Urinary NGAL, KIM-1 and L-FABP concentrations in antenatal hydronephrosis.

PubMed

Noyan, Aytul; Parmaksiz, Gonul; Dursun, Hasan; Ezer, Semire Serin; Anarat, Ruksan; Cengiz, Nurcan

2015-10-01

The clinical tests currently in use for obstructive nephropathy (such as renal ultrasonography, differential radionuclide renal scans and urinary creatinine concentration data) are not efficient predictors of the subsequent clinical course. Novel and simple biomarkers are required which, if proven, could be clinically beneficial in determining if a patient is eligible for surgery or reno-protective therapy. More recently, the interest of clinicians has focused on the potential of urinary neutrophil gelatinase-associated lipocalin (uNGAL), urinary kidney injury molecule-1 (uKIM-1) and urinary liver-type fatty acid-binding proteins (uL-FABP) as biomarkers for renal function in children with hydronephrosis (HN). The purpose of this study was to investigate possible clinical applications of uNGAL, uKIM-1 and uL-FABP as beneficial non-invasive biomarkers to determine whether or not surgical intervention is required in children with HN. Renal ultrasonography and radionuclide renal scans were used as diagnostic tools to detect HN. Patients were divided into two groups based on the antero-posterior diameter of their renal pelvis and the presence of dysfunction. Group 1 included 26 children with severe HN (with dysfunction), and group 2 consisted of 36 children with mild HN (without dysfunction). Urine samples were collected from 62 children with HN and 20 healthy children. Hydronephrosis was more common in males than in females, with a male to female ratio of 9:1 in the study sample. The incidence of left kidney involvement (32 patients) was slightly higher than right kidney involvement (28 patients). Compared with controls and group 2, the ratio of uNGAL to creatinine was significantly higher in group 1 (p < 0.05). The biomarker uNGAL/Cr exhibited fairly good diagnostic accuracy, with an area under the curve of 0.68 [95% confidence interval 0.6-0.7] and an optimal cut-off value of 0.16 ng/mg Cr (sensitivity 58%, specificity 75%) (p < 0.05). There was a positive

Loran-C digital word generator for use with a KIM-1 microprocessor system

NASA Technical Reports Server (NTRS)

Nickum, J. D.

1977-01-01

The problem of translating the time of occurrence of received Loran-C pulses into a time, referenced to a particular period of occurrence is addressed and applied to the design of a digital word generator for a Loran-C sensor processor package. The digital information from this word generator is processed in a KIM-1 microprocessor system which is based on the MOS 6502 CPU. This final system will consist of a complete time difference sensor processor for determining position information using Loran-C charts. The system consists of the KIM-1 microprocessor module, a 4K RAM memory board, a user interface, and the Loran-C word generator.

Genome sequencing and analysis of Yersina pestis KIM D27, an avirulent strain exempt from select agent regulation.

PubMed

Losada, Liliana; Varga, John J; Hostetler, Jessica; Radune, Diana; Kim, Maria; Durkin, Scott; Schneewind, Olaf; Nierman, William C

2011-04-29

Yersinia pestis is the causative agent of the plague. Y. pestis KIM 10+ strain was passaged and selected for loss of the 102 kb pgm locus, resulting in an attenuated strain, KIM D27. In this study, whole genome sequencing was performed on KIM D27 in order to identify any additional differences. Initial assemblies of 454 data were highly fragmented, and various bioinformatic tools detected between 15 and 465 SNPs and INDELs when comparing both strains, the vast majority associated with A or T homopolymer sequences. Consequently, Illumina sequencing was performed to improve the quality of the assembly. Hybrid sequence assemblies were performed and a total of 56 validated SNP/INDELs and 5 repeat differences were identified in the D27 strain relative to published KIM 10+ sequence. However, further analysis showed that 55 of these SNP/INDELs and 3 repeats were errors in the KIM 10+ reference sequence. We conclude that both 454 and Illumina sequencing were required to obtain the most accurate and rapid sequence results for Y. pestis KIMD27. SNP and INDELS calls were most accurate when both Newbler and CLC Genomics Workbench were employed. For purposes of obtaining high quality genome sequence differences between strains, any identified differences should be verified in both the new and reference genomes.

A Response to Ling-chi Wang, Elaine Kim, and Sucheng Chan.

ERIC Educational Resources Information Center

Takaki, Ronald

1990-01-01

Replies to every criticism in the foregoing essays of Ling-chi Wang, Elaine Kim, and Sucheng Chan. Endorses Chan's call for more in-depth research. Explains that the size of the book and the number of sources prevented closer annotation in the first edition. (DM)

The New North Korean Problem: History and Responsibilities in the Age of Kim Jong Un

DTIC Science & Technology

2012-03-29

Unfortunately, none of these has come close to fruition. 14 Geun- hye Park , a member of the National Assembly of the Republic of Korea, describes a key...Korean Spring?,” The Washington Quarterly, Winter, 2012. 38 Cha and Anderson, 10. 39 Kim 16. 40 Kim 34. 41 Bluth 88. 42 Geun- Hye Park , “A New Kind of...Griffin, 2004. Park , Geun Hye . “A New Kind of Korea: Building Trust Between Seoul and Pyongyang.” Foreign Affairs 90, no.5(September-October 2011

Clinical utility of urine kidney injury molecule-1 (KIM-1) and gamma-glutamyl transferase (GGT) in the diagnosis of canine acute kidney injury.

PubMed

Lippi, Ilaria; Perondi, F; Meucci, V; Bruno, B; Gazzano, V; Guidi, G

2018-06-01

The aim of the present study was to evaluate the sensitivity and specificity of urine KIM-1 and urine GGT for the detection of naturally-occurring AKI, compared to healthy control dogs, dogs with stable chronic kidney disease (CKD), and dogs with lower urinary tract disorders (LUTD). The study included AKI grade 1 (n = 21), AKI grade 2 to 5 (n = 11), stable CKD (n = 11), LUTD (n = 15), and healthy dogs (n = 37). Urine KIM-1 (ng/mg) and GGT (U/l) were normalized to urine creatinine (uCr). Statistically significant difference in KIM/uCr (p = 0.0007) and GGT/uCr (p < 0.0001) was found among the study groups. Area under the curve (AUC) for KIM-1/uCr and GGT/uCr as predictors of AKI was 0.81 and 0.91 respectively. Values of KIM-1/uCr of 0.73 ng/mg and of GGT/uCr of 54.33 showed the best combination of sensitivity and specificity (75% and 75.6%; 85.7% and 89.1% respectively). A significant positive correlation (p < 0.0001) between KIM-1/uCr and GGT/uCr was found. Both urine KIM-1/uCr and GGT/uCr seemed to be potentially good markers for the diagnosis of AKI. Dogs with AKI showed significantly higher levels of urine KIM-1/uCr and urine GGT/uCr, compared with healthy dogs. Caution should be used in the evaluation of elevated urine KIM-1/uCr and GGT/uCr in dogs with pre-existing CKD and/or LUTD. Urine KIM-1/uCr and GGT/uCr might have a significant clinical utility, as complementary test, particularly in diagnosis early, non-azotemic stages of AKI.

Genome Sequencing and Analysis of Yersina pestis KIM D27, an Avirulent Strain Exempt from Select Agent Regulation

PubMed Central

Losada, Liliana; Varga, John J.; Hostetler, Jessica; Radune, Diana; Kim, Maria; Durkin, Scott; Schneewind, Olaf; Nierman, William C.

2011-01-01

Yersinia pestis is the causative agent of the plague. Y. pestis KIM 10+ strain was passaged and selected for loss of the 102 kb pgm locus, resulting in an attenuated strain, KIM D27. In this study, whole genome sequencing was performed on KIM D27 in order to identify any additional differences. Initial assemblies of 454 data were highly fragmented, and various bioinformatic tools detected between 15 and 465 SNPs and INDELs when comparing both strains, the vast majority associated with A or T homopolymer sequences. Consequently, Illumina sequencing was performed to improve the quality of the assembly. Hybrid sequence assemblies were performed and a total of 56 validated SNP/INDELs and 5 repeat differences were identified in the D27 strain relative to published KIM 10+ sequence. However, further analysis showed that 55 of these SNP/INDELs and 3 repeats were errors in the KIM 10+ reference sequence. We conclude that both 454 and Illumina sequencing were required to obtain the most accurate and rapid sequence results for Y. pestis KIMD27. SNP and INDELS calls were most accurate when both Newbler and CLC Genomics Workbench were employed. For purposes of obtaining high quality genome sequence differences between strains, any identified differences should be verified in both the new and reference genomes. PMID:21559501

[The diagnostic importance of the new marker KIM-1 in kidney damage].

PubMed

Marchewka, Zofia; Płonka, Joanna

2013-07-24

In recent years, the rapid development of scientific research led to the introduction of strategies based on new markers that allow for estimation of the latent disease period before the clinical symptoms of actual kidney failure are revealed. The experimental tests carried out on animals and cell lines derived from the proximal tubule have made possible the detection of genes that are induced early after hypoxia. The protein products of these genes can be considered as useful markers for the diagnosis of renal failure. The induction of gene KIM-1 (called Kidney Injury Molecule-1) results in the formation of protein that can be considered as a diagnostic marker. This work describes the data on the structure, biological function and importance of determining the concentrations of KIM-1 in the diagnosis of drug-induced toxicity and kidney damage.

KIM-1 Is a Potential Urinary Biomarker of Obstruction: Results from a Prospective Cohort Study.

PubMed

Olvera-Posada, Daniel; Dayarathna, Thamara; Dion, Marie; Alenezi, Husain; Sener, Alp; Denstedt, John D; Pautler, Stephen E; Razvi, Hassan

2017-02-01

Partial or complete obstruction of the urinary tract is a common and challenging urological condition that may occur in patients of any age. Serum creatinine is the most commonly used method to evaluate global renal function, although it has low sensitivity for early changes in the glomerular filtration rate or unilateral renal pathology. Hence, finding another measurable parameter that reflects the adaptation of the renal physiology to these circumstances is important. Several recent studies have assessed the use of new biomarkers of acute kidney injury (AKI), but the information among patients with stone disease and those with obstructive uropathy is limited. A prospective cohort study was conducted to determine the urinary levels of kidney injury molecule-1 (KIM-1), Total and Monomeric neutrophil gelatinase-associated lipocalin (NGAL) in patients with hydronephrosis secondary to renal stone disease, congenital ureteropelvic junction obstruction or ureteral stricture. Comparison between patients with hydronephrosis and no hydronephrosis was carried out along with correlation analysis to detect factors associated with biomarker expression. Urinary levels of KIM-1 significantly decreased after hydronephrosis treatment in patients with unilateral obstruction (1.19 ng/mL vs 0.76 ng/mL creatinine, p = 0.002), additionally KIM-1 was significantly higher in patients with hydronephrosis compared to stone disease patients without radiological evidence of obstruction (1.19 vs 0.64, p = 0.006). Total and Monomeric NGAL showed a moderate correlation with the presence of leukocyturia. We found that a KIM-1 value of 0.735 ng/mg creatinine had a sensitivity of 75% and specificity of 67% to predict the presence of hydronephrosis in preoperative studies (95% CI 0.58-0.87, p = 0.006). Our results show that KIM-1 is a promising biomarker of subclinical AKI associated with hydronephrosis in urological patients. NGAL values were influenced by the presence of

Kim Jong IL and North Korea: The Leader and the System

DTIC Science & Technology

2006-03-01

defined in Title 17, United States Code , section 101. As such, it is in the public domain, and under the provisions of Title 17, United States Code ...diplomat.35 Kim probably also had a major hand in designing the massive Nuremburg -style rally at the stadium that Albright witnessed the day before

The KIM-family protein-tyrosine phosphatases use distinct reversible oxidation intermediates: Intramolecular or intermolecular disulfide bond formation.

PubMed

Machado, Luciana E S F; Shen, Tun-Li; Page, Rebecca; Peti, Wolfgang

2017-05-26

The kinase interaction motif (KIM) family of protein-tyrosine phosphatases (PTPs) includes hematopoietic protein-tyrosine phosphatase (HePTP), striatal-enriched protein-tyrosine phosphatase (STEP), and protein-tyrosine phosphatase receptor type R (PTPRR). KIM-PTPs bind and dephosphorylate mitogen-activated protein kinases (MAPKs) and thereby critically modulate cell proliferation and differentiation. PTP activity can readily be diminished by reactive oxygen species (ROS), e.g. H 2 O 2 , which oxidize the catalytically indispensable active-site cysteine. This initial oxidation generates an unstable sulfenic acid intermediate that is quickly converted into either a sulfinic/sulfonic acid (catalytically dead and irreversible inactivation) or a stable sulfenamide or disulfide bond intermediate (reversible inactivation). Critically, our understanding of ROS-mediated PTP oxidation is not yet sufficient to predict the molecular responses of PTPs to oxidative stress. However, identifying distinct responses will enable novel routes for PTP-selective drug design, important for managing diseases such as cancer and Alzheimer's disease. Therefore, we performed a detailed biochemical and molecular study of all KIM-PTP family members to determine their H 2 O 2 oxidation profiles and identify their reversible inactivation mechanism(s). We show that despite having nearly identical 3D structures and sequences, each KIM-PTP family member has a unique oxidation profile. Furthermore, we also show that whereas STEP and PTPRR stabilize their reversibly oxidized state by forming an intramolecular disulfide bond, HePTP uses an unexpected mechanism, namely, formation of a reversible intermolecular disulfide bond. In summary, despite being closely related, KIM-PTPs significantly differ in oxidation profiles. These findings highlight that oxidation protection is critical when analyzing PTPs, for example, in drug screening. © 2017 by The American Society for Biochemistry and Molecular Biology

Evaluation of KIM-1 as an early biomarker of snakebite-induced AKI in mice.

PubMed

Dantas, Rodrigo Tavares; Sampaio, Tiago Lima; Lima, Dânya Bandeira; Bezerra de Menezes, Ramon Róseo Paula Pessoa; Canuto, Jader Almeida; Toyama, Marcos Hikari; Evangelista, Janaína Serra Azul Monteiro; Martins, Alice Maria Costa

2018-06-14

Acute kidney injury (AKI) is one of the most important complications of bothropic poisoning and its early identification remains challenging. The nephrotoxicity of Bothrops insularis venom (BinsV) was previously described by our research group. In this study, we continued to evaluate the effect of BinsV on kidney function in mice and LLC-MK2 proximal tubule cells, evaluating KIM-1 protein as an early AKI biomarker. Male Swiss mice were inoculated with BinsV intramuscularly and observed for 24 h in a metabolic cage model. Urine and blood were collected for biochemical analyses and the kidneys were examined for oxide-reducing balance and submitted to histological analysis. LLC-MK2 cells incubated with BinsV were assessed for cell viability and cell death mechanism by flow cytometry. Histological analysis of the kidneys indicated AKI and the oxide-reducing analyses demonstrated a decreasing in reduced glutathione (GSH) levels and an increasing on Malondialdehyde (MDA) levels. BinsV was cytotoxic to LLC-MK2 and the cytometry analyses suggested necrosis. Within 24 h after the envenomation, urinary creatinine did not increase, but the urinary levels of KIM-1 increased. In conclusion, we found AKI evidence in the kidney tissue and the increase in the KIM-1 levels suggest it can be used as an early AKI biomarker. Copyright © 2018. Published by Elsevier Ltd.

Clinical significance of NGAL and KIM-1 for acute kidney injury in patients with scrub typhus.

PubMed

Sun, In O; Shin, Sung Hye; Cho, A Young; Yoon, Hyun Ju; Chang, Mi Yok; Lee, Kwang Young

2017-01-01

The aim of this study is to investigate the clinical significance of neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) for acute kidney injury (AKI) in patients with scrub typhus. From 2014 to 2015, 145 patients were diagnosed with scrub typhus. Of these, we enrolled 138 patients who were followed up until renal recovery or for at least 3 months. We measured serum and urine NGAL and KIM-1 levels and evaluated prognostic factors affecting scrub typhus-associated AKI. Of the 138 patients, 25 had scrub typhus-associated AKI. The incidence of AKI was 18.1%; of which 11.6%, 4.3%, and 2.2% were classified as risk, injury, and failure, respectively, according to RIFLE criteria. Compared with patients in the non-AKI group, patients in the AKI group were older and showed higher total leukocyte counts and hypoalbuminemia or one or more comorbidities such as hypertension (72% vs 33%, p<0.01), diabetes (40% vs 14%, p<0.01), or chronic kidney disease (32% vs 1%, p<0.01). In addition, serum NGAL values (404± 269 vs 116± 78 ng/mL, P<0.001), KIM-1 values (0.80± 0.52 vs 0.33± 0.68 ng/mL, P<0.001), urine NGAL/creatinine values (371± 672 vs 27± 39 ng/mg, P<0.001) and urine KIM-1/creatinine values (4.04± 2.43 vs 2.38± 1.89 ng/mg, P<0.001) were higher in the AKI group than in the non-AKI group. By multivariate logistic regression, serum NGAL and the presence of chronic kidney disease were significant predictors of AKI. Serum NGAL might be an additive predictor for scrub typhus-associated AKI.

A kidney injury molecule-1 (Kim-1) gene reporter in a mouse artificial chromosome: the responsiveness to cisplatin toxicity in immortalized mouse kidney S3 cells.

PubMed

Kokura, Kenji; Kuromi, Yasushi; Endo, Takeshi; Anzai, Naohiko; Kazuki, Yasuhiro; Oshimura, Mitsuo; Ohbayashi, Tetsuya

2016-10-01

Kidney injury molecule-1 (Kim-1) has been validated as a urinary biomarker for acute and chronic renal damage. The expression of Kim-1 mRNA is also activated by acute kidney injury induced by cisplatin in rodents and humans. To date, the measurement of Kim-1 expression has not fully allowed the detection of in vitro cisplatin nephrotoxicity in immortalized culture cells, such as human kidney-2 cells and immortalized proximal tubular epithelial cells. We measured the augmentation of Kim-1 mRNA expression after the addition of cisplatin using immortalized S3 cells established from the kidneys of transgenic mice harboring temperature-sensitive large T antigen from Simian virus 40. A mouse Kim-1 gene luciferase reporter in conjunction with an Hprt gene reporter detected cisplatin-induced nephrotoxicity in S3 cells. These two reporter genes were contained in a mouse artificial chromosome, and two luciferases that emitted different wavelengths were used to monitor the respective gene expression. However, the Kim-1 reporter gene failed to respond to cisplatin in A9 fibroblast cells that contained the same reporter mouse artificial chromosome, suggesting cell type-specificity for activation of the reporter. We report the feasibility of measuring in vitro cisplatin nephrotoxicity using a Kim-1 reporter gene in S3 cells. © 2016 The Authors. The Journal of Gene Medicine Published by John Wiley & Sons, Ltd.

Social influence of a religious hero: the late Cardinal Stephen Kim Sou-hwan's effect on cornea donation and volunteerism.

PubMed

Bae, Hyuhn-Suhck; Brown, William J; Kang, Seok

2011-01-01

This study examined the mediated influence of a celebrated religious hero in South Korea, Cardinal Stephen Kim, through two forms of involvement--parasocial interaction and identification--on intention toward cornea donation and volunteerism, and it investigated how the news media diffused of his death. A structural equation modeling analysis with a Web-based voluntary survey of more than 1,200 people in South Korea revealed a multistep social influence process, beginning with parasocial interaction with Cardinal Kim, leading to identification with him, which predicted intention toward cornea donation and volunteerism. Additional investigations found that news of Cardinal Kim's death diffused rapidly through media and interpersonal communication. Results of this study demonstrate that religious leaders who achieve a celebrity hero status can prompt public discussion of important issues rather quickly through extensive media coverage, enabling them to promote prosocial behavior and positively affect public health.

North Korea after Kim Chong-il: Leadership Dynamics and Potential Crisis Scenarios

DTIC Science & Technology

2011-11-01

legal responsibility, and with specified procedures , the actual process is different.3 To date, regime dynamics in the Kim Chong-il era have been... procedures and regulations provide the outlines of formal rule, the 3 For a detailed examination of how...was also made an alternate member. It is also worth noting that 10 of the 12 members of the NDC were represented in the new Politburo lineup , thus

Urinary KIM-1, NGAL and L-FABP for the diagnosis of AKI in patients with acute coronary syndrome or heart failure undergoing coronary angiography.

PubMed

Torregrosa, Isidro; Montoliu, Carmina; Urios, Amparo; Andrés-Costa, María Jesús; Giménez-Garzó, Carla; Juan, Isabel; Puchades, María Jesús; Blasco, María Luisa; Carratalá, Arturo; Sanjuán, Rafael; Miguel, Alfonso

2015-11-01

Acute kidney injury (AKI) is a common complication after coronary angiography. Early biomarkers of this disease are needed since increase in serum creatinine levels is a late marker. To assess the usefulness of urinary kidney injury molecule-1 (uKIM-1), neutrophil gelatinase-associated lipocalin (uNGAL) and liver-type fatty acid-binding protein (uL-FABP) for early detection of AKI in these patients, comparing their performance with another group of cardiac surgery patients. Biomarkers were measured in 193 patients, 12 h after intervention. In the ROC analysis, AUC for KIM-1, NGAL and L-FABP was 0.713, 0.958 and 0.642, respectively, in the coronary angiography group, and 0.716, 0.916 and 0.743 in the cardiac surgery group. Urinary KIM-1 12 h after intervention is predictive of AKI in adult patients undergoing coronary angiography, but NGAL shows higher sensitivity and specificity. L-FABP provides inferior discrimination for AKI than KIM-1 or NGAL in contrast to its performance after cardiac surgery. This is the first study showing the predictive capacity of KIM-1 for AKI after coronary angiography. Further studies are still needed to answer relevant questions about the clinical utility of biomarkers for AKI in different clinical settings.

Expression of kidney injury molecule-1 (Kim-1) in relation to necrosis and apoptosis during the early stages of Cd-induced proximal tubule injury

DOE Office of Scientific and Technical Information (OSTI.GOV)

Prozialeck, Walter C.; Edwards, Joshua R.; Lamar, Peter C.

2009-08-01

Cadmium (Cd) is a nephrotoxic industrial and environmental pollutant that causes a generalized dysfunction of the proximal tubule. Kim-1 is a transmembrane glycoprotein that is normally not detectable in non-injured kidney, but is up-regulated and shed into the urine during the early stages of Cd-induced proximal tubule injury. The objective of the present study was to examine the relationship between the Cd-induced increase in Kim-1 expression and the onset of necrotic and apoptotic cell death in the proximal tubule. Adult male Sprague-Dawley rats were treated with 0.6 mg (5.36 {mu}mol) Cd/kg, subcutaneously, 5 days per week for up to 12more » weeks. Urine samples were analyzed for levels of Kim-1 and the enzymatic markers of cell death, lactate dehydrogenase (LDH) and alpha-glutathione-S-transferase ({alpha}-GST). In addition, necrotic cells were specifically labeled by perfusing the kidneys in situ with ethidium homodimer using a procedure that has been recently developed and validated in the Prozialeck laboratory. Cryosections of the kidneys were also processed for the immunofluorescent visualization of Kim-1 and the identification of apoptotic cells by TUNEL labeling. Results showed that significant levels of Kim-1 began to appear in the urine after 6 weeks of Cd treatment, whereas the levels of total protein, {alpha}-GST and LDH were not increased until 8-12 weeks. Results of immunofluorescence labeling studies showed that after 6 weeks and 12 weeks, Kim-1 was expressed in the epithelial cells of the proximal tubule, but that there was no increase in the number of necrotic cells, and only a modest increase in the number of apoptotic cells at 12 weeks. These results indicate that the Cd-induced increase in Kim-1 expression occurs before the onset of necrosis and at a point where there is only a modest level of apoptosis in the proximal tubule.« less

The first clinical implementation of a real-time six degree of freedom target tracking system during radiation therapy based on Kilovoltage Intrafraction Monitoring (KIM).

PubMed

Nguyen, Doan Trang; O'Brien, Ricky; Kim, Jung-Ha; Huang, Chen-Yu; Wilton, Lee; Greer, Peter; Legge, Kimberley; Booth, Jeremy T; Poulsen, Per Rugaard; Martin, Jarad; Keall, Paul J

2017-04-01

We present the first clinical implementation of a real-time six-degree of freedom (6DoF) Kilovoltage Intrafraction Monitoring (KIM) system which tracks the cancer target translational and rotational motions during treatment. The method was applied to measure and correct for target motion during stereotactic body radiotherapy (SBRT) for prostate cancer. Patient: A patient with prostate adenocarcinoma undergoing SBRT with 36.25Gy, delivered in 5 fractions was enrolled in the study. 6DoF KIM technology: 2D positions of three implanted gold markers in each of the kV images (125kV, 10mA at 11Hz) were acquired continuously during treatment. The 2D→3D target position estimation was based on a probability distribution function. The 3D→6DoF target rotation was calculated using an iterative closest point algorithm. The accuracy and precision of the KIM method was measured by comparing the real-time results with kV-MV triangulation. Of the five treatment fractions, KIM was utilised successfully in four fractions. The intrafraction prostate motion resulted in three couch shifts in two fractions when the prostate motion exceeded the pre-set action threshold of 2mm for more than 5s. KIM translational accuracy and precision were 0.3±0.6mm, -0.2±0.3mm and 0.2±0.7mm in the Left-Right (LR), Superior-Inferior (SI) and Anterior-Posterior (AP) directions, respectively. The KIM rotational accuracy and precision were 0.8°±2.0°, -0.5°±3.3° and 0.3°±1.6° in the roll, pitch and yaw directions, respectively. This treatment represents, to the best of our knowledge, the first time a cancer patient's tumour position and rotation have been monitored in real-time during treatment. The 6 DoF KIM system has sub-millimetre accuracy and precision in all three translational axes, and less than 1° accuracy and 4° precision in all three rotational axes. Copyright © 2017 Elsevier B.V. All rights reserved.

A Misleading Review of Response Bias: Comment on McGrath, Mitchell, Kim, and Hough (2010)

ERIC Educational Resources Information Center

Rohling, Martin L.; Larrabee, Glenn J.; Greiffenstein, Manfred F.; Ben-Porath, Yossef S.; Lees-Haley, Paul; Green, Paul; Greve, Kevin W.

2011-01-01

In the May 2010 issue of "Psychological Bulletin," R. E. McGrath, M. Mitchell, B. H. Kim, and L. Hough published an article entitled "Evidence for Response Bias as a Source of Error Variance in Applied Assessment" (pp. 450-470). They argued that response bias indicators used in a variety of settings typically have insufficient data to support such…

Strategic implications of the succession of Kim Jong IL for US foreign policy towards North Korea. Master`s thesis, 2 August 1994-2 June 1995

DOE Office of Scientific and Technical Information (OSTI.GOV)

McElree, J.A.

1995-06-02

This study analyzes the strategic implications of the dynastic succession of Kim Jong IL for U.S. foreign policy towards North Korea. The proliferation of nuclear weapons by North Korea threatens vital U.S. interests in Northeast Asia and challenges U.S. regional and global leadership. In order to properly respond to the North Korean nuclear threat, it is essential to understand the man who will dictate North Korean actions--Kim Jong IL. The study examines Kim Jong Il`s background, training, experience, personality, leadership characteristics, and the challenges he will face. The analysis of Kim Jong IL indicates that he is a rational actormore » who has and will continue to act in a rational manner in pursuit of his desired ends. The framework for analysis is the Strategic Estimate Process. Alternative courses of action are developed using the four elements of national power. The study identifies the strategic implications of probable North Korean actions and recommends appropriate U.S. courses of action on the basis of feasibility, acceptability, and suitability in achieving U.S. objectives in support of U.S. interests.« less

Generalized variational approach to Kim-Gordon electron gas theory for ionic crystals

NASA Astrophysics Data System (ADS)

Ivanov, O. V.; Maksimov, E. G.

1996-01-01

The generalized approach to the Kim-Gordon electron gas model is proposed. The total density of a crystal is considered as a superposition of densities of individual overlapping ions. The possible distortions of individual ion densities are calculated in the presence of some auxiliary external potentials. The real values of these distortions are calculated by a variational method from the minimum total energy of a crystal. The proper prescription of the ion self-energy with a distorted density is given using the method elaborated in the nonequilibrium thermodynamics. Some examples of the calculation for phonon frequencies are presented and demonstrate a good agreement with experimental data.

"The Day All of the Different Parts of Me Can Come Along": Intersectionality and U.S. Third World Feminism in the Poetry of Pat Parker and Willyce Kim.

PubMed

Van Ausdall, Mimi Iimuro

2015-01-01

This article brings to light the poetry of Pat Parker and Willyce Kim, two key figures within the 1970s and '80s women in print movement. While Parker and Kim have been rightly placed within African-American and Asian-American histories, respectively, and working-class and lesbian-feminist literary histories, their work is most fully understood within the context of U.S. Third World Feminism. Through close readings of poetic form and content in addition to engagement with current debates about intersectionality as a methodology, the article links Kim and Parker's works to central contributions of U.S. Third World Feminism such as intersectionality and power across and within difference that continue to influence feminist theory today.

Evaluation of objectivity, reliability and criterion validity of the key indicator method for manual handling operations (KIM-MHO), draft 2007.

PubMed

Klußmann, André; Gebhardt, Hansjürgen; Rieger, Monika; Liebers, Falk; Steinberg, Ulf

2012-01-01

Upper extremity musculoskeletal symptoms and disorders are common in the working population. The economic and social impact of such disorders is considerable. Long-time, dynamic repetitive exposure of the hand-arm system during manual handling operations (MHO) alone or in combination with static and postural effort are recognised as causes of musculoskeletal symptoms and disorders. The assessment of these manual work tasks is crucial to estimate health risks of exposed employees. For these work tasks, a new method for the assessment of the working conditions was developed and a validation study was performed. The results suggest satisfying criterion validity and moderate objectivity of the KIM-MHO draft 2007. The method was modified and evaluated again. It is planned to release a new version of KIM-MHO in spring 2012.

Vapor-liquid phase equilibria of water modelled by a Kim-Gordon potential

DOE Office of Scientific and Technical Information (OSTI.GOV)

Maerzke, K A; McGrath, M J; Kuo, I W

2009-03-16

Gibbs ensemble Monte Carlo simulations were carried out to investigate the properties of a frozen-electron-density (or Kim-Gordon, KG) model of water along the vapor-liquid coexistence curve. Because of its theoretical basis, such a KG model provides for seamless coupling to Kohn-Sham density functional theory for use in mixed quantum mechanics/molecular mechanics (QM/MM) implementations. The Gibbs ensemble simulations indicate rather limited transferability of such a simple KG model to other state points. Specifically, a KG model that was parameterized by Barker and Sprik to the properties of liquid water at 300 K, yields saturated vapor pressures and a critical temperature thatmore » are significantly under- and over-estimated, respectively.« less

North Korean Leadership Dynamics and Decision-making under Kim Jong-un: A First Year Assessment

DTIC Science & Technology

2013-09-01

regarding policy and its calculus regard- ing provocation versus engagement will be considered both for what they say about stability within the...briefing the policy when Ri pushed back, saying , "The policy is an ill-advised idea that denies the socialist principles that our previous supreme...leadership. Kim Jong-un then stood up and stripped Ri of his title and rank on the spot and had him arrested, saying , "I can- not work for revolution with

"Sundiata, Lion King of Mali." Adapted by Kim Hines, Featuring Griot Alhaji Papa Susso, Cue Sheet for Students.

ERIC Educational Resources Information Center

Freeman, Aakhu TuahNera

This performance guide is designed for teachers to use with students before and after a performance of "Sundiata: Lion King of Mali," adapted by Kim Hines and featuring Griot Alhaji Papa Susso. The guide, called a "Cuesheet," contains seven activity sheets for use in class, addressing: (1) Sundiata: Man & Myth (discusses…

Differences in immunolocalization of Kim-1, RPA-1, and RPA-2 in kidneys of gentamicin-, cisplatin-, and valproic acid-treated rats: potential role of iNOS and nitrotyrosine.

PubMed

Zhang, Jun; Goering, Peter L; Espandiari, Parvaneh; Shaw, Martin; Bonventre, Joseph V; Vaidya, Vishal S; Brown, Ronald P; Keenan, Joe; Kilty, Cormac G; Sadrieh, Nakissa; Hanig, Joseph P

2009-08-01

The present study compared the immunolocalization of Kim-1, renal papillary antigen (RPA)-1, and RPA-2 with that of inducible nitric oxide synthase (iNOS) and nitrotyrosine in kidneys of gentamicin sulfate (Gen)- and cisplatin (Cis)-treated rats. The specificity of acute kidney injury (AKI) biomarkers, iNOS, and nitrotyrosine was evaluated by dosing rats with valproic acid (VPA). Sprague-Dawley (SD) rats were injected subcutaneously (sc) with 100 mg/kg/day of Gen for six or fourteen days; a single intraperitoneal (ip) dose of 1, 3, or 6 mg/kg of Cis; or 650 mg/kg/day of VPA (ip) for four days. In Gen-treated rats, Kim-1 was expressed in the epithelial cells, mainly in the S1/S2 segments but less so in the S3 segment, and RPA-1 was increased in the epithelial cells of collecting ducts (CD) in the cortex. Spatial expression of iNOS or nitrotyrosine with Kim-1 or RPA-1 was detected. In Cis-treated rats, Kim-1 was expressed only in the S3 segment cells, and RPA-1 and RPA-2 were increased in the epithelial cells of medullary CD or medullary loop of Henle (LH), respectively. Spatial expression of iNOS or nitrotyrosine with RPA-1 or RPA-2 was also identified. These findings suggest that peroxynitrite formation may be involved in the pathogenesis of Gen and Cis nephrotoxicity and that Kim-1, RPA-1, and RPA-2 have the potential to serve as site-specific biomarkers for Gen or Cis AKI.

North Korean Leadership Dynamics and Decision-making under Kim Jong-un: A Second Year Assessment

DTIC Science & Technology

2014-03-01

engagement will be considered both for what they say about stability within the regime and for any insights that could inform the United States...briefing the policy when Ri pushed back, saying , "The policy is an ill-advised idea that denies the socialist principles that our previous supreme...leadership. Kim Jong-un then stood up and stripped Ri of his title and rank on the spot and had him arrested, saying , "I can- not work for revolution with

Urinary Biomarkers KIM-1 and NGAL for Detection of Chronic Kidney Disease of Uncertain Etiology (CKDu) among Agricultural Communities in Sri Lanka.

PubMed

De Silva, Pallagae Mangala C S; Mohammed Abdul, Khaja Shameem; Eakanayake, Eakanayake M D V; Jayasinghe, Sudheera Sammanthi; Jayasumana, Channa; Asanthi, Hewa Bandulage; Perera, Hettiarachigae S D; Chaminda, Gamage G Tushara; Chandana, Ediriweera P S; Siribaddana, Sisira H

2016-09-01

Chronic Kidney Disease of uncertain etiology (CKDu) is an emerging epidemic among farming communities in rural Sri Lanka. Victims do not exhibit common causative factors, however, histopathological studies revealed that CKDu is a tubulointerstitial disease. Urine albumin or albumin-creatinine ratio is still being used as a traditional diagnostic tool to identify CKDu, but accuracy and prevalence data generated are questionable. Urinary biomarkers have been used in similar nephropathy and are widely recognised for their sensitivity, specificity and accuracy in determining CKDu and early renal injury. However, these biomarkers have never been used in diagnosing CKDu in Sri Lanka. Male farmers (n = 1734) were recruited from 4 regions in Sri Lanka i.e. Matara and Nuwara Eliya (farming locations with no CKDu prevalence) and two CKDu emerging locations from Hambantota District in Southern Sri Lanka; Angunakolapelessa (EL1) and Bandagiriya (EL2). Albuminuria (ACR ≥ 30mg/g); serum creatinine based estimation of glomerular filtration rate (eGFR); creatinine normalized urinary kidney injury molecule (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) were measured. Fourteen new CKDu cases (18%) from EL1 and nine CKDu cases (9%) from EL2 were recognized for the first time from EL1, EL2 locations, which were previously considered as non-endemic of the disease and associated with persistent albuminuria (ACR ≥ 30mg/g Cr). No CKDu cases were identified in non-endemic study locations in Matara (CM) and Nuwara Eliya (CN). Analysis of urinary biomarkers showed urinary KIM-1 and NGAL were significantly higher in new CKDu cases in EL1 and EL2. However, we also reported significantly higher KIM-1 and NGAL in apparently healthy farmers in EL 1 and EL 2 with comparison to both control groups. These observations may indicate possible early renal damage in absence of persistent albuminuria and potential capabilities of urinary KIM-1 and NGAL in early detection of renal injury

Urinary Biomarkers KIM-1 and NGAL for Detection of Chronic Kidney Disease of Uncertain Etiology (CKDu) among Agricultural Communities in Sri Lanka

PubMed Central

Mohammed Abdul, Khaja Shameem; Eakanayake, Eakanayake M. D. V.; Jayasinghe, Sudheera Sammanthi; Jayasumana, Channa; Asanthi, Hewa Bandulage; Perera, Hettiarachigae S. D.; Chaminda, Gamage G. Tushara; Chandana, Ediriweera P. S.; Siribaddana, Sisira H.

2016-01-01

Chronic Kidney Disease of uncertain etiology (CKDu) is an emerging epidemic among farming communities in rural Sri Lanka. Victims do not exhibit common causative factors, however, histopathological studies revealed that CKDu is a tubulointerstitial disease. Urine albumin or albumin-creatinine ratio is still being used as a traditional diagnostic tool to identify CKDu, but accuracy and prevalence data generated are questionable. Urinary biomarkers have been used in similar nephropathy and are widely recognised for their sensitivity, specificity and accuracy in determining CKDu and early renal injury. However, these biomarkers have never been used in diagnosing CKDu in Sri Lanka. Male farmers (n = 1734) were recruited from 4 regions in Sri Lanka i.e. Matara and Nuwara Eliya (farming locations with no CKDu prevalence) and two CKDu emerging locations from Hambantota District in Southern Sri Lanka; Angunakolapelessa (EL1) and Bandagiriya (EL2). Albuminuria (ACR ≥ 30mg/g); serum creatinine based estimation of glomerular filtration rate (eGFR); creatinine normalized urinary kidney injury molecule (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) were measured. Fourteen new CKDu cases (18%) from EL1 and nine CKDu cases (9%) from EL2 were recognized for the first time from EL1, EL2 locations, which were previously considered as non-endemic of the disease and associated with persistent albuminuria (ACR ≥ 30mg/g Cr). No CKDu cases were identified in non-endemic study locations in Matara (CM) and Nuwara Eliya (CN). Analysis of urinary biomarkers showed urinary KIM-1 and NGAL were significantly higher in new CKDu cases in EL1 and EL2. However, we also reported significantly higher KIM-1 and NGAL in apparently healthy farmers in EL 1 and EL 2 with comparison to both control groups. These observations may indicate possible early renal damage in absence of persistent albuminuria and potential capabilities of urinary KIM-1 and NGAL in early detection of renal injury

First record of the spider genus Wolongia Zhu, Kim Song, 1997 from India with the description of a new species (Araneae, Tetragnathidae).

PubMed

Malamel, Jobi J; Nafin, Karunnappilli Shamsudheen; Sankaran, Pradeep M; Sebastian, Pothalil A

2018-04-09

Zhu et al. (1997) erected the tetragnathid genus Wolongia to accommodate Wolongia guoi Zhu, Kim Song, 1997 and Wolongia wangi Zhu, Kim Song, 1997 collected from the Sichuan and Shaanxi Provinces in China. In 2009, Ping et al. described Wolongia odontodes from the Gaoligong Mountains and remained with a nominal representation after the erection of the genus. This situation was somewhat rectified by Jin-long Wan Xian-jin Peng (2013) reporting seven new species from the Gaoligong Mountains (Yunnan Province, southwest China). The genus currently with ten nominal species; three are known only from females, while seven are from both sexes (World Spider Catalog 2017). During our survey in Pathiramanal Island we found an undescribed Wolongia species. This is one of the most diverse areas of the Kerala state of Southern India, situated in the Vembanad Lake, a Ramsar Convention (2013) site (wetland of international importance). In this paper, we describe this new species and provide the first report of Wolongia from India.

Validation of cooking times and temperatures for thermal inactivation of Yersinia pestis strains KIM5 and CDC-A1122 in irradiated ground beef.

PubMed

Porto-Fett, Anna C S; Juneja, Vijay K; Tamplin, Mark L; Luchansky, John B

2009-03-01

Irradiated ground beef samples (ca. 3-g portions with ca. 25% fat) inoculated with Yersina pestis strain KIM5 (ca. 6.7 log CFU/g) were heated in a circulating water bath stabilized at 48.9, 50, 52.5, 55, 57.5, or 60 degrees C (120, 122, 126.5, 131, 135.5, and 140 degrees F, respectively). Average D-values were 192.17, 34.38, 17.11, 3.87, 1.32, and 0.56 min, respectively, with a corresponding z-value of 4.67 degrees C (8.41 degrees F). In related experiments, irradiated ground beef patties (ca. 95 g per patty with ca. 25% fat) were inoculated with Y. pestis strains KIMS or CDC-A1122 (ca. 6.0 log CFU/g) and cooked on an open-flame gas grill or on a clam-shell type electric grill to internal target temperatures of 48.9, 60, and 71.1 degrees C (120, 140, and 160 degrees F, respectively). For patties cooked on the gas grill, strain KIM5 populations decreased from ca. 6.24 to 4.32, 3.51, and < or = 0.7 log CFU/g at 48.9, 60, and 71.1 degrees C, respectively, and strain CDC-A1122 populations decreased to 3.46 log CFU/g at 48.9 degrees C and to < or = 0.7 log CFU/g at both 60 and 71.1 degrees C. For patties cooked on the clam-shell grill, strain KIM5 populations decreased from ca. 5.96 to 2.53 log CFU/g at 48.9 degrees C and to < or = 0.7 log CFU/g at 60 or 71.1 degrees C, and strain CDC-A1122 populations decreased from ca. 5.98 to < or = 0.7 log CFU/g at all three cooking temperatures. These data confirm that cooking ground beef on an open-flame gas grill or on a clam-shell type electric grill to the temperatures and times recommended by the U.S. Department of Agriculture and the U.S. Food and Drug Administration Food Code, appreciably lessens the likelihood, severity, and/or magnitude of consumer illness if the ground beef were purposefully contaminated even with relatively high levels of Y. pestis.

Vapor-liquid phase equilibria of water modelled by a Kim-Gordon potential

DOE Office of Scientific and Technical Information (OSTI.GOV)

Maerzke, Katie A.; McGrath, M. J.; Kuo, I-F W.

2009-09-07

Gibbs ensemble Monte Carlo simulations were carried out to investigate the properties of a frozen-electron-density (or Kim-Gordon, KG) model of water along the vapor-liquid coexistence curve. Because of its theoretical basis, such a KG model provides for seamless coupling to Kohn-Sham density functional theory for use in mixed quantum mechanics/molecular mechanics (QM/MM) implementations. The Gibbs ensemble simulations indicate rather limited transferability of such a simple KG model to other state points. Specifically, a KG model that was parameterized by Barker and Sprik to the properties of liquid water at 300 K, yields saturated vapor pressures and a critical temperature thatmore » are significantly under- and overestimated, respectively. We present a comprehensive density functional theory study to asses the accuracy of two popular exchange correlation functionals on the structure and density of liquid water at ambient conditions This work was supported by the US Department of Energy Office of Basic Energy Science Chemical Sciences Program. Battelle operates Pacific Northwest National Laboratory for the US Department of Energy.« less

Association of urinary KIM-1, L-FABP, NAG and NGAL with incident end-stage renal disease and mortality in American Indians with type 2 diabetes mellitus.

PubMed

Fufaa, Gudeta D; Weil, E Jennifer; Nelson, Robert G; Hanson, Robert L; Bonventre, Joseph V; Sabbisetti, Venkata; Waikar, Sushrut S; Mifflin, Theodore E; Zhang, Xiaoming; Xie, Dawei; Hsu, Chi-Yuan; Feldman, Harold I; Coresh, Josef; Vasan, Ramachandran S; Kimmel, Paul L; Liu, Kathleen D

2015-01-01

Kidney injury molecule 1 (KIM-1), liver fatty acid-binding protein (L-FABP), N-acetyl-β-D-glucosaminidase (NAG) and neutrophil gelatinase-associated lipocalin (NGAL) are urinary biomarkers of renal tubular injury. We examined their association with incident end-stage renal disease (ESRD) and all-cause mortality in American Indians with type 2 diabetes. Biomarker concentrations were measured in baseline urine samples in 260 Pima Indians who were followed for a median of 14 years. HRs were reported per SD of creatinine (Cr)-normalised log-transformed KIM-1, NAG and NGAL, and for three categories of L-FABP. During follow-up, 74 participants developed ESRD and 101 died. Median concentrations of KIM-1/Cr, NAG/Cr and NGAL/Cr and the proportion of detectable L-FABP were highest in those with macroalbuminuria (p < 0.001 for KIM-1/Cr, NAG/Cr and L-FABP; p = 0.006 for NGAL/Cr). After multivariable adjustment, NGAL/Cr was positively associated with ESRD (HR 1.59, 95% CI 1.20, 2.11) and mortality (HR 1.39, 95% CI 1.06, 1.82); L-FABP/Cr was inversely associated with ESRD (HR [for highest vs lowest tertile] 0.40, 95% CI 0.19, 0.83). Addition of NGAL/Cr to models that included albuminuria and glomerular filtration rate increased the c-statistic for predicting ESRD from 0.828 to 0.833 (p = 0.001) and for death from 0.710 to 0.722 (p = 0.018). Addition of L-FABP/Cr increased the c-statistic for ESRD from 0.828 to 0.832 (p = 0.042). In Pima Indians with type 2 diabetes, urinary concentrations of NGAL and L-FABP are associated with important health outcomes, but they are unlikely to add to risk prediction with standard markers in a clinically meaningful way given the small increase in the c-statistic.

Viscous flux flow velocity and stress distribution in the Kim model of a long rectangular slab superconductor

NASA Astrophysics Data System (ADS)

Yang, Yong; Chai, Xueguang

2018-05-01

When a bulk superconductor endures the magnetization process, enormous mechanical stresses are imposed on the bulk, which often leads to cracking. In the present work, we aim to resolve the viscous flux flow velocity υ 0/w, i.e. υ 0 (because w is a constant) and the stress distribution in a long rectangular slab superconductor for the decreasing external magnetic field (B a ) after zero-field cooling (ZFC) and field cooling (FC) using the Kim model and viscous flux flow equation simultaneously. The viscous flux flow velocity υ 0/w and the magnetic field B* at which the body forces point away in all of the slab volumes during B a reduction, are determined by both B a and the decreasing rate (db a /dt) of the external magnetic field normalized by the full penetration field B p . In previous studies, υ 0/w obtained by the Bean model with viscous flux flow is only determined by db a /dt, and the field B* that is derived only from the Kim model is a positive constant when the maximum external magnetic field is chosen. This means that the findings in this paper have more physical contents than the previous results. The field B* < 0 can be kept for any value of B a when the rate db a /dt is greater than a certain value. There is an extreme value for any curve of maximum stress changing with decreasing field B a after ZFC if B* ≤ 0. The effect of db a /dt on the stress is significant in the cases of both ZFC and FC.

A Density Functional Approach to Polarizable Models: A Kim-Gordon-Response Density Interaction Potential for Molecular Simulations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Tabacchi, G; Hutter, J; Mundy, C

2005-04-07

A combined linear response--frozen electron density model has been implemented in a molecular dynamics scheme derived from an extended Lagrangian formalism. This approach is based on a partition of the electronic charge distribution into a frozen region described by Kim-Gordon theory, and a response contribution determined by the instaneous ionic configuration of the system. The method is free from empirical pair-potentials and the parameterization protocol involves only calculations on properly chosen subsystems. They apply this method to a series of alkali halides in different physical phases and are able to reproduce experimental structural and thermodynamic properties with an accuracy comparablemore » to Kohn-Sham density functional calculations.« less

Evaluation of a commercially available ELISA kit for quantifying imidacloprid residues in Erthrina sandwicensis leaves for management of the Erythrina gall wasp, Quadrastichus erythrinae Kim.

Treesearch

Joseph Fischer; Brian Strom; Sheri Smith

2009-01-01

The erythrina gall wasp (EGW), Quadrastichus erythrinae Kim 2004, was first detected in Hawaii in 2005 and has been infesting and killing Erythrina trees throughout the island chain since. It is believed EGW originated from Africa (Messing et al. 2009). Its host range appears to be limited to Erythrina; its...

L-Arginine attenuates the ethylene glycol induced urolithiasis in ininephrectomized hypertensive rats: role of KIM-1, NGAL, and NOs.

PubMed

Kandhare, Amit D; Patil, Mithun V K; Bodhankar, Subhash L

2015-05-01

Ethylene glycol (EG) exposure caused formation of calcium oxalate crystal that led to renal failure, which is associated with higher prevalence of hypertension. L-Arginine is known to have an antioxidant and nephro-protective potential. To evaluate the effect of L-arginine against EG-induced urolithiasis in uninephrectomized hypertensive rats. Uninephrectomized male Wistar rats (180-200 g) were used to induce urinary calculi through oral administration of EG (0.75%) in distilled water. Rats were treated with either distilled water (10 mg/kg, p.o.) or telmisartan (10 mg/kg, p.o.) or Cystone (500 mg/kg, p.o.) or L-arginine (250, 500, and 1000 mg/kg, p.o.) for 28 days. Various hemodynamic, biochemical, molecular, and histological parameters were assessed in kidney and heart. Rats treated with L-arginine (500 and 1000 mg/kg) significantly restored altered relative organ weight, urine output, urine density, urinary pH, and water intake. EG-induced alterations in electrocardiographic (QRS interval, HR, and ST height) and hemodynamic (SBP, DBP, MABP, and LVEDP) abnormalities were significantly restored by L-arginine (500 and 1000 mg/kg) treatment. It also significantly restored alteration in serum and urine biochemical parameters induced by EG. The elevated oxido-nitrosative stress was also significantly decreased by L-arginine (500 and 1000 mg/kg) treatment. It also significantly down-regulated EG-induced up-regulated renal KIM-1, NGAL, eNOS, and iNOs mRNA expressions. Histological aberrations induced in the renal and cardiac tissues were also ameliorated by l-arginine treatment. L-Arginine exerts its nephro- and cardio-protective potential in EG-induced urolithiasis in uninephrectomized hypertensive rats via modulation of KIM-1, NGAL, eNOS, and iNOs mRNA expression.

Ameliorative effect of naringin in acetaminophen-induced hepatic and renal toxicity in laboratory rats: role of FXR and KIM-1.

PubMed

Adil, Mohammad; Kandhare, Amit D; Ghosh, Pinaki; Venkata, Shivakumar; Raygude, Kiran S; Bodhankar, Subhash L

2016-07-01

Acetaminophen (APAP) is an analgesic and antipyretic agent commonly known agent to cause hepatic and renal toxicity at a higher dose. Naringin, a bioflavonoid possesses multiple pharmacological properties such as antioxidant, anti-inflammatory, analgesic and anti-hyperlipidemic activity. To evaluate the effect of naringin against the APAP-induced hepatic and renal toxicity. Male Wistar albino rats (180-220 g) were divided into various groups, and toxicity was induced by APAP (700 mg/kg, p.o., 14 days). Naringin (20, 40 and 80 mg/kg, p.o.) or Silymarin (25 mg/kg) was administered to rats 2 h before APAP oral administration. Various biochemical, molecular and histopathological parameter were accessed in hepatic and renal tissue. Naringin pretreatment significantly decreased (p < 0.05) serum creatinine, blood urea nitrogen, bilirubin, aspartate transaminase, alanine transaminase, lactate dehydrogenase, low-density lipoprotein, very low-density lipoprotein, cholesterol and triglycerides as compared with APAP control rats. Decreased level of serum albumin, uric acid, and high-density lipoprotein were also significantly restored (p < 0.05) by naringin pretreatment. It also significantly restores (p < 0.05) the altered level of superoxide dismutase, reduced glutathione, malondialdehyde and nitric oxide in hepatic and renal tissue. Moreover, altered mRNA expression of hepatic farnesoid X receptor and renal injury molecule-1 (KIM-1) were significantly restored (p < 0.05) by naringin treatment. Naringin treatment also reduced histological alteration induced by APAP in the liver and kidney. Naringin exerts its hepato- and nephroprotective effect via modulation of oxido-nitrosative stress, FXR and KIM-1 mRNA expression.

The cross-gender performances of Yam Kim-Fei, or the queer factor in postwar Hong Kong Cantonese opera/opera films.

PubMed

Tan, S K

2000-01-01

This essay is designed as a brief historical examination of the Cantonese female cross-dressing star Yam Kim-Fei, whose hundreds of films and opera performances in the '50s and '60s have made her one of the century's most celebrated transvestite artists. While her craft has often been relegated to studies of gender alone, I assert that the traditions of Chinese operatic transvestism she employs are not merely a relativist historical-artistic mode without political relevance but can be justifiably reclaimed for the purposes of queer interpretation and spectatorship-for indeed their original intent coincides very well with what we call "queer" today.

Naringin ameliorates sodium arsenite-induced renal and hepatic toxicity in rats: decisive role of KIM-1, Caspase-3, TGF-β, and TNF-α.

PubMed

Adil, Mohammad; Kandhare, Amit D; Visnagri, Asjad; Bodhankar, Subhash L

2015-01-01

Chronic exposure of a naturally occurring metal arsenic leads to renal and hepatic diseases. Naringin, a flavanone glycoside, possesses anti-inflammatory and anti-oxidant potential. The aim of this investigation was to evaluate the protective effect of naringin against arsenic-induced renal and hepatic toxicity in rats. Renal and hepatic toxicity was induced in rats by sodium arsenite (5 mg/kg, p.o.). Rats were treated orally with either vehicle or naringin (20, 40, and 80 mg/kg) or Coenzyme Q10 (10 mg/kg) for 28 days. Various biochemical, histological, and molecular biomarkers were assessed in kidney and liver. Treatment with naringin (40 and 80 mg/kg) significantly and dose-dependently restored (p < 0.01 and p < 0.001) altered levels of kidney (serum creatinine, urine creatinine, BUN, uric acid, and creatinine clearance) and liver function test (AST and ALT) induced by sodium arsenite. Elevated levels of oxido-nitrosative stress in renal and hepatic tissue was significantly and dose-dependently decreased (p < 0.01 and p < 0.001) by naringin (40 and 80 mg/kg) treatment. It significantly and dose-dependently down-regulated (p < 0.01 and p < 0.001) renal KIM-1, Caspase-3, TGF-β, and TNF-α mRNA expression. Histopathological alteration induced in kidney and liver by sodium arsenite was reduced by naringin (40 and 80 mg/kg) treatment. In conclusion, naringin treatment ameliorates arsenic-induced renal and hepatic damage in rats due its antioxidant and anti-inflammatory properties via down-regulation of elevated oxido-nitrosative stress, KIM-1, Caspase-3, TGF-β, and TNF-α levels.

Teacher Kim Cantrell from the Edwards Air Force Base Middle School, Edwards, Calif., participating in a live uplink at NASA Dryden as part of NASA's Explorer Schools program, asks the crew of the International Space Station a question

NASA Image and Video Library

2003-07-15

Teacher Kim Cantrell from the Edwards Air Force Base Middle School, Edwards, Calif., participating in a live uplink at NASA Dryden as part of NASA's Explorer Schools program, asks the crew of the International Space Station a question.

A misleading review of response bias: comment on McGrath, Mitchell, Kim, and Hough (2010).

PubMed

Rohling, Martin L; Larrabee, Glenn J; Greiffenstein, Manfred F; Ben-Porath, Yossef S; Lees-Haley, Paul; Green, Paul; Greve, Kevin W

2011-07-01

In the May 2010 issue of Psychological Bulletin, R. E. McGrath, M. Mitchell, B. H. Kim, and L. Hough published an article entitled "Evidence for Response Bias as a Source of Error Variance in Applied Assessment" (pp. 450-470). They argued that response bias indicators used in a variety of settings typically have insufficient data to support such use in everyday clinical practice. Furthermore, they claimed that despite 100 years of research into the use of response bias indicators, "a sufficient justification for [their] use… in applied settings remains elusive" (p. 450). We disagree with McGrath et al.'s conclusions. In fact, we assert that the relevant and voluminous literature that has addressed the issues of response bias substantiates validity of these indicators. In addition, we believe that response bias measures should be used in clinical and research settings on a regular basis. Finally, the empirical evidence for the use of response bias measures is strongest in clinical neuropsychology. We argue that McGrath et al.'s erroneous perspective on response bias measures is a result of 3 errors in their research methodology: (a) inclusion criteria for relevant studies that are too narrow; (b) errors in interpreting results of the empirical research they did include; (c) evidence of a confirmatory bias in selectively citing the literature, as evidence of moderation appears to have been overlooked. Finally, their acknowledging experts in the field who might have highlighted these errors prior to publication may have prevented critiques during the review process.

VizieR Online Data Catalog: Galaxy structural parameters from 3.6um images (Kim+, 2014)

NASA Astrophysics Data System (ADS)

Kim, T.; Gadotti, D. A.; Sheth, K.; Athanassoula, E.; Bosma, A.; Lee, M. G.; Madore, B. F.; Elmegreen, B.; Knapen, J. H.; Zaritsky, D.; Ho, L. C.; Comeron, S.; Holwerda, B.; Hinz, J. L.; Munoz-Mateos, J.-C.; Cisternas, M.; Erroz-Ferrer, S.; Buta, R.; Laurikainen, E.; Salo, H.; Laine, J.; Menendez-Delmestre, K.; Regan, M. W.; de Swardt, B.; Gil de Paz, A.; Seibert, M.; Mizusawa, T.

2016-03-01

We select our samples from the Spitzer Survey of Stellar Structure in Galaxies (S4G; Sheth et al. 2010, cat. J/PASP/122/1397). We chose galaxies that had already been processed by the first three S4G pipelines (Pipelines 1, 2, and 3; Sheth et al. 2010, cat. J/PASP/122/1397) at the moment of this study (2011 November). In brief, Pipeline processes images and provides science-ready images. Pipeline 2 prepares mask images (to exclude foreground and background objects) for further analysis, and Pipeline 3 derives surface brightness profiles and total magnitudes using IRAF ellipse fits. We excluded highly inclined (b/a<0.5), significantly disturbed, very faint, or irregular galaxies. Galaxies were also discarded if their images are unsuitable for decomposition due to contamination such as a bright foreground star or significant stray light from stars in the IRAC scattering zones. Then we chose barred galaxies from all Hubble types from S0 to Sdm using the numerical Hubble types from Hyperleda (Paturel et al. 2003, cat. VII/237, VII/238). The assessment of the presence of a bar was done visually by K. Sheth, T. Kim, and B. de Swardt. Later, we also confirmed the presence of a bar by checking the mid-infrared classification (Buta et al. 2010, cat. J/ApJS/190/147; Buta et al. 2015, cat. J/ApJS/217/32). A total of 144 barred galaxies were selected that satisfy our criteria, and we list our sample in Table1 with basic information. Table2 presents the measures of structural parameters for all galaxies in the sample obtained from the 2D model fit with BUDDA (BUlge/disk Decomposition Analysis, de Souza et al., 2004ApJS..153..411D; Gadotti, 2008MNRAS.384..420G) code. (2 data files).

Comment on Underwater Explosion (UWE) Analysis of the ROKS Cheonan Incident by S.G. Kim and Y. Kitterman

NASA Astrophysics Data System (ADS)

Kim, Kwang Sup

2013-03-01

The analysis of the seismic and infrasound data recorded at the time of the Cheonan incident led Kim and Gitterman (this journal, published on line August 2012) to conclude that a non-contact underwater explosion had sunk the ship. They also concluded that one of the mines deployed by the South Korean Navy many years ago in the area and then abandoned sank the ship. Their mine theory that is based on the explosive charge weights they calculated by means of two methods using the bubble period determined by their analysis, however, appears to be invalid. Although the incident had occurred in a shallow sea with a depth of less than 50m, the authors used the methods that are applicable only to free-field underwater explosions. The consideration of the influence on the bubble period of the nearby sea surface and bottom and the nearby ship's hull would double the calculated weights. In addition, the authors ignored several evidences that support the torpedo theory. One of them is aluminum-containing white powder found in large quantities at certain substrates in the retrieved Cheonan. However, the conclusion of the official investigation group that the torpedo was made in North Korea is based on a circumstantial evidence and is yet to be proven with other more direct evidences.

Analysis of the coexisting pathways for NO and N2O formation in Chernozem using the (15)N-tracer SimKIM-Advanced model.

PubMed

Stange, Claus Florian; Spott, Oliver; Russow, Rolf

2013-01-01

The nitrogen (N) cycle consists of a variety of microbial processes. These processes often occur simultaneously in soils, but respond differently to local environmental conditions due to process-specific biochemical restrictions (e.g. oxygen levels). Hence, soil nitrogen cycling (e.g. soil N gas production through nitrification and denitrification) is individually affected through these processes, resulting in the complex and highly dynamic behaviour of total soil N turnover. The development and application of methods that facilitate the quantification of individual contributions of coexisting processes is a fundamental prerequisite for (i) understanding the dynamics of soil N turnover and (ii) implementing these processes in ecosystem models. To explain the unexpected results of the triplet tracer experiment (TTE) of Russow et al. (Role of nitrite and nitric oxide in the processes of nitrification and denitrification in soil: results from (15)N tracer experiments. Soil Biol Biochem. 2009;41:785-795) the existing SimKIM model was extended to the SimKIM-Advanced model through the addition of three separate nitrite subpools associated with ammonia oxidation, oxidation of organic nitrogen (Norg), and denitrification, respectively. For the TTE, individual treatments with (15)N ammonium, (15)N nitrate, and (15)N nitrite were conducted under oxic, hypoxic, and anoxic conditions, respectively, to clarify the role of nitric oxide as a denitrification intermediate during N2O formation. Using a split nitrite pool, this analysis model explains the observed differences in the (15)N enrichments in nitric oxide (NO) and nitrous oxide (N2O) which occurred in dependence on different oxygen concentrations. The change from oxic over hypoxic to anoxic conditions only marginally increased the NO and N2O release rates (1.3-fold). The analysis using the model revealed that, under oxic and hypoxic conditions, Norg-based N2O production was the dominant pathway, contributing to 90 and 50�

Kim Magrini | NREL

Science.gov Websites

Developing char-based soil amendments Soil carbon and char analysis via molecular beam mass spectrometry depth profiling, Fourier transform infrared [FTIR]) Rapid soil carbon analysis using analytical DRIFTS, 13C NMR, and py-MBMS to Characterize the Effects of Soil Science Oxidation Assays on Soil Organic

Keeping Kim; How the Kim Conundrum Best Serves American Interests in the Asia Pacific

DTIC Science & Technology

2018-04-18

economically with the PRC, which has experienced exponential growth over the past twenty-five years while simultaneously administering a significant...looking to expand their influence in the region. This expansion is occurring via economics and territorial disputes in the region. Although many...One Road Initiative is a massive diplomatic and economic development to connect Asia and Europe with roads, railways, pipelines, and data cables

Translations on North Korea, Number 537

DTIC Science & Technology

1977-07-05

Kim Yong -chu, then director of the party’s agitprop department. In the second half of the 1960’s he was named director of the culture and...that he became widely known. At the 7th plenum of the Central Committee, Ch’oe Yong -kin and Kim II proposed Kim Chong-il as the successor to Kim Il...visit of the NCNA delegation were the following: Kim Yong -nam Kim Song-köl Kim Si-hak Kim Yong -sun Ch’ae Chun-pyong Chong

Seonah Kim, Ph.D. | NREL

Science.gov Websites

lignocellulosic biomass enzymes Design of new catalysts for vapor phase upgrading of biomass pyrolysis Enzymatic Engineering for Continuous Hydrocarbon Fuel Production (PI) Computational Pyrolysis Consortium Zeolite design Celluase enzyme structure-function relationships to design enhanced cellulose systems Catalyst

Kim Davis: A Mother's Dilemma.

ERIC Educational Resources Information Center

Hudecki, Michael S.

2000-01-01

Presents a discussion case in which parents must decide whether or not to enroll their sons in an experimental treatment program for muscular dystrophy. Identifies teaching objectives and discusses the key issues of the case--muscle structure and function, muscular dystrophy, scientists and money, scientific method and the FDA, and family health…

Southeast Asia Report. Peoples Republic of Kampuchea: Biographic Information on Officials

DTIC Science & Technology

1987-04-10

Jun 84). Chairman of Kompong Som Municipal People’s Revolutionary Committee; see KIM SANGKUM. Candidate in May 81 general elections. Secretary of...and Education Department Chief. Charge d’Affaires to Hanoi (Dec 85). 24 KHUON RAN KHVAN SAMNANG KIENG SAVUT KIM HAK ( KIM NET) KIM SAM-AN... KIM SANGKUM KIM SEAP KIM YIN KIT BUNNA, Ms KIT KIMHUON (KIT KROEUNVUTTHA) Ambassador to Hungary (Oct 80). Secretary of Phnom Penh Agriculture

A Study of China’s Possible Military Intervention in the Event of a Sudden Change in North Korea

DTIC Science & Technology

2011-06-10

Kim Jong - nam , Kim Jong -chul or Kim Jong -un as Kim‘s successor. Some have asserted that there might not be a third generation of Kim ...The power struggle between Kim Jong - nam (eldest son) who is residing in China and Kim Jong -un has been observed in many places over time. Kim 29... Jong - nam , who is known to be receiving Chinese support, revealed his opposition to a third generation of dynastic succession in

Urine Kidney Injury Molecule-1: A Potential Non-invasive Biomarker for Patients with Renal Cell Carcinoma

PubMed Central

Zhang, Ping L.; Mashni, Joseph W.; Sabbisetti, Venkata S.; Schworer, Charles M.; Wilson, George D.; Wolforth, Stacy C.; Kernen, Kenneth M.; Seifman, Brian D.; Amin, Mitual B.; Geddes, Timothy J.; Lin, Fan; Bonventre, Joseph V.; Hafron, Jason M.

2014-01-01

Objective To evaluate the use of urine KIM-1 as a biomarker for supporting a diagnosis of kidney cancers before operation. Methods A total of 19 patients were enrolled in the study based on preoperative imaging studies. Pre-operative and follow-up (1 month) uKIM-1 levels were measured and normalized with uCr levels and renal tumors were stained for KIM-1 using immunohistochemical techniques. Results The percentage of KIM-1 positive staining RCC cells ranged from 10 to 100% and the staining intensity ranged from 1+ to 3+. Based on the KIM-1 staining, 19 cases were divided into the KIM-1-negative staining group (n =7) and the KIM-1-positive group (n = 12). Serum creatinine (sCR) levels were significantly elevated after nephrectomy in both groups. In the KIM-1 negative group, uKIM-1/uCr remained at a similar level before (0.37 ± 0.1 ng/mg Cr) and after nephrectomy (0.32 ± 0.01 ng/mg Cr). However, in the KIM-1 positive group, elevated uKIM-1/uCr at 1.20 ± 0.31 ng/mg Cr was significantly reduced to 0.36± 0.1 ng/mg Cr, which was similar to the pre-operative uKIM-1/uCr (0.37 ± 0.1 ng/mg Cr) in the KIM-1 negative group. Conclusion Our study showed significant reduction in uKIM-1/uCr after nephrectomy, suggesting that urine KIM-1 may serve as a surrogate biomarker for kidney cancer and a non-invasive pre-operative measure to evaluate the malignant potential of renal masses. PMID:23979814

Korean Affairs Report

DTIC Science & Technology

1985-08-19

SOUTH KOREA POLITICS AND GOVERNMENT NKDP Post-Election Tasks, Problems Scrutinized (HANGUK ILBO, 17 Feb 85) • 63 67 Kim Tae-chung, Kim Yong -sam...National Day 122 Kim Il-song Sends Greetings 123 Kim Yong -nam Greets Maldives Counterpart 123 Kim Il-song Greets Peru President on National Day (KCNA, 27...including Kim Tae- yong , member of the Subcommittee for the Masses of the Sammin Struggle Committee of the Seoul National University [SNU], Ha Tong

DOE Office of Scientific and Technical Information (OSTI.GOV)

Keall, Paul J., E-mail: paul.keall@sydney.edu.au; Ng, Jin Aun; Juneja, Prabhjot

Purpose: Kilovoltage intrafraction monitoring (KIM) is a new real-time 3-dimensional image guidance method. Unlike previous real-time image guidance methods, KIM uses a standard linear accelerator without any additional equipment needed. The first prospective clinical trial of KIM is underway for prostate cancer radiation therapy. In this paper we report on the measured motion accuracy and precision using real-time KIM-guided gating. Methods and Materials: Imaging and motion information from the first 200 fractions from 6 patient prostate cancer radiation therapy volumetric modulated arc therapy treatments were analyzed. A 3-mm/5-second action threshold was used to trigger a gating event where the beammore » is paused and the couch position adjusted to realign the prostate to the treatment isocenter. To quantify the in vivo accuracy and precision, KIM was compared with simultaneously acquired kV/MV triangulation for 187 fractions. Results: KIM was successfully used in 197 of 200 fractions. Gating events occurred in 29 fractions (14.5%). In these 29 fractions, the percentage of beam-on time, the prostate displacement was >3 mm from the isocenter position, reduced from 73% without KIM to 24% with KIM-guided gating. Displacements >5 mm were reduced from 16% without KIM to 0% with KIM. The KIM accuracy was measured at <0.3 mm in all 3 dimensions. The KIM precision was <0.6 mm in all 3 dimensions. Conclusions: Clinical implementation of real-time KIM image guidance combined with gating for prostate cancer eliminates large prostate displacements during treatment delivery. Both in vivo KIM accuracy and precision are well below 1 mm.« less

Translations on North Korea. Number 616.

DTIC Science & Technology

1978-09-20

Chin-u, Kye Ung -tae, Kim -hwan, Kim Man-kum, Ho Tam, Chong Chun-ki and Kong Chin-tae. Attending the soiree were Comrade Han Tok-su, chairman of the...Committee which was held on 10 June under the leadership of Kim Il-song; listed ninth, after Kim Tu- yong and before No T’ae-sok (NODONG SINMUN 12 Jun...Province KWP Committee which was held on 10 June under the leadership of Kim Il-song; listed seventh, after Kang Song-san and before Kim Tu- yong

The Relationship Between U.S. Military Spending and the Cohesion of the Rok-U.S. Alliance

DTIC Science & Technology

2016-12-01

1992) .......................26 6. The Kim Young-Sam Administration (1992–1997) ..................27 7. The Kim Dae- Jung Administration (1998–2002...Administration ........................................41 7. The Kim Dae- Jung Administration ............................................42 8. The Roh Moo...50 7. The Kim Dae- Jung Administration ............................................51 8. The Roh Moo-Hyun Administration

Korean Affairs Report

DTIC Science & Technology

1986-03-26

with the "outrageous" measures recently taken by the police to block its headquarters, Floor leader Kim Tong- yong of the party said that he expects the... Kims on the party as a precondition, is too wide. In the wake of his recent meetings with Kim Yong -sam, Yi Min-u, and Kim Sang- hyon, Cho is...Initial police investigation showed that Yi was hit by a 50cm-long wooden bar carried by Yim Yong -chol, 23, a junior. Police apprehended Yim, Miss Kim

A Bioinformatics Approach Identifies Signal Transducer and Activator of Transcription-3 and Checkpoint Kinase 1 as Upstream Regulators of Kidney Injury Molecule-1 after Kidney Injury

PubMed Central

Ajay, Amrendra Kumar; Kim, Tae-Min; Ramirez-Gonzalez, Victoria; Park, Peter J.; Frank, David A.

2014-01-01

Kidney injury molecule-1 (KIM-1)/T cell Ig and mucin domain-containing protein-1 (TIM-1) is upregulated more than other proteins after AKI, and it is highly expressed in renal damage of various etiologies. In this capacity, KIM-1/TIM-1 acts as a phosphatidylserine receptor on the surface of injured proximal tubular epithelial cells, mediating phagocytosis of apoptotic cells, and it may also act as a costimulatory molecule for immune cells. Despite recognition of KIM-1 as an important therapeutic target for kidney disease, the regulators of KIM-1 transcription in the kidney remain unknown. Using a bioinformatics approach, we identified upstream regulators of KIM-1 after AKI. In response to tubular injury in rat and human kidneys or oxidant stress in human proximal tubular epithelial cells (HPTECs), KIM-1 expression increased significantly in a manner that corresponded temporally and regionally with increased phosphorylation of checkpoint kinase 1 (Chk1) and STAT3. Both ischemic and oxidant stress resulted in a dramatic increase in reactive oxygen species that phosphorylated and activated Chk1, which subsequently bound to STAT3, phosphorylating it at S727. Furthermore, STAT3 bound to the KIM-1 promoter after ischemic and oxidant stress, and pharmacological or genetic induction of STAT3 in HPTECs increased KIM-1 mRNA and protein levels. Conversely, inhibition of STAT3 using siRNAs or dominant negative mutants reduced KIM-1 expression in a kidney cancer cell line (769-P) that expresses high basal levels of KIM-1. These observations highlight Chk1 and STAT3 as critical upstream regulators of KIM-1 expression after AKI and may suggest novel approaches for therapeutic intervention. PMID:24158981

Chronic epithelial kidney injury molecule-1 expression causes murine kidney fibrosis.

PubMed

Humphreys, Benjamin D; Xu, Fengfeng; Sabbisetti, Venkata; Grgic, Ivica; Movahedi Naini, Said; Wang, Ningning; Chen, Guochun; Xiao, Sheng; Patel, Dhruti; Henderson, Joel M; Ichimura, Takaharu; Mou, Shan; Soeung, Savuth; McMahon, Andrew P; Kuchroo, Vijay K; Bonventre, Joseph V

2013-09-01

Acute kidney injury predisposes patients to the development of both chronic kidney disease and end-stage renal failure, but the molecular details underlying this important clinical association remain obscure. We report that kidney injury molecule-1 (KIM-1), an epithelial phosphatidylserine receptor expressed transiently after acute injury and chronically in fibrotic renal disease, promotes kidney fibrosis. Conditional expression of KIM-1 in renal epithelial cells (Kim1(RECtg)) in the absence of an injury stimulus resulted in focal epithelial vacuolization at birth, but otherwise normal tubule histology and kidney function. By 4 weeks of age, Kim1(RECtg) mice developed spontaneous and progressive interstitial kidney inflammation with fibrosis, leading to renal failure with anemia, proteinuria, hyperphosphatemia, hypertension, cardiac hypertrophy, and death, analogous to progressive kidney disease in humans. Kim1(RECtg) kidneys had elevated expression of proinflammatory monocyte chemotactic protein-1 (MCP-1) at early time points. Heterologous expression of KIM-1 in an immortalized proximal tubule cell line triggered MCP-1 secretion and increased MCP-1-dependent macrophage chemotaxis. In mice expressing a mutant, truncated KIM-1 polypeptide, experimental kidney fibrosis was ameliorated with reduced levels of MCP-1, consistent with a profibrotic role for native KIM-1. Thus, sustained KIM-1 expression promotes kidney fibrosis and provides a link between acute and recurrent injury with progressive chronic kidney disease.

Structural Basis of Substrate Recognition by Hematopoietic Tyrosine Phosphatase (HePTP)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Critton, D.; Tortajada, A; Stetson, G

2008-01-01

Hematopoietic tyrosine phosphatase (HePTP) is one of three members of the kinase interaction motif (KIM) phosphatase family which also includes STEP and PCPTP1. The KIM-PTPs are characterized by a 15 residue sequence, the KIM, which confers specific high-affinity binding to their only known substrates, the MAP kinases Erk and p38, an interaction which is critical for their ability to regulate processes such as T cell differentiation (HePTP) and neuronal signaling (STEP). The KIM-PTPs are also characterized by a unique set of residues in their PTP substrate binding loops, where 4 of the 13 residues are differentially conserved among the KIM-PTPsmore » as compared to more than 30 other class I PTPs. One of these residues, T106 in HePTP, is either an aspartate or asparagine in nearly every other PTP. Using multiple techniques, we investigate the role of these KIM-PTP specific residues in order to elucidate the molecular basis of substrate recognition by HePTP. First, we used NMR spectroscopy to show that Erk2-derived peptides interact specifically with HePTP at the active site. Next, to reveal the molecular details of this interaction, we solved the high-resolution three-dimensional structures of two distinct HePTP-Erk2 peptide complexes. Strikingly, we were only able to obtain crystals of these transient complexes using a KIM-PTP specific substrate-trapping mutant, in which the KIM-PTP specific residue T106 was mutated to an aspartic acid (T106D). The introduced aspartate side chain facilitates the coordination of the bound peptides, thereby stabilizing the active dephosphorylation complex. These structures establish the essential role of HePTP T106 in restricting HePTP specificity to only those substrates which are able to interact with KIM-PTPs via the KIM (e.g., Erk2, p38). Finally, we describe how this interaction of the KIM is sufficient for overcoming the otherwise weak interaction at the active site of KIM-PTPs.« less

Korean Affairs Report

DTIC Science & Technology

1986-11-19

Currently, the Korean opposition party leader most publicized in the U.S. media is Kim Tae -chung. His exile in Washington brought him fame as an...opposition party leader. Kim Tae -chung has appeared on the popular ABC current events program "Nightline," and he is frequently featured in newspapers...opposition party politicians. Kim Tae -chung, last May, wrote an article for THE WASHINGTON POST entitled, "What We Want." Mr Kim in this article

Korean Affairs Report, No. 315.

DTIC Science & Technology

1983-10-24

assuming the connection with Kim Yong -sam forces, reacted with an unexpectedly resolute stance, aiming its resolute response toward the Kim Yong -sam... Kim Yong -sam, former president of the now-defunct New Democratic Party, to a 10-day detention yesterday. Chon Hong-ki, 31, a member of the Minju...Democratic) Alpine Club, had stood before a summary court on 28 June for having spread printed material on the hunger strike of Kim Yong -sam. He was

Korean Affairs Report

DTIC Science & Technology

1986-03-31

Weinberger to open negotiations over the issue. North Korean Foreign Minister Kim Yong -nam expressed his willingness to comply with the U.S...dummy? The ruling party’s proposal in itself certainly is a change, but it is not reasonable. After a few consultations with Kim Tae-chung, Kim Yong -sam...Hungsadan Hall, making a. human tide which paralyzed traffic. As the crowd was growing out of their control, Yi Min-u and Kim Yong -sam stopped to

JPRS Report, East Asia, Korea: Kulloja, No. 12, December 1987.

DTIC Science & Technology

1988-12-29

Korean No 12, Dec 87 pp 56-59 [Article by Kim Se- yong ] [Text] One of the important problems arising in socialist economic construction is that of...Peace Zone in Asia and the Pacific SK200430 Pyongyang KULLOJA in Korean No 12, Dec 87 pp 85-89 [Special article by Kim Yong -sun] [Text] Today...Task in Indoctrinating the Youths 39-43 [Article not translated] 13 Brilliant Life of the Female Communist Revolutionary [ Kim Chong-suk, Kim Il

Korean Affairs Report No. 308.

DTIC Science & Technology

1983-09-14

Assemblyman Kim Yong -mok said: A tax evasion incident has finally turned into the fraud of the century. National Assemblyman Kim Chae- yong said...Pong Tu-hwan, Chairman of the National Assembly Foreign Affairs Committee, and Kim Yong -tae, the DJP spokesman, answering a reporter’s question on...debts of the Myongsong Group not been mentioned in the tax investigation report?" Representatives Kim Chae- yong , Han Kwang-ok and Hong Sa-tok from the

Translations on North Korea, Number 525.

DTIC Science & Technology

1977-04-28

Recounted ( Kim Tong-i; NODONG CH’ ONGNYOI, 28 Jan 77) 7 Struggle of ’Sea of Blood’ Guards in Speed Battle Described. (Han Yong -il; MIWJU CHOSON, 5...Praised as Invincible ( Kim Ik-hyon; MINJU CHOSON, Feb 77) 28 Foreign Attaches, Newsmen in DPRK Mark Kim Il-song Birthday (KCWA, 9 Apr 77) 3...Relay Racers Arrive in Pyongyang With Loyalty Letter (KCNA, 11 Apr 77) 35 Japanese Companies Offer Birthday Gifts to Kim Il-song (KCNA, 12

Translations on North Korea, Number 563

DTIC Science & Technology

1977-11-29

units are subordinate to the Unit to Which Comrade Kim ;e"J°\\S *elonf £nit leader Kim Yong - ung ) : The Triple Red Banner Unit to Which Comrade...No. 563 CONTENTS PAGE Development and Prosperity of Anju Described (Sonu Song-ok; MINJU CHOSON, 30 Aug 77) 1 Kim and Pak Receive Reply From GDR...CHOSON in Korean 30 Aug 77 p 4 [Article by Sonu Song-ok: "Anju Thriving With New Life"] [Text] The respected and beloved leader Comrade Kim Il

Control and Restructuring at the Syntax-Semantics Interface

ERIC Educational Resources Information Center

Grano, Thomas Angelo

2012-01-01

Landau (2000) distinguishes between P(artial) C(ontrol) and E(xhaustive) C(ontrol): PC predicates like hope admit a subset relation between controller and controllee (e.g., "Kim hoped to gather at noon." [controllee = Kim and contextually salient others]); EC predicates like "try" do not (*"Kim tried to gather at…

Quality assurance for the clinical implementation of kilovoltage intrafraction monitoring for prostate cancer VMAT

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ng, J. A.; Booth, J. T.; O’Brien, R. T.

2014-11-01

Purpose: Kilovoltage intrafraction monitoring (KIM) is a real-time 3D tumor monitoring system for cancer radiotherapy. KIM uses the commonly available gantry-mounted x-ray imager as input, making this method potentially more widely available than dedicated real-time 3D tumor monitoring systems. KIM is being piloted in a clinical trial for prostate cancer patients treated with VMAT (NCT01742403). The purpose of this work was to develop clinical process and quality assurance (QA) practices for the clinical implementation of KIM. Methods: Informed by and adapting existing guideline documents from other real-time monitoring systems, KIM-specific QA practices were developed. The following five KIM-specific QA testsmore » were included: (1) static localization accuracy, (2) dynamic localization accuracy, (3) treatment interruption accuracy, (4) latency measurement, and (5) clinical conditions accuracy. Tests (1)–(4) were performed using KIM to measure static and representative patient-derived prostate motion trajectories using a 3D programmable motion stage supporting an anthropomorphic phantom with implanted gold markers to represent the clinical treatment scenario. The threshold for system tolerable latency is <1 s. The tolerances for all other tests are that both the mean and standard deviation of the difference between the programmed trajectory and the measured data are <1 mm. The (5) clinical conditions accuracy test compared the KIM measured positions with those measured by kV/megavoltage (MV) triangulation from five treatment fractions acquired in a previous pilot study. Results: For the (1) static localization, (2) dynamic localization, and (3) treatment interruption accuracy tests, the mean and standard deviation of the difference are <1.0 mm. (4) The measured latency is 350 ms. (5) For the tests with previously acquired patient data, the mean and standard deviation of the difference between KIM and kV/MV triangulation are <1.0 mm. Conclusions: Clinical

Kilovoltage Intrafraction Monitoring for Prostate Intensity Modulated Arc Therapy: First Clinical Results

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ng, Jin Aun; Institute of Medical Physics, School of Physics, University of Sydney, New South Wales; Booth, Jeremy T.

2012-12-01

Purpose: Most linear accelerators purchased today are equipped with a gantry-mounted kilovoltage X-ray imager which is typically used for patient imaging prior to therapy. A novel application of the X-ray system is kilovoltage intrafraction monitoring (KIM), in which the 3-dimensional (3D) tumor position is determined during treatment. In this paper, we report on the first use of KIM in a prospective clinical study of prostate cancer patients undergoing intensity modulated arc therapy (IMAT). Methods and Materials: Ten prostate cancer patients with implanted fiducial markers undergoing conventionally fractionated IMAT (RapidArc) were enrolled in an ethics-approved study of KIM. KIM involves acquiringmore » kV images as the gantry rotates around the patient during treatment. Post-treatment, markers in these images were segmented to obtain 2D positions. From the 2D positions, a maximum likelihood estimation of a probability density function was used to obtain 3D prostate trajectories. The trajectories were analyzed to determine the motion type and the percentage of time the prostate was displaced {>=}3, 5, 7, and 10 mm. Independent verification of KIM positional accuracy was performed using kV/MV triangulation. Results: KIM was performed for 268 fractions. Various prostate trajectories were observed (ie, continuous target drift, transient excursion, stable target position, persistent excursion, high-frequency excursions, and erratic behavior). For all patients, 3D displacements of {>=}3, 5, 7, and 10 mm were observed 5.6%, 2.2%, 0.7% and 0.4% of the time, respectively. The average systematic accuracy of KIM was measured at 0.46 mm. Conclusions: KIM for prostate IMAT was successfully implemented clinically for the first time. Key advantages of this method are (1) submillimeter accuracy, (2) widespread applicability, and (3) a low barrier to clinical implementation. A disadvantage is that KIM delivers additional imaging dose to the patient.« less

Effect of continuous renal replacement therapy on kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin in patients with septic acute kidney injury

PubMed Central

Shao, Yiming; Fan, Yinqiang; Xie, Yuliu; Yin, Lu; Zhang, Yuanli; Deng, Liehua; Sun, Xiaocong; Shao, Xin; Tan, Xinzhang; He, Junbing; Zhao, Shiman

2017-01-01

Kidney injury molecule-1 (Kim-1) and neutrophil gelatinase-associated lipocalin (NGAL) have been investigated as biomarkers for acute kidney injury (AKI). However, they are seldom investigated in patients with septic AKI treated with continuous renal replacement therapy (CRRT). The aim of the present study was to investigate the therapeutic effectiveness and possible mechanisms of CRRT in septic AKI by observing the changes in Kim-1 and NGAL levels. A group of 38 patients with septic AKI was randomly divided into the conventional drug treatment group (group A) and the CRRT group (group B). All patients were treated with standard antisepsis agents, and group B was additionally submitted to CRRT for 24 h. The levels of Kim-1 and NGAL in serum, urine and the ultrafiltrate of CRRT were measured prior to and at 12, 24, and 48 h after treatment. In group A, urinary Kim-1 (uKim-1) levels at 12, 24 and 48 h were lower than prior to treatment (P<0.05), whereas urinary NGAL (uNGAL) showed no difference among the various time points (P>0.05). In group B, uKim-1 was decreased at 24 and 48 h compared with before treatment (all P<0.05), whereas uNGAL was decreased at 48 h (P<0.05). Serum Kim-1 did not change with time in groups A and B (P>0.05), whereas serum NGAL was increased after treatment in group A (P<0.05) but did not change in group B (P>0.05). Kim-1 and NGAL were not detected in the ultrafiltrate of CRRT. uKim-1 and uNGAL decreased significantly after CRRT, and therefore may be used to reflect the change of renal function during CRRT and to evaluate the therapeutic effectiveness of the method. PMID:28588686

Producing a Documentary in the Third Grade: Reaching All Students through Movie Making

ERIC Educational Resources Information Center

Fehn, Bruce; Heckart, Kimberly

2013-01-01

This article details the work of third grade teacher, co-author Kim Heckart, as she engaged her students in making historical documentaries: a project that succeeded in reaching all of her third-grade students. For the last five years, Kim has required students to make historical documentaries. As her students produced these works, Kim conversed…

Boron Nitride Substrates for High Mobility Chemical Vapor Deposited Graphene

DTIC Science & Technology

2011-06-13

Hone, H. L. Stormer , and P. Kim, Phys. Rev. Lett. 101, 096802 2008. 5K. I. Bolotin, K. J. Sikes, Z. Jiang, M. Klima, G. Fudenberg, J. Hone, P. Kim, and...H. L. Stormer , Solid State Commun. 146, 351 2008. 6S. Berciaud, S. Ryu, L. E. Brus, and T. F. Heinz, Nano Lett. 9, 346 2009. 7S. Bae, H. Kim, Y

Electrical Control of Silicon Photonic Crystal Cavity by Graphene

DTIC Science & Technology

2012-01-01

Henriksen, E. A.; Jiang, Z.; Hao, Z.; Martin, M. C.; Kim, P.; Stormer , H. L.; Basov, D. N. Nat. Phys. 2008, 4 (7), 532−535. (4) Liu, M.; Yin, X...Zhang, Y.; Tan, Y.-W.; Stormer , H. L.; Kim, P. Nature 2005, 438 (7065), 201−204. (21) Cho, J. H.; Lee, J.; Xia, Y.; Kim, B.; He, Y.; Renn, M. J

Targeting Murine Mesenchymal Stem Cells to Kidney Injury Molecule-1 Improves Their Therapeutic Efficacy in Chronic Ischemic Kidney Injury.

PubMed

Zou, Xiangyu; Jiang, Kai; Puranik, Amrutesh S; Jordan, Kyra L; Tang, Hui; Zhu, Xiangyang; Lerman, Lilach O

2018-05-01

Mesenchymal stem cells (MSC) have been experimentally used for kidney repair, but modest retention limits their efficacy. Cell-surface coating allows modulating MSC homing and interaction with target cells. We coated mouse adipose tissue-derived MSC with antibodies directed against kidney injury molecule-1 (ab-KIM1), which is upregulated in injured kidneys, and tested the hypothesis that this would enhance their therapeutic effects in ischemic kidney injury. Untreated MSC, ab-KIM1-coated MSC (KIM-MSC), or vehicle, were injected systemically into the carotid artery of 2-kidneys, 1-clip mice 2 weeks after surgery. MSC retention in different organs was explored 24 hours, 48 hours, or 2 weeks after injection. Renal volume, perfusion, and oxygenation were studied 2 weeks after injection using magnetic resonance imaging in vivo, and renal inflammation, apoptosis, capillary density, and fibrosis ex vivo. The ab-KIM1 coating had little effect on MSC viability or proliferation. The stenotic kidney showed upregulated KIM1 expression, selective homing, and greater retention of KIM-MSC compared to untreated MSC and compared to other organs. KIM-MSC-injected mice improved renal perfusion and capillary density, and attenuated oxidative damage, apoptosis, and fibrosis compared to mice treated with vehicle or with native MSC. In conclusion, MSC coating with ab-KIM1 increased their retention in the ischemic kidney and enhanced their therapeutic efficacy. This novel method may be useful to selectively target injured kidneys, and supports further development of strategies to enhance cell-based treatment of ischemic kidney injury. Stem Cells Translational Medicine 2018;7:394-403. © 2018 The Authors Stem Cells Translational Medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press.

Reducing Long-Term Costs While Preserving a Robust Strategic Airlift Fleet: Options for the Current Fleet and Next-Generation Aircraft

DTIC Science & Technology

2013-01-01

Ghashghai, Jeff Hagen, Thomas Hamilton, Gregory G. Hildebrandt , Yool Kim, Robert S. Leonard, Rosalind Lewis, Elvira N. Loredo, Daniel M. Norton, David T...Joan Cornuet, Mel Eisman, Chris Fitzmartin, Jean R. Gebman, Elham Ghashghai, Jeff Hagen, Thomas Hamilton, Gregory G. Hildebrandt , Yool Kim, Robert...Hagen, Thomas Hamilton, Gregory G. Hildebrandt , Yool Kim, Robert S. Leonard, Rosa- lind Lewis, Elvira N. Loredo, Daniel M. Norton, David T. Orletsky

Korean Affairs Report

DTIC Science & Technology

1985-04-22

DPRK-Romanian Relations (KCNA, various dates) 147 Kang Song-san Greets Romanian Counterpart 147 Kim Yong -nam Greets Romanian Counterpart 147...Independence Marked (KCNA, 3, 4 Apr 85) . 152 Papers Observe Anniversary 152 Greetings Sent 152 Independence Day Rally 153 Kim Yong -nam Message 153...them. In their speeches at the meeting Kim Chang- yong , vice-chairman of the Central Committee of the League of Socialist Working Youth, students of

Preface: Recent Developments in Taxonomy and Biodiversity of Symbiotic Copepoda (Crustacea)-A Volume in Celebration of the Career of Prof. Il-Hoi Kim.

PubMed

Huys, Rony

2016-10-11

Symbiosis is one of the most successful modes of life displayed by aquatic organisms, as measured by the number of times it evolved and how many symbiotic species are presently in existence. Among the Crustacea copepods utilize an extraordinary range of hosts, occurring on virtually every phylum of marine macroinvertebrates and, jointly with the monogeneans, are the most speciose group of metazoan ectoparasites of marine fishes (Rhode 2005). Several species have a major impact on global finfish and shellfish aquaculture, causing significant effects on farm production, economic viability and sustainability (Shinn et al. 2015). Parasitism by copepods on other metazoans has evolved independently numerous times in the evolutionary history of animal life on Earth and has led to an exceptional diversity in morphologies, physiologies, life-strategies and habitat preferences of its members. Reflecting the diversity of hosts, copepods show an amazing variety of adaptations which secure infection of and survival on the hosts. Since the first descriptions of parasitic copepods occurring on fish by Linnaeus (1758) and the first report of a copepod utilizing an invertebrate host by Say (1818) (Clausidium caudatum (Say, 1818)) the number of described symbiotic copepods has seen a steady increase over a 200-yr period, culminating in a total of 5,306 valid species recognized today. About 38% of all described copepod species utilize either vertebrate (2,450 spp.) or invertebrate hosts (2,856 spp.), however, many host groups have not been thoroughly examined, and for this reason even approximate estimates of true species numbers are futile. Plotting the proposal of new species by decade (Fig. 1) shows a sharp rise since 1950 with 67% of the species having been described in the preceding 65 years. This period of exceptionally rapid progress can be attributed to a number of highly prolific investigators such as Arthur Humes, Il-Hoi Kim, Ju-shey Ho and Jan Stock who, single-handedly or

Armed Forces and National Development in Korea

DTIC Science & Technology

1988-12-01

2698 Naval Postgraduate School Monterey, CA 93943 7. Ha, Tae Hwan SMC 2588 Naval Postgraduate School Monterey, CA 93943 8. Kim , Dong Hui SMC 2610 Naval...an agreement between the Provisional Government leader Kim Ku and Chiang Kai-Shek. Many of these Korean officers, mostly the Japanese-trained, played...when the military took over the corrupt and inefficient government [Ref. 6:p. 36]. Kim said that the military assumption of power in 1961 was

Two Dilemmas and Vicious Cycle of Confrontation on the Continuity of the Division of the Korean Peninsula

DTIC Science & Technology

2011-12-01

Secondly, the Kim Jong -Il regime’s concerns over the regime survival became a primary explanation of its behavior and policies. Behind these concerns...articles argue the Kim Jong -Il’s health and the succession issue are important variables of North Korean behavior today.19 This section attempts to...19 Jinwook Choi, “Why is North Korea so Aggressive? Kim Jong -Il’s Illness and North Korea’s Changing Governing Style,” Policy

Korean Affairs Report.

DTIC Science & Technology

1987-02-12

TRADE Government Revises Foreign Capital Investment Policy ( Kim Yong -hun; PUSAN SANGGONG, Nov 86) 32 NORTH KOREA POLITICS AND GOVERNMENT NODONG...PUSAN SANGGONG in Korean Nov 86 pp 64-65 [Article by Kim Yong -hun, director of the International Technology Transfer Research Center of Korea...leader in his historic policy speech. At the soldiers’ rally in the unit to which Comrade Cha Myong-pok belongs, Kim Chang- yong , a KPA general

Melvin v. Kim's Restaurant, Inc. [13 July 1989].

PubMed

1989-01-01

In Oregon, after her dismissal by the defendant, the plaintiff, a waitress employed by the defendant, brought a suit charging discrimination on the basis of handicap. She claimed that she had been dismissed because the defendant regarded her pregnancy as a physical impairment. The court allowed the suit to proceed, ruling that discrimination on the basis of pregnancy could constitute handicap discrimination. On 8 June 1989 the United States Court of Appeals, Ninth Circuit, held that consideration of the petitioner's pregnancy in deciding whether her case should be heard in the juvenile court did not constitute sex discrimination in violation of equal protection rights (Toomey v. Clark, 876 F.2d 1433).

Young Kim, PhD | Division of Cancer Prevention

Cancer.gov

The Division of Cancer Prevention (DCP) conducts and supports research to determine a person's risk of cancer and to find ways to reduce the risk. This knowledge is critical to making progress against cancer because risk varies over the lifespan as genetic and epigenetic changes can transform healthy tissue into invasive cancer.

Korean Affairs Report, Number 274.

DTIC Science & Technology

1983-03-23

Magazine Notes Kim Chong-il Treatise (KCNA, 28 Feb 83) 145 Foreign Functions Celebrate Kim Chong-il Birthday (KCNA, 28 Feb 83) 146 Kim...later. As part of the means for securing peace be- tween the North and South, South Korea has long stressed the need for cross recognition of North... need for the United States to adopt a positive approach to ease the tension between the North and South, we should not overlook the possibility that

Translations on North Korea No. 514

DTIC Science & Technology

1977-03-11

Yong -sok, Kim Ch’i-ku, Chi Chae-ryong, 0...Ch’ongjin were the following: Yim Ch’un-ch’u comrade Pak Yong -sok functionary of the sector concerned Kim Ch’i-ku " Chi Chae- yong 0 Hyon-chu Pak...electric railroad on 22 January were the following: Yim Ch’un-ch’u comrade Pak Yong -sok functionary of the sector concerned Kim Ch’i-ku " Chi Chae- yong

Translations on North Korea, Number 515.

DTIC Science & Technology

1977-03-15

Traditions Urged ( Kim Chong- ung ; NODONG SINMUN, 3 Jan 77) 16 Economic Role of Local Power Organs Important (KCNA, 26 Feb 77) 20 Meeting Held in...Pyongyang NODONG SINMUN in Korean 3 Jan 77 p 3 [Article by Kim Chong- ung : "In Order to Step Up the Indoctrination in the Revolutionary Traditions and to...the pending problems. The workers, including Comrade Kim Yong -nam, a work team leader, fully displayed the revolutionary spirit of self-reliance and

Lactobacillus allii sp. nov. isolated from scallion kimchi.

PubMed

Jung, Min Young; Lee, Se Hee; Lee, Moeun; Song, Jung Hee; Chang, Ji Yoon

2017-12-01

A novel strain of lactic acid bacteria, WiKim39 T , was isolated from a scallion kimchi sample consisting of fermented chili peppers and vegetables. The isolate was a Gram-positive, rod-shaped, non-motile, catalase-negative and facultatively anaerobic lactic acid bacterium. Phylogenetic analysis of the 16S rRNA gene sequence showed that strain WiKim39 T belonged to the genus Lactobacillus, and shared 97.1-98.2 % pair-wise sequence similarities with related type strains, Lactobacillus nodensis, Lactobacillus insicii, Lactobacillus versmoldensis, Lactobacillus tucceti and Lactobacillus furfuricola. The G+C content of the strain based on its genome sequence was 35.3 mol%. The ANI values between WiKim39 T and the closest relatives were lower than 80 %. Based on the phenotypic, biochemical, and phylogenetic analyses, strain WiKim39 T represents a novel species of the genus Lactobacillus, for which the name Lactobacillus allii sp. nov. is proposed. The type strain is WiKim39 T (=KCTC 21077 T =JCM 31938 T ).

Lactobacillus allii sp. nov. isolated from scallion kimchi

PubMed Central

Jung, Min Young; Lee, Se Hee; Lee, Moeun; Song, Jung Hee; Chang, Ji Yoon

2017-01-01

A novel strain of lactic acid bacteria, WiKim39T, was isolated from a scallion kimchi sample consisting of fermented chili peppers and vegetables. The isolate was a Gram-positive, rod-shaped, non-motile, catalase-negative and facultatively anaerobic lactic acid bacterium. Phylogenetic analysis of the 16S rRNA gene sequence showed that strain WiKim39T belonged to the genus Lactobacillus, and shared 97.1–98.2 % pair-wise sequence similarities with related type strains, Lactobacillus nodensis, Lactobacillus insicii, Lactobacillus versmoldensis, Lactobacillus tucceti and Lactobacillus furfuricola. The G+C content of the strain based on its genome sequence was 35.3 mol%. The ANI values between WiKim39T and the closest relatives were lower than 80 %. Based on the phenotypic, biochemical, and phylogenetic analyses, strain WiKim39T represents a novel species of the genus Lactobacillus, for which the name Lactobacillus allii sp. nov. is proposed. The type strain is WiKim39T (=KCTC 21077T=JCM 31938T). PMID:29043955

Kidney Injury Molecule Levels in Type 2 Diabetes Mellitus.

PubMed

Aslan, Ozgur; Demir, Metin; Koseoglu, Mehmet

2016-11-01

This study was designed to determine the diagnostic role of urinary kidney injury molecule (KIM)-1 levels in renal damage in patients with type 2 diabetes mellitus according to the urinary albumin/creatinine ratio. Patients with type 2 diabetes mellitus admitted to different polyclinics in our hospital enrolled in the study and were subdivided into three groups according to albumin/creatinine ratio - normalbuminuric (n: 20); microalbuminuric (n: 20); albuminuric (n: 18) - and compared with the control group. Urine albumin was analyzed using the immunoturbidimetric method (Architect C16000, Abbott Diagnostics). uKIM-1 was determined using a commercially available enzyme-linked immunosorbent assay test kit (USCN Life Science, Hankou, Wuhan, China). One-sample Kolmogorov-Smirnov test, Spearman correlation and Kruskal-Wallis non-parametric tests were performed. Post hoc comparisons were made using Bonferroni-corrected Mann-Whitney U tests. The differences between the controls and normalbuminuric, microalbuminuric and albuminuric groups were highly significant for KIM-1. Positive correlation was found between KIM-1 and urine microalbumin-urine microalbumin/creatinine (r = 0.479 P < 0.001; r = 0. 400, P < 0.001; respectively). In our study, KIM-1 levels were significantly different suggesting that urinary KIM-1 levels may be an early marker in patients with diabetic nephropathy. J. Clin. Lab. Anal. 00:1-6, 2016. © 2016 Wiley Periodicals, Inc.

Urinary biomarkers of acute kidney injury in deceased organ donors--kidney injury molecule-1 as an adjunct to predicting outcome.

PubMed

Field, Melanie; Dronavalli, Vamsi; Mistry, Punam; Drayson, Mark; Ready, Andrew; Cobbold, Mark; Inston, Nicholas

2014-07-01

Deceased kidney donors are increasingly "marginal," and many have risk factors for acute kidney injury (AKI) that may impact on subsequent renal transplant outcome. Despite this, determining the presence of AKI at the time of deceased organ donation remains difficult. Urine samples from 182 brainstem dead multi-organ donors (all of whom donated hearts that were transplanted) were analyzed for a Luminex(™) panel of biomarkers linked with AKI. This included KIM-1, NGAL, IFN-γ, TNF-α, cystatin C, Fractalkine and vascular endothelial growth factor. Levels were correlated to early renal transplant outcomes, most specifically delayed graft function. Donor urinary KIM-1 levels were significantly higher in donors whose kidneys displayed aberrant early function (p = 0.011). Fractalkine levels showed a trend toward elevation in such donors but uncorrected this did not attain significance. No correlation occurred with the remaining biomarkers. KIM-1 appears to show promise as a marker for AKI in deceased cardiac organ donors. The availability of a lateral flow device (Renastick(™) ) for KIM-1 that also demonstrates higher urinary KIM-1 levels in donors whose kidneys show aberrant initial function (p = 0.03), makes KIM-1 a potential indicator of AKI that may merit further evaluation for its application at the donor bedside. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

SIGINT, EW, and EIW in the Korean People’s Army: An Overview of Development and Organization

DTIC Science & Technology

2005-08-01

Joseph S. Bermudez Jr. "The basic key to victory in modern warfare is to do well in electronic warfare …" Kim Jong Il96 For many years now the...96 “ Kim Jong Il Stresses Electronic Warfare Capabilities,” Radio P’yongyang, 24 September 1999, as cited in FBIS. Bytes and Bullets... Kim Jong Il98 Details concerning how the MPAF developed this understanding, and how it has organized and planned to conduct SIGINT, EW and EIW

JPRS Report East Asia Korea: KULLOJA No 4, April 1987.

DTIC Science & Technology

1988-05-20

Yong -nam] [Text] Ever since he embarked upon the road of revolu- tion in his youth, the great leader Comrade Kim Il-song has constantly dedicated...Comrade Kim Il-song 41090003J Pyongyang KVLLOJA in Korean No 4, Apr 87 pp 81-88 [Article by Kye Ung -tae] [Text] As they mark the respected and...Workers Party published in Pyongyang.] The Great Leader Comrade Kim Il-song Is the Pioneer and Helmsman of the Chuche Cause 1 The Respected and Beloved

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, J; Nguyen, D; O’Brien, R

Purpose: Kilovoltage intrafraction monitoring (KIM) scheme has been successfully used to simultaneously monitor 3D tumor motion during radiotherapy. Recently, an iterative closest point (ICP) algorithm was implemented in KIM to also measure rotations about three axes, enabling real-time tracking of tumor motion in six degrees-of-freedom (DoF). This study aims to evaluate the accuracy of the six DoF motion estimates of KIM by comparing it with the corresponding motion (i) measured by the Calypso; and (ii) derived from kV/MV triangulation. Methods: (i) Various motions (static and dynamic) were applied to a CIRS phantom with three embedded electromagnetic transponders (Calypso Medical) usingmore » a 5D motion platform (HexaMotion) and a rotating treatment couch while both KIM and Calypso were used to concurrently track the phantom motion in six DoF. (ii) KIM was also used to retrospectively estimate six DoF motion from continuous sets of kV projections of a prostate, implanted with three gold fiducial markers (2 patients with 80 fractions in total), acquired during the treatment. Corresponding motion was obtained from kV/MV triangulation using a closed form least squares method based on three markers’ positions. Only the frames where all three markers were present were used in the analysis. The mean differences between the corresponding motion estimates were calculated for each DoF. Results: Experimental results showed that the mean of absolute differences in six DoF phantom motion measured by Calypso and KIM were within 1.1° and 0.7 mm. kV/MV triangulation derived six DoF prostate tumor better agreed with KIM estimated motion with the mean (s.d.) difference of up to 0.2° (1.36°) and 0.2 (0.25) mm for rotation and translation, respectively. Conclusion: These results suggest that KIM can provide an accurate six DoF intrafraction tumor during radiotherapy.« less

IQGAP1 is important for activation of caspase-1 in macrophages and is targeted by Yersinia pestis type III effector YopM.

PubMed

Chung, Lawton K; Philip, Naomi H; Schmidt, Valentina A; Koller, Antonius; Strowig, Till; Flavell, Richard A; Brodsky, Igor E; Bliska, James B

2014-07-01

YopM is a leucine-rich repeat (LRR)-containing effector in several Yersinia species, including Yersinia pestis and Y. pseudotuberculosis. Different Yersinia strains encode distinct YopM isoforms with variable numbers of LRRs but conserved C-terminal tails. A 15-LRR isoform in Y. pseudotuberculosis YPIII was recently shown to bind and inhibit caspase-1 via a YLTD motif in LRR 10, and attenuation of YopM(-) YPIII was reversed in mice lacking caspase-1, indicating that caspase-1 inhibition is a major virulence function of YopM(YPIII). To determine if other YopM proteins inhibit caspase-1, we utilized Y. pseudotuberculosis strains natively expressing a 21-LRR isoform lacking the YLTD motif (YopM(32777)) or ectopically expressing a Y. pestis 15-LRR version with a functional (YopM(KIM)) or inactivated (YopM(KIM) D271A) YLTD motif. Results of mouse and macrophage infections with these strains showed that YopM(32777), YopM(KIM), and YopM(KIM) D271A inhibit caspase-1 activation, indicating that the YLTD motif is dispensable for this activity. Analysis of YopM(KIM) deletion variants revealed that LRRs 6 to 15 and the C-terminal tail are required to inhibit caspase-1 activation. YopM(32777), YopM(KIM), and YopM(KIM) deletion variants were purified, and binding partners in macrophage lysates were identified. Caspase-1 bound to YopM(KIM) but not YopM(32777). Additionally, YopM(KIM) bound IQGAP1 and the use of Iqgap1(-/-) macrophages revealed that this scaffolding protein is important for caspase-1 activation upon infection with YopM(-) Y. pseudotuberculosis. Thus, while multiple YopM isoforms inhibit caspase-1 activation, their variable LRR domains bind different host proteins to perform this function and the LRRs of YopM(KIM) target IQGAP1, a novel regulator of caspase-1, in macrophages. Importance: Activation of caspase-1, mediated by macromolecular complexes termed inflammasomes, is important for innate immune defense against pathogens. Pathogens can, in turn, subvert

YopJ-induced caspase-1 activation in Yersinia-infected macrophages: independent of apoptosis, linked to necrosis, dispensable for innate host defense.

PubMed

Zheng, Ying; Lilo, Sarit; Mena, Patricio; Bliska, James B

2012-01-01

Yersinia outer protein J (YopJ) is a type III secretion system (T3SS) effector of pathogenic Yersinia (Yersinia pestis, Yersinia enterocolitica and Yersinia pseudotuberculosis) that is secreted into host cells. YopJ inhibits survival response pathways in macrophages, causing cell death. Allelic variation of YopJ is responsible for differential cytotoxicity in Yersinia strains. YopJ isoforms in Y. enterocolitica O:8 (YopP) and Y. pestis KIM (YopJ(KIM)) strains have high cytotoxic activity. In addition, YopJ(KIM)-induced macrophage death is associated with caspase-1 activation and interleukin-1β (IL-1β secretion. Here, the mechanism of YopJ(KIM)-induced cell death, caspase-1 activation, and IL-1β secretion in primary murine macrophages was examined. Caspase-3/7 activity was low and the caspase-3 substrate poly (ADP-ribose) polymerase (PARP) was not cleaved in Y. pestis KIM5-infected macrophages. In addition, cytotoxicity and IL-1β secretion were not reduced in the presence of a caspase-8 inhibitor, or in B-cell lymphoma 2 (Bcl-2)-associated X protein (Bax)/Bcl-2 homologous antagonist/killer (Bak) knockout macrophages, showing that YopJ(KIM)-mediated cell death and caspase-1 activation occur independent of mitochondrial-directed apoptosis. KIM5-infected macrophages released high mobility group protein B1 (HMGB1), a marker of necrosis, and microscopic analysis revealed that necrotic cells contained active caspase-1, indicating that caspase-1 activation is associated with necrosis. Inhibitor studies showed that receptor interacting protein 1 (RIP1) kinase and reactive oxygen species (ROS) were not required for cytotoxicity or IL-β release in KIM5-infected macrophages. IL-1β secretion was reduced in the presence of cathepsin B inhibitors, suggesting that activation of caspase-1 requires cathepsin B activity. Ectopically-expressed YopP caused higher cytotoxicity and secretion of IL-1β in Y. pseudotuberculosis-infected macrophages than YopJ(KIM). Wild-type and

The Application of Kidney Injury Molecule-1 to Determine the Duration Between Shockwave Lithotripsy Sessions.

PubMed

Aydin, Hasan R; Irkilata, Lokman; Aydin, Mustafa; Daggulli, Mansur; Taskin, Mehmet H; Demirel, Huseyin C; Adanur, Senol; Moral, Caner; Atilla, Mustafa K; Sancaktutar, Ahmet A

2016-01-01

We aimed to evaluate the role of kidney injury molecule-1 (KIM-1) in determining the intervals between shockwave lithotripsy (SWL) sessions. This was a prospective, controlled study. It included 40 patients with unilateral kidney stones and 40 healthy persons of a similar age group as controls. The patients' midflow urine samples were collected before SWL and 1 hour, 1 day, 1 week, and 1 month after the procedure. The average age in the SWL and control groups was 45 ± 14 and 39 ± 15 years, respectively (P = 0.336). The average KIM-1 value before SWL was 0.74 ± 0.35 ng/mL, which was significantly higher than that of the control group (0.51 ± 0.14 ng/mL) (P < 0.001). Similarly, the average values of the urine samples after SWL were higher than those of the control group (P < 0.001). When the KIM-1 values of the patients given SWL were compared within the group, the KIM-1 values 1 hour (1.06 ± 0.51) and 1 day (0.99 ± 0.67) after the procedure were statistically clearly higher than those before the procedure (P < 0.001) and statistically clearly higher than those of the control group (P = 0.005). The KIM-1 values 1 week and 1 month after the procedure were not significantly different than the preprocedure values (P = 0.652 and P = 0.747, respectively). KIM-1 is a noninvasive biomarker that may be used to show renal damage because of stones and early-stage renal damage linked to SWL. In addition, post-SWL KIM-1 values may be used to determine the interval between SWL sessions.

An objective assessment of children's physical activity during the Keep It Moving! after-school program.

PubMed

Schuna, John M; Lauersdorf, Rebekah L; Behrens, Timothy K; Liguori, Gary; Liebert, Mina L

2013-02-01

After-school programs may provide valuable opportunities for children to accumulate healthful physical activity (PA). This study assessed the PA of third-, fourth-, and fifth-grade children in the Keep It Moving! (KIM) after-school PA program, which was implemented in an ethnically diverse and low socioeconomic status school district in Colorado Springs, Colorado. The PA of KIM participating children (N = 116) at 4 elementary schools was objectively assessed using ActiGraph accelerometers and the System for Observing Fitness Instruction Time (SOFIT). Linear mixed-effects models or generalized linear mixed-effects models were used to compare time spent in sedentary (SED) behaviors, light PA (LPA), moderate PA (MPA), vigorous PA (VPA), and moderate-to-vigorous PA (MVPA) between genders and weight status classifications during KIM sessions. Children accumulated 7.6 minutes of SED time, 26.9 minutes of LPA, and 22.2 minutes of MVPA during KIM sessions. Boys accumulated less SED time (p < .05) and LPA (p = .04) than girls, but accumulated more MPA (p = .04), VPA (p = .03), and MVPA (p = .03). Overweight/obese children accumulated more LPA (p = .04) and less VPA (p < .05) than nonoverweight children. SOFIT data indicated that children spent a considerable proportion of KIM sessions being very active (12.4%), walking (36.0%), or standing (40.3%). The KIM program provides opportunities for disadvantaged children to accumulate substantial amounts of MVPA (>20 minutes per session) in an effort to meet current PA guidelines. © 2013, American School Health Association.

Attentional distractor interference may be diminished by concurrent working memory load in normal participants and traumatic brain injury patients.

PubMed

Gil-Gómez de Liaño, Beatriz; Umiltà, Carlo; Stablum, Franca; Tebaldi, Francesca; Cantagallo, Anna

2010-12-01

A reduction in congruency effects under working memory (WM) load has been previously described using different attentional paradigms (e.g., Kim, Kim, & Chun, 2005; Smilek, Enns, Eastwood, & Merikle, 2006). One hypothesis is that different types of WM load have different effects on attentional selection, depending on whether a specific memory load demands resources in common with target or distractor processing. In particular, if information in WM is related to the distractors in the selective attention task, there is a reduction in distraction (Kim et al., 2005). However, although previous results seem to point to a decrease in interference under high WM load conditions (Kim et al., 2005), the lack of a neutral baseline for the congruency effects makes it difficult to differentiate between a decrease in interference or in facilitation. In the present work we included neutral trials in the task introduced by Kim et al. (2005) and tested normal participants and traumatic brain injury patients. Results support a reduction in the processing of distractors under WM load, at least for incongruent trials in both groups. Theoretical as well as applied implications are discussed. Copyright © 2010 Elsevier Inc. All rights reserved.

Translations on North Korea No. 495

DTIC Science & Technology

1976-12-02

Yun Ch’i-ho Hwang Ch’ol-san Kim Yong -yon comrade, KPA general, political committee member, and DPRK minister of peoples armed forces colonel...t’ae " So Kwan-hi functionary of the sector concerned Chong Song-nam Kim Sok-chin So Nam-sin Han Pyong- yong Wang Kyong-hak Ch’oe Sang-muk...Chin-t’ae Kim Sok-ki Yi Chong-mok Ch’oe Tu-kwang Han Su-kil Yi Yong -ch’ang [Pyongyang NODONG SINMUN in Korean 8 Oct 76 p 3] LOYALTY OATH

A HEL Testbed for High Accuracy Beam Pointing and Control

DTIC Science & Technology

2009-07-01

Control by Dojong Kim, Duane Frist, Jae Jun Kim, Brij Agrawal 01 July 2009 Approved for......distant targets immediately. The issues of the technology on the HEL system include various types of high energy laser devices, beam control systems

Compassion and Curiosity - TCGA

Cancer.gov

William Kim, M.D., is motivated by two things: compassion and curiosity. Dr. Kim has taken these dual motivations and created a career in which he cares directly for patients and spearheads research that may lead to improved treatment options.

TH-AB-202-12: The First Clinical Implementation of a Real-Time Six Degree of Freedom Tracking System During Radiation Therapy

DOE Office of Scientific and Technical Information (OSTI.GOV)

Nguyen, D; Kim, J; O’Brien, R

2016-06-15

Purpose: In current practice, imaging is typically performed prior to treatment; the cancer target motion during treatment is unknown. We present the first clinical implementation of real time Kilovoltage Intrafraction Monitoring (KIM) system which tracks the cancer target translational and rotational motions during treatment. Methods: KIM technology: KIM estimates the 3D position of the target tumour based on segmented 2D positions of the three implanted fiducials in each of the kV images (125 kV, 10 mA at 11 fps) taken continuously during the treatment arc. The 2D-3D target estimation is based on a probability distribution function, obtained during pre-treatment CBCT.more » Rotations about each axis with the centroid of the markers as the pivot were calculated using the iterative closest point algorithm in real time. Patient: A patient with prostate adenocarcinoma undergoing stereotactic body radiotherapy (SBRT) with 36.25 Gy delivered in 5 fractions (Varian TrueBeam, 6X, VMAT) was enrolled in the study. The trial complies with Australian ethical and regulatory standards. Results: Of the 5 fractions of treatment the patient received, KIM was utilised successfully in 4 fractions with 3 couch shifts due to large persistent prostate movements (>2mm for more than 5 seconds). KIM translational accuracy and precision in comparison with post treatment kV-MV triangulation are 0.28±0.59 mm, −0.19±0.25 mm and 0.23±0.69 mm in the Left-Right, Superior-Inferior and Anterior-Posterior directions, respectively. KIM rotational accuracy as compared with triangulation is: 0.429°±2.22°, −0.44°±4.7° and 0.06°±1.08° in the roll, pitch and yaw direction, respectively. Conclusion: The first six degree of freedom KIM system was successfully implemented clinically. The presented KIM system has sub-millimeters accuracy and precision in all three translational axes, and less than 1° of mean error in all three rotational axes. Acknowledgement: This work is supported by

Managing Inventory At A Transitional Facility

NASA Technical Reports Server (NTRS)

Hutchins, Henry A.

1993-01-01

Kennedy Inventory Management System, KIMS, geared to needs of facility in transition from research and development to manufacturing. Operated jointly by several contractors at Kennedy Space Center, KIMS designed to reduce cost and increase efficiency of fabrication and maintenance of spaceflight hardware.

Resilient Localization for Sensor Networks in Outdoor Environments

DTIC Science & Technology

2004-06-01

Sensor Networks in Outdoor Environments by YoungMin Kwon, Kirill Mechitov, Sameer Sundresh, Wooyoung Kim and Gul Agha June 2004 Report...Environments YoungMin Kwon, Kirill Mechitov, Sameer Sundresh, Wooyoung Kim and Gul Agha Department of Computer Science University of Illinois at Urbana

Mapping biological ideas: Concept maps as knowledge integration tools for evolution education

NASA Astrophysics Data System (ADS)

Schwendimann, Beat Adrian

-specific form of concept map, called Knowledge Integration Map (KIM), which aims to help learners connect ideas across levels (for example, genotype and phenotype levels) towards an integrated understanding of evolution. Using a design-based research approach (Brown, 1992; Cobb et al., 2003), three iterative studies were implemented in ethically and economically diverse public high schools classrooms using the web-based inquiry science environment (WISE) (Linn et al., 2003; Linn et al., 2004). Study 1 investigates concept maps as generative assessment tools. Study 1A compares the concept map generation and critique process of biology novices and experts. Findings suggest that concept maps are sensitive to different levels of knowledge integration but require scaffolding and revision. Study 1B investigates the implementation of concept maps as summative assessment tools in a WISE evolution module. Results indicate that concept maps can reveal connections between students' alternative ideas of evolution. Study 2 introduces KIMs as embedded collaborative learning tools. After generating KIMs, student dyads revise KIMs through two different critique activities (comparison against an expert or peer generated KIM). Findings indicate that different critique activities can promote the use of different criteria for critique. Results suggest that the combination of generating and critiquing KIMs can support integrating evolution ideas but can be time-consuming. As time in biology classrooms is limited, study 3 distinguishes the learning effects from either generating or critiquing KIMs as more time efficient embedded learning tools. Findings suggest that critiquing KIMs can be more time efficient than generating KIMs. Using KIMs that include common alternative ideas for critique activities can create genuine opportunities for students to critically reflect on new and existing ideas. Critiquing KIMs can encourage knowledge integration by fostering self-monitoring of students' learning

78 FR 79673 - South Atlantic Fishery Management Council; Public Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-31

... Management Council, 4055 Faber Place Drive, Suite 201, North Charleston, SC 29405, or via email to... contacting Kim Iverson, Public Information Officer, South Atlantic Fishery Management Council, 4055 Faber... INFORMATION CONTACT: Kim Iverson, South Atlantic Fishery Management Council, 4055 Faber Place Drive, Suite 201...

BATTLE (Biomarker-based Approaches of Targeted Therapy for Lung Cancer Elimination)

DTIC Science & Technology

2011-04-01

bleach- ing. IF microscopy was performed using a Zeiss Axioplan fluorescence  microscope ( Carl  Zeiss Inc.) equipped with a 100-W Hg lamp and narrow...laser scanning microscope ( Carl  Zeiss Inc.) equipped with an argon  laser (458/477/488/514 nm, 30 mW), HeNe laser (413 nm, 1 mW and 633  nm, 5 mW), LSM...Protein-3 (IGFBP-3) in Epithelial IGF-Induced Lung Cancer Development Woo-Young Kim, Mi- Jung Kim,* Hojin Moon,* Ping Yuan, Jin-Soo Kim, Jong-Kyu Woo

The Psychometric Properties of the Kentucky Inventory of Mindfulness Skills in Clinical Populations

ERIC Educational Resources Information Center

Baum, Corinna; Kuyken, Willem; Bohus, Martin; Heidenreich, Thomas; Michalak, Johannes; Steil, Regina

2010-01-01

The Kentucky Inventory of Mindfulness Skills (KIMS) is a well-validated multidimensional questionnaire measuring dimensions of mindfulness on four scales: Observing, Describing, Act With Awareness, and Accept Without Judgment. Even though the KIMS has been used in several clinical studies no information is available about the psychometric…

Comment on 'Amplification of endpoint structure for new particle mass measurement at the LHC'

DOE Office of Scientific and Technical Information (OSTI.GOV)

Barr, A. J.; Gwenlan, C.; Young, C. J. S.

2011-06-01

We present a comment on the kinematic variable m{sub CT2} recently proposed in Won Sang Cho, Jihn E. Kim, and Ji-Hun Kim, Phys. Rev. D 81, 095010 (2010). The variable is designed to be applied to models such as R-parity conserving supersymmetry (SUSY) when there is pair production of new heavy particles each of which decays to a single massless visible and a massive invisible component. It was proposed by Cho, Kim, and Kim that a measurement of the peak of the m{sub CT2} distribution could be used to precisely constrain the masses of the SUSY particles. We show that,more » for the an example characterized by direct squark decays, when standard model backgrounds are included in simulations, the sensitivity of the m{sub CT2} variable to the SUSY particle masses is more seriously impacted for m{sub CT2} than for other previously proposed variables.« less

Kidney Injury Molecule-1 Outperforms Traditional Biomarkers of Kidney Injury in Multi-site Preclinical Biomarker Qualification Studies

PubMed Central

Vaidya, Vishal S.; Ozer, Josef S.; Frank, Dieterle; Collings, Fitz B.; Ramirez, Victoria; Troth, Sean; Muniappa, Nagaraja; Thudium, Douglas; Gerhold, David; Holder, Daniel J.; Bobadilla, Norma A.; Marrer, Estelle; Perentes, Elias; Cordier, André; Vonderscher, Jacky; Maurer, Gérard; Goering, Peter L.; Sistare, Frank D.; Bonventre, Joseph V.

2010-01-01

Kidney toxicity accounts for a significant percentage of morbidity and drug candidate failure. Serum creatinine (SCr) and blood urea nitrogen (BUN) have been used to monitor kidney dysfunction for over a century but these markers are insensitive and non-specific. In multi-site preclinical rat toxicology studies the diagnostic performance of urinary kidney injury molecule-1 (Kim-1) was compared to traditional biomarkers as predictors of kidney tubular histopathologic changes, currently considered the “gold standard” of nephrotoxicity. In multiple models of kidney injury, urinary Kim-1 significantly outperformed SCr and BUN. The area under the receiver operating characteristic curve for Kim-1 was between 0.91 and 0.99 as compared to 0.79 to 0.9 for BUN and 0.73 to 0.85 for SCr. Thus urinary Kim-1 is the first injury biomarker of kidney toxicity qualified by the FDA and EMEA and is expected to significantly improve kidney safety monitoring. PMID:20458318

The effect of image force and diffusion on the deposition of ultrafine particle to vegetation

NASA Astrophysics Data System (ADS)

Lin, M. Y.; Katul, G. G.; Huang, C. W.; CHU, C. R.; Khlystov, A.

2017-12-01

Ultrafine particles (UFP) along with their sources and sinks are gaining significant attention due to their dual role in cloud microphysics and human health. Due to its expansive areal extent, vegetation is a significant sink for UFP thus prompting interest in how UFP deposit onto vegetated surfaces. Single fiber theory reasonably explains deposition of zero charge UFP onto vegetation by treating vegetation as filter media. However, the ability of the single fiber theory to predict deposition of charged UFP onto vegetation remains unknown and frames the scope of this presentation. Wind tunnel experiments are used to investigate UFP deposition (size range 12.6 - 102 nm) onto Juniper branches (Juniperus chinesis) and their results are interpreted using single fiber theory. Three different wind speeds (0.3, 0.6, and 0.9 m/s) are investigated to study deposition of singly-charged particles and these deposition values are contrasted with neutrally charged particles. The wind tunnel experiments indicate that single fiber theory can be used to describe deposition of singly-charged particles onto vegetation if both the image force and Brownian diffusion are simultaneously considered. The image force was found to be proportional to KIM0.5 when the image force dimensionless number (KIM) is smaller than 10-8, a common condition for singly charged UFP particle. The proportionality constant was found to be 27.6 (i.e. 27.6×KIM0.5) and is larger than a previously reported value (9.7) derived for KIM between 10-7 10-5, primarily due to the lower KIM (<10-8) in this study. Another study also showed that this proportionality constant increases with decreasing KIM. With this representation for the image force, the single fiber filtration model and measurements agree to within 20%. The work here offers a new perspective on the role of image force at small KIM (10-10 10-8) and its role in enhanced deposition of charged UFP onto vegetation.

Task Complexity, the Cognition Hypothesis, and Interaction in CMC and FTF Environments

ERIC Educational Resources Information Center

Baralt, Melissa Lorrain

2010-01-01

The construct of cognitive complexity has played an increasingly important role in studies on task design, which aim to explore how increases in the cognitive complexity of tasks differentially mediate interaction and learning outcomes (Kim, 2009; Gilabert, Baron, & Llanes, 2009; Kim & Tracy-Ventura, forthcoming; Nuevo, 2006; Revesz, 2009,…

Proceedings of the Annual Meeting of the Association for Education in Journalism and Mass Communication (81st, Baltimore, Maryland, August 5-8, 1998). Advertising.

ERIC Educational Resources Information Center

Association for Education in Journalism and Mass Communication.

The Advertising section of the Proceedings contains the following 18 papers: "The Birth of Adwatches: Political Advertising Becomes Front-Page News" (Jennifer Greer); "A Cross-Cultural Comparison of the Effects of Source Credibility on Attitudes and Behavioral Intentions" (Kak Yoon, Choong Hyun Kim, and Min-Sun Kim);…

Korean Spring? An Analysis of the Arab Spring and Its Relevance for North Korea

DTIC Science & Technology

2012-06-08

Spring. North Korea is undergoing a transition following the death of Kim Jong II. This research thesis analyzed the conditions that existed during the...transition following the death of Kim Jong II. This research thesis analyzed the conditions that existed during the Arab Spring in Egypt, Libya and Syria...

The Genomic Actions and Functional Implications of Nuclear PRLr in Human Breast Carcinoma

DTIC Science & Technology

2010-03-01

pregnant mice; loss of this process may contribute to 171 gestational diabetes mellitus (Karnik, et al. 2007). 172 Ingenuity Pathway Analysis (IPA...of pancreatic beta-cells in pregnant mice and promotes gestational 403 diabetes mellitus . Science 318 806-809. 404 Kim J, Choi TG, Ding Y, Kim Y, Ha

Prospective Evaluation of Mesopic Night Vision and Night Vision Goggle Visual Acuity After Photorefractive Keratectomy (PRK)

DTIC Science & Technology

2005-03-01

off-label use of custom wavefront-guided treatment has demonstrated potential for reducing some QoV problems; however, early custom- ablation LASIK ...10): 1934-40. 66. Lee JB, Ryu CH, Kim EK,, Kim HB. Comparison of tear secretion and tear film instability after PRK and LASIK . J Cataract Surg

Assessment of Mindfulness with the French Version of the Kentucky Inventory of Mindfulness Skills in Community and Borderline Personality Disorder Samples

ERIC Educational Resources Information Center

Nicastro, Rosetta; Jermann, Francoise; Bondolfi, Guido; McQuillan, Annabel

2010-01-01

This article explores mindfulness skills in community and borderline personality disorder (BPD) samples. Study 1 includes 173 community volunteers and explores the psychometric properties of the French version of the Kentucky Inventory of Mindfulness Skills (KIMS). Study 2 explores the KIMS factor structure in 130 BPD patients and compares KIMS…

We're Still Here: Community-Based Art, the Scene of Education, and the Formation of Scene

ERIC Educational Resources Information Center

Kim, Charles; Miyamoto, Nobuko

2013-01-01

In this cross-generational dialogue, authors Charles Kim and Nobuko Miyamoto engage in a creative exploration of community-based art, contemporary Asian American identity, and the possibilities of creativity within educational spaces. Using the ideas of John Dewey as a foundation, Kim and Miyamoto offer their dialogues, experiences, and analyses…

Attentional Distractor Interference May Be Diminished by Concurrent Working Memory Load in Normal Participants and Traumatic Brain Injury Patients

ERIC Educational Resources Information Center

de Liano, Beatriz Gil-Gomez; Umilta, Carlo; Stablum, Franca; Tebaldi, Francesca; Cantagallo, Anna

2010-01-01

A reduction in congruency effects under working memory (WM) load has been previously described using different attentional paradigms (e.g., Kim, Kim, & Chun, 2005; Smilek, Enns, Eastwood, & Merikle, 2006). One hypothesis is that different types of WM load have different effects on attentional selection, depending on whether a specific memory load…

Kidney injury molecule-1 and microalbuminuria levels in Zambian population: biomarkers of kidney injury.

PubMed

Zulu, Mildred; Kaile, Trevor; Kantenga, Timothy; Chileshe, Chisanga; Nkhoma, Panji; Sinkala, Musalula

2016-01-01

Kidney injury affects renal excretion of plasma analytes and metabolic waste products with grave pathologic consequences. Early detection, thus of kidney injury is essential for injury specific intervention that may avert permanent renal damage and delay progression of kidney injury. We aimed to evaluate Kidney Injury Molecule-1 (KIM-1) and Microalbuminuria (MAU), as biomarkers of kidney injury, in comparison with creatinine. We compared the levels of urine MAU, urine KIM-1 and other plasma biochemical tests in specimens from 80 individuals with and without kidney disease. We found no difference in KIM-1 levels between the kidney disease group (2.82± 1.36ng/mL) and controls (3.29 ± 1.14ng/mL), p = 0.122. MAU was higher in participants with kidney disease (130.809± 84.744 µg/mL) than the controls (15.983± 20.442µg/mL), p ?0.001. KIM-1 showed a weak negative correlation with creatinine (r = -0.279, p = 0.09), whereas MAU was positively correlated with creatinine in participants with kidney disease with statistical significance (r = 0.556, p = 0.001). The study demonstrated that in Zambian setting MAU and creatinine are sensitive biomarkers in the diagnosis of kidney damage. We moreover propose further evaluation of KIM-1 as a biomarker of kidney injury.

Kidney injury molecule-1 and microalbuminuria levels in Zambian population: biomarkers of kidney injury

PubMed Central

Zulu, Mildred; Kaile, Trevor; Kantenga, Timothy; Chileshe, Chisanga; Nkhoma, Panji; Sinkala, Musalula

2016-01-01

Introduction Kidney injury affects renal excretion of plasma analytes and metabolic waste products with grave pathologic consequences. Early detection, thus of kidney injury is essential for injury specific intervention that may avert permanent renal damage and delay progression of kidney injury. We aimed to evaluate Kidney Injury Molecule-1 (KIM-1) and Microalbuminuria (MAU), as biomarkers of kidney injury, in comparison with creatinine. Methods We compared the levels of urine MAU, urine KIM-1 and other plasma biochemical tests in specimens from 80 individuals with and without kidney disease. Results We found no difference in KIM-1 levels between the kidney disease group (2.82± 1.36ng/mL) and controls (3.29 ± 1.14ng/mL), p = 0.122. MAU was higher in participants with kidney disease (130.809± 84.744 µg/mL) than the controls (15.983± 20.442µg/mL), p ?0.001. KIM-1 showed a weak negative correlation with creatinine (r = -0.279, p = 0.09), whereas MAU was positively correlated with creatinine in participants with kidney disease with statistical significance (r = 0.556, p = 0.001). Conclusion The study demonstrated that in Zambian setting MAU and creatinine are sensitive biomarkers in the diagnosis of kidney damage. We moreover propose further evaluation of KIM-1 as a biomarker of kidney injury. PMID:27642395

Clinical Significance of Persistent Global and Focal Computed Tomography Nephrograms After Cardiac Catheterization and Their Relationships to Urinary Biomarkers of Kidney Damage and Procedural Factors: Pilot Study.

PubMed

Chu, Lisa L; Katzberg, Richard W; Solomon, Richard; Southard, Jeffrey; Evans, Scott J; Li, Chin-Shang; McDonald, Jennifer S; Payne, Catherine; Boone, John M; RamachandraRao, Satish P

2016-12-01

We evaluate the relationships between persistent computed tomography (CT) nephrograms and acute kidney injury after cardiac catheterization (CC). We compare changes in urinary biomarkers kidney injury molecule 1 (KIM-1), cystatin C, and serum creatinine to procedural factors. From 159 eligible patients without renal insufficiency (estimated glomerular filtration rate >60 mL/min), 40 random patients (age range, 42-81 years; mean age, 64 years; 25 men, 15 women) gave written informed consent to undergo unenhanced CT limited to their kidneys 24 hours after CC. Semiquantitative assessment for global nephrograms and quantitative assessment of focal nephrograms in each kidney was performed. Computed tomography attenuation (Hounsfield units) of the renal cortex was measured. Serum creatinine, KIM-1, and cystatin C were measured before and 24 hours after CC. Robust linear regression showed that both relative changes in KIM-1 and cystatin C had positive relationships with kidney CT attenuation (P = 0.012 and 0.002, respectively). Spearman rank correlation coefficient showed that both absolute changes and relative changes in KIM-1 and cystatin C had positive correlations with global nephrogram grades (P = 0.025 and 0.040, respectively, for KIM-1; P = 0.013 and 0.019, respectively, for cystatin C). Global nephrograms on unenhanced CT in patients who have undergone CC are significantly correlated with changes in urinary biomarkers for kidney damage.

Criminal Sovereignty: Understanding North Korea’s Illicit International Activities

DTIC Science & Technology

2010-03-01

Kwang-min, “The Political Economy of the North Korean Famine,” Seoul, Korea: Sidae Jungsin Publishers, 2005 (in Korean). 61. Kim Kwang-jin, “The...National Economy,” Sidae Jungsin Journal, Summer 2008 (in Korean), available from www.sdjs.co.kr. 67. Ibid. 68. See Jack Kim, “North Korea leader

Loran-C flight test software

NASA Technical Reports Server (NTRS)

Nickum, J. D.

1978-01-01

The software package developed for the KIM-1 Micro-System and the Mini-L PLL receiver to simplify taking flight test data is described along with the address and data bus buffers used in the KIM-1 Micro-system. The interface hardware and timing are also presented to describe completely the software programs.

Transfer-Free Batch Fabrication of Large-Area Suspended Graphene Membranes

DTIC Science & Technology

2010-01-01

Sikes, K. J.; Jiang, Z.; Klima, M.; Fudenberg, G.; Hone, J.; Kim, P.; Stormer , H. L. Ultrahigh Electron Mobility in Suspended Graphene. Solid State...Commun. 2008, 146, 351–355. 14. Bolotin, K. I.; Ghahari, F.; Shulman, M. D.; Stormer , H. L.; Kim, P. Observation of the Fractional Quantum Hall Effect in

Changes in Educational Practices: A Multiple Case Study Investigating Faculty Implemented Changes in Educational Practices Designed to Meet the Academic Needs of the Contemporary Student at a Southwestern Community College

ERIC Educational Resources Information Center

Tompkins, David K.

2017-01-01

For the past few decades, the trend of first generation low-economic status community college students, considerably comprised of immigrants, has continued to grow at a significant rate (Connell, 2008; Ray, 2013; Kim & Diaz, 2013c; Kim, 2014). Community colleges are encountering challenges that were previously viewed as minimal or secondary to…

"When Stones Falls": A Conceptual-Functional Account of Subject-Verb Agreement in Persian

ERIC Educational Resources Information Center

Sharifian, Farzad; Lotfi, Ahmad R.

2007-01-01

Most linguistic studies of subject-verb agreement have thus far attempted to account for this phenomenon in terms of either syntax or semantics. Kim (2004) [Kim, J., 2004. Hybrid agreement in English. Linguistics 42 (6), 1105-1128] proposes a "hybrid analysis", which allows for a morphosyntactic agreement and a semantic agreement within the same…

Institutional Change through Assessment: Contrasting Case Studies

ERIC Educational Resources Information Center

Deess, E. Pierre; Elliot, Norbert

2009-01-01

The framework for understanding the management difference is neatly captured by the "red ocean" and "blue ocean" strategies described by W. Chan Kim and Renee Mauborgne in "Blue Ocean Strategy" (Kim & Mauborgne, 2004). In the original, the terms refer to alternative market strategies. Red ocean means competition in a market defined by a zero sum…

North Korea’s Foreign Policy Towards the United States

DTIC Science & Technology

2006-09-01

NDC ),[8] which has been chaired by Kim Jong Il since 1993. Kim has been using his positions as NDC chairman and KWP General-Secretary[9] to exert...overview of North Korea’s tunnels and underground facilities, see Barbara Demick, “ N. Korea’s Ace in the Hole,” The Los Angeles Times, November 14

Creating Learning: A Korean Drummer's Lifelong Quest to Be the Best

ERIC Educational Resources Information Center

Kang, Dae Joong

2010-01-01

In this article, the author interrogates how one famous Korean traditional drummer Mr. Myong-hwan Kim's lifelong learning is affected by the sociocultural and historical context as it contributes to the construction of his life. This article analyzed an oral history book that contains Mr. Kim's interview narratives since he died 20 years ago.…

Topological Quantum Information in a 3D Neutral Atom Array

DTIC Science & Technology

2015-01-02

being only weakly in the Lamb-Dicke Figure 1: Projection sideband cooling. The pink curves show the (from left to right) Δn=+1,0,-1 and-2 transitions...45 154012 (2012). 4. C. Knoernschild, T. Kim, P. Maunz, S. G. Crain, and J. Kim, “Stable optical phase modulation with micromirrors ,” Opt. Express

Electron Transport in Graphene From a Diffusion-Drift Perspective

DTIC Science & Technology

2010-02-24

Tung, M.E. Schwartz, M. Takita, Y.-J. Wang, P. Kim, and H.L. Stormer , “Cyclotron resonance in bilayer graphene,” Phys. Rev. Lett. 100, 087403 (2008...Dec. 2004. [3] K. I. Bolotin, K. J. Sikes, Z. Jiang, M. Klima, G. Fudenberg, J. Hone, P. Kim, and H. L. Stormer , “Ultrahigh electron mobility in

Strain-Induced Pseudo-Magnetic Fields Greater Than 300 Tesla in Graphene Nanobubbles

DTIC Science & Technology

2010-07-30

H. L. Stormer , P. Kim, Nature 438, 201 (2005). 8. K. S. Novoselov et al., Nature 438, 197 (2005). 9. K. I. Bolotin, F. Ghahari, M. D. Shulman, H. L... Stormer , P. Kim, Nature 462, 196 (2009). 10. X. Du, I. Skachko, F. Duerr, A. Luican, E. Y. Andrei, Nature 462, 192 (2009). 11. V. M. Pereira, A. H

A Compendium of Position Papers from the Workshop on Architectures for Free Space Digital Optical Computing Held in Vail, Colorado on 28-30 January 1991

DTIC Science & Technology

1991-11-24

Opt. 25, 3078 (1986). [4] P. S. Guilfoyle and W. I. Wiley, AppL Opt. 27, 1661 (1987). (51 Y. Li, A. Kostrzewski, D. H. Kim, and G. Eichmann , Opt. Lett...13, 895 (1988). (61 M. J. Murdocca, Ph.D. thesis (State University of New Jersey, 1988). [7] Y. Li, D. H. Kim, A. Kostrzewski, and G. Eichmann , Opt

Hydrophilic Cucurbit[7]uril-Pseudorotaxane-Anchored-Monolayer-Protected Gold Nanorods

DTIC Science & Technology

2013-03-20

FULL PAPER DOI:10.1002/ejic.201300010 Hydrophilic Cucurbit[7]uril-Pseudorotaxane-Anchored- Monolayer-Protected Gold Nanorods Xiang Ma,[a] Yuhua Xue... Cao , Q. Wang, H. Tian, Chem. Commun. 2011, 47, 3559–3561. [8] a) I. Hwang, K. Baek, M. Jung, Y. Kim, K. M. Park, D. W. Lee, N. Selvapalam, K. Kim, J. Am

Optical Investigation of Transition Metal Implanted Wide Band Gap Semiconductors

DTIC Science & Technology

2005-03-01

T., Overberg, M. E., Frazier, R., Abernathy, C. R., Pearton, S. J., Kim, Jihyun , and Ren, F. Optical and electrical properties of GaMnN films grown...Yuldashev, Sh. U., Leem, J. H., Park , C. S., Fu, D. J., Kim, H. J. and Kang, T. W. Optical and magnetic measurements of p-type GaN epilayers

Every Feather Tells a Story

ERIC Educational Resources Information Center

Chessin, Debby; Chessin, Laura

2006-01-01

For Mr. Kim's fifth-grade students, recess is not just for playing and getting exercise! One spring, he observed a small group of his students near their class bluebird box, examining various bird feathers found on the ground. Building on students' natural curiosity, Mr. Kim purchased some feathers for further exploration in the classroom. He was…

An Investigation of the Factor Structure of the Torrance Tests of Creative Thinking

ERIC Educational Resources Information Center

Bart, William M.; Hokanson, Brad; Can, Iclal

2017-01-01

This study investigated the factorial structure of the Torrance Tests of Creative Thinking (TTCT) Figural Form A with an aim to find out whether the two-factor structure of creative thinking established by Kim and Kim, Cramond, and Bandalos holds true for the older participants. Data were gathered from 996 8th grade students and 748 11th grade…

Electronic Struture and Quantum Effects of Thin Metal Film Systems Based on Silicon Carbide

DTIC Science & Technology

2013-05-01

324, 924 (2009). [33] K. S. Novoselov et al., Nature (London) 438, 197 (2005). [34] Y. Zhang, Y.-W. Tan, H. L. Stormer , and P. Kim, Nature (London...Zhang, Y.-W. Tan, H. L. Stormer , and P. Kim, Nature (London) 438, 201 (2005). [6] K. S. Novoselov et al., Nature Phys. 2, 177 (2006). [7] E. McCann and V

Extraordinary magnetoresistance in shunted chemical vapor deposition grown graphene devices

DTIC Science & Technology

2011-07-01

Lett. 10, 3962 (2010). 9Z. Jiang, Y. Zhang, Y.-W. Tan, H. L. Stormer , and P. Kim, Solid State Commun. 143 14 (2007). 10A. K. Geim and K. S. Novoselov...L. Stormer , U. Zeitler, J. C. Maan, G. S. Boebinger, P. Kim, and A. K. Geim, Science 9, 1379 (2007). 20F. Meier, L. Zhou, J. Wiebe, and R

Preparation for a Clinical Trial Using Adoptive Transfer of Tumor-Reactive TGF_Beta-Insensitive CD8+ T Cells for Treatment of Prostate Cancer

DTIC Science & Technology

2006-07-01

Park,1 Robert E. Meyer,2 Shilajit Kundu,1 Michael Pins,2 Borko Javonovic,3 Timothy Kuzel,4 Seong-Jin Kim,5 Luk Van Parijs,6 Norm Smith,1 Larry Wong,1...cycle Qiang Zhang,1 Ximing Yang,2,5 Shilajit D. Kundu,1 Michael Pins,2,5 Borko Javonovic,3,5 Robert Meryer,2 Seong-Jin Kim,7 Norman M. Greenberg,8

Immune Cells, if Rendered Insensitive to Transforming Growth Factorbeta, Can Cure Prostate Cancer

DTIC Science & Technology

2007-02-01

Robert E. Meyer,2 Shilajit Kundu,1 Michael Pins,2 Borko Javonovic,3 Timothy Kuzel,4 Seong-Jin Kim,5 Luk Van Parijs,6 Norm Smith,1 Larry Wong,1 Norman M...Zhang,1 Ximing Yang,2,5 Shilajit D. Kundu,1 Michael Pins,2,5 Borko Javonovic,3,5 Robert Meryer,2 Seong-Jin Kim,7 Norman M. Greenberg,8 Timothy Kuzel

From Tununak to Beaufort: Taking a Critical Inquiry Stance as a First Year Teacher

ERIC Educational Resources Information Center

Fecho, Bob; Price, Kim; Read, Chris

2004-01-01

In this article, the authors show how two first year teachers a continent apart--Kim in the village of Tununak on the Bering Sea in Alaska and Chris in Beaufort, South Carolina, on the Atlantic Ocean--were able to take inquiry stances on their classrooms. In particular, through analysis of e-mails written in Chris' and Kim's first years of…

Ratio-based estimators for a change point in persistence.

PubMed

Halunga, Andreea G; Osborn, Denise R

2012-11-01

We study estimation of the date of change in persistence, from [Formula: see text] to [Formula: see text] or vice versa. Contrary to statements in the original papers, our analytical results establish that the ratio-based break point estimators of Kim [Kim, J.Y., 2000. Detection of change in persistence of a linear time series. Journal of Econometrics 95, 97-116], Kim et al. [Kim, J.Y., Belaire-Franch, J., Badillo Amador, R., 2002. Corringendum to "Detection of change in persistence of a linear time series". Journal of Econometrics 109, 389-392] and Busetti and Taylor [Busetti, F., Taylor, A.M.R., 2004. Tests of stationarity against a change in persistence. Journal of Econometrics 123, 33-66] are inconsistent when a mean (or other deterministic component) is estimated for the process. In such cases, the estimators converge to random variables with upper bound given by the true break date when persistence changes from [Formula: see text] to [Formula: see text]. A Monte Carlo study confirms the large sample downward bias and also finds substantial biases in moderate sized samples, partly due to properties at the end points of the search interval.

Theory, Observation, and Validation: Commentary on Almond, Kim, Velasquez, & Shute

ERIC Educational Resources Information Center

Markus, Keith A.

2014-01-01

Keith Marcus congratulates Almond et al. on an interesting article bringing together two topics that are important to the field of testing. He states that some aspects of the exposition came across as not yet fully developed, as if the manuscript had been hurried to press. In this commentary, he attempts to expand aspects of the article, which he…

Stand-alone development system using a KIM-1 microcomputer module

NASA Technical Reports Server (NTRS)

Nickum, J. D.

1978-01-01

A small microprocessor-based system designed to: contain all or most of the interface hardware, designed to be easy to access and modify the hardware, to be capable of being strapped to the seat of a small general aviation aircraft, and to be independent of the aircraft power system is described. The system is used to develop a low cost Loran C sensor processor, but is designed such that the Loran interface boards may be removed and other hardware interfaces inserted into the same connectors. This flexibility is achieved through memory-mapping techniques into the microprocessor.

Classifying the Quantum Phases of Matter

DTIC Science & Technology

2015-01-01

Kim related entanglement entropy to topological storage of quantum information [8]. Michalakis et al. showed that a particle-like excitation spectrum...Perturbative analysis of topological entanglement entropy from conditional independence, Phys. Rev. B 86, 254116 (2012), arXiv:1210.2360. [3] I. Kim...symmetries or long-range entanglement ), (2) elucidating the properties of three-dimensional quantum codes (in particular those which admit no string-like

Stability Models for Augmentor Design Tools and Technology Assessment

DTIC Science & Technology

2010-07-14

AFRL experiments of the flame holders proposed here for further validation. 63 Appendix A A.1 Contributors Prof. Heinz Pitsch Stanford University Prof...Related Publications & Presentations 1. Hossam El-Asrag, Heinz Pitsch, Wookyung Kim, Hyungrok Do & M. Godfrey Mungal, Flame Stability in Augmentor...Flows, Comb. Sci. Tech., submitted, 2010. 2. Hossam El-Asrag, Heinz Pitsch, Wookyung Kim, Hyungrok Do & M. Godfrey Mungal, A Computational and

Seeking care as a system.

PubMed

Berwick, Donald M; Luo, Eva

2010-01-01

Kim, aged 3 years, lies asleep, waiting for a miracle. Outside her room, the nurses on the night shift pad softly through the half-lighted corridors, stopping to count breaths, take pulses, or check the intravenous pumps. In the morning, Kim will have her heart fixed. She will be medicated and wheeled into the operating suite. Machines will take on the functions of her body: breathing and circulating blood. The surgeons will place a small patch over a hole within her heart, closing off a shunt between her ventricles that would, if left open, slowly kill her. Kim will be fine if the decision to operate on her was correct; if the surgeon is competent; if that competent surgeon happens to be trained to deal with the particular anatomic wrinkle that is hidden inside Kim's heart; if the blood bank cross-matched her blood accurately and delivered it to the right place; if the blood gas analysis machine works properly and on time; if the suture does not snap; if the plastic tubing of the heart-lung machine does not suddenly spring loose; if the recovery room nurses know that she is allergic to penicillin; if the "oxygen" and "nitrogen" lines in the anesthesia machine have not been reversed by mistake; if the sterilizer temperature gauge is calibrated so that the instruments are in fact sterile; if the pharmacy does not mix up two labels; and if when the surgeon says urgently, "Clamp, right now," there is a clamp on the tray. If all goes well, if ten thousand "ifs" go well, then Kim may sing her grandchildren to sleep some day. If not, she will be dead by noon tomorrow. If Kim were an astronaut, strapped into her seat at the top of some throbbing rocket, the crowd assembled would hold their breath in the morning Florida sun. "How can it possibly work?" they would whisper. "How many parts are there in that machine? A million? What if one fails? My toaster fails. Please let it all work right." The machine would bellow smoke, the gantry fall away, and slowly the monster would

Pressure-induced Formation of Energetic and Structural Extended Solids with Quench-recovery to Ambient Conditions

DTIC Science & Technology

2014-06-12

Duck Young Kim. Synthesis of Mg2C: A Magnesium Methanide, Angewandte Chemie International Edition, (08 2013): 0. doi: 10.1002/anie.201303463 TOTAL...Polymorph of2 Magnesium Sesquicarbide, Inorganic Chemistry (02 2014) DuckYoung Kim, Stevce Stefanoski, Oleksandr O. Kurakevych, Timothy A. Strobel...new phase was discovered in the Li+C system. Figure 6 shows x‐ray diffraction and Raman spectra obtained from this phase, which cannot be

Preemptive Approach to Improving Survival in Epithelial Ovarian Cancer

DTIC Science & Technology

2012-06-01

Metab 2008;93:3471–7. 692[87] Cho JH, Lee JG, Yang YI, Kim JH, Ahn JH, Baek NI, Lee KT, Choi JH. Eupatilin, a die- 693tary flavonoid , induces G2/M cell...Metab 2008;93:3471–7. 692[87] Cho JH, Lee JG, Yang YI, Kim JH, Ahn JH, Baek NI, Lee KT, Choi JH. Eupatilin, a die- 693tary flavonoid , induces G2/M

Estimation of Ocean and Seabed Parameters and Processes Using Low Frequency Acoustic Signals

DTIC Science & Technology

2011-09-01

Dr. Mohsen Badiey (University of Delaware), Kevin Smith (Naval Postgraduate School), Dr. James F. Lynch and Dr. Y.-T. Lin (Woods Hole Oceanographic...Wilson (ARL, University of Texas) in this topic. 3. Finite Element Modeling of wave propagation: Doctoral student, Hui- Kwan Kim, is modeling wave...student Hui- Kwan Kim is focusing on finite element modeling of wave propagation. RESULTS 1. Acoustic variability in the presence of internal waves

JPRS Report, East Asia, Korea: KULLOJA, No. 2, February 1990

DTIC Science & Technology

1990-10-19

translated.] Editorial On Eradication of Bureaucratism [ Kim Il-song] 1 Political and Ideological Let Us Give Full Play to the Revolutionary Spirit...Radical Turn in Mass Guidance—On the 30th Anniversary of the founding of the Chongsan-ri Spirit, Chongsan-ri Method [Kye Ung -tae; not translated...Structures of the WPK Era [ Kim Tae-ho; not translated] 7 Enhancement of Indoctrination in Class Character Is an Important Requirement for

JPRS Report, East Asia Southeast Asia People’s Republic of Kampuchea: Biographic Information on Officials

DTIC Science & Technology

1989-03-30

Revolutionary Committee; see KIM SANGKUM; candidate in May 81 general elections; secretary of Kompong Som municipal provisional party committee (SPK... UNG SAMI (Mar 87); deputy defense minister & chief of KPRAF General Staff replacing KOY BUNTHA (Dec 86); member of KPRP CC, deputy defense...Phnom Penh Military Command (SPK Mar 86); see VEN KAROM. KIM HAK Chairman of Phnom Penh District People’s Revolutionary Committee (Oct 80); see MAU

Effective Dose of Positioning Scans for Five CBCT Devices

DTIC Science & Technology

2016-05-25

CBCT. Journal of Dental Research , Dental Clinics , Dental Prospects 2014;8(2):107-10. 26. Kim D, Rashsuren O, Kim E. Conversion coefficients for the... International Journal of Oral & Maxillofacial Implants 2014;29:55-77. 10. Brooks SL. Radiation doses of common dental radiographic examinations: A review...dose was measured with metal–oxide–semiconductor field-effect transistor (MOSFET) dosimeters for five CBCT devices in a postgraduate dental clinic

Effects of Military Development on Economic Growth in North and South Korea, 1945-1980.

DTIC Science & Technology

1981-12-01

Khruschev’s de -Stalinization campaign and peaceful coexistence policy, coupled with China’s increasing economic and military strength, influenced North Korea...Soviet-North Korean relations. Khruschev’s de -Stalinization policy was considered an attack against any personality cult--which put Kim and Mao under...attack. Kim II-sung’s refusal to accept de -Stalinization, and his pursuit of an independent political course severely strained Soviet- lorth Korean

Urinary biomarkers predict advanced acute kidney injury after cardiovascular surgery.

PubMed

Wang, Jian-Jhong; Chi, Nai-Hsin; Huang, Tao-Min; Connolly, Rory; Chen, Liang Wen; Chueh, Shih-Chieh Jeff; Kan, Wei-Chih; Lai, Chih-Cheng; Wu, Vin-Cent; Fang, Ji-Tseng; Chu, Tzong-Shinn; Wu, Kwan-Dun

2018-04-26

Acute kidney injury (AKI) after cardiovascular surgery is a serious complication. Little is known about the ability of novel biomarkers in combination with clinical risk scores for prediction of advanced AKI. In this prospectively conducted multicenter study, urine samples were collected from 149 adults at 0, 3, 6, 12 and 24 h after cardiovascular surgery. We measured urinary hemojuvelin (uHJV), kidney injury molecule-1 (uKIM-1), neutrophil gelatinase-associated lipocalin (uNGAL), α-glutathione S-transferase (uα-GST) and π-glutathione S-transferase (uπ-GST). The primary outcome was advanced AKI, under the definition of Kidney Disease: Improving Global Outcomes (KDIGO) stage 2, 3 and composite outcomes were KDIGO stage 2, 3 or 90-day mortality after hospital discharge. Patients with advanced AKI had significantly higher levels of uHJV and uKIM-1 at 3, 6 and 12 h after surgery. When normalized by urinary creatinine level, uKIM-1 in combination with uHJV at 3 h post-surgery had a high predictive ability for advanced AKI and composite outcome (AUC = 0.898 and 0.905, respectively). The combination of this biomarker panel (normalized uKIM-1, uHJV at 3 h post-operation) and Liano's score was superior in predicting advanced AKI (AUC = 0.931, category-free net reclassification improvement of 1.149, and p <  0.001). When added to Liano's score, normalized uHJV and uKIM-1 levels at 3 h after cardiovascular surgery enhanced the identification of patients at higher risk of progression to advanced AKI and composite outcomes.

Storage Time and Urine Biomarker Levels in the ASSESS-AKI Study.

PubMed

Liu, Kathleen D; Siew, Edward D; Reeves, W Brian; Himmelfarb, Jonathan; Go, Alan S; Hsu, Chi-Yuan; Bennett, Michael R; Devarajan, Prasad; Ikizler, T Alp; Kaufman, James S; Kimmel, Paul L; Chinchilli, Vernon M; Parikh, Chirag R

2016-01-01

Although stored urine samples are often used in biomarker studies focused on acute and chronic kidney disease, how storage time impacts biomarker levels is not well understood. 866 subjects enrolled in the NIDDK-sponsored ASsessment, Serial Evaluation, and Subsequent Sequelae in Acute Kidney Injury (ASSESS-AKI) Study were included. Samples were processed under standard conditions and stored at -70°C until analyzed. Kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), interleukin-18 (IL-18), and liver fatty acid binding protein (L-FABP) were measured in urine samples collected during the index hospitalization or an outpatient visit 3 months later. Mixed effects models were used to determine the effect of storage time on biomarker levels and stratified by visit. Median storage was 17.8 months (25-75% IQR 10.6-23.7) for samples from the index hospitalization and 14.6 months (IQR 7.3-20.4) for outpatient samples. In the mixed effects models, the only significant association between storage time and biomarker concentration was for KIM-1 in outpatient samples, where each month of storage was associated with a 1.7% decrease (95% CI -3% to -0.3%). There was no relationship between storage time and KIM-1 levels in samples from the index hospitalization. There was no significant impact of storage time over a median of 18 months on urine KIM-1, NGAL, IL-18 or L-FABP in hospitalized samples; a statistically significant effect towards a decrease over time was noted for KIM-1 in outpatient samples. Additional studies are needed to determine whether longer periods of storage at -70°C systematically impact levels of these analytes.

Targeting Murine Mesenchymal Stem Cells to Kidney Injury Molecule‐1 Improves Their Therapeutic Efficacy in Chronic Ischemic Kidney Injury

PubMed Central

Zou, Xiangyu; Jiang, Kai; Puranik, Amrutesh S.; Jordan, Kyra L.; Tang, Hui

2018-01-01

Abstract Mesenchymal stem cells (MSC) have been experimentally used for kidney repair, but modest retention limits their efficacy. Cell‐surface coating allows modulating MSC homing and interaction with target cells. We coated mouse adipose tissue‐derived MSC with antibodies directed against kidney injury molecule‐1 (ab‐KIM1), which is upregulated in injured kidneys, and tested the hypothesis that this would enhance their therapeutic effects in ischemic kidney injury. Untreated MSC, ab‐KIM1‐coated MSC (KIM‐MSC), or vehicle, were injected systemically into the carotid artery of 2‐kidneys, 1‐clip mice 2 weeks after surgery. MSC retention in different organs was explored 24 hours, 48 hours, or 2 weeks after injection. Renal volume, perfusion, and oxygenation were studied 2 weeks after injection using magnetic resonance imaging in vivo, and renal inflammation, apoptosis, capillary density, and fibrosis ex vivo. The ab‐KIM1 coating had little effect on MSC viability or proliferation. The stenotic kidney showed upregulated KIM1 expression, selective homing, and greater retention of KIM‐MSC compared to untreated MSC and compared to other organs. KIM‐MSC‐injected mice improved renal perfusion and capillary density, and attenuated oxidative damage, apoptosis, and fibrosis compared to mice treated with vehicle or with native MSC. In conclusion, MSC coating with ab‐KIM1 increased their retention in the ischemic kidney and enhanced their therapeutic efficacy. This novel method may be useful to selectively target injured kidneys, and supports further development of strategies to enhance cell‐based treatment of ischemic kidney injury. Stem Cells Translational Medicine 2018;7:394–403 PMID:29446551

Experimental verification and comparison of the rubber V- belt continuously variable transmission models

NASA Astrophysics Data System (ADS)

Grzegożek, W.; Dobaj, K.; Kot, A.

2016-09-01

The paper includes the analysis of the rubber V-belt cooperation with the CVT transmission pulleys. The analysis of the forces and torques acting in the CVT transmission was conducted basing on calculated characteristics of the centrifugal regulator and the torque regulator. The accurate estimation of the regulator surface curvature allowed for calculation of the relation between the driving wheel axial force, the engine rotational speed and the gear ratio of the CVT transmission. Simplified analytical models of the rubber V-belt- pulley cooperation are based on three basic approaches. The Dittrich model assumes two contact regions on the driven and driving wheel. The Kim-Kim model considers, in addition to the previous model, also the radial friction. The radial friction results in the lack of the developed friction area on the driving pulley. The third approach, formulated in the Cammalleri model, assumes variable sliding angle along the wrap arch and describes it as a result the belt longitudinal and cross flexibility. Theoretical torque on the driven and driving wheel was calculated on the basis of the known regulators characteristics. The calculated torque was compared to the measured loading torque. The best accordance, referring to the centrifugal regulator range of work, was obtained for the Kim-Kim model.

The Changing Balance: South and North Korean Capabilities for Long-Term Military Competition

DTIC Science & Technology

1985-12-01

econometric model. Ideally, a model should be estimated over one period and then tested over a different period. If one esti- mates and tests over the...unprecedented impending shift of political leadership from Kim II-Sung to his son, Kim Chong-Il. Section III summarizes an aggregative econometric ...model of the South Korean economy, which we have developed to test the effect on that economy of alternative South Korean military force postures and

The Conundrum of Online Prescription Drug Promotion Comment on "Trouble Spots in Online Direct-to-Consumer Prescription Drug Promotion: A Content Analysis of FDA Warning Letters".

PubMed

Wanasika, Isaac

2016-03-26

This commentary discusses pertinent issues from Hyosun Kim's paper on online prescription drug promotion. The study is well-designed and the findings highlight some of the consequences of the Food and Drug Administration's (FDA's) decision to deregulate online advertising of prescription drugs. While Kim's findings confirm some of the early concerns, they also provide a perspective of implementation challenges in the ever-changing technological environment. © 2016 by Kerman University of Medical Sciences.

Identification of Sonic Hedgehog-Induced Stromal Factors That Stimulate Prostate Tumor Growth

DTIC Science & Technology

2007-11-01

Regulates Prostate Tumor Growth by a Paracrine Mechanism. Poster at The 4th International Conference on Tumor Microenvironment, Florence, Italy ...transcription in a prostate smooth muscle cell line (PS-1). Endocrinology 137:864-872. Grishina, I.B., Kim, S.Y., Ferrara , C., Makarenkova, H.P., and Walden...Endocrinology 137:864-872. Grishina, I.B., Kim, S.Y., Ferrara , C., Makarenkova, H.P., and Walden, P.D. (2005) BMP7 inhibits branching morphogenesis in the

Comment on "Unification of multiqubit polygamy inequalities"

NASA Astrophysics Data System (ADS)

Song, Wei; Zhao, Jun-Long; Yu, Long-Bao; Zhang, Li-Hua

2017-05-01

Recently, Kim established a unified view of polygamy of multiqubit entanglement [Phys. Rev. A 85, 032335 (2012), 10.1103/PhysRevA.85.032335]. In order to prove their main results, Kim first proposed an important property which is illustrated in Lemma 2. We point out that his proofs of Lemma 2 are flawed because of some errors in his derivations. Furthermore, we present an improved method to prove the original results.

Physics-Based Modeling and Measurement of High-Flux Condensation Heat Transfer

DTIC Science & Technology

2011-09-01

TRANSFER (Contract No. N000140811139) by Prof. Issam Mudawar Sung-Min Kim Joseph Kim Boiling and Two-Phase Flow Laboratory School of...Final 01-10-2008 to 30-09-2011 Physics-Based Modeling and Measurement of High-Flux Condensation Heat Transfer NA N00014-08-1-1139 NA NA NA NA Mudawar ...respectively. phase change, condensation, electronics cooling, micro-channel, high-flux U U U UU 107 Mudawar , Issam 765-494-5705 Reset PHYSICS-BASED

Development and Translation of a Tissue-Engineered Disc in a Preclinical Rodent Model

DTIC Science & Technology

2013-10-01

authors Dong Hwa Kim, John T. Martin, Dawn M. Elliott, Lachlan J. Smith , and Robert L. Mauck...Replacement in a Small Animal Model with authors John T. Martin, Andrew H. Milby, Joseph A. Chiaro, Dong Hwa Kim, Nader M. Hebela, Lachlan J. Smith , Dawn... Smith , Dawn M. Elliott, and Robert L. Mauck is now in review. To carry out this study, radiopaque scaffolds were generated from a 14.3% w/v slurry

Temporal Behavior of the Intensity-Dependent Absorption in Photorefractive BaTiO3

DTIC Science & Technology

1988-06-01

George Brost , and Jim Rotg6 JUL o 8 88 i’rinh I S", h’r i.seuu,:h .Labor(mfries, I S Air For, Acudeu\\. (olorudo (180840 0) Jin J. Kim (n ’r for If0gh / whu...Phys. 59, 3363 (1986). that these observations can be explained by a multi- 6. G. A. Brost . R. A. Motes, J. R. Rotg , and J1. J. Kim, in pie-trap model

Translations on North Korea, Number 518.

DTIC Science & Technology

1977-04-05

Populace To Assure Self-Defense (Yi Ung -kyu; MINJU CHOSON, 14 Jan 77) 13 Seoul Paper Comments on DPRK Defector ’s Revelations (Editorial; THE...56 Agricultural Meeting 57 Korean-Malagasy Association 57 Railroad Transportation 57 Kim Il-song Work Published 57 Women’s Union Session 58 Rail...Marshal Kim Il-song and the energetic guidance of the glorious Party Center our people and youths are furiously engaging in the Campaign to Capture

Thermal Decomposition Mechanism of 1-ethyl-3-methylimidazolium Bromide Ionic Liquid (Preprint)

DTIC Science & Technology

2011-09-14

TetraethylammoniumTrifluoromentanesulfonate Ionic Liquid and Neutralized Nafion 117 for High-Temperature Fuel Cells J. Am. Chem. Soc. 2010, 132, 2183-2195. (7) Kim, S. Y.; Kim, S...bromide 5b. GRANT NUMBER ionic liquid (Preprint) 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Steven D. Chambreau, Jerry A. Boatz, Ghanshyam L. Vaaghjiani...In order to better understand the volatilization process for ionic liquids , the vapor evolved from heating the ionic liquid 1-ethyl-3

Development of N- and P- Types of Semiconducting Polymers

DTIC Science & Technology

2015-03-05

Luyao Lu, Tao Xu, Ju Min Lee, Zhiqiang Luo, Feng He, Hyung Il Park, In Hwan Jung, Sang Ouk Kim, Luping Yu, “The Role of N- Doped Multi-wall Carbon...Luping Yu, Di-Jia Liu, Improving Hydrogen Adsorption Enthalpy Through Coordinatively 23 Unsaturated Cobalt in Porous Polymers, Macromolecular...Sang Ouk Kim, Luping Yu, “The Role of N- Doped Multi-wall Carbon Nanotubes in Achieving Highly Efficient Polymer Bulk Heterojunction Solar Cells

The Hygiene Hypothesis and Breast Cancer a Novel Application of an Etiologic Theory for Allergies, Asthma, and Other Immune Disorders

DTIC Science & Technology

2007-05-01

REFERENCE YEAR-2] and [REFERENCE YEAR], on average, how many days per month did you eat the following kinds of foods: Q68. Yogurt (not the frozen...kind)? days/month Q69. Kim chee or sauerkraut ( fermented cabbage) days/month Q70. Lactobacillus or probiotic supplements...entre [AÑO DE REFERENCIA-2] y [AÑO DE REFERENCIA]: Q68. Yogurt (no del tipo congelado)? días / mes Q69. Kim chee o chukrut (repollo

The Nation That Cried Lone Wolf: A Data-Driven Analysis of Individual Terrorists in the United States Since 9/11

DTIC Science & Technology

2012-03-01

the “ Underwear Bomber.” He is not classified as a lone-wolf terrorist, although he did operationalize his attack as a lone individual. Abdulmutallab...commencing the attacks. 4. July 2002—Hesham Mohamed Hadayet Hesham Mohamed Hadayet opened fire in Los Angeles International Airport on July 4, 2002...killed Hadayet at the scene. 76 5. October 2002—Steve Kim Postal worker Steve Kim fired seven shots at the United Nations to physically protest

Alliance or Reliance? Reconsidering U.S. Forces in the Republic of Korea

DTIC Science & Technology

2012-05-17

Council of Northern California, 1988), 2. 29 Robert J. Pauly , The Ashgate Research Companion to US Foreign Policy (Farnham, England; Burlington, Vt...commerce between the two countries. Presidents Kim Dae- jung (1998-2003) and Roh Moo-hyun (2003-2008) embraced this policy as a cost-effective means to...6, 2011." 30 “enemy” as the Americans view the north. President Kim Dae- jung expressed these sentiments after a North-South summit meeting in

Groupthink: A Significant Threat to the Homeland Security of the United States

DTIC Science & Technology

2014-12-01

Jin Nam Choi and Myung Un Kim, details a study that examines groupthink’s effect on 30 organizational teams faced with impending crises. The study...40sessionmgr114&hid=115. 13 Jin Nam Choi and Myung Un Kim, “The Organizational Application of Groupthink and its Limitations in Organizations,” Journal of...the past to provide a mechanism that will help identify, manage, and mitigate this psychological phenomenon in the homeland security enterprise

The relationship between passibility, agency and social interaction and its relevance for research and pedagogy

NASA Astrophysics Data System (ADS)

Kirch, Susan A.; Ma, Jasmine Y.

2016-12-01

The interaction analysis presented by Kim and Roth examines nine students, their teachers, the learning task and materials in a mixed second and third grade science classroom during the school day. In the research narrative readers are introduced to two resourceful and creative groups of students as they work on a task assigned by their teacher—to cantilever a pizza box over the edge of a student desk. Readers are given glimpses (through images and transcripts) of the inventive ways each group solved the cantilever problem. Sometimes the children disregarded the design constraints, but even after compliance they managed to successfully solve the problem. The point of the learning task was not clearly stated, but readers are told the unit focused on investigating forces, forces in equilibrium, and structures as well as different forces (push, pull, etc.), properties of materials, and the relations between weight and balance while building structures. Kim and Roth were specifically interested in using this session to investigate and resolve the problem of learning as described by socio-cultural theorists as, how does a learner orient toward a learning outcome when they cannot do that until they have learned it? To answer this question Kim and Roth argued that learners (in engineering design) learn when and because: (1) they are open to be affected by the responses of materials to student action (i.e. student and material agency and physical touch) (2) their bodies are endowed with the capacity to be affected (i.e. passibility), and (3) knowledge and understanding emerge as and in social relations first. In their analysis, Kim and Roth argued that knowledge and knowing-how depend on these three universal processes. The authors further theorized the concept of passibility. Included in their theory of passibility was the claim that passibility is necessary for agency. After reading this paper we found we had many questions about Kim and Roth's analysis, context, and

Preclinical evaluation of novel urinary biomarkers of cadmium nephrotoxicity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Prozialeck, Walter C.; Edwards, Joshua R.; Vaidya, Vishal S.

2009-08-01

As a result of the widespread use of Cd in industry and its extensive dissemination in the environment, there has been considerable interest in the identification of early biomarkers of Cd-induced kidney injury. Kim-1 is a transmembrane glycoprotein that is not detectable in normal kidney, but is up-regulated and shed into the urine following ischemic or nephrotoxic injury. Recent studies utilizing a sub-chronic model of Cd exposure in the rat have shown that Kim-1 is an early urinary marker of Cd-induced kidney injury. Kim-1 was detected in the urine 4-5 weeks before the onset of proteinuria and 1-3 weeks beforemore » the appearance of urinary metallothionein and Clara cell protein 16, which are standard markers of Cd nephrotoxicity. In the present study, we have compared the time course for the appearance of Kim-1 in the urine with the time course for the appearance of alpha glutathione-S-transferase ({alpha}-GST), N-acetyl-{beta}-D-glucose amidase (NAG) and Cd, each of which have been used or proposed as urinary markers of Cd nephrotoxicity. Adult male Sprague-Dawley rats were given daily subcutaneous injections of 0.6 mg (5.36 {mu}moles)/kg Cd, 5 days per week for up to 12 weeks. One day each week, 24 h urine samples were collected and analyzed for protein, creatinine and the various markers. The results showed that significant levels of Kim-1 appeared in the urine as early as 6 weeks into the treatment protocol and then continued to rise for the remainder of the 12 week treatment period. By contrast, significant levels of {alpha}-GST and NAG did not appear in the urine until 8 and 12 weeks, respectively, while proteinuria was not evident until 10 weeks. The urinary excretion of Cd was below the level of detection until week 4 and then showed a slow, linear increase over the next 6 weeks before increasing markedly between weeks 10 and 12. These results provide additional evidence that Kim-1 is a sensitive biomarker of the early stages of Cd-induced proximal

Interactive and Continuous Collision Detection for Avatars in Virtual Environments

DTIC Science & Technology

2007-01-01

Box 12211 Research Triangle Park, NC 27709-2211 15. SUBJECT TERMS collision detection Young Kim, Stephane Redon, Ming Lin, Dinesh Manocha, Jim...Redon1 Young J. Kim2 Ming C. Lin1 Dinesh Manocha1 Jim Templeman3 1 University of North Carolina at Chapel Hill 2 Ewha University, Korea 3 Naval...An offset spline approximation for plane cubic splines. Computer-Aided Design, 15(5):297– 299, 1983. [20] S. Kumar and D. Manocha. Efficient

North Korean Policy Elites

DTIC Science & Technology

2004-06-01

far the largest and covers almost the entire nation. Its programming includes news, educational, and entertainment shows; however, it mimics the print...Kim Chong-il, Head, Cadres of 5th Section (Female Entertainers ) Yi Myong-che Secretary to Kim Chong-il. Provides policy recommendations and oversees...for his table to Japanese jet skis and Sony home electronics.9 Likewise, the account of Yi Nam-oak (Li Nam-ok), who grew up as a companion to Kim’s

Novel Low Cost High Efficiency Tunable RF Devices and Antenna Arrays Design based on the Ferroelectric Materials and the CTS Technologies

DTIC Science & Technology

2011-02-14

licensed use limited to: UNIV OF HAWAII LIBRARY. Downloaded on June 18,2010 at 22:24:49 UTC from IEEE Xplore . Restrictions apply. KIM et al.: MODIFIED...limited to: UNIV OF HAWAII LIBRARY. Downloaded on June 18,2010 at 22:24:49 UTC from IEEE Xplore . Restrictions apply. 404 IEEE TRANSACTIONS ON...licensed use limited to: UNIV OF HAWAII LIBRARY. Downloaded on June 18,2010 at 22:24:49 UTC from IEEE Xplore . Restrictions apply. KIM et al

A Study on the Perceptions About Potential Advantages of FMS (Foreign Military Sales) and Commercial Sales: Seller and Buyer Perspectives

DTIC Science & Technology

1987-09-01

SFl WILE coP DTIC ELECTEI DEC0 419871 OFD IIN A STUDY ON THE PERCEPTIONS ABOUT COMMERCIAL SALES: SELLER ANDI • BUYER PERSPECTIVES THESIS Yong Sang Kim...PERCEPTIONS ABOUT H𔃾 POTENTIAL ADVANTAGES OF FMS AND COMMERCIAL SALES: SELLER AND BUYER PERSPECTIVES THESIS Accession For Yong Sang Kim NTIS ,RA&I Major...AND COMMERCIAL SALES: SELLER AND BUYER PERSPECTIVES THESIS Presented to the Faculty of the School of Systems and Logistics of the Air Force Institute

Understanding and Quantifying the Reactivity of Energetic NanoParticles and NanoComposites

DTIC Science & Technology

2010-08-30

K. J.; Jung , H. J.; Kittelson, D. B.; Roberts, J. T.; Zachariah, M. R. Journal of Physical Chemistry A 2002, 106, 96. (37) Kim, S. H.; Fletcher, R...43) Kim, S. H.; Zachariah, M. R. Journal of Physical Chemistry B 2006, 110, 4555. (44) Higgins, K. J.; Jung , H. J.; Kittelson, D. B.; Roberts...Measurement of airborne particles, 2 ed.; John Wiley & Sons, Inc.: New York, NY, 1999. (46) Jung , H.; Kittelson, D. B.; Zachariah, M. R. Combustion and

Deterrence and Engagement: U.S. and North Korean Interactions over Nuclear Weapons since the End of the Cold War

DTIC Science & Technology

2008-12-01

Self-help,” International Security 19, no. 3 (Winter 1994-1995). 86 Bruce Auster and Kevin Whitelaw, “Upping the ante for Kim Jong Il: Pentagon Plan...and Kevin O’Neil, Solving the North Korean Nuclear Puzzle (Washington, D.C.: Institute for Science and International Security Press, 2002), 57-82...Minister Kim Gye Kwan “angrily denied that the DPRK had an HEU program. He dismissed my statement, claiming it was a fabrication.”234 And then, in the

Translations on North Korea. Number 534

DTIC Science & Technology

1977-06-13

May 77)... Nature Remaking Work Needed To Occupy Food Grain Height ( Kim Il-song; ALGOK 1,000 MAN TON KOJIRUL CHOMNYONG HAGI WIHAN CHAYON KAEJO...meeting, Choe Yong -kun extended, on the occasion of the "week of support to the struggle of the Palestine people," warm congratu- lations and militant...people. Present at the meeting were Kim Kuk-hun, Yi Chong-mok, and other personages concerned, and working people in the city. Diplomatic envoys of

C12A7 Electride Hollow Cathode

DTIC Science & Technology

2013-03-01

due to its unique charged lattice structure (Kim, Toda , et al, 2006) (Medvedeva, Teasley, & Hoffman, 2007) ( Toda , et al., 2004). If the 0.6 eV work...formation of the lattice, which then evacuate upon cooling leaving behind their electrons (Kim, Toda , et al, 2006).     Figure 1: Structure of C12A7...electride in which an electron is clathrated within the positively charged lattice framework ( Toda , et al., 2007). Distribution A: Approved for

Topological Weyl semimetals in Bi1 -xSbx alloys

NASA Astrophysics Data System (ADS)

Su, Yu-Hsin; Shi, Wujun; Felser, Claudia; Sun, Yan

2018-04-01

We investigated Weyl semimetal (WSM) phases in bismuth antimony (Bi1 -xSbx ) alloys by combination of atomic composition and arrangement. Via first-principles calculations, we found two WSM states with Sb concentrations of x =0.5 and 0.83 with specific inversion-symmetry-broken elemental arrangement. The Weyl points are close to the Fermi level in both of these two WSM states. Therefore, it is likely to obtain Weyl points in Bi-Sb alloy. The WSM phase provides a reasonable explanation for the current transport study of Bi-Sb alloy with the violation of Ohm's law [D. Shin, Y. Lee, M. Sasaki, Y. H. Jeong, F. Weickert, J. B. Betts, H.-J. Kim, K.-S. Kim, and J. Kim, Nat. Mater. 16, 1096 (2017), 10.1038/nmat4965]. This paper shows that the topological phases in Bi-Sb alloys depend on both elemental composition and their specific arrangement.

Urinary levels of novel kidney biomarkers and risk of true worsening renal function and mortality in patients with acute heart failure.

PubMed

Sokolski, Mateusz; Zymliński, Robert; Biegus, Jan; Siwołowski, Paweł; Nawrocka-Millward, Sylwia; Todd, John; Yerramilli, Malli Rama; Estis, Joel; Jankowska, Ewa Anita; Banasiak, Waldemar; Ponikowski, Piotr

2017-06-01

Recent studies indicate the need to redefine worsening renal function (WRF) in acute heart failure (AHF), linking a rise in creatinine with clinical status to identify patients who develop 'true WRF'. We evaluated the usefulness of serial assessment of urinary levels of neutrophil gelatinase-associated lipocalin (uNGAL), kidney injury molecule-1 (uKIM-1), and cystatin C (uCysC) for prediction of 'true WRF'. In 132 patients with AHF, uNGAL, uKIM-1, and uCysC were measured using a highly sensitive immunoassay based on a single-molecule counting technology (Singulex, Alameda, CA, USA) at baseline, day 2, and day 3. Patients who developed WRF (a ≥0.3 mg/dL increase in serum creatinine or a >25% decrease in the estimated glomerular filtration rate from the baseline value) were differentiated into those 'true WRF' (presence of deterioration/no improvement in clinical status during hospitalization) vs. 'pseudo-WRF' (uneventful clinical course). 'True WRF' occurred in 13 (10%), 'pseudo-WRF' in 15 (11%), whereas the remaining 104 (79%) patients did not develop WRF. Patients with 'true WRF' were more often females, had higher levels of NT-proBNP, creatinine, and urea on admission, higher urine albumin to creatinine ratio at day 2, higher uNGAL at baseline, day 2, and day 3, and higher KIM-1 at day 2 (vs. pseudo-WRF vs. without WRF, all P < 0.05). Patients with pseudo-WRF did not differ from those without WRF. In the multivariable model, elevated uNGAL at all time points and uKIM-1 at day 2 remained independent predictors of 'true WRF'. Elevated levels of uNGAL and uKIM-1 may predict development of 'true WRF' in AHF. © 2017 The Authors. European Journal of Heart Failure © 2017 European Society of Cardiology.

Storage Time and Urine Biomarker Levels in the ASSESS-AKI Study

PubMed Central

Liu, Kathleen D.; Siew, Edward D.; Reeves, W. Brian; Himmelfarb, Jonathan; Go, Alan S.; Hsu, Chi-yuan; Bennett, Michael R.; Devarajan, Prasad; Ikizler, T. Alp; Kaufman, James S.; Kimmel, Paul L.; Chinchilli, Vernon M.; Parikh, Chirag R.

2016-01-01

Background Although stored urine samples are often used in biomarker studies focused on acute and chronic kidney disease, how storage time impacts biomarker levels is not well understood. Methods 866 subjects enrolled in the NIDDK-sponsored ASsessment, Serial Evaluation, and Subsequent Sequelae in Acute Kidney Injury (ASSESS-AKI) Study were included. Samples were processed under standard conditions and stored at -70°C until analyzed. Kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), interleukin-18 (IL-18), and liver fatty acid binding protein (L-FABP) were measured in urine samples collected during the index hospitalization or an outpatient visit 3 months later. Mixed effects models were used to determine the effect of storage time on biomarker levels and stratified by visit. Results Median storage was 17.8 months (25–75% IQR 10.6–23.7) for samples from the index hospitalization and 14.6 months (IQR 7.3–20.4) for outpatient samples. In the mixed effects models, the only significant association between storage time and biomarker concentration was for KIM-1 in outpatient samples, where each month of storage was associated with a 1.7% decrease (95% CI -3% to -0.3%). There was no relationship between storage time and KIM-1 levels in samples from the index hospitalization. Conclusion There was no significant impact of storage time over a median of 18 months on urine KIM-1, NGAL, IL-18 or L-FABP in hospitalized samples; a statistically significant effect towards a decrease over time was noted for KIM-1 in outpatient samples. Additional studies are needed to determine whether longer periods of storage at -70°C systematically impact levels of these analytes. PMID:27788160

The prediction of total skeletal muscle mass in a Caucasian population - comparison of Magnetic resonance imaging (MRI) and Dual-energy X-ray absorptiometry (DXA).

PubMed

Geisler, Corinna; Pourhassan, Maryam; Braun, Wiebke; Schweitzer, Lisa; Müller, Manfred J

2017-03-01

Dual-energy X-ray (DXA) is an alternative to magnetic resonance imaging (MRI) to measure skeletal muscle mass. DXA assesses lean body mass (LBM), and MRI measures skeletal muscle mass (SMM). Kim et al. (Am J Clin Nutr 2002; 76: 378; J Appl Physiol (1985) 2004; 97: 655) developed MRI-based algorithms to estimate whole-body SMM by DXA. These algorithms were based on an ethnically mixed study population (Kim et al., Am J Clin Nutr 2002; 76: 378; J Appl Physiol (1985) 2004; 97: 655). It is unclear whether Kim's algorithms are accurate in an exclusive Caucasian population. The aim of our study was to validate Kim's equation in a Caucasian population of 346 subjects. SMM MRI was assessed using MRI, and LBM and BMC DXA were measured by DXA and fat mass (FM ADP ) by air-displacement plethysmographie (ADP). SMM MRI and predicted SMM were highly correlated (r = 0·944; P<0·05). The standard error of estimate of the regression equation was 2·4 kg. However, Bland-Altman plots showed a significant (P<0·001) systematic bias between SMM MRI (median 25·1 kg; IQ 20·2-31·1 kg) and predicted SMM (median 26·3 kg; IQ 22·6-33·0 kg), overestimating SMM by 9·8%. Multiple regression analyses showed that weight explained 4·4% of the variance in the differences between SMM MRI and predicted SMM with the major part unexplained. Kim's algorithm has a systematic unexplained bias and is not recommended in Caucasians. © 2015 Scandinavian Society of Clinical Physiology and Nuclear Medicine. Published by John Wiley & Sons Ltd.

Serum Neutrophil Gelatinase-Associated Lipocalin and Urinary Kidney Injury Molecule-1 as Potential Biomarkers of Subclinical Nephrotoxicity After Gadolinium-Based and Iodinated-Based Contrast Media Exposure in Pediatric Patients with Normal Kidney Function

PubMed Central

Spasojević-Dimitrijeva, Brankica; Kotur-Stevuljević, Jelena; Đukić, Milan; Paripović, Dušan; Miloševski-Lomić, Gordana; Spasojević-Kalimanovska, Vesna; Pavićević, Polina; Mitrović, Jadranka; Kostić, Mirjana

2017-01-01

Background New renal biomarkers such as neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) show promise in early diagnosis of contrast media induced acute kidney injury (CI-AKI). The purpose of our study was to compare the subclinical nephrotoxicity (a condition without changes in standard renal biomarkers) of gadolinium-based contrast media (Gd-DTPA, gadopentetate dimeglumine) and iodinated-based contrast media (iopromide) in pediatric patients with normal kidney function. Material/Methods The first group (n=58) of patients included in the study were undergoing angiography with iopromide, and the second group (n=65) were undergoing magnetic resonance (MR) angiography/urography with Gd-DTPA administration. The concentrations of NGAL and KIM-1 were measured four times in the urine (pre-contrast, then at four hours, 24 hours, and 48 hours after contrast administration), and serum NGAL was measured at 0 (baseline), 24 hours, and 48 hours after contrast exposure. Results After 24 hours, serum NGAL increase of ≥25% was noticed in 32.6% of the patients in the iopromide group and in 25.45% of the patients in the gadolinium group, with significantly higher average percent of this increase in first group (62.23% vs. 36.44%, p=0.002). In the Gd-DTPA group, we observed a statistically significant increase in urinary KIM-1 24 hours after the procedure. Normalized urinary KIM-1, 24 hours after contrast exposure, was a better predictive factor for CI-AKI than other biomarkers (AUC 0.757, cut off 214 pg/mg, sensitivity 83.3%, specificity 54.2%, p=0.035). Conclusions In children with normal renal function, exposure to iodinated-based and gadolinium-based media might lead to subclinical nephrotoxicity, which could be detected using serum NGAL and urinary KIM-1. PMID:28874655

Treating Suicidal Behavior in the Mentally Retarded: The Case of Kim.

ERIC Educational Resources Information Center

Berman, Alan L., Ed.; And Others

1992-01-01

Presents case study of 36-year-old mildly retarded white woman who lived in group home and who recently tried to injure herself. Comments on the case and on interventions are given by Rowland Barrett and Anne Walters from Brown University School of Medicine, Emma Pendleton Bradley Hospital and from Howard Pressman, in independent practice in…

Characterization and Targeting of the Aldehyde Dehydrogenase Subpopulation in Ovarian Cancer

DTIC Science & Technology

2014-07-01

Secondary Cytoreduction for Recurrent Ovarian Cancer. Int J Gyn Cancer, 21(5): 831- 6, 2011. PMID: 21613957 3. Nick AM, Stone RL, Armaiz-Pena G...Ozpolat B, Tekederli I, Graybill WS, Landen CN, Villares G, Vivas-Mejia P, Bottsford-Miller J , Kim HS, Lee JS, Kim SM, Baggerly KA, Ram PT, Deavers MT...Coleman RL, Lopez-Berestein G, Sood AK. Silencing of p130cas in Ovarian Carcinoma: A Novel Mechanism for Tumor Cell Death. J Natl Cancer Inst, 103

North Korean Foreign Relations in the Post-Cold War World

DTIC Science & Technology

2007-04-01

Intentions, written Dr. Scobell, was pub- lished in July 2005. The second monograph, Kim Jong Il and North Korea: The Leader and the System , also writ... system to that of an aggressive nation representing a mortal threat. As if in fear of the DPRK’s “tyranny of proximity,” however, all three of North...fu- ture of the post–Kim Il Sung system opens up room for the outside world to use whatever leverage it might have to nudge North Korean leaders

Genome-Wide Association Study in African-Americans with Systemic Lupus Erythematosus

DTIC Science & Technology

2012-09-01

variety of settings. Our control data were used in a study of sarcoidosis (2), showing how the data collected for one project can be a benefit in another...ethnic specific Loci in sarcoidosis susceptibility, PLoS One 7, e43907. PMCID: PMC3428296. 2. Anaya JM, Kim-Howard X, Prahalad S, Chernavsky A, Canas C...Loci in sarcoidosis susceptibility, PLoS One 7, e43907. PMCID: PMC3428296. 5 3. Anaya JM, Kim-Howard X, Prahalad S, Chernavsky A, Canas C, Rojas

Physical Processes in Hollow Cathode Discharge

DTIC Science & Technology

1989-12-01

State University. Finally, many thanks to my wife, Kyoung -Sook and my son, Frederick Teut, for their love and being supportive for two and half years...recommended for all electron emission purposes. 46 REFERENCES 1. Kim Gunther, "Hollow Cathode Plasma Source" ( Spectra-Mat Hollow Cathode Manual...59 Dong 401 Ho Seoul, Republic of Korea 8. Maj. Kim , Jong-Ryul 1 Postal Code 500-00 Book-Gu, Du-Am Dong, 874-14 Kwang-Ju, Republic of Korea 9. Maj

A Retrospective Analysis of the Carter Koreanization Plan: A Case Study of a Blurred Vision

DTIC Science & Technology

1992-04-06

SS WD 0 A otrnD V19S9O WMAM Lietennt oloelHowrd .LIMEia Unte tae Am Best Available Copy UNCLASSIFIED SECURITY CLASSIFICATION OF THIS PAGE REPORT...long-standing, overriding aims of Kim Il Sung, the capricious and bellicose leader of the Democratic People’s Republic of Korea (DPRK), has been to...in Northeast Asia in gejneral and, given Kim Il Sung’s belligerence, on South Korean soil in particular. Since the outbreak of the Korean Wa-r the

Characterization of Infrared Properties of Layered Semiconductors.

DTIC Science & Technology

1987-02-20

candidate -10- V. PUBLICATIONS INCLUDED WITH REPORT 1) R. Braunstein, R. K . Kim, D. Matthews, and M. Braunstein: "Derivative Absorption Spectroscopy of...34Wavelength Modulation Spectra of a-Ag0.7Zn0 .3 Near the Optical Absorption Edge," Phys. Stat. Sol.(b) 131, 659 (1983). 5) R. K . Kim and R. Braunstein...34Infrared Wavelength Modulation Spectroscopy of Some Optical Material," Appl. Optics 23(8), 1166 (1984). 6) C.E. Jones, K . James, J. Merz, R. Braunstein, M

Evolution of Cold War Rules of Engagement: The Soviet Combat Role in the Korean War, 1950-1953

DTIC Science & Technology

1993-06-04

the threat to cut off electricity to the South. 1 0 6 With some misgivings, the ele:.’ons were certified as valid by the UN Temporary Commission on...Korea’s renewed threat to cut off electric sup- plies was directed at undercutting Southern moderates, especially Kim Ku and Kim Kyu-sik. They had...then possessed by the State Department - MacArthur saw Soviet fears ’of this new Frankenstein that is being gradually congealed and coalesced in China

Research in Image Understanding as Applied to 3-D Microwave Tomographic Imaging with Near Optical Resolution.

DTIC Science & Technology

1987-03-01

Oct. 1985. 28. D.L. Jaggard, K. Schultz, Y. Kim and P. Frangos , "Inverse Scattering for Dielectric Media", Annual OSA Meeting, Wash. D.C., Oct. 1985...T.H. Chu - Graduate Student (50%) C.Y. Ho - Graduate Student (50%) Y. Kim - Graduate Student (50%) K S. Lee - Graduate Student (50%) P. Frangos ...1982. 3. P. Frangos (Ph.D.) - "One-Dimensional Inverse Scattering: Exact Methods and Applications". 4. C.L. Werner (Ph.D.) - ŗ-D Imaging of Coherent and

The Impact of US Forces in Korea

DTIC Science & Technology

1987-01-01

190-193. 13. Kim Chum, The Korean War, pp. 187-188. 14. Chu Yong -bok, "How Longing," Dong-A Ilbo, July 10, 1952. p. 2. Chu was a former People’s Army...those who provided comments and suggestions were Brigadier General Kim Jung Whan, formerly colonel, Combined Forces Com- mand, ROK/US; Brigadier General...Korean Defense College faculty; and two class- mates at the Korean Military Academy (class of 1965), Colonel Park Yong Ok, of the Korean Defense

Incremental validity of mindfulness skills in relation to emotional dysregulation among a young adult community sample.

PubMed

Vujanovic, Anka A; Bonn-Miller, Marcel O; Bernstein, Amit; McKee, Laura G; Zvolensky, Michael J

2010-01-01

The present investigation examined the incremental predictive validity of mindfulness skills, as measured by the Kentucky Inventory of Mindfulness Skills (KIMS), in relation to multiple facets of emotional dysregulation, as indexed by the Difficulties in Emotion Regulation Scale (DERS), above and beyond variance explained by negative affectivity, anxiety sensitivity, and distress tolerance. Participants were a nonclinical community sample of 193 young adults (106 women, 87 men; M(age) = 23.91 years). The KIMS Accepting without Judgment subscale was incrementally negatively predictive of all facets of emotional dysregulation, as measured by the DERS. Furthermore, KIMS Acting with Awareness was incrementally negatively related to difficulties engaging in goal-directed behavior. Additionally, both observing and describing mindfulness skills were incrementally negatively related to lack of emotional awareness, and describing skills also were incrementally negatively related to lack of emotional clarity. Findings are discussed in relation to advancing scientific understanding of emotional dysregulation from a mindfulness skills-based framework.

Sony’s Nightmare before Christmas: The 2014 North Korean Cyber Attack on Sony and Lessons for US Government Actions in Cyberspace

DTIC Science & Technology

2018-02-01

4,  2014), http://www.businessinsider.com/ experts-the-sony-hack-looks-a-lot-like-previous-attacks-on- south-korea-2014-12. 39 Kim Zetter, “Logic Bomb ...Set Off South Korea Cyberattack,” Wired (March 21, 2013), https://www.wired.com/2013/03/logic- bomb -south-korea-attack/. 40 Brian Krebs, “The Case...Agency (March  21,  2013), http://english.yonhapnews.co.kr/ national/2013/03/21/55/0302000000AEN20130321003552315F. HTML. 47 Kim Zetter, “Logic Bomb

Translations on North Korea, Number 546.

DTIC Science & Technology

1977-08-26

Comrade Ho Tam " Kye Ung -t’ae " Pak Yong -sok Functionary of the sector concerned Yi Ch’ang-son " Chon In-ch’ol " [Pyongyang NODONG SINMUN in Korean 14...functionary of the sector concerned Kim Tu- yong . [Pyongyang NODONG SINMUN in Korean 15 Jun 77 p 2] ARAB DELEGATION WELCOME—The following participated...Hwa-son . Functionary of the sector concerned Kim Yong -sun " [Pyongyang NODONG SINMUN in Korean 15 Jun 77 p 3] ARAB DELEGATION BANQUET—Attending a

Chemical Bonding, Interdiffusion and Electronic Structure at InP, GaAs, and Si-Metal Interfaces.

DTIC Science & Technology

1984-01-15

1980) 420. 37. A. Hiraki , K. Shuts. F. Kim. W. Kammura. and W. Iwami, A\\ppl. Phys. Len. 31 (1977) 611, and references therein. 38. L.J. Brilison, C.F...and references therein. 5. A. Hiraki , M.A. Nicolet, and J.W. Mayer, Appi. Phys. Lett. !a, 178 (1971); A. Hiraki , K. Shuto, F. Kim, W. Kammura, and W...IZ, 1005 (1980) and references therein. 7. T. Narusawa, K. Kinoshita, W.M. Gibson, and A. Hiraki , J. Vac. Sci. Technol.. Ia. 872 (1981). 8. J

Quantum Information Processing with Ferroelectrically Coupled Quantum Dots

DTIC Science & Technology

2010-12-05

on a chip applications. (a) Papers published in peer-reviewed journals (N/A for none) Y. Xi, Y. S. Jung , and H. K. Kim, “Interaction of light with a...metal wedge: the role of diffraction in shaping energy flow”, Optics Express 18, 2588-2600 (2010). Y. S. Jung , J. Wuenschell, H. K. Kim, P. Kaur, and D...H. Waldeck, “Blue-shift of surface plasmon resonance in a metal nanoslit array structure”, Optics Express 17, 16081-16091 (2009). Y. S. Jung , Y. Xi

Potential diagnostic biomarkers for chronic kidney disease of unknown etiology (CKDu) in Sri Lanka: a pilot study.

PubMed

Sayanthooran, Saravanabavan; Magana-Arachchi, Dhammika N; Gunerathne, Lishanthe; Abeysekera, Tilak

2017-01-19

In Sri Lanka, there exists chronic kidney disease of both known (CKD) and unknown etiologies (CKDu). Identification of novel biomarkers that are customized to the specific causative factors would lead to early diagnosis and clearer prognosis of the diseases. This study aimed to find genetic biomarkers in blood to distinguish and identify CKDu from CKD as well as healthy populations from CKDu endemic and non-endemic areas of Sri Lanka. The expression patterns of a selected panel of 12 potential genetic biomarkers were analyzed in blood using RT-qPCR. Fold changes of gene expressions in early and late stages of CKD and CKDu patients, and an apparently healthy population of a CKDu endemic area, Girandurukotte (GH) were calculated relative to apparently healthy volunteers from a CKDu non-endemic area, Kandy (KH) of Sri Lanka, using the comparative CT method. Significant differences were observed between KH and early stage CKDu for both the insulin-like growth factor binding protein 1 (IGFBP1; p = 0.012) and kidney injury molecule-1 (KIM1; p = 0.003) genes, and KH and late stage CKD and CKDu for the glutathione-S-transferase mu 1 (GSTM1; p < 0.05) gene. IGFBP1 and KIM1 genes showed significant difference between the early and late stage CKDu (p < 0.01). The glutamate cysteine ligase catalytic subunit (GCLC) gene had significantly different expression between KH and all the other study groups (p < 0.01). The GH group was significantly different from the KH group for the oxidative stress related genes, G6PD, GCLC and GSTM1 (p < 0.01), and also the KIM1 gene (p = 0.003). IGFBP1, insulin-like growth factor binding protein 3 (IGFBP3), fibronectin 1 (FN1) and KIM1 showed significant correlations with serum creatinine, and IGFBP1, KIM1 and kallikrein 1 (KLK1) with eGFR (p < 0.05). A panel consisting of IGFBP1, KIM1, GCLC and GSTM1 genes could be used in combination for early screening of CKDu, whereas these genes in addition with FN1, IGFBP3 and

Current status of the East Sea Ecosystem in a changing world

NASA Astrophysics Data System (ADS)

Lee, Sang Heon; Kang, Chang-Keun; Lee, Chung IL; Kwak, Jung Hyun

2017-12-01

The East/Japan Sea (hereafter the East Sea) is changing quickly. Warming and structural changes in the East Sea have been reported by CREAMS, an acronym of ″Circulation Research of the East Asian Marginal Seas″, which began in 1993 as an international research program to understand the water mass structure and circulation in the East Sea (Kim and Kim, 1996; Kim, 1997; Kim et al., 2001, 2002). A subsequent research program of the EAST-I, an acronym of ″the East Asian Seas Time-series″, was launched by PICES (North Pacific Marine Science Organization) and financially supported by the Korean government, allowing us to deepen our knowledge about rapidly changing processes in the East Sea (Chang et al., 2010). Although there has been considerable progress in developing a mechanistic understanding of the East Sea ecosystem responses to disturbances, more comprehensive studies are needed to address the impacts of the frequency and intensity of disturbances on marine ecosystems. The most important question of the research has been: how do environmental changes affect structural and functional biodiversity? Recently launched research on ″Long-term change of structure and function in marine ecosystems of Korea″, which has been supported by the Korean government since 2011, has given an unprecedented insight into the ecosystem dynamics in the East Sea. It therefore seems an appropriate time to devote a special issue to the topic of ″Current status of the East Sea ecosystem in a changing world″.

Bedrock geologic map of the Montpelier and Barre West quadrangles, Washington and Orange Counties, Vermont

USGS Publications Warehouse

Walsh, Gregory J.; Kim, Jonathan; Gale, Marjorie H.; King, Sarah M.

2010-01-01

The bedrock geology of the Montpelier and Barre West quadrangles consists of Silurian and Devonian metasedimentary rocks of the Connecticut Valley-Gaspe synclinorium (CVGS) and metasedimentary, metavolcanic, and metaintrusive rocks of the Cambrian and Ordovician Moretown and Cram Hill Formations. Devonian granite dikes occur throughout the two quadrangles but are more abundant in the Silurian and Devonian rocks. The pre-Silurian rocks are separated from the rocks of the CVGS by the informally named 'Richardson Memorial Contact,' historically interpreted as either an unconformity or a fault. The results of this report represent mapping by G.J. Walsh, Jonathan Kim, and M.H. Gale from 2002 to 2005. S.M. King assisted Kim and Gale from 2002 to 2003. A.M. Satkoski (Indiana University) assisted Walsh, and L.R. Pascale (University of Vermont) and C.M. Orsi (Middlebury College) assisted Kim and Gale as summer interns in 2003. This study was designed to map the bedrock geology in the area. This map supersedes a preliminary map of the Montpelier quadrangle (Kim, Gale, and others, 2003). A companion study in the Barre West quadrangle (Walsh and Satkoski, 2005) determined the levels of naturally occurring radioactivity in the bedrock from surface measurements at outcrops during the course of 1:24,000-scale geologic mapping to identify which rock types were potential sources of radionuclides. Results of that study indicate that the carbonaceous phyllites in the CVGS have the highest levels of natural radioactivity.

Malicious MXit? South African adolescents' use of mobile-based communication applications.

PubMed

Swanepoel, Tarah L; Thomas, Kevin Gf

2012-10-01

Across the globe, and particularly in the high-income countries of the developed world, adolescents are resorting in increasing numbers to the virtual world for peer interaction and socialisation (Subrahmanyam, Smahel and Greenfield 2006). This new and popular way of relating through virtual mediums such as the Internet has sparked public concern, and has been a focus of academic debate. Ongoing debate in psychology literature discusses the notion of compulsive usage of online communication platforms (commonly termed Internet addiction), particularly among adolescents (Kim et al. 2006, Fu et al. 2010, Israelashvili, Kim and Bukobza 2012).

THE SINO-INDIAN ORIGIN OF CHEMEIA AND CHUMEIA AS SYNONYMS IN GREK, SIGNIFYING ALCHEMY

PubMed Central

Mahdihassan, S.

1984-01-01

In China the antecedent of alchemy is represented by the god of longevity emerging from the peach. The first synthetic drug, Kim-Yeh, red colloidal gold, signified gold-cum -herbal juice. Kim-Yeh=Kimiya (Arabic) =chemeia (Greek). Translated this gave Chrusozomion=Gold Ferment, specifying the drug. Rasayana was translated as Chumeia, herbal juice-incorporate and signified the art alchemy. Chemeia was Chinese and Chumeia, Indian. Originally each signified both, a drug of longevity and the art, alchemy. Finally the art of making red gold was misunderstood as the art of making gold itself PMID:22557463

Trouble Spots in Online Direct-to-Consumer Prescription Drug Promotion: Teaching Drug Marketers How to Inform Better or Spin Better? Comment on "Trouble Spots in Online Direct-to-Consumer Prescription Drug Promotion: A Content Analysis of FDA Warning Letters".

PubMed

Doran, Evan

2016-02-21

Hyosun Kim's report "Trouble Spots in Online Direct to Consumer Prescription Drug Promotion: A content Analysis of FDA Warning Letters" aims to teach marketers how to avoid breaching current Food and Drug Administration (FDA) guidelines in their online drug promotion. While Kim hopes to minimise the potential for online promotion to misinform consumers and the study is carefully conducted, teaching drug marketers how to avoid the common mistakes in online drug promotion is more likely to make marketers more adept at spinning information than appropriately balancing it. © 2016 by Kerman University of Medical Sciences.

Subsurface temperature estimation from climatology and satellite SST for the sea around Korean Peninsula 1Bong-Guk, Kim, 1Yang-Ki, Cho, 1Bong-Gwan, Kim, 1Young-Gi, Kim, 1Ji-Hoon, Jung 1School of Earth and Environmental Sciences, Seoul National University

NASA Astrophysics Data System (ADS)

Kim, Bong-Guk; Cho, Yang-Ki; Kim, Bong-Gwan; Kim, Young-Gi; Jung, Ji-Hoon

2015-04-01

Subsurface temperature plays an important role in determining heat contents in the upper ocean which are crucial in long-term and short-term weather systems. Furthermore, subsurface temperature affects significantly ocean ecology. In this study, a simple and practical algorithm has proposed. If we assume that subsurface temperature changes are proportional to surface heating or cooling, subsurface temperature at each depth (Sub_temp) can be estimated as follows PIC whereiis depth index, Clm_temp is temperature from climatology, dif0 is temperature difference between satellite and climatology in the surface, and ratio is ratio of temperature variability in each depth to surface temperature variability. Subsurface temperatures using this algorithm from climatology (WOA2013) and satellite SST (OSTIA) where calculated in the sea around Korean peninsula. Validation result with in-situ observation data show good agreement in the upper 50 m layer with RMSE (root mean square error) less than 2 K. The RMSE is smallest with less than 1 K in winter when surface mixed layer is thick, and largest with about 2~3 K in summer when surface mixed layer is shallow. The strong thermocline and large variability of the mixed layer depth might result in large RMSE in summer. Applying of mixed layer depth information for the algorithm may improve subsurface temperature estimation in summer. Spatial-temporal details on the improvement and its causes will be discussed.

Renoprotective mechanisms of soy protein intake in the obese Zucker rat

PubMed Central

Trujillo, Joyce; Cruz, Cristino; Tovar, Armando; Vaidya, Vishal; Zambrano, Elena; Bonventre, Joseph V.; Gamba, Gerardo; Torres, Nimbe; Bobadilla, Norma A.

2008-01-01

We previously showed that long-term consumption of a soy protein diet (SoyP) reduces renal damage in obese Zucker (ObeseZ) rats by restoring urinary NO2 and NO3 excretion (UNO2/NO3V), suggesting that nitric oxide (NO) deficiency may contribute to the renal progression observed in this model. In addition, there is compelling evidence that hyperleptinemia produced deleterious effects on the kidney through its interaction with the short leptin receptor (ObRa). This study was designed to evaluate the contribution of the NO/endothelial NO synthase (eNOS) system, renal oxidative stress, and ObRa expression to the renoprotection conferred by the consumption of a SoyP in ObeseZ rats. Ten lean and ten male ObeseZ rats were included. One-half of each group was fed with a 20% SoyP and the other half with a 20% casein protein diet (CasP) over the course of 160 days. eNOS protein levels and phosphorylation, renal lipoperoxidation (rLPO), and antioxidant enzyme activity were assessed. In addition, renal ObRa, TGF-β, and kidney injury molecule (Kim-1) mRNA levels, as well as urinary Kim-1 levels, were measured. Renal injury observed in ObeseZ rats fed with CasP was not associated with changes in eNOS expression or phosphorylation. However, this group did present with increased rLPO, reduced catalase activity, and upregulation of ObRa, TGF-β1, and Kim-1. In contrast, ObeseZ rats fed with a SoyP exhibited a reduction in NOS-Thr495 phosphorylation and rLPO, as well as an enhanced catalase activity. These findings were associated with a significant reduction of ObRa, TGF-β1, and Kim-1 mRNA levels and urinary Kim-1 protein. Our results show that renoprotection by SoyP in ObeseZ rats is in part mediated by increased NO availability secondary to a reduction in eNOS-T495 phosphorylation and oxidative stress, together with a significant reduction in ObRa and TGF-β expression. PMID:18815216

Dynamic and coordinated single-molecular interactions at TM4SF5-enriched microdomains guide invasive behaviors in 2- and 3-dimensional environments.

PubMed

Kim, Hye-Jin; Kwon, Sojung; Nam, Seo Hee; Jung, Jae Woo; Kang, Minkyung; Ryu, Jihye; Kim, Ji Eon; Cheong, Jin-Gyu; Cho, Chang Yun; Kim, Somi; Song, Dae-Geun; Kim, Yong-Nyun; Kim, Tai Young; Jung, Min-Kyo; Lee, Kyung-Min; Pack, Chan-Gi; Lee, Jung Weon

2017-04-01

Membrane proteins sense extracellular cues and transduce intracellular signaling to coordinate directionality and speed during cellular migration. They are often localized to specific regions, as with lipid rafts or tetraspanin-enriched microdomains; however, the dynamic interactions of tetraspanins with diverse receptors within tetraspanin-enriched microdomains on cellular surfaces remain largely unexplored. Here, we investigated effects of tetraspan(in) TM4SF5 (transmembrane 4 L6 family member 5)-enriched microdomains (T 5 ERMs) on the directionality of cell migration. Physical association of TM4SF5 with epidermal growth factor receptor (EGFR) and integrin α5 was visualized by live fluorescence cross-correlation spectroscopy and higher-resolution microscopy at the leading edge of migratory cells, presumably forming TM4SF5-enriched microdomains. Whereas TM4SF5 and EGFR colocalized at the migrating leading region more than at the rear, TM4SF5 and integrin α5 colocalized evenly throughout cells. Cholesterol depletion and disruption in TM4SF5 post-translational modifications, including N -glycosylation and palmitoylation, altered TM4SF5 interactions and cellular localization, which led to less cellular migration speed and directionality in 2- or 3-dimensional conditions. TM4SF5 controlled directional cell migration and invasion, and importantly, these TM4SF5 functions were dependent on cholesterol, TM4SF5 post-translational modifications, and EGFR and integrin α5 activity. Altogether, we showed that TM4SF5 dynamically interacted with EGFR and integrin α5 in migratory cells to control directionality and invasion.-Kim, H.-J., Kwon, S., Nam, S. H., Jung, J. W., Kang, M., Ryu, J., Kim, J. E., Cheong, J.-G., Cho, C. Y., Kim, S., Song, D.-G., Kim, Y.-N., Kim, T. Y., Jung, M.-K., Lee, K.-M., Pack, C.-G., Lee, J. W. Dynamic and coordinated single-molecular interactions at TM4SF5-enriched microdomains guide invasive behaviors in 2- and 3-dimensional environments. © FASEB.

Environmental exposure to arsenic and chromium in children is associated with kidney injury molecule-1

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cárdenas-González, M.

Environmental hazards from natural or anthropological sources are widespread, especially in the north-central region of Mexico. Children represent a susceptible population due to their unique routes of exposure and special vulnerabilities. In this study we evaluated the association of exposure to environmental kidney toxicants with kidney injury biomarkers in children living in San Luis Potosi (SLP), Mexico. A cross-sectional study was conducted with 83 children (5–12 years of age) residents of Villa de Reyes, SLP. Exposure to arsenic, cadmium, chromium, fluoride and lead was assessed in urine, blood and drinking water samples. Almost all tap and well water samples hadmore » levels of arsenic (81.5%) and fluoride (100%) above the permissible levels recommended by the World Health Organization. Mean urine arsenic (45.6 ppb) and chromium (61.7 ppb) were higher than the biological exposure index, a reference value in occupational settings. Using multivariate adjusted models, we found a dose-dependent association between kidney injury molecule-1 (KIM-1) across chromium exposure tertiles [(T1: reference, T2: 467 pg/mL; T3: 615 pg/mL) (p-trend=0.001)]. Chromium upper tertile was also associated with higher urinary miR-200c (500 copies/μl) and miR-423 (189 copies/μL). Arsenic upper tertile was also associated with higher urinary KIM-1 (372 pg/mL). Other kidney injury/functional biomarkers such as serum creatinine, glomerular filtration rate, albuminuria, neutrophil gelatinase-associated lipocalin and miR-21 did not show any association with arsenic, chromium or any of the other toxicants evaluated. We conclude that KIM-1 might serve as a sensitive biomarker to screen children for kidney damage induced by environmental toxic agents. - Highlights: • Children living in Mexico had exceedingly high arsenic and chromium exposure. • Arsenic and chromium exposure was significantly associated with urinary KIM-1. • KIM-1 might serve as a sensitive biomarker to evaluate

KSC-08pd1764

NASA Image and Video Library

2008-06-17

CAPE CANAVERAL, Fla. – 2008 Daytona 500 winner Ryan Newman leaves the Operations and Checkout Building at NASA's Kennedy Space Center, emulating the exit of shuttle crews before a launch. At left is Janet Petro, Kennedy's deputy center director. Behind them are Daytona International Speedway President Robin Braig (left) and Daytona 500 Experience General Manager Kim Isemann. Newman is visiting Kennedy in honor of NASA's 50th anniversary and the 50th running of NASCAR's Daytona 500 in February. NASA presented Newman two green racing flags that were flown last February aboard space shuttle Atlantis' STS-122 mission to the International Space Station. One flag was given to Newman, the second was presented to Daytona 500 Experience General Manager Kim Isemann. A third flag that was flown will be kept by NASA for public display. The connection between NASA and Daytona's International Speedway extends beyond their close proximity to one another. During recent years, technology developed for the space program has found many uses on Earth, including helping NASCAR drivers stay safe and increase performance. Photo credit: NASA/Kim Shiflett

Can concurrent memory load reduce distraction? A replication study and beyond.

PubMed

Gil-Gómez de Liaño, Beatriz; Stablum, Franca; Umiltà, Carlo

2016-01-01

The effects of concurrent working memory load in attentional processes have been 1 of the most puzzling issues in cognitive psychology. Studies have shown detrimental effects, no effects, and even beneficial effects of working memory load in different attentional tasks. In the present study we attempted to replicate Kim, Kim, and Chun's (2005, Experiment 3b) findings of beneficial effects of concurrent working memory load in a spatial Stroop-like task. In 3 experiments in which our sample was 3 times larger than that in the original Kim et al. study, we could not replicate their findings. The results are discussed in terms of what may have produced the conflicting results, trying to shed light on how working memory load affects attentional tasks. Also, we emphasize the importance of using adequately large samples in cognitive research. Although we acknowledge the relevance of meta-analyses to analyze conflicting results, in the present article we stress (perhaps more important) the power of an essential trademark in science for research development: replicability. (c) 2015 APA, all rights reserved).

Tubular damage and worsening renal function in chronic heart failure.

PubMed

Damman, Kevin; Masson, Serge; Hillege, Hans L; Voors, Adriaan A; van Veldhuisen, Dirk J; Rossignol, Patrick; Proietti, Gianni; Barbuzzi, Savino; Nicolosi, Gian Luigi; Tavazzi, Luigi; Maggioni, Aldo P; Latini, Roberto

2013-10-01

This study sought to investigate the relationship between tubular damage and worsening renal function (WRF) in chronic heart failure (HF) BACKGROUND: WRF is associated with poor outcome in chronic HF. It is unclear whether urinary tubular markers may identify patients at risk for WRF. In 2,011 patients with chronic HF, we evaluated the ability of urinary tubular markers (N-acetyl-beta-d-glucosaminidase (NAG), kidney injury molecule (KIM)-1, and neutrophil gelatinase-associated lipocalin (NGAL) to predict WRF. Finally, we assessed the prognostic importance of WRF. A total of 290 patients (14.4%) experienced WRF during follow-up, and WRF was a strong and independent predictor of all-cause mortality and HF hospitalizations (hazard ratio [HR]: 2.87; 95% CI: 2.40 to 3.43; p < 0.001). Patients with WRF had lower baseline glomerular filtration rate and higher KIM-1, NAG, and NGAL levels. In a multivariable-adjusted model, KIM-1 was the strongest independent predictor of WRF (HR: 1.23; 95% CI: 1.09 to 1.39 per log increase; p = 0.001). WRF was associated with strongly impaired outcome in patients with chronic HF. Increased level of urinary KIM-1 was the strongest independent predictor of WRF and could therefore be used to identify patients at risk for WRF and poor clinical outcome. (GISSI-HF-Effects of n-3 PUFA and Rosuvastatin on Mortality-Morbidity of Patients With Symptomatic CHF; NCT00336336). Copyright © 2013 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

The effect of a couples intervention to increase breast cancer screening among korean americans.

PubMed

Lee, Eunice; Menon, Usha; Nandy, Karabi; Szalacha, Laura; Kviz, Frederick; Cho, Young; Miller, Arlene; Park, Hanjong

2014-05-01

To assess the efficacy of Korean Immigrants and Mammography-Culture-Specific Health Intervention (KIM-CHI), an educational program for Korean American (KA) couples designed to improve mammography uptake among KA women. A two-group cluster randomized, longitudinal, controlled design. 50 KA religious organizations in the Chicago area. 428 married KA women 40 years of age or older who had not had a mammogram in the past year. The women and their husbands were recruited from 50 KA religious organizations. Couples were randomly assigned to intervention or attention control groups. Those in the KIM-CHI program (n = 211 couples) were compared to an attention control group (n = 217 couples) at baseline, as well as at 6 and 15 months postintervention on mammogram uptake. Sociodemographic variables and mammography uptake were measured. Level of acculturation was measured using the Suinn-Lew Asian Self-Identity Acculturation Scale. Researchers asked questions about healthcare resources and use, health insurance status, usual source of care, physical examinations in the past two years, family history of breast cancer, and history of mammography. The KIM-CHI group showed statistically significant increases in mammography uptake compared to the attention control group at 6 months and 15 months postintervention. The culturally targeted KIM-CHI program was effective in increasing mammogram uptake among nonadherent KA women. Nurses and healthcare providers should consider specific health beliefs as well as inclusion of husbands or significant others. They also should target education to be culturally relevant for KA women to effectively improve frequency of breast cancer screening.

Underestimation of substance abuse in psychiatric patients by conventional hospital screening.

PubMed

Reidy, Lisa J; Junquera, Patricia; Van Dijck, Karolien; Steele, Bernard W; Nemeroff, Charles B

2014-12-01

Psychiatric diagnosis mainly relies on behavioral signs and symptoms. Substance abuse can mimic the clinical presentation of primary psychiatric disorders and can also complicate the management of psychiatric patients. The reliability and accuracy of urine toxicology is a vital tool in the optimal treatment of these patients. Current demographics of substance abuse suggest that in addition to the most conventional drugs of abuse (e.g. cocaine, cannabis) that are of concern to treating physicians, prescription medications and new designer drugs also should be when evaluating patients who present with symptoms of psychosis/drug addiction or altered mental status. Urine samples from 220 psychiatric inpatients admitted to either an acute drug and alcohol unit or acute psychiatric unit were analyzed for drugs by the standard hospital assay (KIMS) and by a more sensitive ELISA and GC-MS basic drug screening protocol. The standard hospital toxicology (KIMS) was inferior to the ELISA and GC-MS methods in terms of both assay sensitivity and in detecting a broader number of drugs. The KIMS tests failed to identify opiates and amphetamine/methamphetamine in 50% of the patients. The KIMS screen did not identify zolpidem, buprenorphine and a number of synthetic drugs of abuse including cathinone and tryptamines. In order to reliably identify substance abuse in patients with altered mental status in inpatient settings, analytical methodologies with adequate assay sensitivity and range to detect the vast majority of commonly abused illicit drugs and prescription medications are required for optimal clinical assessment and treatment. Copyright © 2014 Elsevier Ltd. All rights reserved.

Increased plasma Kidney Injury Molecule-1 suggests early progressive renal decline in non-proteinuric patients with Type 1 diabetes

PubMed Central

Nowak, Natalia; Skupien, Jan; Niewczas, Monika A.; Yamanouchi, Masayuki; Major, Melissa; Croall, Stephanie; Smiles, Adam; Warram, James H.; Bonventre, Joseph V.; Krolewski, Andrzej S.

2015-01-01

Progressively decreasing glomerular filtration rate (GFR), or renal decline, is seen in patients with type 1 diabetes (T1D) and normoalbuminuria or microalbuminuria. Here we examined the associations of kidney injury molecule-1 (KIM-1) in plasma and urine with the risk of renal decline and determine whether those associations are independent of markers of glomerular damage. The study group comprised patients with T1D from the 2nd Joslin Kidney Study of which 259 had normoalbuminuria and 203 had microalbuminuria. Serial measurements over 4 to 10 years of follow-up (median 8 years) of serum creatinine and cystatin C were used jointly to estimate eGFRcr-cys slopes and time of onset of CKD stage 3 or higher. Baseline urinary excretion of IgG2 and albumin were used as markers of glomerular damage, and urinary excretion of KIM-1 and its plasma concentration were used as markers of proximal tubular damage. All patients had normal renal function at baseline. During follow-up, renal decline (eGFRcr-cys loss 3.3% or more per year) developed in 96 patients and 62 progressed to CKD stage 3. For both outcomes, the risk rose with increasing baseline levels of plasma KIM-1. In multivariable models, elevated baseline plasma KIM-1 was strongly associated with risk of early progressive renal decline, regardless of baseline clinical characteristics, serum TNFR1 or markers of glomerular damage. Thus, damage to proximal tubules may play an independent role in the development of early progressive renal decline in non-proteinuric patients with T1D. PMID:26509588

Fluorinated Materials for Air-stable and Moisture-resistant Flexible Optoelectronics

DTIC Science & Technology

2014-01-02

Kim Jong , H.; Shin, S.; Yang, H.; An, B.-K.; Yang, L.; Park Soo, Y. Adv Mater 2012, 24, 911-915; (c) Geng, Y.; Li, H.-B.; Wu, S.-X.; Su, Z.-M. J...Park, J.-U.; Shir, D. J.-L.; Nam , Y.-S.; Jeon, S.; Rogers, J. A. Chem. Rev. 2007, 107, 1117-1160; (g) Murphy, A. R.; Frechet, J. M. J. Chem. Rev. 2007...2649-2655; (w) Song, H.-J.; Kim , D.-H.; Lee, E.-J.; Heo, S.-W.; Lee, J.-Y.; Moon, D.-K. Macromolecules (Washington, DC, U. S.) 2012, 45, 7815- 7822; (x

Development of Efficient Charge-Selective Materials for Bulk Heterojunction Polymer Solar Cells

DTIC Science & Technology

2015-01-15

Cho, D. S. Ginger and A. K. Y. Jen, Advanced Materials, 2014, 26, 6262-6267. 17. N. Cho, C.-Z. Li, H.-L. Yip and A. K. Y. Jen, Energy...Solar Cells”, Adv. Funct. Mater. 2015, ASAP. 4. J. H. Kim, P. W. Liang, S. T. Williams, N. C. Cho, C. C. Chueh, M. S. Glaz, D. S. Ginger , A. K.-Y...Kim, P. W. Liang, S. T. Williams, N. C. Cho, C. C. Chueh, M. S. Glaz, D. S. Ginger , A. K.-Y. Jen, 2015, ASAP. 7. P. W. Liang, C. C. Chueh, X. K

Effects of Maternal Exposure to Cadmium Oxide Nanoparticles During Pregnancy on Maternal and Offspring Kidney Injury Markers Using a Murine Model.

PubMed

Blum, Jason L; Edwards, Joshua R; Prozialeck, Walter C; Xiong, Judy Q; Zelikoff, Judith T

2015-01-01

Nanoparticles (NP) are pervasive in many areas of modern life, with little known about their potential toxicities. One commercially important NP is cadmium oxide (CdO), which is used to synthesize other Cd-containing NP, such as quantum dots. Cadmium (Cd) is a well-known nephrotoxicant, but the nephrotoxic potential of CdO NP remains unknown, particularly when exposure occurs during pregnancy. Therefore, pregnant CD-1 mice were used to examine the effects of inhaled CdO NP (230 μg CdO NP/m(3)) on maternal and neonatal renal function by examining urinary creatinine and urinary biomarkers of kidney injury, including kidney injury molecule-1 (Kim-1) and neutrophil gelatinase-associated lipocalin (NGAL). Inhalation of CdO NP by dams produced a fivefold increase in urinary Kim-1 with no marked effect on urinary creatinine levels. Kim-1 mRNA expression peaked by gestational day (GD) 10.5, and NGAL expression increased from GD 10.5 to 17.5. In addition, histological analyses revealed proximal tubular pathology at GD 10.5. Neonatal Kim-1 mRNA expression rose between postnatal days (PND) 7 and 14, with mammary glands/milk being the apparent source of Cd for offspring. These studies demonstrate that, similar to what is seen with other Cd forms, Cd associated with inhaled CdO NP results in renal injury to both directly exposed dam and offspring. As commercial uses for nanotechnology continue to expand throughout the world, risks for unintentional exposure in the workplace increase. Given the large number of women in the industrial workforce, care needs to be taken to protect these already vulnerable populations.

Field-dependent critical state of high-Tc superconducting strip simultaneously exposed to transport current and perpendicular magnetic field

DOE Office of Scientific and Technical Information (OSTI.GOV)

Xue, Cun; He, An; Yong, Huadong

We present an exact analytical approach for arbitrary field-dependent critical state of high-T{sub c} superconducting strip with transport current. The sheet current and flux-density profiles are derived by solving the integral equations, which agree with experiments quite well. For small transport current, the approximate explicit expressions of sheet current, flux-density and penetration depth for the Kim model are derived based on the mean value theorem for integration. We also extend the results to the field-dependent critical state of superconducting strip in the simultaneous presence of applied field and transport current. The sheet current distributions calculated by the Kim model agreemore » with experiments better than that by the Bean model. Moreover, the lines in the I{sub a}-B{sub a} plane for the Kim model are not monotonic, which is quite different from that the Bean model. The results reveal that the maximum transport current in thin superconducting strip will decrease with increasing applied field which vanishes for the Bean model. The results of this paper are useful to calculate ac susceptibility and ac loss.« less

Evaluation of a new five-injection, two-site,intradermal schedule for purified chick embryo cell rabies vaccine: A randomized, open-label, active-controlled trial in healthy adult volunteers in India.

PubMed

Sudarshan, M K; Madhusudana, S N; Mahendra, B J; Ashwath Narayana, D H; Ananda Giri, M S; Popova, O; Vakil, H B

2005-07-01

Human rabies is an ongoing significant public health problem inmany developing countries, with India reporting the highest incidence of rabies-related deaths (∼20,000 per year). Many people living in India cannot afford the standard IM postexposure prophylaxis (PEP) with cell-culture vaccines, which are administered using a 5-dose regimen developed in Essen, Germany. A potentially less expensive intradermal (ID) regimen, based on the Essen regimen, has been developed at the Kempegowda Institute of Medical Sciences (KIMS), Bangalore, India. The objective of this study was to compare the immunogenicity and local and systemic tolerability of the KIMS-1D regimen with those of the standard Essen IM regimen in healthy adult volunteers in India. This randomized, open-label, active-controlled trial was conductedat the Antirabies Clinic, Medical College, KIMS. Healthy adult volunteers were randomly assigned to receive purified chick embryo cell vaccine (PCECV) using the KIMS-1D regimen (0.1 mL injected ID at 2 body sites on days 0, 3, 7, 14, and 28 ["2-2-2-2-2"]) or the Essen IM regimen (1 mL injected IM at 1 body site on the same days Subjects were followed up for 365 days by the treating physician and encouraged to voluntarily report any adverse events (AEs). Serum rabies virus-neutralizing antibody (RVNA) concentrations were measured before the first injection on day 0 (baseline) and on days 14, 28, 90, 180, and 365, using the rapid fluorescent focus inhibition test. Ninety-one subjects were enrolled and included in the tolerabilityand immunogenicity analyses. The ID group comprised 45 subjects (26 men, 19 women; mean [SD] age, 20.84 [1.48] years); the IM group, 46 subjects (28 men, 18 women; mean [SD] age, 21.02 [1.16] years). The most common local AEs were pain at the injection site (2/225 [0.9%] in the ID group and 10/230 [4.3%] in the IM group; P < 0.006) and itching at the injection site (5/225 [2.2%] in the ID group and none in the IM group; P = 0.026). All of

Report on the Implementation of Homogeneous Nucleation Scheme in MARMOT-based Phase Field Simulation

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Yulan; Hu, Shenyang Y.; Sun, Xin

2013-09-30

phase field modeling in order to correctly capture the kinetics of precipitation. In most alloys the matrix phase and precipitate phase have different concentrations as well as different crystal structures. For example, Cu precipitates in FeCu alloys have fcc crystal structure while the matrix Fe-Cu solid solution has bcc structure at low temperature. The WBM model and KimS model, where both concentrations and order parameters are chosen to describe the microstructures, are commonly used to model precipitations in such alloys. The WBM and KimS models have not been implemented into Marmot yet. In the second part of this report, we focused on implementing the WBM and KimS models into Marmot. The Fe-Cu alloys, which are important structure materials in nuclear reactors, was taken as the model alloys to test the models.« less

Novel urinary biomarkers and the early detection of acute kidney injury after open cardiac surgeries.

PubMed

Elmedany, Said M; Naga, Salah S; Elsharkawy, Rania; Mahrous, Rabab S; Elnaggar, Ahmed I

2017-08-01

Acute kidney injury (AKI) is a common complication after cardiac surgery, recently, several biomarkers have been used to facilitate early detection of AKI, including Neutrophil-gelatinase-associated-lipocalin (NGAL) and Kidney-injury-molecule-1 (KIM-1).This study was carried out to study the efficacy of urinary KIM-1 and NGAL separately and in combination in relation to early detection and assessment of severity of AKI after cardiac surgeries. This prospective study was carried out on 45 adult patients, of both sexes, Cleveland score(CCS) (0-5) and scheduled for elective coronary artery bypass graft (CABG) surgery in Alexandria Main University Hospital, after approval of the ethical committee and having an informed written consent from every patient. Patients were screened for renal function tests before surgery and every day for 3 day after surgery. Freshly urine samples were taken from all patients and centrifuged for microscopic examination of the sediment: preoperative, 2, 12, 24, and 48 hr after cardiopulmonary bypass (CPB) and for measurement of NGAL and KIM-1; after induction, 2, 6, 12, and 24 hr after CPB. The primary end point was the incidence of AKI defined by the AKIN criteria of serum creatinine. 11 patients developed AKI. Patients with AKI had a higher AKIN stages and CCS. CPB time and cross clamp time were significantly higher in the AKI group with a mean of (90.5±16.2) and (60.9±8.1) minutes respectively. Serum creatinine started to be significantly higher in AKI group from the second postoperative day with a mean value of 1.56±0.28 mg/dl compared to a mean value of 0.85±0.14 mg/dl in non-AKI group. Urine sediment score(USS) 1 and 2 were higher in the AKI group than in the non-AKI group 2 hrs after CPB and till the end of the 2nd day with area under the curve (AUC) average of (0.865). Urinary NGAL significantly rise in AKI patients 2 and 6 hr after CPB with corresponding AUC of (0.710 and 0.700) but uKIM-1 was higher in the AKI group 12 and 24

Validation of newly developed and redesigned key indicator methods for assessment of different working conditions with physical workloads based on mixed-methods design: a study protocol

PubMed Central

Liebers, Falk; Brandstädt, Felix; Schust, Marianne; Serafin, Patrick; Schäfer, Andreas; Gebhardt, Hansjürgen; Hartmann, Bernd; Steinberg, Ulf

2017-01-01

Introduction The impact of work-related musculoskeletal disorders is considerable. The assessment of work tasks with physical workloads is crucial to estimate the work-related health risks of exposed employees. Three key indicator methods are available for risk assessment regarding manual lifting, holding and carrying of loads; manual pulling and pushing of loads; and manual handling operations. Three further KIMs for risk assessment regarding whole-body forces, awkward body postures and body movement have been developed de novo. In addition, the development of a newly drafted combined method for mixed exposures is planned. All methods will be validated regarding face validity, reliability, convergent validity, criterion validity and further aspects of utility under practical conditions. Methods and analysis As part of the joint project MEGAPHYS (multilevel risk assessment of physical workloads), a mixed-methods study is being designed for the validation of KIMs and conducted in companies of different sizes and branches in Germany. Workplaces are documented and analysed by observations, applying KIMs, interviews and assessment of environmental conditions. Furthermore, a survey among the employees at the respective workplaces takes place with standardised questionnaires, interviews and physical examinations. It is intended to include 1200 employees at 120 different workplaces. For analysis of the quality criteria, recommendations of the COSMIN checklist (COnsensus-based Standards for the selection of health Measurement INstruments) will be taken into account. Ethics and dissemination The study was planned and conducted in accordance with the German Medical Professional Code and the Declaration of Helsinki as well as the German Federal Data Protection Act. The design of the study was approved by ethics committees. We intend to publish the validated KIMs in 2018. Results will be published in peer-reviewed journals, presented at international meetings and disseminated

Braun lipoprotein (Lpp) contributes to virulence of yersiniae: potential role of Lpp in inducing bubonic and pneumonic plague.

PubMed

Sha, Jian; Agar, Stacy L; Baze, Wallace B; Olano, Juan P; Fadl, Amin A; Erova, Tatiana E; Wang, Shaofei; Foltz, Sheri M; Suarez, Giovanni; Motin, Vladimir L; Chauhan, Sadhana; Klimpel, Gary R; Peterson, Johnny W; Chopra, Ashok K

2008-04-01

Yersinia pestis evolved from Y. pseudotuberculosis to become the causative agent of bubonic and pneumonic plague. We identified a homolog of the Salmonella enterica serovar Typhimurium lipoprotein (lpp) gene in Yersinia species and prepared lpp gene deletion mutants of Y. pseudotuberculosis YPIII, Y. pestis KIM/D27 (pigmentation locus minus), and Y. pestis CO92 with reduced virulence. Mice injected via the intraperitoneal route with 5 x 10(7) CFU of the Deltalpp KIM/D27 mutant survived a month, even though this would have constituted a lethal dose for the parental KIM/D27 strain. Subsequently, these Deltalpp KIM/D27-injected mice were solidly protected against an intranasally administered, highly virulent Y. pestis CO92 strain when it was given as five 50% lethal doses (LD(50)). In a parallel study with the pneumonic plague mouse model, after 72 h postinfection, the lungs of animals infected with wild-type (WT) Y. pestis CO92 and given a subinhibitory dose of levofloxacin had acute inflammation, edema, and masses of bacteria, while the lung tissue appeared essentially normal in mice inoculated with the Deltalpp mutant of CO92 and given the same dose of levofloxacin. Importantly, while WT Y. pestis CO92 could be detected in the bloodstreams and spleens of infected mice at 72 h postinfection, the Deltalpp mutant of CO92 could not be detected in those organs. Furthermore, the levels of cytokines/chemokines detected in the sera were significantly lower in animals infected with the Deltalpp mutant than in those infected with WT CO92. Additionally, the Deltalpp mutant was more rapidly killed by macrophages than was the WT CO92 strain. These data provided evidence that the Deltalpp mutants of yersiniae were significantly attenuated and could be useful tools in the development of new vaccines.

Increased GABA Levels in Medial Prefrontal Cortex of Young Adults with Narcolepsy

PubMed Central

Kim, Seog Ju; Lyoo, In Kyoon; Lee, Yujin S.; Sung, Young Hoon; Kim, Hengjun J.; Kim, Jihyun H.; Kim, Kye Hyun; Jeong, Do-Un

2008-01-01

Study Objectives: To explore absolute concentrations of brain metabolites including gamma amino-butyric acid (GABA) in the medial prefrontal cortex and basal ganglia of young adults with narcolepsy. Design: Proton magnetic resonance (MR) spectroscopy centered on the medial prefrontal cortex and the basal ganglia was acquired. The absolute concentrations of brain metabolites including GABA and glutamate were assessed and compared between narcoleptic patients and healthy comparison subjects. Setting: Sleep and Chronobiology Center at Seoul National University Hospital; A high strength 3.0 Tesla MR scanner in the Department of Radiology at Seoul National University Hospital. Patients or Participants: Seventeen young adults with a sole diagnosis of HLA DQB1 0602 positive narcolepsy with cataplexy (25.1 ± 4.6 years old) and 17 healthy comparison subjects (26.8 ± 4.8 years old). Interventions: N/A. Measurements and Results: Relative to comparison subjects, narcoleptic patients had higher GABA concentration in the medial prefrontal cortex (t = 4.10, P <0.001). Narcoleptic patients with nocturnal sleep disturbance had higher GABA concentration in the medial prefrontal cortex than those without nocturnal sleep disturbance (t = 2.45, P= 0.03), but had lower GABA concentration than comparison subjects (t = 2.30, P = 0.03). Conclusions: The current study reports that young adults with narcolepsy had a higher GABA concentration in the medial prefrontal cortex, which was more prominent in patients without nocturnal sleep disturbance. Our findings suggest that the medial prefrontal GABA level may be increased in narcolepsy, and the increased medial prefrontal GABA might be a compensatory mechanism to reduce nocturnal sleep disturbances in narcolepsy. Citation: Kim SJ; Lyoo IK; Lee YS; Sung YH; Kim HJ; Kim JH; Kim KH; Jeong DU. Increased GABA levels in medial prefrontal cortex of young adults with narcolepsy. SLEEP 2008;31(3):342-347. PMID:18363310

Plasma Biomarkers and Kidney Function Decline in Early and Established Diabetic Kidney Disease.

PubMed

Coca, Steven G; Nadkarni, Girish N; Huang, Yuan; Moledina, Dennis G; Rao, Veena; Zhang, Jane; Ferket, Bart; Crowley, Susan T; Fried, Linda F; Parikh, Chirag R

2017-09-01

Biomarkers of diverse pathophysiologic mechanisms may improve risk stratification for incident or progressive diabetic kidney disease (DKD) in persons with type 2 diabetes. To evaluate such biomarkers, we performed a nested case-control study ( n =190 cases of incident DKD and 190 matched controls) and a prospective cohort study ( n =1156) using banked baseline plasma samples from participants of randomized, controlled trials of early (ACCORD) and advanced (VA NEPHRON-D) DKD. We assessed the association and discrimination obtained with baseline levels of plasma TNF receptor-1 (TNFR-1), TNFR-2, and kidney injury molecule-1 (KIM-1) for the outcomes of incident DKD (ACCORD) and progressive DKD (VA-NEPHRON-D). At baseline, median concentrations of TNFR-1, TNFR-2, and KIM-1 were roughly two-fold higher in the advanced DKD population (NEPHRON-D) than in the early DKD population (ACCORD). In both cohorts, patients who reached the renal outcome had higher baseline levels than those who did not reach the outcome. Associations between doubling in TNFR-1, TNFR-2, and KIM-1 levels and risk of the renal outcomes were significant for both cohorts. Inclusion of these biomarkers in clinical models increased the area under the curve (SEM) for predicting the renal outcome from 0.68 (0.02) to 0.75 (0.02) in NEPHRON-D. Systematic review of the literature illustrated high consistency in the association between these biomarkers of inflammation and renal outcomes in DKD. In conclusion, TNFR-1, TNFR-2, and KIM-1 independently associated with higher risk of eGFR decline in persons with early or advanced DKD. Moreover, addition of these biomarkers to clinical prognostic models significantly improved discrimination for the renal outcome. Copyright © 2017 by the American Society of Nephrology.

Comment on ‘Monogamy of multi-qubit entanglement using Rényi entropy’

NASA Astrophysics Data System (ADS)

Yu, Long-Bao; Zhang, Li-Hua; Zhao, Jun-Long; Tang, Yong-Sheng

2018-02-01

In an article in 2010, Kim et al introduced the definition of Rényi-α entanglement for bipartite quantum states and established an analytic formula of Rényi-α entanglement for arbitrary two-qubit states with α≥slant 1 . They also derived a monogamy of entanglement in multi-qubit systems in terms of Rényi-α entanglement for α≥slant 2 Kim et al (2010 J. Phys. A: Math. Theor. 43 445305). We find the proofs of theorems 2 and 3 contain some errors and we also present an improved derivation to overcome this flaw. The alternative derivation shows that the main conclusions remain valid despite the invalidity of the proofs.

Colon Reference Set Application: Nam Kim - DiaDexus (2008) — EDRN Public Portal

Cancer.gov

The EDRN Colorectal reference samples will be useful in confirming the potential application of novel serum markers for colorectal cancer that can detect presence of cancer in high-risk asymptomatic patients.

Production of Recombinant Injectosome and Outer Membrane Proteins from Yersinia Pestis KIM5

DTIC Science & Technology

2009-06-01

Overview ........................................................................ 45 20. Test Ammonium Sulfate Precipitation Overview...52 24. LcrV and YscF Test Expressions .................................................................. 53...coli modify the proteins’ primary structure post - translationally? 1.5 Significance of Results The study of VHH as immunotherapeutics for combating

The Clustering of Galaxies and Dark Matter at Intermediate Redshifts

NASA Technical Reports Server (NTRS)

Jain, Bhuvnesh; Szalay, Alexander

2003-01-01

Theoretical work in the study of weak lensing was begun while the Scientific PI (Jain) was at the Johns Hopkins University. A new postdoctoral fellow, Rita Kim, was hired to work for 0.5 years on the proposed research. She was unable to join JHU until March 2001 owing to delays in her PhD work. Meanwhile PI Jain moved to the University of Pennsylvania in January 2001. Owing to the above circumstances, the work for the proposed research was delayed and was expected to be carried out in the remainder of 2001. New measures of lensing based on the magnification effect were to be investigated by Drs. Jain and Kim. The simulations needed to test the analytical computations were already in place; hence the work was expected to proceed fairly rapidly. Owing to the close proximity of JHU and UPenn, the collaborative work was expected to proceed smoothly. It was requested therefore that the funds for the first grant year (2000-2001) be transferred to the second year. Part of the funding was spent at JHU on the salary for the Postdoctoral Fellow, Rita Kim, and the remainder at the University of Pennsylvania. The work from this grant is incomplete and will be continued under another grant.

YopP-expressing variant of Y. pestis activates a potent innate immune response affording cross-protection against yersiniosis and tularemia [corrected].

PubMed

Zauberman, Ayelet; Flashner, Yehuda; Levy, Yinon; Vagima, Yaron; Tidhar, Avital; Cohen, Ofer; Bar-Haim, Erez; Gur, David; Aftalion, Moshe; Halperin, Gideon; Shafferman, Avigdor; Mamroud, Emanuelle

2013-01-01

Plague, initiated by Yersinia pestis infection, is a rapidly progressing disease with a high mortality rate if not quickly treated. The existence of antibiotic-resistant Y. pestis strains emphasizes the need for the development of novel countermeasures against plague. We previously reported the generation of a recombinant Y. pestis strain (Kim53ΔJ+P) that over-expresses Y. enterocolitica YopP. When this strain was administered subcutaneously to mice, it elicited a fast and effective protective immune response in models of bubonic, pneumonic and septicemic plague. In the present study, we further characterized the immune response induced by the Kim53ΔJ+P recombinant strain. Using a panel of mouse strains defective in specific immune functions, we observed the induction of a prompt protective innate immune response that was interferon-γ dependent. Moreover, inoculation of mice with Y. pestis Kim53ΔJ+P elicited a rapid protective response against secondary infection by other bacterial pathogens, including the enteropathogen Y. enterocolitica and the respiratory pathogen Francisella tularensis. Thus, the development of new therapies to enhance the innate immune response may provide an initial critical delay in disease progression following the exposure to highly virulent bacterial pathogens, extending the time window for successful treatment.

Enhanced Two-Factor Authentication and Key Agreement Using Dynamic Identities in Wireless Sensor Networks.

PubMed

Chang, I-Pin; Lee, Tian-Fu; Lin, Tsung-Hung; Liu, Chuan-Ming

2015-11-30

Key agreements that use only password authentication are convenient in communication networks, but these key agreement schemes often fail to resist possible attacks, and therefore provide poor security compared with some other authentication schemes. To increase security, many authentication and key agreement schemes use smartcard authentication in addition to passwords. Thus, two-factor authentication and key agreement schemes using smartcards and passwords are widely adopted in many applications. Vaidya et al. recently presented a two-factor authentication and key agreement scheme for wireless sensor networks (WSNs). Kim et al. observed that the Vaidya et al. scheme fails to resist gateway node bypassing and user impersonation attacks, and then proposed an improved scheme for WSNs. This study analyzes the weaknesses of the two-factor authentication and key agreement scheme of Kim et al., which include vulnerability to impersonation attacks, lost smartcard attacks and man-in-the-middle attacks, violation of session key security, and failure to protect user privacy. An efficient and secure authentication and key agreement scheme for WSNs based on the scheme of Kim et al. is then proposed. The proposed scheme not only solves the weaknesses of previous approaches, but also increases security requirements while maintaining low computational cost.

Enhanced Two-Factor Authentication and Key Agreement Using Dynamic Identities in Wireless Sensor Networks

PubMed Central

Chang, I-Pin; Lee, Tian-Fu; Lin, Tsung-Hung; Liu, Chuan-Ming

2015-01-01

Key agreements that use only password authentication are convenient in communication networks, but these key agreement schemes often fail to resist possible attacks, and therefore provide poor security compared with some other authentication schemes. To increase security, many authentication and key agreement schemes use smartcard authentication in addition to passwords. Thus, two-factor authentication and key agreement schemes using smartcards and passwords are widely adopted in many applications. Vaidya et al. recently presented a two-factor authentication and key agreement scheme for wireless sensor networks (WSNs). Kim et al. observed that the Vaidya et al. scheme fails to resist gateway node bypassing and user impersonation attacks, and then proposed an improved scheme for WSNs. This study analyzes the weaknesses of the two-factor authentication and key agreement scheme of Kim et al., which include vulnerability to impersonation attacks, lost smartcard attacks and man-in-the-middle attacks, violation of session key security, and failure to protect user privacy. An efficient and secure authentication and key agreement scheme for WSNs based on the scheme of Kim et al. is then proposed. The proposed scheme not only solves the weaknesses of previous approaches, but also increases security requirements while maintaining low computational cost. PMID:26633396

Argumentation in elementary science education: addressing methodological issues and conceptual understanding

NASA Astrophysics Data System (ADS)

Kaya, Ebru

2017-11-01

In this review essay I respond to issues raised in Mijung Kim and Wolff-Michael Roth's paper titled "Dialogical argumentation in elementary science classrooms", which presents a study dealing with dialogical argumentation in early elementary school classrooms. Since there is very limited research on lower primary school students' argumentation in school science, their paper makes a contribution to research on children's argumentation skills. In this response, I focus on two main issues to extend the discussion in Kim and Roth's paper: (a) methodological issues including conducting a quantitative study on children's argumentation levels and focusing on children's written argumentation in addition to their dialogical argumentation, and (b) investigating children's conceptual understanding along with their argumentation levels. Kim and Roth emphasize the difficulty in determining the level of children's argumentation through the Toulmin's Argument Pattern and lack of high level arguments by children due to their difficulties in writing texts. Regarding these methodological issues, I suggest designing quantitative research on coding children's argument levels because such research could potentially provide important findings on children's argumentation. Furthermore, I discuss alternative written products including posters, figures, or pictures generated by children in order to trace children's arguments, and finally articulating argumentation and conceptual understanding of children.

Sources of spurious force oscillations from an immersed boundary method for moving-body problems

NASA Astrophysics Data System (ADS)

Lee, Jongho; Kim, Jungwoo; Choi, Haecheon; Yang, Kyung-Soo

2011-04-01

When a discrete-forcing immersed boundary method is applied to moving-body problems, it produces spurious force oscillations on a solid body. In the present study, we identify two sources of these force oscillations. One source is from the spatial discontinuity in the pressure across the immersed boundary when a grid point located inside a solid body becomes that of fluid with a body motion. The addition of mass source/sink together with momentum forcing proposed by Kim et al. [J. Kim, D. Kim, H. Choi, An immersed-boundary finite volume method for simulations of flow in complex geometries, Journal of Computational Physics 171 (2001) 132-150] reduces the spurious force oscillations by alleviating this pressure discontinuity. The other source is from the temporal discontinuity in the velocity at the grid points where fluid becomes solid with a body motion. The magnitude of velocity discontinuity decreases with decreasing the grid spacing near the immersed boundary. Four moving-body problems are simulated by varying the grid spacing at a fixed computational time step and at a constant CFL number, respectively. It is found that the spurious force oscillations decrease with decreasing the grid spacing and increasing the computational time step size, but they depend more on the grid spacing than on the computational time step size.

75 FR 11133 - Fisheries of the South Atlantic; South Atlantic Fishery Management Council; Public Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-10

... of the South Atlantic Fishery Management Council, 4055 Faber Place Drive, Suite 201, North Charleston...: Kim Iverson, Public Information Officer, South Atlantic Fishery Management Council, 4055 Faber Place...

78 FR 59916 - Fisheries of the South Atlantic; South Atlantic Fishery Management Council; Public Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-09-30

... Atlantic Fishery Management Council, 4055 Faber Place Drive, Suite 201, N. Charleston, SC 29405. FOR FURTHER INFORMATION CONTACT: Kim Iverson, Public Information Officer, 4055 Faber Place Drive, Suite 201...

76 FR 3091 - Fisheries of the South Atlantic and Gulf of Mexico; South Atlantic Fishery Management Council...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-01-19

... Atlantic Fishery Management Council, 4055 Faber Place Drive 201, North Charleston, SC 29405. FOR FURTHER INFORMATION CONTACT: Kim Iverson, Public Information Officer, 4055 Faber Place Drive, Suite 201, North...

75 FR 12507 - Fisheries of the South Atlantic and Gulf of Mexico; South Atlantic Fishery Management Council...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-16

... Faber Place Drive, Suite 201, North Charleston, SC 29405. FOR FURTHER INFORMATION CONTACT: Kim Iverson, Public Information Officer, 4055 Faber Place Drive, Suite 201, North Charleston, SC 29405; telephone...

77 FR 25144 - Fisheries of the South Atlantic; South Atlantic Fishery Management Council; Public Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2012-04-27

... Faber Place Drive, Suite 201, N. Charleston, SC, 29405. FOR FURTHER INFORMATION CONTACT: Kim Iverson, Public Information Officer, South Atlantic Fishery Management Council, 4055 Faber Place Drive, Suite 201...

77 FR 63872 - Senior Executive Service; Appointment of Members to the Performance Review Board

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2012-10-17

... Resources--Kim L.H. Green. Rotating Membership ASP Kathleen E. Franks, Director, Office of Regulatory and... OLMS Stephen J. Willertz, Director, Office of Enforcement and International Union Audits--appointment...

Evaluation of a new five-injection, two-site,intradermal schedule for purified chick embryo cell rabies vaccine: A randomized, open-label, active-controlled trial in healthy adult volunteers in India

PubMed Central

Sudarshan, M.K.; Madhusudana, S.N.; Mahendra, B.J.; Ashwath Narayana, D.H.; Ananda Giri, M.S.; Popova, O.; Vakil, H.B.

2005-01-01

Background: Human rabies is an ongoing significant public health problem inmany developing countries, with India reporting the highest incidence of rabies-related deaths (∼20,000 per year). Many people living in India cannot afford the standard IM postexposure prophylaxis (PEP) with cell-culture vaccines, which are administered using a 5-dose regimen developed in Essen, Germany. A potentially less expensive intradermal (ID) regimen, based on the Essen regimen, has been developed at the Kempegowda Institute of Medical Sciences (KIMS), Bangalore, India. Objective: The objective of this study was to compare the immunogenicity and local and systemic tolerability of the KIMS-1D regimen with those of the standard Essen IM regimen in healthy adult volunteers in India. Methods: This randomized, open-label, active-controlled trial was conductedat the Antirabies Clinic, Medical College, KIMS. Healthy adult volunteers were randomly assigned to receive purified chick embryo cell vaccine (PCECV) using the KIMS-1D regimen (0.1 mL injected ID at 2 body sites on days 0, 3, 7, 14, and 28 [“2-2-2-2-2”]) or the Essen IM regimen (1 mL injected IM at 1 body site on the same days Subjects were followed up for 365 days by the treating physician and encouraged to voluntarily report any adverse events (AEs). Serum rabies virus-neutralizing antibody (RVNA) concentrations were measured before the first injection on day 0 (baseline) and on days 14, 28, 90, 180, and 365, using the rapid fluorescent focus inhibition test. Results: Ninety-one subjects were enrolled and included in the tolerabilityand immunogenicity analyses. The ID group comprised 45 subjects (26 men, 19 women; mean [SD] age, 20.84 [1.48] years); the IM group, 46 subjects (28 men, 18 women; mean [SD] age, 21.02 [1.16] years). The most common local AEs were pain at the injection site (2/225 [0.9%] in the ID group and 10/230 [4.3%] in the IM group; P < 0.006) and itching at the injection site (5/225 [2.2%] in the ID group

78 FR 64199 - Fisheries of the South Atlantic; South Atlantic Fishery Management Council; Public Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2013-10-28

... Council, 4055 Faber Place Drive, Suite 201, N. Charleston, SC 29405. FOR FURTHER INFORMATION CONTACT: Kim Iverson, Public Information Officer, 4055 Faber Place Drive, Suite 201, North Charleston, SC 29405...

Finite-size effects in Monte Carlo simulations of two stock market models

NASA Astrophysics Data System (ADS)

Egenter, E.; Lux, T.; Stauffer, D.

The microscopic market models of Kim-Markowitz and of Lux-Marchesi are simulated for varying number of investors. If this number goes to infinity, in some quantities nearly periodic oscillations occur.

[Effects of death anxiety and meaning of life on somatization of grandparent raising grandchildren].

PubMed

Kim, Se-Young

2015-04-01

This study was conducted in order to examine the effects of death anxiety and meaning of life on somatization of grandparents raising grandchildren. A convenience sample of 92 elderly grandparents raising grandchildren was recruited. The study instrument for death anxiety was the 5-point 15 items scale designed by Templer and translated by Ko, Choi, & Lee and for meaning of life, the 7-point 10-items scale by Steger, Frazier, Oishi & Kaler and translated by Won, Kim & Kwon. For somatization, the 5-point 12 items scale designed by Derogatis and translated by Kim, Kim & Won was used. Collected data were analyzed with descriptive statistics, independent t-test, one-way ANOVA, Pearson Correlation and regression using the SPSS 21.0 program. Average scores were 3.55 for death anxiety, 3.43 for meaning of life, and 2.74 for somatization. Death anxiety had the highest positive correlation with somatization. Meaning of life was negatively correlated with death anxiety and somatization. Death anxiety and health status were shown to influence somatization but meaning of life was not shown to influence somatization. The research results indicate that death anxiety and health status influence somatization in grandparents raising grandchildren. These results also provide basic information on the importance of nursing interventions in which the variables influencing somatization in grandparents raising grandchildren are considered.

Metabolic Syndrome and Cardio-Cerebrovascular Risk Disparities Between Pilots and Aircraft Mechanics.

PubMed

Kim, Myeong-Bo; Kim, Hyun-Jin; Kim, Soo-Hyeon; Lee, Suk-Ho; Lee, Se-Ho; Park, Won-Ju

2017-09-01

In the Republic of Korea Air Force, the health of pilots is strictly supervised, but there is comparatively not enough interest in aircraft mechanics' health. Among mechanics, who are heavily involved in military aircraft maintenance, the occurrence of sudden cardio-cerebrovascular diseases (CCVDs) is a possible risk factor during the maintenance process, which should be performed perfectly. We performed health examinations on 2123 male aircraft pilots and 1271 aircraft mechanics over 30 yr of age and determined the prevalence of metabolic syndrome (MetS), an important risk factor for CCVDs. The prevalence of MetS in the aircraft mechanics (21.3%) was significantly higher than in the pilots (12.6%), and the gap in prevalence tended to grow as age increased. Among aircraft mechanics in their 30s and 40s, the prevalence of MetS was lower than in the general population. However, the prevalence of MetS among aircraft mechanics in their 50s (36.0%) was similar to that in the general population (35.7%). Systematic health management is needed for aircraft mechanics for aviation safety and for the maintenance of military strength via the prevention of CCVDs.Kim M-B, Kim H-J, Kim S-H, Lee S-H, Lee S-H, Park W-J. Metabolic syndrome and cardio-cerebrovascular risk disparities between pilots and aircraft mechanics. Aerosp Med Hum Perform. 2017; 88(9):866-870.

A Second Look: "Captains Courageous."

ERIC Educational Resources Information Center

Kimmel, Eric A.

1982-01-01

Notes how the internal structure of Rudyard's "The Jungle Book,""Captains Courageous," and "Kim," are all the same, even though "Captains Courageous" is not as widely acclaimed as the other two books. (HOD)

Peregrine Rocket Motor Test at the Ames Outdoor Aerodynamic Rese

NASA Image and Video Library

2017-02-15

(Left): Kyle Botteon (front) and Hunjpp Kim (Behind), NASA JPL. (Right): Gregory Zilliac, Advance Propulsion Technician. NASA Ames, preparing the Peregrine Hybrid Rocket Engine at the Outdoor Aerodynamic Research Facility (OARF, N-249).

Validation of newly developed and redesigned key indicator methods for assessment of different working conditions with physical workloads based on mixed-methods design: a study protocol.

PubMed

Klussmann, Andre; Liebers, Falk; Brandstädt, Felix; Schust, Marianne; Serafin, Patrick; Schäfer, Andreas; Gebhardt, Hansjürgen; Hartmann, Bernd; Steinberg, Ulf

2017-08-21

The impact of work-related musculoskeletal disorders is considerable. The assessment of work tasks with physical workloads is crucial to estimate the work-related health risks of exposed employees. Three key indicator methods are available for risk assessment regarding manual lifting, holding and carrying of loads; manual pulling and pushing of loads; and manual handling operations. Three further KIMs for risk assessment regarding whole-body forces, awkward body postures and body movement have been developed de novo. In addition, the development of a newly drafted combined method for mixed exposures is planned. All methods will be validated regarding face validity, reliability, convergent validity, criterion validity and further aspects of utility under practical conditions. As part of the joint project MEGAPHYS (multilevel risk assessment of physical workloads), a mixed-methods study is being designed for the validation of KIMs and conducted in companies of different sizes and branches in Germany. Workplaces are documented and analysed by observations, applying KIMs, interviews and assessment of environmental conditions. Furthermore, a survey among the employees at the respective workplaces takes place with standardised questionnaires, interviews and physical examinations. It is intended to include 1200 employees at 120 different workplaces. For analysis of the quality criteria, recommendations of the COSMIN checklist (COnsensus-based Standards for the selection of health Measurement INstruments) will be taken into account. The study was planned and conducted in accordance with the German Medical Professional Code and the Declaration of Helsinki as well as the German Federal Data Protection Act. The design of the study was approved by ethics committees. We intend to publish the validated KIMs in 2018. Results will be published in peer-reviewed journals, presented at international meetings and disseminated to actual users for practical application. © Article

Proximal renal tubular injury in rats sub-chronically exposed to low fluoride concentrations

DOE Office of Scientific and Technical Information (OSTI.GOV)

Cárdenas-González, Mariana C.; Del Razo, Luz M.; Barrera-Chimal, Jonatan

2013-11-01

Fluoride is usually found in groundwater at a very wide range of concentration between 0.5 and 25 ppm. At present, few studies have assessed the renal effects of fluoride at environmentally relevant concentrations. Furthermore, most of these studies have used insensitive and nonspecific biomarkers of kidney injury. The aim of this study was to use early and sensitive biomarkers to evaluate kidney injury after fluoride exposure to environmentally relevant concentrations. Recently weaned male Wistar rats were exposed to low (15 ppm) and high (50 ppm) fluoride concentrations in drinking water for a period of 40 days. At the end ofmore » the exposure period, kidney injury biomarkers were measured in urine and renal mRNA expression levels were assessed by real time RT-PCR. Our results showed that the urinary kidney injury molecule (Kim-1), clusterin (Clu), osteopontin (OPN) and heat shock protein 72 excretion rate significantly increased in the group exposed to the high fluoride concentration. Accordingly, fluoride exposure increased renal Kim-1, Clu and OPN mRNA expression levels. Moreover, there was a significant dose-dependent increase in urinary β-2-microglobulin and cystatin-C excretion rate. Additionally, a tendency towards a dose dependent increase of tubular damage in the histopathological light microscopy findings confirmed the preferential impact of fluoride on the tubular structure. All of these changes occurred at early stages in which, the renal function was not altered. In conclusion using early and sensitive biomarkers of kidney injury, we were able to found proximal tubular alterations in rats sub-chronically exposed to fluoride. - Highlights: • Exposure to low concentrations of fluoride induced proximal tubular injury • Increase in urinary Kim-1, Clu, OPN and Hsp72 in 50 ppm fluoride-exposed group • Increase in urinary B2M and CysC in 15 and 50 ppm fluoride-exposed groups • Fluoride exposure increased renal Kim, Clu and OPN mRNA expression

Patient-specific evolution of renal function in chronic heart failure patients dynamically predicts clinical outcome in the Bio-SHiFT study.

PubMed

Brankovic, Milos; Akkerhuis, K Martijn; van Boven, Nick; Anroedh, Sharda; Constantinescu, Alina; Caliskan, Kadir; Manintveld, Olivier; Cornel, Jan Hein; Baart, Sara; Rizopoulos, Dimitris; Hillege, Hans; Boersma, Eric; Umans, Victor; Kardys, Isabella

2018-04-01

Renal dysfunction is an important component of chronic heart failure (CHF), but its single assessment does not sufficiently reflect clinically silent progression of CHF prior to adverse clinical outcome. Therefore, we aimed to investigate temporal evolutions of glomerular and tubular markers in 263 stable patients with CHF, and to determine if their patient-specific evolutions during this clinically silent period can dynamically predict clinical outcome. We determined the risk of clinical outcome (composite endpoint of Heart Failure hospitalization, cardiac death, Left Ventricular Assist Device placement, and heart transplantation) in relation to marker levels, slopes and areas under their trajectories. In each patient, the trajectories were estimated using repeatedly measured glomerular markers: creatinine/estimated glomerular filtration rate (eGFR), cystatin C (CysC), and tubular markers: urinary N-acetyl-beta-D-glucosaminidase (NAG) and kidney injury molecule (KIM)-1, plasma and urinary neutrophil gelatinase-associated lipocalin (NGAL). During 2.2 years of follow-up, we collected on average 8 urine and 9 plasma samples per patient. All glomerular markers predicted the endpoint (univariable hazard ratio [95% confidence interval] per 20% increase: creatinine: 1.18[1.07-1.31], CysC: 2.41[1.81-3.41], and per 20% eGFR decrease: 1.13[1.05-1.23]). Tubular markers, NAG, and KIM-1 also predicted the endpoint (NAG: 1.06[1.01-1.11] and KIM-1: 1.08[1.04-1.11]). Larger slopes were the strongest predictors (creatinine: 1.57[1.39-1.84], CysC: 1.76[1.52-2.09], eGFR: 1.59[1.37-1.90], NAG: 1.26[1.11-1.44], and KIM-1: 1.64[1.38-2.05]). Associations persisted after multivariable adjustment for clinical characteristics. Thus, during clinically silent progression of CHF, glomerular and tubular functions deteriorate, but not simultaneously. Hence, patient-specific evolutions of these renal markers dynamically predict clinical outcome in patients with CHF. Copyright © 2017

Determining appropriate imaging parameters for kilovoltage intrafraction monitoring: an experimental phantom study

NASA Astrophysics Data System (ADS)

Wallace, D.; Ng, J. A.; Keall, P. J.; O'Brien, R. T.; Poulsen, P. R.; Juneja, P.; Booth, J. T.

2015-06-01

Kilovoltage intrafraction monitoring (KIM) utilises the kV imager during treatment for real-time tracking of prostate fiducial markers. However, its effectiveness relies on sufficient image quality for the fiducial tracking task. To guide the performance characterisation of KIM under different clinically relevant conditions, the effect of different kV parameters and patient size on image quality, and quantification of MV scatter from the patient to the kV detector panel were investigated in this study. Image quality was determined for a range of kV acquisition frame rates, kV exposure, MV dose rates and patient sizes. Two methods were used to determine image quality; the ratio of kV signal through the patient to the MV scatter from the patient incident on the kilovoltage detector, and the signal-to-noise ratio (SNR). The effect of patient size and frame rate on MV scatter was evaluated in a homogeneous CIRS pelvis phantom and marker segmentation was determined utilising the Rando phantom with embedded markers. MV scatter incident on the detector was shown to be dependent on patient thickness and frame rate. The segmentation code was shown to be successful for all frame rates above 3 Hz for the Rando phantom corresponding to a kV to MV ratio of 0.16 and an SNR of 1.67. For a maximum patient dimension less than 36.4 cm the conservative kV parameters of 5 Hz at 1 mAs can be used to reduce dose while retaining image quality, where the current baseline kV parameters of 10 Hz at 1 mAs is shown to be adequate for marker segmentation up to a patient dimension of 40 cm. In conclusion, the MV scatter component of image quality noise for KIM has been quantified. For most prostate patients, use of KIM with 10 Hz imaging at 1 mAs is adequate however image quality can be maintained and imaging dose reduced by altering existing acquisition parameters.

The association between whole body sagittal balance and risk of falls among elderly patients seeking treatment for back pain.

PubMed

Kim, J; Hwang, J Y; Oh, J K; Park, M S; Kim, S W; Chang, H; Kim, T-H

2017-05-01

The objective of this study was to assess the association between whole body sagittal balance and risk of falls in elderly patients who have sought treatment for back pain. Balanced spinal sagittal alignment is known to be important for the prevention of falls. However, spinal sagittal imbalance can be markedly compensated by the lower extremities, and whole body sagittal balance including the lower extremities should be assessed to evaluate actual imbalances related to falls. Patients over 70 years old who visited an outpatient clinic for back pain treatment and underwent a standing whole-body radiograph were enrolled. Falls were prospectively assessed for 12 months using a monthly fall diary, and patients were divided into fallers and non-fallers according to the history of falls. Radiological parameters from whole-body radiographs and clinical data were compared between the two groups. A total of 144 patients (120 female patients and 24 male patients) completed a 12-month follow-up for assessing falls. A total of 31 patients (21.5%) reported at least one fall within the 12-month follow-up. In univariate logistic regression analysis, the risk of falls was significantly increased in older patients and those with more medical comorbidities, decreased lumbar lordosis, increased sagittal vertical axis, and increased horizontal distance between the C7 plumb line and the centre of the ankle (C7A). Increased C7A was significantly associated with increased risk of falls even after multivariate adjustment. Whole body sagittal balance, measured by the horizontal distance between the C7 plumb line and the centre of the ankle, was significantly associated with risk of falls among elderly patients with back pain. Cite this article : J. Kim, J. Y. Hwang, J. K. Oh, M. S. Park, S. W. Kim, H. Chang, T-H. Kim. The association between whole body sagittal balance and risk of falls among elderly patients seeking treatment for back pain. Bone Joint Res 2017;6:-344. DOI: 10

Genetics Home Reference: Muenke syndrome

MedlinePlus

... Muenke syndrome Sources for This Page Agochukwu NB, Solomon BD, Muenke M. Impact of genetics on the ... Hadley DW, Brewer C, Zalewski C, Kim HJ, Solomon B, Rosenbaum K, Domingo DL, Hart TC, Brooks ...

78 FR 39713 - Determination Under the Textile and Apparel Commercial Availability Provision of the Dominican...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-07-02

...). Weight: 220-315 grams per square meter. Thread Count (Density): 76-110 ends per inch (Warp) X 70-90 picks.... Finishing Processes: Airjet Dyed. Kim Glas, Chairman Committee for the Implementation of Textile Agreements...

76 FR 71584 - Notice of Revocation of Customs Broker Licenses

Federal Register 2010, 2011, 2012, 2013, 2014

2011-11-18

... Antonelli Joseph 04804 New York Rosenberg Edward 02869 New York Kim Haingduck 16243 New York Solomon Julius... 17090 New York Digena Stephanie 16624 New York Four Corners, Inc 16691 New York Juliussen Ellen 15497...

Genetics Home Reference: Larsen syndrome

MedlinePlus

... active (expressed) in the cell membranes of cartilage-forming cells (chondrocytes). Cartilage is a tough, flexible tissue ... Alanay Y, Alembik Y, Al-Madani N, Firth H, Karimi-Nejad MH, Kim CA, Leask K, Maisenbacher ...

Gaming and Religion: The Impact of Spirituality and Denomination.

PubMed

Braun, Birgit; Kornhuber, Johannes; Lenz, Bernd

2016-08-01

A previous investigation from Korea indicated that religion might modulate gaming behavior (Kim and Kim in J Korean Acad Nurs 40:378-388, 2010). Our present study aimed to investigate whether a belief in God, practicing religious behavior and religious denomination affected gaming behavior. Data were derived from a Western cohort of young men (Cohort Study on Substance Use Risk Factors, n = 5990). The results showed that a stronger belief in God was associated with lower gaming frequency and smaller game addiction scale scores. In addition, practicing religiosity was related to less frequent online and offline gaming. Finally, Christians gamed less frequently and had lower game addiction scale scores than subjects without religious denomination. In the future, these results could prove useful in developing preventive and therapeutic strategies for the Internet gaming disorder.

Multicomponent phase-field model for extremely large partition coefficients

DOE Office of Scientific and Technical Information (OSTI.GOV)

Welland, Michael J.; Wolf, Dieter; Guyer, Jonathan E.

2014-01-01

We develop a multicomponent phase-field model specially formulated to robustly simulate concentration variations from molar to atomic magnitudes across an interlace, i.e., partition coefficients in excess of 10±23 such as may be the case with species which are predominant in one phase and insoluble in the other. Substitutional interdiffusion on a normal lattice and concurrent interstitial diffusion are included. The composition in the interlace follows the approach of Kim. Kim, and Suzuki [Phys. Rev. E 60, 7186 (1999)] and is compared to that of Wheeler, Boettinger, and McFadden [Phys. Rev. A 45, 7424 (1992)] in the context of large partitioning.more » The model successfully reproduces analytical solutions for binary diffusion couples and solute trapping for the demonstrated cases of extremely large partitioning.« less

Considering the Future of Pharmaceutical Promotions in Social Media Comment on "Trouble Spots in Online Direct-to-Consumer Prescription Drug Promotion: A Content Analysis of FDA Warning Letters".

PubMed

Carpentier, Francesca Renee Dillman

2016-02-09

This commentary explores the implications of increased social media marketing by drug manufacturers, based on findings in Hyosun Kim's article of the major themes in recent Food and Drug Administration (FDA) warning letters and notices of violation regarding online direct-to-consumer promotions of pharmaceuticals. Kim's rigorous analysis of FDA letters over a 10-year span highlights a relative abundance of regulatory action toward marketer-controlled websites and sponsored advertisements, compared to branded and unbranded social media messaging. However, social media marketing efforts are increasing, as is FDA attention to these efforts. This commentary explores recent developments and continuing challenges in the FDA's attempts to provide guidance and define pharmaceutical company accountability in marketer-controlled and -uncontrolled claims disseminated through social media. © 2016 by Kerman University of Medical Sciences.

Pertussis

MedlinePlus

... Kim DK, Riley LE, Harriman KH, Hunter P, Bridges CB. Advisory Committee on Immunization Practices recommended immunization ... commercial use must be authorized in writing by ADAM Health Solutions. About MedlinePlus Site Map FAQs Customer ...

Development of Bottom-Up Chemical Approaches to 3-D Negative Index Meta-Materials: Two Photon Lithographic Approach-Chiral Chemical Synthesis Approach

DTIC Science & Technology

2014-06-30

2014). 15. F. Alali, Y.H. Kim, A. Baev, E.P Furlani, "Plasmon-enhanced Metasurfaces for Controlling Optical Polarization," ACS Photonics 1(6), 507-515 (2014). DISTRIBUTION A: Distribution approved for public release.

Loss of brain function - liver disease

MedlinePlus

... FF, ed. Ferri's Clinical Advisor 2018 . Philadelphia, PA: Elsevier; 2018:577-579. Garcia-Tsao G. Cirrhosis and ... eds. Goldman-Cecil Medicine . 25th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 153. Jakhete N, Kim AK. ...

Cervical dysplasia

MedlinePlus

... 24264713 www.ncbi.nlm.nih.gov/pubmed/24264713 . Kim DK, Bridges CB, Harriman KH; Centers for Disease ... techniques, management. In: Lentz GM, Lobo RA, Gershenson DM, Katz VL, eds. Comprehensive Gynecology . 6th ed. Philadelphia, ...

Goiter - simple

MedlinePlus

... In: Jameson JL, De Groot LJ, de Kretser DM, et al, eds. Endocrinology: Adult and Pediatric . 7th ed. Philadelphia, PA: Elsevier Saunders; 2016:chap 90. Kim M, Ladenson PW. Thyroid. In: Goldman L, Schafer ...

Celebrities Gather to Fight Heart Disease

MedlinePlus

... Kimberly Guilfoyle Villency, Kim Cattrall, Katharine McPhee, Sheila Johnson, Danica Patrick, Angela Bassett, Mae Jemison, Lauren Hutton, ... Matlin, Zuleyka Rivera, Natalie Morales, Helena Christensen, Betsey Johnson, Kelly Ripa, Kristin Chenoweth, Billie Jean King, Jane ...

Genetics Home Reference: tubular aggregate myopathy

MedlinePlus

... in both type I and type II fibers, forming clumps of tube-like structures called tubular aggregates. ... Hyun C, Woo JS, Park CS, Kim do H, Lee EH. Stromal interaction molecule 1 (STIM1) regulates ...

VizieR Online Data Catalog: ChaMP X-ray point source catalog (Kim+, 2007)

NASA Astrophysics Data System (ADS)

Kim, M.; Kim, D.-W.; Wilkes, B. J.; Green, P. J.; Kim, E.; Anderson, C. S.; Barkhouse, W. A.; Evans, N. R.; Ivezic, Z.; Karovska, M.; Kashyap, V. L.; Lee, M. G.; Maksym, P.; Mossman, A. E.; Silverman, J. D.; Tananbaum, H. D.

2009-01-01

We present the Chandra Multiwavelength Project (ChaMP) X-ray point source catalog with ~6800 X-ray sources detected in 149 Chandra observations covering ~10deg2. The full ChaMP catalog sample is 7 times larger than the initial published ChaMP catalog. The exposure time of the fields in our sample ranges from 0.9 to 124ks, corresponding to a deepest X-ray flux limit of f0.5-8.0=9x10-16ergs/cm2/s. The ChaMP X-ray data have been uniformly reduced and analyzed with ChaMP-specific pipelines and then carefully validated by visual inspection. The ChaMP catalog includes X-ray photometric data in eight different energy bands as well as X-ray spectral hardness ratios and colors. To best utilize the ChaMP catalog, we also present the source reliability, detection probability, and positional uncertainty. (10 data files).

Systemically Applied Insecticides for Treatment of Erythrina Gall Wasp, Quadrastichus erythrinae Kim (Hymenoptera: Eulophidae)

Treesearch

Joseph J. Doccola; Sheri L. Smith; Brian L. Strom; Arthur C. Medeiros; Erica von Allmen

2009-01-01

The erythrina gall wasp (EGW), believed native to Africa, is a recently described species and now serious invasive pest of Erythrina (coral trees) in tropical and subtropical locales. Erythrina are favored ornamental and landscape trees, as well as native members of threatened ecosystems. The EGW is a tiny, highly mobile, highly invasive wasp that deforms (galls) host...

Systemically applied insecticides for treatment of erythrina gall wasp, quadrastichus erythrinae kim hymenoptera: Eulophidae

USGS Publications Warehouse

Doccola, J.J.; Smith, S.L.; Strom, B.L.; Medeiros, A.C.; Von Allmen, E.

2009-01-01

Abstract The erythrina gall wasp (EGW), believed native to Africa, is a recently described species and now serious invasive pest of Erythrina (coral trees) in tropical and subtropical locales. Erythrina are favored ornamental and landscape trees, as well as native members of threatened ecosystems. The EGW is a tiny, highly mobile, highly invasive wasp that deforms (galls) host trees causing severe defoliation and tree death. The first detection of EGW in the United States was in O'ahu, Hawai'i in April 2005. It quickly spread through the Hawai'ian island chain (U.S.) killing ornamental and native Erythrina in as little as two years. At risk are endemic populations of Erythrinaas well as ornamental landscape species in the same genus, the latter of which have already been killed and removed from O'ahu at a cost of more than USD $1 million. Because EGW are so small and spread so quickly, host injury is usually detected before adult wasps are observed, making prophylactic treatments less likely than therapeutic ones. This study evaluates two stem-injected insecticides, imidacloprid (IMA-jet??) and emamectin benzoate, delivered through Arborjet Tree I.V.?? equipment, for their ability to affect E. sandwicensis (wiliwili) canopy demise under severe EGW exposure. IMA-jet, applied at a rate of 0.16 g AI/cm basal diameter (0.4 g AI/in. dia.), was the only effective treatment for maintaining canopy condition of wiliwili trees. Emamectin benzoate, applied at a rate of -0.1 g AI/cm basal diameter (-0.25 g AI/in. dia.), was not effective in this application, although it was intermediate in effect between IMA-jet and untreated trees. The relatively high concentrations of imidacloprid in leaves, and its durability for at least 13 months in native wiliwili growing on a natural, dryland site, suggest that treatment applications against EGW can impact canopy recovery even under suboptimal site and tree conditions. ?? 2009 International Society of Arboriculture.

The Russian National Character as Self-Represented in Humor (A Sociological Analysis of Anecdotes)

ERIC Educational Resources Information Center

Zubanova, L. V.

2014-01-01

The analysis of Russian humor shows that perceptions of Russian cultural traits, social structure, and history can be perpetuated and reproduced in ways that are politically and socially safe. [This article was translated by Kim Braithwaite.

Wesley Jones | NREL

Science.gov Websites

, W.B.; Kim, K. (2009). "A Note on the Virtual Crystal Approach to Alloy Optimization." BioEnergy Science Center Laboratory Information Management System (LIMS); Korytina, D.; Graf, P.A.; King, R

Genetics Home Reference: dopamine beta-hydroxylase deficiency

MedlinePlus

... deficiency Sources for This Page Cubells JF, Zabetian CP. Human genetics of plasma dopamine beta-hydroxylase activity: ... 16. Review. Citation on PubMed Kim CH, Zabetian CP, Cubells JF, Cho S, Biaggioni I, Cohen BM, Robertson ...

78 FR 13342 - Ocean Transportation Intermediary License Applicants

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-27

... License. Air Sea Land Shipping & Moving Inc. (NVO & OFF), 211 East 43rd Street, Suite 1206, New York, NY...), 11205 S. La Cienega Blvd.,Los Angeles, CA 90045. Officers: Kirk Kim, Secretary (QI), Woo B. Lim...

Ocean Drilling Program: TAMRF Administrative Services: Human Resources

Science.gov Websites

/TAMRF Human Resources For updated policies and forms, see the IODP-USIO Human Resources web site. For additional information contact: Kim Johnson Supervisor of Human Resources and Insurance Services Ocean

Ephedra

MedlinePlus

... Audio) NCCIH Clinical Digest A monthly newsletter with evidence-based information on complementary and integrative practices and a ... Kim EJ, Chen Y, Huang JQ, et al. Evidence-based toxicity evaluation and scheduling of Chinese herbal medicines. ...

Genetics Home Reference: spondylocarpotarsal synostosis syndrome

MedlinePlus

... active (expressed) in the cell membranes of cartilage-forming cells (chondrocytes). Cartilage is a tough, flexible tissue ... D, Shapiro SS, Takafuta T, Aftimos S, Kim CA, Firth H, Steiner CE, Cormier-Daire V, Superti-Furga A, ...

1300038

NASA Image and Video Library

2013-01-28

FROM LEFT TO RIGHT IN FRONT OF THE F-1 GAS GENERATOR ARE: DYNETICS PROGRAM MANAGER KIM DOERING, DYNETICS DEPUTY PROGRAM MANAGER ANDY CROCKER, MARSHALL PARTNERSHIPS MANAGER STACY COUNTS, AND MARSHALL PROJECT MANAGER FOR DYNETICS WHITNEY YOUNG.

ARC-2007-ACD07-0073-050

NASA Image and Video Library

2007-04-14

Lunar CRater Observation and Sensing Satellite (LCROSS) and P.I. at NASA Ames Research Center - Total Luminance Photometer lens and electronics units on shake table in N-2444 EEL Laboratory: Kim Ennico and Gi Kojima check electronics

Peregrine Rocket Motor Test at the Ames Outdoor Aerodynamic Rese

NASA Image and Video Library

2017-02-15

Ashley Karp, NASA JPL (Left) and Hunjoo Kim, NASA JPL (Right) attaching heat sensors the Peregrine Hybrid Rocket Engine prior to its test at the Outdoor Aerodynamic Research Facility (OARF, N-249) at NASA's Ames Research Center.

Dexamethasone Modifies Cystatin C-Based Diagnosis of Acute Kidney Injury During Cisplatin-Based Chemotherapy.

PubMed

Pianta, Timothy J; Pickering, John W; Succar, Lena; Chin, Melvin; Davidson, Trent; Buckley, Nicholas A; Mohamed, Fahim; Endre, Zoltan H

2017-01-01

Plasma cystatin C (pCysC) may be superior to serum creatinine (sCr) as a surrogate of GFR. However, the performance of pCysC for diagnosing acute kidney injury (AKI) after cisplatin-based chemotherapy is potentially affected by accompanying corticosteroid anti-emetic therapy and hydration. In a prospective observational study pCysC, sCr, urinary kidney injury molecule-1 (KIM-1), and urinary clusterin were measured over 2 weeks in 27 patients given first-cycle chemotherapy. The same variables were measured over 2 weeks in Sprague-Dawley rats given a single intraperitoneal injection of dexamethasone, cisplatin, or both, and in controls. In patients, pCysC increases were greater than sCr 41% vs. 16%, mean paired difference 25% (95% CI: 16-34%)], relative increases were ≥ 50% in 9 patients (35%) for pCysC compared with 2 (8%) for sCr (p = 0.04) and increases in sCr were accompanied by increased KIM-1 and clusterin excretion, but increases in pCysC alone were not. In rats, dexamethasone administration produced dose-dependent increases in pCysC (and augmented cisplatin-induced increases in pCysC), but did not augment histological injury, increases in sCr, or KIM-1 and clusterin excretion. In the presence of dexamethasone, elevation of pCysC does not reliably diagnose AKI after cisplatin-based chemotherapy. © 2017 The Author(s)Published by S. Karger AG, Basel.

A Hero's Little Horse: Discovery of a Dissolving Star Cluster in Pegasus

NASA Astrophysics Data System (ADS)

Kim, Dongwon; Jerjen, Helmut

2015-01-01

We report the discovery of an ultra-faint stellar system in the constellation of Pegasus. This concentration of stars was detected by applying our overdensity detection algorithm to the Sloan Digital Sky Survey Data Release 10 and confirmed with deeper photometry from the Dark Energy Camera (DECam) at the 4 m Blanco telescope. The best-fitting model isochrone indicates that this stellar system, Kim 1, features an old (12 Gyr) and metal-poor ([Fe/H] ~ -1.7) stellar population at a heliocentric distance of 19.8 ± 0.9 kpc. We measure a half-light radius of 6.9 ± 0.6 pc using a Plummer profile. The small physical size and the extremely low luminosity are comparable to the faintest known star clusters Segue 3, Koposov 1 and 2, and Muñoz 1. However, Kim 1 exhibits a lower star concentration and is lacking a well-defined center. It also has an unusually high ellipticity and irregular outer isophotes, which suggests that we are seeing an intermediate mass star cluster being stripped by the Galactic tidal field. An extended search for evidence of an associated stellar stream within the 3 \\deg 2 DECam field remains inconclusive. The finding of Kim 1 is consistent with current overdensity detection limits and supports the hypothesis that there are still a substantial number of extreme low-luminosity star clusters undetected in the wider Milky Way halo.

Elevated urinary levels of kidney injury molecule-1 among Chinese factory workers exposed to trichloroethylene

PubMed Central

Vermeulen, Roel; Huang, Hanlin; Rothman, Nathaniel; Lan, Qing

2012-01-01

Epidemiological studies suggest that trichloroethylene (TCE) exposure may be associated with renal cancer. The biological mechanisms involved are not exactly known although nephrotoxicity is believed to play a role. Studies on TCE nephrotoxicity among humans, however, have been largely inconsistent. We studied kidney toxicity in Chinese factory workers exposed to TCE using novel sensitive nephrotoxicity markers. Eighty healthy workers exposed to TCE and 45 comparable unexposed controls were included in the present analyses. Personal TCE exposure measurements were taken over a 2-week period before urine collection. Ninety-six percent of workers were exposed to TCE below the current US Occupational Safety and Health Administration permissible exposure limit (100 ppm 8h TWA), with a mean (SD) of 22.2 (35.9) ppm. Kidney injury molecule-1 (KIM-1) and Pi-glutathione S transferase (GST) alpha were elevated among the exposed subjects as compared with the unexposed controls with a strong exposure-response association between individual estimates of TCE exposure and KIM-1 (P < 0.0001). This is the first report to use a set of sensitive nephrotoxicity markers to study the possible effects of TCE on the kidneys. The findings suggest that at relatively low occupational exposure levels a toxic effect on the kidneys can be observed. This finding supports the biological plausibility of linking TCE exposure and renal cancer. Abbreviations:GSTglutathione-S-transferaseKIM-1kidney injury molecule-1NAGN-acetyl-beta-(d)-glucosaminidaseOVMorganic vapour monitoringTCEtrichloroethyleneVEGFvascular endothelial growth factor. PMID:22665366

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, Dongwon; Jerjen, Helmut, E-mail: dongwon.kim@anu.edu.au, E-mail: helmut.jerjen@anu.edu.au

We report the discovery of an ultra-faint stellar system in the constellation of Pegasus. This concentration of stars was detected by applying our overdensity detection algorithm to the Sloan Digital Sky Survey Data Release 10 and confirmed with deeper photometry from the Dark Energy Camera (DECam) at the 4 m Blanco telescope. The best-fitting model isochrone indicates that this stellar system, Kim 1, features an old (12 Gyr) and metal-poor ([Fe/H] ∼ -1.7) stellar population at a heliocentric distance of 19.8 ± 0.9 kpc. We measure a half-light radius of 6.9 ± 0.6 pc using a Plummer profile. The small physicalmore » size and the extremely low luminosity are comparable to the faintest known star clusters Segue 3, Koposov 1 and 2, and Muñoz 1. However, Kim 1 exhibits a lower star concentration and is lacking a well-defined center. It also has an unusually high ellipticity and irregular outer isophotes, which suggests that we are seeing an intermediate mass star cluster being stripped by the Galactic tidal field. An extended search for evidence of an associated stellar stream within the 3 deg{sup 2} DECam field remains inconclusive. The finding of Kim 1 is consistent with current overdensity detection limits and supports the hypothesis that there are still a substantial number of extreme low-luminosity star clusters undetected in the wider Milky Way halo.« less

Development and Application of In Vitro Models for Screening Drugs and Environmental Chemicals that Predict Toxicity in Animals and Humans

EPA Pesticide Factsheets

Development and Application of In Vitro Models for Screening Drugs and Environmental Chemicals that Predict Toxicity in Animals and Humans (Presented by James McKim, Ph.D., DABT, Founder and Chief Science Officer, CeeTox) (5/25/2012)

Priority Tasks of the Development of a Regional Higher Pedagogical Educational Institution

ERIC Educational Resources Information Center

Shilov, S. P.

2014-01-01

Regional higher pedagogical educational institutions in Russia need to use new techniques in preparing students for new social and economic needs, including providing more opportunities for engagement in practical research experiences. [This article was translated by Kim Braithwaite.

Peregrine Rocket Motor Test at the Ames Outdoor Aerodynamic Rese

NASA Image and Video Library

2017-02-15

Hunjoo Kim, NASA JPL (Left) and Ashley Karp, NASA JPL (Right) attaching heat sensors the Peregrine Hybrid Rocket Engine prior to its test at the Outdoor Aerodynamic Research Facility (OARF, N-249) at NASA’s Ames Research Center.

The signalling of German rising-falling intonation categories--the interplay of synchronization, shape, and height.

PubMed

Niebuhr, Oliver

2007-01-01

Based on the phonology of the Kiel Intonation Model (KIM), a tripartite opposition of German intonation is investigated: early, medial, and late peaks. These intonation categories, which can be projected onto H + L*, H*, and L* + H in the AM framework, are described in the KIM as rising-falling F(0) peak patterns differentiated by their synchronization with the accented-vowel onset. Perception experiments were carried out, showing that the function-based identification of the peak categories is not only influenced by peak synchronization, but also by peak shape and height. While the complete spectrum of findings is not covered by the current phonological modelling, the findings corroborate the existence of all three categories in German intonation and support the idea that the timing of the peak movements with regard to the accented vowel is important for their perceptual differentiation.

Recruitment and Recommendation of College Students: North Korea.

DTIC Science & Technology

1960-09-14

Journalism, Chinese Literat- ure, Library Science , Russian Language and Literature, Geology, Geodesic Chart Science (Ch’ukchi Chldohak), Planning...History, Philosophy, Library Science , Politi- cal Economy, and Meteorological ^um.unhak/. (f) The Preparatory School for Honor Soldiers. 2. Kim

All Scientists Meeting

ScienceCinema

Pier Oddone and Young-Kee Kim

2018-04-17

Pier Oddone and Young-Kee Kim of Fermi National Accelerator Laboratory lead an all-scientists meeting to discuss current and future work, scope of research, budget and funding information, and other information relating to the lab and its scientists.

COMPARISON OF MONODISPERSE AND POLYDISPERSE AEROSOL DEPOSITION IN A PACKED BED

EPA Science Inventory

COMPARISON OF MONODISPERSE AND POLYDISPERSE AEROSOL DEPOSITION IN A PACKED BED. Jacky A. Rosati, Dept. of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, NC 27599; Chong S. Kim, USEPA National Health and Environmental Effects Research Laboratory...

Test Rover Sinks into Prepared Soil

NASA Image and Video Library

2009-06-30

While a test rover rolls off a plywood surface into a prepared bed of soft soil, rover team members Colette Lohr left and Kim Lichtenberg center eye the wheels digging into the soil and Paolo Bellutta enters the next driving command.

Decarbonisation strategies : how much, how, where and who pays for [delta] [less than or equal-to] 2* Celsius?

DOT National Transportation Integrated Search

2010-03-01

This paper was written for the conference presidential address delivered on January 23 2010 at the 40th Annual : Meeting of the Gujarat Economic Association in Kim (Surat District), India. The paper has been motivated primarily to outline and : delve...

DEPOSITION DISTRICUTION AMONG THE PARALLEL PATHWAYS IN THE HUMAN LUNG CONDUCTING AIRWAY STRUCTURE.

EPA Science Inventory

DEPOSITION DISTRIBUTION AMONG THE PARALLEL PATHWAYS IN THE HUMAN LUNG CONDUCTING AIRWAY STRUCTURE. Chong S. Kim*, USEPA National Health and Environmental Effects Research Lab. RTP, NC 27711; Z. Zhang and C. Kleinstreuer, Department of Mechanical and Aerospace Engineering, North C...

ANALYSIS OF RESPIRATORY DESPOSITION DOSE OF INHALED AMBIENT AEROSOLS FOR DIFFERENT SIZE FRACTIONS

EPA Science Inventory

ANALYSIS OF RESPIRATORY DEPOSITION DOSE OF INHALED AMBIENT AEROSOLS FOR DIFFERENT SIZE FRACTIONS. Chong S. Kim, SC. Hu**, PA Jaques*, US EPA, National Health and Environmental Effects Research Laboratory, Research Triangle Park, NC 27711; **IIT Research Institute, Chicago, IL; *S...

Social Support and Acculturative Stress among Korean International Students

ERIC Educational Resources Information Center

Ra, Young-An

2016-01-01

Previous studies have reported that international students in the US experience unique difficulties and acculturative stress related to cultural differences, language barriers, academic pressure, and interpersonal relationships (Mallinckrodt & Leong, 1992). Berry, Kim, Minde, and Mok (1987) defined this "acculturative stress" as…

TRANSPORT AND DEPOSITION OF NANO-SIZE PARTICLES IN THE UPPER HUMAN RESPIRATORY AIRWAYS

EPA Science Inventory

TRANSPORT AND DEPOSITION OF NANO-SIZE PARTICLES IN THE UPPER HUMAN RESPIRATORY AIRWAYS. Zhe Zhang*, Huawei Shi, Clement Kleinstreuer, Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC 27695-7910; Chong S. Kim, National Health and En...

Bile culture

MedlinePlus

Culture - bile ... is placed in a special dish called a culture medium to see if bacteria, viruses, or fungi ... Chernecky CC, Berger BJ. Body fluid - anaerobic culture. In: ... . 6th ed. St Louis, MO: Elsevier Saunders; 2013:225-226. Kim AY, ...

ANALYSIS OF RESPIRATORY DEPOSITION OF INHALED AMBIENT AEROSOLS FOR DIFFERENT DOSE METRICS

EPA Science Inventory

ANALYSIS OF RESPIRATORY DEPOSITION OF INHALED AMBIENT AEROSOLS FOR DIFFERENT DOSE METRICS.
Chong S. Kim, SC. Hu**, PA Jaques*, US EPA, National Health and Environmental Effects Research Laboratory, Research Triangle Park, NC 27711; **IIT Research Institute, Chicago, IL; *South...

Artificial intelligence expert systems with neural network machine learning may assist decision-making for extractions in orthodontic treatment planning.

PubMed

Takada, Kenji

2016-09-01

New approach for the diagnosis of extractions with neural network machine learning. Seok-Ki Jung and Tae-Woo Kim. Am J Orthod Dentofacial Orthop 2016;149:127-33. Not reported. Mathematical modeling. Copyright © 2016 Elsevier Inc. All rights reserved.

What Moscow's Schoolteachers Think about the Reform of the Modern School

ERIC Educational Resources Information Center

Gasparishvili, A. T.; Kruzhalin, V. I.; Krukhmaleva, O. V.

2014-01-01

Survey research on the opinions of Moscow's schoolteachers concerning changes in secondary education shows a lack of consensus on the reforms, and a far less positive view than that of planners and officials. [This article was translated by Kim Braithwaite.

The Role of Education in the Sociocultural Adaptation of Migrants

ERIC Educational Resources Information Center

Panina, G. V.

2014-01-01

If conflicts and other problems are to be reduced, the ethnic and cultural diversity of Russian society related to migration requires the creation of a new educational environment based on the modern interpretation of multiculturalism. [This article was translated by Kim Braithwaite.

ARC-2008-ACD08-0196-015

NASA Image and Video Library

2008-09-07

NASA Day at AT&T Park: NASA and the San Francisco Giants share a day to celebrate the 50 year anniversaries. Ames New Ventures and Communication staff (L-R) Dolores Beasley, Lori and Kim Newton enjoy the sun and fun at the game.

ARC-2008-ACD07-0073-499

NASA Image and Video Library

2008-01-18

LCROSS leaves Northrup Grumman Redondo Beach, CA clean room post shippment verification tests before being mated to the Lunar Reconnaissance Orbitor (LR0) spacecraft for a piggyback ride to the Moon. With Kim Ennico Ames P.I. and Mark Shirley, Northrup Grumman.

76 FR 59416 - Senior Executive Service Performance Review Board

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-26

... Anderson, Gary Anderson, Penny Andrews, John Armstrong, Charles R. Armstrong, Sue Athmann, Ronald Ayala, Janice Barber, Delores Baroukh, Nader Bartoldus, Charles Bathurst, Donald Bauhs, Kim Beagles, James... Butcher, Michael Button, Christopher Byrne, Michael Byrne, Sean J. Cahill, Donna L. Callahan, Mary Ellen...

KSC-2014-2938

NASA Image and Video Library

2014-06-09

CAPE CANAVERAL, Fla. – John Elbon, The Boeing Company's vice president general manager of Boeing Space Systems, discusses the CST-100 spacecraft during a ceremony inside Orbiter Processing Facility 3 at NASA's Kennedy Space Center in Florida. Photo credit: NASA/Kim Shiflett

KSC-2012-5020

NASA Image and Video Library

2012-09-12

CAPE CANAVERAL, Fla. – Henry Taylor is the chief flight engineer on the Shuttle Carrier Aircraft, or SCA, that will take space shuttle Endeavour from NASA's Kennedy Space Center in Florida to Los Angeles for public display. Photo credit: NASA/Kim Shiflett

MATHEMATICAL ANALYSIS OF PARTICLE TRANSPORT AND DEPOSITION IN HUMAN LUNGS

EPA Science Inventory

MATHEMATICAL ANALYSIS OF PARTICLE TRANSPORT AND DEPOSITION IN HUMAN LUNGS. Jung-il Choi*, Center for Environmental Medicine, University of North Carolina, Chapel Hill, NC 27599; C. S. Kim, USEPA National Health and Environmental Effects Research Lab. RTP, NC 27711

Partic...

Cervical dermatome overlap: frequently forgotten in search of a clear answer.

PubMed

Bible, Jesse E

2016-01-01

Rainville J, Laxer E, Keel J, Pena E, Kim D, Milam RA, et al. Exploration of sensory impairments associated with C6 and C7 radiculopathies. Spine J 2016:16:49-54 (in this issue). Copyright © 2015 Elsevier Inc. All rights reserved.

Graphene Synthesis and Characterization

DTIC Science & Technology

2015-04-08

for synthesis electrochemical. - A Scanning Electron Microscope (SEM) (EVO MA from Carl Zeiss). 6 6. RESULTS AND...5, 2332-2339, 2011, High-Quality Thin graphene films from fast electrochemical exfoliation. [13] Da Hee Jung , Cheong Kang, Ji Eun Nam, Jin-Seok Kim

AEROSOL DEPOSITION EFFICIENCIES AND UPSTREAM RELEASE POSITIONS FOR DIFFERENT INHALATION MODES IN AN UPPER BRONCHIAL AIRWAY MODELS

EPA Science Inventory

Aerosol Deposition Efficiencies and Upstream Release Positions for Different Inhalation Modes in an Upper Bronchial Airway Model

Zhe Zhang, Clement Kleinstreuer, and Chong S. Kim

Center for Environmental Medicine and Lung Biology, University of North Carolina at Ch...

KSC-2012-5028

NASA Image and Video Library

2012-09-12

CAPE CANAVERAL, Fla. - A row of posters displays some of the history of the Shuttle Carrier Aircraft, or SCA, that will take space shuttle Endeavour from NASA's Kennedy Space Center in Florida to Los Angeles for public display. Photo credit: NASA/Kim Shiflett

KSC-2011-1305

NASA Image and Video Library

2011-01-29

CAPE CANAVERAL, Fla. -- The Astronaut Scholarship Foundation helps celebrate the 40th anniversary of Apollo 14's lunar landing, which occurred Feb. 5, 1971, with a soiree at the Kennedy Space Center Visitor Complex's Saturn V Center. Photo credit: NASA/Kim Shiflett

New Concepts in Electromagnetic Materials and Antennas

DTIC Science & Technology

2015-01-01

Bae-Ian Wu Antennas & Electromagnetics Technology Branch Multispectral Sensing & Detection Division JANUARY 2015 Final Report...Signature// //Signature// BRADLEY A. KRAMER, Program Manager TONY C. KIM, Branch Chief Antenna & Electromagnetic Technology ...Branch Antenna & Electromagnetic Technology Branch Multispectral Sensing & Detection Division Multispectral Sensing & Detection Division

KSC-2011-1440

NASA Image and Video Library

2011-02-14

CAPE CANAVERAL, Fla. -- At NASA's Kennedy Space Center in Florida, Center Director Bob Cabana speaks to the local media about the FY 2012 budget during an informal briefing held in the TV studio at the Press Site. Photo credit: NASA/Kim Shiflett

KSC-2011-1441

NASA Image and Video Library

2011-02-14

CAPE CANAVERAL, Fla. -- At NASA's Kennedy Space Center in Florida, Center Director Bob Cabana speaks to the local media about the FY 2012 budget during an informal briefing held in the TV studio at the Press Site. Photo credit: NASA/Kim Shiflett

California Psychological Inventory Dominance Scale Measurement Equivalence: General Population Normative and Indian, U.K., and U.S. Managerial Samples

ERIC Educational Resources Information Center

Kulas, John T.; Thompson, Richard C.; Anderson, Michael G.

2011-01-01

The California Psychological Inventory's Dominance scale was investigated for inconsistencies in item-trait associations across four samples (one American normative and three culturally dissociated manager groupings). The Kim, Cohen, and Park procedure was used, enabling simultaneous multigroup comparison in addition to the traditional…

RESPIRATORY DOSE TO SUSCEPTIBLE POPULATIONS ASSESSED BY EXPOSURE AND DOSIMETRY STUDIES

EPA Science Inventory

Respiratory Dose to Susceptible Populations Assessed by Exposure and Dosimetry Studies

Chong Kim1 and Ronald Williams2, 1USEPA National Health and Environmental Effects Research Laboratory and 2USEPA National Exposure Research Laboratory, RTP, NC.

Rationale: Parti...

SIGNALING MECHANISMS IN HUMAN AIRWAY EPITHELIAL CELLS EXPOSED TO CARBON ULTRAFINE PARTICLES

EPA Science Inventory

SIGNALING MECHANISMS IN HUMAN AIRWAY EPITHELIAL CELLS EXPOSED TO CARBON ULTRAFINE PARTICLES
Y.M. Kim, A.G. Lenz, R. Silbajoris, I. Jaspers and J.M. Samet. Department of Environmental Sciences and Engineering and Center for Environmental Medicine, University of North Carolina, ...

ANALYSIS OF RESPIRATORY DEPOSITION OF INHALED PARTICLES FOR DIFFERENT DOSE METRICS: COMPARISON OF NUMBER, SURFACE AREA AND MASS DOSE OF TYPICAL AMBIENT BI-MODAL AEROSOLS

EPA Science Inventory

ANALYSIS OF RESPIRATORY DEPOSITION OF INHALED PARTICLES FOR DIFFERENT DOSE METRICS: COMPARISON OF NUMBER, SURFACE AREA AND MASS DOSE OF TYPICAL AMBIENT BI-MODAL AEROSOLS.
Chong S. Kim, SC. Hu*, PA Jaques*, US EPA, National Health and Environmental Effects Research Laboratory, ...

Peregrine Rocket Motor Test at the Ames Outdoor Aerodynamic Rese

NASA Image and Video Library

2017-02-15

From Left to Right: Ashley Karp (NASA JPL), Hunjoo Kim (NASA JPL), Brian Schratz (NASA JPL) and Kyle Botteon (NASA JPL) Testing the Peregrine Hybrid Rocket Engine at the Outdoor Aerodynamic Research Facility (building N249, OARF) at NASA’s Ames Research Center.

Protective role of testosterone in ischemia-reperfusion-induced acute kidney injury

PubMed Central

Soljancic, Andrea; Ruiz, Arnaldo Lopez; Chandrashekar, Kiran; Maranon, Rodrigo; Liu, Ruisheng; Juncos, Luis A.

2013-01-01

Men are at greater risk for renal injury and dysfunction after acute ischemia-reperfusion (I/R) than are women. Studies in animals suggest that the reason for the sex difference in renal injury and dysfunction after I/R is the protective effect of estrogens in females. However, a reduction in testosterone in men is thought to play an important role in mediating cardiovascular and renal disease, in general. In the present study, we tested the hypothesis that I/R of the kidney reduces serum testosterone, and that contributes to renal dysfunction and injury. Male rats that were subjected to renal ischemia of 40 min followed by reperfusion had a 90% reduction in serum testosterone by 3 h after reperfusion that remained at 24 h. Acute infusion of testosterone 3 h after reperfusion attenuated the increase in plasma creatinine and urinary kidney injury molecule-1 (KIM-1) at 24 h, prevented the reduction in outer medullary blood flow, and attenuated the increase in intrarenal TNF-α and the decrease in intrarenal VEGF at 48 h. Castration of males caused greater increases in plasma creatinine and KIM-1 at 24 h than in intact males with renal I/R, and treatment with anastrozole, an aromatase inhibitor, plus testosterone almost normalized plasma creatinine and KIM-1 in rats with renal I/R. These data show that renal I/R is associated with sustained reductions in testosterone, that testosterone repletion protects the kidney, whereas castration promotes renal dysfunction and injury, and that the testosterone-mediated protection is not conferred by conversion to estradiol. PMID:23552495

Mitochondrial JNK activation triggers autophagy and apoptosis and aggravates myocardial injury following ischemia/reperfusion.

PubMed

Xu, Jie; Qin, Xinghua; Cai, Xiaoqing; Yang, Lu; Xing, Yuan; Li, Jun; Zhang, Lihua; Tang, Ying; Liu, Jiankang; Zhang, Xing; Gao, Feng

2015-02-01

c-Jun N-terminal kinase (JNK) is a stress-activated mitogen-activated protein kinase that plays a central role in initiating apoptosis in disease conditions. Recent studies have shown that mitochondrial JNK signaling is partly responsible for ischemic myocardial dysfunction; however, the underlying mechanism remains unclear. Here we report for the first time that activation of mitochondrial JNK, rather than JNK localization on mitochondria, induces autophagy and apoptosis and aggravates myocardial ischemia/reperfusion injury. Myocardial ischemia/reperfusion induced a dominant increase of mitochondrial JNK phosphorylation, while JNK mitochondrial localization was reduced. Treatment with Tat-SabKIM1, a retro-inverso peptide which blocks JNK interaction with mitochondria, decreased mitochondrial JNK activation without affecting JNK mitochondrial localization following reperfusion. Tat-SabKIM1 treatment reduced Bcl2-regulated autophagy, cytochrome c-mediated apoptosis and myocardial infarct size. Notably, selective inhibition of mitochondrial JNK activation using Tat-SabKIM1 produced a similar infarct size-reducing effect as inhibiting universal JNK activation with JNK inhibitor SP600125. Moreover, insulin-treated animals exhibited significantly dampened mitochondrial JNK activation accompanied by reduced infarct size and diminished autophagy and apoptosis following reperfusion. Taken together, these findings demonstrate that mitochondrial JNK activation, rather than JNK mitochondrial localization, induces autophagy and apoptosis and exacerbates myocardial ischemia/reperfusion injury. Insulin selectively inhibits mitochondrial JNK activation, contributing to insulin cardioprotection against myocardial ischemic/reperfusion injury. This article is part of a Special Issue entitled: Autophagy and protein quality control in cardiometabolic diseases. Copyright © 2014 Elsevier B.V. All rights reserved.

Titan's Thermal Emission: Analysis Of Near-surface Temperatures Via Mid-infrared Measurements

NASA Astrophysics Data System (ADS)

Sadino, Jeff; Parrish, P. D.; Orton, G. S.; Burl, M. C.; Davies, A. G.; Irwin, P. G.; Teanby, N. A.; Flasar, F. M.; Cassini/CIRS investigation Team

2006-09-01

After Courtin and Kim 2002, tropospheric and near-surface temperatures of Titan may be obtained by examining mid-infrared radiances at 300 and 500 wavenumbers (33 and 20 microns). Here, the measured radiance is (respectively) sensitive to the temperature near the tropopause and sufficient to discern variations in surface topography and emissivity. Our search, as a function of location and time, compares brightness temperatures derived from measurements by the Cassini Composite Infrared Spectrometer (CIRS) and variations of radiance as a function of Titan's rotation derived from ground-based measurements at NASA's Infrared Telescope Facility. Although the variation of the tropopause and zonal near-surface temperatures are fairly homogenous, similar to Courtin and Kim 2002, the meridional distribution of near-surface temperatures varies symmetrically from Equator to pole. While no significant thermal variations suggestive of localized hotspots have yet been observed, such diversity is suggestive of active surface geology, in support of other optical and near-infrared investigations. Although the spatial coverage of the CIRS dataset is severely limited, the approximately 10 degrees field of view (450km at the Equator) is de-convolved somewhat to extract meaningful, sub-pixel maps of Titan's surface. Courtin, R. and Kim, S. (2002). Planet. and Sp. Sci., 50: 309-321. The acquisition of data described here was accomplished through the coordinated effort of Cassini-Huygens project staff, Deep Space Network personnel and the CIRS instrument and science-planning teams with funding provided by the National Research Council, NASA/JPL and NASA/GSFC and the UK Particle Physics and Astronomy council.

Oral administration of a recombinant attenuated Yersinia pseudotuberculosis strain elicits protective immunity against plague.

PubMed

Sun, Wei; Sanapala, Shilpa; Rahav, Hannah; Curtiss, Roy

2015-11-27

A Yersinia pseudotuberculosis PB1+ (Yptb PB1+) mutant strain combined with chromosome insertion of the caf1R-caf1A-caf1M-caf1 operon and deletions of yopJ and yopK, χ10068 [pYV-ω2 (ΔyopJ315 ΔyopK108) ΔlacZ044::caf1R-caf1M-caf1A-caf1] was constructed. Results indicated that gene insertion and deletion did not affect the growth rate of χ10068 compared to wild-type Yptb cultured at 26 °C. In addition, the F1 antigen in χ10068 was synthesized and secreted on the surface of bacteria at 37 °C (mammalian body temperature), not at ambient culture temperature (26 °C). Immunization with χ10068 primed antibody responses and specific T-cell responses to F1 and YpL (Y. pestis whole cell lysate). Oral immunization with a single dose of χ10068 provided 70% protection against a subcutaneous (s.c.) challenge with ∼ 2.6 × 10(5) LD50 of Y. pestis KIM6+ (pCD1Ap) (KIM6+Ap) and 90% protection against an intranasal (i.n.) challenge with ∼ 500 LD50 of KIM6+Ap in mice. Our results suggest that χ10068 can be used as an effective precursor to make a safe vaccine to prevent plague in humans and to eliminate plague circulation among humans and animals. Copyright © 2015 Elsevier Ltd. All rights reserved.

Harnessing an RNA-mediated chaperone for the assembly of influenza hemagglutinin in an immunologically relevant conformation.

PubMed

Yang, Seung Won; Jang, Yo Han; Kwon, Soon Bin; Lee, Yoon Jae; Chae, Wonil; Byun, Young Ho; Kim, Paul; Park, Chan; Lee, Young Jae; Kim, Choon Kang; Kim, Young Seok; Choi, Seong Il; Seong, Baik Lin

2018-05-01

A novel protein-folding function of RNA has been recognized, which can outperform previously known molecular chaperone proteins. The RNA as a molecular chaperone (chaperna) activity is intrinsic to some ribozymes and is operational during viral infections. Our purpose was to test whether influenza hemagglutinin (HA) can be assembled in a soluble, trimeric, and immunologically activating conformation by means of an RNA molecular chaperone (chaperna) activity. An RNA-interacting domain (RID) from the host being immunized was selected as a docking tag for RNA binding, which served as a transducer for the chaperna function for de novo folding and trimeric assembly of RID-HA1. Mutations that affect tRNA binding greatly increased the soluble aggregation defective in trimer assembly, suggesting that RNA interaction critically controls the kinetic network in the folding/assembly pathway. Immunization of mice resulted in strong hemagglutination inhibition and high titers of a neutralizing antibody, providing sterile protection against a lethal challenge and confirming the immunologically relevant HA conformation. The results may be translated into a rapid response to a new influenza pandemic. The harnessing of the novel chaperna described herein with immunologically tailored antigen-folding functions should serve as a robust prophylactic and diagnostic tool for viral infections.-Yang, S. W., Jang, Y. H., Kwon, S. B., Lee, Y. J., Chae, W., Byun, Y. H., Kim, P., Park, C., Lee, Y. J., Kim, C. K., Kim, Y. S., Choi, S. I., Seong, B. L. Harnessing an RNA-mediated chaperone for the assembly of influenza hemagglutinin in an immunologically relevant conformation.

A mouse diversity panel approach reveals the potential for clinical kidney injury due to DB289 not predicted by classical rodent models.

PubMed

Harrill, Alison H; Desmet, Kristina D; Wolf, Kristina K; Bridges, Arlene S; Eaddy, J Scott; Kurtz, C Lisa; Hall, J Ed; Paine, Mary F; Tidwell, Richard R; Watkins, Paul B

2012-12-01

DB289 is the first oral drug shown in clinical trials to have efficacy in treating African trypanosomiasis (African sleeping sickness). Mild liver toxicity was noted but was not treatment limiting. However, development of DB289 was terminated when several treated subjects developed severe kidney injury, a liability not predicted from preclinical testing. We tested the hypothesis that the kidney safety liability of DB289 would be detected in a mouse diversity panel (MDP) comprised of 34 genetically diverse inbred mouse strains. MDP mice received 10 days of oral treatment with DB289 or vehicle and classical renal biomarkers blood urea nitrogen (BUN) and serum creatinine (sCr), as well as urine biomarkers of kidney injury were measured. While BUN and sCr remained within reference ranges, marked elevations were observed for kidney injury molecule-1 (KIM-1) in the urine of sensitive mouse strains. KIM-1 elevations were not always coincident with elevations in alanine aminotransferase (ALT), suggesting that renal injury was not linked to hepatic injury. Genome-wide association analyses of KIM-1 elevations indicated that genes participating in cholesterol and lipid biosynthesis and transport, oxidative stress, and cytokine release may play a role in DB289 renal injury. Taken together, the data resulting from this study highlight the utility of using an MDP to predict clinically relevant toxicities, to identify relevant toxicity biomarkers that may translate into the clinic, and to identify potential mechanisms underlying toxicities. In addition, the sensitive mouse strains identified in this study may be useful in screening next-in-class compounds for renal injury.

Role of bicarbonate supplementation on urine uric acid crystals and diabetic tubulopathy in adults with type 1 diabetes.

PubMed

Bjornstad, Petter; Maahs, David M; Roncal, Carlos A; Snell-Bergeon, Janet K; Shah, Viral N; Milagres, Tamara; Ellis, Samuel L; Hatch, Matthew; Chung, Linh T; Rewers, Marian J; Garg, Satish; Cherney, David Z; Pyle, Laura; Nadeau, Kristen J; Johnson, Richard J

2018-07-01

Uricosuria and crystallization are increasingly recognized risk factors for diabetic tubulopathy. This pilot clinical trial aimed to determine the acute effect of urinary alkalinization using oral sodium bicarbonate (NaHCO 3 ) on UA crystals in adults with type 1 diabetes (T1D). Adults with T1D, ages 18 to 65 years (n = 45, 60% female, HbA1c, 7.5 ± 1.2%, 20.2 ± 9.3 years duration) without chronic kidney disease (eGFR ≥60 mL/min/1.73 m 2 and albumin-to-creatinine ratio < 30 mg/g) received 2 doses of 1950 mg oral NaHCO 3 over 24 hours. Fasting urine and serum were collected pre- and post-intervention. UA crystals were identified under polarized microscopy. Urine measurements included: osmolality, pH, UA, creatinine and kidney injury molecule-1 (KIM-1). NaHCO 3 therapy increased mean ± SD urine pH from 6.1 ± 0.7 to 6.5 ± 0.7 (P < .0001). Prior to therapy, 31.0% of participants had UA crystals vs 6.7% post therapy (P = .005). Change in urine pH inversely correlated with change in urine KIM-1 (r:-0.51, P = .0003). In addition, change in urine UA over 24 hours correlated with change in urine KIM-1 (r:0.37, P = .01). In conclusion, oral NaHCO 3 normalized urine pH and decreased UA crystals, and may hold promise as an inexpensive and safe tubulo-protective intervention in individuals with T1D. © 2018 John Wiley & Sons Ltd.

Development of Computational Simulation Tools to Model Weapon Propulsors

DTIC Science & Technology

2004-01-01

Calculation in Permanent Magnet Motors with Rotor Eccentricity: With Slotting Effect Considered," IEEE Transactions on Magnetics, Volume 34, No. 4, 2253-2266...1998). [3] Lieu, Dennis K., Kim, Ungtae. "Magnetic Field Calculation in Permanent Magnet Motors with Rotor Eccentricity: Without Slotting Effect

Tick Surveillance of Small Mammals Captured in Gyeonggi and Gangwon Provinces, Republic of Korea, 2004-2008

DTIC Science & Technology

2010-07-30

number of zoonotic pathogens: spotted fever group rickettsiae (Lee et al. 2003), Ehrlichia and Anaplasma spp. (Chae et al. 2003), Bartonella spp. (Kim...K.H. & Lee, S.H. (2003) Identification of the spotted fever group rickettsiae detected from Haemaphysalis longicornis in Korea. Microbiology and

Ranking Different Stakeholder-Driven Definitions of Academic Quality

ERIC Educational Resources Information Center

Shouba, Derek

2017-01-01

Americans are increasingly concerned about academic quality (Hauptman & Kim, 2009). This concern about academic quality is a product of the relative decline of the American economy, American Program for International Student Assessment (PISA) test scores, American baccalaureate attainment rates, and various other indicators of national…

75 FR 61507 - National Heart, Lung, and Blood Institute; Notice of Closed Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2010-10-05

... Blood Institute; Notice of Closed Meetings Pursuant to section 10(d) of the Federal Advisory Committee... clearly unwarranted invasion of personal privacy. Name of Committee: National Heart, Lung, and Blood... Kim, PhD, Scientific Review Officer, Review Branch, DERA, National Heart, Lung, and Blood Institute...

78 FR 75948 - Senior Executive Service; Appointment of Members to the Performance Review Board

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-13

... Resources Center--Sydney T. Rose Executive Secretary--Director, Executive Resources--Kim L.H. Green... H. Moore, Deputy Assistant Secretary for Operations and Analysis--appointment expires on 09/30/16..., New York--appointment expires on 09/30/16 OLMS Stephen J. Willertz, Director, Office of Enforcement...

76 FR 16459 - Prohibiting Exports Involving Libya by Executive Order

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-23

... NUCLEAR REGULATORY COMMISSION [NRC-2011-0064] Prohibiting Exports Involving Libya by Executive... prohibits any nuclear exports involving the Government of Libya. FOR FURTHER INFORMATION CONTACT: Grace Kim... of Libya Suspended by Executive Order Under an Executive Order issued by the President on February 25...

MICROWAVE-ASSISTED PREPARATION OF CYCLIC UREAS FROM DIAMINES

EPA Science Inventory

Rajender S. Varma* and Yong-Jin Kim
Cyclic ureas are useful intermediates for a variety of pharmaceuticals and pesticides. One of the attractive approaches for the synthesis of cyclic ureas uses condensation of diamines with urea as a carbonyl source under dynamic evacuation. ...

Refining an Automated Transcranial Doppler System for the Detection of Vasospasm after Traumatic Brain Injury

DTIC Science & Technology

2015-11-01

examples of paired physiology and ultrasound models are given by Rune Aaslid and David H Evans. Aaslid offers [19] a sophisticated but proprietary... Rune Aaslid commercial software avalible from http://www.transcranial.com/ [20] Sunghan Kim, Mateo Aboy, James McNames, Pulse pressure variation

Optimization of In-Cylinder Pressure Filter for Engine Research

DTIC Science & Technology

2017-06-01

ARL-TR-8034 ● JUN 2017 US Army Research Laboratory Optimization of In-Cylinder Pressure Filter for Engine Research by Kenneth...Laboratory Optimization of In-Cylinder Pressure Filter for Engine Research by Kenneth S Kim, Michael T Szedlmayer, Kurt M Kruger, and Chol-Bum M...

77 FR 62490 - Performance Review Board Appointments

Federal Register 2010, 2011, 2012, 2013, 2014

2012-10-15

...; Gutter, Karis T.; Harden, Krysta.; Hipp, Janie; Holtzman, Max T.; Jett, Carole E.; Jones, Carmen....; Chasteen, G. Taylor; Christian, Lisa A.; Clanton, Michael W.; Coffee, Richard; Farington, Kim S.; Foster....; Watts, Michael; White, John S.; White, Sharmian L.; Wilburn, Curtis; Wilusz, Lisa; Young, Benjamin...

KSC-07pd0007

NASA Image and Video Library

2007-01-03

KENNEDY SPACE CENTER, FLA. -- A handshake signifies the change of leadership at NASA's Kennedy Space Center as William W. Parsons (left) assumes the role as the facility's ninth director, succeeding James W. Kennedy (right), who is retiring from the agency. Photo credit: NASA/Kim Shiflett

Transformer Specification Language: A System for Generating Analyzers and Its Applications

DTIC Science & Technology

2011-01-01

like to thank present and former colleagues in PL group, Evan Driscoll, Aditya Thakur, Matt Elder, Tushar Sharma , Prathmesh Prabhu, Tycho Andersen, Emma...Robert Cohn, Robert Muth, Harish Patil, Artur Klauser, Geoff Lowney, Steven Wallace, Vijay Janapa Reddi, and Kim Hazelwood. Pin: building customized

76 FR 65699 - South Atlantic Fishery Management Council; Public Meetings

Federal Register 2010, 2011, 2012, 2013, 2014

2011-10-24

... Director, South Atlantic Fishery Management Council, 4055 Faber Place Drive, Suite 201, North Charleston..., 4055 Faber Place Drive, Suite 201, North Charleston, SC 29405; telephone: (843) 571-4366 or toll free.... FOR FURTHER INFORMATION CONTACT: Kim Iverson, South Atlantic Fishery Management Council, 4055 Faber...

Peregrine Rocket Motor Test at the Ames Outdoor Aerodynamic Rese

NASA Image and Video Library

2017-02-15

From Left to Right: 1. Hunjoo Kim (NASA JPL) 2. Kyle Botteon (NASA JPL) 3. Ashley Karp (NASA JPL) 4. Brian Schratz (NASA JPL) Testing the Peregrine Hybrid Rocket Engine at the Outdoor Aerodynamic Research Facility (building N249, OARF) at Ames Research Center.

EXTENSION OF SELF-MODELING CURVE RESOLUTION TO MIXTURES OF MORE THAN THREE COMPONENTS: PART 2: FINDING THE COMPLETE SOLUTION. (R826238)

EPA Science Inventory

The previous paper [R.C. Henry, B.M. Kim, Extension of self-modeling curve resolution to mixtures of more than three components: Part 1. Finding the basic feasible region, Chemometrics and Intelligent Laboratory Systems 8 (1990) 205_¯216] explained an extension ...

Can Universities Encourage Students' Continued Motivation for Knowledge Sharing and How Can This Help Organizations?

ERIC Educational Resources Information Center

Shoemaker, Nikki

2014-01-01

Both practitioners and researchers recognize the increasing importance of knowledge sharing in organizations (Bock, Zmud, Kim, & Lee, 2005; Vera-Muñoz, Ho, & Chow, 2006). Knowledge sharing influences a firm's knowledge creation, organizational learning, performance achievement, growth, and competitive advantage (Bartol &…

Proceedings of the Annual Meeting of the Association for Education in Journalism and Mass Communication (86th, Kansas City, Missouri, July 30-August 2, 2003). Newspaper Division.

ERIC Educational Resources Information Center

2003

The Newspaper Division of the proceedings contains the following 22 papers: "Framing Freedom: Hoosier Republican and Democratic Newspaper Editors Frame Lincoln's Emancipation Proclamation" (David W. Bulla); "Quantifying Newspaper Quality: 'I Know It When I See It'" (Philip Meyer and Koang-Hyub Kim); "Cultural Convergence:…

A Comparison of the PRIME-MD PHQ-9 and PHQ-8 in a Large Military Prospective Study, the Millennium Cohort Study

DTIC Science & Technology

2013-03-14

2007. Smallpox vaccination: comparison of self-reported and electronic vaccine records in the Millennium Cohort Study. Human. Vaccine 3, 6. Oquendo...Kim, H.M., McCarthy, J.F., Austin, K.L., Hoggatt, K.J., Walters, H., Valenstein, M., 2007. Suicide mortality among individuals receiving treatment

Fusions of Breast Carcinoma and Dendritic Cells as a Vaccine for the Treatment of Metastatic Breast Cancer

DTIC Science & Technology

2005-07-01

Morris, L. S., Coleman, N., and Alexander, G. J. Compromised lymphocytes infiltrate hepatocellular carcinoma : the role of T-regulatory cells...regulatory T cells in peripheral blood of patients with hepatocellular carcinoma . Cancer Res., 65: 2457-2464, 2005. 18. Schaefer, C., Kim, G. G., Albers, A

Research-Based Design of Pedagogical Agent Roles: A Review, Progress, and Recommendations

ERIC Educational Resources Information Center

Kim, Yanghee; Baylor, Amy L.

2016-01-01

In this paper we review the contribution of our original work titled "Simulating Instructional Roles Through Pedagogical Agents" published in the "International Journal of Artificial Intelligence and Education" (Baylor and Kim in "Computers and Human Behavior," 25(2), 450-457, 2005). Our original work operationalized…

77 FR 41453 - Submission for OMB Review, Comment Request, Proposed Collection: General Clearance for Guidelines...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-13

... of Museum and Library Services, National Foundation for the Arts and Humanities. ACTION: Submission for OMB Review, Comment Request. SUMMARY: The Institute of Museum and Library Services announces the... responses. ADDRESSES: Kim A. Miller, Management Analyst, Institute of Museum and Library Services, 1800 M...

Coherent Control of Diamond Defects for Quantum Information Science and Quantum Sensing

DTIC Science & Technology

2014-04-18

beam steering in micromirror systems [192]. Furthermore, by eliminating require- ments for cryogenic temperatures, our blueprint aims to make the...Isenhower, A. T. Gill, F. P. Lu, M. Saffman, and J. Kim. Independent individual addressing of multiple neutral atom qubits with a micromirror -based

North Korea’s Provocation and Escalation Calculus: Dealing with the Kim Jong-un Regime

DTIC Science & Technology

2015-08-01

regime. “The Interview” In the early 2000s, Seth Rogan and Evan Goldberg conceived of a plot for a comic take on the assassination of a world...responsible for the education and training of the regime’s cyber warriors.55  The State Security Department’s (secret police) communications monitoring and...is young and lacks the expansive and deep education his father had before taking the reins of power. This has created a certain narrative in the

VizieR Online Data Catalog: Low-resolution near-infrared stellar spectra from CIBER (Kim+, 2017)

NASA Astrophysics Data System (ADS)

Kim, M. G.; Lee, H. M.; Arai, T.; Bock, J.; Cooray, A.; Jeong, W.-S.; Kim, S. J.; Korngut, P.; Lanz, A.; Lee, D. H.; Lee, M. G.; Matsumoto, T.; Matsuura, S.; Nam, U. W.; Onishi, Y.; Shirahata, M.; Smidt, J.; Tsumura, K.; Yamamura, I.; Zemcov, M.

2017-06-01

We present flux-calibrated near-infrared spectra of 105 stars from 0.8{<=}λ{<=}1.8μm with spectral resolution 15{<=}λ/Δλ{<=}30 over the range. The Low-Resolution Spectrometer (LRS) is one of the four optical instruments of the Cosmic Infrared Background Experiment (CIBER) payload; the others are a narrowband spectrometer and two wide-field imagers. The LRS is a prism-dispersed spectrometer with five rectangular 5.35°*2.8' slits imaging a 5.8°*5.8° field of view. The detector has 256*256 pixels at a pixel scale of 1.36'*1.36'. CIBER has flown four times (2009 February, 2010 July, 2012 March, and 2013 June) with apogees and total exposure times of over 325km and ~240s, respectively, in the first three flights and of 550km and 335s in the final, non-recovered flight. Due to spurious signal contamination from thermal emission from the shock-heated rocket skin, we do not use the first flight data in this work. The star spectral types are determined by fitting known spectral templates to the measured LRS spectra. We use the Infrared Telescope Facility (IRTF) and Pickles 1998 (Cat. J/PASP/110/863) templates for the SED fitting. The SpeX instrument installed on the IRTF observed stars using a medium-resolution spectrograph (R=2000). The template library contains spectra for 210 cool stars (F to M type) with wavelength coverage from 0.8 to 2.5μm (Cushing 2005ApJ...623.1115C; Rayner 2009ApJS..185..289R). The Pickles library is a synthetic spectral library that combines spectral data from various observations to achieve wavelength coverage from the UV (0.115μm) to the near-infrared (2.5μm). It contains 131 spectral templates for all star types (i.e., O to M type) with a uniform sampling interval of 5Å. (6 data files).

Ashea megacephala Kim & Ahn (Coleoptera, Staphylinidae, Aleocharinae), a new gyrophaenine genus and species from Peru.

PubMed

Kim, Yoon-Ho; Ahn, Kee-Jeong

2015-01-01

Ashea megacephala, a new Peruvian genus and species is described. The specimens were collected on mushrooms and mushroom-associated trees. This genus can be readily distinguished from the other genera of the subtribe Gyrophaenina by the large head and the three indistinctly articulated labial palpomeres. A key to the known genera of Gyrophaenina is provided. A habitus photograph and illustrations of diagnostic characters are also presented.

VizieR Online Data Catalog: ChaMP. I. First X-ray source catalog (Kim+, 2004)

NASA Astrophysics Data System (ADS)

Kim, D.-W.; Cameron, R. A.; Drake, J. J.; Evans, N. R.; Freeman, P.; Gaetz, T. J.; Ghosh, H.; Green, P. J.; Harnden, F. R. Jr; Karovska, M.; Kashyap, V.; Maksym, P. W.; Ratzlaff, P. W.; Schlegel, E. M.; Silverman, J. D.; Tananbaum, H. D.; Vikhlinin, A. A.; Wilkes, B. J.; Grimes, J. P.

2004-01-01

The Chandra Multiwavelength Project (ChaMP) is a wide-area (~14deg2 < survey of serendipitous Chandra X-ray sources, aiming to establish fair statistical samples covering a wide range of characteristics (such as absorbed active galactic nuclei, high-z clusters of galaxies) at flux levels (fX~10-15 to 10-14erg/s/cm2) ) intermediate between the Chandra deep surveys and previous missions. We present the first ChaMP catalog, which consists of 991 near on-axis, bright X-ray sources obtained from the initial sample of 62 observations. The data have been uniformly reduced and analyzed with techniques specifically developed for the ChaMP and then validated by visual examination. To assess source reliability and positional uncertainty, we perform a series of simulations and also use Chandra data to complement the simulation study. The false source detection rate is found to be as good as or better than expected for a given limiting threshold. On the other hand, the chance of missing a real source is rather complex, depending on the source counts, off-axis distance (or PSF), and background rate. The positional error (95% confidence level) is usually less than 1" for a bright source, regardless of its off-axis distance, while it can be as large as 4" for a weak source (~20counts) at a large off-axis distance (Doff-axis>8'). We have also developed new methods to find spatially extended or temporary variable sources, and those sources are listed in the catalog. (5 data files).

The Influence of Supplementary Professional Education on the Position of Workers of Various Social and Professional Groups

ERIC Educational Resources Information Center

Popova, I. P.

2011-01-01

Russia's new economy and changes in the technological and employment spheres require the continual retraining of Russian workers and professionals. Research shows that there are benefits of this for individuals and for the society. (Contains 4 tables and 5 notes.) [This article was translated by Kim Braithwaite.

A Brief Note on Evidence-Centered Design as a Mechanism for Assessment Development and Evaluation

ERIC Educational Resources Information Center

Bond, Lloyd

2014-01-01

Lloyd Bond comments here on the Focus article in this issue of "Measurement: Interdisciplinary Research and Perspectives". The Focus article is entitled: "How Task Features Impact Evidence from Assessments Embedded in Simulations and Games" (Russell G. Almond, Yoon Jeon Kim, Gertrudes Velasquez, and Valerie J. Shute). Bond…

77 FR 40059 - Findings of Research Misconduct

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-06

... DEPARTMENT OF HEALTH AND HUMAN SERVICES Office of the Secretary Findings of Research Misconduct... Research Integrity (ORI) has taken final action in the following case: Sinae Kim, Ph.D., Emory University..., Department of Medicine, EU, engaged in research misconduct in research supported by National Heart, Lung, and...

Student Perceptions of Autonomy-Supportive Instructional Interactions in the Middle Grades

ERIC Educational Resources Information Center

Wallace, Tanner LeBaron; Sung, Hannah C.

2017-01-01

Autonomy support in classrooms is believed to coordinate students' inner motivational resources in ways that enhance student engagement (e.g., Jang, Kim, & Reeve, 2012). Yet, to our knowledge, no study has investigated student-generated interpretations of the motivational significance of their teachers' autonomy-supportive practices.…

Accent, Perpetual Foreigner Stereotype, and Perceived Discrimination as Indirect Links between English Proficiency and Depressive Symptoms in Chinese American Adolescents

ERIC Educational Resources Information Center

Kim, Su Yeong; Wang, Yijie; Deng, Shiying; Alvarez, Rocio; Li, Jing

2011-01-01

The current study uses Garcia Coll et al.'s (1996) developmental competence model of ethnic minority children and Kim's (1999) racial triangulation theory as frameworks for investigating the mechanisms whereby early adolescent English proficiency relates to perceived discriminatory experiences and adolescent depressive symptoms. Data from 444…

Strengthening Principal Leadership Is Only One Piece of the Puzzle. Lessons from Research

ERIC Educational Resources Information Center

Killion, Joellen

2015-01-01

In this article, Joellen Killion highlights the methodology, analysis, findings, and limitations of Jacob, R., Goddard, R., Kim, M., Miller, R., & Goddard, Y. (2015, September). "Exploring the causal impact of the McREL Balanced Leadership program on leadership, principal efficacy, instructional climate, educator turnover, and student…

Working Papers in Art Education, 1981.

ERIC Educational Resources Information Center

Zurmuehlen, Marilyn, Ed.

1981-01-01

Papers by graduate students, and occasionally papers from their mentors which establish a context for the student papers, are organized into four sections. Section 1, "Observation," includes two papers, "Observation Children at a Puppet Theater Performance" (Grace Johnson), and "Manipulations: Clay Construction" (Kim Spradling). Section 2,…

Homelessness in America.

ERIC Educational Resources Information Center

Baumohl, Jim, Ed.

This book about homelessness in the United States offers 16 chapters in three parts. Part 1, "History Definitions, and Causes," includes: (1) "Redefining the Cursed Word: A Historical Interpretation of American Homelessness" (Kim Hopper and Jim Baumohl); (2) "Homelessness: Definitions and Counts" (Martha R. Burt); (3)…

Proceedings of the Annual Meeting of the Association for Education in Journalism and Mass Communication (82nd, New Orleans, Louisiana, August 3-8, 1999). Communication Technology and Policy.

ERIC Educational Resources Information Center

Association for Education in Journalism and Mass Communication.

The Communication Technology and Policy section of the Proceedings contains the following 15 papers: "The Virtual Sphere: The Internet as a Public Sphere" (Zizi Papacharissi); "Toward a Typology of Internet Users and Online Privacy Concerns" (Kim Bartel Sheehan); "Blind Spots of the Communications Decency Act Debate: A…

The Value Orientations and Sense of Social Well-Being of the Young Family

ERIC Educational Resources Information Center

Tikhomirova, V. V.

2011-01-01

Research in the Komi region of Russia shows that families are experiencing financial problems, but that the desire to have children is strong. The data also show that fathers are more willing to share in family tasks. (Contains 3 tables.) [This article was translated by Kim Braithwaite.

Corruption in the System of Higher Education: Problems and Ways to Prevent Them

ERIC Educational Resources Information Center

Gostev, A. N.; Demchenko, T. S.; Borisova, E. A.

2015-01-01

On the basis of an analysis of the literature, social practice, and the results of a concrete sociological survey, the article examines the main problems of education in Russia today, the ways they are conditioned by corruption, and possible solutions. [This article was translated by Kim Braithwaite.

Comparing Native and Non-Native Raters of US Federal Government Speaking Tests

ERIC Educational Resources Information Center

Brooks, Rachel Lunde

2013-01-01

Previous Language Testing research has largely reported that although many raters' characteristics affect their evaluations of language assessments (Reed & Cohen, 2001), being a native speaker or non-native speaker rater does not significantly affect final ratings (Kim, 2009). In Second Language Acquisition, some researchers conclude that…

Proceedings of the Annual Meeting of the Association for Education in Journalism and Mass Communication (86th, Kansas City, Missouri, July 30-August 2, 2003). Advertising Division.

ERIC Educational Resources Information Center

2003

The Advertising Division of the proceedings contains the following 20 papers: "Stereotyping the 'Model Minority': A Longitudinal Analysis of U.S. Primetime Network Commercials, Comparing Asian Female and Male Characters to Themselves and Others" (Dennis J. Ganahl, Liang Ge and Kwangok Kim); "Cultivation Effects of Television…

Feminist Struggles to Mobilise Progressive Spaces within the "Boy-Turn" in Gender Equity and Schooling Reform

ERIC Educational Resources Information Center

Keddie, Amanda

2010-01-01

This article presents the stories of two Australian feminist educators, "Kath" and "Kim". Drawn from a small-scale interview-based study, the stories highlight these women's struggles to mobilise progressive spaces within the current boy-focused equity and schooling agenda. Such struggles are located within the new…

"Stick with Yourselves; It's What's Normal": The Intergroup Racial Attitudes of Senior, White, Fraternity Men

ERIC Educational Resources Information Center

Morgan, Demetri L.; Zimmerman, Hilary B.; Terrell, Tanner N.; Marcotte, Beth A.

2015-01-01

Substantive cross-racial interaction on college campuses has been known to have positive effects on student learning and development (Chang, Astin, & Kim, 2004). However, literature shows that students from different minoritized racial groups often remain separated from majority White groups, such as fraternities, thus prohibiting each group…

Adaptation, Acculturation, and Ethnicity.

ERIC Educational Resources Information Center

Fragoso, Jose M.

1991-01-01

Summarizes the essential theoretical features in "Communication and Cross-Cultural Adaptation," by Young Yun Kim. Applies this theory of acculturation as a dynamic communication process to the multigenerational cross-cultural shift of Mexican-Americans described in "Chicano Identity," by Susan E. Keefe and Amado M. Padilla. (SV)

Engaging Spirituality and an Authentic Self in the Intercultural Communication Class

ERIC Educational Resources Information Center

Hamlet, Janice D.

2009-01-01

Intercultural communication focuses on understanding the relationship between culture and communication. The goal of such understanding is to assist students in developing awareness, competency, and sensitivity in communicating with persons who have cultural backgrounds (and perspectives) different from their own, or what Young Yun Kim (2001)…

The Future of the U.S.-ROK Alliance and the Rise of China

DTIC Science & Technology

2009-03-01

Americanism.178 South Korean opposition leaders and human rights activists criticized the Reagan administration’s “quiet diplomacy” on human rights abuse ...hazard” for other rogue nations.207 Believing that the primary motivation of “malignant narcissist ” Kim Jong-il for the development of nuclear

Proceedings of the Annual Meeting of the Association for Education in Journalism and Mass Communication (82nd, New Orleans, Louisiana, August 3-8, 1999). Mass Communication and Society.

ERIC Educational Resources Information Center

Association for Education in Journalism and Mass Communication.

The Mass Communication and Society section of the Proceedings contains the following 17 papers: "Interactivity and the 'Cyber-Fan': Audience Involvement within the Electronic Fan Culture of the Internet" (Vic Costello); "A Reassessment of the Relationship between Public Affairs Media Use and Political Orientations" (Kim A.…

Parents as Catalyst: The Role of Parents in the Development of the Young Child in Asia. Child Survival and Development Workshop Report (Singapore, February 1-7, 1993).

ERIC Educational Resources Information Center

Regional Training and Resource Centre in Early Childhood Care and Education for Asia (Singapore).

In February 1993, a regional workshop on alternative ways of working with parents, brought together 50 senior officers from both government and nongovernmental organizations from 16 Asian countries. Following the welcoming remarks of Khoo Kim Choo, this report presents the following addresses, presentations, and discussions: (1) "Parent…

Understanding of Materials State and its Degradation using Non-Linear Ultrasound Approaches for Lamb Wave Propagation

DTIC Science & Technology

2015-05-31

Institution : Indian Institute of Technology Madras - Mailing Address : MDS 301, Department of Mechanical Engineering, IIT Campus, Chennia INDIA 600036...in ceramic composites using an ultrasonic guided wave scan system”, 30th Annual Rev. of Quan. NDE, 2003; NASA /TM-2003-212518. [15] J Y Kim, J Qu

A 20-Year Comparison of Teachers' Agricultural Mechanics Laboratory Management Competency

ERIC Educational Resources Information Center

McKim, Billy R.; Saucier, P. Ryan

2013-01-01

Agricultural mechanics laboratory management skills are essential for school-based agriculture teachers who instruct students in an agricultural mechanics laboratory (Bear & Hoerner, 1986). McKim and Saucier (2011) suggested the frequency and severity of accidents that occur in these laboratories can be reduced when these facilities are…

Core Reflection as Self-Fulfilling Prophecy: Implications for Teacher Education

ERIC Educational Resources Information Center

Zimmerman, Aaron Samuel

2017-01-01

In this commentary, I explore a method of teacher reflection developed by Korthagen and colleagues, which they refer to as "core reflection" (Korthagen, Kim, & Green, 2013). Specifically, I have noticed that the process of "core reflection" bears a strong resemblance to self-fulfilling prophecies and other "placebo…

Game-Based Assessments: A Promising Way to Create Idiographic Perspectives

ERIC Educational Resources Information Center

Walker, A. Adrienne; Engelhard, George, Jr.

2014-01-01

"Game-Based Assessments: A Promising Way to Create Idiographic Perspectives" (Adrienne Walker and George Englehard) comments on: "How Task Features Impact Evidence from Assessments Embedded in Simulations and Games" by Russell G. Almond, Yoon Jeon Kim, Gertrudes Velasquez, and Valerie J. Shute. Here, Walker and Englehard write…

KSC-08pd1773

NASA Image and Video Library

2008-06-17

CAPE CANAVERAL, Fla. – On Launch Pad 39A at NASA's Kennedy Space Center, Daytona International Speedway President Robin Braig (left) and 2008 Daytona 500 winner Ryan Newman pose for photographers with the Daytona International Speedway show car. Newman is visiting Kennedy in honor of NASA's 50th anniversary and the 50th running of NASCAR's Daytona 500 in February. NASA presented Newman two green racing flags that were flown last February aboard space shuttle Atlantis' STS-122 mission to the International Space Station. One flag was given to Newman, the second was presented to Daytona 500 Experience General Manager Kim Isemann. A third flag that was flown will be kept by NASA for public display. The connection between NASA and Daytona's International Speedway extends beyond their close proximity to one another. During recent years, technology developed for the space program has found many uses on Earth, including helping NASCAR drivers stay safe and increase performance. Photo credit: NASA/Kim Shiflett

Anthropogenic enhancement of moderate-to-strong El Niño events likely contributed to drought and poor harvests in southern Africa during 2016

USGS Publications Warehouse

Funk, Chris; Davenport, Frank; Harrison, Laura; Magadzire, Tamuka; Galu, Gideon; Artan, Guleid A.; Shukla, Shraddhanand; Korecha, Diriba; Indeje, Matayo; Pomposi, Catherine; Macharia, Denis; Husak, Gregory; Dieudonne Nsadisa, Faka

2018-01-01

In December–February (DJF) of 2015/16, a strong El Niño (Niño‑3.4 SST >29°C) contributed to a severe drought over southern Africa (SA; Funk et al. 2016). A 9-million ton cereal deficit resulted in 26 mil‑ lion people in need of humanitarian assistance (SADC 2016). While SA rainfall has a well-documented nega‑ tive teleconnection with Niño‑3.4 SSTs (Hoell et al. 2015, 2017; Jury et al. 1994; Lindesay 1988; Misra 2003; Nicholson and Entekhabi 1987; Nicholson and Kim 1997; Reason et al. 2000; Rocha and Simmonds 1997), the link between climate change and El Niño remains unclear (Christensen et al. 2013) due to the large natural variability of ENSO SSTs (Wittenberg 2009), uncertainties surrounding measurements and trends (Solomon and Newman 2012), intermodel differences in ENSO representation and feedbacks (Guilyardi et al. 2012; Kim et al. 2014), and difficulties associated with quantifying ENSO strength (Cai et al. 2015).

Second Language Writing Development: A Research Agenda

ERIC Educational Resources Information Center

Polio, Charlene

2017-01-01

In 1998, Wolfe-Quintero, Inagaki & Kim published a monograph describing measures used in assessing writing development. Despite more recent research on linguistic development (e.g., Bulté & Housen 2012; Verspoor, Schmid & Xu 2012; Connor-Linton & Polio 2014), the volume is still a valuable resource and good starting point for…

Physical Activity Intensity, Lesson Context, and Teacher Interactions during an Unstructured Afterschool Physical Activity Program

ERIC Educational Resources Information Center

Behrens, Timothy K.; Miller, Daniel J.; Schuna, John M.; Liebert, Mina L.

2015-01-01

Background: Afterschool programs are promising arenas to improve youth physical activity (PA) levels. During the school year for 2012-2013, 5 elementary schools from a low-socioeconomic status (SES) school district in southern Colorado participated in evaluation of the afterschool program entitled Keep It Moving! (KIM). Methods: In this…

A Matched Field Processing Framework for Coherent Detection Over Local and Regional Networks (Postprint)

DTIC Science & Technology

2011-12-30

the term " superresolution "). The single-phase matched field statistic for a given template was also demonstrated to be a viable detection statistic... Superresolution with seismic arrays using empirical matched field processing, Geophys. J. Int. 182: 1455–1477. Kim, K.-H. and Park, Y. (2010): The 20

78 FR 76598 - Membership of the Performance Review Board

Federal Register 2010, 2011, 2012, 2013, 2014

2013-12-18

..., LARRY G. KIM, ROBERT KOEPPEL, DENNIS LABRECK, JANET L. LAKIN, KENNETH CHARLES LHAMON, CATHERINE E. LIM..., SEAN P. CANELLOS, ERNEST C. CARR, PEGGY G. CARTER, DENISE L. CHAVEZ, ANTHONY S. CHISM, MONIQUE M..., LIBIA S. GOMEZ, GABRIELLA GONIPROW, ALEXANDER GRAHAM, DARRELL W. GREWAL, SATYAMDEEP S. HALL, LINDA W...

78 FR 48435 - Ocean Transportation Intermediary License Applicants

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-08

... & OFF), 370 S. Crenshaw Blvd., Suite E202A, Torrance, CA 90503, Officers: Charles W. Dobeck, Member (QI...), Hoboken Business Center, 50 Harrison Street, Suite 301, Hoboken, NJ 07030, Officers: Jose L. Ramirez..., President (QI), Sean W. Kim, Director, Application Type: New NVO & OFF License. In Motion Logistics, LLC...

Analysis of Generation Y Workforce Motivation Using Multiattribute Utility Theory

DTIC Science & Technology

2011-01-01

careers and professional development (Westerman and Yamamura, 2007; Kim et al., 2009; Zemke et al., 2000). Generation Y aspires for a work / life balance (Crumpacker...within the federal govern- ment. The majority of Generation Y research is done on the work / life balance factor. Research points to this new

Genetics Home Reference: ACAD9 deficiency

MedlinePlus

... Oct 24. Citation on PubMed Schiff M, Haberberger B, Xia C, Mohsen AW, Goetzman ES, Wang Y, Uppala R, Zhang Y, Karunanidhi A, Prabhu D, Alharbi H, Prochownik EV, Haack T, Häberle J, Munnich A, Rötig A, Taylor RW, Nicholls RD, Kim JJ, Prokisch H, Vockley ...

Specialty Choices of Kuwaiti Medical Graduates during the Last Three Decades

ERIC Educational Resources Information Center

Al-Jarallah, Khaled F.; Moussa, Mohamed A. A.

2003-01-01

Introduction: This study examined postgraduate specialty training of Kuwaiti medical graduates during 1968 to 1999 and identified their attained professional qualifications to reveal scarcity in some specialties. Method: A survey was carried out involving review of the records maintained at the Kuwait Institute for Medical Specialization (KIMS)…

The Problem of Mobbing in a College Department

ERIC Educational Resources Information Center

Druzhilov, S. A.

2012-01-01

The phenomenon of harassment in Russian universities creates an environment that can be both threatening to the individual and a source of poor performance by the work group. Policies need to be developed to deal with this destructive form of behavior. [This article was translated by Kim Braithwaite.

76 FR 37788 - Fisheries of the South Atlantic; South Atlantic Fishery Management Council; Public Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-28

... meeting of its Law Enforcement AP in Orlando, FL. DATES: The meeting will take place July 20, 2011. See SUPPLEMENTARY INFORMATION. ADDRESSES: The meeting will be held at the Marriott Renaissance Orlando Hotel, 5445 Forbes Place, Orlando, FL 32812; telephone: (407) 240-1000. FOR FURTHER INFORMATION CONTACT: Kim Iverson...

First description of the male of Draconarius jiangyongensis (Peng et al., 1996) (Araneae, Agelenidae)

PubMed Central

Chen, Zhuoer; Yin, Haiqiang; Xu, Xiang

2016-01-01

Abstract The male of Draconarius jiangyongensis (Peng, Gong & Kim, 1996) is described for the first time from Xinning County, Hunan Province, China. Morphological descriptions and illustrations of both sexes of this species are given in this study. The placement of this species in Draconarius is doubted. PMID:27551186

Translations on North Korea, Number 573.

DTIC Science & Technology

1978-02-02

Production 61 Ore Production 61 Changsong Mine 61 - c - KIM IL-SONG PHOTOS APPEARING IN ’NODONG SINMUN,’ DECEMBER 1977 [Editorial Report] The...Pyongyang Domestic Service in Korean 0800 GMT 12 Jan 78 SK] CHANGSONG MINE—The Changsong mine has overfulfilled the tagets set for tunneling by 270

A Perfectly Matched Layer for Peridynamics in Two Dimensions

DTIC Science & Technology

2013-04-01

KIM Seoul National University, Republic of Korea Z. MROZ Academy of Science, Poland D. PAMPLONA Universidade Católica do Rio de Janeiro , Brazil M. B...applications, Prentice-Hall, Upper Saddle River , NJ, 1996. [Silling 2000] S. A. Silling, “Reformulation of elasticity theory for discontinuities and long

Learner Perceptions of Online Peer Pronunciation Feedback through P-Check

ERIC Educational Resources Information Center

Yonesaka, Suzanne M.

2017-01-01

Receiving adequate pronunciation feedback is an ongoing challenge for L2 learners. Although instructors are the most important source of corrective pronunciation feedback (Szpyra, 2014; Timson, 2007), L2 learners can also benefit from peer pronunciation feedback (Lord, 2008; Kim & Yoon, 2014; Roccamo, 2015). This paper examines Japanese…

A North Korean Social Revolution in the Democratic People’s Republic of Korea

DTIC Science & Technology

2014-12-04

govern northern Korea. The DPRK regime began with Kim Il Sung and his North Korean Communist Party in the late Michigan: Pluto Press, 2008), 48, 79...Kwon. North Korea on the Brink: Struggle for Survival. Ann Arbor and London: Pluto Press, 2008. Fuqua Jr., Jacques L. Korean Unification: Inevitable

MAOA-uVNTR and Early Physical Discipline Interact to Influence Delinquent Behavior

ERIC Educational Resources Information Center

Edwards, Alexis C.; Dodge, Kenneth A.; Latendresse, Shawn J.; Lansford, Jennifer E.; Bates, John E.; Pettit, Gregory S.; Budde, John P.; Goate, Alison M.; Dick, Danielle M.

2010-01-01

Background: A functional polymorphism in the promoter region of the monoamine oxidizing gene "monoamine oxidase A" ("MAOA") has been associated with behavioral sensitivity to adverse environmental conditions in multiple studies (e.g., Caspi et al. 2002; Kim-Cohen et al., 2006). The present study investigates the effects of…

KSC-2012-5024

NASA Image and Video Library

2012-09-12

CAPE CANAVERAL, Fla. - Jeff Moultrie, pilot of the Shuttle Carrier Aircraft, or SCA, speaks with news media at the Shuttle Landing Facility at NASA's Kennedy Space Center in Florida. The SCA will take space shuttle Endeavour from Florida to Los Angeles for public display. Photo credit: NASA/Kim Shiflett

Rainbows and Rocket Engine

NASA Image and Video Library

2017-02-22

Rainbows and rocket engines – doesn’t get much better than that! Check out these gorgeous aerial views from today’s Space Launch System RS-25 engine test @NASA’s Stennis Space Center. PAO Name:Kim Henry Phone Number:256-544-1899 Email Address: kimberly.m.henry@nasa.gov

KSC-2011-1442

NASA Image and Video Library

2011-02-14

CAPE CANAVERAL, Fla. -- At NASA's Kennedy Space Center in Florida, Center Director Bob Cabana and Public Affairs Director Lisa Malone speak to the local media about the FY 2012 budget during an informal briefing held in the TV studio at the Press Site. Photo credit: NASA/Kim Shiflett

KSC-2011-1439

NASA Image and Video Library

2011-02-14

CAPE CANAVERAL, Fla. -- At NASA's Kennedy Space Center in Florida, Center Director Bob Cabana and Public Affairs Director Lisa Malone speak to the local media about the FY 2012 budget during an informal briefing held in the TV studio at the Press Site. Photo credit: NASA/Kim Shiflett

Core Self-Evaluations as Personal Factors in the World Health Organization's International Classification of Functioning, Disability and Health Model: An Application in Persons with Spinal Cord Injury

ERIC Educational Resources Information Center

Yaghmanian, Rana; Smedema, Susan Miller; Thompson, Kerry

2017-01-01

Purpose: To evaluate Chan, Gelman, Ditchman, Kim, and Chiu's (2009) revised World Health Organization's International Classification of Functioning, Disability and Health (ICF) model using core self-evaluations (CSE) to account for Personal Factors in persons with spinal cord injury (SCI). Method: One hundred eighty-seven adults with SCI were…

2012 Earth Day

NASA Image and Video Library

2012-04-24

Bonnie Humphrey of NASA (l to r), Van Ward of NASA, Kim Maddox of the Naval Oceanographic Office, and Al Bryden of the NASA Shared Services Center learn about the Crosby Arboretum in Picayune, Miss., during the Earth Day celebration at Stennis Space Center on April 24, 2012.

Poloxamer-188 Reduces Muscular Edema After Tourniquet-Induced Ischemia-Reperfusion Injury in Rats

DTIC Science & Technology

2011-05-01

syndrome: fulminant local edema with threatening systemic effects. Kidney Int. 2003;63:1155–1157. 4. Hargens AR, Mubarak SJ. Current concepts in the...Kim DD, et al. Microvascular transport is associated with TNF plasma levels and protein synthesis in postischemic muscle. Am J Physiol. 1998;274:H1914

KSC-2012-4843

NASA Image and Video Library

2012-09-05

CAPE CANAVERAL, Fla. – A steel beam after being fitted to the highest point of a new exhibit facility under construction at the Kennedy Space Center Visitor Complex. The 90,000-square-foot facility will house space shuttle Atlantis and 62 shuttle program exhibits. Photo credit: NASA/Kim Shiflett

KSC-2012-4840

NASA Image and Video Library

2012-09-05

CAPE CANAVERAL, Fla. – A steel beam is lifted to the highest point of a new exhibit facility under construction at the Kennedy Space Center Visitor Complex. The 90,000-square-foot facility will house space shuttle Atlantis and 62 shuttle program exhibits. Photo credit: NASA/Kim Shiflett

KSC-2012-4841

NASA Image and Video Library

2012-09-05

CAPE CANAVERAL, Fla. – A steel beam is lifted to the highest point of a new exhibit facility under construction at the Kennedy Space Center Visitor Complex. The 90,000-square-foot facility will house space shuttle Atlantis and 62 shuttle program exhibits. Photo credit: NASA/Kim Shiflett

KSC-2012-4842

NASA Image and Video Library

2012-09-05

CAPE CANAVERAL, Fla. – A steel beam after being fitted to the highest point of a new exhibit facility under construction at the Kennedy Space Center Visitor Complex. The 90,000-square-foot facility will house space shuttle Atlantis and 62 shuttle program exhibits. Photo credit: NASA/Kim Shiflett

KSC-2012-4844

NASA Image and Video Library

2012-09-05

CAPE CANAVERAL, Fla. – A steel beam after being fitted to the highest point of a new exhibit facility under construction at the Kennedy Space Center Visitor Complex. The 90,000-square-foot facility will house space shuttle Atlantis and 62 shuttle program exhibits. Photo credit: NASA/Kim Shiflett

The Process of Designing Task Features

ERIC Educational Resources Information Center

Bauer, Malcolm

2014-01-01

Malcolm Bauer, from Education Testing Services, provides his comments on the Focus article in this issue of "Measurement" entitled : "How Task Features Impact Evidence from Assessments Embedded in Simulations and Games" (Russell G. Almond, Yoon Jeon Kim, Gertrudes Velasquez, Valerie J. Shute). Bauer begins his remarks by noting…

Lesson Plans on African History and Geography: A Teaching Resource.

ERIC Educational Resources Information Center

Hamilton, Robert E., Ed.

This document presents lesson plans for instruction concerning the history and geography of the continent of Africa. Topics include: (1) "The Challenge of Teaching African History and Culture" (Robert Hamilton); (2) "A Physical Overview of Africa" (Robert Hamilton and Kim Lilly); (3) "A Cultural Overview of Africa"…

Attack pattern of Platypus koryoensis (Coleoptera: Curculionidae: Platypodidae) in relation to crown dieback of Mongolian oak in Korea

Treesearch

Jung-Su Lee; Robert A. Haack; Won Il. Choi

2011-01-01

The ambrosia beetle, Platypus koryoensis (Murayama), vectors the Korean oak wilt (KOW) pathogen, Raffaelea quercus-mongolicae K.H. Kim, Y.J. Choi, & H.D. Shin, in Korea, which is highly lethal to Mongolian oak, Quercus mongolica Fisch., and is considered a major threat to forest ecosystem health. We...

Subclinical chronic kidney disease modifies the diagnosis of experimental acute kidney injury.

PubMed

Succar, Lena; Pianta, Timothy J; Davidson, Trent; Pickering, John W; Endre, Zoltán H

2017-09-01

Extensive structural damage within the kidney must be present before serum creatinine increases. However, a subclinical phase of chronic kidney disease (CKD) usually goes undetected. Here we tested whether experimental subclinical CKD would modify functional and damage biomarker profiles of acute kidney injury (AKI). Subclinical CKD was induced in rats by adenine or aristolochic acid models but without increasing serum creatinine. After prolonged recovery (three to six weeks), AKI was induced with a subnephrotoxic dose of cisplatin. Urinary levels of kidney injury molecule-1 (KIM-1), cytochrome C, monocyte chemotactic protein-1 (MCP-1), clusterin, and interleukin-18 increased during CKD induction, without an increase in serum creatinine. After AKI in adenine-induced CKD, serum creatinine increased more rapidly, while increased urinary KIM-1, clusterin, and MCP-1 were delayed and reduced. Increased serum creatinine and biomarker excretion were associated with diffuse tubulointerstitial injury in the outer stripe of outer medulla coupled with over 50% cortical damage. Following AKI in aristolochic acid-induced CKD, increased serum creatinine, urinary KIM-1, clusterin, MCP-1, cytochrome C, and interleukin-18 concentrations and excretion were greater at day 21 than day 42 and inversely correlated with cortical injury. Subclinical CKD modified functional and damage biomarker profiles in diametrically opposite ways. Functional biomarker profiles were more sensitive, while damage biomarker diagnostic thresholds and increases were diminished and delayed. Damage biomarker concentrations and excretion were inversely linked to the extent of prior cortical damage. Thus, thresholds for AKI biomarkers may need to be lower or sampling delayed in the known presence of CKD. Crown Copyright © 2017. Published by Elsevier Inc. All rights reserved.

Urinary cystatin C as a renal biomarker and its immunohistochemical localization in anti-GBM glomerulonephritis rats.

PubMed

Togashi, Yuko; Imura, Naoko; Miyamoto, Yohei

2013-11-01

The usefulness of urinary cystatin C for the early detection of renal damage in anti-glomerular basement membrane (GBM) glomerulonephritis rats was investigated and compared to other biomarkers (β2-microglobulin, calbindin, clusterin, epidermal growth factor (EGF), alpha-glutathione S-transferase (GST-α), mu-glutathione S-transferase (GST-μ), kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), osteopontin, tissue inhibitor of metalloprotease-1 (TIMP-1), and vascular endothelial growth factor (VEGF)). Urinary levels of cystatin C increased in anti-GBM glomerulonephritis rats, whereas the conventional markers, plasma creatinine and UN did not, demonstrating its usefulness for the early detection of renal damage associated with anti-GBM glomerulonephritis. As well as cystatin C, urinary β2-microglobulin, clusterin, GST-α, GST-μ, KIM-1, and NGAL also had the potential to detect renal damage associated with anti-GBM glomerulonephritis. Furthermore, the immunohistochemical localization of cystatin C in the kidney was examined. Cystatin C expression was mainly observed in the proximal renal tubules in anti-GBM glomerulonephritis rats, and its expression barely changed with the progression of glomerulonephritis. Cystatin C expression was also observed in the tubular lumen of the cortex and medulla when glomerulonephritis was marked, which was considered to be characteristic of renal damage. In conclusion, urinary cystatin C, β2-microglobulin, clusterin, GST-α, GST-μ, KIM-1, and NGAL could be useful biomarkers of renal damage in anti-GBM glomerulonephritis rats. Immunohistochemical cystatin C expression in the proximal renal tubules was barely changed by the progression of glomerulonephritis, but it was newly observed in the tubular lumen when renal damage was apparent. Crown Copyright © 2013. Published by Elsevier GmbH. All rights reserved.

Smoking Induces Oropharyngeal Narrowing and Increases the Severity of Obstructive Sleep Apnea Syndrome

PubMed Central

Kim, Kyung Soo; Kim, Jun Hee; Park, Sung Yoon; Won, Ho-Ryun; Lee, Hyun-Jin; Yang, Hoon Shik; Kim, Hyun Jik

2012-01-01

Objective: Smoking is a known risk factor for snoring, and is reported to be associated with an increased prevalence of obstructive sleep apnea syndrome (OSAS). The purpose of this was to determine the relationship of smoking to the severity of OSAS and examine what local histological changes in the uvular mucosa of OSAS patients might influence this relationship. Study Design and Methods: Fifty-seven OSAS subjects were included and classified according to smoking history and OSAS severity. Twenty-eight subjects were heavy smokers and 29 were nonsmokers; these 57 patients were divided according to moderate or severe OSAS. Histologic changes in the uvular mucosa were evaluated in all subjects as well as smoking duration and OSAS severity. Results: Among smokers, moderate-to-severe OSAS was more common, and apnea, hypopnea, and oxygen desaturation indices were higher. Moreover, smoking duration and OSAS severity were significantly correlated. Increased thickness and edema of the uvular mucosa lamina propria were observed in moderate and severe OSAS patients, and only smokers had significant changes in uvular mucosa histology. Positive staining for calcitonin gene-related peptide (CGRP), a neuroinflammatory marker for peripheral nerves, was increased in the uvular mucosa of smokers. Conclusions: Our results suggest that smoking may worsen OSAS through exacerbation of upper airway collapse at the level of the uvula, and that histological changes of the uvular mucosa correlated with smoking might be due to increased CGRP-related neurogenic inflammation. Citation: Kim KS; Kim JH; Park SY; Won HR; Lee HJ; Yang HS; Kim HJ. Smoking induces oropharyngeal narrowing and increases the severity of obstructive sleep apnea syndrome. J Clin Sleep Med 2012;8(4):367-374. PMID:22893766

Molecular mechanism of ERK dephosphorylation by striatal-enriched protein tyrosine phosphatase (STEP)

PubMed Central

Li, Hui; Li, Kang-shuai; Su, Jing; Chen, Lai-Zhong; Xu, Yun-Fei; Wang, Hong-Mei; Gong, Zheng; Cui, Guo-Ying; Yu, Xiao; Wang, Kai; Yao, Wei; Xin, Tao; Li, Min-Yong; Xiao, Kun-Hong; An, Xiao-fei; Huo, Yuqing; Xu, Zhi-gang; Sun, Jin-Peng; Pang, Qi

2013-01-01

Striatal-enriched tyrosine phosphatase (STEP) is an important regulator of neuronal synaptic plasticity, and its abnormal level or activity contributes to cognitive disorders. One crucial downstream effector and direct substrate of STEP is extracellular signal-regulated protein kinase (ERK), which has important functions in spine stabilisation and action potential transmission. The inhibition of STEP activity toward phospho-ERK has the potential to treat neuronal diseases, but the detailed mechanism underlying the dephosphorylation of phospho-ERK by STEP is not known. Therefore, we examined STEP activity toward pNPP, phospho-tyrosine-containing peptides, and the full-length phospho-ERK protein using STEP mutants with different structural features. STEP was found to be a highly efficient ERK tyrosine phosphatase that required both its N-terminal regulatory region and key residues in its active site. Specifically, both KIM and KIS of STEP were required for ERK interaction. In addition to the N-terminal KIS region, S245, hydrophobic residues L249/L251, and basic residues R242/R243 located in the KIM region were important in controlling STEP activity toward phospho-ERK. Further kinetic experiments revealed subtle structural differences between STEP and HePTP that affected the interactions of their KIMs with ERK. Moreover, STEP recognised specific positions of a phospho-ERK peptide sequence through its active site, and the contact of STEP F311 with phospho-ERK V205 and T207 were crucial interactions. Taken together, our results not only provide the information for interactions between ERK and STEP, but will also help in the development of specific strategies to target STEP-ERK recognition, which could serve as a potential therapy for neurological disorders. PMID:24117863

Diabetes increases the susceptibility to acute kidney injury after myocardial infarction through augmented activation of renal Toll-like receptors in rats.

PubMed

Ohno, Kouhei; Kuno, Atsushi; Murase, Hiromichi; Muratsubaki, Shingo; Miki, Takayuki; Tanno, Masaya; Yano, Toshiyuki; Ishikawa, Satoko; Yamashita, Tomohisa; Miura, Tetsuji

2017-12-01

Acute kidney injury (AKI) after acute myocardial infarction (MI) worsens the prognosis of MI patients. Although type 2 diabetes mellitus (DM) is a major risk factor of AKI after MI, the underlying mechanism remains unclear. Here, we examined the roles of renal Toll-like receptors (TLRs) in the impact of DM on AKI after MI. MI was induced by coronary artery ligation in Otsuka-Long-Evans-Tokushima fatty (OLETF) rats, a rat DM model, and Long-Evans-Tokushima-Otsuka (LETO) rats, nondiabetic controls. Sham-operated rats served as no-MI controls. Renal mRNA levels of TLR2 and myeloid differentiation factor 88 (MyD88) were significantly higher in sham-operated OLETF rats than in sham-operated LETO rats, although levels of TLR1, TLR3, and TLR4 were similar. At 12 h after MI, protein levels of kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) in the kidney were elevated by 5.3- and 4.0-fold, respectively, and their mRNA levels were increased in OLETF but not LETO rats. The increased KIM-1 and NGAL expression levels after MI in the OLETF kidney were associated with upregulated expression of TLR1, TLR2, TLR4, MyD88, IL-6, TNF-α, chemokine (C-C motif) ligand 2, and transforming growth factor-β 1 and also with activation of p38 MAPK, JNK, and NF-κB. Cu-CPT22, a TLR1/TLR2 antagonist, administered before MI significantly suppressed MI-induced upregulation of KIM-1, TLR2, TLR4, MyD88, and chemokine (C-C motif) ligand 2 levels and activation of NF-κB, whereas NGAL levels and IL-6 and TNF-α expression levels were unchanged. The results suggest that DM increases the susceptibility to AKI after acute MI by augmented activation of renal TLRs and that TLR1/TLR2-mediated signaling mediates KIM-1 upregulation after MI. NEW & NOTEWORTHY This is the first report to demonstrate the involvement of Toll-like recpetors (TLRs) in diabetes-induced susceptibility to acute kidney injury after acute myocardial infarction. We propose that the TLR1/TLR2

N-acteyl-ß-D-glucosaminidase and kidney injury molecule-1: New predictors for long-term progression of chronic kidney disease in patients with heart failure.

PubMed

Jungbauer, Carsten G; Uecer, Ekrem; Stadler, Stefan; Birner, Christoph; Buchner, Stefan; Maier, Lars S; Luchner, Andreas

2016-06-01

Patients with chronic heart failure (CHF) are often characterized by the cardiorenal syndrome (CRS). The aim of the present study was to assess whether novel markers of kidney injury are able to predict progression of chronic kidney disease (CKD) in patients with CHF. New renal biomarkers, N-acteyl-ß-D-glucosaminidase (NAG), kidney injury molecule-1 (KIM-1) and Neutrophil Gelatinase-Associated Lipocalin (NGAL), were assessed from urine samples of 149 patients with chronic heart failure. During a 5-year-follow-up, renal function was assessed by creatinine and estimated glomerular filtration rate (eGFR CKD EPI) and was available for 138 patients. Further, data regarding all-cause mortality was obtained. Twenty-six patients (18.8%) developed a progression of CKD during the follow-up period, as defined by decline in eGFR category accompanied by a ≥25% drop in eGFR form baseline. No difference regarding age, sex, body mass index, hypertension, diabetes or EF was present between patients with and without CKD progression (each P = n.s.). At baseline, creatinine concentrations and eGFR were significantly different between both groups (sCr: 1.50 ± 0.67 vs 1.04 ± 0.37, P = < 0.001; eGFR: 47.8 ± 12.3 vs. 77.3 ± 23.5 mL/min per 1.73m(2) , each P < 0.001). In a Kaplan-Meier-analysis, KIM-1 and NAG were significant predictors for CKD progression (both P < 0.05). In Cox regression analysis, NAG > median (OR 3.25,P = 0.013), initial eGFR (OR 0.94, P < 0.001) and diuretic use (OR 3.92, P = 0.001) were independent predictors of CKD progression. Further, KIM-1 and NAG were also independent predictors of a combined endpoint of CKD progression and all-cause mortality by Cox regression analysis (each P < 0.05). The combination of both markers showed additive value regarding both endpoints. NGAL showed no association with CKD progression. During long-term follow-up chronic heart failure patients with CKD show a relevant disease progression. The

YopJ-Induced Caspase-1 Activation in Yersinia-Infected Macrophages: Independent of Apoptosis, Linked to Necrosis, Dispensable for Innate Host Defense

PubMed Central

Zheng, Ying; Lilo, Sarit; Mena, Patricio; Bliska, James B.

2012-01-01

Yersinia outer protein J (YopJ) is a type III secretion system (T3SS) effector of pathogenic Yersinia (Yersinia pestis, Yersinia enterocolitica and Yersinia pseudotuberculosis) that is secreted into host cells. YopJ inhibits survival response pathways in macrophages, causing cell death. Allelic variation of YopJ is responsible for differential cytotoxicity in Yersinia strains. YopJ isoforms in Y. enterocolitica O:8 (YopP) and Y. pestis KIM (YopJKIM) strains have high cytotoxic activity. In addition, YopJKIM-induced macrophage death is associated with caspase-1 activation and interleukin-1β (IL-1β secretion. Here, the mechanism of YopJKIM-induced cell death, caspase-1 activation, and IL-1β secretion in primary murine macrophages was examined. Caspase-3/7 activity was low and the caspase-3 substrate poly (ADP-ribose) polymerase (PARP) was not cleaved in Y. pestis KIM5-infected macrophages. In addition, cytotoxicity and IL-1β secretion were not reduced in the presence of a caspase-8 inhibitor, or in B-cell lymphoma 2 (Bcl-2)-associated X protein (Bax)/Bcl-2 homologous antagonist/killer (Bak) knockout macrophages, showing that YopJKIM-mediated cell death and caspase-1 activation occur independent of mitochondrial-directed apoptosis. KIM5-infected macrophages released high mobility group protein B1 (HMGB1), a marker of necrosis, and microscopic analysis revealed that necrotic cells contained active caspase-1, indicating that caspase-1 activation is associated with necrosis. Inhibitor studies showed that receptor interacting protein 1 (RIP1) kinase and reactive oxygen species (ROS) were not required for cytotoxicity or IL-β release in KIM5-infected macrophages. IL-1β secretion was reduced in the presence of cathepsin B inhibitors, suggesting that activation of caspase-1 requires cathepsin B activity. Ectopically-expressed YopP caused higher cytotoxicity and secretion of IL-1β in Y. pseudotuberculosis-infected macrophages than YopJKIM. Wild-type and congenic

Visualizing Sound Directivity via Smartphone Sensors

ERIC Educational Resources Information Center

Hawley, Scott H.; McClain, Robert E., Jr.

2018-01-01

When Yang-Hann Kim received the Rossing Prize in Acoustics Education at the 2015 meeting of the Acoustical Society of America, he stressed the importance of offering visual depictions of sound fields when teaching acoustics. Often visualization methods require specialized equipment such as microphone arrays or scanning apparatus. We present a…

Productivity in Educational Psychology Journals from 2003 to 2008

ERIC Educational Resources Information Center

Jones, Sara J.; Fong, Carlton J.; Torres, Laura G.; Yoo, Julia H.; Decker, Mark Lowry; Robinson, Daniel H.

2010-01-01

Productivity of individuals and institutions in educational psychology journals has been previously examined in three separate studies (Hsieh et al. [Hsieh, P., Acee, T., Chung, W., Hsieh, Y., Kim, H., Thomas, G. D., et al. (2004). An alternate look at educational psychologist's productivity from 1991 to 2002. "Contemporary Educational Psychology,…

Lawyers' Lines of Work: Specialization's Role in the Income Determination Process

ERIC Educational Resources Information Center

Leahey, Erin; Hunter, Laura A.

2012-01-01

Income inequality has been increasing in the United States, and "intraoccupational" processes are partly responsible (Kim and Sakamoto 2008; Mouw and Kalleberg 2010). To date, scholars have focused on suboccupational divisions, such as specialty areas, to understand why some members of an occupation earn more than others. In this article we…

Developing 21st Century Chemistry Learning through Designing Digital Games

ERIC Educational Resources Information Center

Lay, Ah-Nam; Osman, Kamisah

2018-01-01

The purpose of this study is to investigate the effect of Malaysian "Kimia" (Chemistry) Digital Games (MyKimDG) module on students' achievement and motivation in chemistry as well as 21st century skills. Chemistry education in Malaysia should put greater emphasis on combination of cognitive, sociocultural and motivational aspects to…

Cancel all Hollidays for SLX4 mutations: identification of a new Fanconi anemia subtype, FANCP.

PubMed

Kang, M H

2011-07-01

SLX4, a coordinator of structure-specific endo-nucleases, is mutated in a new Fanconi anemia subtype Stoepker et al. (2011) Nature Genetics 43:138-141. Mutations of the SLX4 gene in Fanconi anemia Kim et al. (2011) Nature Genetics 43:142-146. © 2011 John Wiley & Sons A/S.

The Influence of Film and Experiential Pedagogy on Multicultural Counseling Self-Efficacy and Multicultural Counseling Competence

ERIC Educational Resources Information Center

Greene, Jennifer H.; Barden, Sejal M.; Richardson, Edrica D.; Hall, Kristopher G.

2014-01-01

Scholarly discourse has emphasized the need for culturally competent practices. Additionally, multicultural self-efficacy has been found to be critical in working with clients from diverse backgrounds, however, there is a relative paucity of literature on how to teach counselor trainees to be culturally competent and self-efficacious (Kim &…

Listening for the Squeaky Wheel: Designing Distance Writing Program Assessment

ERIC Educational Resources Information Center

Tucker, Virginia M.

2012-01-01

Distance writing programs still struggle with assessment strategies that can evaluate student writing as well as their ability to communicate about that writing with peers at a distance. This article uses Kim, Smith and Maeng's 2008 distance education program assessment scheme to evaluate a single distance writing program at Old Dominion…

Proceedings of the Annual Meeting of the Association for Education in Journalism and Mass Communication (79th, Anaheim, CA, August 10-13, 1996). Status of Women and Minorities and Communication Division.

ERIC Educational Resources Information Center

Association for Education in Journalism and Mass Communication.

The Status of Women and Minorities and Communication section of the proceedings contains the following 14 papers: "Who Harasses Women Journalists? A Qualitative Look at Sexual Harassment among U.S. Newswomen" (Kim Walsh-Childers and others); "Not There Yet--Coverage of Women in Foreign News: A 1995 Multi-National Study" (Anat…

Homeostatic and Circadian Abnormalities in Sleep and Arousal in Gulf War Syndrome

DTIC Science & Technology

2016-10-01

prefrontal cortex have been reported in patients with clinical sleep disorders, including insomnia and cataplexy.7-9 A recent hdEEG analysis of...and parietal gray matter in chronic insomnia : a voxel-based morphometric study. Biol Psychiatry 2010;67:182-5. 8. Joo EY, Tae WS, Kim ST, Hong SB

Carbon Fibre Reinforced Aluminum Matrix Composites, A Critical Review (Les Materiaux Composites a Matrice d’Aluminum Renforcee de Fibres de Carbone, Une Critique),

DTIC Science & Technology

1984-06-01

M.K. ibid., pp. 420-442. Alekhin, V.P. * aateva.., S.M. Fedorov, V.B. Chernyshova , T.A. --. 16. Kim, W.H. ibid., pp. 487-505. Koczak, M.J. Lawley, A...International Conference on Composite Chernyshova , T.A. Materials, Japan Society for Composite Materials, Tokyo, Japan, Kobeleva, L.I. October 1982

KSC-2013-4519

NASA Image and Video Library

2013-12-20

An Erickson Sky Crane helicopter returns the SpaceX Dragon test article to Morro Bay, Cailf., following a test to evaluate the spacecraft's parachute deployment system. The test was part of a milestone under its Commercial Crew Integrated Capability agreement with NASA's Commercial Crew Program. Photo credit: NASA/Kim Shiflett

Teacher Educator Identity Emerging from Identity as a Person

ERIC Educational Resources Information Center

Murphy, M. Shaun; Pinnegar, Stefinee

2011-01-01

Experience is fundamental in identity development. In research, concepts and issues around identity are shaped and confronted in moments of reflection. The act of reflection requires a backward attention to engender a present understanding and create future possibilities. Kim and Greene, and Young and Erickson capture this temporal aspect of…

Proceedings of the Second International Workshop on Advances in Electrocorticography

DTIC Science & Technology

2011-10-28

disrupted to achieve seizure freedom, as implied by the ne- cessity to resect both foci in many patients with dual pathology [22]. Although the likelihood...for treatment. Epilepsia 2002;43:219–27. [22] KimDW, Lee SK,NamH, et al. Epilepsywith dual pathology : surgical treatment of cor- tical dysplasia

Comparing Two Forms of Concept Map Critique Activities to Facilitate Knowledge Integration Processes in Evolution Education

ERIC Educational Resources Information Center

Schwendimann, Beat A.; Linn, Marcia C.

2016-01-01

Concept map activities often lack a subsequent revision step that facilitates knowledge integration. This study compares two collaborative critique activities using a Knowledge Integration Map (KIM), a form of concept map. Four classes of high school biology students (n?=?81) using an online inquiry-based learning unit on evolution were assigned…

KSC-2012-5021

NASA Image and Video Library

2012-09-12

CAPE CANAVERAL, Fla. - Henry Taylor, chief flight engineer on the Shuttle Carrier Aircraft, or SCA, speaks with news media at the Shuttle Landing Facility at NASA's Kennedy Space Center in Florida. The SCA will take space shuttle Endeavour from Florida to Los Angeles for public display. Photo credit: NASA/Kim Shiflett

KSC-2012-5022

NASA Image and Video Library

2012-09-12

CAPE CANAVERAL, Fla. - Henry Taylor, chief flight engineer on the Shuttle Carrier Aircraft, or SCA, speaks with news media at the Shuttle Landing Facility at NASA's Kennedy Space Center in Florida. The SCA will take space shuttle Endeavour from Florida to Los Angeles for public display. Photo credit: NASA/Kim Shiflett

One Web Satellites Ground Breaking

NASA Image and Video Library

2017-03-16

Florida Governor Rick Scott speaks during the groundbreaking ceremony at Kennedy's Exploration Park for OneWeb. The company, in partnership with Airbus, is building a 150,000-square-foot factory to manufacture satellites that will connect all areas of the world to the Internet wirelessly. Photo credit: NASA/Kim Shiflett

77 FR 75169 - Silver Nanoparticles (AgNPs); Information and Comment Request

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-19

... control measures (e.g., engineering controls, work practices, PPE) that are being used in workplaces where... and tissues, (2) decrements in lung function and induction of inflammatory responses, and (3... and tissues when administered via gavage to Sprague-Dawley and F344 rats for 28 and 90 days [Kim et al...

Laboratory Safety Needs of Kentucky School-Based Agricultural Mechanics Teachers

ERIC Educational Resources Information Center

Saucier, P. Ryan; Vincent, Stacy K.; Anderson, Ryan G.

2014-01-01

The frequency and severity of accidents that occur in the agricultural mechanics laboratory can be reduced when these facilities are managed by educators who are competent in the area of laboratory safety and facility management (McKim & Saucier, 2011). To ensure teachers are technically competent and prepared to manage an agricultural…

Influence of Multi-Walled Carbon Nanotubes on the Thermal and Mechanical Behavior of Carbon/Epoxy Composites (Preprint)

DTIC Science & Technology

2007-03-01

Stephenson Chemical Company, Inc. Carbon Nanotechnologies , Inc. 3 produced the multi-walled carbon nanotubes used in this study. The tube diameters range...5125-5132. 11. Kim S. , Pechar T. W. and Marand E., Desalination , 192(2006): 330-339 12. Cai H., Yan F. Y., and Xue Q. J., Materials Science and

Segment Fixed Priority Scheduling for Self Suspending Real Time Tasks

DTIC Science & Technology

2016-08-11

Segment-Fixed Priority Scheduling for Self-Suspending Real -Time Tasks Junsung Kim, Department of Electrical and Computer Engineering, Carnegie...4 2.1 Application of a Multi-Segment Self-Suspending Real -Time Task Model ............................. 5 3 Fixed Priority Scheduling...1 Figure 2: A multi-segment self-suspending real -time task model

Education in Asia and the Pacific: Reviews, Reports and Notes. Number 23.

ERIC Educational Resources Information Center

Education in Asia and the Pacific: Reviews, Reports and Notes, 1986

1986-01-01

The first article in this annual compilation ("Review of an International Conference on the University in the Future World," by Ransoo Kim) describes an international conference of Christian universities, held in May, 1985 at Yonsei University, to review the functions, problems, and missions of universities from a global perspective. Universities…

Busting Myths about Nuclear Deterrence

DTIC Science & Technology

2015-01-01

clearly showed Kim Jung Un’s in- tent to develop ballistic missiles capable of delivering a nuclear warhead against an Asian ally and possibly US...consequences of such aggression against the United States. Carl von Clausewitz ob- served in his classic work, On War, that when the potential exists for

Connecting Lines of Research on Task Model Variables, Automatic Item Generation, and Learning Progressions in Game-Based Assessment

ERIC Educational Resources Information Center

Graf, Edith Aurora

2014-01-01

In "How Task Features Impact Evidence from Assessments Embedded in Simulations and Games," Almond, Kim, Velasquez, and Shute have prepared a thought-provoking piece contrasting the roles of task model variables in a traditional assessment of mathematics word problems to their roles in "Newton's Playground," a game designed…

Diversity Management in Preschools Using a Critical Incident Approach

ERIC Educational Resources Information Center

Stier, Jonas; Tryggvason, Marja-Terttu; Sandstrom, Margareta; Sandberg, Anette

2012-01-01

Using the critical incident approach, preschool teachers at 10 preschools in Sweden were asked to describe their work with respect to ethnic and cultural diversity. The study attempted to provide insights that go beyond commonly used models of intercultural sensitivity and intercultural competence (e.g. Gudykunst and Kim; Landis, Bennett, and…

Publication Bias Currently Makes an Accurate Estimate of the Benefits of Enrichment Programs Difficult: A Postmortem of Two Meta-Analyses Using Statistical Power Analysis

ERIC Educational Resources Information Center

Warne, Russell T.

2016-01-01

Recently Kim (2016) published a meta-analysis on the effects of enrichment programs for gifted students. She found that these programs produced substantial effects for academic achievement (g = 0.96) and socioemotional outcomes (g = 0.55). However, given current theory and empirical research these estimates of the benefits of enrichment programs…

A Fair Comparison of the Performance of Computerized Adaptive Testing and Multistage Adaptive Testing

ERIC Educational Resources Information Center

Wang, Keyin

2017-01-01

The comparison of item-level computerized adaptive testing (CAT) and multistage adaptive testing (MST) has been researched extensively (e.g., Kim & Plake, 1993; Luecht et al., 1996; Patsula, 1999; Jodoin, 2003; Hambleton & Xing, 2006; Keng, 2008; Zheng, 2012). Various CAT and MST designs have been investigated and compared under the same…

The Distribution of Russian College Students by Forms of Enrollment

ERIC Educational Resources Information Center

Pugach, V. F.

2014-01-01

During the past two decades, the proportion of students in higher education in Russia who are studying through correspondence, or distance learning, programs has increased to about half of all enrolled students. This trend has occurred in both state and private universities in Russia. [This article was translated by Kim Braithwaite.

Assessing Multicultural Competence: Perceived versus Demonstrated Performance

ERIC Educational Resources Information Center

Cartwright, Brenda Y.; Daniels, Judy; Zhang, Shuqiang

2008-01-01

This study compares self-report scores generated by the Multicultural Awareness Knowledge Skills Survey-Counselor Edition-Revised (B. S. K. Kim, B. Y. Cartwright, P. A. Asay, & M. J. D'Andrea, 2003) with independent observer ratings of actual videotaped demonstrations of multicultural competence in response to a preselected case vignette.…

Autonomy as Process and Outcome: Revisiting Cultural and Practical Issues in Motivation for Counseling

ERIC Educational Resources Information Center

Lynch, Martin F.; Vansteenkiste, Maarten; Deci, Edward L.; Ryan, Richard M.

2011-01-01

Three commentators (Carter, 2011; Kim, 2011; Scheel, 2011) concurred with a central proposition of the target article (Ryan, Lynch, Vansteenkiste, & Deci, 2011): that client motivation for counseling is of critical importance to counselors and therapists. In this Reply, we acknowledge and address a number of issues raised by the commentators,…

Distributed Scaffolding: Synergy in Technology-Enhanced Learning Environments

ERIC Educational Resources Information Center

Ustunel, Hale H.; Tokel, Saniye Tugba

2018-01-01

When technology is employed challenges increase in learning environments. Kim et al. ("Sci Educ" 91(6):1010-1030, 2007) presented a pedagogical framework that provides a valid technology-enhanced learning environment. The purpose of the present design-based study was to investigate the micro context dimension of this framework and to…

The Marginalized "Model" Minority: An Empirical Examination of the Racial Triangulation of Asian Americans

ERIC Educational Resources Information Center

Xu, Jun; Lee, Jennifer C.

2013-01-01

In this article, we propose a shift in race research from a one-dimensional hierarchical approach to a multidimensional system of racial stratification. Building upon Claire Kim's (1999) racial triangulation theory, we examine how the American public rates Asians relative to blacks and whites along two dimensions of racial stratification: racial…

Visual Speech Primes Open-Set Recognition of Spoken Words

ERIC Educational Resources Information Center

Buchwald, Adam B.; Winters, Stephen J.; Pisoni, David B.

2009-01-01

Visual speech perception has become a topic of considerable interest to speech researchers. Previous research has demonstrated that perceivers neurally encode and use speech information from the visual modality, and this information has been found to facilitate spoken word recognition in tasks such as lexical decision (Kim, Davis, & Krins,…

Blue Ocean Thinking

ERIC Educational Resources Information Center

Orem, Donna

2016-01-01

This article describes a concept called the "blue ocean thinking strategy," developed by W. Chan Kim and Renée Mauborgne, professors at INSEAD, an international graduate school of business in France. The "blue ocean" thinking strategy considers opportunities to create new markets for services, rather than focusing solely on…

NEONATAL LOW- AND HIGH-DOSE EXPOSURE TO ESTRADIOL BENZOATE IN THE MALE RAT: I. EFFECTS ON THE PROSTATE GLAND

EPA Science Inventory

Neonatal Low- And High-Dose Exposure To Estradiol Benzoate In The Male Rat: 1. Effects On The Prostate Gland. Oliver Putz, Christian B. Schwartz, Steve Kim, Gerald A. LeBlanc Ralph L. Cooper, Gail S. Prins

ABSTRACT
Brief exposure of rats to high doses of natural estro...

Using Technology to Support Statistical Reasoning: Birds, Eggs and Times to Hatch

ERIC Educational Resources Information Center

Reeve, Elizabeth; Beswick, Kim

2013-01-01

This article by Elizabeth Reeve and Kim Beswick illustrates how primary children may engage with the Statistics and Probability content contained in the Australian Curriculum. Technology has opened up many possibilities for young children to engage with statistics. In the process the children learned a great deal more than just mathematics.

In Praise of Assessment (Done Right)

ERIC Educational Resources Information Center

Marshall, Kim

2018-01-01

High-stakes testing gets a lot of criticism, for good reason. But, when done right, assessment can be a valuable tool for educators and students. Kim Marshall describes how different types of assessments can improve learning by revealing learning problems in real time, improving student retention through the "retrieval effect," and…

The Barracks Subculture of Military School Students

ERIC Educational Resources Information Center

Poliakov, R. Iu.

2011-01-01

The subcultures that develop among military students have a powerful influence on their values and behavior, and in some situations are more influential than the official, military culture. Any attempt to improve levels of discipline in the military cannot afford to ignore these subcultures. [This article was translated by Kim Braithwaite.

Resonant and Nonresonant Nonlinear Optical Spectroscopy of CDSE Quantum Dots for Nonlinear Photonic Applications

DTIC Science & Technology

2006-11-01

Temple D., Yoo K. P., Kim S. Y., Mott A., Namkung M., and Jung S. S., 2003: Large and pure refractive nonlinearity of nanostructure silica ... aerogel , Appl. Phys. Lett., 82(25), 4444-4446. [18] Sun W., Patton T., Stultz L., andClaude J. P., 2003: Resonant third-order nonlinearities of tetrakis

KSC-2012-4834

NASA Image and Video Library

2012-09-05

CAPE CANAVERAL, Fla. – Signatures on a steel beam that was placed at the highest point of a new exhibit facility under construction at the Kennedy Space Center Visitor Complex. The 90,000-square-foot facility will house space shuttle Atlantis and 62 shuttle program exhibits. Photo credit: NASA/Kim Shiflett

Spirituality, Religion, Social Justice Orientation, and the Career Aspirations of Young Adults

ERIC Educational Resources Information Center

Chenot, David; Kim, Hansung

2017-01-01

Spirituality and religion predicted the development of social justice orientation (SJO) among young adults in a previous study (Chenot & Kim, 2013). The current study explores the manner in which the effects of spirituality and religion on social justice orientation vary depending on the career aspirations of young adults. The longitudinal…

Characterization of HgCdTe and Related Materials and Substrates for Third Generation Infrared Detectors

DTIC Science & Technology

2012-12-01

metal-organic vapor phase epitaxy (MOVPE); (iii) convenient n-type and p- type dopants; (iv) versatile methods for forming mesas , planar homojunctions...S. Kim, E. Plis, J. B. Rodriguez , G. D. Bishop, Y. D. Sharma, L. R. Dawson, S. Krishna, J. Bundas, R. Cook, D. Burrows, R. Dennis, K. Patnaude, A

Using Nanotechnology to Detect Nerve Agents

DTIC Science & Technology

2011-01-01

56 | Air & Space Power Journal Air Force Institute of Technology Using Nanotechnology to Detect Nerve Agents Lt Col Mark N. Goltz , PhD, USAF...Retired Dr. Dong Shik Kim Maj LeeAnn Racz, PhD, USAF* *Lieutenant Colonel Goltz and Major Racz are faculty members in the Department of Systems and

New Insights in Catalytic Sites: Characterization of Spectroscopy and Reactivity of Metal Oxide Clusters with Anion Slow Electron Velocity-Map Imaging

DTIC Science & Technology

2016-06-08

Yacovitch, E. Garand, J. B. Kim, C. Hock, T. Theis, and D. M. Neumark, Faraday Disc. 157, 399 (2012). [10] I. Yourshaw, T. Lenzer, G. Reiser, and D...University of Nottingham, Faraday Lecture Invited Lecture June 3-5, 2013 Quebec City, Quebec, Canada “Herbert P. Broida Prize Lecture: Probing

The first cyanobacterial infection of crustose coralline algae discovered on the reefs of Pohnpei, Micronesia

USGS Publications Warehouse

Aeby, Greta S.; Work, Thierry M.; Hughen, Konrad A.

2014-01-01

Crustose coralline algae (CCA) can cover substantial areas on living reef benthos (Adey et al. 1982, Keats et al. 1997), are important to reef integrity by acting to cement reefs together (Littler and Littler 1984), and serve as recruitment sites for coral larvae (Lasker and Kim 1996, Harrington et al. 2004, Price 2010).

A Psychometric Revision of the Asian Values Scale Using the Rasch Model

ERIC Educational Resources Information Center

Kim, Bryan S. K.; Hong, Sehee

2004-01-01

In this article, the 36-item Asian Values Scale (B. S. K. Kim, D. R. Atkinson, & P. H. Yang, 1999) was revised on the basis of G. Rasch's (1960) model and data from 618 Asian Americans. The results led to the establishment of a 25-item measure named the Asian Values Scale-Revised.

Higher Education: Handbook of Theory and Research. Volume II.

ERIC Educational Resources Information Center

Smart, John C., Ed.

Theory and research on the effectiveness of college operations are covered in 12 chapters. Current research on each topic is reviewed, with attention to conceptual and methodological issues, and an agenda for future research is offered. Chapter titles and authors are as follows: "Transformational Leadership in Colleges and Universities" (Kim S.…

Bring Engineering to Life: Pergola Design

ERIC Educational Resources Information Center

Dorrell, Abby; Berkeihiser, Mike

2014-01-01

The Family and Consumer Science (FCS) Department at Charles F. Patton Middle School in Kennett Square, Pennsylvania, planted a garden to provide students with an organic horticulture experience. Although the garden provided the FCS Department space to grow plants, Patton Middle School FCS teachers Betsy Ballard and Kim Hislert believed it wasn't…

Handbook of Parenting. Volume 2: Biology and Ecology of Parenting.

ERIC Educational Resources Information Center

Bornstein, Marc H., Ed.

Concerned with social settings and correlates of parenting, this volume, the second of four volumes on parenting deals specifically with the biology and the ecology of parenting. The volume consists of 12 chapters as follows: (1) "Hormonal Basis of Parenting in Mammals" (Jay S. Rosenblatt); (2) "Parenting in Primates" (Kim A.…

KSC-2013-4521

NASA Image and Video Library

2013-12-20

MORRO BAY, Calif. - An Erickson Sky Crane helicopter returns the SpaceX Dragon test article to Morro Bay, Cailf., following a test to evaluate the spacecraft's parachute deployment system. The test was part of a milestone under its Commercial Crew Integrated Capability agreement with NASA's Commercial Crew Program. Photo credit: NASA/Kim Shiflett

KSC-2013-4520

NASA Image and Video Library

2013-12-20

MORRO BAY, Calif. - An Erickson Sky Crane helicopter returns the SpaceX Dragon test article to Morro Bay, Cailf., following a test to evaluate the spacecraft's parachute deployment system. The test was part of a milestone under its Commercial Crew Integrated Capability agreement with NASA's Commercial Crew Program. Photo credit: NASA/Kim Shiflett

Health Insurance Literacy: How People Understand and Make Health Insurance Purchase Decisions

ERIC Educational Resources Information Center

Vardell, Emily Johanna

2017-01-01

The concept of health insurance literacy, which can be defined as "the extent to which consumers can make informed purchase and use decisions" (Kim, Braun, & Williams, 2013, p. 3), has only recently become a focus of health literacy research. Though employees have been making health insurance decisions for many years, the Affordable…

KSC-2012-5023

NASA Image and Video Library

2012-09-12

CAPE CANAVERAL, Fla. - Henry Taylor, from left to right, chief flight engineer on the Shuttle Carrier Aircraft, or SCA, Gary Ash, flight engineer, and Jeff Moultrie, pilot, look ahead to flying space shuttle Endeavour from NASA's Kennedy Space Center in Florida to Los Angeles for public display. Photo credit: NASA/Kim Shiflett

JPRS Report, Proliferation Issues

DTIC Science & Technology

1992-08-12

the North accept bilateral inspections in addition to IAEA inspec- ["News analysis" by staff reporter Kim Hye - won ] tions in order to clear...in the same wayJune 1992. The United and the European Community that we worked together to achieve world park status forhave each decided to offer $25