Science.gov

Sample records for nederlands huisartsen genootschap

  1. [NHG guideline 'Deep-vein thrombosis and pulmonary embolus'].

    PubMed

    de Jong, Jip; Lucassen, Wim A M; Geersing, Geert-Jan; Burgers, Jako S; Wiersma, Tjerk

    2015-01-01

    The revised Dutch College of General Practitioners (Nederlands Huisartsen Genootschap [NHG]) guideline 'Deep-vein thrombosis and pulmonary embolus' includes recommendations for the treatment of patients with deep-vein thrombosis (DVT) and thrombophlebitis, and for the exclusion of pulmonary embolism (PE). The general practitioner (GP) can exclude the presence of DVT or PE in some patients by using a decision rule and a D-dimer test. When using D-dimer test as a point-of-care test, meticulous care is essential during the test procedure and storage of blood. The GP can treat many patients with DVT; the NHG guideline does not advise use of direct oral anticoagulants. In the case of an isolated DVT in the calf, treatment with anticoagulants or ultrasound follow-up can be chosen in consultation with the patient or on the basis of regional agreements. In the case of patients with superficial thrombophlebitis, a wait-and-see approach is usually sufficient.

  2. [The readers of the Nederlands Tijdschrift voor Geneeskunde].

    PubMed

    Lagerwij, E W

    1993-02-20

    In order to establish the reach, the reading frequency and the appreciation of the Nederlands Tijdschrift voor Geneeskunde, a telephone inquiry was conducted among a random sample of specialists, general practitioners, registrars and pharmacists in the Netherlands. The response amounted to 81.5% (n = 1515). Of the respondents, 94% received the Journal, and two-thirds read it every week. Eight out of ten saved the Journal, five even all volumes. The reading frequency varied greatly from one section to another. Of those who read the Journal at all, 74% always or often read the clinical lesson and 6% the original articles. Although, due to increasing specialization (in width and in depth), it is becoming increasingly difficult to satisfy all readers, the appreciation of the articles is high.

  3. [Errors in literature references in the Nederlands Tijdschrift voor Geneeskunde].

    PubMed

    Hobma, S O; Overbeke, A J

    1992-03-28

    Literature references contain a considerable number of inaccuracies, both in citations and in quotations. We investigated the accuracy of quotations and references in Nederlands Tijdschrift voor Geneeskunde. We checked at random 100 references of articles presented for publication during a period of 4 weeks using Index Medicus. The citation and quotation of another 100 references (50 with a reading list of less than 13, and 50 with a reading list of more than 24 articles) of published original articles were checked, using the original article. In the references of articles presented for publication 70% contained one or more inaccuracies. In the published articles 31% was not completely correct. In 5% these errors prevented immediate identification of the cited article. In one of every three articles a citation error was made: 5 trivial errors, 16 slightly misleading and 12 seriously misleading errors were found. We could not find a relation between the number of citation errors and the length of the reading list. The original source was not cited in 8 articles. Our conclusion is that the number of inaccuracies, in references as well as in citations, is high; authors should check this part of their articles more carefully. Notably the use of multiple references after a sentence with a number of statements is to be avoided.

  4. [The clinical lesson in the Nederlands Tijdschrift voor Geneeskunde in the last 40 years].

    PubMed

    Maas, K L; Lockefeer, J H

    1997-01-04

    'Lessons of the Week' have been published in Nederlands Tijdschrift voor Geneeskunde since 1928. They consist of a clinical patient demonstration on paper but with the structure and the wording appropriate for a college theater. These lessons are read by three quarters of the journal's readership. They are usually written by senior clinicians.

  5. [Podcasts at The Nederlands Tijdschrift voor Geneeskunde, a first new product].

    PubMed

    2008-06-21

    Podcasts become increasingly available for many biomedical journals. Since the beginning of this year the Nederlands Tijdschrift voor Geneeskunde (Dutch Journal of Medicine) has been uploading podcasts on a weekly basis. With this the journal offer its readers audio summaries and interviews with authors for free (www.ntvg.nl).

  6. [Original articles in the Nederlands Tijdschrift voor Geneeskunde in the last 40 years].

    PubMed

    Maas, K L; Overbeke, A J

    1997-01-04

    Original articles offer the reader of the Nederlands Tijdschrift voor Geneeskunde information about Dutch scientific research. These readers are selective but appreciative. The emphasis has shifted in the last 40 years from case histories, introduction of new techniques, literature studies and opinions, to qualitatively and methodologically adequate numerical studies, with strictly arranged presentation. The numbers of patients per study have increased substantially, and statistical processing has grown more extensive. Cost-benefit analyses appeared. The number of prospective studies remained constant.

  7. [The dawn of a smoke-free leisure industry in The Nederlands].

    PubMed

    Verheugt, F W A; Zaat, J O M; de Leeuw, P W

    2008-06-28

    From the 1st of July 2008 the Dutch smoking ban for public spaces will be extended to hotels, restaurants and bars. The ban is a result of a 2003 Health Council report in which it was concluded that the annual incidence of deaths due to passive smoking is considerable. Based on these numbers, smoking in public spaces is prohibited since 2004. In a society where smoking in public spaces is prohibited, the harm of passive smoking will decrease. In this issue of The Nederlands Tijdschrit voor Geneeskunde (Dutch Journal of Medicine) a number of articles are dedicated to the subject of smoking.

  8. [Editing of articles accepted for publication by the Nederlands Tijdschrift voor Geneeskunde].

    PubMed

    Walvoort, H C

    1997-01-04

    The Nederlands Tijdschrift voor Geneeskunde has been publishing medical science in Dutch for 140 years. To bridge the gap between the specialist science and the general medical reader several sections in the accepted papers have to be clarified, simplified and shortened by post acceptance editing. The style and language of the authors is treated with respect. Changes are made if the article does not comply with internationally accepted rules on scientific reporting, if the article can not be understood using currently authoritative general and medical books of reference, and if its language does not comply with generally accepted Dutch rules for grammar and spelling.

  9. [140 years Nederlands Tijdschrift voor Geneeskunde. 140 volumes: looking back, looking in and looking forward].

    PubMed

    van Gijn, J

    1997-01-04

    The Nederlands Tijdschrift voor Geneeskunde was founded in 1856 when five of the nine medical journal in the Netherlands decided to join hands and launch a new medical weekly (in Dutch). About 800 manuscripts are now submitted each year, most of which are peer reviewed before acceptance. The editorial board consists of about twenty medical specialists who have agreed to carry out the bulk of the peer review for a period of three years each. After retirement from the editorial board, they are a lifelong member of the Association of the Dutch Journal of Medicine. After acceptance, articles are thoroughly scientifically and linguistically edited to ensure that the general medical readership will understand them. About 50% of the accepted papers are published within twenty weeks. In the near future the journal pages will have more illustrations and more coloured ones, educative panels, and a digest of Dutch research published in international journals.

  10. [Consequences of the new changes in Dutch spelling for the Nederlands Tijdschrift voor Geneeskunde].

    PubMed

    van Nimwegen, W J; Los, M L C; van den Eerenbeemt, A M M; Kabos, M

    2006-08-05

    At the end of 2005, a new edition of the Woordenlijst Nederlandse taal (List of words in the Dutch language, also referred to as the Green booklet) appeared with a few adjustments to the spelling changes implemented in 1995. These adjustments led to considerable excitement in the media. The new spelling rules and the new List of words have consequences for the style of the articles in the Nederlands Tijdschrift voor Geneeskunde (NTvG). The most important changes concern the use of lower case in combinations containing a proper name (for example, 'watson-jones-artrodese' instead of 'Watson-Jones-artrodese'). Certain abbreviations are also to be written in lower case from now on ('ecg' and 'hiv'). Finally, the rule for the intermediate 'n' in Dutch words such as 'paarde(n)bloem' has been reversed: one is now to write 'paarden-bloem' instead of' 'paardebloem'. Thanks to the greater availability of electronic spelling control programmes and the availability of all previous volumes of the NTvG in digital form, it will be easier for the authors of medico-scientific articles in the Dutch language to achieve a uniform spelling. The new rules were implemented officially on 1 August 2006.

  11. [An article for the Nederlands Tijdschrift voor Geneeskunde (Dutch Journal of Medicine)?].

    PubMed

    van Gijn, J

    2001-01-06

    Original articles are the backbone of this journal, as with any scientific journal. The Nederlands Tijdschrift voor Geneeskunde stimulates submissions in this category of articles by offering an annual prize for young authors. On the other hand 30-40% of original articles has to be turned away by the editors, because of vital short-comings. The subject matter can be unsuitable, such as details about organisation of health care or a highly specialised topic. More often the methods are at fault. Common problems are: lack of a proper research question, result of medical or surgical treatment without a control group, use of a questionnaire, poor validity because of bias in selection of patients, circular reasoning in the assessment of a diagnostic test, or an inappropriate measure of outcome. We urge prospective authors to seek advice from a clinical epidemiologist or at least from a colleague with experience in clinical research before embarking on a clinical study. If such help is difficult to obtain the editors are prepared to act as intermediary between authors and methodological experts.

  12. [Reasons for rejection of articles vor publication in the Nederlands Tijdschrift voor Geneeskunde in 1990].

    PubMed

    Kan, C C; Lockefeer, J H; Overbeke, A J

    1991-05-11

    To deduce recommendations for authors which decrease the rejection probability we investigated retrospectively which reasons were mentioned in 1990 by the editorial board of the 'Nederlands Tijdschrift voor Geneeskunde' when it rejected original articles, reviews, clinical lessons and case reports, and whether length of the article, professional status of the first author, most relevant specialism and origin of the article influenced the rejection probability. Out of 547 articles 38% (208) were rejected; case reports were rejected most often (49%), reviews least often (33%). Peer review of original articles was the most thorough, of case studies the least. The most frequent reason for rejection in all categories was 'substantial shortcomings', particularly in the original articles (80%). Rejection of clinical lessons and case studies was relatively often due to criteria concerning the clinical message. Both rejected and accepted articles on average exceeded the length limit. Professional status and specialism were associated with a difference in rejection probability (chi 2, p less than 0.05). Specialists had the lowest rejection probability (31%). Nonspecialists benefited from specialist supervision. Articles originating from non-academic institutions were more often rejected than articles from academic centres. We advise authors to judge their articles by means of the criteria mentioned. Consultation of (methodological) experts, literature data bases, and (or) the editorial board can improve their chances. Non-specialists can benefit from the experience and expertise of specialists. In general, scientific attitude and willingness to alter the article according to editorial advice appear to have beneficial results.

  13. [A mere assistant, in every respect subordinate to the physician. Vicissitudes of emancipating 'heilgymnasten' in the Netherlands in the late 19th century].

    PubMed

    Terlouw, T J

    1994-01-01

    During the eighties of the 19th century several physical education teachers who were engaged in physical therapy activities, so called 'heilgynasten', believed that only a solid organization of serious, educated and well-trained heilgymnasten could bring about a positive change in the situation at hand in the field of physical therapy. On September 1st 1889 the 'Genootschap ter beoefening van de Heilgymnastiek in Nederland' ('Society for practising heilgymnastiek in the Netherlands') was founded. The main aim of its members was to establish a state-exam, a public trainingschool as well as to ensure proper legislation for this 'new' profession. In this paper the focus of attention is on the founding of the 'Genootschap' and the reactions it provoked from organizations and practitioners in the fields of physical education and medicine during the first years of its existance. One could say that at first the 'Genootschap' was tolerated. Several well-known Dutch physicians joined the 'Genootschap' as 'extraordinary-member'. Very soon however, some physicians came to see the activities of this organization as a threat to the process of differentiation and specialization in the field of orthopaedic surgery that had just began. They emphasized that the 'heilgymnasten' who worked relatively independent from physicians in the field of physical therapy had no legal status; in fact they argued that these practitioners were actually breaking the law. A solution to these problems was sought through law-suits against 'heilgymnasten' to ensure that they would only practise physical therapy under supervision of physicians. In a next article the plight of one of the Dutch 'heilgymnasten', Hendrik Soeter, who can be considered as a 'victim' of this strategy, will be discussed in more detail. The Dutch 'heilgymnasten' did finally gain a legal status for their profession, but they had to wait for that untill more than fifty years after the foundation of the 'Genootschap'.

  14. [Celebration speech marking the 150th anniversary of the Vereniging Nederlands Tijdschrift voor Geneeskunde (Association Dutch Journal of Medicine)].

    PubMed

    Kennedy, J C

    2007-02-17

    The Nederlands Tijdschrift voor Geneeskunde (NTvG [Dutch Journal of Medicine]) celebrates its 150th anniversary this year. J. van der Meer and S.van 't Hofare the editors of a jubilee book issued to mark the occasion. Two earlier books, issued for the 50th and 100th anniversary of the journal, focused primarily on the history of the association of editors which publishes the NTvG. Unlike these books, a large portion of the current jubilee book is devoted to the history of medicine in the Netherlands in the last 50 years. Of greater importance is that the authors reflect on the relationship between the NTvG, the medical profession and society at large. This relationship has intensified since the 1960's. The NTvG has accomplished its goal of being a general medical journal, but lacks 'the voice of the patient' and editorial comments on current social issues. With respect to the physician-patient relationship, the Netherlands has succeeded more than other countries in diminishing the gap between these two partners. The way the Dutch have dealt with the issue of euthanasia is a clear example. But as to the role of the physician in society, the loss of position and authority, increasing professionalism and specialisation and reluctance to engage in social and ethical debate for fear of losing impartiality have caused the medical profession to assume a marginal position in society, even with respect to its own needs as a group of professionals. At present, there is a clear need for physician citizenship that engages in a broad spectrum of social responsibilities in a professional context.

  15. [Drug advertising as communication between the pharmaceutical industry and the physician: advertisements for psychotropic drugs in the Dutch medical journal, Nederlands Tijdschrift voor Geneeskunde, 1900-1940].

    PubMed

    van der Hoogte, Arjo Roersch; Pieters, Toine

    2010-01-01

    In this article we explore the historical development of drug advertisements for psychotropic drugs in the leading Dutch medical journal from 1900 to 1940. The advertisements for hypnotics and sedatives, in The Nederlands Tijdschrift voor Geneeskunde (Dutch medical journal) reflected the changes in the vocabulary and image promoted by the pharmaceutical companies. In the first two decades, the advertisements were sober and to the point, and included the trademark, company name, molecular formula and therapeutic properties of the medication. The emphasis was on creating a scientific image of reliable symptom control for the therapeutic drug. In doing so, the ethical drug companies tried (successfully) to distinguish themselves from the producers of patent medicines. Once scientific credibility was established, the form and content of the advertisements changed significantly. In the late 1920s and 1930s drug companies embraced modern advertising techniques, developing a figurative language to address the changing beliefs and practices of Dutch physicians. Instead of promoting therapeutic drugs as safe and scientific, the emphasis was on their effectiveness in comparison to similar drugs. In the process, scientific information was reduced to an indispensable standardized minimum, whereby therapeutic drugs were advertised according to the latest pharmacological taxonomy rather than molecular formulas. The image-making of 'ethical marketing' began during the interwar years when marketers applied modern advertising techniques and infotainment strategies. The scanty black and white informational bulletins transitioned into colourful advertisements. The pharmaceutical companies employed the same medical language as used by physicians, so that one word or image in an advertisement would suffice for the physician to recognize a drug and its therapeutic properties. These developments show the changing relationship between the modern ethical pharmaceutical industry and Dutch

  16. [The rise of remedial gymnastics [heilgymnastiek].

    PubMed

    Terlouw, T

    1996-01-01

    In this article the introduction and further development of remedial gymnastics in the Netherlands from 1840 until about 1900 is described. In the second half of the 19th century there was an increasing interest for the application of remedial gymnastics as a form of conservative medical treatment. Contrary to what one would expect, it were not physicians but mostly physical education teachers who dedicated themselves to this kind of treatment. The activities of these so-called 'heilgymnasten' gradually gained recognition from the public and the physicians. The lack of a proper training school, research facilities and a forum for exchanging experiences forced the 'heilgymnasten' to raise the level of their skills and knowledge by themselves. During the eighties, a period in which the process of differentiation and specialization in the field of medicin increased, conflicts between members of the medical profession and 'heilgymnastern' occurred more frequently. Some of the latter decided to form an organization that would look after their interests and would enable them to increase the professional level of the 'heilgymnasten'. On September 1st 1889 the 'Society for practising remedial gymnastics in the Netherlands' [Genootschap ter beoefening van de Heilgymnastiek in Nederland] was founded. The main aims of its members were to establish a state exam, a public training school as well as to ensure proper legislation for this new profession. The founding of the Socieity lifted the controversy between physicians and 'heilgymnasten' from the level of a dispute between individuals to that of a battle over the domain between professional organizations. What was at stake was the autonomy in the field of remedial gymnastics. This confrontation lasted until the Second World War. In 1942 the Dutch 'heilgymnasten' got the legal status for their profession that they had wanted so desperately.

  17. Installation Restoration Program. Preliminary Assessment: 273rd Engineering Installation Squadron, Nederland Air National Guard Station, Texas Air National Guard, Nederland, Texas

    DTIC Science & Technology

    1990-12-01

    ABSTRACT Unclassified NSN 7540-01-280-5500 Standard For- .98 (Rev 2-89) PT’re~~ bi %~*. . f9~ i i INSTALLATION RESTORATION PROGRAM PRELIMINARY ASSESSMENT...state records on endangered species, threatened species, and critical habitats; documents from local government offices; and numerous standard reference...migration. If applicable, a public health evaluation is performed to analyze the collected data. Field tests, which may necessitate the installation

  18. Zertifikat Niederlaendisch: Examen en getuigschrift Nederlands als vreemde taal (Certificate in Dutch)

    ERIC Educational Resources Information Center

    Beersmans, Frans; Sudhoelter, Juergen

    1976-01-01

    An interim report on preparations for designing an examination in Dutch. The "unit-credit system" proposed by the Council of Europe is being used. The Dutch certificate will be comparable to the certificates given by the British Council and by the People's Universities. Sample portions are given. (Text is in German.) (IFS/WGA)

  19. 78 FR 26056 - Waterway Suitability Assessment for Expansion of Liquefied Gas Terminals; Nederland, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-03

    ... Management Facility (M-30), U.S. Department of Transportation, West Building Ground Floor, Room W12-140, 1200... Facility in Room W12-140 on the ground floor of the Department of Transportation West Building, 1200 New... Liquefied Natural Gas (LNG) or Liquefied Hazardous Gas (LHG), where the construction, expansion, or...

  20. [New policy regarding the number of authors included with articles in the Nederlands Tijdschrift voor Geneeskunde (Dutch Journal of Medicine)].

    PubMed

    2006-03-18

    The editors of this journal have decided that the number of authors of original articles and guidelines may in the future exceed the current limit of six. For other articles, e.g. clinical lessons, case reports and review articles, the limit remains. Contributions to the series 'Diagnostic image' will have a maximum of two authors. For a number of years now, authors have been asked to provide specific information as to the nature of their contribution to the article that carries their name. This enables the editors and the reviewers to assess whether the criteria for authorship have been met. Information on authors' contributions will not be printed alongside the articles but will be kept available to readers for three months after the article has appeared.

  1. Zuivere en toegepaste wetenschap in de tropen : biologisch onderzoek aan particuliere proefstations in Nederlands-Indië 1870-1940

    NASA Astrophysics Data System (ADS)

    van der Schoor, W. J.

    2012-04-01

    Most experiment stations originated from the cooperation between entrepreneurs and the government. From the 1890s onwards, the government, together with the well organised colonial entrepreneurs, established research departments for several plantation crops at the Botanical Gardens at Buitenzorg (now Bogor), that eventually became independent experiment stations in the first decades of the twentieth century. By the 1920s, the ‘proefstationswezen’ (experiment station system) numbered some fifteen private experiment stations or sub-stations. After the war, the private experiment stations together with the government experiment stations at Buitenzorg were to provide the backbone of Indonesian agricultural science. Dutch biologists in particular, made a striking plea for pursuing the natural sciences in the tropical colonies. First, they pointed out the scientific importance of the tropics. Secondly, they stressed the role of the natural sciences, in particular biology, as a natural ally of colonial agriculture. Pure science was seen as a leading force for technical and social progress. The third motive was the cultural value of science for the Netherlands and its colonies. The cultivation of science in the colonies gave international prestige and strengthened self-confidence in the imperial struggle around 1900. Science had a civilising effect; scientific research, however, was to remain in the hands of western, colonial scientists. From the 1880s and 1890s onward, the experiment stations in the Indies were characterised by their strategic aims and scientific orientation. Up to 1910, the ‘academic’ views of biologists like Treub and Went concerning science and practice were predominant, and research was considered to be the central aim. From 1910 onwards, advice became more central and special extension services were established at the experiment stations. Due to diverging views of science, tasks and aims became a battlefield for discussions in the next decades. In the background of these debates were the rise of Wageningen Agricultural College, the rise and institutionalisation of applied agricultural sciences and the increasing competition between Wageningen and university trained scientist. Genetics and breeding in particular were at the core of the research programmes. The practical aim of the breeding work, however, did not leave too much opportunity for more fundamental investigations. The impetus for pure research came from individual researchers. In tobacco and sugar cane breeding, new scientific theories provided inspiration, but to a large extent the practical breeding work built on nineteenth-century breeding techniques. In many respects, plant breeding and university genetics became separate disciplines. Circa one in six Dutch biologist worked for at least some time in the colony. The colonial experiment stations instilled a practical and pragmatic attitude to Dutch science into quite a number of biologists. Besides, the experiment stations system provided Dutch biologists with an extensive network and international contacts with fellow scientists, entrepreneurs and captains of industry. The scientific nationalism of Treub and Went, the bloom of the experiment stations and the ambitions of the Indies colonial elite did not result in the establishment of an independent, ‘Indische’ scientific community. Essentially, the Dutch East Indies were an exploitation province of Dutch science

  2. Restrained Policy and Careless Execution: Allied Strategic Bombing on the Netherlands in the Second World War

    DTIC Science & Technology

    2011-05-19

    Nederland 1919- 1945. (Series). Den Haag, The Netherlands: Instituut voor Nederlandse Geschiedenis, 2004. AAF Historical Division, United States Airforce...food and money to the crew of a downed British Wellington. Source: A. Korthals Altes, Luchtgevaar: Luchtaanvallen op Nederland , 1940- 1945...of the Liberation of Europe (New York: Free Press, 2008). 6Chris van der Heijden, Grijs Verleden: Nederland en de Tweede Wereldoorlog (Amsterdam

  3. 75 FR 64675 - Approval and Promulgation of Implementation Plans and Designation of Areas for Air Quality...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-10-20

    ... Orange; Mayor, City of Lumberton; Mayor, City of Nederland; County Judge, Orange County; Jefferson County..., Nederland; Plant Manager, Solvay Solexis, Inc., Orange; Huntsman Petrochemical LLC, Port Neches; Sabine-Neches Navigation District, Nederland; and the Greater El Paso Chamber of Commerce. EPA also...

  4. [110th year Nederlands Tijdschrift voor Tandheelkunde. 2. Root canal treatment, intra-canal disinfectants and bacterial culture: past and present].

    PubMed

    Moorer, W R; Wesselink, P R

    2003-05-01

    Fifty years ago the Dutch Journal of Dentistry published methods and opinions concerning root canal treatment. Qualitative bacterial culture, inclusion of aggressive disinfectants, as well as antibiotics and widening of the apical constriction were carried out. Nowadays, because of several reasons, these are not clinical practice anymore. Controversy over the clinical consequences of bacterial presence in tubules and in the peri-apical area prevailed in the past and seem to be prevalent once again.

  5. Sea Basing Logistiek

    DTIC Science & Technology

    2007-11-01

    iets wat nu voor zware goederen niet mogeljk is met de middelen binnen de Nederlandse krijgsmachit. Nederland heeft bijvoorbeeld (nog) geen specifieke...weer gevechtsklaar zijn. Nederlandse troepen voeren de reconstitute fase in het algemeen uit in Nederland . [Kang&Gue] A special concern in sea based...besluit Nederland zelf in te grijpen. De Nederlandse vredesmissie bevindt zich nabij de kust. maar ver van de grens met buurlanden. De operatie kan niet

  6. Reducing Alcohol Harm. International Benchmark

    DTIC Science & Technology

    2008-01-01

    Gezondheidszorg [GGZ] Nederland ), which together represent most of the institutions involved in addiction care and counselling, the majority of which are...Jaarverslag GGZ Nederland 2006”, (2006), http://741620.websites.xs4all.nl/Jaarverslag_GGZ_Nederland.pdf (accessed April 2008). RAND Europe 31...2007. 92 E.W. de Bekker-Grob, J.J. Polder, K. Witte, J.P. Mackenbach and W.J. Meerding, “Kosten van preventie in Nederland 2003: Zorg voor euro’s

  7. Flood-Side Wave Erosion of Earthen Levees: Present State of Knowledge and Assessment of Armoring Necessity

    DTIC Science & Technology

    2010-08-01

    Advisory Committee for Flood Defence in the Netherlands. TAW. 2004. De veiligheid van de primaire waterkeringen in Nederland . Voorschrift Toetsen op...Netherlands. TAW VTV. 2004. De veiligheid van de primaire waterkeringen in Nederland . Voorschrift Toetsen op Veiligheid voor de tweede toetsronde 2001

  8. Realization of a Visual Surveillance System Used by Manoeuvres at Night, on the Combat Range ISK de Harskamp"

    DTIC Science & Technology

    2007-11-02

    Laboratorium TNO Prins Maurits Laboratorium Nederlandse Organisatie voor toegepast- natuurwetenschappetijk onderzoek TNO Management uittreksel TNO...ISK bij duisternis. Siemens Nederland BV. Siemens (1997). Gebruikshandleiding CCTV voor het project Waarneming gevechtsbaan ISK bij duisternis...Siemens Nederland BV. Stroethof, J.W. (1994). Studie beveiliging Harskamp (Rapport FEL 94-A115). ’s-Gravenhage: TNO Fysisch en Elektronisch Laboratorium

  9. CMMI Roadmaps

    DTIC Science & Technology

    2008-11-01

    van de Vorst—Ordina J. de Vries—LogicaCMG Nederland J.M. Wijsman—Sogeti J.H.G. Willemsen— Nederlandse Spoorwegen A.P.J.J. Zopfi—KZA Additional...Attendees of the SPIder Workshop D. Bierhuizen—Medis Medical Imaging Systems L. Braafhart—LogicaCMG Nederland H.J.J. Cannegieter—SYSQA W. den...Dekker—LogicaCMG Nederland L. Delmelk—LogicaCMG België A.J. Donderman—Transfer Solutions G.H.M. Friedhoff—SYSQA L.L. van der Giessen—ABN AMRO M

  10. 77 FR 55864 - Sunshine Act Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-11

    ... Containership MSC Nederland, Houston Ship Channel, Upper Galveston Bay, Texas, October 29, 2011. NEWS MEDIA... a live or archived webcast by accessing a link under ``News & Events'' on the NTSB home page at...

  11. 75 FR 34173 - Notice of Determinations Regarding Eligibility To Apply for Worker Adjustment Assistance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-16

    ... 14, 2010 TA-W-73,957: Cessna Aircraft, Columbus Facility, Fabrication and Assembly, Leased Workers...., Butler, PA TA-W-72,697: Lucite International, Inc., Nederland, TX TA-W-73,080: ATK Launch Systems,...

  12. Job Oriented Training: Onderwijskundige Grondslag en Onderbouwing (Job Oriented Training: Foundation and Empirical Support)

    DTIC Science & Technology

    2008-07-01

    TNO Rapport SAl i , Nederlandse Organisatie vo? toegepasl-natuuweterschappeik onclerzoekr/ Netherlands OrganisationTNO Defensie en...alle eerdere visies op leren is ook het sociaal constructivisme onderwerp van stevig debat. Dit debat is in Nederland in de laatste jaren in alle...deze stroming vallen in Nederland onder de noemer het nieuiwe leren. Het nieuwe leren kent zeer positieve voorbeelden, mnaar ook vele voorbeelden waarbij

  13. European Security: Chances for a European Defense Entity

    DTIC Science & Technology

    1991-04-12

    terms of a (military) balance between Russia , Germany, Great Britain, France and Austria-Hungary. The balance was not stable as diplomacy...defensie tegen een nieuwe achtergrond," Nederlands instituut voor internationale betrekkingen ’Clingendael,’ November 1990, p. 6, ("The image of threat...implications for Europe as a consequence of the Gulf crisis; o How to cooperate with the East European Nations. See Jan Gerritsen, " Nederland

  14. The Strategic Petroleum Reserve.

    DTIC Science & Technology

    1994-05-01

    untried, option for filling the SPR. Surplus government stocks could be used to trade for oil with countries such as Russia . This would save storage...inch diameter, 25 mile long pipeline from the Sun Terminal in Nederland , Texas. The site was designed to fill at a sustained rate of 280,000 bbl of... Nederland . Texas. Stocks can also be drawn down through a 36 inch diameter, 12 mile pipeline connected to the Texas 22-inch common carrier pipeline which is

  15. Documenting Living Monuments in Indonesia: Methodology for Sustainable Utility

    NASA Astrophysics Data System (ADS)

    Suryaningsih, F.; Purwestri, N.

    2013-07-01

    The systematic documentation of cultural heritage in Indonesia has been developed after the establishment of Bataviaasch Genootschap van Kunsten en Wetenschappen (1778) and De Oudheidkundige Dienst (1913) by the Netherlands Indies government. After Indonesian independent, the tasks of cultural heritage documentation take over by The Ministry of Culture (now become The Ministry of Education of Culture) with focus on the ancient and classical heritage, so called dead monument. The needed of comprehensive documentation data regarding cultural heritage become significant issues since the government and private sector pay attention to the preservation of heritage building in the urban site, so called living monument. The archives of original drawing plan many times do not fit with the existing condition, while the conservation plan demands a document such as built drawing plan to work on. The technology, methodology and system to provide such comprehensive document of heritage building and site become important, to produce good conservation plan and heritage building regular maintenance. It means the products will have a sustainable and various utility values. Since 1994, Documentation Centre for Architecture - Indonesia (PDA), has established to meet the needs of a comprehensive data of heritage building (living monuments), to utilized as basic document for conservation planning. Not only provide document of the digital drawing such site plan, plan, elevation, section and details of architecture elements, but also document of historic research, material analysis and completed with diagnosis and mapping of building damages. This manuscript is about PDA field experience, working in this subject issue

  16. "A bare outpost of learned European culture on the edge of the jungles of Java": Johan Maurits Mohr (1716-1775) and the emergence of instrumental and institutional science in Dutch Colonial Indonesia

    NASA Astrophysics Data System (ADS)

    Zuidervaart, Huib J.; van Gent, Robert H.

    2004-03-01

    The transits of Venus in 1761 and 1769 appear to mark the starting point of instrumental science in the Dutch East Indies (now Indonesia). This essay examines the conditions that triggered and constituted instrumental and institutional science on Indonesian soil in the late eighteenth century. In 1765 the Reverend J. M. Mohr, whose wife had received a large inheritance, undertook to build a fully equipped private observatory in Batavia (now Jakarta). There he made several major astronomical and meteorological observations. Mohr's initiative inspired other Europeans living on Java around 1770 to start a scientific movement. Because of the lack of governmental and other support, it was not until 1778 that this offspring of the Dutch-Indonesian Enlightenment became a reality. The Bataviaasch Genootschap van Kunsten en Wetenschappen tried from the beginning to put into effect the program Mohr had outlined. The members even bought his instruments from his widow, intending to continue his measurements. For a number of reasons, however, this instrumental program was more than the society could support. Around 1790 instrumental science in the former Dutch East Indies came to a standstill, not to be resumed for several decades.

  17. "A bare outpost of learned European culture on the edge of the jungles of Java": Johan Maurits Mohr (1716-1775) and the emergence of instrumental and institutional science in Dutch colonial Indonesia.

    PubMed

    Zuidervaart, Huib J; Van Gent, Rob H

    2004-03-01

    The transits of Venus in 1761 and 1769 appear to mark the starting point of instrumental science in the Dutch East Indies (now Indonesia). This essay examines the conditions that triggered and constituted instrumental and institutional science on Indonesian soil in the late eighteenth century. In 1765 the Reverend J. M. Mohr, whose wife had received a large inheritance, undertook to build a fully equipped private observatory in Batavia (now Jakarta). There he made several major astronomical and meteorological observations. Mohr's initiative inspired other Europeans living on Java around 1770 to start a scientific movement. Because of the lack of governmental and other support, it was not until 1778 that this offspring of the Dutch-Indonesian Enlightenment became a reality. The Bataviaasch Genootschap van Kunsten en Wetenschappen tried from the beginning to put into effect the program Mohr had outlined. The members even bought his instruments from his widow, intending to continue his measurements. For a number of reasons, however, this instrumental program was more than the society could support. Around 1790 instrumental science in the former Dutch East Indies came to a standstill, not to be resumed for several decades.

  18. Relevance of Riverine Capability for Today’s Portuguese Navy

    DTIC Science & Technology

    2009-01-01

    Republica I Serie B nO16, January 20, 2003. Portuguese Government. Programa do XVII Governo Constitucional . [Program of the 17th Portuguese...Guiana Jamaica Martinique Mexico Montserrat Nederland’s Antilles Nicaragua Panama Peru Porto Rico Sl. Kitts Sl. Lucia Sl. Vicente Trinidad and Tobago

  19. Processing and Microfiltration of Mosquitoes for Malaria Antigen Detection in a Rapid Dot Immunobinding Assay

    DTIC Science & Technology

    1990-08-01

    then mixed and homogenized to- as Leishmania spp. in sand flies and Borrelia spp. in ticks. gether as described above with 0.01% SDS. A total of 100 1...through the mem- tweede patient met malaria tropica op natuurlijke wijzeverkregen in Nederland. Ned. Tijdschr. Geneeskd. 125:375-377.branes. As positive

  20. OpenER, a Dutch Initiative in Open Educational Resources

    ERIC Educational Resources Information Center

    Schuwer, Robert; Mulder, Fred

    2009-01-01

    Over the period 2006-2008, the Dutch Open Universiteit Nederland conducted an experiment in which Open Educational Resources (OER) were offered in an effort to bridge the gap between informal and formal learning and to establish a new style of entry portal to higher education with no barriers at all. OpenER received considerable attention both in…

  1. Herontwerp Ballistisch vest voor Vrouwen: Fase 1 (Redesign Ballistic Vest for Women: Phase 1)

    DTIC Science & Technology

    2008-09-01

    TNO Rapport 20081027309 Nederlandse Organisatie soor toegepast-natuurwetenschiappeljk TNO efe sie n V ilig idonlderzoek/ Netherlands Organisation...houden van bet plaatoppervlak, het lichaam onbeschermd blij ft. Nederland is niet bet enige land dat overweegt om de vorm van de ballistische platen aan te

  2. Operational Ocean Modelling with the Harvard Ocean Prediction System

    DTIC Science & Technology

    2008-11-01

    TNO Defence, Security and Safety Nederlandse Organisatie voor toegepast-natuurwetenschappelijk onderzoek/ Netherlands Organisation for Applied...een goede blik in de wereld van de operationele oceanografie. Zonder in Nederland alle benodigde kennis en infrastructuur zelf op te bouwen, heeft...dit project handvatten geleverd voor verdere uitbouw van toepassing van operationele modellen binnen de Nederlandse krijgsmacht. Voor snelle

  3. Dutch Anthropometry for Vehicle Design and Evaluation

    DTIC Science & Technology

    2008-10-01

    Nederlands antropometrisch bestand (NedScan) en van lichaamsafmetingen van goedgekeurde K.L rekruten. De grenswaarden omvatten 95% van dat Nederlandse ...TNO Defence, Security and Safety Nederlandse Organisatie voor toegepast-natuurwetenschappelijk onderzoek / Netherlands Organisation for Applied...parties E 2008 TNO 20090213220 fdl-of-d^ 2/17 Nederlandse antropometrie voor voertuigontwerp en -evaluaties Probleemstelling Thans staan we aan de

  4. Implementation of an Evidence-Based Guideline for the Referral of Adults Who Are Visually Impaired in the Netherlands: Potential Barriers

    ERIC Educational Resources Information Center

    Cruysberg, Juliette K.; van Rens, Ger H. M. B.

    2007-01-01

    This article reports on a study on the implementation of an evidence-based guideline for the referral for rehabilitation of adults who are visually impaired in the Netherlands. The purpose of the study was to find out if there are potential barriers to the implementation of the Nederlands Oogheelkundig Gezelschap (NOG) (2004) evidence-based…

  5. Optimalisatie Draagsysteem (Optimization of the Load Carriage System)

    DTIC Science & Technology

    2008-06-01

    Nederlandse Organisat~e voor toegepast-natuurwetenschappeljk TNO efen ie n Veligoiderz/ Netherands Organisation Kampweg 5 Postbus 23 3769 ZG...load carriage system), TNO-rapport, TNO-DV 2007 A25 1, TNO Defensie en Veiligheid, Soesterberg, Nederland . TNO-rapport I TNO-DV 2008 A230 27 /27 9

  6. Early T-Precursor Thymocytes as Potential Target Cells for HIV infection

    DTIC Science & Technology

    1994-07-22

    ABELEV, Laboratory of Immunochemistry. Cancer Research Centre, Kashirskoye Shosse 24, 115 478 Moscow, Russia . Fax: (7-095) 2302450. R. CALLARD...School of Medicine, Los Angeles, CA 90024, USA. Fax: (1-310) 206-3865. C.J.M. MELiEF, 11et Nederlands Kankerinstituut, Plesmanlaan 121, 1066 CX Amsterdam

  7. Latest Calibration of GLONASS P-Code Time Receivers

    DTIC Science & Technology

    2004-12-01

    observed. GLONASS GPS operator Military Space Forces ( Russia ) Department of Defense (USA) nominal number of satellites 24* 24 orbit altitude 19 100...Royal Observatory of Belgium (ORB, Brussel), and the Nederland Meetinstituut, Van Swinden Laboratory (NMi-VSL, Delft). Receiver No. 0017 (BIPM A) was

  8. Wind in the Willows--Theatre Activity Packet.

    ERIC Educational Resources Information Center

    New York City Board of Education, Brooklyn, NY. Div. of Curriculum and Instruction.

    Part of the New York City Board of Education's Early Stages program, and intended for elementary and secondary school teachers who wish to include a unit on theater in their classes, this guide offers suggestions for lessons and activities to accompany viewing a performance of "Wind in the Willows" at the Nederlander Theater. Part one of…

  9. [In Process Citation].

    PubMed

    Brand, H S

    2014-12-01

    Wetenschappelijk onderzoek, zoals elke maand beschreven in het Nederlands Tijdschrift voor Tandheelkunde, begint met een idee. Om het idee te kunnen onderzoeken is vervolgens geld nodig. Hierbij gaat het meestal om grote bedragen. Zo kost een promotieonderzoek van 4 jaar een paar ton aan salariskosten en materialen.

  10. Communicating Astronomy with a Mass Audience — BBC's Stargazing Live goes Dutch

    NASA Astrophysics Data System (ADS)

    Baan, M.

    2015-06-01

    Following on from the hugely successful airing of Heel Nederland Kijkt Sterren — a Dutch stargazing event modelled on the BBC's programme Stargazing Live — this article explores some of the issues involved in communicating astronomy directly to a mass audience. This includes the production process, co-sponsorship, content, the reach and lessons learned.

  11. 77 FR 25728 - Accreditation and Approval of SGS North America, Inc., as a Commercial Gauger and Laboratory

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-01

    ... SECURITY U.S. Customs and Border Protection Accreditation and Approval of SGS North America, Inc., as a.... ACTION: Notice of accreditation and approval of SGS North America, Inc., as a commercial gauger and... America, Inc., 2310 Highway 69 North, Nederland, TX 77627, has been approved to gauge and accredited...

  12. CONFERENCE NOTE: International Workshop on Radiation Thermometry Noordwijkerhout, the Netherlands, 24 25 June 1993

    NASA Astrophysics Data System (ADS)

    1993-01-01

    Radiation thermometry is applied in the measurement of temperature where direct contact with the object is impossible, such as in the case of very high temperatures or moving bodies. Important industrial applications are metal, glass, ceramics and plastics and, latterly, semiconductor technology. Recent developments, such as multi-wavelength pyrometry, have motivated the Nederlands Meetinstituut and two Russian institutes, Energotechnica and Symco Association, to organize this workshop. Specialists from Russia, the USA, the UK, Germany and the Netherlands will present state-of-the-art practical applications in radiation thermometry. The workshop will be held on 24 and 25 June 1993 in the "Leeuwenhorst" Congress Centre, Noordwijkerhout, the Netherlands. Information on the technical contents of the programme can be obtained from Dr P Bloembergen, Tel. +31(15) 691 660. Registration For further details please contact: The Training and Consultancy Department, Nederlands Meetinstituut, PO Box 654, 2600 AR Delft, the Netherlands Tel. +31 (15) 691 567.

  13. [Misleading advertisement on Opatanol].

    PubMed

    Timmermans, A E

    2006-07-01

    In an advertisement in this journal, Alcon Nederland BV has recommended Opatanol (olopatadin) as the 'first choice medication/NHG practice guideline for Red eye/Allergic conjunctivitis'. However, the practice guideline of the Dutch College of General Practitioners (NHG) mentions the following 3 antihistaminica as first choice for the treatment of red eye/allergic conjunctivitis: azelastin, levocabastin or olopatadin. Therefore, it is concluded that the Alcon advertisement is misleading.

  14. Bibliography of Technical Publications, Papers, and List of Patents, October 1983 - September 1984

    DTIC Science & Technology

    1984-11-01

    TR-84/013, February 1984 (AD A139 885). 8. SHERMAN, D. E., S. REI, J. WALL, and B. BELL. Evaluation of T Rations and the Mobile Food Service Unit at...HERTWECK, G. Mobile Food Service Unit and Tray Pack heating. Young Presidents of America Association, Ft. Devens, MA, April 26 1984. 45. KIM, H. J...rations on troop effectiveness. Nederlands Militair Geneeskundig Tijdschrift, 37: 97-100 (1984). 12 Io" SCIENCE AND ADVANCED TECHNOLOGYI LABORATORY

  15. 76 FR 20363 - Accreditation and Approval of Camin Cargo Control, Inc., as a Commercial Gauger and Laboratory

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-12

    ...Notice is hereby given that, pursuant to 19 CFR 151.12 and 19 CFR 151.13, Camin Cargo Control, Inc., 1550 Industrial Park Drive, Nederland, TX 77627, has been approved to gauge and accredited to test petroleum and petroleum products for customs purposes, in accordance with the provisions of 19 CFR 151.12 and 19 CFR 151.13. Anyone wishing to employ this entity to conduct laboratory analyses and......

  16. SHORT COMMUNICATION: Comparisons of the Josephson Voltage Standard of the BIPM with those of the OFM and the NMi

    NASA Astrophysics Data System (ADS)

    Reymanr, D.; Feller, U.; de la Court, P.; Witt, T. J.

    1994-01-01

    Comparisons of the Josephson array voltage standard of the Bureau International des Poids et Mesures (BIPM) were made with those of the Swiss Federal Office of Metrology (OFM), Wabern, Switzerland, in November 1992 and of the Nederlands Meetinstituut-Van Swinden Laboratorium (NMi), Delft, the Netherlands, in March 1993. Direct and indirect comparison results indicate agreement between the voltage standards to within 1 nV.

  17. [Administration of intravenous sedation with midazolam by dentists is unsafe].

    PubMed

    Broers, D L M; Plat, J; de Jongh, A; Zuidgeest, T G M; Blom, H C C M; Kraaijenhagen, A E; Pieterse, C M; Bildt, M M

    2015-03-01

    In the December issue of the Nederlands Tijdschrift voor Tandheelkunde (Dutch Journal of Dentistry) in 2014, an article was devoted to the use of light sedation with midazolam by dentists. A number of dentists who are active in the area of Special Dentistry (anxiety management, care of the disabled) and a anesthesiologist offer a response to the article and argue that the administration of intravenous sedation with midazolam by dentists is unsafe.

  18. Report of the Inland Waterway Transport (IWT) Mission, 5 February-20 April 1985. Main Report

    DTIC Science & Technology

    1985-06-01

    ESCAP region will . be fruitful . The capabilities within the country are often not optimally used for the reasons indicated in section 3.3.1, on water ...ELEMENT. PROJECT, TASK Institute for Water Resources (USACE) AREAA WORK UNIT NUMBERS Delft Hydraulic Laboratory (the Netherlands) Maritiem Research...Instituut Nederland 1. CONTROLLING OFFICE NAME AND ADDRESS 12. REPORT DATE Water Resources Support Center June 1985 Institute for Water Resources 13

  19. Iraq: Oil-for-Food Program

    DTIC Science & Technology

    2000-11-29

    Nederland BV, an energy services firm working under contract to the oil-for-food program. Iraq negotiates with supplier firms for goods and services... Russia and France that, beginning in Phase Nine of the oil-for-food program (commencing December 5, 2000), the amount of revenue that will be deducted...to ensure it is not carrying contraband goods. France, Russia , and other governments, although not opposed in principle to inspecting cargo bound for

  20. 2006 JSOU/NDIA SO/LIC Chapter Essays

    DTIC Science & Technology

    2006-06-01

    1942-1946 (Houten: de Haan, 1987). Translation (Dutch publication) is Mission Sumatra, The Korps Insulinde, 1942-1946. 6. Koninklijk Nederlands ...was not willing to modify his political ends, as he needed funds in preparation for his planned invasion of Russia . Instead of changing to match...and all his troops, to enable him to attack Russia and was, therefore, neither willing to change his guid- ance nor provide additional forces. The

  1. A General Formula for Noncohesive Suspended Sediment Transport

    DTIC Science & Technology

    2008-05-01

    66) River 22 0.18–0.33 20 0.2–0.6 0.05–0.15 Voogt, Van Rijn, and Van den Berg (1991) Krammer beach, The Nederlands (April 1987) Tidal channel 60 0.22...Department Technical Report 55JRBZ. BATTJES, J., 1983. Surf zone turbulence. In: Proceedings of the 20th IAHR Congress (Moscow, Russia ), pp. 137–140

  2. Aerodynamics of Rotorcraft (L’Aerodynamique des Aeronefs a Voilure Tournante)

    DTIC Science & Technology

    1990-11-01

    drawn bow through the bowstring wound around a central shaft. It is reported that Mikhail Lomonosov of Russia also flew a model at about the same time... Russia . His name was Igor Sikorsky. He made one unsuccessful attempt in 1909 at the age of 20, and built a second machine one year later (Figure 19...Directorate and NASA Ames have performed in the Duits Nederlands Wind tunnel (DNW) an impressive series oftests with a pressure gage instrumented model

  3. Operating in the Human Domain Lessons of a Decade of War for the Dutch Army

    DTIC Science & Technology

    2014-06-13

    predict outcomes; in which defeat to have any meaning must be inflicted above all in the minds of the defeated. ― Lieutenant General Paul K. Van Riper ...Plasschaert, Minister of Defense, In Het Belang Van Nederland [in the Interest of the Netherlands] (The Hague, The Netherlands: Ministry of Defense...Colonel N. A. W. Tak, Memorandum Van Voormalige Commandanten Task Force Uruzgan Aan De Commandant Der Strijdkrachten [Memorandum of Former Commanders Task

  4. Genetic diagnostics and genetic counselling in Hypertrophic Cardiomyopathy (HCM)

    PubMed Central

    2010-01-01

    Dutch professional groups involved in drawing up this guideline: cardiologists, paediatric cardiologists, clinical geneticists, clinical molecular geneticists, genetic counsellors, psychosocial workers, associated with or cooperating with the university hospitals’ outpatient clinics for cardiogenetics. Approved by the NVVC, VKGN and NVK (paediatric cardiology section). NVVC - Nederlandse Vereniging voor Cardiologie – Dutch Society for Cardiology; VKGN - Vereniging Klinische Genetica Nederland – the Netherlands Society for Clinical Genetics; NVK - Nederlandse Vereniging Kindergeneeskunde – Dutch Society for Paediatrics. First published in Dutch in June 2009. PMID:20390065

  5. [Treatment of periodontitis in cases of diabetes mellitus is always worthwhile!].

    PubMed

    Loos, B G; Teeuw, W J; Gerdes, V; Abbas, F

    2014-09-01

    In the May edition of The Nederlands Tijdschrift voor Tandheelkunde the editorial commentary was devoted to the question to what extent the treatment of periodontitis in patients with diabetes mellitus is worthwhile. B.G. Loos, W.J. Teeuw, V. Gerdes and F. Abbas offer a response to this commentary and argue that the treatment of periodontitis in patients with diabetes mellitus is always worthwhile.

  6. Evaluation of the Netherlands' International Test Facility for Smart Grids

    SciTech Connect

    Palmintier, Bryan; Pratt, Annabelle

    2015-06-01

    The Netherlands Enterprise Agency (Rijksdienst voor Ondernemend Nederland, or RVO) engaged the U.S. National Renewable Energy Laboratory (NREL) for two primary purposes: to evaluate the International Test Facility for Smart Grids (ITF) sponsored by RVO and to learn best practices for integrated test facilities from NREL's Energy Systems Integration Facility (ESIF). This report covers the ITF evaluation and is largely based on a one-week visit to the Netherlands in November 2014.

  7. [Trends in suicidal behaviour in Dutch general practice, 1983-2013].

    PubMed

    de Beurs, D P; Hooiveld, M; Kerkhof, A J F M; Korevaar, J C; Donker, G A

    2016-01-01

    We investigated trends in suicidal behaviour as reported by Dutch general practices from 1983 to 2013. Also, we analysed the relationship with patient characteristics and with the financial crisis of 2008. Retrospective observational study. We estimated age-adjusted and gender-specific trends in suicides (342) and attempted suicides (1614), as registered in 1983-2013 under ICPC code P77 by 40 Dutch general practices participating in the NIVEL Primary Care Database sentinel station. Secondary outcomes, on the basis of supplementary questions in the GP Information System (Huisartsen Informatie Systeem), were the relationship between suicidal behaviour, earlier treatments and patient characteristics. Also, we analysed separate frequencies for the periods 1983-2007 and 2008-2013. Join-point analyses revealed a significant rise in male suicides from 2008 (b = 0.32, SE = 0.1, p = 0.008), and an increase in male suicide attempts since 2009 (b = 0.19, SE = 0.04, p < 0.001). Female suicidal behaviour showed a steady decrease in 1989-2013: b = -0.03, SE = 0.007, p < 0.0001 for female suicide, b = -0.02, SE = 0.002, p < 0.001 for female attempts. Almost half of the suicidal patients had visited their GP one month before the event. In 31% of these patients, the GP had recognized suicidal behaviour. Since 2008, there was a rise in the male suicide rate while female suicide behaviour has continued to decline. Training in the early recognition of suicide ideation in depressive patients might improve suicide prevention in primary care.

  8. [The gift of pharmacopoeias made by Mésaize to the Society of Pharmacists of Rouen].

    PubMed

    Lafont, Olivier; Vettes, Jules

    2015-12-01

    Pierre-Grégoire Mésaize, a pharmacist of Rouen made an important gift to the Society of pharmacists of Rouen in 1831. 21 Books, mainly foreign pharmacopoeias, constituted this gift. Six were from Germany; five came from United Kingdom, three from Nederland, only two from France, and one from Belgium, one from Switzerland, one from Austria and one from Russia. This diversity of origins was quite informative about the quality of the content of pharmacists' libraries in Rouen at the beginning of the 19th century. Unfortunately these books could not be found nowadays in the Library of the Union of pharmacists of Seine-Maritime.

  9. AmeriFlux US-NR1 Niwot Ridge Forest (LTER NWT1)

    DOE Data Explorer

    Blanken, Peter [University of Colorado

    2016-01-01

    This is the AmeriFlux version of the carbon flux data for the site US-NR1 Niwot Ridge Forest (LTER NWT1). Site Description - The Niwot Ridge AmeriFlux site is located in a subalpine forest ecosystem just below the Continental Divide near Nederland, CO. The site is located at 3050 m elevation, within 600m of the NOAA C1 long-term monitoring station, approximately 8 km east of the Continental Divide. The surrounding subalpine forest is ~97 years old and in a state of aggradation, having recovered from early twentieth century logging (Monson, et al. Global Change Biology (2002), 8 459-478).

  10. Centrifuge for separating helium from natural gas

    SciTech Connect

    Theyse, F.H.; Kelling, F.E.T.

    1980-01-08

    Ultra Centrifuge Nederland N.V.'s improved centrifuge for separating helium from natural gas comprises a hollow cylindrical rotor, designated as a separating drum, within a stationary housing. Natural gas liquids that condense under pressure in the separating drum pass through openings in the drum into the space between the drum and housing. In this space, a series of openings, or throttling restrictors, allows the liquids to expand and return to gas. The gaseous component that does not liquefy in the drum remains separate for drawing off.

  11. Algorithms for radio interference detection and removal

    NASA Astrophysics Data System (ADS)

    Offringa, Anne René

    2012-06-01

    Tijdens dit onderzoek hebben we gekeken naar de invloed van storing door menselijke apparatuur op radioastronomie. Radiosterrenwachten zoals Westerbork kunnen de hemel met een enorme gevoeligheid en resolutie in kaart brengen. Vaak bestaan zulke sterrenwachten uit een aantal grote schotelantennes. Echter, nieuwe technologische ontwikkelingen hebben ervoor gezorgd dat op lage frequenties vele kleine antennes efficiënt gecombineerd kunnen worden tot een grote schoteltelescoop. LOFAR is een nieuwe, deels-Nederlandse supertelescoop die gebruik maakt van dit principe. Deze telescoop bestaat uit tientallen velden gevuld met vele antennetjes, verspreid over Nederland en omringende landen. Het centrum van LOFAR bevindt zich in de buurt van het Drentse dorp Exloo. Radiotelescopen worden meestal in zeer afgelegen gebieden geplaatst, omdat menselijke apparatuur storing veroorzaakt. Het bouwen van een radiotelescoop op afgelegen locaties is echter niet goedkoop. LOFAR is een nieuwe weg ingeslagen en bevat antennevelden op diverse plaatsen in ons druk bevolkte land. Een belangrijke vraag was daardoor of de storing van menselijke apparatuur niet schadelijk zou zijn voor LOFAR-observaties. In dit proefschrift beantwoorden we deze vraag. We hebben volledig geautomatiseerde technieken ontworpen om storing te verwijderen. Met deze nieuwe technieken weten we de storing op zeer accurate wijze te scheiden van het hemelsignaal. We analyseren de gefilterde data en concluderen dat, na toepassing van deze technieken, we in staat zijn om zeer gevoelige hemelkaarten te maken met LOFAR. Daarmee lijkt het dus een goede keuze geweest te zijn om LOFAR in Nederland te bouwen.

  12. Comparison of reading performance tests concerning difficulty of sentences and paragraphs and their reliability.

    PubMed

    Brussee, Tamara; van Nispen, Ruth M A; Klerkx, Edwin M F J; Knol, Dirk L; van Rens, Ger H M B

    2015-05-01

    In research and practice, sentences or paragraphs of reading tests may be randomly chosen to assess reading performance. This means that in addition to test reliability, all sentences or paragraphs should be reliable and equally difficult to read. The sentences and paragraphs of five (un-) standardised Dutch reading tests were investigated in this regard. Tests were performed with 71 normally sighted persons (mean age 55 [18-86] years). All sentences and paragraphs had equal print size. The relative difficulty of sentences and paragraphs from the five Dutch reading tests was tested with linear mixed models (reading speed) and generalised linear models (mistakes). Reading speed in standard words per min ranged from 179 (Radner) to 142 (De Nederlanders). Reading mistakes per 100 characters ranged from 0.25 (Radner) to 0.40 (Colenbrander). On the Colenbrander charts 7/24 sentences were read significantly faster vs 5/24 read slower (sentence reliability 0.56-0.87); International Reading Speed Texts 3/10 vs 3/10 [0.94-0.97]; Laboratory of Experimental Ophthalmology 14/55 vs 15/55 [0.64-0.92]; De Nederlanders 2/6 vs 3/6 [0.83-0.94]; Radner 4/24 vs 3/24 [0.73-0.87]. Agreement between tests differed from 1 to 36 standard words per minute and 0.01 to 0.14 mistakes per 100 characters. The Radner, with the highest number of equally difficult sentences, is appropriate to measure reading acuity as well as reading speed in a heterogeneous population; the International Reading Speed Texts, with the highest paragraph reliability, provides long paragraphs to measure reading speed. The Colenbrander and Laboratory of Experimental Ophthalmology are suitable for daily practice; however, for research or inspection purposes, reliable sentences must be chosen. Although the clinical relevance of the differences between the tests is debatable, use of the De Nederlanders as a reading test remains questionable. © 2015 The Authors Ophthalmic & Physiological Optics © 2015 The College of

  13. Comparison of 2 Dosages of Intraarticular Triamcinolone for the Treatment of Knee Arthritis: Results of a 12-week Randomized Controlled Clinical Trial.

    PubMed

    Popma, Jan Willem; Snel, Frank W; Haagsma, Cees J; Brummelhuis-Visser, Petra; Oldenhof, Hans G J; van der Palen, Job; van de Laar, Mart A F J

    2015-10-01

    To determine whether a double dose of intraarticular triamcinolone acetonide is more effective for knee arthritis than a 40-mg dose. In this 12-week randomized controlled clinical trial, 40 mg and 80 mg of intraarticular triamcinolone acetonide were compared in patients with knee arthritis. Evaluated variables included a Likert burden scale, visual analog scale pain scale, degree of arthritis activity, presence of swelling, and presence of functional limitation. Ninety-seven patients were randomized. No significant differences were observed between the groups regarding any outcomes. An 80-mg dose of triamcinolone acetonide had no additional benefit compared with 40 mg as treatment for knee arthritis. Nederlands Trial Register; trial registration number: NTR2298.

  14. The hovercraft environment.

    PubMed

    Lovesey, E J

    1970-06-01

    In just over a decade the hovercraft has progressed from first prototype to a successful commercial form of transport which also has the ability to penetrate many environments hitherto virtually inaccessible to manned vehicles. Comparison with rival short range vehicles such as the helicopter and hydrofoil show that the hovercraft has become one of the most versatile forms of transport available. This versatility and ability to operate in unusual or extreme environments has been accompanied by the problems of control and of protection of the occupants of the hovercraft from the hazards associated with these environments. Several of these problems are discussed, together with their possible solutions. This article is based on a paper given to the Nederlands Vereniging Voor Ergonomie/Ergonomics Research Society joint conference at Noordwijk in Holland, 11-13 June, 1969.

  15. TOD characterization of the Gatekeeper electro-optical security system

    NASA Astrophysics Data System (ADS)

    Gosselink, Guido; Anbeek, Hugo; Bijl, Piet; Hogervorst, Maarten A.

    2013-06-01

    The Triangle Orientation Discrimination (TOD) test method was applied to characterize thermal and visual range performance of the Gatekeeper Electro Optical Security System. Gatekeeper developed by Thales Nederland BV, is currently in use with the Royal Netherlands Navy. The system houses uncooled infrared and colour TV cameras providing up to 360° view in azimuth. The images displayed to the operator are automatically optimized based on the scene intensity distribution. Because of this built-in scene-based optimization, proper measurement of the system requires careful surround illumination of the TOD setup over a large part of the camera Field Of View. The tests provided very accurate threshold estimates with relatively small observer differences. The resulting TOD curves that characterize the sensor system in terms of acuity and contrast sensitivity can be used as input to a Target Acquisition model to predict range performance for operational scenarios.

  16. Development of advanced concepts for DIR-MCFC cogeneration applications in the European Market

    SciTech Connect

    Kortbeek, P.J.; Ottervanger, R.G.; Dicks, A.L.

    1996-12-31

    Early 1996 a three year (1996 - 1998) joint European project was launched under the name {open_quote}Advanced DIR-MCFC Development{close_quote}, aiming at the development of Direct Internal Reforming (DIR) Molten Carbonate Fuel Cell (MCFC) systems for cogeneration applications for the European market. In this project participate: Brandstofcel Nederland BV (BCN), British Gas pic (BG), Gaz de France (GDF), Netherlands Energy Research foundation (ECN), Stork, Royal Schelde and Sydkraft AB. The European Fuel Cell User Group (EFCUG) supports the project as an advisory board. Whereas the US and Japanese programmes are aimed at large-scale demonstrations of the MCFC technology, this project focusses on the development of concepts and technology, required for MCFC systems that will be competative on the cogeneration market. The project partners provide the essential expertise: from end-user, system engineering, stack development up to fundamental material research.

  17. ITS-90 Scale Realization on the New Radiation Thermometer Calibration Facility at NMi VSL

    NASA Astrophysics Data System (ADS)

    Dekker, P. R.; van der Ham, E. W. M.

    2008-06-01

    In the first half of 2005, Nederlands Meetinstituut Van Swinden Laboratorium B.V. (NMi VSL) redesigned their facilities for radiation thermometry in a new laboratory building and an opportunity arose to implement new measurement methods. The new facility is used for ITS-90 realization and dissemination in the temperature range from - 50 °C to 3,000 °C. A study was performed to compare a silver-point realization with a fixed-point blackbody radiator (FP-BBR) to a sodium heat-pipe blackbody radiator (HP-BBR) traceable via a HTSPRT to a contact thermometry silver point. It was found that the fixed-point realization transfer to the sodium heat pipe results in an uncertainty from 0.2 K to 2.4 K for the ITS-90 over the temperature range from 961.78 °C to 3,000 °C.

  18. ['Door de beugel': resorption at dental elements].

    PubMed

    Leunisse, M; Barendrecht, D S

    2015-09-01

    A twenty-year-old man was referred to an orthodontist for orthodontic re-treatment of dental element 32 by his dentist and a periodontist. At the buccal surface of the dental element a significant gingival resorption had occurred and the root of the element was located outside of the processus alveolaris buccally. This case will be presented at the thematic tour 'Door de beugel: team up' on 27 October 2015, which is organised by the Nederlandse Vereniging van Tandartsen (Dutch Dentists' Society) and will be held at 4 different locations in the Netherlands. Readers of the Nederlands Tijdschrift voor Tandheelkunde get an exclusive preview of the case. The treatment of choice will be published in the December 2015 issue.

  19. Validation of SCIAMACHY Ozone Column Densities and Profiles Using Ground-Based FTIR and Millimeter Wave Measurements

    NASA Astrophysics Data System (ADS)

    Kopp, G.; Blumenstock, Th.; Brinksma, E.; Eskes, H.; Griesfeller, A.; Hase, F.; Hochschild, G.; Kramer, I.; Mikuteit, S.; Raffalski, U.; van der A, R.

    2004-08-01

    Ground-based FTIR and millimeter wave measurements of the Institute of Meteorology and Climate Research (IMK), Forschungszentrum Karlsruhe, and the Swedish Institute of Space Physics (IRF) are used for validation of SCIAMACHY ozone measurements. FTIR and millimeter wave measurements used for this study were routinely carried out between 2002 and 2004 at IRF at Kiruna, Sweden. In addition IMK carried out millimeter wave measurements on Mount Zugspitze in the Alps in 2003. SCIAMACHY level 2 NRT-products of 2002 are only validated by FTIR data since millimeter wave observations started in late 2002 when SCIAMACHY data were unavailable. For the years 2003 and early 2004 total ozone column abundances retrieved with the TOSOMI algorithm of the Royal Netherlands Meteorological Institute (Koninklijk Nederlands Meteorologisch Instituut, KNMI) are validated by the FTIR and microwave measurements. Finally, ozone limb profiles between July and November 2002 taken from the current SCIA Level 2 Off-Line masterset are validated by the FTIR measurements at Kiruna

  20. Application of melt ejection criterion in simulation of micromachining with laser

    NASA Astrophysics Data System (ADS)

    Semak, Vladimir V.; Schriempf, J. T.; Knorovsky, G. A.; MacCallum, D. O.

    2003-07-01

    The theoretical criterion defining the threshold pulse energy and beam intensity required for melt ejection is proposed. The results of numerical simulation present dependencies of the threshold pulse energy and beam intensity as functions of laser pulse duration and beam radius. The experimental verification of proposed criterion is described and the comparison of theoretical predictions and measurements is presented. The criterion is applied for simulation of laser drilling metal foil with thickness in the range 25 μm - 125 μm using laser beam with 12 μm beam radius and pulse durations 10 ns and 100 ns. The computational results are used to interpret the results of experimental study of laser drilling of 125 μm aluminum foil using a single mode beam of a XeCl laser performed at the Nederlands Centrum voor Laser Research (NCLR) and the University of Twente. Additional results on Nd:YAG spot welds in pure Ni are also presented.

  1. Developments on the NMi-VSL traceable scanning probe microscope

    NASA Astrophysics Data System (ADS)

    Dirscherl, Kai; Koops, K. R.

    2003-11-01

    We will report on the progress of our project to realize a traceable Scanning Probe Microscope at the Van Swinden Laboratorium of the Nederlands Meetinstituut in the Netherlands. The traceable Atomic Force Microscope (AFM) is constructed from a separate AFM head, a 3D translation stage and an accurate 3D laser interferometer system. Nanometer uncertainty can be maintained in the entire scanning volume of 100 μm × 100 μm × 20 μm. Apart from providing direct traceability to the SI unit of length, the coordinates provided by the laser interferometer are also used in a closed loop position feedback controller to realize accurate positioning at arbitrary locations within the volume provided by the translation stage. In this paper we will emphasize the development of the control system.

  2. Dunlop receives European Geophysical Society's Néel Medal

    NASA Astrophysics Data System (ADS)

    Tauxe, Lisa

    David J. Dunlop of the Physics Department and Erindale College at the University of Toronto has been awarded the 1999 Louis Néel Medal of the European Geophysical Society (EGS) for “authoritative contributions to rock magnetism, setting the standards for future decades.” The medal will be presented to Dunlop in April in a special ceremony at the Nederlands Congresbebouw in The Hague, The Netherlands, during the 24th General Assembly of the EGS.The Néel Medal is awarded by the Solid Earth Geophysics section of EGS in recognition of the scientific achievements of Louis Néel, who shared the 1970 Nobel Prize in Physics for his fundamental discoveries in magnetism.The medal is awarded “for outstanding achievements in the fertilization of the Earth Sciences by the transfer and application of fundamental theory and/or experimental techniques of solid state physics, defined in its broadest sense.”

  3. Use of a laparoscopic retrieval device for urolith removal through a perineal urethrotomy.

    PubMed

    Inés, Martín Menéndez; Fitch, Gareth

    2012-07-01

    To report the use of a laparoscopic retrieval device for removal of uroliths via a perineal urethrotomy. Case report. A 12-year-old Konenklijk Warmbloed Paardenstamboek Nederland (KWPN) gelding and a 15-year-old Holsteiner gelding. Perineal urethrotomy was performed on 2 standing sedated geldings and the urolith was removed using a laparoscopic retrieval device. In both cases, uroliths were removed successfully with no short- or long-term complications. The larger of the 2 uroliths measured 6 cm in length and 4.6 cm in width. Removal of a urolith via a perineal urethrotomy using a laparoscopic retrieval device was an expedient and minimally traumatic method that obviated the need for fragmentation before removal. © Copyright 2012 by The American College of Veterinary Surgeons.

  4. [A series about the value of physical examination].

    PubMed

    de Jongh, T O H; Zaat, J O M

    2010-01-01

    This article is the introduction to a new series in the Nederlands Tijdschrift voor Geneeskunde about the value of physical examination. Associated with this series, on the website (www.ntvg.nl) there are chapters of the new textbook on physical examination and films about carrying out physical examinations. Although physical examination is an essential part of the diagnostic process, often little attention is paid to the correct execution of the examination and there is insufficient knowledge of the value of the findings. The diagnostic process usually involves analysing all the information from the patient's history and a physical examination. However, research has only been done on the value of specific tests and even that is very limited. The most important measure we use for the results of a physical examination is the likelihood ratio, which shows how the likelihood of presence or absence of a disease changes depending on the examination results.

  5. Workshop on Animal free Detection of Pertussis Toxin in Vaccines--Alternatives to the Histamine Sensitisation Test.

    PubMed

    Bache, Christina; Hoonakker, Marieke; Hendriksen, Coenraad; Buchheit, Karl-Heinz; Spreitzer, Ingo; Montag, Thomas

    2012-07-01

    The Paul-Ehrlich-Institut (PEI), the Nederlands Vaccin Instituut (NVI) and the European Directorate for the Quality of Medicines & HealthCare (EDQM) organised the international scientific workshop "Animal free Detection of Pertussis Toxin in Vaccines--Alternatives to the Histamine Sensitisation Test" at the PEI in Langen (Germany) on 09-10 June 2011. Twenty-seven experts (regulators, representatives from national control laboratories, vaccine manufacturers and academia) from 7 countries participated in this workshop. The meeting was triggered by the lack of satisfaction with the current safety testing for acellular pertussis vaccines, the "Histamine Sensitisation Test" (HIST) in mice, and the growing attention for the alternatives under development. The workshop objectives were: a) to review the current status of available alternative methods, b) to discuss the sensitivity that an alternative test needs, c) to plan experiments that allow for comparison of the alternative tests. The results of the workshop are summarised in this meeting report.

  6. The assessment of individual differences between young children with a pervasive developmental disorder by means of behaviour scales which are derived from direct observation.

    PubMed

    Althaus, M; Minderaa, R B; Dienske, H

    1994-02-01

    Data obtained by direct observation of 112 3-6-year-old normal children and 31 children with a pervasive developmental disorder aged 3-6 were used to construct behaviour scales by means of simultaneous component analysis. This is a technique for finding behaviour clusters (components) common to different groups by weighting the variables such that the resulting components maximize variance accounted for when summed over the groups (Milsap & Meredith, 1988, Psychometrika, 53, 123-134; Berge & Kiers, 1990, Nederlands Tijdschrift voor de Psychologie, 45, 221-226). An evaluation of the component structure that was found is given for both groups. Results show uncorrelated components for the normal group, while some of the same components are intercorrelated in the clinical group. Scales were constructed which are shown to have discriminative value with respect to subgroups within the group of patients.

  7. The Scars of Childhood Adversity: Minor Stress Sensitivity and Depressive Symptoms in Remitted Recurrently Depressed Adult Patients

    PubMed Central

    Burger, Huibert; Elgersma, Hermien; Riper, Heleen; Cuijpers, Pim; Dekker, Jack; Smit, Filip; Bockting, Claudi

    2014-01-01

    Background Childhood adversity may lead to depressive relapse through its long-lasting influence on stress sensitivity. In line with the stress sensitization hypothesis, minor (daily) stress is associated with depressive relapse. Therefore, we examine the impact of childhood adversity on daily stress and its predictive value on prospectively assessed depressive symptoms in recurrently depressed patients. Method Daily stress was assessed in recurrently depressed adult patients, enrolled into two randomized trials while remitted. The reported intensity and frequency of dependent and independent daily stress was assessed at baseline. Independent stress is externally generated, for example an accident happening to a friend, while dependent stress is internally generated, for example getting into a fight with a neighbor. Hierarchical regression analyses were performed with childhood adversity, independent and dependent daily stress as predictor variables of prospectively measured depressive symptoms after three months of follow-up (n = 138). Results We found that childhood adversity was not significantly associated with a higher frequency and intensity of daily stress. The intensity of both independent and dependent daily stress was predictive of depressive symptom levels at follow-up (unadjusted models respectively: B = 0.47, t = 2.05, p = 0.041, 95% CI = 0.02–0.92; B = 0.29, t = 2.20, p = 0.028, 95% CI = 0.03–0.55). No associations were found between childhood adversity and depressive symptoms at follow-up. Conclusion No evidence was found supporting stress sensitization due to the experience of childhood adversity in this recurrently depressed but remitted patient group. Nevertheless, our research indicates that daily stress might be a target for preventive treatment. Trial Registration Trial A: Nederlands Trial Register NTR1907 Trial B: Nederlands Trial Register NTR2503 PMID:25393812

  8. TU-AB-201-05: Automatic Adaptive Per-Operative Re-Planning for HDR Prostate Brachytherapy - a Simulation Study On Errors in Needle Positioning

    SciTech Connect

    Borot de Battisti, M; Maenhout, M; Lagendijk, J J W; Van Vulpen, M; Moerland, M A; Senneville, B Denis de

    2015-06-15

    errors in needle positioning and improve the dose distribution. Without re-optimization, target coverage and OAR constraints may not be achieved. M. Borot de Battisti is funded by Philips Medical Systems Nederland B.V.; M. Moerland is principal investigator on a contract funded by Philips Medical Systems Nederland B.V.; G. Hautvast and D. Binnekamp are full-time employees of Philips Medical Systems Nederland B.V.

  9. Effect of the colloids gelatin and HES 130/0.4 on blood coagulation in cardiac surgery patients: a randomized controlled trial.

    PubMed

    Kimenai, D M; Bastianen, G W; Daane, C R; Megens-Bastiaanse, C M; van der Meer, N J M; Scohy, T V; Gerritse, B M

    2013-11-01

    The choice of the prime solution for cardiopulmonary bypass can play an important role in limiting the effect on blood coagulation, but it is still unclear what the effect of colloids on blood coagulation is. The aim of this study was to investigate the effect of synthetic colloids on blood loss and blood coagulation in patients after on-pump coronary artery bypass graft (CABG) procedures. Sixty elective, on-pump CABG patients were randomly assigned to receive the prime solutions lactated Ringer's solution combined with hydroxyethyl starch 130/0.4 (HES, 6% Volulyte, Fresenius Kabi Nederland BV, Zeist, the Netherlands) (HES group) or gelatin (Gelofusin(®), B Braun Melsung AG, Melsungen, Germany) (Gelo group). Blood loss was assessed using post-operative chest tube output; secondary endpoints were number of blood component transfusions, routine coagulation test values and rotation thromboelastometry values (Rotem(®) delta, Pentapharm GmbH, Munich, Germany). Total post-operative chest tube output was 500 ± 420 ml in the HES group versus 465 ± 390 ml in the Gelo group (p = 0.48). No significant differences were observed in any of the routine coagulation tests values, thromboelastometry parameters or number of blood component transfusions between the groups. In this randomized, controlled trial of adults after on-pump CABG procedures, there was no significant difference in blood loss or blood coagulation between the HES group and the Gelo group.

  10. Development of a Solar Array Drive Assembly for CubeSat

    NASA Technical Reports Server (NTRS)

    Passaretti, Mike; Hayes, Ron

    2010-01-01

    Small satellites and in particular CubeSats, have increasingly become more viable as platforms for payloads typically requiring much larger bus structures. As advances in technology make payloads and instruments for space missions smaller, lighter and more power efficient, a niche market is emerging from the university community to perform rapidly developed, low-cost missions on very small spacecraft - micro, nano, and picosatellites. In just the last few years, imaging, biological and new technology demonstration missions have been either proposed or have flown using variations of the CubeSat structure as a basis. As these missions have become more complex, and the CubeSat standard has increased in both size (number of cubes) and mass, available power has become an issue. Body-mounted solar cells provide a minimal amount of power; deployable arrays improve on that baseline but are still limited. To truly achieve maximum power, deployed tracked arrays are necessary. To this end, Honeybee Robotics Spacecraft Mechanisms Corporation, along with MMA of Nederland Colorado, has developed a solar array drive assembly (SADA) and deployable solar arrays specifically for CubeSat missions. In this paper, we discuss the development of the SADA.

  11. Guideline for diagnosis and treatment of Waldenström's macroglobulinaemia.

    PubMed

    Vos, J M I; Minnema, M C; Wijermans, P W; Croockewit, S; Chamuleau, M E D; Pals, S T; Klein, S K; Delforge, M; van Imhoff, G W; Kersten, M J

    2013-03-01

    On behalf of the lymphoma and multiple myeloma working parties of the Dutch/Belgian Haemato-Oncology Foundation for Adults in The Netherlands (HOVON), we present a guideline for diagnosis and management of Waldenström's macroglobulinemia (WM). Considering the indolent behaviour and heterogeneous clinical presentation of WM, it is crucial to determine the right indications for treatment, as well as to individualise therapeutic options. There are significant differences from the approach to multiple myeloma or the treatment of other indolent non-Hodkgin lymphomas, and these results cannot always be extrapolated. There is a lack of large clinical trials due to the low incidence of WM. Based on the available data, we provide a practical diagnostic classification, as well as recommendations for first-line therapy and options for treating relapsed disease. Some typical clinical features of WM, such as autoimmune phenomena and 'IgM flare' after rituximab treatment, are highlighted. A more elaborate version of this guideline was published in the 'Nederlands Tijdschrift voor Hematologie' (Dutch Journal for Hematology) September 2012.

  12. The governance of quality management in dutch health care: new developments and strategic challenges.

    PubMed

    Maarse, J A M; Ruwaard, D; Spreeuwenberg, C

    2013-01-01

    This article gives a brief sketch of quality management in Dutch health care. Our focus is upon the governance of guideline development and quality measurement. Governance is conceptualized as the structure and process of steering of quality management. The governance structure of guideline development in the Netherlands can be conceptualized as a network without central coordination. Much depends upon the self-initiative of stakeholders. A similar picture can be found in quality measurement. Special attention is given to the development of care standards for chronic disease. Care standards have a broader scope than guidelines and take an explicit patient perspective. They not only contain evidence-based and up-to-date guidelines for the care pathway but also contain standards for self-management. Furthermore, they comprise a set of indicators for measuring the quality of care of the entire pathway covered by the standard. The final part of the article discusses the mission, tasks and strategic challenges of the newly established National Health Care Institute (Zorginstituut Nederland), which is scheduled to be operative in 2013.

  13. [Threshold value for reimbursement of costs of new drugs: cost-effectiveness research and modelling are essential links].

    PubMed

    Frederix, Geert W J; Hövels, Anke M; Severens, Johan L; Raaijmakers, Jan A M; Schellens, Jan H M

    2015-01-01

    There is increasing discussion in the Netherlands about the introduction of a threshold value for the costs per extra year of life when reimbursing costs of new drugs. The Medicines Committee ('Commissie Geneesmiddelen'), a division of the Netherlands National Healthcare Institute ('Zorginstituut Nederland'), advises on reimbursement of costs of new drugs. This advice is based upon the determination of therapeutic value of the drug and the results of economic evaluations. Mathematical models that predict future costs and effectiveness are often used in economic evaluations; these models can vary greatly in transparency and quality due to author assumptions. Standardisation of cost-effectiveness models is one solution to overcome the unwanted variation in quality. Discussions about the introduction of a threshold value can only be meaningful if all involved are adequately informed, and by high quality in cost-effectiveness research and, particularly, economic evaluations. Collaboration and discussion between medical specialists, patients or patient organisations, health economists and policy makers, both in development of methods and in standardisation, are essential to improve the quality of decision making.

  14. Salivary Immunoglobulin Gene Expression in Patients with Caries

    PubMed Central

    Santín, Gema Regina Guadarrama; Salgado, Angel Visoso; Bastida, Norma Margarita Montiel; Gómez, Isaías de la Rosa; Benítez, Jonnathan Guadalupe Santillán; Zerón, Hugo Mendieta

    2017-01-01

    BACKGROUND: Immunoglobulins mediate the host’s humoral immune response are expressed in saliva. AIM: To quantify the FcαR, FcγRIIB, and FcαμR gene expression in the saliva of Mexican patients with caries in mixed and permanent dentition. SUBJECTS AND METHODS: This was a comparative cross-sectional study. mRNA was isolated from 200 μL of saliva following the RNA III Tissue Fresh-frozen protocol of the MagNA Pure LC Instrument 2.0 (Roche Diagnostics GmbH, Nederland BV) and the FcαR, FcαμR and FcγRIIB were quantified through TaqMan Assays. RESULTS: One hundred individuals, 50 with mixed dentition and 50 with permanent dentition, were included in the study. Statistically, it was found a significant difference (p = 0.025) in the IgG (FcγRIIB) expression between the studied groups. CONCLUSION: Although we confirmed the existence of FcαR, FcγRIIB and FcαμR gene expression in saliva, only a significant difference in the expression of FcγRIIB between the mixed dentition and permanent dentition was found. PMID:28507635

  15. The effectiveness of problem solving therapy for stroke patients: study protocol for a pragmatic randomized controlled trial.

    PubMed

    Visser, Marieke M; Heijenbrok-Kal, Majanka H; van 't Spijker, Adriaan; Ribbers, Gerard M; Busschbach, Jan J V

    2013-06-27

    Coping style is one of the determinants of health-related quality of life after stroke. Stroke patients make less use of active problem-oriented coping styles than other brain damaged patients. Coping styles can be influenced by means of intervention. The primary aim of this study is to investigate if Problem Solving Therapy is an effective group intervention for improving coping style and health-related quality of life in stroke patients. The secondary aim is to determine the effect of Problem Solving Therapy on depression, social participation, health care consumption, and to determine the cost-effectiveness of the intervention. We strive to include 200 stroke patients in the outpatient phase of rehabilitation treatment, using a multicenter pragmatic randomized controlled trial with one year follow-up. Patients in the intervention group will receive Problem Solving Therapy in addition to the standard rehabilitation program. The intervention will be provided in an open group design, with a continuous flow of patients. Primary outcome measures are coping style and health-related quality of life. Secondary outcome measures are depression, social participation, health care consumption, and the cost-effectiveness of the intervention. We designed our study as close to the implementation in practice as possible, using a pragmatic randomized trial and open group design, to represent a realistic estimate of the effectiveness of the intervention. If effective, Problem Solving Therapy is an inexpensive, deliverable and sustainable group intervention for stroke rehabilitation programs. Nederlands Trial Register, NTR2509.

  16. Inducing Expectations for Health: Effects of Verbal Suggestion and Imagery on Pain, Itch, and Fatigue as Indicators of Physical Sensitivity

    PubMed Central

    Peerdeman, Kaya J.; van Laarhoven, Antoinette I. M.; Donders, A. Rogier T.; Hopman, Maria T. E.; Peters, Madelon L.; Evers, Andrea W. M.

    2015-01-01

    Research into placebo effects has convincingly shown that inducing positive outcome expectations can reduce pain and other physical sensations. However, the comparative effects of different expectation inductions, such as verbal suggestion or mental imagery, and their generic effects on physical sensitivity, to different sensations such as pain, itch, and fatigue, are still largely unknown. In the current study, we assessed the individual and combined effects of verbal suggestion and imagery on pain, itch, and fatigue as indicators of physical sensitivity in a randomized study design. Healthy participants (n = 116) were given an inert (placebo) capsule that was said to be effective for reducing physical sensitivity in either the majority (positive verbal suggestion) or the minority (control verbal suggestion) of users. Subsequently, they imagined either their best possible health (positive imagery) or a typical day (control imagery). Sensitivity to pain, itch, and fatigue was tested using a cold pressor test, histamine iontophoresis, and a bicycle test, respectively. Heart rate and skin conductance were recorded continuously. Results showed that positive verbal suggestion and imagery successfully induced positive expectations, but they did not affect physical sensitivity, as indicated by sensitivity to pain, itch, or fatigue, or concurrent physiological responses. These results could indicate that the specificity and concreteness of expectation inductions might be important for their applicability in the treatment of physical symptoms. Trial Registration Nederlands Trial Register NTR3641 PMID:26448183

  17. The meaning of "significance" for different types of research [translated and annotated by Eric-Jan Wagenmakers, Denny Borsboom, Josine Verhagen, Rogier Kievit, Marjan Bakker, Angelique Cramer, Dora Matzke, Don Mellenbergh, and Han L. J. van der Maas]. 1969.

    PubMed

    de Groot, A D

    2014-05-01

    Adrianus Dingeman de Groot (1914-2006) was one of the most influential Dutch psychologists. He became famous for his work "Thought and Choice in Chess", but his main contribution was methodological--De Groot co-founded the Department of Psychological Methods at the University of Amsterdam (together with R. F. van Naerssen), founded one of the leading testing and assessment companies (CITO), and wrote the monograph "Methodology" that centers on the empirical-scientific cycle: observation-induction-deduction-testing-evaluation. Here we translate one of De Groot's early articles, published in 1956 in the Dutch journal Nederlands Tijdschrift voor de Psychologie en Haar Grensgebieden. This article is more topical now than it was almost 60years ago. De Groot stresses the difference between exploratory and confirmatory ("hypothesis testing") research and argues that statistical inference is only sensible for the latter: "One 'is allowed' to apply statistical tests in exploratory research, just as long as one realizes that they do not have evidential impact". De Groot may have also been one of the first psychologists to argue explicitly for preregistration of experiments and the associated plan of statistical analysis. The appendix provides annotations that connect De Groot's arguments to the current-day debate on transparency and reproducibility in psychological science. Copyright © 2014 Elsevier B.V. All rights reserved.

  18. AIV Platform for the Galileo Precise Timing Facility

    NASA Astrophysics Data System (ADS)

    Oving, B. A.; Kroon, E.

    2008-08-01

    The Precise Timing Facility (PTF) is an element of the Galileo Ground Mission Segment (GMS) and is responsible for maintaining and distributing the Galileo System Time (GST). The PTF is based on a set of Caesium clocks and Active Hydrogen Maser clocks, the combination of which should be able to provide the required precision and stability of the GST. As the PTF is a critical element within the GMS, diversity is applied in that two PTFs are made by two different companies. The subject of this paper is the PTF that is being developed by Kayser-Threde. To perform the Assembly, Integration and Verification (AIV) activities of the PTF, a dedicated test platform, PTF-AIVP, is developed by the National Aerospace Laboratory, NLR (the Netherlands) and the Nederlands Meetinstituut (NMi). The PTF-AIVP will be used to measure and analyse the (physical) output of the PTF, so that the stringent precision and stability requirements can be verified. Furthermore, it will simulate other Elements in the GMS that are connected to the PTF.

  19. The continuing story of nutritional supplements and doping infractions

    PubMed Central

    de Hon, Olivier; Coumans, Bart

    2007-01-01

    Nutritional supplements can be a source of positive doping cases as some supplements contain prohibited substances without showing this on their label. This problem has existed for some time and has been extensively studied in the past 8 years. The sport of tennis has played a particular role in this problem because of some peculiar doping cases within its community. This article focuses on this particular doping problem, explaining the background and reviewing the available literature. It presents the first 3 years of experience within the Netherlands Security System Nutritional Supplements Elite Sports (“Nederlands Zekerheidssysteem Voedingssupplementen Topsport” or NZVT) and explains the most extensive system established to combat this particular doping problem. The NZVT experience has shown that paper‐based quality systems are still prone to possible contaminations, which leads to the conclusion that the best possible solution for athletes who wish to use nutritional supplements must include laboratory‐based analysis for doping substances, preferably repeated for every new batch. The most important educational message, however, is to use a nutritional supplement only if it is deemed of benefit by a nutritional expert. PMID:17957017

  20. Correcting the planar perspective projection in geometric structures applied to forensic facial analysis.

    PubMed

    Baldasso, Rosane Pérez; Tinoco, Rachel Lima Ribeiro; Vieira, Cristina Saft Matos; Fernandes, Mário Marques; Oliveira, Rogério Nogueira

    2016-10-01

    The process of forensic facial analysis may be founded on several scientific techniques and imaging modalities, such as digital signal processing, photogrammetry and craniofacial anthropometry. However, one of the main limitations in this analysis is the comparison of images acquired with different angles of incidence. The present study aimed to explore a potential approach for the correction of the planar perspective projection (PPP) in geometric structures traced from the human face. A technique for the correction of the PPP was calibrated within photographs of two geometric structures obtained with angles of incidence distorted in 80°, 60° and 45°. The technique was performed using ImageJ(®) 1.46r (National Institutes of Health, Bethesda, Maryland). The corrected images were compared with photographs of the same object obtained in 90° (reference). In a second step, the technique was validated in a digital human face created using MakeHuman(®) 1.0.2 (Free Software Foundation, Massachusetts, EUA) and Blender(®) 2.75 (Blender(®) Foundation, Amsterdam, Nederland) software packages. The images registered with angular distortion presented a gradual decrease in height when compared to the reference. The digital technique for the correction of the PPP is a valuable tool for forensic applications using photographic imaging modalities, such as forensic facial analysis.

  1. A cluster randomized controlled trial on the effects and costs of advance care planning in elderly care: study protocol.

    PubMed

    Korfage, Ida J; Rietjens, Judith A C; Overbeek, Anouk; Jabbarian, Lea J; Billekens, Pascalle; Hammes, Bernard J; Hansen-van der Meer, Ellen; Polinder, Suzanne; Severijnen, Johan; Swart, Siebe J; Witkamp, Frederika E; van der Heide, Agnes

    2015-07-22

    Currently, health care and medical decision-making at the end of life for older people are often insufficiently patient-centred. In this trial we study the effects of Advance Care Planning (ACP), a formalised process of timely communication about care preferences at the end of life, for frail older people. We will conduct a cluster randomised controlled trial among older people residing in care homes or receiving home care in the Netherlands. The intervention group will receive the ACP program Respecting Choices® in addition to usual care. The control group will receive usual care only. Participants in both groups will fill out questionnaires at baseline and after 12 months. We hypothesize that ACP will lead to better patient activation in medical decision making and quality of life, while reducing the number of medical interventions and thus health care costs. Multivariate analysis will be used to compare differences between the intervention group and the control group at baseline and to compare differences in changes after 12 months following the inclusion. Our study can contribute to more understanding of the effects of ACP on patient activation and quality of life in frail older people. Further, we will gain insight in the costs and cost-effectiveness of ACP. This study will facilitate ACP policy for older people in the Netherlands. Nederlands Trial Register: NTR4454.

  2. A novel acoustic method for gas flow measurement using correlation techniques

    NASA Astrophysics Data System (ADS)

    Knuuttila, Matti Tapani

    The study demonstrates a new kind of acoustic method for gas flow measurement. The method uses upstream and downstream propagating low frequency plane wave and correlation techniques for volume flow rate determination. The theory of propagating low frequency plane waves in the pipe is introduced and is proved empirically to be applicable for flow measurement. The flow profile dependence of the method is verified and found to be negligible at least in the region of moderate perturbations. The physical principles of the method were applied in practice in the form of a flowmeter with new design concepts. The developed prototype meters were verified against the reference standard of NMI (Nederlands Meetinstituut), which showed that a wide dynamic range of 1:80 is achievable with total expanded uncertainty below 0.3%. Also the requirements used for turbine meters of linearity, weighted mean error and stability were shown to be well fulfilled. A brief comparison with other flowmeter types shows the new flowmeter to be competitive. The advantages it offers are a small pressure drop over the meter, no blockage of flow in possible malfunction, no pulsation to flow, essentially no moving parts, and the possibility for bidirectional measurements. The introduced flowmeter is also capable of using the introduced flowmeter is also capable of using the telephone network or a radio-modem to read the consumption of gas and report its operation to the user.

  3. All solid-state diode pumped Nd:YAG MOPA with stimulated Brillouin phase conjugate mirror

    NASA Astrophysics Data System (ADS)

    Offerhaus, H. L.; Godfried, H. P.; Witteman, W. J.

    1996-02-01

    At the Nederlands Centrum voor Laser Research (NCLR) a 1 kHz diode-pumped Nd:YAG Master Oscillator Power Amplifier (MOPA) chain with a Stimulated Brillouin Scattering (SBS) Phase Conjugate mirror is designed and operated. A small Brewster angle Nd:YAG slab (2 by 2 by 20 mm) is side pumped with 200 μs diode pulses in a stable oscillator. The oscillator is Q-switched and injection seeded with a commercial diode pumped single frequency CW Nd:YAG laser. The output consists of single-transverse, single-longitudinal mode 25 ns FWHM-pulses at 1064 nm. The oscillator slab is imaged on a square aperture that transmits between 3 and 2 mJ (at 100 and 400 Hz, resp.) The aperture is subsequently imaged four times in the amplifier. The amplifier is a 3 by 6 by 60 mm Brewster angle zig-zag slab, pumped by an 80-bar diode stack with pulses up to 250 μs. After the second pass the light is focused in two consecutive cells containing Freon-113 for wave-front reversal in an oscillator/amplifier-setup with a reflectivity of 60%. The light then passes through the amplifier twice more to produce 20 W (at 400 Hz) of output with near diffraction limited beam quality. To increase the output to 50 W at 1 kHz thermal lensing in the oscillator will be reduced.

  4. Guided self-help on the internet for turkish migrants with depression: the design of a randomized controlled trial

    PubMed Central

    2010-01-01

    Background The Turkish population living in the Netherlands has a high prevalence of psychological complaints and has a high threshold for seeking professional help for these problems. Seeking help through the Internet can overcome these barriers. This project aims to evaluate the effectiveness of a guided self-help problem-solving intervention for depressed Turkish migrants that is culturally adapted and web-based. Methods This study is a randomized controlled trial with two arms: an experimental condition group and a wait list control group. The experimental condition obtains direct access to the guided web-based self-help intervention, which is based on Problem Solving Treatment (PST) and takes 6 weeks to complete. Turkish adults with mild to moderate depressive symptoms will be recruited from the general population and the participants can choose between a Turkish and a Dutch version. The primary outcome measure is the reduction of depressive symptoms, the secondary outcome measures are somatic symptoms, anxiety, acculturation, quality of life and satisfaction. Participants are assessed at baseline, post-test (6 weeks), and 4 months after baseline. Analysis will be conducted on the intention-to-treat sample. Discussion This study evaluates the effectiveness of a guided problem-solving intervention for Turkish adults living in the Netherlands that is culturally adapted and web-based. Trial Registration Nederlands Trial Register: NTR2303 PMID:21047442

  5. High cereblon expression is associated with better survival in patients with newly diagnosed multiple myeloma treated with thalidomide maintenance.

    PubMed

    Broyl, Annemiek; Kuiper, Rowan; van Duin, Mark; van der Holt, Bronno; el Jarari, Laila; Bertsch, Uta; Zweegman, Sonja; Buijs, Arjan; Hose, Dirk; Lokhorst, Henk M; Goldschmidt, Hartmut; Sonneveld, Pieter

    2013-01-24

    Recently, cereblon (CRBN) expression was found to be essential for the activity of thalidomide and lenalidomide. In the present study, we investigated whether the clinical efficacy of thalidomide in multiple myeloma is associated with CRBN expression in myeloma cells. Patients with newly diagnosed multiple myeloma were included in the HOVON-65/GMMG-HD4 trial, in which postintensification treatment in 1 arm consisted of daily thalidomide (50 mg) for 2 years. Gene-expression profiling, determined at the start of the trial, was available for 96 patients who started thalidomide maintenance. In this patient set, increase of CRBN gene expression was significantly associated with longerprogression-free survival (P = .005). In contrast, no association between CRBN expression and survival was observed in the arm with bortezomib maintenance. We conclude that CRBN expression may be associated with the clinical efficacy of thalidomide. This trial has been registered at the Nederlands Trial Register (www.trialregister.nl) as NTR213; at the European Union Drug Regulating Authorities Clinical Trials (EudraCT) as 2004-000944-26; and at the International Standard Randomized Controlled Trial Number (ISRCTN) as 64455289.

  6. Components of the metabolic syndrome in 500 adult long-term survivors of childhood cancer.

    PubMed

    van Waas, M; Neggers, S J C M M; Pieters, R; van den Heuvel-Eibrink, M M

    2010-05-01

    Adult survivors of childhood cancer have been reported to have an increased risk of late sequels. A cluster of abnormalities that contribute to the metabolic syndrome may be expressed at a higher level and therefore result in an increased risk for diabetes mellitus and cardiovascular diseases. We investigated a single-centre cohort of 500 adult survivors (228 females) of childhood cancer, median age 28 years (range 18-59 years) and median follow-up time 19 years (range 6-49 years). We measured total cholesterol, high-density lipoprotein-cholesterol, systolic and diastolic blood pressure, body mass index and the prevalence of diabetes mellitus. Data from the epidemiological Monitoring van Risicofactoren en Gezondheid in Nederland (MORGEN) study were used to calculate standard deviation scores as normative values. The criteria of the metabolic syndrome were met in 13% of the total cohort. Acute lymphoblastic leukaemia (ALL) survivors treated with cranial irradiation had an increased risk of developing the metabolic syndrome compared with ALL survivors not treated with cranial irradiation (23% versus 7%, P = 0.011), probably determined by higher prevalence of overweight and hypertension. Adult survivors of childhood cancer, especially those treated with cranial irradiation, are at increased risk of developing the metabolic syndrome.

  7. [Medical Officer Ellerman, lecturer in pharmacology and editor of the Nederlandsch Lancet].

    PubMed

    Verhoeven, Patrick P A M; Bolk, Jan H

    2011-01-01

    George Lievin Henri Ellerman (1817-1849) followed his medical-military training at the Military Medical Training College (RKMG) in Utrecht, the Netherlands, from 1835 to 1839, and gained his PhD from Leiden University in 1841. From 1843 to 1849 he was a lecturer in pharmacology at the RKMG. He was one of the first editors of the Nederlandsch Lancet. Together with his fellow board members Donders and Jansen he set this journal on a new course. Due to the new mix of scientific and practice-oriented articles the journal developed into the most important medical scientific journal in the Netherlands; it was however not among the journals that merged to become the Nederlands Tijdschrift voor Geneeskunde [Dutch Journal of Medicine]. In 1846 Ellerman published a Dutch translation of Friedrich Oesterlen's textbook of pharmacology 'Handbuch der Heilmittellehre'. This book was considered to be a complete and lucid survey of pharmacology and a major step towards a more scientific pharmacology. After his death at the age of 32, he was remembered as a good scientist and dedicated, hardworking lecturer.

  8. Herschel: Testing of Cryogenics Instruments at Spacecraft Level and Early Flight Results

    NASA Astrophysics Data System (ADS)

    Collaudin, B.; Montet, D.; Roche, Y.; Ilsen, S.; Schamberg, C.; Cesa, M.; Goodey, K.; Rautakoski, J.; Jewell, C.; Idler, S.; Koppe, A.; Sonn, N.; Hendry, D.; Hamer, S.; Bauer, O.; Feuchtgruber, H.; Sawyer, E.; Swinyard, B.; Sidher, S.; Roelfsema, P.; Dieleman, P.; Teyssier, D.

    2010-04-01

    Herschel cryogenics instrument (HIFI, PACS, SPIRE) flight models have been delivered to ESA & Prime contractor Thales Alenia Space mid 2007, to be integrated and tested on the Herschel spacecraft, for a launch mid May 2009. The instrument integration and test campaign at spacecraft level was performed between mid 2007 and end 2008 in Astrium GmbH, Immenstadt (Gernany) and later in ESA's test facilities at Estec, Noordwijk (Nederland). The objective of these tests was to demonstrate full operability and performances of the instruments in spacecraft configuration, and their compatibility with the launch and space environment, while maintaining full compliance with the underlying requirements. A set of short functional tests were developed and used repeatedly to quickly check the health of each instrument at key points in the test campaign. Typically, this was after integration of a major component, prior to a major environmental test or before/after movement of the spacecraft. A set of full functional tests were also performed after launch vibration tests, and during Thermal vacuum test in order to provide a more complete picture of the instruments functional health. Finally a set of unstrument specific tests were performed to verify the performance of the instrument under the most representative operational conditions possible on ground (i.e. the environmental test compaign). The paper will describe instruments and the instruments related tests performed at spacecraft level, focusing on cryogenics aspects.

  9. The Efficacy of Mindfulness-Based Cognitive Therapy as a Public Mental Health Intervention for Adults with Mild to Moderate Depressive Symptomatology: A Randomized Controlled Trial

    PubMed Central

    Pots, Wendy T. M.; Meulenbeek, Peter A. M.; Veehof, Martine M.; Klungers, Jorinde; Bohlmeijer, Ernst T.

    2014-01-01

    Objective Although there has been growing evidence for the efficacy of mindfulness-based cognitive therapy (MBCT) for different clinical populations, its effectiveness as a public mental health intervention has not been studied. The present study evaluates a community-based MBCT intervention for adults with mild to moderate depressive symptomatology in a large multi-site, pragmatic randomized controlled trial. Method The participants with mild to moderate depressive symptomatology were recruited from the general population and randomized to the MBCT intervention (n = 76) or to a waiting list control group (n = 75). Participants completed measures before and after the intervention. Participants in the experimental condition also completed these measures at a 3-month follow-up. Results In the experimental condition significant reductions in depression, anxiety, and experiential avoidance, and improvements in mindfulness and emotional- and psychological mental health were found, compared to the waiting list (effect sizes Cohen's d = 0.31–0.56). These effects were sustained at the 3-month follow-up. The likelihood of a clinically significant change in depressive symptoms was significantly higher for the MBCT group [odds ratio (OR) 3.026, p<0.01 at post-treatment; NNT = 5.10]. Discussion MBCT as a public mental health intervention for adults with mild to moderate depressive symptoms seems effective and applicable in a natural setting. Trial Registration Nederlands Trial Register NTR2096 PMID:25333885

  10. [The role of consultation in palliative sedation in the central region of the Netherlands].

    PubMed

    de Graeff, A; Jobse, A P; Verhagen, E H; Moonen, A A J

    2008-10-25

    To gain insight into the role of consultation in palliative sedation. Retrospective analysis. All consultation records of the Palliation Team Midden Nederland (PTMN) from 1 November 2005 to 31 October 2006 were analysed. If palliative sedation was mentioned in the record, the following variables were listed: character of the consultation, data of the questioner, patient data, consultation question, indication for palliative sedation, and character of the advice given. Palliative sedation was a topic in 206 of the 659 consultation records investigated (31%). Intractable delirium, pain, exhaustion, dyspnoea and nausea or vomiting were the most important grounds for palliative sedation. In 47 of the 113 consultations (41%) about starting palliative sedation a negative advice was given, and this was nearly always because there were no intractable somatic symptoms. Existential problems played an important role in 14 of these 113 consultations (12%). In 25 consultations (22%) euthanasia versus palliative sedation was considered explicitly. For these cases there was hardly ever an indication for sedation. Palliative sedation was an important reason for consulting the PTMN. The high percentage of negative advice indicates that consultation about palliative sedation has an added value. It gives the questioner the opportunity to check whether all options for treatment have been tried. The question as to whether existential problems are an indication for palliative sedation should be discussed between medical professionals as well as publicly. Palliative sedation rarely is an alternative for euthanasia.

  11. Social networks of health care providers and patients in cardiovascular risk management: a study protocol

    PubMed Central

    2014-01-01

    Background In recent years, preventive and clinical interventions for cardiovascular risk management have been implemented widely in primary care in the Netherlands. Although this has enhanced quality and outcomes of cardiovascular risk management, further improvement remains possible. In the planned observational study, we aim to examine the role of social networks of healthcare providers and patients in quality and outcomes of cardiovascular risk management. Methods/Design In a longitudinal observational study, data on social networks of approximately 300 primary care providers from 30 general practices and 900 cardiovascular patients will be collected twice, with a six month interval, using a mix of measures. Social networks are documented with specifically designed questionnaires for patients, relatives, and healthcare professionals. For each included patient, we will extract from medical records to gather data on clinical processes and cardiovascular risk predictors. Data on self-management and psychosocial outcomes of patients will be collected using questionnaires for patients. The analysis focuses on identifying network characteristics, which are associated with (changes in) cardiovascular risk management or self-management. Discussion This research will provide insight into the role of social networks of patients and providers in cardiovascular risk management in primary practice. Trial registration Nederlands Trial Register NTR4069. PMID:24942555

  12. Assessment of relative accuracy of AHN-2 laser scanning data using planar features.

    PubMed

    van der Sande, Corné; Soudarissanane, Sylvie; Khoshelham, Kourosh

    2010-01-01

    AHN-2 is the second part of the Actueel Hoogtebestand Nederland project, which concerns the acquisition of high-resolution altimetry data over the entire Netherlands using airborne laser scanning. The accuracy assessment of laser altimetry data usually relies on comparing corresponding tie elements, often points or lines, in the overlapping strips. This paper proposes a new approach to strip adjustment and accuracy assessment of AHN-2 data by using planar features. In the proposed approach a transformation is estimated between two overlapping strips by minimizing the distances between points in one strip and their corresponding planes in the other. The planes and the corresponding points are extracted in an automated segmentation process. The point-to-plane distances are used as observables in an estimation model, whereby the parameters of a transformation between the two strips and their associated quality measures are estimated. We demonstrate the performance of the method for the accuracy assessment of the AHN-2 dataset over Zeeland province of The Netherlands. The results show vertical offsets of up to 4 cm between the overlapping strips, and horizontal offsets ranging from 2 cm to 34 cm.

  13. A randomised controlled trial of aerobic exercise after transient ischaemic attack or minor stroke to prevent cognitive decline: the MoveIT study protocol.

    PubMed

    Boss, H M; Van Schaik, S M; Deijle, I A; de Melker, E C; van den Berg, B T J; Scherder, E J A; Bosboom, W M J; Weinstein, H C; Van den Berg-Vos, R M

    2014-12-31

    Patients with transient ischaemic attack (TIA) or stroke are at risk for cognitive impairment and dementia. Currently, there is no known effective strategy to prevent this cognitive decline. Increasing evidence exists that physical exercise is beneficial for cognitive function. However, in patients with TIA or stroke who are at risk of cognitive impairment and dementia, only a few trials have been conducted. In this study, we aim to investigate whether a physical exercise programme (MoveIT) can prevent cognitive decline in patients in the acute phase after a TIA or minor ischaemic stroke. A single-blinded randomised controlled trial will be conducted to investigate the effect of an aerobic exercise programme on cognition compared with usual care. 120 adult patients with a TIA or minor ischaemic stroke less than 1 month ago will be randomly allocated to an exercise programme consisting of a 12-week aerobic exercise programme and regular follow-up visits to a specialised physiotherapist during the period of 1 year or to usual care. Outcome measures will be assessed at the baseline, and at the 1-year and 2-year follow-up. The primary outcome is cognitive functioning measured with the Montreal Cognitive Assessment (MoCA) test and with additional neuropsychological tests. Secondary outcomes include maximal exercise capacity, self-reported physical activity and measures of secondary prevention. The study received ethical approval from the VU University Amsterdam Ethics committee (2011/383). The results of this study will be published in peer-reviewed journals and presented at international conferences. We will also disseminate the main results to our participants in a letter. The Nederlands Trial Register NTR3884. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  14. Impact of a Clinical Decision Model for Febrile Children at Risk for Serious Bacterial Infections at the Emergency Department: A Randomized Controlled Trial

    PubMed Central

    de Vos-Kerkhof, Evelien; Nijman, Ruud G.; Vergouwe, Yvonne; Polinder, Suzanne; Steyerberg, Ewout W.; van der Lei, Johan; Moll, Henriëtte A.; Oostenbrink, Rianne

    2015-01-01

    Nederlands Trial Register NTR2381 PMID:26024532

  15. Within-class differences in cancer risk for sulfonylurea treatments in patients with type 2 diabetes (ZODIAC-55) - a study protocol.

    PubMed

    Schrijnders, Dennis; de Bock, Geertruida H; Houweling, Sebastiaan T; van Hateren, Kornelis J J; Groenier, Klaas H; Johnson, Jeffrey A; Bilo, Henk J G; Kleefstra, Nanne; Landman, Gijs W D

    2017-06-23

    Patients with type 2 diabetes (T2D) are at increased risk for developing cancer. As approximately 8% of the world's population is living with T2D, even a slight increase in cancer risk could result in an enormous impact on the number of persons developing cancer. In addition, several glucose lowering drug classes for treating patients with T2D have been associated with a difference in risk of cancer overall, and especially for obesity related cancers. In what way and to what degree cancer risk is modified by the use of different sulfonylureas (SU) is unclear. The primary aim of this study will be to evaluate within-class SU differences in obesity related cancer risk. Secondary aims will be to investigate within-class SU differences in risk for all cancers combined and site-specific cancers separately (i.e. breast, colorectal, prostate, bladder and lung cancer) and to account for duration-response relationships between individual SU use and cancer risk. Patients will be selected from a Dutch primary care cohort of patients with T2D linked with the Dutch Cancer Registration (ZODIAC-NCR). Within this cohort study annually collected clinical data (e.g. blood pressure, weight, HbA1c) and nationwide data on cancer incidence are available. Time-dependent cox proportional hazard analyses will be performed to evaluate SU cancer risk, adjusted for potential confounders. This study will be the first prospective cohort study investigating within-class SU differences in cancer risk and could contribute to improved decision making regarding the individual drugs within the class of SUs, and possibly improve quality of life and result in an increased cost-effectiveness of healthcare in patients with T2D. Nederlands Trialregister ( NTR6166 ), 6 Jan 2017.

  16. Laparoscopic ileocolic resection versus infliximab treatment of distal ileitis in Crohn's disease: a randomized multicenter trial (LIR!C-trial)

    PubMed Central

    Eshuis, Emma J; Bemelman, Willem A; van Bodegraven, Ad A; Sprangers, Mirjam AG; Bossuyt, Patrick MM; de Wit, AW Marc van Milligen; Crolla, Rogier MPH; Cahen, Djuna L; Oostenbrug, Liekele E; Sosef, Meindert N; Voorburg, Annet MCJ; Davids, Paul HP; van der Woude, C Janneke; Lange, Johan; Mallant, Rosalie C; Boom, Maarten J; Lieverse, Rob J; van der Zaag, Edwin S; Houben, Martin HMG; Vecht, Juda; Pierik, Robert EGJM; van Ditzhuijsen, Theo JM; Prins, Hubert A; Marsman, Willem A; Stockmann, Henricus B; Brink, Menno A; Consten, Esther CJ; van der Werf, Sjoerd DJ; Marinelli, Andreas WKS; Jansen, Jeroen M; Gerhards, Michael F; Bolwerk, Clemens JM; Stassen, Laurents PS; Spanier, BW Marcel; Bilgen, Ernst Jan Spillenaar; van Berkel, Anne-Marie; Cense, Huib A; van Heukelem, Henk A; van de Laar, Arnold; Slot, Warner Bruins; Eijsbouts, Quirijn A; van Ooteghem, Nancy AM; van Wagensveld, Bart; van den Brande, Jan MH; van Geloven, Anna AW; Bruin, Karien F; Maring, John K; Oldenburg, Bas; van Hillegersberg, Richard; de Jong, Dirk J; Bleichrodt, Robert; van der Peet, Donald L; Dekkers, Pascal EP; Goei, T Hauwy; Stokkers, Pieter CF

    2008-01-01

    best treatment for recurrent distal ileitis in Crohn's disease. Trial registration Nederlands Trial Register NTR1150 PMID:18721465

  17. Feasibility of portal dosimetry for flattening filter-free radiotherapy.

    PubMed

    Chuter, Robert W; Rixham, Philip A; Weston, Steve J; Cosgrove, Vivian P

    2016-01-08

    The feasibility of using portal dosimetry (PD) to verify 6 MV flattening filter-free (FFF) IMRT treatments was investigated. An Elekta Synergy linear accelerator with an Agility collimator capable of delivering FFF beams and a standard iViewGT amorphous silicon (aSi) EPID panel (RID 1640 AL5P) at a fixed SSD of 160 cm were used. Dose rates for FFF beams are up to four times higher than for conventional flattened beams, meaning images taken at maximum FFF dose rate can saturate the EPID. A dose rate of 800 MU/min was found not to saturate the EPID for open fields. This dose rate was subsequently used to characterize the EPID for FFF portal dosimetry. A range of open and phantom fields were measured with both an ion chamber and the EPID, to allow comparison between the two. The measured data were then used to create a model within The Nederlands Kanker Instituut's (NKI's) portal dosimetry software. The model was verified using simple square fields with a range of field sizes and phantom thicknesses. These were compared to calculations performed with the Monaco treatment planning system (TPS) and isocentric ion chamber measurements. It was found that the results for the FFF verification were similar to those for flattened beams with testing on square fields, indicating a difference in dose between the TPS and portal dosimetry of approximately 1%. Two FFF IMRT plans (prostate and lung SABR) were delivered to a homogeneous phantom and showed an overall dose difference at isocenter of ~0.5% and good agreement between the TPS and PD dose distributions. The feasibility of using the NKI software without any modifications for high-dose-rate FFF beams and using a standard EPID detector has been investigated and some initial limitations highlighted.

  18. Adherence to and effectiveness of an individually tailored home-based exercise program for frail older adults, driven by mobility monitoring: design of a prospective cohort study.

    PubMed

    Geraedts, Hilde A E; Zijlstra, Wiebren; Zhang, Wei; Bulstra, Sjoerd; Stevens, Martin

    2014-06-07

    -based exercise programs. Nederlands Trial Register (NTR); trial number 4265. The study was prospectively registered (registration date 14/11/2013).

  19. Cost-effectiveness of problem-solving treatment in comparison with usual care for primary care patients with mental health problems: a randomized trial

    PubMed Central

    2012-01-01

    Background Mental health problems are common and are associated with increased disability and health care costs. Problem-Solving Treatment (PST) delivered to these patients by nurses in primary care might be efficient. The aim of this study was to evaluate the cost-effectiveness of PST by mental health nurses compared with usual care (UC) by the general practitioner for primary care patients with mental health problems. Methods An economic evaluation from a societal perspective was performed alongside a randomized clinical trial. Patients with a positive General Health Questionnaire score (score ≥ 4) and who visited their general practitioner at least three times during the past 6 months were eligible. Outcome measures were improvement on the Hospital Anxiety and Depression Scale and QALYs based on the EQ-5D. Resource use was measured using a validated questionnaire. Missing cost and effect data were imputed using multiple imputation techniques. Bootstrapping was used to analyze costs and cost-effectiveness of PST compared with UC. Results There were no statistically significant differences in clinical outcomes at 9 months. Mean total costs were €4795 in the PST group and €6857 in the UC group. Costs were not statistically significantly different between the two groups (95% CI -4698;359). The cost-effectiveness analysis showed that PST was cost-effective in comparison with UC. Sensitivity analyses confirmed these findings. Conclusions PST delivered by nurses seems cost-effective in comparison with UC. However, these results should be interpreted with caution, since the difference in total costs was mainly caused by 3 outliers with extremely high indirect costs in the UC group. Trial registration Nederlands Trial Register ISRCTN51021015 PMID:23052105

  20. Effectiveness of a worksite social & physical environment intervention on need for recovery, physical activity and relaxation; results of a randomized controlled trial.

    PubMed

    Coffeng, Jennifer K; Boot, Cécile R L; Duijts, Saskia F A; Twisk, Jos W R; van Mechelen, Willem; Hendriksen, Ingrid J M

    2014-01-01

    intensity of the intervention (for example weekly GMI-sessions), providing physical activity opportunities and exercise schemes, and by more drastic environment interventions (restructuring entire department floor). Nederlands Trial Register NTR2553.

  1. In search of links between social capital, mental health and sociotherapy: a longitudinal study in Rwanda.

    PubMed

    Verduin, Femke; Smid, Geert E; Wind, Tim R; Scholte, Willem F

    2014-11-01

    interventions that effectively promote recovery in war-affected populations. Nederlands Trial Register 1120. Copyright © 2014 Elsevier Ltd. All rights reserved.

  2. Effectiveness of a cognitive-behavioral therapy (CBT) manualized program for clinically anxious children: study protocol of a randomized controlled trial.

    PubMed

    Jansen, Mélou; van Doorn, Marleen M E M; Lichtwarck-Aschoff, Anna; Kuijpers, Rowella C W M; Theunissen, Huub; Korte, Mirjam; van Rossum, José; Wauben, Annemiek; Granic, Isabela

    2012-03-12

    the potential to make treatment in these community settings shorter, more efficient and therefore cost-effective. Nederlands Trial Register NTR2967.

  3. Effectiveness and underlying mechanisms of a group-based cognitive behavioural therapy-based indicative prevention program for children with elevated anxiety levels.

    PubMed

    van Starrenburg, Manon L A; Kuijpers, Rowella C W M; Hutschemaekers, Giel J M; Engels, Rutger C M E

    2013-07-05

    would be easily implemented on a large scale. Nederlands Trial Register NTR3818.

  4. Cyclic volatile methylsiloxanes in human blood as markers for ruptured silicone gel-filled breast implants.

    PubMed

    Rosendahl, Pia; Hippler, Joerg; Schmitz, Oliver J; Hoffmann, Oliver; Rusch, Peter

    2016-05-01

    The replacement of medical-grade silicone with industrial-grade silicone material in some silicone gel-filled breast implants (SBI) manufactured by Poly Implant Prothèse and Rofil Medical Nederland B.V., reported in 2010, which resulted in a higher rupture tendency of these SBI, demonstrates the need for non-invasive, sensitive monitoring and screening methods. Therefore a sensitive method based on large volume injection-gas chromatography coupled to mass spectrometry (LVI-GC/MS) was developed to determine octamethylcyclotetrasiloxane (D4), decamethylcyclopentasiloxane (D5), and dodecamethylcyclo-hexasiloxane (D6) in blood samples from women with intact (n = 13) and ruptured SBI (n = 11). With dichloromethane extraction, sample cooling during preparation, and analysis extraction efficiencies up to 100 % and limits of detection of 0.03-0.05 ng D4-D6/g blood were achieved. Blood samples from women with SBI were investigated. In contrast to women with intact SBI, in blood from women with ruptured SBI higher D4 and D6 concentrations up to 0.57 ng D4/g blood and 0.16 ng D6/g blood were detected. With concentrations above 0.18 D4 ng/blood and 0.10 ng D6/g blood as significant criteria for ruptured SBI, this developed analytical preoperative diagnostic method shows a significant increase of the recognition rate. Finally a higher precision (error rate 17%) than the commonly used clinical diagnostic method, mamma sonography (error rate 46%), was achieved.

  5. Splint: the efficacy of orthotic management in rest to prevent equinus in children with cerebral palsy, a randomised controlled trial

    PubMed Central

    2012-01-01

    Background Range of motion deficits of the lower extremity occur in about the half of the children with spastic cerebral palsy (CP). Over time, these impairments can cause joint deformities and deviations in the children's gait pattern, leading to limitations in moblity. Preventing a loss of range of motion is important in order to reduce secondary activity limitations and joint deformities. Sustained muscle stretch, imposed by orthotic management in rest, might be an effective method of preventing a decrease in range of motion. However, no controlled study has been performed. Methods A single blind randomised controlled trial will be performed in 66 children with spastic CP, divided over three groups with each 22 participants. Two groups will be treated for 1 year with orthoses to prevent a decrease in range of motion in the ankle (either with static or dynamic knee-ankle-foot-orthoses) and a third group will be included as a control group and will receive usual care (physical therapy, manual stretching). Measurements will be performed at baseline and at 3, 6, 9 and 12 months after treatment allocation. The primary outcome measure will be ankle dorsiflexion at full knee extension, measured with a custom designed hand held dynamometer. Secondary outcome measures will be i) ankle and knee flexion during gait and ii) gross motor function. Furthermore, to gain more insight in the working mechanism of the orthotic management in rest, morphological parameters like achilles tendon length, muscle belly length, muscle fascicle length, muscle physiological cross sectional area length and fascicle pennation angle will be measured in a subgroup of 18 participants using a 3D imaging technique. Discussion This randomised controlled trial will provide more insight into the efficacy of orthotic management in rest and the working mechanisms behind this treatment. The results of this study could lead to improved treatments. Trial Registration Number Nederlands Trial Register NTR

  6. Prognostic value of FLT3 mutations in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline monochemotherapy

    PubMed Central

    Barragán, Eva; Montesinos, Pau; Camos, Mireia; González, Marcos; Calasanz, Maria J.; Román-Gómez, José; Gómez-Casares, Maria T.; Ayala, Rosa; López, Javier; Fuster, Óscar; Colomer, Dolors; Chillón, Carmen; Larrayoz, María J.; Sánchez-Godoy, Pedro; González-Campos, José; Manso, Félix; Amador, Maria L.; Vellenga, Edo; Lowenberg, Bob; Sanz, Miguel A.

    2011-01-01

    Background Fms-like tyrosine kinase-3 (FLT3) gene mutations are frequent in acute promyelocytic leukemia but their prognostic value is not well established. Design and Methods We evaluated FLT3-internal tandem duplication and FLT3-D835 mutations in patients treated with all-trans retinoic acid and anthracycline-based chemotherapy enrolled in two subsequent trials of the Programa de Estudio y Tratamiento de las Hemopatías Malignas (PETHEMA) and Hemato-Oncologie voor Volwassenen Nederland (HOVON) groups between 1996 and 2005. Results FLT3-internal tandem duplication and FLT3-D835 mutation status was available for 306 (41%) and 213 (29%) patients, respectively. Sixty-eight (22%) and 20 (9%) patients had internal tandem duplication and D835 mutations, respectively. Internal tandem duplication was correlated with higher white blood cell and blast counts, lactate dehydrogenase, relapse-risk score, fever, hemorrhage, coagulopathy, BCR3 isoform, M3 variant subtype, and expression of CD2, CD34, human leukocyte antigen-DR, and CD11b surface antigens. The FLT3-D835 mutation was not significantly associated with any clinical or biological characteristic. Univariate analysis showed higher relapse and lower survival rates in patients with a FLT3-internal tandem duplication, while no impact was observed in relation to FLT3-D835. The prognostic value of the FLT3-internal tandem duplication was not retained in the multivariate analysis. Conclusions FLT3-internal tandem duplication mutations are associated with several hematologic features in acute promyelocytic leukemia, in particular with high white blood cell counts, but we were unable to demonstrate an independent prognostic value in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline-based regimens. PMID:21685470

  7. Qualitative Treatment-Subgroup Interactions in a Randomized Clinical Trial of Treatments for Adolescents with ADHD: Exploring What Cognitive-Behavioral Treatment Works for Whom

    PubMed Central

    Geurts, Hilde M.; Prins, Pier J. M.; Van Mechelen, Iven; Van der Oord, Saskia

    2016-01-01

    Objective This study explored qualitative treatment-subgroup interactions within data of a RCT with two cognitive behavioral treatments (CBT) for adolescents with ADHD: a planning-focused (PML) and a solution-focused CBT (SFT). Qualitative interactions imply that which treatment is best differs across subgroups of patients, and are therefore most relevant for personalized medicine. Methods Adolescents with ADHD (N = 159) received either PML or SFT. Pre-, post- and three-month follow-up data were gathered on parent-rated ADHD symptoms and planning problems. Pretreatment characteristics were explored as potential qualitative moderators of pretest to follow-up treatment effects, using an innovative analyses technique (QUINT; Dusseldorp & Van Mechelen, 2014). In addition, qualitative treatment-subgroup interactions for the therapeutic changes from pre- to posttest and from post- to follow-up test were investigated. Results For the entire time span from pretest to follow-up only a quantitative interaction was found, while from posttest to follow-up qualitative interactions were found: Adolescents with less depressive symptoms but more anxiety symptoms showed more improvement when receiving PML than SFT, while for other adolescents the effects of PML and SFT were comparable. Discussion Whereas subgroups in both treatments followed different trajectories, no subgroup was found for which SFT outperformed PML in terms of the global change in symptoms from pretest to three months after treatment. This implies that, based on this exploratory study, there is no need for personalized treatment allocation with regard to the CBTs under study for adolescents with ADHD. However, for a subgroup with comorbid anxiety symptoms but low depression PML clearly appears the treatment of preference. Trial Registration Nederlands Trial Register NTR2142 PMID:26977602

  8. Ozone columns obtained by ground-based remote sensing in Kiev for Aura Ozone Measuring Instrument validation

    NASA Astrophysics Data System (ADS)

    Shavrina, A. V.; Pavlenko, Y. V.; Veles, A.; Syniavskyi, I.; Kroon, M.

    2007-12-01

    Ground-based observations with a Fourier transform spectrometer in the infrared region (FTIR) were performed in Kiev (Ukraine) during the time frames August-October 2005 and June-October 2006 within the Ozone Monitoring Instrument (OMI) validation project 2907 entitled "OMI validation by ground based remote sensing: ozone columns and profiles" in the frame of the international European Space Agency/Netherlands Agency for Aerospace Programmes/Royal Dutch Meteorological Institute OMI Announcement of Opportunity effort. Ozone column data for 2005 were obtained by modeling the ozone spectral band at 9.6 μm with the radiative transfer code MODTRAN3.5. Our total ozone column values were found to be lower than OMI Differential Optical Absorption Spectroscopy (DOAS) total ozone column data by 8-10 Dobson units (DU, 1 DU = 0.001 atm cm) on average, while our observations have a relatively small standard error of about 2 DU. Improved modeling of the ozone spectral band, now based on HITRAN-2004 spectral data as calculated by us, moves our results toward better agreement with the OMI DOAS total ozone column data. The observations made during 2006 with a modernized FTIR spectrometer and higher signal-to-noise ratio were simulated by the MODTRAN4 model computations. For ozone column estimates the Aqua Atmospheric Infrared Sounder satellite water vapor and temperature profiles were combined with the Aura Microwave Limb Sounder stratospheric ozone profiles and Tropospheric Emission Monitoring Internet Service-Koninklijk Nederlands Meteorologisch Instituut climatological profiles to create a priori input files for spectral modeling. The MODTRAN4 estimates of ozone columns from the 2006 observations compare rather well with the OMI total ozone column data: standard errors are of 1.11 DU and 0.68 DU, standard deviation are of 8.77 DU and 5.37 DU for OMI DOAS and OMI Total Ozone Mapping Spectrometer, respectively.

  9. Quantifying and Reducing Uncertainties in Estimating OMI Tropospheric Column NO2 Trend over The United States

    NASA Astrophysics Data System (ADS)

    Smeltzer, C. D.; Wang, Y.; Boersma, F.; Celarier, E. A.; Bucsela, E. J.

    2013-12-01

    We investigate the effects of retrieval radiation schemes and parameters on trend analysis using tropospheric nitrogen dioxide (NO2) vertical column density (VCD) measurements over the United States. Ozone Monitoring Instrument (OMI) observations from 2005 through 2012 are used in this analysis. We investigated two radiation schemes, provided by National Aeronautics and Space Administration (NASA TOMRAD) and Koninklijk Nederlands Meteorologisch Instituut (KNMI DAK). In addition, we analyzed trend dependence on radiation parameters, including surface albedo and viewing geometry. The cross-track mean VCD average difference is 10-15% between the two radiation schemes in 2005. As the OMI anomaly developed and progressively worsens, the difference between the two schemes becomes larger. Furthermore, applying surface albedo measurements from the Moderate Resolution Imaging Spectroradiometer (MODIS) leads to increases of estimated NO2 VCD trends over high-emission regions. We find that the uncertainties of OMI-derived NO2 VCD trends can be reduced by up to a factor of 3 by selecting OMI cross-track rows on the basis of their performance over the ocean [see abstract figure]. Comparison of OMI tropospheric VCD trends to those estimated based on the EPA surface NO2 observations indicate using MODIS surface albedo data and a more narrow selection of OMI cross-track rows greatly improves the agreement of estimated trends between satellite and surface data. This figure shows the reduction of uncertainty in OMI NO2 trend by selecting OMI cross-track rows based on the performance over the ocean. With this technique, uncertainties within the seasonal trend may be reduced by a factor of 3 or more (blue) compared with only removing the anomalous rows: considering OMI cross-track rows 4-24 (red).

  10. The EUMETSAT ocean and sea ice SAF (OSI SAF) : Overview on the project and the products

    NASA Astrophysics Data System (ADS)

    Guevel, Guenole

    The EUMETSAT OSI SAF (www.osi-saf.org) was created in 1997 as an answer to requirements for a comprehensive information derived from meteorological satellites at the ocean-atmosphere interface. The OSI SAF consortium is constituted of Météo-France as leading entity, and Met.no (Norske ee Meteorologiske Institutt), DMI (Danish Meteorological Institute), SMHI (Swedish Meteorolog-ical and Hydrological Institute), KNMI (Koninklijk Nederlands Meteorologisch Instituut) and IFREMER (Institut Français de Recherche pour l'Exploitation de la MER) as co-operating c entities. The two previous phases of the EUMETSAT Ocean and Sea Ice Satellite Application Facility (OSI SAF), the Development phase (1997-2002) and the IOP (initial Operations Phase, 2002-2007) met the main target which was to develop, validate and then produce operationally quality controlled satellite-derived products related to four key parameters of the sea surface (Sea Surface Temperature, Radiative Fluxes, Sea Ice, Wind) over various geographical coverage from regional to global. These products are currently available in near real time both through EUMETCAST and local FTP servers, and off line from local archive. Archiving at EUMETSAT Data Center is also being implemented. The current phase of the EUMETSAT OSI SAF, the CDOP (Continuous Development and Operations Phase, 2007-2012) has taken into account new requirements expressed in particular in the context of GODAE, GHRSST and GCOS at international level, and GMES (through MyOcean) at European level, with in particular a strong need for increasing the temporal and geographical resolution of the products and user friendly interfaces allowing access to high level allowing flexible extraction An overview on the OSI SAF project and its current and future production in the time frame of the CDOP will be presented, as well as first glance on the following phase, the CDOP-2, that will cover 2012 to 2017.

  11. Long Term Outcomes of a Geriatric Liaison Intervention in Frail Elderly Cancer Patients

    PubMed Central

    Hempenius, Liesbeth; Slaets, Joris P. J.; van Asselt, Dieneke; de Bock, Truuske H.; Wiggers, Theo; van Leeuwen, Barbara L.

    2016-01-01

    Background The aim of this study was to evaluate the long term effects after discharge of a hospital-based geriatric liaison intervention to prevent postoperative delirium in frail elderly cancer patients treated with an elective surgical procedure for a solid tumour. In addition, the effect of a postoperative delirium on long term outcomes was examined. Methods A three month follow-up was performed in participants of the Liaison Intervention in Frail Elderly study, a multicentre, prospective, randomized, controlled trial. Patients were randomized to standard treatment or a geriatric liaison intervention. The intervention consisted of a preoperative geriatric consultation, an individual treatment plan targeted at risk factors for delirium and daily visits by a geriatric nurse during the hospital stay. The long term outcomes included: mortality, rehospitalisation, Activities of Daily Living (ADL) functioning, return to the independent pre-operative living situation, use of supportive care, cognitive functioning and health related quality of life. Results Data of 260 patients (intervention n = 127, Control n = 133) were analysed. There were no differences between the intervention group and usual-care group for any of the outcomes three months after discharge. The presence of postoperative delirium was associated with: an increased risk of decline in ADL functioning (OR: 2.65, 95% CI: 1.02–6.88), an increased use of supportive assistance (OR: 2.45, 95% CI: 1.02–5.87) and a decreased chance to return to the independent preoperative living situation (OR: 0.18, 95% CI: 0.07–0.49). Conclusions A hospital-based geriatric liaison intervention for the prevention of postoperative delirium in frail elderly cancer patients undergoing elective surgery for a solid tumour did not improve outcomes 3 months after discharge from hospital. The negative effect of a postoperative delirium on late outcome was confirmed. Trial Registration Nederlands Trial Register, Trial ID NTR 823

  12. [Drug-promoting advertisements in the Dutch Journal of Medicine and Pharmaceutical Weekly: not always evidence based].

    PubMed

    van Eeden, Annelies E; Roach, Rachel E J; Halbesma, Nynke; Dekker, Friedo W

    2012-01-01

    To determine and compare the foundation of claims in drug-promoting advertisements in a Dutch journal for physicians and a Dutch journal for pharmacists. A cross-sectional study. We included all the drug-promoting advertisements referring to a randomized controlled trial (RCT) we could find on Medline from 2 volumes of the Dutch Journal of Medicine (Nederlands Tijdschrift voor Geneeskunde; NTvG) and the (also Dutch) Pharmaceutical Weekly (Pharmaceutisch Weekblad; PW). The validity of the advertisements (n = 54) and the methodological quality of the referenced RCTs (n = 150) were independently scored by 250 medical students using 2 standardised questionnaires. The advertisements' sources were concealed from the students. Per journal, the percentage of drug-promoting advertisements having a valid claim and the percentage of high-quality RCT references were determined. Average scores on quality and validity were compared between the 2 journals. On a scale of 0-18 points, the mean quality scores of the RCTs differed 0.3 (95% CI: -0.1-0.7) between the NTvG (score: 14.8; SD: 2.2) and the PW (score: 14.5; SD: 2.6). The difference between the validity scores of drug-promoting advertisements in the NTvG (score: 5.8; SD: 3.3) and the PW (score: 5.6; SD: 3.6) was 0.3 (95% CI: -0.3-0.9) on a scale of 0-10 points. For both journals, an average of 15% of drug-promoting advertisements was valid (defined as a validity score of > 8 points); 35% of the RCTs referred to was of good methodological quality (defined as a quality score of > 16 points). The substantiation of many claims in drug-promoting advertisements in the NTvG and the PW was mediocre. There was no difference between the 2 journals.

  13. Web-based self-management with and without coaching for type 2 diabetes patients in primary care: design of a randomized controlled trial

    PubMed Central

    2013-01-01

    Background Self-management is recognized as the cornerstone of overall diabetes management. Web-based self-management programs have the potential of supporting type 2 diabetes patients with managing their diabetes and reducing the workload for the care provider, where the addition of online coaching could improve patient motivation and reduce program attrition. This study aims to test the hypothesis that a web-based self-management program with coaching will prove more effective on improving patient self-management behavior and clinical outcome measures than a web-based self-management program without coaching. Methods The effects of a web-based self-management program with and without coaching will be tested with a nested randomized controlled trial within a healthcare group in the Netherlands. In one year 220 type 2 diabetes patients will be randomized into an intervention group (n = 110) or a control group (n = 110). The control group will receive only the online self-management program. The intervention group will receive the online self-management program and additional online coaching. Participants will be followed for one year, with follow-up measurements at 6 and 12 months. Discussion The intervention being tested is set to support type 2 diabetes patients with their diabetes self-management and is expected to have beneficial effects on self-care activities, well being and clinical outcomes. When proven effective this self-management support program could be offered to other health care groups and their type 2 diabetes patients in the Netherlands. Trial registration Nederlands Trial Register NTR4064 PMID:24238104

  14. Subtypes of borderline personality disorder patients: a cluster-analytic approach.

    PubMed

    Smits, Maaike L; Feenstra, Dine J; Bales, Dawn L; de Vos, Jasmijn; Lucas, Zwaan; Verheul, Roel; Luyten, Patrick

    2017-01-01

    Nederlands Trial Register, no. NTR2292.

  15. Primary prevention of overweight in preschool children, the BeeBOFT study (breastfeeding, breakfast daily, outside playing, few sweet drinks, less TV viewing): design of a cluster randomized controlled trial.

    PubMed

    Raat, Hein; Struijk, Mirjam K; Remmers, Teun; Vlasblom, Eline; van Grieken, Amy; Broeren, Suzanne M L; te Velde, Saskia J; Beltman, Maaike; Boere-Boonekamp, Magda M; L'Hoir, Monique P

    2013-10-19

    care. Nederlands Trial Register NTR1831.

  16. The effects of low-intensity narrow-band blue-light treatment compared to bright white-light treatment in sub-syndromal seasonal affective disorder.

    PubMed

    Meesters, Ybe; Winthorst, Wim H; Duijzer, Wianne B; Hommes, Vanja

    2016-02-18

    The discovery of a novel photoreceptor in the retinal ganglion cells with a highest sensitivity of 470-490 nm blue light has led to research on the effects of short-wavelength light in humans. Several studies have explored the efficacy of monochromatic blue or blue-enriched light in the treatment of SAD. In this study, a comparison has been made between the effects of broad-wavelength light without ultraviolet (UV) wavelengths compared to narrow-band blue light in the treatment of sub-syndromal seasonal affective disorder (Sub-SAD). In a 15-day design, 48 participants suffering from Sub-SAD completed 20-minute sessions of light treatment on five consecutive days. 22 participants were given bright white-light treatment (BLT, broad-wavelength light without UV 10 000 lux, irradiance 31.7 Watt/m(2)) and 26 participants received narrow-band blue light (BLUE, 100 lux, irradiance 1.0 Watt/m(2)). All participants completed daily and weekly questionnaires concerning mood, activation, sleep quality, sleepiness and energy. Also, mood and energy levels were assessed by means of the SIGH-SAD, the primary outcome measure. On day 15, SIGH-SAD ratings were significantly lower than on day 1 (BLT 54.8 %, effect size 1.7 and BLUE 50.7 %, effect size 1.9). No statistically significant differences were found on the main outcome measures. Light treatment is an effective treatment for Sub-SAD. The use of narrow-band blue-light treatment is equally effective as bright white-light treatment. This study was registered in the Dutch Trial Register (Nederlands Trial Register TC =  4342 ) (20-12-2013).

  17. ACE Inhibitors Potently Reduce Vascular Inflammation, Results of an Open Proof-Of-Concept Study in the Abdominal Aortic Aneurysm

    PubMed Central

    Kortekaas, Kim E.; Meijer, C. Arnoud; Hinnen, Jan Willem; Dalman, Ronald L.; Xu, Baohui; Hamming, Jaap F.; Lindeman, Jan H.

    2014-01-01

    Background Independent of their blood pressure lowering effect, ACE inhibitors are thought to reduce vascular inflammation. The clinical relevance of this effect is unclear with the current knowledge. Abdominal aortic aneurysms (AAA) are characterized by a broad, non-specific inflammatory response, and thus provide a clinical platform to evaluate the anti-inflammatory potential of ACE inhibitors. Methods and Results Eleven patients scheduled for open AAA repair received ramipril (5 mg/day) during 2–4 weeks preceding surgery. Aortic wall samples were collected during surgery, and compared to matched samples obtained from a biobank. An anti-inflammatory potential was evaluated in a comprehensive analysis that included immunohistochemistry, mRNA and protein analysis. A putative effect of ACE inhibitors on AAA growth was tested separately by comparing 18-month growth rate of patients on ACE inhibitors (n = 82) and those not taking ACE inhibitors (n = 204). Ramipril reduces mRNA expression of multiple pro-inflammatory cytokines such as IL-1β, IL-6, IL-8, TNF -α, Interferon-, and MCP-1, as well as aortic wall IL-8 and MCP-1 (P = 0.017 and 0.008, respectively) protein content. The is followed by clear effects on cell activation that included a shift towards anti-inflammatory macrophage (M2) subtype. Evaluation of data from the PHAST cohort did not indicate an effect of ACE inhibitors on 18-month aneurysm progression (mean difference at 18 months: −0.24 mm (95% CI: −0.90–0.45, P = NS). Conclusions ACE inhibition quenches multiple aspects of vascular inflammation in AAA. However, this does not translate into reduced aneurysm growth. Trial Registration Nederlands Trial Register 1345. PMID:25474105

  18. The effectiveness of lifestyle triple P in the Netherlands: a randomized controlled trial.

    PubMed

    Gerards, Sanne M P L; Dagnelie, Pieter C; Gubbels, Jessica S; van Buuren, Stef; Hamers, Femke J M; Jansen, Maria W J; van der Goot, Odilia H M; de Vries, Nanne K; Sanders, Matthew R; Kremers, Stef P J

    2015-01-01

    behaviors and parenting measures, no effects were visible on children's body composition or objectively measured physical activity. Several adjustments of the intervention content are recommended, for example including a booster session. Nederlands Trial Register NTR 2555.

  19. A goal management intervention for polyarthritis patients: rationale and design of a randomized controlled trial

    PubMed Central

    2013-01-01

    . Trial registration Nederlands Trial Register = NTR3606, registration date 11-09-2012. PMID:23941633

  20. Additional value of computer assisted semen analysis (CASA) compared to conventional motility assessments in pig artificial insemination.

    PubMed

    Broekhuijse, M L W J; Soštarić, E; Feitsma, H; Gadella, B M

    2011-11-01

    In order to obtain a more standardised semen motility evaluation, Varkens KI Nederland has introduced a computer assisted semen analysis (CASA) system in all their pig AI laboratories. The repeatability of CASA was enhanced by standardising for: 1) an optimal sample temperature (39 °C); 2) an optimal dilution factor; 3) optimal mixing of semen and dilution buffer by using mechanical mixing; 4) the slide chamber depth, and together with the previous points; 5) the optimal training of technicians working with the CASA system; and 6) the use of a standard operating procedure (SOP). Once laboratory technicians were trained in using this SOP, they achieved a coefficient of variation of < 5% which was superior to the variation found when the SOP was not strictly used. Microscopic semen motility assessments by eye were subjective and not comparable to the data obtained by standardised CASA. CASA results are preferable as accurate continuous motility dates are generated rather than discrimination motility percentage increments of 10% motility as with motility estimation by laboratory technicians. The higher variability of sperm motility found with CASA and the continuous motility values allow better analysis of the relationship between semen motility characteristics and fertilising capacity. The benefits of standardised CASA for AI is discussed both with respect to estimate the correct dilution factor of the ejaculate for the production of artificial insemination (AI) doses (critical for reducing the number of sperm per AI doses) and thus to get more reliable fertility data from these AI doses in return. Copyright © 2011 Elsevier Inc. All rights reserved.

  1. Effects of High-Intensity Interval Training versus Continuous Training on Physical Fitness, Cardiovascular Function and Quality of Life in Heart Failure Patients

    PubMed Central

    Benda, Nathalie M. M.; Seeger, Joost P. H.; Stevens, Guus G. C. F.; Hijmans-Kersten, Bregina T. P.; van Dijk, Arie P. J.; Bellersen, Louise; Lamfers, Evert J. P.; Hopman, Maria T. E.; Thijssen, Dick H. J.

    2015-01-01

    Introduction Physical fitness is an important prognostic factor in heart failure (HF). To improve fitness, different types of exercise have been explored, with recent focus on high-intensity interval training (HIT). We comprehensively compared effects of HIT versus continuous training (CT) in HF patients NYHA II-III on physical fitness, cardiovascular function and structure, and quality of life, and hypothesize that HIT leads to superior improvements compared to CT. Methods Twenty HF patients (male:female 19:1, 64±8 yrs, ejection fraction 38±6%) were allocated to 12-weeks of HIT (10*1-minute at 90% maximal workload—alternated by 2.5 minutes at 30% maximal workload) or CT (30 minutes at 60–75% of maximal workload). Before and after intervention, we examined physical fitness (incremental cycling test), cardiac function and structure (echocardiography), vascular function and structure (ultrasound) and quality of life (SF-36, Minnesota living with HF questionnaire (MLHFQ)). Results Training improved maximal workload, peak oxygen uptake (VO2peak) related to the predicted VO2peak, oxygen uptake at the anaerobic threshold, and maximal oxygen pulse (all P<0.05), whilst no differences were present between HIT and CT (N.S.). We found no major changes in resting cardiovascular function and structure. SF-36 physical function score improved after training (P<0.05), whilst SF-36 total score and MLHFQ did not change after training (N.S.). Conclusion Training induced significant improvements in parameters of physical fitness, although no evidence for superiority of HIT over CT was demonstrated. No major effect of training was found on cardiovascular structure and function or quality of life in HF patients NYHA II-III. Trial Registration Nederlands Trial Register NTR3671 PMID:26517867

  2. Splint: the efficacy of orthotic management in rest to prevent equinus in children with cerebral palsy, a randomised controlled trial.

    PubMed

    Maas, Josina C; Dallmeijer, Annet J; Huijing, Peter A; Brunstrom-Hernandez, Janice E; van Kampen, Petra J; Jaspers, Richard T; Becher, Jules G

    2012-03-26

    Range of motion deficits of the lower extremity occur in about the half of the children with spastic cerebral palsy (CP). Over time, these impairments can cause joint deformities and deviations in the children's gait pattern, leading to limitations in moblity. Preventing a loss of range of motion is important in order to reduce secondary activity limitations and joint deformities. Sustained muscle stretch, imposed by orthotic management in rest, might be an effective method of preventing a decrease in range of motion. However, no controlled study has been performed. A single blind randomised controlled trial will be performed in 66 children with spastic CP, divided over three groups with each 22 participants. Two groups will be treated for 1 year with orthoses to prevent a decrease in range of motion in the ankle (either with static or dynamic knee-ankle-foot-orthoses) and a third group will be included as a control group and will receive usual care (physical therapy, manual stretching). Measurements will be performed at baseline and at 3, 6, 9 and 12 months after treatment allocation. The primary outcome measure will be ankle dorsiflexion at full knee extension, measured with a custom designed hand held dynamometer. Secondary outcome measures will be i) ankle and knee flexion during gait and ii) gross motor function. Furthermore, to gain more insight in the working mechanism of the orthotic management in rest, morphological parameters like achilles tendon length, muscle belly length, muscle fascicle length, muscle physiological cross sectional area length and fascicle pennation angle will be measured in a subgroup of 18 participants using a 3D imaging technique. This randomised controlled trial will provide more insight into the efficacy of orthotic management in rest and the working mechanisms behind this treatment. The results of this study could lead to improved treatments. Nederlands Trial Register NTR2091.

  3. The effects of Psychotropic drugs On Developing brain (ePOD) study: methods and design

    PubMed Central

    2014-01-01

    Background Animal studies have shown that methylphenidate (MPH) and fluoxetine (FLX) have different effects on dopaminergic and serotonergic system in the developing brain compared to the developed brain. The effects of Psychotropic drugs On the Developing brain (ePOD) study is a combination of different approaches to determine whether there are related findings in humans. Methods/Design Animal studies were carried out to investigate age-related effects of psychotropic drugs and to validate new neuroimaging techniques. In addition, we set up two double-blind placebo controlled clinical trials with MPH in 50 boys (10–12 years) and 50 young men (23–40 years) suffering from ADHD (ePOD-MPH) and with FLX in 40 girls (12–14 years) and 40 young women (23–40 years) suffering from depression and anxiety disorders (ePOD-SSRI). Trial registration numbers are: Nederlands Trial Register NTR3103 and NTR2111. A cross-sectional cohort study on age-related effects of these psychotropic medications in patients who have been treated previously with MPH or FLX (ePOD-Pharmo) is also ongoing. The effects of psychotropic drugs on the developing brain are studied using neuroimaging techniques together with neuropsychological and psychiatric assessments of cognition, behavior and emotion. All assessments take place before, during (only in case of MPH) and after chronic treatment. Discussion The combined results of these approaches will provide new insight into the modulating effect of MPH and FLX on brain development. PMID:24552282

  4. Effect of rTMS on brain activation in schizophrenia with negative symptoms: A proof-of-principle study.

    PubMed

    Dlabac-de Lange, Jozarni J; Liemburg, Edith J; Bais, Leonie; Renken, Remco J; Knegtering, Henderikus; Aleman, André

    2015-10-01

    Prefrontal cortical dysfunction is frequently reported in schizophrenia and is thought to underlie negative symptoms of schizophrenia. Repetitive Transcranial Magnetic Stimulation (rTMS) can modulate neuronal activity and has been shown to improve negative symptoms in patients with schizophrenia, but the underlying neural mechanism is unknown. To examine whether 3weeks of 10Hz rTMS treatment of the bilateral dorsolateral prefrontal cortex (DLPFC) would improve frontal brain activation in patients with negative symptoms of schizophrenia, as measured by functional magnetic resonance imaging (fMRI) during the Tower of London (ToL) task. 24 patients with the diagnosis of schizophrenia with moderate to severe negative symptoms (Positive and Negative Syndrome Scale (PANSS) negative subscale≥15) participated. Patients were randomized to a 3-week (15day) course of active or sham rTMS. All patients performed the ToL task during fMRI scanning both pre-treatment and post-treatment. Differences in brain activation between the two groups were compared non-parametrically. After rTMS treatment, brain activity in the active group increased in the right DLPFC and the right medial frontal gyrus as compared to the sham group. In addition, the groups significantly differed with regard to activation change in the left posterior cingulate, with decreased activation in the active and increased activation in the sham group. Treatment with rTMS over the DLPFC may have the potential for increasing task-related activation in frontal areas in patients with schizophrenia. Effects of different rTMS parameters and fMRI tasks targeting relevant brain circuitry deserve further investigation. Nederlands Trial Register, registration number: NTR1261. Copyright © 2015 Elsevier B.V. All rights reserved.

  5. A goal management intervention for polyarthritis patients: rationale and design of a randomized controlled trial.

    PubMed

    Arends, Roos Y; Bode, Christina; Taal, Erik; Van de Laar, Mart A F J

    2013-08-13

    A health promotion intervention was developed for inflammatory arthritis patients, based on goal management. Elevated levels of depression and anxiety symptoms, which indicate maladjustment, are found in such patients. Other indicators of adaptation to chronic disease are positive affect, purpose in life and social participation. The new intervention focuses on to improving adaptation by increasing psychological and social well-being and decreasing symptoms of affective disorders. Content includes how patients can cope with activities and life goals that are threatened or have become impossible to attain due to arthritis. The four goal management strategies used are: goal maintenance, goal adjustment, goal disengagement and reengagement. Ability to use various goal management strategies, coping versatility and self-efficacy are hypothesized to mediate the intervention's effect on primary and secondary outcomes. The primary outcome is depressive symptoms. Secondary outcomes are anxiety symptoms, positive affect, purpose in life, social participation, pain, fatigue and physical functioning. A cost-effectiveness analysis and stakeholders' analysis are planned. The protocol-based psycho-educational program consists of six group-based meetings and homework assignments, led by a trained nurse. Participants are introduced to goal management strategies and learn to use these strategies to cope with threatened personal goals. Four general hospitals participate in a randomized controlled trial with one intervention group and a waiting list control condition. The purpose of this study is to evaluate the effectiveness of a goal management intervention. The study has a holistic focus as both the absence of psychological distress and presence of well-being are assessed. In the intervention, applicable goal management competencies are learned that assist people in their choice of behaviors to sustain and enhance their quality of life. Nederlands Trial Register = NTR3606

  6. Neurocinematography in Pre-World War II Netherlands: The Magnus-Rademaker Collection.

    PubMed

    Koehler, Peter J; Lameris, Bregt; Hielscher, Eva

    2016-01-01

    Historical films made by neuroscientists have shown up in several countries during past years. Although originally supposed to have been lost, we recently found a collection of films produced between 1909 and 1940 by Rudolf Magnus (1873-1927), professor of pharmacology (Utrecht) and his student Gysbertus Rademaker (1887-1957), professor of physiology (1928, succeeding Willem Einthoven) and neurology (1945, both in Leiden). Both collections deal with the physiology of body posture by the equilibrium of reflex musculature contractions for which experimental studies were done with animals (labyrinthectomies, cerebellectomies, and brainstem sections) and observations on patients. The films demonstrate the results of these studies. Moreover, there are films with babies showing tonic neck reflexes and moving images capturing adults with cerebellar symptoms following cerebellectomies for tumors and several other conditions. Magnus' studies resulted in his well-known Körperstellung (1924, "Body Posture") and Rademaker's research in his Das Stehen (1931, "Standing"). The films probably had an educative and scientific purpose. Magnus demonstrated his films at congresses, including the Eighth International Congress of Physiologists (Vienna, 1910) and Rademaker screened his moving images at meetings of the Amsterdam Neurologists Society (at several occasions as reflected in the Winkler-Monakow correspondence and the Nederlands Tijdschrift voor Geneeskunde). Next to these purposes, the films were used to analyze movement and a series of images from the films were published in articles and books. The films are important historical sources that provide a portrait of the pre-World War II era in neuroscience, partly answering questions on how physicians dealt with patients and researchers with their laboratory animals. Moreover, the films confirm that cinematography was an important scientific tool in neuroscience research.

  7. Differences between left- and right-sided neglect revisited: A large cohort study across multiple domains.

    PubMed

    Ten Brink, Antonia F; Verwer, Jurre H; Biesbroek, J Matthijs; Visser-Meily, Johanna M A; Nijboer, Tanja C W

    2017-09-01

    Unilateral spatial neglect (USN) is a syndrome that can occur after right- and left-hemisphere damage. It is generally accepted that left-sided USN is more severe than right-sided USN. Evidence for such a difference in other domains is lacking. Primary aims were to compare frequency, severity, region specificity, cognition, physical functioning, and physical independence between left and right USN. Secondary aims were to compare lesion characteristics. A total of 335 stroke patients admitted for inpatient rehabilitation were included. The severity of the lateralized attentional deficit was measured with a shape cancellation and line bisection test (in peripersonal and extrapersonal space) and the Catherine Bergego scale. The Mini-Mental State Examination, Stichting Afasie Nederland score, search organization (i.e., best R and intersections rate), Motricity Index, balance, mobility, and self-care were assessed. Measures were statistically compared between left, right, and no USN patients. Lesion overlay plots were compared with lesion subtraction analyses. Left USN (15.82%) was more frequent than right USN (9.25%). Demographic and stroke characteristics were comparable between groups. The lateralized attentional deficit was most severe in left USN. USN in both peripersonal and extrapersonal space was more frequently left-sided in nature. Search efficiency was lower in left USN. Balance was poorer in right USN. No differences between left and right USN were found for cognitive ability, communication, motor strength, mobility, and self-care. Most patients with left USN had right-hemispheric lesions, whereas patients with right USN could have lesions in either the left or the right hemisphere. To conclude, left and right USN are both common after stroke. Although the lateralized attention deficit is worse in left than in right USN, consequences at the level of physical functioning and physical independence are largely comparable. From a clinical perspective, it is

  8. Ethical acceptability of offering financial incentives for taking antipsychotic depot medication: patients' and clinicians' perspectives after a 12-month randomized controlled trial.

    PubMed

    Noordraven, Ernst L; Schermer, Maartje H N; Blanken, Peter; Mulder, Cornelis L; Wierdsma, André I

    2017-08-29

    , motivation and the preferred size and duration of the incentive. Nederlands Trial Register, number NTR2350 .

  9. Primary prevention of overweight in preschool children, the BeeBOFT study (breastfeeding, breakfast daily, outside playing, few sweet drinks, less TV viewing): design of a cluster randomized controlled trial

    PubMed Central

    2013-01-01

    development of overweight and obesity compared to usual care. Trial registration Nederlands Trial Register NTR1831. PMID:24138805

  10. Effectiveness of a Hospital-Based Work Support Intervention for Female Cancer Patients – A Multi-Centre Randomised Controlled Trial

    PubMed Central

    Tamminga, Sietske J.; Verbeek, Jos H. A. M.; Bos, Monique M. E. M.; Fons, Guus; Kitzen, Jos J. E. M.; Plaisier, Peter W.; Frings-Dresen, Monique H. W.; de Boer, Angela G. E. M.

    2013-01-01

    the intervention are useful and which elements need improvement. Trial Registration Nederlands Trial Register (NTR) 1658 PMID:23717406

  11. The Role of Catechol-O-Methyl Transferase Val(108/158)Met Polymorphism (rs4680) in the Effect of Green Tea on Resting Energy Expenditure and Fat Oxidation: A Pilot Study

    PubMed Central

    Hursel, Rick; Janssens, Pilou L. H. R.; Bouwman, Freek G.; Mariman, Edwin C.; Westerterp-Plantenga, Margriet S.

    2014-01-01

    and FATox after GT treatment. Trial Registration Nederlands Trial register NTR1918 PMID:25238062

  12. Influence of Intensified Supervision by Health Care Inspectorates on Online Patient Ratings of Hospitals: A Multilevel Study of More Than 43,000 Online Ratings

    PubMed Central

    Kleefstra, Sophia Martine; Borghans, Ine; Atsma, Femke; van de Belt, Tom H

    2016-01-01

    Background In the Netherlands, hospitals with quality or safety issues are put under intensified supervision by the Dutch Health Care Inspectorate, which involves frequent announced and unannounced site visits and other measures. Patient rating sites are an upcoming phenomenon in health care. Patient reviews might be influenced by perceived quality including the media coverage of health care providers when the health care inspectorate imposes intensified supervision, but no data are available to show how these are related. Objective The aim of this study was to investigate whether and how being under intensified supervision of the health care inspectorate influences online patient ratings of hospitals. Methods We performed a longitudinal study using data from the patient rating site Zorgkaart Nederland, from January 1, 2010 to December 31, 2015. We compared data of 7 hospitals under intensified supervision with a control group of 28 hospitals. The dataset contained 43,856 ratings. We performed a multilevel logistic regression analysis to account for clustering of ratings within hospitals. Fixed effects in our analysis were hospital type, time, and the period of intensified supervision. Random effect was the hospital. The outcome variable was the dichotomized rating score. Results The period of intensified supervision was associated with a low rating score for the hospitals compared with control group hospitals; both 1 year before intensified supervision (odds ratio, OR, 1.67, 95% CI 1.06-2.63) and 1 year after (OR 1.79, 95% CI 1.14-2.81) the differences are significant. For all periods, the odds on a low rating score for hospitals under intensified supervision are higher than for the control group hospitals, corrected for time. Time is also associated with low rating scores, with decreasing ORs over time since 2010. Conclusions Hospitals that are confronted with intensified supervision by the health care inspectorate have lower ratings on patient rating sites. The

  13. Website Use and Effects of Online Information About Tobacco Additives Among the Dutch General Population: A Randomized Controlled Trial

    PubMed Central

    Crutzen, Rik; Kienhuis, Anne S; Talhout, Reinskje; de Vries, Hein

    2017-01-01

    necessary to find out how online information can be used to effectively communication about the risks of tobacco additives. Trial Registration Nederlands Trial Register NTR4620; http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=4620 (Archived by WebCite at http://www.webcitation.org/6oW7w4Gnj) PMID:28292739

  14. Influence of Inter-Training Intervals on Intermanual Transfer Effects in Upper-Limb Prosthesis Training: A Randomized Pre-Posttest Study.

    PubMed

    Romkema, Sietske; Bongers, Raoul M; van der Sluis, Corry K

    2015-01-01

    . Nederlands Trial Register NTR3888.

  15. Medical Advice for Sick-reported Students (MASS) in intermediate vocational education schools: design of a controlled before-and-after study.

    PubMed

    Van der Vlis, Madelon K; Lugtenberg, Marjolein; Vanneste, Yvonne T M; Berends, Wenda; Mulder, Wico; Bannink, Rienke; Van Grieken, Amy; Raat, Hein; de Kroon, Marlou L A

    2017-06-29

    is hypothesized that implementing the MASS intervention including a referral to a YHC professional on indication, will result in a lower level of medical absenteeism and a lower level of school drop outs among intermediate vocational education students compared to students receiving usual care. The study will provide insight in the effectiveness of the intervention as well as in factors moderating the intervention's effectiveness. Nederlands Trial Register NTR5556. Date of clinical trial registration: 29-Oct-2015.

  16. Cost-effectiveness of pemetrexed in combination with cisplatin as first line treatment for patients with advanced non-squamous non-small-cell lung cancer in Spain.

    PubMed

    González García, Jonathan; Gutiérrez Nicolás, Fernando; Nazco Casariego, Gloria Julia; Valcárcel Nazco, Cristina; Batista López, Jose Norberto; Oramas Rodríguez, Juana

    2017-01-01

    Lung cancer is the third most frequent neoplastic tumour in Spain, with around 27 000 new cases diagnosed per year; 80-95% of these are non-small-cell cancer (NSCLC), and the majority of cases are diagnosed in advanced stages of the disease, and for this reason it is one of the oncologic conditions with higher mortality rates (21.4% mean survival at 5 years). The main treatment regimens used for first-line treatment of NSCLC are: cisplatin/pemetrexed (cis/pem), cisplatin/gemcitabine/ bevacizumab (cis/gem/bev), and carboplatin/paclitaxel/ bevacizumab (carb/pac/bev). The objective of this study was to evaluate the cost-effectiveness ratio of antineoplastic 1st line NSCLC treatment regimens, from the point of view of hospital management. A cost-efficacy mathematical model was prepared, based on a decision tree. The efficacy variable was Progression Free Survival, obtained from the PARAMOUNT, AVAIL and SAIL Phase III clinical trials. The study was conducted from the perspective of the hospital management, considering only the direct costs of drug acquisition. A deterministic sensitivity analysis was conducted to confirm the robustness of outcomes. The PFS obtained in clinical trials with cis/pem, cis/ gem/bev and carb/pac/bev was: 6.9, 6.7 and 6.2 months, respectively. Based on our model, the mean cost of treatment per patient for these regimens was: 19 942 €, 15 594 € and 36 095 €, respectively. The incremental cost-effectiveness ratio per month of additional PFS between cis/pem and cis/gem/bev was 19 303 €. Estimating a 30% reduction in acquisition costs for pemetrexed (Alimta®Eli Lilly Nederland B.V.), due to the forthcoming launch of generic medications, the cis/pem treatment would become the predominant alternative for 1st line treatment of NSCLC patients, by offering the best health results at a lower cost. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.

  17. Using an eHealth Intervention to Stimulate Health Behavior for the Prevention of Cognitive Decline in Dutch Adults: A Study Protocol for the Brain Aging Monitor

    PubMed Central

    2015-01-01

    and theories apply when they are used in a setting where no professional back-end is available. Trial Registration Nederlands Trial Register: NTR4144; http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=4144 (Archived by WebCite at http://www.webcitation.org/6cZzwZSg3) PMID:26554496

  18. Patients with unexplained physical symptoms have poorer quality of life and higher costs than other patient groups: a cross-sectional study on burden

    PubMed Central

    2013-01-01

    registration Nederlands Trial Register, NTR1609 PMID:24344899

  19. An economic evaluation of a video- and text-based computer-tailored intervention for smoking cessation: a cost-effectiveness and cost-utility analysis of a randomized controlled trial.

    PubMed

    Stanczyk, Nicola E; Smit, Eline S; Schulz, Daniela N; de Vries, Hein; Bolman, Catherine; Muris, Jean W M; Evers, Silvia M A A

    2014-01-01

    . Future studies with longer follow-up periods are needed to investigate whether cost-utility results regarding quality of life may change in the long run. Nederlands Trial Register NTR3102.

  20. Ingestion of Casein in a Milk Matrix Modulates Dietary Protein Digestion and Absorption Kinetics but Does Not Modulate Postprandial Muscle Protein Synthesis in Older Men.

    PubMed

    Churchward-Venne, Tyler A; Snijders, Tim; Linkens, Armand M A; Hamer, Henrike M; van Kranenburg, Janneau; van Loon, Luc J C

    2015-07-01

    percent excess) after Cas+Serum vs. Cas. Casein ingestion in a milk matrix delays protein digestion and absorption but does not modulate postprandial muscle protein synthesis when compared to the ingestion of micellar casein only in healthy older men. This trial was registered at Nederlands Trial Register as NTR4429. © 2015 American Society for Nutrition.

  1. Psychometric properties and longitudinal validation of the self-reporting questionnaire (SRQ-20) in a Rwandan community setting: a validation study.

    PubMed

    Scholte, Willem F; Verduin, Femke; van Lammeren, Anouk; Rutayisire, Theoneste; Kamperman, Astrid M

    2011-08-16

    the effect of a psychosocial intervention on mental health. Nederlands Trial Register NTR1120.

  2. The Effect on Mental Health of a Large Scale Psychosocial Intervention for Survivors of Mass Violence: A Quasi-Experimental Study in Rwanda

    PubMed Central

    Kamperman, Astrid M.; Rutayisire, Theoneste; Zwinderman, Aeilko H.; Stronks, Karien

    2011-01-01

    Registration Nederlands Trial Register 1120 PMID:21857908

  3. UVB phototherapy in an outpatient setting or at home: a pragmatic randomised single-blind trial designed to settle the discussion. The PLUTO study

    PubMed Central

    Koek, Mayke BG; Buskens, Erik; Steegmans, Paul HA; van Weelden, Huib; Bruijnzeel-Koomen, Carla AFM; Sigurdsson, Vigfús

    2006-01-01

    effectiveness, aspects such as quality of life and cost-effectiveness are also taken into consideration, this study will produce valuable evidence to either support or discourage prescription of home UVB phototherapy. Trial registration Current controlled trials/Nederlands Trial register: ISRCTN83025173. Clinicaltrials.gov: NCT00150930 PMID:16882343

  4. UVB phototherapy in an outpatient setting or at home: a pragmatic randomised single-blind trial designed to settle the discussion. The PLUTO study.

    PubMed

    Koek, Mayke B G; Buskens, Erik; Steegmans, Paul H A; van Weelden, Huib; Bruijnzeel-Koomen, Carla A F M; Sigurdsson, Vigfús

    2006-08-01

    quality of life and cost-effectiveness are also taken into consideration, this study will produce valuable evidence to either support or discourage prescription of home UVB phototherapy. Current controlled trials/Nederlands Trial register: ISRCTN83025173. Clinicaltrials.gov: NCT00150930.

  5. Effectiveness of a minimal psychological intervention to reduce mild to moderate depression and chronic fatigue in a working population: the design of a randomized controlled trial.

    PubMed

    Aelfers, Ed; Bosma, Hans; Houkes, Inge; van Eijk, Jacques Th M

    2013-02-12

    psychological problems. Additionally, long-term follow-up in a working population is time-consuming and continuously engages occupational health staff and administrative personnel to control the process of data gathering. However, if the intervention proves to be effective, occupational medicine will have a manageable option for treatment of workers who are at risk of loss of productivity or sickness absence. Nederlands Trialregister NTR3162.

  6. Effectiveness of a Worksite Social & Physical Environment Intervention on Need for Recovery, Physical Activity and Relaxation; Results of a Randomized Controlled Trial

    PubMed Central

    Coffeng, Jennifer K.; Boot, Cécile R. L.; Duijts, Saskia F. A.; Twisk, Jos W. R.; van Mechelen, Willem; Hendriksen, Ingrid J. M.

    2014-01-01

    itself could be improved by increasing the intensity of the intervention (for example weekly GMI-sessions), providing physical activity opportunities and exercise schemes, and by more drastic environment interventions (restructuring entire department floor). Trial Registration Nederlands Trial Register NTR2553 PMID:25542039

  7. Development and Pilot Evaluation of an Online Relapse-Prevention Program Based on Acceptance and Commitment Therapy for Chronic Pain Patients

    PubMed Central

    2015-01-01

    in each step. The program was evaluated positively by some participants. The evaluation showed that the online relapse-prevention program has the potential to support chronic pain patients in maintaining their changed behaviors and preventing relapses in avoidance and pain control behaviors. Trial Registration Nederlands Trial Register (NTR) Number: NTR4177; http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=4177 (Archived by WebCite at http://www.webcitation.org/6Ur6EFD1D). PMID:27025550

  8. Adherence to and effectiveness of an individually tailored home-based exercise program for frail older adults, driven by mobility monitoring: design of a prospective cohort study

    PubMed Central

    2014-01-01

    of innovative technology in home-based exercise programs. Trial registration Nederlands Trial Register (NTR); trial number 4265. The study was prospectively registered (registration date 14/11/2013). PMID:24908049

  9. An Economic Evaluation of a Video- and Text-Based Computer-Tailored Intervention for Smoking Cessation: A Cost-Effectiveness and Cost-Utility Analysis of a Randomized Controlled Trial

    PubMed Central

    Stanczyk, Nicola E.; Smit, Eline S.; Schulz, Daniela N.; de Vries, Hein; Bolman, Catherine; Muris, Jean W. M.; Evers, Silvia M. A. A.

    2014-01-01

    required to assess changes in quality of life. Future studies with longer follow-up periods are needed to investigate whether cost-utility results regarding quality of life may change in the long run. Trial Registration Nederlands Trial Register NTR3102 PMID:25310007

  10. Case Finding of Mild Cognitive Impairment and Dementia and Subsequent Care; Results of a Cluster RCT in Primary Care

    PubMed Central

    van den Dungen, Pim; Moll van Charante, Eric P.; van de Ven, Peter M.; van Marwijk, Harm W. J.; van der Horst, Henriëtte E.; van Hout, Hein P. J.

    2016-01-01

    diagnoses. As we cannot exclude a clinically relevant effect, a larger study is warranted to replicate ours. Trial Registration Nederlands Trial Register NTR3389 PMID:27310616

  11. EMSO: European Multidisciplinary Seafloor Observatory

    NASA Astrophysics Data System (ADS)

    Favali, P.; Partnership, Emso

    2009-04-01

    Tecnologia Marina - Consejo Superior de Investigaciones Cientificas (Spain, ref. Juan Jose Danobeitia); UGOT-Goteborgs Universitet (Sweden, ref. Per Hall); HCMR-Hellenic Centre for Marine Research (Greece, ref. Vasilios Likousis); NOCS-National Oceanography Centre Southampton (United Kingdom, ref. Henry A. Ruhl); UiT-University of Tromsø (Norway, ref. Jürgen Mienert); FCT-Fundação para a Ciência e a Tecnologia (Portugal, ref. Jorge Miguel Alberto de Miranda); ITU-Istanbul Teknik Universitesi (Turkey, ref. Namik Çagatay); NIOZ-Stichting Koninklijk Nederlands Instituut voor Zeeonderzoek (The Netherlands, ref. Tjeerd C.E. van Weering).

  12. An Internet-Based Physical Activity Intervention to Improve Quality of Life of Inactive Older Adults: A Randomized Controlled Trial

    PubMed Central

    Broekhuizen, Karen; de Gelder, Jelle; Wijsman, Carolien A; Wijsman, Liselotte W; Westendorp, Rudi GJ; Verhagen, Evert; Slagboom, Pieternella E; van Mechelen, Willem; van Heemst, Diana; van der Ouderaa, Frans

    2016-01-01

    -to-vigorous physical activity (MVPA) and increase in quality of life. Conclusions Our study shows that an Internet-based physical activity program was effective in improving quality of life in 60-70-year-olds after 3 months, particularly in participants that reached their individually targeted increase in daily physical activity. Trial Registration Nederlands Trial Register: NTR 3045; http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=3045 (Archived by WebCite at http://www.webcitation.org/6fobg2sjJ) PMID:27122359

  13. Three-component Laser Doppler Anemometer for Gas Flowrate Measurements up to 5 500 m3/h

    NASA Astrophysics Data System (ADS)

    Dopheide, D.; Strunck, V.; Krey, E.-A.

    1994-01-01

    In the Physikalisch-Technische Bundesanstalt (PTB) the primary standard for on-line flowrate measurements using the laser Doppler anemometer (LDA) technique has been extended to a three-component LDA to improve velocity profile measurements in the boundary layers of a nozzle flow. The LDA flowrate measuring facility now consists of a two-colour argon ion LDA and a wavelength-stabilized GaAlAs diode laser LDA. The gas flowrate is obtained by numerical integration of the measured velocity profiles across the exit plane of the nozzle. High local resolution of the velocity profile measurements is achieved by perpendicular orientation of the measurement volumes of the two-component gas laser LDA and the semiconductor diode laser LDA (LD-LDA). This allows the resolution in the boundary layer to be improved significantly to velocity gradients. The present work presents the LD-LDA system for precise velocity profile measurements at flow velocities of up to 120 m/s; selected profile measurements are described in detail to demonstrate the high resolution and the symmetry of the flow profile. For the first time a wavelength-stabilized miniaturized diode laser LDA has been successfully applied in precise velocity measurements, and comparisons with well-established gas laser LDAs have been made. The uncertainty of the flowrate measurement up to 5 500 m3/h is 0,1% for air at atmospheric pressure. A turbine gas meter, type Elster G2500, was calibrated with the LDA and used as a transfer standard for an intercomparison with the Nederlands Meetinstituut (NMI) in the flowrate range up to 5 500 m3/h with and without the installation of perforated plates to condition the flow in the inlet section of the gas meter. The results of the comparison experiment clearly show the reliability and accuracy of the online flowrate measurement of gases and underline the necessity for a detailed research programme to investigate the relationship between installation effects, upstream flow conditions

  14. Effects of nurse-led motivational interviewing of patients with chronic musculoskeletal pain in preparation of rehabilitation treatment (PREPARE) on societal participation, attendance level, and cost-effectiveness: study protocol for a randomized controlled trial

    PubMed Central

    2013-01-01

    of the pre-treatment intervention, productivity losses, and healthcare utilization. Potential moderators and active ingredients of MI are explored. For the process evaluation, parameters such as MI fidelity, feasibility, and experiences are explored. Discussion The results of this study will provide evidence on the effectiveness of this MI-based pre-treatment in pain rehabilitation. Furthermore, a cost-effectiveness analysis and exploration of moderating and working mechanisms of MI and an extensive process evaluation takes place. Trial registration Nederlands trial register NTR3065 PMID:23548195

  15. Interventions to improve executive functioning and working memory in school-aged children with AD(H)D: a randomised controlled trial and stepped-care approach

    PubMed Central

    2013-01-01

    generalization effects of these interventions in a classroom situation. This study will contribute to this lack of information, especially information related to real classroom and academic situations. By taking into account the costs of both interventions, level of impairment and individual characteristics of the child (stepped-care approach) we will be able to address treatment more adequately for each individual in the future. Trial registration: Nederlands Trial Register NTR3415. PMID:23311304

  16. EMSO: European Multidisciplinary Seafloor Observatory

    NASA Astrophysics Data System (ADS)

    Favali, Paolo

    2010-05-01

    Waldmann); IMI-Irish Marine Institute (Ireland, ref. Michael Gillooly); UTM-CSIC-Unidad de Tecnologia Marina - Consejo Superior de Investigaciones Cientificas (Spain, ref. Juan Jose Danobeitia); UGOT-Goteborgs Universitet (Sweden, ref. Per Hall); HCMR-Hellenic Centre for Marine Research (Greece, ref. Vasilios Likousis); NOCS-National Oceanography Centre Southampton (United Kingdom, ref. Henry A. Ruhl); UiT-University of Tromsø (Norway, ref. Jürgen Mienert); FCT-Fundação para a Ciência e a Tecnologia (Portugal, ref. Jorge Miguel Alberto de Miranda); ITU-Istanbul Teknik Universitesi (Turkey, ref. Namik Çagatay); NIOZ-Stichting Koninklijk Nederlands Instituut voor Onderzoek der Zee (The Netherlands, ref. Jens Greinert).

  17. Determining Subsidence Rates with a Combination of RTK GNSS Data and National Geodetic Survey Data Sheets: A Case Study from SE Texas

    NASA Astrophysics Data System (ADS)

    Kruger, J. M.

    2016-12-01

    This study determines the rates of subsidence or uplift in coastal areas of SE Texas by comparing recent GNSS measurements to the original orthometric heights of previously installed National Geodetic Survey (NGS) benchmarks. Understanding subsidence rates in coastal areas of SE Texas is critical when determining its vulnerability to local sea level rise and flooding, as well as for accurate survey control. The study area includes major metropolitan and industrial areas as well as more rural areas at risk for flooding and hurricane surge. The resurveying methods used in this RTK GNSS study allow a large area to be covered relatively quickly with enough detail to determine subsidence rates that are averaged over several decades, and identify at-risk regions that can be monitored more closely with permanent or campaign-style measurements. The most recent measurements were acquired using a Trimble R8 GNSS system on all NGS benchmarks found in the study area. Differential corrections were applied in real time using a VRS network of base stations. Nominal vertical accuracies were 1.5 to 3.0 cm for a 2 to 5 minute reading. Usually three readings were measured and averaged for the final result. A total of 340 benchmarks were used for vertical rate calculations. Original NGS elevations were subtracted from the new elevations and divided by the number of years between the two elevation measurements to determine the average subsidence or uplift rate of the benchmark. Besides inaccuracies in the NGS datasheet and re-measured elevations, another source of error includes uncertainties in the year the NGS datasheet elevations were measured. Overall, vertical rates of change vary from -6 to -15 mm/yr subsidence in Port Arthur, Nederland, and other areas of Jefferson County, as well as in areas northwest of Beaumont, Texas. Other areas with subsidence rates between -10 and -4 mm/yr include parts of the Bolivar Peninsula in Galveston County, northeastern Chambers County, and the

  18. Case Finding of Mild Cognitive Impairment and Dementia and Subsequent Care; Results of a Cluster RCT in Primary Care.

    PubMed

    van den Dungen, Pim; Moll van Charante, Eric P; van de Ven, Peter M; van Marwijk, Harm W J; van der Horst, Henriëtte E; van Hout, Hein P J

    2016-01-01

    clinically relevant effect, a larger study is warranted to replicate ours. Nederlands Trial Register NTR3389.

  19. Favourable effects of consuming a Palaeolithic-type diet on characteristics of the metabolic syndrome: a randomized controlled pilot-study.

    PubMed

    Boers, Inge; Muskiet, Frits Aj; Berkelaar, Evert; Schut, Erik; Penders, Ria; Hoenderdos, Karine; Wichers, Harry J; Jong, Miek C

    2014-10-11

    unintended weight loss. No changes were observed for intestinal permeability, inflammation and salivary cortisol. We conclude that consuming a Palaeolithic-type diet for two weeks improved several cardiovascular risk factors compared to a healthy reference diet in subjects with the metabolic syndrome. Nederlands Trial Register NTR3002.

  20. The effects of a psychological intervention directed at optimizing immune function: study protocol for a randomized controlled trial.

    PubMed

    Schakel, Lemmy; Veldhuijzen, Dieuwke S; van Middendorp, Henriët; Prins, Corine; Joosten, Simone A; Ottenhoff, Tom H M; Visser, Leo G; Evers, Andrea W M

    2017-05-26

    heart rate and skin conductance in response to the psychophysiological tasks after the BCG vaccination. The innovative design features of this study - e.g., combining guided e-health CBT with health-related serious gaming elements and incorporating immunological and psychophysiological challenges - will provide valuable information on the effects of a psychological intervention on both self-reported and physiological health outcomes. This study will offer further insights into the mechanisms underlying the link between psychological factors and health outcomes and is anticipated to contribute to the optimization of health care strategies. Nederlands Trial Register, NTR5610 . Registered on 4 January 2016.

  1. Process evaluation of a tailored mobile health intervention aiming to reduce fatigue in airline pilots.

    PubMed

    van Drongelen, Alwin; Boot, Cécile R L; Hlobil, Hynek; Smid, Tjabe; van der Beek, Allard J

    2016-08-26

    participants rated the intervention with a 6.4 (SD 1.6). Adherence was not associated with compliance, but was associated with satisfaction (p ≤ 0.001). Pilots of 35 to 45 year old were significantly more interested in advice regarding physical activity than their colleagues, and short-haul pilots were more interested in advice regarding nutrition compared to long-haul pilots. The MORE Energy intervention was well received, resulting in an adequate reach and a high dose delivered. The compliance and satisfaction scores indicate that engagement and functionality should be enhanced, and the content and applicability of the advices should be improved to appeal all subgroups of the target population. Nederlands Trial Register NTR2722 . Registered 27 January 2011.

  2. Combination of international scoring system 3, high lactate dehydrogenase, and t(4;14) and/or del(17p) identifies patients with multiple myeloma (MM) treated with front-line autologous stem-cell transplantation at high risk of early MM progression-related death.

    PubMed

    Moreau, Philippe; Cavo, Michele; Sonneveld, Pieter; Rosinol, Laura; Attal, Michel; Pezzi, Annalisa; Goldschmidt, Hartmut; Lahuerta, Juan Jose; Marit, Gerald; Palumbo, Antonio; van der Holt, Bronno; Bladé, Joan; Petrucci, Maria Teresa; Neben, Kai; san Miguel, Jesus; Patriarca, Francesca; Lokhorst, Henk; Zamagni, Elena; Hulin, Cyrille; Gutierrez, Norma; Facon, Thierry; Caillot, Denis; Benboubker, Lotfi; Harousseau, Jean-Luc; Leleu, Xavier; Avet-Loiseau, Hervé; Mary, Jean-Yves

    2014-07-10

    To construct and validate among patients with multiple myeloma (MM) who were treated with intensive therapy a prognostic index of early MM progression-related death. Patient-level data from the Intergroupe Francophone du Myélome (IFM) 2005-01 trial (N = 482) were used to construct the prognostic index. The event was MM progression-related death within 2 years from treatment initiation. The index was validated using data from three other trials: the Gruppo Italiano Malattie Ematologiche dell' Adulto (GIMEMA) 26866138-MMY-3006 trial (N = 480), the Programa para el Estudio de la Terapéutica en Hemopatía Maligna (PETHEMA)-GEMMENOS65 trial (N = 390), and the Hemato-Oncologie voor Volwassenen Nederland (HOVON) -65/German-Speaking Myeloma Multicenter Group (GMMG) -HD4 trial (N = 827). The risk of early MM progression-related death was related to three independent prognostic variables: lactate dehydrogenase (LDH) higher than than normal, International Staging System 3 (ISS3), and adverse cytogenetics [t(4;14) and/or del(17p)]. These three variables enabled the definition of an ordinal prognostic classification composed of four scores (0 to 3). Patients with a score of 3, defined by the presence of t(4;14) and/or del(17p) in addition to ISS3 and/or high LDH, comprised 5% (20 of 387 patients) to 8% (94 of 1,139 patients) of the patients in the learning and validation samples, respectively, and they had a very poor prognosis. When applied to the population of 855 patients who had received bortezomib-based induction therapy in the four trials, the prognostic classification was also able to segregate patients into four categories, with a very poor prognosis attributed to patients with a score of 3. Our model allows the simple definition of a subgroup of MM patients at high risk of early MM progression-related death despite the use of the most modern and effective strategies. © 2014 by American Society of Clinical Oncology.

  3. Small bites versus large bites for closure of abdominal midline incisions (STITCH): a double-blind, multicentre, randomised controlled trial.

    PubMed

    Deerenberg, Eva B; Harlaar, Joris J; Steyerberg, Ewout W; Lont, Harold E; van Doorn, Helena C; Heisterkamp, Joos; Wijnhoven, Bas P L; Schouten, Willem R; Cense, Huib A; Stockmann, Hein B A C; Berends, Frits J; Dijkhuizen, F Paul H L J; Dwarkasing, Roy S; Jairam, An P; van Ramshorst, Gabrielle H; Kleinrensink, Gert-Jan; Jeekel, Johannes; Lange, Johan F

    2015-09-26

    Incisional hernia is a frequent complication of midline laparotomy and is associated with high morbidity, decreased quality of life, and high costs. We aimed to compare the large bites suture technique with the small bites technique for fascial closure of midline laparotomy incisions. We did this prospective, multicentre, double-blind, randomised controlled trial at surgical and gynaecological departments in ten hospitals in the Netherlands. Patients aged 18 years or older who were scheduled to undergo elective abdominal surgery with midline laparotomy were randomly assigned (1:1), via a computer-generated randomisation sequence, to receive small tissue bites of 5 mm every 5 mm or large bites of 1 cm every 1 cm. Randomisation was stratified by centre and between surgeons and residents with a minimisation procedure to ensure balanced allocation. Patients and study investigators were masked to group allocation. The primary outcome was the occurrence of incisional hernia; we postulated a reduced incidence in the small bites group. We analysed patients by intention to treat. This trial is registered at Clinicaltrials.gov, number NCT01132209 and with the Nederlands Trial Register, number NTR2052. Between Oct 20, 2009, and March 12, 2012, we randomly assigned 560 patients to the large bites group (n=284) or the small bites group (n=276). Follow-up ended on Aug 30, 2013; 545 (97%) patients completed follow-up and were included in the primary outcome analysis. Patients in the small bites group had fascial closures sutured with more stitches than those in the large bites group (mean number of stitches 45 [SD 12] vs 25 [10]; p<0·0001), a higher ratio of suture length to wound length (5·0 [1·5] vs 4·3 [1·4]; p<0·0001) and a longer closure time (14 [6] vs 10 [4] min; p<0·0001). At 1 year follow-up, 57 (21%) of 277 patients in the large bites group and 35 (13%) of 268 patients in the small bites group had incisional hernia (p=0·0220, covariate adjusted odds ratio 0·52

  4. Changing Behavioral Lifestyle Risk Factors Related to Cognitive Decline in Later Life Using a Self-Motivated eHealth Intervention in Dutch Adults.

    PubMed

    Aalbers, Teun; Qin, Li; Baars, Maria Ae; de Lange, Annet; Kessels, Roy Pc; Olde Rikkert, Marcel Gm

    2016-06-17

    in lifestyle changes in behavioral risk factors associated with cognitive decline, and these improvements lasted over the period of 1 year. Given the general aging of our workforce, this eHealth intervention opens new avenues for the widespread use of cost-effective self-motivated prevention programs aimed at prevention of early-stage cognitive decline and more self-management of their risk factors. Nederlands Trial Register: NTR4144; http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=4144 (Archived by WebCite at http://www.webcitation.org/6cZzwZSg3).

  5. Intrathecal baclofen treatment in dystonic cerebral palsy: a randomized clinical trial: the IDYS trial

    PubMed Central

    2013-01-01

    influence outcome. Discussion The results of this study will provide data for evidence-based use of intrathecal baclofen in dystonic cerebral palsy. Trial registration Nederlands Trial Register, NTR3642 PMID:24165282

  6. Which Questionnaire Should Be Used to Measure Quality-of-Life Utilities in Patients with Acute Leukemia? An Evaluation of the Validity and Interpretability of the EQ-5D-5L and Preference-Based Questionnaires Derived from the EORTC QLQ-C30.

    PubMed

    van Dongen-Leunis, Annemieke; Redekop, W Ken; Uyl-de Groot, Carin A

    The aim of this study was to assess the validity and interpretability of different preference-based questionnaires (generic 5-level EuroQol five-dimensional questionnaire [EQ-5D-5L], cancer-specific Quality of Life Questionnaire Preference-Based Measure, and European Organization of Randomized Controlled Trials 8 Dimension [EORTC-8D]) in patients with acute leukemia. Patients who participated in Hemato-Oncologie voor Volwassenen Nederland (HOVON - the Haemato Oncology Foundation for Adults in the Netherlands) clinical trials between 1999 and 2011 at a single hospital were invited to complete the questionnaires. Interpretability was evaluated by the frequency of incomplete data and highest and lowest possible scores. Content validity was evaluated by exploring the health-related quality-of-life domains included in the questionnaires. Construct validity was assessed using correlations with other quality-of-life scales (EQ-visual analogue scale score and global quality-of-life scale of the EORTC Quality of Life Questionnaire) and ability to distinguish between patients with different health statuses. Questionnaires were returned by 89% (111 of 125) of the patients. Six to seven respondents did not return full questionnaires. Perfect health on the EQ-5D-5L was reported by 32 respondents and many of them (N = 17) did report health problems on other questionnaires. All questionnaires were strongly correlated (range 0.61-0.78) with other quality-of-life scales and yielded substantially different utility values for patients with different health statuses. Nevertheless, the disease-specific preference-based questionnaires showed greater discriminatory power. Although the Quality of Life Questionnaire Preference-Based Measure and the EORTC-8D appear to have better validity, this study does not provide any strong evidence against the use of the EQ-5D-5L for measuring quality-of-life utilities in acute leukemia. However, our findings need to be confirmed in larger longitudinal

  7. The Effectiveness of Lifestyle Triple P in the Netherlands: A Randomized Controlled Trial

    PubMed Central

    Gerards, Sanne M. P. L.; Dagnelie, Pieter C.; Gubbels, Jessica S.; van Buuren, Stef; Hamers, Femke J. M.; Jansen, Maria W. J.; van der Goot, Odilia H. M.; de Vries, Nanne K.; Sanders, Matthew R.; Kremers, Stef P. J.

    2015-01-01

    positive effects on some parent reported child behaviors and parenting measures, no effects were visible on children’s body composition or objectively measured physical activity. Several adjustments of the intervention content are recommended, for example including a booster session. Trial Registration Nederlands Trial Register NTR 2555 PMID:25849523

  8. The (cost) effectiveness of an online intervention for pregnant women with affective symptoms: protocol of a randomised controlled trial.

    PubMed

    Heller, Hanna M; van Straten, Annemieke; de Groot, Christianne J M; Honig, Adriaan

    2014-08-14

    , internet-based PST will offer new possibilities to treat pregnant women for affective symptoms, to improve their perinatal outcome and to prevent the development of postpartum depressive disorders. Nederlands Trial Register: NTR4321.

  9. Effectiveness of the home-based alcohol prevention program "In control: no alcohol!": study protocol of a randomized controlled trial.

    PubMed

    Mares, Suzanne H W; van der Vorst, Haske; Lichtwarck-Aschoff, Anna; Schulten, Ingrid; Verdurmen, Jacqueline E E; Otten, Roy; Engels, Rutger C M E

    2011-08-04

    quickly be implemented as a standard alcohol prevention program on a large scale. Nederlands Trial Register NTR2564.

  10. Study protocol subacromial impingement syndrome: the identification of pathophysiologic mechanisms (SISTIM)

    PubMed Central

    2011-01-01

    controlled acromiohumeral translation assessments); Clinical phenotyping (Constant Score, DASH, WORC, and SF-36 scores). Discussion By relating anatomic properties, kinematics and muscle dynamics to subacromial volume, we expect to identify one or more predominant pathophysiological mechanisms in every SIS patient. These differences in underlying mechanisms are a reflection of the variations in symptoms, clinical scores and outcomes reported in literature. More insight in these mechanisms is necessary in order to optimize future diagnostic and treatment strategies for patients with SIS symptoms. Trial registration Dutch Trial Registry (Nederlands Trial Register) NTR2283. PMID:22168667

  11. The effectiveness of VIPP-V parenting training for parents of young children with a visual or visual-and-intellectual disability: study protocol of a multicenter randomized controlled trial.

    PubMed

    Overbeek, Mathilde M; Sterkenburg, Paula S; Kef, Sabina; Schuengel, Carlo

    2015-09-09

    ) and three months (T3) after the intervention. Parent-child dyads in the care-as-usual-only condition will be assessed at the same time points. Both intention-to-treat and completer analyses will be performed. Descriptive findings in pilot cases suggest benefits from VIPP-V, and compatibility with existing services for parents of children with a visual or visual-and-intellectual disability. The current study will provide insight into the effectiveness of this intervention for parents of children with a visual or visual-and-intellectual disability, and, if the intervention is effective, prepare the field for broad-scale implementation. Nederlands Trial Register NTR4306 (registered 5 December 2013).

  12. Using an eHealth Intervention to Stimulate Health Behavior for the Prevention of Cognitive Decline in Dutch Adults: A Study Protocol for the Brain Aging Monitor.

    PubMed

    Aalbers, Teun; Baars, Maria Ae; Qin, Li; de Lange, Annet; Kessels, Roy Pc; Olde Rikkert, Marcel Gm

    2015-11-10

    where no professional back-end is available. Nederlands Trial Register: NTR4144; http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=4144 (Archived by WebCite at http://www.webcitation.org/6cZzwZSg3).

  13. Acute effects of capsaicin on energy expenditure and fat oxidation in negative energy balance.

    PubMed

    Janssens, Pilou L H R; Hursel, Rick; Martens, Eveline A P; Westerterp-Plantenga, Margriet S

    2013-01-01

    Addition of capsaicin (CAPS) to the diet has been shown to increase energy expenditure; therefore capsaicin is an interesting target for anti-obesity therapy. We investigated the 24 h effects of CAPS on energy expenditure, substrate oxidation and blood pressure during 25% negative energy balance. Subjects underwent four 36 h sessions in a respiration chamber for measurements of energy expenditure, substrate oxidation and blood pressure. They received 100% or 75% of their daily energy requirements in the conditions '100%CAPS', '100%Control', '75%CAPS' and '75%Control'. CAPS was given at a dose of 2.56 mg (1.03 g of red chili pepper, 39,050 Scoville heat units (SHU)) with every meal. An induced negative energy balance of 25% was effectively a 20.5% negative energy balance due to adapting mechanisms. Diet-induced thermogenesis (DIT) and resting energy expenditure (REE) at 75%CAPS did not differ from DIT and REE at 100%Control, while at 75%Control these tended to be or were lower than at 100%Control (p = 0.05 and p = 0.02 respectively). Sleeping metabolic rate (SMR) at 75%CAPS did not differ from SMR at 100%CAPS, while SMR at 75%Control was lower than at 100%CAPS (p = 0.04). Fat oxidation at 75%CAPS was higher than at 100%Control (p = 0.03), while with 75%Control it did not differ from 100%Control. Respiratory quotient (RQ) was more decreased at 75%CAPS (p = 0.04) than at 75%Control (p = 0.05) when compared with 100%Control. Blood pressure did not differ between the four conditions. In an effectively 20.5% negative energy balance, consumption of 2.56 mg capsaicin per meal supports negative energy balance by counteracting the unfavorable negative energy balance effect of decrease in components of energy expenditure. Moreover, consumption of 2.56 mg capsaicin per meal promotes fat oxidation in negative energy balance and does not increase blood pressure significantly. Nederlands Trial Register; registration number NTR2944.

  14. Design of the Lifestyle Interventions for severe mentally ill Outpatients in the Netherlands (LION) trial; a cluster randomised controlled study of a multidimensional web tool intervention to improve cardiometabolic health in patients with severe mental illness.

    PubMed

    Looijmans, Anne; Jörg, Frederike; Bruggeman, Richard; Schoevers, Robert; Corpeleijn, Eva

    2017-03-21

    monitoring using standard protocols. Secondary outcomes include depressive and negative symptoms, cost-effectiveness, and barriers and facilitators in intervention implementation. Adequate health care should target both mental health and lifestyle behaviours in SMI patients. This trial contributes by studying a 12-month multidimensional lifestyle intervention as a potential evidence based (nursing) tool for targeting multiple lifestyle behaviours in SMI patients. Nederlands Trialregister NTR3765 (trialregister.nl; registered 21 December 2012).

  15. Combination of International Scoring System 3, High Lactate Dehydrogenase, and t(4;14) and/or del(17p) Identifies Patients With Multiple Myeloma (MM) Treated With Front-Line Autologous Stem-Cell Transplantation at High Risk of Early MM Progression–Related Death

    PubMed Central

    Moreau, Philippe; Cavo, Michele; Sonneveld, Pieter; Rosinol, Laura; Attal, Michel; Pezzi, Annalisa; Goldschmidt, Hartmut; Lahuerta, Juan Jose; Marit, Gerald; Palumbo, Antonio; van der Holt, Bronno; Bladé, Joan; Petrucci, Maria Teresa; Neben, Kai; san Miguel, Jesus; Patriarca, Francesca; Lokhorst, Henk; Zamagni, Elena; Hulin, Cyrille; Gutierrez, Norma; Facon, Thierry; Caillot, Denis; Benboubker, Lotfi; Harousseau, Jean-Luc; Leleu, Xavier; Avet-Loiseau, Hervé; Mary, Jean-Yves

    2014-01-01

    Purpose To construct and validate among patients with multiple myeloma (MM) who were treated with intensive therapy a prognostic index of early MM progression–related death. Patients and Methods Patient-level data from the Intergroupe Francophone du Myélome (IFM) 2005-01 trial (N = 482) were used to construct the prognostic index. The event was MM progression–related death within 2 years from treatment initiation. The index was validated using data from three other trials: the Gruppo Italiano Malattie Ematologiche dell' Adulto (GIMEMA) 26866138-MMY-3006 trial (N = 480), the Programa para el Estudio de la Terapéutica en Hemopatía Maligna (PETHEMA)–GEMMENOS65 trial (N = 390), and the Hemato-Oncologie voor Volwassenen Nederland (HOVON) –65/German-Speaking Myeloma Multicenter Group (GMMG) –HD4 trial (N = 827). Results The risk of early MM progression–related death was related to three independent prognostic variables: lactate dehydrogenase (LDH) higher than than normal, International Staging System 3 (ISS3), and adverse cytogenetics [t(4;14) and/or del(17p)]. These three variables enabled the definition of an ordinal prognostic classification composed of four scores (0 to 3). Patients with a score of 3, defined by the presence of t(4;14) and/or del(17p) in addition to ISS3 and/or high LDH, comprised 5% (20 of 387 patients) to 8% (94 of 1,139 patients) of the patients in the learning and validation samples, respectively, and they had a very poor prognosis. When applied to the population of 855 patients who had received bortezomib-based induction therapy in the four trials, the prognostic classification was also able to segregate patients into four categories, with a very poor prognosis attributed to patients with a score of 3. Conclusion Our model allows the simple definition of a subgroup of MM patients at high risk of early MM progression–related death despite the use of the most modern and effective strategies. PMID:24888806

  16. Evaluation of the role of Care Sport Connectors in connecting primary care, sport, and physical activity, and residents' participation in the Netherlands: study protocol for a longitudinal multiple case study design.

    PubMed

    Smit, E; Leenaars, K E F; Wagemakers, M A E; Molleman, G R M; Koelen, M A; van der Velden, J

    2015-11-23

    also the circumstances under which this will happen. The assessment in combination with general lessons learned from the different case studies will make it possible to determine whether CSCs are able to fulfill the policy aspiration and whether it would be beneficial to extend this function. Nederlands Trialregister NTR4986 . Registered 14 December 2014.

  17. Web-Based Cognitive Behavioral Therapy for Female Patients With Eating Disorders: Randomized Controlled Trial.

    PubMed

    ter Huurne, Elke D; de Haan, Hein A; Postel, Marloes G; van der Palen, Job; VanDerNagel, Joanne E L; DeJong, Cornelis A J

    2015-06-18

    measures (effect sizes between d=.34 to d=.49), except for Body Mass Index. WL participants also improved on most outcomes; however, effects were smaller in this group with significant between-group effects for eating disorder psychopathology (F201=9.42, P=.002, d=.44), body dissatisfaction (F201=13.16, P<.001, d=.42), physical health (F200=12.55, P<.001, d=.28), mental health (F203=4.88, P=.028, d=.24), self-esteem (F202=5.06, P=.026, d=.20), and social functioning (F205=7.93, P=.005, d=.29). Analyses for the individual subgroups BN, BED, and EDNOS showed that eating disorder psychopathology improved significantly over time among Web-based CBT participants in all three subgroups; however, the between-group effect was significant only for participants with BED (F78=4.25, P=.043, d=.61). Web-based CBT proved to be effective in improving eating disorder psychopathology and related health among female patients with eating disorders. Nederlands Trial Register (NTR): NTR2415; http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=2415 (Archived by WebCite at http://www.webcitation.org/6T2io3DnJ).

  18. Effectiveness of Web-Based Tailored Advice on Parents’ Child Safety Behaviors: Randomized Controlled Trial

    PubMed Central

    2014-01-01

    staircase (63.53% vs 71.94%; OR 0.69, 95% CI 0.53-0.88); top and bottom of staircase (68.94% vs 78.28%; OR 0.62, 95% CI 0.48-0.81); storage of cleaning products (30.33% vs 39.91%; OR 0.67, 95% CI 0.53-0.85); bathing of the child (23.46% vs 32.25%; OR 0.65, 95% CI 0.51-0.84); drinking hot fluids (34.84% vs 41.73%; OR 0.76, 95% CI 0.61-0.96); using rear hotplates (79.34% vs 85.27%; OR 0.67, 95% CI 0.50-0.90); and the total risk score in which a higher score indicates more unsafe behavior (mean 13.63, SD 6.12 vs mean 15.34, SD 6.07; beta –1.59, 95% CI –2.26 to –0.93). There were no significant differences for other specific behaviors between the two study conditions. Conclusions Compared to generic written materials, the E-Health4Uth home safety intervention seems more effective in promoting parents’ safety behavior for safe staircases, storage of cleaning products, bathing, drinking hot fluids, and cooking. This study supports the application of Web-based, tailored, safety advice for the prevention of unintentional injuries in the youth health care setting. Trial Registration Nederlands Trial Register: NTR1836; http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=1836 (Archived by WebCite at http://www.webcitation.org/6MPIGQxpx). PMID:24463421

  19. Changing Behavioral Lifestyle Risk Factors Related to Cognitive Decline in Later Life Using a Self-Motivated eHealth Intervention in Dutch Adults

    PubMed Central

    Qin, Li; Baars, Maria AE; de Lange, Annet; Kessels, Roy PC; Olde Rikkert, Marcel GM

    2016-01-01

    Dutch population, this eHealth intervention resulted in lifestyle changes in behavioral risk factors associated with cognitive decline, and these improvements lasted over the period of 1 year. Given the general aging of our workforce, this eHealth intervention opens new avenues for the widespread use of cost-effective self-motivated prevention programs aimed at prevention of early-stage cognitive decline and more self-management of their risk factors. Trial Registration Nederlands Trial Register: NTR4144; http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=4144 (Archived by WebCite at http://www.webcitation.org/6cZzwZSg3). PMID:27317506

  20. A Web-Based Computer-Tailored Alcohol Prevention Program for Adolescents: Cost-Effectiveness and Intersectoral Costs and Benefits.

    PubMed

    Drost, Ruben M W A; Paulus, Aggie T G; Jander, Astrid F; Mercken, Liesbeth; de Vries, Hein; Ruwaard, Dirk; Evers, Silvia M A A

    2016-04-21

    effective in comparison with CAU. ICERs differed for both perspectives, namely €40 and €79 from the health care perspective to €62 and €144 for the societal perspective per incremental reduction of one glass of alcohol per week and one binge drinking occasion per 30 days, respectively. Subgroup analyses showed, from both perspectives and for both outcome measures, that the intervention was cost-effective for older adolescents (aged 17-19 years) and those at a lower educational level and, from a health care perspective, the male and nonreligious adolescent subgroups. Computer-tailored feedback could be a cost-effective way to target alcohol use and binge drinking among adolescents. Including ICBs in the economic evaluation had an impact on the cost-effectiveness results of the analysis. It could be worthwhile to aim the intervention specifically at specific subgroups. Nederlands Trial Register: NTR4048; http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=4048 (Archived by Webcite at http://www.webcitation.org/6c7omN8wG).

  1. Cooling of High-Power LED Lamp Using a Commercial Paraffin Wax

    NASA Astrophysics Data System (ADS)

    Zmywaczyk, J.; Zbińkowski, P.; Smogór, H.; Olejnik, A.; Koniorczyk, P.

    2017-03-01

    Commercial paraffin wax used by Bolsius Nederland B.V. for manufacturing various kinds of candles was applied as a phase-change material (PCM) for cooling a 28 W high-power light emitting diode (LED) panel during its operation. The main problem arising during operation of an LED is thermal management. According to the manufacturer's datasheet specifications (BioSolution Ltd. www.biosolution.pl, the operating temperature range for the LED street lamp UL28W is (-30 {°}C) to (+40 {°}C). The object of the present study was an LED panel containing 28 pieces of high-power 1W LEDs connected in series (4 LEDs in each of the 7 rows) mounted on an aluminum plate of dimensions 80 mm by 135 mm. The tested aluminum plate was placed in a block made of aluminum with a hollow compartment containing Bolsius paraffin wax of density 914 kg\\cdot m^{-3} at room temperature. Temperatures were recorded using K-type thermocouples at selected locations of the tested LED panel for several values of the power supplied to it, while utilizing PCM and without it. As the manufacturer of Bolsius wax candles does not provide any data on the thermal properties of the material used, it was necessary to carry out micro-calorimetric research. Thermophysical properties of the paraffin wax such as the apparent specific heat, enthalpy of phase transition and temperature of phase change transition during heating and cooling were determined using the Netzsch DSC 214 Polyma. The Netzsch TG 209F3 Tarsus was used for TG/DTG measurements. DSC investigations revealed the following thermal transitions taking place during the first heating: solid-solid transition (onset 30.4 {°}C, peak at 40.9 {°}C), solid-liquid transition (onset 47.7 {°}C, peak at 54.9 {°}C, end at 58.3 {°}C), latent heat of energy storage 201 J\\cdot g^{-1}, apparent specific heat corresponding to peak at 41.5 {°}C (5.498 J\\cdot g^{-1}\\cdot K^{-1}). DTG investigations revealed that the decomposition of paraffin wax is a two

  2. Effectiveness of a Web-Based Computer-Tailored Multiple-Lifestyle Intervention for People Interested in Reducing their Cardiovascular Risk: A Randomized Controlled Trial.

    PubMed

    Storm, Vera; Dörenkämper, Julia; Reinwand, Dominique Alexandra; Wienert, Julian; De Vries, Hein; Lippke, Sonia

    2016-04-11

    % CI 0.09-0.16, P<.001; physical activity: beta=0.04, 95% CI 0.02-0.06, P<.001). Our findings indicate the general effectiveness and practicality of Web-based computer-tailored interventions in terms of increasing self-reported habit strength for physical activity and fruit and vegetable consumption. Self-efficacy and planning may play major roles in the mechanisms that facilitate the habit strength of these behaviors; therefore, they should be actively promoted in Web-based interventions. Although the results need to take into account the high dropout rates and medium effect sizes, a large number of people were reached and changes in habit strength were achieved after 3 months. Clinicaltrials.gov NCT01909349; https://clinicaltrials.gov/ct2/show/NCT01909349 (Archived by WebCite at http://www.webcitation.org/6g5F0qoft) and Nederlands Trial Register NTR3706 http://www.trialregister.nl/ trialreg/admin/rctview.asp?TC=3706 (Archived by WebCite at http://www.webcitation.org/6g5F5HMLX).

  3. Effectiveness of web-based tailored advice on parents' child safety behaviors: randomized controlled trial.

    PubMed

    van Beelen, Mirjam Elisabeth Johanna; Beirens, Tinneke Monique Jozef; den Hertog, Paul; van Beeck, Eduard Ferdinand; Raat, Hein

    2014-01-24

    .69, 95% CI 0.53-0.88); top and bottom of staircase (68.94% vs. 78.28%; OR 0.62, 95% CI 0.48-0.81); storage of cleaning products (30.33% vs. 39.91%; OR 0.67, 95% CI 0.53-0.85); bathing of the child (23.46% vs. 32.25%; OR 0.65, 95% CI 0.51-0.84); drinking hot fluids (34.84% vs. 41.73%; OR 0.76, 95% CI 0.61-0.96); using rear hotplates (79.34% vs. 85.27%; OR 0.67, 95% CI 0.50-0.90); and the total risk score in which a higher score indicates more unsafe behavior (mean 13.63, SD 6.12 vs. mean 15.34, SD 6.07; beta -1.59, 95% CI -2.26 to -0.93). There were no significant differences for other specific behaviors between the two study conditions. Compared to generic written materials, the E-Health4Uth home safety intervention seems more effective in promoting parents' safety behavior for safe staircases, storage of cleaning products, bathing, drinking hot fluids, and cooking. This study supports the application of Web-based, tailored, safety advice for the prevention of unintentional injuries in the youth health care setting. Nederlands Trial Register: NTR1836; http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=1836 (Archived by WebCite at http://www.webcitation.org/6MPIGQxpx).

  4. A Web-Based Computer-Tailored Alcohol Prevention Program for Adolescents: Cost-Effectiveness and Intersectoral Costs and Benefits

    PubMed Central

    2016-01-01

    intervention was more costly and more effective in comparison with CAU. ICERs differed for both perspectives, namely €40 and €79 from the health care perspective to €62 and €144 for the societal perspective per incremental reduction of one glass of alcohol per week and one binge drinking occasion per 30 days, respectively. Subgroup analyses showed, from both perspectives and for both outcome measures, that the intervention was cost-effective for older adolescents (aged 17-19 years) and those at a lower educational level and, from a health care perspective, the male and nonreligious adolescent subgroups. Conclusions Computer-tailored feedback could be a cost-effective way to target alcohol use and binge drinking among adolescents. Including ICBs in the economic evaluation had an impact on the cost-effectiveness results of the analysis. It could be worthwhile to aim the intervention specifically at specific subgroups. Trial Registration Nederlands Trial Register: NTR4048; http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=4048 (Archived by Webcite at http://www.webcitation.org/6c7omN8wG) PMID:27103154

  5. Sugarsquare, a Web-Based Patient Portal for Parents of a Child With Type 1 Diabetes: Multicenter Randomized Controlled Feasibility Trial.

    PubMed

    Boogerd, Emiel; Maas-Van Schaaijk, Nienke M; Sas, Theo C; Clement-de Boers, Agnes; Smallenbroek, Mischa; Nuboer, Roos; Noordam, Cees; Verhaak, Chris M

    2017-08-22

    index scores were related to the parents' frequency of logging on (ρ=.282, P=.03) and page-views (ρ=.304, P=.01). No significant differences in change in parenting stress between experimental and control group were found (F3,101=.49, P=.49). The trial can be considered feasible, considering the average enrollment refusal rate, baseline attrition rate and postrandomization attrition rate, compared to other eHealth studies, although lower than hypothesized. Implementing Sugarsquare in clinical practice was partly feasible, given moderate demand and acceptability in parent users and lack of potential efficacy. Parents who reported higher levels of parenting stress used Sugarsquare more often than other parents, although Sugarsquare did not reduce parenting stress. These results indicate that Web-based interventions are a suitable way of providing parents of children with T1D with additional support. Future studies should determine how Sugarsquare could reduce parenting stress, for instance by adding targeted interventions. Factors potentially contributing to successful implementation are suggested. Nederlands Trial Register Number: NTR3643; http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=3643 (Archived by WebCite at http://www.webcitation.org/6qihOVCi6).

  6. Glatiramer acetate treatment persistence - but not adherence - in multiple sclerosis patients is predicted by health-related quality of life and self-efficacy: a prospective web-based patient-centred study (CAIR study).

    PubMed

    Jongen, Peter Joseph; Lemmens, Wim A; Hoogervorst, Erwin L; Donders, Rogier

    2017-03-14

    -persistence in the highest quartile was 23.4 vs. 53.2% in the lowest quartile. Risk differentiation with respect to adherence was not possible. Based on these findings we propose a practical work-up scheme to identify patients with a high risk of non-persistence and to identify persistence-related factors. Findings suggest that pre-treatment physical HRQoL and control self-efficacy may identify RRMS patients with a high risk of early discontinuation of injectable DMD treatment. Targeting of high-risk patients may enable the efficient use of persistence-promoting measures. Nederlands Trial Register code: NTR2432 .

  7. The UK Lung Cancer Screening Trial: a pilot randomised controlled trial of low-dose computed tomography screening for the early detection of lung cancer.

    PubMed

    Field, John K; Duffy, Stephen W; Baldwin, David R; Brain, Kate E; Devaraj, Anand; Eisen, Tim; Green, Beverley A; Holemans, John A; Kavanagh, Terry; Kerr, Keith M; Ledson, Martin; Lifford, Kate J; McRonald, Fiona E; Nair, Arjun; Page, Richard D; Parmar, Mahesh Kb; Rintoul, Robert C; Screaton, Nicholas; Wald, Nicholas J; Weller, David; Whynes, David K; Williamson, Paula R; Yadegarfar, Ghasem; Hansell, David M

    2016-05-01

    .1%) were diagnosed with lung cancer; 36 out of 42 (85.7%) of the screen-detected cancers were identified as stage 1 or 2, and 35 (83.3%) underwent surgical resection as their primary treatment. Lung cancer was more common in the lowest socioeconomic group. Short-term adverse psychosocial consequences were observed in participants who were randomised to the intervention arm and in those who had a major lung abnormality detected, but these differences were modest and temporary. Rollout of screening as a service or design of a full trial would need to address issues of outreach. The health-economic analysis suggests that the intervention could be cost-effective but this needs to be confirmed using data on actual lung cancer mortality. The UK Lung Cancer Screening (UKLS) pilot was successfully undertaken with 4055 randomised individuals. The data from the UKLS provide evidence that adds to existing data to suggest that lung cancer screening in the UK could potentially be implemented in the 60-75 years age group, selected via the Liverpool Lung Project risk model version 2 and using CT volumetry-based management protocols. The UKLS data will be pooled with the NELSON (Nederlands Leuvens Longkanker Screenings Onderzoek: Dutch-Belgian Randomised Lung Cancer Screening Trial) and other European Union trials in 2017 which will provide European mortality and cost-effectiveness data. For now, there is a clear need for mortality results from other trials and further research to identify optimal methods of implementation and delivery. Strategies for increasing uptake and providing support for underserved groups will be key to implementation. Current Controlled Trials ISRCTN78513845. This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme and will be published in full in Health Technology Assessment; Vol. 20, No. 40. See the NIHR Journals Library website for further project information.

  8. Web-Based Cognitive Behavioral Therapy for Female Patients With Eating Disorders: Randomized Controlled Trial

    PubMed Central

    de Haan, Hein A; Postel, Marloes G; van der Palen, Job; VanDerNagel, Joanne EL; DeJong, Cornelis AJ

    2015-01-01

    =63.07, P<.001, d=.82) and all secondary outcome measures (effect sizes between d=.34 to d=.49), except for Body Mass Index. WL participants also improved on most outcomes; however, effects were smaller in this group with significant between-group effects for eating disorder psychopathology (F 201=9.42, P=.002, d=.44), body dissatisfaction (F 201=13.16, P<.001, d=.42), physical health (F 200=12.55, P<.001, d=.28), mental health (F 203=4.88, P=.028, d=.24), self-esteem (F 202=5.06, P=.026, d=.20), and social functioning (F 205=7.93, P=.005, d=.29). Analyses for the individual subgroups BN, BED, and EDNOS showed that eating disorder psychopathology improved significantly over time among Web-based CBT participants in all three subgroups; however, the between-group effect was significant only for participants with BED (F 78=4.25, P=.043, d=.61). Conclusions Web-based CBT proved to be effective in improving eating disorder psychopathology and related health among female patients with eating disorders. Trial Registration Nederlands Trial Register (NTR): NTR2415; http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=2415 (Archived by WebCite at http://www.webcitation.org/6T2io3DnJ). PMID:26088580

  9. The Influence of User Characteristics and a Periodic Email Prompt on Exposure to an Internet-Delivered Computer-Tailored Lifestyle Program

    PubMed Central

    van Osch, Liesbeth; Schulz, Daniela N; Kremers, Stef PJ; de Vries, Hein

    2012-01-01

    interval 10.65–78.52; P < .001). Conclusions Older, male, and employed participants, and those with a lower income, higher body mass index, and a relatively unhealthy lifestyle were more likely to initiate a CT module. Module completers predominantly had a higher income and age. The current program therefore succeeded in reaching those people who benefit most from online lifestyle interventions. However, these people tended to disengage from the program. This underlines the importance of additional research into program adjustments and strategies that can be used to stimulate prolonged program use. Furthermore, sending periodic email prompts significantly increased revisits to the program. Though promising, this effect was modest and needs to be further examined, in order to maximize the potential of periodic email prompting. Trial Registration Nederlands Trial Register (NTR: 1786) and Medical Ethics Committee of Maastricht University and the University Hospital Maastricht (NL2723506809/MEC0903016); http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=1786 (Archived by WebCite at http://www.webcitation.org/65hBXA6V7) PMID:22382037

  10. The UK Lung Cancer Screening Trial: a pilot randomised controlled trial of low-dose computed tomography screening for the early detection of lung cancer.

    PubMed Central

    Field, John K; Duffy, Stephen W; Baldwin, David R; Brain, Kate E; Devaraj, Anand; Eisen, Tim; Green, Beverley A; Holemans, John A; Kavanagh, Terry; Kerr, Keith M; Ledson, Martin; Lifford, Kate J; McRonald, Fiona E; Nair, Arjun; Page, Richard D; Parmar, Mahesh Kb; Rintoul, Robert C; Screaton, Nicholas; Wald, Nicholas J; Weller, David; Whynes, David K; Williamson, Paula R; Yadegarfar, Ghasem; Hansell, David M

    2016-01-01

    the control arm. A total of 1994 participants underwent CT scanning: 42 participants (2.1%) were diagnosed with lung cancer; 36 out of 42 (85.7%) of the screen-detected cancers were identified as stage 1 or 2, and 35 (83.3%) underwent surgical resection as their primary treatment. Lung cancer was more common in the lowest socioeconomic group. Short-term adverse psychosocial consequences were observed in participants who were randomised to the intervention arm and in those who had a major lung abnormality detected, but these differences were modest and temporary. Rollout of screening as a service or design of a full trial would need to address issues of outreach. The health-economic analysis suggests that the intervention could be cost-effective but this needs to be confirmed using data on actual lung cancer mortality. CONCLUSIONS The UK Lung Cancer Screening (UKLS) pilot was successfully undertaken with 4055 randomised individuals. The data from the UKLS provide evidence that adds to existing data to suggest that lung cancer screening in the UK could potentially be implemented in the 60-75 years age group, selected via the Liverpool Lung Project risk model version 2 and using CT volumetry-based management protocols. FUTURE WORK The UKLS data will be pooled with the NELSON (Nederlands Leuvens Longkanker Screenings Onderzoek: Dutch-Belgian Randomised Lung Cancer Screening Trial) and other European Union trials in 2017 which will provide European mortality and cost-effectiveness data. For now, there is a clear need for mortality results from other trials and further research to identify optimal methods of implementation and delivery. Strategies for increasing uptake and providing support for underserved groups will be key to implementation. TRIAL REGISTRATION Current Controlled Trials ISRCTN78513845. FUNDING This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme and will be published in full in Health

  11. Effectiveness of a Web-Based Computer-Tailored Multiple-Lifestyle Intervention for People Interested in Reducing their Cardiovascular Risk: A Randomized Controlled Trial

    PubMed Central

    Dörenkämper, Julia; Reinwand, Dominique Alexandra; Wienert, Julian; De Vries, Hein; Lippke, Sonia

    2016-01-01

    and vegetable consumption: beta=0.12, 95% CI 0.09-0.16, P<.001; physical activity: beta=0.04, 95% CI 0.02-0.06, P<.001). Conclusions Our findings indicate the general effectiveness and practicality of Web-based computer-tailored interventions in terms of increasing self-reported habit strength for physical activity and fruit and vegetable consumption. Self-efficacy and planning may play major roles in the mechanisms that facilitate the habit strength of these behaviors; therefore, they should be actively promoted in Web-based interventions. Although the results need to take into account the high dropout rates and medium effect sizes, a large number of people were reached and changes in habit strength were achieved after 3 months. Trial Registration Clinicaltrials.gov NCT01909349; https://clinicaltrials.gov/ct2/show/NCT01909349 (Archived by WebCite at http://www.webcitation.org/6g5F0qoft) and Nederlands Trial Register NTR3706 http://www.trialregister.nl/ trialreg/admin/rctview.asp?TC=3706 (Archived by WebCite at http://www.webcitation.org/6g5F5HMLX) PMID:27068880

  12. Use and Appreciation of a Tailored Self-Management eHealth Intervention for Early Cancer Survivors: Process Evaluation of a Randomized Controlled Trial

    PubMed Central

    Willems, Roy A; Bolman, Catherine A W; Mesters, Ilse; Zambon, Victor; Gijsen, Brigitte CM; Lechner, Lilian

    2016-01-01

    early cancer survivors. Results indicated that the module referral advice might be a meaningful intervention component to guide the users in following a preferred selection of modules. These results indicate that the fully automated Web-based KNW provides personal relevant and valuable information and support for early cancer survivors. Therefore, this intervention can complement usual cancer aftercare and may serve as a first step in a stepped-care approach. Conclusions The KNW in general and more specifically the KNW modules were well used and highly appreciated by early cancer survivors. Indications were found that the module referral advice might be a meaningful intervention component to guide the users in following a preferred selection of modules. These results indicate that the fully automated Web-based KNW provides personal relevant and valuable information and support for early cancer survivors. Therefore, this intervention can complement usual cancer aftercare and may serve as a first step in a stepped-care approach. Trial Registration Nederlands Trial Register: NTR3375; http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=3375 (Archived by WebCite at http://www.webcitation.org/6jo4jO7kb) PMID:27554525

  13. Interpretation of heavy rainfall spatial distribution in mountain watersheds by copula functions

    NASA Astrophysics Data System (ADS)

    Grossi, Giovanna; Balistrocchi, Matteo

    2016-04-01

    hydro-meteorological network, consisting of about 30 rain gauges and 10 hydrometers, monitors this medium-size watershed. A decade of rainfall-runoff event observations are available. Severe rainfall events were identified with reference to a main raingauge station, by using an interevent time definition and a depth threshold. Rainfall depths were thus derived and the spatial variability of their association degree was represented by using the Kendall coefficient. A unique copula model based on Gumbel copula function was finally found to be suitable to represent the dependence structure relating to rainfall depths observed in distinct raingauges. Bardossy A., Pegram G. (2009), Copula based multisite model for daily precipitation simulation, Hydrol. Earth Syst. Sci., 13, 2299-2314. Genest C., Rémilland B., Beaudoin D. (2009), Goodness-of-fit tests for copulas: a review and a power study, Insur. Math. Econ., 44(2), 199-213. Joe H. (1997), Multivariate models and dependence concepts, Chapman and Hall, London. Nelsen R. B. (2006), An introduction to copulas, second ed., Springer, New York. Salvadori G., De Michele C., Kottegoda N. T., Rosso R. (2007), Extremes in nature: an approach using copulas, Springer, Dordrecht, The Nederlands.

  14. Self-Management Support Program for Patients With Cardiovascular Diseases: User-Centered Development of the Tailored, Web-Based Program Vascular View

    PubMed Central

    van Gaal, Betsie GI; Bredie, Sebastian JH; Nijhuis-van der Sanden, Maria WG; van Dulmen, Sandra

    2017-01-01

    with CVD as role models and personalized feedback, diaries, and exercises. The adoption and implementation plan (Step 5) was set up in collaboration with the members of the two expert groups and consisted of a written and digital instruction manual, a flyer, bimonthly newsletters, and reminders by email and telephone to (re-)visit the program. The potential effectiveness of Vascular View will be evaluated (Step 6) in an early RCT to gain insight into relevant outcome variables and related effect sizes, and a process evaluation to identify intervention fidelity, potential working mechanisms, user statistics, and/or satisfaction. Conclusion A comprehensive, multi-component, tailored, Web-based, self-management support program and an early RCT were developed in order to empower patients to self-manage their CVD. Trial Registration Nederlands Trial Register NTR5412; http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=5412 (Archived by WebCite at http://www.webcitation.org/6jeUFVj40) PMID:28179214

  15. Prevention of multiple pregnancies in couples with unexplained or mild male subfertility: randomised controlled trial of in vitro fertilisation with single embryo transfer or in vitro fertilisation in modified natural cycle compared with intrauterine insemination with controlled ovarian hyperstimulation

    PubMed Central

    Bensdorp, A J; Tjon-Kon-Fat, R I; Bossuyt, P M M; Koks, C A M; Oosterhuis, G J E; Hoek, A; Hompes, P G A; Broekmans, F J M; Verhoeve, H R; de Bruin, J P; van Golde, R; Repping, S; Cohlen, B J; Lambers, M D A; van Bommel, P F; Slappendel, E; Perquin, D; Smeenk, J M; Pelinck, M J; Gianotten, J; Hoozemans, D A; Maas, J W M; Eijkemans, M J C; van der Veen, F; Mol, B W J

    2015-01-01

    0.91 to 1.34) for in vitro fertilisation with single embryo transfer and 0.91 (0.73 to 1.14) for in vitro fertilisation in a modified natural cycle. These 95% confidence intervals do not extend below the predefined threshold of 0.69 for inferiority. Multiple pregnancy rates per ongoing pregnancy were 6% (7/121) after in vitro fertilisation with single embryo transfer, 5% (5/102) after in vitro fertilisation in a modified natural cycle, and 7% (8/119) after intrauterine insemination with ovarian hyperstimulation (one sided P=0.52 for in vitro fertilisation with single embryo transfer compared with intrauterine insemination with ovarian hyperstimulation; one sided P=0.33 for in vitro fertilisation in a modified natural cycle compared with intrauterine insemination with controlled ovarian hyperstimulation). Conclusions In vitro fertilisation with single embryo transfer and in vitro fertilisation in a modified natural cycle were non-inferior to intrauterine insemination with controlled ovarian hyperstimulation in terms of the birth of a healthy child and showed comparable, low multiple pregnancy rates. Trial registration Current Controlled Trials ISRCTN52843371; Nederlands Trial Register NTR939. PMID:25576320

  16. Prevention of multiple pregnancies in couples with unexplained or mild male subfertility: randomised controlled trial of in vitro fertilisation with single embryo transfer or in vitro fertilisation in modified natural cycle compared with intrauterine insemination with controlled ovarian hyperstimulation.

    PubMed

    Bensdorp, A J; Tjon-Kon-Fat, R I; Bossuyt, P M M; Koks, C A M; Oosterhuis, G J E; Hoek, A; Hompes, P G A; Broekmans, F J M; Verhoeve, H R; de Bruin, J P; van Golde, R; Repping, S; Cohlen, B J; Lambers, M D A; van Bommel, P F; Slappendel, E; Perquin, D; Smeenk, J M; Pelinck, M J; Gianotten, J; Hoozemans, D A; Maas, J W M; Eijkemans, M J C; van der Veen, F; Mol, B W J; van Wely, M

    2015-01-09

    .73 to 1.14) for in vitro fertilisation in a modified natural cycle. These 95% confidence intervals do not extend below the predefined threshold of 0.69 for inferiority. Multiple pregnancy rates per ongoing pregnancy were 6% (7/121) after in vitro fertilisation with single embryo transfer, 5% (5/102) after in vitro fertilisation in a modified natural cycle, and 7% (8/119) after intrauterine insemination with ovarian hyperstimulation (one sided P=0.52 for in vitro fertilisation with single embryo transfer compared with intrauterine insemination with ovarian hyperstimulation; one sided P=0.33 for in vitro fertilisation in a modified natural cycle compared with intrauterine insemination with controlled ovarian hyperstimulation). In vitro fertilisation with single embryo transfer and in vitro fertilisation in a modified natural cycle were non-inferior to intrauterine insemination with controlled ovarian hyperstimulation in terms of the birth of a healthy child and showed comparable, low multiple pregnancy rates.Trial registration Current Controlled Trials ISRCTN52843371; Nederlands Trial Register NTR939. © Bensdorp et al 2015.

  17. Occurrence and lung cancer probability of new solid nodules at incidence screening with low-dose CT: analysis of data from the randomised, controlled NELSON trial.

    PubMed

    Walter, Joan E; Heuvelmans, Marjolein A; de Jong, Pim A; Vliegenthart, Rozemarijn; van Ooijen, Peter M A; Peters, Robin B; Ten Haaf, Kevin; Yousaf-Khan, Uraujh; van der Aalst, Carlijn M; de Bock, Geertruida H; Mali, Willem; Groen, Harry J M; de Koning, Harry J; Oudkerk, Matthijs

    2016-07-01

    found, representing 4% of all new solid nodules. 34 (68%) lung cancers were diagnosed at stage I. Nodule volume had a high discriminatory power (area under the receiver operating curve 0·795 [95% CI 0·728-0·862]; p<0·0001). Nodules smaller than 27 mm(3) had a low probability of lung cancer (two [0·5%] of 417 nodules; lung cancer probability 0·5% [95% CI 0·0-1·9]), nodules with a volume of 27 mm(3) up to 206 mm(3) had an intermediate probability (17 [3·1%] of 542 nodules; lung cancer probability 3·1% [1·9-5·0]), and nodules of 206 mm(3) or greater had a high probability (29 [16·9%] of 172 nodules; lung cancer probability 16·9% [12·0-23·2]). A volume cutoff value of 27 mm(3) or greater had more than 95% sensitivity for lung cancer. Our study shows that new solid nodules are detected at each screening round in 5-7% of individuals who undergo screening for lung cancer with low-dose CT. These new nodules have a high probability of malignancy even at a small size. These findings should be considered in future screening guidelines, and new solid nodules should be followed up more aggressively than nodules detected at baseline screening. Zorgonderzoek Nederland Medische Wetenschappen and Koningin Wilhelmina Fonds Kankerbestrijding. Copyright © 2016 Elsevier Ltd. All rights reserved.

  18. Effectiveness of a Web-Based Tailored Intervention (E-health4Uth) and Consultation to Promote Adolescents’ Health: Randomized Controlled Trial

    PubMed Central

    Bannink, Rienke; Broeren, Suzanne; Joosten-van Zwanenburg, Evelien; van As, Els; van de Looij-Jansen, Petra

    2014-01-01

    consultation intervention showed minor positive results in the mental health status of adolescents (SDQ: B=−0.60, 95% CI −1.17 to −0.04), but a negative effect on drug use among boys (OR 0.36, 95% CI 0.13-0.96). In the subgroup of adolescents who were at risk of mental health problems at baseline (and referred for a consultation with the nurse), the E-health4Uth and consultation group showed minor to moderate positive results in mental health status (SDQ: B=−1.79, 95% CI −3.35 to −0.22; YSR: B=−9.11, 95% CI −17.52 to −0.71) and health-related quality of life (B=7.81, 95% CI 2.41-13.21) at follow-up compared to adolescents in the control group who were at risk of mental health problems at baseline. Conclusions Findings from this study support the use of the E-health4Uth and consultation intervention in promoting the well-being of adolescents at risk of mental health problems. Future research is needed to further evaluate the effects of the consultation as a standalone intervention, and the dual approach of further tailored eHealth messages and a consultation. Trial Registration Nederlands Trial Register: NTR 3596; http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=3596 (Archived by WebCite at http://www.webcitation.org/6PmgrPOuv). PMID:24878521

  19. [Veterinarians:'Watch your affairs!'].

    PubMed

    Vos, J H; Deleu, S A; Heling, W; de Vries, A R; Zeeuwen, A A

    2000-09-15

    The most relevant results of a written questionnaire among veterinarians in the Netherlands are presented and discussed. The inquiry was performed by MarketResponse Nederland BV. The objective was to get an overview of the current perception and the future view of the profession. The response was 37%. Most respondents (66%) were practitioners, 7% were active in research or teaching institutions, 5% were governmental employees, 5% were employed in industry, and 17% did not belong to any of these categories (retired, unemployed etc.). Forty-seven per cent of the veterinarians practised mainly small animal medicine, 24% large animal medicine (cattle 15%, swine 8%, and poultry 1%), and 4% equine medicine; 24% worked in mixed practices. This division reflects the real-life situation. The percentage of female respondents was considerably higher in the group of recent graduates than in the other groups of graduates (increasing from 27% in the graduation period 1980-1989 to 56% in the period 1990-1999). Sixty per cent of the veterinarians worked more than 40 hours a week. Veterinarians considered themselves reliable, honest, professional, client-minded, and animal-friendly. According to them, the public perceived veterinarians as being animal-friendly, professional, and reliable. Veterinarians were less satisfied in their current position than other professional groups, particularly with regard to their income. Their current market position was considered indifferent or good. This position was influenced negatively by the decrease in the number of animals and competition from non-veterinarians and others. The situation could be improved by collaboration and practice fusions, specialization, and differentiation. More demanding and price-conscious clients and governmental regulations were considered important trends. Social, management, and marketing skills, increased knowledge and cooperation, and a vision of future developments were considered essential in order to be able

  20. Use and Effectiveness of a Video- and Text-Driven Web-Based Computer-Tailored Intervention: Randomized Controlled Trial.

    PubMed

    Walthouwer, Michel Jean Louis; Oenema, Anke; Lechner, Lilian; de Vries, Hein

    2015-09-25

    intervention condition that matched their preferred intervention delivery format. There were no significant interaction terms for any of the outcome variables; a match and more intervention use did not result in better intervention effects. Participants with a high BMI and participants who felt involved and supported by the intervention were more likely to use the intervention more often. Video delivery of tailored feedback does not increase the use of Web-based computer-tailored interventions. However, intervention use can potentially be increased by delivering intervention content via participants' preferred intervention delivery format and creating feelings of relatedness. Because more intervention use was not associated with better intervention outcomes, more research is needed to examine the optimum number of intervention sessions in terms of maximizing use and effects. Nederlands Trial Register: NTR3501; http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=3501 (Archived by WebCite at http://www.webcitation.org/6b2tsH8Pk).

  1. The Glanerbrug Breccia: Evidence for a Separate L/LL-Chondritic Parent Body?

    NASA Astrophysics Data System (ADS)

    Welten, K. C.; Lindner, L.; Poorter, R. P. E.; Kallemeyn, G. W.; Rubin, A. E.; Wasson, J. T.

    1992-07-01

    . Wasson and coworkers for their hospitality at UCLA. This work was financially supported by the "Nederlands Organisatie voor Wetenschappelijk Onderzoek" (NWO). References. 1. Lindner L. et al. (1990) Meteoritics 25, 379 (abs.); 2. Bunch T.E. and Rajan R.S. (1988) in Meteorites and the Early Solar System (eds. J.F. Kerridge and M.S. Matthews), pp. 144-164, Univ. Arizona Press, Tucson, Arizona; 3. Kallemeyn, G.W. et al. (1989) GCA 53, 2747-2767; 4. Rubin A.E. (1990) GCA 54, 1217-1232; 5. Schultz L. (pers. comm.); 6. Wasson J.T. and Wang S. (1991), Meteoritics 26, 161-167.

  2. A Vertical Differential Configuration in GPR prospecting

    NASA Astrophysics Data System (ADS)

    Persico, Raffaele; Pochanin, Gennadiy; Varianytsia-Roshchupkina, Liudmyla; Catapano, Ilaria; Gennarelli, Gianluca; Soldovieri, Francesco

    2015-04-01

    and receiving modules of antenna", Patent 81652 Ukraine: IPC (2006) H01Q 9/00 H01Q 19/10 / publ. 25.01.08, Bull. N. 2 [6] G.P. Pochanin, "Some Advances in UWB GPR," in "Unexploded Ordnance Detection and Mitigation, - NATO Science for Peace and Security Series -B: Physics and Biophysics - Ed. by Jim Byrnes, Springer: Dordrecht, (The Nederland), 2009. pp.223-233. [7] R. Persico, F. Soldovieri, R. Pierri, "Convergence Properties of a Quadratic Approach to the Inverse Scattering Problem", Journal of Optical Society of America Part A, vol. 19, n. 12, pp. 2424-2428, December 2002. [8] R. Pierri, G. Leone, F. Soldovieri, R. Persico, "Electromagnetic inversion for subsurface applications under the distorted Born approximation" Nuovo Cimento, vol. 24C, N. 2, pp 245-261, March-April 2001. [9] R. Persico, Introduction to ground penetrating Radar: Inverse Scattering and data Processing, in print on Wiley and Sons, 2014, ISBN 9781118305003.

  3. Hydrogeological properties of bank storage area in Changwon city, Korea

    NASA Astrophysics Data System (ADS)

    Hamm, S.-Y.; Kim, H.-S.; Cheong, J.-Y.; Ryu, S. M.; Kim, M. J.

    2003-04-01

    Bank filtrated water has been used in developed countries such as United States, France, Germany, Austria, Nederland and so on. In Korea, most of the drinking water is provided from the surface water. However, drinking water acquisition is becoming difficult due to the degradation of surface water quality. In special, the quality of drinking water source is much lower in downstream area than in upstream area. Thus, the use of bank filtrated water is getting attracted by central and local governments in Korea. The bank filtrated water was surveyed in the areas of Yeongsan river, Nakdong river, Geum river and Han river. Up to present, however, the downstream areas of Nakdong river are most suitable places to apply the bank filtration system. This study investigates hydrogeological characteristics of bank-storage area located in Daesan- Myeon, Changwon city, adjacent the downstream of Nakdong river. Changwon city is the capital city of Gyeongsangnam-Do province. Changwon city uses water derived from Nakdong river as municipal water. However, the quantity and quality of the river water are gradually decreased. Thus, Changwon city developed two sites of bank filtration system in Daesan-myeon and Buk-myeon. Pumping rate is 2,000m3/day at present and will be increased to 60,000m3/day in Daesan-myeon site at the end of the first stage of the project. For the study, we conducted pumping tests four times on seven pumping wells (PW1, PW2, PW3, PW4, PW5, PW6, and PW7) and twelve drill holes (BH-2, OW2-OW12) in the area of 370 m x 100 m. Pumping wells PW1 and PW2 were drilled in 1999 by Samjung Engineering Co. and pumping wells PW3, PW4, PW5, PW6 and PW7 were drilled in 2000 by Donga Construction Co. and Daeduk Gongyeong Co. The pumping wells are located at 45-110 meters from Nakdong riverside. The geology of the study area is composed of volcanic rocks (Palryeongsan tuff and Jusasan andesitic rock) and alluvium. Palryeongsan tuff consists of mostly green tuff with partly

  4. High Level of Integration in Integrated Disease Management Leads to Higher Usage in the e-Vita Study: Self-Management of Chronic Obstructive Pulmonary Disease With Web-Based Platforms in a Parallel Cohort Design.

    PubMed

    Talboom-Kamp, Esther Pwa; Verdijk, Noortje A; Kasteleyn, Marise J; Harmans, Lara M; Talboom, Irvin Jsh; Numans, Mattijs E; Chavannes, Niels H

    2017-05-31

    -Efficacy Scale [GSES]). All analyses were adjusted for age and gender. Of the 702 invited COPD patients, 215 (30.6%) registered to a platform. Of the 82 patients in group 1 (high integration IDM), 36 were in group 1A (personal assistance) and 46 in group 1B (low assistance). Of the 96 patients in group 2 (medium integration IDM), 44 were in group 2A (telephone assistance) and 52 in group 2B (low assistance). A total of 37 patients participated in group 3 (no integration IDM). In all, 107 users (49.8%) visited the platform at least once in the 15-month period. The mean number of sessions differed between the three groups (group 1: mean 10.5, SD 1.3; group 2: mean 8.8, SD 1.4; group 3: mean 3.7, SD 1.8; P=.01). The mean number of sessions differed between the high-assistance and low-assistance groups in groups 1 and 2 (high: mean 11.8, SD 1.3; low: mean 6.7, SD 1.4; F1,80=6.55, P=.01). High-assistance participants used more services (mean 45.4, SD 6.2) than low-assistance participants (mean 21.2, SD 6.8; F1,80=6.82, P=.01). No association was found between educational level and usage and between GSES and usage. Use of a self-management platform is higher when participants receive adequate personal assistance about how to use the platform. Blended care, where digital health and usual care are integrated, will likely lead to increased use of the online program. Future research should provide additional insights into the preferences of different patient groups. Nederlands Trial Register NTR4098; http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=4098 (Archived by WebCite at http://www.webcitation.org/6qO1hqiJ1).

  5. High Level of Integration in Integrated Disease Management Leads to Higher Usage in the e-Vita Study: Self-Management of Chronic Obstructive Pulmonary Disease With Web-Based Platforms in a Parallel Cohort Design

    PubMed Central

    Verdijk, Noortje A; Kasteleyn, Marise J; Harmans, Lara M; Talboom, Irvin JSH; Numans, Mattijs E; Chavannes, Niels H

    2017-01-01

    -efficacy level (General Self-Efficacy Scale [GSES]). All analyses were adjusted for age and gender. Results Of the 702 invited COPD patients, 215 (30.6%) registered to a platform. Of the 82 patients in group 1 (high integration IDM), 36 were in group 1A (personal assistance) and 46 in group 1B (low assistance). Of the 96 patients in group 2 (medium integration IDM), 44 were in group 2A (telephone assistance) and 52 in group 2B (low assistance). A total of 37 patients participated in group 3 (no integration IDM). In all, 107 users (49.8%) visited the platform at least once in the 15-month period. The mean number of sessions differed between the three groups (group 1: mean 10.5, SD 1.3; group 2: mean 8.8, SD 1.4; group 3: mean 3.7, SD 1.8; P=.01). The mean number of sessions differed between the high-assistance and low-assistance groups in groups 1 and 2 (high: mean 11.8, SD 1.3; low: mean 6.7, SD 1.4; F1,80=6.55, P=.01). High-assistance participants used more services (mean 45.4, SD 6.2) than low-assistance participants (mean 21.2, SD 6.8; F1,80=6.82, P=.01). No association was found between educational level and usage and between GSES and usage. Conclusions Use of a self-management platform is higher when participants receive adequate personal assistance about how to use the platform. Blended care, where digital health and usual care are integrated, will likely lead to increased use of the online program. Future research should provide additional insights into the preferences of different patient groups. Trial Registration Nederlands Trial Register NTR4098; http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=4098 (Archived by WebCite at http://www.webcitation.org/6qO1hqiJ1) PMID:28566268

  6. Lung cancer probability in patients with CT-detected pulmonary nodules: a prespecified analysis of data from the NELSON trial of low-dose CT screening.

    PubMed

    Horeweg, Nanda; van Rosmalen, Joost; Heuvelmans, Marjolein A; van der Aalst, Carlijn M; Vliegenthart, Rozemarijn; Scholten, Ernst Th; ten Haaf, Kevin; Nackaerts, Kristiaan; Lammers, Jan-Willem J; Weenink, Carla; Groen, Harry J; van Ooijen, Peter; de Jong, Pim A; de Bock, Geertruida H; Mali, Willem; de Koning, Harry J; Oudkerk, Matthijs

    2014-11-01

    volume of 100 mm(3) or smaller (0·6% [95% CI 0·4-0·8]) or maximum transverse diameter smaller than 5 mm (0·4% [0·2-0·7]), and not significantly different from participants without nodules (0·4% [0·3-0·6], p=0·17 and p=1·00, respectively). Lung cancer probability was intermediate (requiring follow-up CT) if nodules had a volume of 100-300 mm(3) (2·4% [95% CI 1·7-3·5]) or a diameter 5-10 mm (1·3% [1·0-1·8]). Volume doubling time further stratified the probabilities: 0·8% (95% CI 0·4-1·7) for volume doubling times 600 days or more, 4·0% (1·8-8·3) for volume doubling times 400-600 days, and 9·9% (6·9-14·1) for volume doubling times of 400 days or fewer. Lung cancer probability was high for participants with nodule volumes 300 mm(3) or bigger (16·9% [95% CI 14·1-20·0]) or diameters 10 mm or bigger (15·2% [12·7-18·1]). The simulated ACCP management protocol yielded a sensitivity and specificity of 90·9% (95% CI 81·2-96·1), and 87·2% (86·4-87·9), respectively. A diameter-based protocol with volumetry-based nodule diameter yielded a higher sensitivity (92·4% [95% CI 83·1-97·1]), and a higher specificity (90·0% [89·3-90·7). A volume-based protocol (with thresholds based on lung cancer probability) yielded the same sensitivity as the ACCP protocol (90·9% [95% CI 81·2-96·1]), and a higher specificity (94·9% [94·4-95·4]). Small nodules (those with a volume <100 mm(3) or diameter <5 mm) are not predictive for lung cancer. Immediate diagnostic evaluation is necessary for large nodules (≥300 mm(3) or ≥10 mm). Volume doubling time assessment is advocated only for intermediate-sized nodules (with a volume ranging between 100-300 mm(3) or diameter of 5-10 mm). Nodule management protocols based on these thresholds performed better than the simulated ACCP nodule protocol. Zorgonderzoek Nederland Medische Wetenschappen and Koningin Wilhelmina Fonds. Copyright © 2014 Elsevier Ltd. All rights reserved.

  7. ATES Smart Grids research project overview and first results

    NASA Astrophysics Data System (ADS)

    Bloemendal, Martin; Jaxa-Rozen, Marc; Rostampour, Vahab

    2016-04-01

    ) after which we then incorporate the entire city of Amsterdam (3). The first results of the academic model are promising (Jaxa-Rozen et al., 2015), it shows that stable situations result even for ATES system that are placed a lot closer together than what current regulations would dictate. This has a positive effect on the total GHG emission reduction, but a negative effect on individual efficiency. In the presentation at EGU we will show results from the academic case, discuss several challenges for the optimization and present details on the analytical geohydrological ATES well model required for the controller to keep track of energy losses in its own wells. References • Bakr, M., van Oostrom, N., Sommer, W., 2013. Efficiency of and interference among multiple Aquifer Thermal Energy Storage systems; A Dutch case study. Renewable Energy 60, 53-62. • Bloemendal, M., Olsthoorn, T., Boons, F., 2014. How to achieve optimal and sustainable use of the subsurface for Aquifer Thermal Energy Storage. Energy Policy 66, 104-114. • Bloemendal, M., Olsthoorn, T., van de Ven, F., 2015. Combining climatic and geo-hydrological preconditions as a method to determine world potential for aquifer thermal energy storage. Science of the Total Environment 538 621-633. • CBS, 2015. Hernieuwbare energie in Nederland 2014 (renewable energy in NL). Central authority for statistics in NL, Den Haag. • EU, 2010. Directive on the energy performance of buildings, in: Union, O.J.o.t.E. (Ed.), 153;13-35. EU-Parliament, European Union, Strasbourg. • EU, 2014. A review of factors affecting environmental and economic life-cycle performance for electrically-driven heat pumps, in: Commission, E. (Ed.). • Heekeren, V.v., Bakema, G., 2015. The Netherlands Country Update on Geothermal Energy, World Geothermal Congress, Melbourne. • Jaxa-Rozen, M., Kwakkel, J.H., Bloemendal, M., 2015. The Adoption and Diffusion of Common-Pool Resource-Dependent Technologies: The Case of Aquifer Thermal Energy

  8. Scatterometry

    NASA Astrophysics Data System (ADS)

    Stoffelen, Adrianus Cornelis Maria

    1996-10-01

    Een veelheid aan meteorologische metingen is dagelijks beschikbaar. De meeste van deze waarnemingen bevinden zich echter boven land, en met name windwaarnemingen boven de (Noord Atlantische) oceaan zijn schaars. Bij een westelijke luchtstroming is dit een duidelijke beperking voor de weers- en golfverwachtingen ten behoeve van Nederland. Juist dan is het gevaar voor bijvoorbeeld storm of overstroming het grootst. Ook in het aardse klimaatsysteem speelt de wind aan het oppervlak een grote rol en is de belangrijkste factor voor de aandrijving van de oceaancirculatie. De oceaancirculatie op zijn beurt is cruciaal voor de verschijnselen die samenhangen met bijvoorbeeld El Niño. Dit proefschift gaat over het scatterometer instrument dat vanuit de ruimte, zelfs onder een wolkendek, nauwkeurige en betrouwbare informatie geeft over de wind aan het oceaanoppervlak met een hoge mate van ruimtelijke consistentie. Tijdens de tweede wereldoorlog werden radars aan boord van schepen veelvuldig gebruikt voor de opsporing van vijandige vaartuigen. Hierbij werd vastgesteld dat de detectie slechter werd naarmate de wind aan het zeeoppervlak groter was. Proefondervindelijk was hiermee het principe van een wind scatterometer aangetoond. Al snel ontwikkelde zich dan ook de idee de wind aan het zeeoppervlak te meten met behulp van radar. Vanuit een vliegtuig of een satelliet word dan een microgolfbundel onder een schuine hoek naar het zeeoppervlak gestuurd. De microgolfstraling, met gewoonlijk een golflengte van enkele centimeters, wordt verstrooid aan het ruwe oppervlak, en een klein gedeelte van de uitgezonden puls keert terug naar het detectorgedeelte van de scatterometer. Het fysische fenomeen van belang voor de werking van de scatterometer is de aanwezigheid van zogeheten capillaire gavitatiegolven op het zeeoppervlak. Deze golven hebben een golflengte van enkele centimeters en reageren vrijwel instantaan op de sterkte van de wind. De verstrooiing van microgolven is op zijn beurt