Macular telangiectasia type 2 (MacTel) in a 34-year-old patient

PubMed Central

Nicolai, Heleen; Wirix, Mieke; Spielberg, Leigh; Leys, Anita

2014-01-01

We report macular telangiectasia type 2 (MacTel) in a 34-year-old man, the youngest patient so far published with MacTel type 2. The patient presented with metamorphopsia and impaired reading ability. Diagnosis was based on bilateral abnormal macular autofluorescence, perifoveal telangiectasia with fluorescein angiographic hyperfluorescence without cystoid oedema, a small foveal avascular zone, asymmetric configuration of the foveal pit, disruptions in the inner segment/outer segment layer and hyper-reflective haze and spots in the outer nuclear layer. Although MacTel usually manifests with a slowly progressive decrease in visual acuity in the fifth to seventh decades of life, younger patients may occasionally be diagnosed with the disease. Awareness of subtle signs of the condition is essential for early diagnosis. PMID:25249218

Macular telangiectasia type 2 (MacTel) in a 34-year-old patient.

PubMed

Nicolai, Heleen; Wirix, Mieke; Spielberg, Leigh; Leys, Anita

2014-09-23

We report macular telangiectasia type 2 (MacTel) in a 34-year-old man, the youngest patient so far published with MacTel type 2. The patient presented with metamorphopsia and impaired reading ability. Diagnosis was based on bilateral abnormal macular autofluorescence, perifoveal telangiectasia with fluorescein angiographic hyperfluorescence without cystoid oedema, a small foveal avascular zone, asymmetric configuration of the foveal pit, disruptions in the inner segment/outer segment layer and hyper-reflective haze and spots in the outer nuclear layer. Although MacTel usually manifests with a slowly progressive decrease in visual acuity in the fifth to seventh decades of life, younger patients may occasionally be diagnosed with the disease. Awareness of subtle signs of the condition is essential for early diagnosis. 2014 BMJ Publishing Group Ltd.

Radiation measurement platform for balloon flights based on the TriTel silicon detector telescope

NASA Astrophysics Data System (ADS)

Zabori, Balazs; Hirn, Attila; Pazmandi, Tamas; Apathy, Istvan; Szanto, Peter; Deme, Sandor

Several measurements have been performed on the cosmic radiation field from the surface of the Earth up to the maximum altitudes of research airplanes. However the cosmic radiation field is not well known between 15 km and 30 km. Our experiment idea based on to study the radiation environment in the stratosphere. The main technical goals of our experiment were to test at first time the TriTel 3D silicon detector telescope system for future ISS missons and to develop a balloon technology platform for advanced cosmic radiation and dosimetric measurements. The main scientific goals were to give an assessment of the cosmic radiation field at the altitude of the BEXUS balloons, to use the TriTel system to determine dosimetric and radiation quantities during the ballon flight and to intercompare the TriTel and Pille results to provide a correction factor definition method for the Pille ISS measurements. To fulfil the scientific and technological objectives several different dosimeter systems were included in the experiment: an advanced version of the TriTel silicon detector telescope, Geiger-Müller counters, Pille passive thermoluminescent dosimeters and Solid State Nuclear Track Detectors. The experiment was built by students from Hungarian universities and flew on board the BEXUS stratospheric balloon in Northern Sweden (from ESRANGE Space Center). The float altitude was approximately 28.6 km and the total flight time was about 4 hours. The active instruments measured in real time and the ground team received the collected data continuously during the mission. The main technical goals were received since the operation of the TriTel experienced no failures and the experiment worked as it expected. This paper presents the scientific goals and results. From the TriTel measurements the deposited energy spectra, the Linear Energy Transfer spectra, the average quality factor of the cosmic radiation as well as the absorbed dose and the dose equivalent were determined for the

Absolute parameters of detached binaries in the southern sky - III: HO Tel

NASA Astrophysics Data System (ADS)

Sürgit, D.; Erdem, A.; Engelbrecht, C. A.; van Heerden, H. P.; Manick, R.

2017-07-01

We present the first radial velocity analysis of the southern eclipsing binary star HO Tel, based on spectra obtained at the South African Astronomical Observatory in 2013. The orbital solution of this neglected binary gave the quite large spectroscopic mass ratio of 0.921(±0.005). The V light curve from the All Sky Automated Survey (ASAS) and Walraven five-colour (WULBV) photometric light curves (Spoelstra and Van Houten 1972) were solved simultaneously using the Wilson-Devinney code supplemented by the Monte Carlo search method. The final photometric model describes HO Tel as a detached binary star where both component stars fill about three-quarters of their Roche limiting lobes. The masses and radii were found to be 1.88(±0.04) M⊙, 2.28(±0.15) R⊙ and 1.73(±0.04) M⊙, 2.08(±0.16) R⊙ for the primary and secondary components of the system, respectively. The distance to HO Tel was calculated as 282(±30) pc, taking into account interstellar extinction. The evolution case of HO Tel was also examined. Both components of the system are evolved main-sequence stars with an age of approximately 1.1 Gy, when compared to Geneva theoretical evolution models.

Fetal origins of the TEL-AML1 fusion gene in identical twins with leukemia

PubMed Central

Ford, Anthony M.; Bennett, Caroline A.; Price, Cathy M.; Bruin, M. C. A.; Van Wering, Elisabeth R.; Greaves, Mel

1998-01-01

The TEL (ETV6)−AML1 (CBFA2) gene fusion is the most common reciprocal chromosomal rearrangement in childhood cancer occurring in ≈25% of the most predominant subtype of leukemia— common acute lymphoblastic leukemia. The TEL-AML1 genomic sequence has been characterized in a pair of monozygotic twins diagnosed at ages 3 years, 6 months and 4 years, 10 months with common acute lymphoblastic leukemia. The twin leukemic DNA shared the same unique (or clonotypic) but nonconstitutive TEL-AML1 fusion sequence. The most plausible explanation for this finding is a single cell origin of the TEL-AML fusion in one fetus in utero, probably as a leukemia-initiating mutation, followed by intraplacental metastasis of clonal progeny to the other twin. Clonal identity is further supported by the finding that the leukemic cells in the two twins shared an identical rearranged IGH allele. These data have implications for the etiology and natural history of childhood leukemia. PMID:9539781

Government Venture Capital: A Case Study of the In-Q-Tel Model

DTIC Science & Technology

2004-03-23

their IP during the contracting process. “The folklore is that the government has a reputation for ‘ poaching ’ technology, either by getting a hook into...the introductions to individuals that can make a significant impact to a company’s business. Often these include members of government, industry...result of an In-Q-Tel-sponsored conference. Company 2 said that In-Q-Tel has made a significant impact by providing high-level introductions at

The function of the RNA-binding protein TEL1 in moss reveals ancient regulatory mechanisms of shoot development.

PubMed

Vivancos, Julien; Spinner, Lara; Mazubert, Christelle; Charlot, Florence; Paquet, Nicolas; Thareau, Vincent; Dron, Michel; Nogué, Fabien; Charon, Céline

2012-03-01

The shoot represents the basic body plan in land plants. It consists of a repeated structure composed of stems and leaves. Whereas vascular plants generate a shoot in their diploid phase, non-vascular plants such as mosses form a shoot (called the gametophore) in their haploid generation. The evolution of regulatory mechanisms or genetic networks used in the development of these two kinds of shoots is unclear. TERMINAL EAR1-like genes have been involved in diploid shoot development in vascular plants. Here, we show that disruption of PpTEL1 from the moss Physcomitrella patens, causes reduced protonema growth and gametophore initiation, as well as defects in gametophore development. Leafy shoots formed on ΔTEL1 mutants exhibit shorter stems with more leaves per shoot, suggesting an accelerated leaf initiation (shortened plastochron), a phenotype shared with the Poaceae vascular plants TE1 and PLA2/LHD2 mutants. Moreover, the positive correlation between plastochron length and leaf size observed in ΔTEL1 mutants suggests a conserved compensatory mechanism correlating leaf growth and leaf initiation rate that would minimize overall changes in plant biomass. The RNA-binding protein encoded by PpTEL1 contains two N-terminus RNA-recognition motifs, and a third C-terminus non-canonical RRM, specific to TEL proteins. Removal of the PpTEL1 C-terminus (including this third RRM) or only 16-18 amino acids within it seriously impairs PpTEL1 function, suggesting a critical role for this third RRM. These results show a conserved function of the RNA-binding PpTEL1 protein in the regulation of shoot development, from early ancestors to vascular plants, that depends on the third TEL-specific RRM.

The status of dermatoglyphics as a biomarker of Tel Hashomer camptodactyly syndrome: a review of the literature.

PubMed

Wijerathne, Buddhika T B; Meier, Robert J; Agampodi, Suneth B

2016-09-20

Tel Hashomer camptodactyly syndrome is a rare disease and only a few cases have been reported. Dermatoglyphics potentially provide relevant phenotypic biomarkers that were initially noted as a vital clinical feature of this disease. Dermatoglyphics possibly can indicate growth disturbances that took place during early fetal development at the time when epidermal ridges were being formed into discernable patterns. Consequently, these intrauterine effects might well have occurred in association with the expression of the Tel Hashomer camptodactyly syndrome. Therefore, this review was undertaken to provide, as far as we know, the first attempt to broadly assess dermatoglyphic features that are connected with the Tel Hashomer camptodactyly syndrome. If a developmental association between dermatoglyphics and Tel Hashomer camptodactyly can be firmly established, this would probably document that Tel Hashomer camptodactyly disease has its origins during the early fetal period. A systematic literature search was conducted using articles from PubMed (Medline), POPLINE, Trip Database, Cochrane Library, and gray literature up to 31 March 2015. The review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Fourteen relevant publications were included in the review. There were 23 cases of patients with Tel Hashomer camptodactyly syndrome that were described in these published articles. We reviewed the dermatoglyphics of 21 available cases out of all of the published and electronically available cases of Tel Hashomer camptodactyly. Eight cases reported whorls to be the most common digital pattern with an expected rise of ridge count. Two cases show significantly high frequencies of arch patterns. Further, there were increased numbers of palmar creases, along with abnormal flexion creases or other palmar dermatoglyphic abnormalities reported in all cases. This review highlighted the desirability of thoroughly observing and

TEL/AML1 positivity in childhood ALL: average or better prognosis? Czech Paediatric Haematology Working Group.

PubMed

Zuna, J; Hrusák, O; Kalinová, M; Muzíková, K; Starý, J; Trka, J

1999-01-01

The presence of TEL/AML1 fusion gene in childhood acute lymphoblastic leukaemia (ALL) defines a subgroup of patients with better than average outcome. However, the prognostic significance of this aberration has recently been disputed by the Berlin-Frankfurt-Münster (BFM) study group due to its relatively high incidence found in relapsed patients (19.6% and 21.9%, in two cohorts). In contrast, only four out of 45 (8.9%) unselected relapsed patients (all of whom had been treated according to BFM protocols) in the Czech Republic carry this fusion. From March 1995 to June 1998, 41 out of 190 (21.6%) newly diagnosed children with ALL were TEL/AML1-positive. There is a statistically significant difference between the incidence of TEL/AML1 fusion at diagnosis and at relapse within our group (P = 0.035). Interim analysis of the minimal residual disease (MRD) detection shows heterogeneity within the group of newly diagnosed TEL/AML1-positive leukaemias--10 out of 24 patients tested at the end of induction therapy had detectable levels of MRD. However, only one of these patients reached relapse-predictive level (10(-3)) of MRD. In conclusion, we corroborate low frequency of TEL/AML1 positivity among relapsed patients with ALL among Czech children who are treated by the BFM protocols. Moreover, we demonstrate different patterns of bone marrow clean-up in TEL/AML1-positive patients.

The TEL-AML1 fusion protein of acute lymphoblastic leukemia modulates IRF3 activity during early B-cell differentiation.

PubMed

de Laurentiis, A; Hiscott, J; Alcalay, M

2015-12-03

The t(12;21) translocation is the most common genetic rearrangement in childhood acute lymphoblastic leukemia (ALL) and gives rise to the TEL-AML1 fusion gene. Many studies on TEL-AML1 describe specific properties of the fusion protein, but a thorough understanding of its function is lacking. We exploited a pluripotent hematopoietic stem/progenitor cell line, EML1, and generated a cell line (EML-TA) stably expressing the TEL-AML1 fusion protein. EML1 cells differentiate to mature B-cells following treatment with IL7; whereas EML-TA display an impaired differentiation capacity and remain blocked at an early stage of maturation. Global gene expression profiling of EML1 cells at different stages of B-lymphoid differentiation, compared with EML-TA, identified the interferon (IFN)α/β pathway as a primary target of repression by TEL-AML1. In particular, expression and phosphorylation of interferon-regulatory factor 3 (IRF3) was decreased in EML-TA cells; strikingly, stable expression of IRF3 restored the capacity of EML-TA cells to differentiate into mature B-cells. Similarly, IRF3 silencing in EML1 cells by siRNA was sufficient to block B-lymphoid differentiation. The ability of TEL-AML1 to block B-cell differentiation and downregulate the IRF3-IFNα/β pathway was confirmed in mouse and human primary hematopoietic precursor cells (Lin- and CD34+ cells, respectively), and in a patient-derived cell line expressing TEL-AML1 (REH). Furthermore, treatment of TEL-AML1 expressing cells with IFNα/β was sufficient to overcome the maturation block. Our data provide new insight on TEL-AML1 function and may offer a new therapeutic opportunity for B-ALL.

New TEL Environments for Vocational Education--Teacher's Instructional Perspective

ERIC Educational Resources Information Center

Hämäläinen, Raija; Cattaneo, Alberto

2015-01-01

Modern vocational education is increasingly taking place in new technology-enhanced learning (TEL) settings. On the one hand, vocational education can benefit from the opportunities of technological development. On the other hand, such technologies may create new challenges for teachers. Therefore, there is a particular need to pay more attention…

Telomerase and Tel1p Preferentially Associate with Short Telomeres in S. cerevisiae

PubMed Central

Sabourin, Michelle; Tuzon, Creighton T.; Zakian, Virginia A.

2009-01-01

SUMMARY In diverse organisms, telomerase preferentially elongates short telomeres. We generated a single short telomere in otherwise wild-type (WT) S. cerevisiae cells. The binding of the positive regulators Ku and Cdc13p was similar at short and WT-length telomeres. The negative regulators Rif1p and Rif2p were present at the short telomere, although Rif2p levels were reduced. Two telomerase holoenzyme components, Est1p and Est2p, were preferentially enriched at short telomeres in late S/G2 phase, the time of telomerase action. Tel1p, the yeast ATM-like checkpoint kinase, was highly enriched at short telomeres from early S through G2 phase and even into the next cell cycle. Nonetheless, induction of a single short telomere did not elicit a cell-cycle arrest. Tel1p binding was dependent on Xrs2p and required for preferential binding of telomerase to short telomeres. These data suggest that Tel1p targets telomerase to the DNA ends most in need of extension. PMID:17656141

The T-TEL Method for Assessing Water, Sediment, and Chemical Connectivity

NASA Astrophysics Data System (ADS)

Ali, Genevieve; Oswald, Claire; Spence, Christopher; Wellen, Christopher

2018-02-01

The concept of connectivity has been the subject of a great deal of recent research and provided new insights and breakthroughs on runoff generation processes and watershed biogeochemistry. However, a consensus definition and cohesive mathematical framework that would permit the consistent quantification of hydrologic connectivity, the examination of the interrelationships between water and material (e.g., sediment and chemicals) connectivity, or rigorous study intercomparison, have not been presented by the water resource community. Building on previous conceptualizations and site-specific or process-specific metrics, this paper aimed to review the current state of science on hydrologic connectivity and its role in water-mediated connectivity of material such as solutes and sediment before introducing a conceptual and a mathematical connectivity assessment framework. These frameworks rely on the quantification of Time scales, Thresholds, Excesses and Losses related to water and water-mediated material transport dynamics and are referred to as the T-TEL method. Through a small case study, we show how the T-TEL method allows a wide range of properties to be quantified, namely the occurrence, frequency, duration, magnitude, and spatial extent of water and water-mediated material connectivity. We also propose a research agenda to refine the T-TEL method and ensure its usefulness for facilitating the research and management of connectivity in pristine and human-impacted landscapes.

CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability.

PubMed

Horejsí, Zuzana; Takai, Hiroyuki; Adelman, Carrie A; Collis, Spencer J; Flynn, Helen; Maslen, Sarah; Skehel, J Mark; de Lange, Titia; Boulton, Simon J

2010-09-24

TEL2 interacts with and is essential for the stability of all phosphatidylinositol 3-kinase-related kinases (PIKKs), but its mechanism of action remains unclear. Here, we show that TEL2 is constitutively phosphorylated on conserved serines 487 and 491 by casein kinase 2 (CK2). Proteomic analyses establish that the CK2 phosphosite of TEL2 confers binding to the R2TP/prefoldin-like complex, which possesses chaperon/prefoldin activities required during protein complex assembly. The PIH1D1 subunit of the R2TP complex binds directly to the CK2 phosphosite of TEL2 in vitro and is required for the TEL2-R2TP/prefoldin-like complex interaction in vivo. Although the CK2 phosphosite mutant of TEL2 retains association with the PIKKs and HSP90 in cells, failure to interact with the R2TP/prefoldin-like complex results in instability of the PIKKs, principally mTOR and SMG1. We propose that TEL2 acts as a scaffold to coordinate the activities of R2TP/prefoldin-like and HSP90 chaperone complexes during the assembly of the PIKKs. Copyright © 2010 Elsevier Inc. All rights reserved.

Teaching Gender in Israel: Experiences at the Tel Aviv University

ERIC Educational Resources Information Center

Fenster, Tovi

2011-01-01

This paper examines the ways in which neoliberal economic policies are affecting academic work in Israeli universities, prioritizing programs that can generate their own funding, External philanthropic support from North America has enabled creation of an interdisciplinary Women and Gender Studies Program at Tel Aviv University that draws…

Factors Affecting Academics' Involvement in TEL Continuing Professional Development (CPD)

ERIC Educational Resources Information Center

AlMutlaq, Abdullah; Dimitriadi, Yota; McCrindle, Rachel

2017-01-01

Reinforcing the level of essentiality of understanding the factors that influence the involvement in TEL-oriented CPD and the challenges to the sustained expansion of their expertise not only for academics, but also professional bodies and educational developer for effective integration of digital technologies in teaching and learning remains is…

Novel Connections Between DNA Replication, Telomere Homeostasis, and the DNA Damage Response Revealed by a Genome-Wide Screen for TEL1/ATM Interactions in Saccharomyces cerevisiae

PubMed Central

Piening, Brian D.; Huang, Dongqing; Paulovich, Amanda G.

2013-01-01

Tel1 is the budding yeast ortholog of the mammalian tumor suppressor and DNA damage response (DDR) kinase ATM. However, tel1-Δ cells, unlike ATM-deficient cells, do not exhibit sensitivity to DNA-damaging agents, but do display shortened (but stably maintained) telomere lengths. Neither the extent to which Tel1p functions in the DDR nor the mechanism by which Tel1 contributes to telomere metabolism is well understood. To address the first question, we present the results from a comprehensive genome-wide screen for genetic interactions with tel1-Δ that cause sensitivity to methyl methanesulfonate (MMS) and/or ionizing radiation, along with follow-up characterizations of the 13 interactions yielded by this screen. Surprisingly, many of the tel1-Δ interactions that confer DNA damage sensitivity also exacerbate the short telomere phenotype, suggesting a connection between these two phenomena. Restoration of normal telomere length in the tel1-Δ xxx-Δ mutants results in only minor suppression of the DNA damage sensitivity, demonstrating that the sensitivity of these mutants must also involve mechanisms independent of telomere length. In support of a model for increased replication stress in the tel1-Δ xxx-Δ mutants, we show that depletion of dNTP pools through pretreatment with hydroxyurea renders tel1-Δ cells (but not wild type) MMS-sensitive, demonstrating that, under certain conditions, Tel1p does indeed play a critical role in the DDR. PMID:23378069

Survey of Oral Health Awareness in Neuchâtel 9th Graders.

PubMed

Neuhaus, Klaus W; Müller, Magali E; Lussi, Adrian

The oral health habits of pupils had not yet been analyzed for the canton of Neuchâtel. A questionnaire was provided to 9th grade high school pupils (final year) of the three schools located in the Neuchâtel area to asses both oral health knowledge and habits in this connection. The average age was 15.5±0.8 years, and 78.1% of the questionnaires were returned. The prophylaxis program was conducted for a total of 4.5 h during pupils’ entire time at school. The results showed that both knowledge and oral health habits could be improved. As a positive outcome, 99% of the pupils brush their teeth before going to bed. Comparisons with similar 10-year-old studies from other cantons (Bern, Vaud) showed major differences in knowledge, for example on the importance of fluoridation. Only 54% of the pupils in Neuchâtel knew that fluoride offers some protection against caries, in spite of the fact that 89% thought that brushing with fluoridated toothpaste protects against caries. Most of the pupils used a fluoridated toothpaste. Furthermore, we found that self-reported sugar consumption was correlated with caries experience, but brushing frequency was not. We recommend introducing a review course for pupils in their last school year, in order to practice interdental cleaning, redefine appropriate, tooth-friendly snacks, and emphasize the importance of regular dental check-ups.

The Dimeric Architecture of Checkpoint Kinases Mec1ATR and Tel1ATM Reveal a Common Structural Organization.

PubMed

Sawicka, Marta; Wanrooij, Paulina H; Darbari, Vidya C; Tannous, Elias; Hailemariam, Sarem; Bose, Daniel; Makarova, Alena V; Burgers, Peter M; Zhang, Xiaodong

2016-06-24

The phosphatidylinositol 3-kinase-related protein kinases are key regulators controlling a wide range of cellular events. The yeast Tel1 and Mec1·Ddc2 complex (ATM and ATR-ATRIP in humans) play pivotal roles in DNA replication, DNA damage signaling, and repair. Here, we present the first structural insight for dimers of Mec1·Ddc2 and Tel1 using single-particle electron microscopy. Both kinases reveal a head to head dimer with one major dimeric interface through the N-terminal HEAT (named after Huntingtin, elongation factor 3, protein phosphatase 2A, and yeast kinase TOR1) repeat. Their dimeric interface is significantly distinct from the interface of mTOR complex 1 dimer, which oligomerizes through two spatially separate interfaces. We also observe different structural organizations of kinase domains of Mec1 and Tel1. The kinase domains in the Mec1·Ddc2 dimer are located in close proximity to each other. However, in the Tel1 dimer they are fully separated, providing potential access of substrates to this kinase, even in its dimeric form. © 2016 by The American Society for Biochemistry and Molecular Biology, Inc.

Flow Quality for Turbine Engine Loads Simulator (TELS) Facility

DTIC Science & Technology

1980-06-01

2.2 GAS INGESTION A mathematical simulation of the turbojet engine and jet deflector was formulated to estimate the severity of the recirculating...3. Swain. R. L. and Mitchell, J. G. "’Smlulatlon of Turbine Engine Operational Loads." Journal of Aircraft Vol. 15, No. 6, June 1978• 4. Ryan, J...3 AEDC-TR-79-83 ~...~ i ,i g - Flow Quality for Turbine Engine Loads Simulator (TELS) Facility R..I. Schulz ARO, Inc. June 1980

Chromosome 12p deletions in TEL-AML1 childhood acute lymphoblastic leukemia are associated with retrotransposon elements and occur postnatally

PubMed Central

Hofmann, Jerry; Kang, Michelle; Selzer, Rebecca; Green, Roland; Zhou, Mi; Zhong, Sheng; Zhang, Luoping; Smith, Martyn T.; Marsit, Carmen; Loh, Mignon; Buffler, Patricia; Yeh, Ru-Fang

2008-01-01

TEL-AML1 (ETV6-RUNX1) is the most common translocation in the childhood leukemias, and is a prenatal mutation in most children. This translocation has been detected at a high rate among newborns (∼1%); therefore the rate-limiting event for leukemia appears to be secondary mutations. A frequent such mutation in this subtype is partial deletion of chromosome 12p, trans from the translocation. Nine del(12p) breakpoints within six leukemia cases were sequenced to explore the etiology of this genetic event, and most involved cryptic sterile translocations. Twelve of 18 del(12p) parent sequences involved in these breakpoints were located in repeat regions (8 of these in Long Interspersed Nuclear Elements, or LINEs). This stands in contrast to TEL-AML1, in which only 21 of 110 previously assessed breakpoints (19%) occur in DNA repeats (P = 0.0001). An exploratory assessment of archived neonatal blood cards (ANB cards) revealed significantly more LINE CpG methylation in individuals at birth who were later diagnosed with TEL-AML1 leukemia, compared to individuals who did not contract leukemia (P = 0.01). Nontemplate nucleotides were also more frequent in del(12p) than in TEL-AML1 junctions (P = 0.004) suggesting formation by terminal deoxynucleotidyl transferase. Assessment of six ANB cards indicated that no del(12p) rearrangements backtracked to birth, although two of these patients were previously positive for TEL-AML1 using the same assay with comparable sensitivity. These data are compatible with the a two-stage natural history: TEL-AML1 occurs prenatally, and del(12p) occurs postnatally in more mature cells with a structure that suggests the involvement of retrotransposon instability. PMID:19047175

Instructional Design or School Politics? A Discussion of "Orchestration" in TEL Research

ERIC Educational Resources Information Center

Perrotta, C.; Evans, M. A.

2013-01-01

This paper argues that the emphasis on orchestration as a metaphor for teaching in technology-enhanced learning (TEL) environments, featured in recent academic discussions, is an opportunity to broaden the scope of the inquiry into educational technology. Drawing on sociological literature and research that investigated the systemic factors that…

Multifunctional Role of ATM/Tel1 Kinase in Genome Stability: From the DNA Damage Response to Telomere Maintenance

PubMed Central

2014-01-01

The mammalian protein kinase ataxia telangiectasia mutated (ATM) is a key regulator of the DNA double-strand-break response and belongs to the evolutionary conserved phosphatidylinositol-3-kinase-related protein kinases. ATM deficiency causes ataxia telangiectasia (AT), a genetic disorder that is characterized by premature aging, cerebellar neuropathy, immunodeficiency, and predisposition to cancer. AT cells show defects in the DNA damage-response pathway, cell-cycle control, and telomere maintenance and length regulation. Likewise, in Saccharomyces cerevisiae, haploid strains defective in the TEL1 gene, the ATM ortholog, show chromosomal aberrations and short telomeres. In this review, we outline the complex role of ATM/Tel1 in maintaining genomic stability through its control of numerous aspects of cellular survival. In particular, we describe how ATM/Tel1 participates in the signal transduction pathways elicited by DNA damage and in telomere homeostasis and its importance as a barrier to cancer development. PMID:25247188

The Gemini NICI Planet-finding Campaign: Discovery of a Close Substellar Companion to the Young Debris Disk Star PZ Tel

NASA Astrophysics Data System (ADS)

Biller, Beth A.; Liu, Michael C.; Wahhaj, Zahed; Nielsen, Eric L.; Close, Laird M.; Dupuy, Trent J.; Hayward, Thomas L.; Burrows, Adam; Chun, Mark; Ftaclas, Christ; Clarke, Fraser; Hartung, Markus; Males, Jared; Reid, I. Neill; Shkolnik, Evgenya L.; Skemer, Andrew; Tecza, Matthias; Thatte, Niranjan; Alencar, Silvia H. P.; Artymowicz, Pawel; Boss, Alan; de Gouveia Dal Pino, Elisabete; Gregorio-Hetem, Jane; Ida, Shigeru; Kuchner, Marc J.; Lin, Douglas; Toomey, Douglas

2010-09-01

We report the discovery of a tight substellar companion to the young solar analog PZ Tel, a member of the β Pic moving group observed with high-contrast adaptive optics imaging as part of the Gemini Near-Infrared Coronagraphic Imager Planet-Finding Campaign. The companion was detected at a projected separation of 16.4 ± 1.0 AU (0farcs33 ± 0farcs01) in 2009 April. Second-epoch observations in 2010 May demonstrate that the companion is physically associated and shows significant orbital motion. Monte Carlo modeling constrains the orbit of PZ Tel B to eccentricities >0.6. The near-IR colors of PZ Tel B indicate a spectral type of M7 ± 2 and thus this object will be a new benchmark companion for studies of ultracool, low-gravity photospheres. Adopting an age of 12+8 -4 Myr for the system, we estimate a mass of 36 ± 6 M Jup based on the Lyon/DUSTY evolutionary models. PZ Tel B is one of the few young substellar companions directly imaged at orbital separations similar to those of giant planets in our own solar system. Additionally, the primary star PZ Tel A shows a 70 μm emission excess, evidence for a significant quantity of circumstellar dust that has not been disrupted by the orbital motion of the companion. Based on observations obtained at the Gemini Observatory, which is operated by the Association of Universities for Research in Astronomy, Inc., under a cooperative agreement with the NSF on behalf of the Gemini partnership: the National Science Foundation (United States), the Science and Technology Facilities Council (United Kingdom), the National Research Council (Canada), CONICYT (Chile), the Australian Research Council (Australia), Ministério da Ciência e Tecnologia (Brazil), and Ministerio de Ciencia, Tecnología e Innovación Productiva (Argentina).

Disparity of spectral behavior of RR Tel and RX Pup in the UV

NASA Astrophysics Data System (ADS)

Sanad, M. R.

2010-07-01

The main aim of this study is to use archival low-dispersion spectra from the International Ultraviolet Explorer (IUE) in an attempt to follow up the spectral behavior of two symbiotic Mira systems RR Tel and RX Pup of the period from 1978-1995 and 1979-1989 for two systems respectively. We concentrated on studying N IV 1486 Å intercombination line, coming from the emission nebulae ( Bryan and Kwok, 1991; Muerset et al., 1991; Murset and Nussbaumer, 1994), by calculating the line fluxes and line widths of N IV 1486 Å. We found that there is a disparity of spectral variability for these physical parameters at different times for both systems. For RR Tel, both line fluxes and line widths are increasing with the phase, while for RX Pup, both line fluxes and line widths are decreasing with the phase. There is a relation between the parameters of this emission line (line flux, line width) and phase, which we attribute to the variations of temperature of the emission nebulae at different times, as a result of the activity of the hot component.

Renata Adler Memorial Research Center for Child Welfare and Protection, Tel-Aviv University

ERIC Educational Resources Information Center

Ronen, Tammie

2011-01-01

The Renata Adler Memorial Research Center for Child Welfare and Protection operates within the Bob Shapell School of Social Work at Tel-Aviv University in Israel. The main aims of this research center are to facilitate study and knowledge about the welfare of children experiencing abuse or neglect or children at risk and to link such knowledge to…

Multi-disciplinary study for the exploration of deep low enthalpy geothermal reservoirs, Neuchâtel, Switzerland

NASA Astrophysics Data System (ADS)

Mauri, G.; Abdelfettah, Y.; Negro, F.; Schill, E.; Vuataz, F.

2011-12-01

The authorities of the canton of Neuchâtel, in the Western part of Switzerland, are willing to develop geothermal energy for district heating in the two main cities of the canton: Neuchâtel, located along the Lake of Neuchâtel, and La Chaux-de-Fonds situated in a high valley of the Jura Massif. The geology of both areas is linked to the Jura Range and present complex structures, where the landscape is composed of anticlines associated with overthrust faults, which are overcut by strike-slip fault and secondary faulting events. The rock formations go from the Trias, which forms the detachment layer, up to the Quaternary rock. Bedrocks are mainly composed of limestones and marls, which can reach a thickness of several hundreds meters. The three main deep aquifers investigated in this area, from the shallowest (≤ 400 m below surface) to deepest (< 2000 m), are the Malm, the Dogger and the Muschelkalk. The estimated temperatures, based on previous studies, should range between 20 to 65 oC, which are function of depth, elevation and groundwater velocity. The expected low temperature is mainly due to the presence of karstic systems, which drains the heat towards the low elevation of the basin. The present study is based on gravimetry surveys, 3D geological models and 3D gravimetry models to best characterize the underground structures and to find areas where the rock properties would be favourable to geothermal exploitation. This means targets where permeability and porosity are high in the potential aquifers, allowing a significant flow at the future production wells. The results indicate that gravity anomalies are associated with both shallow and deep geological structures in the two exploration sites and that high resolution of dense grid gravity measurements combined with realistic 3D models of the geological structures allow to characterize interesting features for deep geothermal exploration. Gravity corrections were carried out with a computing code using

Diffusion of Web Supported Instruction in Higher Education--The Case of Tel-Aviv University

ERIC Educational Resources Information Center

Soffer, Tal; Nachmias, Rafi; Ram, Judith

2010-01-01

This paper describes a study that focused on long-term web-supported learning diffusion among lecturers at Tel Aviv University (TAU), from an organizational point of view. The theoretical models we used to examine this process are Rogers' model for "Diffusion of Innovation" (1995) and Bass's "Diffusion Model" (1969). The study…

First photometric study of two southern eclipsing binaries IS Tel and DW Aps

NASA Astrophysics Data System (ADS)

Özer, S.; Sürgit, D.; Erdem, A.; Öztürk, O.

2017-02-01

The paper presents the first photometric analysis of two southern eclipsing binary stars, IS Tel and DW Aps. Their V light curves from the All Sky Automated Survey were modelled by using Wilson-Devinney method. The final models give these two Algol-like binary stars as having detached configurations. Absolute parameters of the components of the systems were also estimated.

A Delphi Study on Technology Enhanced Learning (TEL) Applied on Computer Science (CS) Skills

ERIC Educational Resources Information Center

Porta, Marcela; Mas-Machuca, Marta; Martinez-Costa, Carme; Maillet, Katherine

2012-01-01

Technology Enhanced Learning (TEL) is a new pedagogical domain aiming to study the usage of information and communication technologies to support teaching and learning. The following study investigated how this domain is used to increase technical skills in Computer Science (CS). A Delphi method was applied, using three-rounds of online survey…

Mobile health for early retention in HIV care: a qualitative study in Kenya (WelTel Retain)

PubMed Central

Smillie, Kirsten; Van Borek, Natasha; van der Kop, Mia L; Lukhwaro, Abigael; Li, Neville; Karanja, Sarah; Patel, Anik R; Ojakaa, David; Lester, Richard T

2017-01-01

Many people newly diagnosed with HIV are lost to follow-up before timely initiation of antiretroviral therapy (ART). A randomised controlled trial (RCT), WelTel Kenya1, demonstrated the effectiveness of the WelTel text messaging intervention to improve clinical outcomes among patients initiating ART. In preparation for WelTel Retain, an RCT that will evaluate the effect of the intervention to retain patients in care immediately following HIV diagnosis, we conducted an informative qualitative study with people living with HIV (n = 15) and healthcare providers (HCP) (n = 5) in October 2012. Study objectives included exploring the experiences of people living with HIV who have attempted to engage in HIV care, the use of cell phones in everyday life, and perceptions of communicating via text message with HCP. Participants were recruited through convenience sampling. Semi-structured, qualitative interviews were conducted and recorded, transcribed verbatim and analysed using NVivo software. Analysis was guided by the Theory of Reasoned Action and the Technology Acceptance Model. Results indicate that while individuals have many motivators for engaging in care after diagnosis, structural and individual barriers including poverty, depression and fear of stigma prevent them from doing so. All participants had access to a mobile phone, and most were comfortable communicating through text messages, or were willing to learn. Both people living with HIV and HCP felt that increased communication via the text messaging intervention has the potential to enable early identification of problems, leading to timely problem solving that may improve retention and engagement in care during the first year after diagnosis. PMID:25555099

Mobile health for early retention in HIV care: a qualitative study in Kenya (WelTel Retain).

PubMed

Smillie, Kirsten; Van Borek, Natasha; van der Kop, Mia L; Lukhwaro, Abigael; Li, Neville; Karanja, Sarah; Patel, Anik R; Ojakaa, David; Lester, Richard T

2014-01-01

Many people newly diagnosed with HIV are lost to follow-up before timely initiation of antiretroviral therapy (ART). A randomised controlled trial (RCT), WelTel Kenya1, demonstrated the effectiveness of the WelTel text messaging intervention to improve clinical outcomes among patients initiating ART. In preparation for WelTel Retain, an RCT that will evaluate the effect of the intervention to retain patients in care immediately following HIV diagnosis, we conducted an informative qualitative study with people living with HIV (n = 15) and healthcare providers (HCP) (n = 5) in October 2012. Study objectives included exploring the experiences of people living with HIV who have attempted to engage in HIV care, the use of cell phones in everyday life, and perceptions of communicating via text message with HCP. Participants were recruited through convenience sampling. Semi-structured, qualitative interviews were conducted and recorded, transcribed verbatim and analysed using NVivo software. Analysis was guided by the Theory of Reasoned Action and the Technology Acceptance Model. Results indicate that while individuals have many motivators for engaging in care after diagnosis, structural and individual barriers including poverty, depression and fear of stigma prevent them from doing so. All participants had access to a mobile phone, and most were comfortable communicating through text messages, or were willing to learn. Both people living with HIV and HCP felt that increased communication via the text messaging intervention has the potential to enable early identification of problems, leading to timely problem solving that may improve retention and engagement in care during the first year after diagnosis.

[Simplicia and medical containers from the Jesuit pharmacy in Telč].

PubMed

Hamrlová, Anna

2017-01-01

The Jesuit pharmacy in Telč was founded after 1657 within the premises of the Jesuit cloister; it survived the dissolution of Jesuits in 1773 and thanks to its purchase by the last pharmacist Ignac Lyro it was relocated to one of the houses in the square. During the stocktaking of the property and its sale, a detailed inventory of pharmacy equipment was recorded, including cabinets, laboratory tools, ingredients or drugs. The inventory is divided into parts of ingredients and prepared medications, the last lists recording the tools and containers for its preparation, production and preservation. The ingredients contain various parts of plants, minerals, precious stones or even parts of animals. The list is written mainly in the alphabetical order, in some cases with specified types of groups. Every item is provided with information about its price and quantity. Many ingredients originated from overseas countries, the areas of Jesuit missionary activities. Of the former rich equipment, only three pharmacy cabinets and a few containers, mainly veneer boxes and ceramic drug jars, have survived. All these parts together with the inventory give us a comparatively clear notion about the equipment and even facilities of the Jesuit apothecary in Telč, which sold items from different parts of the world. The Jesuit convent seems to be an important centre for town inhabitants not only in the 18th century; its legacy has remained in the local pharmacy till today.Key words: pharmacy Societas Jesus 18th century medications medical containers.

Organizing the Library to Suit the Undergraduates' Information Gathering Behavior at the Tel-Hai Academic College in Israel

ERIC Educational Resources Information Center

Chai, Iris

2007-01-01

The study examined the factors influencing information gathering behavior of undergraduates at Tel-Hai Academic College, so that library services can cope effectively with this behavior. Related to the findings, we changed our circulation desk to become a "one stop shop" for directions to all library information.

76 FR 13438 - AccessTel, Inc., American Asset Management Corp., DME Interactive Holdings, Inc., DocuPort, Inc...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-11

... SECURITIES AND EXCHANGE COMMISSION [File No. 500-1] AccessTel, Inc., American Asset Management Corp., DME Interactive Holdings, Inc., DocuPort, Inc., and iCarbon Corp., Order of Suspension of Trading March 8, 2011. It appears to the Securities and Exchange Commission that there is a lack of current and accurate information concerning the...

77 FR 39559 - In the Matter of AngelCiti Entertainment, Inc., BodyTel Scientific, Inc., Clearant, Inc...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-03

...., BodyTel Scientific, Inc., Clearant, Inc., DataMetrics Corp., and Green Energy Group, Inc. (a/k/a eCom eCom.Com, Inc.); Order of Suspension of Trading June 29, 2012. It appears to the Securities and... of current and accurate information concerning the securities of Green Energy Group, Inc. (a/k/a eCom...

Indications of stellar prominence oscillations on fast rotating stars: the cases of HK Aqr and PZ Tel

NASA Astrophysics Data System (ADS)

Leitzinger, M.; Odert, P.; Zaqarashvili, T. V.; Greimel, R.; Hanslmeier, A.; Lammer, H.

2016-11-01

We present the analysis of six nights of spectroscopic monitoring of two young and fast rotating late-type stars, namely the dMe star HK Aqr and the dG/dK star PZ Tel. On both stars, we detect absorption features reminiscent of signatures of corotating cool clouds or prominences visible in Hα. Several prominences on HK Aqr show periodic variability in the prominence tracks which follow a sinusoidal motion (indication of prominence oscillations). On PZ Tel, we could not find any periodic variability in the prominence tracks. By fitting sinusoidal functions to the prominence tracks, we derive amplitudes and periods which are similar to those of large-amplitude oscillations seen in solar prominences. In one specific event, we also derive a periodic variation of the prominence track in the Hβ spectral line which shows an anti-phase variation with the one derived for the Hα spectral line. Using these parameters and estimated mass density of a prominence on HK Aqr, we derive a minimum magnetic field strength of ˜2 G. The relatively low strength of the magnetic field is explained by the large height of this stellar prominence (≥ 0.67 stellar radii above the surface).

Personalized drug discovery: HCA approach optimized for rare diseases at Tel Aviv University.

PubMed

Solmesky, Leonardo J; Weil, Miguel

2014-03-01

The Cell screening facility for personalized medicine (CSFPM) at Tel Aviv University in Israel is devoted to screening small molecules libraries for finding new drugs for rare diseases using human cell based models. The main strategy of the facility is based on smartly reducing the size of the compounds collection in similarity clusters and at the same time keeping high diversity of pharmacophores. This strategy allows parallel screening of several patient derived - cells in a personalized screening approach. The tested compounds are repositioned drugs derived from collections of phase III and FDA approved small molecules. In addition, the facility carries screenings using other chemical libraries and toxicological characterizations of nanomaterials.

Health care providers' perspectives on a weekly text-messaging intervention to engage HIV-positive persons in care (WelTel BC1).

PubMed

Murray, Melanie C M; O'Shaughnessy, Sara; Smillie, Kirsten; Van Borek, Natasha; Graham, Rebecca; Maan, Evelyn J; van der Kop, Mia L; Friesen, Karen; Albert, Arianne; Levine, Sarah; Pick, Neora; Ogilvie, Gina; Money, Deborah; Lester, Richard

2015-10-01

Though evidence shows that Mobile health (mHealth) interventions can improve adherence and viral load in HIV-positive persons, few have studied the health care providers' (HCP) perspective. We conducted a prospective mixed methods pilot study using the WelTel intervention wherein HIV-positive participants (n = 25) received weekly interactive text messages for 6 months. Text message response rate and topic data were collected to illustrate the HCP experience. The aim of this study is to explore intervention acceptability and feasibility from the HCP perspective through a baseline focus group and end of study interviews with HCP impacted by the intervention. Interview data were thematically coded using the Technology Acceptance Model. HCPs identified that the WelTel intervention engaged patients in building relationships, while organizing and streamlining existing mHealth efforts and dealing with privacy issues. HCPs recognized that although workload would augment initially, intervention benefits were many, and went beyond simply improving HIV viral load.

Operationalizing mHealth to improve patient care: a qualitative implementation science evaluation of the WelTel texting intervention in Canada and Kenya.

PubMed

Bardosh, Kevin Louis; Murray, Melanie; Khaemba, Antony M; Smillie, Kirsten; Lester, Richard

2017-12-06

Mobile health (mHealth) applications have proliferated across the globe with much enthusiasm, although few have reached scale and shown public health impact. In this study, we explored how different contextual factors influenced the implementation, effectiveness and potential for scale-up of WelTel, an easy-to-use and evidence-based mHealth intervention. WelTel uses two-way SMS communication to improve patient adherence to medication and engagement in care, and has been developed and tested in Canada and Kenya. We used a comparative qualitative case study design, which drew on 32 key informant interviews, conducted in 2016, with stakeholders involved in six WelTel projects. Our research was guided by the Consolidated Framework for Implementation Research (CFIR), a meta-theoretical framework, and our analysis relied on a modified approach to grounded theory, which allowed us to compare findings across these projects. We found that WelTel had positive influences on the "culture of care" at local clinics and hospitals in Canada and Kenya, many of which stretched beyond the immediate patient-client relationship to influence wider organizational systems. However, these were mediated by clinician norms and practices, the availability of local champion staff, the receptivity and capacity of local management, and the particular characteristics of the technology platform, including the ability for adaptation and co-design. We also found that scale-up was influenced by different forms of data and evidence, which played important roles in legitimization and partnership building. Even with robust research evidence, scale-up was viewed as a precarious and uncertain process, embedded within the wider politics and financing of Canadian and Kenyan health systems. Challenges included juggling different interests, determining appropriate financing pathways, maintaining network growth, and "packaging" the intervention for impact and relevance. Our comparative case study, of a unique

Knowledge of elementary school teachers in Tel-Aviv, Israel, regarding emergency care of dental injuries.

PubMed

Fux-Noy, Avia; Sarnat, Haim; Amir, Erica

2011-08-01

Immediate management of traumatized teeth is often critical to the prognosis of the teeth. Most of the traumatic dental injuries occur at home, followed by school. There is a high probability that first aid would be given by lay people such as parents, teachers, or coaches. Knowledge of those people regarding emergency management of dental trauma is crucial for better prognosis. To investigate: (i) the knowledge of elementary school teachers regarding traumatic dental injuries to permanent teeth and emergency treatment, (ii) their source of information, and (iii) the demand for more education in dental trauma. A three-part questionnaire comprised of questions regarding demographic data, attitude, and knowledge about dental injuries was distributed to teachers in 12 elementary schools in the Tel-Aviv area, Israel. The average knowledge score was 4.59 (in a scale of 0-10). Three individual predictors significantly improved the respondents' knowledge: being in the 35-49-year age group (P-value = 0.042), those who had children themselves (P-value = 0.002) and those who had previous experience with trauma (P-value = 0.049). There was no correlation between the demand for further education in dental trauma and knowledge score. The knowledge regarding management of traumatic dental injuries in a group of teachers in the Tel-Aviv area is inadequate. Educational programs as well as addition to the curriculum are necessary to improve their emergency management of traumatic dental injuries and provide better protection to the students. © 2011 John Wiley & Sons A/S.

Transitioning to Teacher: Uncertainty as a Game of Dramatic Hats

ERIC Educational Resources Information Center

Sinner, Anita

2012-01-01

Nathalie's experience of becoming a teacher demonstrates how a counter-narrative contributes to negotiating dominant discourses that propagate stories of uniformity and reinforce the status quo within the teaching profession. By offering an alternate perspective of teacher culture as a liminal space, uncertainty symbolizes Nathalie's transition to…

DEFECTS IN CERVICAL VERTEBRAE IN BORIC ACID-EXPOSED RAT EMBRYOS ARE ASSOCIATED WITH ANTERIOR SHIFTS OF HOX GENE EXPRESSION DOMAINS

EPA Science Inventory

Defects in cervical vertebrae in boric acid-exposed rat embryos are associated with anterior shifts of hox gene expression domains

Nathalie Wery,1 Michael G. Narotsky,2 Nathalie Pacico,1 Robert J. Kavlock,2 Jacques J. Picard,1 AND Francoise Gofflot,1*
1Unit of Developme...

In-Q-Tel, the strategic investment firm for the U.S. Intelligence Community

NASA Astrophysics Data System (ADS)

Ulvick, S. J.; Tighe, D. W.

2008-04-01

In-Q-Tel is a strategic investment firm that works to identify, adapt, and deliver innovative technology solutions to support the missions of the Central Intelligence Agency and the broader U.S. Intelligence Community (IC). Launched by the CIA in 1999 as a private, independent, not-for-profit organization, IQT's mission is to identify and partner with companies developing cutting-edge technologies that serve the national security interests of the United States. Working from an evolving strategic blueprint defining the Intelligence Community's critical technology needs, IQT engages with entrepreneurs, growth companies, researchers, and venture capitalists to deliver technologies that provide superior capabilities for the CIA and the broader IC. To date, IQT has reviewed more than 6,300 business proposals, invested in more than 100 companies, and delivered more than 140 technology solutions to the U.S. Intelligence Community.

The Dialectics of Assimilation and Multiculturalism: The Case of Children of Refugees and Migrant Workers in the Bialik-Rogozin School, Tel Aviv

ERIC Educational Resources Information Center

Dvir, Nurit; Aloni, Nimrod; Harari, Dor

2015-01-01

This paper focuses on children of refugees and migrant workers from 48 countries who study together in one multicultural school in the city of Tel Aviv, Israel. The context of our study is the current ethos of globalisation and within it the phenomenon of vast migrations and creation of intercultural social realities. The aims of the study were to…

[Statistics of the activities of a veterinarian from the Canton of Neuchâtel from the 19th century].

PubMed

Rutti, A

2017-01-01

Abraham Buehler wrote a statistical sketch of his activity as a practitioner during the years 1855 to 1861 in "Les Verrières" in the Swiss Canton of Neuchâtel. He included charts relating to diseases observed in different species such as horses, cows, goats, sheep, pigs and dogs. He described the evolution of the foot and mouth epidemic in the region during the years 1855 and 1856. Abraham Buehler stated that with this work he aimed to encourage his colleagues to also collect data.

Expanding the Scope of Anatomical Sciences: The Case of "Human Evolution--The Fossil Evidence" Course at the Sackler School of Medicine, Tel-Aviv University

ERIC Educational Resources Information Center

Notzer, Netta; Abramovitz, Ruth

2012-01-01

The Anatomy Department at Tel-Aviv University Medical School offers its students an elective course of 26 didactic hours on human evolution. The course is open to students from all faculties, who must fulfill all academic requirements, without a prerequisite of a background in anatomy. Approximately 120 students attend annually, a third of them…

TelAP1 links telomere complexes with developmental expression site silencing in African trypanosomes

PubMed Central

Reis, Helena; Schwebs, Marie; Dietz, Sabrina; Janzen, Christian J; Butter, Falk

2018-01-01

Abstract During its life cycle, Trypanosoma brucei shuttles between a mammalian host and the tsetse fly vector. In the mammalian host, immune evasion of T. brucei bloodstream form (BSF) cells relies on antigenic variation, which includes monoallelic expression and periodic switching of variant surface glycoprotein (VSG) genes. The active VSG is transcribed from only 1 of the 15 subtelomeric expression sites (ESs). During differentiation from BSF to the insect-resident procyclic form (PCF), the active ES is transcriptionally silenced. We used mass spectrometry-based interactomics to determine the composition of telomere protein complexes in T. brucei BSF and PCF stages to learn more about the structure and functions of telomeres in trypanosomes. Our data suggest a different telomere complex composition in the two forms of the parasite. One of the novel telomere-associated proteins, TelAP1, forms a complex with telomeric proteins TbTRF, TbRAP1 and TbTIF2 and influences ES silencing kinetics during developmental differentiation. PMID:29385523

Seroprevalence of Antibodies against Human Herpesvirus 8 in a Population of Renal Transplant Recipients at Hôtel-Dieu de Québec Hospital

PubMed Central

Delorme, S.; Houde, I.; Deschênes, L.

2003-01-01

We conducted a seroepidemiologic study to determine the prevalence of anti-human herpesvirus 8 antibodies in a renal transplant population at Hôtel-Dieu de Québec Hospital. Testing for immunoglobulin G antibodies against lytic and latent antigens was performed on serum samples from 150 renal transplant patients. Human immunodeficiency virus-positive patients with confirmed Kaposi's sarcoma were used as positive controls. None of the renal transplant patients tested positive. PMID:14605164

Glocalized New Age Spirituality: A Mental Map of the New Central Bus Station in Tel Aviv, Deciphered through Its Visual Codes and Based on Ethno-Visual Research

ERIC Educational Resources Information Center

Ben-Peshat, Malka; Sitton, Shoshana

2011-01-01

We present here the findings of an ethno-visual research study involving the creation of a mental map of images, artifacts and practices in Tel Aviv's New Central Bus Station. This huge and complex building, part bus station, part shopping mall, has become a stage for multicultural encounters and interactions among diverse communities of users.…

Telemetric Intracranial Pressure Monitoring with the Raumedic Neurovent P-tel.

PubMed

Antes, Sebastian; Tschan, Christoph A; Heckelmann, Michael; Breuskin, David; Oertel, Joachim

2016-07-01

Devices enabling long-term intracranial pressure monitoring have been demanded for some time. The first solutions using telemetry were proposed in 1967. Since then, many other wireless systems have followed but some technical restrictions have led to unacceptable measurement uncertainties. In 2009, a completely revised telemetric pressure device called Neurovent P-tel was introduced to the market. This report reviews technical aspects, handling, possibilities of data analysis, and the efficiency of the probe in clinical routine. The telemetric device consists of 3 main parts: the passive implant, the active antenna, and the storage monitor. The implant with its parenchymal pressure transducer is inserted via a frontal burr hole. Pressure values can be registered with a frequency of 1 Hz or 5 Hz. Telemetrically gathered data can be viewed on the storage monitor or saved on a computer for detailed analyses. A total of 247 patients with suspected (n = 123) or known (n = 124) intracranial pressure disorders underwent insertion of the telemetric pressure probe. A detailed analysis of the long-term intracranial pressure profile including mean values, maximum and negative peaks, pathologic slow waves, and pulse pressure amplitudes is feasible using the detection rate of 5 Hz. This enables the verification of suspected diagnoses as normal-pressure hydrocephalus, benign intracranial hypertension, shunt malfunction, or shunt overdrainage. Long-term application also facilitates postoperative surveillance and supports valve adjustments of shunt-treated patients. The presented telemetric measurement system is a valuable and effective diagnostic tool in selected cases. Copyright © 2016 Elsevier Inc. All rights reserved.

A qualitative study investigating the use of a mobile phone short message service designed to improve HIV adherence and retention in care in Canada (WelTel BC1).

PubMed

Smillie, Kirsten; Van Borek, Natasha; Abaki, Joshua; Pick, Neora; Maan, Evelyn J; Friesen, Karen; Graham, Rebecca; Levine, Sarah; van der Kop, Mia L; Lester, Richard T; Murray, Melanie

2014-01-01

Patient engagement in care and adherence to medication are critical to achieving the full benefits of antiretroviral therapy (ART) among people with HIV infection. A randomized controlled trial in Kenya, WelTelKenya1, showed that an interactive mobile phone text-messaging intervention can improve adherence and viral load suppression. We conducted a pilot study to adapt the WelTel intervention for HIV-infected clients (n = 25) at an HIV clinic in Vancouver, British Columbia. Between April and June 2012, we recruited five participants from five groups: youth (14-24 years), mature (≥50 years), English as a second language, remote (≥3 hours travel time to clinic), and nonsuppressed (CD4+ T cell count <200 cells/mm(3) and viral load ≥250 copies/mL on two consecutive occasions). Participants described the intervention as a useful way to communicate with health care providers, thus increasing the ability to access services, report side effects, and attend appointments. Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.

Role of the Tel Aviv-Jaffa municipal workers in the treatment of survivors of missile blasts.

PubMed

Silverberg, D S; Sofer, E

1991-01-01

Of the nine missiles that landed on the city of Tel Aviv-Jaffa during the Persian Gulf war, three fell in heavily populated areas. As a result 192 people were sent to hospital and 1,663 (520 families) were left homeless. These were seen and evaluated near the site of the blast by a municipal multidisciplinary team and then sent to one of 15 hotels in and outside the city. There they were treated for acute post-traumatic stress disorder by a municipal health care team (general physicians, nurses, social workers and psychologists) and by psychiatrists from a local sick fund. Many acute and chronic medical problems, including attempted suicide, were also encountered. Community outreach programs aimed at high risk groups and several telephone counselling services were also instituted. We believe that it is crucial to train and provide a multidisciplinary team for handling the survivors of major disasters.

Inventoring Gas in Debris Disks: UV Spectroscopy of Eta Tel

NASA Astrophysics Data System (ADS)

Roberge, Aki

2015-10-01

Debris disks stand between gas-rich protoplanetary disks and mature planetary systems, shedding light on the late stages of planet formation. Their dust component has been extensively studied, yet has provided little information about disk chemical composition. More information can be provided by their gas content, but astonishingly little is known about it. Only two debris disks have measurements of their gas composition, which is shockingly carbon-rich (Beta Pictoris and 49 Ceti). Basic questions remain unanswered. What are the typical gas-to-dust ratios in debris disks? What is the chemical composition of debris gas and its parent material? The answers to these questions have profound implications for terrestrial planet assembly and the origins of planetary atmospheres.Most detections of debris gas to date were achieved with line of sight UV/optical absorption spectroscopy of edge-on disks, using the central star as the background source. This technique is far more sensitive to small amounts of gas than emission line studies. The UV bandpass is particularly important, since strong transitions of numerous atomic and molecular species lie there. We propose extending our intriguing studies of debris gas with STIS UV spectroscopy of a highly promising debris disk system, Eta Tel. This disk is edge-on and contains circumstellar atomic gas (CII). We will measure column densities of the most important gas species, find the relative elemental gas abundances, and determine the gas mass using a powerful gas disk modeling code. We will also divide our observations into two visits, to search for signs of star-grazing exocomets, which are seen in both Beta Pic and 49 Cet.

[The daily life of patients at the Hôtel-Dieu in Lyon in the nineteenth century].

PubMed

Bel, Jean-Christophe; Feireisen, Marie; Fessy, Michel-Henri; Broussolle, Christiane; Neidhardt, Jean-Pierre Hano; Ferrandis, Jean-Jacques

2015-01-01

In 1802 the Hôtel-Dieu in Lyons was incorporated in the so-called Hospices Civils de Lyon. This allowed the expansion and renovation of buildings, as well as the improvement of the conditions of hygiene and comfort of the patients. This hospital was devoted only to the most severely ill or injured adults. 1100 patients were treated by seven doctors, a main surgeon and his deputy, residents and sisters. Broadly speaking the evolution of surgery can be divided into two periods: that of before anesthesia and septic surgery and that of antiseptic and aseptic surgery. We have to mention Gensoul and the resection of the maxillary before anesthesia, Bonnet and Ollier who were devoted to osteo-articular surgery (Ollier's disease), Poncet who built the first aseptic theater, Jaboulay and the resident Carrel who were transplantation's pioneers, Bouveret (paroxysmal tachycardia and Bouveret syndrome), Destot who did the first medical use of X-rays in 1895.

DreamTel; Diabetes risk evaluation and management tele-monitoring study protocol.

PubMed

Tobe, Sheldon W; Wentworth, Joan; Ironstand, Laurie; Hartman, Susan; Hoppe, Jackie; Whiting, Judi; Kennedy, Janice; McAllister, Colin; Kiss, Alex; Perkins, Nancy; Vincent, Lloyd; Pylypchuk, George; Lewanczuk, Richard Z

2009-05-09

The rising prevalence of type 2 diabetes underlines the importance of secondary strategies for the prevention of target organ damage. While access to diabetes education centers and diabetes intensification management has been shown to improve blood glucose control, these services are not available to all that require them, particularly in rural and northern areas. The provision of these services through the Home Care team is an advance that can overcome these barriers. Transfer of blood glucose data electronically from the home to the health care provider may improve diabetes management. The study population will consist of patients with type 2 diabetes with uncontrolled A1c levels living on reserve in the Battlefords region of Saskatchewan, Canada. This pilot study will take place over three phases. In the first phase over three months the impact of the introduction of the Bluetooth enabled glucose monitor will be assessed. In the second phase over three months, the development of guidelines based treatment algorithms for diabetes intensification will be completed. In the third phase lasting 18 months, study subjects will have diabetes intensification according to the algorithms developed. The first phase will determine if the use of the Bluetooth enabled blood glucose devices which can transmit results electronically will lead to changes in A1c levels. It will also determine the feasibility of recruiting subjects to use this technology. The rest of the Diabetes Risk Evaluation and Management Tele-monitoring (DreamTel) study will determine if the delivery of a diabetes intensification management program by the Home Care team supported by the Bluetooth enabled glucose meters leads to improvements in diabetes management. Protocol NCT00325624.

[Hospitalization due to skin diseases at Hôtel-Dieu de France Hospital (Beirut), 1998-2007].

PubMed

Maatouk, Ismaël; Moutran, Roy; Tomb, Roland

2012-01-01

This study aims to determine retrospectively the nature and frequency of dermatological diseases leading to hospitalization at Hôtel-Dieu de France Hospital (HDF) in Beirut, between 1998 and 2007 and to compare them with literature data. For the patients who were hospitalized in dermatology at HDF, we studied: demographics, diagnosis of hospitalization, length of stay, service, mode of financial support, in-hospital evolution, diagnostic tests and treatment. The data were processed by SPSS program. Alopecia areata, psoriatic erythroderma, acute urticaria and vasculitic purpura are the top four diagnoses (85% of hospitalizations). The third of the patients was admitted to same day care. The financial support of the hospitalization is based primarily on public insurance (57.6%). Corticosteroids are the most widely used treatment for patients in dermatology hospital with a frequency of 59.8%. The number of hospitalizations peaked at 44 in 2002 and since then has been declining (11 hospitalizations in 2007). Pathologies encountered in hospital are different from those encountered during consultation. Management of skin diseases on an outpatient basis is often insufficient. In the literature, no profile of skin diseases leading to hospitalization is similar to our study.

Ongoing hepatitis A among men who have sex with men (MSM) linked to outbreaks in Europe in Tel Aviv area, Israel, December 2016 - June 2017.

PubMed

Gozlan, Yael; Bar-Or, Itay; Rakovsky, Aviya; Savion, Michal; Amitai, Ziva; Sheffer, Rivka; Ceder, Noa; Anis, Emilia; Grotto, Itamar; Mendelson, Ella; Mor, Orna

2017-07-20

Between December 2016 and June 2017, 19 Hepatitis A virus (HAV)-positive cases, 17 of which were among men who have sex with men (MSM) were identified in the Tel Aviv area. Seven of the 15 sewage samples collected between January and June 2017 were also HAV-positive. All sequences clustered with two of the three strains identified in the current European HAV outbreak. We demonstrate that despite an efficient vaccination programme, HAV can still be transmitted to an unvaccinated high-risk population. This article is copyright of The Authors, 2017.

Ongoing hepatitis A among men who have sex with men (MSM) linked to outbreaks in Europe in Tel Aviv area, Israel, December 2016 – June 2017

PubMed Central

Gozlan, Yael; Bar-Or, Itay; Rakovsky, Aviya; Savion, Michal; Amitai, Ziva; Sheffer, Rivka; Ceder, Noa; Anis, Emilia; Grotto, Itamar; Mendelson, Ella; Mor, Orna

2017-01-01

Between December 2016 and June 2017, 19 Hepatitis A virus (HAV)-positive cases, 17 of which were among men who have sex with men (MSM) were identified in the Tel Aviv area. Seven of the 15 sewage samples collected between January and June 2017 were also HAV-positive. All sequences clustered with two of the three strains identified in the current European HAV outbreak. We demonstrate that despite an efficient vaccination programme, HAV can still be transmitted to an unvaccinated high-risk population. PMID:28749336

[Sexual behavior characteristics of clients attending the Israel AIDS Task Force anonymous clinic in Tel Aviv].

PubMed

Bar-On, Yaeli; Perry, Zvi H; Nof, Einav; Shiber, Asher; Risenberg, Klaris; Ben Zion, Itzhak

2014-09-01

Until now, research on sexual behavior and HIV in Israel has been carried out mainly on the general population, and focused primarily on defining populations at risk, without adequate consideration given to the reasons bringing these populations to be tested, and their specific sexual behaviors. In Israel, one can choose whether to take an HIV test in confidential centers (giving one's name under medical confidentiality) or in anonymous centers (Israel AIDS Task Force in Tel Aviv and Beer Sheva, Levinsky Clinic in Tel Aviv and Haparsim Clinic in Haifa]. At least 21% of the clients of the anonymous testing centers in Israel belong to a high risk population in contrast to 2.6% in confidential clinics, and so, in this study, we hypothesize that characterization of sexual behavior patterns in anonymous testing centers might enable us to better characterize sexual behavior patterns in high risk populations. In this cross-sectional study, we used questionnaires distributed in the clinics by the Israel AIDS Task Force in order to characterize their clinic's clients. The questionnaires were completed by the Israel AIDS Task Force consultants during the consultation period at which the anonymous test was performed. Data collected included: gender, age, testing history, specific sexual behaviors and reasons for applying for the current test. A total of 926 questionnaires were collected; 29.9% of them were of female patients. The average age was 29.47 years (1±8.66]; 21.3% of the clients were men who have sex with men [MSM]; only 2.3% of the clients belonged to other high risk populations. In all groups, the majority of the patients reported high risk sexual behavior (any sexual contact without a condom) and the average age for the first test was much higher than the average age of first sexual intercourse common in Israel. Women reported more participation in unprotected vaginal intercourse than heterosexual men, and a substantial part of MSM reported performing unprotected

Archaeogeophysical data acquisition and analysis at Tel Burna, Israel: a valuable opportunity for ongoing ground-truth investigation and collaboration (Invited)

NASA Astrophysics Data System (ADS)

Pincus, J. A.

2013-12-01

Tel Burna is a site in the Shephelah breadbasket region of the southern part of Israel. It dates to the Bronze and Iron Age periods, 13th - 7th c. BCE. It has been suggested by scholars to be the Biblical site of Libnah. Libnah is mentioned in the Old Testament as an Israelite desert camp that Joshua encamped and fought against (Joshua 10:29-31; Joshua 12:15). Later it was given as a city to the children of Aaron, it joined the Edomites in a revolt against the King of Judah, and finally during the reign of Hezekiah, Libnah was besieged by Sennacherib (2 Kings 19:8, Isaiah 37:8). Today the tel has a flat-topped shape, has an extensive size, and there are clear casemate wall fortifications dating to the 7th c. BCE surrounding it. Thus far silos, floors, a Late Bronze period cultic area, figurines, and other intriguing artifacts have been unearthed at the site. The site is ideal for a case-study in archaeological geophysics method and interpretation in the region because (1) we are involving the method early in what is expected to be a long timeline of ongoing excavations; (2) it appears we have only a few occupation layers with significant architecture built directly on the bedrock; and (3) there is a relatively unconvoluted geological and pedological context. After conversations with the Director of the Tel Burna Archaeological Project, Itzick Shai, it was decided that out of the three areas actively being excavated a ground penetrating radar (GPR) survey of Area B would be most optimal at this time. The goal was to locate the extent of the archaeological material on the leveled area, while also providing better insight to the cultic area presently being excavated. Area B has proven to have been occupied during the Late Bronze Age IIB (13th c. BCE), as evidenced by the large public building associated with cultic remains, and a complex of walls. Using a 400 MHz antenna, a 30x20 meter grid was surveyed in June 2013. The spacing between each profile was 0.30 meters

DreamTel; Diabetes risk evaluation and management tele-monitoring study protocol

PubMed Central

Tobe, Sheldon W; Wentworth, Joan; Ironstand, Laurie; Hartman, Susan; Hoppe, Jackie; Whiting, Judi; Kennedy, Janice; McAllister, Colin; Kiss, Alex; Perkins, Nancy; Vincent, Lloyd; Pylypchuk, George; Lewanczuk, Richard Z

2009-01-01

Background The rising prevalence of type 2 diabetes underlines the importance of secondary strategies for the prevention of target organ damage. While access to diabetes education centers and diabetes intensification management has been shown to improve blood glucose control, these services are not available to all that require them, particularly in rural and northern areas. The provision of these services through the Home Care team is an advance that can overcome these barriers. Transfer of blood glucose data electronically from the home to the health care provider may improve diabetes management. Methods and design The study population will consist of patients with type 2 diabetes with uncontrolled A1c levels living on reserve in the Battlefords region of Saskatchewan, Canada. This pilot study will take place over three phases. In the first phase over three months the impact of the introduction of the Bluetooth enabled glucose monitor will be assessed. In the second phase over three months, the development of guidelines based treatment algorithms for diabetes intensification will be completed. In the third phase lasting 18 months, study subjects will have diabetes intensification according to the algorithms developed. Discussion The first phase will determine if the use of the Bluetooth enabled blood glucose devices which can transmit results electronically will lead to changes in A1c levels. It will also determine the feasibility of recruiting subjects to use this technology. The rest of the Diabetes Risk Evaluation and Management Tele-monitoring (DreamTel) study will determine if the delivery of a diabetes intensification management program by the Home Care team supported by the Bluetooth enabled glucose meters leads to improvements in diabetes management. Trial Registration Protocol NCT00325624 PMID:19426530

Tuberculosis diagnostic delay and therapy outcomes of non-national migrants in Tel Aviv, 1998-2008.

PubMed

Mor, Z; Kolb, H; Lidji, M; Migliori, Gb; Leventhal, A

2013-03-21

Non-national migrants have limited access to medical therapy. This study compares diagnostic delay and treatment outcomes of non-insured non-national migrants (NINNM) with insured Israeli citizens (IC) in the Tel Aviv tuberculosis (TB) clinic between 1998 and 2008. Patient delay was the time from symptoms onset to doctor's visit, while system delay was measured from doctor visit to anti-TB therapy administration. We randomly sampled 222 NINNM and 265 IC. NINNM were younger than IC, had lower male to female ratio and fewer smoked. They had less drug/alcohol abuse, more cavitations on chest radiography, longer patient and shorter system delay. Mean patient and system delays of all patients were 25 ± 14 and 79 ± 42 days, respectively. In multivariate analysis, being NINNM, asymptomatic or smoking predicted longer patient delay, while being asymptomatic or having additional co-morbidity predicted longer system delay. Treatment success in sputum smear-positive pulmonary TB NINNM was 81% and 95.7% in IC (p=0.01). Treatment success was not associated with patient or system delay. In multivariate analysis, work security and treatment adherence predicted treatment success. NINNM had longer patient delay and worse therapy outcome, while IC had longer system delay. Both delays should be reduced. NINNM should be informed that TB therapy is free and unlinked with deportation.

[The complex travel of cinchona barks between Peru and Québec Hôtel-Dieu, in the middle of the eighteenth century].

PubMed

Simon, Lorène; Lafont, Olivier

2016-03-01

Duplessis sisters, who were religious nuns in Hôtel-Dieu (Quebec hospital), were exchanging letters with a French apothecary from Dieppe in Normandy, named Jacques-Tranquilain Féret. They asked him to send them in Quebec the drugs and medicines their apothecary needed. Amongst these drugs were cinchona barks that came from Callao in Peru by boat, passed Cape Horn and then sailed to Cadiz, the great Spanish port. Then they embarked to Rouen, which was the French port for goods coming from overseas. The goods from Peru had then to be transported on little fishing boats to Dieppe, where Féret received the barks. The apothecary sent these drugs to Quebec by boats sailing either from Rouen or from La Rochelle. So these Peruvian drugs had to cross two times the Ocean before accessing to North America.

Outcomes of a telemonitoring-based program (telEPOC) in frequently hospitalized COPD patients.

PubMed

Esteban, Cristóbal; Moraza, Javier; Iriberri, Milagros; Aguirre, Urko; Goiria, Begoña; Quintana, José M; Aburto, Myriam; Capelastegui, Alberto

2016-01-01

The increasing prevalence of chronic diseases requires changes in health care delivery. In COPD, telemedicine appears to be a useful tool. Our objective was to evaluate the efficacy (in improving health care-resource use and clinical outcomes) of a telemonitoring-based program (telEPOC) in COPD patients with frequent hospitalizations. We conducted a nonrandomized observational study in an intervention cohort of 119 patients (Galdakao-Usansolo Hospital) and a control cohort of 78 patients (Cruces Hospital), followed up for 2 years (ClinicalTrials.gov identifier: NCT02528370). The inclusion criteria were two or more hospital admissions in the previous year or three or more admissions in the previous 2 years. The intervention group received telemonitoring plus education and controls usual care. Most participants were men (13% women), and the sample had a mean age of 70 years, forced expiratory volume in 1 second of 45%, Charlson comorbidity index score of 3.5, and BODE (body mass index, airflow obstruction, dyspnea, and exercise capacity) index score of 4.1. In multivariate analysis, the intervention was independently related to lower rates of hospital admission (odds ratio [OR] 0.38, 95% confidence interval [CI] 0.27-0.54; P <0.0001), emergency department attendance (OR 0.56, 95% CI 0.35-0.92; P <0.02), and 30-day readmission (OR 0.46, 95% CI 0.29-0.74; P <0.001), as well as cumulative length of stay (OR 0.58, 95% CI 0.46-0.73; P <0.0001). The intervention was independently related to changes in several clinical variables during the 2-year follow-up. An intervention including telemonitoring and education was able to reduce the health care-resource use and stabilize the clinical condition of frequently admitted COPD patients.

The impact of the TelEmergency program on rural emergency care: An implementation study.

PubMed

Sterling, Sarah A; Seals, Samantha R; Jones, Alan E; King, Melissa H; Galli, Robert L; Isom, Kristen C; Summers, Richard L; Henderson, Kristi A

2017-07-01

Introduction Timely, appropriate intervention is key to improving outcomes in many emergent conditions. In rural areas, it is particularly challenging to assure quality, timely emergency care. The TelEmergency (TE) program, which utilizes a dual nurse practitioner and emergency medicine-trained, board-certified physician model, has the potential to improve access to quality emergency care in rural areas. The objective of this study was to examine how the implementation of the TE program impacts rural hospital Emergency Department (ED) operations. Methods Methods included a before and after study of the effect of the TE program on participating rural hospitals between January 2007 and December 2008. Data on ED and hospital operations were collected one year prior to and one year following the implementation of TE. Data from participating hospitals were combined and compared for the two time periods. Results Nine hospitals met criteria for inclusion and participated in the study. Total ED volumes did not significantly change with TE implementation, but ED admissions to the same rural hospital significantly increased following TE implementation (6.7% to 8.1%, p-value = 0.02). Likewise, discharge rates from the ED declined post-initiation (87.1% to 80.0%, p-value = 0.003). ED deaths and transfer rates showed no significant change, while the rate of patient discharge against medical advice significantly increased with TE use. Discussion In this analysis, we found a significant increase in the rate of ED admissions to rural hospitals with TE use. These findings may have important implications for the quality of emergency care in rural areas and the sustainability of rural hospitals' EDs.

The impact of an urban park on air pollution and noise levels in the Mediterranean city of Tel-Aviv, Israel.

PubMed

Cohen, Pninit; Potchter, Oded; Schnell, Izhak

2014-12-01

This study examines the influence of urban parks on air quality and noise in the city of Tel-Aviv, Israel, by investigation of an urban park, an urban square and a street canyon. Simultaneous monitoring of several air pollutants and noise levels were conducted. The results showed that urban parks can reduce NOx, CO and PM10 and increase O3 concentrations and that park's mitigation effect is greater at higher NOx and PM10 levels. During extreme events, mean values of 413 ppb NOx and 80 μG/m3 PM10 were measured in the street while mean values of 89 ppb NOx and 24 μG/m3 PM10 were measured in the park. Whereas summer highest O3 values of 84 ppb were measured in the street, 94 ppb were measured in the park. The benefit of the urban park in reducing NOx and PM10 concentrations is more significant than the disadvantage of increased O3 levels. Furthermore, urban parks can reduce noise by ∼5 dB(A). Copyright © 2014 Elsevier Ltd. All rights reserved.

Inositol pyrophosphates mediate the DNA-PK/ATM-p53 cell death pathway by regulating CK2 phosphorylation of Tti1/Tel2

PubMed Central

Rao, Feng; Cha, Jiyoung; Xu, Jing; Xu, Risheng; Vandiver, M. Scott; Tyagi, Richa; Tokhunts, Robert; Koldobskiy, Michael A.; Fu, Chenglai; Barrow, Roxanne; Wu, Mingxuan; Fiedler, Dorothea; Barrow, James C.; Snyder, Solomon H.

2014-01-01

The apoptotic actions of p53 require its phosphorylation by a family of phosphoinositide-3-kinase-related-kinases (PIKKs), which include DNA-PKcs and ATM. These kinases are stabilized by the TTT (Tel2, Tti1, Tti2) co-chaperone family, whose actions are mediated by CK2 phosphorylation. The inositol pyrophosphates, such as 5-diphosphoinositol pentakisphosphate (IP7), are generated by a family of inositol hexakisphosphate kinases (IP6Ks) of which IP6K2 has been implicated in p53-associated cell death. In the present study we report a novel apoptotic signaling cascade linking CK2, TTT, the PIKKs, and p53. We demonstrate that IP7, formed by IP6K2, binds CK2 to enhance its phosphorylation of the TTT complex thereby stabilizing DNA-PKcs and ATM. This process stimulates p53 phosphorylation at serine-15 to activate the cell death program in human cancer cells and in murine B cells. PMID:24657168

TelCoVis: Visual Exploration of Co-occurrence in Urban Human Mobility Based on Telco Data.

PubMed

Wu, Wenchao; Xu, Jiayi; Zeng, Haipeng; Zheng, Yixian; Qu, Huamin; Ni, Bing; Yuan, Mingxuan; Ni, Lionel M

2016-01-01

Understanding co-occurrence in urban human mobility (i.e. people from two regions visit an urban place during the same time span) is of great value in a variety of applications, such as urban planning, business intelligence, social behavior analysis, as well as containing contagious diseases. In recent years, the widespread use of mobile phones brings an unprecedented opportunity to capture large-scale and fine-grained data to study co-occurrence in human mobility. However, due to the lack of systematic and efficient methods, it is challenging for analysts to carry out in-depth analyses and extract valuable information. In this paper, we present TelCoVis, an interactive visual analytics system, which helps analysts leverage their domain knowledge to gain insight into the co-occurrence in urban human mobility based on telco data. Our system integrates visualization techniques with new designs and combines them in a novel way to enhance analysts' perception for a comprehensive exploration. In addition, we propose to study the correlations in co-occurrence (i.e. people from multiple regions visit different places during the same time span) by means of biclustering techniques that allow analysts to better explore coordinated relationships among different regions and identify interesting patterns. The case studies based on a real-world dataset and interviews with domain experts have demonstrated the effectiveness of our system in gaining insights into co-occurrence and facilitating various analytical tasks.

A POTENTIAL ECOFORECAST FOR PROTOZOAL INFECTIONS OF THE EASTERN OYSTER (CRASSOSTREA VIRGINICA)

EPA Science Inventory

McLaughlin, Shawn M. and Stephen J. Jordan. 2003. Potential Ecoforecast for Protozoal Infections of the Eastern Oyster (Crassostrea virginica) in the Upper Chesapeake Bay. In: Ecological Forecasting: New Tools for Coastal Marine Ecosystem Management. Nathalie Valette-Silver and D...

The beginning of metallurgy in the southern Levant: a late 6th millennium CalBC copper awl from Tel Tsaf, Israel.

PubMed

Garfinkel, Yosef; Klimscha, Florian; Shalev, Sariel; Rosenberg, Danny

2014-01-01

The beginning of metallurgy in the ancient Near East attracts much attention. The southern Levant, with the rich assemblage of copper artifacts from the Nahal Mishmar cave and the unique gold rings of the Nahal Qanah cave, is regarded as a main center of early metallurgy during the second half of the 5th millennium CalBC. However, a recently discovered copper awl from a Middle Chalcolithic burial at Tel Tsaf, Jordan Valley, Israel, suggests that cast metal technology was introduced to the region as early as the late 6th millennium CalBC. This paper examines the chemical composition of this item and reviews its context. The results indicate that it was exported from a distant source, probably in the Caucasus, and that the location where it was found is indicative of the social status of the buried individual. This rare finding indicates that metallurgy was first diffused [corrected] to the southern Levant through exchange networks and only centuries later involved local productionThis copper awl, the earliest metal artifact found in the southern Levant, indicates that the elaborate Late Chalcolithic metallurgy developed from a more ancient tradition.

The Beginning of Metallurgy in the Southern Levant: A Late 6th Millennium CalBC Copper Awl from Tel Tsaf, Israel

PubMed Central

Garfinkel, Yosef; Klimscha, Florian; Shalev, Sariel; Rosenberg, Danny

2014-01-01

The beginning of metallurgy in the ancient Near East attracts much attention. The southern Levant, with the rich assemblage of copper artifacts from the Nahal Mishmar cave and the unique gold rings of the Nahal Qanah cave, is regarded as a main center of early metallurgy during the second half of the 5th millennium CalBC. However, a recently discovered copper awl from a Middle Chalcolithic burial at Tel Tsaf, Jordan Valley, Israel, suggests that cast metal technology was introduced to the region as early as the late 6th millennium CalBC. This paper examines the chemical composition of this item and reviews its context. The results indicate that it was exported from a distant source, probably in the Caucasus, and that the location where it was found is indicative of the social status of the buried individual. This rare finding indicates that metallurgy was first defused to the southern Levant through exchange networks and only centuries later involved local production. This copper awl, the earliest metal artifact found in the southern Levant, indicates that the elaborate Late Chalcolithic metallurgy developed from a more ancient tradition. PMID:24671185

How is health-related "deservingness" reckoned? Perspectives from unauthorized im/migrants in Tel Aviv.

PubMed

Willen, Sarah S

2012-03-01

Do unauthorized im/migrants have a right to health? Do they deserve health care, or health protection, or access to the social determinants of good health? Are they party to prevailing social contracts, or does their exclusion from mainstream systems of health promotion, prevention, and care "make sense"? Questions like these, which generate considerable attention in multiple spheres of scholarship, policy, and public debate, revolve around an issue that merits substantially greater consideration among social scientists of health: health-related "deservingness." In addition to putting the issue of health-related deservingness squarely on the map as an object of analysis, this article further argues that we cannot focus solely on those with power, influence, and public voice. Rather, we also must investigate how deservingness is reckoned in relation to--and, furthermore, from the perspectives of-- unauthorized im/migrants and members of other groups commonly constructed in public and policy discourse as undeserving. Additionally, we must consider the complicated relationship between universalizing juridical arguments about formal entitlement to health rights, on one hand, and situationally specific, vernacular moral arguments about deservingness, on the other. The paper analyzes findings from a 29-month mixed-methods study conducted in Tel Aviv, Israel, that approached unauthorized im/migrants as subjects, rather than simply objects, of ethical deliberation. Participants' conceptions of health-related deservingness are investigated using two sources of data: (1) quantitative findings from a self-administered, closed-ended survey conducted with 170 im/migrant patients at an NGO-run Open Clinic (2002-2003), and (2) qualitative findings from the larger ethnographic study of which the survey was part (2000-2010). The study findings both (1) contradict commonly circulating assumptions that unauthorized im/migrants are "freeloaders," and (2) highlight the need for

Park size and disturbance: impact on soil heterogeneity - a case study Tel-Aviv- Jaffa.

NASA Astrophysics Data System (ADS)

Zhevelev, Helena; Sarah, Pariente; Oz, Atar

2015-04-01

Parks and gardens are poly-functional elements of great importance in urban areas, and can be used for optimization of physical and social components in these areas. This study aimed to investigate alteration of soil properties with land usages within urban park and with area size of park. Ten parks differed by size (2 - 50 acres) were chosen, in random, in Tel-Aviv- Jaffa city. Soil was sampled in four microenvironments ((lawn, path, picnic and peripheral area (unorganized area) of each the park)), in three points and three depth (0-2, 5-10 and 10-20 cm). Penetration depth was measured in all point of sampling. For each soil sample electrical conductivity and organic matter content were determined. Averages of penetration depth drastically increased from the most disturbed microenvironments (path and picnic) to the less disturbed ones (lawn and peripheral). The maximal heterogeneity (by variances and percentiles) of penetration depth was found in the peripheral area. In this area, penetration depth increased with increasing park size, i.e., from 2.6 cm to 3.7 cm in the small and large parks, respectively. Averages of organic matter content and electrical conductivity decreased with soil depth in all microenvironments and increased with decreasing disturbance of microenvironments. Maximal heterogeneity for both of these properties was found in the picnic area. Increase of park size was accompanied by increasing of organic matter content in the upper depth in the peripheral area, i.e., from 2.4% in the small parks to 4.5% in the large ones. In all microenvironments the increasing of averages of all studied soil properties was accompanied by increasing heterogeneity, i.e., variances and upper percentiles. The increase in the heterogeneity of the studied soil properties is attributed to improved ecological soil status in the peripheral area, on the one hand, and to the high anthropogenic pressure in the picnic area, on the other. This means that the urban park offers

The Cedar Project WelTel mHealth intervention for HIV prevention in young Indigenous people who use illicit drugs: study protocol for a randomized controlled trial.

PubMed

Jongbloed, Kate; Friedman, Anton J; Pearce, Margo E; Van Der Kop, Mia L; Thomas, Vicky; Demerais, Lou; Pooyak, Sherri; Schechter, Martin T; Lester, Richard T; Spittal, Patricia M

2016-03-09

Despite successes in preventing and treating HIV, Indigenous people in Canada continue to face disproportionately high rates of HIV infection. Programs that support healing from lifetime trauma, support connection to culture, and reduce drug-related harms are critical to preventing HIV among young Indigenous people who use drugs. The Cedar Project WelTel mHealth intervention proposed here is a structured mobile-phone initiative to connect young Indigenous people who use drugs with Cedar Case Managers in a community-based setting. The intervention consists of a package of supports, including a mobile phone and cellular plan, weekly two-way text messaging, and support from Cedar Case Managers. The Cedar Project WelTel mHealth study is a multi-site Zelen pre-randomized trial to measure the effect of a two-way supportive text-message intervention to reduce HIV vulnerability among young Indigenous people who use illicit drugs in two Canadian cities. The trial is nested within the Cedar Project, an ongoing cohort study addressing HIV and hepatitis C vulnerability among young Indigenous people who use drugs in Vancouver and Prince George, British Columbia. The Cedar Project Partnership, an independent body of Indigenous Elders, leaders, and health/social service experts, governs all aspects of the study. Two hundred participants will be followed over a 16-month period, with HIV propensity score at 6 months as the primary outcome. Secondary outcomes include HIV propensity at 1 year, HIV risk, resilience, psychological distress, access to drug-related services, and connection to culture measured at 6 months and 1 year. Primary analysis is by intention to treat. Culturally safe interventions that address barriers to HIV prevention while supporting the strength of young Indigenous people who use drugs are urgently needed. Despite presenting a tremendous opportunity to connect young, highly transient Indigenous people who use drugs to prevention services, supportive two-way m

Topical Treatment of Cutaneous Leishmaniasis W/WR279396 Phase II Study. Addendum

DTIC Science & Technology

2006-07-01

France) g. Tape so seal plates h. Sterile flat-bottom 96-well plates i. Inverted microscope with trail (France) j . Cryomarkers 2. Check list 2...Subinvestigators: Nathalie Messaoud Amor Zaâtour Abdelkarim El Fahem Nabil Haj Hmida OBJECTIVE To collaborate with the monitoring visit SUNDAY 19/02

A Good Story: A Commentary on "Contextualizing the Intermediate Financial Accounting Courses in the Global Financial Crisis"

ERIC Educational Resources Information Center

Phillips, Fred; Johnstone, Nathalie; Mackintosh, Brandy

2011-01-01

Bloom and Webinger (2011) present an intuitively agreeable proposition: embedding topics within an engaging and meaningful context can promote many desirable learning behaviours and outcomes. As instructors, Fred Phillips, Nathalie Johnstone, and Brandy Mackintosh have seen this play out many times in their classrooms. Thus, in a sense, they were…

Medical condition and care of undocumented migrants in ambulatory clinics in Tel Aviv, Israel: assessing unmet needs.

PubMed

Mor, Zohar; Raveh, Yuval; Lurie, Ido; Leventhal, Alex; Gamzu, Roni; Davidovitch, Nadav; Benari, Orel; Grotto, Itamar

2017-07-14

Approximately 150,000 undocumented migrants (UM) who are medically uninsured reside in Israel, including ~50,000 originating from the horn of Africa (MHA). Free medical-care is provided by two walk-in clinics in Tel-Aviv. This study aims to compare the medical complaints of UM from different origins, define their community health needs and assess gaps between medical needs and available services. This cross-sectional study included a random sample of 610 UM aged 18-64 years, who were treated in these community clinics between 2008 and 2011. The study compared UM who had complex medical conditions which necessitated referral to more equipped medical settings with UM having mild/simple medical conditions, who were treated at the clinics. MHA were younger, unemployed and more commonly males compared with UM originating from other countries. MHA also had longer referral-delays and visited the clinics less frequently. UM with complex medical conditions were more commonly females, had chronic diseases and demonstrated longer referral-delays than those who had mild/simple medical conditions. The latter more commonly presented with complained of respiratory, muscular and skeletal discomfort. In multivariate analysis, the variables which predicted complex medical conditions included female gender, chronic illnes and self-referral to the clinics. The ambulatory clinics were capable of responding to mild/simple medical conditions. Yet, the health needs of women and migrants suffering from complex medical conditions and chronic diseases necessitated referrals to secondary/tertiary medical settings, while jeopardizing the continuity of care. The health gaps can be addressed by a more holistic social approach, which includes integration of UM in universal health insurance.

A tap water turbidity crisis in Tel Aviv, Israel, due to technical failure: toxicological and risk management issues.

PubMed

Winston, Gary; Lerman, Shlomo; Goldberger, Shalom; Collins, Malcolm; Leventhal, Alex

2003-06-01

Herein, we report on the actual events linked to an ammonia spillage into the main waterline of the Tel-Aviv metropolitan area and its surrounding municipalities. Based upon a large magnitude increase of unknown origin in the turbidity and ammonia levels of the main drinking water supply, area residents were warned of possible serious contamination and advised to refrain from drinking tap water until further notice. Turbidity was later linked only to CaCO3, which was precipitated from the water due to the rise in pH caused by the excessive ammonia levels. The source of the ammonia (a malfunction of the measurement buoy in the ammonia tank) was not identified until several days after the warning was issued. The toxicological implications of the turbidity and ammonia elevations are considered and reconciled with the management strategies that followed. Of consequence to the management of this crisis was the approach of Ministry of Health officials to regard the ammonia, from the onset, as an indicator of several possible sources of origin rather than as a contaminant. Decision-making policies were hampered by ineffective communication between the national water supplier and government health officials. An outcome of this crisis was a heightened awareness of the potential of a water crisis occurring during peace time and not only in association with terrorist activities, to which Israeli citizens are highly sensitized. Finally, the present paper may serve to guide municipal environmental and health officials more appropriately in the event of similar drinking water crises in Israel or elsewhere.

Proceedings from an International Conference on Computers and Philosophy, i-C&P 2006 held 3-5 May 2006 in Laval, France

DTIC Science & Technology

2008-10-20

embedded intelligence and cultural adaptations to the onslaught of robots in society. This volume constitutes a key contribution to the body of... Robotics , CNRS/Toulouse University, France Nathalie COLINEAU, Language & Multi-modality, CSIRO, Australia Roberto CORDESCHI, Computation & Communication...Intelligence, SONY CSL ­ Paris Nik KASABOV, Computer and Information Sciences, Auckland University, New Zealand Oussama KHATIB, Robotics & Artificial

Poster Day Showcases Student Work | Poster

Cancer.gov

By Nathalie Walker, Guest Writer, and Carolynne Keenan, Contributing Writer On July 31, NCI at Frederick hosted Student Poster Day, an annual event in which student interns can showcase the work they do in their various positions in NCI at Frederick labs and offices. Participating students are interns in the Student Internship Program, a program designed for undergraduate and

Bruyères-le-Châtel Neutron Evaluations of Actinides with the TALYS Code: The Fission Channel

DOE Office of Scientific and Technical Information (OSTI.GOV)

Romain, P., E-mail: pascal.romain@cea.fr; Morillon, B.; Duarte, H.

For several years, various neutron evaluations of plutonium and uranium isotopes have been performed at Bruyères-le-Châtel (BRC), from 1 keV up to 30 MeV. Since only nuclear reaction models have been used to produce these evaluations, our approach was named the “Full Model” approach. Total, shape elastic and direct inelastic cross sections were obtained from the coupled channels model using a dispersive optical potential developed for actinides, with a large enough coupling scheme including the lowest octupolar band. All other cross sections were calculated using the Hauser-Feshbach theory (TALYS code) with a pre-equilibrium component above 8–10 MeV. In this paper,more » we focus our attention on the fission channel. More precisely, we will present the BRC contribution to fission modeling and the philosophy adopted in our “Full Model” approach. Performing evaluations with the “Full Model” approach implies the optimization of a large number of model parameters. With increasing neutron incident energy, many residual nuclei produced by nucleon emission also lead to fission. All available experimental data assigned to various fission mechanisms of the same nucleus were used to determine fission barrier parameters. For uranium isotopes, triple-humped fission barriers were required in order to reproduce accurately variations of the experimental fission cross sections. Our BRC fission modeling has shown that the effects of the class II or class III states located in the wells of the fission barrier sometimes provide an anti-resonant transmission rather than a resonant one. Consistent evaluations were produced for a large series of U and Pu isotopes. Resulting files were tested against integral data.« less

Structure and vascular tissue expression of duplicated TERMINAL EAR1-like paralogues in poplar.

PubMed

Charon, Céline; Vivancos, Julien; Mazubert, Christelle; Paquet, Nicolas; Pilate, Gilles; Dron, Michel

2010-02-01

TERMINAL EAR1-like (TEL) genes encode putative RNA-binding proteins only found in land plants. Previous studies suggested that they may regulate tissue and organ initiation in Poaceae. Two TEL genes were identified in both Populus trichocarpa and the hybrid aspen Populus tremula x P. alba, named, respectively, PoptrTEL1-2 and PtaTEL1-2. The analysis of the organisation around the PoptrTEL genes in the P. trichocarpa genome and the estimation of the synonymous substitution rate for PtaTEL1-2 genes indicate that the paralogous link between these two Populus TEL genes probably results from the Salicoid large-scale gene-duplication event. Phylogenetic analyses confirmed their orthology link with the other TEL genes. The expression pattern of both PtaTEL genes appeared to be restricted to the mother cells of the plant body: leaf founder cells, leaf primordia, axillary buds and root differentiating tissues, as well as to mother cells of vascular tissues. Most interestingly, PtaTEL1-2 transcripts were found in differentiating cells of secondary xylem and phloem, but probably not in the cambium itself. Taken together, these results indicate specific expression of the TEL genes in differentiating cells controlling tissue and organ development in Populus (and other Angiosperm species).

The budding yeast Rad9 checkpoint protein is subjected to Mec1/Tel1-dependent hyperphosphorylation and interacts with Rad53 after DNA damage.

PubMed

Vialard, J E; Gilbert, C S; Green, C M; Lowndes, N F

1998-10-01

The Saccharomyces cerevisiae RAD9 checkpoint gene is required for transient cell-cycle arrests and transcriptional induction of DNA repair genes in response to DNA damage. Polyclonal antibodies raised against the Rad9 protein recognized several polypeptides in asynchronous cultures, and in cells arrested in S or G2/M phases while a single form was observed in G1-arrested cells. Treatment with various DNA damaging agents, i.e. UV, ionizing radiation or methyl methane sulfonate, resulted in the appearance of hypermodified forms of the protein. All modifications detected during a normal cell cycle and after DNA damage were sensitive to phosphatase treatment, indicating that they resulted from phosphorylation. Damage-induced hyperphosphorylation of Rad9 correlated with checkpoint functions (cell-cycle arrest and transcriptional induction) and was cell-cycle stage- and progression-independent. In asynchronous cultures, Rad9 hyperphosphorylation was dependent on MEC1 and TEL1, homologues of the ATR and ATM genes. In G1-arrested cells, damage-dependent hyperphosphorylation required functional MEC1 in addition to RAD17, RAD24, MEC3 and DDC1, demonstrating cell-cycle stage specificity of the checkpoint genes in this response to DNA damage. Analysis of checkpoint protein interactions after DNA damage revealed that Rad9 physically associates with Rad53.

Spatial variability of soil and vegetation characteristics in an urban park in Tel-Aviv

NASA Astrophysics Data System (ADS)

Sarah, Pariente; Zhevelev, Helena M.; Oz, Atar

2010-05-01

Mosaic-like spatial patterns, consisting of divers soil microenvironments, characterize the landscapes of many urban parks. These microenvironments may differ in their pedological, hydrological and floral characteristics, and they play important roles in urban ecogeomorphic system functioning. In and around a park covering 50 ha in Tel Aviv, Israel, soil properties and herbaceous vegetation were measured in eight types of microenvironments. Six microenvironments were within the park: area under Ceratonia siliqua (Cs-U), area under Ficus sycomorus (Fi-U), a rest area under F. sycomorus (Re-U), an open area with bare soil (Oa-S), an open area with biological crusts (Oa-C), and an open area with herbaceous vegetation (Oa-V). Outside the park were two control microenvironments, located, respectively, on a flat area (Co-P) and an inclined open area (Co-S). The soil was sampled from two depths (0-2 and 5-10 cm), during the peak of the growing season (March). For each soil sample, moisture content, organic matter content, CaCO3 content, texture, pH, electrical conductivity, and soluble ions contents were determined in 1:1 water extraction. In addition, prior to the soil sampling, vegetation cover, number of species, and species diversity of herbaceous vegetation were measured. The barbecue fires and visitors in each of the microenvironments were counted. Whereas the soil organic matter and vegetation in Fi-U differed from those in the control(Co-P, Co-S), those in Oa-V were similar to those in the control. Fi-U was characterized by higher values of soil moisture, organic matter, penetration depth, and vegetation cover than Cs-U. Open microenvironments within the park (Oa-S, Oa-C, Oa-V) showed lower values of soil penetration than the control microenvironments. In Oa-V unique types of plants such as Capsella bursa-pastoris and Anagallis arvensis, which did not appear in the control microenvironments, were found. This was true also for Fi-U, in which species like Oxalis pes

(Updated) Nanotechnology: Understanding the Tiny Particles That May Save a Life | Poster

Cancer.gov

By Nathalie Walker, Guest Writer Could nanotechnology—the study of tiny matter ranging in size from 1 to 200 nanometers—be the future of cancer treatment? Although it is a relatively new field in cancer research, nanotechnology is not new to everyday life. Have you ever thought about the tennis ball you’ve thrown with your dog at the park and wondered what it is made of?

Reflections on My Werner H. Kirsten Student Internship | Poster

Cancer.gov

By Nathalie Walker, Guest Writer Editor’s note: This article represents one student’s perspective on her experiences as a Werner H. Kirsten student intern. Failure isn’t just a possibility, it is a certainty; yet failure is what leads you to success. Above all else, that is what I will retain from my experience in the Werner H. Kirsten Student Intern Program (WHK SIP).

78 FR 21497 - Publication of General Licenses Related to the Burma Sanctions Program

Federal Register 2010, 2011, 2012, 2013, 2014

2013-04-10

... General License No. 19. FOR FURTHER INFORMATION CONTACT: Assistant Director for Sanctions Compliance & Evaluation, tel.: 202-622-2490, Assistant Director for Licensing, tel.: 202-622-2480, Assistant Director for Regulatory Affairs, tel.: 202-622-4855, Assistant Director for Policy, tel.: 202- 622-2746, Office of Foreign...

Linking Emotional Intelligence to Achieve Technology Enhanced Learning in Higher Education

ERIC Educational Resources Information Center

Kruger, Janette; Blignaut, A. Seugnet

2013-01-01

Higher education institutions (HEIs) increasingly use technology-enhanced learning (TEL) environments (e.g. blended learning and e-learning) to improve student throughput and retention rates. As the demand for TEL courses increases, expectations rise for faculty to meet the challenge of using TEL effectively. The promises that TEL holds have not…

Writing My Way to My Future | Poster

Cancer.gov

By Nathalie Walker, Guest Writer Editor’s note: This article is the second in a series describing one student’s perspective on her experiences as a Werner H. Kirsten student intern. “The future depends on what you do today.” Those wise words were spoken by Mahatma Gandhi. Before I started my Werner H. Kirsten (WHK) student internship, I did not know what I know now. I only

The significance of visitors' pressure for soil status in an urban park in Tel-Aviv

NASA Astrophysics Data System (ADS)

Zhevelev, Helena; Sarah, Pariente; Oz, Atar

2010-05-01

A park is one of the most important elements of sustainable development and optimization of the urban environment. The equilibrium within the complex of natural and anthropogenic factors defines the status of a park's ecosystem. The seasonal dynamics and spatial variations of soil properties in areas under differing levels of visitors' pressure were studied in a park in Tel-Aviv. Soil was sampled twice a year, in wet (March) and dry (July) seasons, from three types of areas, subjected to differing levels of visitors' pressure: high, low and none (control). In each type of area samples were taken from two depths (0-2 cm and 5-10 cm), at 14-39 points. In total, 268 soil samples were taken. Before the soil sampling, penetration depth was determined at each point. In addition, the numbers of barbecue fires in each of the three areas were counted. Gravimetric soil moisture, organic matter, pH, electrical conductivity, and soluble ions were measured in 1:1 water extraction. Penetration depth and electrical conductivity, and organic matter, sodium, potassium and chlorite contents differed under differing levels of visitors' pressure, whereas soil moisture, pH and calcium content exhibited only minor differences. Soil moisture, electrical conductivity, and magnesium and chlorite contents exhibited strong seasonal changes, whereas the organic matter, potassium and pH levels were unaffected by seasonal dynamics. Calcium, organic matter, magnesium and chlorite contents, and electrical conductivity were significantly affected by the depth of soil sampling, whereas pH was not so affected. The seasonal changes in soil properties in the area subjected to high visitors' pressure were higher than in the one under low visitors' pressure. In most cases, visitors' pressure led to increases in variance and coefficient of variation. Different soil properties were differently affected by visitors' pressure, seasonal dynamics and soil depth. The surface of the soil was more sensitive to

Implementation of CycleTel Family Advice: an SMS-based service to provide family planning and fertility awareness information in India.

PubMed

Ashcroft, Nicki; Shelus, Victoria; Garg, Himanshu; McLarnon-Silk, Courtney; Jennings, Victoria H

2017-01-01

CycleTel Family Advice (CFA), an SMS-based service designed to improve knowledge of fertility and family planning (FP), was delivered to over 100,000 people in India from April to August 2015. The goal of CFA was to increase knowledge on a range of reproductive health topics, e.g., the menstrual cycle, fertility, and FP, and to increase positive perceptions and use of FP. This paper focuses on the best practices and operational challenges for providing an SMS service based on the implementation experience of CFA. The implementation process for CFA was well documented, specifically program design, commercial partnerships, formative research, design of messages, and recruitment of users. The impact of CFA on knowledge, attitudes, and behaviors was assessed through phone surveys before and after message delivery. Programmatic data and phone surveys resulted in several operational findings, particularly in the areas of user behavior, partnership management, and mHealth research. While there were improvements in knowledge, there were not significant changes in FP use and couple communication. The intervention yielded insights into designing an mHealth intervention as well as the opportunities and challenges of implementing a stand-alone SMS-based service with a broad audience. Lessons learned were that (I) SMS-based interventions, without other supporting systems, may not lead to high user engagement or behavior change; (II) partnerships with private sector technical platforms can help overcome the difficult problem of marketing and outreach, but they bring limitations to user interface and dependencies on a commercial structure; (III) collecting demographic data required to provide tailored content may be a barrier to user acquisition; and (IV) while phone surveys are useful for evaluation of mHealth interventions, reaching users is challenging and response rates are low.

Med-E-Tel

DTIC Science & Technology

2006-04-01

the countries and regions represented by the Project; – The prevalence Chronic Obstructive Pulmonary Diseases (COPD), Congestive Heart Failure, (CHF...teleconsultations were lead per year); • tuberculosis subnetwork ( regional center and 4 remote station in rural areas, teleconsultations were lead...Erik Garcia Mexico Cube-Sat solution proposal for the lack of a permanent satellite channel for telemedicine purposes in the American Region Lilia

Telephone-based continuing care counseling in substance abuse treatment: economic analysis of a randomized trial

PubMed Central

Daley, Marilyn C.; Neuman, Matthew J.; Blaakman, Aaron P.; McKay, James R.

2016-01-01

Purpose To investigate whether telephone-based continuing care (TEL) is a promising alternative to traditional face-to-face counseling for clients in treatment for substance abuse. Methods Patients with alcohol and/or cocaine dependence who had completed a 4-week intensive outpatient program were randomly assigned through urn randomization into one of three 12-week interventions: standard continuing care (STD), in-person relapse prevention (RP), or telephone-based continuing care (TEL). This study performed cost, cost-effectiveness, and cost-benefit analyses of TEL and RP compared to STD, using results from the randomized clinical trial with two years of follow up (359 participants). In addition, the study examined the potential moderating effect of baseline patient costs on economic outcomes. Results The study found that TEL was less expensive per client from the societal perspective ($569) than STD ($870) or RP ($1,684). TEL also was also significantly more effective, with an abstinence rate of 57.1% compared to 46.7% for STD (p<0.05). Thus TEL dominated STD, with a highly favorable negative incremental cost-effectiveness ratio (−$1,400 per abstinent year). TEL also proved favorable under a benefit-cost perspective. Conclusions TEL proved to be a cost-effective and cost-beneficial contributor to long-term recovery over two years. Because TEL dominated STD care interventions, wider adoption should be considered. PMID:26718395

Telephone-based continuing care counseling in substance abuse treatment: Economic analysis of a randomized trial.

PubMed

Shepard, Donald S; Daley, Marilyn C; Neuman, Matthew J; Blaakman, Aaron P; McKay, James R

2016-02-01

To investigate whether telephone-based continuing care (TEL) is a promising alternative to traditional face-to-face counseling for clients in treatment for substance abuse. Patients with alcohol and/or cocaine dependence who had completed a 4-week intensive outpatient program were randomly assigned through urn randomization into one of three 12-week interventions: standard continuing care (STD), in-person relapse prevention (RP), or telephone-based continuing care (TEL). This study performed cost, cost-effectiveness, and cost-benefit analyses of TEL and RP compared to STD, using results from the randomized clinical trial with two years of follow up (359 participants). In addition, the study examined the potential moderating effect of baseline patient costs on economic outcomes. The study found that TEL was less expensive per client from the societal perspective ($569) than STD ($870) or RP ($1684). TEL also was also significantly more effective, with an abstinence rate of 57.1% compared to 46.7% for STD (p<0.05). Thus TEL dominated STD, with a highly favorable negative incremental cost-effectiveness ratio (-$1400 per abstinent year). TEL also proved favorable under a benefit-cost perspective. TEL proved to be a cost-effective and cost-beneficial contributor to long-term recovery over two years. Because TEL dominated STD care interventions, wider adoption should be considered. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

The contribution of cat owners' attitudes and behaviours to the free-roaming cat overpopulation in Tel Aviv, Israel.

PubMed

Finkler, Hilit; Terkel, Joseph

2012-04-01

The attitudes and behaviours of cat owners in regard to treatment of cats may have a cumulative effect on the food availability, reproduction, density and welfare of the free-roaming cat population and thus also on the extent of cat overpopulation. Understanding this is thus a vital step in the a priori planning of cat management programs on any scale, as well as in developing public education programs on this issue. Although recent years have seen an accumulation of knowledge in regard to cat owners' attitudes and behaviours, the findings vary among countries and locations and in Israel this has never been investigated systematically. Using a questionnaire provided to cat owners in veterinary clinics, this study aimed at identifying those attitudes and behaviours that may be contributing to cat overpopulation in Tel Aviv, Israel, and at exploring the socio-economic factors that influence this problem. The findings show that the influential factors can be predicted from the cat owners' socio-economic status, mainly education and income, as well as gender and age. A consistency in those cat owner behaviours that contribute to cat overpopulation was also uncovered, revealing a sub-population of individuals who persist in the undesirable behaviours. Finally, a strong relationship between attitude and consequent behaviour was demonstrated, indicating the importance of education and targeted publicity as a means to influence attitudes and thereby change behaviours in this respect. We propose several measures by which to reduce the current extent of cat owners' contribution to the cat overpopulation: discouraging unwanted owner behaviours such as abandonment of their cats and allowing them to breed; promoting awareness of the neutering option among cat caretakers; and increasing pre-adoption neutering rates in shelters. Regional and national laws promoting responsible pet ownership need to be enacted. By improving the current level of knowledge and awareness among cat

Corrosion Behavior of Weathering Steel Under Thin Electrolyte Layer at Different Relative Humidity

NASA Astrophysics Data System (ADS)

Xia, Yan; Liu, Pan; Zhang, Jianqing; Cao, Fahe

2018-01-01

The corrosion behavior of weathering steel under thin electrolyte layer (TEL) at different relative humidity (RH) was investigated by cathodic polarization, electrochemical impedance spectroscopy, electrochemical noise, SEM/EDS, XRD and Raman spectroscopy. The results indicate that during the initial stage, the corrosion rate increases as the RH decreases when the initial thickness of TEL is above 100 μm. During the middle and final corrosion stages, the corrosion behavior of weathering steel is influenced by RH, the initial thickness of TEL and corrosion product. The TEL corrosion is divided into three types, and a weathering steel corrosion model under TEL and bulk solution is also proposed.

(Updated) Nanotechnology: Understanding the Tiny Particles That May Save a Life | Poster

Cancer.gov

By Nathalie Walker, Guest Writer Could nanotechnology—the study of tiny matter ranging in size from 1 to 200 nanometers—be the future of cancer treatment? Although it is a relatively new field in cancer research, nanotechnology is not new to everyday life. Have you ever thought about the tennis ball you’ve thrown with your dog at the park and wondered what it is made of? Nanotechnology is used to make the tennis ball stronger.

Telmisartan prevents hepatic fibrosis and enzyme-altered lesions in liver cirrhosis rat induced by a choline-deficient L-amino acid-defined diet

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jin Haiyan; Department of Gastroenterology and Hepatology, Yanbian University Hospital, Yanji, Jilin; Yamamoto, Naoki

2007-12-28

Rennin-angiotensin system is involved in liver fibrogenesis through activating hepatic stellate cells (HSCs). Telmisartan (Tel) is an angiotensin II type 1 receptor antagonist, could function as a selective peroxisome proliferator-activated receptor {gamma} activator. Here we studied the effect of Tel on liver fibrosis, pre-neoplastic lesions in vivo and primary HSCs in vitro. In vivo study, we used the choline-deficient L-amino acid-defined (CDAA)-diet induced rat NASH model. The rats were fed the CDAA diet for 8 weeks to induce liver fibrosis and pre-neoplastic lesions, and then co-administrated with Tel for another 10 weeks. Tel prevented liver fibrogenesis and pre-neoplastic lesions bymore » down-regulating TGF{beta}1 and TIMP-1, 2 and increasing MMP-13 expression. Tel inhibited HSCs activation and proliferation. These results suggested that Tel could be a promising drug for NASH related liver fibrosis.« less

Telmisartan prevents hepatic fibrosis and enzyme-altered lesions in liver cirrhosis rat induced by a choline-deficient L-amino acid-defined diet.

PubMed

Jin, Haiyan; Yamamoto, Naoki; Uchida, Koichi; Terai, Shuji; Sakaida, Isao

2007-12-28

Rennin-angiotensin system is involved in liver fibrogenesis through activating hepatic stellate cells (HSCs). Telmisartan (Tel) is an angiotensin II type 1 receptor antagonist, could function as a selective peroxisome proliferator-activated receptor gamma activator. Here we studied the effect of Tel on liver fibrosis, pre-neoplastic lesions in vivo and primary HSCs in vitro. In vivo study, we used the choline-deficient L-amino acid-defined (CDAA)-diet induced rat NASH model. The rats were fed the CDAA diet for 8 weeks to induce liver fibrosis and pre-neoplastic lesions, and then co-administrated with Tel for another 10 weeks. Tel prevented liver fibrogenesis and pre-neoplastic lesions by down-regulating TGFbeta1 and TIMP-1, 2 and increasing MMP-13 expression. Tel inhibited HSCs activation and proliferation. These results suggested that Tel could be a promising drug for NASH related liver fibrosis.

Reversible conversion of immortal human cells from telomerase-positive to telomerase-negative cells.

PubMed

Kumakura, Shin-ichi; Tsutsui, Takeo W; Yagisawa, Junko; Barrett, J Carl; Tsutsui, Takeki

2005-04-01

Immortal cell lines and tumors maintain their telomeres via the telomerase pathway or via a telomerase-independent pathway, referred to as alternative lengthening of telomeres (ALT). Here, we show the reversible conversion of the human papillomavirus type 16 E6-induced immortal human fibroblasts E6 Cl 6 from telomerase-positive (Tel(+)) to telomerase-negative (Tel(-)) cells. Tel(+) cells converted spontaneously to Tel(-) cells that reverted to Tel(+) cells following treatment with trichostatin A (TSA) and/or 5-aza-2'-deoxycytidine (5-AZC), which induced the reversion from complete to partial methylation of the CpG islands of the human telomerase reverse transcriptase (hTERT) promoter in Tel(-) E6 Cl 6 cells. Tel(-) E6 Cl 6 cells lacked the phenotypes characteristic of ALT cell lines such as very long and heterogenous telomeres and ALT-associated promyelocytic leukemia nuclear bodies (APB) but grew for >240 population doublings (PD) after they became telomerase negative. The ratios of histone H3 (H3) lysine (K) 9 methylation to each of H3-K4 methylation, H3-K9 acetylation, and H3-K14 acetylation of the chromatin containing the hTERT promoter in Tel(-) E6 Cl 6 cells and ALT cell lines were greater than those in Tel(+) cells and decreased following treatment with TSA and/or 5-AZC, inversely corresponding to telomerase activity. Our findings suggest the possibility that human tumors may be able to reversibly interconvert their telomere maintenance phenotypes by chromatin structure-mediated regulation of hTERT expression.

A telephonic intervention for promoting occupational re-integration in work-disabled individuals with musculoskeletal pain.

PubMed

Sullivan, Michael J L; Simon, Gregory

2012-06-01

The purpose of the present research was to examine the feasibility of a telephonic occupational rehabilitation program. A sample of 23 individuals with chronic musculoskeletal pain was enrolled in the telephonic version of the Progressive Goal Attainment Program (PGAP-Tel). The PGAP-Tel is a risk-targeted intervention designed to reduce pain-related disability consequent to musculoskeletal injury. Treatment outcomes of PGAP-Tel were compared to a group of individuals with chronic musculoskeletal pain, who participated in the face-to-face format of the PGAP. Results showed that PGAP-Tel was acceptable to the majority of participants (76%) to whom it was offered. There were indications that engagement and adherence issues were more problematic in PGAP-Tel than in the face-to-face intervention. Both groups showed comparable reductions in pain, depression, fear of symptom exacerbation, and self-reported disability. Participants in the face-to-face intervention showed greater reduction in catastrophic thinking than participants in PGAP-Tel. Finally, 26% of participants in PGAP-Tel had resumed some form of employment at treatment termination compared to 56% of the participants in the face-to-face intervention. Given the low cost of the PGAP-Tel intervention and the accessibility advantages of a telephonic delivery, this type of intervention might be an important resource for targeting occupational disability in rural or remote communities when face-to-face services are not available.

Involvement of intestinal permeability in the oral absorption of clarithromycin and telithromycin.

PubMed

Togami, Kohei; Hayashi, Yoshiaki; Chono, Sumio; Morimoto, Kazuhiro

2014-09-01

The involvement of intestinal permeability in the oral absorption of clarithromycin (CAM), a macrolide antibiotic, and telithromycin (TEL), a ketolide antibiotic, in the presence of efflux transporters was examined. In order independently to examine the intestinal and hepatic availability, CAM and TEL (10 mg/kg) were administered orally, intraportally and intravenously to rats. The intestinal and hepatic availability was calculated from the area under the plasma concentration-time curve (AUC) after administration of CAM and TEL via different routes. The intestinal availabilities of CAM and TEL were lower than their hepatic availabilities. The intestinal availability after oral administration of CAM and TEL increased by 1.3- and 1.6-fold, respectively, after concomitant oral administration of verapamil as a P-glycoprotein (P-gp) inhibitor. Further, an in vitro transport experiment was performed using Caco-2 cell monolayers as a model of intestinal epithelial cells. The apical-to-basolateral transport of CAM and TEL through the Caco-2 cell monolayers was lower than their basolateral-to-apical transport. Verapamil and bromosulfophthalein as a multidrug resistance-associated proteins (MRPs) inhibitor significantly increased the apical-to-basolateral transport of CAM and TEL. Thus, the results suggest that oral absorption of CAM and TEL is dependent on intestinal permeability that may be limited by P-gp and MRPs on the intestinal epithelial cells. Copyright © 2014 John Wiley & Sons, Ltd.

Expanding the scope of anatomical sciences: the case of "Human evolution: The fossil evidence" course at the Sackler School of Medicine, Tel-Aviv University.

PubMed

Notzer, Netta; Abramovitz, Ruth

2012-01-01

The Anatomy Department at Tel-Aviv University Medical School offers its students an elective course of 26 didactic hours on human evolution. The course is open to students from all faculties, who must fulfill all academic requirements, without a prerequisite of a background in anatomy. Approximately 120 students attend annually, a third of them are nonmedical students who major in philosophy, archeology, and sociology. This article discusses the course's contributions to students' understanding of a scientific concept that a scientific theory can be contradicted by new evidence, because facts govern science. Also, research methods of applying scientific principles establish the understanding of the human body, which evidently contributes to health and medicine. In the classes, the students are divided into mini-groups of 2-3 students, while the lecturer moves among students to examine fossils. In addition, analogies, open-discussions, and explanations accompany the tangible experiences. The lecturer of the course is an experienced anthropologist-anatomist researcher. He is a role-model and a mentor, sharing with the students his belief that a scientist should be persistent in his research to overcome difficult circumstances. Students, regardless of their backgrounds, express high appreciation of the course in their feedback questionnaires. The message conveyed by this course is that not only knowledge counts but also its integration with scientific principles. This course teaches us that science can bring students from different areas to study together and share ideas. In conclusion, this is a unique course in the eyes of the faculty and students alike. Copyright © 2012 American Association of Anatomists.

In vitro corrosion of pure magnesium and AZ91 alloy—the influence of thin electrolyte layer thickness

PubMed Central

Zeng, Rong-Chang; Qi, Wei-Chen; Zhang, Fen; Li, Shuo-Qi

2016-01-01

In vivo degradation predication faces a huge challenge via in vitro corrosion test due to the difficulty for mimicking the complicated microenvironment with various influencing factors. A thin electrolyte layer (TEL) cell for in vitro corrosion of pure magnesium and AZ91 alloy was presented to stimulate the in vivo corrosion in the micro-environment built by the interface of the implant and its neighboring tissue. The results demonstrated that the in vivo corrosion of pure Mg and the AZ91 alloy was suppressed under TEL condition. The AZ91 alloy was more sensitive than pure Mg to the inhibition of corrosion under a TEL thickness of less than 200 µm. The TEL thickness limited the distribution of current, and thus localized corrosion was more preferred to occur under TEL condition than in bulk solution. The TEL cell might be an appropriate approach to simulating the in vivo degradation of magnesium and its alloys. PMID:26816655

Special Course on Unsteady Aerodynamics.

DTIC Science & Technology

1980-06-01

Helicopters Ltd Yeovil, Somerset Tel: 935-5222 (434) BOHN Germany Engineer Dieter Kraftwerk Union AG Wiesenstrasse 25 433 Mfiheim Tel: 0208/456.1 BORLAND...Royce Ltd. P.O.B.31 Derby Tel: 42424- Ext.1594 JUDITH Germany Dipl.-Engineer Hans Kraftwerk Union Wiesenstr.35 4330 Mulheim-Ruhr HENSING Netherlands

Toward a Personal Learning Environment Framework

ERIC Educational Resources Information Center

Chatti, Mohamed Amine; Agustiawan, Mohammad Ridwan; Jarke, Matthias; Specht, Marcus

2010-01-01

Over the past decade, it has been argued that technology-enhanced learning (TEL) could respond to the needs of the new knowledge society and transform learning. However, despite isolated achievements, TEL has not succeeded in revolutionizing education and learning processes. Most current TEL initiatives still take a centralized technology-push…

Direct Commercial and Foreign Military Sales: Chemical Defense Equipment, an Introductory Brochure

DTIC Science & Technology

1991-06-01

60128 CGHCH CM ______________Fax: (86] (028)583-520 COLOMBIA Bogota Tel: [57](1)285-1300/1688 Telex: 44843 ______________Fax: (5711 (1)288-5687...CONSULATES Palermo Tel: (39](91)343-532 Telex: 910313 USA CON I Commercial Section: (39] (91)346-036, 345-1923 Fax: (39] (91)343-546 Florence Tel: [39

Ancient settlements are significant sources of nutrients in Eastern Mediterranean ecosystems - the case of Tel Burna, Israel

NASA Astrophysics Data System (ADS)

Smejda, Ladislav; Hejcman, Michal; Shai, Itzhaq

2016-04-01

Past human settlement activities have caused changes in soil chemical properties that may persist in the cultural soil archive for a very long time and some of them are practically irreversible. We are studying the question if the large-scale mapping of elemental composition based on the surface layer of contemporary soil can reveal spatial patterns corresponding to areas of settlements, which were abandoned even millennia ago. Our case-study is focused on the archaeological site of Tel Burna, located in the Shephelah region, Israel, and its immediate surroundings, making a survey area of 68 ha. The site is known as the town flourishing mainly in the Late Bronze Age and Iron Age (13th-7th centuries BCE). The heyday of the town was during the 10th - 8th centuries BCE, when its summit was enclosed by a massive limestone wall. Later on the significance of the settlement declined, and the architecture vanished. The place has gradually turned to an uninhabited area, used in the recent period as a pasture. We have measured the chemical composition of 350 samples from the surface soil at and around the site by a portable XRF device as part of an on-going interdisciplinary research project studying this site. The results were analysed by standard statistical methods and also in geographical information systems, which were used for calculating models of elemental distribution patterns across the surveyed area. In this paper we discuss the observation that the anthropogenic impact on the chemical composition of soils became quite significant already in times of ancient societies. This human-induced signature was of such magnitude that it can still be detected today, not only in the sub-surface archaeological deposits, but also on the very surface of the present-day landscape. We are able to demonstrate that the nutrients accumulated within the precincts of ancient settlements through the intensive deposition of organic and inorganic waste have been slowly released into local

[Patterns of prescription of opioid analgesics in Hôtel-Dieu de France of Beyrouth].

PubMed

Noufi, P; Khoury, E; Ayoub, E; Naccache, N; Richa, S

2016-12-01

participants were unrelated to prescribing, but those with specialty training and use of practice guidelines were more likely to prescribe opioids and were less reluctant to do so. A majority of practitioners felt that opioids are effective for the treatment of chronic nonmalignant pain and that they have the sufficient training to prescribe them adequately; however, they still worry about the long-term prescription of opioids, particularly fearing the psychological dependence this treatment might cause. Using a series of Spearman correlation tests, we found that practitioners who thought they were adequately trained and who believed in the efficacy of long-term opioid treatment were more likely to prescribe them but that the worries about side effects decreased the frequency of prescription. A significant proportion of practitioners do not evaluate addiction risk factors of patients before prescribing opioids. The results concerning the modalities of follow-up of prescription were very heterogeneous with 87% of practitioners not explaining and 65% not screening for adverse effects. We similarly found that the frequency of follow-up and the management of patients who were exhibiting signs of dependence were very diverse. The results of this study were compatible with those of other recent studies about opioid prescription. The doctors practicing in the university hospital Hôtel-Dieu de France de Beyrouth present comparable prescription patterns, independent of their personal or professional characteristics, and they are more confident in their prescription when professionally trained for it. However, they exhibit a notable heterogeneity in their attitudes towards opioids and in their modalities of evaluating patients receiving long-term treatment. These results suggest a need for additional training in the management of this category of drugs. Copyright © 2016. Published by Elsevier Masson SAS.

A pilot randomized controlled trial of telephone intervention to increase Breast Cancer Screening uptake in socially deprived areas in Scotland (TELBRECS).

PubMed

Chambers, Julie A; Gracie, Kerry; Millar, Rosemary; Cavanagh, Julie; Archibald, Debbie; Cook, Alan; O'Carroll, Ronan E

2016-09-01

To determine whether a brief telephone support intervention could increase breast cancer screening uptake among lower socio-demographic women in Scotland, via eliciting and addressing barriers to screening attendance. In a pilot randomized controlled trial, participants receiving a reminder letter for a missed screening appointment (February-June 2014) were randomized to four arms: No telephone call (control), Simple telephone reminder (TEL), Telephone support (TEL-SUPP), or Telephone support plus anticipated regret (TEL-SUPP-AR). Primary outcomes were making an appointment and attending breast screening. Of 856 women randomized and analysed on intention-to-treat basis, compared with controls, more women in the telephone intervention groups made an appointment (control: 8.8%, TEL: 20.3%, TEL-SUPP: 14.1%; TEL-SUPP-AR: 16.8%, χ(2)(3) = 12.0, p = .007) and attended breast screening (control: 6.9%, TEL: 16.5%, TEL-SUPP: 11.3%; TEL-SUPP-AR: 13.1%, χ(2)(3) = 9.8, p = .020). Of 559 women randomized to the three telephone groups, 404 were successfully contacted and 247 participated in the intervention. Intervention participants (ie. per protocol analysis) were more likely to make (17% versus 10%, χ(2)(1) = 7.0, p = .008) and attend (13% versus 7%, χ(2)(1) = 5.5, p = .019) an appointment than non-participants, but there were no differences in attendance between the three telephone groups. A simple telephone reminder doubled attendance at breast screening in women from lower socio-demographic areas who had not attended their initial appointment, compared with a reminder letter only (odds ratio 2.12, 95% CI (1.2, 3.8)). However, contacting women proved problematic and there was no additional effect of telephone support or anticipated regret. © The Author(s) 2015.

Combining ultrasonography and noncontrast helical computerized tomography to evaluate Holmium laser lithotripsy

PubMed Central

Mi, Jia; Li, Jie; Zhang, Qinglu; Wang, Xing; Liu, Hongyu; Cao, Yanlu; Liu, Xiaoyan; Sun, Xiao; Shang, Mengmeng; Liu, Qing

2016-01-01

Abstract The purpose of the study was to establish a mathematical model for correlating the combination of ultrasonography and noncontrast helical computerized tomography (NCHCT) with the total energy of Holmium laser lithotripsy. In this study, from March 2013 to February 2014, 180 patients with single urinary calculus were examined using ultrasonography and NCHCT before Holmium laser lithotripsy. The calculus location and size, acoustic shadowing (AS) level, twinkling artifact intensity (TAI), and CT value were all documented. The total energy of lithotripsy (TEL) and the calculus composition were also recorded postoperatively. Data were analyzed using Spearman's rank correlation coefficient, with the SPSS 17.0 software package. Multiple linear regression was also used for further statistical analysis. A significant difference in the TEL was observed between renal calculi and ureteral calculi (r = –0.565, P < 0.001), and there was a strong correlation between the calculus size and the TEL (r = 0.675, P < 0.001). The difference in the TEL between the calculi with and without AS was highly significant (r = 0.325, P < 0.001). The CT value of the calculi was significantly correlated with the TEL (r = 0.386, P < 0.001). A correlation between the TAI and TEL was also observed (r = 0.391, P < 0.001). Multiple linear regression analysis revealed that the location, size, and TAI of the calculi were related to the TEL, and the location and size were statistically significant predictors (adjusted r2 = 0.498, P < 0.001). A mathematical model correlating the combination of ultrasonography and NCHCT with TEL was established; this model may provide a foundation to guide the use of energy in Holmium laser lithotripsy. The TEL can be estimated by the location, size, and TAI of the calculus. PMID:27930563

Staging of Macular Telangiectasia: Power-Doppler Optical Coherence Tomography and Macular Pigment Optical Density

PubMed Central

Chin, Eric K.; Kim, Dae Yu; Hunter, Allan A.; Pilli, Suman; Wilson, Machelle; Zawadzki, Robert J.; Werner, John S.; Park, Susanna S.

2013-01-01

Purpose. Two methods were used to study the stages of macular telangiectasia (MacTel): Power-Doppler optical coherence tomography (PD-OCT), which allows imaging of the retinal circulation in three dimensions, and macular pigment optical density (MPOD), which quantifies the distribution of macular carotenoids. Methods. Among 49 patients with MacTel identified, 12 eyes (6 patients) with MacTel and 7 age-matched control eyes (7 patients) were imaged with a custom-built Fourier-domain OCT instrument to acquire PD-OCT images. MPOD was measured using heterochromatic flicker photometry in 10 eyes (5 patients) with MacTel and compared with 44 age-matched control eyes (44 patients). Clinical staging of MacTel was based on best-corrected visual acuity, fundus biomicroscopy, fluorescein angiography, and OCT. Results. Stage 1 eyes (n = 2) had subtle punctate vascular signal confined to the inner portion of the outer plexiform layer (OPL) on PD-OCT. Stage 2 (n = 2) showed larger oblique vascular signal extending into deeper OPL. Stage 3 (n = 5) had disruption of outer retinal layers with abnormal vasculature extending into the outer nuclear layer. Stage 4 (n = 3) showed diffuse blurring of the retinal layers with vascular channels extending the full thickness of the retina. MPOD values in four eyes with stage 1 or 2 MacTel correlated well with age-matched controls. Six eyes with stage 3 or 4 MacTel had loss of MPOD especially at the fovea. Conclusions. PD-OCT shows penetration of the retinal capillaries into the deeper retinal layers in early stages of MacTel, with full thickness vascular proliferation in advanced disease. MPOD is commonly depleted but may appear normal in early stage MacTel. PMID:23716628

Risk behaviors and sexually transmitted diseases in gay and heterosexual men attending an STD clinic in Tel Aviv, Israel: a cross-sectional study.

PubMed

Mor, Zohar; Shohat, Tamy; Goor, Yael; Dan, Michael

2012-03-01

The increase in human immunodeficiency virus (HIV) among men who have sex with men (MSM) in Israel during the last decade raises concerns regarding other sexuallytransmitted diseases (STD) in MSM, which are yet undetermined. To evaluate the STD burden among MSM and heterosexuals visiting the Tel Aviv walk-in STD clinic. Records of all male patients who attended the clinic once were reviewed to identify demographic characteristics, behavioral attributes, and test results. Between 2002 and 2008, 1064 MSM (22%) and 3755 heterosexuals (78%) visited the clinic once. Positivity rates in MSM for HIV, urethral Neisseria gonorrhoea and infectious syphilis were higher than in heterosexuals (2.5%, 2.5%. 0.7% vs. 0.6%, 1.3%, 0.3%, respectively), while urethral Chlamydia trachomatis was higher in heterosexuals than in MSM (2.7% and 1.4%, respectively). MSM tested in our clinic were younger than heterosexuals (P<0.001), more commonly circumcised (P=0.03) and Israeli-born (P<0.001), used substances during sex (P=0.04), and had prior STD (P<0.001), a greater number of sexual partners (P<0.001), and earlier sexual debut (P=0.02). The final multivariate results for MSM to be diagnosed with HIV/STD were greater number of sexual contacts, previous diagnosis with STD, and infrequent use of condom during anal intercourse. MSM visiting the Levinsky Clinic had higher rates of HIV/STD than heterosexual males, which correlated with their higher-risk behaviors. The unique characteristics of MSM found in our study, such as sex work, substance use, previous diagnosis of STD, multiple partners and inconsistent use of condom during anal sex should be addressed with innovative interventions to prevent STD/HIV in the gay community in Israel.

A Report Card on the Economic Literacy of U.S. High School Students.

ERIC Educational Resources Information Center

Walstad, William B.; Soper, John C.

A study of over 3,000 U.S. high school students who took the Test of Economic Literacy (TEL) in 1986 reveals a lack of basic understanding in the four basic TEL concept clusters of fundamental economics, microeconomics, macroeconomics, and international economics. The TEL was administered pre- and posttest where students were enrolled in one of…

Methylation of 23S rRNA Nucleotide G748 by RlmAII Methyltransferase Renders Streptococcus pneumoniae Telithromycin Susceptible

PubMed Central

Sato, Yoshiharu; Shoji, Tatsuma; Yamamoto, Tomoko

2013-01-01

Several posttranscriptional modifications of bacterial rRNAs are important in determining antibiotic resistance or sensitivity. In all Gram-positive bacteria, dimethylation of nucleotide A2058, located in domain V of 23S rRNA, by the dimethyltransferase Erm(B) results in low susceptibility and resistance to telithromycin (TEL). However, this is insufficient to produce high-level resistance to TEL in Streptococcus pneumoniae. Inactivation of the methyltransferase RlmAII, which methylates the N-1 position of nucleotide G748, located in hairpin 35 of domain II of 23S rRNA, results in increased resistance to TEL in erm(B)-carrying S. pneumoniae. Sixteen TEL-resistant mutants (MICs, 16 to 32 μg/ml) were obtained from a clinically isolated S. pneumoniae strain showing low TEL susceptibility (MIC, 2 μg/ml), with mutation resulting in constitutive dimethylation of A2058 because of nucleotide differences in the regulatory region of erm(B) mRNA. Primer extension analysis showed that the degree of methylation at G748 in all TEL-resistant mutants was significantly reduced by a mutation in the gene encoding RlmAII to create a stop codon or change an amino acid residue. Furthermore, RNA footprinting with dimethyl sulfate and a molecular modeling study suggested that methylation of G748 may contribute to the stable interaction of TEL with domain II of 23S rRNA, even after dimethylation of A2058 by Erm(B). This novel finding shows that methylation of G748 by RlmAII renders S. pneumoniae TEL susceptible. PMID:23716046

Methylation of 23S rRNA nucleotide G748 by RlmAII methyltransferase renders Streptococcus pneumoniae telithromycin susceptible.

PubMed

Takaya, Akiko; Sato, Yoshiharu; Shoji, Tatsuma; Yamamoto, Tomoko

2013-08-01

Several posttranscriptional modifications of bacterial rRNAs are important in determining antibiotic resistance or sensitivity. In all Gram-positive bacteria, dimethylation of nucleotide A2058, located in domain V of 23S rRNA, by the dimethyltransferase Erm(B) results in low susceptibility and resistance to telithromycin (TEL). However, this is insufficient to produce high-level resistance to TEL in Streptococcus pneumoniae. Inactivation of the methyltransferase RlmA(II), which methylates the N-1 position of nucleotide G748, located in hairpin 35 of domain II of 23S rRNA, results in increased resistance to TEL in erm(B)-carrying S. pneumoniae. Sixteen TEL-resistant mutants (MICs, 16 to 32 μg/ml) were obtained from a clinically isolated S. pneumoniae strain showing low TEL susceptibility (MIC, 2 μg/ml), with mutation resulting in constitutive dimethylation of A2058 because of nucleotide differences in the regulatory region of erm(B) mRNA. Primer extension analysis showed that the degree of methylation at G748 in all TEL-resistant mutants was significantly reduced by a mutation in the gene encoding RlmA(II) to create a stop codon or change an amino acid residue. Furthermore, RNA footprinting with dimethyl sulfate and a molecular modeling study suggested that methylation of G748 may contribute to the stable interaction of TEL with domain II of 23S rRNA, even after dimethylation of A2058 by Erm(B). This novel finding shows that methylation of G748 by RlmA(II) renders S. pneumoniae TEL susceptible.

A holistic model for evaluating the impact of individual technology-enhanced learning resources.

PubMed

Pickering, James D; Joynes, Viktoria C T

2016-12-01

The use of technology within education has now crossed the Rubicon; student expectations, the increasing availability of both hardware and software and the push to fully blended learning environments mean that educational institutions cannot afford to turn their backs on technology-enhanced learning (TEL). The ability to meaningfully evaluate the impact of TEL resources nevertheless remains problematic. This paper aims to establish a robust means of evaluating individual resources and meaningfully measure their impact upon learning within the context of the program in which they are used. Based upon the experience of developing and evaluating a range of mobile and desktop based TEL resources, this paper outlines a new four-stage evaluation process, taking into account learner satisfaction, learner gain, and the impact of a resource on both the individual and the institution in which it has been adapted. A new multi-level model of TEL resource evaluation is proposed, which includes a preliminary evaluation of need, learner satisfaction and gain, learner impact and institutional impact. Each of these levels are discussed in detail, and in relation to existing TEL evaluation frameworks. This paper details a holistic, meaningful evaluation model for individual TEL resources within the specific context in which they are used. It is proposed that this model is adopted to ensure that TEL resources are evaluated in a more meaningful and robust manner than is currently undertaken.

Chromosomal instability in enterohaemorrhagic Escherichia coli O157:H7: impact on adherence, tellurite resistance and colony phenotype

PubMed Central

Bielaszewska, Martina; Middendorf, Barbara; Tarr, Phillip I; Zhang, Wenlan; Prager, Rita; Aldick, Thomas; Dobrindt, Ulrich; Karch, Helge; Mellmann, Alexander

2011-01-01

Tellurite (Tel) resistant enterohaemorrhagic Escherichia coli (EHEC) O157:H7 is a global pathogen. In strain EDL933 Tel resistance (TelR) is encoded by duplicate ter cluster in O islands (OI) 43 and 48, which also harbour iha, encoding the adhesin and siderophore receptor Iha. We identified five EHEC O157:H7 strains that differentiate into large (L) colonies and small (S) colonies with high and low Tel minimal inhibitory concentrations (MICs) respectively. S colonies (Tel-MICs ≤ 4 µg ml−1) sustained large internal deletions within the TelR OIs via homologous recombination between IS elements and lost ter and iha. Moreover, complete excision of the islands occurred by site-specific recombination between flanking direct repeats. Complete excision of OI 43 and OI 48 occurred in 1.81 × 10−3 and 1.97 × 10−4 cells in culture, respectively; internal deletion of OI 48 was more frequent (9.7 × 10−1 cells). Under iron limitation that promotes iha transcription, iha-negative derivatives adhered less well to human intestinal epithelial cells and grew slower than did their iha-positive counterparts. Experiments utilizing iha deletion and complementation mutants identified Iha as the major factor responsible for these phenotypic differences. Spontaneous deletions affecting TelR OIs contribute to EHEC O157 genome plasticity and might impair virulence and/or fitness. PMID:21299654

A novel vesicular carrier, transethosome, for enhanced skin delivery of voriconazole: characterization and in vitro/in vivo evaluation.

PubMed

Song, Chung Kil; Balakrishnan, Prabagar; Shim, Chang-Koo; Chung, Suk-Jae; Chong, Saeho; Kim, Dae-Duk

2012-04-01

This study describes a novel carrier, transethosome, for enhanced skin delivery of voriconazole. Transethosomes (TELs) are composed of phospholipid, ethanol, water and edge activator (surfactants) or permeation enhancer (oleic acid). Characterization of the TELs was based on results from recovery, particle size, transmission electron microscopy (TEM), zeta potential and elasticity studies. In addition, skin permeation profile was obtained using static vertical diffusion Franz cells and hairless mouse skin treated with TELs containing 0.3% (w/w) voriconazole, and compared with those of ethosomes (ELs), deformable liposomes (DLs), conventional liposomes (CLs) and control (polyethylene glycol, PG) solutions. The recovery of the studied vesicles was above 90% in all vesicles, as all of them contained ethanol (7-30%). There was no significant difference in the particles size of all vesicles. The TEM study revealed that the TELs were in irregular spherical shape, implying higher fluidity due to perturbed lipid bilayer compared to that of other vesicles which were of spherical shape. The zeta potential of vesicles containing sodium taurocholate or oleic acid showed higher negative value compared to other vesicles. The elasticities of ELs and TELs were much higher than that of CLs and DLs. Moreover, TELs dramatically enhanced the skin permeation of voriconazole compared to the control and other vesicles (p<0.05). Moreover, the TELs enhanced both in vitro and in vivo skin deposition of voriconazole in the dermis/epidermis region compared to DLs, CLs and control. Therefore, based on the current study, the novel carrier TELs could serve as an effective dermal delivery for voriconazole. Copyright © 2011 Elsevier B.V. All rights reserved.

Ultrastructural and clinical evidence of subretinal debris accumulation in type 2 macular telangiectasia.

PubMed

Cherepanoff, Svetlana; Killingsworth, Murray C; Zhu, Meidong; Nolan, Timothy; Hunyor, Alex P; Young, Stephanie H; Hageman, Gregory S; Gillies, Mark C

2012-11-01

To describe subretinal debris found on ultrastructural examination in an eye with macular telangiectasia (MacTel) type 2 and on optical coherence tomography (OCT) in a subset of patients with MacTel type 2. Blocks from the mid-periphery and temporal perifovea of an eye with clinically documented MacTel type 2 were examined with electron microscopy (EM). Cases came from the Sydney centre of the MacTel project and the practices of the authors. On EM examination, subretinal debris was found in the perifovea with accumulation of degenerate photoreceptor elements in the subretinal space. Despite the substantial subretinal debris, there was minimal retinal pigment epithelial (RPE) reaction. Focal defects were seen in the inner limiting membrane in the perifovea. Of the 65 Sydney MacTel project participants, three (5%) had prominent yellow material at the fovea. OCT revealed smooth mounds between the RPE and the ellipsoid region. The material was hyperautofluorescent. This study suggests that subretinal accumulation of photoreceptor debris may be a feature of MacTel type 2. Ultrastructural and OCT evidence of disease beyond the vasculature, involving photoreceptors and Muller cells, is presented.

Evidence-Based Principles for Using Technology-Enhanced Learning in the Continuing Professional Development of Health Professionals.

PubMed

Scott, Karen M; Baur, Louise; Barrett, Jenny

2017-01-01

Increasingly, health professional training involves the use of educational technologies through what is broadly termed "Technology-Enhanced Learning" (TEL). TEL includes hardware, such as computers and mobile devices, and software, such as software applications (apps), learning management systems, and discussion boards. For many years, TEL has formed an integral part of health professional programs and is growing in acceptance, if not expectation, in postgraduate training and continuing education. TEL generally aims to be flexible, engaging, learner focused and interactive, and may involve collaboration and communication. It offers many benefits for learning and teaching, whether used on its own or in conjunction with face-to-face teaching through blended learning. The ubiquity of mobile devices in clinical settings means TEL is ideal for busy clinicians, both as learners and teachers. TEL enables participants to learn at a time and place that is convenient to them, so learners living in geographically dispersed locations can access standardized courses. To realize these potential benefits, we recommend that those developing TEL programs for health professionals take a systematic approach to planning, development, implementation, and evaluation. To that end, we propose 10 principles: clarify purpose and conduct a needs assessment; allocate adequate time and technology; incorporate proven approaches to improve learning; consider the need for a skills component; enable interaction between learners and with others; create different resources for different groups; pilot before implementing; incorporate measures to retain learners; provide opportunities for revision to aid retention; and evaluate learning outcomes, not just satisfaction.

Stories in the Data.

PubMed

Singh, Gary

2017-01-01

To some degree, comics have always been used to convert data into stories, from ancient Egyptian heiroglyphics to crude biology diagrams in grade-school textbooks. By their very nature, comics communicate through a variety of visualization techniques. Benjamin Bach, who along with his coauthors Nathalie Henry Riche, Sheelagh Carpendale, and Hanspeter Pfister created this issue's Art on Graphics special contribution about the emerging genre of data comics, here talks about their attempts to leverage the massive untapped potential for data-driven comics to explain multiple threads of simultaneous data.

Spectroscopic study of fluorescent probes based on G-quadruplex oligonucleotides labeled with ethynylpyrenyldeoxyuridine.

PubMed

Switalska, Angelika; Kierzek, Ryszard; Dembska, Anna; Juskowiak, Bernard

2017-12-01

The design, synthesis, and spectral properties of four pyrene labeled oligonucleotide probes with G-quadruplex structure (Tel22-Tpy, Tel22-Upy, Tel22-6Upy, Tel22-18Upy) based on the 22-mer human telomeric sequence (Tel22) have been reported. Pyrene labels in the form of ethynylpyrenyldeoxyuridine have been inserted efficiently into oligodeoxynucleotides probes using phosphoramidite chemistry. The probes exhibited abilities to fold into G-quadruplex structures and to bind metal cations (Na + and K + ). Folding properties of probes and their spectral behavior were examined by recording the UV-vis, fluorescence, and CD spectra as well as by analyzing melting profiles. Fluorescence characteristics and G-quadruplex folding of probes were also studied at the interface of cationic dioctadecyldimethylammonium bromide (DODAB) monolayer. Investigations included film balance measurements (π-A isotherms) and fluorescence spectra recording using a fiber optic accessory interfaced with a spectrofluorimeter. Copyright © 2017 Elsevier B.V. All rights reserved.

Evaluation of Technology-Enhanced Learning Programs for Health Care Professionals: Systematic Review

PubMed Central

MacRury, Sandra; van Woerden, Hugo C; Smyth, Keith

2018-01-01

Background Technology-enhanced learning (TEL) programs are increasingly seen as the way in which education for health care professionals can be transformed, giving access to effective ongoing learning and training even where time or geographical barriers exist. Given the increasing emphasis on this mode of educational support for health care practitioners, it is vital that we can effectively evaluate and measure impact to ensure that TEL programs are effective and fit for purpose. This paper examines the current evidence base for the first time, in relation to the evaluation of TEL programs for health care professionals. Objective We conducted a systematic review of the current literature relating to the evaluation of TEL programs for health care professionals and critically appraised the quality of the studies. Methods This review employed specific search criteria to identify research studies that included evaluation of TEL for health care professionals. The databases searched included Medline Ovid, Cumulative Index of Nursing and Allied Health Literature Plus Advanced, Applied Social Sciences Index and Abstracts, ZETOC, Institute of Electrical and Electronics Engineers Explore Digital Library, Allied and Complementary Medicine, and Education Resources Information Center between January 2006 and January 2017. An additional hand search for relevant articles from reference lists was undertaken. Each of the studies identified was critically appraised for quality using the Crowe Critical Appraisal Tool. This approach produced a percentage total score for each study across specified categories. A proportion of the studies were independently assessed by an additional two reviewers. Results The review identified 21 studies that met the inclusion criteria. The studies included scored totals across eight categories within a range of 37%-95% and an average score of 68%. Studies that measured TEL using learner satisfaction surveys, or combined pretest and posttest knowledge

Evaluation of Technology-Enhanced Learning Programs for Health Care Professionals: Systematic Review.

PubMed

Nicoll, Pam; MacRury, Sandra; van Woerden, Hugo C; Smyth, Keith

2018-04-11

Technology-enhanced learning (TEL) programs are increasingly seen as the way in which education for health care professionals can be transformed, giving access to effective ongoing learning and training even where time or geographical barriers exist. Given the increasing emphasis on this mode of educational support for health care practitioners, it is vital that we can effectively evaluate and measure impact to ensure that TEL programs are effective and fit for purpose. This paper examines the current evidence base for the first time, in relation to the evaluation of TEL programs for health care professionals. We conducted a systematic review of the current literature relating to the evaluation of TEL programs for health care professionals and critically appraised the quality of the studies. This review employed specific search criteria to identify research studies that included evaluation of TEL for health care professionals. The databases searched included Medline Ovid, Cumulative Index of Nursing and Allied Health Literature Plus Advanced, Applied Social Sciences Index and Abstracts, ZETOC, Institute of Electrical and Electronics Engineers Explore Digital Library, Allied and Complementary Medicine, and Education Resources Information Center between January 2006 and January 2017. An additional hand search for relevant articles from reference lists was undertaken. Each of the studies identified was critically appraised for quality using the Crowe Critical Appraisal Tool. This approach produced a percentage total score for each study across specified categories. A proportion of the studies were independently assessed by an additional two reviewers. The review identified 21 studies that met the inclusion criteria. The studies included scored totals across eight categories within a range of 37%-95% and an average score of 68%. Studies that measured TEL using learner satisfaction surveys, or combined pretest and posttest knowledge score testing with learner

77 FR 71777 - Trade Mission to Egypt and Kuwait

Federal Register 2010, 2011, 2012, 2013, 2014

2012-12-04

... been determined that additional time is needed to allow for additional recruitment and marketing in... States of America, Email: [email protected] , Tel: Washington, DC, Tel: (202) 482-8178, Email: 2...

Comparison of ambulatory and polysomnographic recording of jaw muscle activity during sleep in normal subjects.

PubMed

Yamaguchi, T; Abe, S; Rompré, P H; Manzini, C; Lavigne, G J

2012-01-01

Clinicians and investigators need a simple and reliable recording device to diagnose or monitor sleep bruxism (SB). The aim of this study was to compare recordings made with an ambulatory electromyographic telemetry recorder (TEL-EMG) with those made with standard sleep laboratory polysomnography with synchronised audio-visual recording (PSG-AV). Eight volunteer subjects without current history of tooth grinding spent one night in a sleep laboratory. Simultaneous bilateral masseter EMG recordings were made with a TEL-EMG and standard PSG. All types of oromotor activity and rhythmic masseter muscle activity (RMMA), typical of SB, were independently scored by two individuals. Correlation and intra-class coefficient (ICC) were estimated for scores on each system. The TEL-EMG was highly sensitive to detect RMMA (0·988), but with low positive predictive value (0·231) because of a high rate of oromotor activity detection (e.g. swallowing and scratching). Almost 72% of false-positive oromotor activity scored with the TEL-EMG occurred during the transient wake period of sleep. A non-significant correlation between recording systems was found (r = 0·49). Because of the high frequency of wake periods during sleep, ICC was low (0·47), and the removal of the influence of wake periods improved the detection reliability of the TEL-EMG (ICC = 0·88). The TEL-EMG is sensitive to detect RMMA in normal subjects. However, it obtained a high rate of false-positive detections because of the presence of frequent oromotor activities and transient wake periods of sleep. New algorithms are needed to improve the validity of TEL-EMG recordings. © 2011 Blackwell Publishing Ltd.

The CIRP International Workshop on Concurrent Engineering for Product Realization (1st) Held in Tokyo, Japan on June 27 - 28, 1992

DTIC Science & Technology

1992-11-01

7075 Dr. Samuel K.M.HO Dept. of Engineering Warwick University Coventry CV 47 AL UK 15 Tel.(44)203 524173 Fax.(44)203 524307 Mr. Mikio Inagaki...Nishi-8, Kita-ku Sapporo 060, JAPAN Tel. +81-11-716-211 ex.6447 Fax. +81-11-758-1619 Mr. Mikio Kitano 16 Motomachi Plant Toyota Moter Corporation 1...Hirosawa 2-1, Wako, Saitama 351-01 JAPAN Tel 81-484-65-6641 Fax 81-484-67-5942 Professor Hisayoshi Sato Director, Mechanical Engineering Laboratory

Fahr's Syndrome

MedlinePlus

... 55 Kenosia Avenue Danbury CT Danbury, CT 06810 orphan@rarediseases.org http://rarediseases.org Tel: 203-744- ... 55 Kenosia Avenue Danbury CT Danbury, CT 06810 orphan@rarediseases.org http://rarediseases.org Tel: 203-744- ...

Neuroleptic Malignant Syndrome

MedlinePlus

... 55 Kenosia Avenue Danbury CT Danbury, CT 06810 orphan@rarediseases.org http://rarediseases.org Tel: 203-744- ... 55 Kenosia Avenue Danbury CT Danbury, CT 06810 orphan@rarediseases.org http://rarediseases.org Tel: 203-744- ...

Knowledge, attitudes, sexual practices and STI/HIV prevalence in male sex workers and other men who have sex in Tel Aviv, Israel: a cross-sectional study.

PubMed

Mor, Zohar; Dan, Michael

2012-12-01

To explore knowledge, attitudes and sexual practices of male sex workers (MSW) in Tel Aviv in comparison with men who have sex with men (MSM) classified by their risk behaviours and to outline attributes related to sexually transmitted infections (STI)/HIV prevalence. MSW were recruited for this cross-sectional study from designated street venues and gay-dating internet site. MSM were recruited from gay-related venues and divided into high-risk MSM (HRMSM) if they performed unprotected anal intercourse in the last 6 months with an HIV-discordant/unknown partner and to low-risk MSM (LRMSM). Each participant completed a questionnaire and was tested for STI/HIV. Of 87 MSW and 635 MSM approached, 53 (60.9%) and 235 (37.0%) participated, respectively. Street-MSW (N=32) had more female sex partners and were more drug dependent than internet-MSW (N=21). No differences were found in their knowledge regarding STI/HIV transmission, practices and STI/HIV burden. Compared with HRMSM, MSW had different demographic attributes and demonstrated more realistic perception regarding the risk to getting STI/HIV, while no differences were found in their knowledge and sexual practices. STI burden among MSW, HRMSM (N=119) and LRMSM (N=116) were 28.3%, 23.5% and 10.3% (p=0.009) and HIV burden among MSW, HRMSM and LRMSM were 5.6%, 9.2% and 0%, (p=0.001), respectively. Multivariate models evaluating attributes associated with HIV/STI diagnosis did not find sex work to be significant if the variable used was MSW versus HRMSM, regardless of the adjustments performed. However, when MSW versus LRMSM was used in the model, sex work was associated with STI/HIV diagnosis. Street-MSW and internet-MSW, similar to all MSW and HRMSM, had comparable sexual practices and had no difference in their STI/HIV prevalence.

Equatorial Scintillation Predictions from C/NOFS Planar Langmuir Probe Electron Density Fluctuation Data

DTIC Science & Technology

2014-09-05

Brasil Tel: 55 21 3527 1682; Fax: 55 21 3527 1154 E-mail: epoc@cetuc.puc-rio.br FINAL PERFORMANCE REPORT Equatorial scintillation...Costa Centro de Estudos em Telecomunicações/CETUC Rua Marquês de São Vicente, 225 – Gávea 22451-900 Rio de Janeiro - RJ – Brasil Tel: 55 21 3527...Emanoel Costa Centro de Estudos em Telecomunicações/CETUC Rua Marquês de São Vicente, 225 – Gávea 22451-900 Rio de Janeiro - RJ – Brasil Tel: 55

Poster Day Showcases Student Work | Poster

Cancer.gov

By Nathalie Walker, Guest Writer, and Carolynne Keenan, Contributing Writer On July 31, NCI at Frederick hosted Student Poster Day, an annual event in which student interns can showcase the work they do in their various positions in NCI at Frederick labs and offices. Participating students are interns in the Student Internship Program, a program designed for undergraduate and graduate students during their summer breaks, as well as interns in the Werner H. Kirsten Student Internship Program (WHK SIP), a program for high school seniors. All the students have an opportunity to present their scientific posters.

TELS: Teaching Essential Life Skills.

ERIC Educational Resources Information Center

Randolph Township Schools, NJ.

This guide was designed to provide classroom-level applications that can be utilized in the education of students in kindergarten through grade six. The purpose of the guide is to develop an educational process with a focus on technology education and problem solving skills that enhances the curriculum, instills in students an awareness of the…

How comprehensive are research studies investigating the efficacy of technology-enhanced learning resources in anatomy education? A systematic review.

PubMed

Clunie, Lauren; Morris, Neil P; Joynes, Viktoria C T; Pickering, James D

2018-05-06

Anatomy education is at the forefront of integrating innovative technologies into its curricula. However, despite this rise in technology numerous authors have commented on the shortfall in efficacy studies to assess the impact such technology-enhanced learning (TEL) resources have on learning. To assess the range of evaluation approaches to TEL across anatomy education, a systematic review was conducted using MEDLINE, the Educational Resources Information Centre (ERIC), Scopus, and Google Scholar, with a total of 3,345 articles retrieved. Following the PRISMA method for reporting items, 153 articles were identified and reviewed against a published framework-the technology-enhanced learning evaluation model (TELEM). The model allowed published reports to be categorized according to evaluations at the level of (1) learner satisfaction, (2) learning gain, (3) learner impact, and (4) institutional impact. The results of this systematic review reveal that most evaluation studies into TEL within anatomy curricula were based on learner satisfaction, followed by module or course learning outcomes. Randomized controlled studies assessing learning gain with a specific TEL resource were in a minority, with no studies reporting a comprehensive assessment on the overall impact of introducing a specific TEL resource (e.g., return on investment). This systematic review has provided clear evidence that anatomy education is engaged in evaluating the impact of TEL resources on student education, although it remains at a level that fails to provide comprehensive causative evidence. Anat Sci Educ 11: 303-319. © 2017 American Association of Anatomists. © 2017 American Association of Anatomists.

RlmCD-mediated U747 methylation promotes efficient G748 methylation by methyltransferase RlmAII in 23S rRNA in Streptococcus pneumoniae; interplay between two rRNA methylations responsible for telithromycin susceptibility

PubMed Central

Shoji, Tatsuma; Takaya, Akiko; Sato, Yoshiharu; Kimura, Satoshi; Suzuki, Tsutomu; Yamamoto, Tomoko

2015-01-01

Adenine at position 752 in a loop of helix 35 from positions 745 to 752 in domain II of 23S rRNA is involved in binding to the ribosome of telithromycin (TEL), a member of ketolides. Methylation of guanine at position 748 by the intrinsic methyltransferase RlmAII enhances binding of telithromycin (TEL) to A752 in Streptococcus pneumoniae. We have found that another intrinsic methylation of the adjacent uridine at position 747 enhances G748 methylation by RlmAII, rendering TEL susceptibility. U747 and another nucleotide, U1939, were methylated by the dual-specific methyltransferase RlmCD encoded by SP_1029 in S. pneumoniae. Inactivation of RlmCD reduced N1-methylated level of G748 by RlmAII in vivo, leading to TEL resistance when the nucleotide A2058, located in domain V of 23S rRNA, was dimethylated by the dimethyltransferase Erm(B). In vitro methylation of rRNA showed that RlmAII activity was significantly enhanced by RlmCD-mediated pre-methylation of 23S rRNA. These results suggest that RlmCD-mediated U747 methylation promotes efficient G748 methylation by RlmAII, thereby facilitating TEL binding to the ribosome. PMID:26365244

Effects of a mobile phone short message service on antiretroviral treatment adherence in Kenya (WelTel Kenya1): a randomised trial.

PubMed

Lester, Richard T; Ritvo, Paul; Mills, Edward J; Kariri, Antony; Karanja, Sarah; Chung, Michael H; Jack, William; Habyarimana, James; Sadatsafavi, Mohsen; Najafzadeh, Mehdi; Marra, Carlo A; Estambale, Benson; Ngugi, Elizabeth; Ball, T Blake; Thabane, Lehana; Gelmon, Lawrence J; Kimani, Joshua; Ackers, Marta; Plummer, Francis A

2010-11-27

Mobile (cell) phone communication has been suggested as a method to improve delivery of health services. However, data on the effects of mobile health technology on patient outcomes in resource-limited settings are limited. We aimed to assess whether mobile phone communication between health-care workers and patients starting antiretroviral therapy in Kenya improved drug adherence and suppression of plasma HIV-1 RNA load. WelTel Kenya1 was a multisite randomised clinical trial of HIV-infected adults initiating antiretroviral therapy (ART) in three clinics in Kenya. Patients were randomised (1:1) by simple randomisation with a random number generating program to a mobile phone short message service (SMS) intervention or standard care. Patients in the intervention group received weekly SMS messages from a clinic nurse and were required to respond within 48 h. Randomisation, laboratory assays, and analyses were done by investigators masked to treatment allocation; however, study participants and clinic staff were not masked to treatment. Primary outcomes were self-reported ART adherence (>95% of prescribed doses in the past 30 days at both 6 and 12 month follow-up visits) and plasma HIV-1 viral RNA load suppression (<400 copies per mL) at 12 months. The primary analysis was by intention to treat. This trial is registered with ClinicalTrials.gov, NCT00830622. Between May, 2007, and October, 2008, we randomly assigned 538 participants to the SMS intervention (n=273) or to standard care (n=265). Adherence to ART was reported in 168 of 273 patients receiving the SMS intervention compared with 132 of 265 in the control group (relative risk [RR] for non-adherence 0·81, 95% CI 0·69-0·94; p=0·006). Suppressed viral loads were reported in 156 of 273 patients in the SMS group and 128 of 265 in the control group, (RR for virologic failure 0·84, 95% CI 0·71-0·99; p=0·04). The number needed to treat (NNT) to achieve greater than 95% adherence was nine (95% CI 5·0-29·5

Cyber Infrastructure Protection

DTIC Science & Technology

2011-05-01

274 TOWARD A SOLUTION THAT WORKS Building on our long history of involvement in assuring all types of communications networks, Tel- cordia has...wireless, and security areas. He currently has responsibility for a new Tel- cordia software product in IP network management, and has led all product

75 FR 34630 - Iranian Transactions Regulations

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-18

..., Assistant Director for Licensing, tel.: 202/622-2480, Assistant Director for Policy, tel.: 202/622-4855... actively supporting terrorism as an instrument of state policy, the President prohibited the importation of...) (``IEEPA''), the President declared a national emergency with respect to the actions and policies of the...

Measurements of a Newly Designed BPM for the Tevatron Electron Lens 2

DOE Office of Scientific and Technical Information (OSTI.GOV)

Scarpine, V. E.; Kamerdzhiev, V.; Fellenz, B.

2006-11-20

Fermilab has developed a second electron lens (TEL-2) for beam-beam compensation in the Tevatron as part of its Run II upgrade program. Operation of the beam position monitors (BPMs) in the first electron lens (TEL-1) showed a systematic transverse position difference between short proton bunches (2 ns sigma) and long electron pulses ({approx}1 us) of up to {approx}1.5 mm. This difference was attributed to frequency dependence in the BPM system. The TEL-2 BPMs utilize a new, compact four-plate design with grounding strips between plates to minimize crosstalk. In-situ measurements of these new BPMs are made using a stretched wire pulsedmore » with both proton and electron beam formats. In addition, longitudinal impedance measurements of the TEL-2 are presented. Signal processing algorithm studies indicate that the frequency-dependent transverse position offset may be reduced to {approx}0.1 mm for the beam structures of interest.« less

Measurements of a Newly Designed BPM for the Tevatron Electron Lens 2

NASA Astrophysics Data System (ADS)

Scarpine, V. E.; Kamerdzhiev, V.; Fellenz, B.; Olson, M.; Kuznetsov, G.; Kamerdzhiev, V.; Shiltsev, V. D.; Zhang, X. L.

2006-11-01

Fermilab has developed a second electron lens (TEL-2) for beam-beam compensation in the Tevatron as part of its Run II upgrade program. Operation of the beam position monitors (BPMs) in the first electron lens (TEL-1) showed a systematic transverse position difference between short proton bunches (2 ns sigma) and long electron pulses (˜1 us) of up to ˜1.5 mm. This difference was attributed to frequency dependence in the BPM system. The TEL-2 BPMs utilize a new, compact four-plate design with grounding strips between plates to minimize crosstalk. In-situ measurements of these new BPMs are made using a stretched wire pulsed with both proton and electron beam formats. In addition, longitudinal impedance measurements of the TEL-2 are presented. Signal processing algorithm studies indicate that the frequency-dependent transverse position offset may be reduced to ˜0.1 mm for the beam structures of interest.

Late-glacial and early Holocene changes in vegetation and lake-level at Hauterive/Rouges-Terres, Lake Neuchâtel (Switzerland)

NASA Astrophysics Data System (ADS)

Magny, Michel; Thew, Nigel; Hadorn, Philippe

2003-01-01

Palynological and sedimentological analyses of a sedimentary sequence sampled at Hauterive/Rouges-Terres, Lake Neuchâtel (Switzerland) provide documentation of changes in vegetation and lake-level during the Bølling, Younger Dryas and Preboreal pollen zones, and have allowed a comparison with sequences covering the same period from other sites located in the western part of the Swiss Plateau. The Juniperus-Hippophaë zone (regional pollen assemblage zone (RPAZ) CHb-2, first part of the Bølling, ca. 14 650-14 450 cal. yr BP) was characterised by a generally low lake-level. A weak rise occurred during this zone. The Juniperus-Hippophaë to Betula zone transition coincided with a lake-level lowering, interrupted by a short-lived but marked phase of higher lake-level recorded at the neighbouring site of Hauterive-Champréveyres, but not present at Hauterive/Rouges-Terres owing to an erosion surface. Shortly after the beginning of the Betula zone (RPAZ CHb-3, second part of the Bølling, ca 14 450-14 000 cal. yr BP), a marked rise in lake-level occurred. It was composed of two successive periods of higher level, coinciding with high values of Betula, separated by a short episode of relatively lower lake-level associated with raised values in Artemisia and other non-arboreal pollen. The last part of RPAZ CHb-3 saw a fall in lake-level. The lower lake-levels during RPAZ CHb-2 to early RPAZ CHb-3 can be correlated with the abrupt warming at the beginning of the Greenland Interstadial (GI) 1e thermal maximum. The successive episodes of higher lake-level punctuating the GI 1e might be linked to the so-called Intra-Bølling Cold Oscillations identified from several palaeoclimatic records in the North Atlantic area, and also documented in oxygen-isotope data sets from Swiss Plateau lakes. The Hauterive/Rouges-Terres lake-level record provides evidence for marked climatic drying through the second part of the Younger Dryas event (GS1), during the GS1-Preboreal (RPAZ CHb-4b-4

Acceptance of technology-enhanced learning for a theoretical radiological science course: a randomized controlled trial.

PubMed

Nkenke, Emeka; Vairaktaris, Elefterios; Bauersachs, Anne; Eitner, Stephan; Budach, Alexander; Knipfer, Christoph; Stelzle, Florian

2012-03-30

Technology-enhanced learning (TEL) gives a view to improved education. However, there is a need to clarify how TEL can be used effectively. The study compared students' attitudes and opinions towards a traditional face-to-face course on theoretical radiological science and a TEL course where students could combine face-to-face lectures and e-learning modules at their best convenience. 42 third-year dental students were randomly assigned to the traditional face-to-face group and the TEL group. Both groups completed questionnaires before the beginning and after completion of the course on attitudes and opinions towards a traditional face-to-face lectures and technology-enhanced learning. After completion of the course both groups also filled in the validated German-language TRIL (Trierer Inventar zur Lehrevaluation) questionnaire for the evaluation of courses given at universities. Both groups had a positive attitude towards e-learning that did not change over time. The TEL group attended significantly less face-to-face lectures than the traditional group. However, both groups stated that face-to-face lectures were the basis for education in a theoretical radiological science course. The members of the TEL group rated e-mail reminders significantly more important when they filled in the questionnaire on attitudes and opinions towards a traditional face-to-face lectures and technology-enhanced learning for the second time after completion of the course. The members of the technology-enhanced learning group were significantly less confident in passing the exam compared to the members of the traditional group. However, examination results did not differ significantly for traditional and the TEL group. It seems that technology-enhanced learning in a theoretical radiological science course has the potential to reduce the need for face-to-face lectures. At the same time examination results are not impaired. However, technology-enhanced learning cannot completely replace

Acceptance of technology-enhanced learning for a theoretical radiological science course: a randomized controlled trial

PubMed Central

2012-01-01

Background Technology-enhanced learning (TEL) gives a view to improved education. However, there is a need to clarify how TEL can be used effectively. The study compared students' attitudes and opinions towards a traditional face-to-face course on theoretical radiological science and a TEL course where students could combine face-to-face lectures and e-learning modules at their best convenience. Methods 42 third-year dental students were randomly assigned to the traditional face-to-face group and the TEL group. Both groups completed questionnaires before the beginning and after completion of the course on attitudes and opinions towards a traditional face-to-face lectures and technology-enhanced learning. After completion of the course both groups also filled in the validated German-language TRIL (Trierer Inventar zur Lehrevaluation) questionnaire for the evaluation of courses given at universities. Results Both groups had a positive attitude towards e-learning that did not change over time. The TEL group attended significantly less face-to-face lectures than the traditional group. However, both groups stated that face-to-face lectures were the basis for education in a theoretical radiological science course. The members of the TEL group rated e-mail reminders significantly more important when they filled in the questionnaire on attitudes and opinions towards a traditional face-to-face lectures and technology-enhanced learning for the second time after completion of the course. The members of the technology-enhanced learning group were significantly less confident in passing the exam compared to the members of the traditional group. However, examination results did not differ significantly for traditional and the TEL group. Conclusions It seems that technology-enhanced learning in a theoretical radiological science course has the potential to reduce the need for face-to-face lectures. At the same time examination results are not impaired. However, technology

Ontology Extraction Tools: An Empirical Study with Educators

ERIC Educational Resources Information Center

Hatala, M.; Gasevic, D.; Siadaty, M.; Jovanovic, J.; Torniai, C.

2012-01-01

Recent research in Technology-Enhanced Learning (TEL) demonstrated several important benefits that semantic technologies can bring to the TEL domain. An underlying assumption for most of these research efforts is the existence of a domain ontology. The second unspoken assumption follows that educators will build domain ontologies for their…

Identifying Areas of Tension in the Field of Technology-Enhanced Learning: Results of an International Delphi Study

ERIC Educational Resources Information Center

Plesch, Christine; Kaendler, Celia; Rummel, Nikol; Wiedmann, Michael; Spada, Hans

2013-01-01

Despite steady progress in research in technology-enhanced learning (TEL), the translation of research findings and technology into educational practices falls short of expectations. We present five Areas of Tension which were identified and evaluated in an international Delphi study on TEL. These tensions might impede a more comprehensive…

Moving Technology-Enhanced-Learning Forward: Bridging Divides through Leadership

ERIC Educational Resources Information Center

Bälter, Olle

2017-01-01

A study of academics and professional staff engaged in the emerging field of Technology Enhanced Learning (TEL) reveal three areas of significant difference in reference to perspectives about TEL. These differences rest on the following individual characteristics: 1) research areas and competencies, 2) academic level, and 3) attitudes towards…

Studies of Heat Transfer in Complex Internal Flows.

DTIC Science & Technology

1982-01-01

D.C. 20362 (Tel 202-692-6874) Mr. Richard S. Carlton Director, Engines Division, Code 523 NC #4 Naval Sea Systems Command Washington, D.C. 20362...Walter Ritz Code 033C Naval Ships Systems Engineering Station Philadelphia, Pennsylvania 19112 (Tel. 215-755-3841) Dr. Simion Kuo United Tech. Res

The Potential Relevance of Cognitive Neuroscience for the Development and Use of Technology-Enhanced Learning

ERIC Educational Resources Information Center

Howard-Jones, Paul; Ott, Michela; van Leeuwen, Theo; De Smedt, Bert

2015-01-01

There is increasing interest in the application of cognitive neuroscience in educational thinking and practice, and here we review findings from neuroscience that demonstrate its potential relevance to technology-enhanced learning (TEL). First, we identify some of the issues in integrating neuroscientific concepts into TEL research. We caution…

Evaluating Recommender Systems for Technology Enhanced Learning: A Quantitative Survey

ERIC Educational Resources Information Center

Erdt, Mojisola; Fernandez, Alejandro; Rensing, Christoph

2015-01-01

The increasing number of publications on recommender systems for Technology Enhanced Learning (TEL) evidence a growing interest in their development and deployment. In order to support learning, recommender systems for TEL need to consider specific requirements, which differ from the requirements for recommender systems in other domains like…

Contextualizing Learning Scenarios According to Different Learning Management Systems

ERIC Educational Resources Information Center

Drira, R.; Laroussi, M.; Le Pallec, X.; Warin, B.

2012-01-01

In this paper, we first demonstrate that an instructional design process of Technology Enhanced Learning (TEL) systems based on a Model Driven Approach (MDA) addresses the limits of Learning Technology Standards (LTS), such as SCORM and IMS-LD. Although these standards ensure the interoperability of TEL systems across different Learning Management…

The 3P Learning Model

ERIC Educational Resources Information Center

Chatti, Mohamed Amine; Jarke, Matthias; Specht, Marcus

2010-01-01

Recognizing the failures of traditional Technology Enhanced Learning (TEL) initiatives to achieve performance improvement, we need to rethink how we design new TEL models that can respond to the learning requirements of the 21st century and mirror the characteristics of knowledge and learning which are fundamentally personal, social, distributed,…

Modelling Benefits-Oriented Costs for Technology Enhanced Learning

ERIC Educational Resources Information Center

Laurillard, Diana

2007-01-01

The introduction of technology enhanced learning (TEL) methods changes the deployment of the most important resource in the education system: teachers' and learners' time. New technology promises greater personalization and greater productivity, but without careful modeling of the effects on the use of staff time, TEL methods can easily increase…

78 FR 48862 - Agency Information Collection Activities; Submission to the Office of Management and Budget for...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-12

...; Submission to the Office of Management and Budget for Review and Approval; Comment Request; NAEP Wave 2 (TEL... issues: (1) Is this collection necessary to the proper functions of the Department; (2) will this... notice will be considered public records. Title of Collection: NAEP Wave 2 (TEL and Assessment Feedback...

Influencing Factors for Adopting Technology Enhanced Learning in the Medical Schools of Punjab, Pakistan

ERIC Educational Resources Information Center

Iqbal, Shazia; Ahmad, Shahzad; Willis, Ian

2017-01-01

As the successful establishment of technology supported educational systems requires wide investment in terms of finances and faculty time, this study explores the influencing factors in the adoption of Technology Enhanced Learning (TEL) and the main barriers encountered during the use of TEL in Punjab, Pakistan. Semi-structured interviews were…

RlmCD-mediated U747 methylation promotes efficient G748 methylation by methyltransferase RlmAII in 23S rRNA in Streptococcus pneumoniae; interplay between two rRNA methylations responsible for telithromycin susceptibility.

PubMed

Shoji, Tatsuma; Takaya, Akiko; Sato, Yoshiharu; Kimura, Satoshi; Suzuki, Tsutomu; Yamamoto, Tomoko

2015-10-15

Adenine at position 752 in a loop of helix 35 from positions 745 to 752 in domain II of 23S rRNA is involved in binding to the ribosome of telithromycin (TEL), a member of ketolides. Methylation of guanine at position 748 by the intrinsic methyltransferase RlmA(II) enhances binding of telithromycin (TEL) to A752 in Streptococcus pneumoniae. We have found that another intrinsic methylation of the adjacent uridine at position 747 enhances G748 methylation by RlmA(II), rendering TEL susceptibility. U747 and another nucleotide, U1939, were methylated by the dual-specific methyltransferase RlmCD encoded by SP_1029 in S. pneumoniae. Inactivation of RlmCD reduced N1-methylated level of G748 by RlmA(II) in vivo, leading to TEL resistance when the nucleotide A2058, located in domain V of 23S rRNA, was dimethylated by the dimethyltransferase Erm(B). In vitro methylation of rRNA showed that RlmA(II) activity was significantly enhanced by RlmCD-mediated pre-methylation of 23S rRNA. These results suggest that RlmCD-mediated U747 methylation promotes efficient G748 methylation by RlmA(II), thereby facilitating TEL binding to the ribosome. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

The Tennessee Lottery Scholarship Program: Impact on Retention

ERIC Educational Resources Information Center

Puryear, Carol G.

2009-01-01

This study examined if the Tennessee Education Lottery Scholarship (TELS), which began in 2004, was related to student retention at the six Tennessee Board of Regents four-year institutions. This study investigated the impact of the TELS on student retention at TBR universities and general knowledge regarding retention. Post-facto data were…

Tennessee Education Lottery Scholarship Program Annual Report: Recipient Outcomes through Fall 2012

ERIC Educational Resources Information Center

Tennessee Higher Education Commission, 2013

2013-01-01

The Tennessee Education Lottery Scholarship (TELS) program was designed to meet the unique needs of the state of Tennessee while also incorporating the hallmark elements of existing merit-based aid programs in other states. Developed through a process involving elected officials and members of the academic community, the TELS program aims to…

Implementing a Cost Effectiveness Analyzer for Web-Supported Academic Instruction: A Campus Wide Analysis

ERIC Educational Resources Information Center

Cohen, Anat; Nachmias, Rafi

2009-01-01

This paper describes the implementation of a quantitative cost effectiveness analyzer for Web-supported academic instruction that was developed in Tel Aviv University during a long term study. The paper presents the cost effectiveness analysis of Tel Aviv University campus. Cost and benefit of 3,453 courses were analyzed, exemplifying campus-wide…

The Benefits of Testing for Learning on Later Performance

ERIC Educational Resources Information Center

McConnell, Meghan M.; St-Onge, Christina; Young, Meredith E.

2015-01-01

Testing has been shown to enhance retention of learned information beyond simple studying, a phenomena known as test-enhanced learning (TEL). Research has shown that TEL effects are greater for tests that require the production of responses [e.g., short-answer questions (SAQs)] relative to tests that require the recognition of correct answers…

75 FR 18783 - Middle East Public Health Mission; Application Deadline Extended

Federal Register 2010, 2011, 2012, 2013, 2014

2010-04-13

..., Baltimore U.S. Export Assistance Center, Tel: 410- 962-4518, Fax: 410-962-4529, E-mail: [email protected] . Ms. Lisa C. Huot, U.S. Department of Commerce, Washington, DC 20230, Tel: 202-482-2796, Fax: 202-482-0115, E-Mail: Lisa[email protected] . Sean Timmins, Global Trade Programs, Commercial Service...

An evaluation of UK foundation trainee doctors' learning behaviours in a technology-enhanced learning environment.

PubMed

Brooks, Hannah L; Pontefract, Sarah K; Hodson, James; Blackwell, Nicholas; Hughes, Elizabeth; Marriott, John F; Coleman, Jamie J

2016-05-03

Technology-Enhanced Learning (TEL) can be used to educate Foundation Programme trainee (F1 and F2) doctors. Despite the advantages of TEL, learning behaviours may be exhibited that are not desired by system developers or educators. The aim of this evaluation was to investigate how learner behaviours (e.g. time spent on task) were affected by temporal (e.g. time of year), module (e.g. word count), and individual (e.g. knowledge) factors for 16 mandatory TEL modules related to prescribing and therapeutics. Data were extracted from the SCRIPT e-Learning platform for first year Foundation trainee (F1) doctors in the Health Education England's West Midland region from 1(st) August 2013 to 5(th) August 2014. Generalised Estimating Equation models were used to examine the relationship between time taken to complete modules, date modules were completed, pre- and post-test scores, and module factors. Over the time period examined, 688 F1 doctors interacted with the 16 compulsory modules 10,255 times. The geometric mean time taken to complete a module was 28.9 min (95% Confidence Interval: 28.4-29.5) and 1,075 (10.5%) modules were completed in less than 10 min. In February and June (prior to F1 progression reviews) peaks occurred in the number of modules completed and troughs in the time taken. Most modules were completed, and the greatest amount of time was spent on the learning on a Sunday. More time was taken by those doctors with greater pre-test scores and those with larger improvements in test scores. Foundation trainees are exhibiting unintended learning behaviours in this TEL environment, which may be attributed to several factors. These findings can help guide future developments of this TEL programme and the integration of other TEL programmes into curricula by raising awareness of potential behavioural issues that may arise.

The Development of Technology Enhanced Learning: Findings from a 2008 Survey of UK Higher Education Institutions

ERIC Educational Resources Information Center

Jenkins, Martin; Browne, Tom; Walker, Richard; Hewitt, Roger

2011-01-01

This article summarises the key findings from a UK survey of higher education institutions, focusing on the development of technology enhanced learning (TEL). TEL is defined as any online facility or system that directly supports learning and teaching. The 2008 survey builds upon previous UCISA surveys conducted in 2001, 2003 and 2005 and for…

Local Tax Limits, Student Achievement, and School-Finance Equalization

ERIC Educational Resources Information Center

Davis, Matthew; Vedder, Andrea; Stone, Joe

2016-01-01

Evidence that local tax and expenditure limits (TELs) for public K-12 schools lower student achievement is widely attributed to the effects of reduced funding, but our results cast doubt on reduced funding as the primary explanation for negative effects of TELs and instead suggest the importance of the predictability of funding. Students in…

Reengineering Framework for Systems in Education

ERIC Educational Resources Information Center

Choquet, Christophe; Corbiere, Alain

2006-01-01

Specifications recently proposed as standards in the domain of Technology Enhanced Learning (TEL), question the designers of TEL systems on how to put them into practice. Recent studies in Model Driven Engineering have highlighted the need for a framework which could formalize the use of these specifications as well as enhance the quality of the…

Workshop on III-V Integrated Optoelectronics Held in Hilton Head, South Carolina on 28-30 March 1989

DTIC Science & Technology

1990-01-01

Barney De Loach AT&T Bell Laboratories MH 2D-351 600 Mountain Avenue Murray Hill, NJ 07974 Tel: 201-582-3382 Fax: 201-582-2451 Dr. M.A. Di Giuseppe AT...Park, NC 27709-2211 Tel: 919-549-0641 Fax: 919-549-9399 Professor T. Ken Gustafson Department of Electrical Engineering and Computer Sciences

Beneath Our Eyes: An Exploration of the Relationship between Technology Enhanced Learning and Socio-Ecological Sustainability in Art and Design Higher Education

ERIC Educational Resources Information Center

Sclater, Madeleine

2016-01-01

This article uses published research to explore how Technology Enhanced Learning (TEL) can help to sustain learning communities to engage in creative exploration and open investigation. It then draws on this research to ask: how could we use TEL to support pedagogies of socio-ecological sustainability in the Art and Design education community?…

T cell receptor cross-reactivity directed by antigen-dependent tuning of peptide-MHC molecular flexibility

PubMed Central

Borbulevych, Oleg Y.; Piepenbrink, Kurt H.; Gloor, Brian E.; Scott, Daniel R.; Sommese, Ruth F.; Cole, David K.; Sewell, Andrew K.; Baker, Brian M.

2011-01-01

Summary Tell mediated immunity requires T cell receptor (TCR) cross-reactivity, the mechanisms behind which remain incompletely elucidated. The αβ TCR A6 recognizes both the Tax (LLFGYPVYV) and Tel1p (MLWGYLQYV) peptides presented by the human class I MHC molecule HLA-A2. Here we found that although the two ligands are ideal structural mimics, they form substantially different interfaces with A6, with conformational differences in the peptide, the TCR, and unexpectedly, the MHC molecule. The differences between the Tax and Tel1p ternary complexes could not be predicted from the free peptide-MHC structures and are inconsistent with a traditional induced-fit mechanism. Instead, the differences were attributable to peptide and MHC molecular motion present in Tel1p-HLA-A2 but absent in Tax-HLA-A2. Differential “tuning” of the dynamic properties of HLA-A2 by the Tax and Tel1p peptides thus facilitates cross-recognition and impacts how structural diversity can be presented to and accommodated by receptors of the immune system. PMID:20064447

IUE short-wavelength high-dispersion line list for the symbiotic nova RR Telescopii

NASA Technical Reports Server (NTRS)

Aufdenberg, Jason P.

1993-01-01

An 820 minute and other long-exposure archival SWP IUE high-dispersion spectra of symbiotic star RR Tel have been combined to form a composite spectrum. In most of these spectra many lines are saturated, but weaker features appear above the continuum. Their wavelengths were measured from the composite spectrum and compared with the line list from a thorough study of RR Tel by Penston et al. (1983). Among the revised line list are 22 new line identifications from ions C III, O I, N I, Mg VI, Si I, S I, S IV, Fe II, and Ni II. N I exists inside RR Tel's H II region and is pumped by the hot component's continuum. The fluxes for all the lines in each of the spectra are presented. All of the observed ions show a secular flux decrease between 1978 and 1988. A list of SWP high-dispersion camera artifacts is also presented. The list was generated by comparing RR Tel spectra to a long-exposure sky flat.

Determination of alkyllead compounds by HPLC/ICP using a glass-frit nebulizer ICP interface

NASA Astrophysics Data System (ADS)

Ibrahim, Mona; Nisamaneepong, Wipawan; Haas, David L.; Caruso, Joseph A.

The glass-frit nebulizer, by forming a very fine mist, has improved the ability of the ICP to accept the introduction of organic solvents with high evaporation rates. The reversed-phase chromatographic separation of TML and TEL, and their determination with glass frit nebulization ICP was accomplished with various mobile phases and columns. The separation of several trialkyllead salts also was studied on a strong cation exchange column, but these compounds were not determined with the glass frit nebulizer interface. Detection limits as low as 33 pg s -1 for TML and 100 pg s -1 for TEL and precision of 3.4% for TML and 6.9% relative standard deviation for TEL were obtained.

29 CFR 776.20 - “Goods.”

Code of Federal Regulations, 2011 CFR

2011-07-01

... ingredient thereof, but does not include goods after their delivery into the actual physical possession of... pointed out in Lenroot v. Western Union Tel. Co., 141 F. 2d 400 (C.A. 2), the legislative history shows... amendment. 19 Western Union Tel. Co. v. Lenroot 323 U.S. 490. 20 Mabee v. White Plains Pub. Co., 327 U.S...

Retinal Crystals in Type 2 Idiopathic Macular Telangiectasia

PubMed Central

Sallo, Ferenc B; Leung, Irene; Chung, Mina; Wolf-Schnurrbusch, Ute EK; Dubra, Alfredo; Williams, David R; Clemons, Traci; Pauleikhoff, Daniel; Bird, Alan C; Peto, Tunde

2012-01-01

Purpose To characterize the phenotype and investigate the associations of intraretinal crystalline deposits in a large cohort of Type 2 Idiopathic Macular Telangiectasia (MacTel) Design Case-control study Participants Patients with and without retinal crystals from the Macular Telangiectasia Project, an international multi-centre prospective study of Type 2 MacTel. Methods Grading of stereoscopic 30° colour fundus (CF), confocal blue light reflectance (CBR), red-free (RF) and infrared (IR) images was performed according to the MacTel Natural History Study protocol and staged using the classification system devised by Gass & Blodi. SD-OCT and adaptive optics imaging were used for a finer analysis of the phenotype. Associations between crystals and other characteristics of the disease as well as potential risk factors were investigated. Main outcome measures Presence of crystals, fundus signs of MacTel, clinical characteristics, presence of potential risk factors of MacTel. Results Out of 443 probands enrolled in the MacTel study, 203 (46%) had crystalline deposits present; 60% of the cases were bilateral at baseline. Eyes with crystals had a mean letter score of 70.7 (SD=15.9) while those without crystals had a mean of 66.5 letters (SD=15.5, p<0.001). Crystals were present at all stages of the disease and showed high reflectivity within a wide wavelength range. They were located at the anterior surface of the nerve fibre layer, arranged along the nerve fibres, within an annular area centred on the fovea. Significant associations of crystalline deposits were found with a loss of retinal transparency, MPOD loss, fluorescein leakage, retinal thickness and a break in the IS/OS junction line. Associations with environmental risk factors were not found. Conclusions Intraretinal crystals are a frequent phenomenon associated with type 2 MacTel, they may appear at all stages and may aid in the early diagnosis of the disease. Their morphology further implicates Müller cells

Crew of Hubble Space Telescope servicing mission visits Europe

NASA Astrophysics Data System (ADS)

1994-01-01

The Hubble Space telescope servicing mission in December (STS-61) was a great success and the fully refurbished orbiting telescope produced absolutely remarkable first results just two weeks ago. The 7-member crew who carried out the mission will soon be in Europe to share their experience with the Press, ESA space specialists and the European space community. Public conferences will also be held in Switzerland, the home country of ESA astronaut Claude Nicollier. The visit of the STS-61 crew is scheduled as follows: Friday 11 February, 1994 - ESA Paris, France Presentation and Press Conference Location: ESA, 8/10 Rue Mario Nikis, 75015 Paris time: 16:00 hrs - 17:30 hrs contact: ESA, Public Relations Office Tel. (+33) 1 42 73 71 55 Fax. (+33) 1 42 73 76 90 Monday 14 February, 1994 - British Aerospace, Bristol, United Kingdom Presentation and Press Conference Location: British Aerospace, FPC 333, Filton, Bristol BS12 7QW time: 10:00 hrs - 12:00 hrs contact: BAe, Public Relations Tel. (+44) 272 36 33 69 Tel. (+44) 272 36 33 68 Tuesday 15 February, 1994 - ESA/ESTEC, Noordwijk, the Netherlands Presentation and Press Conference Location: Noordwijk Space Expo, Keplerlaan 3, 2201 AZ Noordwijk, the Netherlands time: 09:30 hrs - 12:00 hrs contact: ESTEC Public Relations Office Tel. (+31) 1719 8 3006 Fax. (+31) 1719 17 400 Wednesday 16 February, 1944 - ESO, Garching - Munich, Germany Presentation and Press Conference Location: European Southern Observatory, Karl- Schwarzschild-Str. 2, 85748 Garching -Munich, Germany time: to be decided contact: ESO Information Service Tel. (+49) 89 32 006 276 Fax. (+49) 89 320 23 62 Thursday 17 February, 1994 - Bern, Switzerland a. Presentation and Press Conference Location: Hotel Bern, Zeughausgasse 9, 3001 Bern, Switzerland time: 09:30 hrs contact: Press & Information Service of the Federal Dept. for Education & Sciences Tel. (+41) 31 322 80 34 Fax. (+41) 31 312 30 15 b. Public conference Location: University of Bern, Institute of Physics

Writing My Way to My Future | Poster

Cancer.gov

By Nathalie Walker, Guest Writer Editor’s note: This article is the second in a series describing one student’s perspective on her experiences as a Werner H. Kirsten student intern. “The future depends on what you do today.” Those wise words were spoken by Mahatma Gandhi. Before I started my Werner H. Kirsten (WHK) student internship, I did not know what I know now. I only knew what each of Gandhi’s words meant individually. I now understand the full meaning of the phrase. To me, Gandhi’s words mean that nothing in life is handed to you. You have to work hard today to get the results you want tomorrow.

A study of cryogenic tissue-engineered liver slices in calcium alginate gel for drug testing.

PubMed

Chen, Ruomeng; Wang, Bo; Liu, Yaxiong; Lin, Rong; He, Jiankang; Li, Dichen

2018-06-01

To address issues such as transportation and the time-consuming nature of tissue-engineered liver for use as an effective drug metabolism and toxicity testing model, "ready-to-use" cryogenic tissue-engineered liver needs to be studied. The research developed a cryogenic tissue-engineered liver slice (TELS), which comprised of HepG2 cells and calcium alginate gel. Cell viability and liver-specific functions were examined after different cryopreservation and recovery culture times. Then, cryogenic TELSs were used as a drug-testing model and treated with Gefitinib. Cryogenic TELSs were stored at -80 °C to ensure high cell viability. During recovery in culture, the cells in the cryogenic TELS were evenly distributed, massively proliferated, and then formed spheroid-like aggregates from day 1 to day 13. The liver-specific functions in the cryogenic TELS were closely related to cryopreservation time and cell proliferation. As a reproducible drug-testing model, the cryogenic TELS showed an obvious drug reaction after treatment with the Gefitinib. The present study shows that the cryopreservation techniques can be used in drug-testing models. Copyright © 2018 Elsevier Inc. All rights reserved.

Inhibition of telomerase recruitment and cancer cell death.

PubMed

Nakashima, Mai; Nandakumar, Jayakrishnan; Sullivan, Kelly D; Espinosa, Joaquín M; Cech, Thomas R

2013-11-15

Continued proliferation of human cells requires maintenance of telomere length, usually accomplished by telomerase. Telomerase is recruited to chromosome ends by interaction with a patch of amino acids (the TEL patch, for TPP1 glutamate (E) and leucine (L)-rich patch) on the surface of telomere protein TPP1. In previous studies, interruption of this interaction by mutation prevented telomere extension in HeLa cells, but the cell culture continued to grow. We now show that the telomerase inhibitor BIBR1532 acts together with TEL patch mutations to inhibit the growth of HeLa cell lines and that apoptosis is a prominent mechanism of death of these cells. Survivor cells take over the population beginning around 40 days in culture. These cells no longer express the TEL patch mutant TPP1, apparently because of silencing of the expression cassette, a survival mechanism that would not be available to cancer cells. These results provide hope that inhibiting the binding of telomerase to the TEL patch of TPP1, perhaps together with a modest inhibition of the telomerase enzyme, could comprise an effective anticancer therapy for the ∼90% of human tumors that are telomerase-positive.

Carbon dioxide (CO2) laser third eyelid excision: surgical description and report of 7 cases.

PubMed

Dees, Dustin D; Knollinger, Amy M; MacLaren, Nicole E

2015-09-01

To describe a novel technique for third eyelid (TEL) excision using a carbon dioxide (CO2) laser. Prospective. The procedure was performed on six canine patients and one feline patient. The laser was set to 6 Watts (W) of power and a linear continuous setting. Forceps were used to elevate the TEL and, with a protective shield covering the cornea, the base was cut and cauterized simultaneously. Minimal to no hemorrhage was observed, and the conjunctiva was left to heal by second intention. Seven patients underwent unilateral surgical TEL excision. All patients had suspected neoplasms affecting either the glandular tissues or conjunctival surfaces of the TEL. Clean surgical margins were achieved in all but one patient. All surgical sites were considered healed by 14 days showing mild-to-moderate conjunctival hyperemia and accumulation of mucoid discharge at the ventronasal fornix. One patient experienced postoperative keratoconjunctivitis sicca. Prolapse of orbital fat was not observed in any patient. Use of CO2 laser appears to be an efficient and effective means for surgical third eyelid removal with excellent postoperative comfort and minimal complications. © 2014 American College of Veterinary Ophthalmologists.

Human parvovirus B19 in childhood acute lymphoblastic leukaemia in Basrah.

PubMed

Ibrahem, Wijdan Nazar; Hasony, Hassan Jaber; Hassan, Jenan Ghulam

2014-01-01

To investigate the association of human parvovirus B19 infection with the onset of acute lymphoblastic leukaemia and its effect on TEL-AML-1 fusion gene and the presence of mutant P53. The case-control study was conducted at Basrah Hospital for Paediatrics and Gynaecology, Basrah, Iraq, from May 2009 to April 2010. A total of 100 blood samples were collected from 40 newly diagnosed cases and 60 healthy children to serve as control matched by age and gender. Human parvovirus B19-IgG and anti-P53 antibody were detected by enzyme-linked immunosorbent assay and TEL-AML-1 fusion gene was detected by reverse transcriptase-polymerase chain reaction on extracted ribonucleic acid from fresh blood samples using specified primers. SPSS 15 was used for statistical analysis. A higher proportion of human parvovirus B19-positive cases was found in leukaemic patients (n=19; 47.5%) compared to 12 (20%) in the control group (p<0.05). There was significant association between TEL-AML-1 translocation and human parvovirus-B19 infection as 10 (71.4%) of TEL-AML-1 translocation-positive cases had human parvovirus-B19 IgG. On the other hand, there was no association between such infections and P53 gene mutation in the patients. Human parvovirus-B19 infection is common in the population, with higher prevalence among leukaemic patients with significant association between human parvovirus-B19 and TEL-AML-1 fusion gene in patients of acute lymphoblastic leukaemia.

Fundamental Study of Antimonide Nanostructures by Molecular Beam Epitaxy

DTIC Science & Technology

2016-02-04

Faculty of Engineering, Chulalongkorn University, Phayathai Road, Bangkok 10330, Thailand Tel. (+66) 2218-6524, Fax. (+66) 2218-6523 E-mail...Engineering Department Faculty of Engineering Chulalongkorn University, Phayathai Road, Bangkok 10330, Thailand Tel. 662-218-6524, Fax. 662-218-6523...September 2014 to July 2015 being conducted at Chulalongkorn University in Thailand . Following the research work on InAs quantum dots (QDs) and quantum

Studying the Immunomodulatory Effects of Small Molecule Ras-Inhibitors in Animal Models of Rheumatoid Arthritis

DTIC Science & Technology

2015-10-01

Models of Rheumatoid Arthritis PRINCIPAL INVESTIGATOR: Yoel Kloog RECIPIENT: Tel Aviv University TEL AVIV 69978 Israel REPORT DATE: October...TITLE AND SUBTITLE Studying the Immunomodulatory Effects of Small Molecule Ras- Inhibitors in Animal Models of Rheumatoid Arthritis 5a. CONTRACT NUMBER... Rheumatoid Arthritis (RA) display augmented activation of the Ras/Raf/MEK/ERK1/2 signaling pathway, and accordingly overexpression of active K-RAS in

The effect of an interactive weekly mobile phone messaging on retention in prevention of mother to child transmission (PMTCT) of HIV program: study protocol for a randomized controlled trial (WELTEL PMTCT).

PubMed

Awiti, Patricia Opondo; Grotta, Alessandra; van der Kop, Mia; Dusabe, John; Thorson, Anna; Mwangi, Jonathan; Belloco, Rino; Lester, Richard; Ternent, Laura; Were, Edwin; Ekström, Anna Mia

2016-07-11

Improving retention in prevention of mother to child transmission (PMTCT) of HIV programs is critical to optimize maternal and infant health outcomes, especially now that lifelong treatment is immediate regardless of CD4 cell count). The WelTel strategy of using weekly short message service (SMS) to engage patients in care in Kenya, where mobile coverage even in poor areas is widespread has been shown to improve adherence to antiretroviral therapy (ART) and viral load suppression among those on ART. The aim of this study is to determine the effect of the WelTel SMS intervention compared to standard care on retention in PMTCT program in Kenya. WelTel PMTCT is a four to seven-centers, two-arm open randomized controlled trial (RCT) that will be conducted in urban and rural Kenya. Over 36 months, we plan to recruit 600 pregnant women at their first antenatal care visit and follow the mother-infant pair until they are discharged from the PMTCT program (when infant is aged 24 months). Participants will be randomly allocated to the intervention or control arm (standard care) at a 1:1 ratio. Intervention arm participants will receive an interactive weekly SMS 'How are you?' to which they are supposed to respond within 24 h. Depending on the response (ok, problem or no answer), a PMTCT nurse will follow-up and triage any problems that are identified. The primary outcome will be retention in care defined as the proportion of mother-infant pairs coming for infant HIV testing at 24 months from delivery. Secondary outcomes include a) adherence to WelTel; (b) adherence to antiretroviral medicine; (c) acceptance of WelTel and (d) cost-effectiveness of the WelTel intervention. This trial will provide evidence on the effectiveness of mHealth for PMTCT retention. Trial results and the cost-effectiveness evaluation will be used to inform policy and potential scale-up of mHealth among mothers living with HIV. ISRCTN98818734 ; registered on 9th December 2014.

Benchmark cool companions: ages and abundances for the PZ Telescopii system

NASA Astrophysics Data System (ADS)

Jenkins, J. S.; Pavlenko, Y. V.; Ivanyuk, O.; Gallardo, J.; Jones, M. I.; Day-Jones, A. C.; Jones, H. R. A.; Ruiz, M. T.; Pinfield, D. J.; Yakovina, L.

2012-03-01

We present new ages and abundance measurements for the pre-main-sequence star PZ Telescopii (more commonly known as PZ Tel). PZ Tel was recently found to host a young and low-mass companion. Such companions, whether they are brown dwarfs or planetary systems, can attain benchmark status by detailed study of the properties of the primary, and then evolutionary and bulk characteristics can be inferred for the companion. Using Fibre-fed Extended Range Optical Spectrograph spectra, we have measured atomic abundances (e.g. Fe and Li) and chromospheric activity for PZ Tel and used these to obtain the metallicity and age estimates for the companion. We have also determined the age independently using the latest evolutionary models. We find PZ Tel A to be a rapidly rotating (v sin i= 73 ± 5 km s-1), approximately solar metallicity star [log N(Fe) =-4.37 ± 0.06 dex or [Fe/H] = 0.05 ± 0.20 dex]. We measure a non-local thermodynamic equilibrium lithium abundance of log N(Li) = 3.1 ± 0.1 dex, which from depletion models gives rise to an age of 7? Myr for the system. Our measured chromospheric activity (? of -4.12) returns an age of 26 ± 2 Myr, as does fitting pre-main-sequence evolutionary tracks (τevol= 22 ± 3 Myr), both of these are in disagreement with the lithium age. We speculate on reasons for this difference and introduce new models for lithium depletion that incorporate both rotation and magnetic field effects. We also synthesize solar, metal-poor and metal-rich substellar evolutionary models to better determine the bulk properties of PZ Tel B, showing that PZ Tel B is probably more massive than previous estimates, meaning the companion is not a giant exoplanet, even though a planetary-like formation origin can go some way to describing the distribution of benchmark binaries currently known. We show how PZ Tel B compares to other currently known age and metallicity benchmark systems and try to empirically test the effects of dust opacity as a function of

Orbital fitting of imaged planetary companions with high eccentricities and unbound orbits. Their application to Fomalhaut b and PZ Telecopii B

NASA Astrophysics Data System (ADS)

Beust, H.; Bonnefoy, M.; Maire, A.-L.; Ehrenreich, D.; Lagrange, A.-M.; Chauvin, G.

2016-03-01

Context. Regular follow-up of imaged companions to main-sequence stars often allows a projected orbital motion to be detected. Markov chain Monte Carlo (MCMC) has become very popular recent years for fitting and constraining their orbits. Some of these imaged companions appear to move on very eccentric, possibly unbound orbits. This is, in particular, the case for the exoplanet Fomalhaut b and the brown dwarf companion PZ Tel B on which we focus here. Aims: For these orbits, standard MCMC codes that assume only bound orbits may be inappropriate. Our goal is to develop a new MCMC implementation that is able to handle both bound and unbound orbits in a continuous manner, and to apply this to the cases of Fomalhaut b and PZ Tel B. Methods: We present here this code, based on the use of universal Keplerian variables and Stumpff functions. We present two versions of this code, the second one using a different set of angular variables that were designed to avoid degeneracies arising when the projected orbital motion is quasi-radial, as is the case for PZ Tel B. We also present additional observations of PZ Tel B. Results: The code is applied to Fomalhaut b and PZ Tel B. We confirm previous results in relation to, but we show that on the sole basis of the astrometric data, open orbital solutions are also possible. The eccentricity distribution nevertheless still peaks around ~0.9 in the bound regime. We present a first successful orbital fit of PZ Tel B, which shows in particular that, while both bound and unbound orbital solutions are equally possible, the eccentricity distribution presents a sharp peak very close to e = 1, meaning a quasi-parabolic orbit. Conclusions: It has recently been suggested that the presence of unseen inner companions to imaged ones may lead orbital fitting algorithms to artificially give very high eccentricities. We show that this caveat is unlikely to apply to Fomalhaut b. Concerning PZ Tel B, we derive a possible solution, which involves an

OCT Angiography Helps Distinguish Between Proliferative Macular Telangiectasia Type 2 and Neovascular Age-Related Macular Degeneration.

PubMed

Zheng, Fang; Motulsky, Elie H; de Oliveira Dias, João Rafael; de López, Edith Pérez; Gregori, Giovanni; Rosenfeld, Philip J

2018-05-01

To demonstrate the advantage of optical coherence tomography angiography (OCTA) for the diagnosis and management of proliferative macular telangiectasia type 2 (MacTel2) masquerading as neovascular age-related macular degeneration (AMD). This is an observational cases series. Three patients referred with the diagnosis of neovascular AMD were identified in this retrospective study. In addition to color fundus, fluorescein angiography, and spectral-domain OCT (SD-OCT) imaging, SD-OCTA (AngioPlex; Carl Zeiss Meditec, Dublin, CA) was performed. SD-OCTA revealed bilateral parafoveal retinal microvascular changes in three patients and unambiguously confirmed the diagnosis of MacTel2. OCTA is an important tool for the correct diagnosis of MacTel2 in older patients with the concomitant or masquerading diagnosis of AMD. [Ophthalmic Surg Lasers Imaging Retina. 2018;49:303-312.]. Copyright 2018, SLACK Incorporated.

Adaptability in Coalition Teamwork: Leader and Team Adaptability in Multi-National Coalitions (LTAMC) (Adaptabilite dans le travail d’equipe en Coalition: Adaptabilite des chefs et des equipes dans les coalitions multinationales)

DTIC Science & Technology

2012-11-01

Bldg. 33 Wright- Patterson AFB, OH 45433 Email: janet.sutton@wpafb.af.mil xviii RTO-TR-HFM-138 RTO-TR-HFM-138 ES - 1 Adaptability in...711 Human Performance Wing/Human Effectiveness, Cognitive Systems Branch Wright- Patterson AFB, OH 45433 USA Tel: 1+ 937.656.4316 Fax: 1...AFRL) 711 Human Performance Wing/Human Effectiveness, Cognitive Systems Branch Wright- Patterson AFB, OH 45433 USA Tel: 1+ 937.785.3165 Fax: 1

Ten-year experiences on initial genetic examination in childhood acute lymphoblastic leukaemia in Hungary (1993-2002). Technical approaches and clinical implementation.

PubMed

Olah, Eva; Balogh, Erzsebet; Pajor, Laszlo; Jakab, Zsuzsanna

2011-03-01

A nationwide study was started in 1993 to provide genetic diagnosis for all newly diagnosed childhood ALL cases in Hungary using cytogenetic examination, DNA-index determination, FISH (aneuploidy, ABL/BCR, TEL/AML1) and molecular genetic tests (ABL/BCR, MLL/AF4, TEL/AML1). Aim of the study was to assess the usefulness of different genetic methods, to study the frequency of various aberrations and their prognostic significance. Results were synthesized for genetic subgrouping of patients. To assess the prognostic value of genetic aberrations overall and event-free survival of genetic subgroups were compared using Kaplan-Meier method. Prognostic role of aberrations was investigated by multivariate analysis (Cox's regression) as well in comparison with other factors (age, sex, major congenital abnormalities, initial WBC, therapy, immunophenotype). Five hundred eighty-eight ALL cases were diagnosed between 1993-2002. Cytogenetic examination was performed in 537 (91%) (success rate 73%), DNA-index in 265 (45%), FISH in 74 (13%), TEL/AML1 RT-PCR in 219 (37%) cases producing genetic diagnosis in 457 patients (78%). Proportion of subgroups with good prognosis in prae-B-cell ALL was lower than expected: hyperdiploidB 18% (73/400), TEL/AML1+ 9% (36/400). Univariate analysis showed significantly better 5-year EFS in TEL/AML1+ (82%) and hyperdiploidB cases (78%) than in tetraploid (44%) or pseudodiploid (52%) subgroups. By multivariate analysis main negative prognostic factors were: congenital abnormalities, high WBC, delay in therapy, specific translocations. Complementary use of each of genetic methods used is necessary for reliable genetic diagnosis according to the algorithm presented. Specific genetic alterations proved to be of prognostic significance.

Adaptive Learning in Medical Education: The Final Piece of Technology Enhanced Learning?

PubMed

Sharma, Neel; Doherty, Iain; Dong, Chaoyan

2017-09-01

Technology enhanced learning (TEL) is now common practice in the field of medical education. One of the primary examples of its use is that of high fidelity simulation and computerised mannequins. Further examples include online learning modules, electronic portfolios, virtual patient interactions, massive open online courses and the flipped classroom movement. The rise of TEL has occurred primarily due to the ease of internet access enabling the retrieval and sharing of information in an instant. Furthermore, the compact nature of internet ready devices such as smartphones and laptops has meant that access to information can occur anytime and anywhere. From an educational perspective however, the current utilisation of TEL has been hindered by its lack of understanding of learners' needs. This is concerning, particularly as evidence highlights that during medical training, each individual learner has their own learning requirements and often achieves competency at different rates. In view of this, there has been interest in ensuring TEL is more learner aware and that the learning process should be more personalised. Adaptive learning can aim to achieve this by ensuring content is delivered according to the needs of the learner. This commentary highlights the move towards adaptive learning and the benefits of such an intervention.

Dynamic Geochemistry of Tetraethyl Lead Dust during the 20th Century: Getting the Lead In, Out, and Translational Beyond

PubMed Central

2018-01-01

This commentary provides a brief overview of policy decisions that permitted getting tetraethyl lead (TEL) into petrol; global geochemical lead-dust deposition evidence; 1975 catalytic converter requirements; concern about habitability of cities; a personal perspective on legacy lead research that accelerated getting TEL out of petrol; and translational beyond, including New Orleans pre- vs. post-Hurricane Katrina observations about legacy lead interventions that effectively improve urban children’s health outcomes. PMID:29701636

Advanced Computational Models for Fabric-Reinforced Composites

DTIC Science & Technology

2001-10-01

composites. Trans-Science Corporation 3655 Nobel Drive Suite 440 San Diego, CA 92122-1005 Tel (858) 459-1240 http://www.compositesolutionsinc.com...also based in XP! Material Suppliers San Diego, recently developed the only Newsletters comprehensive design software for the seismic NDT, NDE , NDI...composite bus. Trans-Science Corporation 3655 Nobel Drive Suite 440 San Diego, CA 92122-1005 Tel (858) 459-1240 Fax (858) 459-0210 •’(S-HOME SERVICES

Field Applications of In Situ Remediation Technologies: Permeable Reactive Barriers

DTIC Science & Technology

2002-01-01

dweymann@ emconinc.com Caldwell Trucking Northern NJ 1998 TCE Hydraulic Fracturing , $1.12 M Fe0 Only 60% John Vidumsky Permeation Infilling...Oriented $1.15 M Granular No problems except Stephen H. Shoemaker Chloroform, Freon 11, Hydraulic Fracturing cast iron at recovering an Tel: 704-362...VC Massachusetts Falmouth, MA 1998 PCE, TCE Hydraulic Fracturing $160 K Fe0 Robert W. Gillham Military Reservation Tel: 519-888-4658 CS-10 Plume Fax

Size Distribution, Chemical Composition and Optical Properties of Atmospheric Dust in Israel: A Comparison of Urban and Desert Aerosols under Clear and Dusty Conditions.

DTIC Science & Technology

1980-02-01

size distribution and aerosol particle concentrations during a winter period in Mitzpe Ramon. Negev desert. Fig. 5 Comparison of normalized frequency...Israel. The upper two samples are from Mitzpe Ramon in the Negev desert. The bottom three are from Tel Aviv. The lighter of the three Tel Aviv samples (the...shown show much higher imaginary indices than do those from the Negev desert or the two American desert localities (Lindberg et al., 1976). Fig. 12

Anion-Driven Self-Assembly Processes Based on Halogen-Bonding

DTIC Science & Technology

2007-07-10

23993041 Fax: +39-02-23993180 E-mail: pierangelo.metrangolo@polimi.it Sede Leonardo : Piazza L.Da Vinci , 32 – 20133 Milano Tel. ++39-02...02-23993180 E-mail: pierangelo.metrangolo@polimi.it Sede Leonardo : Piazza L.Da Vinci , 32 – 20133 Milano Tel. ++39-02 2399.3200 Fax ++39-02...Pierangelo Metrangolo Ph. +39-02-23993041 Fax: +39-02-23993180 E-mail: pierangelo.metrangolo@polimi.it Sede Leonardo : Piazza L.Da Vinci , 32

Development of a Combination Therapy for Prostate Cancer by Targeting Stat3 and HIF-1alpha

DTIC Science & Technology

2013-07-01

inflammation-induced cancer, making it an attractive target (25-27). A3. Innovation 1. TEL03 is a novel anti-cancer agent from Chinese herbal medicine ...agents from Chinese herbal medicine (CHM) that targets HIF-1α /2α for prostate cancer therapy. Hypoxia orchestrated by HIF-1αis crucial for tumor...Stat3 for treatment of prostate and other cancers. TEL03, which is a novel anti-cancer agent derived from Chinese herbal medicine (CHM: Hypocrella

JPRS Report, Near East & South Asia

DTIC Science & Technology

1990-11-28

REGIONAL AFFAIRS King Husayn’s Control Over Islamic Factions Questioned tal411182a Tel Aviv HADASHOT in Hebrew 14 Nov 90 p 2 [Text] Yesterday...kingdom. PALESTINIAN AFFAIRS Removal of Israeli Authority Said to Be Goal 91AE0018B Tel Aviv HADASHOT (Weekend Supplement) in Hebrew 7 Sep 90 p 12...holy places and become excited like a romantic virgin upon hearing the names of places from the Bible . You do not really understand this, because

Effects of a TELephone Counselling Intervention by Pharmacist (TelCIP) on medication adherence, patient beliefs and satisfaction with information for patients starting treatment: study protocol for a cluster randomized controlled trial

PubMed Central

2014-01-01

Background Adherence to medication is often low. Pharmacists may improve adherence, but a one-size-fits-all approach will not work: different patients have different needs. Goal of the current study is to assess the effectiveness of a patient-tailored, telephone-based intervention by a pharmacist at the start of pharmacotherapy aimed at improving medication adherence, satisfaction with information and counselling and the beliefs about medicines. Methods/Design A cluster randomized controlled intervention trial in 30 Dutch pharmacies, randomly assigned to 1 of 2 intervention groups. Each group consists of an intervention arm and an usual care arm. The intervention arm in the first group is the usual care arm in the second group and vice versa. One intervention arm focuses on patients starting with antidepressants or bisphosphonates and the other on antilipaemic drugs or renin angiotensin system (RAS)-inhibitors. The intervention consists of a telephone call by a pharmacist 2 or 3 weeks after a new prescription. A random sample of pharmacies will send questionnaires 3 months after the first prescription. This contains socio-demographic questions, a measure of beliefs about medicines (BMQ), satisfaction with information received (SIMS, abbreviated) and frequency of pharmacy counselling (Consumer Quality Index, CQI, abbreviated). The primary outcome measure will be medication adherence calculated from dispensing records retrieved 12 months after the intervention. Patients’ beliefs on medication, perception of the quality of information received and pharmacy counselling are secondary outcomes. Discussion The TelCIP study will determine the effectiveness of telephone counselling to improve adherence in patients initiating a new treatment. By measuring satisfaction with information and counselling and beliefs about medication the study will also give clues for the reason of a potential increase in adherence. Finally the study will provide information on which

Swept Source OCT Angiography of Neovascular Macular Telangiectasia Type 2

PubMed Central

Zhang, Qinqin; Wang, Ruikang K.; Chen, Chieh-Li; Legarreta, Andrew D.; Durbin, Mary K.; An, Lin; Sharma, Utkarsh; Stetson, Paul F.; Legarreta, John E.; Roisman, Luiz; Gregori, Giovanni; Rosenfeld, Philip J.

2015-01-01

Objective To image subretinal neovascularization in proliferative macular telangiectasia type 2 (MacTel2) using swept source optical coherence tomography based microangiography (OMAG). Study Design Patients with MacTel2 were enrolled in a prospective, observational study known as the MacTel Project and evaluated using a high-speed 1050nm swept-source OCT (SS-OCT) prototype system. The OMAG algorithm generated en face flow images from three retinal layers, as well as the region bounded by the outer retina and Bruch’s membrane, the choriocapillaris, and the remaining choroidal vasculature. The en face OMAG images were compared to images from fluorescein angiography (FA) and indocyanine green angiography (ICGA). Results Three eyes with neovascular MacTel2 were imaged. The neovascularization was best identified from the en face OMAG images that included a layer between the outer retinal boundary and Bruch’s membrane. OMAG images identified these abnormal vessels better than FA and were comparable to the images obtained using ICGA. In all three cases, OMAG identified choroidal vessels communicating with the neovascularization, and these choroidal vessels were evident in the two cases with ICGA imaging. In one case, monthly injections of bevacizumab reduced the microvascular complexity of the neovascularization, as well as the telangiectatic changes within the retinal microvasculature. In another case, less frequent bevacizumab therapy was associated with growth of the subretinal neovascular complex. Conclusions OMAG imaging provided detailed, depth-resolved information about subretinal neovascularization in MacTel2 eyes demonstrating superiority to FA imaging and similarities to ICGA imaging for documenting the retinal microvascular changes, the size and extent of the neovascular complex, the communications between the neovascular complex and the choroidal circulation, and the response to monthly bevacizumab therapy. PMID:26457402

Radical-induced purine lesion formation is dependent on DNA helical topology.

PubMed

Terzidis, Michael A; Prisecaru, Andreea; Molphy, Zara; Barron, Niall; Randazzo, Antonio; Dumont, Elise; Krokidis, Marios G; Kellett, Andrew; Chatgilialoglu, Chryssostomos

2016-11-01

Herein we report the quantification of purine lesions arising from gamma-radiation sourced hydroxyl radicals (HO • ) on tertiary dsDNA helical forms of supercoiled (SC), open circular (OC), and linear (L) conformation, along with single-stranded folded and non-folded sequences of guanine-rich DNA in selected G-quadruplex structures. We identify that DNA helical topology and folding plays major, and unexpected, roles in the formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dG) and 8-oxo-7,8-dihydro-2'-deoxyadenosine (8-oxo-dA), along with tandem-type purine lesions 5',8-cyclo-2'-deoxyguanosine (5',8-cdG) and 5',8-cyclo-2'-deoxyadenosine (5',8-cdA). SC, OC, and L dsDNA conformers together with folded and non-folded G-quadruplexes d[TGGGGT] 4 (TG4T), d[AGGG(TTAGGG) 3 ] (Tel22), and the mutated tel24 d[TTGGG(TTAGGG) 3 A] (mutTel24) were exposed to HO • radicals and purine lesions were then quantified via stable isotope dilution LC-MS/MS analysis. Purine oxidation in dsDNA follows L > OC ≫ SC indicating greater damage towards the extended B-DNA topology. Conversely, G-quadruplex sequences were significantly more resistant toward purine oxidation in their unfolded states as compared with G-tetrad folded topologies; this effect is confirmed upon comparative analysis of Tel22 (∼50% solution folded) and mutTel24 (∼90% solution folded). In an effort to identify the accessibly of hydroxyl radicals to quadruplex purine nucleobases, G-quadruplex solvent cavities were then modeled at 1.33 Å with evidence suggesting that folded G-tetrads may act as potential oxidant traps to protect against chromosomal DNA damage.

Caffeine impairs resection during DNA break repair by reducing the levels of nucleases Sae2 and Dna2

PubMed Central

Tsabar, Michael; Eapen, Vinay V.; Mason, Jennifer M.; Memisoglu, Gonen; Waterman, David P.; Long, Marcus J.; Bishop, Douglas K.; Haber, James E.

2015-01-01

In response to chromosomal double-strand breaks (DSBs), eukaryotic cells activate the DNA damage checkpoint, which is orchestrated by the PI3 kinase-like protein kinases ATR and ATM (Mec1 and Tel1 in budding yeast). Following DSB formation, Mec1 and Tel1 phosphorylate histone H2A on serine 129 (known as γ-H2AX). We used caffeine to inhibit the checkpoint kinases after DSB induction. We show that prolonged phosphorylation of H2A-S129 does not require continuous Mec1 and Tel1 activity. Unexpectedly, caffeine treatment impaired homologous recombination by inhibiting 5′ to 3′ end resection, independent of Mec1 and Tel1 inhibition. Caffeine treatment led to the rapid loss, by proteasomal degradation, of both Sae2, a nuclease that plays a role in early steps of resection, and Dna2, a nuclease that facilitates one of two extensive resection pathways. Sae2's instability is evident in the absence of DNA damage. A similar loss is seen when protein synthesis is inhibited by cycloheximide. Caffeine treatment had similar effects on irradiated HeLa cells, blocking the formation of RPA and Rad51 foci that depend on 5′ to 3′ resection of broken chromosome ends. Our findings provide insight toward the use of caffeine as a DNA damage-sensitizing agent in cancer cells. PMID:26019182

Structural basis of sodium–potassium exchange of a human telomeric DNA quadruplex without topological conversion

PubMed Central

Wang, Zi-Fu; Li, Ming-Hao; Hsu, Shang-Te Danny; Chang, Ta-Chau

2014-01-01

Understanding the mechanism of Na+/K+-dependent spectral conversion of human telomeric G-quadruplex (G4) sequences has been limited not only because of the structural polymorphism but also the lack of sufficient structural information at different stages along the conversion process for one given oligonucleotide. In this work, we have determined the topology of the Na+ form of Tel23 G4, which is the same hybrid form as the K+ form of Tel23 G4 despite the distinct spectral patterns in their respective nuclear magnetic resonance (NMR) and circular dichroism spectra. The spectral difference, particularly the well-resolved imino proton NMR signals, allows us to monitor the structural conversion from Na+ form to K+ form during Na+/K+ exchange. Time-resolved NMR experiments of hydrogen–deuterium exchange and hybridization clearly exclude involvement of the global unfolding for the fast Na+/K+ spectral conversion. In addition, the K+ titration monitored by NMR reveals that the Na+/K+ exchange in Tel23 G4 is a two-step process. The addition of K+ significantly stabilizes the unfolding kinetics of Tel23 G4. These results offer a possible explanation of rapid spectral conversion of Na+/K+ exchange and insight into the mechanism of Na+/K+ structural conversion in human telomeric G4s. PMID:24476914

Roles of the checkpoint sensor clamp Rad9-Rad1-Hus1 (911)-complex and the clamp loaders Rad17-RFC and Ctf18-RFC in Schizosaccharomyces pombe telomere maintenance.

PubMed

Khair, Lyne; Chang, Ya-Ting; Subramanian, Lakxmi; Russell, Paul; Nakamura, Toru M

2010-06-01

While telomeres must provide mechanisms to prevent DNA repair and DNA damage checkpoint factors from fusing chromosome ends and causing permanent cell cycle arrest, these factors associate with functional telomeres and play critical roles in the maintenance of telomeres. Previous studies have established that Tel1 (ATM) and Rad3 (ATR) kinases play redundant but essential roles for telomere maintenance in fission yeast. In addition, the Rad9-Rad1-Hus1 (911) and Rad17-RFC complexes work downstream of Rad3 (ATR) in fission yeast telomere maintenance. Here, we investigated how 911, Rad17-RFC and another RFC-like complex Ctf18-RFC contribute to telomere maintenance in fission yeast cells lacking Tel1 and carrying a novel hypomorphic allele of rad3 (DBD-rad3), generated by the fusion between the DNA binding domain (DBD) of the fission yeast telomere capping protein Pot1 and Rad3. Our investigations have uncovered a surprising redundancy for Rad9 and Hus1 in allowing Rad1 to contribute to telomere maintenance in DBD-rad3 tel1 cells. In addition, we found that Rad17-RFC and Ctf18-RFC carry out redundant telomere maintenance functions in DBD-rad3 tel1 cells. Since checkpoint sensor proteins are highly conserved, genetic redundancies uncovered here may be relevant to telomere maintenance and detection of DNA damage in other eukaryotes.

Otoman encounters with European science: sixtienth and seventeenth-century translations into turkish

NASA Astrophysics Data System (ADS)

Gunegrun, Feza

The article concerns the traslation of medical and geographical texts from Arabic, Persian and European languages during Middle Age. The following astonomical texts are mentioned: a)Si fasl der marifet-i takvim (The thirty Chapters of Calendar Making) b)Er- Risaletu'l-fethiyye fi'l- hey'e (Astronomical treatise glorifying the Triump) by Ali Qushji, translated bySeydi Ali Reis c)The European astronomical Tables by Nathalis Durret (1590-1650)translated by Tezkireci Kose Ibrahim (1635-1663) d)Secenel-al-aflak fi gayet al idrak (Mirror of the Heavens and the Summit of Perception)translated by Tezkireci Kose Ibrahim Effendi. It is noted, that Ottoman astrologers and timekeepers used the tables by Ulug Beg till the mid- eighteenth century. e) The astronomical tables by Alexis Clairot (1713-165) were translated by Helifezade Cinari Ismail Effendi.

Nonequilibrium transport of charge carriers and transient electroluminescence in organic light-emitting diodes

NASA Astrophysics Data System (ADS)

Nikitenko, V. R.; von Seggern, H.

2007-11-01

An analytic theory of nonequilibrium hopping charge transport in disordered organic materials includes quasiequilibrium (normal) and extremely nonequilibrium (dispersive) regimes as limiting cases at long and short times, respectively. In the intermediate interval of time quasiequilibrium value of mobility is nearly established while the coefficient of field-assisted diffusion continues to increase (quasidispersive regime). Therefore, normalized time dependencies of transient current in time-of-flight (TOF) conditions are practically independent of field strength and sample thickness, in good agreement both with data of TOF experiments for molecularly doped polymers and results of numerical simulations of Gaussian disorder model. An analytic model of transient electroluminescence (TEL) is developed on the base of the mentioned theory. Strong asymmetry of mobilities is presumed. In analogy with TOF transients, dispersion parameter of normalized TEL intensity is anomalously large and almost field independent in the quasidispersive regime of transport. The method for determination of mobility from TEL data is proposed.

An Enzyme-Catalyzed Multistep DNA Refolding Mechanism in Hairpin Telomere Formation

PubMed Central

Shi, Ke; Huang, Wai Mun; Aihara, Hideki

2013-01-01

Hairpin telomeres of bacterial linear chromosomes are generated by a DNA cutting–rejoining enzyme protelomerase. Protelomerase resolves a concatenated dimer of chromosomes as the last step of chromosome replication, converting a palindromic DNA sequence at the junctions between chromosomes into covalently closed hairpins. The mechanism by which protelomerase transforms a duplex DNA substrate into the hairpin telomeres remains largely unknown. We report here a series of crystal structures of the protelomerase TelA bound to DNA that represent distinct stages along the reaction pathway. The structures suggest that TelA converts a linear duplex substrate into hairpin turns via a transient strand-refolding intermediate that involves DNA-base flipping and wobble base-pairs. The extremely compact di-nucleotide hairpin structure of the product is fully stabilized by TelA prior to strand ligation, which drives the reaction to completion. The enzyme-catalyzed, multistep strand refolding is a novel mechanism in DNA rearrangement reactions. PMID:23382649

JPRS Report, Near East & South Asia

DTIC Science & Technology

1990-11-08

INTERNATIONAL AFFAIRS Undeclared Strategic Agendas in Gulf 91AE0085A Tel Aviv YEDI’OT AHARONOT in Hebrew 30 Oct 90 pp 7, 25 [Article by Ron Ben...faithful representative of the " bible belt" in the southern United States. It is currently difficult to know who initiated the Saudi deals. Was it the...state. JPRS-NEA-90-066 8 NOVEMBER 1990 NEAR EAST 13 ISRAEL Columnist Examines U.S. Middle East Policy 91AE0038B Tel Aviv MA’ARIV in Hebrew

JPRS Report Near East & South Asia

DTIC Science & Technology

1991-03-14

represent the wishes of the Iraqi people. ISRAEL Poll on Territorial Compromise Option Published TA1131501A Tel Aviv YEDI’OT AHARONOT in Hebrew 8...percent Habad Promises To Return Soviet Children TA2122157A Jerusalem Israel Television Network in Hebrew 1900 GMT 21 Feb 91 [Text] The heads of...Agricultural Changes Due to Water Shortage 91AE0252A Tel Aviv MA ’ARIV in Hebrew 25 Jan 91 p2B Second, I think I am entitled to ask the media the following

JPRS Report, Near East & South Asia

DTIC Science & Technology

1991-05-01

sensitive positions in scientific Elections fields, which has enabled them to examine secrets per- 91AE0336A Amman JORDAN TIMES in English taining to...undertaking major Arab development projects, which establish the pillars of an Arab economic 91AE0338C Tel Aviv MA ’ARIV in Hebrew 8 Mar 91...stability of the Middle East. Toward this goal, it is 91AEO329D TelAviv ’ALHAMISHMAR in Hebrew reasonable that it have an interest in a pact with demo- 8

A novel transition pathway of ligand-induced topological conversion from hybrid forms to parallel forms of human telomeric G-quadruplexes

PubMed Central

Wang, Zi-Fu; Li, Ming-Hao; Chen, Wei-Wen; Hsu, Shang-Te Danny; Chang, Ta-Chau

2016-01-01

The folding topology of DNA G-quadruplexes (G4s) depends not only on their nucleotide sequences but also on environmental factors and/or ligand binding. Here, a G4 ligand, 3,6-bis(1-methyl-4-vinylpyridium iodide)-9-(1-(1-methyl-piperidinium iodide)-3,6,9-trioxaundecane) carbazole (BMVC-8C3O), can induce topological conversion of non-parallel to parallel forms in human telomeric DNA G4s. Nuclear magnetic resonance (NMR) spectroscopy with hydrogen-deuterium exchange (HDX) reveals the presence of persistent imino proton signals corresponding to the central G-quartet during topological conversion of Tel23 and Tel25 G4s from hybrid to parallel forms, implying that the transition pathway mainly involves local rearrangements. In contrast, rapid HDX was observed during the transition of 22-CTA G4 from an anti-parallel form to a parallel form, resulting in complete disappearance of all the imino proton signals, suggesting the involvement of substantial unfolding events associated with the topological transition. Site-specific imino proton NMR assignments of Tel23 G4 enable determination of the interconversion rates of individual guanine bases and detection of the presence of intermediate states. Since the rate of ligand binding is much higher than the rate of ligand-induced topological conversion, a three-state kinetic model was evoked to establish the associated energy diagram for the topological conversion of Tel23 G4 induced by BMVC-8C3O. PMID:26975658

[The beginnings of orthopedic surgery in Israel].

PubMed

Tauber, Chanan

2013-08-01

In early mandatory Israel, orthopedics was mainly conservative, The first modern orthopedic surgeon was Ernst Spira from Czechoslovakia who established an orthopedic service at the Beilinson Hospital in Petah Tikva and left in 1948 to establish the Orthopedic Department and the Rehabilitation Center in Tel Hashomer, which treated the War of Independence casualties including amputees and victims of spinal cord injuries. A second orthopedic department was opened in Tel Hashomer by Shmuel Weissman who left in 1961 to open the Orthopedic Department at the Ichilov hospital in Tel Aviv. Shmuel Weissman became the first Chairman of Orthopedic Surgery at the Tel Aviv University medical school. In 1955, Myer Makin opened a modern orthopedic department in the Hadassah Hospital in Jerusalem and the Alyn Hospital for crippled children. In 1951, Assaf Harofeh Hospital opened the Department of Orthopedic Surgery headed by Anatol Axer who specialized in the treatment and rehabilitation of polio patients. The majority of the second generation of orthopedic department directors was trained by these four surgeons. Major developments in the 1960s and 1970s were the introduction of the AO system revolutionizing fracture treatment from conservative to operative treatment, the advent of total hip and knee replacements, Harrington instrumentation in spinal surgery and arthroscopy were major advances in orthopedic patient care brought to Israel by the aforementioned second generation of orthopedic surgeons. Hand surgery became an independent subspecialty of orthopedics and was lead by the internationally renowned hand surgeon, Isidore Kessler.

Roles of the Checkpoint Sensor Clamp Rad9-Rad1-Hus1 (911)-Complex and the Clamp Loaders Rad17-RFC and Ctf18-RFC in Schizosaccharomyces pombe Telomere Maintenance

PubMed Central

Khair, Lyne; Chang, Ya-Ting; Subramanian, Lakxmi; Russell, Paul; Nakamura, Toru M.

2011-01-01

While telomeres must provide mechanisms to prevent DNA repair and DNA damage checkpoint factors from fusing chromosome ends and causing permanent cell cycle arrest, these factors associate with functional telomeres and play critical roles in the maintenance of telomeres. Previous studies have established that Tel1 (ATM) and Rad3 (ATR) kinases play redundant but essential roles for telomere maintenance in fission yeast. In addition, the Rad9-Rad1-Hus1 (911) and Rad17-RFC complexes work downstream of Rad3 (ATR) in fission yeast telomere maintenance. Here, we investigated how 911, Rad17-RFC and another RFC-like complex Ctf18-RFC contribute to telomere maintenance in fission yeast cells lacking Tel1 and carrying a novel hypomorphic allele of rad3 (DBD-rad3), generated by the fusion between the DNA binding domain (DBD) of the fission yeast telomere capping protein Pot1 and Rad3. Our investigations have uncovered a surprising redundancy for Rad9 and Hus1 in allowing Rad1 to contribute to telomere maintenance in DBD-rad3 tel1Δ cells. In addition, we found that Rad17-RFC and Ctf18-RFC carry out redundant telomere maintenance functions in DBD-rad3 tel1Δ cells. Since checkpoint sensor proteins are highly conserved, genetic redundancies uncovered here may be relevant to telomere maintenance and detection of DNA damage in other eukaryotes. PMID:20505337

A block randomized controlled trial of a brief smoking cessation counselling and advice through short message service on participants who joined the Quit to Win Contest in Hong Kong.

PubMed

Chan, Sophia S C; Wong, David C N; Cheung, Yee Tak Derek; Leung, Doris Y P; Lau, Lisa; Lai, Vienna; Lam, Tai-Hing

2015-08-01

The present trial examined the effectiveness of brief interventions for smokers who joined the Hong Kong Quit to Win Contest to quit smoking. A block randomized controlled trial allocated 1003 adult daily smokers to three groups: (i) The TEL group (n = 338) received a 5-min nurse-led telephone counselling; (ii) The SMS group (n = 335) received eight text messages through mobile phone and (iii) The CONTROL group (n = 330) did not receive the above interventions. Participants with biochemically verified abstinence at 6-month follow-up could receive cash incentive. The primary outcome was the self-reported 7-day point prevalence (PP) of tobacco abstinence at 6-month follow-up. The abstinence rate in the TEL, SMS and CONTROL group was 22.2, 20.6 and 20.3%, respectively (P for TEL versus CONTROL = 0.32; P for SMS versus CONTROL = 0.40). When abstinence at 2-, 6- and 12-month follow-up was modelled simultaneously, the TEL group had a higher abstinence than the CONTROL group (Adjusted OR = 1.38, 95% CI = 1.01-1.88, P = 0 .04). In the Quit to Win Contest, the brief telephone counselling might have increased abstinence, but the text messages had no significant effect. Further studies on intensive intervention and interactive messaging services are warranted. © The Author 2015. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.

Circular dichroism spectroscopic investigation of double-decker phthalocyanine with G-Quadruplex as promising telomerase inhibitor

NASA Astrophysics Data System (ADS)

Baǧda, Efkan; Baǧda, Esra; Yabaş, Ebru

2017-01-01

In the present study, interaction of a double-decker phthalocyanine with two G-quadruplex DNA, Tel 21 and cMYC, was investigated. To the best of our knowledge, this is the first study about G-quadruplex-double decker phthalocyanine interaction. The spectrophotometric titration method was used for binding constant calculations. From the binding constants, it can be said that double-decker phthalocyanine more likely to bind Tel 21 rather than cMYC. The conformational changes upon binding were monitored via circular dichroism spectroscopy. The ethidium bromide replacement assay was investigated spectrofluorometrically.

eLearning or technology enhanced learning in medical education-Hope, not hype.

PubMed

Goh, Poh Sun

2016-09-01

This Personal View elaborates on my strong conviction that the excitement and positive feelings that many of us have for eLearning or Technology enhanced learning (TeL) is well founded, and will argue why our hopes are justified, and not misplaced. In a nutshell, I believe that eLearning or TeL is a significant advance from previous generations of educational innovation, and offers benefits for students, educators and administrators; by synergistically combining the capabilities of digital content, the Internet, and mobile technology, supported by software and applications or "Apps".

Determinants for Tight and Selective Binding of a Medicinal Dicarbene Gold(I) Complex to a Telomeric DNA G-Quadruplex: a Joint ESI MS and XRD Investigation.

PubMed

Bazzicalupi, Carla; Ferraroni, Marta; Papi, Francesco; Massai, Lara; Bertrand, Benoît; Messori, Luigi; Gratteri, Paola; Casini, Angela

2016-03-18

The dicarbene gold(I) complex [Au(9-methylcaffein-8-ylidene)2 ]BF4 is an exceptional organometallic compound of profound interest as a prospective anticancer agent. This gold(I) complex was previously reported to be highly cytotoxic toward various cancer cell lines in vitro and behaves as a selective G-quadruplex stabilizer. Interactions of the gold complex with various telomeric DNA models have been analyzed by a combined ESI MS and X-ray diffraction (XRD) approach. ESI MS measurements confirmed formation of stable adducts between the intact gold(I) complex and Tel 23 DNA sequence. The crystal structure of the adduct formed between [Au(9-methylcaffein-8-ylidene)2 ](+) and Tel 23 DNA G-quadruplex was solved. Tel 23 maintains a characteristic propeller conformation while binding three gold(I) dicarbene moieties at two distinct sites. Stacking interactions appear to drive noncovalent binding of the gold(I) complex. The structural basis for tight gold(I) complex/G-quadruplex recognition and its selectivity are described. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Systematic identification of fragile sites via genome-wide location analysis of γ-H2AX

PubMed Central

Szilard, Rachel K.; Jacques, Pierre-Étienne; Laramée, Louise; Cheng, Benjamin; Galicia, Sarah; Bataille, Alain R.; Yeung, ManTek; Mendez, Megan; Bergeron, Maxime; Robert, François; Durocher, Daniel

2011-01-01

Phosphorylation of histone H2AX is an early response to DNA damage in eukaryotes. In Saccharomyces cerevisiae, DNA damage or replication fork stalling results in histone H2A phosphorylation to yield γ-H2A (yeast γ-H2AX) in a Mec1 (ATR)- and Tel1 (ATM)- dependent manner. Here, we describe the genome-wide location analysis of γ-H2A as a strategy to identify loci prone to engage the Mec1 and Tel1 pathways. Remarkably, γ-H2A enrichment overlaps with loci prone to replication fork stalling and is caused by the action of Mec1 and Tel1, indicating that these loci are prone to breakage. Moreover, about half the sites enriched for γ-H2A map to repressed protein-coding genes, and histone deacetylases are necessary for formation of γ-H2A at these loci. Finally, our work indicates that high resolution mapping of γ-H2AX is a fruitful route to map fragile sites in eukaryotic genomes. PMID:20139982

Perceptions and Impact of Mandatory eLearning for Foundation Trainee Doctors: A Qualitative Evaluation

PubMed Central

Brooks, Hannah L.; Vallance, Hannah K.; Hirsch, Christine A.; Hughes, Elizabeth; Ferner, Robin E.; Marriott, John F.; Coleman, Jamie J.

2016-01-01

Background Junior doctors in the UK must complete various educational components during their two year Foundation training programme. It is important that mandatory learning is informative and engaging. The aim of this study was to evaluate trainee doctors’ perceptions of a Technology Enhanced Learning (TEL) programme developed to improve prescribing competency. Method Focus groups and interviews were conducted at three hospital sites in the West Midlands. Codes, sub-themes and themes were determined using deductive and inductive thematic analysis. Results Data were collected from 38 Foundation trainee doctors. Results revealed major themes relating to prescribing education, the user experience and user engagement. Key findings included the positive impact of preparedness following undergraduate education on the user experience of the TEL programme at the postgraduate level; the impact of content, structure, and individual learning needs and styles on the user experience; and the impact of motivation and time on engagement. Most trainees engaged with the programme owing to its mandatory nature; however, some trainees also used the programme voluntarily, for example, to acquire knowledge prior to starting a new placement. Conclusions It is important to ensure that learners are willing to engage with mandatory TEL, and that they have the time and motivation to do so. It is also important to ensure that learners have a positive user experience and that in designing TEL individual differences in learning styles and needs are taken into account. These findings have implications for educators and system developers in the construction and design of mandatory eLearning programmes. PMID:28005938

Genetic evaluation of childhood acute lymphoblastic leukemia in Iraq using FTA cards.

PubMed

Al-Kzayer, Lika'a Fasih Y; Sakashita, Kazuo; Matsuda, Kazuyuki; Al-Hadad, Salma Abbas; Al-Jadiry, Mazin Faisal; Abed, Wisam Majeed; Abdulkadhim, Jaafar M H; Al-Shujairi, Tariq Abadi; Hasan, Janan Ghalib; Al-Abdullah, Hussam M Salih; Al-Ani, Mouroge H; Saber, Paiman Ali I; Inoshita, Toshi; Kamata, Minoru; Koike, Kenichi

2012-09-01

Genetic examination of childhood leukemia has not been available in Iraq. We here report the frequency of TEL-AML1, E2A-PBX1, MLL-AF4, and BCR-ABL chimeric transcripts in 264 Iraqi children newly diagnosed with acute lymphoblastic leukemia (ALL), using FTA cards impregnated with bone marrow aspirate or whole blood. The diagnosis of ALL was made according to standard French-American-British morphologic criteria. Based on the results of storage temperature and duration, most of the FTA samples were preserved at 4°C for up to 6 weeks in five Iraqi hospitals and then transferred to Japan for molecular analysis. Nested reverse transcription-polymerase chain reaction was adopted for the analysis. TEL-AML1 chimeric transcript product was found in 32 (12.1%) of 264 ALL patients. Eleven (4.2%) patients, 4 (1.5%) patients, and 11 (4.2%) patients had E2A-PBX1 mRNA, MLL-AF4 mRNA, and BCR-ABL mRNA, respectively. One patient had both TEL-AML1 and E2A-PBX1 fusion genes. The incidence of TEL-AML1 in Iraqi ALL children appears to be similar to or slightly higher than those of Jordan (12%) and Kuwait (7%). The prevalence and clinical findings of ALL patients with either E2A-PBX1 or BCR-ABL were comparable to the data reported elsewhere. International collaboration via FTA cards may be helpful to improve diagnosis and management of patients with hematological malignancies in low-income and underdeveloped countries. Copyright © 2012 Wiley Periodicals, Inc.

Perceptions and Impact of Mandatory eLearning for Foundation Trainee Doctors: A Qualitative Evaluation.

PubMed

Brooks, Hannah L; Pontefract, Sarah K; Vallance, Hannah K; Hirsch, Christine A; Hughes, Elizabeth; Ferner, Robin E; Marriott, John F; Coleman, Jamie J

2016-01-01

Junior doctors in the UK must complete various educational components during their two year Foundation training programme. It is important that mandatory learning is informative and engaging. The aim of this study was to evaluate trainee doctors' perceptions of a Technology Enhanced Learning (TEL) programme developed to improve prescribing competency. Focus groups and interviews were conducted at three hospital sites in the West Midlands. Codes, sub-themes and themes were determined using deductive and inductive thematic analysis. Data were collected from 38 Foundation trainee doctors. Results revealed major themes relating to prescribing education, the user experience and user engagement. Key findings included the positive impact of preparedness following undergraduate education on the user experience of the TEL programme at the postgraduate level; the impact of content, structure, and individual learning needs and styles on the user experience; and the impact of motivation and time on engagement. Most trainees engaged with the programme owing to its mandatory nature; however, some trainees also used the programme voluntarily, for example, to acquire knowledge prior to starting a new placement. It is important to ensure that learners are willing to engage with mandatory TEL, and that they have the time and motivation to do so. It is also important to ensure that learners have a positive user experience and that in designing TEL individual differences in learning styles and needs are taken into account. These findings have implications for educators and system developers in the construction and design of mandatory eLearning programmes.

Spatiotemporal trend analysis of metal concentrations in sediments of a residential California stream with toxicity and regulatory implications.

PubMed

Hall, Lenwood W; Anderson, Ronald D; Killen, William D

2017-06-07

The objective of this study was to determine if concentrations of arsenic, cadmium, chromium, copper, lead, nickel and zinc measured in the sediments of a residential stream in California (Pleasant Grove Creek) have changed temporally or spatially from 2006 to 2016. Threshold Effect Levels (TELs), conservative ecological effects benchmarks, and exceedances for the seven metals were also evaluated over the 11-year time period to provide insight into potential metal toxicity to resident benthic communities. In addition, the bioavailability of metals in sediments was also determined by calculating Simultaneous Extracted Metal/Acid Volatle Sulfide (SEM/AVS) ratios to allow an additional assessment of toxicity. Regulatory implications of this data set and the role of metal toxicity are also discussed. Stream-wide temporal trend analysis showed no statistically significant trends for any of the metals. However, spatial analysis for several sites located near storm drains did show a significant increase for most metals over the 11-year period. TEL exceedances during the 7 years of sampling, spanning 2006-2016, were reported for all metals with the number of exceedances ranging from 47 for copper and zinc to 1 for lead. A spatial analysis showed that the highest number of TEL exceedances and the highest number of SEM/AVS ratios greater than one with at least one metal exceeding a TEL occurred at upstream sites. The potentially toxic metal concentrations reported in Pleasant Grove Creek should be used in the 303 (d) listing process for impaired water bodies in California.

"europe Towards the Stars"

NASA Astrophysics Data System (ADS)

1995-06-01

Headquarters in Garching near Munich (Germany) in mid-November 1995. Here they will experience front-line science and partake in the daily life of one of Europe's foremost scientific establishments. Assisted by professional astronomers, they will prepare and carry out real astronomical observations with the 1.4-metre CAT (Coude Auxiliary Telescope) and the very advanced 3.5-metre NTT (New Technology Telescope) from ESO's remote control centre. They will also begin the treatment of the registered data and, if possible, arrive at tentative interpretations. The week will undoubtedly be very hectic, but it will of course also include events of a more social character which will further emphasize the pan-European nature of this unique visit. ESO will provide more details about this programme in early November 1995, including the planned media coverage. ADDRESSES OF THE NATIONAL COMMITTEES For further information about the programme "Europe Towards The Stars", please contact the National Committee in your country. Austria: Prof. H. Mucke, Astronomisches Buero, Hasenwartgasse 32, A-1138 Vienna, Tel. 0043-1-8893541 Belgium: Dr. C. Sterken, Vrije Universiteit Brussel, Campus Ofenplein, Pleinlaan 2, B-1050 Brussels, Tel. 0032-2-6293469, Fax 0032-9-3623976, E-mail csterken@is1.vub.ac.be Denmark: Mr. B. F. Joergensen, Tycho Brahe Planetariet, Gl. Kongevej 10, DK-1610 Copenhagen V, Tel. 0045-33-144888, Fax 0045-33-142888, E-mail tycho@inet.uni-c.dk Finland: Mr. M. Hotakainen, Tahtitieteellinen Yhdistys Ursa Ry, Laivanvarustajankatu 9C 54, FIN-00140 Helsinki, Tel. 00358-0-174048, Fax 00358-0-657728 France: Mr. B. Pellequer, Geospace d'Aniane, Boîte Postale 22, F-34150 Aniane, Tel. 0033-6-7034949, Fax 0033-6-7752864 Germany: Dr. K.-H. Lotze, Friedrich-Schiller-Universitaet, Max-Wien-Platz 1, D-07743 Jena, Germany, Tel. +49-3641-635904/636654, Fax +49-3641-636728 Greece: Dr. D. Simopoulos, Eugenides Foundation, Astronomy Department, 387 Sygrou Avenue, Palaio Faliro, GR-175 64 Athens, Tel

TLR4/MyD88/NF-κB signaling and PPAR-γ within the paraventricular nucleus are involved in the effects of telmisartan in hypertension

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, Hong-Bao; Li, Xiang; Huo, Chan-Juan

Previous findings from our laboratory and others indicate that the main therapeutic effect of angiotensin II type 1 receptor (AT1-R) antagonists is to decrease blood pressure and exert anti-inflammatory effects in the cardiovascular system. In this study, we determined whether AT1-R antagonist telmisartan within the hypothalamic paraventricular nucleus (PVN) attenuates hypertension and hypothalamic inflammation via both the TLR4/MyD88/NF-κB signaling pathway and peroxisome proliferator-activated receptor-γ (PPAR-γ) in the PVN in hypertensive rats. Spontaneously hypertensive rats (SHR) and normotensive Wistar Kyoto (WKY) rats were treated for 4 weeks through bilateral PVN infusion with the AT1-R antagonist telmisartan (TEL, 10 μg/h), or losartanmore » (LOS, 20 μg/h), or the PPAR-γ antagonist GW9662 (GW, 100 μg/h), or vehicle via osmotic minipump. Mean arterial pressure (MAP) was recorded by a tail-cuff occlusion method. PVN tissue and blood were collected for the measurement of AT1-R, PPAR-γ, pro-inflammatory cytokines (tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6), inducible nitric oxide synthase (iNOS), TLR4, MyD88, nuclear factor-kappa B (NF-κB) activity and plasma norepinephrine (NE), respectively. Hypertensive rats exhibited significantly higher level of AT1-R and lower level of PPAR-γ in the PVN. PVN treatment with TEL attenuated MAP, improved cardiac hypertrophy, reduced TNF-α, IL-1β, IL-6, iNOS levels, and plasma NE in SHR but not in WKY rats. These results were associated with reduced TLR4, MyD88 and NF-κB levels and increased PPAR-γ level in the PVN of hypertensive rats. Our findings suggest that TLR4/MyD88/NF-κB signaling and PPAR-γ within the PVN are involved in the beneficial effects of telmisartan in hypertension. - Highlights: • PVN infusion of TEL in spontaneously hypertensive rats is reported. • PVN infusion of TEL attenuates hypertension and proinflammatory cytokines in PVN. • PVN blockade of AT1-R attenuates

Construction and Characterization of an in-vivo Linear Covalently Closed DNA Vector Production System

PubMed Central

2012-01-01

Background While safer than their viral counterparts, conventional non-viral gene delivery DNA vectors offer a limited safety profile. They often result in the delivery of unwanted prokaryotic sequences, antibiotic resistance genes, and the bacterial origins of replication to the target, which may lead to the stimulation of unwanted immunological responses due to their chimeric DNA composition. Such vectors may also impart the potential for chromosomal integration, thus potentiating oncogenesis. We sought to engineer an in vivo system for the quick and simple production of safer DNA vector alternatives that were devoid of non-transgene bacterial sequences and would lethally disrupt the host chromosome in the event of an unwanted vector integration event. Results We constructed a parent eukaryotic expression vector possessing a specialized manufactured multi-target site called “Super Sequence”, and engineered E. coli cells (R-cell) that conditionally produce phage-derived recombinase Tel (PY54), TelN (N15), or Cre (P1). Passage of the parent plasmid vector through R-cells under optimized conditions, resulted in rapid, efficient, and one step in vivo generation of mini lcc—linear covalently closed (Tel/TelN-cell), or mini ccc—circular covalently closed (Cre-cell), DNA constructs, separated from the backbone plasmid DNA. Site-specific integration of lcc plasmids into the host chromosome resulted in chromosomal disruption and 105 fold lower viability than that seen with the ccc counterpart. Conclusion We offer a high efficiency mini DNA vector production system that confers simple, rapid and scalable in vivo production of mini lcc DNA vectors that possess all the benefits of “minicircle” DNA vectors and virtually eliminate the potential for undesirable vector integration events. PMID:23216697

Construction and characterization of an in-vivo linear covalently closed DNA vector production system.

PubMed

Nafissi, Nafiseh; Slavcev, Roderick

2012-12-06

While safer than their viral counterparts, conventional non-viral gene delivery DNA vectors offer a limited safety profile. They often result in the delivery of unwanted prokaryotic sequences, antibiotic resistance genes, and the bacterial origins of replication to the target, which may lead to the stimulation of unwanted immunological responses due to their chimeric DNA composition. Such vectors may also impart the potential for chromosomal integration, thus potentiating oncogenesis. We sought to engineer an in vivo system for the quick and simple production of safer DNA vector alternatives that were devoid of non-transgene bacterial sequences and would lethally disrupt the host chromosome in the event of an unwanted vector integration event. We constructed a parent eukaryotic expression vector possessing a specialized manufactured multi-target site called "Super Sequence", and engineered E. coli cells (R-cell) that conditionally produce phage-derived recombinase Tel (PY54), TelN (N15), or Cre (P1). Passage of the parent plasmid vector through R-cells under optimized conditions, resulted in rapid, efficient, and one step in vivo generation of mini lcc--linear covalently closed (Tel/TelN-cell), or mini ccc--circular covalently closed (Cre-cell), DNA constructs, separated from the backbone plasmid DNA. Site-specific integration of lcc plasmids into the host chromosome resulted in chromosomal disruption and 10(5) fold lower viability than that seen with the ccc counterpart. We offer a high efficiency mini DNA vector production system that confers simple, rapid and scalable in vivo production of mini lcc DNA vectors that possess all the benefits of "minicircle" DNA vectors and virtually eliminate the potential for undesirable vector integration events.

The Handover Toolbox: a knowledge exchange and training platform for improving patient care.

PubMed

Drachsler, Hendrik; Kicken, Wendy; van der Klink, Marcel; Stoyanov, Slavi; Boshuizen, Henny P A; Barach, Paul

2012-12-01

Safe and effective patient handovers remain a global organisational and training challenge. Limited evidence supports available handover training programmes. Customisable training is a promising approach to improve the quality and sustainability of handover training and outcomes. We present a Handover Toolbox designed in the context of the European HANDOVER Project. The Toolbox aims to support physicians, nurses, individuals in health professions training, medical educators and handover experts by providing customised handover training tools for different clinical needs and contexts. The Handover Toolbox uses the Technology Enhanced Learning Design Process (TEL-DP), which encompasses user requirements analysis; writing personas; group concept mapping; analysis of suitable software; plus, minus, interesting rating; and usability testing. TEL-DP is aligned with participatory design approaches and ensures development occurs in close collaboration with, and engagement of, key stakeholders. Application of TEL-DP confirmed that the ideal formats of handover training differs for practicing professionals versus individuals in health profession education programmes. Training experts from different countries differed in their views on the optimal content and delivery of training. Analysis of suitable software identified ready-to-use systems that provide required functionalities and can be further customised to users' needs. Interest rating and usability testing resulted in improved usability, navigation and uptake of the Handover Toolbox. The design of the Handover Toolbox was based on a carefully led stakeholder participatory design using the TEL-DP approach. The Toolbox supports a customisable learning approach that allows trainers to design training that addresses the specific information needs of the various target groups. We offer recommendations regarding the application of the Handover Toolbox to medical educators.

Rearrangement of Upstream Sequences of the hTERT Gene During Cellular Immortalization

PubMed Central

Zhao, Yuanjun; Wang, Shuwen; Popova, Evgenya Y.; Grigoryev, Sergei A.; Zhu, Jiyue

2010-01-01

Telomerase expression, resulting from transcriptional activation of the hTERT gene, allows cells to acquire indefinite proliferative potential during cellular immortalization and tumorigenesis. However, mechanisms of hTERT gene activation in many immortal cell lines and cancer cells are poorly understood. Here, we report our studies on hTERT activation using genetically related pairs of telomerase-negative (Tel−) and -positive (Tel+) fibroblast lines. First, whereas transiently transfected plasmid reporters did not recapitulate the endogenous hTERT promoter, the promoter in chromosomally integrated bacterial artificial chromosome (BAC) reporters was activated in a subset of Tel+ cells, indicating that activation of the hTERT promoter required native chromatin context and/or distal regulatory elements. Second, the hTERT gene, located near the telomere of chromosome 5p, was translocated in all three Tel+ cell lines but not in their parental pre-crisis cells and Tel− immortal siblings. The breakage points were mapped to regions upstream of the hTERT promoter, indicating that the hTERT gene was the target of these chromosomal rearrangements. In two Tel+ cell lines, translocation of the endogenous hTERT gene appeared to be the major mechanism of its activation as the activity of hTERT promoter in many chromosomally integrated BAC reporters, with intact upstream and downstream neighboring loci, remained relatively low. Therefore, our results suggest that rearrangement of upstream sequences is an important new mechanism of hTERT promoter activation during cellular immortalization. The chromosomal rearrangements likely occurred during cellular crisis and facilitated by telomere dysfunction. Such translocations allowed the hTERT promoter to escape from the native condensed chromatin environment. PMID:19672873

Same-sex sexual attraction, behavior, and practices of Jewish men in Israel and the association with HIV prevalence.

PubMed

Mor, Zohar; Davidovich, Udi

2016-01-01

In order to efficiently direct efforts and resources required for the prevention of HIV and other sexually transmitted infection among men who have sex with men (MSM) in Israel, it is necessary to define their particular behaviors, estimate their size, and asses the HIV-burden. This cross-sectional study included a sub-sample from a random representative National study performed in Israel, which included Jewish males aged 18-44 who completed online anonymous questionnaires regarding their sexual attraction and practices, commercial sex-work, as well as condom and substances' use. Additionally, participants were asked to identify themselves as gay, bisexual, or heterosexual. National estimates regarding prevalence of risk-behaviors and HIV-infection among MSM were based on the Statistical Abstract of Israel and the National HIV Registry, respectively. Of the total sample of 997 men, 11.9% reported lifetime male sex encounters, while 4.5% and 3.7% self-identified as gay or bisexual, respectively. The estimated population of self-identified Jewish gays/bisexuals aged 18-44 in Israel was 94,176, and in Tel-Aviv 33,839. HIV prevalence among MSM was estimated at 0.7% in Israel and 1.0% in Tel-Aviv. MSM were more likely to live in Tel-Aviv, had higher levels of education, and were scored higher on several determinants of sexual risk in comparison to those attracted to women, including early sexual debut, greater number of sexual partners, ever paid/been paid for sex, sexually coerced, and substance use. In conclusion, MSM were involved in greater risk behaviors than those who only had female sex partners. Most MSM were living in Tel-Aviv and their estimated HIV prevalence was 1.0%.

G-quadruplex formation in telomeres enhances POT1/TPP1 protection against RPA binding

PubMed Central

Ray, Sujay; Bandaria, Jigar N.; Qureshi, Mohammad H.; Yildiz, Ahmet; Balci, Hamza

2014-01-01

Human telomeres terminate with a single-stranded 3′ G overhang, which can be recognized as a DNA damage site by replication protein A (RPA). The protection of telomeres (POT1)/POT1-interacting protein 1 (TPP1) heterodimer binds specifically to single-stranded telomeric DNA (ssTEL) and protects G overhangs against RPA binding. The G overhang spontaneously folds into various G-quadruplex (GQ) conformations. It remains unclear whether GQ formation affects the ability of POT1/TPP1 to compete against RPA to access ssTEL. Using single-molecule Förster resonance energy transfer, we showed that POT1 stably loads to a minimal DNA sequence adjacent to a folded GQ. At 150 mM K+, POT1 loading unfolds the antiparallel GQ, as the parallel conformation remains folded. POT1/TPP1 loading blocks RPA’s access to both folded and unfolded telomeres by two orders of magnitude. This protection is not observed at 150 mM Na+, in which ssTEL forms only a less-stable antiparallel GQ. These results suggest that GQ formation of telomeric overhangs may contribute to suppression of DNA damage signals. PMID:24516170

Survey on Intelligent Assistance for Workplace Learning in Software Engineering

NASA Astrophysics Data System (ADS)

Ras, Eric; Rech, Jörg

Technology-enhanced learning (TEL) systems and intelligent assistance systems aim at supporting software engineers during learning and work. A questionnaire-based survey with 89 responses from industry was conducted to find out what kinds of services should be provided and how, as well as to determine which software engineering phases they should focus on. In this paper, we present the survey results regarding intelligent assistance for workplace learning in software engineering. We analyzed whether specific types of assistance depend on the organization's size, the respondent's role, and the experience level. The results show a demand for TEL that supports short-term problem solving and long-term competence development at the workplace.

[Online text-based psychosocial intervention for Youth in Quebec].

PubMed

Thoër, Christine; Noiseux, Kathia; Siche, Fabienne; Palardy, Caroline; Vanier, Claire; Vrignaud, Caroline

In 2013, Tel-jeunes created a text messaging intervention program to reach youth aged 12 to 17 years on their cell phones. Tel-jeunes was the first in the country to offer a text-based brief psychosocial interventions performed by professional counselors. Researchers were contacted to document and evaluate the program. The research aimed to: 1) determine motives, contexts and issues that lead young people to use the SMS service; 2) document the characteristics of text-based brief intervention; and 3) assess the advantages and difficulties encountered by counselors who respounded to youth text-messages. We conducted a multimethod research from November 2013 to May 2014. We held four focus groups with 23 adolescents aged 15 to 17 who had or not used the SMS service, conducted a content analysis of a corpus of 13,236 text messages (or 601 conversations), and two focus groups with 11 Tel-jeunes counselors, just over a year after the implantation of the service. Our findings show that the SMS service meets youth needs. They identify text messaging to be their prefered mode of communication with Tel-jeunes when they need support or information. Moreover, the service reaches young people who would not have felt confortable to contact Tel-jeunes by phone. We identified three dominant issues in youths demands: romantic relationships, psychological health and sexuality. Perceived benefits of the service include anonimity and privacy (cell phone providing the ability to text anywhere). Youth participants also appreciated writing to counselors as they felt they had more time to think abouth their questions and answers to the counselor. Counselors were more ambivalent. They considered text-based intervention to be very effective and satisfactory to adress youth information requests, but reported difficulties when dealing with more complex problems or with mental health issues. They reported that text-based communication makes it more difficult to assess youth emotional states

[Multimedia (visual collaboration) brings true nature of human life].

PubMed

Tomita, N

2000-03-01

Videoconferencing system, high-quality visual collaboration, is bringing Multimedia into a society. Multimedia, high quality media such as TV broadcast, looks expensive because it requires broadband network with 100-200 Mpbs bandwidth or 3,700 analog telephone lines. However, thanks to the existing digital-line called N-ISDN (Narrow Integrated Service Digital Network) and PictureTel's audio/video compression technologies, it becomes far less expensive. N-ISDN provides 128 Kbps bandwidth, over twice wider than analog line. PictureTel's technology instantly compress audio/video signal into 1/1,000 in size. This means, with ISDN and PictureTel technology. Multimedia is materialized over even single ISDN line. This will allow doctor to remotely meet face-to-face with a medical specialist or patients to interview, conduct physical examinations, review records, and prescribe treatments. Bonding multiple ISDN lines will further improve video quality that enables remote surgery. Surgeon can perform an operation on internal organ by projecting motion video from Endoscope's CCD camera to large display monitor. Also, PictureTel provides advanced technologies of eliminating background noise generated by surgical knives or scalpels during surgery. This will allow sound of the breath or heartbeat be clearly transmitted to the remote site. Thus, Multimedia eliminates the barrier of distance, enabling people to be just at home, to be anywhere in the world, to undergo up-to-date medical treatment by expertise. This will reduce medical cost and allow people to live in the suburbs, in less pollution, closer to the nature. People will foster more open and collaborative environment by participating in local activities. Such community-oriented life-style will atone for mass consumption, materialistic economy in the past, then bring true happiness and welfare into our life after all.

Two Siblings with Alternate Unbalanced Recombinants Derived from a Large Cryptic Maternal Pericentric Inversion of Chromosome 20

PubMed Central

DeScipio, Cheryl; Morrissette, Jennifer J.D.; Conlin, Laura K.; Clark, Dinah; Kaur, Maninder; Coplan, James; Riethman, Harold; Spinner, Nancy B.; Krantz, Ian D.

2009-01-01

Two brothers, with dissimilar clinical features, were each found to have different abnormalities of chromosome 20 by subtelomere fluorescence in situ hybridization (FISH). The proband had deletion of 20p subtelomere and duplication of 20q subtelomere, while his brother was found to have a duplication of 20p subtelomere and deletion of 20q subtelomere. Parental cytogenetic studies were initially thought to be normal, both by G-banding and by subtelomere FISH analysis. Since chromosome 20 is a metacentric chromosome and an inversion was suspected, we used anchored FISH to assist in identifying a possible inversion. This approach employed concomitant hybridization of a FISH probe to the short (p) arm of chromosome 20 with the 20q subtelomere probe. We identified a cytogenetically non-visible, mosaic pericentric inversion of one of the maternal chromosome 20 homologues, providing a mechanistic explanation for the chromosomal abnormalities present in these brothers. Array comparative genomic hybridization (CGH) with both a custom-made BAC and cosmid-based subtelomere specific array (TEL array) and a commercially-available SNP-based array confirmed and further characterized these rearrangements, identifying this as the largest pericentric inversion of chromosome 20 described to date. TEL array data indicate that the 20p breakpoint is defined by BAC RP11-978M13, ~900 kb from the pter; SNP array data reveal this breakpoint to occur within BAC RP11-978M13. The 20q breakpoint is defined by BAC RP11-93B14, ~1.7 Mb from the qter, by TEL array; SNP array data refine this breakpoint to within a gap between BACs on the TEL array (i.e. between RP11-93B14 and proximal BAC RP11-765G16). PMID:20101690

Two siblings with alternate unbalanced recombinants derived from a large cryptic maternal pericentric inversion of chromosome 20.

PubMed

Descipio, Cheryl; Morrissette, Jennifer D; Conlin, Laura K; Clark, Dinah; Kaur, Maninder; Coplan, James; Riethman, Harold; Spinner, Nancy B; Krantz, Ian D

2010-02-01

Two brothers, with dissimilar clinical features, were each found to have different abnormalities of chromosome 20 by subtelomere fluorescence in situ hybridization (FISH). The proband had deletion of 20p subtelomere and duplication of 20q subtelomere, while his brother was found to have a duplication of 20p subtelomere and deletion of 20q subtelomere. Parental cytogenetic studies were initially thought to be normal, both by G-banding and by subtelomere FISH analysis. Since chromosome 20 is a metacentric chromosome and an inversion was suspected, we used anchored FISH to assist in identifying a possible inversion. This approach employed concomitant hybridization of a FISH probe to the short (p) arm of chromosome 20 with the 20q subtelomere probe. We identified a cytogenetically non-visible, mosaic pericentric inversion of one of the maternal chromosome 20 homologs, providing a mechanistic explanation for the chromosomal abnormalities present in these brothers. Array comparative genomic hybridization (CGH) with both a custom-made BAC and cosmid-based subtelomere specific array (TEL array) and a commercially available SNP-based array confirmed and further characterized these rearrangements, identifying this as the largest pericentric inversion of chromosome 20 described to date. TEL array data indicate that the 20p breakpoint is defined by BAC RP11-978M13, approximately 900 kb from the pter; SNP array data reveal this breakpoint to occur within BAC RP11-978M13. The 20q breakpoint is defined by BAC RP11-93B14, approximately 1.7 Mb from the qter, by TEL array; SNP array data refine this breakpoint to within a gap between BACs on the TEL array (i.e., between RP11-93B14 and proximal BAC RP11-765G16). Copyright 2010 Wiley-Liss, Inc.

Same-sex sexual attraction, behavior, and practices of Jewish men in Israel and the association with HIV prevalence

PubMed Central

Mor, Zohar; Davidovich, Udi

2016-01-01

ABSTRACT In order to efficiently direct efforts and resources required for the prevention of HIV and other sexually transmitted infection among men who have sex with men (MSM) in Israel, it is necessary to define their particular behaviors, estimate their size, and asses the HIV-burden. This cross-sectional study included a sub-sample from a random representative National study performed in Israel, which included Jewish males aged 18–44 who completed online anonymous questionnaires regarding their sexual attraction and practices, commercial sex-work, as well as condom and substances' use. Additionally, participants were asked to identify themselves as gay, bisexual, or heterosexual. National estimates regarding prevalence of risk-behaviors and HIV-infection among MSM were based on the Statistical Abstract of Israel and the National HIV Registry, respectively. Of the total sample of 997 men, 11.9% reported lifetime male sex encounters, while 4.5% and 3.7% self-identified as gay or bisexual, respectively. The estimated population of self-identified Jewish gays/bisexuals aged 18–44 in Israel was 94,176, and in Tel-Aviv 33,839. HIV prevalence among MSM was estimated at 0.7% in Israel and 1.0% in Tel-Aviv. MSM were more likely to live in Tel-Aviv, had higher levels of education, and were scored higher on several determinants of sexual risk in comparison to those attracted to women, including early sexual debut, greater number of sexual partners, ever paid/been paid for sex, sexually coerced, and substance use. In conclusion, MSM were involved in greater risk behaviors than those who only had female sex partners. Most MSM were living in Tel-Aviv and their estimated HIV prevalence was 1.0%. PMID:26883581

A 6 kV arbitrary waveform generator for the Tevatron Electron Lens

DOE PAGES

Pfeffer, H.; Saewert, G.

2011-11-09

This paper reports on a 6 kV modulator built and installed at Fermilab to drive the electron gun anode for the Tevatron Electron Lens (TEL). The TEL was built with the intention of shifting the individual (anti)proton bunch tunes to even out the tune spread among all 36 bunches with the desire of improving Tevatron integrated luminosity. This modulator is essentially a 6 kV arbitrary waveform generator that enables the TEL to define the electron beam intensity on a bunch-by-bunch basis. A voltage waveform is constructed having a 7 μs duration that corresponds to the tune shift requirements of amore » 12-bunch (anti)proton beam pulse train. This waveform is played out for any one or all three bunch trains in the Tevatron. The programmed waveform voltages transition to different levels at time intervals corresponding to the 395 ns bunch spacing. In addition, complex voltage waveforms can be played out at a sustained rate of 143 kHz over the full 6 kV output range. This paper describes the novel design of the inductive adder topology employing five transformers. It describes the design aspects that minimize switching losses for this multi-kilovolt, high repetition rate and high duty factor application.« less

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pfeffer, H.; Saewert, G.

This paper reports on a 6 kV modulator built and installed at Fermilab to drive the electron gun anode for the Tevatron Electron Lens (TEL). The TEL was built with the intention of shifting the individual (anti)proton bunch tunes to even out the tune spread among all 36 bunches with the desire of improving Tevatron integrated luminosity. This modulator is essentially a 6 kV arbitrary waveform generator that enables the TEL to define the electron beam intensity on a bunch-by-bunch basis. A voltage waveform is constructed having a 7 μs duration that corresponds to the tune shift requirements of amore » 12-bunch (anti)proton beam pulse train. This waveform is played out for any one or all three bunch trains in the Tevatron. The programmed waveform voltages transition to different levels at time intervals corresponding to the 395 ns bunch spacing. In addition, complex voltage waveforms can be played out at a sustained rate of 143 kHz over the full 6 kV output range. This paper describes the novel design of the inductive adder topology employing five transformers. It describes the design aspects that minimize switching losses for this multi-kilovolt, high repetition rate and high duty factor application.« less

Tinea capitis outbreak among paediatric refugee population, an evolving healthcare challenge.

PubMed

Mashiah, Jacob; Kutz, Ana; Ben Ami, Ronen; Savion, Mihal; Goldberg, Ilan; Gan Or, Tamar; Zidan, Omri; Sprecher, Eli; Harel, Avikam

2016-09-01

Outbreaks of tinea capitis (TC) represent a major medical and economic burden. Population migrations have become a phenomenon of increasing relevance for medical conditions management. Given the recent massive arrival of immigrants, we sought to determine epidemiologic trends for TC among paediatric populations at the Tel Aviv Medical Center. We conducted a retrospective study of all TC cases diagnosed between 2010 and 2014 in a paediatric dermatology unit of a tertiary medical centre, serving as a referral centre for the paediatric refugee population from the great Tel Aviv area. Epidemiologic, clinical and treatment data including effectiveness and safety were reviewed. In all, 145 children met the inclusion criteria. Trend analyses showed increases in TC rates over the study period. Incidence rates were higher in boys than in girls. Children of African origin had the highest TC incidence rates as compared with other ethnic groups. Trichophyton violaceum and Microsporum audouinii were the predominant causative organisms. Treatment with griseofulvin was satisfactory in all cases. There was a significant increase in TC incidence rates in the Tel Aviv area over the study period. TV and MA were the predominant organisms. These trends may be a result of poor living conditions and crowded school premises. © 2016 Blackwell Verlag GmbH.

Rapid Cdc13 turnover and telomere length homeostasis are controlled by Cdk1-mediated phosphorylation of Cdc13.

PubMed

Tseng, Shun-Fu; Shen, Zih-Jie; Tsai, Hung-Ji; Lin, Yi-Hsuan; Teng, Shu-Chun

2009-06-01

Budding yeast telomerase is mainly activated by Tel1/Mec1 (yeast ATM/ATR) on Cdc13 from late S to G2 phase of the cell cycle. Here, we demonstrated that the telomerase-recruitment domain of Cdc13 is also phosphorylated by Cdk1 at the same cell cycle stage as the Tel1/Mec1-dependent regulation. Phosphor-specific gel analysis demonstrated that Cdk1 phosphorylates residues 308 and 336 of Cdc13. The residue T308 of Cdc13 is critical for efficient Mec1-mediated S306 phosphorylation in vitro. Phenotypic analysis in vivo revealed that the mutations in the Cdc13 S/TP motifs phosphorylated by Cdk1 caused cell cycle delay and telomere shortening and these phenotypes could be partially restored by the replacement with a negative charge residue. In the absence of Ku or Tel1, Cdk1-mediated phosphorylation of Cdc13 showed no effect on telomere length maintenance. Moreover, this Cdk1-mediated phosphorylation was required to promote the regular turnover of Cdc13. Together these results demonstrate that Cdk1 phosphorylates the telomerase recruitment domain of Cdc13, thereby preserves optimal function and expression level of Cdc13 for precise telomere replication and cell cycle progression.

Symmetry based assembly of a 2 dimensional protein lattice

DOE Office of Scientific and Technical Information (OSTI.GOV)

Poulos, Sandra; Agah, Sayeh; Jallah, Nikardi

2017-04-18

The design of proteins that self-assemble into higher order architectures is of great interest due to their potential application in nanotechnology. Specifically, the self-assembly of proteins into ordered lattices is of special interest to the field of structural biology. Here we designed a 2 dimensional (2D) protein lattice using a fusion of a tandem repeat of three TelSAM domains (TTT) to the Ferric uptake regulator (FUR) domain. We determined the structure of the designed (TTT-FUR) fusion protein to 2.3 Å by X-ray crystallographic methods. In agreement with the design, a 2D lattice composed of TelSAM fibers interdigitated by the FURmore » domain was observed. As expected, the fusion of a tandem repeat of three TelSAM domains formed 21 screw axis, and the self-assembly of the ordered oligomer was under pH control. We demonstrated that the fusion of TTT to a domain having a 2-fold symmetry, such as the FUR domain, can produce an ordered 2D lattice. The TTT-FUR system combines features from the rotational symmetry matching approach with the oligomer driven crystallization method. This TTT-FUR fusion was amenable to X-ray crystallographic methods, and is a promising crystallization chaperone.« less

Quark Matter 2011 (QM11) Quark Matter 2011 (QM11)

NASA Astrophysics Data System (ADS)

2011-12-01

International Advisory Committee Antinori, FedericoPaic, Guy Braun-Munzinger, PeterPajares, Carlos Cifarelli, LuisaPeitzmann, Thomas Erazmus, BarbaraRedlich, Krzysztof Eskola, KariRiccati, Lodovico Gaardhøje, Jens JørgenRoland, Gunther Gale, CharlesRoy, Christelle Gelis, FrancoisSchukraft, Jürgen Giubellino, PaoloSinha, Bikash Greiner, CarstenSrivastava, Dinesh Gyulassy, MiklosStachel, Johanna Harris, JohnSteinberg, Peter Hatsuda, TetsuoStroth, Joachim Heinz, UlrichSugitate, Toru Jacak, BarbaraTserruya, Itzhak Karsch, FrithjofVelkovska, Julia Kharzeev, DimaWang, Enke Kodama, TakeshiWang, Xin, Nian Lévai, PéterWessels, Johannes Manko, VladislavXu, Nu Müller, BerndtZajc, William Ollitrault, Jean-Yves Organizing Committee Arleo, FrancoisDupieux, Pascal Bastid, NicoleFurget, Christophe Bourgeois, Marie-LaureGranier de Cassagnac, Raphael Bregant, MarcoGuernane, Rachid Carminati, FedericoHervet, Carnita Castillo, JavierKuhn, Christian Cheynis, BrigitteOlivier, Nathalie Conesa, DelValle, Zaida Connor, MichelleRenshall, Lucy Crochet, PhilippeSuire, Christophe Delagrange, HuguesTihinen, Ulla Program Committee Schutz, Yves (Chair)Baldisseri, Alberto Wiedemann, Urs (co-Chair)Safarik, Karel Aurenche, Patrick

Turbine Engine Loads Simulator (TELS) Radiographic Systems Requirements Study

DTIC Science & Technology

1977-06-01

cell and viewed from the rear. Locations of the rotor case pinch points are illustrated in Figures C-4 through C-! 9. Table C-Ill represents the test...radiation is also attentuated by air, therefore we can write: pb2 03 EXP(~a b) ( El4 ) W = [ K---~-T X1 ] Let U = T = 1, P = 0.01 rads, #a = 3 x 10 -5 cm

Mobile Text Messaging to Improve Medication Adherence and Viral Load in a Vulnerable Canadian Population Living With Human Immunodeficiency Virus: A Repeated Measures Study

PubMed Central

King, Elizabeth; Kinvig, Karen; Steif, Jonathan; Qiu, Annie Q; Maan, Evelyn J; Albert, Arianne YK; Pick, Neora; Alimenti, Ariane; Kestler, Mary H; Money, Deborah M; Lester, Richard T

2017-01-01

Background Combination antiretroviral therapy (cART) as treatment for human immunodeficiency virus (HIV) infection is effective and available, but poor medication adherence limits benefits, particularly in vulnerable populations. In a Kenyan randomized controlled trial, a weekly text-messaging intervention (WelTel) improved cART adherence and HIV viral load (VL). Despite growing evidence for short message service (SMS) text-message interventions in HIV care, there is a paucity of data utilizing these interventions in marginalized or female cohorts. Objective This study was undertaken to assess whether the standardized WelTel SMS text-message intervention applied to a vulnerable, predominantly female, population improved cART adherence and VL. Methods We conducted a repeated measures study of the WelTel intervention in high-risk HIV-positive persons by measuring change in VL, CD4 count, and self-reported adherence 12 months before and 12 months after the WelTel intervention was introduced. Inclusion criteria included VL ≥200 copies/mL, indication for treatment, and meeting vulnerability criteria. Participants were given a mobile phone with unlimited texting (where required), and weekly check-in text messages were sent for one year from the WelTel computer platform. Clinical data were collected for control and intervention years. Participants were followed by a multidisciplinary team in a clinical setting. Outcomes were assessed using Wilcoxon signed ranks tests for change in CD4 and VL from control year to study end and mixed-effects logistic regressions for change in cART adherence and appointment attendance. A secondary analysis was conducted to assess the effect of response rate on the outcome by modeling final log10 VL by number of responses while controlling for mean log10 VL in the control year. Results Eighty-five participants enrolled in the study, but 5 withdrew (final N=80). Participants were predominantly female (90%, 72/80) with a variety of

Tracheal reaction to three different intraluminal stents in an animal model of tracheomalacia.

PubMed

Weinberg, Mark; Sandbank, Judith; Flumenblit, Yoseph; Klin, Baruch; Vinograd, Itzhak

2005-06-01

Three different internal airway stents were studied in an animal model of tracheomalacia: the Palmaz stent (Johnson & Johnson, Warren, New Jersey) and the NIR stent (Medinol Ltd., Tel Aviv, Israel)--both made of stainless steel in the form of tubular mesh--and the Nitinol stent, made of nickel-titanium formed into a spiral shape. All three stents could be adequately stabilized in the malacic tracheal segment. The Nitinol stent (Medinol Ltd., Tel Aviv, Israel) proved to be less reactive to the tracheal mucosa, demonstrated higher biocompatibility with significantly less granulation tissue formation, and showed superior radial resistance. Extraction of the Nitinol stent also proved to be much smoother. This stent may be the stent of choice in the treatment of tracheo- and bronchomalacia.

Circumstellar Dust in Symbiotic Novae

NASA Astrophysics Data System (ADS)

Jurkic, T.; Kotnik-Karuza, D.

2015-12-01

We present a model of inner dust regions around the cool Mira component of the two symbiotic novae, RR Tel and HM Sge, based on the near-IR photometry, ISO spectra and mid-IR interferometry. The dust properties were determined using the DUSTY code. A compact circumstellar silicate dust shell with inner dust shell temperatures between 900 K and 1300 K and of moderate optical depth can explain all the observations. RR Tel shows the presence of an equatorially enhanced dust density during minimum obscuration. Obscuration events are explained by an increase in optical depth caused by the newly condensed dust. The mass loss rates are significantly higher than in intermediate-period single Miras but in agreement with longer-period O-rich AGB stars.

75 FR 5322 - Formations of, Acquisitions by, and Mergers of Bank Holding Companies

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-02

....5 percent of the outstanding voting shares of Israel Discount Bank, Ltd., Tel Aviv, Israel, and thereby indirectly acquire additional voting shares of Discount Bancorp Inc., and Israel Discount Bank of...

Effect of an interactive text-messaging service on patient retention during the first year of HIV care in Kenya (WelTel Retain): an open-label, randomised parallel-group study.

PubMed

van der Kop, Mia Liisa; Muhula, Samuel; Nagide, Patrick I; Thabane, Lehana; Gelmon, Lawrence; Awiti, Patricia Opondo; Abunah, Bonface; Kyomuhangi, Lennie Bazira; Budd, Matthew A; Marra, Carlo; Patel, Anik; Karanja, Sarah; Ojakaa, David I; Mills, Edward J; Ekström, Anna Mia; Lester, Richard Todd

2018-03-01

Retention of patients in HIV care is crucial to ensure timely treatment initiation, viral suppression, and to avert AIDS-related deaths. We did a randomised trial to determine whether a text-messaging intervention improved retention during the first year of HIV care. This unmasked, randomised parallel-group study was done at two clinics in informal settlements in Nairobi, Kenya. Eligible participants were aged 18 years or older, HIV-positive, had their own mobile phone or access to one, and were able to use simple text messaging (or have somebody who could text message on their behalf). Participants were randomly assigned (1:1), with random block sizes of 2, 4, and 6, to the intervention or control group. Participants in the intervention group received a weekly text message from the automated WelTel service for 1 year and were asked to respond within 48 h. Participants in the control group did not receive text messages. Participants in both groups received usual care, which comprised psychosocial support and counselling; patient education; CD4 cell count; treatment; screening for tuberculosis, opportunistic infections, and sexually transmitted infections; prevention of mother-to-child transmission and family planning services; and up to two telephone calls for missed appointments. The primary outcome was retention in care at 12 months (ie, clinic attendance 10-14 months after the first visit). Participants who did not attend this 12-month appointment were traced, and we considered as retained those who were confirmed to be active in care elsewhere. The data analyst and clinic staff were masked to the group assignment, whereas participants and research nurses were not. We analysed the intention-to-treat population. This trial is registered with ClinicalTrials.gov, number NCT01630304. Between April 4, 2013, and June 4, 2015, we screened 1068 individuals, of whom 700 were recruited. 349 people were allocated to the intervention group and 351 to the control group

Tritium in well waters, streams and atomic lakes in the East Kazakhstan Oblast of the Semipalatinsk Nuclear Test Site.

PubMed

Mitchell, Peter I; Vintró, Luis León; Omarova, Aigul; Burkitbayev, Mukhambetkali; Nápoles, Humberto Jiménez; Priest, Nicholas D

2005-06-01

The concentration of tritium has been determined in well waters, streams and atomic lakes in the Sarzhal, Tel'kem, Balapan and Degelen Mountains areas of the Semipalatinsk Test Site. The data show that levels of tritium in domestic well waters within the settlement of Sarzhal are extremely low at the present time with a median value of 4.4 Bq dm(-3) (95% confidence interval:4.1-4.7 Bq dm(-3)). These levels are only marginally above the background tritium content in surface waters globally. Levels in the atomic craters at Tel'kem 1 and Tel'kem 2 are between one and two orders of magnitude higher, while the level in Lake Balapan is approximately 12,600 Bq dm(-3). Significantly, levels in streams and test-tunnel waters sourced in the Degelen Mountains, the site of approximately 215 underground nuclear tests, are a further order of magnitude higher, being in the range 133,000--235,500 Bq dm(-3). No evidence was adduced which indicates that domestic wells in Sarzhal are contaminated by tritium-rich waters sourced in the Degelen massif, suggesting that the latter are not connected hydrologically to the near-surface groundwater recharging the Sarzhal wells. Annual doses to humans arising from the ingestion of tritium in these well waters are very low at the present time and are of no radiological significance.

Unintentional drinking-water contamination events of unknown origin: surrogate for terrorism preparedness.

PubMed

Winston, Gary; Leventhal, Alex

2008-01-01

Drinking-water is a direct conduit to many human receptors. An intentional attack (e.g. terrorism) on drinking-water systems can shock and disrupt elements of national infrastructures. We report on an unintentional drinking-water contamination event that occurred in Tel Aviv, Israel in July, 2001. Initially of unknown origin, this event involved risk management strategies used by the Ministry of Health for abating a potential public health crisis as might be envisaged of water contamination due to terrorism. In an abrupt event of unknown origin, public health officials need to be responsible for the same level of preparedness and risk communication. This is emphasized by comparison of management strategies between the Tel Aviv event and one of dire consequences that occurred in Camelford, England in 1988. From the onset of the Tel Aviv incident, the public health strategy was to employ the precautionary principle by warning residents of the affected region to not drink tap water, even if boiled. This strategy was in contrast to an earlier crisis that occurred in Camelford, England in 1988. An outcome of this event was heightened awareness that a water crisis can occur in peacetime and not only in association with terrorism. No matter how minor the contamination event or short-term the disruption of delivery of safe drinking-water, psychological, medical and public health impact could be significant.

75 FR 42611 - Energy Conservation Program for Consumer Products: Test Procedure for Microwave Ovens

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-22

... visiting the Resource Room. FOR FURTHER INFORMATION CONTACT: Mr. Wes Anderson, U.S. Department of Energy..., SW., Washington, DC 20585- 0121. Tel.: (202) 586-7335. E-mail: Wes.Anderson@ee.doe.gov . Ms...

Conversations on the habitability of worlds: The importance of volatiles

USGS Publications Warehouse

Bertaux, J.-L.; Carr, M.; Des Marais, D.J.; Gaidos, E.

2007-01-01

Our scientific forefathers discuss the interrelationships between water, climate, the atmosphere, and life on Earth and other terrestrial planets at a workshop in Nichtcha??tel, Switzerland. ?? 2007 Springer Science+Business Media B.V.

Determining the ion temperature and energy distribution in a lithium-plasma interaction test stand with a retarding field energy analyzer

NASA Astrophysics Data System (ADS)

Christenson, M.; Stemmley, S.; Jung, S.; Mettler, J.; Sang, X.; Martin, D.; Kalathiparambil, K.; Ruzic, D. N.

2017-08-01

The ThermoElectric-driven Liquid-metal plasma-facing Structures (TELS) experiment at the University of Illinois is a gas-puff driven, theta-pinch plasma source that is used as a test stand for off-normal plasma events incident on materials in the edge and divertor regions of a tokamak. The ion temperatures and resulting energy distributions are crucial for understanding how well a TELS pulse can simulate an extreme event in a larger, magnetic confinement device. A retarding field energy analyzer (RFEA) has been constructed for use with such a transient plasma due to its inexpensive and robust nature. The innovation surrounding the use of a control analyzer in conjunction with an actively sampling analyzer is presented and the conditions of RFEA operation are discussed, with results presented demonstrating successful performance under extreme conditions. Such extreme conditions are defined by heat fluxes on the order of 0.8 GW m-2 and on time scales of nearly 200 μs. Measurements from the RFEA indicate two primary features for a typical TELS discharge, following closely with the pre-ionizing coaxial gun discharge characteristics. For the case using the pre-ionization pulse (PiP) and the theta pinch, the measured ion signal showed an ion temperature of 23.3 ± 6.6 eV for the first peak and 17.6 ± 1.9 eV for the second peak. For the case using only the PiP, the measured signal showed an ion temperature of 7.9 ± 1.1 eV for the first peak and 6.6 ± 0.8 eV for the second peak. These differences illustrate the effectiveness of the theta pinch for imparting energy on the ions. This information also highlights the importance of TELS as being one of the few linear pulsed plasma sources whereby moderately energetic ions will strike targets without the need for sample biasing.

Determining the ion temperature and energy distribution in a lithium-plasma interaction test stand with a retarding field energy analyzer.

PubMed

Christenson, M; Stemmley, S; Jung, S; Mettler, J; Sang, X; Martin, D; Kalathiparambil, K; Ruzic, D N

2017-08-01

The ThermoElectric-driven Liquid-metal plasma-facing Structures (TELS) experiment at the University of Illinois is a gas-puff driven, theta-pinch plasma source that is used as a test stand for off-normal plasma events incident on materials in the edge and divertor regions of a tokamak. The ion temperatures and resulting energy distributions are crucial for understanding how well a TELS pulse can simulate an extreme event in a larger, magnetic confinement device. A retarding field energy analyzer (RFEA) has been constructed for use with such a transient plasma due to its inexpensive and robust nature. The innovation surrounding the use of a control analyzer in conjunction with an actively sampling analyzer is presented and the conditions of RFEA operation are discussed, with results presented demonstrating successful performance under extreme conditions. Such extreme conditions are defined by heat fluxes on the order of 0.8 GW m -2 and on time scales of nearly 200 μs. Measurements from the RFEA indicate two primary features for a typical TELS discharge, following closely with the pre-ionizing coaxial gun discharge characteristics. For the case using the pre-ionization pulse (PiP) and the theta pinch, the measured ion signal showed an ion temperature of 23.3 ± 6.6 eV for the first peak and 17.6 ± 1.9 eV for the second peak. For the case using only the PiP, the measured signal showed an ion temperature of 7.9 ± 1.1 eV for the first peak and 6.6 ± 0.8 eV for the second peak. These differences illustrate the effectiveness of the theta pinch for imparting energy on the ions. This information also highlights the importance of TELS as being one of the few linear pulsed plasma sources whereby moderately energetic ions will strike targets without the need for sample biasing.

Spinal Muscular Atrophy

MedlinePlus

... length SMN protein, which is critical for the maintenance of motor neurons. Muscle relaxants such as baclofen, ... Tel: 703-299-1144 Cure SMA 925 Busse Road Elk Grove Village, IL 60007 info@fsma.org ...

Contact Us | Center for Cancer Research

Cancer.gov

Program Contact Program Manager Anuradha Budhu, Ph.D. Program Manager, NCI CCR Liver Cancer Program Senior Associate Scientist, Liver Carcinogenesis Section Laboratory of Human Carcinogenesis NCI Center for Cancer Research Tel: 240-760-6837

75 FR 9184 - Federal Advisory Committee; Advisory Council on Dependents' Education; Open Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-01

... meet on April 30, 2010, in Wiesbaden, Germany. Subject to the availability of space, the meeting is... Wiesbaden, Germany; 49-611-1882-0 (phone). FOR FURTHER INFORMATION CONTACT: Ms. Leesa Rompre, tel. (703) 588...

Viral Evolution Core | FNLCR Staging

Cancer.gov

Brandon F. Keele, Ph.D. PI/Senior Principal Investigator, Retroviral Evolution Section Head, Viral Evolution Core Leidos Biomedical Research, Inc. Frederick National Laboratory for Cancer Research Frederick, MD 21702-1201 Tel: 301-846-173

76 FR 78684 - Grant Program To Assess, Evaluate and Promote Development of Tribal Energy and Mineral Resources

Federal Register 2010, 2011, 2012, 2013, 2014

2011-12-19

...) 407-0668 or email: [email protected] ; and Geothermal Energy: Bob Just, Tel: (720) 407... Development of Tribal Energy and Mineral Resources AGENCY: Bureau of Indian Affairs, Interior. ACTION: Solicitation of proposals. [[Page 78685

Mobile Text Messaging to Improve Medication Adherence and Viral Load in a Vulnerable Canadian Population Living With Human Immunodeficiency Virus: A Repeated Measures Study.

PubMed

King, Elizabeth; Kinvig, Karen; Steif, Jonathan; Qiu, Annie Q; Maan, Evelyn J; Albert, Arianne Yk; Pick, Neora; Alimenti, Ariane; Kestler, Mary H; Money, Deborah M; Lester, Richard T; Murray, Melanie Caroline Margaret

2017-06-01

Combination antiretroviral therapy (cART) as treatment for human immunodeficiency virus (HIV) infection is effective and available, but poor medication adherence limits benefits, particularly in vulnerable populations. In a Kenyan randomized controlled trial, a weekly text-messaging intervention (WelTel) improved cART adherence and HIV viral load (VL). Despite growing evidence for short message service (SMS) text-message interventions in HIV care, there is a paucity of data utilizing these interventions in marginalized or female cohorts. This study was undertaken to assess whether the standardized WelTel SMS text-message intervention applied to a vulnerable, predominantly female, population improved cART adherence and VL. We conducted a repeated measures study of the WelTel intervention in high-risk HIV-positive persons by measuring change in VL, CD4 count, and self-reported adherence 12 months before and 12 months after the WelTel intervention was introduced. Inclusion criteria included VL ≥200 copies/mL, indication for treatment, and meeting vulnerability criteria. Participants were given a mobile phone with unlimited texting (where required), and weekly check-in text messages were sent for one year from the WelTel computer platform. Clinical data were collected for control and intervention years. Participants were followed by a multidisciplinary team in a clinical setting. Outcomes were assessed using Wilcoxon signed ranks tests for change in CD4 and VL from control year to study end and mixed-effects logistic regressions for change in cART adherence and appointment attendance. A secondary analysis was conducted to assess the effect of response rate on the outcome by modeling final log 10 VL by number of responses while controlling for mean log 10 VL in the control year. Eighty-five participants enrolled in the study, but 5 withdrew (final N=80). Participants were predominantly female (90%, 72/80) with a variety of vulnerabilities. Mean VL decreased from 1098

Cushing's Syndrome

MedlinePlus

... Support and Research Foundation 60 Robbins, #12 Plymouth MA Plymouth, MA 02360 cushinfo@csrf.net http://csrf.net Tel: ... Support and Research Foundation 60 Robbins, #12 Plymouth MA Plymouth, MA 02360 cushinfo@csrf.net http://csrf. ...

Brain and Spinal Tumors

MedlinePlus

... National Home Office 250 Williams Street, NW Atlanta GA Atlanta, GA 30303-1002 http://www.cancer.org Tel: 800- ... National Home Office 250 Williams Street, NW Atlanta GA Atlanta, GA 30303-1002 http://www.cancer.org ...

Apparatus Notes.

ERIC Educational Resources Information Center

Eaton, Bruce G., Ed.

1982-01-01

Presents a technique to produce samples for x-ray diffraction studies on the Tel-X-Ometer 80 x-ray apparatus from readily available crystalline powders and discusses observations of transverse modes of an optical resonator. (SK)

15 CFR 764.4 - Reporting of violations.

Code of Federal Regulations, 2011 CFR

2011-01-01

... Enforcement, Bureau of Industry and Security,U.S. Department of Commerce, 14th Street and Constitution Avenue.... Department of Commerce, 14th Street and Constitution Avenue, N.W., Room H-6099C, Washington, D.C. 20230, Tel...

Hypersomnia

MedlinePlus

... 5885 Cumming Highway Suite 108-255 Sugar Hill GA Sugar Hill, GA 30518 http://www.hypersomniafoundation.org Tel: 844-342- ... 5885 Cumming Highway Suite 108-255 Sugar Hill GA Sugar Hill, GA 30518 http://www.hypersomniafoundation.org ...

Multidrug-Resistant Candida haemulonii and C. auris, Tel Aviv, Israel.

PubMed

Ben-Ami, Ronen; Berman, Judith; Novikov, Ana; Bash, Edna; Shachor-Meyouhas, Yael; Zakin, Shiri; Maor, Yasmin; Tarabia, Jalal; Schechner, Vered; Adler, Amos; Finn, Talya

2017-02-01

Candida auris and C. haemulonii are closely related, multidrug-resistant emerging fungal pathogens that are not readily distinguishable with phenotypic assays. We studied C. auris and C. haemulonii clinical isolates from 2 hospitals in central Israel. C. auris was isolated in 5 patients with nosocomial bloodstream infection, and C. haemulonii was found as a colonizer of leg wounds at a peripheral vascular disease clinic. Liberal use of topical miconazole and close contact among patients were implicated in C. haemulonii transmission. C. auris exhibited higher thermotolerance, virulence in a mouse infection model, and ATP-dependent drug efflux activity than C. haemulonii. Comparison of ribosomal DNA sequences found that C. auris strains from Israel were phylogenetically distinct from isolates from East Asia, South Africa and Kuwait, whereas C. haemulonii strains from different countries were closely interrelated. Our findings highlight the pathogenicity of C. auris and underscore the need to limit its spread.

A preliminary evaluation of sediment quality assessment values for freshwater ecosystems

USGS Publications Warehouse

Smith, Sherri L.; MacDonald, Donald D.; Keenleyside, Karen A.; Ingersoll, Christopher G.; Field, L. Jay

1996-01-01

Sediment quality assessment values were developed using a weight of evidence approach in which matching biological and chemical data from numerous modelling, laboratory, and field studies performed on freshwater sediments were compiled and analyzed. Two assessment values (a threshold effect level (TEL) and a probable effect level(PEL)) were derived for 23 substances, including eight trace metals, six individual polycyclic aromatic hydrocarbons (PAHs), total polychlorinated biphenyls (PCBs), and eight pesticides. The two values defined three ranges of chemical concentrations; those that were (1) rarely, (2) occasionally, and (3) frequently associated with adverse biological effects. An evaluation of the percent incidence of adverse biological effects within the three concentration ranges indicated that the reliability of the TELs (i.e., the degree to which the TELs represent concentrations within the data set below which adverse effects rarely occur) was consistently good. However, this preliminary evaluation indicated that most of the PELs were less reliable (i.e., they did not adequately represent concentrations within the data set above which adverse effects frequently occur). Nonetheless, these values were often comparable to other biological effects-based assessment values (which were themselves reliable), which increased the level of confidence that could be placed in our values. This method is being used as a basis for developing national sediment quality guidelines for freshwater systems in Canada and sediment effect concentrations as part of the Assessment and Remediation of Contaminated Sediments (ARCS) program in the Great Lakes.

Differences in methylphenidate abuse rates among methadone maintenance treatment patients in two clinics.

PubMed

Peles, Einat; Schreiber, Shaul; Linzy, Shirley; Domani, Yoav; Adelson, Miriam

2015-07-01

Methylphenidate, an amphetamine-like prescription medication for attention deficit hyperactivity disorder (ADHD) was suspected as being abused among methadone maintenance treatment (MMT) patients. We tested its presence in the routine urine monitoring of all patients in both Tel Aviv and Las Vegas MMT clinics. Data on demographic and addiction history, ADHD (Wender Utah Rating Scale), cognitive impairment (Mini Mental State Exam), and lifetime DSM-IV-TR psychiatric diagnosis from admission were retrieved, and retention following 6 months. None of the 190 patients in Las Vegas tested positive for methylphenidate, while 14.7% (45/306) did in Tel Aviv. Abusers were less educated (p = 0.01), had higher ADHD scores (p = 0.02), lower cognitive scores (p = 0.05), and a higher benzodiazepine (BDZ) abuse rate (p < 0.0005), with no difference in age, gender, duration in MMT, cannabis, opiates, and cocaine abuse and infectious disease. Of the methylphenidate abuse 42.2% have take-home methadone dose privileges. Not like opiate use, being methylphenidate positive did not relate to 6-months retention. Compared to Tel Aviv, Las Vegas patients were more educated, with lower BDZ, and cocaine abuse. The greater abuse of methylphenidate among ADHD subjects might indicate their using it as self-medication, raising a possible indication for its prescription for that subgroup of MMT patients. The high rate of methylphenidate abuse in Israel needs future study. Copyright © 2015 Elsevier Inc. All rights reserved.

[Chimeric antigen receptors T cells in treatment of a relapsed pediatric acute lymphoblastic leukemia, relapse after allogenetic hematopoietic stem cell transplantation: case report and review of literature review].

PubMed

Zuo, Yingxi; Wang, Jingbo; Lu, Aidong; Jia, Yueping; Wu, Jun; Dong, Lujia; Chang, Lungji; Zhang, Leping

2016-02-01

To evaluate the safety and efficacy of chimeric antigen receptors T cells (CAR-T) in childhood acute B lymphoblastic leukemia (B-ALL). A relapsed B-ALL child after allogeneic hematopoietic stem cell transplantation (allo-HSCT) was treated with CAR-T, and the related literatures were reviewed. An 11-year-old girl with TEL-AML1 fusion gene positive BALL who suffered a bone marrow relapse 28 months after remission from conventional chemotherapy. During the second remission, the patient received haploidentical allo-HSCT. She relapsed with detectable TEL-AML1 fusion gene even after chemotherapy and donor leukocyte infusions. She received an experimental donor-derived fourth generation CD19 CAR-T therapy. After infusion of 1 × 10(6)/kg CAR-T cells, she experienced only mild or moderate cytokine-release syndrome and the minimal residual disease turned negative. Then three maintenance of CAR-T cell infusions [(0.83-1.65)×10(6)/kg] was administered, and the disease-free survival had lasted for 10 months. However, the TEL-AML1 copies in her blood still increased and she died with leukemia relapse after additional CAR-T cell infusion. Treatment of relapsed B-ALL with the fourth generation CAR-T cells directed against CD19 was effective and safe. CAR-T therapy is a novel therapeutic approach that could be useful for patients with relapsed and refractory B-ALL who have failed all other treatment options.

NATO Study of Mental Health Training in Army Recruits

DTIC Science & Technology

2011-04-01

Reed Army Institute of Research Nachrichten Kaserne, Karlsruherstrasse 144, 06126 Heidelberg, Germany Tel: +49-6221-172626 Fax:+49-6221-173170 e...Institute of Research Nachrichten Kaserne, Karlsruherstrasse 144, 06126 Heidelberg, Germany 8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING

YSAR: a compact low-cost synthetic aperture radar

NASA Astrophysics Data System (ADS)

Thompson, Douglas G.; Arnold, David V.; Long, David G.; Miner, Gayle F.; Karlinsey, Thomas W.; Robertson, Adam E.

1997-09-01

The Brigham Young University Synthetic Aperture Radar (YSAR) is a compact, inexpensive SAR system which can be flown on a small aircraft. The system has exhibited a resolution of approximately 0.8 m by 0.8 m in test flights in calm conditions. YSAR has been used to collect data over archeological sites in Israel. Using a relatively low frequency (2.1 GHz), we hope to be able to identify walls or other archeological features to assist in excavation. A large data set of radar and photographic data have been collected over sites at Tel Safi, Qumran, Tel Micnah, and the Zippori National Forest in Israel. We show sample images from the archeological data. We are currently working on improved autofocus algorithms for this data and are developing a small, low-cost interferometric SAR system (YINSAR) for operation from a small aircraft.

A Very Liquid Heaven: An exhibit exploring the human perception of stars

NASA Astrophysics Data System (ADS)

Crone, M. M.

2004-12-01

This year the Tang Teaching Museum and Art Gallery at Skidmore College is showing an exhibit about the human perception of stars, accompanied by a catalog, a speaker series, and an outreach program. The exhibit includes historical documents and atlases as well as work by a variety of artists and scientists. A Very Liquid Heaven opened with a performance of George Crumb's musical piece Makrokosmos III surrounded by original dance, theater, and video art. The title of the exhibit is inspired by Rene Descartes' 1644 text Principles of Philosophy, where he describes the earth as "surrounded on all sides by a very liquid heaven." Although Isaac Newton's laws of mechanics and gravity later discredited his specific hypothesis, in a sense Descartes was correct: astronomy has indeed revealed stars not as hard, fixed objects, but as pulsing plasmas, and interstellar space not as a pure void, but as diffuse clouds of atoms and molecules. This exhibit is made possible with support from Beverly P. and R. Lawrence St. Clair, the Nathalie Potter Voorhees '45 Memorial fund, and the Friends of the Tang.

The Dynamics of Large-Amplitude Motion in Energized Molecules

DOE Office of Scientific and Technical Information (OSTI.GOV)

Perry, David S.

2016-05-27

Chemical reactions involve large-amplitude nuclear motion along the reaction coordinate that serves to distinguish reactants from products. Some reactions, such as roaming reactions and reactions proceeding through a loose transition state, involve more than one large-amplitude degree of freedom. Because of the limitation of exact quantum nuclear dynamics to small systems, one must, in general, define the active degrees of freedom and separate them in some way from the other degrees of freedom. In this project, we use large-amplitude motion in bound model systems to investigate the coupling of large-amplitude degrees of freedom to other nuclear degrees of freedom. Thismore » approach allows us to use the precision and power of high-resolution molecular spectroscopy to probe the specific coupling mechanisms involved, and to apply the associated theoretical tools. In addition to slit-jet spectra at the University of Akron, the current project period has involved collaboration with Michel Herman and Nathalie Vaeck of the Université Libre de Bruxelles, and with Brant Billinghurst at the Canadian Light Source (CLS).« less

41 CFR 102-117.140 - What is cargo preference?

Code of Federal Regulations, 2013 CFR

2013-07-01

..., Office of Cargo Preference, 1200 New Jersey Ave., SE., Washington, DC 20590, http://marad.dot.gov/. Tel. 1-800-987-3524. E-mail: [email protected]gov. [65 FR 60060, Oct. 6, 2000; 65 FR 81405, Dec. 26, 2000...

41 CFR 102-117.140 - What is cargo preference?

Code of Federal Regulations, 2014 CFR

2014-01-01

..., Office of Cargo Preference, 1200 New Jersey Ave., SE., Washington, DC 20590, http://marad.dot.gov/. Tel. 1-800-987-3524. E-mail: [email protected]gov. [65 FR 60060, Oct. 6, 2000; 65 FR 81405, Dec. 26, 2000...

41 CFR 102-117.140 - What is cargo preference?

Code of Federal Regulations, 2011 CFR

2011-01-01

..., Office of Cargo Preference, 1200 New Jersey Ave., SE., Washington, DC 20590, http://marad.dot.gov/. Tel. 1-800-987-3524. E-mail: [email protected]gov. [65 FR 60060, Oct. 6, 2000; 65 FR 81405, Dec. 26, 2000...

41 CFR 102-117.140 - What is cargo preference?

Code of Federal Regulations, 2012 CFR

2012-01-01

..., Office of Cargo Preference, 1200 New Jersey Ave., SE., Washington, DC 20590, http://marad.dot.gov/. Tel. 1-800-987-3524. E-mail: [email protected]gov. [65 FR 60060, Oct. 6, 2000; 65 FR 81405, Dec. 26, 2000...

75 FR 31775 - Draft National Pollutant Discharge Elimination System (NPDES) Pesticide General Permit for Point...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-04

... Faulk, EPA Headquarters, Office of Water, Office of Wastewater Management at tel.: 202-564-0768 or e... activities. Resource management parties 924110 Government (includes State departments Administration of... Solid in the regulation, State Waste Management administration, environmental agencies, and Programs...

Technology Enhanced Learning in Programming Courses--International Perspective

ERIC Educational Resources Information Center

Ivanovic, Mirjana; Xinogalos, Stelios; Pitner, Tomáš; Savic, Miloš

2017-01-01

Technology enhanced learning (TEL) is increasingly influencing university education, mainly in overcoming disadvantages of direct instruction teaching approaches, and encouraging creativity, problem solving and critical thinking in student-centered, interactive learning environments. In this paper, experiences from object-oriented programming…

15 CFR 730.8 - How to proceed and where to get help.

Code of Federal Regulations, 2010 CFR

2010-01-01

... part 772 of the EAR lists definitions used. (b) Why the EAR are so detailed. Some people will find the... Street, Suite 725, San Jose, CA 95113, Tel: (408) 998-8806, Fax: (408) 998-8677. [61 FR 12734, Mar. 25...

Expression of Concern

NASA Astrophysics Data System (ADS)

Delvaux, Damien

2016-08-01

This is a note of a temporary expression of concern related to the publication titled, "Sapphirine and fluid inclusions in Tel Thanoun mantle xenoliths, Syria" by Ahmad Bilal, which appeared in Journal of African Earth Sciences, 116 (2016) 105-113.

41 CFR 102-117.140 - What is cargo preference?

Code of Federal Regulations, 2010 CFR

2010-07-01

... Office of Cargo Preference 400 7th Street, SW. Washington, DC 20590 http://www.marad.dot.gov/ Tel. 1-800-9US-FLAG e-mail: [email protected]gov [65 FR 60060, Oct. 6, 2000; 65 FR 81405, Dec. 26, 2000] ...

Nuclear Weapons R&D Organiziations in Nine Nations

DTIC Science & Technology

2009-03-16

Sorek (alternative transliteration: Soreq) south of Tel Aviv and at the larger Center for Nuclear Research in the Negev south of Dimona. According to...Utilization Institute; (7) Neutron Physics Institute; (8) Reactor Design Institute; (9) Nuclear Electromagnetics Institute; (10) Radiation Protection

Nuclear Weapons R&D Organizations in Nine Nations

DTIC Science & Technology

2009-03-16

Sorek (alternative transliteration: Soreq) south of Tel Aviv and at the larger Center for Nuclear Research in the Negev south of Dimona. According to...Utilization Institute; (7) Neutron Physics Institute; (8) Reactor Design Institute; (9) Nuclear Electromagnetics Institute; (10) Radiation Protection

Gender and the Structure and Salience of Values: An Example from Israeli Youth.

ERIC Educational Resources Information Center

Maslovaty, Nava; Dor-Shav, Zecharia

1990-01-01

Male and female eleventh grade students from 14 schools in Tel Aviv were tested to determine the effect of gender and other factors on values and value judgments. No predominating factor was found, although gender effect could be quantified. (DM)

ORFEUS spectroscopy of the O BT VI lines in symbiotic stars and the Raman scattering process

NASA Astrophysics Data System (ADS)

Schmid, H. M.; Krautter, J.; Appenzeller, I.; Barnstedt, J.; Dumm, T.; Fromm, A.; Gölz, M.; Grewing, M.; Gringel, W.; Haas, C.; Hopfensitz, W.; Kappelmann, N.; Krämer, G.; Lindenberger, A.; Mandel, H.; Mürset, U.; Schild, H.; Schmutz, W.; Widmann, H.

1999-08-01

We present orfeus spectra of the O vi lambda lambda 1032,1038 emission lines in the symbiotic stars AG Dra, V1016 Cyg, RR Tel, CD-43(deg) 14304, AG Peg and Z And. The O vi emission lines can convert into broad and highly polarized emission lines at lambda 6825 and lambda 7082 in a Raman scattering process by neutral hydrogen. From a comparison of direct and Raman scattered radiation we extract new information on the scattering geometry in symbiotic systems. The nebular O vi emission lines are in all objects redshifted by about +40 km s(-1) . This can be explained as a radiative line transfer effect in a slowly expanding emission region. A comparable redshift is measured in the Raman scattered O vi lines. In AG Peg the O vi emissions show beside a narrow nebular line a broad component from a fast stellar wind outflow. Many interstellar absorption lines of molecular hydrogen are detected, particularly near the O vi lambda 1038 component. With model calculations we investigate their impact on the O vi lines. From the dereddened line fluxes of the direct and Raman scattered O vi lines we derive the scattering efficiency, which is defined as photon flux ratio N_Raman/N_O VI. The efficiencies derived for RR Tel, V1016 Cyg and Z And indicate that about 30% of the released O vi lambda 1032 photons interact with the neutral scattering region. The efficiencies for AG Dra and CD-43(deg14304) are much higher, which may suggest that the O vi nebulosity is embedded in a H(0) -region. The D-type system RR Tel shows strong line profile differences between the direct O vi emission, which is single-peaked, and the Raman scattered emission, which is double-peaked. This indicates that the neutral scattering region in RR Tel ``sees'' different O vi line profiles, implying that the O vi nebulosity is far from spherically symmetric. In a tentative model we suggest for RR Tel an O vi flow pattern where material streams from the cool giant towards the hot component, which further

Interactive Two-Way mHealth Interventions for Improving Medication Adherence: An Evaluation Using The Behaviour Change Wheel Framework

PubMed Central

Amico, K Rivet; Atkins, Lou; Lester, Richard T

2018-01-01

Background Medication adherence is an important but highly complex set of behaviors, which for life-threatening and infectious diseases such as HIV carry critical consequences for individual and public health. There is growing evidence that mobile phone text messaging interventions (mHealth) connecting providers with patients positively impact medication adherence, particularly two-way engagement platforms that require bidirectional communication versus one-way in which responses are not mandatory. However, mechanisms of action have not been well defined. The Behavior Change Wheel is a comprehensive framework for behavior change that includes an all-encompassing model of behavior known as Capability Opportunity Motivation-Behavior and is complemented by a taxonomy of behavior change techniques. Evaluating mHealth interventions for medication adherence using these tools could provide useful insights that may contribute to optimizing their integration into the healthcare system and successful scaling-up. Objective This study aimed to help address the current knowledge gap regarding how two-way mHealth interventions for medication adherence may work by applying the Behavior Change Wheel to characterize WelTel: an interactive digital health outreach platform with robust evidence for improving adherence to antiretroviral therapy. Methods To characterize how WelTel may promote medication adherence, we applied the Behavior Change Wheel to systematically (1) generate a behavioral diagnosis through mapping known antiretroviral therapy adherence barriers onto the Capability Opportunity Motivation-Behavior model of behavior, (2) specify the behavior change techniques that WelTel delivers, (3) link identified behavior change techniques to corresponding intervention functions of the Behavior Change Wheel, and (4) connect these behavior change techniques and intervention functions to respective Capability Opportunity Motivation-Behavior influences on behavior to determine

Risk factors in road crossing among elderly pedestrians and readiness to adopt safe behavior in socio-economic comparison.

PubMed

Rosenbloom, Tova; Sapir-Lavid, Yael; Perlman, Amotz

2016-08-01

This research examines the Health Promotion Behavior (HPB) models regarding elderly pedestrians' behaviors and attitudes. We studied cognitive-psychological variables, such as risk estimation, self-efficacy and demographic variables and compared elderly pedestrians' attitudes and behaviors in a city with higher socio-economic level (Tel Aviv) versus a city with low socio-economic level (Beer Sheva). We expected to find more problematic behaviors among elderly pedestrians in the low socio-economic city compared to the high socio-economic city, and also less feeling of self-efficacy, and lessened awareness of the risks, that leads to lessened willingness to adopt preventive behaviors. The research was conducted in two studies. The first study was based on observations on 2591 pedestrians in six similar crosswalks in both cities. It revealed that pedestrians in the high socio-economic city demonstrated safer road crossing patterns than in the low socio-economic city and that elderly pedestrians reveal safer crossing patterns than younger pedestrians. We found an interaction of location and age due to greater gap of safe behaviors of elderly and young pedestrians in the high socio-economic city than in the low socio-economic city. In Tel Aviv elderly adhere to the crossing rules much more than the young while in Beer Sheva elderly and young people are almost similar in their crossing patterns. The second study used questionnaires that have been completed by 143 elderly in both cities. The questionnaires referred to (a) demographic variables such as gender, age, marital status, education, socio-economic level, (b) variables related to the affiliation to the main culture such as migration, date of migration, knowledge in Hebrew (local language) and connectivity to media and (c) cognitive as well as psychological variables related to the decline to adopt healthy behaviors based on Schwarzer and Fuchs (1995). This part also indicated that elderly in Tel Aviv have higher

Effect of Urea on G-Quadruplex Stability.

PubMed

Aslanyan, Lusine; Ko, Jordan; Kim, Byul G; Vardanyan, Ishkhan; Dalyan, Yeva B; Chalikian, Tigran V

2017-07-13

G-quadruplexes represent a class of noncanonical nucleic acid structures implicated in transcriptional regulation, cellular function, and disease. An understanding of the forces involved in stabilization and destabilization of the G-quadruplex conformation relative to the duplex or single-stranded conformation is a key to elucidating the biological role of G-quadruplex-based genomic switches and the quest for therapeutic means for controlled induction or suppression of a G-quadruplex at selected genomic loci. Solute-solvent interactions provide a ubiquitous and, in many cases, the determining thermodynamic force in maintaining and modulating the stability of nucleic acids. These interactions involve water as well as water-soluble cosolvents that may be present in the solution or in the crowded environment in the cell. We present here the first quantitative investigation of the effect of urea, a destabilizing cosolvent, on the conformational preferences of a G-quadruplex formed by the telomeric d[A(G 3 T 2 A) 3 G 3 ] sequence (Tel22). At 20 mM NaCl and room temperature, Tel22 undergoes a two-state urea-induced unfolding transition. An increase in salt mitigates the deleterious effect of urea on Tel22. The urea m-value of Tel22 normalized per change in solvent-accessible surface area, ΔS A , is similar to those for other DNA and RNA structures while being several-fold larger than that of proteins. Our results suggest that urea can be employed as an analytical tool in thermodynamic characterizations of G-quadruplexes in a manner similar to the use of urea in protein studies. We emphasize the need for further studies involving a larger selection of G-quadruplexes varying in sequence, topology (parallel, antiparallel, hybrid), and molecularity (monomolecular, bimolecular, tetramolecular) to outline the advantages and the limits of the use of urea in G-quadruplex studies. A deeper understanding of the effect of solvent and cosolvents on the differential stability of the

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15 CFR Supplement No. 3 to Part 730 - Other U.S. Government Departments and Agencies With Export Control Responsibilities

Code of Federal Regulations, 2012 CFR

2012-01-01

.... Nuclear Materials and Equipment * Nuclear Regulatory Commission, Office of International Programs, Tel. (301) 415-2344, Fax: (301) 415-2395. 10 CFR part 110. Nuclear Technologies and Services Which Contribute to the Production of Special Nuclear Material (Snm). Technologies Covered Include Nuclear Reactors...

[In process

PubMed

Thinard-Morel, Janine

2016-12-01

At the end of the Middle Ages, in 1492, the Hôtel-Dieu de Paris was still and establishment of charity intended to receive thepoor which came there to find a shelter and some food. Three centuries later, just before the French Revolution, it became an establishment of care mainly destined to receive the patients, to feed them, take care of them and if possible cure them. This medicalization of the Hôtel-Dieu de Paris is related to the progressive emergence of the medical function, which resulted in the creation and the development of a doctor's and surgeon's profession, but also in the development of the apothecary and its drugs. In this context, the diet plays a central part, because it happens to supplies. It would not be until the eve of the French Revolution that it would be integrated in the doctor's prescription and became a dietetic item.

Budding Yeast ATM/ATR Control Meiotic Double-Strand Break (DSB) Levels by Down-Regulating Rec114, an Essential Component of the DSB-machinery

PubMed Central

Carballo, Jesús A.; Panizza, Silvia; Serrentino, Maria Elisabetta; Johnson, Anthony L.; Geymonat, Marco; Borde, Valérie; Klein, Franz; Cha, Rita S.

2013-01-01

An essential feature of meiosis is Spo11 catalysis of programmed DNA double strand breaks (DSBs). Evidence suggests that the number of DSBs generated per meiosis is genetically determined and that this ability to maintain a pre-determined DSB level, or “DSB homeostasis”, might be a property of the meiotic program. Here, we present direct evidence that Rec114, an evolutionarily conserved essential component of the meiotic DSB-machinery, interacts with DSB hotspot DNA, and that Tel1 and Mec1, the budding yeast ATM and ATR, respectively, down-regulate Rec114 upon meiotic DSB formation through phosphorylation. Mimicking constitutive phosphorylation reduces the interaction between Rec114 and DSB hotspot DNA, resulting in a reduction and/or delay in DSB formation. Conversely, a non-phosphorylatable rec114 allele confers a genome-wide increase in both DSB levels and in the interaction between Rec114 and the DSB hotspot DNA. These observations strongly suggest that Tel1 and/or Mec1 phosphorylation of Rec114 following Spo11 catalysis down-regulates DSB formation by limiting the interaction between Rec114 and DSB hotspots. We also present evidence that Ndt80, a meiosis specific transcription factor, contributes to Rec114 degradation, consistent with its requirement for complete cessation of DSB formation. Loss of Rec114 foci from chromatin is associated with homolog synapsis but independent of Ndt80 or Tel1/Mec1 phosphorylation. Taken together, we present evidence for three independent ways of regulating Rec114 activity, which likely contribute to meiotic DSBs-homeostasis in maintaining genetically determined levels of breaks. PMID:23825959

Nondamaging Retinal Laser Therapy: Rationale and Applications to the Macula.

PubMed

Lavinsky, Daniel; Wang, Jenny; Huie, Philip; Dalal, Roopa; Lee, Seung Jun; Lee, Dae Yeong; Palanker, Daniel

2016-05-01

Retinal photocoagulation and nondamaging laser therapy are used for treatment of macular disorders, without understanding of the response mechanism and with no rationale for dosimetry. To establish a proper titration algorithm, we measured the range of tissue response and damage threshold. We then evaluated safety and efficacy of nondamaging retinal therapy (NRT) based on this algorithm for chronic central serous chorioretinopathy (CSCR) and macular telangiectasia (MacTel). Retinal response to laser treatment below damage threshold was assessed in pigmented rabbits by expression of the heat shock protein HSP70 and glial fibrillary acidic protein (GFAP). Energy was adjusted relative to visible titration using the Endpoint Management (EpM) algorithm. In clinical studies, 21 eyes with CSCR and 10 eyes with MacTel were treated at 30% EpM energy with high spot density (0.25-diameter spacing). Visual acuity, retinal and choroidal thickness, and subretinal fluid were monitored for 1 year. At 25% EpM energy and higher, HSP70 was expressed acutely in RPE, and GFAP upregulation in Müller cells was observed at 1 month. Damage appeared starting at 40% setting. Subretinal fluid resolved completely in 81% and partially in 19% of the CSCR patients, and visual acuity improved by 12 ± 3 letters. Lacunae in the majority of MacTel patients decreased while preserving the retinal thickness, and vision improved by 10 letters. Heat shock protein expression in response to hyperthermia helps define the therapeutic window for NRT. Lack of tissue damage enables high-density treatment to boost clinical efficacy, therapy in the fovea, and retreatments to manage chronic diseases.

Sodium alginate as a potential carrier in solid dispersion formulations to enhance dissolution rate and apparent water solubility of BCS II drugs.

PubMed

Borba, Paola Aline Amarante; Pinotti, Marihá; de Campos, Carlos Eduardo Maduro; Pezzini, Bianca Ramos; Stulzer, Hellen Karine

2016-02-10

The solid dispersion technique is the most effective method for improving the dissolution rate of poorly water-soluble drugs, however it depends on a suitable carrier selection. The work explored the use of the biopolymer sodium alginate (SA) as a potential carrier in solid dispersions (SD). The data demonstrated that SA was able to improve the biopharmaceutical properties of the BCS II drug telmisartan (TEL) of low solubility even using relative small drug:polymer ratio. A solid state grinding process was used to prepare the solid dispersions (SD) during 45 min. The SD were prepared in different proportions of drug and carrier of 1:1, 1:3, 1:5, 1:7 and 1:9 (mass/mass). DSC, XRPD, FTIR and Raman confirmed the presence of molecular interactions between TEL and the carrier. FTIR supports the presence of hydrogen bonds between TEL and the carrier. SD_1:5, SD_1:7 and SD_1:9 enhanced the dissolution rate of the drug releasing more than 80% of the drug in just 30 min (83%, 84% and 87%). The the t-test results demonstrated equal dissolution efficiency values for SD_1:7 and Micardis(®), however the similarity (f2) and difference (f1) fit factors showed that the SD and Micardis(®) are statistically different. The physical stability studies demonstrated that SD using sodium alginate as a carrier remained unchanged during the period of 90 days at room temperature, showing that the sodium alginate acts as a good anti plasticizer agent, preventing the drug recrystallization. Copyright © 2015 Elsevier Ltd. All rights reserved.

CORRELATION OF CLINICAL AND STRUCTURAL PROGRESSION WITH VISUAL ACUITY LOSS IN MACULAR TELANGIECTASIA TYPE 2: MacTel Project Report No. 6-The MacTel Research Group.

PubMed

Peto, Tunde; Heeren, Tjebo F C; Clemons, Traci E; Sallo, Ferenc B; Leung, Irene; Chew, Emily Y; Bird, Alan C

2018-01-01

To evaluate progression of macular telangiectasia Type 2 lesions and their correlation with visual acuity. An international multicenter prospective study with annual examinations including best-corrected visual acuity (BCVA), fundus photography, fluorescein angiography, and optical coherence tomography images graded centrally. Mixed models were used to estimate progression rates, and a generalized linear model to compute the relative risk of BCVA loss, loss of ellipsoid zone (EZ) reflectivity, development of pigment plaques, or neovascularization. One thousand and fourteen eyes of 507 participants were followed for 4.2 ± 1.6 years. Best-corrected visual acuity decreased 1.07 ± 0.05 letters (mean ± SE) per year. Of all eyes, 15% lost ≥15 letters after 5 years. Of the eyes without EZ loss, 76% developed a noncentral loss. Of the eyes with noncentral loss, 45% progressed to central EZ loss. The rate of BCVA loss in eyes with noncentral EZ loss at baseline was similar to eyes without EZ loss. The rate of BCVA loss was significantly higher in eyes with central EZ loss at baseline (-1.40 ± 0.14 letters, P < 0.001). Ellipsoid zone loss is frequently found in macular telangiectasia Type 2 and is an important structural component reflecting visual function. Its presence in the fovea significantly correlates with worse visual prognosis.

75 FR 61574 - Unblocking of Specially Designated Nationals and Blocked Persons Pursuant To the Foreign...

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2010-10-05

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AMMPHS Trial Report CFB Valcartier, 28 September to 9 October 2009 (Compte Rendu D’Essais pour le AMMPHS BFC Valcartier du 28 Septembre au 9 Octobre 2009)

DTIC Science & Technology

2010-03-01

14 FIGURE 18: TUNNEL AND ROPE CLIMB...15 Tunnel and Rope Climb: Participants were required to run through a tunnel and ascend a rope ladder at the end; Figure 18: Tunnel and Rope...de la massagerie tels que PDA, telephones intelligents, Blackberry , etc. Note

Aeronautical Wind Tunnels, Europe and Asia

DTIC Science & Technology

2006-02-01

User Fees Contact Information Dr. Surjatin Wiriadidjaja, UPT-LAGG, BPP Teknologi, Puspiptek, Serpong, Tangerang 15310, Indonesia. Tel: (62) 21 756...of the tunnel, FFA T1500 Transonic Wind Tunnel Circuit (Sweden) manufactured by The Swedish Defense Research Agency (FOI). 2.4 m Transonic Wind

US Policies toward Tehran: Redefining Counterproliferation for the Twenty-First Century

DTIC Science & Technology

2011-01-01

latent weapons power, purposefully not constructing an explicit, fully weaponized arsenal, but rather cultivating and maintaining a hedged nuclear...decisively dropping the popular but empirically dubious assump­ tion that Iran’s primary intent is to put mushroom clouds over Tel Aviv and Washington as

The Impact of Culture: Communicating with Iran

DTIC Science & Technology

2009-03-01

respect to their dealings.48 American business/negotiating philosophy is very simple; make as much money or profit as you can in the shortest amount of...Behavior, Conference Report (Tel Aviv: Institute for Policy and Strategy, Interdisciplinary Center Herzliya Lauder School of Government, Diplomacy and

Cross-Linguistic Cognate Production in Spanish-English Bilingual Children with and without Specific Language Impairment

ERIC Educational Resources Information Center

Grasso, Stephanie M.; Peña, Elizabeth D.; Bedore, Lisa M.; Hixon, J. Gregory; Griffin, Zenzi M.

2018-01-01

Purpose: Bilinguals tend to produce cognates (e.g., "telephone" in English and "teléfono" in Spanish) more accurately than they produce noncognates ("table"/"mesa"). We tested whether the same holds for bilingual children with specific language impairment (SLI). Method: Participants included Spanish-English…

75 FR 51258 - Boott Hydropower, Inc.; Eldred L Field Hydroelectric Facility Trust; Notice of Application for...

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2010-08-19

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 2790-055] Boott Hydropower... Hydropower, Inc. and Eldred L Field Hydroelectric Facility Trust. e. Name of Project: Lowell Hydroelectric... Affairs Coordinator, Boott Hydropower, Inc., One Tech Drive, Suite 220, Andover, MA 01810. Tel: (978) 681...

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Accommodating the Newfound Strategic Importance of Educational Technologists within Higher Education: A Critical Literature Review

ERIC Educational Resources Information Center

Shurville, Simon; Browne, Tom; Whitaker, Marian

2009-01-01

Purpose: Educational technologists make significant contributions to the development, organisational embedding and service provision of technology-enhanced learning (TEL) environments, which are key enablers for mass access to flexible higher education (HE). Given the increasing centrality of this role, it is advocated that institutions…

Specification Technology Guidebook.

DTIC Science & Technology

1985-08-01

1. General Aspects A. Identification JSD - Jackson System Development -. Michael Jackson Systems Limited 17 Conduit Street London, England WIROTD Tel...USER MANAGER ORGANIZATION ə X _ _ _ _ 1-3__ 3-6 X > 6 _ _ D. Primary Source of Document ation Michael Jackson Systems Limited Also see: References

U.S. EPA, Pesticide Product Label, KERNEL GUARD, 03/01/1989

EPA Pesticide Factsheets

2011-04-21

... ". . • clot.Jai... ..d eII., ... ... P ... _ol oloUai •• _n 4_ing u_ ••• t.... l •• n~'" •• p.,. .. t.el~ .. •. I,.oe hou"'old art.iol.o. Clot..bi....4 protoct.1". "YA~"" ta .. ...

Venus within ESA probe reach

NASA Astrophysics Data System (ADS)

2006-03-01

Venus Express mission controllers at the ESA Space Operations Centre (ESOC) in Darmstadt, Germany are making intensive preparations for orbit insertion. This comprises a series of telecommands, engine burns and manoeuvres designed to slow the spacecraft down from a velocity of 29000 km per hour relative to Venus, just before the first burn, to an entry velocity some 15% slower, allowing the probe to be captured into orbit around the planet. The spacecraft will have to ignite its main engine for 50 minutes in order to achieve deceleration and place itself into a highly elliptical orbit around the planet. Most of its 570 kg of onboard propellant will be used for this manoeuvre. The spacecraft’s solar arrays will be positioned so as to reduce the possibility of excessive mechanical load during engine ignition. Over the subsequent days, a series of additional burns will be done to lower the orbit apocentre and to control the pericentre. The aim is to end up in a 24-hour orbit around Venus early in May. The Venus orbit injection operations can be followed live at ESA establishments, with ESOC acting as focal point of interest (see attached programme). In all establishments, ESA specialists will be on hand for interviews. ESA TV will cover this event live from ESOC in Darmstadt. The live transmission will be carried free-to-air. For broadcasters, complete details of the various satellite feeds are listed at http://television.esa.int. The event will be covered on the web at venus.esa.int. The website will feature regular updates, including video coverage of the press conference and podcast from the control room at ESA’s Operations Centre. Media representatives wishing to follow the event at one of the ESA establishments listed below are requested to fill in the attached registration form and fax it back to the place of their choice. For further information, please contact: ESA Media Relations Division Tel : +33(0)1.53.69.7155 Fax: +33(0)1.53.69.7690 Venus Express

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2013-04-18

... Designated Nationals and Blocked Persons (``SDN List''). DATES: The removal of this individual from the SDN... 20220, tel.: 202/622-2490. SUPPLEMENTARY INFORMATION: Electronic and Facsimile Availability The SDN List... determined that this individual should be removed from the SDN List. Individual 1. UMAR, Madhat Mursi Al...

Evaluation and Management of Combat-Related Spinal injuries: A Review Based on Recent Experiences

DTIC Science & Technology

2012-01-01

Piedras St, El Paso, TX 79920, USA bIntegrated Department of Orthopaedic Surgery and Rehabilitation, Walter Reed National Military Medical Center...Surgery, 115th Combat Support Hospital and William Beaumont Army Medical Center, 5005 N. Piedras St, El Paso, TX 79920, USA. Tel.: (330) 329 2594. E

75 FR 22153 - Grant Program To Assess, Evaluate and Promote Development of Tribal Energy and Mineral Resources

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... (Oil, Natural Gas, Coal): Bob Just, Tel: (720) 407-0611, e-mail: [email protected] ; Renewable Energy... and market studies. Energy includes conventional energy resources (such as oil, gas, coal, uranium, and coal bed gas) and renewable energy resources (such as wind, solar, biomass, hydro and geothermal...

Performance Art at the Campusphere: Pedagogical Experiments On-Site

ERIC Educational Resources Information Center

Ben-Shaul, Daphna

2018-01-01

Following a unique practice and research laboratory entitled "Performance: Site/Self" that took place in 2013-2015, this article discusses the implementation of performance art at an academic site--the Tel Aviv University campus. This pedagogical and artistic initiative, characterised by the transgressive pedagogy of performance art…

75 FR 58356 - Mission Statement for Executive-Led Trade Mission to Jordan and Israel

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2010-09-24

..., geothermal energy, and agro-ecology. The Israel Ministry of National Infrastructures Web site, http://www.mni... and Tel-Aviv, Israel. A stop in Eilat, Israel, for companies involved in the renewable energies sector..., pollution control, and water and wastewater treatment. Renewable energies (solar, wind, biogas), energy...

What's the Matter with "Technology-Enhanced Learning"?

ERIC Educational Resources Information Center

Bayne, Sian

2015-01-01

In recent years, "technology-enhanced learning", or "TEL", has become a widely accepted term in the UK and Europe for describing the interface between digital technology and higher education teaching, to a large extent taking the place of other recently popular terminologies such as "e-learning", "learning…

Designing Nordic Technology-Enhanced Learning

ERIC Educational Resources Information Center

Cerratto-Pargman, Teresa; Jarvela, Sanna M.; Milrad, Marcelo

2012-01-01

The latest developments of information and communication technologies (ICT) and its large penetration in different sectors of our society pose new challenges and demands in the field of education. This special issue entitled "Designing Nordic technology-enhanced learning (TEL)", presents and discusses how researchers in the Nordic…

U.S. EPA, Pesticide Product Label, DUAL 8E HERBICIDE, 07/25/1988

EPA Pesticide Factsheets

2011-04-13

... J The peshcode IIIfIKIIOII pope"" muSI t'e'l :o"'t'''e .... 'OIw' •• lo (,I ;}".I,IJE pIUS d". "''t>' " .. I·e·at> .... ... (II 2 pts ."or9 ...

An Application of Course Scheduling in the Brazilian Air Force

DTIC Science & Technology

2012-03-01

LA - lnstituto de Logistic ada Forc;;a Aerea Brasileira- Av Monteiro Lobato 5335- Guarulhos - SP - Brazil •Tel (55 ) 11 -64652109 Email julio inb...February, 2005, from http://www.sc.ehu.es/ccwbayes/docencia/mmcc/docs/ lecturas -heuristicos- optimizacion/TimetablingbyGAs.pdf, accessed on 10th

Shaping the Future of Learning Using the Student Voice: We're Listening but Are We Hearing Clearly?

ERIC Educational Resources Information Center

Meadows, Chris; Soper, Kate; Cullen, Rod; Wasiuk, Catherine; McAllister-Gibson, Colin; Danby, Phil

2016-01-01

Student voice data is a key factor as Manchester Metropolitan University strives to continually improve institutional technology enhanced learning (TEL) infrastructure. A bi-annual Institutional Student Survey enables students to communicate their experience of learning, teaching and assessment on programmes and specific units studied. Each cycle…

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ruzic, David

The Thermoelectric-Driven Liquid-Metal Plasma-Facing Structures (TELS) project was able to establish the experimental conditions necessary for flowing liquid metal surfaces in order to be utilized as surfaces facing fusion relevant energetic plasma flux. The work has also addressed additional developments along with progressing along the timeline detailed in the proposal. A no-cost extension was requested to conduct other relevant experiment- specifically regarding the characterization droplet ejection during energetic plasma flux impact. A specially designed trench module, which could accommodate trenches with different aspect ratios was fabricated and installed in the TELS setup and plasma gun experiments were performed. Droplet ejectionmore » was characterized using high speed image acquisition and also surface mounted probes were used to characterize the plasma. The Gantt chart below had been provided with the original proposal, indicating the tasks to be performed in the third year of funding. These tasks are listed above in the progress report outline, and their progress status is detailed below.« less

Development of a beverage benchtop prototype based on sweet potato peels: optimization of antioxidant activity by a mixture design.

PubMed

Anastácio, Ana; Carvalho, Isabel Saraiva de

2015-08-01

A beverage benchtop prototype related to oxidative stress protection was developed based on sweet potato peels phenolics. Formula components were sweet potato peel (Ipomoeas batatas L.) aqueous extract (SPPE), sweet potato leaves water extract (SPLE) and honey solution (HonS). According to linear squares regression (LSR) models, SPLE presented higher additive effect on total phenolic content (TPC), FRAP and DPPH than the other components. All antagonist interactions were not significant. The optimum formula obtained by artificial neural networks (ANN) analysis was 50.0% of SPPE, 21.5% of SPLE and 28.5% of HonS. Predicted responses of TPC, FRAP, DPPH and soluble solids were 309 mg GAE/L, 476 mg TE/L, 1098 mg TE/L and 12.3 °Brix, respectively. Optimization with LSR models was similar to ANN. Beverage prototype results positioned next to commercial vegetable and fruit beverages, thus it has an interesting potential to the market of health and wellness.

Mobile Technology in E-Learning for Undergraduate Medical Education on Emergent Otorhinolaryngology–Head and Neck Surgery Disorders: Pilot Randomized Controlled Trial

PubMed Central

Lee, Li-Ang; Wang, Shu-Ling; Chao, Yi-Ping; Tsai, Ming-Shao; Hsin, Li-Jen; Kang, Chung-Jan; Fu, Chia-Hsiang; Chao, Wei-Chieh; Huang, Chung-Guei; Li, Hsueh-Yu

2018-01-01

Background The use of mobile technology in e-learning (M-TEL) can add new levels of experience and significantly increase the attractiveness of e-learning in medical education. Whether an innovative interactive e-learning multimedia (IM) module or a conventional PowerPoint show (PPS) module using M-TEL to teach emergent otorhinolaryngology–head and neck surgery (ORL-HNS) disorders is feasible and efficient in undergraduate medical students is unknown. Objective The aim of this study was to compare the impact of a novel IM module with a conventional PPS module using M-TEL for emergent ORL-HNS disorders with regard to learning outcomes, satisfaction, and learning experience. Methods This pilot study was conducted at an academic teaching hospital and included 24 undergraduate medical students who were novices in ORL-HNS. The cognitive style was determined using the Group Embedded Figures Test. The participants were randomly allocated (1:1) to one of the two groups matched by age, sex, and cognitive style: the IM group and the PPS group. During the 100-min learning period, the participants were unblinded to use the IM or PPS courseware on a 7-inch tablet. Pretests and posttests using multiple-choice questions to evaluate knowledge and multimedia situational tests to evaluate competence were administered. Participants evaluated their satisfaction and learning experience by the AttrakDiff2 questionnaire, and provided feedback about the modules. Results Overall, the participants had significant gains in knowledge (median of percentage change 71, 95% CI 1-100, P<.001) and competence (median of percentage change 25, 95% CI 0-33, P=.007) after 100 min of learning. Although there was no significant difference in knowledge gain between the two groups (median of difference of percentage change 24, 95% CI −75 to 36; P=.55), competence gain was significantly lower in the IM group compared with the PPS group (median of difference of percentage change −41, 95% CI −67 to �

Interactive Two-Way mHealth Interventions for Improving Medication Adherence: An Evaluation Using The Behaviour Change Wheel Framework.

PubMed

Chiang, Nicole; Guo, Michael; Amico, K Rivet; Atkins, Lou; Lester, Richard T

2018-04-12

Medication adherence is an important but highly complex set of behaviors, which for life-threatening and infectious diseases such as HIV carry critical consequences for individual and public health. There is growing evidence that mobile phone text messaging interventions (mHealth) connecting providers with patients positively impact medication adherence, particularly two-way engagement platforms that require bidirectional communication versus one-way in which responses are not mandatory. However, mechanisms of action have not been well defined. The Behavior Change Wheel is a comprehensive framework for behavior change that includes an all-encompassing model of behavior known as Capability Opportunity Motivation-Behavior and is complemented by a taxonomy of behavior change techniques. Evaluating mHealth interventions for medication adherence using these tools could provide useful insights that may contribute to optimizing their integration into the healthcare system and successful scaling-up. This study aimed to help address the current knowledge gap regarding how two-way mHealth interventions for medication adherence may work by applying the Behavior Change Wheel to characterize WelTel: an interactive digital health outreach platform with robust evidence for improving adherence to antiretroviral therapy. To characterize how WelTel may promote medication adherence, we applied the Behavior Change Wheel to systematically (1) generate a behavioral diagnosis through mapping known antiretroviral therapy adherence barriers onto the Capability Opportunity Motivation-Behavior model of behavior, (2) specify the behavior change techniques that WelTel delivers, (3) link identified behavior change techniques to corresponding intervention functions of the Behavior Change Wheel, and (4) connect these behavior change techniques and intervention functions to respective Capability Opportunity Motivation-Behavior influences on behavior to determine potential mechanisms of action. Our

Mid-late Holocene climate and vegetation in northeastern part of the Altai Mountains recorded in Lake Teletskoye

NASA Astrophysics Data System (ADS)

Rudaya, Natalia; Nazarova, Larisa; Novenko, Elena; Babich, Valery; Kalugin, Ivan; Daryin, Andrei

2015-04-01

We report the first high-resolution (with intervals ca. 20-50 years) late-Holocene (4200 yr BP) pollen record from Lake Teletskoye, Altai Mountains, obtained from the underwater Ridge of Sofia Lepneva in 2006 (core Tel 2006). The study presents (i) the results of palynological analysis of Tel 2006; (ii) the results of spectral analysis of natural cycles based on the periodical fluctuation of taiga-biome curve; and (iii) quantitative reconstructions of the late-Holocene regional vegetation, woody coverage and climate in northern part of the Altai Mountains in order to define place of Northeast Altai on the map of the late-Holocene Central Asian environmental history. Late Holocene vegetation of the northeastern part of Altai recorded in Tel 2006 core is characterized by spread of dark-coniferous forest with structure similar to modern. Dominant trees, Siberian pine (Pinus sibirica) and Siberian fir (Abies sibirica), are the most ecological sensitive taxa between Siberian conifers (Shumilova, 1962), that as a whole suggests mild and humid climatic conditions during last 4200 years. However, changes of pollen taxa percentages and results of numerical analysis reveal pronounced fluctuation of climate and vegetation. Relatively cool and dry stage occurred prior to ca. 3500 cal yr BP. Open vegetation was widespread in the region with maximum deforestation and minimal July temperatures between 3800-3500 cal yr BP. Steppe-like communities with Artemisia, Chenopodiaceae and Cyperaceae could grow on the open sites around Lake Teletskoye. Reconstructed woody coverage is very low and varies between 29-35%. After ca. 3500 cal yr BP the area of dark-coniferous mountain taiga has significantly enlarged with maximums of woody coverages and taiga biome scores between ca. 2470-1040 cal yr BP. In the period of ~3500-2500 cal yr BP the averages July temperatures increased more than 1 0C. Climate became warmer and wetter. During last millennium (after 1040 cal yr BP) average July

Characterizing a Middle Bronze Palatial Wine Cellar from Tel Kabri, Israel

PubMed Central

Koh, Andrew J.; Yasur-Landau, Assaf; Cline, Eric H.

2014-01-01

Scholars have for generations recognized the importance of wine production, distribution, and consumption in relation to second millennium BC palatial complexes in the Mediterranean and Near East. However, direct archaeological evidence has rarely been offered, despite the prominence of ancient viticulture in administrative clay tablets, visual media, and various forms of documentation. Tartaric and syringic acids, along with evidence for resination, have been identified in ancient ceramics, but until now the archaeological contexts behind these sporadic discoveries had been uneven and vague, precluding definitive conclusions about the nature of ancient viticulture. The situation has now changed. During the 2013 excavation season of the Kabri Archaeological Project, a rare opportunity materialized when forty large storage vessels were found in situ in an enclosed room located to the west of the central courtyard within the Middle Bronze Age Canaanite palace. A comprehensive program of organic residue analysis has now revealed that all of the relatively uniform jars contain evidence for wine. Furthermore, the enclosed context inherent to a singular intact wine cellar presented an unprecedented opportunity for a scientifically intensive study, allowing for the detection of subtle differences in the ingredients or additives within similar wine jars of apparently the same vintage. Additives seem to have included honey, storax resin, terebinth resin, cedar oil, cyperus, juniper, and perhaps even mint, myrtle, or cinnamon, all or most of which are attested in the 18th century BC Mari texts from Mesopotamia and the 15th century BC Ebers Papyrus from Egypt. These additives suggest a sophisticated understanding of the botanical landscape and the pharmacopeic skills necessary to produce a complex beverage that balanced preservation, palatability, and psychoactivity. This new study has resulted in insights unachievable in the past, which contribute to a greater understanding not only of ancient viticulture but also of Canaanite palatial economy. PMID:25162228

Characterizing a Middle Bronze palatial wine cellar from Tel Kabri, Israel.

PubMed

Koh, Andrew J; Yasur-Landau, Assaf; Cline, Eric H

2014-01-01

Scholars have for generations recognized the importance of wine production, distribution, and consumption in relation to second millennium BC palatial complexes in the Mediterranean and Near East. However, direct archaeological evidence has rarely been offered, despite the prominence of ancient viticulture in administrative clay tablets, visual media, and various forms of documentation. Tartaric and syringic acids, along with evidence for resination, have been identified in ancient ceramics, but until now the archaeological contexts behind these sporadic discoveries had been uneven and vague, precluding definitive conclusions about the nature of ancient viticulture. The situation has now changed. During the 2013 excavation season of the Kabri Archaeological Project, a rare opportunity materialized when forty large storage vessels were found in situ in an enclosed room located to the west of the central courtyard within the Middle Bronze Age Canaanite palace. A comprehensive program of organic residue analysis has now revealed that all of the relatively uniform jars contain evidence for wine. Furthermore, the enclosed context inherent to a singular intact wine cellar presented an unprecedented opportunity for a scientifically intensive study, allowing for the detection of subtle differences in the ingredients or additives within similar wine jars of apparently the same vintage. Additives seem to have included honey, storax resin, terebinth resin, cedar oil, cyperus, juniper, and perhaps even mint, myrtle, or cinnamon, all or most of which are attested in the 18th century BC Mari texts from Mesopotamia and the 15th century BC Ebers Papyrus from Egypt. These additives suggest a sophisticated understanding of the botanical landscape and the pharmacopeic skills necessary to produce a complex beverage that balanced preservation, palatability, and psychoactivity. This new study has resulted in insights unachievable in the past, which contribute to a greater understanding not only of ancient viticulture but also of Canaanite palatial economy.

7 CFR 29.68 - Advance information.

Code of Federal Regulations, 2014 CFR

2014-01-01

... 7 Agriculture 2 2014-01-01 2014-01-01 false Advance information. 29.68 Section 29.68 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... part of the contents of such certificate may be tel- egraphed or telephoned to him as his expense...

7 CFR 29.68 - Advance information.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 2 2013-01-01 2013-01-01 false Advance information. 29.68 Section 29.68 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... part of the contents of such certificate may be tel- egraphed or telephoned to him as his expense...

7 CFR 29.68 - Advance information.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 2 2012-01-01 2012-01-01 false Advance information. 29.68 Section 29.68 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... part of the contents of such certificate may be tel- egraphed or telephoned to him as his expense...

7 CFR 29.68 - Advance information.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 2 2011-01-01 2011-01-01 false Advance information. 29.68 Section 29.68 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... part of the contents of such certificate may be tel- egraphed or telephoned to him as his expense...

31 CFR Appendix A to Part 560 - Persons Determined To Be the Government of Iran, as Defined in § 560.304 of This Part

Code of Federal Regulations, 2011 CFR

2011-07-01

... through the following page on OFAC's Web site: http://www.treasury.gov/sdn. Additional information.... This document and additional information concerning OFAC are available from OFAC's Web site: http://www... via facsimile through a 24-hour fax-on-demand service, tel.: 202/622-0077. Please consult OFAC's Web...

Violation of human rights and the nursing profession.

PubMed

Tornbjerg, A; Jacobsen, L

1985-01-01

In Denmark, at Copenhagen's University Hospital there is an International Rehabilitation and Research Centre for Torture Victims where work began early in the 1980's. Since May, 1984 treatment has taken place and two nurses, working with Centre, described the situation at the ICN Congress in Tel Aviv.

Academic Workload: The Silent Barrier to the Implementation of Technology-Enhanced Learning Strategies in Higher Education

ERIC Educational Resources Information Center

Gregory, Mary Sarah-Jane; Lodge, Jason Michael

2015-01-01

The effect of technology-enhanced learning (TEL) strategies in higher education has arguably been transformative despite the not-insignificant barriers existing in this context. Throughout the discourse very little attention has been paid to those primarily responsible for this implementation--academic teaching staff. This paper aims to highlight…

Flexible Pedagogies: Technology-Enhanced Learning. Flexible Pedagogies: Preparing for the Future Series

ERIC Educational Resources Information Center

Gordon, Neil

2014-01-01

This publication is part of our five-strand research project "Flexible Pedagogies: preparing for the future". It focuses on a better understanding of technology-enhanced learning (TEL) and: (1) identifies key international drivers in the move towards technology-enhanced learning; (2) highlights some of the challenges and opportunities…

Making Mitosis Visible

ERIC Educational Resources Information Center

Williams, Michelle; Linn, Marcia C.; Hollowell, Gail P.

2008-01-01

The Technology-Enhanced Learning in Science (TELS) center, a National Science Foundation-funded Center for Learning and Teaching, offers research-tested science modules for students in grades 6-12 (Linn et al. 2006). These free, online modules engage students in scientific inquiry through collaborative activities that include online…

Dealing with a Nuclear Iran: Applying Historical Lessons in Deterrence

DTIC Science & Technology

2012-02-15

is not copyrighted, but is the property of the United States government. Biography Colonel Mark Doria is a U.S. Air Force fighter pilot...contaminated with radiation, including two of the most significant. Located in Jerusalem , just 25 miles from Tel Aviv, they are the Dome of the Rock

Context-Aware Recommender Systems for Learning: A Survey and Future Challenges

ERIC Educational Resources Information Center

Verbert, K.; Manouselis, N.; Ochoa, X.; Wolpers, M.; Drachsler, H.; Bosnic, I.; Duval, E.

2012-01-01

Recommender systems have been researched extensively by the Technology Enhanced Learning (TEL) community during the last decade. By identifying suitable resources from a potentially overwhelming variety of choices, such systems offer a promising approach to facilitate both learning and teaching tasks. As learning is taking place in extremely…

Facilitating Teachers' Reuse of Mobile Assisted Language Learning Resources Using Educational Metadata

ERIC Educational Resources Information Center

Zervas, Panagiotis; Sampson, Demetrios G.

2014-01-01

Mobile assisted language learning (MALL) and open access repositories for language learning resources are both topics that have attracted the interest of researchers and practitioners in technology enhanced learning (TeL). Yet, there is limited experimental evidence about possible factors that can influence and potentially enhance reuse of MALL…

76 FR 40903 - Grand River Dam Authority; Notice of Application for Amendment of License and Soliciting Comments...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-12

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 2524-019] Grand River Dam.... Date Filed: January 21, 2011. d. Applicant: Grand River Dam Authority. e. Name of Project: Salina... Zumwalt-Smith, General Counsel, Grand River Dam Authority, P.O. Box 409, Vinita, OK 73401-0409. Tel: (918...

Employing the TPACK Framework for Researcher-Teacher Co-Design of a Mobile-Assisted Seamless Language Learning Environment

ERIC Educational Resources Information Center

Wong, Lung-Hsiang; Chai, Ching Sing; Zhang, Xujuan; King, Ronnel B.

2015-01-01

Integrating technologies into teaching and learning poses a significant challenge for many teachers who lack socio-techno-pedagogical know-how and time to design interventions. A possible solution is to design sound technology-enhanced learning (TEL) environments with relevant content and pedagogical tools to reduce teachers' design efforts.…

78 FR 31631 - Designation of Three (3) Individuals Pursuant to Executive Order 13573 of May 18, 2011, “Blocking...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-05-24

... Pursuant to Executive Order 13573 of May 18, 2011, ``Blocking Property of Senior Officials of the...) individuals whose property and interests in property are blocked pursuant to Executive Order 13573 of May 18..., Tel.: 202/622-0077. Background On May 18, 2011, the President issued Executive Order 13573, ``Blocking...

Charting the Development of Technology-Enhanced Learning Developments across the UK Higher Education Sector: A Longitudinal Perspective (2001-2012)

ERIC Educational Resources Information Center

Walker, Richard; Voce, Julie; Jenkins, Martin

2016-01-01

This article reviews key findings from six surveys of technology-enhanced learning (TEL) across the UK higher education (HE) sector, conducted by Universities and Colleges Information Systems Association in association with Jisc. Updating the findings presented by Jenkins, Browne, Walker, and Hewitt [2010. The development of technology enhanced…

Online Learning and Performance Support in Organizational Environments Using Performance Support Platforms

ERIC Educational Resources Information Center

Gal, Eran; Nachmias, Rafi

2011-01-01

An electronic performance support system (EPSS) is a method that integrates learning and task performance into one single action by providing information and guidance during performance. Wide-range EPSS effectiveness research has been conducted by Tel Aviv University in tandem with a large telecommunications firm implementing EPSS solutions. The…

75 FR 3488 - Acadia National Park; Bar Harbor, ME; Acadia National Park Advisory Commission; Notice of Meeting

Federal Register 2010, 2011, 2012, 2013, 2014

2010-01-21

... DEPARTMENT OF THE INTERIOR National Park Service Acadia National Park; Bar Harbor, ME; Acadia National Park Advisory Commission; Notice of Meeting Notice is hereby given in accordance with the Federal..., Acadia National Park, P.O. Box 177, Bar Harbor, Maine 04609, tel: (207) 288-3338. Dated: January 7, 2010...

Effects of captopril, telmisartan and bardoxolone methyl (CDDO-Me) in ischemia-reperfusion-induced acute kidney injury in rats: an experimental comparative study.

PubMed

Kocak, Cengiz; Kocak, Fatma Emel; Akcilar, Raziye; Bayat, Zeynep; Aras, Bekir; Metineren, Mehmet Huseyin; Yucel, Mehmet; Simsek, Hasan

2016-02-01

Renal ischemia-reperfusion (IR) injury is one of the most common causes of acute kidney injury. This study investigated the effects of captopril (CAP), telmisartan (TEL) and bardoxolone methyl (BM) in animals with renal IR injury. Adult male Wistar-Albino rats were divided into six groups: control, vehicle, IR, IR with CAP, IR with TEL and IR with BM. Before IR was induced, drugs were administered by oral gavage. After a 60-min ischemia and a 120-min reperfusion period, bilateral nephrectomies were performed. Serum urea, creatinine, neutrophil gelatinase-associated lipocalin (NGAL) levels, tissue total oxidant status (TOS), total antioxidant status (TAS), total thiol (TT), asymmetric dimethylarginine (ADMA) levels, superoxide dismutase (SOD) activity and glutathione peroxidase (GSH-Px) activity were measured. Tissue mRNA expression levels of peroxisome proliferator-activated receptor-ɣ (PPAR-ɣ), nuclear factor erythroid 2-related factor 2 (Nrf2) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) were analyzed. In addition, renal tissues were evaluated histopathologically and immunohistochemically. All tested drugs reduced renal damage, apoptosis, urea, creatinine, NGAL, TOS, nitric oxide (NO) and ADMA levels, NF-κB, inducible nitric oxide synthase (iNOS) and endothelin-1 (ET-1) expressions (P < 0.001). All tested drugs increased SOD activity, GSH-Px activity, TAS levels, TT levels, endothelial nitric oxide synthase (eNOS) expression, dimethylarginine dimethylaminohydrolases (DDAHs) expression, Nrf2 expression and PPAR-ɣ expression (P < 0.001, P < 0.003). These results suggest that CAP, TEL and BM pretreatment could reduce renal IR injury via anti-inflammatory, antioxidant and anti-apoptotic effects. © 2016 John Wiley & Sons Australia, Ltd.

Investigation of physicochemical factors affecting the stability of a pH-modulated solid dispersion and a tablet during storage.

PubMed

Tran, Phuong Ha-Lien; Tran, Thao Truong-Dinh; Park, Jun-Bom; Min, Dong Hun; Choi, Han-Gon; Han, Hyo-Kyung; Rhee, Yun-Seok; Lee, Beom-Jin

2011-07-29

The stability of solid dispersions (SD) during storage is of concern. We prepared the pH-modulated SD (pSD) and compressed tablets consisting of polyethylene glycol (PEG) 6000 as a carrier, drug and MgO (alkalizer). Telmisartan (TEL), an ionizable poorly water-soluble drug, was chosen as a model drug. The changes in physicochemical factors such as the dissolution rate, drug crystallinity, microenvironmental pH (pH(M)) and intermolecular interactions of the pSD and the tablets were investigated over 3 months under different temperature and relative humidity (RH) conditions: refrigerator (5-8 °C), 25 °C/32% RH, 25 °C/55% RH, 25 °C/75% RH, 40°C/32% RH, 40 °C/55% RH, and 40 °C/75% RH. Differential scanning calorimetry (DSC) analysis of all samples revealed no distinct changes in the drug melting point. In contrast, powder X-ray diffraction (PXRD) diffractograms revealed that samples stored at 40 °C/75% RH for 1 month, 25 °C/75% RH for 3 months and 40 °C at all humidity conditions for 3 months showed gradual recrystallization of the drug. Fourier transform infrared (FTIR) spectra indicated a reduced intensity of intermolecular interactions between TEL and MgO in the pSD and tablet. The pH(M) also gradually decreased. These altered physicochemical factors under the stressed conditions resulted in decreased dissolution profiles in intestinal fluid (pH 6.8). In contrast, the dissolution rate in gastric fluid (pH 1.2) was almost unchanged because of the high intrinsic solubility of TEL at this pH. Copyright © 2011 Elsevier B.V. All rights reserved.

[Becoming parents. Factors related to the feeling of competence].

PubMed

Léonard, N; Paul, D

1996-01-01

In recent years, priority measures have been established within the health field in Québec for raising parents' self-esteem in regard to their role, and ensuring that their parenting skills improve. The study Perceptions de la relation conjugale, du fonctionnement familial et du sentiment de compétence parentale chez des pères et des mères d'un premier enfant âgé d'un an was conducted in keeping with these measures. Nathalie Léonard conducted the research as part of her studies toward a master's degree in nursing science; her thesis advisor was Denise Paul. One goal of her correlative descriptive study was to describe perceptions of the feeling of parental competence among couples with a first child one year of age. A survey of the literature enabled listing of the factors that influence the feeling of parental competence in three categories, according to whether it is linked to the parents, to the child or to their surroundings. Awareness of these factors enables nurses in hospital and community settings to provide more effective support to parents of a first child in their process of adapting to parenthood.

Researching Haptics in Higher Education: The Complexity of Developing Haptics Virtual Learning Systems and Evaluating Its Impact on Students' Learning

ERIC Educational Resources Information Center

San Diego, Jonathan P.; Cox, Margaret J.; Quinn, Barry F. A.; Newton, Jonathan Tim; Banerjee, Avijit; Woolford, Mark

2012-01-01

hapTEL, an interdisciplinary project funded by two UK research councils from 2007 to 2011, involves a large interdisciplinary team (with undergraduate and post-graduate student participants) which has been developing and evaluating a virtual learning system within an HE healthcare education setting, working on three overlapping strands. Strand 1…

77 FR 29750 - Fifteenth Meeting: RTCA Special Committee 214, Joint With EUROCAE WG-78, Standards for Air...

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-18

[email protected] , or Tel.: +31 43 366 1396. FOR FURTHER INFORMATION CONTACT: The RTCA Secretariat, 1150 18th....int no later than May 21, 2012 with the following security information: Last Name/ First name... cargo hangers-- first flight at between 06:00 and 06:15) SUPPLEMENTARY INFORMATION: Pursuant to section...

75 FR 51985 - Federal Advisory Committee; Advisory Council on Dependents' Education (ACDE)

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-24

..., Germany. DATES: The meetings will be held: 1. Friday, November 12, 2010, from 8 a.m. to 11 a.m. (Eastern... Time), in Riedstadt, Germany. ADDRESSES: The meetings will be held: 1. Arlington--4040 North Fairfax..., Germany 64560. FOR FURTHER INFORMATION CONTACT: Committee's Point of Contact: Ms. Leesa Rompre, tel. (703...

Serving the Needs of Various Groups of Stakeholders.

ERIC Educational Resources Information Center

Geva-May, Iris; Peretz, Hannah

1991-01-01

The extent to which evaluation results answer different stakeholders' needs was explored in the evaluation of a business English course at Van Leer Institute for the Development of Executive Assistants in Tel-Aviv (Israel), using diagnostic tests. Students (n=52), teachers, curriculum team, and administrators could use the evaluation results. (SLD)

Assessing the Crossdisciplinarity of Technology-Enhanced Learning with Science Overlay Maps and Diversity Measures

ERIC Educational Resources Information Center

Kalz, Marco; Specht, Marcus

2014-01-01

This paper deals with the assessment of the crossdisciplinarity of technology-enhanced learning (TEL). Based on a general discussion of the concept interdisciplinarity and a summary of the discussion in the field, two empirical methods from scientometrics are introduced and applied. Science overlay maps and the Rao-Stirling diversity index are…

Some Aspects of Computer-Supported Teaching When Teaching Bachelors

ERIC Educational Resources Information Center

Svetsky, Stefan; Moravcik, Oliver; Schreiber, Peter; Stefankova, Jana

2013-01-01

The state of the art of TEL (technology-enhanced learning) is characterised by a technological-driven approach. Learning management systems or learning courses for management systems are mentioned as frequently used basic tools for this purpose. However, these Internet technologies are not suitable for the personalized support of teachers on…

Dimensions of Personalisation in Technology-Enhanced Learning: A Framework and Implications for Design

ERIC Educational Resources Information Center

FitzGerald, Elizabeth; Kucirkova, Natalia; Jones, Ann; Cross, Simon; Ferguson, Rebecca; Herodotou, Christothea; Hillaire, Garron; Scanlon, Eileen

2018-01-01

Personalisation of learning is a recurring trend in our society, referred to in government speeches, popular media, conference and research papers and technological innovations. This latter aspect--of using personalisation in technology-enhanced learning (TEL)--has promised much but has not always lived up to the claims made. Personalisation is…

Proceedings of the 30th Annual Precise Time and Time Interval (PTTI) Systems and Applications Meeting

DTIC Science & Technology

1999-01-01

roa.es C. Tomis RedIRIS, Centro Comunicaciones CSIC RedIRIS Serrano 142, 28006 Madrid, Spain tel + 34-91-585-5150 fax +34-91-564-7421 e-mail...I&D) and managed by the Centro de Comunicaciones CSIC RedIRIS, which depends on the Scientific Research Council (Consejo Superior de Investigaciones

Investigation of the Correlation Between Neurocognitive Function with Advanced Magnetic Resonance Imaging (MRI), Electroencephalography (EEG) in Patients with Traumatic Brain Injury Exposure: Neurocognitive function and advanced MRI and EEG

DTIC Science & Technology

2011-01-01

rotation soudaine , à la tête engendré par des forces externes. Des symptômes persistants tels que maux de tête, troubles du sommeil, problèmes...neuropsychological findings in veterans with traumatic brain injury and/or post traumatic stress disorder. Military Medicine. Brenner, L.A. et al . (2010

The Effectiveness of Low-Cost Tele-Lecturing.

ERIC Educational Resources Information Center

Muta, Hiromitsu; Kikuta, Reiko; Hamano, Takashi; Maesako, Takanori

1997-01-01

Compares distance education using PictureTel, a compressed-digital-video system via telephone lines (audio and visual interactive communication) in terms of its costs and effectiveness with traditional in-class education. Costing less than half the traditional approach, the study suggested distance education would be economical if used frequently.…

2014 Abridged Technology and Engineering Literacy Framework for the 2014 National Assessment of Educational Progress

ERIC Educational Resources Information Center

National Assessment Governing Board, 2014

2014-01-01

Due to the growing importance of technology and engineering in the educational landscape, and to support America's ability to contribute to and compete in a global economy, the National Assessment Governing Board (NAGB) initiated development of the first NAEP Technology and Engineering Literacy (TEL) Assessment. Relating to national efforts in…

Conduct of the Persian Gulf War: Final Report to Congress. Chapters 1 through 8. Sanitized Version

DTIC Science & Technology

1992-04-01

missiles, missiles launched from the complexes could reach the Israeli cities of Tel Aviv, Haifa, and the nuclear facility at Dimona in the Negev ...Special Warfare:264,375,407 near-real time:31,220,235,247 near-shore: 298-299 Negev :16 network: 14-15,19,33,114,118-119,139

76 FR 56471 - Meeting of the John H. Chafee Blackstone River Valley National Heritage Corridor Commission

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-13

... the meeting in person in The Museum of Work and Culture, Market Square, 42 South Main Street... Commission meeting will be conducted at the Museum of Work and Culture, Market Square, 42 South Main Street... National Heritage Corridor Commission, One Depot Square, Woonsocket, RI 02895. Tel.: (401) 762-0250. E-mail...

78 FR 9446 - Advance Nanotech, Inc., Advanced ID Corp., Aeon Holdings, Inc. (n/k/a BCM Energy Partners, Inc...

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-08

...., Aeon Holdings, Inc. (n/k/a BCM Energy Partners, Inc.), ANTS Software, Inc., Beauty Brands Group, Inc... Kourseware International, Inc., Ensign Services, Inc., and eTelCharge.com , Inc.; Order of Suspension of... ANTS Software, Inc. because it has not filed any periodic reports since the period ended March 31, 2011...

76 FR 55167 - Designation of Three Individuals Pursuant to Executive Order 13573 of May 18, 2011, “Blocking...

Federal Register 2010, 2011, 2012, 2013, 2014

2011-09-06

... Pursuant to Executive Order 13573 of May 18, 2011, ``Blocking Property of Senior Officials of the... individuals whose property and interests in property are blocked pursuant to Executive Order 13573 of May 18...-hour fax-on-demand service, Tel.: 202/622-0077. Background On May 18, 2011, the President issued...

Prose and Cons: Theatrical Encounters with Students and Prisoners in Ma'asiyahu, Israel

ERIC Educational Resources Information Center

Kuftinec, Sonja; Alon, Chen

2007-01-01

This article details how a unique educational project conducted through Tel Aviv University's Community Theatre program tackled the complex dynamics of the prison-political system over nine months in 2005-2006. The program focused on theatrical facilitations between mainly female students and male prisoners - two more or less homogeneous groups…

Evaluating and Measuring How New Technologies and Ubiquitous Connectivity Affect University Students' Psychosocial Wellbeing

ERIC Educational Resources Information Center

Taylor, J.; Salvagno, M.; Morris, R.; Hutchings, M.; Bobeva, M.

2018-01-01

Where universities focus on the benefits of technology-enhanced learning (TEL), they tend to underestimate the impact on learners' experiences and wellbeing. The goal of the research reported in this article was to investigate how new technologies and ubiquitous connectivity affect students' day-to-day life, learning habits and consequent…

Integration of Technology Enhanced Learning within Business Organizations: Which Strategy to Choose?

ERIC Educational Resources Information Center

Kaminskiene, Lina; Rutkiene, Aušra; Trepule, Elena

2015-01-01

The article discusses a responsible and a responsive strategic organizational approach for a smooth integration of technology enhanced learning (TEL). A response to external and internal contingencies and an involvement of different stakeholders into the development and implementation of the so-called eLearning strategies is one of the approaches…

The Test of Economic Literacy and an Evaluation of the DEEP System.

ERIC Educational Resources Information Center

Soper, John C.; Brenneke, Judith Staley

1981-01-01

Compares traditional and recent tests used to measure economic literacy at the secondary school level. Suggests that the new Test of Economic Literacy provides a badly needed replacement for previous tests such as the TEL and relates how the Developmental Economic Education Program (DEEP) affects academic achievement in economics. (Author/DB)

Critical Perspectives of Technology-Enhanced Learning in Relation to Specialist Communication Design Studio Education within the UK and Australia

ERIC Educational Resources Information Center

Marshalsey, Lorraine; Sclater, Madeleine

2018-01-01

This paper investigates the widespread integration of technology-enhanced learning (TEL) within specialist Communication Design studio education in the UK and Australia. The impetus for this paper has grown from the challenges facing day-to-day design studio education and the recognition that the use of technology in higher education today has…

Colouring the Gaps in Learning Design: Aesthetics and the Visual in Learning

ERIC Educational Resources Information Center

Carroll, Fiona; Kop, Rita

2016-01-01

The visual is a dominant mode of information retrieval and understanding however, the focus on the visual dimension of Technology Enhanced Learning (TEL) is still quite weak in relation to its predominant focus on usability. To accommodate the future needs of the visual learner, designers of e-learning environments should advance the current…

Principals' Sense of Uncertainty and Organizational Learning Mechanisms

ERIC Educational Resources Information Center

Schechter, Chen; Asher, Neomi

2012-01-01

Purpose: The purpose of the present study is to examine the effect of principals' sense of uncertainty on organizational learning mechanisms (OLMs) in schools. Design/methodology/approach: Data were collected from 130 school principals (90 women and 40 men) from both Tel-Aviv and Central districts in Israel. After computing the correlation between…

Sustaining Learning Design and Pedagogical Planning in CSCL

ERIC Educational Resources Information Center

Pozzi, Francesca; Francesca, Donatella

2013-01-01

This paper tackles the issue of learning design and pedagogical planning in the context of computer-supported collaborative learning (CSCL). In this sector, we witness the same variety of approaches and tools that we find in the technology-enhanced learning (TEL) research field. In particular, in the CSCL context, notions such as…

Teachers' Perspectives on Digital Tools for Pedagogic Planning and Design

ERIC Educational Resources Information Center

Masterman, Elizabeth; Manton, Marion

2011-01-01

The authors introduce the concept of design support tools and situate them in the pedagogic context of professional development for technology-enhanced learning (TEL) and the research field of learning design. Through focusing on the development and evaluation of one such tool, Phoebe, they discuss their value to lecturers in post-compulsory…

Defense.gov Special Report: Travels with Gates - March 2011

Science.gov Websites

in the U.S.-Israel relationship and the implications of dramatic Middle East political shifts were Barak. Story Gates: U.S.-Israeli Defense Relationship Never Stronger TEL AVIV, Israel, March 24, 2011 - Noting that their military relationship has never been stronger, Defense Secretary Robert M. Gates said

A Critical Evaluation of the Contribution of Trust to Effective Technology Enhanced Learning in the Workplace: A Literature Review

ERIC Educational Resources Information Center

Short, Heather

2014-01-01

This paper offers a critical review of the literature that explores the building and development of trust in workplace learning, particularly in a virtual context and its implications for Technology Enhanced Learning (TEL) in business. Trust is increasingly recognised as important in both business and education, and is the focus of increasing…

Cicatricial Pemphigoid

MedlinePlus

... can usually prevent blindness. © 2005 American Academy of Oral and Maxillofacial Pathology 214 North Hale Street Wheaton, IL 60187 Tel.: 630-510-4552 Fax: 630-510-4501 Toll Free: 888-552-2667 Email: ... mucous membranes, that is, the moist linings of the mouth, the eyes, the nose and throat, and the ...

A Study of the Role of a Technology-Enhanced Learning Implementation Group in Mediating an Institutional VLE Minimum Standards Policy

ERIC Educational Resources Information Center

Varga-Atkins, Tünde

2016-01-01

Recent years have seen a focus on responding to student expectations in higher education. As a result, a number of technology-enhanced learning (TEL) policies have stipulated a requirement for a minimum virtual learning environment (VLE) standard to provide a consistent student experience. This paper offers insight into an under-researched area of…

Higher Education Expenditures and State Balanced Budget Requirements: Is There a Relationship?

ERIC Educational Resources Information Center

Serna, Gabriel R.; Harris, Gretchen

2014-01-01

While recent research has shown that restrictive state fiscal policies, such as tax and expenditure limitations (TELs), matter for state spending to public higher education, no study has examined the impacts that other restrictive state fiscal policies might have on expenditures to this same sector. In this analysis we examine the relationship…

Online Persistence in Higher Education Web-Supported Courses

ERIC Educational Resources Information Center

Hershkovitz, Arnon; Nachmias, Rafi

2011-01-01

This research consists of an empirical study of online persistence in Web-supported courses in higher education, using Data Mining techniques. Log files of 58 Moodle websites accompanying Tel Aviv University courses were drawn, recording the activity of 1189 students in 1897 course enrollments during the academic year 2008/9, and were analyzed…

The Interaction Between Tax and Expenditure Limitations, Supermajority Requirements, and School Finance Litigation

ERIC Educational Resources Information Center

Jordan, Teresa S.; Jordan, K. Forbis; Crawford, James

2005-01-01

This article focuses on the change in selected state-level school finance variables from 1970 to 2000, with particular attention to the changes in these variables and school finance litigation decisions in states with and without state-level tax and expenditure limitations (TELs) or supermajority requirements (SMRs). The magnitude of the decrease…

75 FR 74704 - South Carolina Electric and Gas Company; Notice of Application for Amendment of License and...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-12-01

... Company, Mail Code A221, 220 Operation Way, Cayce, South Carolina 29033-3701. Tel: (803) 217-9162. i. FERC... withdrawal from, and discharge to, the Project's Monticello and Parr reservoirs to serve the construction and operation needs of two new nuclear generating plants at the V.C. Summer Nuclear Station. To facilitate this...

Schooling as a Knowledge System: Lessons from Cramim Experimental School

ERIC Educational Resources Information Center

Chen, David

2010-01-01

This article describes an experiment utilizing a research and development strategy to design and implement an innovative school for the future. The development of Cramim Elementary School was a joint effort of researchers from Tel-Aviv University and the staff of the school. The design stage involved constructing a new theoretical framework that…

Education toward a More Economic Life Style.

ERIC Educational Resources Information Center

Paynton, Naomi

1979-01-01

A community-based project was carried out in two low-income, high density areas in Tel Aviv, Israel, to help mothers of large families gain more from the existing family budget. Areas covered included clothing, nutrition, household maintenance, and savings and insurance. Behavioral changes were greatest in the area of clothing. (Author/JH)

Changing against the Grain: Academy for Peace in a Reality of Conflict

ERIC Educational Resources Information Center

Hager, Tamar; Saba, Tuffaha

2009-01-01

This article recounts an attempt by administration and faculty to create a multinational and multicultural vision for Tel Hai Academic College in the Galilee in Israel. This uncommon initiative in the Israeli academia intends to transform the campus into a unique academic institution allowing equality and visibility for all cultural and national…

ICT Competence-Based Learning Object Recommendations for Teachers

ERIC Educational Resources Information Center

Sergis, Stylianos; Zervas, Panagiotis; Sampson, Demetrios G.

2014-01-01

Recommender Systems (RS) have been applied in the Technology enhanced Learning (TeL) field for facilitating, among others, Learning Object (LO) selection and retrieval. Most of the existing approaches, however, aim at accommodating the needs of learners and teacher-oriented RS are still an under-investigated field. Moreover, the systems that focus…

Association between Terror Attacks and Suicide Attempts

ERIC Educational Resources Information Center

Weizman, Tal; Yagil, Yaron; Schreiber, Shaul

2009-01-01

Based on Durkheim's "Control theory," we explored the association between frequency of terror attacks in Israel and the frequency of suicide attempts admitted to the Emergency Room of a major general hospital in Tel-Aviv (1999-2004). Analysis of the six-year study period as a whole revealed no significant correlation between the…

Reflections of Changes in Higher Education in Israel: The Case of Social Work Departments

ERIC Educational Resources Information Center

Davidovich, Nitza; Sharlin, Shlomo

2008-01-01

This study focuses on the profiles of students of social work and examines whether different profiles of students can be identified in various social work programs in Israel's institutions of higher education (Hebrew University of Jerusalem, Haifa University, Tel Aviv University and the College of Judea and Samaria). The article discusses the…

What Is High School Economics? Factors Contributing to Student Achievement and Attitudes.

ERIC Educational Resources Information Center

Walstad, William B.; Soper, John C.

1989-01-01

Presents study which extends the analysis of economic understanding and attitudes of high school students using a national data set of the Test of Economic Literacy (TEL). Using matched pre- and posttest scores, the study investigated factors that explained level of posttest economic achievement or attitudes and analyzed reasons for gains in…

Qvo Vadis Magister Artium? Policy Implications of Executive Master's Programmes in an Israeli Research University

ERIC Educational Resources Information Center

Yogev, Abraham

2010-01-01

During recent decades master's studies have mainly become professional, but in some countries, like Israel, they still are a stepping stone toward doctorate studies. Changes in that respect may however occur due to recent university marketization processes. Using Tel Aviv University as a case study, we focus on the executive master's programmes…

a Passage to the Universe

NASA Astrophysics Data System (ADS)

1995-11-01

Brussel, Campus Ofenplein, Pleinlaan 2, B-1050 Brussels, Tel. 0032-2-6293469, Fax 0032-9-3623976, E-mail csterken@is1.vub.ac.be Denmark: Mr. B. F. Joergensen, Tycho Brahe Planetariet, Gl. Kongevej 10, DK-1610 Copenhagen V, Tel. 0045-33-144888, Fax 0045-33-142888, E-mail tycho@inet.uni-c.dk Finland: Mr. M. Hotakainen, Taehtitieteellinen Yhdistys Ursa, Laivanvarustajankatu 9C 54, FIN-00140 Helsinki, Tel. 00358-0-174048, Fax 00358-0-657728 France: Mr. B. Pellequer, Geospace d'Aniane, Boite Postale 22, F-34150 Aniane, Tel. 0033-6-7034949, Fax 0033-6-7752864 Germany: Dr. K.-H. Lotze, Friedrich-Schiller-Universitaet, Max-Wien-Platz 1, D-07743 Jena, Germany, Tel. +49-3641-635904/636654, Fax +49-3641-636728 Greece: Dr. D. Simopoulos, Eugenides Foundation, Astronomy Department, 387 Sygrou Avenue, Palaio Faliro, GR-175 64 Athens, Tel. 0030-1-941-1181, Fax 0030-1-941-7372 Ireland: Dr. I. Elliot, Dunsink Observatory (Dublin Institute for Advanced Studies), Castleknock, Dublin 15, Tel. 00353-1- 838-7911/7959, Fax 00353-1-8387090, E-mail ie@dunsink.dias.ie Italy: Dr. B. Monsignori Fossi, Osservatorio Astrofisico di Arcetri, Largo Enrico Fermi 5, I-50125 Florence, Tel. 0039-55-2752246, Fax 0039-55-220039, E-mail bmonsignori@arcetri.astro.it The Netherlands: Dr. M. Drummen, Stichting `De Koepel', Zonnenburg 2, NL-3512 NL Utrecht, Tel. 0031-30-311360, Fax 0031-30-342852, E-mail dekoepel@knoware.nl Spain: Dr. A. Sanchez/Dr. T. Fernandez, Planetario de Madrid, Parque Tierno Galvan, E-28045 Madrid, Tel. 0034-1-4673578, Fax 0034-1-4681154, E-mail tfc@vilspa.esa.es Sweden: Dr. K. Loden, Stockholms Observatorium, S-133 36 Saltsjoebaden, Tel. 0046-8-164454, Fax 0046-8-7174719, E-mail lodenk@astro.su.se United Kingdom: Dr. A. M. Cohen, c/o The Association for Astronomy Education, 9 Hurst Lane, Bollington, Macclesfield, Cheshire SK10 5LN, England Notes: [1] See ESO Press Releases 08/93 of 5 November 1993 and 17/94

First light of the VLT planet finder SPHERE. II. The physical properties and the architecture of the young systems PZ Telescopii and HD 1160 revisited

NASA Astrophysics Data System (ADS)

Maire, A.-L.; Bonnefoy, M.; Ginski, C.; Vigan, A.; Messina, S.; Mesa, D.; Galicher, R.; Gratton, R.; Desidera, S.; Kopytova, T. G.; Millward, M.; Thalmann, C.; Claudi, R. U.; Ehrenreich, D.; Zurlo, A.; Chauvin, G.; Antichi, J.; Baruffolo, A.; Bazzon, A.; Beuzit, J.-L.; Blanchard, P.; Boccaletti, A.; de Boer, J.; Carle, M.; Cascone, E.; Costille, A.; De Caprio, V.; Delboulbé, A.; Dohlen, K.; Dominik, C.; Feldt, M.; Fusco, T.; Girard, J. H.; Giro, E.; Gisler, D.; Gluck, L.; Gry, C.; Henning, T.; Hubin, N.; Hugot, E.; Jaquet, M.; Kasper, M.; Lagrange, A.-M.; Langlois, M.; Le Mignant, D.; Llored, M.; Madec, F.; Martinez, P.; Mawet, D.; Milli, J.; Möller-Nilsson, O.; Mouillet, D.; Moulin, T.; Moutou, C.; Origné, A.; Pavlov, A.; Petit, C.; Pragt, J.; Puget, P.; Ramos, J.; Rochat, S.; Roelfsema, R.; Salasnich, B.; Sauvage, J.-F.; Schmid, H. M.; Turatto, M.; Udry, S.; Vakili, F.; Wahhaj, Z.; Weber, L.; Wildi, F.

2016-03-01

Context. The young systemsPZ Tel and HD 1160, hosting known low-mass companions, were observed during the commissioning of the new planet finder of the Very Large Telescope (VLT) SPHERE with several imaging and spectroscopic modes. Aims: We aim to refine the physical properties and architecture of both systems. Methods: We use SPHERE commissioning data and dedicated Rapid Eye Mount (REM) observations, as well as literature and unpublished data from VLT/SINFONI, VLT/NaCo, Gemini/NICI, and Keck/NIRC2. Results: We derive new photometry and confirm the short-term (P = 0.94 d) photometric variability of the star PZ Tel A with values of 0.14 and 0.06 mag at optical and near-infrared wavelengths, respectively. We note from the comparison to literature data spanning 38 yr that the star also exhibits a long-term variability trend with a brightening of ~0.25 mag. The 0.63-3.8 μm spectral energy distribution of PZ Tel B (separation ~25 AU) allows us to revise its physical characteristics: spectral type M7 ± 1, Teff = 2700 ± 100 K, log(g) < 4.5 dex, luminosity log(L/L⊙) = -2.51 ± 0.10 dex, and mass 38-72 MJ from "hot-start" evolutionary models combining the ranges of the temperature and luminosity estimates. The 1-3.8 μm SED of HD 1160 B (~85 au) suggests a massive brown dwarf or a low-mass star with spectral type M6.0, Teff = 3000 ± 100 K, subsolar metallicity [M/H] = -0.5-0.0 dex, luminosity log(L/L⊙) = -2.81 ± 0.10 dex, and mass 39-166 MJ. The physical properties derived for HD 1160 C (~560 au) from KsL'-band photometry are consistent with the discovery study. The orbital study of PZ Tel B confirms its deceleration and the high eccentricity of its orbit (e > 0.66). For eccentricities below 0.9, the inclination, longitude of the ascending node, and time of periastron passage are well constrained. In particular, both star and companion inclinations are compatible with a system seen edge-on. Based on "hot-start" evolutionary models, we reject other brown dwarf

Mobile Technology in E-Learning for Undergraduate Medical Education on Emergent Otorhinolaryngology-Head and Neck Surgery Disorders: Pilot Randomized Controlled Trial.

PubMed

Lee, Li-Ang; Wang, Shu-Ling; Chao, Yi-Ping; Tsai, Ming-Shao; Hsin, Li-Jen; Kang, Chung-Jan; Fu, Chia-Hsiang; Chao, Wei-Chieh; Huang, Chung-Guei; Li, Hsueh-Yu; Chuang, Cheng-Keng

2018-03-08

The use of mobile technology in e-learning (M-TEL) can add new levels of experience and significantly increase the attractiveness of e-learning in medical education. Whether an innovative interactive e-learning multimedia (IM) module or a conventional PowerPoint show (PPS) module using M-TEL to teach emergent otorhinolaryngology-head and neck surgery (ORL-HNS) disorders is feasible and efficient in undergraduate medical students is unknown. The aim of this study was to compare the impact of a novel IM module with a conventional PPS module using M-TEL for emergent ORL-HNS disorders with regard to learning outcomes, satisfaction, and learning experience. This pilot study was conducted at an academic teaching hospital and included 24 undergraduate medical students who were novices in ORL-HNS. The cognitive style was determined using the Group Embedded Figures Test. The participants were randomly allocated (1:1) to one of the two groups matched by age, sex, and cognitive style: the IM group and the PPS group. During the 100-min learning period, the participants were unblinded to use the IM or PPS courseware on a 7-inch tablet. Pretests and posttests using multiple-choice questions to evaluate knowledge and multimedia situational tests to evaluate competence were administered. Participants evaluated their satisfaction and learning experience by the AttrakDiff2 questionnaire, and provided feedback about the modules. Overall, the participants had significant gains in knowledge (median of percentage change 71, 95% CI 1-100, P<.001) and competence (median of percentage change 25, 95% CI 0-33, P=.007) after 100 min of learning. Although there was no significant difference in knowledge gain between the two groups (median of difference of percentage change 24, 95% CI -75 to 36; P=.55), competence gain was significantly lower in the IM group compared with the PPS group (median of difference of percentage change -41, 95% CI -67 to -20; P=.008). However, the IM group had

... and more eclipses!

NASA Astrophysics Data System (ADS)

1999-01-01

To prepare students for the big day, the Association for Science Education has produced activity packs aimed at primary and secondary levels, including photocopiable pages accompanied by detailed notes for teachers. Safe viewing, recording and reporting, modelling and explaining, understanding solar physics, as well as using IT and the Internet are all covered, to enable both teachers and students to make the most of the 1999 eclipse experience. ASE Booksales at College Lane, Hatfield, Herts AL10 9AA (tel: 01707 283000, free fax: 0800 371856) should be contacted for further details. Also available early in 1999 will be three Investigation packs to stimulate a scientific approach to the 1999 event. The School of Science and Mathematics at Sheffield Hallam University has worked in collaboration with UK scientists active in the field to develop the materials, and there will be opportunities for users to work together across the UK and not just in the zone of totality. Thus a pool of results can be built up nationwide of what is happening on the day. One pack is aimed at primary children, the second at secondary students and the third at the general public, including families with young children. Further information can be obtained from Sheffield Hallam University (tel: 0114 225 4881). And finally...! The magic of solar eclipses can be observed from the comfort of your own armchair thanks to some of the stunning visual images available from UCLimages. A 1999 calendar with 12 photographs taken by Dr Francisco Diego, five posters (size 60 cm by 42 cm) and a widescreen video can all be ordered from `Solar eclipse', UCLimages, 48 Riding House Street, London W1P 7PL (tel: 0171 504 9375, fax: 0171 436 1738, e-mail: images@ucl.ac.uk).

Five Years of Research Into Technology-Enhanced Learning at the Faculty of Materials Science and Technology

NASA Astrophysics Data System (ADS)

Svetský, Štefan; Moravčík, Oliver; Rusková, Dagmar; Balog, Karol; Sakál, Peter; Tanuška, Pavol

2011-01-01

The article describes a five-year period of Technology Enhanced Learning (TEL) implementation at the Faculty of Materials Science and Technology (MTF) in Trnava. It is a part of the challenges put forward by the 7th Framework Programme (ICT research in FP7) focused on "how information and communication technologies can be used to support learning and teaching". The empirical research during the years 2006-2008 was focused on technology-driven support of teaching, i. e. the development of VLE (Virtual Learning Environment) and the development of database applications such as instruments developed simultaneously with the information support of the project, and tested and applied directly in the teaching of bachelor students. During this period, the MTF also participated in the administration of the FP7 KEPLER project proposal in the international consortium of 20 participants. In the following period of 2009-2010, the concept of educational activities automation systematically began to develop. Within this concept, the idea originated to develop a universal multi-purpose system BIKE based on the batch processing knowledge paradigm. This allowed to focus more on educational approach, i.e. TEL educational-driven and to finish the programming of the Internet application - network for feedback (communication between teachers and students). Thanks to this specialization, the results of applications in the teaching at MTF could gradually be presented at the international conferences focused on computer-enhanced engineering education. TEL was implemented at a detached workplace and four institutes involving more than 600 students-bachelors and teachers of technical subjects. Four study programmes were supported, including technical English language. Altogether, the results have been presented via 16 articles in five countries, including the EU level (IGIP-SEFI).

Neurocognitive profile in psychotic versus nonpsychotic individuals with 22q11.2 deletion syndrome.

PubMed

Weinberger, Ronnie; Yi, James; Calkins, Monica; Guri, Yael; McDonald-McGinn, Donna M; Emanuel, Beverly S; Zackai, Elaine H; Ruparel, Kosha; Carmel, Miri; Michaelovsky, Elena; Weizman, Abraham; Gur, Ruben C; Gur, Raquel E; Gothelf, Doron

2016-10-01

The 22q11.2 deletion syndrome (22q11DS) is associated with increased rates of psychotic disorders and cognitive deficits, but large scale studies are needed to elucidate their interaction. The objective of this two-center study was to identify the neurocognitive phenotype of individuals with 22q11DS and psychotic disorders. We hypothesized that psychotic 22q11DS individuals compared to nonpsychotic deleted individuals would have more severe neurocognitive deficits, especially in executive function and social cognition. These deficits would be present when compared to IQ- matched individuals with Williams Syndrome (WS). Three groups were ascertained from the Tel Aviv and Philadelphia centers: 22q11DS individuals with a psychotic disorder (n=31), nonpsychotic 22q11DS (n=86) and typically-developing controls (TD, n=828). In Tel Aviv a group of individuals with WS (n=18) matched in IQ to the 22q11DS psychotic group was also included. The Penn Computerized Neurocognitive Battery (CNB) was used to assess a wide-range of cognitive functions and all patients underwent structured psychiatric evaluations. 22q11DS individuals performed poorly on all CNB domains compared to TD. Participants with 22q11DS and psychosis, compared to nonpsychotic 22q11DS, had more severe deficits in global neurocognitive performance (GNP), executive function, social cognition and episodic memory domains. The primary deficits were also significant when comparing the Tel Aviv 22q11DS psychotic group to IQ-matched individuals with WS. In conclusion, 22q11DS individuals with a psychotic disorder have specific neurocognitive deficits that are reliably identified cross nationality using the CNB. These cognitive dysfunctions should be further studied as potential endophenotypes of psychosis in 22q11DS and as targets for intervention. Copyright © 2016 Elsevier B.V. and ECNP. All rights reserved.

Negative subthreshold psychotic symptoms distinguish 22q11.2 deletion syndrome from other neurodevelopmental disorders: A two-site study.

PubMed

Mekori-Domachevsky, Ehud; Guri, Yael; Yi, James; Weisman, Omri; Calkins, Monica E; Tang, Sunny X; Gross, Raz; McDonald-McGinn, Donna M; Emanuel, Beverly S; Zackai, Elaine H; Zalsman, Gil; Weizman, Abraham; Gur, Ruben C; Gur, Raquel E; Gothelf, Doron

2017-10-01

About one third of individuals with 22q11.2 deletion syndrome (22q11.2DS) develop schizophrenia. Notably, a full-blown psychotic disorder is usually preceded by subthreshold symptoms. Therefore, it is important to identify early signs of psychosis in this population, a task that is complicated by the intellectual disabilities typically seen in 22q11.2DS. We aimed to identify subthreshold psychotic symptoms that distinguish 22q11.2DS from other neurodevelopmental disorders. The study included two independent cohorts from Tel Aviv and Philadelphia. 22q11.2DS (N=171) and typically developing (TD; N=832) individuals were enrolled at both sites and further compared to two groups with intellectual disabilities: Williams syndrome (WS; N=21) in the Tel Aviv cohort and idiopathic developmental disabilities (IDD; N=129) in the Philadelphia cohort. Participants and their primary caregivers were interviewed with the Structured Interview for Prodromal Symptoms (SIPS) and psychopathologies were assessed using standardized tools; general cognitive abilities were assessed with the Computerized Neurocognitive Battery. Negative/disorganized subthreshold syndrome was significantly more common in the 22q11.2DS group than in the WS (OR=3.90, 95% CI=1.34-11.34) or IDD (OR=5.05, 95% CI=3.01-10.08) groups. The 22q11.2DS group had higher scores than the two intellectual disabilities groups on several SIPS negative items, including avolition and decreased expression of emotion. Overall, there were few significant correlations between level of cognitive deficits and severity of negative symptoms in 22q11.2DS and only in the Tel Aviv cohort. Our findings suggest that 22q11.2DS individuals at the age of risk for developing psychosis should be closely monitored for negative symptoms. Copyright © 2016 Elsevier B.V. All rights reserved.

Adaptive Optics Microperimetry and OCT Images Show Preserved Function and Recovery of Cone Visibility in Macular Telangiectasia Type 2 Retinal Lesions

PubMed Central

Wang, Qinyun; Tuten, William S.; Lujan, Brandon J.; Holland, Jennifer; Bernstein, Paul S.; Schwartz, Steven D.; Duncan, Jacque L.; Roorda, Austin

2015-01-01

Purpose. To evaluate visual function and disease progression in the retinal structural abnormalities of three patients from two unrelated families with macular telangiectasia (MacTel) type 2. Methods. Adaptive optics scanning laser ophthalmoscopy (AOSLO) and AOSLO microperimetry (AOMP) were used to evaluate the structure and function of macular cones in three eyes with MacTel type 2. Cone spacing was estimated using histogram analysis of intercone distances, and registered spectral-domain optical coherence tomography (SD-OCT) scans were used to evaluate retinal anatomy. AOMP was used to assess visual sensitivity in and around areas of apparent cone loss. Results. Although overall lesion surface area increased, some initially affected regions subsequently showed clear, contiguous, and normally spaced cone mosaics with recovered photoreceptor inner/outer segment (IS/OS) reflectivity (two of two eyes). The AOMP test sites fell within three categories: normal-appearing cones (N), dimly reflecting cones (D), and RPE cell mosaics (R). At N sites, AOMP threshold values (arbitrary units [au]) increased with increasing eccentricity (slope = 0.054 au/degree, r2 = 0.77). The N thresholds ranged from 0.04 to 0.27 au, D thresholds from 0.04 to 0.33 au, and R thresholds from 0.14 to 1.00 au. There was measurable visual sensitivity everywhere except areas without intact external limiting membrane (ELM) and with diffuse scattering in the IS/OS and posterior tips of the outer segments (PTOS) regions on OCT. Conclusions. Visual sensitivity and recovery of cone visibility in areas of apparent focal cone loss suggests that MacTel type 2 lesions with a preserved ELM may contain functioning cones with abnormal scattering and/or waveguiding characteristics. (ClinicalTrials.gov number, NCT00254605.) PMID:25587056

Stress-related responses after 3 years of exposure to terror in Israel: are ideological-religious factors associated with resilience?

PubMed

Kaplan, Zeev; Matar, Michael A; Kamin, Ram; Sadan, Tamar; Cohen, Hagit

2005-09-01

The inhabitants of 3 different types of population centers in Israel were assessed as to stress-related symptomatology during 2003 and 2004. These centers have been exposed to 2 distinct forms of violence-sporadic, large-scale terror attacks in the metropolitan areas in the heart of Israel and daily "war-zone" conditions in the settlements beyond the 1967 borders of Israel. A semistructured interview and questionnaire survey of a random sample of 314 inhabitants of a suburb of Tel-Aviv, a settlement in the West Bank (Kiryat-Arba), and the Gush-Katif settlement cluster in the Gaza Strip was performed. Symptoms of acute stress and chronic (posttraumatic) stress as well as symptoms of general psychopathology and distress were assessed. The inhabitants of Gush-Katif, in spite of firsthand daily exposure to violent attacks, reported the fewest and least severe symptoms of stress-related complaints, the least sense of personal threat, and the highest level of functioning of all 3 samples. The most severely symptomatic and functionally compromised were the inhabitants of the Tel-Aviv suburb, who were the least frequently and least directly affected by exposure to violent attacks. Because the Gush-Katif population is exclusively religious, the data were reassessed according to religiousness. The religious inhabitants of Kiryat-Arba had almost the same symptom profile as the Gush-Katif population, whereas secular inhabitants of Kiryat-Arba reported faring worse than did either population in the Tel-Aviv suburb. Deeply held belief systems affecting life-views may impart significant resilience to developing stress-related problems, even under extreme conditions. Religiousness combined with common ideological convictions and social cohesion was associated with substantial resilience as compared to a secular metropolitan urban population.

Performance of Different Diagnostic Criteria for Familial Mediterranean Fever in Children with Periodic Fevers: Results from a Multicenter International Registry.

PubMed

Demirkaya, Erkan; Saglam, Celal; Turker, Turker; Koné-Paut, Isabelle; Woo, Pat; Doglio, Matteo; Amaryan, Gayane; Frenkel, Joost; Uziel, Yosef; Insalaco, Antonella; Cantarini, Luca; Hofer, Michael; Boiu, Sorina; Duzova, Ali; Modesto, Consuelo; Bryant, Annette; Rigante, Donato; Papadopoulou-Alataki, Efimia; Guillaume-Czitrom, Severine; Kuemmerle-Deschner, Jasmine; Neven, Bénédicte; Lachmann, Helen; Martini, Alberto; Ruperto, Nicolino; Gattorno, Marco; Ozen, Seza

2016-01-01

Our aims were to validate the pediatric diagnostic criteria in a large international registry and to compare them with the performance of previous criteria for the diagnosis of familial Mediterranean fever (FMF). Pediatric patients with FMF from the Eurofever registry were used for the validation of the existing criteria. The other periodic fevers served as controls: mevalonate kinase deficiency (MKD), tumor necrosis factor receptor-associated periodic syndrome (TRAPS), cryopyrin-associated periodic syndrome (CAPS), aphthous stomatitis, pharyngitis, adenitis syndrome (PFAPA), and undefined periodic fever from the same registry. The performances of Tel Hashomer, Livneh, and the Yalcinkaya-Ozen criteria were assessed. The FMF group included 339 patients. The control group consisted of 377 patients (53 TRAPS, 45 MKD, 32 CAPS, 160 PFAPA, 87 undefined periodic fevers). Patients with FMF were correctly diagnosed using the Yalcinkaya-Ozen criteria with a sensitivity rate of 87.4% and a specificity rate of 40.7%. On the other hand, Tel Hashomer and Livneh criteria displayed a sensitivity of 45.0 and 77.3%, respectively. Both of the latter criteria displayed a better specificity than the Yalcinkaya-Ozen criteria: 97.2 and 41.1% for the Tel Hashomer and Livneh criteria, respectively. The overall accuracy for the Yalcinkaya-Ozen criteria was 65 and 69.6% (using 2 and 3 criteria), respectively. Ethnicity and residence had no effect on the performance of the Yalcinkaya-Ozen criteria. The Yalcinkaya-Ozen criteria yielded a better sensitivity than the other criteria in this international cohort of patients and thus can be used as a tool for FMF diagnosis in pediatric patients from either the European or eastern Mediterranean region. However, the specificity was lower than the previously suggested adult criteria.

Ethnic differences in the frequency of subtypes of childhood acute lymphoblastic leukemia: results of the Malaysia-Singapore Leukemia Study Group.

PubMed

Ariffin, Hany; Chen, Siew-Peng; Kwok, Cecilia S; Quah, Thuan-Chong; Lin, Hai-Peng; Yeoh, Allen E J

2007-01-01

Childhood acute lymphoblastic leukemia (ALL) is clinically heterogeneous with prognostically and biologically distinct subtypes. Although racial differences in frequency of different types of childhood ALL have been reported, many are confounded by selected or limited population samples. The Malaysia-Singapore (MA-SPORE) Leukemia Study Group provided a unique platform for the study of the frequency of major subgroups of childhood ALL in a large cohort of unselected multiethnic Asian children. Screening for the prognostically important chromosome abnormalities (TEL-AML1, BCR-ABL, E2A-PBX1, and MLL) using multiplex reverse-transcription polymerase chain reaction was performed on 299 consecutive patients with ALL at 3 study centers (236 de novo, 63 at relapse), with the ethnic composition predominantly Chinese (51.8%) and Malay (34.8%). Reverse-transcription polymerase chain reaction was successful in 278 (93%) of cases screened. The commonest fusion transcript was TEL-AML1 (19.1%) followed by BCR-ABL (7.8%), MLL rearrangements (4.2%), and E2A-PBX1 (3.1%). Chinese have a significantly lower frequency of TEL-AML1 (13.3% in de novo patients) compared with Malays (22.2%) and Indians (21.7%) (P=0.04). Malays have a lower frequency of T-ALL (6.2%) compared with the Chinese and Indians (9.8%). Both Malays (7.4%) and Chinese (5.0%) have significantly higher frequency of BCR-ABL compared with the Indian population (P<0.05) despite a similar median age at presentation. Our study suggests that there are indeed significant and important racial differences in the frequency of subtypes of childhood ALL. Comprehensive subgrouping of childhood ALL may reveal interesting population frequency differences of the various subtypes, their risk factors and hopefully, its etiology.

Cyber Situation Awareness through Instance-Based Learning: Modeling the Security Analyst in a Cyber-Attack Scenario

DTIC Science & Technology

2012-01-01

Chocolate Avenue Hershey PA 17033 Tel: 717-533-8845 Fax: 717-533-8661 E-mail: cust@igi-global.com Web site: http://www.igi-global.com Copyright © 2011...Lawrence Erlbaum Associates. Anderson, J. R., & Lebiere, C. (2003). The New- ell test for a theory of mind. The Behavioral and Brain Sciences, 26(5

Exploring Technology-Enhanced Learning Using Google Glass to Offer Students a Unique Instructor's Point of View Live Laboratory Demonstration

ERIC Educational Resources Information Center

Man, Fung Fun

2016-01-01

Technology-enhanced learning (TEL) is fast gaining momentum among educational institutions all over the world. The usual way in which laboratory instructional videos are filmed takes the third-person view. However, such videos are not as realistic and sensorial. With the advent of Google Glass and GoPro cameras, a more personal and effective way…

Academy-Community Partnerships: Challenges and Changes in Israeli Urban Regeneration Projects

ERIC Educational Resources Information Center

Tal, Rinat Botbol; Fenster, Tovi; Kulka, Tal

2015-01-01

Students worked with low-income Jaffa residents on a 3-year building renewal project as part of a multidisciplinary clinic operated through the collaboration of the Faculty of Law, the Department of Geography at the Faculty of Humanities, and the Faculty of Management at Tel-Aviv University. Alternative models in the legal and planning literature…

Technologies, Learning and Culture: Some Emerging Themes

ERIC Educational Resources Information Center

Lally, Vic; Sclater, Madeleine; Brown, Ken

2018-01-01

This paper reflects on some of the themes emerging from a consideration of recent research at the nexus of technologies, learning and culture. The authors comment on the expansive nature of the concept of learning spaces in papers featuring an investigation of technology enhanced learning (TEL) and communication design studios in the UK and…

European SEPG 󈨥 Event Planner

DTIC Science & Technology

1997-06-01

three children and a teleworking terminal. These, I together with a love for DIY, leave little time for anything else. Profile - Hans Sassenburg Hans...Service Line Leader Nymoellevej 91, DK-2800 Lyngby, Denmark Tel: +45 45 23 33 96 Fax: +45 45 87 44 38 Internet: chap@dk.ibm.com Internet for Year 2000

Technology Enhanced Learning: A Case Study of NPTEL

ERIC Educational Resources Information Center

Nitonde, Rohidas

2018-01-01

Technology Enhanced Learning (TEL) is a major 21st century trend in Higher Education. There are several government initiatives in India towards e-learning. National Programme on Technology Enhanced Learning (NPTEL) is one of the major initiatives. The present paper is an assessment of various aspects of this programme. It aims at evaluating the…

Intersatellite Link Design Issues

DTIC Science & Technology

1985-01-01

of Science degree by Richard S. Fuhrmann has been approved for the Tel ecommunications Program by Frank S. Barnes Sadel W.’MaleyK Date --- 45 N... means , the holier of a monopoly when it comes to satellites. In the early . 70"s, the low cost per circuit qenerated interest in Nil Fj domestic

77 FR 16542 - President's Advisory Commission on Educational Excellence for Hispanics

Federal Register 2010, 2011, 2012, 2013, 2014

2012-03-21

...: Tuesday, April 3, 2012. Time: 9 a.m.-5 p.m. Pacific Daylight Time. ADDRESSES: Loker Student Union Ballroom, California State University, Dominguez Hills, 1000 E. Victoria St., Carson, CA 90747, Tel: 310-243- 3303. FOR... use PDF, you must have Adobe Acrobat Reader, which is available free at this site. For questions about...

Using a Mixed Methods Research Design in a Study Investigating the "Heads of e-Learning" Perspective towards Technology Enhanced Learning

ERIC Educational Resources Information Center

Almpanis, Timos

2016-01-01

This paper outlines the research design, methodology and methods employed in research conducted in the context of Higher Education Institutions (HEIs) and focuses on the Heads of e-Learning (HeLs) perspective about Technology Enhanced Learning (TEL) by campus-based UK institutions. This paper aims to expand on the research design and the research…

75 FR 37803 - Consumer & Governmental Affairs Bureau Seeks Comment on a Petition for Expedited Clarification...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-06-30

... FEDERAL COMMUNICATIONS COMMISSION [CG Docket No. 02-278; DA 10-997] Consumer & Governmental... Notice DA 10-997, which seeks comment on Global Tel's petition. Pursuant to 47 CFR 1.415 and 1.419 of the... 1.1206(b). The full text of document DA 10-997 and any subsequently filed documents in this matter...

Learntime and Learning Place-Focused Forward-Oriented Design for Learning in Technology-Enhanced Classrooms

ERIC Educational Resources Information Center

Sun, Susan Y. H.

2016-01-01

This study reports on a teacher's ongoing design activities in a fully online language course when the class was in progress. The aims were, firstly, to provide first-hand experience and insight into a teacher's design work in a real-life, technology-enhanced learning (TEL) classroom; and secondly, to facilitate reflective analysis of the emerging…

Neutron Scattering Studies of Classical and Quantum Fluids in Porous Media

DOE Office of Scientific and Technical Information (OSTI.GOV)

Glyde, Henry R.

This is an annual and the final report on DE-FG02-03ER46038 (ER46680) following a no cost extension of DE-FG02-03ER46038 from February 16, 2016 to November 15, 2016. The report period is February 16, 2016 to November 15, 2016. The contract DE-FG02-03ER46038 (ER46680) was closed on November 15, 2016. The contract institution is the University of Delaware, address: Room 210, Hullihen %%@ Hall, University of Delaware, Newark, DE 19716. The Principal Investigator is Henry R. Glyde, Department of Physics and Astronomy, University of Delaware, Newark, DE 19716 (email: glyde@udel.edu). The Administrative Point of Contact is Dale S. Weiss Tel: 302 831 3634more » dsweiss@udel.edu. The DOE Program is the Office of Basic Energy %%@ Sciences, U.S. Department of Energy, Germantown Building, 1000 Independence Ave., SW Washington, DC 20585. The program manager is Dr. P. Thiyagarajan, Neutron Scattering SC-22.2/ Germantown Bldg., Tel: 301-903-9706, email: P. Thiyagarajan@Science.DOE.GOV.« less

REFLECTIONS ON PHYSICAL CHEMISTRY: Science and Scientists

NASA Astrophysics Data System (ADS)

Jortner, Joshua

2006-05-01

This is the story of a young person who grew up in Tel-Aviv during the period of the establishment of the State of Israel and was inspired to become a physical chemist by the cultural environment, by the excellent high-school education, and by having been trained by some outstanding scientists at the Hebrew University of Jerusalem and, subsequently, by the intellectual environment and high-quality scientific endeavor at the University of Chicago. Since serving as the first chairman of the Chemistry Department of the newly formed Tel-Aviv University he has been immersed in research, in the training of young scientists, and in intensive and extensive international scientific collaboration. Together with the members of his "scientific family" he has explored the phenomena of energy acquisition, storage and disposal and structure-dynamics-function relations in large molecules, condensed phase, clusters and biomolecules, and is looking forward to many future adventures in physical chemistry. "What to leave out and what to put in? That's the problem." Hugh Lofting, Doctor Dolittle's Zoo, 1925

Sleeping under the threat of the Scud: war-related environmental insomnia.

PubMed

Lavie, P; Carmeli, A; Mevorach, L; Liberman, N

1991-01-01

The influence of the Scud missile attacks during the Persian Gulf war on the sleep of the Israeli population is described. Our study group comprised a random sample of 200 people (mean age 41.13 +/- 15.32) who were contacted by telephone during the third week of the war and interviewed about their sleep. Overall, 28% of the entire sample complained about sleep: 10% complained about mid-sleep awakenings, 4.5% on difficulties falling asleep, and 13.5% about the combination of the two. People living in the Tel Aviv and Haifa areas complained significantly more than those in the rest of the country. Women complained significantly more than men, and people with lower education complained significantly more than people with higher education. Only 3% of the sample reported using sleeping pills. During the war actigraphic sleep recordings in 19 adults living in the Tel Aviv and Haifa areas did not reveal any measurable decrease in sleep quality in comparison with pre-war recordings. Possible explanations for the discrepancy between the subjective and objective assessments are discussed.

The effect of mechanical grinding on the formation, crystalline changes and dissolution behaviour of the inclusion complex of telmisartan and β-cyclodextrins.

PubMed

Borba, Paola Aline Amarante; Pinotti, Marihá; Andrade, George Ricardo Santana; da Costa, Nivan Bezerra; Olchanheski Junior, Luiz Renato; Fernandes, Daniel; de Campos, Carlos Eduardo Maduro; Stulzer, Hellen Karine

2015-11-20

Telmisartan (TEL) was entrapped into β-cyclodextrin aiming the improvement of its biopharmaceutical properties of low solubility. A solid state grinding process was used to prepare the molecular inclusion complex (MIC) for up to 30min. The inclusion ratio of drug and β-cyclodextrin was established as 1:2 and 1:3 (mol/mol) by phase solubility study and Job Plot. DSC, XRPD and FTIR confirmed the molecular interactions between TEL and β-cyclodextrin. Computer molecular modeling supports the presence of hydrogen bonds between guest and host and demonstrated the most probable complexes configuration. MIC_1:2_30 and MIC_1:3_30 enhanced the dissolution rate of the drug achieving a delivery rate comparable with the reference medicine available in the market (81% and 87% in 5min, for MIC_1:3_30 and Micardis(®), respectively). These formulations showed rapid and effective antihypertensive effect against angiotensin II in rats up to 180min, with statistically significant results against placebo and control in the first 30min after administration. Copyright © 2015 Elsevier Ltd. All rights reserved.

Le satellite Encelade source d'ions N+ dans la magnétosphère de Saturne

NASA Astrophysics Data System (ADS)

Bouhram, Mehdi; Berthelier, Jean-Jacques; Illiano, Jean-Marie; Smith, Howard T.; Sittler, Edward C.; Crary, Frank J.; Young, Dave T.

2005-12-01

xml:lang="fr">RésuméLe premier passage de la sonde Cassini dans l'environnement de Saturne, au dessus de l'anneau E, a mis en évidence l'existence d'un plasma composé d'un mélange d'ions issus des produits de l'eau (H+, O+, OH+, H2O+) avec une faible composante en ions N+ (3 %). A partir d'un modèle simple du transport des ions dans la magnétosphère, nous montrons que la source de ces ions N+ coïncide avec le satellite Encelade. Un tel résultat peut s'expliquer par la présence de composés volatiles tels que l'ammoniac NH3 sur ce satellite de glace, supposé encore actif géologiquement, ou par la présence d'ions N+ d'origine externe préalablement implantés sur sa surface. Pour citer cet article : M. Bouhram et al., C. R. Physique 6 (2005).

Development of a Combination Therapy for Prostate Cancer by Targeting Stat3 and HIF-1alpha

DTIC Science & Technology

2012-07-01

normoxia (N means: normoxia). 6    (32,33), a developed Stat3 inhibitor, to inhibits p-Stat3 in cancer cells ( PANC -1) and then after 3 hours adding...Fig. 8: Nude mice with pancreatic tumors ( PANC -1) treated by TEL03 in 19 days (down panels). Fig.9: (A) Plot of mean tumor volumes (mm3) versus

Fall proof: improving mobility and balance Elizabeth Best-Martini Fall proof: improving mobility and balance and Kim A Botenhagen-Di Genova Human Kinetics £24.50 0 73603 687 3 0736036873 Debra Rose Human Kinetics £38 0 73604 088 9 0736040889.

PubMed

2003-09-01

A structured balance and mobility-training programme specifically designed to reduce physical frailty and the rising incidence of falls among older people. This practical manual blends theory into practical applications and covers an introduction to the body systems, balance assessments and a discussion of contemporary motor learning principles. Tel: Customer Services 0113 255 5665. Email: hk@hkeurope.com.

Drawing Links within Dental Education

ERIC Educational Resources Information Center

Wright, J.

2017-01-01

This study examines results of a practical drawing task given to a cohort of first year dental surgery students at Kings College Dental Institute, London. It compares and relates their success in drilling and removing caries and pulp tissue from a virtual tooth using the hapTEL virtual learning system, with each individuals' drawing skills.…

29 CFR 779.352 - Requirements for exemption.

Code of Federal Regulations, 2010 CFR

2010-07-01

... POLICY OR INTERPRETATION NOT DIRECTLY RELATED TO REGULATIONS THE FAIR LABOR STANDARDS ACT AS APPLIED TO... exemption are: (a) The establishment in which the employee or proprietor works must qualify as an exempt... (See Western Union Tel. Co. v. McComb 165 F. 2d. 65 (CA-6), certiorari denied, 333 U.S. 362); and (d...

Measuring Learning Gain: Comparing Anatomy Drawing Screencasts and Paper-Based Resources

ERIC Educational Resources Information Center

Pickering, James D.

2017-01-01

The use of technology-enhanced learning (TEL) resources is now a common tool across a variety of healthcare programs. Despite this popular approach to curriculum delivery there remains a paucity in empirical evidence that quantifies the change in learning gain. The aim of the study was to measure the changes in learning gain observed with anatomy…

77 FR 6819 - Notice of Filing of Plats of Survey; Alaska

Federal Register 2010, 2011, 2012, 2013, 2014

2012-02-09

... No. 4615, Alaska, located within the Barrow Townsite, situated within Tps. 22 and 23 N., R. 18 W...: Bureau of Land Management, Alaska State Office; 222 W. 7th Ave., Stop 13; Anchorage, AK 99513-7599. FOR..., BLM-Alaska State Office; 222 W. 7th Ave., Stop 13; Anchorage, AK 99513-7599; Tel: 907-271-5481; fax...

A Visit to a Montessori Elementary Class in Israel

ERIC Educational Resources Information Center

Fernando, Chandra

2006-01-01

The author of this article describes her week observing a Montessori class in the Adam Vesviva School at Kibbutz Ga'ash, located on the outskirts of Tel Aviv. The headmaster of the school, Yariv Ya'ari, had previously been associated with Democratic Schools, an alternate to the public educational system, whose philosophy was established at Adam…

A Novel Anti-Beta2-Microglobulin Antibody Inhibition of Androgen Receptor Expression, Survival, and Progression in Prostate Cancer Cells

DTIC Science & Technology

2010-05-01

Uro -Oncology Research Pro- gram, Dept. of Medicine, Cedars-Sinai Medical Center, 8750 Beverly Blvd., Atrium 103, Los Angeles, CA 90048. Tel.: 310...ORGANIZATION: Cedars-Sinai Medical Center Los Angeles, California 90048 REPORT DATE: May...Cedars-Sinai Medical Center Los Angeles, California 90048 9. SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM

A Block Randomized Controlled Trial of a Brief Smoking Cessation Counselling and Advice through Short Message Service on Participants Who Joined the Quit to Win Contest in Hong Kong

ERIC Educational Resources Information Center

Chan, Sophia S. C.; Wong, David C. N.; Cheung, Yee Tak Derek; Leung, Doris Y. P.; Lau, Lisa; Lai, Vienna; Lam, Tai-Hing

2015-01-01

The present trial examined the effectiveness of brief interventions for smokers who joined the Hong Kong Quit to Win Contest to quit smoking. A block randomized controlled trial allocated 1003 adult daily smokers to three groups: (i) The TEL group (n = 338) received a 5-min nurse-led telephone counselling; (ii) The SMS group (n = 335) received…

Networks, Netwar, and Information-Age Terrorism

DTIC Science & Technology

1999-01-01

intermediate nodes. • The star, hub, or wheel network, as in a franchise or a cartel structure where a set of actors is tied to a central node or actor...Aviv and Jerusalem. On March 21, a Hamas satchel bomb exploded at a Tel Aviv cafe , killing three persons and injuring 48; on July 30, two Hamas

Development, Implementation, and Assessment of a Distance Module in Endocrine Physiology

ERIC Educational Resources Information Center

Rangel, Elaine Maria Leite; Mendes, Isabel Amelia Costa; Carnio, Evelin Capellari; Alves, Leila Maria Marchi; de Godoy, Simone; Crispim, Juliane de Almeida

2010-01-01

This study aimed to develop, implement, and assess a distance module in endocrine physiology in TelEduc for undergraduate nursing students from a public university in Brazil, with a sample size of 44 students. "Stage 1" consisted of the development of the module, through the process of creating a distance course by means of the Web.…

A Usability Evaluation of a Blended MOOC Environment: An Experimental Case Study

ERIC Educational Resources Information Center

Yousef, Ahmed Mohamed Fahmy; Chatti, Mohamed Amine; Schroeder, Ulrik; Wosnitza, Marold

2015-01-01

In the past few years, there has been an increasing interest in Massive Open Online Courses (MOOCs) as a new form of Technology-Enhanced Learning (TEL), in higher education and beyond. Recognizing the limitations of standalone MOOCs, blended MOOCs (bMOOCs) that aim at bringing in-class (i.e. face-to-face) interactions and online learning…

Economic Literacy in German Speaking Countries and the United States. First Steps to a Comparative Study.

ERIC Educational Resources Information Center

Beck, Klaus; Krumm, Volker

The lack of a German language testing instrument for economic literacy has led to problems for researchers in German-speaking countries to establish the level of economic literacy in those countries. The translation of the 23rd edition (1987) of the Test of Economic Literacy (TEL) into a German version, known as the Wirtschalfliche Bildung Test…

Calendar of Selected Aeronautical and Space Meetings January 1991 Onwards (Calendrier des Manifestations Aeronautiques et Spatiales (Selection) Janvier 1991 et au-dela)

DTIC Science & Technology

1990-12-01

e 39 08 - Physique de l’Atmosph~re et Environnement terrestre 55 09 - Information, Documentation et Informatique 58 10 - Th~rnes g6n6raux...Fax (02) 692 2012 OS UV University of Vienna: Liebigasse 4/3-4, A- 1010 Wien Tel 43.1.43.67.12 Fax 43.1.43.01.97 AU VDE Verband Deutscher

Europe/Latin America Report Science and Technology.

DTIC Science & Technology

1997-01-15

Partners: Mr. W. Horak Siemens A.G. KO AP 313 Otto Hahn Ring 6 D-8000München 83 Tel: 49-89-72223728 Tlx: 521090 Fax: 49-89-63647140 Siemens A.G...operate the equipment, Dr Joao Renato Pinho of the Adolfo Lutz Institute is pursuing studies in molecular hybridization at the University of Lyons, in

Assessment for Effective Intervention: Enrichment Science Academic Program

ERIC Educational Resources Information Center

Sasson, Irit; Cohen, Donita

2013-01-01

Israel suffers from a growing problem of socio-economic gaps between those who live in the center of the country and residents of outlying areas. As a result, there is a low level of accessibility to higher education among the peripheral population. The goal of the Sidney Warren Science Education Center for Youth at Tel-Hai College is to…

Effectiveness of Test-Enhanced Learning (TEL) in lectures for undergraduate medical students

PubMed Central

Ayyub, Aisha; Mahboob, Usman

2017-01-01

Objective: To determine the effectiveness of Test-Enhanced learning as a learning tool in lectures for undergraduate medical students Method: This quantitative, randomized controlled trial included eighty-four students of 4th year MBBS from Yusra Medical & Dental College, Islamabad. The duration of study was from March 2016 to August 2016. After obtaining the informed consent; participants were equally assigned to interventional and non-interventional study groups through stratified randomization. Single best answer MCQs of special pathology were used as data collection instrument after validation. A pre- and post-test was taken from both groups, before and after the intervention, respectively and their results were compared using SPSS version 21. Results: There were 13 male (31%) and 29 female (69%) participants in each study group who showed an equivalent baseline performance on pre-test (p=0.95). Statistically significant difference was found among mean scores of interventional and non-interventional study groups at exit exam (p=0.00). Interventional group also showed a significant improvement in their post-test scores (mean: 17.17±1.59) as compared to pre-test scores (mean: 6.19±1.81). Conclusions: Test-enhanced learning has significant effect on improving the learning of course content delivered to undergraduate medical students through lectures. PMID:29492055

Inquiry-Based Learning and Technology--Supporting Institutional TEL within One Pedagogical Context

ERIC Educational Resources Information Center

Little, Sabine

2008-01-01

Following the establishment of Centres for Excellence in Teaching and Learning in England and Northern Ireland in 2005, several institutions have used these to pursue specific pedagogical approaches at a strategic level, in line with and building on existing institutional strategic thinking. Technology-enhanced learning is often one of the…

Effects of TEL Confusers on Operator Target Acquisition Performance with SAR Imagery

DTIC Science & Technology

1998-12-01

processing known as the theory of signal detection (TSD) (Gescheider, 1985; Green & Swets, 1966; Macmillan & Creelman , 1991; Wilson, 1992). A TSD...localizations (Hacker & Ratcliff, 1979; Macmillan & Creelman , 1991). The index of bias in a target localization task provides a measure of the operator’s...of correct localizations substituted for hits (Macmillan & Creelman , 1991). Receiver Operating Characteristic Curves. In addition to the calculation

Exploring Meaning in Life in the Tel Hai Gifted Children’s Center

ERIC Educational Resources Information Center

Kasler, Jon; Goldfarb-Rivlin, Sima; Levi, Jossef; Elias, Maurice J.

2013-01-01

While high IQ is likely to be an advantage in moral reasoning, it does not guarantee students' putting those morals into practice. A clearly defined sense of purpose grounded in values of social responsibility, exploration of values, and the search for ultimate truths, both personal and collective, is paramount. The Meaning in Life program in…

[Proceedings of the] International Conference on Educational Data Mining (EDM) (3rd, Pittsburgh, PA, July 11-13, 2010)

ERIC Educational Resources Information Center

Baker, Ryan S. J. d., Ed.; Merceron, Agathe, Ed.; Pavlik, Philip I., Jr., Ed.

2010-01-01

The Third International Conference on Data Mining (EDM 2010) was held in Pittsburgh, PA, USA. It follows the second conference at the University of Cordoba, Spain, on July 1-3, 2009 and the first edition of the conference held in Montreal in 2008, and a series of workshops within the AAAI, AIED, EC-TEL, ICALT, ITS, and UM conferences. EDM 2011…

Determination of the Chronic Mammalian Toxicological Effects of TNT (twenty-Four Month Chronic Toxicity/Carcinogenicity Study of Trinitrotoluene (TNT) in the Fischer 344 Rat). Volume 1

DTIC Science & Technology

1984-12-01

the study were also analyzed for nitrate, nitrite and mercury content by TEl. 200 Fischer 344 rats, obtained from Harlan Sprague-Dawley, Madison , WI...Iles Pancreas Pituitary gland Prostate Rectum Salivary gland Sciatic nerve Seminal vesicles Skin, abdominal Spinal cord (cervical, thoracic, lumbar ...Skin, abdominal Spinal cord (cervical, thoracic and lumbar ) Sp I een Sternum Including bone marrow Stomach TIssue masses Thyroids (parathyrolds

A Multilevel System of Quality Technology-Enhanced Learning and Teaching Indicators

ERIC Educational Resources Information Center

Law, Nancy; Niederhauser, Dale S.; Christensen, Rhonda; Shear, Linda

2016-01-01

In this paper we elaborate and extend the work of the EDUsummIT 2015 Thematic Working Group 7 (TWG7) by proposing a set of indicators on quality Technology-Enhanced Learning and Teaching (TEL&T). These indicators are intended as one component of a set of global indicators that could be used to monitor implementation of the Education 2030…

Simulator Adaptation Syndrome Literature Review

DTIC Science & Technology

2004-01-16

SIMULATOR ADAPTATION SYNDROME LITERATURE REVIEW 1517 N. Main Street | Royal Oak, MI 48067 Tel...Simulator Adaptation Syndrome Literature Review 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) 5d. PROJECT NUMBER 5e...describe simulator sickness as a syndrome because it has many complex contributing causes and manifests itself with many potential symptoms. A good

Towards a Science of Command and Control (C2)

DTIC Science & Technology

2005-06-01

Topic: C4ISR/C2 Architecture Associate Professor David H Cropley Systems Engineering & Evaluation Centre, University of South Australia Mawson ...Lakes Campus, Mawson Lakes, SA 5095, Australia Tel: (+618) 8302 3301 Fax: (+618) 8302 5344 Email: david.cropley@unisa.edu.au Report...ADDRESS(ES) Systems Engineering & Evaluation Centre,University of South Australia, Mawson Lakes Campus, Mawson Lakes, SA 5095, Australia, , 8

Venture Capital and Strategic Investment for Developing Government Mission Capabilities

DTIC Science & Technology

2014-01-01

JIEDDO Joint Improvised Explosive Device Defeat Organization NASA National Aeronautics and Space Administration NGA National Geospatial-Intelligence... USDA Investments at Risk Due to Corporation’s Mismanagement, U.S. Department of Agriculture press release, December 2, 1999. 16 V en tu re C ap...2000 agriculture Independent within USDa Limited terminated for lack of effective internal control structure, limited effectiveness In-Q-tel 1999

TMOC: A Model for Lecturers' Training to Management of Online Courses in Higher-Education

ERIC Educational Resources Information Center

Ghilay, Yaron; Ghilay, Ruth

2014-01-01

The study examined a new model called TMOC: Training to Management of Online Courses. The model is designed to train lecturers in higher-education to successfully create, deliver and develop online courses. The research was based on a sample of lecturers, who studied in a course based on the new model at the Mofet Institute in Tel-Aviv (n = 20).…

Interlanguage Pragmatics Study of Compliments among Thai EFL Learners

ERIC Educational Resources Information Center

Worathumrong, Sakulrat; Luksaneeyanawin, Sudaporn

2016-01-01

This study compares how the native speakers of Thai (TTs) and American (AEs) as well as the Thai learners of English as a foreign language with high exposure to English (TEHs) and those with the low exposure (TELs) perform the speech acts of compliments (Cs) by taking the context of age into their consideration. The data were collected by means of…

Measuring and comparing structural fluctuation patterns in large protein datasets.

PubMed

Fuglebakk, Edvin; Echave, Julián; Reuter, Nathalie

2012-10-01

The function of a protein depends not only on its structure but also on its dynamics. This is at the basis of a large body of experimental and theoretical work on protein dynamics. Further insight into the dynamics-function relationship can be gained by studying the evolutionary divergence of protein motions. To investigate this, we need appropriate comparative dynamics methods. The most used dynamical similarity score is the correlation between the root mean square fluctuations (RMSF) of aligned residues. Despite its usefulness, RMSF is in general less evolutionarily conserved than the native structure. A fundamental issue is whether RMSF is not as conserved as structure because dynamics is less conserved or because RMSF is not the best property to use to study its conservation. We performed a systematic assessment of several scores that quantify the (dis)similarity between protein fluctuation patterns. We show that the best scores perform as well as or better than structural dissimilarity, as assessed by their consistency with the SCOP classification. We conclude that to uncover the full extent of the evolutionary conservation of protein fluctuation patterns, it is important to measure the directions of fluctuations and their correlations between sites. Nathalie.Reuter@mbi.uib.no Supplementary data are available at Bioinformatics Online.

Rosalind Driver studentships

NASA Astrophysics Data System (ADS)

1999-11-01

The School of Education at King's College London can now offer funded studentships to those wishing to undertake research in science education. These studentships, which are funded through the generous benefaction of the late Rosalind Driver, can be for a full-time student (over a maximum of three years) or several part-time students (a maximum of six years). Applications from anyone working in science education are welcome but preference will be given to those originating from practising science teachers. Applicants will be expected to register for the award of a MPhil/PhD or EdD and are normally expected to have a first degree. Preliminary ideas about a topic for investigation would also be helpful. Further details and application forms are obtainable from Chiz Dube, School of Education, King's College London, Franklin - Wilkins Building, Waterloo Road, London SE1 8WA (tel: 020-7848-3089, e-mail: chiz.dube@kcl.ac.uk). The deadline for the first round of applications was the middle of October, but preliminary informal enquiries may be made to Dr Jonathan Osborne at the School of Education (tel: 020-7848-3094, e-mail: jonathan.osborne@kcl.ac.uk).

[DR. SHOSHANA SZKOP-FRENKIEL: THE FIRST FEMALE PLASTIC SURGEON IN ISRAEL].

PubMed

Shehory-Rubin, Zipora

2015-11-01

In the history of Israeli medicine, Dr. Shoshana Szkop-Frenkiel is regarded as the first plastic surgeon in the country and among the founders of the profession of plastic surgery. This article describes the long road she traveled, from her acceptance into medical studies in Vilna--at a time when the entry of any woman to the faculty of medicine was strictly limited and of Jewish women in particular; her emigration to Eretz Israel and her struggles as she underwent training in internal medicine at the "Hadassah" Hospital in Tel-Aviv, when she was denied training as a surgeon; and up to the moment she was accepted by the plastic surgery unit of the Tel Hashomer Hospital and became the first such female practitioner in Israel. Dr. Shoshana Szkop-Frenkiel thus fulfilled a childhood dream to become a surgeon at a time when women were excluded from surgery on the grounds that it called for "male" characteristics. This article is intended to illustrate the character of a female doctor pursuing a career in surgery during the time of the British Mandate, to illuminate her professional travails in Israel, and to emphasize her important contribution in the field.

Tangeretin sensitizes SGS1-deficient cells by inducing DNA damage.

PubMed

Chong, Shin Yen; Wu, Meng-Ying; Lo, Yi-Chen

2013-07-03

Tangeretin, a polymethoxyflavone found in citrus peel, has been shown to have antiatherogenic, anti-inflammatory, and anticarcinogenic properties. However, the underlying target pathways are not fully characterized. We investigated the tangeretin sensitivity of yeast (Saccharomyces cerevisiae) mutants for DNA damage response or repair pathways. We found that tangeretin treatment significantly reduced (p < 0.05) survival rate, induced preferential G1 phase accumulation, and elevated the DNA double-strand break (DSB) signal γH2A in DNA repair-defective sgs1Δ cells, but had no obvious effects on wild-type cells or mutants of the DNA damage checkpoint (including tel1Δ, sml1Δ mec1Δ, sml1Δ mec1Δ tel1Δ, and rad9Δ mutants). Additionally, microarray data indicated that tangeretin treatment up-regulates genes involved in nutritional processing and down-regulates genes related to RNA processing in sgs1Δ mutants. These results suggest tangeretin may sensitize SGS1-deficient cells by increasing a marker of DNA damage and by inducing G1 arrest and possibly metabolic stress. Thus, tangeretin may be suitable for chemosensitization of cancer cells lacking DSB-repair ability.

Molecular dynamics studies of the 3D structure and planar ligand binding of a quadruplex dimer.

PubMed

Li, Ming-Hui; Luo, Quan; Xue, Xiang-Gui; Li, Ze-Sheng

2011-03-01

G-rich sequences can fold into a four-stranded structure called a G-quadruplex, and sequences with short loops are able to aggregate to form stable quadruplex multimers. Few studies have characterized the properties of this variety of quadruplex multimers. Using molecular modeling and molecular dynamics simulations, the present study investigated a dimeric G-quadruplex structure formed from a simple sequence of d(GGGTGGGTGGGTGGGT) (G1), and its interactions with a planar ligand of a perylene derivative (Tel03). A series of analytical methods, including free energy calculations and principal components analysis (PCA), was used. The results show that a dimer structure with stacked parallel monomer structures is maintained well during the entire simulation. Tel03 can bind to the dimer efficiently through end stacking, and the binding mode of the ligand stacked with the 3'-terminal thymine base is most favorable. PCA showed that the dominant motions in the free dimer occur on the loop regions, and the presence of the ligand reduces the flexibility of the loops. Our investigation will assist in understanding the geometric structure of stacked G-quadruplex multimers and may be helpful as a platform for rational drug design.

A cognitive perspective on technology enhanced learning in medical training: great opportunities, pitfalls and challenges.

PubMed

Dror, Itiel; Schmidt, Pascal; O'connor, Lanty

2011-01-01

As new technology becomes available and is used for educational purposes, educators often take existing training and simply transcribe it into the new technological medium. However, when technology drives e-learning rather than the learner and the learning, and when it uses designs and approaches that were not originally built for e-learning, then often technology does not enhance the learning (it may even be detrimental to it). The success of e-learning depends on it being 'brain friendly', on engaging the learners from an understanding of how the cognitive system works. This enables educators to optimize learning by achieving correct mental representations that will be remembered and applied in practice. Such technology enhanced learning (TEL) involves developing and using novel approaches grounded in cognitive neuroscience; for example, gaming and simulations that distort realism rather than emphasizing visual fidelity and realism, making videos interactive, training for 'error recovery' rather than for 'error reduction', and a whole range of practical ways that result in effective TEL. These are a result of e-learning that is built to fit and support the cognitive system, and therefore optimize the learning.

The Spacecraft Emergency Response System (SERS) for Autonomous Mission Operations

NASA Technical Reports Server (NTRS)

Breed, Julia; Chu, Kai-Dee; Baker, Paul; Starr, Cynthia; Fox, Jeffrey; Baitinger, Mick

1998-01-01

Today, most mission operations are geared toward lowering cost through unmanned operations. 7-day/24-hour operations are reduced to either 5-day/8-hour operations or become totally autonomous, especially for deep-space missions. Proper and effective notification during a spacecraft emergency could mean success or failure for an entire mission. The Spacecraft Emergency Response System (SERS) is a tool designed for autonomous mission operations. The SERS automatically contacts on-call personnel as needed when crises occur, either on-board the spacecraft or within the automated ground systems. Plus, the SERS provides a group-ware solution to facilitate the work of the person(s) contacted. The SERS is independent of the spacecraft's automated ground system. It receives and catalogues reports for various ground system components in near real-time. Then, based on easily configurable parameters, the SERS determines whom, if anyone, should be alerted. Alerts may be issued via Sky-Tel 2-way pager, Telehony, or e-mail. The alerted personnel can then review and respond to the spacecraft anomalies through the Netscape Internet Web Browser, or directly review and respond from the Sky-Tel 2-way pager.

Principal Leadership for Technology-enhanced Learning in Science

NASA Astrophysics Data System (ADS)

Gerard, Libby F.; Bowyer, Jane B.; Linn, Marcia C.

2008-02-01

Reforms such as technology-enhanced instruction require principal leadership. Yet, many principals report that they need help to guide implementation of science and technology reforms. We identify strategies for helping principals provide this leadership. A two-phase design is employed. In the first phase we elicit principals' varied ideas about the Technology-enhanced Learning in Science (TELS) curriculum materials being implemented by teachers in their schools, and in the second phase we engage principals in a leadership workshop designed based on the ideas they generated. Analysis uses an emergent coding scheme to categorize principals' ideas, and a knowledge integration framework to capture the development of these ideas. The analysis suggests that principals frame their thinking about the implementation of TELS in terms of: principal leadership, curriculum, educational policy, teacher learning, student outcomes and financial resources. They seek to improve their own knowledge to support this reform. The principals organize their ideas around individual school goals and current political issues. Principals prefer professional development activities that engage them in reviewing curricula and student work with other principals. Based on the analysis, this study offers guidelines for creating learning opportunities that enhance principals' leadership abilities in technology and science reform.

Effect of sub-Tenon's and peribulbar anesthesia on intraocular pressure and ocular pulse amplitude.

PubMed

Pianka, P; Weintraub-Padova, H; Lazar, M; Geyer, O

2001-08-01

To compare the effect of peribulbar and sub-Tenon's anesthesia on intraocular pressure (IOP) and ocular pulse amplitude (OPA) in the injected eye and the fellow noninjected (control) eye. Tel Aviv Medical Center, Tel Aviv, Israel. This prospective study measured IOP and OPA at baseline and 1 and 10 minutes after administration of lidocaine anesthesia in 40 consecutive adult patients having elective cataract surgery. The IOP remained stable throughout the study with both modes of anesthesia. One minute after injection of the anesthetic agent, the OPA was significantly decreased in the injected eyes in both the sub-Tenon's (24%; P < .05) and peribulbar (25%; P < .05) groups. The decrease in the OPA in the sub-Tenon's group (14%; P < .05) was detectable after 10 minutes in the control eyes. In the peribulbar anesthesia group, the OPA in the control eyes increased significantly (9%; P < .05) 1 minute after injection of the anesthetic agent, returning to preinjection levels 10 minutes after the injection. The OPA in the eyes in which lidocaine was injected decreased significantly in both the sub-Tenon's and peribulbar groups. These findings have implications for the management of patients whose ocular circulation may be compromised.

Exercise for frail elders Exercise for frail elders Best-Martini Elizabeth Kim A Product Botenhagen-Di Genova Human Kinetics £24.50 0 73603 687 3 0736036873.

PubMed

2003-09-01

Department of Health Publications Free 208 pp This guide provides practical advice on how to obtain information, services and equipment. It is aimed at people who are older, disabled or who have mental health problems and those who support them. Copies are available in Braille, audio cassette, disk, large print and in a range of languages. Tel: 0800 555777. www.doh.gov.uk /disabledguide.

WRKY Transcription Factors: Key Components in Abscisic Acid Signaling

DTIC Science & Technology

2011-01-01

Review article WRKY transcription factors : key components in abscisic acid signalling Deena L. Rushton1, Prateek Tripathi1, Roel C. Rabara1, Jun Lin1...May 2011. *Correspondence (Tel +605 688 5749; fax +605 688 5624; email paul.rushton@sdstate.edu) Keywords: abscisic acid, WRKY transcription factor ...seed germination, drought, abiotic stress. Summary WRKY transcription factors (TFs) are key regulators of many plant processes, including the responses

An Analysis of Proposed and Current Regulations Concerning Lobbying Costs in Department of Defense Contracts.

DTIC Science & Technology

1984-06-01

a reduction in industry participation in the defense mobilization base, and a limiting of capital available for investment in producti- vity...FAR proposals, it appears that this stratgy has b-2n successful to a large degree. Thor,-, ar , how-vr, still areas where critics believe that further...appropriations. Lobbying includes but is not limited to personal discussions or conferences, advertising , sending tel- egrams, engaging in telephonic

Computer-aided Human Centric Cyber Situation Awareness

DTIC Science & Technology

2016-03-20

in Video, IJCAI: International Joint Conf. on Artificial Intelligence . 16-JUL-11, . : , Kun Sun, Sushil Jajodia, Jason Li, Yi Cheng, Wei Tang...Cyber-Security Conference, June 2015. 2. V.S. Subrahmanian, Invited Speaker, Summer School on Business Intelligence and Big Data Analysis, Capri, Italy... Cybersecurity Conference, Yuval Ne’eman Workshop for Science, Technology and Security, Tel Aviv University, the Israeli National Cyber Bureau, Prime

Congressional Liaison Offices of Selected Federal Agencies

DTIC Science & Technology

2010-09-03

Offices of Selected Federal Agencies Congressional Research Service 1 Legislative Branch Congressional Budget Office Edward “Sandy” Davis...VA 22060-6221 Tel: (703) 767-5264 Fax: (703) 767-6312 http://www.dla.mil/ Defense Security Cooperation Agency Vanessa Murray Director...Fax: (202) 685-6077 http://www.marines.mil/units/hqmc/Pages/ default.aspx For Senate offices: Lt. Col. Harold R. Van Opdorp U.S.M.C. Deputy

Regulation and Function of Cytokines that Predict Prostate Cancer Metastasis

DTIC Science & Technology

2011-08-01

Ph.D. Cedar-Sinai Medical Center Los Angeles, CA 90048 W81XWH-09-1-0503 11 bhowmickn@cshs.org Table of Contents Introduction...Professor, Medicine Uro -Oncology Research Program Samuel Oschin Comprehensive Cancer Institute Cedars-Sinai Medical Center 8750 Beverly Blvd...Atrium 103 Los Angeles, CA 90048 Tel: (310) 423-5992 Fax: (310) 423-8543 Email: bhowmickn@cshs.org Please note the grant has been transferred

French Research in Acoustics and Signal Processing: Report on Introductory Visit

DTIC Science & Technology

1986-05-01

CEPHAG (Centre d’Etude des Phenomenes Aleatoires et Geophysiques ), which is associated with the Institut National Polytechnique at Grenoble. We were...measurement programs. Centre d’Etude des Phenomenes Aleatoires et Geophysiques (CEPHAG), Institut National Polytechnique, Universite de Grenoble, 23 May...69288 Lyon Cedex, France, Tel 72.32.50.67. CENTRE D’ETUDE DES PHENOMENES ALEATOIRES ET GEOPHYSIQUES (CEPHAG), Grenoble. Prof. J. L. Lacoume

Earth Observations taken by STS-115 crewmember

NASA Image and Video Library

2006-09-19

S115-E-07595 (19 Sept. 2006) --- A crewmember aboard the Space Shuttle Atlantis recorded this digital still image of part of the eastern Mediterranean area. The Gulf of Suez, Gulf of Aqaba, Dead Sea, Tel Aviv and Jerusalem all are visible in the upper left quadrant. Jordan is in the lower left quadrant. The Golan Heights and Haifa appear in the lower right quarter.

Integrating Trends in Decision-Making Research

DTIC Science & Technology

2016-03-01

Address correspondence to Cleotilde Gonzalez, Department of Social and Decision Sciences, Dynamic Decision Making Lab, Carnegie Mellon University...Cleotilde Gonzalez, Carnegie Mellon University, and Joachim Meyer, Tel-Aviv University Journal of Cognitive Engineering and Decision Making 201X, Volume XX...Number X, Month 2016, pp. 1 –3 DOI: 10.1177/1555343416655256 Copyright © 2016, Human Factors and Ergonomics Society. at CARNEGIE MELLON UNIV LIBRARY

The Impact of the AT&T (American Telephone and Telegraph) Divestiture on the Strategic Air Command.

DTIC Science & Technology

1984-01-01

the corporate tel- ecommunications manager, think of the impact on the military communicator. For a corporation, poorly planned, installed, and main...tained telecommunications equipment and services may mean increased cost or lost profits. For the military communicator, the same prob- lems can mean ...effective telecommunications systems available, even if it means turning our backs on past methods and relationships with vendors. I 4 NOTES -CHAPTER

Solution Spraying of Poly(methyl methacrylate) Blends to Fabricate Micro-textured, Superoleophobic Surfaces (PREPRINT)

DTIC Science & Technology

2011-01-01

S. Chhatre a , Joseph M. Mabry b , Robert E. Cohen a and Gareth H. McKinley c a Department of Chemical Engineering , Massachusetts Institute of...Department of Mechanical Engineering , Massachusetts Institute of Technology, Cambridge 02139 Corresponding Authors: Tel.: (617) 253-3777 (R.E.C.); (617...the morphological properties, is of interest in a number of applications including sensors, filtration, drug release, tissue engineering scaffolds

Simulation of Aircraft Deployment Support

DTIC Science & Technology

2003-03-01

Dassault Aviation Military Customer Support Division 78, Quai Marcel Dassault Cedex 300 92552 St Cloud Cedex France Tel.: 33 147 1163 23 Fax.: 33 147...Deployment Support" (SADS) was developed by the Military Customer Support Division of Dassault Aviation to perform simulations for logistics deployment and...and support Chain Management for the management of the logistics resources (replenishment of consumables and repair of parts, inventory management

Evaluation of the Transcribed Weather Broadcast (TWEB) System and Alternatives. Volume I. Technical and Operational Assessment and Cost Summary.

DTIC Science & Technology

1980-08-01

objectives of this project were to perform an evaluation of the effectiveness of the Transcribed Weather Broadcast (TWEB) System in its current national con... performance of TWEB at selected represent- ative field locations. In addition, discussions concerning the review and appraisal of TWEB and Pilots...Briefing Surface TELCO Telephone Company TEL-TWZB telephone access to TWEB TV television TWEB Transcribed Weather Broadcast UNICOM Aeronautical Advisory

Room Temperature Deposition Processes Mediated By Ultrafast Photo-Excited Hot Electrons

DTIC Science & Technology

2014-01-30

mechanical through resonant energy transfer. The average electron temperature (Tel) during τ2 evolves as energy is lost through optical and acoustic ...through ballistic collisions and acoustic phonons. The large difference in heat capacities between electrons and the substrate leads to negligible...temperature pyrometer indicated only a ~30oC temperature gradient between the thermocouple location and the topside of the sample which faced the

Special Session on Adaptive Optics in Russia and China. Volume 23

DTIC Science & Technology

1995-01-01

Fisica Aplicada. Universidad de Cantabria. 39005. SANTANDER. SPAIN. Tel: 42-201445. Fax: 42-201402. 1.- INTRODUCTION To estimate the centroid of a light...Lia M. Zerbino ##, Eduardo Aguirre +, Anibal P. Laquidara ++ and Mario-Garavaglia ft. Centro de Investigaciones Opticas (CIOp) CC 124 Correo Central...Professor at Universidad Nacional dt La Plata and CONICET Engiuneer. C (lOp belongs to Consejo Nacional de Investigaciones Cientificas y Ticnicas (CONICET

Pragmatic and Idiosyncratic Acts in Human Everyday Routines: The Counterpart of Compulsive Rituals

DTIC Science & Technology

2010-03-25

Mort3, and David Eilam1 1Department of Zoology, Tel-Aviv University, Ramat-Aviv 69978, Israel 2Departments of Psychology and Anthropology, Washington...Introduction Repetitive actions are prevalent in normal and abnormal behavior [7]. In normal behavior, repetitive performance takes the form of...unconscious as repository of chronic goals and motives, in: Gollwitzer PM, Bargh JA, Editors. The psychology of action: Linking cognition and

Ada Compiler Validation Summary Report: Certificate Number: 890420W1. 10074 International Business Machines Corporation, IBM Development System for the Ada Language MVS Ada Compiler, Version 2.1.1 IBM 4381 (Host and Target)

DTIC Science & Technology

1989-04-20

20. ARS1AAI . (Contimne on reverse side olnetessary *rwenPtif) by bfoci nur~be’) International Business Machines Corporation, IBM Development System...Number: AVF-VSR-261.0789 89-01-26-TEL Ada COMPILER VALIDATION SUMMARY REPORT: Certificate Number: 890420W1.10074 International Business Machines...computer. The compiler was tested using command scripts provided by International Business Machines Corporation and reviewed by the validation team. The

The Knock-Limited Performance of Fuel Blends Containing Aromatics V : N-Propylbenzene, N-Butylbenzene, Isobutylbenzene, M-Xylene, and 1-Isopropyl-4-Methylbenzene

NASA Technical Reports Server (NTRS)

Meyer, Carl L.; Branstetter, J. Robert

1946-01-01

Results are reported of knock-limited tests of five aromatics, each individually blended with selected base fuels and tested with and without TEL, using 17.6, F-4, and F-3 small-scale engines. The five aromatics rated in the following order of decreasing antiknock effectiveness at fuel/air ratio 0.10: m-xylene, 1-isopropyl-4-methylbenzene, n-propylbenzene, isobutylbenzene, and n-butylbenzene.

The role of vasoactive intestinal peptide in neuroprotection: Professor Illana Gozes is interviewed by Emma Quigley.

PubMed

Gozes, Illana

2007-06-01

Professor Illana Gozes was interviewed by Emma Quigley (Senior Editor, Expert Opinion) on 17(th) April 2007. Professor Illana Gozes BSc, PhD holds the titles of Professor of Clinical Biochemistry; The Lily and Avraham Gildor Chair for the Investigation of Growth Factors; Director of Adams Super Center for Brain Studies and Levi-Edersheim-Gitter fMRI Institute; Head of the Dr Diana and Zelman Elton (Elbaum) Laboratory for Molecular Neuroendocrinology, Tel Aviv University and Chief Scientific Officer, Allon Therapeutics, Inc., Vancouver BC, Canada. Professor Gozes has served as a member (or chair) of several faculty, university or national and international committees and she currently serves on the Board of Directors of Allon Therapeutics, the Scientific Review Board of the ISOA, and is the Editor-in-Chief of the Journal of Molecular Neuroscience. Professor Gozes has received a number of scientific awards for her work including the Landau Award for an excellent PhD dissertation, the Juludan Prize and the Teva Founders Prize for exceptional scientific studies that may lead to biotechnology developments as well as the Bergmann Prize and the Neufeld award for outstanding/leading US-Israel BSF grant proposals, and has published extensively in the fields of molecular neuroscience and neuroprotection (> 200 scientific manuscripts). She is co-inventor of > 15 patents and applications, including the composition of matter patent on AL-108 and AL-208, Allon's lead compounds. Professor Gozes received a BSc from Tel Aviv University, a PhD from The Weizmann Institute of Science and was a Weizmann Postdoctoral Fellow at Massachusetts Institute of Technology, Research Associate/Visiting Scientist at the Salk Institute and the Scripps Clinic and Research Foundation, a Senior Scientist/Associate Professor at the Weizmann Institute and a Fogarty-Scholar-in-Residence at the National Institutes of Health (USA). Professor Gozes directs a very active research laboratory at Tel Aviv

Reliability of body temperature measurements in hospitalised older patients.

PubMed

Giantin, Valter; Toffanello, Elena D; Enzi, Giuliano; Perissinotto, Egle; Vangelista, Stefania; Simonato, Matteo; Ceccato, Corrado; Manzato, Enzo; Sergi, Giuseppe

2008-06-01

To compare different body temperature assessment methods in older people and to assess the role of cognitive and functional characteristics in temperature recordings. Axillary gallium-in-glass thermometers are commonly used. Their accuracy depends on the proper placement of the device and their permanence in place for eight minutes. With adequate instruction, well-functioning patients can measure their axillary temperature by themselves, while in cognitively and functionally impaired older people, inadequate understanding of instructions and misplacement of the thermometer might determine significant recording errors. Electronic ear and axillary temperature measurements are faster, but their accuracy has not been demonstrated convincingly with older people. Patients (n = 107; aged 65-104 years) were recruited. Barthel Index and Short Portable Mental Status Questionnaire (SPMSQ) scores were obtained for each patient. Temperature readings were obtained using: the axillary gallium-in-glass thermometer, with (T(nurse)) and without (T(self)) the nurse's assistance; the electronic axillary thermometer (T(el)) and the infrared tympanic thermometer (T(tymp)). The T(nurse) was considered as the reference method. Mean difference and standard deviation (mean +/- SD) in temperature recordings between the different techniques and T(nurse) differed significantly from zero for T(self) (-0.40 SD 0.42) and T(tymp) (+0.19 SD 0.48). No significant differences in temperature recordings emerged between T(nurse) and T(el). In simple linear regression models, the difference between T(self) and T(nurse) significantly correlated with age, gender, SPMSQ score and Barthel Index. Multiple linear regression analysis showed an underestimation of body temperature in older patients with cognitive impairments. Unassisted gallium-in-glass axillary temperature assessment is inadequate, in older patients. The differences between T(self) and T(nurse) are significantly influenced by age and mental

Design and implementation of the Exercise for Health trial -- a pragmatic exercise intervention for women with breast cancer.

PubMed

Hayes, Sandra; Rye, Sheree; Battistutta, Diana; Yates, Patsy; Pyke, Chris; Bashford, John; Eakin, Elizabeth

2011-07-01

Exercise for Health was a pragmatic, randomised, controlled trial comparing the effect of an eight-month exercise intervention on function, treatment-related side effects and quality of life following breast cancer, compared with usual care. The intervention commenced six weeks post-surgery, and two modes of delivering the same intervention was compared with usual care. The purpose of this paper is to describe the study design, along with outcomes related to recruitment, retention and representativeness, and intervention participation. Women newly diagnosed with breast cancer and residing in a major metropolitan city of Queensland, Australia, were eligible to participate. Consenting women were randomised to a face-to-face-delivered exercise group (FtF, n = 67), telephone-delivered exercise group (Tel, n = 67) or usual care group (UC, n = 60) and were assessed pre-intervention (5-weeks post-surgery), mid-intervention (6 months post-surgery) and 10 weeks post-intervention (12 months post-surgery). Each intervention arm entailed 16 sessions with an Exercise Physiologist. Of 318 potentially eligible women, 63% (n = 200) agreed to participate, with a 12-month retention rate of 93%. Participants were similar to the Queensland breast cancer population with respect to disease characteristics, and the randomisation procedure was mostly successful at attaining group balance, with the few minor imbalances observed unlikely to influence intervention effects given balance in other related characteristics. Median participation was 14 (min and max: 0 and 16) and 13 (min and max: 3 and 16) intervention sessions for the FtF and Tel, respectively, with 68% of those in Tel and 82% in FtF participating in at least 75% of sessions. Participation in both intervention arms during and following treatment for breast cancer was feasible and acceptable to women. Future work, designed to inform translation into practice, will evaluate the quality of life, clinical, psychosocial and

14C dates from Tel Rehov: Iron-Age chronology, pharaohs, and Hebrew kings.

PubMed

Bruins, Hendrik J; van der Plicht, Johannes; Mazar, Amihai

2003-04-11

Stratified radiocarbon dates provide an independent chronological link between archaeological layers and historical data. The invasion by Pharaoh Shoshenq I (Shishak) is a key historical synchronism, approximately 925 B.C.E., mentioned in both Egyptian inscriptions and the Hebrew Bible. The list of places raided by Shoshenq, mentioned at Karnak (Egypt), includes Rehov (Israel). The site yielded a consistent series of radiocarbon dates from the 12th to 9th century B.C.E. Our results (i) suggest a revised Iron-Age chronology; (ii) date an archaeological stratum to Shoshenq's campaign; (iii) indicate the similarity of "Solomonic" and "Omride" pottery; and (iv) provide correlation with Greece and Cyprus.

DoD Use of Commercial Acquisition Practices When They Apply and When They Do Not

DTIC Science & Technology

2015-10-01

A number of organizations—including the Defense Business Board, some think tanks and some in Congress—have encouraged or recommended greater use...simultaneously avoiding discourag- ing commercial firms from doing business with DoD by ask- ing for more information than they are willing to provide...in- vestments through In-Q-Tel and increased emphasis on the productivity of programs like the Small Business Innovative Research program. The DoD

Workshop on the Road to Room Temperature Superconductivity

DTIC Science & Technology

1993-01-14

703-693-1695 650 Harry Road San Jose, CA 95120 Mitzi , Dr. David Tel: 408-927-2434 IBM, Thomas J. Watson Research Fax: 408-927-2100 Center P. 0. Box 218...6:00 Kivelson Fisk: Mitzi : Gorkov: comments 7:30 - 9:30 urphl Torrance - conductivity and superconductivity (oxides) Williams: conductivity and...should develop a better gleanedfromexperimentandtheoryasguides. D. Mitzi (IBM Yorktown Heights) dis- theoretical understanding of highly corre- As the

Dollar Summary of Federal Supply Classification and Service Category by Company, FY84, Part 3 (4610-5925).

DTIC Science & Technology

1984-01-01

TECHNOLOGY INC TEXAS USAF AIRCRAFT MAINTENANCE & REPAIR SHOP EQUIP 454 MENSOR CORPORATION TEXAS NAVY AIRCRAFT MAINTENANCE & REPAIR SHOP EQUIP 37 MICRO DYNAMICS...VAULT COMPANY INC CALIFORNIA DLA BUILDING GLASS TILE BRICK AND BLOCK 8 FSC TOTAL 1C.776 3530 OFFICINA DE SERVICIOS MULTIPLE HONDURAS ARMY PIPE AND...EXCEPT AIRBORNE 731 CONTRACTOR TOTAL 115 MICPO CONSULTANTS INC CALIFORNIA ARMY RADIO TV EQUIPMENT EXCEPT AIRBORNE 193 MICRO -TEL CORPORATION MARYLAND NAVY

Development of a Combination Therapy for Prostate Cancer by Targeting Stat3 and HIF-1alpha

DTIC Science & Technology

2011-07-01

isolated several novel molecules from Chinese herbal medicines. After activity tests of these molecules, we found one compound, TEL, that is a...research plan with three aims to expand these efforts. (1) To isolate and synthesize additional novel compounds from Chinese herbal medicines for... supplemented with 10% FBS, 100 units/ml penicillin, and 100 units/ ml streptomycin and maintained in a 378C CO2 incubator. 2 Reddyet al. The Prostate

Issues in Intelligence Production: Summary of Interviews with Canadian Managers of Intelligence Analysts

DTIC Science & Technology

2010-12-01

la Reine (en droit du Canada), telle que représentée par le ministre de ...organisationnelles, ainsi qu’aux préjugés des analystes et des organismes du renseignement. Un tel constat exige la tenue d’un examen en profondeur de la ...processus de production du renseignement que l’on pourrait expliquer par la mise en application des connaissances et des méthodes acquises dans

The Infernal Machine: The Use of Improvised Explosive Devices (IED) against U.S. Forces

DTIC Science & Technology

2011-03-22

abandoned works near wells and springs; near flagstaffs, magazines, telegraph offices, in carpet bags, baiTels of flour , etc .... ".""vii Accurate...REPORT DOCUMENTATION ·PAGE Form Approved OMB No. 0704-0188 Public reporting burden for this collection of information Is estimated 10 average 1 hour...reviewing !he collec!ion of information. Send comments regarding this burden estimate or any other aspect of this collection of lnformetlon, including

Computational Characterization of Electromagnetic Field Propagation in Complex Structures

DTIC Science & Technology

1998-04-10

34Computational characterization of electromagnetic field propagation in complex structures", DAAH01-91-D-ROOS D.O. 59. Dr. Michael Scalora performed the...Development, and Engineering Center, Bldg. 7804, Room 242 Redstone Arsenal, Alabama 35898-5248 USA Dr. Michael Scalora Quantum Optics Group Tel:(205...scheduled to appear. They are: (1) M. Scalora , J.P. Dowling, A.S. Manka, CM. Bowden, and J.W. Haus, Pulse Propagation Near Highly Reflective