfaces. Both methods are based on a new data analysis protocol, which allows one to decouple the two components of non-isotropic surface tension. For an axisymmetric non-fluid interface (e.g. bubble or drop covered by a protein adsorption layer with shear elasticity), the CMD determines the two different components of the anisotropic surface tension, σs and σφ, which are acting along the "meridians" and "parallels", and vary throughout the interface. The method uses data for the instantaneous bubble (drop) profile and capillary pressure, but the procedure for data processing is essentially different from that of the conventional drop shape analysis (DSA) method. In the case of bubble or drop pressed against a substrate, which forms a capillary bridge, the CBD method allows one to determine also the capillary-bridge force for both isotropic (fluid) and anisotropic (solidified) adsorption layers. The experiments on bubble (drop) detachment from the substrate show the existence of a maximal pulling force, Fmax, that can be resisted by an adherent fluid particle. Fmax can be used to quantify the strength of adhesion of bubbles and drops to solid surfaces. Its value is determined by a competition of attractive transversal tension and repulsive disjoining pressure forces. The greatest Fmax values have been measured for bubbles adherent to glass substrates in pea-protein solutions. The bubble/wall adhesion is lower in solutions containing the protein HFBII hydrophobin, which could be explained with the effect of sandwiched protein aggregates. The applicability of the CBD method to emulsion systems is illustrated by experiments with soybean-oil drops adherent to hydrophilic and hydrophobic substrates in egg yolk solutions. The results reveal how the interfacial rigidity, as well as the bubble/wall and drop/wall adhesion forces, can be quantified and controlled in relation to optimizing the properties of foams and emulsions. Copyright © 2015 Elsevier B.V. All rights reserved.

Elkmont Vehicle Bridge, Construction PeelAway Great Smoky Mountains National ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Elkmont Vehicle Bridge, Construction Peel-Away - Great Smoky Mountains National Park Roads & Bridges, Elkmont Vehicle Bridge, Spanning Little River at Elkmont Campground, Gatlinburg, Sevier County, TN

Bridge permeameter

DOEpatents

Graf, Darin C.; Warpinski, Norman R.

1996-01-01

A system for single-phase, steady-state permeability measurements of porous rock utilizes a fluid bridge arrangement analogous to a Wheatstone bridge. The arms of the bridge contain the sample and calibrated flow resistors.

Tungsten bridge for the low energy ignition of explosive and energetic materials

DOEpatents

Benson, David A.; Bickes, Jr., Robert W.; Blewer, Robert S.

1990-01-01

A tungsten bridge device for the low energy ignition of explosive and energetic materials is disclosed. The device is fabricated on a silicon-on-sapphire substrate which has an insulating bridge element defined therein using standard integrated circuit fabrication techniques. Then, a thin layer of tungsten is selectively deposited on the silicon bridge layer using chemical vapor deposition techniques. Finally, conductive lands are deposited on each end of the tungsten bridge layer to form the device. It has been found that this device exhibits substantially shorter ignition times than standard metal bridges and foil igniting devices. In addition, substantially less energy is required to cause ignition of the tungsten bridge device of the present invention than is required for common metal bridges and foil devices used for the same purpose.

Bridge resource program.

DOT National Transportation Integrated Search

2013-09-01

The mission of Rutgers Universitys Center for Advanced Infrastructure and Transportation (CAIT) Bridge Resource Program (BRP) is to provide bridge engineering support to the New Jersey Department of Transportation (NJDOT)s Bridge Engineering an...

NCDOT : bridge policy

DOT National Transportation Integrated Search

1994-11-01

NCDOTs Bridge Policy establishes controlling design elements for new and reconstructed bridges on the state road system. It includes information to address sidewalks and bicycle facilities on bridges, including minimum handrail heights and sidewal...

Morphological aspects of myocardial bridges.

PubMed

Lujinović, Almira; Kulenović, Amela; Kapur, Eldan; Gojak, Refet

2013-11-01

Although some myocardial bridges can be asymptomatic, their presence often causes coronary disease either through direct compression of the "tunnel" segment or through stimulation and accelerated development of atherosclerosis in the segment proximally to the myocardial bridge. The studied material contained 30 human hearts received from the Department of Anatomy. The hearts were preserved 3 to 5 days in 10% formalin solution. Thereafter, the fatty tissue was removed and arterial blood vessels prepared by careful dissection with special reference to the presence of the myocardial bridges. Length and thickness of the bridges were measured by the precise electronic caliper. The angle between the myocardial bridge fibre axis and other axis of the crossed blood vessel was measured by a goniometer. The presence of the bridges was confirmed in 53.33% of the researched material, most frequently (43.33%) above the anterior interventricular branch. The mean length of the bridges was 14.64 ± 9.03 mm and the mean thickness was 1.23 ± 1.32 mm. Myocardial bridge fibres pass over the descending blood vessel at the angle of 10-90 degrees. The results obtained on a limited sample suggest that the muscular index of myocardial bridge is the highest for bridges located on RIA, but that the difference is not significant in relation to bridges located on other branches. The results obtained suggest that bridges located on other branches, not only those on RIA, could have a great contractive power and, consequently, a great compressive force, which would be exerted on the wall of a crossed blood vessel.

Repeated multibeam echosounder hydrographic surveys of 15 selected bridge crossings along the Missouri River from Niobrara to Rulo, Nebraska, during the flood of 2011

USGS Publications Warehouse

Dietsch, Benjamin J.; Densmore, Brenda K.; Strauch, Kellan R.

2014-01-01

In 2011, unprecedented flooding in the Missouri River prompted transportation agencies to increase the frequency of monitoring riverbed elevations near bridges that cross the Missouri River. Hydrographic surveys were completed in cooperation with the Nebraska Department of Roads, using a multibeam echosounder at 15 highway bridges spanning the Missouri River from Niobrara to Rulo, Nebraska during and after the extreme 2011 flood. Evidence of bed elevation change near bridge piers was documented. The greatest amount of bed elevation change during the 2011 flood documented for this study occurred at the Burt County Missouri River Bridge at Decatur, Nebraska, where scour of about 45 feet, from before flooding, occurred between a bridge abutment and pier. Of the remaining sites, highway bridges where bed elevation change near piers appeared to have exceeded 10 feet include the Abraham Lincoln Memorial Bridge at Blair, Nebr., Bellevue Bridge at Bellevue, Nebr., and Nebraska City Bridge at Nebraska City, Nebr. Hydrographic surveys at 14 of the 15 sites were completed in mid-July and again in early October or late-November 2011. Near three of the bridges, the bed elevation of locations surveyed in July increased by more than 10 feet, on average, by late October or early November 2011. Bed elevations increased between 1 and 10 feet, on average, near six bridges. Near the remaining four bridges, bed elevations decreased between 1 and 4 feet, on average, from July to late October or early November.

Salt bridge as a gatekeeper against partial unfolding.

PubMed

Hinzman, Mark W; Essex, Morgan E; Park, Chiwook

2016-05-01

Salt bridges are frequently observed in protein structures. Because the energetic contribution of salt bridges is strongly dependent on the environmental context, salt bridges are believed to contribute to the structural specificity rather than the stability. To test the role of salt bridges in enhancing structural specificity, we investigated the contribution of a salt bridge to the energetics of native-state partial unfolding in a cysteine-free version of Escherichia coli ribonuclease H (RNase H*). Thermolysin cleaves a protruding loop of RNase H(*) through transient partial unfolding under native conditions. Lys86 and Asp108 in RNase H(*) form a partially buried salt bridge that tethers the protruding loop. Investigation of the global stability of K86Q/D108N RNase H(*) showed that the salt bridge does not significantly contribute to the global stability. However, K86Q/D108N RNase H(*) is greatly more susceptible to proteolysis by thermolysin than wild-type RNase H(*) is. The free energy for partial unfolding determined by native-state proteolysis indicates that the salt bridge significantly increases the energy for partial unfolding by destabilizing the partially unfolded form. Double mutant cycles with single and double mutations of the salt bridge suggest that the partially unfolded form is destabilized due to a significant decrease in the interaction energy between Lys86 and Asp108 upon partial unfolding. This study demonstrates that, even in the case that a salt bridge does not contribute to the global stability, the salt bridge may function as a gatekeeper against partial unfolding that disturbs the optimal geometry of the salt bridge. © 2016 The Protein Society.

Roy D. Bridges Bridge

NASA Image and Video Library

2003-08-06

From left, incoming KSC Director James W. Kennedy looks on as departing KSC Director Roy D. Bridges Jr. shakes hands with the 45th Space Wing Commander Brig. Gen. J. Gregory Pavlovich. The occasion is the unveiling of the new sign on the NASA Causeway naming the bridge for Bridges who is leaving KSC to become the director of NASA's Langley Research Center, Hampton, Va. The bridge spans the Banana River on the NASA Causeway and connects Kennedy Space Center and Cape Canaveral Air Force Station.

Geometry control of long-span continuous girder concrete bridge during construction through finite element model updating

NASA Astrophysics Data System (ADS)

Wu, Jie; Yan, Quan-sheng; Li, Jian; Hu, Min-yi

2016-04-01

In bridge construction, geometry control is critical to ensure that the final constructed bridge has the consistent shape as design. A common method is by predicting the deflections of the bridge during each construction phase through the associated finite element models. Therefore, the cambers of the bridge during different construction phases can be determined beforehand. These finite element models are mostly based on the design drawings and nominal material properties. However, the accuracy of these bridge models can be large due to significant uncertainties of the actual properties of the materials used in construction. Therefore, the predicted cambers may not be accurate to ensure agreement of bridge geometry with design, especially for long-span bridges. In this paper, an improved geometry control method is described, which incorporates finite element (FE) model updating during the construction process based on measured bridge deflections. A method based on the Kriging model and Latin hypercube sampling is proposed to perform the FE model updating due to its simplicity and efficiency. The proposed method has been applied to a long-span continuous girder concrete bridge during its construction. Results show that the method is effective in reducing construction error and ensuring the accuracy of the geometry of the final constructed bridge.

A cloud-based information repository for bridge monitoring applications

NASA Astrophysics Data System (ADS)

Jeong, Seongwoon; Zhang, Yilan; Hou, Rui; Lynch, Jerome P.; Sohn, Hoon; Law, Kincho H.

2016-04-01

This paper describes an information repository to support bridge monitoring applications on a cloud computing platform. Bridge monitoring, with instrumentation of sensors in particular, collects significant amount of data. In addition to sensor data, a wide variety of information such as bridge geometry, analysis model and sensor description need to be stored. Data management plays an important role to facilitate data utilization and data sharing. While bridge information modeling (BrIM) technologies and standards have been proposed and they provide a means to enable integration and facilitate interoperability, current BrIM standards support mostly the information about bridge geometry. In this study, we extend the BrIM schema to include analysis models and sensor information. Specifically, using the OpenBrIM standards as the base, we draw on CSI Bridge, a commercial software widely used for bridge analysis and design, and SensorML, a standard schema for sensor definition, to define the data entities necessary for bridge monitoring applications. NoSQL database systems are employed for data repository. Cloud service infrastructure is deployed to enhance scalability, flexibility and accessibility of the data management system. The data model and systems are tested using the bridge model and the sensor data collected at the Telegraph Road Bridge, Monroe, Michigan.

Free energy landscape of a minimalist salt bridge model.

PubMed

Li, Xubin; Lv, Chao; Corbett, Karen M; Zheng, Lianqing; Wu, Dongsheng; Yang, Wei

2016-01-01

Salt bridges are essential to protein stability and dynamics. Despite the importance, there has been scarce of detailed discussion on how salt bridge partners interact with each other in distinct solvent exposed environments. In this study, employing a recent generalized orthogonal space tempering (gOST) method, we enabled efficient molecular dynamics simulation of repetitive breaking and reforming of salt bridge structures within a minimalist salt-bridge model, the Asp-Arg dipeptide and thereby were able to map its detailed free energy landscape in aqueous solution. Free energy surface analysis shows that although individually-solvated states are more favorable, salt-bridge states still occupy a noticeable portion of the overall population. Notably, the competing forces, e.g. intercharge attractions that drive the formation of salt bridges and solvation forces that pull the charged groups away from each other, are energetically comparable. As the result, the salt bridge stability is highly tunable by local environments; for instance when local water molecules are perturbed to interact more strongly with each other, the population of the salt-bridge states is likely to increase. Our results reveal the critical role of local solvent structures in modulating salt-bridge partner interactions and imply the importance of water fluctuations on conformational dynamics that involves solvent accessible salt bridge formations. © 2015 The Protein Society.

1. Photocopied January 1973 from the Keystone Bridge Company Album, ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Photocopied January 1973 from the Keystone Bridge Company Album, 1874. THE KEYSTONE BRIDGE COMPANY: LUCY FURNACE. - Baltimore & Ohio Railroad, Parkersburg Bridge, Ohio River, Parkersburg, Wood County, WV

Chickamauga National Military Park Tour Roads, Gordon's Slough Bridge, At ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

Chickamauga National Military Park Tour Roads, Gordon's Slough Bridge, At the confluence of Alexander's Bridge Road and Gordon's Slough, southeast of Alexander's Bridge, Fort Oglethorpe, Catoosa County, GA

23 CFR 661.55 - How are BIA and Tribal owned IRR bridges inspected?

Code of Federal Regulations, 2011 CFR

2011-04-01

... 23 Highways 1 2011-04-01 2011-04-01 false How are BIA and Tribal owned IRR bridges inspected? 661... AND TRAFFIC OPERATIONS INDIAN RESERVATION ROAD BRIDGE PROGRAM § 661.55 How are BIA and Tribal owned IRR bridges inspected? BIA and Tribally owned IRR bridges are inspected in accordance with 25 CFR part...

33 CFR 118.95 - Lights on structures not part of a bridge or approach structure.

Code of Federal Regulations, 2011 CFR

2011-07-01

... a bridge or approach structure. 118.95 Section 118.95 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES BRIDGE LIGHTING AND OTHER SIGNALS § 118.95 Lights on structures not part of a bridge or approach structure. Lights on sheer booms, isolated piers, obstructions, and other...

23 CFR 661.17 - What are the criteria for bridge eligibility?

Code of Federal Regulations, 2011 CFR

2011-04-01

... 23 Highways 1 2011-04-01 2011-04-01 false What are the criteria for bridge eligibility? 661.17... TRAFFIC OPERATIONS INDIAN RESERVATION ROAD BRIDGE PROGRAM § 661.17 What are the criteria for bridge eligibility? (a) Bridge eligibility requires the following: (1) Have an opening of 20 feet or more; (2) Be...

30 CFR 57.16015 - Work or travel on overhead crane bridges.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Work or travel on overhead crane bridges. 57... MINES Materials Storage and Handling § 57.16015 Work or travel on overhead crane bridges. No person shall work from or travel on the bridge of an overhead crane unless the bridge is provided with...

30 CFR 56.16015 - Work or travel on overhead crane bridges.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 30 Mineral Resources 1 2011-07-01 2011-07-01 false Work or travel on overhead crane bridges. 56... Materials Storage and Handling § 56.16015 Work or travel on overhead crane bridges. No person shall work from or travel on the bridge of an overhead crane unless the bridge is provided with substantial...

15. OLD ROAD BRIDGE MISSISSIPPI, MONROE CO., ABERDEEN (EAST ABERDEEN) ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

15. OLD ROAD BRIDGE MISSISSIPPI, MONROE CO., ABERDEEN (EAST ABERDEEN) One mile E of Aberdeen, 1000 ft. N of (1978) U.S. 45 bridge. Oblique view of bridge, in early 1900s. Credit: Evans Memorial Library, Aberdeen, MS. No date. Sarcone Photography, Columbus, Ms. Sep 1978. - Bridges of the Upper Tombigbee River Valley, Columbus, Lowndes County, MS

13. RAILROAD BRIDGE MISSISSIPPI, MONROE CO., ABERDEEN 1.5 mi. NW ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

13. RAILROAD BRIDGE MISSISSIPPI, MONROE CO., ABERDEEN 1.5 mi. NW of Amory. St. Louis and San Francisco RR bridge. Steam locomotive and coal train cross bridge on 10 August 1921. Credit: Owned by Jack Donnell, Columbus, Ms., photographer. Copied by Sarcone Photography, Columbus, Ms. - Bridges of the Upper Tombigbee River Valley, Columbus, Lowndes County, MS

13. Looking north, from the southern approach to the bridge. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

13. Looking north, from the southern approach to the bridge. The bridge deck, which is concrete with several patch coats of asphalt (now chiefly gravel and some turf), demonstrates a sharp gradient from the abutment to the bridge center line. - Vigo County Bridge No. 139, Spanning Sugar Creek at Seventy-fourth Place, Terre Haute, Vigo County, IN

A Hierarchical Analysis of Bridge Decision Makers ... The Role of New Technology Adoption in the Timber Bridge Market: Special Project

Treesearch

Robert L. Smith; Robert J. Bush; Daniel L. Schmoldt

1995-01-01

Bridge design engineers and local highway officials make bridge replacement decisions across the United States. The Analytical Hierarchy Process was used to characterize the bridge material selection decision of these individuals. State Department of Transportation engineers, private consulting engineers, and local highway officials were personally interviewed in...

The Six Track Scherzer Rolling Lift Bridge…Two double track spans ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

The Six Track Scherzer Rolling Lift Bridge…Two double track spans closed. One double-track span open. Photocopy of plate xvi in Scherzer Rolling Lift Bridge Company, Scherzer Rolling Lift Bridges. - New York, New Haven & Hartford Railroad, Fort Point Channel Rolling Lift Bridge, Spanning Fort Point Channel, Boston, Suffolk County, MA

Advanced bridge safety initiative : live load testing and load rating of the Evans Brook Bridge (#5506) and the Hastings Bridge (#5507) in Batchelders Grant, Maine.

DOT National Transportation Integrated Search

2014-01-01

The Advanced Structures and Composites Center at the University of Maine (UMaine) performed live load testing : and rating factor analysis for two bridges (No. 5506 and No. 5507) in Batchelders Grant, Maine. The bridge load : rating performed by cons...

Field performance of timber bridges. 14, Dean, Hibbsville, and Decatur stress-laminated deck bridges

Treesearch

P. D. Hilbrich Lee; M. A. Ritter; S. Golston; K. Hinds

1984-01-01

The Dean, Hibbsville, and Decatur bridges were constructed in southern Iowa during 1994. Each bridge is a simple-span, stress-laminated deck superstructure, approximately 7.3 m (24 ft) long, constructed from eastern cottonwood lumber. The performance of each bridge was monitored for approximately 2 years, beginning shortly after installation. Monitoring involved...

76 FR 38011 - Safety Zone; Hylebos Bridge Restoration, Hylebos Waterway, Tacoma, WA

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-29

...-AA00 Safety Zone; Hylebos Bridge Restoration, Hylebos Waterway, Tacoma, WA AGENCY: Coast Guard, DHS... extending 50 yards to the north and south of the Hylebos Bridge, Tacoma, WA in both directions along the entire length of the Hylebos Bridge to ensure the safety of the boating public during the Hylebos Bridge...

23 CFR 661.55 - How are BIA and Tribal owned IRR bridges inspected?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 23 Highways 1 2010-04-01 2010-04-01 false How are BIA and Tribal owned IRR bridges inspected? 661... AND TRAFFIC OPERATIONS INDIAN RESERVATION ROAD BRIDGE PROGRAM § 661.55 How are BIA and Tribal owned IRR bridges inspected? BIA and Tribally owned IRR bridges are inspected in accordance with 25 CFR part...

33 CFR 118.95 - Lights on structures not part of a bridge or approach structure.

Code of Federal Regulations, 2010 CFR

2010-07-01

... a bridge or approach structure. 118.95 Section 118.95 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES BRIDGE LIGHTING AND OTHER SIGNALS § 118.95 Lights on structures not part of a bridge or approach structure. Lights on sheer booms, isolated piers, obstructions, and other...

30 CFR 57.16015 - Work or travel on overhead crane bridges.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Work or travel on overhead crane bridges. 57... MINES Materials Storage and Handling § 57.16015 Work or travel on overhead crane bridges. No person shall work from or travel on the bridge of an overhead crane unless the bridge is provided with...

30 CFR 56.16015 - Work or travel on overhead crane bridges.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Work or travel on overhead crane bridges. 56... Materials Storage and Handling § 56.16015 Work or travel on overhead crane bridges. No person shall work from or travel on the bridge of an overhead crane unless the bridge is provided with substantial...

77 FR 73541 - Safety Zone: Gilmerton Bridge Center Span Float-in, Elizabeth River; Norfolk, Portsmouth, and...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-11

...-AA00 Safety Zone: Gilmerton Bridge Center Span Float-in, Elizabeth River; Norfolk, Portsmouth, and... Gilmerton Bridge Center Span Float- in and bridge construction of span placement. This action is intended to... rulemaking (NPRM) proposing a safety zone in the Gilmerton Bridge Area (77 FR 43557) on September 5-9, 2012...

33 CFR 116.45 - Submission of bids, approval of award, guaranty of cost, and partial payments for bridges...

Code of Federal Regulations, 2010 CFR

2010-07-01

... award, guaranty of cost, and partial payments for bridges eligible for funding under the Truman-Hobbs... SECURITY BRIDGES ALTERATION OF UNREASONABLY OBSTRUCTIVE BRIDGES § 116.45 Submission of bids, approval of award, guaranty of cost, and partial payments for bridges eligible for funding under the Truman-Hobbs...

23 CFR 661.17 - What are the criteria for bridge eligibility?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 23 Highways 1 2010-04-01 2010-04-01 false What are the criteria for bridge eligibility? 661.17... TRAFFIC OPERATIONS INDIAN RESERVATION ROAD BRIDGE PROGRAM § 661.17 What are the criteria for bridge eligibility? (a) Bridge eligibility requires the following: (1) Have an opening of 20 feet or more; (2) Be...

12. UNIDENTIFIED CABLESTAYED SUSPENSION BRIDGE WITH TIMBER RAILING OF TWELVE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

12. UNIDENTIFIED CABLE-STAYED SUSPENSION BRIDGE WITH TIMBER RAILING OF TWELVE PANELS, SHOWING CABLE PATTERN SIMILAR TO E.E. RUNYON'S SUSPENSION BRIDGE PATENTS. THE BLUFF DALE SUSPENSION BRIDGE'S CABLES MAY HAVE ORIGINALLY FOLLOWED THIS PATTERN. 3/4 VIEW FROM ABOVE. - Bluff Dale Suspension Bridge, Spanning Paluxy River at County Route 149, Bluff Dale, Erath County, TX

7. Photocopy of photograph, date unknown. VIEW OF WEST HIGH ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

7. Photocopy of photograph, date unknown. VIEW OF WEST HIGH STREET BRIDGE OVER SOUTH BRANCH OF FRENCH CREEK, WITH PENN RAILROAD BRIDGE IN BACKGROUND. (Original in Union City Historical Museum.) 8'x10' enlargement from 4'x5' negative. - Bridge Street Bridge, Spanning Little French Creek at Bridge Street, Union City, Erie County, PA

OBLIQUE VIEW SHOING THE OR&L BRIDGE IN THE FOREGROUND. NOTE ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

OBLIQUE VIEW SHOING THE OR&L BRIDGE IN THE FOREGROUND. NOTE THE ARC-PLAN END STACHION AND THE RELATIONSHIP BETWEEN THE OR&L BRIDGE AND THE WAIKELE CANAL BRIDGE, WHICH CAN BE SEEN IN THE BACKGROUND. VIEW FACING WEST. - Waikele Canal Bridge and Highway Overpass, Farrington Highway and Waikele Stream, Waipahu, Honolulu County, HI

Review of aeromedical intra-aortic balloon pump retrieval in New South Wales.

PubMed

Burns, Brian; Reid, Cliff; Habig, Karel

2013-02-01

The intra-aortic balloon pump (IABP) was first introduced in 1968 to augment cardiac output in the haemodynamically unstable patient and serve as a bridge to treatment options such as coronary artery bypass grafting and cardiac transplantation. Transfer of IABP-dependent patients for upgrade of clinical care is increasingly common and safe. In Australia, percutaneous coronary intervention centres can be located outside cardiothoracic surgical centres. This study reviews IABP medical retrieval by a doctor/paramedic team after implementation of a standardized protocol. This was a retrospective case series review, using descriptive statistics. Greater Sydney Area Helicopter Emergency Service carried out 22 cases from 1 May 2007 to 31 December 2009. Median age was 62 years [interquartile range (IQR) 51-83], 67% were male. In all, 63% of patients were retrieved on inotropic support, 29% overall received invasive ventilation. Highest frequency indications were myocardial infarction, cardiogenic shock and bridge to coronary artery bypass grafts. There were complications during 18% of all retrievals and no adverse outcomes. Of the patients, 67% (14/21) were retrieved by road and 33% (7/21) by helicopter (longest distance 500 km). Median stabilization time by a retrieval team was 1 h 15 min (IQR 50 min to 3 h 30 min). Median mission time was 4 h 55 min (IQR 3 h 50 min to 8 h 54 min). Our system offers a safe method of IABP medical retrieval. The doctor and paramedic combination complements strengths in logistics and critical care. This serves as a guide to other systems looking to put in place a similar model of care.

Advances in the treatment of explicit water molecules in docking and binding free energy calculations.

PubMed

Hu, Xiao; Maffucci, Irene; Contini, Alessandro

2018-05-13

The inclusion of direct effects mediated by water during the ligand-receptor recognition is a hot-topic of modern computational chemistry applied to drug discovery and development. Docking or virtual screening with explicit hydration is still debatable, despite the successful cases that have been presented in the last years. Indeed, how to select the water molecules that will be included in the docking process or how the included waters should be treated remain open questions. In this review, we will discuss some of the most recent methods that can be used in computational drug discovery and drug development when the effect of a single water, or of a small network of interacting waters, needs to be explicitly considered. Here, we analyse software to aid the selection, or to predict the position, of water molecules that are going to be explicitly considered in later docking studies. We also present software and protocols able to efficiently treat flexible water molecules during docking, including examples of applications. Finally, we discuss methods based on molecular dynamics simulations that can be used to integrate docking studies or to reliably and efficiently compute binding energies of ligands in presence of interfacial or bridging water molecules. Software applications aiding the design of new drugs that exploit water molecules, either as displaceable residues or as bridges to the receptor, are constantly being developed. Although further validation is needed, workflows that explicitly consider water will probably become a standard for computational drug discovery soon. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

Bridging barriers to health promotion: a feasibility pilot study of the 'Promoting Aging Migrants' Capabilities study'.

PubMed

Lood, Qarin; Gustafsson, Susanne; Dahlin Ivanoff, Synneve

2015-08-01

Improving the possibilities for ageing persons to take control over their health is an increasingly important public health issue. Health promotion has previously been visualized to succeed with this goal, but research has primarily focused on ageing persons who are native-born, leaving the generalizability to persons who are foreign-born unexplored. Therefore, as part of the development of a larger health promotion initiative for ageing persons who have experienced migration, this study aimed to assess the feasibility of an adapted protocol. The specific feasibility objectives were to assess recruitment procedure, retention rates, study questionnaire administration and variability of collected data. Forty persons who were ≥70 years, and who had migrated from Finland, Bosnia and Herzegovina, Croatia, Montenegro or Serbia to Sweden were randomly allocated to a health promotion programme or a control group. The programme was linguistically adapted with regard to translated information material, bilingual health professionals and evaluators, and a person-centred approach was applied to both programme development and provision. The data analysis was explorative and descriptive. The results visualized structural and linguistic barriers to recruitment and study questionnaire administration, and describe strategies for how to bridge them. Retention rates and data variability were satisfying. Calling for iterative and pragmatic programme design, the findings describe how to move towards a more inclusive health care environment. Person-centred and bilingual approaches with attention to the possibilities for building authentic relationships between participants and providers are emphasized, and a structured methodology for developing study questionnaires is suggested. © 2015 John Wiley & Sons, Ltd.

Skeletal muscle work efficiency with age: the role of non-contractile processes.

PubMed

Layec, Gwenael; Hart, Corey R; Trinity, Joel D; Le Fur, Yann; Jeong, Eun-Kee; Richardson, Russell S

2015-02-01

Although skeletal muscle work efficiency probably plays a key role in limiting mobility of the elderly, the physiological mechanisms responsible for this diminished function remain incompletely understood. Thus, in the quadriceps of young (n=9) and old (n=10) subjects, we measured the cost of muscle contraction (ATP cost) with 31P-magnetic resonance spectroscopy (31P-MRS) during (i) maximal intermittent contractions to elicit a metabolic demand from both cross-bridge cycling and ion pumping and (ii) a continuous maximal contraction to predominantly tax cross-bridge cycling. The ATP cost of the intermittent contractions was significantly greater in the old (0.30±0.22 mM·min-1·N·m-1) compared with the young (0.13±0.03 mM·min-1·N·m-1, P<0.05). In contrast, at the end of the continuous contraction protocol, the ATP cost in the old (0.10±0.07 mM·min-1·N·m-1) was not different from the young (0.06±0.02 mM·min-1·N·m-1, P=0.2). In addition, the ATP cost of the intermittent contractions correlated significantly with the single leg peak power of the knee-extensors assessed during incremental dynamic exercise (r=-0.55; P<0.05). Overall, this study reveals an age-related increase in the ATP cost of contraction, probably mediated by an excessive energy demand from ion pumping, which probably contributes to both the decline in muscle efficiency and functional capacity associated with aging.

Exploring of PST-TBPM in Monitoring Bridge Dynamic Deflection in Vibration

NASA Astrophysics Data System (ADS)

Zhang, Guojian; Liu, Shengzhen; Zhao, Tonglong; Yu, Chengxin

2018-01-01

This study adopts digital photography to monitor bridge dynamic deflection in vibration. Digital photography used in this study is based on PST-TBPM (photographing scale transformation-time baseline parallax method). Firstly, a digital camera is used to monitor the bridge in static as a zero image. Then, the digital camera is used to monitor the bridge in vibration every three seconds as the successive images. Based on the reference system, PST-TBPM is used to calculate the images to obtain the bridge dynamic deflection in vibration. Results show that the average measurement accuracies are 0.615 pixels and 0.79 pixels in X and Z direction. The maximal deflection of the bridge is 7.14 pixels. PST-TBPM is valid in solving the problem-the photographing direction not perpendicular to the bridge. Digital photography used in this study can assess the bridge health through monitoring the bridge dynamic deflection in vibration. The deformation trend curves depicted over time also can warn the possible dangers.

Evaluation of a Summer Bridge: Critical Component of the Leadership 2.0 Program.

PubMed

Pritchard, Tracy J; Perazzo, Joseph D; Holt, Julie A; Fishback, Benjamin P; McLaughlin, Michaela; Bankston, Karen D; Glazer, Greer

2016-04-01

Summer bridges facilitate the transition from high school to college. Although many schools employ summer bridges, few have published outcomes. This article's purpose is to share preconceptions of college by underrepresented and disadvantaged nursing students and describe important elements and long-term impact of a summer bridge, a component of the Leadership 2.0 program. A longitudinal study design was used to collect baseline, short-term, and long-term post-summer bridge data. Methods included pre- and postsurveys, interviews, and focus groups. After bridge completion, students felt more prepared for the nursing program. Students ranked socialization components as most important. The summer bridge had lasting impact through the first year, where grade point average and retention of underrepresented and disadvantaged bridge students was comparable to the majority first-year students. The summer bridge was effective in preparing nursing students for the first year of college. Through holistic evaluation, unique aspects of socialization critical to student success were uncovered. Copyright 2016, SLACK Incorporated.

The effects of prone bridge exercise on trunk muscle thickness in chronic low back pain patients.

PubMed

Kong, Yong-Soo; Lee, Woo-Jin; Park, Seol; Jang, Gwon-Uk

2015-07-01

[Purpose] This study aimed to investigate the effects of prone bridge exercise on trunk muscle thickness. [Subjects and Methods] Thirty-seven chronic low back pain patients participated in this study. Each participant was randomly assigned to one of three exercise groups, namely, a prone bridge exercise group, supine bridge exercise on a Swiss ball group, and supine bridge exercise group. The thicknesses of the transverse abdominis (TrA), internal oblique (IO), and external oblique (EO) were measured using ultrasound. [Results] After eight weeks of training, the three groups showed significant increases in the thicknesses of the TrA, IO, and EO. Among the groups, TrA and IO showed significantly different muscle thicknesses. [Conclusion] The prone bridge exercise significantly affected the thicknesses of the TrA, IO, and EO unlike the supine bridge exercises. Based on the results of this study, the prone bridge exercise is a more effective method to improve trunk stability than conventional supine bridge exercises.

The South Carolina bridge-scour envelope curves

USGS Publications Warehouse

Benedict, Stephen T.; Feaster, Toby D.; Caldwell, Andral W.

2016-09-30

The U.S. Geological Survey, in cooperation with the South Carolina Department of Transportation, conducted a series of three field investigations to evaluate historical, riverine bridge scour in the Piedmont and Coastal Plain regions of South Carolina. These investigations included data collected at 231 riverine bridges, which lead to the development of bridge-scour envelope curves for clear-water and live-bed components of scour. The application and limitations of the South Carolina bridge-scour envelope curves were documented in four reports, each report addressing selected components of bridge scour. The current investigation (2016) synthesizes the findings of these previous reports into a guidance manual providing an integrated procedure for applying the envelope curves. Additionally, the investigation provides limited verification for selected bridge-scour envelope curves by comparing them to field data collected outside of South Carolina from previously published sources. Although the bridge-scour envelope curves have limitations, they are useful supplementary tools for assessing the potential for scour at riverine bridges in South Carolina.

1. Elkmont vehicle bridge at Elkmont Campground, galvanized corrugated arch. ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Elkmont vehicle bridge at Elkmont Campground, galvanized corrugated arch. - Great Smoky Mountains National Park Roads & Bridges, Elkmont Vehicle Bridge, Spanning Little River at Elkmont Campground, Gatlinburg, Sevier County, TN

Developing deterioration models for Nebraska bridges.

DOT National Transportation Integrated Search

2011-07-01

Nebraska Bridge Management System (NBMS) was developed in 1999 to assist in optimizing budget allocation for : the maintenance, rehabilitation and replacement needs of highway bridges. This requires the prediction of bridge : deterioration to calcula...

View of east elevation of Parryville Bridge (S.R. 2008, section ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

View of east elevation of Parryville Bridge (S.R. 2008, section 01B bridge) looking southwest, showing substructure - Parryville Bridge, State Route 2008 over Pohapoco Creek, Parryville, Carbon County, PA

View of west elevation of Parryville Bridge (S.R. 2008, section ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

View of west elevation of Parryville Bridge (S.R. 2008, section 01B Bridge) looking southeast, showing substructure. - Parryville Bridge, State Route 2008 over Pohapoco Creek, Parryville, Carbon County, PA

2. 3/4 VIEW OF NACHES RIVER BRIDGE, LOOKING SOUTHWEST (BURLINGTON ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

2. 3/4 VIEW OF NACHES RIVER BRIDGE, LOOKING SOUTHWEST (BURLINGTON NORTHERN RAILROAD BRIDGE ON EXTREME LEFT) - Yakima Valley Transportation Company Interurban Railroad, Naches River Bridge, Yakima, Yakima County, WA

Highway bridge inspection : state-of-the-practice survey

DOT National Transportation Integrated Search

2001-04-01

The congressionally mandated National Bridge Inspection program requires States to periodically inventory, inspect, and rate all highway bridges on public roads. The National Bridge Inspection Standards, implemented in 1971, prescribe minimum require...

VIEW NORTH, SHOWING SOUTH END OF BRIDGE LOOKING TOWARD VAN ...

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

VIEW NORTH, SHOWING SOUTH END OF BRIDGE LOOKING TOWARD VAN BUREN TOWNSHIP - Belleville Road Bridge, Spanning the Flat River at Burroughs Drive (replaced Burroughs Street Bridge), Lowell, Kent County, MI

Movable bridge maintenance monitoring : [technical summary].

DOT National Transportation Integrated Search

2013-10-01

Maintenance costs for movable bridges are considerably higher than for fixed bridges, mostly because of the complex interaction of mechanical, electrical, and structural components. Malfunction of any component can cause unexpected failure of bridge ...

Bridge permeameter

DOEpatents

Graf, D.C.; Warpinski, N.R.

1996-08-13

A system is described for single-phase, steady-state permeability measurements of porous rock which utilizes a fluid bridge arrangement analogous to a Wheatstone bridge. The arms of the bridge contain the sample and calibrated flow resistors. 8 figs.

Seismic response of precast segmental bridge superstructures.

DOT National Transportation Integrated Search

2006-12-01

Precast segmental construction of bridges can accelerate construction and minimize the cost of bridges in highly congested urban environments and environmentally sensitive regions. Despite their proven benefits, the use of precast segmental bridges i...

23 CFR 650.805 - Bridges not requiring a USCG permit.

Code of Federal Regulations, 2013 CFR

2013-04-01

... OPERATIONS BRIDGES, STRUCTURES, AND HYDRAULICS Navigational Clearances for Bridges § 650.805 Bridges not... Engineers if the susceptibility to improvement for navigation of the water of concern is unknown and shall...

23 CFR 650.805 - Bridges not requiring a USCG permit.

Code of Federal Regulations, 2011 CFR

2011-04-01

... OPERATIONS BRIDGES, STRUCTURES, AND HYDRAULICS Navigational Clearances for Bridges § 650.805 Bridges not... Engineers if the susceptibility to improvement for navigation of the water of concern is unknown and shall...

23 CFR 650.805 - Bridges not requiring a USCG permit.

Code of Federal Regulations, 2014 CFR

2014-04-01

... OPERATIONS BRIDGES, STRUCTURES, AND HYDRAULICS Navigational Clearances for Bridges § 650.805 Bridges not... Engineers if the susceptibility to improvement for navigation of the water of concern is unknown and shall...

23 CFR 650.805 - Bridges not requiring a USCG permit.

Code of Federal Regulations, 2010 CFR

2010-04-01

... OPERATIONS BRIDGES, STRUCTURES, AND HYDRAULICS Navigational Clearances for Bridges § 650.805 Bridges not... Engineers if the susceptibility to improvement for navigation of the water of concern is unknown and shall...

23 CFR 650.805 - Bridges not requiring a USCG permit.

Code of Federal Regulations, 2012 CFR

2012-04-01

... OPERATIONS BRIDGES, STRUCTURES, AND HYDRAULICS Navigational Clearances for Bridges § 650.805 Bridges not... Engineers if the susceptibility to improvement for navigation of the water of concern is unknown and shall...

Bridge permeameter

DOE Office of Scientific and Technical Information (OSTI.GOV)

Graf, D.C.; Warpinski, N.R.

A system is described for single-phase, steady-state permeability measurements of porous rock which utilizes a fluid bridge arrangement analogous to a Wheatstone bridge. The arms of the bridge contain the sample and calibrated flow resistors. 8 figs.

Tungsten bridge for the low energy ignition of explosive and energetic materials

DOEpatents

Benson, D.A.; Bickes, R.W. Jr.; Blewer, R.S.

1990-12-11

A tungsten bridge device for the low energy ignition of explosive and energetic materials is disclosed. The device is fabricated on a silicon-on-sapphire substrate which has an insulating bridge element defined therein using standard integrated circuit fabrication techniques. Then, a thin layer of tungsten is selectively deposited on the silicon bridge layer using chemical vapor deposition techniques. Finally, conductive lands are deposited on each end of the tungsten bridge layer to form the device. It has been found that this device exhibits substantially shorter ignition times than standard metal bridges and foil igniting devices. In addition, substantially less energy is required to cause ignition of the tungsten bridge device of the present invention than is required for common metal bridges and foil devices used for the same purpose. 2 figs.

Determination of the bridge maintenance and rehabilitation priority scale in kabupaten Pinrang

NASA Astrophysics Data System (ADS)

Nurdin, Asrul; Kristiawan, S. A.; Dewi, Handayani

2017-01-01

This study attempts to get the support system to help stakeholders and the decision makers in the determination of priorities the maintenance and rehabilitation of the Bridge.The location of the study is done in Kabupaten Pinrang. Bridge damage value is specified using assessment standard Bridge Management System (BMS). There are 13 Bridges by details as follows: good condition with the condition 1 in 6 Bridge, damaged with the condition two as many as five fruit Bridges and there are two Bridges by value condition of three which means need handling rehabilitation. From our observation examination Bridges and it has been obtained the results of then afterward determined the priority scale by using the method Analytic Hierarchy Process. The discussion or interview of 27 respondents in completion question to determines the priorities of handling bridges by three (3) criteria and three sub- criteria with weights each: a condition of damage with weights 0,491 or amounting to 49,1 % followed by criteria policy with weights 0,324 % then criteria volume traffic weight of 0,185 or 18.5 %. Based on the results of this can be concluded that the implementation of a method of Analytic Hierarchy Processing is effective in determining the scale of priorities for the stakeholders. Having acquired value bridge condition and weights of the assessment results of the, then is needed to Analysis of spatial use application ArcGIS to obtain information condition Bridge Map.

Numerical simulation of wind-sand movement in the reversed flow region of a sand dune with a bridge built downstream.

PubMed

He, Wei; Huang, Ning; Xu, Bin; Wang, Wenbo

2018-04-23

A bridge built inside the reversed flow region of a sand dune will change the characteristics of wind-sand movement in this region. The Reynolds-averaged Navier-Stokes simulation and discrete particle tracing are used to simulate the wind-sand movement around a sand dune with a bridge built inside the reversed region. Three cases with different bridge positions are studied. The results show that 1) compared with the isolated dune case, a tall bridge built at the leeward toe leads to an increase in the deposition rate on the leeward slope and a longer reversed flow region downstream of the sand dune; meanwhile, the high speed of crosswind on the bridge indicates that some measures should be taken to protect trains from strong crosswind; 2) a low bridge at the leeward toe has little effect on the sand deposition and reversed flow region of the dune; however, low sand transport rate and crosswind speed on the bridge show that anti-crosswind/sand measures should be taken according to the actual situation and 3) a low bridge on the leeward slope has little effect on the length of reversed flow region, however, high crosswind speed and sand flux on the bridge reveal the need of anti-crosswind/sand measures on the bridge. Moreover, the bridges in the reversed flow region increase the sand flux near the leeward crest; as a result, the moving patterns of the sand dune are changed.

High extinction ratio terahertz wire-grid polarizers with connecting bridges on quartz substrates.

PubMed

Cetnar, John S; Vangala, Shivashankar; Zhang, Weidong; Pfeiffer, Carl; Brown, Elliott R; Guo, Junpeng

2017-03-01

A terahertz (THz) wire-grid polarizer with metallic bridges on a quartz substrate was simulated, fabricated, and tested. The device functions as a wide-band polarizer to incident THz radiation. In addition, the metallic bridges permit the device to function as a transparent electrode when a DC bias is applied to it. Three design variations of the polarizer with bridges and a polarizer without bridges were studied. Results show the devices with bridges have average s-polarization transmittance of less than -3  dB and average extinction ratios of approximately 40 dB across a frequency range of 220-990 GHz and thus are comparable to a polarizer without bridges.

33 CFR 401.52 - Limit of approach to a bridge.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 3 2011-07-01 2011-07-01 false Limit of approach to a bridge... approach to a bridge. (a) No vessel shall pass the limit of approach sign at any movable bridge until the bridge is in a fully open position and the signal light shows green. (b) No vessel shall pass the limit...

23 CFR 661.57 - How is a list of deficient bridges to be generated?

Code of Federal Regulations, 2011 CFR

2011-04-01

... 23 Highways 1 2011-04-01 2011-04-01 false How is a list of deficient bridges to be generated? 661... AND TRAFFIC OPERATIONS INDIAN RESERVATION ROAD BRIDGE PROGRAM § 661.57 How is a list of deficient bridges to be generated? (a) In consultation with the BIA, a list of deficient BIA IRR bridges will be...

49 CFR Appendix A to Part 237 - Supplemental Statement of Agency Policy on the Safety of Railroad Bridges

Code of Federal Regulations, 2014 CFR

2014-10-01

... for the design of a bridge can generally be used to determine and rate the load capacity of a bridge... from the service loads can be correlated to the stresses for which the bridge was designed or rated. 3... bridge should keep design, construction, maintenance and repair records readily accessible to permit the...