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Sample records for nederlands huisartsen genootschap

  1. 78 FR 26056 - Waterway Suitability Assessment for Expansion of Liquefied Gas Terminals; Nederland, TX

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-03

    ... public dockets in the January 17, 2008, issue of the Federal Register (73 FR 3316). Public meeting: We do... SECURITY Coast Guard Waterway Suitability Assessment for Expansion of Liquefied Gas Terminals; Nederland... Coast Guard regulations, Sunoco Partners Marketing and Terminals has submitted a Letter of Intent and...

  2. [Editing of articles accepted for publication by the Nederlands Tijdschrift voor Geneeskunde].

    PubMed

    Walvoort, H C

    1997-01-01

    The Nederlands Tijdschrift voor Geneeskunde has been publishing medical science in Dutch for 140 years. To bridge the gap between the specialist science and the general medical reader several sections in the accepted papers have to be clarified, simplified and shortened by post acceptance editing. The style and language of the authors is treated with respect. Changes are made if the article does not comply with internationally accepted rules on scientific reporting, if the article can not be understood using currently authoritative general and medical books of reference, and if its language does not comply with generally accepted Dutch rules for grammar and spelling.

  3. [Drug advertising as communication between the pharmaceutical industry and the physician: advertisements for psychotropic drugs in the Dutch medical journal, Nederlands Tijdschrift voor Geneeskunde, 1900-1940].

    PubMed

    van der Hoogte, Arjo Roersch; Pieters, Toine

    2010-01-01

    In this article we explore the historical development of drug advertisements for psychotropic drugs in the leading Dutch medical journal from 1900 to 1940. The advertisements for hypnotics and sedatives, in The Nederlands Tijdschrift voor Geneeskunde (Dutch medical journal) reflected the changes in the vocabulary and image promoted by the pharmaceutical companies. In the first two decades, the advertisements were sober and to the point, and included the trademark, company name, molecular formula and therapeutic properties of the medication. The emphasis was on creating a scientific image of reliable symptom control for the therapeutic drug. In doing so, the ethical drug companies tried (successfully) to distinguish themselves from the producers of patent medicines. Once scientific credibility was established, the form and content of the advertisements changed significantly. In the late 1920s and 1930s drug companies embraced modern advertising techniques, developing a figurative language to address the changing beliefs and practices of Dutch physicians. Instead of promoting therapeutic drugs as safe and scientific, the emphasis was on their effectiveness in comparison to similar drugs. In the process, scientific information was reduced to an indispensable standardized minimum, whereby therapeutic drugs were advertised according to the latest pharmacological taxonomy rather than molecular formulas. The image-making of 'ethical marketing' began during the interwar years when marketers applied modern advertising techniques and infotainment strategies. The scanty black and white informational bulletins transitioned into colourful advertisements. The pharmaceutical companies employed the same medical language as used by physicians, so that one word or image in an advertisement would suffice for the physician to recognize a drug and its therapeutic properties. These developments show the changing relationship between the modern ethical pharmaceutical industry and Dutch

  4. [Drug advertising as communication between the pharmaceutical industry and the physician: advertisements for psychotropic drugs in the Dutch medical journal, Nederlands Tijdschrift voor Geneeskunde, 1900-1940].

    PubMed

    van der Hoogte, Arjo Roersch; Pieters, Toine

    2010-01-01

    In this article we explore the historical development of drug advertisements for psychotropic drugs in the leading Dutch medical journal from 1900 to 1940. The advertisements for hypnotics and sedatives, in The Nederlands Tijdschrift voor Geneeskunde (Dutch medical journal) reflected the changes in the vocabulary and image promoted by the pharmaceutical companies. In the first two decades, the advertisements were sober and to the point, and included the trademark, company name, molecular formula and therapeutic properties of the medication. The emphasis was on creating a scientific image of reliable symptom control for the therapeutic drug. In doing so, the ethical drug companies tried (successfully) to distinguish themselves from the producers of patent medicines. Once scientific credibility was established, the form and content of the advertisements changed significantly. In the late 1920s and 1930s drug companies embraced modern advertising techniques, developing a figurative language to address the changing beliefs and practices of Dutch physicians. Instead of promoting therapeutic drugs as safe and scientific, the emphasis was on their effectiveness in comparison to similar drugs. In the process, scientific information was reduced to an indispensable standardized minimum, whereby therapeutic drugs were advertised according to the latest pharmacological taxonomy rather than molecular formulas. The image-making of 'ethical marketing' began during the interwar years when marketers applied modern advertising techniques and infotainment strategies. The scanty black and white informational bulletins transitioned into colourful advertisements. The pharmaceutical companies employed the same medical language as used by physicians, so that one word or image in an advertisement would suffice for the physician to recognize a drug and its therapeutic properties. These developments show the changing relationship between the modern ethical pharmaceutical industry and Dutch

  5. Zertifikat Niederlaendisch: Examen en getuigschrift Nederlands als vreemde taal (Certificate in Dutch)

    ERIC Educational Resources Information Center

    Beersmans, Frans; Sudhoelter, Juergen

    1976-01-01

    An interim report on preparations for designing an examination in Dutch. The "unit-credit system" proposed by the Council of Europe is being used. The Dutch certificate will be comparable to the certificates given by the British Council and by the People's Universities. Sample portions are given. (Text is in German.) (IFS/WGA)

  6. Zuivere en toegepaste wetenschap in de tropen : biologisch onderzoek aan particuliere proefstations in Nederlands-Indië 1870-1940

    NASA Astrophysics Data System (ADS)

    van der Schoor, W. J.

    2012-04-01

    Most experiment stations originated from the cooperation between entrepreneurs and the government. From the 1890s onwards, the government, together with the well organised colonial entrepreneurs, established research departments for several plantation crops at the Botanical Gardens at Buitenzorg (now Bogor), that eventually became independent experiment stations in the first decades of the twentieth century. By the 1920s, the ‘proefstationswezen’ (experiment station system) numbered some fifteen private experiment stations or sub-stations. After the war, the private experiment stations together with the government experiment stations at Buitenzorg were to provide the backbone of Indonesian agricultural science. Dutch biologists in particular, made a striking plea for pursuing the natural sciences in the tropical colonies. First, they pointed out the scientific importance of the tropics. Secondly, they stressed the role of the natural sciences, in particular biology, as a natural ally of colonial agriculture. Pure science was seen as a leading force for technical and social progress. The third motive was the cultural value of science for the Netherlands and its colonies. The cultivation of science in the colonies gave international prestige and strengthened self-confidence in the imperial struggle around 1900. Science had a civilising effect; scientific research, however, was to remain in the hands of western, colonial scientists. From the 1880s and 1890s onward, the experiment stations in the Indies were characterised by their strategic aims and scientific orientation. Up to 1910, the ‘academic’ views of biologists like Treub and Went concerning science and practice were predominant, and research was considered to be the central aim. From 1910 onwards, advice became more central and special extension services were established at the experiment stations. Due to diverging views of science, tasks and aims became a battlefield for discussions in the next decades. In the background of these debates were the rise of Wageningen Agricultural College, the rise and institutionalisation of applied agricultural sciences and the increasing competition between Wageningen and university trained scientist. Genetics and breeding in particular were at the core of the research programmes. The practical aim of the breeding work, however, did not leave too much opportunity for more fundamental investigations. The impetus for pure research came from individual researchers. In tobacco and sugar cane breeding, new scientific theories provided inspiration, but to a large extent the practical breeding work built on nineteenth-century breeding techniques. In many respects, plant breeding and university genetics became separate disciplines. Circa one in six Dutch biologist worked for at least some time in the colony. The colonial experiment stations instilled a practical and pragmatic attitude to Dutch science into quite a number of biologists. Besides, the experiment stations system provided Dutch biologists with an extensive network and international contacts with fellow scientists, entrepreneurs and captains of industry. The scientific nationalism of Treub and Went, the bloom of the experiment stations and the ambitions of the Indies colonial elite did not result in the establishment of an independent, ‘Indische’ scientific community. Essentially, the Dutch East Indies were an exploitation province of Dutch science

  7. 77 FR 30522 - Sunoco Pipeline L.P., West Texas Gulf Pipe Line Company, Mobil Pipe Line Company; Notice of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-23

    ...://www.ferc.gov . To facilitate electronic service, persons with Internet access who will eFile a... structure for the proposed West Texas--Nederland Access Project. Any person desiring to intervene or...

  8. 76 FR 20363 - Accreditation and Approval of Camin Cargo Control, Inc., as a Commercial Gauger and Laboratory

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-12

    ... Control, Inc., 1550 Industrial Park Drive, Nederland, TX 77627, has been approved to gauge and accredited... 19 CFR 151.12 and 19 CFR 151.13. Anyone wishing to employ this entity to conduct laboratory...

  9. Wind in the Willows--Theatre Activity Packet.

    ERIC Educational Resources Information Center

    New York City Board of Education, Brooklyn, NY. Div. of Curriculum and Instruction.

    Part of the New York City Board of Education's Early Stages program, and intended for elementary and secondary school teachers who wish to include a unit on theater in their classes, this guide offers suggestions for lessons and activities to accompany viewing a performance of "Wind in the Willows" at the Nederlander Theater. Part one of the guide…

  10. Communicating Astronomy with a Mass Audience — BBC's Stargazing Live goes Dutch

    NASA Astrophysics Data System (ADS)

    Baan, M.

    2015-06-01

    Following on from the hugely successful airing of Heel Nederland Kijkt Sterren — a Dutch stargazing event modelled on the BBC's programme Stargazing Live — this article explores some of the issues involved in communicating astronomy directly to a mass audience. This includes the production process, co-sponsorship, content, the reach and lessons learned.

  11. OpenER, a Dutch Initiative in Open Educational Resources

    ERIC Educational Resources Information Center

    Schuwer, Robert; Mulder, Fred

    2009-01-01

    Over the period 2006-2008, the Dutch Open Universiteit Nederland conducted an experiment in which Open Educational Resources (OER) were offered in an effort to bridge the gap between informal and formal learning and to establish a new style of entry portal to higher education with no barriers at all. OpenER received considerable attention both in…

  12. Implementation of an Evidence-Based Guideline for the Referral of Adults Who Are Visually Impaired in the Netherlands: Potential Barriers

    ERIC Educational Resources Information Center

    Cruysberg, Juliette K.; van Rens, Ger H. M. B.

    2007-01-01

    This article reports on a study on the implementation of an evidence-based guideline for the referral for rehabilitation of adults who are visually impaired in the Netherlands. The purpose of the study was to find out if there are potential barriers to the implementation of the Nederlands Oogheelkundig Gezelschap (NOG) (2004) evidence-based…

  13. 76 FR 64963 - Accreditation and Approval of Intertek USA, Inc., as a Commercial Gauger and Laboratory

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-19

    ... service requested. Alternatively, inquiries regarding the specific test or gauger service this entity is...., 2780 Highway 69 N, Nederland, TX 77627, has been approved to gauge and accredited to test petroleum and... analyses and gauger services should request and receive written assurances from the entity that it...

  14. Documenting Living Monuments in Indonesia: Methodology for Sustainable Utility

    NASA Astrophysics Data System (ADS)

    Suryaningsih, F.; Purwestri, N.

    2013-07-01

    The systematic documentation of cultural heritage in Indonesia has been developed after the establishment of Bataviaasch Genootschap van Kunsten en Wetenschappen (1778) and De Oudheidkundige Dienst (1913) by the Netherlands Indies government. After Indonesian independent, the tasks of cultural heritage documentation take over by The Ministry of Culture (now become The Ministry of Education of Culture) with focus on the ancient and classical heritage, so called dead monument. The needed of comprehensive documentation data regarding cultural heritage become significant issues since the government and private sector pay attention to the preservation of heritage building in the urban site, so called living monument. The archives of original drawing plan many times do not fit with the existing condition, while the conservation plan demands a document such as built drawing plan to work on. The technology, methodology and system to provide such comprehensive document of heritage building and site become important, to produce good conservation plan and heritage building regular maintenance. It means the products will have a sustainable and various utility values. Since 1994, Documentation Centre for Architecture - Indonesia (PDA), has established to meet the needs of a comprehensive data of heritage building (living monuments), to utilized as basic document for conservation planning. Not only provide document of the digital drawing such site plan, plan, elevation, section and details of architecture elements, but also document of historic research, material analysis and completed with diagnosis and mapping of building damages. This manuscript is about PDA field experience, working in this subject issue

  15. "A bare outpost of learned European culture on the edge of the jungles of Java": Johan Maurits Mohr (1716-1775) and the emergence of instrumental and institutional science in Dutch Colonial Indonesia

    NASA Astrophysics Data System (ADS)

    Zuidervaart, Huib J.; van Gent, Robert H.

    2004-03-01

    The transits of Venus in 1761 and 1769 appear to mark the starting point of instrumental science in the Dutch East Indies (now Indonesia). This essay examines the conditions that triggered and constituted instrumental and institutional science on Indonesian soil in the late eighteenth century. In 1765 the Reverend J. M. Mohr, whose wife had received a large inheritance, undertook to build a fully equipped private observatory in Batavia (now Jakarta). There he made several major astronomical and meteorological observations. Mohr's initiative inspired other Europeans living on Java around 1770 to start a scientific movement. Because of the lack of governmental and other support, it was not until 1778 that this offspring of the Dutch-Indonesian Enlightenment became a reality. The Bataviaasch Genootschap van Kunsten en Wetenschappen tried from the beginning to put into effect the program Mohr had outlined. The members even bought his instruments from his widow, intending to continue his measurements. For a number of reasons, however, this instrumental program was more than the society could support. Around 1790 instrumental science in the former Dutch East Indies came to a standstill, not to be resumed for several decades.

  16. Evaluation of the Netherlands' International Test Facility for Smart Grids

    SciTech Connect

    Palmintier, Bryan; Pratt, Annabelle

    2015-06-01

    The Netherlands Enterprise Agency (Rijksdienst voor Ondernemend Nederland, or RVO) engaged the U.S. National Renewable Energy Laboratory (NREL) for two primary purposes: to evaluate the International Test Facility for Smart Grids (ITF) sponsored by RVO and to learn best practices for integrated test facilities from NREL's Energy Systems Integration Facility (ESIF). This report covers the ITF evaluation and is largely based on a one-week visit to the Netherlands in November 2014.

  17. AmeriFlux US-NR1 Niwot Ridge Forest (LTER NWT1)

    DOE Data Explorer

    Blanken, Peter [University of Colorado

    2016-01-01

    This is the AmeriFlux version of the carbon flux data for the site US-NR1 Niwot Ridge Forest (LTER NWT1). Site Description - The Niwot Ridge AmeriFlux site is located in a subalpine forest ecosystem just below the Continental Divide near Nederland, CO. The site is located at 3050 m elevation, within 600m of the NOAA C1 long-term monitoring station, approximately 8 km east of the Continental Divide. The surrounding subalpine forest is ~97 years old and in a state of aggradation, having recovered from early twentieth century logging (Monson, et al. Global Change Biology (2002), 8 459-478).

  18. [The gift of pharmacopoeias made by Mésaize to the Society of Pharmacists of Rouen].

    PubMed

    Lafont, Olivier; Vettes, Jules

    2015-12-01

    Pierre-Grégoire Mésaize, a pharmacist of Rouen made an important gift to the Society of pharmacists of Rouen in 1831. 21 Books, mainly foreign pharmacopoeias, constituted this gift. Six were from Germany; five came from United Kingdom, three from Nederland, only two from France, and one from Belgium, one from Switzerland, one from Austria and one from Russia. This diversity of origins was quite informative about the quality of the content of pharmacists' libraries in Rouen at the beginning of the 19th century. Unfortunately these books could not be found nowadays in the Library of the Union of pharmacists of Seine-Maritime. PMID:26827548

  19. The hovercraft environment.

    PubMed

    Lovesey, E J

    1970-06-01

    In just over a decade the hovercraft has progressed from first prototype to a successful commercial form of transport which also has the ability to penetrate many environments hitherto virtually inaccessible to manned vehicles. Comparison with rival short range vehicles such as the helicopter and hydrofoil show that the hovercraft has become one of the most versatile forms of transport available. This versatility and ability to operate in unusual or extreme environments has been accompanied by the problems of control and of protection of the occupants of the hovercraft from the hazards associated with these environments. Several of these problems are discussed, together with their possible solutions. This article is based on a paper given to the Nederlands Vereniging Voor Ergonomie/Ergonomics Research Society joint conference at Noordwijk in Holland, 11-13 June, 1969. PMID:15676324

  20. A hidden pygmy devil from the Philippines: Arulenus miae sp. nov.-a new species serendipitously discovered in an amateur Facebook post
    (Tetrigidae: Discotettiginae).

    PubMed

    Skejo, Josip; Caballero, Joy Honezza S

    2016-01-01

    Arulenus miae Skejo & Caballero sp. nov. is described from Buknidon and Davao, Mindanao, the Philippines. The species was serendipitously found in an amateur photo posted in Orthoptera Facebook group by Leif Gabrielsen. Holotype and paratype are deposited in Nederlands Centrum voor Biodiversiteit in Leiden, the Netherlands. Detailed comparison with Arulenus validispinus Stål, 1877 is given. A new diagnosis of the genus and A. validispinus is given. The paper is part of the revision of the subfamily Discotettiginae. This study provides a good example of how social networks can be used as a modern tool of discovering biodiversity if the regulations of the International Code of the Zoological Nomenclature are followed. A brief insight into habitat and ecology of this rainforest and mountainous species is presented. PMID:27395882

  1. TOD characterization of the Gatekeeper electro-optical security system

    NASA Astrophysics Data System (ADS)

    Gosselink, Guido; Anbeek, Hugo; Bijl, Piet; Hogervorst, Maarten A.

    2013-06-01

    The Triangle Orientation Discrimination (TOD) test method was applied to characterize thermal and visual range performance of the Gatekeeper Electro Optical Security System. Gatekeeper developed by Thales Nederland BV, is currently in use with the Royal Netherlands Navy. The system houses uncooled infrared and colour TV cameras providing up to 360° view in azimuth. The images displayed to the operator are automatically optimized based on the scene intensity distribution. Because of this built-in scene-based optimization, proper measurement of the system requires careful surround illumination of the TOD setup over a large part of the camera Field Of View. The tests provided very accurate threshold estimates with relatively small observer differences. The resulting TOD curves that characterize the sensor system in terms of acuity and contrast sensitivity can be used as input to a Target Acquisition model to predict range performance for operational scenarios.

  2. Development of advanced concepts for DIR-MCFC cogeneration applications in the European Market

    SciTech Connect

    Kortbeek, P.J.; Ottervanger, R.G.; Dicks, A.L.

    1996-12-31

    Early 1996 a three year (1996 - 1998) joint European project was launched under the name {open_quote}Advanced DIR-MCFC Development{close_quote}, aiming at the development of Direct Internal Reforming (DIR) Molten Carbonate Fuel Cell (MCFC) systems for cogeneration applications for the European market. In this project participate: Brandstofcel Nederland BV (BCN), British Gas pic (BG), Gaz de France (GDF), Netherlands Energy Research foundation (ECN), Stork, Royal Schelde and Sydkraft AB. The European Fuel Cell User Group (EFCUG) supports the project as an advisory board. Whereas the US and Japanese programmes are aimed at large-scale demonstrations of the MCFC technology, this project focusses on the development of concepts and technology, required for MCFC systems that will be competative on the cogeneration market. The project partners provide the essential expertise: from end-user, system engineering, stack development up to fundamental material research.

  3. AIV Platform for the Galileo Precise Timing Facility

    NASA Astrophysics Data System (ADS)

    Oving, B. A.; Kroon, E.

    2008-08-01

    The Precise Timing Facility (PTF) is an element of the Galileo Ground Mission Segment (GMS) and is responsible for maintaining and distributing the Galileo System Time (GST). The PTF is based on a set of Caesium clocks and Active Hydrogen Maser clocks, the combination of which should be able to provide the required precision and stability of the GST. As the PTF is a critical element within the GMS, diversity is applied in that two PTFs are made by two different companies. The subject of this paper is the PTF that is being developed by Kayser-Threde. To perform the Assembly, Integration and Verification (AIV) activities of the PTF, a dedicated test platform, PTF-AIVP, is developed by the National Aerospace Laboratory, NLR (the Netherlands) and the Nederlands Meetinstituut (NMi). The PTF-AIVP will be used to measure and analyse the (physical) output of the PTF, so that the stringent precision and stability requirements can be verified. Furthermore, it will simulate other Elements in the GMS that are connected to the PTF.

  4. The governance of quality management in dutch health care: new developments and strategic challenges.

    PubMed

    Maarse, J A M; Ruwaard, D; Spreeuwenberg, C

    2013-01-01

    This article gives a brief sketch of quality management in Dutch health care. Our focus is upon the governance of guideline development and quality measurement. Governance is conceptualized as the structure and process of steering of quality management. The governance structure of guideline development in the Netherlands can be conceptualized as a network without central coordination. Much depends upon the self-initiative of stakeholders. A similar picture can be found in quality measurement. Special attention is given to the development of care standards for chronic disease. Care standards have a broader scope than guidelines and take an explicit patient perspective. They not only contain evidence-based and up-to-date guidelines for the care pathway but also contain standards for self-management. Furthermore, they comprise a set of indicators for measuring the quality of care of the entire pathway covered by the standard. The final part of the article discusses the mission, tasks and strategic challenges of the newly established National Health Care Institute (Zorginstituut Nederland), which is scheduled to be operative in 2013.

  5. Inducing Expectations for Health: Effects of Verbal Suggestion and Imagery on Pain, Itch, and Fatigue as Indicators of Physical Sensitivity

    PubMed Central

    Peerdeman, Kaya J.; van Laarhoven, Antoinette I. M.; Donders, A. Rogier T.; Hopman, Maria T. E.; Peters, Madelon L.; Evers, Andrea W. M.

    2015-01-01

    Research into placebo effects has convincingly shown that inducing positive outcome expectations can reduce pain and other physical sensations. However, the comparative effects of different expectation inductions, such as verbal suggestion or mental imagery, and their generic effects on physical sensitivity, to different sensations such as pain, itch, and fatigue, are still largely unknown. In the current study, we assessed the individual and combined effects of verbal suggestion and imagery on pain, itch, and fatigue as indicators of physical sensitivity in a randomized study design. Healthy participants (n = 116) were given an inert (placebo) capsule that was said to be effective for reducing physical sensitivity in either the majority (positive verbal suggestion) or the minority (control verbal suggestion) of users. Subsequently, they imagined either their best possible health (positive imagery) or a typical day (control imagery). Sensitivity to pain, itch, and fatigue was tested using a cold pressor test, histamine iontophoresis, and a bicycle test, respectively. Heart rate and skin conductance were recorded continuously. Results showed that positive verbal suggestion and imagery successfully induced positive expectations, but they did not affect physical sensitivity, as indicated by sensitivity to pain, itch, or fatigue, or concurrent physiological responses. These results could indicate that the specificity and concreteness of expectation inductions might be important for their applicability in the treatment of physical symptoms. Trial Registration Nederlands Trial Register NTR3641 PMID:26448183

  6. The meaning of "significance" for different types of research [translated and annotated by Eric-Jan Wagenmakers, Denny Borsboom, Josine Verhagen, Rogier Kievit, Marjan Bakker, Angelique Cramer, Dora Matzke, Don Mellenbergh, and Han L. J. van der Maas]. 1969.

    PubMed

    de Groot, A D

    2014-05-01

    Adrianus Dingeman de Groot (1914-2006) was one of the most influential Dutch psychologists. He became famous for his work "Thought and Choice in Chess", but his main contribution was methodological--De Groot co-founded the Department of Psychological Methods at the University of Amsterdam (together with R. F. van Naerssen), founded one of the leading testing and assessment companies (CITO), and wrote the monograph "Methodology" that centers on the empirical-scientific cycle: observation-induction-deduction-testing-evaluation. Here we translate one of De Groot's early articles, published in 1956 in the Dutch journal Nederlands Tijdschrift voor de Psychologie en Haar Grensgebieden. This article is more topical now than it was almost 60years ago. De Groot stresses the difference between exploratory and confirmatory ("hypothesis testing") research and argues that statistical inference is only sensible for the latter: "One 'is allowed' to apply statistical tests in exploratory research, just as long as one realizes that they do not have evidential impact". De Groot may have also been one of the first psychologists to argue explicitly for preregistration of experiments and the associated plan of statistical analysis. The appendix provides annotations that connect De Groot's arguments to the current-day debate on transparency and reproducibility in psychological science.

  7. Self-Shielding Correlation of Foil Activation Neutron Spectra Analysis by SAND-II.

    2008-11-21

    Version 00 SELFS-3 corrects for the influence of the self-shielding effect in neutron spectrum determinations by means of the multifoil activation method. It is used in combination with the SAND-II program for unfolding the responses of an irradiated set of activation detectors in 620 groups. The program SELFS can calculate a corrected 620 group cross section data set for specified reactions used in the SAND-II library, and for specified foil thicknesses. This procedure requires nomore » additional assumption on the shape of the neutron spectrum and on other experimental conditions, but only some foil characteristics (reaction type, material composition, foil thickness). Application of this procedure is possible when multigroup unfolding programs are used with suitably small energy intervals. This code system was developed in the 1970’s at Reactor Centrum Nederland, Petten, The Netherlands, and was contributed to RSICC through the NEA Data Bank. No changes were made to the package when it was released by RSICC in 2008. Modifications will be required to run SELFS-3 on current computer systems.« less

  8. [Incidence of various disorders in fattening pigs and their effects on growth and carcass quality].

    PubMed

    van Dijk, W P; Klaver, J; Verstegen, M W

    1984-07-01

    Findings in 6,304 fattening pigs at the experimental piggery 'Zuid-West Nederland' in Sterksel were used to study the incidence of tail-biting, leg disorders, cough and diarrhoea. The majority of animals were fed ad libitum and housed on completely or partially slatted floors. Approximately 20 per cent of the animals were treated for various conditions. The appearance of these conditions was associated with a decrease in rate of gain of 10-67 g day-1 animal-1. Carcass grading was also reduced in the animals, which had been treated for affections. Tail-biting and diarrhoea were the two most common conditions. The majority of conditions occurred mainly during the first eighty days of the fattening period. However, a higher relative proportion of animals were treated for cough during the last fourty days of the fattening period. Leg-disorders affected the rate of gain more than did the other conditions. The rate of gain was reduced by 67 g day-1 animal-1 and carcass grading by 11 per cent. The conditions were associated with considerable loss in production traits (gain and carcass grading). PMID:6463998

  9. Design review for Strategic Petroleum Reserve office, Big Hill, Texas, New Orleans, Louisiana

    SciTech Connect

    Not Available

    1984-02-01

    The Big Hill Strategic Petroleum Reserve storage site is designed to store 140 million barrels of oil in underground storage caverns. The major facilities of the Big Hill Strategic Petroleum Reserve storage site are: the main operations area; the storage cavern area; the Raw Water Intake Structure at the Intracoastal Waterway; the raw water pipeline between the Big Hill operations area and Raw Water Intake Structure; the brine disposal pipeline from the Big Hill complex to 3-1/2 miles into the Gulf of Mexico; and, the crude oil pipeline between the Sunoco Terminals in Nederland and Big Hill Complex. These facilities are designed to solution mine the storage caverns from naturally occurring salt domes below the Big Hill complex site, as well as, to transport the crude oil in and out of the caverns to/from the Sunoco Terminals. Bechtel Petroleum, Inc. through Bechtel Advanced Technologies has been engaged to conduct a review of the design of the Big Hill facilities. The purpose of this design review is to audit design and construction documents to: ensure that the design complies with established design criteria; ensure the constructability of the design; and ensure that the interfaces between the construction packages are adequate. To this end, Bechtel was provided with construction contract packages, most design calculations and various pre-design documents. A summary of the scope of each contract package can be found on Table I.

  10. [Reporting of scientific misconduct in health care research].

    PubMed

    Klasen, E C; Overbeke, A J P M

    2002-08-31

    The incidence of scientific dishonesty in the Netherlands is not known, yet experiences at both the NWO (the Netherlands Organization for Scientific Research) and Nederlands Tijdschrift voor Geneeskunde (Dutch Journal of Medicine) indicate that there must be several cases per year. For scientific fraud to be prevented students and researchers should receive thorough teaching, and in research laboratories an emphasis should be placed upon integrity. The Academic Medical Centre in Amsterdam has published a research protocol which is perfect for internal use. The Royal Netherlands Academy of Arts and Sciences publishes brochures on good research practice for researchers, teachers and students. The NWO and the Vereniging van Universiteiten (Dutch Association of Universities) have set up a committee for scientific integrity to function as a fallback mechanism and to assess the institutional procedures or to repeat the inquiries. As healthcare research institutions other than universities are involved since authorities are not always objective, an independent committee has been established to assess complaints about scientific dishonesty, the Scientific Integrity Health Research. Like the Committee on Publication Ethics it will publish its cases anonymously on an annual basis. Its judgments will be communicated to the people involved and the proper authorities.

  11. Additional value of computer assisted semen analysis (CASA) compared to conventional motility assessments in pig artificial insemination.

    PubMed

    Broekhuijse, M L W J; Soštarić, E; Feitsma, H; Gadella, B M

    2011-11-01

    In order to obtain a more standardised semen motility evaluation, Varkens KI Nederland has introduced a computer assisted semen analysis (CASA) system in all their pig AI laboratories. The repeatability of CASA was enhanced by standardising for: 1) an optimal sample temperature (39 °C); 2) an optimal dilution factor; 3) optimal mixing of semen and dilution buffer by using mechanical mixing; 4) the slide chamber depth, and together with the previous points; 5) the optimal training of technicians working with the CASA system; and 6) the use of a standard operating procedure (SOP). Once laboratory technicians were trained in using this SOP, they achieved a coefficient of variation of < 5% which was superior to the variation found when the SOP was not strictly used. Microscopic semen motility assessments by eye were subjective and not comparable to the data obtained by standardised CASA. CASA results are preferable as accurate continuous motility dates are generated rather than discrimination motility percentage increments of 10% motility as with motility estimation by laboratory technicians. The higher variability of sperm motility found with CASA and the continuous motility values allow better analysis of the relationship between semen motility characteristics and fertilising capacity. The benefits of standardised CASA for AI is discussed both with respect to estimate the correct dilution factor of the ejaculate for the production of artificial insemination (AI) doses (critical for reducing the number of sperm per AI doses) and thus to get more reliable fertility data from these AI doses in return.

  12. Development of a Solar Array Drive Assembly for CubeSat

    NASA Technical Reports Server (NTRS)

    Passaretti, Mike; Hayes, Ron

    2010-01-01

    Small satellites and in particular CubeSats, have increasingly become more viable as platforms for payloads typically requiring much larger bus structures. As advances in technology make payloads and instruments for space missions smaller, lighter and more power efficient, a niche market is emerging from the university community to perform rapidly developed, low-cost missions on very small spacecraft - micro, nano, and picosatellites. In just the last few years, imaging, biological and new technology demonstration missions have been either proposed or have flown using variations of the CubeSat structure as a basis. As these missions have become more complex, and the CubeSat standard has increased in both size (number of cubes) and mass, available power has become an issue. Body-mounted solar cells provide a minimal amount of power; deployable arrays improve on that baseline but are still limited. To truly achieve maximum power, deployed tracked arrays are necessary. To this end, Honeybee Robotics Spacecraft Mechanisms Corporation, along with MMA of Nederland Colorado, has developed a solar array drive assembly (SADA) and deployable solar arrays specifically for CubeSat missions. In this paper, we discuss the development of the SADA.

  13. The EUMETSAT ocean and sea ice SAF (OSI SAF) : Overview on the project and the products

    NASA Astrophysics Data System (ADS)

    Guevel, Guenole

    The EUMETSAT OSI SAF (www.osi-saf.org) was created in 1997 as an answer to requirements for a comprehensive information derived from meteorological satellites at the ocean-atmosphere interface. The OSI SAF consortium is constituted of Météo-France as leading entity, and Met.no (Norske ee Meteorologiske Institutt), DMI (Danish Meteorological Institute), SMHI (Swedish Meteorolog-ical and Hydrological Institute), KNMI (Koninklijk Nederlands Meteorologisch Instituut) and IFREMER (Institut Français de Recherche pour l'Exploitation de la MER) as co-operating c entities. The two previous phases of the EUMETSAT Ocean and Sea Ice Satellite Application Facility (OSI SAF), the Development phase (1997-2002) and the IOP (initial Operations Phase, 2002-2007) met the main target which was to develop, validate and then produce operationally quality controlled satellite-derived products related to four key parameters of the sea surface (Sea Surface Temperature, Radiative Fluxes, Sea Ice, Wind) over various geographical coverage from regional to global. These products are currently available in near real time both through EUMETCAST and local FTP servers, and off line from local archive. Archiving at EUMETSAT Data Center is also being implemented. The current phase of the EUMETSAT OSI SAF, the CDOP (Continuous Development and Operations Phase, 2007-2012) has taken into account new requirements expressed in particular in the context of GODAE, GHRSST and GCOS at international level, and GMES (through MyOcean) at European level, with in particular a strong need for increasing the temporal and geographical resolution of the products and user friendly interfaces allowing access to high level allowing flexible extraction An overview on the OSI SAF project and its current and future production in the time frame of the CDOP will be presented, as well as first glance on the following phase, the CDOP-2, that will cover 2012 to 2017.

  14. Feasibility of portal dosimetry for flattening filter-free radiotherapy.

    PubMed

    Chuter, Robert W; Rixham, Philip A; Weston, Steve J; Cosgrove, Vivian P

    2016-01-08

    The feasibility of using portal dosimetry (PD) to verify 6 MV flattening filter-free (FFF) IMRT treatments was investigated. An Elekta Synergy linear accelerator with an Agility collimator capable of delivering FFF beams and a standard iViewGT amorphous silicon (aSi) EPID panel (RID 1640 AL5P) at a fixed SSD of 160 cm were used. Dose rates for FFF beams are up to four times higher than for conventional flattened beams, meaning images taken at maximum FFF dose rate can saturate the EPID. A dose rate of 800 MU/min was found not to saturate the EPID for open fields. This dose rate was subsequently used to characterize the EPID for FFF portal dosimetry. A range of open and phantom fields were measured with both an ion chamber and the EPID, to allow comparison between the two. The measured data were then used to create a model within The Nederlands Kanker Instituut's (NKI's) portal dosimetry software. The model was verified using simple square fields with a range of field sizes and phantom thicknesses. These were compared to calculations performed with the Monaco treatment planning system (TPS) and isocentric ion chamber measurements. It was found that the results for the FFF verification were similar to those for flattened beams with testing on square fields, indicating a difference in dose between the TPS and portal dosimetry of approximately 1%. Two FFF IMRT plans (prostate and lung SABR) were delivered to a homogeneous phantom and showed an overall dose difference at isocenter of ~0.5% and good agreement between the TPS and PD dose distributions. The feasibility of using the NKI software without any modifications for high-dose-rate FFF beams and using a standard EPID detector has been investigated and some initial limitations highlighted.

  15. Web-based self-management with and without coaching for type 2 diabetes patients in primary care: design of a randomized controlled trial

    PubMed Central

    2013-01-01

    Background Self-management is recognized as the cornerstone of overall diabetes management. Web-based self-management programs have the potential of supporting type 2 diabetes patients with managing their diabetes and reducing the workload for the care provider, where the addition of online coaching could improve patient motivation and reduce program attrition. This study aims to test the hypothesis that a web-based self-management program with coaching will prove more effective on improving patient self-management behavior and clinical outcome measures than a web-based self-management program without coaching. Methods The effects of a web-based self-management program with and without coaching will be tested with a nested randomized controlled trial within a healthcare group in the Netherlands. In one year 220 type 2 diabetes patients will be randomized into an intervention group (n = 110) or a control group (n = 110). The control group will receive only the online self-management program. The intervention group will receive the online self-management program and additional online coaching. Participants will be followed for one year, with follow-up measurements at 6 and 12 months. Discussion The intervention being tested is set to support type 2 diabetes patients with their diabetes self-management and is expected to have beneficial effects on self-care activities, well being and clinical outcomes. When proven effective this self-management support program could be offered to other health care groups and their type 2 diabetes patients in the Netherlands. Trial registration Nederlands Trial Register NTR4064 PMID:24238104

  16. A Cluster-Randomized Trial of Two Strategies to Improve Antibiotic Use for Patients with a Complicated Urinary Tract Infection

    PubMed Central

    Spoorenberg, Veroniek; Hulscher, Marlies E. J. L.; Geskus, Ronald B.; de Reijke, Theo M.; Opmeer, Brent C.; Prins, Jan M.; Geerlings, Suzanne E.

    2015-01-01

    Background Up to 50% of hospital antibiotic use is inappropriate and therefore improvement strategies are urgently needed. We compared the effectiveness of two strategies to improve the quality of antibiotic use in patients with a complicated urinary tract infection (UTI). Methods In a multicentre, cluster-randomized trial 19 Dutch hospitals (departments Internal Medicine and Urology) were allocated to either a multi-faceted strategy including feedback, educational sessions, reminders and additional/optional improvement actions, or a competitive feedback strategy, i.e. providing professionals with non-anonymous comparative feedback on the department’s appropriateness of antibiotic use. Retrospective baseline- and post-intervention measurements were performed in 2009 and 2012 in 50 patients per department, resulting in 1,964 and 2,027 patients respectively. Principal outcome measures were nine validated guideline-based quality indicators (QIs) that define appropriate antibiotic use in patients with a complicated UTI, and a QI sumscore that summarizes for each patient the appropriateness of antibiotic use. Results Performance scores on several individual QIs showed improvement from baseline to post-intervention measurements, but no significant differences were found between both strategies. The mean patient’s QI sum score improved significantly in both strategy groups (multi-faceted: 61.7% to 65.0%, P = 0.04 and competitive feedback: 62.8% to 66.7%, P = 0.01). Compliance with the strategies was suboptimal, but better compliance was associated with more improvement. Conclusion The effectiveness of both strategies was comparable and better compliance with the strategies was associated with more improvement. To increase effectiveness, improvement activities should be rigorously applied, preferably by a locally initiated multidisciplinary team. Trial Registration Nederlands Trial Register 1742 PMID:26637169

  17. Neurocinematography in Pre-World War II Netherlands: The Magnus-Rademaker Collection.

    PubMed

    Koehler, Peter J; Lameris, Bregt; Hielscher, Eva

    2016-01-01

    Historical films made by neuroscientists have shown up in several countries during past years. Although originally supposed to have been lost, we recently found a collection of films produced between 1909 and 1940 by Rudolf Magnus (1873-1927), professor of pharmacology (Utrecht) and his student Gysbertus Rademaker (1887-1957), professor of physiology (1928, succeeding Willem Einthoven) and neurology (1945, both in Leiden). Both collections deal with the physiology of body posture by the equilibrium of reflex musculature contractions for which experimental studies were done with animals (labyrinthectomies, cerebellectomies, and brainstem sections) and observations on patients. The films demonstrate the results of these studies. Moreover, there are films with babies showing tonic neck reflexes and moving images capturing adults with cerebellar symptoms following cerebellectomies for tumors and several other conditions. Magnus' studies resulted in his well-known Körperstellung (1924, "Body Posture") and Rademaker's research in his Das Stehen (1931, "Standing"). The films probably had an educative and scientific purpose. Magnus demonstrated his films at congresses, including the Eighth International Congress of Physiologists (Vienna, 1910) and Rademaker screened his moving images at meetings of the Amsterdam Neurologists Society (at several occasions as reflected in the Winkler-Monakow correspondence and the Nederlands Tijdschrift voor Geneeskunde). Next to these purposes, the films were used to analyze movement and a series of images from the films were published in articles and books. The films are important historical sources that provide a portrait of the pre-World War II era in neuroscience, partly answering questions on how physicians dealt with patients and researchers with their laboratory animals. Moreover, the films confirm that cinematography was an important scientific tool in neuroscience research. PMID:26684426

  18. Qualitative Treatment-Subgroup Interactions in a Randomized Clinical Trial of Treatments for Adolescents with ADHD: Exploring What Cognitive-Behavioral Treatment Works for Whom

    PubMed Central

    Geurts, Hilde M.; Prins, Pier J. M.; Van Mechelen, Iven; Van der Oord, Saskia

    2016-01-01

    Objective This study explored qualitative treatment-subgroup interactions within data of a RCT with two cognitive behavioral treatments (CBT) for adolescents with ADHD: a planning-focused (PML) and a solution-focused CBT (SFT). Qualitative interactions imply that which treatment is best differs across subgroups of patients, and are therefore most relevant for personalized medicine. Methods Adolescents with ADHD (N = 159) received either PML or SFT. Pre-, post- and three-month follow-up data were gathered on parent-rated ADHD symptoms and planning problems. Pretreatment characteristics were explored as potential qualitative moderators of pretest to follow-up treatment effects, using an innovative analyses technique (QUINT; Dusseldorp & Van Mechelen, 2014). In addition, qualitative treatment-subgroup interactions for the therapeutic changes from pre- to posttest and from post- to follow-up test were investigated. Results For the entire time span from pretest to follow-up only a quantitative interaction was found, while from posttest to follow-up qualitative interactions were found: Adolescents with less depressive symptoms but more anxiety symptoms showed more improvement when receiving PML than SFT, while for other adolescents the effects of PML and SFT were comparable. Discussion Whereas subgroups in both treatments followed different trajectories, no subgroup was found for which SFT outperformed PML in terms of the global change in symptoms from pretest to three months after treatment. This implies that, based on this exploratory study, there is no need for personalized treatment allocation with regard to the CBTs under study for adolescents with ADHD. However, for a subgroup with comorbid anxiety symptoms but low depression PML clearly appears the treatment of preference. Trial Registration Nederlands Trial Register NTR2142 PMID:26977602

  19. Using Patient Experiences on Dutch Social Media to Supervise Health Care Services: Exploratory Study

    PubMed Central

    Engelen, Lucien JLPG; Verhoef, Lise M; van der Weide, Marian JA; Schoonhoven, Lisette; Kool, Rudolf B

    2015-01-01

    Background Social media has become mainstream and a growing number of people use it to share health care-related experiences, for example on health care rating sites. These users’ experiences and ratings on social media seem to be associated with quality of care. Therefore, information shared by citizens on social media could be of additional value for supervising the quality and safety of health care services by regulatory bodies, thereby stimulating participation by consumers. Objective The objective of the study was to identify the added value of social media for two types of supervision by the Dutch Healthcare Inspectorate (DHI), which is the regulatory body charged with supervising the quality and safety of health care services in the Netherlands. These were (1) supervision in response to incidents reported by individuals, and (2) risk-based supervision. Methods We performed an exploratory study in cooperation with the DHI and searched different social media sources such as Twitter, Facebook, and healthcare rating sites to find additional information for these incidents and topics, from five different sectors. Supervision experts determined the added value for each individual result found, making use of pre-developed scales. Results Searches in social media resulted in relevant information for six of 40 incidents studied and provided relevant additional information in 72 of 116 cases in risk-based supervision of long-term elderly care. Conclusions The results showed that social media could be used to include the patient’s perspective in supervision. However, it appeared that the rating site ZorgkaartNederland was the only source that provided information that was of additional value for the DHI, while other sources such as forums and social networks like Twitter and Facebook did not result in additional information. This information could be of importance for health care inspectorates, particularly for its enforcement by risk-based supervision in care of

  20. Cervical dystonia: effectiveness of a standardized physical therapy program; study design and protocol of a single blind randomized controlled trial

    PubMed Central

    2013-01-01

    physical therapy program forms the basis for a national treatment guideline for cervical dystonia. Trial registration Number Dutch Trial registration (Nederlands Trial Register): NTR3437 PMID:23855591

  1. Feasibility of portal dosimetry for flattening filter-free radiotherapy.

    PubMed

    Chuter, Robert W; Rixham, Philip A; Weston, Steve J; Cosgrove, Vivian P

    2016-01-01

    The feasibility of using portal dosimetry (PD) to verify 6 MV flattening filter-free (FFF) IMRT treatments was investigated. An Elekta Synergy linear accelerator with an Agility collimator capable of delivering FFF beams and a standard iViewGT amorphous silicon (aSi) EPID panel (RID 1640 AL5P) at a fixed SSD of 160 cm were used. Dose rates for FFF beams are up to four times higher than for conventional flattened beams, meaning images taken at maximum FFF dose rate can saturate the EPID. A dose rate of 800 MU/min was found not to saturate the EPID for open fields. This dose rate was subsequently used to characterize the EPID for FFF portal dosimetry. A range of open and phantom fields were measured with both an ion chamber and the EPID, to allow comparison between the two. The measured data were then used to create a model within The Nederlands Kanker Instituut's (NKI's) portal dosimetry software. The model was verified using simple square fields with a range of field sizes and phantom thicknesses. These were compared to calculations performed with the Monaco treatment planning system (TPS) and isocentric ion chamber measurements. It was found that the results for the FFF verification were similar to those for flattened beams with testing on square fields, indicating a difference in dose between the TPS and portal dosimetry of approximately 1%. Two FFF IMRT plans (prostate and lung SABR) were delivered to a homogeneous phantom and showed an overall dose difference at isocenter of ~0.5% and good agreement between the TPS and PD dose distributions. The feasibility of using the NKI software without any modifications for high-dose-rate FFF beams and using a standard EPID detector has been investigated and some initial limitations highlighted. PMID:26894337

  2. In tandem analysis of CLCN1 and SCN4A greatly enhances mutation detection in families with non-dystrophic myotonia.

    PubMed

    Trip, Jeroen; Drost, Gea; Verbove, Dennis J; van der Kooi, Anneke J; Kuks, Jan B M; Notermans, Nicolette C; Verschuuren, Jan J; de Visser, Marianne; van Engelen, Baziel G M; Faber, Carin G; Ginjaar, Ieke B

    2008-08-01

    Non-dystrophic myotonias (NDMs) are caused by mutations in CLCN1 or SCN4A. The purpose of the present study was to optimize the genetic characterization of NDM in The Netherlands by analysing CLCN1 and SCN4A in tandem. All Dutch consultant neurologists and the Dutch Patient Association for Neuromuscular Diseases (Vereniging Spierziekten Nederland) were requested to refer patients with an initial diagnosis of NDM for clinical assessment and subsequent genetic analysis over a full year. Based on clinical criteria, sequencing of either CLCN1 or SCN4A was performed. When previously described mutations or novel mutations were identified in the first gene under study, the second gene was not sequenced. If no mutations were detected in the first gene, the second gene was subsequently also analysed. Underlying NDM mutations were explored in 54 families. In total, 20% (8 of 40) of our probands with suspected chloride channel myotonia showed no CLCN1 mutations but subsequent SCN4A screening revealed mutations in all of them. All 14 probands in whom SCN4A was primarily sequenced showed a mutation. In total, CLCN1 mutations were identified in 32 families (59%) and SCN4A in 22 (41%), resulting in a diagnostic yield of 100%. The yield of mutation detection was 93% with three recessive and three sporadic cases not yielding a second mutation. Among these mutations, 13 in CLCN1 and 3 in SCN4A were novel. In conclusion, the current results show that in tandem analysis of CLCN1 and SCN4A affords high-level mutation ascertainment in families with NDM.

  3. [Medical activities under adverse conditions. Memisa Medicus Mundi].

    PubMed

    Spanjer, J M

    1992-05-01

    The largest medical missionary organization in the Netherlands is Memisa Medicus Mundi. It has been in operation since 1984 when the organization Memisa, founded in 1925 by 2 doctors from Rotterdam and a priest, merged with Medicus Mundi Nederland. 130 of its doctors work in 80 programs mostly in English-speaking Third World countries. The regional representative for East Africa, worst affected by AIDS, related that a number of doctors work in hospitals where more than 1/2 of patients suffer from AIDS. Many doctors do not want to go to Africa because of the AIDS stigma and the lack of professional challenge of caring mainly for victims of 1 disease. Yet increasingly more foreign doctors are needed, as native doctors are often infected themselves. 1992 World Health Organizations data indicate that 1 out of 40 adult Africans is infected with the human immunodeficiency virus (HIV). In major East African cities the proportion reaches 30% of the adult population. A 1991 visit to Uganda, Tanzania, and Malawi revealed the spectacle of empty villages or inhabited only by children and old people. In Malawi there is 1 doctor for 40,000 people and 1 bed for 600 inhabitants whose average age is 49.3 years for men and 57.2 years for women. The doctors working there stressed prevention, and 1 of them got embroiled in a conflict with the Catholic archbishop because of handing out condoms. Nonetheless, sensitive topics such as sterilization, caesarean section, abortion, euthanasia, and contraception have been addressed to educate the people, since prevention takes precedence over treatment.

  4. Quantifying and Reducing Uncertainties in Estimating OMI Tropospheric Column NO2 Trend over The United States

    NASA Astrophysics Data System (ADS)

    Smeltzer, C. D.; Wang, Y.; Boersma, F.; Celarier, E. A.; Bucsela, E. J.

    2013-12-01

    We investigate the effects of retrieval radiation schemes and parameters on trend analysis using tropospheric nitrogen dioxide (NO2) vertical column density (VCD) measurements over the United States. Ozone Monitoring Instrument (OMI) observations from 2005 through 2012 are used in this analysis. We investigated two radiation schemes, provided by National Aeronautics and Space Administration (NASA TOMRAD) and Koninklijk Nederlands Meteorologisch Instituut (KNMI DAK). In addition, we analyzed trend dependence on radiation parameters, including surface albedo and viewing geometry. The cross-track mean VCD average difference is 10-15% between the two radiation schemes in 2005. As the OMI anomaly developed and progressively worsens, the difference between the two schemes becomes larger. Furthermore, applying surface albedo measurements from the Moderate Resolution Imaging Spectroradiometer (MODIS) leads to increases of estimated NO2 VCD trends over high-emission regions. We find that the uncertainties of OMI-derived NO2 VCD trends can be reduced by up to a factor of 3 by selecting OMI cross-track rows on the basis of their performance over the ocean [see abstract figure]. Comparison of OMI tropospheric VCD trends to those estimated based on the EPA surface NO2 observations indicate using MODIS surface albedo data and a more narrow selection of OMI cross-track rows greatly improves the agreement of estimated trends between satellite and surface data. This figure shows the reduction of uncertainty in OMI NO2 trend by selecting OMI cross-track rows based on the performance over the ocean. With this technique, uncertainties within the seasonal trend may be reduced by a factor of 3 or more (blue) compared with only removing the anomalous rows: considering OMI cross-track rows 4-24 (red).

  5. Effects of High-Intensity Interval Training versus Continuous Training on Physical Fitness, Cardiovascular Function and Quality of Life in Heart Failure Patients

    PubMed Central

    Benda, Nathalie M. M.; Seeger, Joost P. H.; Stevens, Guus G. C. F.; Hijmans-Kersten, Bregina T. P.; van Dijk, Arie P. J.; Bellersen, Louise; Lamfers, Evert J. P.; Hopman, Maria T. E.; Thijssen, Dick H. J.

    2015-01-01

    Introduction Physical fitness is an important prognostic factor in heart failure (HF). To improve fitness, different types of exercise have been explored, with recent focus on high-intensity interval training (HIT). We comprehensively compared effects of HIT versus continuous training (CT) in HF patients NYHA II-III on physical fitness, cardiovascular function and structure, and quality of life, and hypothesize that HIT leads to superior improvements compared to CT. Methods Twenty HF patients (male:female 19:1, 64±8 yrs, ejection fraction 38±6%) were allocated to 12-weeks of HIT (10*1-minute at 90% maximal workload—alternated by 2.5 minutes at 30% maximal workload) or CT (30 minutes at 60–75% of maximal workload). Before and after intervention, we examined physical fitness (incremental cycling test), cardiac function and structure (echocardiography), vascular function and structure (ultrasound) and quality of life (SF-36, Minnesota living with HF questionnaire (MLHFQ)). Results Training improved maximal workload, peak oxygen uptake (VO2peak) related to the predicted VO2peak, oxygen uptake at the anaerobic threshold, and maximal oxygen pulse (all P<0.05), whilst no differences were present between HIT and CT (N.S.). We found no major changes in resting cardiovascular function and structure. SF-36 physical function score improved after training (P<0.05), whilst SF-36 total score and MLHFQ did not change after training (N.S.). Conclusion Training induced significant improvements in parameters of physical fitness, although no evidence for superiority of HIT over CT was demonstrated. No major effect of training was found on cardiovascular structure and function or quality of life in HF patients NYHA II-III. Trial Registration Nederlands Trial Register NTR3671 PMID:26517867

  6. A cluster randomized controlled trial aimed at implementation of local quality improvement collaboratives to improve prescribing and test ordering performance of general practitioners: Study Protocol

    PubMed Central

    Trietsch, Jasper; van der Weijden, Trudy; Verstappen, Wim; Janknegt, Rob; Muijrers, Paul; Winkens, Ron; van Steenkiste, Ben; Grol, Richard; Metsemakers, Job

    2009-01-01

    Background The use of guidelines in general practice is not optimal. Although evidence-based methods to improve guideline adherence are available, variation in physician adherence to general practice guidelines remains relatively high. The objective for this study is to transfer a quality improvement strategy based on audit, feedback, educational materials, and peer group discussion moderated by local opinion leaders to the field. The research questions are: is the multifaceted strategy implemented on a large scale as planned?; what is the effect on general practitioners' (GPs) test ordering and prescribing behaviour?; and what are the costs of implementing the strategy? Methods In order to evaluate the effects, costs and feasibility of this new strategy we plan a multi-centre cluster randomized controlled trial (RCT) with a balanced incomplete block design. Local GP groups in the south of the Netherlands already taking part in pharmacotherapeutic audit meeting groups, will be recruited by regional health officers. Approximately 50 groups of GPs will be randomly allocated to two arms. These GPs will be offered two different balanced sets of clinical topics. Each GP within a group will receive comparative feedback on test ordering and prescribing performance. The feedback will be discussed in the group and working agreements will be created after discussion of the guidelines and barriers to change. The data for the feedback will be collected from existing and newly formed databases, both at baseline and after one year. Discussion We are not aware of published studies on successes and failures of attempts to transfer to the stakeholders in the field a multifaceted strategy aimed at GPs' test ordering and prescribing behaviour. This pragmatic study will focus on compatibility with existing infrastructure, while permitting a certain degree of adaptation to local needs and routines. Trial registration Nederlands Trial Register ISRCTN40008171 PMID:19222840

  7. Splint: the efficacy of orthotic management in rest to prevent equinus in children with cerebral palsy, a randomised controlled trial

    PubMed Central

    2012-01-01

    Background Range of motion deficits of the lower extremity occur in about the half of the children with spastic cerebral palsy (CP). Over time, these impairments can cause joint deformities and deviations in the children's gait pattern, leading to limitations in moblity. Preventing a loss of range of motion is important in order to reduce secondary activity limitations and joint deformities. Sustained muscle stretch, imposed by orthotic management in rest, might be an effective method of preventing a decrease in range of motion. However, no controlled study has been performed. Methods A single blind randomised controlled trial will be performed in 66 children with spastic CP, divided over three groups with each 22 participants. Two groups will be treated for 1 year with orthoses to prevent a decrease in range of motion in the ankle (either with static or dynamic knee-ankle-foot-orthoses) and a third group will be included as a control group and will receive usual care (physical therapy, manual stretching). Measurements will be performed at baseline and at 3, 6, 9 and 12 months after treatment allocation. The primary outcome measure will be ankle dorsiflexion at full knee extension, measured with a custom designed hand held dynamometer. Secondary outcome measures will be i) ankle and knee flexion during gait and ii) gross motor function. Furthermore, to gain more insight in the working mechanism of the orthotic management in rest, morphological parameters like achilles tendon length, muscle belly length, muscle fascicle length, muscle physiological cross sectional area length and fascicle pennation angle will be measured in a subgroup of 18 participants using a 3D imaging technique. Discussion This randomised controlled trial will provide more insight into the efficacy of orthotic management in rest and the working mechanisms behind this treatment. The results of this study could lead to improved treatments. Trial Registration Number Nederlands Trial Register NTR

  8. Cost-effectiveness of problem-solving treatment in comparison with usual care for primary care patients with mental health problems: a randomized trial

    PubMed Central

    2012-01-01

    Background Mental health problems are common and are associated with increased disability and health care costs. Problem-Solving Treatment (PST) delivered to these patients by nurses in primary care might be efficient. The aim of this study was to evaluate the cost-effectiveness of PST by mental health nurses compared with usual care (UC) by the general practitioner for primary care patients with mental health problems. Methods An economic evaluation from a societal perspective was performed alongside a randomized clinical trial. Patients with a positive General Health Questionnaire score (score ≥ 4) and who visited their general practitioner at least three times during the past 6 months were eligible. Outcome measures were improvement on the Hospital Anxiety and Depression Scale and QALYs based on the EQ-5D. Resource use was measured using a validated questionnaire. Missing cost and effect data were imputed using multiple imputation techniques. Bootstrapping was used to analyze costs and cost-effectiveness of PST compared with UC. Results There were no statistically significant differences in clinical outcomes at 9 months. Mean total costs were €4795 in the PST group and €6857 in the UC group. Costs were not statistically significantly different between the two groups (95% CI -4698;359). The cost-effectiveness analysis showed that PST was cost-effective in comparison with UC. Sensitivity analyses confirmed these findings. Conclusions PST delivered by nurses seems cost-effective in comparison with UC. However, these results should be interpreted with caution, since the difference in total costs was mainly caused by 3 outliers with extremely high indirect costs in the UC group. Trial registration Nederlands Trial Register ISRCTN51021015 PMID:23052105

  9. Cyclic volatile methylsiloxanes in human blood as markers for ruptured silicone gel-filled breast implants.

    PubMed

    Rosendahl, Pia; Hippler, Joerg; Schmitz, Oliver J; Hoffmann, Oliver; Rusch, Peter

    2016-05-01

    The replacement of medical-grade silicone with industrial-grade silicone material in some silicone gel-filled breast implants (SBI) manufactured by Poly Implant Prothèse and Rofil Medical Nederland B.V., reported in 2010, which resulted in a higher rupture tendency of these SBI, demonstrates the need for non-invasive, sensitive monitoring and screening methods. Therefore a sensitive method based on large volume injection-gas chromatography coupled to mass spectrometry (LVI-GC/MS) was developed to determine octamethylcyclotetrasiloxane (D4), decamethylcyclopentasiloxane (D5), and dodecamethylcyclo-hexasiloxane (D6) in blood samples from women with intact (n = 13) and ruptured SBI (n = 11). With dichloromethane extraction, sample cooling during preparation, and analysis extraction efficiencies up to 100 % and limits of detection of 0.03-0.05 ng D4-D6/g blood were achieved. Blood samples from women with SBI were investigated. In contrast to women with intact SBI, in blood from women with ruptured SBI higher D4 and D6 concentrations up to 0.57 ng D4/g blood and 0.16 ng D6/g blood were detected. With concentrations above 0.18 D4 ng/blood and 0.10 ng D6/g blood as significant criteria for ruptured SBI, this developed analytical preoperative diagnostic method shows a significant increase of the recognition rate. Finally a higher precision (error rate 17%) than the commonly used clinical diagnostic method, mamma sonography (error rate 46%), was achieved. PMID:26968566

  10. Effects of a Low Dose of Fish Oil on Inflammatory Markers of Brazilian HIV-Infected Adults on Antiretroviral Therapy: A Randomized, Parallel, Placebo-Controlled Trial

    PubMed Central

    Oliveira, Julicristie M.; Rondó, Patrícia H. C.; Lima, Lourdes R. A. V.; Fortuna, Elizabeth S.; Yudkin, John S.

    2015-01-01

    Background: The benefits of antiretroviral therapy for HIV-infected subjects have been limited by an increased risk of metabolic and cardiovascular diseases. The objective of this study was to assess the effects of a low dose of marine omega-3 fatty acids on inflammatory marker concentrations in HIV-infected subjects under antiretroviral therapy (ART). Methods: This was a randomized, parallel, placebo-controlled trial that investigated the effects of 3 g fish oil/day (540 mg of eicosapentaenoic acid—EPA plus 360 mg of docosahexaenoic acid—DHA) or 3 g soy oil/day (placebo) for 24 weeks in 83 male and non-pregnant female HIV-infected adults on ART. Results: There were no differences between groups for the measures at baseline. Multilevel analyses revealed no statistically significant relationship between the longitudinal changes in high sensitivity-C reactive protein (hs-CRP) (Wald Chi2 = 0.17, p = 0.918), fibrinogen (Wald Chi2 = 3.82, p = 0.148), and factor VIII (Wald Chi2 = 5.25, p = 0.073) with fish oil. No significant changes in interleukin-6 (IL6), interleukin-1 beta (IL1-beta) and tumor necrosis factor-alpha (TNF-alpha) serum concentrations were observed with fish oil supplements for 12 weeks. Conclusions: Compared to placebo, a low dose of 900 mg omega-3 fatty acids (EPA plus DHA) in fish oil capsules did not change hs-CRP, fibrinogen, factor VIII, IL6, IL1-beta and TNF-alpha serum concentrations in HIV-infected subjects on ART. Further investigations should consider the assessment of more sensitive inflammatory markers or higher doses to evaluate the effects of marine omega-3 fatty acids in this population. Registered at the Nederlands Trial Register, Identifier no. NTR1798. PMID:26251920

  11. Neurocinematography in Pre-World War II Netherlands: The Magnus-Rademaker Collection.

    PubMed

    Koehler, Peter J; Lameris, Bregt; Hielscher, Eva

    2016-01-01

    Historical films made by neuroscientists have shown up in several countries during past years. Although originally supposed to have been lost, we recently found a collection of films produced between 1909 and 1940 by Rudolf Magnus (1873-1927), professor of pharmacology (Utrecht) and his student Gysbertus Rademaker (1887-1957), professor of physiology (1928, succeeding Willem Einthoven) and neurology (1945, both in Leiden). Both collections deal with the physiology of body posture by the equilibrium of reflex musculature contractions for which experimental studies were done with animals (labyrinthectomies, cerebellectomies, and brainstem sections) and observations on patients. The films demonstrate the results of these studies. Moreover, there are films with babies showing tonic neck reflexes and moving images capturing adults with cerebellar symptoms following cerebellectomies for tumors and several other conditions. Magnus' studies resulted in his well-known Körperstellung (1924, "Body Posture") and Rademaker's research in his Das Stehen (1931, "Standing"). The films probably had an educative and scientific purpose. Magnus demonstrated his films at congresses, including the Eighth International Congress of Physiologists (Vienna, 1910) and Rademaker screened his moving images at meetings of the Amsterdam Neurologists Society (at several occasions as reflected in the Winkler-Monakow correspondence and the Nederlands Tijdschrift voor Geneeskunde). Next to these purposes, the films were used to analyze movement and a series of images from the films were published in articles and books. The films are important historical sources that provide a portrait of the pre-World War II era in neuroscience, partly answering questions on how physicians dealt with patients and researchers with their laboratory animals. Moreover, the films confirm that cinematography was an important scientific tool in neuroscience research.

  12. Ozone columns obtained by ground-based remote sensing in Kiev for Aura Ozone Measuring Instrument validation

    NASA Astrophysics Data System (ADS)

    Shavrina, A. V.; Pavlenko, Y. V.; Veles, A.; Syniavskyi, I.; Kroon, M.

    2007-12-01

    Ground-based observations with a Fourier transform spectrometer in the infrared region (FTIR) were performed in Kiev (Ukraine) during the time frames August-October 2005 and June-October 2006 within the Ozone Monitoring Instrument (OMI) validation project 2907 entitled "OMI validation by ground based remote sensing: ozone columns and profiles" in the frame of the international European Space Agency/Netherlands Agency for Aerospace Programmes/Royal Dutch Meteorological Institute OMI Announcement of Opportunity effort. Ozone column data for 2005 were obtained by modeling the ozone spectral band at 9.6 μm with the radiative transfer code MODTRAN3.5. Our total ozone column values were found to be lower than OMI Differential Optical Absorption Spectroscopy (DOAS) total ozone column data by 8-10 Dobson units (DU, 1 DU = 0.001 atm cm) on average, while our observations have a relatively small standard error of about 2 DU. Improved modeling of the ozone spectral band, now based on HITRAN-2004 spectral data as calculated by us, moves our results toward better agreement with the OMI DOAS total ozone column data. The observations made during 2006 with a modernized FTIR spectrometer and higher signal-to-noise ratio were simulated by the MODTRAN4 model computations. For ozone column estimates the Aqua Atmospheric Infrared Sounder satellite water vapor and temperature profiles were combined with the Aura Microwave Limb Sounder stratospheric ozone profiles and Tropospheric Emission Monitoring Internet Service-Koninklijk Nederlands Meteorologisch Instituut climatological profiles to create a priori input files for spectral modeling. The MODTRAN4 estimates of ozone columns from the 2006 observations compare rather well with the OMI total ozone column data: standard errors are of 1.11 DU and 0.68 DU, standard deviation are of 8.77 DU and 5.37 DU for OMI DOAS and OMI Total Ozone Mapping Spectrometer, respectively.

  13. An Online Health Prevention Intervention for Youth with Addicted or Mentally Ill Parents: Experiences and Perspectives of Participants and Providers from a Randomized Controlled Trial

    PubMed Central

    Bindels, Jill APM; Evers, Silvia MAA; Paulus, Aggie TG; van Asselt, Antoinette DI; van Schayck, Onno CP

    2015-01-01

    providers’ experiences and expectations with the online preventive intervention Kopstoring. It also sheds light on the process of the online provision of Kopstoring and the accompanying RCT. The findings of this study may partly explain dropout rates when delivering online interventions. The change in the (financial) structure of the youth mental health care system in the Netherlands has financial implications for the delivery of prevention programs for youth. Lastly, there are few RCTs that assess the effectiveness and cost-effectiveness of online prevention programs in the field of (youth) mental health care and not many process evaluations of these programs exist. This hampers a good comparison between online interventions and the expectations and experiences of the participants and providers. Trial Registration Nederlands Trial Register: NTR1982; http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=1982 (Archived by WebCite® at http://www.webcitation.org/6d8xYDQbB) PMID:26633244

  14. Study protocol subacromial impingement syndrome: the identification of pathophysiologic mechanisms (SISTIM)

    PubMed Central

    2011-01-01

    controlled acromiohumeral translation assessments); Clinical phenotyping (Constant Score, DASH, WORC, and SF-36 scores). Discussion By relating anatomic properties, kinematics and muscle dynamics to subacromial volume, we expect to identify one or more predominant pathophysiological mechanisms in every SIS patient. These differences in underlying mechanisms are a reflection of the variations in symptoms, clinical scores and outcomes reported in literature. More insight in these mechanisms is necessary in order to optimize future diagnostic and treatment strategies for patients with SIS symptoms. Trial registration Dutch Trial Registry (Nederlands Trial Register) NTR2283. PMID:22168667

  15. Patients with unexplained physical symptoms have poorer quality of life and higher costs than other patient groups: a cross-sectional study on burden

    PubMed Central

    2013-01-01

    registration Nederlands Trial Register, NTR1609 PMID:24344899

  16. Web-based guided self-help for employees with depressive symptoms (Happy@Work): design of a randomized controlled trial

    PubMed Central

    2013-01-01

    with depressive symptoms. This study could stimulate the use of e-mental health interventions in the worksite setting. Trial registration Nederlands Trial Register (NTR): TC2993 PMID:23418886

  17. EMSO: European Multidisciplinary Seafloor Observatory

    NASA Astrophysics Data System (ADS)

    Favali, P.; Partnership, Emso

    2009-04-01

    Tecnologia Marina - Consejo Superior de Investigaciones Cientificas (Spain, ref. Juan Jose Danobeitia); UGOT-Goteborgs Universitet (Sweden, ref. Per Hall); HCMR-Hellenic Centre for Marine Research (Greece, ref. Vasilios Likousis); NOCS-National Oceanography Centre Southampton (United Kingdom, ref. Henry A. Ruhl); UiT-University of Tromsø (Norway, ref. Jürgen Mienert); FCT-Fundação para a Ciência e a Tecnologia (Portugal, ref. Jorge Miguel Alberto de Miranda); ITU-Istanbul Teknik Universitesi (Turkey, ref. Namik Çagatay); NIOZ-Stichting Koninklijk Nederlands Instituut voor Zeeonderzoek (The Netherlands, ref. Tjeerd C.E. van Weering).

  18. The Effectiveness of Lifestyle Triple P in the Netherlands: A Randomized Controlled Trial

    PubMed Central

    Gerards, Sanne M. P. L.; Dagnelie, Pieter C.; Gubbels, Jessica S.; van Buuren, Stef; Hamers, Femke J. M.; Jansen, Maria W. J.; van der Goot, Odilia H. M.; de Vries, Nanne K.; Sanders, Matthew R.; Kremers, Stef P. J.

    2015-01-01

    positive effects on some parent reported child behaviors and parenting measures, no effects were visible on children’s body composition or objectively measured physical activity. Several adjustments of the intervention content are recommended, for example including a booster session. Trial Registration Nederlands Trial Register NTR 2555 PMID:25849523

  19. Effectiveness of Primary Care Triple P on child psychosocial problems in preventive child healthcare: a randomized controlled trial

    PubMed Central

    2013-01-01

    on this admittedly underpowered study, we cannot conclude that PCTP is more effective than UC in preventive child healthcare. Trial registration Nederlands Trial Register (Dutch Trial Register): NTR1338. PMID:24207163

  20. EMSO: European Multidisciplinary Seafloor Observatory

    NASA Astrophysics Data System (ADS)

    Favali, Paolo

    2010-05-01

    Waldmann); IMI-Irish Marine Institute (Ireland, ref. Michael Gillooly); UTM-CSIC-Unidad de Tecnologia Marina - Consejo Superior de Investigaciones Cientificas (Spain, ref. Juan Jose Danobeitia); UGOT-Goteborgs Universitet (Sweden, ref. Per Hall); HCMR-Hellenic Centre for Marine Research (Greece, ref. Vasilios Likousis); NOCS-National Oceanography Centre Southampton (United Kingdom, ref. Henry A. Ruhl); UiT-University of Tromsø (Norway, ref. Jürgen Mienert); FCT-Fundação para a Ciência e a Tecnologia (Portugal, ref. Jorge Miguel Alberto de Miranda); ITU-Istanbul Teknik Universitesi (Turkey, ref. Namik Çagatay); NIOZ-Stichting Koninklijk Nederlands Instituut voor Onderzoek der Zee (The Netherlands, ref. Jens Greinert).

  1. Prevention of depression and anxiety in later life: design of a randomized controlled trial for the clinical and economic evaluation of a life-review intervention

    PubMed Central

    Korte, Jojanneke; Bohlmeijer, Ernst T; Smit, Filip

    2009-01-01

    and in its focus on specific, positive memories. Second, the evaluation is likely to answer questions regarding the acceptability and cost-effectiveness of life-review that have not been addressed thoroughly until now. Positive results of this study will make available a new evidence-based intervention to improve public health among people of 55 years and over. Trial registration Nederlands Trial Register TC = 1860. PMID:19619284

  2. An Internet-Based Physical Activity Intervention to Improve Quality of Life of Inactive Older Adults: A Randomized Controlled Trial

    PubMed Central

    Broekhuizen, Karen; de Gelder, Jelle; Wijsman, Carolien A; Wijsman, Liselotte W; Westendorp, Rudi GJ; Verhagen, Evert; Slagboom, Pieternella E; van Mechelen, Willem; van Heemst, Diana; van der Ouderaa, Frans

    2016-01-01

    -to-vigorous physical activity (MVPA) and increase in quality of life. Conclusions Our study shows that an Internet-based physical activity program was effective in improving quality of life in 60-70-year-olds after 3 months, particularly in participants that reached their individually targeted increase in daily physical activity. Trial Registration Nederlands Trial Register: NTR 3045; http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=3045 (Archived by WebCite at http://www.webcitation.org/6fobg2sjJ) PMID:27122359

  3. Influence of Intensified Supervision by Health Care Inspectorates on Online Patient Ratings of Hospitals: A Multilevel Study of More Than 43,000 Online Ratings

    PubMed Central

    Kleefstra, Sophia Martine; Borghans, Ine; Atsma, Femke; van de Belt, Tom H

    2016-01-01

    Background In the Netherlands, hospitals with quality or safety issues are put under intensified supervision by the Dutch Health Care Inspectorate, which involves frequent announced and unannounced site visits and other measures. Patient rating sites are an upcoming phenomenon in health care. Patient reviews might be influenced by perceived quality including the media coverage of health care providers when the health care inspectorate imposes intensified supervision, but no data are available to show how these are related. Objective The aim of this study was to investigate whether and how being under intensified supervision of the health care inspectorate influences online patient ratings of hospitals. Methods We performed a longitudinal study using data from the patient rating site Zorgkaart Nederland, from January 1, 2010 to December 31, 2015. We compared data of 7 hospitals under intensified supervision with a control group of 28 hospitals. The dataset contained 43,856 ratings. We performed a multilevel logistic regression analysis to account for clustering of ratings within hospitals. Fixed effects in our analysis were hospital type, time, and the period of intensified supervision. Random effect was the hospital. The outcome variable was the dichotomized rating score. Results The period of intensified supervision was associated with a low rating score for the hospitals compared with control group hospitals; both 1 year before intensified supervision (odds ratio, OR, 1.67, 95% CI 1.06-2.63) and 1 year after (OR 1.79, 95% CI 1.14-2.81) the differences are significant. For all periods, the odds on a low rating score for hospitals under intensified supervision are higher than for the control group hospitals, corrected for time. Time is also associated with low rating scores, with decreasing ORs over time since 2010. Conclusions Hospitals that are confronted with intensified supervision by the health care inspectorate have lower ratings on patient rating sites. The

  4. Effectiveness of a Worksite Social & Physical Environment Intervention on Need for Recovery, Physical Activity and Relaxation; Results of a Randomized Controlled Trial

    PubMed Central

    Coffeng, Jennifer K.; Boot, Cécile R. L.; Duijts, Saskia F. A.; Twisk, Jos W. R.; van Mechelen, Willem; Hendriksen, Ingrid J. M.

    2014-01-01

    itself could be improved by increasing the intensity of the intervention (for example weekly GMI-sessions), providing physical activity opportunities and exercise schemes, and by more drastic environment interventions (restructuring entire department floor). Trial Registration Nederlands Trial Register NTR2553 PMID:25542039

  5. Primary prevention of overweight in preschool children, the BeeBOFT study (breastfeeding, breakfast daily, outside playing, few sweet drinks, less TV viewing): design of a cluster randomized controlled trial

    PubMed Central

    2013-01-01

    development of overweight and obesity compared to usual care. Trial registration Nederlands Trial Register NTR1831. PMID:24138805

  6. Using an eHealth Intervention to Stimulate Health Behavior for the Prevention of Cognitive Decline in Dutch Adults: A Study Protocol for the Brain Aging Monitor

    PubMed Central

    2015-01-01

    and theories apply when they are used in a setting where no professional back-end is available. Trial Registration Nederlands Trial Register: NTR4144; http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=4144 (Archived by WebCite at http://www.webcitation.org/6cZzwZSg3) PMID:26554496

  7. Case Finding of Mild Cognitive Impairment and Dementia and Subsequent Care; Results of a Cluster RCT in Primary Care

    PubMed Central

    van den Dungen, Pim; Moll van Charante, Eric P.; van de Ven, Peter M.; van Marwijk, Harm W. J.; van der Horst, Henriëtte E.; van Hout, Hein P. J.

    2016-01-01

    diagnoses. As we cannot exclude a clinically relevant effect, a larger study is warranted to replicate ours. Trial Registration Nederlands Trial Register NTR3389 PMID:27310616

  8. An Economic Evaluation of a Video- and Text-Based Computer-Tailored Intervention for Smoking Cessation: A Cost-Effectiveness and Cost-Utility Analysis of a Randomized Controlled Trial

    PubMed Central

    Stanczyk, Nicola E.; Smit, Eline S.; Schulz, Daniela N.; de Vries, Hein; Bolman, Catherine; Muris, Jean W. M.; Evers, Silvia M. A. A.

    2014-01-01

    required to assess changes in quality of life. Future studies with longer follow-up periods are needed to investigate whether cost-utility results regarding quality of life may change in the long run. Trial Registration Nederlands Trial Register NTR3102 PMID:25310007

  9. Use and Appreciation of a Tailored Self-Management eHealth Intervention for Early Cancer Survivors: Process Evaluation of a Randomized Controlled Trial

    PubMed Central

    Willems, Roy A; Bolman, Catherine A W; Mesters, Ilse; Zambon, Victor; Gijsen, Brigitte CM; Lechner, Lilian

    2016-01-01

    early cancer survivors. Results indicated that the module referral advice might be a meaningful intervention component to guide the users in following a preferred selection of modules. These results indicate that the fully automated Web-based KNW provides personal relevant and valuable information and support for early cancer survivors. Therefore, this intervention can complement usual cancer aftercare and may serve as a first step in a stepped-care approach. Conclusions The KNW in general and more specifically the KNW modules were well used and highly appreciated by early cancer survivors. Indications were found that the module referral advice might be a meaningful intervention component to guide the users in following a preferred selection of modules. These results indicate that the fully automated Web-based KNW provides personal relevant and valuable information and support for early cancer survivors. Therefore, this intervention can complement usual cancer aftercare and may serve as a first step in a stepped-care approach. Trial Registration Nederlands Trial Register: NTR3375; http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=3375 (Archived by WebCite at http://www.webcitation.org/6jo4jO7kb) PMID:27554525

  10. The UK Lung Cancer Screening Trial: a pilot randomised controlled trial of low-dose computed tomography screening for the early detection of lung cancer.

    PubMed Central

    Field, John K; Duffy, Stephen W; Baldwin, David R; Brain, Kate E; Devaraj, Anand; Eisen, Tim; Green, Beverley A; Holemans, John A; Kavanagh, Terry; Kerr, Keith M; Ledson, Martin; Lifford, Kate J; McRonald, Fiona E; Nair, Arjun; Page, Richard D; Parmar, Mahesh Kb; Rintoul, Robert C; Screaton, Nicholas; Wald, Nicholas J; Weller, David; Whynes, David K; Williamson, Paula R; Yadegarfar, Ghasem; Hansell, David M

    2016-01-01

    the control arm. A total of 1994 participants underwent CT scanning: 42 participants (2.1%) were diagnosed with lung cancer; 36 out of 42 (85.7%) of the screen-detected cancers were identified as stage 1 or 2, and 35 (83.3%) underwent surgical resection as their primary treatment. Lung cancer was more common in the lowest socioeconomic group. Short-term adverse psychosocial consequences were observed in participants who were randomised to the intervention arm and in those who had a major lung abnormality detected, but these differences were modest and temporary. Rollout of screening as a service or design of a full trial would need to address issues of outreach. The health-economic analysis suggests that the intervention could be cost-effective but this needs to be confirmed using data on actual lung cancer mortality. CONCLUSIONS The UK Lung Cancer Screening (UKLS) pilot was successfully undertaken with 4055 randomised individuals. The data from the UKLS provide evidence that adds to existing data to suggest that lung cancer screening in the UK could potentially be implemented in the 60-75 years age group, selected via the Liverpool Lung Project risk model version 2 and using CT volumetry-based management protocols. FUTURE WORK The UKLS data will be pooled with the NELSON (Nederlands Leuvens Longkanker Screenings Onderzoek: Dutch-Belgian Randomised Lung Cancer Screening Trial) and other European Union trials in 2017 which will provide European mortality and cost-effectiveness data. For now, there is a clear need for mortality results from other trials and further research to identify optimal methods of implementation and delivery. Strategies for increasing uptake and providing support for underserved groups will be key to implementation. TRIAL REGISTRATION Current Controlled Trials ISRCTN78513845. FUNDING This project was funded by the National Institute for Health Research (NIHR) Health Technology Assessment programme and will be published in full in Health

  11. Prevention of multiple pregnancies in couples with unexplained or mild male subfertility: randomised controlled trial of in vitro fertilisation with single embryo transfer or in vitro fertilisation in modified natural cycle compared with intrauterine insemination with controlled ovarian hyperstimulation

    PubMed Central

    Bensdorp, A J; Tjon-Kon-Fat, R I; Bossuyt, P M M; Koks, C A M; Oosterhuis, G J E; Hoek, A; Hompes, P G A; Broekmans, F J M; Verhoeve, H R; de Bruin, J P; van Golde, R; Repping, S; Cohlen, B J; Lambers, M D A; van Bommel, P F; Slappendel, E; Perquin, D; Smeenk, J M; Pelinck, M J; Gianotten, J; Hoozemans, D A; Maas, J W M; Eijkemans, M J C; van der Veen, F; Mol, B W J

    2015-01-01

    0.91 to 1.34) for in vitro fertilisation with single embryo transfer and 0.91 (0.73 to 1.14) for in vitro fertilisation in a modified natural cycle. These 95% confidence intervals do not extend below the predefined threshold of 0.69 for inferiority. Multiple pregnancy rates per ongoing pregnancy were 6% (7/121) after in vitro fertilisation with single embryo transfer, 5% (5/102) after in vitro fertilisation in a modified natural cycle, and 7% (8/119) after intrauterine insemination with ovarian hyperstimulation (one sided P=0.52 for in vitro fertilisation with single embryo transfer compared with intrauterine insemination with ovarian hyperstimulation; one sided P=0.33 for in vitro fertilisation in a modified natural cycle compared with intrauterine insemination with controlled ovarian hyperstimulation). Conclusions In vitro fertilisation with single embryo transfer and in vitro fertilisation in a modified natural cycle were non-inferior to intrauterine insemination with controlled ovarian hyperstimulation in terms of the birth of a healthy child and showed comparable, low multiple pregnancy rates. Trial registration Current Controlled Trials ISRCTN52843371; Nederlands Trial Register NTR939. PMID:25576320

  12. Changing Behavioral Lifestyle Risk Factors Related to Cognitive Decline in Later Life Using a Self-Motivated eHealth Intervention in Dutch Adults

    PubMed Central

    Qin, Li; Baars, Maria AE; de Lange, Annet; Kessels, Roy PC; Olde Rikkert, Marcel GM

    2016-01-01

    Dutch population, this eHealth intervention resulted in lifestyle changes in behavioral risk factors associated with cognitive decline, and these improvements lasted over the period of 1 year. Given the general aging of our workforce, this eHealth intervention opens new avenues for the widespread use of cost-effective self-motivated prevention programs aimed at prevention of early-stage cognitive decline and more self-management of their risk factors. Trial Registration Nederlands Trial Register: NTR4144; http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=4144 (Archived by WebCite at http://www.webcitation.org/6cZzwZSg3). PMID:27317506

  13. Effect of oestrous synchronization with estradiol 17beta and progesterone on follicular wave dynamics in dairy heifers.

    PubMed

    Garcia, A; Salaheddine, M

    2001-12-01

    An experiment was designed to evaluate the effects of estradiol-17beta (E17beta) on follicular wave dynamics and ovulatory response in Holstein heifers receiving either a progestogen ear-implant (Crestar; Intervet International b.v. Boxmeer, The Netherlands) or an intravaginal progesterone-releasing device [controlled internal drug release-bovine device (Eazibreed, CIDR-B; Bodinco BV, Alkmaar, The Netherlands)]. For comparison, another group of heifers was also synchronized using Crestar plus an injection of estradiol valerate (EV) and norgestomet as recommended by the pharmaceutical company. Twenty 20-22-month-old cycling Holstein heifers were allocated to one of the following treatment groups at random stages of the oestrous cycle: (I) simultaneous insertion of Crestar and intramuscular injection of 3 mg norgestomet and 5 mg EV (Crestar 9 + EV 9); (II) simultaneous insertion of Crestar and intramuscular injection of 5 mg E17beta (Crestar 9 + E17beta 9); (III) insertion of Crestar followed 2 days later by intramuscular injection of 5 mg E17beta (Crestar 9 + E17beta 7); or (IV) insertion of CIDR-B device followed 2 days later by intramuscular injection of 5 mg E17beta (CIDR 9 + E17beta 7). The CIDR-B or Crestar implants were removed after 9 days and all heifers received 500 microg Cloprostenol (Estrumate, Pitman-Moore Nederland BV, Houten. The Netherlands). Ovarian ultrasonographic examinations were performed once daily during the synchronization period using a B-mode scanner equipped with a 7.5 MHz linear-array transrectal transducer. In addition, heifers were scanned every 12 h after implant/device withdrawal until 3 days after ovulation in order to monitor follicular activity, detect ovulation and subsequent early luteal formation. Detection of oestrus was performed every 6 h for 4 days after device/implant removal. Oestrus was observed 24-32 h before ovulation in all heifers. The mean hours interval from treatment withdrawal to ovulation was not significantly

  14. The Influence of User Characteristics and a Periodic Email Prompt on Exposure to an Internet-Delivered Computer-Tailored Lifestyle Program

    PubMed Central

    van Osch, Liesbeth; Schulz, Daniela N; Kremers, Stef PJ; de Vries, Hein

    2012-01-01

    interval 10.65–78.52; P < .001). Conclusions Older, male, and employed participants, and those with a lower income, higher body mass index, and a relatively unhealthy lifestyle were more likely to initiate a CT module. Module completers predominantly had a higher income and age. The current program therefore succeeded in reaching those people who benefit most from online lifestyle interventions. However, these people tended to disengage from the program. This underlines the importance of additional research into program adjustments and strategies that can be used to stimulate prolonged program use. Furthermore, sending periodic email prompts significantly increased revisits to the program. Though promising, this effect was modest and needs to be further examined, in order to maximize the potential of periodic email prompting. Trial Registration Nederlands Trial Register (NTR: 1786) and Medical Ethics Committee of Maastricht University and the University Hospital Maastricht (NL2723506809/MEC0903016); http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=1786 (Archived by WebCite at http://www.webcitation.org/65hBXA6V7) PMID:22382037

  15. A Web-Based Computer-Tailored Alcohol Prevention Program for Adolescents: Cost-Effectiveness and Intersectoral Costs and Benefits

    PubMed Central

    2016-01-01

    intervention was more costly and more effective in comparison with CAU. ICERs differed for both perspectives, namely €40 and €79 from the health care perspective to €62 and €144 for the societal perspective per incremental reduction of one glass of alcohol per week and one binge drinking occasion per 30 days, respectively. Subgroup analyses showed, from both perspectives and for both outcome measures, that the intervention was cost-effective for older adolescents (aged 17-19 years) and those at a lower educational level and, from a health care perspective, the male and nonreligious adolescent subgroups. Conclusions Computer-tailored feedback could be a cost-effective way to target alcohol use and binge drinking among adolescents. Including ICBs in the economic evaluation had an impact on the cost-effectiveness results of the analysis. It could be worthwhile to aim the intervention specifically at specific subgroups. Trial Registration Nederlands Trial Register: NTR4048; http://www.trialregister.nl/trialreg/admin/rctview.asp?TC=4048 (Archived by Webcite at http://www.webcitation.org/6c7omN8wG) PMID:27103154

  16. Interpretation of heavy rainfall spatial distribution in mountain watersheds by copula functions

    NASA Astrophysics Data System (ADS)

    Grossi, Giovanna; Balistrocchi, Matteo

    2016-04-01

    hydro-meteorological network, consisting of about 30 rain gauges and 10 hydrometers, monitors this medium-size watershed. A decade of rainfall-runoff event observations are available. Severe rainfall events were identified with reference to a main raingauge station, by using an interevent time definition and a depth threshold. Rainfall depths were thus derived and the spatial variability of their association degree was represented by using the Kendall coefficient. A unique copula model based on Gumbel copula function was finally found to be suitable to represent the dependence structure relating to rainfall depths observed in distinct raingauges. Bardossy A., Pegram G. (2009), Copula based multisite model for daily precipitation simulation, Hydrol. Earth Syst. Sci., 13, 2299-2314. Genest C., Rémilland B., Beaudoin D. (2009), Goodness-of-fit tests for copulas: a review and a power study, Insur. Math. Econ., 44(2), 199-213. Joe H. (1997), Multivariate models and dependence concepts, Chapman and Hall, London. Nelsen R. B. (2006), An introduction to copulas, second ed., Springer, New York. Salvadori G., De Michele C., Kottegoda N. T., Rosso R. (2007), Extremes in nature: an approach using copulas, Springer, Dordrecht, The Nederlands.

  17. [Veterinarians:'Watch your affairs!'].

    PubMed

    Vos, J H; Deleu, S A; Heling, W; de Vries, A R; Zeeuwen, A A

    2000-09-15

    The most relevant results of a written questionnaire among veterinarians in the Netherlands are presented and discussed. The inquiry was performed by MarketResponse Nederland BV. The objective was to get an overview of the current perception and the future view of the profession. The response was 37%. Most respondents (66%) were practitioners, 7% were active in research or teaching institutions, 5% were governmental employees, 5% were employed in industry, and 17% did not belong to any of these categories (retired, unemployed etc.). Forty-seven per cent of the veterinarians practised mainly small animal medicine, 24% large animal medicine (cattle 15%, swine 8%, and poultry 1%), and 4% equine medicine; 24% worked in mixed practices. This division reflects the real-life situation. The percentage of female respondents was considerably higher in the group of recent graduates than in the other groups of graduates (increasing from 27% in the graduation period 1980-1989 to 56% in the period 1990-1999). Sixty per cent of the veterinarians worked more than 40 hours a week. Veterinarians considered themselves reliable, honest, professional, client-minded, and animal-friendly. According to them, the public perceived veterinarians as being animal-friendly, professional, and reliable. Veterinarians were less satisfied in their current position than other professional groups, particularly with regard to their income. Their current market position was considered indifferent or good. This position was influenced negatively by the decrease in the number of animals and competition from non-veterinarians and others. The situation could be improved by collaboration and practice fusions, specialization, and differentiation. More demanding and price-conscious clients and governmental regulations were considered important trends. Social, management, and marketing skills, increased knowledge and cooperation, and a vision of future developments were considered essential in order to be able

  18. The Glanerbrug Breccia: Evidence for a Separate L/LL-Chondritic Parent Body?

    NASA Astrophysics Data System (ADS)

    Welten, K. C.; Lindner, L.; Poorter, R. P. E.; Kallemeyn, G. W.; Rubin, A. E.; Wasson, J. T.

    1992-07-01

    . Wasson and coworkers for their hospitality at UCLA. This work was financially supported by the "Nederlands Organisatie voor Wetenschappelijk Onderzoek" (NWO). References. 1. Lindner L. et al. (1990) Meteoritics 25, 379 (abs.); 2. Bunch T.E. and Rajan R.S. (1988) in Meteorites and the Early Solar System (eds. J.F. Kerridge and M.S. Matthews), pp. 144-164, Univ. Arizona Press, Tucson, Arizona; 3. Kallemeyn, G.W. et al. (1989) GCA 53, 2747-2767; 4. Rubin A.E. (1990) GCA 54, 1217-1232; 5. Schultz L. (pers. comm.); 6. Wasson J.T. and Wang S. (1991), Meteoritics 26, 161-167.

  19. Hydrogeological properties of bank storage area in Changwon city, Korea

    NASA Astrophysics Data System (ADS)

    Hamm, S.-Y.; Kim, H.-S.; Cheong, J.-Y.; Ryu, S. M.; Kim, M. J.

    2003-04-01

    Bank filtrated water has been used in developed countries such as United States, France, Germany, Austria, Nederland and so on. In Korea, most of the drinking water is provided from the surface water. However, drinking water acquisition is becoming difficult due to the degradation of surface water quality. In special, the quality of drinking water source is much lower in downstream area than in upstream area. Thus, the use of bank filtrated water is getting attracted by central and local governments in Korea. The bank filtrated water was surveyed in the areas of Yeongsan river, Nakdong river, Geum river and Han river. Up to present, however, the downstream areas of Nakdong river are most suitable places to apply the bank filtration system. This study investigates hydrogeological characteristics of bank-storage area located in Daesan- Myeon, Changwon city, adjacent the downstream of Nakdong river. Changwon city is the capital city of Gyeongsangnam-Do province. Changwon city uses water derived from Nakdong river as municipal water. However, the quantity and quality of the river water are gradually decreased. Thus, Changwon city developed two sites of bank filtration system in Daesan-myeon and Buk-myeon. Pumping rate is 2,000m3/day at present and will be increased to 60,000m3/day in Daesan-myeon site at the end of the first stage of the project. For the study, we conducted pumping tests four times on seven pumping wells (PW1, PW2, PW3, PW4, PW5, PW6, and PW7) and twelve drill holes (BH-2, OW2-OW12) in the area of 370 m x 100 m. Pumping wells PW1 and PW2 were drilled in 1999 by Samjung Engineering Co. and pumping wells PW3, PW4, PW5, PW6 and PW7 were drilled in 2000 by Donga Construction Co. and Daeduk Gongyeong Co. The pumping wells are located at 45-110 meters from Nakdong riverside. The geology of the study area is composed of volcanic rocks (Palryeongsan tuff and Jusasan andesitic rock) and alluvium. Palryeongsan tuff consists of mostly green tuff with partly

  20. A Vertical Differential Configuration in GPR prospecting

    NASA Astrophysics Data System (ADS)

    Persico, Raffaele; Pochanin, Gennadiy; Varianytsia-Roshchupkina, Liudmyla; Catapano, Ilaria; Gennarelli, Gianluca; Soldovieri, Francesco

    2015-04-01

    and receiving modules of antenna", Patent 81652 Ukraine: IPC (2006) H01Q 9/00 H01Q 19/10 / publ. 25.01.08, Bull. N. 2 [6] G.P. Pochanin, "Some Advances in UWB GPR," in "Unexploded Ordnance Detection and Mitigation, - NATO Science for Peace and Security Series -B: Physics and Biophysics - Ed. by Jim Byrnes, Springer: Dordrecht, (The Nederland), 2009. pp.223-233. [7] R. Persico, F. Soldovieri, R. Pierri, "Convergence Properties of a Quadratic Approach to the Inverse Scattering Problem", Journal of Optical Society of America Part A, vol. 19, n. 12, pp. 2424-2428, December 2002. [8] R. Pierri, G. Leone, F. Soldovieri, R. Persico, "Electromagnetic inversion for subsurface applications under the distorted Born approximation" Nuovo Cimento, vol. 24C, N. 2, pp 245-261, March-April 2001. [9] R. Persico, Introduction to ground penetrating Radar: Inverse Scattering and data Processing, in print on Wiley and Sons, 2014, ISBN 9781118305003.

  1. ATES Smart Grids research project overview and first results

    NASA Astrophysics Data System (ADS)

    Bloemendal, Martin; Jaxa-Rozen, Marc; Rostampour, Vahab

    2016-04-01

    ) after which we then incorporate the entire city of Amsterdam (3). The first results of the academic model are promising (Jaxa-Rozen et al., 2015), it shows that stable situations result even for ATES system that are placed a lot closer together than what current regulations would dictate. This has a positive effect on the total GHG emission reduction, but a negative effect on individual efficiency. In the presentation at EGU we will show results from the academic case, discuss several challenges for the optimization and present details on the analytical geohydrological ATES well model required for the controller to keep track of energy losses in its own wells. References • Bakr, M., van Oostrom, N., Sommer, W., 2013. Efficiency of and interference among multiple Aquifer Thermal Energy Storage systems; A Dutch case study. Renewable Energy 60, 53-62. • Bloemendal, M., Olsthoorn, T., Boons, F., 2014. How to achieve optimal and sustainable use of the subsurface for Aquifer Thermal Energy Storage. Energy Policy 66, 104-114. • Bloemendal, M., Olsthoorn, T., van de Ven, F., 2015. Combining climatic and geo-hydrological preconditions as a method to determine world potential for aquifer thermal energy storage. Science of the Total Environment 538 621-633. • CBS, 2015. Hernieuwbare energie in Nederland 2014 (renewable energy in NL). Central authority for statistics in NL, Den Haag. • EU, 2010. Directive on the energy performance of buildings, in: Union, O.J.o.t.E. (Ed.), 153;13-35. EU-Parliament, European Union, Strasbourg. • EU, 2014. A review of factors affecting environmental and economic life-cycle performance for electrically-driven heat pumps, in: Commission, E. (Ed.). • Heekeren, V.v., Bakema, G., 2015. The Netherlands Country Update on Geothermal Energy, World Geothermal Congress, Melbourne. • Jaxa-Rozen, M., Kwakkel, J.H., Bloemendal, M., 2015. The Adoption and Diffusion of Common-Pool Resource-Dependent Technologies: The Case of Aquifer Thermal Energy