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Sample records for neodymium 146 target

  1. 146 Kepler-Lamost targets fundamental parameters

    NASA Astrophysics Data System (ADS)

    Wu, Yaqian

    2015-08-01

    Accurate stellar fundamental parameters with high precision are important for distinguishing stellar populationand star study.Turn-off stars are in the relatively vital stellar evolution state. Studying turn-off stars can help us to have a more comprehensive understand of the stellar physics.With the help of observation provided by Lamost project, we obtain atmospheric parameters of 146 turn-off stars from LSP3 pipeline. Combined with stellar pulsation data from Kepler, we can get asteroseismic characteristic of stars,such as Δν and νmax.In this paper,we constructed a grid of evolutionary models, with the mass range from 0.8 to 2.5 M⊙ and metallicities Zini = 0.0085, 0.0105, 0.0130, 0.0165, 0.0200, 0.0250, 0.0300, 0.0400 (i.e.[Fe/H] from -0.3 to 0.4dex).All evolutionary tracks were started in the pre-main sequence birth line and ended at the base of Red Giant Branch.Based on the stellar model grid we constructed,as well as Kepler-Lamost observations, we obtained fundamental parameters of 146 around turn-off stars, and found that 112 targets lied in turn-off state or in the Main Sequence,15 targets are subgiant stars and 7 targets have evolved to the red giants stage.Then we use pulsation code(JIG) of Guenther to extract theorical individual frequencies and calculate theorical Δν.Meanwhile we obtained more precise fundamental parameters of these stars.

  2. MicroRNA 329 Suppresses Angiogenesis by Targeting CD146

    PubMed Central

    Wang, Ping; Luo, Yongting; Duan, Hongxia; Xing, Shu; Zhang, Jianlin; Lu, Di; Feng, Jing; Yang, Dongling; Song, Lina

    2013-01-01

    CD146, an endothelial biomarker, has been shown to be aberrantly upregulated during pathological angiogenesis and functions as a coreceptor for vascular endothelial growth factor receptor 2 (VEGFR-2) to promote disease progression. However, the regulatory mechanisms of CD146 expression during angiogenesis remain unclear. Using a microRNA screening approach, we identified a novel negative regulator of angiogenesis, microRNA 329 (miR-329), that directly targeted CD146 and inhibited CD146-mediated angiogenesis in vitro and in vivo. Endogenous miR-329 expression was downregulated by VEGF and tumor necrosis factor alpha (TNF-α), resulting in the elevation of CD146 in endothelial cells. Upregulation of CD146 facilitated an endothelial response to VEGF-induced SRC kinase family (SKF)/p38 mitogen-activated protein kinase (MAPK)/NF-κB activation and consequently promoted endothelial cell migration and tube formation. Our animal experiments showed that treatment with miR-329 repressed excessive CD146 expression on blood vessels and significantly attenuated neovascularization in a mouse model of pathological angiogenesis. Our findings provide the first evidence that CD146 expression in angiogenesis is regulated by miR-329 and suggest that miR-329 could present a potential therapeutic tool for the treatment of angiogenic diseases. PMID:23878390

  3. Targeting soluble CD146 with a neutralizing antibody inhibits vascularization, growth and survival of CD146-positive tumors.

    PubMed

    Stalin, J; Nollet, M; Garigue, P; Fernandez, S; Vivancos, L; Essaadi, A; Muller, A; Bachelier, R; Foucault-Bertaud, A; Fugazza, L; Leroyer, A S; Bardin, N; Guillet, B; Dignat-George, F; Blot-Chabaud, M

    2016-10-20

    CD146 (MUC-18, MCAM) expression on cancer cells correlates with cancer progression and a bad prognosis in several tumors, including melanoma and pancreatic tumors. Deciphering the mechanism mediating the CD146 role in cancer is essential for generating new therapeutic strategies. We found that CD146 expression in cancer cells is associated with a secretion of soluble CD146 (sCD146) that constitutes an active player in tumor development. Indeed, sCD146 induces the overexpression of its binding protein, angiomotin, on both endothelial and cancer cells and promotes both paracrine effects on angiogenesis and autocrine effects on cancer cells proliferation and survival. These last effects are mediated in part through the induction and phosphorylation of c-myc in cancer cells. In mice models xenografted with human CD146-positive melanoma or pancreatic cancer cells, administration of a novel monoclonal antibody specifically targeting sCD146, but not its membrane form, successfully suppresses tumor vascularization and growth. Our findings demonstrate that sCD146 secreted by CD146-positive tumors mediates important pro-angiogenic and pro-tumoral effects. Targeting sCD146 with a novel neutralizing antibody could thus constitute an innovative therapeutic strategy for the treatment of CD146-positive tumors.

  4. Evaluation of CD146 as Target for Radioimmunotherapy against Osteosarcoma

    PubMed Central

    Bønsdorff, Tina B.; Abbas, Nasir; Bruland, Øyvind S.; Jonasdottir, Thora J.; Mælandsmo, Gunhild M.; Larsen, Roy H.

    2016-01-01

    Background Osteosarcoma is a rare form of cancer but with a substantial need for new active drugs. There is a particular need for targeted therapies to combat metastatic disease. One possible approach is to use an antibody drug conjugate or an antibody radionuclide conjugate to target the osteosarcoma metastases and circulating tumor cells. Herein we have evaluated a radiolabeled monoclonal antibody targeting CD146 both in vitro and in vivo. Methods and Results A murine monoclonal anti-CD146 IgG1 isotype antibody, named OI-3, was developed along with recombinant chimeric versions with human IgG1 or human IgG3 Fc sequences. Using flow cytometry, selective binding of OI-3 to human osteosarcoma cell lines OHS, KPDX and Saos-2 was confirmed. The results confirm a higher expression level of CD146 on human osteosarcoma cells than HER2 and EGFR; antigens targeted by commercially available therapeutic antibodies. The biodistribution of 125I-labeled OI-3 antibody variants was compared with 125I-labeled chimeric anti-EGFR antibody cetuximab in nude mice with subcutaneous OHS osteosarcoma xenografts. OI-3 was able to target CD146 expressing tumors in vivo and showed improved tumor to tissue targeting ratios compared with cetuximab. Subsequently, the three OI-3 variants were conjugated with p-SCN-Bn-DOTA and labeled with a more therapeutically relevant radionuclide, 177Lu, and their biodistributions were studied in the nude mouse model. The 177Lu-labeled OI-3 variants were stable and had therapeutically relevant biodistribution profiles. Dosimetry estimates showed higher absorbed radiation dose to tumor than all other tissues after administration of the chimeric IgG1 OI-3 variant. Conclusion Our results indicate that CD146 can be targeted in vivo by the radiolabeled OI-3 antibodies. PMID:27776176

  5. MicroRNA-146b promotes myogenic differentiation and modulates multiple gene targets in muscle cells.

    PubMed

    Khanna, Nidhi; Ge, Yejing; Chen, Jie

    2014-01-01

    MicroRNAs are established as crucial modulators of skeletal myogenesis, but our knowledge about their identity and targets remains limited. In this study, we have identified microRNA-146b (miR-146b) as a novel regulator of skeletal myoblast differentiation. Following up on a previous microRNA profiling study, we establish that the expression of miR-146b is up-regulated during myoblast differentiation in vitro and muscle regeneration in vivo. Inhibition of miR-146b led to reduced myoblast differentiation, whereas overexpression of miR-146b enhanced differentiation. Computational prediction combined with gene expression information has revealed candidates for miR-146b targets in muscles. Among them, the expression of Smad4, Notch1, and Hmga2 are significantly suppressed by miR-146b overexpression in myocytes. In addition, expression levels of Smad4, Notch1 and Hmga2 are decreased during myoblast differentiation and muscle regeneration, inversely correlating to the levels of miR-146b. Importantly, inhibition of endogenous miR-146b prevents the down-regulation of Smad4, Notch1 and Hmga2 during differentiation. Furthermore, miR-146b directly targets the microRNA response elements (MREs) in the 3'UTR of those genes as assessed by reporter assays. Reporters with the seed regions of MREs mutated are insensitive to miR-146b, further confirming the specificity of targeting. In conclusion, miR-146b is a positive regulator of myogenic differentiation, possibly acting through multiple targets.

  6. Neodymium Magnets.

    ERIC Educational Resources Information Center

    Wida, Sam

    1992-01-01

    Uses extremely strong neodymium magnets to demonstrate several principles of physics including electromagnetic induction, Lenz's Law, domain theory, demagnetization, the Curie point, and magnetic flux lines. (MDH)

  7. Neodymium Magnets.

    ERIC Educational Resources Information Center

    Wida, Sam

    1992-01-01

    Uses extremely strong neodymium magnets to demonstrate several principles of physics including electromagnetic induction, Lenz's Law, domain theory, demagnetization, the Curie point, and magnetic flux lines. (MDH)

  8. miR146a-mediated targeting of FANCM during inflammation compromises genome integrity

    PubMed Central

    Kim, Hyun Hee; Lee, Hyun-Seo; Jun, Semo; Cha, Jeong-Heon; Kee, Younghoon; You, Ho Jin; Lee, Jung-Hee

    2016-01-01

    Inflammation is a potent inducer of tumorigenesis. Increased DNA damage or loss of genome integrity is thought to be one of the mechanisms linking inflammation and cancer development. It has been suggested that NF-κB-induced microRNA-146 (miR146a) may be a mediator of the inflammatory response. Based on our initial observation that miR146a overexpression strongly increases DNA damage, we investigated its potential role as a modulator of DNA repair. Here, we demonstrate that FANCM, a component in the Fanconi Anemia pathway, is a novel target of miR146a. miR146a suppressed FANCM expression by directly binding to the 3′ untranslated region of the gene. miR146a-induced downregulation of FANCM was associated with inhibition of FANCD2 monoubiquitination, reduced DNA homologous recombination repair and checkpoint response, failed recovery from replication stress, and increased cellular sensitivity to cisplatin. These phenotypes were recapitulated when miR146a expression was induced by overexpressing the NF-κB subunit p65/RelA or Helicobacter pylori infection in a human gastric cell line; the phenotypes were effectively reversed with an anti-miR146a antagomir. These results suggest that undesired inflammation events caused by a pathogen or over-induction of miR146a can impair genome integrity via suppression of FANCM. PMID:27351285

  9. Near-Infrared Neodymium Tag for Quantifying Targeted Biomarker and Counting Its Host Circulating Tumor Cells.

    PubMed

    Liu, Chunlan; Lu, Shu; Yang, Limin; Chen, Peijie; Bai, Peiming; Wang, Qiuquan

    2017-09-05

    Quantitative information on a targeted analyte in a complex biological system is the most basic premise for understanding its involved mechanisms, and thus precise diagnosis of a disease if it is a so-called biomarker. Here, we designed and synthesized a neodymium (Nd)-cored tag [1,4,7,10-tetraazacyclododecane-1,4,7-trisacetic acid (DOTA)-Nd complex together with a light-harvesting antenna aminofluorescein (AMF, λex/em = 494/520 nm), AMF-DOTA-Nd] with duplex signals, second near-infrared (NIR) window luminescence (λem = 1065 nm, 2.5 μs), and stable isotopic mass ((142)Nd). AMF-DOTA-Nd covalently linked with a urea-based peptidomimetic targeting group, 2-[3-(1,3-dicarboxypropyl)-ureido]pentanedioic acid (DUPA)-8-Aoc-Phe-Phe-Cys (DUPAaFFC) (DUPAaFFC-AMF-DOTA-Nd), allowing us to detect and quantify prostate-specific membrane antigen (PSMA) and its splice variants (total PSMA, tPSMA), which was set as an example of targeted biomarkers in this study, using NIR and inductively coupled plasma mass spectrometry (ICPMS) with the limit of detection (LOD) (3σ) of 0.3 ng/mL. When it was applied to the analysis of 80 blood samples from prostate cancer (PCa) and benign prostatic hyperplasia (BPH) patients as well as healthy volunteers, we found that 320 and 600 ng/mL tPSMA could be recommended as the threshold values to differentiate BPH from PCa and for the diagnosis of PCa. Moreover, PSMA-positive circulating tumor cells (CTCs) were counted using ICPMS being from 134 to 773 CTCs in the PCa blood samples of the Gleason score from 6 to 9 when the cell membrane-spanning mPSMA was tagged. Such a methodology developed could be expected to be applicable to other clinic-meaningful biomolecules and their host CTCs in liquid biopsy, when other specific targeting groups are modified to the NIR Nd tag.

  10. MicroRNA-146a targets PRKCE to modulate papillary thyroid tumor development.

    PubMed

    Zhang, Xiaoping; Li, Dan; Li, Maoquan; Ye, Meng; Ding, Lanbao; Cai, Haidong; Fu, Da; Lv, Zhongwei

    2014-01-15

    MicroRNAs are single-stranded noncoding RNAs composed of approximately 22 nucleotides that suppress gene expression by selectively binding via base-pairing to the complementary 3'-untranslated region (3'-UTR) of messenger RNA transcripts. Protein kinase C epsilon (PKCε) is an important modulating member of the transducing Ras/Raf-1 signal pathway; a computational search revealed miR-146a putatively binds to the 3'-UTR of the PRKCE gene, and thus decreasing PKCε expression. Moreover, PKCε inhibits mitochondrial apoptosis and is associated with the Bcl family. However, it has been previously reported that miR-146a expression in papillary thyroid carcinoma (PTC) is slightly elevated. Thus, we hypothesized that because miR-146a expression depends on nuclear factor kappaB (NF-κB) activation and NF-κB expression is elevated in PTC, miR-146a is potentially upregulated in PTC via negative feedback of NF-κB, and thus suppressing PKCε expression. In our study, we investigated whether overexpression of miR-146a, a tumor-suppressing-miR, in PTC cells decreases cell survival and induces apoptosis. Luciferase reporter assay analysis confirmed the direct binding of miR-146a and PRKCE 3'-UTR. Specific overexpression of exogenous miR-146a significantly decreased PKCε levels in PTC cell line NPA-187 and increased apoptosis. Additionally, using stably expressing miR-146a thyroid carcinoma cells to establish subcutaneous tumors, the tumor growth exhibited significant inhibition. Our study confirmed the tumor-suppressing role of miR-146a in thyroid carcinoma cells and contributes to the knowledge regarding modulation of Ras/Raf-1 signal transduction and apoptosis via PKCε targeted by miR-146a in PTC; moreover, our findings confirmed that miR-146a is involved in the feedback system of the classical NF-κB signal pathway in PTC.

  11. MicroRNA-146a is a therapeutic target and biomarker for peripartum cardiomyopathy.

    PubMed

    Halkein, Julie; Tabruyn, Sebastien P; Ricke-Hoch, Melanie; Haghikia, Arash; Nguyen, Ngoc-Quynh-Nhu; Scherr, Michaela; Castermans, Karolien; Malvaux, Ludovic; Lambert, Vincent; Thiry, Marc; Sliwa, Karen; Noel, Agnes; Martial, Joseph A; Hilfiker-Kleiner, Denise; Struman, Ingrid

    2013-05-01

    Peripartum cardiomyopathy (PPCM) is a life-threatening pregnancy-associated cardiomyopathy in previously healthy women. Although PPCM is driven in part by the 16-kDa N-terminal prolactin fragment (16K PRL), the underlying molecular mechanisms are poorly understood. We found that 16K PRL induced microRNA-146a (miR-146a) expression in ECs, which attenuated angiogenesis through downregulation of NRAS. 16K PRL stimulated the release of miR-146a-loaded exosomes from ECs. The exosomes were absorbed by cardiomyocytes, increasing miR-146a levels, which resulted in a subsequent decrease in metabolic activity and decreased expression of Erbb4, Notch1, and Irak1. Mice with cardiomyocyte-restricted Stat3 knockout (CKO mice) exhibited a PPCM-like phenotype and displayed increased cardiac miR-146a expression with coincident downregulation of Erbb4, Nras, Notch1, and Irak1. Blocking miR-146a with locked nucleic acids or antago-miRs attenuated PPCM in CKO mice without interrupting full-length prolactin signaling, as indicated by normal nursing activities. Finally, miR-146a was elevated in the plasma and hearts of PPCM patients, but not in patients with dilated cardiomyopathy. These results demonstrate that miR-146a is a downstream-mediator of 16K PRL that could potentially serve as a biomarker and therapeutic target for PPCM.

  12. MicroRNA-146a is a therapeutic target and biomarker for peripartum cardiomyopathy

    PubMed Central

    Halkein, Julie; Tabruyn, Sebastien P.; Ricke-Hoch, Melanie; Haghikia, Arash; Nguyen, Ngoc-Quynh-Nhu; Scherr, Michaela; Castermans, Karolien; Malvaux, Ludovic; Lambert, Vincent; Thiry, Marc; Sliwa, Karen; Noel, Agnes; Martial, Joseph A.; Hilfiker-Kleiner, Denise; Struman, Ingrid

    2013-01-01

    Peripartum cardiomyopathy (PPCM) is a life-threatening pregnancy-associated cardiomyopathy in previously healthy women. Although PPCM is driven in part by the 16-kDa N-terminal prolactin fragment (16K PRL), the underlying molecular mechanisms are poorly understood. We found that 16K PRL induced microRNA-146a (miR-146a) expression in ECs, which attenuated angiogenesis through downregulation of NRAS. 16K PRL stimulated the release of miR-146a–loaded exosomes from ECs. The exosomes were absorbed by cardiomyocytes, increasing miR-146a levels, which resulted in a subsequent decrease in metabolic activity and decreased expression of Erbb4, Notch1, and Irak1. Mice with cardiomyocyte-restricted Stat3 knockout (CKO mice) exhibited a PPCM-like phenotype and displayed increased cardiac miR-146a expression with coincident downregulation of Erbb4, Nras, Notch1, and Irak1. Blocking miR-146a with locked nucleic acids or antago-miRs attenuated PPCM in CKO mice without interrupting full-length prolactin signaling, as indicated by normal nursing activities. Finally, miR-146a was elevated in the plasma and hearts of PPCM patients, but not in patients with dilated cardiomyopathy. These results demonstrate that miR-146a is a downstream-mediator of 16K PRL that could potentially serve as a biomarker and therapeutic target for PPCM. PMID:23619365

  13. Samarium-neodymium chronology and rubidium-strontium systematics of an Allende calcium-aluminum-rich inclusion with implications for 146Sm half-life

    NASA Astrophysics Data System (ADS)

    Marks, N. E.; Borg, L. E.; Hutcheon, I. D.; Jacobsen, B.; Clayton, R. N.

    2014-11-01

    Calcium-aluminum-rich inclusions (CAIs) are primitive objects that formed within the protoplanetary disk surrounding the young Sun. Recent Pb-Pb chronologic studies have demonstrated that CAIs are the oldest solar system solids, crystallizing 4567 Ma ago (Amelin et al., 2002; Connelly et al., 2012). The isotope systematics of CAIs therefore provide critical insight into the earliest history of the Solar System. Although Sm-Nd and Rb-Sr geochronometers are highly effective tools for investigating cosmochemical evolution in the early Solar System, previous studies of CAIs have revealed evidence for isotopically disturbed systems. Here we report new age data for Allende CAI Al3S4 derived from both the long-lived (147Sm-143Nd) and short-lived (146Sm-142Nd) isotopic systems. The 147Sm-143Nd chronometer yields an age of 4560±34 Ma that is concordant with 207Pb-206Pb ages for CAIs and indicates that the Sm-Nd system was not significantly disturbed by secondary alteration or nucleosynthetic processes. The slope of the 146Sm-142Nd isochron defines the Solar System initial 146Sm/144Sm of 0.00828±0.00044. This value is significantly different from the value of 0.0094 determined by Kinoshita et al. (2012). Ages recalculated from all published 146Sm-142Nd isochron data using the traditional 103 Ma half-life and the initial 146Sm/144Sm value determined here closely match Pb-Pb and 147Sm-143Nd ages determined on the same samples. In contrast, ages recalculated using the 68 Ma half-life determined by Kinoshita et al. (2012) and either of the initial 146Sm/144Sm values are often anomalously old. This is particularly true for the youngest samples with 146Sm-142Nd isochron ages that are most sensitive to the choice of 146Sm half-life used in the age calculation. In contrast to the Sm-Nd isotope system, the Rb-Sr system is affected by alteration but yields an apparent isochron with a slope corresponding to a much younger age of 4247±110 Ma. Although the Rb-Sr system in CAIs appears

  14. MicroRNA-146a inhibits glioma development by targeting Notch1.

    PubMed

    Mei, Jie; Bachoo, Robert; Zhang, Chun-Li

    2011-09-01

    Dysregulated epidermal growth factor receptor (EGFR) signaling through either genomic amplification or dominant-active mutation (EGFR(vIII)), in combination with the dual inactivation of INK4A/ARF and PTEN, is a leading cause of gliomagenesis. Our global expression analysis for microRNAs revealed that EGFR activation induces miR-146a expression, which is further potentiated by inactivation of PTEN. Unexpectedly, overexpression of miR-146a attenuates the proliferation, migration, and tumorigenic potential of Ink4a/Arf(-/-) Pten(-/-) Egfr(vIII) murine astrocytes. Its ectopic expression also inhibits the glioma development of a human glioblastoma cell line in an orthotopic xenograft model. Such an inhibitory function of miR-146a on gliomas is largely through downregulation of Notch1, which plays a key role in neural stem cell maintenance and is a direct target of miR-146a. Accordingly, miR-146a modulates neural stem cell proliferation and differentiation and reduces the formation and migration of glioma stem-like cells. Conversely, knockdown of miR-146a by microRNA sponge upregulates Notch1 and promotes tumorigenesis of malignant astrocytes. These findings indicate that, in response to oncogenic cues, miR-146a is induced as a negative-feedback mechanism to restrict tumor growth by repressing Notch1. Our results provide novel insights into the signaling pathways that link neural stem cells to gliomagenesis and may lead to new strategies for treating brain tumors.

  15. MicroRNA-146b: A Novel Biomarker and Therapeutic Target for Human Papillary Thyroid Cancer

    PubMed Central

    Chou, Chen-Kai; Liu, Rue-Tsuan; Kang, Hong-Yo

    2017-01-01

    Papillary thyroid cancer (PTC) is the most common tumor subtype of thyroid cancer. However, not all PTCs are responsive to current surgical and radioiodine treatment. The well-established clinical prognostic factors include tumor size, lymph node/distal metastasis, and extrathyroidal invasion. The RET/PTC-RAS-BRAF linear molecular signaling cascade is known to mediate PTC pathogenesis. However, whether presence of BRAF mutation, the most common genetic alteration in PTC, can affect PTC behavior and prognosis is controversial. MicroRNAs (miRNAs) have been labeled as promising molecular prognostic markers in several tumor types. Our recent studies demonstrated that microRNA-146b (miR-146b) deregulation is associated with PTC aggressiveness and prognosis. Here we summarize the current knowledge related to the functional roles, regulated target genes, and clinical applications of miR-146b in PTC and discuss how these studies provide insights into the key role of miR-146b as an oncogenic regulator promoting cellular transformation as well as a prognosis marker for tumor recurrence in PTC. In conjunction with the current perspectives on miRNAs in a wide variety of human cancers, this review will hopefully translate these updated findings on miR-146b into more comprehensive diagnostic or prognostic information regarding treatment in PTC patients before surgical intervention and follow up strategies. PMID:28294980

  16. Hsa-miR-146a-5p modulates androgen-independent prostate cancer cells apoptosis by targeting ROCK1.

    PubMed

    Xu, Bin; Huang, Yeqing; Niu, Xiaobing; Tao, Tao; Jiang, Liang; Tong, Na; Chen, Shuqiu; Liu, Ning; Zhu, Weidong; Chen, Ming

    2015-12-01

    MicroRNAs (miRNAs) have been demonstrated playing important roles in the procession of prostate cancer cells transformation from androgen-dependence to androgen-independence. We conducted the miRNA microarray and realtime PCR analyses in both androgen-dependent (ADPC) and androgen-independent prostate cancer (AIPC) tissues. We also explored the role of hsa-miR-146a-5p (miR-146a) in MSKCC prostate cancer clinical database. Moreover, the impact of miR-146a on prostate cancer cells apoptosis were detected by Hoechst staining and fluorescence-activated cell sorter (FACS). Its target is predicted by DIANA LAB online database and the result was assumed by western blotting and luciferase assay. We demonstrated that miR-146a was down-regulated in AIPC tissues and cell lines compared to that in the ADPC tissues. In MSKCC data re-analyses, we found that miR-146a was underexpressed in metastatic prostate cancer tissues and those with Gleason score >8, moreover, low level of miR-146a represented a high biochemical relapse rate after radical prostatectomy. In the functional analyses, we transfected miR-146a mimics into CPRC cell lines and found miR-146a induced cells apoptosis. In mechanic analyses, we found that miR-146a inhibited the basal level of Rho-associated, coiled-coil containing protein kinase 1 (ROCK1) expression by targeting its 3'UTR and an inverse correlation of expression between miR-146a and ROCK1 was observed. Moreover, caspase 3 activity was stimulated by miR-146a overexpression. miR-146a has a critical role in the process of AIPC prostate cancer cells apoptosis through regulation of ROCK/Caspase 3 pathway. Targeting this pathway may be a promising therapeutic strategy for future personalized anti-cancer treatment. © 2015 Wiley Periodicals, Inc.

  17. Selective targeting of liver cancer with the endothelial marker CD146

    PubMed Central

    Thomann, Stefan; Longerich, Thomas; Bazhin, Alexandr V.; Mier, Walter; Schemmer, Peter; Ryschich, Eduard

    2014-01-01

    Hepatocellular carcinomas are well-vascularized tumors; the endothelial cells in these tumors have a specific phenotype. Our aim was to develop a new approach for tumor-specific drug delivery with monoclonal antibody targeting of endothelial ligands. CD146, a molecule expressed on the endothelial surface of hepatocellular carcinoma, was identified as a promising candidate for targeting. In the present study, endothelial cells immediately captured circulating anti-CD146 (ME-9F1) antibody, while antibody binding in tumors was significantly higher than in hepatic endothelium. Macroscopically, after intravenous injection, there were no differences in the mean accumulation of anti-CD146 antibody in tumor compared to liver tissue, due to a compensating higher blood vessel density in the liver tissue. Additional blockade of nontumoral epitopes and intra-arterial administration, improved selective antibody capture in the tumor microvasculature and largely prevented antibody distribution in the lung and liver. The potential practical use of this approach was demonstrated by imaging of radionuclide-labeled ME-9F1 antibody, which showed excellent tumor-selective uptake. Our results provide a promising principle for the use of endothelial markers for intratumoral drug delivery. Tumor endothelium–based access might offer new opportunities for the imaging and therapy of hepatocellular carcinoma and other liver malignancies. PMID:25238265

  18. CD146-targeted immunoPET and NIRF Imaging of Hepatocellular Carcinoma with a Dual-Labeled Monoclonal Antibody

    PubMed Central

    Hernandez, Reinier; Sun, Haiyan; England, Christopher G.; Valdovinos, Hector F.; Ehlerding, Emily B.; Barnhart, Todd E.; Yang, Yunan; Cai, Weibo

    2016-01-01

    Overexpression of CD146 has been correlated with aggressiveness, recurrence rate, and poor overall survival in hepatocellular carcinoma (HCC) patients. In this study, we set out to develop a CD146-targeting probe for high-contrast noninvasive in vivo positron emission tomography (PET) and near-infrared fluorescence (NIRF) imaging of HCCs. YY146, an anti-CD146 monoclonal antibody, was employed as a targeting molecule to which we conjugated the zwitterionic near-infrared fluorescence (NIRF) dye ZW800-1 and the chelator deferoxamine (Df). This enabled labeling of Df-YY146-ZW800 with 89Zr and its subsequent detection using PET and NIRF imaging, all without compromising antibody binding properties. Two HCC cell lines expressing high (HepG2) and low (Huh7) levels of CD146 were employed to generate subcutaneous (s.c.) and orthotopic xenografts in athymic nude mice. Sequential PET and NIRF imaging performed after intravenous injection of 89Zr-Df-YY146-ZW800 into tumor-bearing mice unveiled prominent and persistent uptake of the tracer in HepG2 tumors that peaked at 31.65 ± 7.15 percentage of injected dose per gram (%ID/g; n=4) 72 h post-injection. Owing to such marked accumulation, tumor delineation was successful by both PET and NIRF, which facilitated the fluorescence image-guided resection of orthotopic HepG2 tumors, despite the relatively high liver background. CD146-negative Huh7 and CD146-blocked HepG2 tumors exhibited significantly lower 89Zr-Df-YY146-ZW800 accretion (6.1 ± 0.5 and 8.1 ± 1.0 %ID/g at 72 h p.i., respectively; n=4), demonstrating the CD146-specificity of the tracer in vivo. Ex vivo biodistribution and immunofluorescent staining corroborated the accuracy of the imaging data and correlated tracer uptake with in situ CD146 expression. Overall, 89Zr-Df-YY146-ZW800 showed excellent properties as a PET/NIRF imaging agent, including high in vivo affinity and specificity for CD146-expressing HCC. CD146-targeted molecular imaging using dual-labeled YY146

  19. MiR-146b protects cardiomyocytes injury in myocardial ischemia/reperfusion by targeting Smad4

    PubMed Central

    Di, Yun-Feng; Li, De-Cai; Shen, Yan-Qing; Wang, Chun-Lei; Zhang, Da-Yong; Shang, An-Quan; Hu, Teng

    2017-01-01

    MicroRNAs, a class of small and non-encoding RNAs that transcriptionally or post-transcriptionally modulate the expression of their target genes, have been implicated as critical regulatory molecules in many cardiovascular diseases, including ischemia-/reperfusion-induced cardiac injury. In the present study, we report on the role of miR-146b in myocardial I/R injury and the underlying cardio-protective mechanism. Antagomir-146b was used to explore the effects of miR-146b on cardiac ischemia/reperfusion injury (30 min ischemia followed by 180 min reperfusion). As predicted, miR-146b overexpression significantly reduced the infarct size and cardiomyocytes apoptosis and release of creatine kinase and lactate dehydrogenase. In addition, miR-146b attenuated H9c2 cell apoptosis. Furthermore, Smad4 was predicted and verified as a potential miR-146b target using bioinformatics and luciferase assay. In summary, this study demonstrated that miR-146b plays a critical protective role in cardiac ischemic injury and may provide a new therapeutic approach for the treatment of myocardial I/R injury.

  20. The evolution of melasma therapy: targeting melanosomes using low-fluence Q-switched neodymium-doped yttrium aluminium garnet lasers.

    PubMed

    Kauvar, Arielle N B

    2012-06-01

    Melasma is an acquired disorder of pigmentation that commonly affects women with phototypes III-V, and it has a negative impact on the quality of life in affected individuals. It presents clinically as symmetric tan or brown patches on the face, most often involving the forehead, cheeks, perioral region, and periorbital region. On histologic examination, there is increased melanin in the epidermis and/or an increased number of melanosomes in the dermis, with a normal number of highly melanized and dendritic melanocytes. The mainstay of treatment is the use of sunscreen along with topical medications that suppress melanogenesis. Clearance is usually incomplete and recurrences or exacerbations are frequent, probably because of the poor efficacy in clearing dermal melanosomes. Treatment with high-energy pigment-specific lasers, ablative resurfacing lasers, and fractional lasers results in an unacceptably high rate of postinflammatory hyper- and hypopigmentation and rebound melasma. Recently, promising results have been achieved with low-fluence Q-switched neodymium-doped yttrium aluminium garnet laser treatment, which can selectively target dermal melanosomes without producing inflammation or epidermal damage, in all skin phototypes. This article reviews the current treatment modalities for melasma, the rationale for using and the clinical results of combination therapy with low-fluence Q-switched neodymium-doped yttrium aluminium garnet lasers. Copyright © 2012 Elsevier Inc. All rights reserved.

  1. MicroRNA-146a expression inhibits the proliferation and promotes the apoptosis of bronchial smooth muscle cells in asthma by directly targeting the epidermal growth factor receptor.

    PubMed

    Zhang, Yanxia; Xue, Yan; Liu, Yan; Song, Guodong; Lv, Guofeng; Wang, Yongqiang; Wang, Yijiang; Li, Xiang; Yang, Leiying

    2016-08-01

    The present study aimed to determine the expression of microRNA-146a (miR-146a) in the plasma of children with asthma, and to investigate the effect of miR-146a on the proliferation and apoptosis of bronchial smooth muscle cells (BSMCs). Reverse transcription-quantitative polymerase chain reaction was used to determine the expression levels of miR-146a mimics and its inhibitor. A Cell Counting kit-8 assay was performed to examine the proliferation of BSMCs. Caspase-3/7 activity was determined using a Caspase-Glo 3/7 kit. To measure the expression levels of proteins associated with apoptosis, western blotting was performed. The target gene of miR-146a was identified using a dual-luciferase reporter assay. The plasma levels of miR-146a in children with asthma were significantly higher compared with those in healthy children. Enhanced miR-146a expression inhibited the proliferation of BSMCs. BSMC apoptosis was promoted by miR-146a. The mechanism underlying the miR-146a-induced promotion of BSMC apoptosis may be its direct targeting of epidermal growth factor receptor (EGFR), which affects downstream signaling pathways. In conclusion, miR-146a expression in asthma inhibits the proliferation and promotes the apoptosis of BSMCs by direct targeting of EGFR.

  2. Targeting CD146 with a 64Cu-labeled antibody enables in vivo immunoPET imaging of high-grade gliomas

    PubMed Central

    Yang, Yunan; Hernandez, Reinier; Rao, Jun; Yin, Li; Qu, Yazhuo; Wu, Jinrong; England, Christopher G.; Graves, Stephen A.; Lewis, Christina M.; Wang, Pu; Meyerand, Mary E.; Nickles, Robert J.; Bian, Xiu-wu; Cai, Weibo

    2015-01-01

    Given the highly heterogeneous character of brain malignancies and the associated implication for its proper diagnosis and treatment, finding biomarkers that better characterize this disease from a molecular standpoint is imperative. In this study, we evaluated CD146 as a potential molecular target for diagnosis and targeted therapy of glioblastoma multiforme (GBM), the most common and lethal brain malignancy. YY146, an anti-CD146 monoclonal antibody, was generated and radiolabeled for noninvasive positron-emission tomography (PET) imaging of orthotopic GBM models. 64Cu-labeled YY146 preferentially accumulated in the tumors of mice bearing U87MG xenografts, which allowed the acquisition of high-contrast PET images of small tumor nodules (∼2 mm). Additionally, we found that tumor uptake correlated with the levels of CD146 expression in a highly specific manner. We also explored the potential therapeutic effects of YY146 on the cancer stem cell (CSC) and epithelial-to-mesenchymal (EMT) properties of U87MG cells, demonstrating that YY146 can mitigate those aggressive phenotypes. Using YY146 as the primary antibody, we performed histological studies of World Health Organization (WHO) grades I through IV primary gliomas. The positive correlation found between CD146-positive staining and high tumor grade (χ2 = 9.028; P = 0.029) concurred with the GBM data available in The Cancer Genome Atlas (TCGA) and validated the clinical value of YY146. In addition, we demonstrate that YY146 can be used to detect CD146 in various cancer cell lines and human resected tumor tissues of multiple other tumor types (gastric, ovarian, liver, and lung), indicating a broad applicability of YY146 in solid tumors. PMID:26553993

  3. Using a neodymium magnet to target delivery of ferumoxide-labeled human neural stem cells in a rat model of focal cerebral ischemia.

    PubMed

    Song, Miyeoun; Kim, Young-Ju; Kim, Yoon-ha; Roh, Jina; Kim, Seung U; Yoon, Byung-Woo

    2010-05-01

    Efficiency of targeted delivery of stem cells via transplantation by intravenous injection is limited because of rapid clearance. Thus, more effective, newer methods are required. We hypothesized that combining the use of ferumoxide labeling and magnetic fields could enhance targeted delivery of stem cells. The effects of a magnetic field on proliferation, viability, and differentiation of human neural stem cells (NSCs) were determined in culture, and the results indicated that the difference between control and cultures exposed to a magnetic field were insignificant. To assess migration in vitro, ferumoxide-labeled cells were seeded into a culture dish that had a neodymium magnet below its center, and the labeled NSCs were found to aggregate above the magnet. To investigate targeted delivery of NSCs in vivo, rats were separated into three groups: ischemia only (IO), ischemia with injection of ferumoxide-labeled cells (IC), and ischemia with injection of labeled cells and magnet exposure (ICM). Twenty-four hours after middle cerebral artery occlusion (MCAo), labeled human NSCs were injected into the tail vein. Seven days after MCAo, ICM rats had a larger number and greater distribution of Prussian blue-positive NSCs as compared with controls. In addition, infarct volume in ICM rats was significantly reduced. Our study suggests that this use of a magnetic field may be useful for improving the efficacy of targeted migration of stem cells in stem-based cell therapy in ischemic brain injury.

  4. Diazoxide potentiates mesenchymal stem cell survival via NF-κB-dependent miR-146a expression by targeting Fas

    PubMed Central

    Suzuki, Yoko; Kim, Ha Won; Ashraf, Muhammad

    2010-01-01

    We have previously reported that preconditioning of bone marrow-derived mesenchymal stem cells (MSCs) with diazoxide (DZ) significantly improved cell survival via NF-κB signaling. Since micro-RNAs (miRNAs) are critical regulators of a wide variety of biological events, including apoptosis, proliferation, and differentiation, it is likely that DZ-induced survival is mediated by miRNAs. Here we show that miR-146a expressed during preconditioning with DZ is a key regulator of stem cell survival. Treatment of MSCs with DZ (200 μM) markedly increased miR-146a expression and promoted cell survival, as evaluated by lactate dehydrogenase release and transferase-mediated dUTP nick-end labeling staining. Interestingly, blocking NF-κB by IKK-γ NEMO binding domain inhibitor peptide did not induce miR-146a expression, indicating NF-κB regulates miR-146a expression. Moreover, blockade of miR-146a expression by antisense miR-146a inhibitor abolished DZ-induced cytoprotective effects, suggesting a critical role of miR-146a in MSC survival. Computational analysis found a consensus putative target site of miR-146a relevant to apoptosis in the 3′ untranslated region of Fas mRNA. The role of Fas as a target gene was substantiated by abrogation of miR-146a, which markedly increased Fas protein expression. This was verified by luciferase reporter assay, which showed that forced expression of miR-146a downregulated Fas expression via targeting its 3′-UTR of this gene. Taken together, these data demonstrated that cytoprotection afforded by preconditioning of MSCs with DZ was regulated by miR-146a induction, which may be a novel therapeutic target in cardiac ischemic diseases. PMID:20656888

  5. Diazoxide potentiates mesenchymal stem cell survival via NF-kappaB-dependent miR-146a expression by targeting Fas.

    PubMed

    Suzuki, Yoko; Kim, Ha Won; Ashraf, Muhammad; Haider, Husnain Kh

    2010-10-01

    We have previously reported that preconditioning of bone marrow-derived mesenchymal stem cells (MSCs) with diazoxide (DZ) significantly improved cell survival via NF-κB signaling. Since micro-RNAs (miRNAs) are critical regulators of a wide variety of biological events, including apoptosis, proliferation, and differentiation, it is likely that DZ-induced survival is mediated by miRNAs. Here we show that miR-146a expressed during preconditioning with DZ is a key regulator of stem cell survival. Treatment of MSCs with DZ (200 μM) markedly increased miR-146a expression and promoted cell survival, as evaluated by lactate dehydrogenase release and transferase-mediated dUTP nick-end labeling staining. Interestingly, blocking NF-κB by IKK-γ NEMO binding domain inhibitor peptide did not induce miR-146a expression, indicating NF-κB regulates miR-146a expression. Moreover, blockade of miR-146a expression by antisense miR-146a inhibitor abolished DZ-induced cytoprotective effects, suggesting a critical role of miR-146a in MSC survival. Computational analysis found a consensus putative target site of miR-146a relevant to apoptosis in the 3' untranslated region of Fas mRNA. The role of Fas as a target gene was substantiated by abrogation of miR-146a, which markedly increased Fas protein expression. This was verified by luciferase reporter assay, which showed that forced expression of miR-146a downregulated Fas expression via targeting its 3'-UTR of this gene. Taken together, these data demonstrated that cytoprotection afforded by preconditioning of MSCs with DZ was regulated by miR-146a induction, which may be a novel therapeutic target in cardiac ischemic diseases.

  6. Metals Fact Sheet: Neodymium

    SciTech Connect

    1992-11-01

    Neodymium was discovered in 1898 when it was separated from {open_quotes}dydimium,{close_quotes} a praseodymium-neodymium compound that was thought to be only one element. {open_quotes}Neodymium{close_quotes} is derived from the Greek words {open_quotes}neos{close_quotes} and {open_quotes}didymos,{close_quotes} which translates to {open_quotes}new twin.{close_quotes} This article discusses sources and applications of the element, and reviews world reserves and demands. Price trends in the commodity are also noted.

  7. Increased miR-146a in gastric cancer directly targets SMAD4 and is involved in modulating cell proliferation and apoptosis.

    PubMed

    Xiao, Bin; Zhu, En-Dong; Li, Na; Lu, Dong-Shui; Li, Wei; Li, Bo-Sheng; Zhao, Yong-Liang; Mao, Xu-Hu; Guo, Gang; Yu, Pei-Wu; Zou, Quan-Ming

    2012-02-01

    MicroRNAs (miRNAs) have emerged as important gene regulators and are recognized as oncogenes or tumor suppressor genes in carcinogenesis. Gastric cancer is one of the most common malignant diseases worldwide. Our previous studies have revealed that miR-146a is upregulated in gastric epithelial cells infected with Helicobacter pylori (H. pylori) and in mucosal tissues from H. pylori-positive patients. However, the role of miR-146a in gastric cancer is largely unknown. In the current study, we showed that miR-146a was upregulated in 20 gastric cancer tissues compared with matched non-tumor adjacent tissues by quantitative RT-PCR. Furthermore, ectopic expression of miR-146a could improve cell proliferation in vitro by using Cell Counting kit 8 (CCK-8). We also found that miR-146a inhibited apoptosis of gastric cancer cells by flow cytometry (FCM) and Caspase-Glo® 3/7 assay. Using target prediction algorithms, luciferase reporter assay and Western blot assay, SMAD family member 4 (SMAD4) was identified as a target gene of miR-146a in gastric cancer. Moreover, an inverse correlation was observed between the expression of SMAD4 mRNA and miR-146a in gastric cancer tissues (R=-0.731, P=0.039, Pearson's correlation). Taken together, our results provide important evidence that miR-146a can directly target SMAD4, and suggest that miR-146a may play a role in the development of gastric cancer by modulating cell proliferation and apoptosis. miR-146a could serve as a potential biomarker and therapeutic target against gastric cancer.

  8. Effects of microRNA-146a on the proliferation and apoptosis of human osteoarthritis chondrocytes by targeting TRAF6 through the NF-κB signaling pathway.

    PubMed

    Zhong, Jun-Hua; Li, Jing; Liu, Cui-Fang; Liu, Ning; Bian, Rui-Xiang; Zhao, Shou-Mei; Yan, Shu-Yi; Zhang, Yong-Bing

    2017-03-17

    This study aims to investigate the effects of microRNA-146a (miR-146a) on the proliferation and apoptosis of human osteoarthritis (OA) chondrocytes by targeting TRAF6 through NF-κB signaling pathway. Human normal and OA chondrocytes were selected and divided into the normal group, blank group, negative control (NC) group, miR-146a mimics group, miR-146a inhibitors, miR-146a inhibitor + si-TRAF6 group and si-TRAF6 group. Quantitative real-time polymerase chain reaction (qRT-PCR) was applied to detect the expressions of miR-146a, TRAF6 mRNA and NF-κB mRNA. Western blotting was used to detect the protein expressions of TRAF6 and NF-κB. CCK-8 assay and flow cytometry were used to detect cell proliferation and apoptosis. Compared with normal chondrocytes, the expression of miR-146a decreased, while the mRNA and protein expressions of TRAF6 and NF-κB increased in OA chondrocytes. OA chondrocytes had a lower proliferation rate and a higher apoptosis rate than normal chondrocytes. Compared with the blank, NC and si-TRAF6 groups, the expression of miR-146a increased in the miR-146a mimics group, but decreased in the miR-146a inhibitors and miR-146a inhibitor + si-TRAF6 groups. Compared with the blank, NC and miR-146a inhibitor + si-TRAF6 groups, the mRNA and protein expressions of TRAF6 and NF-κB decreased, cell proliferation rate increased and cell apoptosis rate decreased in the miR-146a mimics and si-TRAF6 groups, while opposite trends were observed in the miR-146a inhibitors group. Our study suggests that miR-146a could promote proliferation and inhibit apoptosis of OA chondrocytes by inhibiting TRAF6 expression and suppressing the activation of NF-κB signaling pathway.

  9. A Variant in the Precursor of MicroRNA-146a is Responsible for Development of Erectile Dysfunction in Patients with Chronic Prostatitis via Targeting NOS1

    PubMed Central

    Ding, Jian; Tang, Yuxin; Tang, Zhengyan; Zhang, Xiangyang; Wang, Guilin

    2017-01-01

    Background The morbidity of erectile dysfunction (ED) has been found to be substantially increased in patients with chronic prostatitis (CP). Accumulating evidence shows that single-nucleotide polymorphism (SNP) located in pre-miRNA or mature microRNA may affect the processing of microRNA (miRNA) and alter the expression of the miRNA, as well as its target gene. In this study we investigated the association between rs2910164 G/C polymorphism and risk of ED in patients with CP, as well as the underlying molecular mechanism. Material/Methods Computational analysis was used to search for the target of miR-146a, and the luciferase reporter assay system was used to validate NOS1 to be the target gene of miR-146a. We also treated PC-3 cells with miR-146a mimics/inhibitors to verify the negative regulatory relationship between miR-146a and NOS1, and real-time PCR and Western blot analysis were used to estimate the expression of the NOS1 mRNA and miR-146a. Results The binding site of miR-146a was found to be located within the 3′-UTR of the NOS1 by searching an online miRNA database (www.mirdb.org), and luciferase reporter assay was done to confirm that NOS1 is a direct target gene of miR-146a. We also found that mRNA and protein expression level of NOS1 in PC-3 cells treated with miR-146a mimics and NOS1 siRNA was substantially down-regulated compared with scramble control, while cells treated with miR-146a inhibitors showed increased expression of NOS1. In addition, 705 people were recruited for our research – 342 CP patients with ED and 363 CP patients without ED – and we found that the presence of minor allele of rs2910164 polymorphism is significantly associated with reduced risk of ED in patients with CP. Conclusions The findings indicate a decreased risk of ED in patients with CP who are carriers of miR-146a rs2910164 C allele, and this association might be due to its ability to compromise the expression of miR-146a, and thereby increase the expression of its

  10. A Variant in the Precursor of MicroRNA-146a is Responsible for Development of Erectile Dysfunction in Patients with Chronic Prostatitis via Targeting NOS1.

    PubMed

    Ding, Jian; Tang, Yuxin; Tang, Zhengyan; Zhang, Xiangyang; Wang, Guilin

    2017-02-20

    BACKGROUND The morbidity of erectile dysfunction (ED) has been found to be substantially increased in patients with chronic prostatitis (CP). Accumulating evidence shows that single-nucleotide polymorphism (SNP) located in pre-miRNA or mature microRNA may affect the processing of microRNA (miRNA) and alter the expression of the miRNA, as well as its target gene. In this study we investigated the association between rs2910164 G/C polymorphism and risk of ED in patients with CP, as well as the underlying molecular mechanism. MATERIAL AND METHODS Computational analysis was used to search for the target of miR-146a, and the luciferase reporter assay system was used to validate NOS1 to be the target gene of miR-146a. We also treated PC-3 cells with miR-146a mimics/inhibitors to verify the negative regulatory relationship between miR-146a and NOS1, and real-time PCR and Western blot analysis were used to estimate the expression of the NOS1 mRNA and miR-146a. RESULTS The binding site of miR-146a was found to be located within the 3'-UTR of the NOS1 by searching an online miRNA database (www.mirdb.org), and luciferase reporter assay was done to confirm that NOS1 is a direct target gene of miR-146a. We also found that mRNA and protein expression level of NOS1 in PC-3 cells treated with miR-146a mimics and NOS1 siRNA was substantially down-regulated compared with scramble control, while cells treated with miR-146a inhibitors showed increased expression of NOS1. In addition, 705 people were recruited for our research - 342 CP patients with ED and 363 CP patients without ED - and we found that the presence of minor allele of rs2910164 polymorphism is significantly associated with reduced risk of ED in patients with CP. CONCLUSIONS The findings indicate a decreased risk of ED in patients with CP who are carriers of miR-146a rs2910164 C allele, and this association might be due to its ability to compromise the expression of miR-146a, and thereby increase the expression of its

  11. Neodymium-142 evidence for Hadean mafic crust.

    PubMed

    O'Neil, Jonathan; Carlson, Richard W; Francis, Don; Stevenson, Ross K

    2008-09-26

    Neodymium-142 data for rocks from the Nuvvuagittuq greenstone belt in northern Quebec, Canada, show that some rock types have lower 142Nd/144Nd ratios than the terrestrial standard (epsilon142Nd = -0.07 to -0.15). Within a mafic amphibolite unit, 142Nd/144Nd ratios correlate positively with Sm/Nd ratios and produce a 146Sm-142Nd isochron with an age of 4280(-81)(+53) million years. These rocks thus sample incompatible-element-enriched material formed shortly after Earth formation and may represent the oldest preserved crustal section on Earth.

  12. Inhibition of MicroRNA-146a and Overexpression of Its Target Dihydrolipoyl Succinyltransferase Protect Against Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction.

    PubMed

    Heggermont, Ward A; Papageorgiou, Anna-Pia; Quaegebeur, Annelies; Deckx, Sophie; Carai, Paolo; Verhesen, Wouter; Eelen, Guy; Schoors, Sandra; van Leeuwen, Rick; Alekseev, Sergey; Elzenaar, Ies; Vinckier, Stefan; Pokreisz, Peter; Walravens, Ann-Sophie; Gijsbers, Rik; Van Den Haute, Chris; Nickel, Alexander; Schroen, Blanche; van Bilsen, Marc; Janssens, Stefan; Maack, Christoph; Pinto, Yigal; Carmeliet, Peter; Heymans, Stephane

    2017-08-22

    Cardiovascular diseases remain the predominant cause of death worldwide, with the prevalence of heart failure continuing to increase. Despite increased knowledge of the metabolic alterations that occur in heart failure, novel therapies to treat the observed metabolic disturbances are still lacking. Mice were subjected to pressure overload by means of angiotensin-II infusion or transversal aortic constriction. MicroRNA-146a was either genetically or pharmacologically knocked out or genetically overexpressed in cardiomyocytes. Furthermore, overexpression of dihydrolipoyl succinyltransferase (DLST) in the murine heart was performed by means of an adeno-associated virus. MicroRNA-146a was upregulated in whole heart tissue in multiple murine pressure overload models. Also, microRNA-146a levels were moderately increased in left ventricular biopsies of patients with aortic stenosis. Overexpression of microRNA-146a in cardiomyocytes provoked cardiac hypertrophy and left ventricular dysfunction in vivo, whereas genetic knockdown or pharmacological blockade of microRNA-146a blunted the hypertrophic response and attenuated cardiac dysfunction in vivo. Mechanistically, microRNA-146a reduced its target DLST-the E2 subcomponent of the α-ketoglutarate dehydrogenase complex, a rate-controlling tricarboxylic acid cycle enzyme. DLST protein levels significantly decreased on pressure overload in wild-type mice, paralleling a decreased oxidative metabolism, whereas DLST protein levels and hence oxidative metabolism were partially maintained in microRNA-146a knockout mice. Moreover, overexpression of DLST in wild-type mice protected against cardiac hypertrophy and dysfunction in vivo. Altogether we show that the microRNA-146a and its target DLST are important metabolic players in left ventricular dysfunction. © 2017 American Heart Association, Inc.

  13. MiR-146a-5p inhibits cell proliferation and cell cycle progression in NSCLC cell lines by targeting CCND1 and CCND2

    PubMed Central

    Shen, Yu-Qing; Wang, Hui-Min; Ding, Lei; Gu, Yu-Chen; Lou, Jia-Tao; Zhao, Xin-Tai; Ma, Zhong-Liang; Jin, You-Xin

    2016-01-01

    Previous studies have indicated that miR-146a-5p acts as an oncogene in several types of cancer, yet a tumor suppressor gene in others. In non-small cell lung cancer (NSCLC), one report showed that it was downregulated and played the role of tumor suppressor. However, another study showed that miR-146a-5p was overexpressed in the serum of NSCLC patients compared to healthy controls. Therefore, it is obvious that further study of the function of miR-146a-5p in NSCLC is necessary to fully understand its importance. Herein, we have verified that miR- 146a- 5p acts as a tumor suppressor in NSCLC. Our data revealed that the expression level of miR-146a-5p was significantly decreased in several human NSCLC cell lines, and also less abundant in human NSCLC tissues, when compared with controls. Moreover, we observed that miR-146a-5p could suppress cell proliferation, both in vitro and in vivo. Our results also showed that miR-146a-5p directly targeted the 3′-UTR of CCND1 and CCND2 mRNAs as well as decreased their expression at both mRNA and protein levels, causing cell cycle arrest at the G0/G1 phase. Furthermore, siRNA-mediated downregulation of CCND1 or CCND2 yielded the same effects on proliferation and cell cycle arrest as miR-146a-5p upregulation did in the NSCLC cell lines. We confirmed that the expression of miR-146a-5p had negative relationship with CCND1 or CCND2. Besides, we also found that miR-146a-5p could inhibit tumor growth in xengroft mouse models, and CCND1 and CCND2 were downregulated in miR-146a-5p overexpressed xengroft tumor tissues. In summary, our results demonstrated that miR-146a-5p could suppress the proliferation and cell cycle progression in NSCLC cells by inhibiting the expression of CCND1 and CCND2. PMID:27494902

  14. Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-κB activation

    PubMed Central

    Wu, Dongsheng; Cerutti, Camilla; Lopez-Ramirez, Miguel A; Pryce, Gareth; King-Robson, Josh; Simpson, Julie E; van der Pol, Susanne MA; Hirst, Mark C; de Vries, Helga E; Sharrack, Basil; Baker, David; Male, David K; Michael, Gregory J; Romero, Ignacio A

    2015-01-01

    Pro-inflammatory cytokine-induced activation of nuclear factor, NF-κB has an important role in leukocyte adhesion to, and subsequent migration across, brain endothelial cells (BECs), which is crucial for the development of neuroinflammatory disorders such as multiple sclerosis (MS). In contrast, microRNA-146a (miR-146a) has emerged as an anti-inflammatory molecule by inhibiting NF-κB activity in various cell types, but its effect in BECs during neuroinflammation remains to be evaluated. Here, we show that miR-146a was upregulated in microvessels of MS-active lesions and the spinal cord of mice with experimental autoimmune encephalomyelitis. In vitro, TNFα and IFNγ treatment of human cerebral microvascular endothelial cells (hCMEC/D3) led to upregulation of miR-146a. Brain endothelial overexpression of miR-146a diminished, whereas knockdown of miR-146a augmented cytokine-stimulated adhesion of T cells to hCMEC/D3 cells, nuclear translocation of NF-κB, and expression of adhesion molecules in hCMEC/D3 cells. Furthermore, brain endothelial miR-146a modulates NF-κB activity upon cytokine activation through targeting two novel signaling transducers, RhoA and nuclear factor of activated T cells 5, as well as molecules previously identified, IL-1 receptor-associated kinase 1, and TNF receptor-associated factor 6. We propose brain endothelial miR-146a as an endogenous NF-κB inhibitor in BECs associated with decreased leukocyte adhesion during neuroinflammation. PMID:25515214

  15. Neodymium and strontium isotopic study of Australasian tektites - New constraints on the provenance and age of target materials

    NASA Technical Reports Server (NTRS)

    Blum, Joel D.; Papanastassiou, D. A.; Wasserburg, G. J.; Koeberl, C.

    1992-01-01

    The Nd and Sr isotopic compositions of Australasian tectites (including two flanged Australian tectites, two low-SiO2 Muong Nong-type tectites, and three high-SiO2 Muong Nong-type tectites) and the Nd, Sm, Sr, and Rb concentrations were investigated by isotope-dilution thermal ionization mass spectrometry, and the Sm-Nd and Rb-Sr isotope systematics were used to study the characteristics of the parental material. It is shown that the Nd and Sr isotopic data provide evidence that all Australasian tektites were derived from a single sedimentary formation with a narrow range of stratigraphic ages close to 170 Ma. It is suggested that all of the Australasian tektites were derived from a single impact event and that the australites represent the upper part of a melt sheet ejected at high velocity, whereas the indochinites represent melts formed at a lower level in the target material distributed closer to the area of the impact.

  16. MicroR-146 blocks the activation of M1 macrophage by targeting signal transducer and activator of transcription 1 in hepatic schistosomiasis.

    PubMed

    He, Xing; Tang, Rui; Sun, Yue; Wang, Yan-Ge; Zhen, Kui-Yang; Zhang, Dong-Mei; Pan, Wei-Qing

    2016-11-01

    Schistosomiasis is a chronic disease caused by the parasite of the Schistosoma genus and is characterized by egg-induced hepatic granulomas and fibrosis. Macrophages play a central role in schistosomiasis with several studies highlighting their differentiation into M2 cells involved in the survival of infected mice through limitation of immunopathology. However, little is known regarding the mechanisms of regulating macrophage differentiation. Here, we showed that the early stage of infection by Schistosoma japonicum induced expression of type 1T-helper-cell (Th1) cytokine, interferon-γ (IFN-γ), leading to increase in M1 cells. However, the presence of liver-trapped eggs induced the expression of Th2 cytokines including interleukin-4 (IL-4), IL-10, and IL-13 that upregulated the transcription of miR-146b by activating signal transducer and activator of transcription 3/6 (STAT3/6) that bind to the promoter of the pre-miR-146b gene. We found that the miR-146a/b was significantly upregulated in macrophages during the progression of hepatic schistosomiasis. The elevated miR-146a/b inhibited the IFN-γ-induced differentiation of macrophages to M1 cells through targeting STAT1. Our data indicate the protective roles of miR-146a/b in hepatic schistosomiasis through regulating the differentiation of macrophages into M2 cells.

  17. Targeting miR-146a to Treat Delayed Wound Healing in Human Diabetic Organ-Cultured Corneas

    PubMed Central

    Winkler, Michael A.; Dib, Christian; Ljubimov, Alexander V.; Saghizadeh, Mehrnoosh

    2014-01-01

    Limbal epithelial stem cells (LESC) residing at the corneal periphery are largely responsible for maintaining corneal optical transparency by continuously supplying new corneal epithelial cells, which mature during their radial migration to the central cornea. Diabetes mellitus (DM) affects all the structures of the eye including the cornea. Frequent epithelial erosions, delayed wound healing, and microbial infections are common alterations of the diabetic eye that can result in vision loss. MicroRNAs (miRNAs) are short non-coding oligonucleotides that regulate gene expression by repressing translation. Our purpose was to understand the role of miR-146a in the human limbal versus central corneal epithelial compartment in normal and pathological conditions such as diabetes mellitus. Using quantitative real-time PCR (QPCR) we found miR-146a enrichment in the limbal corneal compartment. This miRNA was also expressed at higher levels in the diabetic vs. normal limbus. Cell migration and wound closure were significantly delayed in normal and diabetic primary limbal epithelial cells (LEC) transfected with miR-146a. Cells treated with miR-146a had decreased levels of phosphorylated (activated) p38 and EGFR, mediators of epithelial wound healing. Conversely, inhibition of miR-146a significantly enhanced cell migration in both normal and diabetic primary LEC and in diabetic organ-cultured corneas by nearly 40% vs. scrambled miRNA control, accompanied by increased phosphorylated signaling intermediates. Transfection of miR-146a in cultured LEC resulted in an increased immunoreactivity for putative LEC markers Frizzled-7 and K15, whereas inhibition of miR-146a decreased their expressions. These data suggest that miR-146a plays a role in LEC maintenance at the corneal periphery, and its expression is downregulated during their migration towards the central cornea and accompanying terminal differentiation. Furthermore, abnormal miR-146a upregulation may be an important

  18. Strontium and neodymium isotope systematics of target rocks and impactites from the El'gygytgyn impact structure: Linking impactites and target rocks

    NASA Astrophysics Data System (ADS)

    Wegner, Wencke; Koeberl, Christian

    2016-12-01

    The 3.6 Ma El'gygytgyn structure, located in northeastern Russia on the Chukotka Peninsula, is an 18 km diameter complex impact structure. The bedrock is formed by mostly high-silica volcanic rocks of the 87 Ma old Okhotsk-Chukotka Volcanic Belt (OCVB). Volcanic target rocks and impact glasses collected on the surface, as well as drill core samples of bedrock and impact breccias have been investigated by thermal ionization mass spectrometry (TIMS) to obtain new insights into the relationships between these lithologies in terms of Nd and Sr isotope systematics. Major and trace element data for impact glasses are added to compare with the composition of target rocks and drill core samples. Sr isotope data are useful tracers of alteration processes and Nd isotopes reveal characteristics of the magmatic sources of the target rocks, impact breccias, and impact glasses. There are three types of target rocks mapped on the surface: mafic volcanics, dacitic tuff and lava of the Koekvun' Formation, and dacitic to rhyolitic ignimbrite of the Pykarvaam Formation. The latter represents the main contributor to the impact rocks. The drill core is divided into a suevite and a bedrock section by the Sr isotope data, for which different postimpact alteration regimes have been detected. Impact glasses from the present-day surface did not suffer postimpact hydrothermal alteration and their data indicate a coherent alteration trend in terms of Sr isotopes with the target rocks from the surface. Surprisingly, the target rocks do not show isotopic coherence with the Central Chukotka segment of the OCVB or with the Berlozhya magmatic assemblage (BMA), a late Jurassic felsic volcanic suite that crops out in the eastern part of the central Chukotka segment of the OCVB. However, concordance for these rocks exists with the Okhotsk segment of the OCVB. This finding argues for variable source magmas having contributed to the build-up of the OCVB.

  19. miR-146a-5p inhibits TNF-α-induced adipogenesis via targeting insulin receptor in primary porcine adipocytes[S

    PubMed Central

    Wu, Di; Xi, Qian-Yun; Cheng, Xiao; Dong, Tao; Zhu, Xiao-Tong; Shu, Gang; Wang, Li-Na; Jiang, Qing-Yan; Zhang, Yong-Liang

    2016-01-01

    TNF-α is a multifunctional cytokine participating in immune disorders, inflammation, and tumor development with regulatory effects on energy metabolism. Our work focused on the function of TNF-α in adipogenesis of primary porcine adipocytes. TNF-α could suppress the insulin receptor (IR) at the mRNA and protein levels. Microarray analysis of TNF-α-treated porcine adipocytes was used to screen out 29 differentially expressed microRNAs (miRNAs), 13 of which were remarkably upregulated and 16 were intensely downregulated. These 29 differentially expressed miRNAs were predicted to mainly participate in the insulin signaling pathway, adipocytokine signaling pathway, and type 2 diabetes mellitus pathway by Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses. miR-146a-5p, reportedly involved in immunity and cancer relevant processes, was one of the most highly differentially expressed miRNAs after TNF-α treatment. Red Oil O staining and TG assay revealed that miR-146a-5p suppressed adipogenesis. A dual-luciferase reporter and siRNA assay verified that miR-146a-5p targeted IR and could inhibit its protein expression. miR-146a-5p was also validated to be involved in the insulin signaling pathway by reducing tyrosine phosphorylation of insulin receptor substrate-1. Our study provides the first evidence of miR-146a-5p targeting IR, which facilitates future studies related to obesity and diabetes using pig models. PMID:27324794

  20. miR-146a-5p inhibits TNF-α-induced adipogenesis via targeting insulin receptor in primary porcine adipocytes.

    PubMed

    Wu, Di; Xi, Qian-Yun; Cheng, Xiao; Dong, Tao; Zhu, Xiao-Tong; Shu, Gang; Wang, Li-Na; Jiang, Qing-Yan; Zhang, Yong-Liang

    2016-08-01

    TNF-α is a multifunctional cytokine participating in immune disorders, inflammation, and tumor development with regulatory effects on energy metabolism. Our work focused on the function of TNF-α in adipogenesis of primary porcine adipocytes. TNF-α could suppress the insulin receptor (IR) at the mRNA and protein levels. Microarray analysis of TNF-α-treated porcine adipocytes was used to screen out 29 differentially expressed microRNAs (miRNAs), 13 of which were remarkably upregulated and 16 were intensely downregulated. These 29 differentially expressed miRNAs were predicted to mainly participate in the insulin signaling pathway, adipocytokine signaling pathway, and type 2 diabetes mellitus pathway by Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses. miR-146a-5p, reportedly involved in immunity and cancer relevant processes, was one of the most highly differentially expressed miRNAs after TNF-α treatment. Red Oil O staining and TG assay revealed that miR-146a-5p suppressed adipogenesis. A dual-luciferase reporter and siRNA assay verified that miR-146a-5p targeted IR and could inhibit its protein expression. miR-146a-5p was also validated to be involved in the insulin signaling pathway by reducing tyrosine phosphorylation of insulin receptor substrate-1. Our study provides the first evidence of miR-146a-5p targeting IR, which facilitates future studies related to obesity and diabetes using pig models. Copyright © 2016 by the American Society for Biochemistry and Molecular Biology, Inc.

  1. Absolute isotopic composition and atomic weight of neodymium using thermal ionization mass spectrometry.

    PubMed

    Zhao, Motian; Zhou, Tao; Wang, Jun; Lu, Hai; Fang, Xiang; Guo, Chunhua; Li, Qiuli; Li, Chaofeng

    2005-01-01

    Synthetic mixtures prepared gravimetrically from highly enriched isotopes of neodymium in the form of oxides of well-defined purity were used to calibrate a thermal ionization mass spectrometer. A new error analysis was applied to calculate the final uncertainty of the atomic weight value. Measurements on natural neodymium samples yielded an absolute isotopic composition of 27.153(19) atomic percent (at.%) 142Nd, 12.173(18) at.% 143Nd, 23.798(12) at.% 144Nd, 8.293(7) at.% 145Nd, 17.189(17) at.% 146Nd, 5.756(8) at.% 148Nd, and 5.638(9) at.% 150Nd, and the atomic weight of neodymium as 144.2415(13), with uncertainties given on the basis of 95% confidence limits. No isotopic fractionation was found in terrestrial neodymium materials.

  2. Separation of samarium and neodymium: a prerequisite for getting signals from nuclear synthesis.

    PubMed

    Maji, Samir; Lahiri, Susanta; Wierczinski, Birgit; Korschinek, Gunther

    2006-12-01

    (146)Sm (T(1/2) = 10(8) y) is a long-lived radionuclide which has been produced in significant amounts during burning in a supernova (SN). Detection of this SN produced long-lived radionuclide on Earth may be helpful for getting information on nuclear synthesis at the time of our solar system's formation. Only accelerator mass spectrometry (AMS) can determine such minute traces of (146)Sm still expected in the Earth's crust. However, the villain of (146)Sm measurement through AMS is its naturally occurring stable isobar (146)Nd which is a million times more abundant than the trace amount of (146)Sm. Therefore an efficient method for the separation of samarium and neodymium is required to measure (146)Sm through AMS. A simple liquid-liquid extraction (LLX) based method for separation of samarium and neodymium has been developed using radiometric simulation. Di-(2-ethylhexyl)phosphoric acid (HDEHP) has been used as the organic reagent. A very high separation factor ( approximately 10(6)) can be achieved when a solution containing samarium and neodymium is reduced by hydroxylamine hydrochloride followed by extraction with 0.1% HDEHP diluted in cyclohexane from 0.025 M HCl solution.

  3. Effect of miR-146 targeted HDMCP up-regulation in the pathogenesis of nonalcoholic steatohepatitis

    PubMed Central

    Chen, Yi-peng; Xiang, Zun; Ding, Jie-xia; Li, You-ming

    2017-01-01

    Backgrounds/Aims Mitochondrial dysfunction plays an important role inthe pathogenesis of nonalcoholic steatohepatitis (NASH), where uncoupling protein (UCP) is actively involved. We previously reported the uncoupling activity of HDMCP and its role in liver steatosis. We now aim to investigate the degree and therapeutic effect of HDMCP in NASH and the regulatory role of miR-146 on HDMCP. Methods NASH animal model was established by feeding BALB/c mice with MCD diet while L02 cell was cultured with high concentration of fatty acid (HFFA) for 72h to mimic the steatosis and inflammation of NASH in-vitro appearance. The steatosis level was assessed by H-E/oil-red staining and serum/supernatant marker detection. The inflammation activity was evaluated by levels of Hepatic activity index, transwell, apoptosis degree (TUNEL/flow cytometry) and serum/supernatant marker. HDMCP level was detected by western blot and miRNA expression was tested by qRT-PCR. NASH severity change was recorded after RNA interference while the regulatory role of miR-146 on HDMCP was confirmed by dual luciferase report system. The H2O2 and ATP levels were measured for mechanism exploration. Results Increased HDMCP expression was identified in NASH animal model and HFFA-72h cultured L02 cell. Moreover, under regulation of miR-146, NASH alleviation was achieved after HDMCP downregulation in both in vivo and in vitro, according to the declination of steatosis and inflammation related markers. Though H2O2 and ATP levels were increased and decreased in NASH models, HDMCP down regulation both increased their levels. Conclusions The miR-146-HDMCP-ATP/H2O2 pathway may provide novel mechanism and treatment option for NASH. PMID:28346483

  4. Chromatographic separation of neodymium isotopes by using chemical exchange process.

    PubMed

    Ismail, I M; Ibrahim, M; Aly, H F; Nomura, M; Fujii, Y

    2011-05-20

    The neodymium isotope effects were investigated in Nd-malate ligand exchange system using the highly porous cation exchange resin SQS-6. The temperature of the chromatographic columns was kept constant at 50°C by temperature controlled water passed through the columns jackets. The separation coefficient of neodymium isotopes, ɛ's, was calculated from the isotopic ratios precisely measured by means of an ICP mass spectrometer equipped with nine collectors as ion detectors. The separation coefficient, ɛ×10(5), were calculated and found to be 1.4, 4.8, 5.4, 10.6, 16.8 and 20.2 for (143)Nd, (144)Nd, (145)Nd, (146)Nd, (148)Nd and (150)Nd, respectively.

  5. Perspectives of a scrapie resistance breeding scheme targeting Q211, S146 and K222 caprine PRNP alleles in Greek goats.

    PubMed

    Kanata, Eirini; Humphreys-Panagiotidis, Cynthia; Giadinis, Nektarios D; Papaioannou, Nikolaos; Arsenakis, Minas; Sklaviadis, Theodoros

    2014-04-09

    The present study investigates the potential use of the scrapie-protective Q211 S146 and K222 caprine PRNP alleles as targets for selective breeding in Greek goats. Genotyping data from a high number of healthy goats with special emphasis on bucks, revealed high frequencies of these alleles, while the estimated probabilities of disease occurrence in animals carrying these alleles were low, suggesting that they can be used for selection. Greek goats represent one of the largest populations in Europe. Thus, the considerations presented here are an example of the expected effect of such a scheme on scrapie occurrence and on stakeholders.

  6. MicroRNA-146a induction during influenza H3N2 virus infection targets and regulates TRAF6 levels in human nasal epithelial cells (hNECs).

    PubMed

    Deng, Yuqin; Yan, Yan; Tan, Kai Sen; Liu, Jing; Chow, Vincent T; Tao, Ze-Zhang; Wang, De-Yun

    2017-03-15

    We have previously shown that human nasal epithelial cells (hNECs) are highly permissive cells for respiratory viruses including influenza A virus (IAV) and respiratory syncytial virus. Recent studies have indicated that microRNAs (miRNAs) are involved in virus-host relationship, and this led us to investigate its essential roles in the in vitro hNECs model derived from multiple donors. By comparing the differential expression of miRNAs upon IAV infection among animal and cell line studies, candidates were selected with focus on the initial immune response. After infection of influenza H3N2 virus, hNECs showed constant increase virus titer at 24-72h post-infection (hpi); accompanied with a significantly elevated level of miR-146a-5p at 72 hpi. The exponential elevation of progeny virus titer correlated with a key influenza sensing Toll-like receptor (TLR)7 pathway. TLR7 downstream gene transcripts, myeloid differentiation primary response gene 88 (MyD88), interferon regulator factor 7 (IRF7), and interferon-β (IFN-β) were significantly upregulated at 48 and 72 hpi, while interleukin-1 receptor-associated kinase 1 (IRAK1) and TNF receptor associated factor-6 (TRAF6) were unchanged. Interestingly, when miR-146a was overexpressed with miRNA mimics prior to H3N2 infection, further decreased transcripts of TRAF6, but not IRAK1, were detected. By using the in vitro hNEC model, we demonstrated that H3N2-induced miR-146a specifically targets and regulates TRAF6 expression; but not IRAK expression in the nasal epithelium. We also found that unlike the cell model studies that lead to our studies, when ran across a heterogeneous model of different individual, miRNA signals were highly varied and the expression of most miRNAs, including miR-146a-5p, was more subdued compared to homogenous cell line model, highlighting a need for a more thorough analysis of miRNA signals and targets in a model more mimicking a clinical influenza infection. Copyright © 2017. Published by

  7. A 6-GW NEODYMIUM GLASS LASER,

    DTIC Science & Technology

    A 6-GW neodymium glass laser with a simple phototropic Q-switch is described. The laser consists of three cylindrical rods in series, each 250 mm...operation (50-80 microsec. repetition frequency), the total output was 200 j. The use of a phototropic liquid switch and large-diameter neodymium glass

  8. Q-Switching in a Neodymium Laser

    ERIC Educational Resources Information Center

    Holgado, Warein; Sola, Inigo J.; Jarque, Enrique Conejero; Jarabo, Sebastian; Roso, Luis

    2012-01-01

    We present a laboratory experiment for advanced undergraduate or graduate laser-related classes to study the performance of a neodymium laser. In the experiment, the student has to build the neodymium laser using an open cavity. After that, the cavity losses are modulated with an optical chopper located inside, so the Q-switching regime is…

  9. Q-Switching in a Neodymium Laser

    ERIC Educational Resources Information Center

    Holgado, Warein; Sola, Inigo J.; Jarque, Enrique Conejero; Jarabo, Sebastian; Roso, Luis

    2012-01-01

    We present a laboratory experiment for advanced undergraduate or graduate laser-related classes to study the performance of a neodymium laser. In the experiment, the student has to build the neodymium laser using an open cavity. After that, the cavity losses are modulated with an optical chopper located inside, so the Q-switching regime is…

  10. Neodymium neutron cross section measurements.

    PubMed

    Barry, D P; Trbovich, M J; Danon, Y; Block, R C; Slovacek, R E; Leinweber, G; Burke, J A; Drindak, N J

    2005-01-01

    Neutron capture and transmission measurements were performed by the time-of-flight technique at the Rensselaer Polytechnic Institute LINAC using metallic neodymium samples. The capture measurements were made at the 25-m-long flight station with a 16-segment NaI(Tl) multiplicity detector, and the transmission measurements were performed at 15 and 25 m flight stations with a 6Li glass scintillation detector. After the data were collected and reduced, resonance parameters were determined by simultaneously fitting the transmission and capture data with the multilevel R-matrix Bayesian code SAMMY. The resonance parameters for all naturally occurring neodymium isotopes lie within the energy range of 1.0-500 eV. The resulting resonance parameters were used to calculate the capture resonance integral with this energy region and were compared to calculations obtained when using the resonance parameters from ENDF-B/VI. The RPI parameters gave a resonance integral value of 32 +/- 0.5 b that is approximately 7% lower than that obtained with the ENDF-B/VI parameters. The current measurements significantly reduce the statistical uncertainties on the resonance parameters when compared with previously published parameters.

  11. Samarium-146 in the early solar system - Evidence from neodymiun in the Allende meteorite

    NASA Technical Reports Server (NTRS)

    Lugmair, G. W.; Shimamura, T.; Lewis, R. S.; Anders, E.

    1983-01-01

    A carbon-chromite fraction from the Allende C3V chondrite shows strikingly large isotopic enrichments of neodymium-142 (0.47 percent) and neodymium-143 (36 percent). Both apparently formed by alpha decay of samarium-146 and samarium-147 (half-lives 1.03 x 10 to the 8th and 1.06 x 10 to the 11th years), but the isotopic enrichment was greatly magnified by recoil of residual nuclei into a carbon film surounding the samarium-bearing grains. These data provide an improved estimate of the original abundance of extinct samarium-146 in the early solar system, Sm-146/Sm-144 = (4.5 + or - 0.5) x 10 to the -3rd, higher than predicted by some models of p-process nucleosynthesis. It may be possible to use this isotopic pair as a chronometer of the early solar system.

  12. Samarium-146 in the early solar system - Evidence from neodymiun in the Allende meteorite

    NASA Technical Reports Server (NTRS)

    Lugmair, G. W.; Shimamura, T.; Lewis, R. S.; Anders, E.

    1983-01-01

    A carbon-chromite fraction from the Allende C3V chondrite shows strikingly large isotopic enrichments of neodymium-142 (0.47 percent) and neodymium-143 (36 percent). Both apparently formed by alpha decay of samarium-146 and samarium-147 (half-lives 1.03 x 10 to the 8th and 1.06 x 10 to the 11th years), but the isotopic enrichment was greatly magnified by recoil of residual nuclei into a carbon film surounding the samarium-bearing grains. These data provide an improved estimate of the original abundance of extinct samarium-146 in the early solar system, Sm-146/Sm-144 = (4.5 + or - 0.5) x 10 to the -3rd, higher than predicted by some models of p-process nucleosynthesis. It may be possible to use this isotopic pair as a chronometer of the early solar system.

  13. 21 CFR 146.146 - Frozen concentrated orange juice.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 2 2013-04-01 2013-04-01 false Frozen concentrated orange juice. 146.146 Section... Fruit Juices and Beverages § 146.146 Frozen concentrated orange juice. (a) Frozen concentrated orange juice is the food prepared by removing water from the juice of mature oranges as provided in §...

  14. 21 CFR 146.146 - Frozen concentrated orange juice.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Frozen concentrated orange juice. 146.146 Section... Fruit Juices and Beverages § 146.146 Frozen concentrated orange juice. (a) Frozen concentrated orange juice is the food prepared by removing water from the juice of mature oranges as provided in §...

  15. 21 CFR 146.146 - Frozen concentrated orange juice.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 2 2012-04-01 2012-04-01 false Frozen concentrated orange juice. 146.146 Section... Fruit Juices and Beverages § 146.146 Frozen concentrated orange juice. (a) Frozen concentrated orange juice is the food prepared by removing water from the juice of mature oranges as provided in §...

  16. 21 CFR 146.146 - Frozen concentrated orange juice.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 2 2014-04-01 2014-04-01 false Frozen concentrated orange juice. 146.146 Section... Fruit Juices and Beverages § 146.146 Frozen concentrated orange juice. (a) Frozen concentrated orange juice is the food prepared by removing water from the juice of mature oranges as provided in §...

  17. 21 CFR 146.146 - Frozen concentrated orange juice.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Frozen concentrated orange juice. 146.146 Section... Fruit Juices and Beverages § 146.146 Frozen concentrated orange juice. (a) Frozen concentrated orange juice is the food prepared by removing water from the juice of mature oranges as provided in §...

  18. Electrolysis of neodymium oxide. Final report for the period August 19, 1991 through February 28, 1997

    SciTech Connect

    Keller, R.; Larimer, K.T.

    1997-05-01

    The objective of this research was to develop an electrolytic process for the continuous and economic production of neodymium alloys from neodymium oxide. The electrolysis of neodymium oxide continued to show promise for implementation as a low-cost process to produce high- quality neodymium or neodymium-iron alloy.

  19. Radio-Purification of Neodymium Chloride

    SciTech Connect

    Hans, S.; Yeh, M.; Cumming, J. B.; Hahn, R. L.

    2011-04-27

    Organometallic liquid scintillator becomes one of the man detection mediums for neutrino experiment. Liquid-liquid extraction is the method of choice for loading metallic ions of interest into the organic solvents at BNL. High purity of all starting materials is essential for the optimization of synthesis. A newly developed 'self-scavenging' technique was applied to purify undesired radioisotopes from the starting metal compound and found to effectively remove thorium and such containments from the neodymium chloride for SNO+.

  20. Segmental irradiation of the bladder with neodymium YAG laser irradiation

    SciTech Connect

    McPhee, M.S.; Mador, D.R.; Tulip, J.; Ritchie, B.; Moore, R.; Lakey, W.H.

    1982-11-01

    The Neodymium YAG laser energy source can be readily adapted for cystoscopic use by some simple modifications of existing urologic equipment. Both the fiberoptic resectoscope and a deflecting cystourethroscope have been adapted for this purpose. Fixation of the fiber tip 1 cm. from the target and use of a divergent beam of 36 degrees allows the delivery of standardized dosage to a relatively large bladder tissue volume. Animal experiments involving 35 mongrel dogs established that repetitive overlapping doses of 200 joules ech can successfully treat a large area of bladder resulting in a full thickness bladder wall injury. This technique has been used in 4 high risk patients with infiltrating bladder cancer without adverse sequelae. The ability to reliably produce a full thickness lesion may give this modality a therapeutic advantage over conventional cautery techniques especially for the treatment of residual infiltrative carcinoma.

  1. Target rapidity baryon distributions in {sup 28}Si + {sup 197}Au and {sup 197}Au + {sup 197}Au collisions at 14.6 and 11.7 A{center_dot}GeV/c

    SciTech Connect

    Sangster, T.C.; Costales, J.B.; Namboodiri, M.N.; E802 Collaboration

    1993-02-25

    Proton and deuteron kinetic energy spectra have been measured at target rapidities for both minimum bias and central collisions of 14.6 A{center_dot}GeV/c {sup 28}Si and 11.7 A{center_dot}GeV/c {sup 197}Au beams with a {sup 197}Au target. The spectra were measured from a low energy threshold of approximately E{sub kin}=35 MeV to well over 200 MeV for laboratory angles of 50{degree} to 130{degree} ({vert_bar}{eta}{vert_bar} {le}0.76). The acceptance-corrected spectra have been fit over a limited range of kinetic energies using a Boltzmann distribution. The integrated yields and the inverse slope parameters are presented as a function of centrality for the {sup 28}Si + {sup 197}Au reaction and as a function of trigger for the {sup 197}Au + {sup 197}Au reaction. These quantities are also compared with the proton spectra generated using both the ARC and RQMD codes.

  2. 12 CFR 146.1 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 1 2013-01-01 2013-01-01 false Definitions. 146.1 Section 146.1 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY FEDERAL MUTUAL SAVINGS ASSOCIATIONS-MERGER, DISSOLUTION, REORGANIZATION, AND CONVERSION § 146.1 Definitions. The terms used in §§ 146.2 and 146.3...

  3. 12 CFR 146.1 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 1 2012-01-01 2012-01-01 false Definitions. 146.1 Section 146.1 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY FEDERAL MUTUAL SAVINGS ASSOCIATIONS-MERGER, DISSOLUTION, REORGANIZATION, AND CONVERSION § 146.1 Definitions. The terms used in §§ 146.2 and 146.3...

  4. 12 CFR 146.1 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 1 2014-01-01 2014-01-01 false Definitions. 146.1 Section 146.1 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY FEDERAL MUTUAL SAVINGS ASSOCIATIONS-MERGER, DISSOLUTION, REORGANIZATION, AND CONVERSION § 146.1 Definitions. The terms used in §§ 146.2 and 146.3...

  5. 17 CFR 146.2 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 1 2012-04-01 2012-04-01 false Definitions. 146.2 Section 146... INDIVIDUALS § 146.2 Definitions. For purposes of this part 146: (a) The term Commission means the Commodity... the Federal Register pursuant to § 146.11(a) of these rules; (i) The term routine use means, with...

  6. Neodymium nanoparticles: biosynthesis and structural analysis.

    PubMed

    Ascencio, J A; Canizal, G; Medina-Flores, A; Bejar, L; Tavera, L; Matamoros, H; Liu, H B

    2006-04-01

    Small metallic nanoparticles of neodymium are obtained by a facile route based on the biosynthesis and the pH conditions that demonstrate the possibility of obtaining particles of 1-8 nm. The size is controlled by synthesis conditions. Smaller clusters were obtained with pH = 5, while for pH = 10 evidences of nanorods productions are found and this opens the perspective to use this rare-earth element for zero and one dimensional based applications. Using transmission electron microscopy techniques, the size distribution and structure are studied. Density functional theory-based calculations allow the determination of the lowest energy configuration, which is based on the hexagonal bulk symmetry. Theoretical models are used to simulate the high resolution transmission electron microscopy to identify the experimental image, determining that the synthesized nanoparticles reach the lowest energy hexagonal configurations.

  7. Neodymium YAG Lasers. Citations from the NTIS data base

    NASA Astrophysics Data System (ADS)

    Carrigan, B.

    1980-07-01

    Federally funded research reports on lasing of neodymium doped yttrium aluminum garnet are cited. Studies on design, fabrication, quantum efficiency, light pulses, stabilization, and testing are covered. Optical pumping, mode locking, frequency conversion, and modulation of these lasers are discussed. Laser applications such as optical communication, range finding, and tracking are included. Safety hazards and radiation damage related to neodymium YAG lasers are also covered. This updated bibliography contains 181 citations, 15 of which are new entries to the previous edition.

  8. Selective recognition of neodymium (III) using ion imprinted polymer particles.

    PubMed

    Krishna, Paramesamangalam Gopi; Gladis, Joseph Mary; Rao, Talasila Prasada; Naidu, Gurijala Ramakrishna

    2005-01-01

    Neodymium (III) ion-imprinted polymer (IIP) materials were prepared by the copolymerization of neodymium (III)-5,7-dichloroquinoline-8-ol-4-vinylpyridine ternary complex with styrene(monomer), divinyl benzene (crosslinking monomer) in the presence of 2,2'-azobisisobutyronitrile (initiator). The synthesis was carried out in 2-methoxy ethanol medium (porogen) and the resultant material was filtered, washed, dried and powdered to form unleached IIP particles. The imprint ion was removed by stirring the above particles with 50% (v/v) HCl for 6 h to obtain leached IIP particles with cavities in the polymer particles. Control polymer (CP) particles were similarly prepared without imprint ion, i.e. neodymium (III). CP, unleached and leached IIP particles were characterized by TLC, IR, microanalysis, XRD and UV-visible spectrophotometric studies. The preconcentration of 5-150 microg of neodymium (III) ions present in 500 ml of solution was possible with as little as 40 mg of neodymium (III) IIP particles in the pH range 7.5-8.0 with a detection limit of 50 ng/l. Five replicate determinations of 25 microg of neodymium (III) present in 500 ml of solution gave a mean absorbance of 0.120 with a relative standard deviation of 2.65%. The imprinting effect of IIP particles was noticed in all preconcentration and selectivity studies when compared with CP particles. Furthermore, the selectivity coefficients of neodymium (III) IIP particles were much higher compared with the reported separation factors for the best liquid-liquid extractants, viz. di-2-ethylhexyl phosphoric acid and 2-ethylhexyl-ethylhexyl phosphonate. Kinetic and isotherm studies during rebinding of neodymium (III) onto IIP particles were also carried out.

  9. Samarium-neodymium evolution of meteorites

    NASA Technical Reports Server (NTRS)

    Prinzhofer, A.; Papanastassiou, D. A.; Wasserburg, G. J.

    1992-01-01

    The feasibility of using Sm-147 and Sm-146 as chronometers was investigated using Sm-Nd data obtained on three meteorites: Ibitira, Morristown, and Acapulco. The results of isotope analyses demonstrate the presence of in situ decay of short-lived Sm-146 in these meteorites with initial abundances of Sm-146/Sm-144 between 0.009 and 0.007 in different meteorites. Precisely defined Sm-147/Nd-143 internal isochrons were obtained yielding ages equal to 4.46 +/-0.02 AE for Ibitira, 4.47 +/-0.02 AE for Morristown, and 4.60 +/-0.03 AE for Acapulco. However, detailed examination of the coupled Sm-147/Nd-143 and Sm-146/Nd-142 parent-daughter systematics and of initial Nd-143/Nd-144 values indicated the presence of inconsistencies in the data in spite of the precise isochrons, indicating the need for care in the interpretation of the parent-daughter systematics, even when they appear well behaved.

  10. 22 CFR 146.230 - Transition plans.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Transition plans. 146.230 Section 146.230... PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Coverage § 146.230 Transition plans. (a) Submission of plans. An institution to which § 146.225 applies and that is composed of more than...

  11. 22 CFR 146.230 - Transition plans.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Transition plans. 146.230 Section 146.230... PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Coverage § 146.230 Transition plans. (a) Submission of plans. An institution to which § 146.225 applies and that is composed of more than...

  12. 22 CFR 146.230 - Transition plans.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Transition plans. 146.230 Section 146.230... PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Coverage § 146.230 Transition plans. (a) Submission of plans. An institution to which § 146.225 applies and that is composed of more than...

  13. 22 CFR 146.300 - Admission.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Admission. 146.300 Section 146.300 Foreign... Recruitment Prohibited § 146.300 Admission. (a) General. No person shall, on the basis of sex, be denied admission, or be subjected to discrimination in admission, by any recipient to which §§ 146.300...

  14. Boundary processes traced by neodymium isotopes

    NASA Astrophysics Data System (ADS)

    Jeandel, C.; Lacan, F.

    2003-04-01

    Continental margins have been identified as preferential sites for removing of reactive elements from the ocean, on the base of U-series measurements (more specifically 231Pa/230Th). This process is called boundary scavenging (Bacon, 1988). Five years of neodymium isotopes data in water masses along the ocean margins (Indonesia, Papua New Guinea, Greenland-Scotland ridge and Labrador Sea) suggests that Nd is transferred from the sediments to the ocean but the reverse also occurs via the so-called boundary scavenging. These processes are only detectable by isotopic ratio measurements because they affect the isotopic signature of the water mass coming in contact with the margin, without changing its concentration. They can involve much higher fluxes than net input processes: for example, the modification of the AAIW signature along the Papua New Guinea slope involves exchange processes only (Lacan and Jeandel, 2001). Since we suspect that such processes not only affect the Nd oceanic chemistry but also the chemical fate of other reactive elements in the ocean, we suggest that the concept of boundary scavenging should be extended to "boundary exchange".

  15. Nonaqueous Synthesis of Gadolinium and Neodymium Nanoparticles

    NASA Astrophysics Data System (ADS)

    Fukuda, R.; Castro, M.; Ho, P.-C.; Attar, S.; Golden, M.; Margosan, D.

    2014-03-01

    Nanoparticles are of great interest due to their magnetic properties, such as superparamagnetism, that are not exhibited by their bulk counterparts. Gd and Nd are being tested by applying the reverse micelle method. The reverse micelle method consists of using a surfactant with a large nonpolar solvent to polar solvent ratio to form spherical cages that control the size of the products. Many studies involving the reverse micelle method employ water as the polar solvent. Since Gd and Nd are highly reactive to water, methanol is used as a replacement with hexane or heptane as the nonpolar solvent. Gadolinium chloride or neodymium nitrate are reduced using sodium borohydride after the reverse micelles encapsulate the rare earth compound. Scanning electron microscopy (SEM) and light microscopy show small, spherical clusters with diameters in the micron range. Higher magnification of the SEM melted the clusters, even after cooling the sample to 87 K. The sample was coated with Pt to prevent melting. Energy dispersive x-ray measurements were conducted to find the chemical composition of the clusters, but the sample signals were too small to make a conclusion. Future growths will use the surfactant DDAB instead of AOT since DDAB is more stable when examined with SEM. Research at California State University-Fresno is supported by NSF DMR-1104544.

  16. Samarium-neodymium direct dating of fluorite mineralization.

    PubMed

    Chesley, J T; Halliday, A N; Scrivener, R C

    1991-05-17

    The direct dating of many styles of hydrothermal mineralization has proved difficult, limiting understanding of the geological processes that lead to crustal fluid flow and the formation of major ore deposits. The hydrothermal mineral fluorite (CaF(2)) displays large variations in rare earth element (REE) abundance and samarium/neodymium ratios within a single vein. Samarium-neodymium dating of fluorite from the classic granite-hosted tin deposits of southwest England demonstrates its use as a precise chronometer of mineralization. The concentrations of light rare earth elements (LREEs) in the fluorites are highly variable and suggest the coeval precipitation of an LREE-rich phase as the most likely cause of the extreme variation in samarium/neodymium ratios.

  17. Neodymium-YAG transscleral cyclophotocoagulation. The role of pigmentation

    SciTech Connect

    Cantor, L.B.; Nichols, D.A.; Katz, L.J.; Moster, M.R.; Poryzees, E.; Shields, J.A.; Spaeth, G.L. )

    1989-08-01

    Using a rabbit model we investigated the role of pigmentation of the ciliary body in obtaining ciliodestruction by neodymium-YAG transscleral cyclophotocoagulation. There was marked destruction of the ciliary body in pigmented rabbit eyes, but no histologic effect was observed in albino rabbit eyes. These findings suggest that pigmentation of the ciliary body is important for obtaining the desired response from neodymium-YAG transscleral cyclophotocoagulation in rabbit eyes by our technique. Further study is necessary to define the role of pigmentation in human eyes in this treatment modality.

  18. New high-strength neodymium phosphate laser glass

    SciTech Connect

    Galagan, B I; Glushchenko, I N; Denker, B I; Kalachev, Yu L; Mikhailov, Viktor A; Sverchkov, S E; Shcherbakov, Ivan A; Kuleshov, N V

    2009-12-31

    A high-strength neodymium laser glass (SNLG) based on an alumoborophosphate composition is developed and synthesised; its physicochemical, spectral, luminescent, and lasing characteristics are studied. It is found that the chemical stability and thermal resistance of the new glass are considerably higher than the corresponding characteristics of known neodymium-doped phosphate laser glasses. Investigations of lasing upon longitudinal diode pumping showed that, due to the higher thermal resistance, the new glass allows one to obtain output powers twice as high as those of industrial GLS22 glass. (active media)

  19. miR-146a promotes the initiation and progression of melanoma by activating Notch signaling

    PubMed Central

    Forloni, Matteo; Dogra, Shaillay Kumar; Dong, Yuying; Conte, Darryl; Ou, Jianhong; Zhu, Lihua Julie; Deng, April; Mahalingam, Meera; Green, Michael R; Wajapeyee, Narendra

    2014-01-01

    Oncogenic mutations in BRAF and NRAS occur in 70% of melanomas. In this study, we identify a microRNA, miR-146a, that is highly upregulated by oncogenic BRAF and NRAS. Expression of miR-146a increases the ability of human melanoma cells to proliferate in culture and form tumors in mice, whereas knockdown of miR-146a has the opposite effects. We show these oncogenic activities are due to miR-146a targeting the NUMB mRNA, a repressor of Notch signaling. Previous studies have shown that pre-miR-146a contains a single nucleotide polymorphism (C>G rs2910164). We find that the ability of pre-miR-146a/G to activate Notch signaling and promote oncogenesis is substantially higher than that of pre-miR-146a/C. Analysis of melanoma cell lines and matched patient samples indicates that during melanoma progression pre-miR-146a/G is enriched relative to pre-miR-146a/C, resulting from a C-to-G somatic mutation in pre-miR-146a/C. Collectively, our results reveal a central role for miR-146a in the initiation and progression of melanoma. DOI: http://dx.doi.org/10.7554/eLife.01460.001 PMID:24550252

  20. Recycling potential of neodymium: the case of computer hard disk drives.

    PubMed

    Sprecher, Benjamin; Kleijn, Rene; Kramer, Gert Jan

    2014-08-19

    Neodymium, one of the more critically scarce rare earth metals, is often used in sustainable technologies. In this study, we investigate the potential contribution of neodymium recycling to reducing scarcity in supply, with a case study on computer hard disk drives (HDDs). We first review the literature on neodymium production and recycling potential. From this review, we find that recycling of computer HDDs is currently the most feasible pathway toward large-scale recycling of neodymium, even though HDDs do not represent the largest application of neodymium. We then use a combination of dynamic modeling and empirical experiments to conclude that within the application of NdFeB magnets for HDDs, the potential for loop-closing is significant: up to 57% in 2017. However, compared to the total NdFeB production capacity, the recovery potential from HDDs is relatively small (in the 1-3% range). The distributed nature of neodymium poses a significant challenge for recycling of neodymium.

  1. Activation cross-sections of deuteron induced nuclear reactions on neodymium up to 50 MeV

    NASA Astrophysics Data System (ADS)

    Tárkányi, F.; Takács, S.; Ditrói, F.; Hermanne, A.; Yamazaki, H.; Baba, M.; Mohammadi, A.; Ignatyuk, A. V.

    2014-04-01

    In the frame of a systematic study of activation cross sections of deuteron induced nuclear reactions on rare earths, the reactions on neodymium for production of therapeutic radionuclides were measured for the first time. The excitation functions of the natNd(d,x) 151,150,149,148m,148g,146,144,143Pm, 149,147,139mNd, 142Pr and 139gCe nuclear reactions were assessed by using the stacked foil activation technique and high resolution γ-spectrometry. The experimental excitation functions were compared to the theoretical predictions calculated with the modified model codes ALICE-IPPE-D and EMPIRE-II-D and with the data in the TENDL-2012 library based on latest version of the TALYS code. The application of the data in the field of medical isotope production and nuclear reaction theory is discussed.

  2. Neodymium neutron transmission and capture measurements and development of a new transmission detector

    NASA Astrophysics Data System (ADS)

    Barry, Devin P.

    Neodymium is a 235U fission product and is important in reactor neutronic calculations. The aim of this thesis is to improve upon the existing neutron cross section data of neodymium. Neutron capture and transmission measurements were performed by the time-of-flight technique at the Rensselaer Polytechnic Institute LINAC using metallic neodymium samples. The capture measurements were made at the 25-m flight station with a 16-segment Nal multiplicity detector, and the transmission measurements were performed at 15-m and 25-m flight stations, respectively, with 6Li glass scintillation detectors. After the data were collected and reduced, resonance parameters were determined by simultaneously fitting the transmission and capture data with the multilevel R-matrix Bayesian code SAMMY. The resonance parameters for all naturally occurring neodymium isotopes were deduced within the energy range of 1.0 eV to 500 eV. The resulting resonance parameters were used to calculate the capture resonance integral with this energy region and were compared to calculations obtained when using the resonance parameters from ENDF-B/VI. The RPI parameters gave a resonance integral value of 32 +/- 1 barns that is approximately 7% lower than that obtained with the ENDF-B/VI parameters. The current measurements significantly reduce the statistical uncertainties on the resonance parameters when compared with previously published parameters. This thesis also explains the resolution function in detail and discusses its importance when fitting experimental data to extract resonance parameters. More accurate resolution function parameters were determined for epithermal transmission and capture measurements by fitting well known resonances in Uranium-238. Improved transmission bare-bounce target in-beam photomultiplier tube (PMT) resolution function parameters were found and compared to those used previously at the RPI LINAC and a marked improvement in the quality of the fits is shown. In addition

  3. 33 CFR 146.201 - Applicability.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 146.201 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES OPERATIONS Mobile Offshore Drilling Units § 146.201 Applicability. This subpart applies to mobile offshore drilling units engaged in OCS activities....

  4. Efficient wide-aperture neodymium glass rod amplifiers

    SciTech Connect

    Potemkin, A K; Zhurin, K A; Kirsanov, A V; Kopelovich, E A; Kuznetsov, M V; Kuz'min, A A; Flat, F A; Khazanov, Efim A; Shaikin, A A

    2011-06-30

    Amplifiers based on neodymium phosphate glass rods 60 - 100 mm in diameter are experimentally studied. The amplifiers are pumped by INP-16/250 tubular flash lamps placed in a universal pump cavity with a two-section mirror reflector. A compact high-voltage capacitive energy storage with a preionisation circuit was developed to supply the lamps. (lasers)

  5. Purification of cerium, neodymium and gadolinium for low background experiments

    NASA Astrophysics Data System (ADS)

    Boiko, R. S.; Barabash, A. S.; Belli, P.; Bernabei, R.; Cappella, F.; Cerulli, R.; Danevich, F. A.; Incicchitti, A.; Laubenstein, M.; Mokina, V. M.; Nisi, S.; Poda, D. V.; Polischuk, O. G.; Tretyak, V. I.

    2014-01-01

    Cerium, neodymium and gadolinium contain double beta active isotopes. The most interesting are 150Nd and 160Gd (promising for 0ν2β search), 136Ce (2β+ candidate with one of the highest Q2β). The main problem of compounds containing lanthanide elements is their high radioactive contamination by uranium, radium, actinium and thorium. The new generation 2β experiments require development of methods for a deep purification of lanthanides from the radioactive elements. A combination of physical and chemical methods was applied to purify cerium, neodymium and gadolinium. Liquid-liquid extraction technique was used to remove traces of Th and U from neodymium, gadolinium and for purification of cerium from Th, U, Ra and K. Co-precipitation and recrystallization methods were utilized for further reduction of the impurities. The radioactive contamination of the samples before and after the purification was tested by using ultra-low-background HPGe gamma spectrometry. As a result of the purification procedure the radioactive contamination of gadolinium oxide (a similar purification efficiency was reached also with cerium and neodymium oxides) was decreased from 0.12 Bq/kg to 0.007 Bq/kg in 228Th, from 0.04 Bq/kg to <0.006 Bq/kg in 226Ra, and from 0.9 Bq/kg to 0.04 Bq/kg in 40K. The purification methods are much less efficient for chemically very similar radioactive elements like actinium, lanthanum and lutetium.

  6. 33 CFR 146.20 - Work vests.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Work vests. 146.20 Section 146.20... SHELF ACTIVITIES OPERATIONS OCS Facilities § 146.20 Work vests. (a) Types of approved work vests. Each buoyant work vest carried under the permissive authority of this section must be approved under— (1) 46...

  7. 33 CFR 146.20 - Work vests.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Work vests. 146.20 Section 146.20... SHELF ACTIVITIES OPERATIONS OCS Facilities § 146.20 Work vests. (a) Types of approved work vests. Each buoyant work vest carried under the permissive authority of this section must be approved under— (1) 46...

  8. 33 CFR 146.20 - Work vests.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Work vests. 146.20 Section 146.20... SHELF ACTIVITIES OPERATIONS OCS Facilities § 146.20 Work vests. (a) Types of approved work vests. Each buoyant work vest carried under the permissive authority of this section must be approved under— (1) 46...

  9. 33 CFR 146.20 - Work vests.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Work vests. 146.20 Section 146.20... SHELF ACTIVITIES OPERATIONS OCS Facilities § 146.20 Work vests. (a) Types of approved work vests. Each buoyant work vest carried under the permissive authority of this section must be approved under— (1) 46...

  10. 19 CFR 146.43 - Domestic status.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Domestic status. 146.43 Section 146.43 Customs... (CONTINUED) FOREIGN TRADE ZONES Status of Merchandise in a Zone § 146.43 Domestic status. (a) General. Domestic status may be granted to merchandise: (1) The growth, product, or manufacture of the U.S. on...

  11. 19 CFR 146.43 - Domestic status.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false Domestic status. 146.43 Section 146.43 Customs... (CONTINUED) FOREIGN TRADE ZONES Status of Merchandise in a Zone § 146.43 Domestic status. (a) General. Domestic status may be granted to merchandise: (1) The growth, product, or manufacture of the U.S. on...

  12. 12 CFR 146.4 - Voluntary dissolution.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 1 2014-01-01 2014-01-01 false Voluntary dissolution. 146.4 Section 146.4... ASSOCIATIONS-MERGER, DISSOLUTION, REORGANIZATION, AND CONVERSION § 146.4 Voluntary dissolution. (a) A Federal savings association's board of directors may propose a plan for dissolution of the association. The...

  13. 12 CFR 146.4 - Voluntary dissolution.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 1 2012-01-01 2012-01-01 false Voluntary dissolution. 146.4 Section 146.4... ASSOCIATIONS-MERGER, DISSOLUTION, REORGANIZATION, AND CONVERSION § 146.4 Voluntary dissolution. (a) A Federal savings association's board of directors may propose a plan for dissolution of the association. The...

  14. 12 CFR 146.4 - Voluntary dissolution.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 1 2013-01-01 2013-01-01 false Voluntary dissolution. 146.4 Section 146.4... ASSOCIATIONS-MERGER, DISSOLUTION, REORGANIZATION, AND CONVERSION § 146.4 Voluntary dissolution. (a) A Federal savings association's board of directors may propose a plan for dissolution of the association. The...

  15. 33 CFR 211.146 - Price.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Price. 211.146 Section 211.146 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE REAL ESTATE... Industrial Facilities § 211.146 Price. No conveyance shall be made for a price less than the fair market...

  16. 19 CFR 146.26 - System review.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false System review. 146.26 Section 146.26 Customs... (CONTINUED) FOREIGN TRADE ZONES Inventory Control and Recordkeeping System § 146.26 System review. The operator shall perform an annual internal review of the inventory control and recordkeeping system and...

  17. 19 CFR 146.26 - System review.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 2 2013-04-01 2013-04-01 false System review. 146.26 Section 146.26 Customs... (CONTINUED) FOREIGN TRADE ZONES Inventory Control and Recordkeeping System § 146.26 System review. The operator shall perform an annual internal review of the inventory control and recordkeeping system and...

  18. 19 CFR 146.26 - System review.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 2 2012-04-01 2012-04-01 false System review. 146.26 Section 146.26 Customs... (CONTINUED) FOREIGN TRADE ZONES Inventory Control and Recordkeeping System § 146.26 System review. The operator shall perform an annual internal review of the inventory control and recordkeeping system and...

  19. 19 CFR 146.26 - System review.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false System review. 146.26 Section 146.26 Customs... (CONTINUED) FOREIGN TRADE ZONES Inventory Control and Recordkeeping System § 146.26 System review. The operator shall perform an annual internal review of the inventory control and recordkeeping system and...

  20. 24 CFR 146.35 - Mediation.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 1 2014-04-01 2014-04-01 false Mediation. 146.35 Section 146.35... ASSISTANCE Investigation, Settlement, and Enforcement Procedures § 146.35 Mediation. (a) HUD shall refer to the Federal Mediation and Conciliation Service, a mediation agency designated by the Secretary of...

  1. 24 CFR 146.35 - Mediation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Mediation. 146.35 Section 146.35... ASSISTANCE Investigation, Settlement, and Enforcement Procedures § 146.35 Mediation. (a) HUD shall refer to the Federal Mediation and Conciliation Service, a mediation agency designated by the Secretary of...

  2. 24 CFR 146.35 - Mediation.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 1 2013-04-01 2013-04-01 false Mediation. 146.35 Section 146.35... ASSISTANCE Investigation, Settlement, and Enforcement Procedures § 146.35 Mediation. (a) HUD shall refer to the Federal Mediation and Conciliation Service, a mediation agency designated by the Secretary of...

  3. 24 CFR 146.35 - Mediation.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Mediation. 146.35 Section 146.35... ASSISTANCE Investigation, Settlement, and Enforcement Procedures § 146.35 Mediation. (a) HUD shall refer to the Federal Mediation and Conciliation Service, a mediation agency designated by the Secretary of...

  4. 24 CFR 146.35 - Mediation.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Mediation. 146.35 Section 146.35... ASSISTANCE Investigation, Settlement, and Enforcement Procedures § 146.35 Mediation. (a) HUD shall refer to the Federal Mediation and Conciliation Service, a mediation agency designated by the Secretary of...

  5. 33 CFR 146.20 - Work vests.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Work vests. 146.20 Section 146.20... SHELF ACTIVITIES OPERATIONS OCS Facilities § 146.20 Work vests. (a) Types of approved work vests. Each buoyant work vest carried under the permissive authority of this section must be approved under— (1)...

  6. 9 CFR 146.22 - Participation.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Participation. 146.22 Section 146.22 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... Commercial Table-Egg Layer Flocks § 146.22 Participation. (a) Participating commercial table-egg layer...

  7. 9 CFR 146.32 - Participation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Participation. 146.32 Section 146.32 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE...-Type Chicken Slaughter Plants § 146.32 Participation. (a) Participating meat-type chicken...

  8. 9 CFR 146.22 - Participation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Participation. 146.22 Section 146.22 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... Commercial Table-Egg Layer Flocks § 146.22 Participation. (a) Participating commercial table-egg layer...

  9. 9 CFR 146.32 - Participation.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Participation. 146.32 Section 146.32 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE...-Type Chicken Slaughter Plants § 146.32 Participation. (a) Participating meat-type chicken...

  10. 19 CFR 146.3 - Customs supervision.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Customs supervision. 146.3 Section 146.3 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) FOREIGN TRADE ZONES General Provisions § 146.3 Customs supervision. (a) Assignment of...

  11. 22 CFR 146.450 - Athletics.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Athletics. 146.450 Section 146.450 Foreign... Activities Prohibited § 146.450 Athletics. (a) General. No person shall, on the basis of sex, be excluded... otherwise be discriminated against in any interscholastic, intercollegiate, club, or intramural athletics...

  12. 22 CFR 146.450 - Athletics.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Athletics. 146.450 Section 146.450 Foreign... Activities Prohibited § 146.450 Athletics. (a) General. No person shall, on the basis of sex, be excluded... otherwise be discriminated against in any interscholastic, intercollegiate, club, or intramural athletics...

  13. 22 CFR 146.450 - Athletics.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Athletics. 146.450 Section 146.450 Foreign... Activities Prohibited § 146.450 Athletics. (a) General. No person shall, on the basis of sex, be excluded... otherwise be discriminated against in any interscholastic, intercollegiate, club, or intramural athletics...

  14. 19 CFR 146.25 - Annual reconciliation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Annual reconciliation. 146.25 Section 146.25 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) FOREIGN TRADE ZONES Inventory Control and Recordkeeping System § 146.25...

  15. 19 CFR 146.25 - Annual reconciliation.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false Annual reconciliation. 146.25 Section 146.25 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) FOREIGN TRADE ZONES Inventory Control and Recordkeeping System § 146.25...

  16. 9 CFR 146.22 - Participation.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Participation. 146.22 Section 146.22 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... Commercial Table-Egg Layer Flocks § 146.22 Participation. (a) Participating commercial table-egg layer...

  17. 9 CFR 146.22 - Participation.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Participation. 146.22 Section 146.22 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... Commercial Table-Egg Layer Flocks § 146.22 Participation. (a) Participating commercial table-egg layer...

  18. 9 CFR 146.22 - Participation.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Participation. 146.22 Section 146.22 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... Commercial Table-Egg Layer Flocks § 146.22 Participation. (a) Participating commercial table-egg layer...

  19. 28 CFR 0.146 - Seals.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 1 2011-07-01 2011-07-01 false Seals. 0.146 Section 0.146 Judicial... Personnel and Certain Administrative Matters § 0.146 Seals. The Director of the Federal Bureau of... the U.S. Marshals Service shall each have custody of the seal pertaining to his...

  20. 28 CFR 0.146 - Seals.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 1 2012-07-01 2012-07-01 false Seals. 0.146 Section 0.146 Judicial... Personnel and Certain Administrative Matters § 0.146 Seals. The Director of the Federal Bureau of... the U.S. Marshals Service shall each have custody of the seal pertaining to his...

  1. 28 CFR 0.146 - Seals.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 1 2014-07-01 2014-07-01 false Seals. 0.146 Section 0.146 Judicial... Personnel and Certain Administrative Matters § 0.146 Seals. The Director of the Federal Bureau of... the U.S. Marshals Service shall each have custody of the seal pertaining to his...

  2. 22 CFR 146.505 - Employment criteria.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Employment in Education Programs or Activities Prohibited § 146.505 Employment criteria. A recipient shall... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Employment criteria. 146.505 Section 146.505 Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS NONDISCRIMINATION ON THE BASIS OF SEX IN...

  3. 22 CFR 146.500 - Employment.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Education Programs or Activities Prohibited § 146.500 Employment. (a) General. (1) No person shall, on the... assistance. (2) A recipient shall make all employment decisions in any education program or activity operated... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Employment. 146.500 Section 146.500...

  4. 9 CFR 146.32 - Participation.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Participation. 146.32 Section 146.32 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE...-Type Chicken Slaughter Plants § 146.32 Participation. (a) Participating meat-type chicken...

  5. 9 CFR 146.31 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Definitions. 146.31 Section 146.31 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE...-Type Chicken Slaughter Plants § 146.31 Definitions. Meat-type chicken. A domesticated chicken grown...

  6. 9 CFR 146.32 - Participation.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Participation. 146.32 Section 146.32 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE...-Type Chicken Slaughter Plants § 146.32 Participation. (a) Participating meat-type chicken...

  7. 9 CFR 146.31 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Definitions. 146.31 Section 146.31 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE...-Type Chicken Slaughter Plants § 146.31 Definitions. Meat-type chicken. A domesticated chicken grown...

  8. 9 CFR 146.32 - Participation.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Participation. 146.32 Section 146.32 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE...-Type Chicken Slaughter Plants § 146.32 Participation. (a) Participating meat-type chicken...

  9. 9 CFR 146.31 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Definitions. 146.31 Section 146.31 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE...-Type Chicken Slaughter Plants § 146.31 Definitions. Meat-type chicken. A domesticated chicken grown...

  10. 9 CFR 146.31 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Definitions. 146.31 Section 146.31 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE...-Type Chicken Slaughter Plants § 146.31 Definitions. Meat-type chicken. A domesticated chicken grown...

  11. 9 CFR 146.31 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Definitions. 146.31 Section 146.31 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE...-Type Chicken Slaughter Plants § 146.31 Definitions. Meat-type chicken. A domesticated chicken grown...

  12. 14 CFR § 1264.146 - Limitations.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 5 2014-01-01 2014-01-01 false Limitations. § 1264.146 Section § 1264.146 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION IMPLEMENTATION OF THE PROGRAM FRAUD CIVIL PENALTIES ACT OF 1986 § 1264.146 Limitations. (a) The notice of hearing with respect to...

  13. 14 CFR 1264.146 - Limitations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Limitations. 1264.146 Section 1264.146 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION IMPLEMENTATION OF THE PROGRAM FRAUD CIVIL PENALTIES ACT OF 1986 § 1264.146 Limitations. (a) The notice of hearing with respect to a claim or...

  14. 22 CFR 146.105 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Definitions. 146.105 Section 146.105 Foreign... ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Introduction § 146.105 Definitions. As used in these Title... bachelor of science degree, whether or not leading to a certificate of any higher degree in the liberal...

  15. 22 CFR 146.105 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Definitions. 146.105 Section 146.105 Foreign... ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Introduction § 146.105 Definitions. As used in these Title... bachelor of science degree, whether or not leading to a certificate of any higher degree in the liberal...

  16. 33 CFR 146.402 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Definitions. 146.402 Section 146... CONTINENTAL SHELF ACTIVITIES OPERATIONS Vessels-Safety and Security Notice of Arrival § 146.402 Definitions... means the names given by the Bureau of Ocean Energy Management, Regulation and Enforcement (BOE) to...

  17. 33 CFR 146.402 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Definitions. 146.402 Section 146... CONTINENTAL SHELF ACTIVITIES OPERATIONS Vessels-Safety and Security Notice of Arrival § 146.402 Definitions... means the names given by the Bureau of Ocean Energy Management, (BOEM) to define the OCS areas used to...

  18. 33 CFR 146.40 - Diving casualties.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Diving casualties. 146.40 Section 146.40 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES OPERATIONS OCS Facilities § 146.40 Diving casualties. Diving related...

  19. 7 CFR 1955.146 - Advertising.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 14 2011-01-01 2011-01-01 false Advertising. 1955.146 Section 1955.146 Agriculture... REGULATIONS (CONTINUED) PROPERTY MANAGEMENT Disposal of Inventory Property General § 1955.146 Advertising. (a... real estate brokers, it is the servicing official's responsibility to ensure adequate advertising...

  20. 7 CFR 1955.146 - Advertising.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 14 2010-01-01 2009-01-01 true Advertising. 1955.146 Section 1955.146 Agriculture... REGULATIONS (CONTINUED) PROPERTY MANAGEMENT Disposal of Inventory Property General § 1955.146 Advertising. (a... real estate brokers, it is the servicing official's responsibility to ensure adequate advertising...

  1. 7 CFR 1955.146 - Advertising.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 14 2014-01-01 2014-01-01 false Advertising. 1955.146 Section 1955.146 Agriculture... REGULATIONS (CONTINUED) PROPERTY MANAGEMENT Disposal of Inventory Property General § 1955.146 Advertising. (a... real estate brokers, it is the servicing official's responsibility to ensure adequate advertising...

  2. 22 CFR 146.540 - Advertising.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Advertising. 146.540 Section 146.540 Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR... Education Programs or Activities Prohibited § 146.540 Advertising. A recipient shall not in any...

  3. 7 CFR 1955.146 - Advertising.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 14 2013-01-01 2013-01-01 false Advertising. 1955.146 Section 1955.146 Agriculture... REGULATIONS (CONTINUED) PROPERTY MANAGEMENT Disposal of Inventory Property General § 1955.146 Advertising. (a... real estate brokers, it is the servicing official's responsibility to ensure adequate advertising...

  4. 22 CFR 146.540 - Advertising.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Advertising. 146.540 Section 146.540 Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR... Education Programs or Activities Prohibited § 146.540 Advertising. A recipient shall not in any...

  5. 22 CFR 146.540 - Advertising.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Advertising. 146.540 Section 146.540 Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR... Education Programs or Activities Prohibited § 146.540 Advertising. A recipient shall not in any...

  6. 22 CFR 146.540 - Advertising.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Advertising. 146.540 Section 146.540 Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR... Education Programs or Activities Prohibited § 146.540 Advertising. A recipient shall not in any...

  7. 7 CFR 1955.146 - Advertising.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 14 2012-01-01 2012-01-01 false Advertising. 1955.146 Section 1955.146 Agriculture... REGULATIONS (CONTINUED) PROPERTY MANAGEMENT Disposal of Inventory Property General § 1955.146 Advertising. (a... real estate brokers, it is the servicing official's responsibility to ensure adequate advertising...

  8. 47 CFR 80.146 - [Reserved

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false 80.146 Section 80.146 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES STATIONS IN THE MARITIME SERVICES Operating Requirements and Procedures Shipboard General Purpose Watches § 80.146...

  9. 47 CFR 80.146 - [Reserved

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 5 2013-10-01 2013-10-01 false 80.146 Section 80.146 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES STATIONS IN THE MARITIME SERVICES Operating Requirements and Procedures Shipboard General Purpose Watches § 80.146...

  10. 47 CFR 80.146 - [Reserved

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 5 2011-10-01 2011-10-01 false 80.146 Section 80.146 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES STATIONS IN THE MARITIME SERVICES Operating Requirements and Procedures Shipboard General Purpose Watches § 80.146...

  11. 47 CFR 80.146 - [Reserved

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 5 2012-10-01 2012-10-01 false 80.146 Section 80.146 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES STATIONS IN THE MARITIME SERVICES Operating Requirements and Procedures Shipboard General Purpose Watches § 80.146...

  12. 47 CFR 80.146 - [Reserved

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 5 2014-10-01 2014-10-01 false 80.146 Section 80.146 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO SERVICES STATIONS IN THE MARITIME SERVICES Operating Requirements and Procedures Shipboard General Purpose Watches § 80.146...

  13. 24 CFR 146.37 - Investigation.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 1 2014-04-01 2014-04-01 false Investigation. 146.37 Section 146... FINANCIAL ASSISTANCE Investigation, Settlement, and Enforcement Procedures § 146.37 Investigation. (a) Investigation and settlement following mediation. (1) HUD shall investigate complaints that are unresolved...

  14. 24 CFR 146.37 - Investigation.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Investigation. 146.37 Section 146... FINANCIAL ASSISTANCE Investigation, Settlement, and Enforcement Procedures § 146.37 Investigation. (a) Investigation and settlement following mediation. (1) HUD shall investigate complaints that are unresolved...

  15. 24 CFR 146.37 - Investigation.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 1 2013-04-01 2013-04-01 false Investigation. 146.37 Section 146... FINANCIAL ASSISTANCE Investigation, Settlement, and Enforcement Procedures § 146.37 Investigation. (a) Investigation and settlement following mediation. (1) HUD shall investigate complaints that are unresolved...

  16. 24 CFR 146.37 - Investigation.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Investigation. 146.37 Section 146... FINANCIAL ASSISTANCE Investigation, Settlement, and Enforcement Procedures § 146.37 Investigation. (a) Investigation and settlement following mediation. (1) HUD shall investigate complaints that are unresolved...

  17. 22 CFR 146.405 - Housing.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Housing. 146.405 Section 146.405 Foreign... Activities Prohibited § 146.405 Housing. (a) Generally. A recipient shall not, on the basis of sex, apply... benefits related to housing, except as provided in this section (including housing provided only to...

  18. 22 CFR 146.405 - Housing.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Housing. 146.405 Section 146.405 Foreign... Activities Prohibited § 146.405 Housing. (a) Generally. A recipient shall not, on the basis of sex, apply... benefits related to housing, except as provided in this section (including housing provided only to...

  19. 22 CFR 146.405 - Housing.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Housing. 146.405 Section 146.405 Foreign... Activities Prohibited § 146.405 Housing. (a) Generally. A recipient shall not, on the basis of sex, apply... benefits related to housing, except as provided in this section (including housing provided only to...

  20. 22 CFR 146.405 - Housing.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Housing. 146.405 Section 146.405 Foreign... Activities Prohibited § 146.405 Housing. (a) Generally. A recipient shall not, on the basis of sex, apply... benefits related to housing, except as provided in this section (including housing provided only to...

  1. 22 CFR 146.405 - Housing.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Housing. 146.405 Section 146.405 Foreign... Activities Prohibited § 146.405 Housing. (a) Generally. A recipient shall not, on the basis of sex, apply... benefits related to housing, except as provided in this section (including housing provided only to...

  2. 22 CFR 146.515 - Compensation.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Compensation. 146.515 Section 146.515 Foreign... Education Programs or Activities Prohibited § 146.515 Compensation. A recipient shall not make or enforce... compensation; (b) Results in the payment of wages to employees of one sex at a rate less than that paid...

  3. 22 CFR 146.515 - Compensation.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Compensation. 146.515 Section 146.515 Foreign... Education Programs or Activities Prohibited § 146.515 Compensation. A recipient shall not make or enforce... compensation; (b) Results in the payment of wages to employees of one sex at a rate less than that paid...

  4. 22 CFR 146.515 - Compensation.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Compensation. 146.515 Section 146.515 Foreign... Education Programs or Activities Prohibited § 146.515 Compensation. A recipient shall not make or enforce... compensation; (b) Results in the payment of wages to employees of one sex at a rate less than that paid...

  5. 21 CFR 133.146 - Grated cheeses.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Grated cheeses. 133.146 Section 133.146 Food and... CONSUMPTION CHEESES AND RELATED CHEESE PRODUCTS Requirements for Specific Standardized Cheese and Related Products § 133.146 Grated cheeses. (a) Description. Grated cheeses is the class of foods prepared by...

  6. 22 CFR 146.430 - Financial assistance.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 22 Foreign Relations 1 2014-04-01 2014-04-01 false Financial assistance. 146.430 Section 146.430... PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Education Programs or Activities Prohibited § 146.430 Financial assistance. (a) General. Except as...

  7. 22 CFR 146.430 - Financial assistance.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Financial assistance. 146.430 Section 146.430... PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Education Programs or Activities Prohibited § 146.430 Financial assistance. (a) General. Except as...

  8. 40 CFR 146.85 - Financial responsibility.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 23 2011-07-01 2011-07-01 false Financial responsibility. 146.85 Section 146.85 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS... to Class VI Wells § 146.85 Financial responsibility. (a) The owner or operator must demonstrate...

  9. 40 CFR 146.69 - Reporting requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 23 2011-07-01 2011-07-01 false Reporting requirements. 146.69 Section 146.69 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED... Hazardous Waste Injection Wells § 146.69 Reporting requirements. Reporting requirements shall, at a...

  10. 40 CFR 146.51 - Applicability.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 23 2011-07-01 2011-07-01 false Applicability. 146.51 Section 146.51 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) UNDERGROUND... Wells § 146.51 Applicability. This subpart sets forth criteria and standards for underground...

  11. 40 CFR 146.67 - Operating requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 23 2011-07-01 2011-07-01 false Operating requirements. 146.67 Section 146.67 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED... Hazardous Waste Injection Wells § 146.67 Operating requirements. (a) Except during stimulation, the owner...

  12. 40 CFR 146.32 - Construction requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 23 2011-07-01 2011-07-01 false Construction requirements. 146.32 Section 146.32 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS... to Class III Wells § 146.32 Construction requirements. (a) All new Class III wells shall be cased...

  13. 40 CFR 146.61 - Applicability

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 22 2010-07-01 2010-07-01 false Applicability 146.61 Section 146.61 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) UNDERGROUND... Waste Injection Wells § 146.61 Applicability (a) This subpart establishes criteria and standards...

  14. 40 CFR 146.61 - Applicability

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 23 2011-07-01 2011-07-01 false Applicability 146.61 Section 146.61 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) UNDERGROUND... Waste Injection Wells § 146.61 Applicability (a) This subpart establishes criteria and standards...

  15. 40 CFR 146.65 - Construction requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 23 2011-07-01 2011-07-01 false Construction requirements. 146.65 Section 146.65 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS... to Class I Hazardous Waste Injection Wells § 146.65 Construction requirements. (a) General....

  16. 40 CFR 146.91 - Reporting requirements.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 23 2011-07-01 2011-07-01 false Reporting requirements. 146.91 Section 146.91 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED... Wells § 146.91 Reporting requirements. The owner or operator must, at a minimum, provide, as...

  17. 40 CFR 146.51 - Applicability.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 22 2010-07-01 2010-07-01 false Applicability. 146.51 Section 146.51 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) UNDERGROUND... Wells § 146.51 Applicability. This subpart sets forth criteria and standards for underground...

  18. 40 CFR 146.67 - Operating requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 22 2010-07-01 2010-07-01 false Operating requirements. 146.67 Section 146.67 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED... Hazardous Waste Injection Wells § 146.67 Operating requirements. (a) Except during stimulation, the owner...

  19. 40 CFR 146.89 - Mechanical integrity.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 23 2011-07-01 2011-07-01 false Mechanical integrity. 146.89 Section 146.89 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED... Wells § 146.89 Mechanical integrity. (a) A Class VI well has mechanical integrity if: (1) There is...

  20. 40 CFR 146.65 - Construction requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 22 2010-07-01 2010-07-01 false Construction requirements. 146.65 Section 146.65 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS... to Class I Hazardous Waste Injection Wells § 146.65 Construction requirements. (a) General....

  1. 40 CFR 146.69 - Reporting requirements.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 22 2010-07-01 2010-07-01 false Reporting requirements. 146.69 Section 146.69 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED... Hazardous Waste Injection Wells § 146.69 Reporting requirements. Reporting requirements shall, at a...

  2. 40 CFR 146.22 - Construction requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 23 2014-07-01 2014-07-01 false Construction requirements. 146.22 Section 146.22 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) UNDERGROUND INJECTION CONTROL PROGRAM: CRITERIA AND STANDARDS Criteria and Standards Applicable to Class II Wells § 146.22...

  3. Neodymium doped hydroxyapatite theranostic nanoplatforms for colon specific drug delivery applications.

    PubMed

    Victor, Sunita Prem; Paul, Willi; Vineeth, V M; Komeri, Remya; Jayabalan, Muthu; Sharma, Chandra P

    2016-09-01

    Theranostic nanoplatforms integrate therapeutic payloads with diagnostic agents, and help monitor therapeutic response. In this regard, stimuli responsive nanoplatforms further favour combinatorial therapeutic approach that can considerably improve efficacy and specificity of treatment. Herein, we present the engineering of a smart theranostic nanoplatform based on neodymium doped hydroxyapatite (HAN). The presence of neodymium endows the HAN nanoplatforms with near-infrared fluorescence capability. These HAN nanoparticles were then subsequently modified with alginic acid (HANA) to confer pH responsiveness to the synthesized nanoplatforms delivering them to the colon after oral administration. These nanoplatforms possessing optimum size, needle shaped morphology and negative zeta potential, are conducive to cellular internalization. On excitation at 410nm they exhibit near infrared emission at 670nm unraveling their theranostic capabilities. Cytotoxic effects systematically assessed using MTT and live dead assays reveal excellent viability. Raman microscopic imaging technique used to visualize uptake in HeLa cells demonstrate increased uptake from 4 to 16h, with growing cluster size and localization in the cytoplasm. Moreover the concomitant presence of alginic acid manifested advantages of augmented loading and pH dependent release profiles of the model drug, 4 acetyl salicylic acid (4ASA). We could thus establish a theranostic system for early tumour detection, targeted tumour therapy and monitoring of colon cancer that can be administered via the oral route.

  4. p21 participates in the regulation of anaplastic thyroid cancer cell proliferation by miR-146b

    PubMed Central

    Wang, Shiyang; Chen, Yangjing; Bai, Yanxia

    2016-01-01

    Anaplastic thyroid carcinoma (ATC) originates from completely undifferentiated cells, and is the most lethal type of thyroid-derived tumor. Numerous microRNAs have significant roles in tumorigenesis by targeting relevant genes. The role of microRNA 146b (miR-146b) in ATC remains to be elucidated. In order to characterize the role of miR-146b in ATC, overexpression or interference of miR-146b was induced in ATC cell lines, and cell proliferation and migration were evaluated. The potential targets of miR-146b were searched in the Gene Expression Omnibus database for ATC and matched non-tumor control samples. The expression level of potential targets was detected following overexpression or interference of miR-146b in ATC cell lines. In the present study, cell proliferation was promoted when overexpression of miR-146b was induced in ATC, and inhibited when interference of miR-146b was induced, which indicated that miR-146b affects the proliferation of ATC cells in vitro. In addition, cell migration of ATC was also affected by miR-146b. During the search for potential targets of miR-146b in ATC, p21 (also known as p21Waf1/Cip1 or CDKN1A) was noted for its role in cell cycle progression and tumor pathogenesis. The expression level of p21 was influenced by the level of miR-146b, and the results of the present study demonstrated that the level of p21 was increased when FRO cells were transformed with miR-146b mimic, and p21 was downregulated when FRO cells transformed with anti-miR-146b. In conclusion, p21 may participate in the regulation of ATC cell proliferation by miR-146b. PMID:27602131

  5. Materials flow analysis of neodymium, status of rare earth metal in the Republic of Korea.

    PubMed

    Swain, Basudev; Kang, Leeseung; Mishra, Chinmayee; Ahn, JoongWoo; Hong, Hyun Seon

    2015-11-01

    Materials flow analysis of neodymium, status of rare earth elements (REEs) in the Republic of Korea has been investigated. Information from various resources like the Korean Ministry of Environment, Korea international trade association, United Nations Commodity Trade Statistics Database and from individual industry were collected and analyzed for materials flow analysis of neodymium. Demand of neodymium in the Republic of Korea for the year 2010 was 409.5 tons out of which the majority of neodymium, i.e., 68.41% was consumed by domestic electronics industry followed by medical appliances manufacturing (13.36%). The Republic Korea is one of the biggest consumer and leading exporter of these industrial products, absolutely depends on import of neodymium, as the country is lacking natural resources. The Republic of Korea has imported 325.9 tons of neodymium permanent magnet and 79.5 tons of neodymium containing equipment parts mainly for electronics, medical appliances, and heavy/light vehicles manufacturing industry. Out of which 95.4 tons of neodymium permanent magnet get exported as an intermediate product and 140.6 tons of neodymium in the form of consumable products get exported. Worldwide the neodymium is at the high end of supply chain critical metal because of increasing demand, scarcity and irreplaceable for technological application. To bring back the neodymium to supply stream the recycling of end of life neodymium-bearing waste can be a feasible option. Out of total domestic consumption, only 21.9 tons of neodymium have been collected and subsequently recycled. From material flow analysis, the requirement for an efficient recycling system and element-wise material flow management for these REEs in the Republic of Korea were realized and recommended.

  6. Soluble form of the endothelial adhesion molecule CD146 binds preferentially CD16+ monocytes.

    PubMed

    Garibaldi, Silvano; Barisione, Chiara; Ghigliotti, Giorgio; Spallarossa, Paolo; Barsotti, Antonio; Fabbi, Patrizia; Corsiglia, Luca; Palmieri, Daniela; Palombo, Domenico; Brunelli, Claudio

    2012-06-01

    The cell adhesion molecule CD146 is normally located at the endothelial cell-to-cell junction and colocalizes with actin cytoskeleton. The soluble form of CD146 (sCD146) has been identified in the endothelial cell supernatant and in normal human plasma, and is increased in pathologic conditions with altered endothelial function. Soluble CD146 binding to monocytes promotes their transendothelial migration, which represents a central step in the development of atherosclerotic plaque. Since peripheral blood monocytes are characterized by a phenotypic and functional heterogeneity, with different transendothelial migration capacity, we hypothesized that monocyte subsets differently bind sCD146. Based on surface CD14 and CD16 expression monocytes were distinguished by flow cytometry (FACS) into three subsets: CD14++/CD16-, CD14++/CD16+ and CD14+/CD16+. CD16+ monocytes have been found to possess higher transendothelial migration ability. FACS analysis on blood monocytes from 30 healthy subjects revealed that higher percentages of CD14++/CD16+ (median, first and third quartile: 2.26, 1.62-3.87) and of CD14+/CD16+ (2.59, 1.28-4.80) were positive for CD146 (both p < 0.01), in comparison to CD14++/CD16- (0.66, 0.47-1.01). Moreover, in vitro treatment of ficoll separated monocytes with recombinant CD146 showed that both CD16+ subsets increased their percentage of CD146-positive events compared to CD16- monocytes (p < 0.01). Soluble CD146 levels were evaluated by ELISA in plasma samples of subjects from our study group and showed a correlation with percentage of CD146-positive CD14+/CD16+ monocyte subset. In this work we have demonstrated that monocyte subsets behave differently with regard to their sCD146 binding activity; because binding of CD146 influences transendothelial migration of monocytes, modulation of monocyte-CD146 interaction may represent a potential target to limit atherosclerotic plaque development.

  7. microRNA-146a promotes mycobacterial survival in macrophages through suppressing nitric oxide production.

    PubMed

    Li, Miao; Wang, Jinli; Fang, Yimin; Gong, Sitang; Li, Meiyu; Wu, Minhao; Lai, Xiaomin; Zeng, Gucheng; Wang, Yi; Yang, Kun; Huang, Xi

    2016-03-30

    Macrophages play a crucial role in host innate anti-mycobacterial defense, which is tightly regulated by multiple factors, including microRNAs. Our previous study showed that a panel of microRNAs was markedly up-regulated in macrophages upon mycobacterial infection. Here, we investigated the biological function of miR-146a during mycobacterial infection. miR-146a expression was induced both in vitro and in vivo after Mycobacterium bovis BCG infection. The inducible miR-146a could suppress the inducible nitric oxide (NO) synthase (iNOS) expression and NO generation, thus promoting mycobacterial survival in macrophages. Inhibition of endogenous miR-146a increased NO production and mycobacterial clearance. Moreover, miR-146a attenuated the activation of nuclear factor κB and mitogen-activated protein kinases signaling pathways during BCG infection, which in turn repressed iNOS expression. Mechanistically, miR-146a directly targeted tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6) at post-transcriptional level. Silencing TRAF6 decreased iNOS expression and NO production in BCG-infected macrophages, while overexpression of TRAF6 reversed miR-146a-mediated inhibition of NO production and clearance of mycobacteria. Therefore, we demonstrated a novel role of miR-146a in the modulation of host defense against mycobacterial infection by repressing NO production via targeting TRAF6, which may provide a promising therapeutic target for tuberculosis.

  8. Dissociation of cerium(III) and neodymium(III) phthalocyanines

    NASA Astrophysics Data System (ADS)

    Lomova, T. N.

    2015-07-01

    The kinetics of dissociation of phthalocyanine complexes with cerium(III) and neodymium(III) (X)LnPc (X = Cl-, Br-, AcO-) under the action of acetic acid in ethanol with isolation of the macrocyclic ligand depending on the temperature was studied. The kinetic equations with the numerical values of rate constants, activation parameters, and the stoichiometric mechanisms with the limiting simple reaction between the nonionized AcOH molecule and (phthalocyaninato)lanthanide(III) in the axially coordinated ((X)LnPc, cerium complexes) or axially ionized ([(AcOH)LnPc]+X-, neodymium complexes) state were derived by solving the direct and inverse problems. As shown by a comparative analysis of quantitative kinetic data, the state is determined by the electronic structure of the metal cation and the mutual effect of the axial and equatorial ligands in the first coordination sphere.

  9. Neodymium-YAG laser vitreolysis in sickle cell retinopathy

    SciTech Connect

    Hrisomalos, N.F.; Jampol, L.M.; Moriarty, B.J.; Serjeant, G.; Acheson, R.; Goldberg, M.F.

    1987-08-01

    Six patients with proliferative sickle cell retinopathy and vitreous bands were treated with the neodymium-YAG (Nd-YAG) laser to accomplish lysis of avascular traction bands or to clear the media in front of the macula. Transection of bands was possible in five of the six cases but in two of these the effect was only partial. Three cases were satisfactorily treated with the Nd-YAG laser application alone, two eventually required conventional vitreoretinal surgery, and one patient's condition stabilized despite failure of the treatment. Complications from the treatment occurred in three cases and included subretinal (choroidal) hemorrhage, preretinal hemorrhage, microperforation of a retinal vein, and focal areas of damage to the retinal pigment epithelium. Neodymium-YAG vitreolysis may be a useful modality in carefully selected patients with proliferative sickle cell retinopathy, but potentially sight-threatening complications may occur.

  10. Comment on "Neodymium-142 evidence for Hadean mafic crust".

    PubMed

    Andreasen, Rasmus; Sharma, Mukul

    2009-07-17

    O'Neil et al. (Reports, 26 September 2008, p. 1828) presented neodymium-142 data for rocks from northern Quebec, Canada, and suggested that these rocks may represent the oldest preserved crustal section on Earth. We argue that the age of the rocks is based on a spurious correlation between rocks that are probably not co-genetic and negative (142)Nd anomalies that may be the result of an analytical artifact.

  11. [Neodymium magnet injury causing nasal fracture: a case report].

    PubMed

    Aykan, Andaç; Güzey, Serbülent; Avşar, Sedat; Öztürk, Serdar

    2015-05-01

    In parallel with technological developments, small size but strong magnets are commonly used in modern devices. In terms of foreign body injuries, magnet injuries are quite rare. However, due to their unique characteristics, there are some difficulties in their management. The magnetic field generated by the magnet affects the surgical instruments and make treatment difficult. In this case report, a nasal injury due to neodymium magnet and our alternative approach for its management was reported.

  12. Complexation of di-amides of dipicolinic acid with neodymium

    SciTech Connect

    Lapka, J.L.; Paulenova, A.

    2013-07-01

    Di-amides have undergone significant studies as possible ligands for use in the partitioning of trivalent minor actinides and lanthanides. The binding affinities of three isomeric ligands with neodymium in acetonitrile solution have been investigated. The stability constants of the metal-ligand complexes formed between different isomers of N,N'-diethyl-N,N'- ditolyl-di-picolinamide (EtTDPA) and trivalent neodymium in acetonitrile have been determined by spectrophotometric and calorimetric methods. Each isomer of EtTDPA has been found to be capable of forming three complexes with trivalent neodymium, Nd(EtTDPA), Nd(EtTDPA){sub 2}, and Nd(EtTDPA){sub 3}. Values from spectrophotometric and calorimetric titrations are within reasonable agreement with each other. The order of stability constants for each metal:ligand complex decreases in the order Et(m)TDPA > Et(p)TDPA > Et(o)TDPA. The obtained values are comparable to other di-amidic ligands obtained under similar system conditions and mirror previously obtained solvent extraction data for EtTDPA at low ionic strengths. (authors.

  13. MicroRNA-146a Mimics Reduce the Peripheral Neuropathy in Type II Diabetic Mice.

    PubMed

    Liu, Xian Shuang; Fan, Baoyan; Szalad, Alexandra; Jia, Longfei; Wang, Lei; Wang, Xinli; Pan, Wanlong; Zhang, Li; Zhang, Ruilan; Hu, Jiani; Zhang, Xiao Ming; Chopp, Michael; Zhang, Zheng Gang

    2017-09-12

    MicroRNA-146a (miR-146a) regulates multiple immune diseases. However, the role of miR-146a in diabetic peripheral neuropathy (DPN) has not been investigated. We found that mice (db/db) with type II diabetes exhibited substantial down-regulation of miR-146a in sciatic nerve tissue. Systemic administration of miR-146a mimics to diabetic mice elevated miR-146a levels in plasma and sciatic nerve tissue and substantially increased motor and sensory nerve conduction velocities by 29% and 11%, respectively, and regional blood flow by 50% in sciatic nerve tissue. Treatment with miR-146a mimics also considerably decreased the response in db/db mice to thermal stimuli thresholds. Histopathological analysis showed that miR-146a mimics markedly augmented the density of FITC-dextran perfused blood vessels and increased the number of intraepidermal nerve fibers (IENF), myelin thickness and axonal diameters of sciatic nerves. In addition, miR-146a treatment reduced and increased M1 and M2 macrophage phenotype markers, respectively. Analysis of miRNA target array revealed that miR-146a mimics greatly suppressed expression of many proinflammatory genes and downstream related cytokines. Collectively, our data indicate that treatment of diabetic mice with miR-146a mimics robustly reduces DPN and that suppression of hyperglycemia-induced proinflammatory genes by miR-146a mimics may underlie its therapeutic effect. © 2017 by the American Diabetes Association.

  14. MicroRNA-146b promotes adipogenesis by suppressing the SIRT1-FOXO1 cascade

    PubMed Central

    Ahn, Jiyun; Lee, Hyunjung; Jung, Chang Hwa; Jeon, Tae Il; Ha, Tae Youl

    2013-01-01

    Sirtuin 1 (SIRT1) plays a critical role in the maintenance of metabolic homeostasis and promotes fat mobilization in white adipose tissue. However, regulation of SIRT1 during adipogenesis, particularly through microRNAs, remains unclear. We observed that miR-146b expression was markedly increased during adipogenesis in 3T3-L1 cells. Differentiation of 3T3-L1 was induced by overexpression of miR-146b. Conversely, inhibition of miR-146b decreased adipocyte differentiation. Bioinformatics-based studies suggested that SIRT1 is a target of miR-146b. Further analysis confirmed that SIRT1 was negatively regulated by miR-146b. We also observed that miR-146b bound directly to the 3′-untranslated region of SIRT1 and inhibited adipogenesis through SIRT1 downregulation. The miR-146b/SIRT1 axis mediates adipogenesis through increased acetylation of forkhead box O1 (FOXO1). Expression of miR-146b was increased and SIRT1 mRNA subsequently decreased in the adipose tissues of diet-induced and genetically obese mice. Furthermore, in vivo knockdown of miR-146b by a locked nucleic acid miR-146b antagomir significantly reduced body weight and fat volume in accordance with upregulation of SIRT1 and subsequent acetylation of FOXO1. Therefore, the miR-146b/SIRT1 pathway could be a potential target for obesity prevention and treatment. PMID:24009212

  15. MicroRNA-146a Contributes to SCI Recovery via Regulating TRAF6 and IRAK1 Expression

    PubMed Central

    Wei, Jinsong; Zhou, Yulan; Yan, Shouquan

    2016-01-01

    MicroRNA-146a participates in spinal cord injury (SCI) recovery. Until recently, how miRNA-146a participates in SCI remained unclear. In this study, we tried to explore the roles of miRNA-146a in the recovery of SCI using a rat model. The expression of the probable target genes of miRNA-146a (including IRAK1 and TARF6) as well as proinflammation cytokines were measured until 7 days after surgery in the three groups (sham group, SCI group, and miRNA-146a antagomir injection group). Also, the animals' motivations were estimated using Basso Beattie Bresnahan (BBB) during the whole experiment. A luciferase assay was performed to demonstrate that miRNA-146a could directly target the mRNAs of IRAK1 and TRAF6. Our experiments indicate that miRNA-146a inhibits proinflammatory cytokine secretion by suppressing IRAK1 and TRAF6 expression in the SCI model. In contrast, miRNA-146a may be upregulated by inflammatory mediators via the IRAK1/TRAF6 pathway in the spinal cord. As a negative feedback element, miRNA-146a could make sure that the expression of IRAK1- and TRAF6-mediated genes was under tight control. Thus, miRNA-146a may serve as a novel therapeutic target for SCI interventions. PMID:27830143

  16. MicroRNA-146a modulates B-cell oncogenesis by regulating Egr1

    PubMed Central

    Contreras, Jorge R.; Palanichamy, Jayanth Kumar; Tran, Tiffany M.; Fernando, Thilini R.; Rodriguez-Malave, Norma I.; Goswami, Neha; Arboleda, Valerie A.; Casero, David; Rao, Dinesh S.

    2015-01-01

    miR-146a is a NF-κB induced microRNA that serves as a feedback regulator of this critical pathway. In mice, deficiency of miR-146a results in hematolymphoid cancer at advanced ages as a consequence of constitutive NF-κB activity. In this study, we queried whether the deficiency of miR-146a contributes to B-cell oncogenesis. Combining miR-146a deficiency with transgenic expression of c-Myc led to the development of highly aggressive B-cell malignancies. Mice transgenic for c-Myc and deficient for miR-146a were characterized by significantly shortened survival, increased lymph node involvement, differential involvement of the spleen and a mature B-cell phenotype. High-throughput sequencing of the tumors revealed significant dysregulation of approximately 250 genes. Amongst these, the transcription factor Egr1 was consistently upregulated in mice deficient for miR-146a. Interestingly, transcriptional targets of Egr1 were enriched in both the high-throughput dataset and in a larger set of miR-146a-deficient tumors. miR-146a overexpression led to downregulation of Egr1 and downstream targets with concomitant decrease in cell growth. Direct targeting of the human EGR1 by miR-146a was seen by luciferase assay. Together our findings illuminate a bona fide role for miR-146a in the modulation of B-cell oncogenesis and reveal the importance of understanding microRNA function in a cell- and disease-specific context. PMID:25906746

  17. MicroRNA-146a modulates B-cell oncogenesis by regulating Egr1.

    PubMed

    Contreras, Jorge R; Palanichamy, Jayanth Kumar; Tran, Tiffany M; Fernando, Thilini R; Rodriguez-Malave, Norma I; Goswami, Neha; Arboleda, Valerie A; Casero, David; Rao, Dinesh S

    2015-05-10

    miR-146a is a NF-κB induced microRNA that serves as a feedback regulator of this critical pathway. In mice, deficiency of miR-146a results in hematolymphoid cancer at advanced ages as a consequence of constitutive NF-κB activity. In this study, we queried whether the deficiency of miR-146a contributes to B-cell oncogenesis. Combining miR-146a deficiency with transgenic expression of c-Myc led to the development of highly aggressive B-cell malignancies. Mice transgenic for c-Myc and deficient for miR-146a were characterized by significantly shortened survival, increased lymph node involvement, differential involvement of the spleen and a mature B-cell phenotype. High-throughput sequencing of the tumors revealed significant dysregulation of approximately 250 genes. Amongst these, the transcription factor Egr1 was consistently upregulated in mice deficient for miR-146a. Interestingly, transcriptional targets of Egr1 were enriched in both the high-throughput dataset and in a larger set of miR-146a-deficient tumors. miR-146a overexpression led to downregulation of Egr1 and downstream targets with concomitant decrease in cell growth. Direct targeting of the human EGR1 by miR-146a was seen by luciferase assay. Together our findings illuminate a bona fide role for miR-146a in the modulation of B-cell oncogenesis and reveal the importance of understanding microRNA function in a cell- and disease-specific context.

  18. 33 CFR 146.45 - Pollution incidents.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Pollution incidents. 146.45...) OUTER CONTINENTAL SHELF ACTIVITIES OPERATIONS OCS Facilities § 146.45 Pollution incidents. Oil pollution.... Additional provisions concerning liability and compensation because of oil pollution are contained in...

  19. 33 CFR 146.45 - Pollution incidents.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Pollution incidents. 146.45...) OUTER CONTINENTAL SHELF ACTIVITIES OPERATIONS OCS Facilities § 146.45 Pollution incidents. Oil pollution.... Additional provisions concerning liability and compensation because of oil pollution are contained in...

  20. 33 CFR 146.45 - Pollution incidents.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Pollution incidents. 146.45...) OUTER CONTINENTAL SHELF ACTIVITIES OPERATIONS OCS Facilities § 146.45 Pollution incidents. Oil pollution.... Additional provisions concerning liability and compensation because of oil pollution are contained in...

  1. 33 CFR 146.45 - Pollution incidents.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Pollution incidents. 146.45...) OUTER CONTINENTAL SHELF ACTIVITIES OPERATIONS OCS Facilities § 146.45 Pollution incidents. Oil pollution.... Additional provisions concerning liability and compensation because of oil pollution are contained in...

  2. 9 CFR 146.10 - Supervision.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Supervision. 146.10 Section 146.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... authorize qualified persons as State Inspectors to perform the selecting and testing of participating flocks...

  3. 9 CFR 146.10 - Supervision.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Supervision. 146.10 Section 146.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... authorize qualified persons as State Inspectors to perform the selecting and testing of participating flocks...

  4. 21 CFR 146.135 - Orange juice.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 2 2012-04-01 2012-04-01 false Orange juice. 146.135 Section 146.135 Food and....135 Orange juice. (a) Orange juice is the unfermented juice obtained from mature oranges of the... name of the food is “orange juice”. The name “orange juice” may be preceded on the label by...

  5. 21 CFR 146.135 - Orange juice.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Orange juice. 146.135 Section 146.135 Food and....135 Orange juice. (a) Orange juice is the unfermented juice obtained from mature oranges of the... name of the food is “orange juice”. The name “orange juice” may be preceded on the label by...

  6. 21 CFR 146.135 - Orange juice.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Orange juice. 146.135 Section 146.135 Food and....135 Orange juice. (a) Orange juice is the unfermented juice obtained from mature oranges of the... name of the food is “orange juice”. The name “orange juice” may be preceded on the label by...

  7. 21 CFR 146.135 - Orange juice.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 2 2014-04-01 2014-04-01 false Orange juice. 146.135 Section 146.135 Food and....135 Orange juice. (a) Orange juice is the unfermented juice obtained from mature oranges of the... name of the food is “orange juice”. The name “orange juice” may be preceded on the label by...

  8. 21 CFR 146.135 - Orange juice.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 2 2013-04-01 2013-04-01 false Orange juice. 146.135 Section 146.135 Food and....135 Orange juice. (a) Orange juice is the unfermented juice obtained from mature oranges of the... name of the food is “orange juice”. The name “orange juice” may be preceded on the label by...

  9. 10 CFR 72.146 - Design control.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Design control. 72.146 Section 72.146 Energy NUCLEAR... Design control. (a) The licensee, applicant for a license, certificate holder, and applicant for a CoC... shall establish measures for the identification and control of design interfaces and for...

  10. 33 CFR 146.45 - Pollution incidents.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Pollution incidents. 146.45...) OUTER CONTINENTAL SHELF ACTIVITIES OPERATIONS OCS Facilities § 146.45 Pollution incidents. Oil pollution.... Additional provisions concerning liability and compensation because of oil pollution are contained in...

  11. 9 CFR 146.10 - Supervision.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Supervision. 146.10 Section 146.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... authorize qualified persons as State Inspectors to perform the selecting and testing of participating flocks...

  12. 9 CFR 146.10 - Supervision.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Supervision. 146.10 Section 146.10 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... authorize qualified persons as State Inspectors to perform the selecting and testing of participating flocks...

  13. 9 CFR 146.2 - Administration.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Administration. 146.2 Section 146.2... Administration. (a) The Department cooperates through a Memorandum of Understanding with the Official State Agency in the administration of the Plan. In the Memorandum of Understanding, the Official State Agency...

  14. 19 CFR 146.1 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false Definitions. 146.1 Section 146.1 Customs Duties U.... “Default” means an action or omission that will result in a claim for duties, taxes, charges, or liquidated... prohibited by law on grounds of public policy or morals, or any merchandise which is excluded from a zone by...

  15. 19 CFR 146.1 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Definitions. 146.1 Section 146.1 Customs Duties U.... “Default” means an action or omission that will result in a claim for duties, taxes, charges, or liquidated... prohibited by law on grounds of public policy or morals, or any merchandise which is excluded from a zone by...

  16. 33 CFR 146.125 - Emergency drills.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Emergency drills. 146.125 Section... CONTINENTAL SHELF ACTIVITIES OPERATIONS Manned OCS Facilities § 146.125 Emergency drills. (a) Emergency drills shall be conducted at least once each month by the person in charge of the manned facility. The drill...

  17. 33 CFR 146.125 - Emergency drills.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Emergency drills. 146.125 Section... CONTINENTAL SHELF ACTIVITIES OPERATIONS Manned OCS Facilities § 146.125 Emergency drills. (a) Emergency drills shall be conducted at least once each month by the person in charge of the manned facility. The drill...

  18. 33 CFR 146.125 - Emergency drills.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Emergency drills. 146.125 Section... CONTINENTAL SHELF ACTIVITIES OPERATIONS Manned OCS Facilities § 146.125 Emergency drills. (a) Emergency drills shall be conducted at least once each month by the person in charge of the manned facility. The drill...

  19. 33 CFR 146.125 - Emergency drills.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Emergency drills. 146.125 Section... CONTINENTAL SHELF ACTIVITIES OPERATIONS Manned OCS Facilities § 146.125 Emergency drills. (a) Emergency drills shall be conducted at least once each month by the person in charge of the manned facility. The drill...

  20. 21 CFR 146.114 - Lemon juice.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 2 2014-04-01 2014-04-01 false Lemon juice. 146.114 Section 146.114 Food and....114 Lemon juice. (a) Identity—(1) Description. Lemon juice is the unfermented juice, obtained by mechanical process, from sound, mature lemons (Citrus limon (L.) Burm. f.), from which seeds (except...

  1. 9 CFR 146.3 - Participation.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Participation. 146.3 Section 146.3... Participation. (a) Any table-egg producer, raised-for-release upland game bird premises, and raised-for-release...) Participation in the Plan shall entitle the participant to use the Plan emblem reproduced as follows:...

  2. 22 CFR 146.525 - Fringe benefits.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Employment in Education Programs or Activities Prohibited § 146.525 Fringe benefits. (a) “Fringe benefits... Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION..., leave, and any other benefit or service of employment not subject to the provision of § 146.515....

  3. 9 CFR 146.11 - Inspections.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Inspections. 146.11 Section 146.11 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... Inspections. (a) Each participating slaughter plant shall be audited at least once annually or a...

  4. 17 CFR 146.12 - Exemptions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... effectiveness and orderly conduct of the Commission's regulatory and enforcement program. Materials exempted... 17 Commodity and Securities Exchanges 1 2012-04-01 2012-04-01 false Exemptions. 146.12 Section 146.12 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION RECORDS MAINTAINED ON...

  5. 17 CFR 146.12 - Exemptions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... effectiveness and orderly conduct of the Commission's regulatory and enforcement program. Materials exempted... 17 Commodity and Securities Exchanges 1 2011-04-01 2011-04-01 false Exemptions. 146.12 Section 146.12 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION RECORDS MAINTAINED ON...

  6. 40 CFR 146.89 - Mechanical integrity.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 24 2012-07-01 2012-07-01 false Mechanical integrity. 146.89 Section... Wells § 146.89 Mechanical integrity. (a) A Class VI well has mechanical integrity if: (1) There is no... may require any other test to evaluate mechanical integrity under paragraphs (a)(1) or (a)(2) of this...

  7. 40 CFR 146.8 - Mechanical integrity.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 24 2012-07-01 2012-07-01 false Mechanical integrity. 146.8 Section...) UNDERGROUND INJECTION CONTROL PROGRAM: CRITERIA AND STANDARDS General Provisions § 146.8 Mechanical integrity. (a) An injection well has mechanical integrity if: (1) There is no significant leak in the casing...

  8. 40 CFR 146.89 - Mechanical integrity.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 23 2014-07-01 2014-07-01 false Mechanical integrity. 146.89 Section... Wells § 146.89 Mechanical integrity. (a) A Class VI well has mechanical integrity if: (1) There is no... may require any other test to evaluate mechanical integrity under paragraphs (a)(1) or (a)(2) of this...

  9. 40 CFR 146.8 - Mechanical integrity.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 23 2014-07-01 2014-07-01 false Mechanical integrity. 146.8 Section...) UNDERGROUND INJECTION CONTROL PROGRAM: CRITERIA AND STANDARDS General Provisions § 146.8 Mechanical integrity. (a) An injection well has mechanical integrity if: (1) There is no significant leak in the casing...

  10. 40 CFR 146.89 - Mechanical integrity.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 24 2013-07-01 2013-07-01 false Mechanical integrity. 146.89 Section... Wells § 146.89 Mechanical integrity. (a) A Class VI well has mechanical integrity if: (1) There is no... may require any other test to evaluate mechanical integrity under paragraphs (a)(1) or (a)(2) of this...

  11. 33 CFR 146.110 - Emergency signals.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Emergency signals. 146.110...) OUTER CONTINENTAL SHELF ACTIVITIES OPERATIONS Manned OCS Facilities § 146.110 Emergency signals. (a) The owner, the owner's agent, or the person in charge shall establish emergency signals to be used for...

  12. 33 CFR 146.110 - Emergency signals.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Emergency signals. 146.110...) OUTER CONTINENTAL SHELF ACTIVITIES OPERATIONS Manned OCS Facilities § 146.110 Emergency signals. (a) The owner, the owner's agent, or the person in charge shall establish emergency signals to be used for...

  13. 33 CFR 146.110 - Emergency signals.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Emergency signals. 146.110...) OUTER CONTINENTAL SHELF ACTIVITIES OPERATIONS Manned OCS Facilities § 146.110 Emergency signals. (a) The owner, the owner's agent, or the person in charge shall establish emergency signals to be used for...

  14. 33 CFR 146.110 - Emergency signals.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Emergency signals. 146.110...) OUTER CONTINENTAL SHELF ACTIVITIES OPERATIONS Manned OCS Facilities § 146.110 Emergency signals. (a) The owner, the owner's agent, or the person in charge shall establish emergency signals to be used for...

  15. 33 CFR 146.110 - Emergency signals.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Emergency signals. 146.110...) OUTER CONTINENTAL SHELF ACTIVITIES OPERATIONS Manned OCS Facilities § 146.110 Emergency signals. (a) The owner, the owner's agent, or the person in charge shall establish emergency signals to be used for...

  16. 22 CFR 146.220 - Admissions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... vocational education, professional education, graduate higher education, and public institutions of undergraduate higher education. (e) Public institutions of undergraduate higher education. §§ 146.300 through 146.310 do not apply to any public institution of undergraduate higher education that...

  17. 22 CFR 146.220 - Admissions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... vocational education, professional education, graduate higher education, and public institutions of undergraduate higher education. (e) Public institutions of undergraduate higher education. §§ 146.300 through 146.310 do not apply to any public institution of undergraduate higher education that...

  18. 22 CFR 146.220 - Admissions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... vocational education, professional education, graduate higher education, and public institutions of undergraduate higher education. (e) Public institutions of undergraduate higher education. §§ 146.300 through 146.310 do not apply to any public institution of undergraduate higher education that...

  19. 22 CFR 146.220 - Admissions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... vocational education, professional education, graduate higher education, and public institutions of undergraduate higher education. (e) Public institutions of undergraduate higher education. §§ 146.300 through 146.310 do not apply to any public institution of undergraduate higher education that...

  20. 22 CFR 146.220 - Admissions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... vocational education, professional education, graduate higher education, and public institutions of undergraduate higher education. (e) Public institutions of undergraduate higher education. §§ 146.300 through 146.310 do not apply to any public institution of undergraduate higher education that...

  1. 9 CFR 146.2 - Administration.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Administration. 146.2 Section 146.2 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE... of the Plan in such State further defining the provisions of the Plan or establishing...

  2. 27 CFR 9.146 - Lake Wisconsin.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Lake Wisconsin. 9.146... OF THE TREASURY LIQUORS AMERICAN VITICULTURAL AREAS Approved American Viticultural Areas § 9.146 Lake Wisconsin. (a) Name. The name of the viticultural area described in this section is “Lake Wisconsin.” (b...

  3. 27 CFR 9.146 - Lake Wisconsin.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2014-04-01 2014-04-01 false Lake Wisconsin. 9.146... OF THE TREASURY ALCOHOL AMERICAN VITICULTURAL AREAS Approved American Viticultural Areas § 9.146 Lake Wisconsin. (a) Name. The name of the viticultural area described in this section is “Lake Wisconsin.” (b...

  4. 27 CFR 9.146 - Lake Wisconsin.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Lake Wisconsin. 9.146... OF THE TREASURY LIQUORS AMERICAN VITICULTURAL AREAS Approved American Viticultural Areas § 9.146 Lake Wisconsin. (a) Name. The name of the viticultural area described in this section is “Lake Wisconsin.” (b...

  5. 27 CFR 9.146 - Lake Wisconsin.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2013-04-01 2013-04-01 false Lake Wisconsin. 9.146... OF THE TREASURY ALCOHOL AMERICAN VITICULTURAL AREAS Approved American Viticultural Areas § 9.146 Lake Wisconsin. (a) Name. The name of the viticultural area described in this section is “Lake Wisconsin.” (b...

  6. 21 CFR 146.114 - Lemon juice.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Lemon juice. 146.114 Section 146.114 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN... food. The lemon oil and lemon essence (derived from lemons) content may be adjusted in accordance with...

  7. 21 CFR 146.132 - Grapefruit juice.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Grapefruit juice. 146.132 Section 146.132 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN... in the finished food. The grapefruit pulp, grapefruit oil, and grapefuit essence (components derived...

  8. 21 CFR 146.185 - Pineapple juice.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Pineapple juice. 146.185 Section 146.185 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN... such that the total vitamin C in each 4 fluid ounces of the finished food amounts to not less than 30...

  9. 21 CFR 146.132 - Grapefruit juice.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 2 2013-04-01 2013-04-01 false Grapefruit juice. 146.132 Section 146.132 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN... in the finished food. The grapefruit pulp, grapefruit oil, and grapefuit essence (components derived...

  10. 21 CFR 146.114 - Lemon juice.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 2 2013-04-01 2013-04-01 false Lemon juice. 146.114 Section 146.114 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN... food. The lemon oil and lemon essence (derived from lemons) content may be adjusted in accordance with...

  11. 21 CFR 146.185 - Pineapple juice.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 2 2012-04-01 2012-04-01 false Pineapple juice. 146.185 Section 146.185 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN... such that the total vitamin C in each 4 fluid ounces of the finished food amounts to not less than 30...

  12. 21 CFR 146.185 - Pineapple juice.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Pineapple juice. 146.185 Section 146.185 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN... such that the total vitamin C in each 4 fluid ounces of the finished food amounts to not less than 30...

  13. 21 CFR 146.114 - Lemon juice.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 2 2012-04-01 2012-04-01 false Lemon juice. 146.114 Section 146.114 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN... food. The lemon oil and lemon essence (derived from lemons) content may be adjusted in accordance with...

  14. 21 CFR 146.185 - Pineapple juice.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 2 2013-04-01 2013-04-01 false Pineapple juice. 146.185 Section 146.185 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN... such that the total vitamin C in each 4 fluid ounces of the finished food amounts to not less than 30...

  15. 21 CFR 146.132 - Grapefruit juice.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 2 2012-04-01 2012-04-01 false Grapefruit juice. 146.132 Section 146.132 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN... in the finished food. The grapefruit pulp, grapefruit oil, and grapefuit essence (components derived...

  16. 21 CFR 146.132 - Grapefruit juice.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Grapefruit juice. 146.132 Section 146.132 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN... in the finished food. The grapefruit pulp, grapefruit oil, and grapefuit essence (components derived...

  17. 21 CFR 146.114 - Lemon juice.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Lemon juice. 146.114 Section 146.114 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) FOOD FOR HUMAN... food. The lemon oil and lemon essence (derived from lemons) content may be adjusted in accordance with...

  18. 10 CFR 72.146 - Design control.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 10 Energy 2 2011-01-01 2011-01-01 false Design control. 72.146 Section 72.146 Energy NUCLEAR... Design control. (a) The licensee, applicant for a license, certificate holder, and applicant for a CoC shall establish measures to ensure that applicable regulatory requirements and the design basis,...

  19. 13 CFR 146.405 - Penalty procedures.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Penalty procedures. 146.405 Section 146.405 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION NEW RESTRICTIONS ON LOBBYING... pursuant to the provisions of the Program Fraud and Civil Remedies Act, 31 U.S.C. sections 3803...

  20. 33 CFR 146.125 - Emergency drills.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Emergency drills. 146.125 Section... CONTINENTAL SHELF ACTIVITIES OPERATIONS Manned OCS Facilities § 146.125 Emergency drills. (a) Emergency drills shall be conducted at least once each month by the person in charge of the manned facility. The...

  1. 40 CFR 146.21 - Applicability.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 23 2011-07-01 2011-07-01 false Applicability. 146.21 Section 146.21 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) UNDERGROUND INJECTION CONTROL PROGRAM: CRITERIA AND STANDARDS Criteria and Standards Applicable to Class II Wells §...

  2. 40 CFR 146.31 - Applicability.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 23 2011-07-01 2011-07-01 false Applicability. 146.31 Section 146.31 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) UNDERGROUND INJECTION CONTROL PROGRAM: CRITERIA AND STANDARDS Criteria and Standards Applicable to Class III Wells §...

  3. 40 CFR 146.31 - Applicability.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 22 2010-07-01 2010-07-01 false Applicability. 146.31 Section 146.31 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) UNDERGROUND INJECTION CONTROL PROGRAM: CRITERIA AND STANDARDS Criteria and Standards Applicable to Class III Wells §...

  4. 40 CFR 146.21 - Applicability.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 22 2010-07-01 2010-07-01 false Applicability. 146.21 Section 146.21 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) UNDERGROUND INJECTION CONTROL PROGRAM: CRITERIA AND STANDARDS Criteria and Standards Applicable to Class II Wells §...

  5. 40 CFR 146.8 - Mechanical integrity.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 23 2011-07-01 2011-07-01 false Mechanical integrity. 146.8 Section...) UNDERGROUND INJECTION CONTROL PROGRAM: CRITERIA AND STANDARDS General Provisions § 146.8 Mechanical integrity. (a) An injection well has mechanical integrity if: (1) There is no significant leak in the casing...

  6. CD146(+) cells are essential for kidney vasculature development.

    PubMed

    Halt, Kimmo J; Pärssinen, Heikki E; Junttila, Sanna M; Saarela, Ulla; Sims-Lucas, Sunder; Koivunen, Peppi; Myllyharju, Johanna; Quaggin, Susan; Skovorodkin, Ilya N; Vainio, Seppo J

    2016-08-01

    The kidney vasculature is critical for renal function, but its developmental assembly mechanisms remain poorly understood and models for studying its assembly dynamics are limited. Here, we tested whether the embryonic kidney contains endothelial cells (ECs) that are heterogeneous with respect to VEGFR2/Flk1/KDR, CD31/PECAM, and CD146/MCAM markers. Tie1Cre;R26R(YFP)-based fate mapping with a time-lapse in embryonic kidney organ culture successfully depicted the dynamics of kidney vasculature development and the correlation of the process with the CD31(+) EC network. Depletion of Tie1(+) or CD31(+) ECs from embryonic kidneys, with either Tie1Cre-induced diphtheria toxin susceptibility or cell surface marker-based sorting in a novel dissociation and reaggregation technology, illustrated substantial EC network regeneration. Depletion of the CD146(+) cells abolished this EC regeneration. Fate mapping of green fluorescent protein (GFP)-marked CD146(+)/CD31(-) cells indicated that they became CD31(+) cells, which took part in EC structures with CD31(+) wild-type ECs. EC network development depends on VEGF signaling, and VEGF and erythropoietin are expressed in the embryonic kidney even in the absence of any external hypoxic stimulus. Thus, the ex vivo embryonic kidney culture models adopted here provided novel ways for targeting renal EC development and demonstrated that CD146(+) cells are critical for kidney vasculature development. Copyright © 2016 International Society of Nephrology. All rights reserved.

  7. Identification of soluble CD146 as a regulator of trophoblast migration: potential role in placental vascular development.

    PubMed

    Kaspi, Elise; Guillet, Benjamin; Piercecchi-Marti, Marie-Dominique; Alfaidy, Nadia; Bretelle, Florence; Bertaud-Foucault, Alexandrine; Stalin, Jimmy; Rambeloson, Laka; Lacroix, Odile; Blot-Chabaud, Marcel; Dignat-George, Françoise; Bardin, Nathalie

    2013-04-01

    Both vasculogenesis and angiogenesis occur during normal placental vascular development. Additionally, the placenta undergoes a process of vascular mimicry (pseudo-vasculogenesis) where the placental extravillous trophoblast (EVT) that invade the spiral arteries convert from an epithelial to an endothelial phenotype during normal pregnancy. As soluble CD146 (sCD146) constitutes a new physiological factor with angiogenic properties, we hypothesized that it could be involved in the regulation of placental vascular development by acting on EVT. Using placental villous explants, we demonstrated that sCD146 inhibits EVT outgrowth. Consistently, we showed that sCD146 inhibits the ability of EVT cells (HTR8/SVneo) to migrate, invade and form tubes in Matrigel, without affecting their proliferation or apoptosis. The involvement of sCD146 in human pregnancy was investigated by evaluation of sCD146 levels in 50 pregnant women. We observed physiological down-regulation of sCD146 throughout pregnancy. These results prompted us to investigate the effect of prolonged sCD146 administration in a rat model of pregnancy. Repeated systemic sCD146 injections after coupling caused a significant decrease of pregnancy rate and number of embryos. Histological studies performed on placenta evidenced a reduced migration of glycogen cells (analogous to EVT in rat) in sCD146-treated rats. We propose that in human, sCD146 could represent both an attractive biomarker of placental vascular development and a therapeutic target in pregnancy complications associated with pathological angiogenesis.

  8. Isotope effects of neodymium in different ligands exchange systems studied by ion exchange displacement chromatography

    PubMed Central

    Ismail, Ibrahim; Fawzy, Ahmed S.; Ahmad, Mohammad I.; Aly, Hisham F.; Nomura, Masao; Fujii, Yasuhiko

    2012-01-01

    The isotope effects of neodymium in Nd-glycolate ligand exchange system were studied by using ion exchange chromatography. The separation coefficients of neodymium isotopes, ε’s, were calculated from the observed isotopic ratios at the front and rear boundaries of the neodymium adsorption band. The values of separation coefficients of neodymium isotopes, ε’s, for the Nd-glycolate ligand exchange system were compared with those of Nd-malate and Nd-citrate, which indicated that the isotope effects of neodymium as studied by the three ligands takes the following direction Malate > Citrate > Glycolate. This order agrees with the number of available sites for complexation of each ligand. The values of the plate height, HETP of Nd in Nd-ligand exchange systems were also calculated. PMID:25685410

  9. Isotope effects of neodymium in different ligands exchange systems studied by ion exchange displacement chromatography.

    PubMed

    Ismail, Ibrahim; Fawzy, Ahmed S; Ahmad, Mohammad I; Aly, Hisham F; Nomura, Masao; Fujii, Yasuhiko

    2013-03-01

    The isotope effects of neodymium in Nd-glycolate ligand exchange system were studied by using ion exchange chromatography. The separation coefficients of neodymium isotopes, ε's, were calculated from the observed isotopic ratios at the front and rear boundaries of the neodymium adsorption band. The values of separation coefficients of neodymium isotopes, ε's, for the Nd-glycolate ligand exchange system were compared with those of Nd-malate and Nd-citrate, which indicated that the isotope effects of neodymium as studied by the three ligands takes the following direction Malate > Citrate > Glycolate. This order agrees with the number of available sites for complexation of each ligand. The values of the plate height, HETP of Nd in Nd-ligand exchange systems were also calculated.

  10. Do foraminifera accurately record seawater neodymium isotope composition?

    NASA Astrophysics Data System (ADS)

    Scrivner, Adam; Skinner, Luke; Vance, Derek

    2010-05-01

    Palaeoclimate studies involving the reconstruction of past Atlantic meridional overturning circulation increasingly employ isotopes of neodymium (Nd), measured on a variety of sample media (Frank, 2002). In the open ocean, Nd isotopes are a conservative tracer of water mass mixing and are unaffected by biological and low-temperature fractionation processes (Piepgras and Wasserburg, 1987; Lacan and Jeandel, 2005). For decades, benthic foraminifera have been widely utilised in stable isotope and geochemical studies, but have only recently begun to be exploited as a widely distributed, high-resolution Nd isotope archive (Klevenz et al., 2008), potentially circumventing the difficulties associated with other methods used to recover past deep-water Nd isotopes (Klevenz et al., 2008; Rutberg et al., 2000; Tachikawa et al., 2004). Thus far, a single pilot study (Klevenz et al., 2008) has indicated that core-top sedimentary benthic foraminifera record a Nd isotope composition in agreement with the nearest available bottom seawater data, and has suggested that this archive is potentially useful on both millennial and million-year timescales. Here we present seawater and proximal core-top foraminifer Nd isotope data for samples recovered during the 2008 "RETRO" cruise of the Marion Dufresne. The foraminifer samples comprise a depth-transect spanning 3000m of the water column in the Angola Basin and permit a direct comparison between high-resolution water column and core-top foraminiferal Nd isotope data. We use these data to assess the reliability of both planktonic and benthic foraminifera as recorders of water column neodymium isotope composition. Frank, M., 2002. Radiogenic isotopes: Tracers of past ocean circulation and erosional input, Rev. Geophys., 40 (1), 1001, doi:10.1029/2000RG000094. Klevenz, V., Vance, D., Schmidt, D.N., and Mezger, K., 2008. Neodymium isotopes in benthic foraminifera: Core-top systematics and a down-core record from the Neogene south Atlantic

  11. CD146, an epithelial-mesenchymal transition inducer, is associated with triple-negative breast cancer.

    PubMed

    Zeng, Qiqun; Li, Weidong; Lu, Di; Wu, Zhenzhen; Duan, Hongxia; Luo, Yongting; Feng, Jing; Yang, Dongling; Fu, Li; Yan, Xiyun

    2012-01-24

    The epithelial-mesenchymal transition (EMT) plays an important role in breast cancer metastasis, especially in the most aggressive and lethal subtype, "triple-negative breast cancer" (TNBC). Here, we report that CD146 is a unique activator of EMTs and significantly correlates with TNBC. In epithelial breast cancer cells, overexpression of CD146 down-regulated epithelial markers and up-regulated mesenchymal markers, significantly promoted cell migration and invasion, and induced cancer stem cell-like properties. We further found that RhoA pathways positively regulated CD146-induced EMTs via the key EMT transcriptional factor Slug. An orthotopic breast tumor model demonstrated that CD146-overexpressing breast tumors showed a poorly differentiated phenotype and displayed increased tumor invasion and metastasis. We confirmed these findings by conducting an immunohistochemical analysis of 505 human primary breast tumor tissues and found that CD146 expression was significantly associated with high tumor stage, poor prognosis, and TNBC. CD146 was expressed at abnormally high levels (68.9%), and was strongly associated with E-cadherin down-regulation in TNBC samples. Taken together, these findings provide unique evidence that CD146 promotes breast cancer progression by induction of EMTs via the activation of RhoA and up-regulation of Slug. Thus, CD146 could be a therapeutic target for breast cancer, especially for TNBC.

  12. 21 CFR 146.145 - Orange juice from concentrate.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Orange juice from concentrate. 146.145 Section 146... Juices and Beverages § 146.145 Orange juice from concentrate. (a) Orange juice from concentrate is the food prepared by mixing water with frozen concentrated orange juice as defined in § 146.146 or...

  13. 21 CFR 146.145 - Orange juice from concentrate.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 2 2013-04-01 2013-04-01 false Orange juice from concentrate. 146.145 Section 146... Juices and Beverages § 146.145 Orange juice from concentrate. (a) Orange juice from concentrate is the food prepared by mixing water with frozen concentrated orange juice as defined in § 146.146 or...

  14. 21 CFR 146.145 - Orange juice from concentrate.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Orange juice from concentrate. 146.145 Section 146... Juices and Beverages § 146.145 Orange juice from concentrate. (a) Orange juice from concentrate is the food prepared by mixing water with frozen concentrated orange juice as defined in § 146.146 or...

  15. 21 CFR 146.145 - Orange juice from concentrate.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 2 2014-04-01 2014-04-01 false Orange juice from concentrate. 146.145 Section 146... Juices and Beverages § 146.145 Orange juice from concentrate. (a) Orange juice from concentrate is the food prepared by mixing water with frozen concentrated orange juice as defined in § 146.146 or...

  16. 21 CFR 146.145 - Orange juice from concentrate.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 2 2012-04-01 2012-04-01 false Orange juice from concentrate. 146.145 Section 146... Juices and Beverages § 146.145 Orange juice from concentrate. (a) Orange juice from concentrate is the food prepared by mixing water with frozen concentrated orange juice as defined in § 146.146 or...

  17. Local immunity in treating skin melanoma by neodymium pulsed laser

    NASA Astrophysics Data System (ADS)

    Moskalik, Konstantin G.

    1997-06-01

    The number and correlation of skin stroma cells was studied on mice C57B1 with the subcutaneously transplanted melanoma B16 which was exposed to neodymium pulsed laser radiation. Within 1-5 days after the exposure the total number of the free skin stroma cells was found to increase in the periphery from the radiation epicenter and the number of lymphocytes, macrophages and leucocytes tended to grow. Lymphoid infiltration was also revealed in the preparations of the epithelized wound and cicatrix on the skin melanoma sites in the patients who had undergone pulsed laser radiation therapy.

  18. Pulsed neodymium-YAG laser trabeculotomy: energy requirements and replicability.

    PubMed Central

    Dutton, G N; Allan, D; Cameron, S A

    1989-01-01

    Short pulsed laser trabeculotomy has been shown to reduce intraocular pressure in patients with primary open angle glaucoma. This study seeks to determine the energy levels required to produce a fistula into the canal of Schlemm for four different Q-switched neodymium-YAG lasers. The laser was fired at fixed human trabecular meshwork specimens at a range of energy settings for each laser and the characteristics and replicability of the lesions produced were analysed. Energy levels between 3 and 5 mJ were sufficient to produce fistulae into the canal of Schlemm with an approximately 50% success rate for each instrument. Images PMID:2706207

  19. Effect of transscleral neodymium: YAG cyclophotocoagulation on intraocular lenses

    SciTech Connect

    Blomquist, P.H.; Gross, R.L.; Koch, D.D. )

    1990-03-01

    A neodymium: YAG laser operating in the thermal mode was used to irradiate isolated intraocular lenses (IOLs) and to perform transscleral cyclophotocoagulation on pseudophakic autopsy eyes to investigate the potential damage to IOL haptics such irradiation may cause. In the isolated IOLs, 70 mJ of energy deformed and partially melted both polymethylmethacrylate (PMMA) and polypropylene haptics. One of the capsular-fixated PC-IOL haptics in an autopsy eye partially melted when irradiated with the maximum energy level (8.8 J), with the aiming beam focused 1 mm posterior to the limbus and maximal posterior focus offset.

  20. Macrophagic CD146 promotes foam cell formation and retention during atherosclerosis

    PubMed Central

    Luo, Yongting; Duan, Hongxia; Qian, Yining; Feng, Liqun; Wu, Zhenzhen; Wang, Fei; Feng, Jing; Yang, Dongling; Qin, Zhihai; Yan, Xiyun

    2017-01-01

    The persistence of cholesterol-engorged macrophages (foam cells) in the artery wall fuels the development of atherosclerosis. However, the mechanism that regulates the formation of macrophage foam cells and impedes their emigration out of inflamed plaques is still elusive. Here, we report that adhesion receptor CD146 controls the formation of macrophage foam cells and their retention within the plaque during atherosclerosis exacerbation. CD146 is expressed on the macrophages in human and mouse atheroma and can be upregulated by oxidized low-density lipoprotein (oxLDL). CD146 triggers macrophage activation by driving the internalization of scavenger receptor CD36 during lipid uptake. In response to oxLDL, macrophages show reduced migratory capacity toward chemokines CCL19 and CCL21; this capacity can be restored by blocking CD146. Genetic deletion of macrophagic CD146 or targeting of CD146 with an antibody result in much less complex plaques in high-fat diet-fed ApoE−/− mice by causing lipid-loaded macrophages to leave plaques. Collectively, our findings identify CD146 as a novel retention signal that traps macrophages within the artery wall, and a promising therapeutic target in atherosclerosis treatment. PMID:28084332

  1. Macrophagic CD146 promotes foam cell formation and retention during atherosclerosis.

    PubMed

    Luo, Yongting; Duan, Hongxia; Qian, Yining; Feng, Liqun; Wu, Zhenzhen; Wang, Fei; Feng, Jing; Yang, Dongling; Qin, Zhihai; Yan, Xiyun

    2017-03-01

    The persistence of cholesterol-engorged macrophages (foam cells) in the artery wall fuels the development of atherosclerosis. However, the mechanism that regulates the formation of macrophage foam cells and impedes their emigration out of inflamed plaques is still elusive. Here, we report that adhesion receptor CD146 controls the formation of macrophage foam cells and their retention within the plaque during atherosclerosis exacerbation. CD146 is expressed on the macrophages in human and mouse atheroma and can be upregulated by oxidized low-density lipoprotein (oxLDL). CD146 triggers macrophage activation by driving the internalization of scavenger receptor CD36 during lipid uptake. In response to oxLDL, macrophages show reduced migratory capacity toward chemokines CCL19 and CCL21; this capacity can be restored by blocking CD146. Genetic deletion of macrophagic CD146 or targeting of CD146 with an antibody result in much less complex plaques in high-fat diet-fed ApoE(-/-) mice by causing lipid-loaded macrophages to leave plaques. Collectively, our findings identify CD146 as a novel retention signal that traps macrophages within the artery wall, and a promising therapeutic target in atherosclerosis treatment.

  2. MicroRNA 146 (Mir146) modulates spermatogonial differentiation by retinoic acid in mice.

    PubMed

    Huszar, Jessica M; Payne, Christopher J

    2013-01-01

    Impaired biogenesis of microRNAs disrupts spermatogenesis and leads to infertility in male mice. Spermatogonial differentiation is a key step in spermatogenesis, yet the mechanisms that control this event remain poorly defined. In this study, we discovered microRNA 146 (Mir146) to be highly regulated during spermatogonial differentiation, a process dependent on retinoic acid (RA) signaling. Mir146 transcript levels were diminished nearly 180-fold in differentiating spermatogonia when compared with undifferentiated spermatogonia. Luciferase assays revealed the direct binding of Mir146 to the 3' untranslated region of the mediator complex subunit 1 (Med1), a coregulator of retinoid receptors (RARs and RXRs). Overexpression of Mir146 in cultured undifferentiated spermatogonia reduced Med1 transcript levels, as well as those of differentiation marker kit oncogene (Kit). MED1 protein was also diminished. Conversely, inhibition of Mir146 increased the levels of Kit. When undifferentiated spermatogonia were exposed to RA, Mir146 was downregulated along with a marker for undifferentiated germ cells, zinc finger and BTB domain containing 16 (Zbtb16; Plzf); Kit was upregulated. Overexpression of Mir146 in RA-treated spermatogonia inhibited the upregulation of Kit, stimulated by retinoic acid gene 8 (Stra8), and spermatogenesis- and oogenesis-specific basic helix-loop-helix 2 (Sohlh2). Inhibition of Mir146 in RA-treated spermatogonia greatly enhanced the upregulation of these genes. We conclude that Mir146 modulates the effects of RA on spermatogonial differentiation.

  3. 33 CFR 146.200 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... CONTINENTAL SHELF ACTIVITIES OPERATIONS Mobile Offshore Drilling Units § 146.200 Definitions. For the purpose... given by the Bureau of Ocean Energy Management, Regulation and Enforcement (BOE) to define the OCS...

  4. 33 CFR 146.200 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... CONTINENTAL SHELF ACTIVITIES OPERATIONS Mobile Offshore Drilling Units § 146.200 Definitions. For the purpose... given by the Bureau of Ocean Energy Management, Regulation and Enforcement (BOE) to define the OCS...

  5. 33 CFR 146.200 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... CONTINENTAL SHELF ACTIVITIES OPERATIONS Mobile Offshore Drilling Units § 146.200 Definitions. For the purpose... given by the Bureau of Ocean Energy Management, (BOEM) to define the OCS areas used to...

  6. 33 CFR 146.200 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... CONTINENTAL SHELF ACTIVITIES OPERATIONS Mobile Offshore Drilling Units § 146.200 Definitions. For the purpose... given by the Bureau of Ocean Energy Management, Regulation and Enforcement (BOE) to define the OCS...

  7. 9 CFR 146.21 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Commercial Table-Egg Layer Flocks § 146.21 Definitions. Table-egg layer. A domesticated chicken grown for the... domesticated chicken grown for the primary purpose of producing eggs for human consumption....

  8. 9 CFR 146.21 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Commercial Table-Egg Layer Flocks § 146.21 Definitions. Table-egg layer. A domesticated chicken grown for the... domesticated chicken grown for the primary purpose of producing eggs for human consumption....

  9. 9 CFR 146.21 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Commercial Table-Egg Layer Flocks § 146.21 Definitions. Table-egg layer. A domesticated chicken grown for the... domesticated chicken grown for the primary purpose of producing eggs for human consumption....

  10. 19 CFR 146.7 - Zone changes.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... qualifications, character, and experience of the operator and its principal officers. (f) The bond in § 146.6... operator or a zone user. If a list was previously furnished, the port director may make a written demand...

  11. 22 CFR 146.300 - Admission.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... discriminate against or exclude any person on the basis of pregnancy, childbirth, termination of pregnancy, or...) Subject to § 146.235(d), shall treat disabilities related to pregnancy, childbirth, termination of...

  12. 22 CFR 146.300 - Admission.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... discriminate against or exclude any person on the basis of pregnancy, childbirth, termination of pregnancy, or...) Subject to § 146.235(d), shall treat disabilities related to pregnancy, childbirth, termination of...

  13. 9 CFR 146.41 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...-Type Turkey Slaughter Plants § 146.41 Definitions. Meat-type turkey. A domesticated turkey grown for the primary purpose of producing meat. Meat-type turkey slaughter plant. A meat-type turkey slaughter...

  14. 9 CFR 146.41 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...-Type Turkey Slaughter Plants § 146.41 Definitions. Meat-type turkey. A domesticated turkey grown for the primary purpose of producing meat. Meat-type turkey slaughter plant. A meat-type turkey slaughter...

  15. 9 CFR 146.41 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...-Type Turkey Slaughter Plants § 146.41 Definitions. Meat-type turkey. A domesticated turkey grown for the primary purpose of producing meat. Meat-type turkey slaughter plant. A meat-type turkey slaughter...

  16. 9 CFR 146.41 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...-Type Turkey Slaughter Plants § 146.41 Definitions. Meat-type turkey. A domesticated turkey grown for the primary purpose of producing meat. Meat-type turkey slaughter plant. A meat-type turkey slaughter...

  17. 9 CFR 146.41 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...-Type Turkey Slaughter Plants § 146.41 Definitions. Meat-type turkey. A domesticated turkey grown for the primary purpose of producing meat. Meat-type turkey slaughter plant. A meat-type turkey...

  18. Abundance analysis of neodymium in the solar atmosphere

    NASA Astrophysics Data System (ADS)

    Abdelkawy, Ali G. A.; Shaltout, Abdelrazek M. K.; Beheary, M. M.; Bakry, A.

    2017-10-01

    Based on non-local thermodynamical equilibrium (NLTE) calculations, the solar neodymium (Nd) content was found based on a model atom of singly ionized neodymium (Nd ii) containing 153 energy levels and 42 line transitions plus the ground state of Nd iii. Here, we re-derive the solar Nd abundance using the model of the solar photosphere of Holweger & Müller.We succeed in selecting a good sample line list, relying on 20 Nd ii solar lines together with the most accurate transition probabilities measured experimentally and available observational data. With damping parameters obtained from the literature, we find a mean NLTE solar photospheric Nd abundance of log ɛNd(1D) = 1.43 ± 0.16, which is in excellent agreement with the meteoritic value (log ɛNd = 1.45 ± 0.02). For a set of selected Nd ii lines, the NLTE abundance correction is found to be +0.01 dex compared with the standard LTE effect. The influence of collisional interactions with electrons and neutral hydrogen atoms is investigated in detail.

  19. Incorporation of cerium and neodymium in uranyl phases

    NASA Astrophysics Data System (ADS)

    Kim, Cheol-Woon; Wronkiewicz, David J.; Finch, Robert J.; Buck, Edgar C.

    2006-07-01

    The potential for incorporating rare earth elements (REE) into/onto crystalline compounds has been evaluated by precipitating uranyl phases from aqueous solutions containing either cerium or neodymium. These REEs serve both as monitors for evaluating the potential repository behavior of REE radionuclides, and as surrogate elements for actinides (e.g., Ce 4+ and Nd 3+ for Pu 4+ and Am 3+, respectively). The present experiments examined the behavior of REE in the presence of ianthinite ([U24+(UO2)4O6(OH)4(H2O)4](H2O)5), becquerelite (Ca(UO 2) 6O 4(OH) 6(H 2O) 8), and other uranyl hydroxide compounds commonly noted as alteration products during the corrosion of UO 2, spent nuclear fuel, and naturally occurring uraninite. The results of these experiments demonstrate that significant quantities of both cerium ( Kd = 1020) and neodymium ( Kd = 840) are incorporated within the uranium alteration phases and suggest that ionic substitution and/or adsorption to the uranyl phases can play a key role in the limiting the mobility of REE (and by analogy, actinide elements) in a nuclear waste repository.

  20. Magnetic behaviour of Neodymium-substituted strontium hexaferrite

    NASA Astrophysics Data System (ADS)

    Bhat, Bilal Hamid; Want, Basharat

    2016-03-01

    Neodymium-substituted strontium hexaferrites, Sr1- x Nd x Fe12O19 ( x = 0, 0.05, 0.10, 0.15, 0.20), have been successfully synthesized by using citrate precursor method. The synthesized samples were characterized by X-ray diffraction, Transmission electron microscopy and vibrating sample magnetometry. The X-ray diffraction results show that the prepared samples are crystalline in nature and are of single phase with the space group P63/mmc. Transmission electron microscopy results show that the prepared sample is composed of fine nanoparticles with an average size of 80 nm. The effect on magnetic behaviour of strontium hexaferrite with neodymium substitution was analysed by using first-order reversal curves (FORCs). FORC analysis was done in order to know the domain state of magnetization of the nanoparticles and the nature of magnetic interactions among the particles. FORC diagrams depict a single peak, suggesting that the substituted systems are formed of interacting nanoparticles.

  1. Twenty-Eight-Day Repeated Inhalation Toxicity Study of Nano-Sized Neodymium Oxide in Male Sprague-Dawley Rats.

    PubMed

    Kim, Yong-Soon; Lim, Cheol-Hong; Shin, Seo-Ho; Kim, Jong-Choon

    2017-07-01

    Neodymium is a future-oriented material due to its unique properties, and its use is increasing in various industrial fields worldwide. However, the toxicity caused by repeated exposure to this metal has not been studied in detail thus far. The present study was carried out to investigate the potential inhalation toxicity of nano-sized neodymium oxide (Nd2O3) following a 28-day repeated inhalation exposure in male Sprague-Dawley rats. Male rats were exposed to nano-sized Nd2O3-containing aerosols via a nose-only inhalation system at doses of 0 mg/m(3), 0.5 mg/m(3), 2.5 mg/m(3), and 10 mg/m(3) for 6 hr/day, 5 days/week over a 28-day period, followed by a 28-day recovery period. During the experimental period, clinical signs, body weight, hematologic parameters, serum biochemical parameters, necropsy findings, organ weight, and histopathological findings were examined; neodymium distribution in the major organs and blood, bronchoalveolar lavage fluid (BALF), and oxidative stress in lung tissues were analyzed. Most of the neodymium was found to be deposited in lung tissues, showing a dose-dependent relationship. Infiltration of inflammatory cells and pulmonary alveolar proteinosis (PAP) were the main observations of lung histopathology. Infiltration of inflammatory cells was observed in the 2.5 mg/m(3) and higher dose treatment groups. PAP was observed in all treatment groups accompanied by an increase in lung weight, but was observed to a lesser extent in the 0.5 mg/m(3) treatment group. In BALF analysis, total cell counts, including macrophages and neutrophils, lactate dehydrogenase, albumin, interleukin-6, and tumor necrosis factor-alpha, increased significantly in all treatment groups. After a 4-week recovery period, these changes were generally reversed in the 0.5 mg/m(3) group, but were exacerbated in the 10 mg/m(3) group. The lowest-observed-adverse-effect concentration of nano-sized Nd2O3 was determined to be 0.5 mg/m(3), and the target organ was determined to

  2. Twenty-Eight-Day Repeated Inhalation Toxicity Study of Nano-Sized Neodymium Oxide in Male Sprague-Dawley Rats

    PubMed Central

    Kim, Yong-Soon; Lim, Cheol-Hong; Shin, Seo-Ho; Kim, Jong-Choon

    2017-01-01

    Neodymium is a future-oriented material due to its unique properties, and its use is increasing in various industrial fields worldwide. However, the toxicity caused by repeated exposure to this metal has not been studied in detail thus far. The present study was carried out to investigate the potential inhalation toxicity of nano-sized neodymium oxide (Nd2O3) following a 28-day repeated inhalation exposure in male Sprague-Dawley rats. Male rats were exposed to nano-sized Nd2O3-containing aerosols via a nose-only inhalation system at doses of 0 mg/m3, 0.5 mg/m3, 2.5 mg/m3, and 10 mg/m3 for 6 hr/day, 5 days/week over a 28-day period, followed by a 28-day recovery period. During the experimental period, clinical signs, body weight, hematologic parameters, serum biochemical parameters, necropsy findings, organ weight, and histopathological findings were examined; neodymium distribution in the major organs and blood, bronchoalveolar lavage fluid (BALF), and oxidative stress in lung tissues were analyzed. Most of the neodymium was found to be deposited in lung tissues, showing a dose-dependent relationship. Infiltration of inflammatory cells and pulmonary alveolar proteinosis (PAP) were the main observations of lung histopathology. Infiltration of inflammatory cells was observed in the 2.5 mg/m3 and higher dose treatment groups. PAP was observed in all treatment groups accompanied by an increase in lung weight, but was observed to a lesser extent in the 0.5 mg/m3 treatment group. In BALF analysis, total cell counts, including macrophages and neutrophils, lactate dehydrogenase, albumin, interleukin-6, and tumor necrosis factor-alpha, increased significantly in all treatment groups. After a 4-week recovery period, these changes were generally reversed in the 0.5 mg/m3 group, but were exacerbated in the 10 mg/m3 group. The lowest-observed-adverse-effect concentration of nano-sized Nd2O3 was determined to be 0.5 mg/m3, and the target organ was determined to be the lung

  3. Association of microRNA 146 with middle ear hyperplasia in pediatric otitis media.

    PubMed

    Samuels, Tina L; Yan, Justin; Khampang, Pawjai; MacKinnon, Alexander; Hong, Wenzhou; Johnston, Nikki; Kerschner, Joseph E

    2016-09-01

    Toll-like receptor signaling activated by bacterial otitis media pathogens in the middle ear has been shown to play a key role in OM susceptibility, pathogenesis and recovery. Recent studies implicate microRNA 146 (miR-146) in regulation of inflammation via negative feedback of toll-like receptor signaling (TLR) in a wide variety of tissues, however its involvement in otitis media is unknown. Human middle ear epithelial cells were stimulated with proinflammatory cytokines, interleukin 1 beta or tumor necrosis factor alpha, for two to twenty-four hours. Middle ear biopsies were collected from children with otitis media with effusion (n = 20), recurrent otitis media (n = 9), and control subjects undergoing cochlear implantation (n = 10). miR-146a, miR-146b expression was assayed by quantitative PCR (qPCR). Expression of miR-146 targets involved in TLR signaling, IRAK1 and TRAF6, was assayed by qPCR in middle ear biopsies. Middle ear biopsies were cryosectioned and epithelial thickness measured by a certified pathologist. Proinflammatory cytokines induced expression of miR-146 in middle ear epithelial cells in vitro. Middle ear miR-146a and miR-146b expression was elevated in otitis media patients relative to control subjects and correlated with middle ear epithelial thickness. A trend towards inverse correlation was observed between miR-146 and TRAF6 expression in the clinical population. This report is the first to assess miRNA expression in a clinical population with OM. Findings herein suggest miR-146 may play a role in OM. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  4. Soluble melanoma cell adhesion molecule (sMCAM/sCD146) promotes angiogenic effects on endothelial progenitor cells through angiomotin.

    PubMed

    Stalin, Jimmy; Harhouri, Karim; Hubert, Lucas; Subrini, Caroline; Lafitte, Daniel; Lissitzky, Jean-Claude; Elganfoud, Nadia; Robert, Stéphane; Foucault-Bertaud, Alexandrine; Kaspi, Elise; Sabatier, Florence; Aurrand-Lions, Michel; Bardin, Nathalie; Holmgren, Lars; Dignat-George, Françoise; Blot-Chabaud, Marcel

    2013-03-29

    The melanoma cell adhesion molecule (CD146) contains a circulating proteolytic variant (sCD146), which is involved in inflammation and angiogenesis. Its circulating level is modulated in different pathologies, but its intracellular transduction pathways are still largely unknown. Using peptide pulldown and mass spectrometry, we identified angiomotin as a sCD146-associated protein in endothelial progenitor cells (EPC). Interaction between angiomotin and sCD146 was confirmed by enzyme-linked immunosorbent assay (ELISA), homogeneous time-resolved fluorescence, and binding of sCD146 on both immobilized recombinant angiomotin and angiomotin-transfected cells. Silencing angiomotin in EPC inhibited sCD146 angiogenic effects, i.e. EPC migration, proliferation, and capacity to form capillary-like structures in Matrigel. In addition, sCD146 effects were inhibited by the angiomotin inhibitor angiostatin and competition with recombinant angiomotin. Finally, binding of sCD146 on angiomotin triggered the activation of several transduction pathways that were identified by antibody array. These results delineate a novel signaling pathway where sCD146 binds to angiomotin to stimulate a proangiogenic response. This result is important to find novel target cells of sCD146 and for the development of therapeutic strategies based on EPC in the treatment of ischemic diseases.

  5. Soluble Melanoma Cell Adhesion Molecule (sMCAM/sCD146) Promotes Angiogenic Effects on Endothelial Progenitor Cells through Angiomotin*

    PubMed Central

    Stalin, Jimmy; Harhouri, Karim; Hubert, Lucas; Subrini, Caroline; Lafitte, Daniel; Lissitzky, Jean-Claude; Elganfoud, Nadia; Robert, Stéphane; Foucault-Bertaud, Alexandrine; Kaspi, Elise; Sabatier, Florence; Aurrand-Lions, Michel; Bardin, Nathalie; Holmgren, Lars; Dignat-George, Françoise; Blot-Chabaud, Marcel

    2013-01-01

    The melanoma cell adhesion molecule (CD146) contains a circulating proteolytic variant (sCD146), which is involved in inflammation and angiogenesis. Its circulating level is modulated in different pathologies, but its intracellular transduction pathways are still largely unknown. Using peptide pulldown and mass spectrometry, we identified angiomotin as a sCD146-associated protein in endothelial progenitor cells (EPC). Interaction between angiomotin and sCD146 was confirmed by enzyme-linked immunosorbent assay (ELISA), homogeneous time-resolved fluorescence, and binding of sCD146 on both immobilized recombinant angiomotin and angiomotin-transfected cells. Silencing angiomotin in EPC inhibited sCD146 angiogenic effects, i.e. EPC migration, proliferation, and capacity to form capillary-like structures in Matrigel. In addition, sCD146 effects were inhibited by the angiomotin inhibitor angiostatin and competition with recombinant angiomotin. Finally, binding of sCD146 on angiomotin triggered the activation of several transduction pathways that were identified by antibody array. These results delineate a novel signaling pathway where sCD146 binds to angiomotin to stimulate a proangiogenic response. This result is important to find novel target cells of sCD146 and for the development of therapeutic strategies based on EPC in the treatment of ischemic diseases. PMID:23389031

  6. Origin of the Sudbury Complex by meteoritic impact: Neodymium isotopic evidence

    USGS Publications Warehouse

    Faggart, B.E.; Basu, A.R.; Tatsumoto, M.

    1985-01-01

    Samarium-neodymium isotopic data on whole rocks and minerals of the Sudbury Complex in Canada gave an igneous crystallization age of 1840 ?? 21 ?? 106 years. The initial epsilon neodymium values for 15 whole rocks are similar to those for average upper continental crust, falling on the crustal trend of neodymium isotopic evolution as defined by shales. The rare earth element concentration patterns of Sudbury rocks are also similar to upper crustal averages. These data suggest that the Sudbury Complex formed from melts generated in the upper crust and are consistent with a meteoritic impact.

  7. Electrolytic production of neodymium without perfluorinated carbon compounds on the offgases

    DOEpatents

    Keller, Rudolf; Larimer, Kirk T.

    1998-01-01

    A method of producing neodymium in an electrolytic cell without formation of perfluorinated carbon gases (PFCs), the method comprising the steps of providing an electrolyte in the electrolytic cell and providing an anode in an anode region of the electrolyte and providing a cathode in a cathode region of the electrolytic cell. Dissolving an oxygen-containing neodymium compound in the electrolyte in the anode region and maintaining a more intense electrolyte circulation in the anode region than in the cathode region. Passing an electrolytic current between said anode and said cathode and depositing neodymium metal at the cathode, preventing the formation of perfluorinated carbon gases by limiting anode over voltage.

  8. Efficient Recovery of Neodymium in Acidic System by Free-Standing Dual-Template Docking Oriented Ionic Imprinted Mesoporous Films.

    PubMed

    Zheng, Xudong; Zhang, Fusheng; Liu, Enli; Xu, Xuechao; Yan, Yongsheng

    2017-01-11

    Neodymium (Nd) is critical component of sintered neodymium magnets. Separation of Nd from consumer magnets has attracted a widespread attention. In this paper, we presented free-standing ionic imprinted mesoporous film materials for facile and highly efficient targeted separation of Nd from permanent magnets by dual-template docking oriented ionic imprinting (DTD-OII) method. DTD-OII is based on dual-template docking oriented molecular imprinting. Compared with conventional imprinting, this novel strategy does not need extra steps, but significantly advance imprinted efficiency. With optimization of functional monomer, our free-standing dual-template docking oriented ionic imprinted mesoporous films exhibit excellent adsorption of Nd by solid-liquid extraction. The Nd adsorption capacity for optimized films was 34.98 mg g(-1) under pH = 3.0. The distribution coefficient of Nd was 636 mL g(-1), which indicates films possess significantly selectivity of Nd. In addition, efficient dual-template docking oriented ionic imprinting makes films demonstrating an outstanding of reusability by cycle test, which appreciating their potential for industrial application.

  9. Magnetic field strength and reproducibility of neodymium magnets useful for transcranial static magnetic field stimulation of the human cortex.

    PubMed

    Rivadulla, Casto; Foffani, Guglielmo; Oliviero, Antonio

    2014-07-01

    The application of transcranial static magnetic field stimulation (tSMS) in humans reduces the excitability of the motor cortex for a few minutes after the end of stimulation. However, when tSMS is applied in humans, the cortex is at least 2 cm away, so most of the strength of the magnetic field will not reach the target. The main objective of the study was to measure the strength and reproducibility of static magnetic fields produced by commercial neodymium magnets. We measured the strength and reproducibility of static magnetic fields produced by four different types of neodymium cylindrical magnets using a magnetic field-to-voltage transducer. Magnetic field strength depended on magnet size. At distances <1.5 cm, the magnetic field strength was affected by the presence of central holes (potentially useful for recording electroencephalograms). At distances >1.5 cm, the measurements made on the cylinder axis and 1.5 cm off the axis were comparable. The reproducibility of the results (i.e., the consistency of the field strength across magnets of the same size) was very high. These measurements offer a quantitative empirical reference for developing devices useful for tSMS protocols in both humans and animals. © 2013 International Neuromodulation Society.

  10. miR-146a-mediated suppression of the inflammatory response in human adipocytes

    PubMed Central

    Roos, Julian; Enlund, Eveliina; Funcke, Jan-Bernd; Tews, Daniel; Holzmann, Karlheinz; Debatin, Klaus-Michael; Wabitsch, Martin; Fischer-Posovszky, Pamela

    2016-01-01

    The obesity-associated inflammation of white adipose tissue (WAT) is one of the factors leading to the development of related diseases such as insulin resistance and liver steatosis. Recently, microRNAs (miRNAs) were identified as important regulators of WAT functions. Herein, we cultured human Simpson-Golabi-Behmel syndrome (SGBS) adipocytes with macrophage-conditioned medium (MacCM) and performed an Affimetrix miRNA array to identify miRNAs differentially expressed under inflammatory conditions. We identified 24 miRNAs differentially expressed upon inflammation in human adipocytes and miR-146a was the most up-regulated miRNA species. In subcutaneous WAT, miR-146a was elevated in both human and murine obesity. Transfection of miR-146a mimics prevented the MacCM-induced inflammatory response in SGBS adipocytes as seen by reduced levels of IL-8 and MCP-1 mRNA and protein. We identified IRAK1 and TRAF6 as targets of miR-146a in human adipocytes and detected a reduced inflammation-induced activation of JNK and p38 upon miR-146a transfection. Taken together, we could show that miR-146a reduces the inflammatory response in human adipocytes. In a negative feedback loop miR-146a might contribute to the regulation of inflammatory processes in WAT and possibly prevent an overwhelming inflammatory response. PMID:27922090

  11. Dysregulation of endothelial colony-forming cell function by a negative feedback loop of circulating miR-146a and -146b in cardiovascular disease patients

    PubMed Central

    Chang, Ting-Yu; Tsai, Wei-Chi; Huang, Tse-Shun; Su, Shu-Han; Chang, Chih-Young; Ma, Hsiu-Yen; Wu, Chun-Hsien; Yang, Chih-Yung; Lin, Chi-Hung; Huang, Po-Hsun; Cheng, Cheng-Chung; Wang, Hsei-Wei

    2017-01-01

    Functional impairment of endothelial colony-forming cells (ECFCs), a specific cell lineage of endothelial progenitor cells (EPCs) is highly associated with the severity of coronary artery disease (CAD), the most common type of cardiovascular disease (CVD). Emerging evidence show that circulating microRNAs (miRNAs) in CAD patients’ body fluid hold a great potential as biomarkers. However, our knowledge of the role of circulating miRNA in regulating the function of ECFCs and the progression of CAD is still in its infancy. We showed that when ECFCs from healthy volunteers were incubated with conditioned medium or purified exosomes of cultured CAD ECFCs, the secretory factors from CAD ECFCs dysregulated migration and tube formation ability of healthy ECFCs. It is known that exosomes influence the physiology of recipient cells by introducing RNAs including miRNAs. By using small RNA sequencing (smRNA-seq), we deciphered the circulating miRNome in the plasma of healthy individual and CAD patients, and found that the plasma miRNA spectrum from CAD patients was significantly different from that of healthy control. Interestingly, smRNA-seq of both healthy and CAD ECFCs showed that twelve miRNAs that had a higher expression in the plasma of CAD patients also showed higher expression in CAD ECFCs when compared with healthy control. This result suggests that these miRNAs may be involved in the regulation of ECFC functions. For identification of potential mRNA targets of the differentially expressed miRNA in CAD patients, cDNA microarray analysis was performed to identify the angiogenesis-related genes that were down-regulated in CAD ECFCs and Pearson’s correlation were used to identify miRNAs that were negatively correlated with the identified angiogenesis-related genes. RT-qPCR analysis of the five miRNAs that negatively correlated with the down-regulated angiogenesis-related genes in plasma and ECFC of CAD patients showed miR-146a-5p and miR-146b-5p up

  12. Analysis of the structure and Mössbauer study of the neodymium substitution in the Sr-hexaferrite

    NASA Astrophysics Data System (ADS)

    Pérez-Juache, T. J.; Guerrero, A. L.; Cabal-Velarde, J. G.; Mirabal-García, M.; Palomares-Sánchez, S. A.; Matutes-Aquino, J. A.

    2016-12-01

    This work reads on the obtainment of the strontium hexaferrite substituted with neodymium in its pure phase using the solid state reaction method. The solubility of neodymium on the strontium hexaferrite was investigated according with the formula Sr1-xNdxFe12O19, for x=0.00, 0.05, 0.10, 0.15, 0.20 and 0.25. Results indicate that neodymium is soluble in the hexaferrite until x=0.15. In samples with higher neodymium content there are traces of secondary phases. Analysis of magnetic and structural properties was performed in function of the neodymium content, always in its solubility range. From the structural properties, it was observed that the addition of a little neodymium quantity in the Sr-hexaferrite causes an important reduction of the unit cell volume. Also, magnetic properties are strongly linked to the structural behavior, in this case a trend to reduce the magnetization of the samples was detected when neodymium content increased, which can be explained in terms of fluctuations of the superexchange coupling conducted by the neodymium interactions with the structure. Mössbauer analysis was carried out in order to analyze the effects of the neodymium substitution on the hyperfine parameters, as well as to confirm the preferential site of the neodymium substitution in the Sr-hexaferrite.

  13. A new contact neodymium: YAG laser for cyclophotocoagulation

    SciTech Connect

    Iwach, A.G.; Drake, M.V.; Hoskins, H.D. Jr.; Schuster, B.L.; Vassiliadis, A.; Crawford, J.B.; Hennings, D.R. )

    1991-06-01

    A newly developed compact (40 kg), self-contained contact Neodymium:YAG laser produces high-peak, high-energy (800 mJ/pulse), short (1.0 millisecond) pulses with 1 to 3 pulses/exposure. Energy is delivered via a 320-microns cleaved quartz fiber optic probe. Cyclophotocoagulation was performed in five eyes of three medium-sized Dutch-pigmented rabbits. The eyes received exposures of 1 to 3 pulses/exposure. Energy delivered ranged from 100 to 800 mJ/pulse. Histopathology revealed ciliary body disruption and hemorrhage with no damage to overlying sclera. When used for transscleral cyclodiathermy in the rabbit, the laser created significant ciliary body disruption with minimal scleral injury.

  14. Isotope enrichment by frequency-tripled temperature tuned neodymium laser photolysis of formaldehyde

    DOEpatents

    Marling, John B.

    1977-01-01

    Enrichment of carbon, hydrogen and/or oxygen isotopes by means of isotopically selective photo-predissociation of formaldehyde is achieved by irradiation provided by a frequency-tripled, temperature tuned neodymium laser.

  15. Modification of neodymium-doped ZnO hybrid nanoparticles under mild hydrothermal conditions.

    PubMed

    Shahmoradi, Behzad; Soga, K; Ananda, S; Somashekar, R; Byrappa, K

    2010-07-01

    The morphology and particle size of neodymium-doped ZnO hybrid nanoparticles were tailored through fabrication under mild hydrothermal conditions (T = 150-250 degrees C, P = autogeneous, t = 18 h) for the first time using two surface modifiers: caprylic acid and n-butylamine. Characterization of these nanoparticles was carried out using powder XRD, FTIR, SEM, zeta-potential analysis and UV-vis spectroscopy. The results revealed that modification of ZnO nanoparticles using neodymium as a dopant and caprylic acid or n-butylamine as a surfactant could change the optical and physical properties of the surface-modified neodymium-doped ZnO hybrid nanoparticles. The work proved the efficiency of caprylic acid and n-butylamine as suitable surfactants for surface modification of neodymium-doped ZnO hybrid nanoparticles.

  16. Microscale Demonstration of the Paramagnetism of Liquid Oxygen with a Neodymium Magnet

    ERIC Educational Resources Information Center

    Mattson, Bruce

    2007-01-01

    A microscale classroom demonstration of the paramagnetic behavior of various samples of liquid oxygen with neodymium magnet is being presented. The experiment should be done with extreme caution, as liquid oxygen reacts violently with organic matters.

  17. Microscale Demonstration of the Paramagnetism of Liquid Oxygen with a Neodymium Magnet

    ERIC Educational Resources Information Center

    Mattson, Bruce

    2007-01-01

    A microscale classroom demonstration of the paramagnetic behavior of various samples of liquid oxygen with neodymium magnet is being presented. The experiment should be done with extreme caution, as liquid oxygen reacts violently with organic matters.

  18. 21 CFR 146.140 - Pasteurized orange juice.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Pasteurized orange juice. 146.140 Section 146.140... and Beverages § 146.140 Pasteurized orange juice. (a) Pasteurized orange juice is the food prepared from unfermented juice obtained from mature oranges as specified in § 146.135, to which may be...

  19. 21 CFR 146.150 - Canned concentrated orange juice.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Canned concentrated orange juice. 146.150 Section... Fruit Juices and Beverages § 146.150 Canned concentrated orange juice. (a) Canned concentrated orange... labeling of ingredients prescribed for frozen concentrated orange juice by § 146.146, except that it is...

  20. 21 CFR 146.140 - Pasteurized orange juice.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Pasteurized orange juice. 146.140 Section 146.140... and Beverages § 146.140 Pasteurized orange juice. (a) Pasteurized orange juice is the food prepared from unfermented juice obtained from mature oranges as specified in § 146.135, to which may be...

  1. 21 CFR 146.150 - Canned concentrated orange juice.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 2 2013-04-01 2013-04-01 false Canned concentrated orange juice. 146.150 Section... Fruit Juices and Beverages § 146.150 Canned concentrated orange juice. (a) Canned concentrated orange... labeling of ingredients prescribed for frozen concentrated orange juice by § 146.146, except that it is...

  2. 21 CFR 146.150 - Canned concentrated orange juice.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 2 2012-04-01 2012-04-01 false Canned concentrated orange juice. 146.150 Section... Fruit Juices and Beverages § 146.150 Canned concentrated orange juice. (a) Canned concentrated orange... labeling of ingredients prescribed for frozen concentrated orange juice by § 146.146, except that it is...

  3. 21 CFR 146.140 - Pasteurized orange juice.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 2 2013-04-01 2013-04-01 false Pasteurized orange juice. 146.140 Section 146.140... and Beverages § 146.140 Pasteurized orange juice. (a) Pasteurized orange juice is the food prepared from unfermented juice obtained from mature oranges as specified in § 146.135, to which may be...

  4. 21 CFR 146.140 - Pasteurized orange juice.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 2 2012-04-01 2012-04-01 false Pasteurized orange juice. 146.140 Section 146.140... and Beverages § 146.140 Pasteurized orange juice. (a) Pasteurized orange juice is the food prepared from unfermented juice obtained from mature oranges as specified in § 146.135, to which may be...

  5. 21 CFR 146.140 - Pasteurized orange juice.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 2 2014-04-01 2014-04-01 false Pasteurized orange juice. 146.140 Section 146.140... and Beverages § 146.140 Pasteurized orange juice. (a) Pasteurized orange juice is the food prepared from unfermented juice obtained from mature oranges as specified in § 146.135, to which may be...

  6. 21 CFR 146.150 - Canned concentrated orange juice.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Canned concentrated orange juice. 146.150 Section... Fruit Juices and Beverages § 146.150 Canned concentrated orange juice. (a) Canned concentrated orange... labeling of ingredients prescribed for frozen concentrated orange juice by § 146.146, except that it is not...

  7. 21 CFR 146.150 - Canned concentrated orange juice.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 2 2014-04-01 2014-04-01 false Canned concentrated orange juice. 146.150 Section... Fruit Juices and Beverages § 146.150 Canned concentrated orange juice. (a) Canned concentrated orange... labeling of ingredients prescribed for frozen concentrated orange juice by § 146.146, except that it is not...

  8. Silencing miR-146a influences B cells and ameliorates experimental autoimmune myasthenia gravis.

    PubMed

    Zhang, JunMei; Jia, Ge; Liu, Qun; Hu, Jue; Yan, Mei; Yang, BaiFeng; Yang, Huan; Zhou, WenBin; Li, Jing

    2015-01-01

    MicroRNAs have been shown to be important regulators of immune homeostasis as patients with aberrant microRNA expression appeared to be more susceptible to autoimmune diseases. We recently found that miR-146a was up-regulated in activated B cells in response to rat acetylcholine receptor (AChR) α-subunit 97-116 peptide, and this up-regulation was significantly attenuated by AntagomiR-146a. Our data also demonstrated that silencing miR-146a with its inhibitor AntagomiR-146a effectively ameliorated clinical myasthenic symptoms in mice with ongoing experimental autoimmune myasthenia gravis. Furthermore, multiple defects were observed after miR-146a was knocked down in B cells, including decreased anti-R97-116 antibody production and class switching, reduced numbers of plasma cells, memory B cells and B-1 cells, and weakened activation of B cells. Previously, miR-146a has been identified as a nuclear factor-κB-dependent gene and predicted to base pair with the tumour necrosis factor receptor-associated factor 6 (TRAF6) and interleukin-1 receptor-associated kinase 1 (IRAK1) genes to regulate the immune response. However, our study proved that miR-146a inhibition had no effect on the expression of TRAF6 and IRAK1 in B cells. This result suggests that the function of miR-146a in B cells does not involve these two target molecules. We conclude that silencing miR-146a exerts its therapeutic effects by influencing the B-cell functions that contribute to the autoimmune pathogenesis of myasthenia gravis.

  9. Silencing miR-146a influences B cells and ameliorates experimental autoimmune myasthenia gravis

    PubMed Central

    Zhang, JunMei; Jia, Ge; Liu, Qun; Hu, Jue; Yan, Mei; Yang, BaiFeng; Yang, Huan; Zhou, WenBin; Li, Jing

    2015-01-01

    MicroRNAs have been shown to be important regulators of immune homeostasis as patients with aberrant microRNA expression appeared to be more susceptible to autoimmune diseases. We recently found that miR-146a was up-regulated in activated B cells in response to rat acetylcholine receptor (AChR) α-subunit 97-116 peptide, and this up-regulation was significantly attenuated by AntagomiR-146a. Our data also demonstrated that silencing miR-146a with its inhibitor AntagomiR-146a effectively ameliorated clinical myasthenic symptoms in mice with ongoing experimental autoimmune myasthenia gravis. Furthermore, multiple defects were observed after miR-146a was knocked down in B cells, including decreased anti-R97-116 antibody production and class switching, reduced numbers of plasma cells, memory B cells and B-1 cells, and weakened activation of B cells. Previously, miR-146a has been identified as a nuclear factor-κB-dependent gene and predicted to base pair with the tumour necrosis factor receptor-associated factor 6 (TRAF6) and interleukin-1 receptor-associated kinase 1 (IRAK1) genes to regulate the immune response. However, our study proved that miR-146a inhibition had no effect on the expression of TRAF6 and IRAK1 in B cells. This result suggests that the function of miR-146a in B cells does not involve these two target molecules. We conclude that silencing miR-146a exerts its therapeutic effects by influencing the B-cell functions that contribute to the autoimmune pathogenesis of myasthenia gravis. PMID:24962817

  10. Ultralow-threshold neodymium-doped microsphere lasers on a silicon chip

    NASA Astrophysics Data System (ADS)

    Ding, Yang; Fan, Huibo; Zhang, Xun; Jiang, Xiaoshun; Xiao, Min

    2017-07-01

    We demonstrate ultralow-threshold neodymium-doped silica microsphere lasers on a silicon chip with lasing wavelengths of 900 nm and 1060 nm. Neodymium-doped microsphere cavities are fabricated with a series of doping concentrations using silica sol-gel films. Experimentally, we observe single-mode lasing emissions from the high-Q microsphere cavities with a threshold of as low as 1.2 μW.

  11. Description of the traction characteristics of the neodymium compensators of the automatic vibration isolations

    NASA Astrophysics Data System (ADS)

    Gurova, E. G.; Panchenko, Y. V.; Gurov, M. G.

    2016-04-01

    In this paper the method of calculation of neodymium magnets was presented. The calculation of the neodymium magnets characteristics and stiffness correctors of the vibration isolator according to the requirements for vibration isolation devices with stiffness compensators was performed. This research has been performed with the support of the President scholarship for young scientists, order No. 184 of Ministry of education and science of the Russian Federation of the 10th of March 2015.

  12. Sol-Gel Synthesis and Characterization of Neodymium-Ion Doped Nanostructured Titania Thin Films

    DTIC Science & Technology

    2001-11-01

    reactions, which break down harmful organic pollutants to relatively harmless constituent chemicals. Semiconductor photocatalysis takes advantage of the...UNCLASSIFIED Defense Technical Information Center Compilation Part Notice ADP012201 TITLE: Sol-Gel Synthesis and Characterization of Neodymium-Ion...Society V5.2 SOL-GEL SYNTHESIS AND CHARACTERIZATION OF NEODYMIUM-ION DOPED NANOSTRUCTURED TITANIA THIN FILMS Andrew Burns~ln, W. Li("t, C. Baker"l) and

  13. Neodymium and strontium isotope evidence for crustal contamination of continental volcanics.

    PubMed

    Carter, S R; Evensen, N M; Hamilton, P J; O'nions, R K

    1978-11-17

    Combined neodymium and strontium isotope studies on Tertiary volcanics from northwest Scotland indicate that their parental mantle isotopic compositions have been substantially modified in many instances by contamination with the Precambrian continental crust through which they were erupted. The occurrence of samarium-neodymium and rubidium-strontium "pseudoisochrons" of different ages in these contaminated continental volcanics indicates that they are artifacts of the contamination processes and have no temporal significance with respect to mantle fractionation events.

  14. 75 FR 1560 - Airworthiness Directives; BAE Systems (Operations) Limited Model BAe 146 and Avro 146-RJ70A, 146...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-12

    ... related to the subject addressed by this AD), corrosion was found on the wing fixed leading edge structure... not have detected the corrosion or fatigue damage. Corrosion or fatigue damage in this area, if not... on a BAe 146 aircraft for a repair (not related to the subject addressed by this AD), corrosion was...

  15. Research and development of neodymium phosphate laser glass for high power laser application

    NASA Astrophysics Data System (ADS)

    Hu, Lili; He, Dongbing; Chen, Huiyu; Wang, Xin; Meng, Tao; Wen, Lei; Hu, Junjiang; Xu, Yongchun; Li, Shunguang; Chen, Youkuo; Chen, Wei; Chen, Shubin; Tang, Jingping; Wang, Biao

    2016-12-01

    Neodymium phosphate laser glass is a key optical element for high-power laser facility. In this work, the latest research and development of neodymium phosphate laser glass at the Shanghai Institute of Optics and Fine Mechanics (SIOM), China, is addressed. Neodymium phosphate laser glasses, N31, N41, NAP2, and NAP4, for high peak power and high average power applications have been developed. The properties of these glasses are presented and compared to those of other commercial neodymium phosphate laser glass from the Schott and Hoya companies and the Vavilov State Optical Institute (GOI), Russia. Continuous melting and edge cladding are the two key fabrication techniques that are used for the mass production of neodymium phosphate laser glass slabs. These techniques for the fabrication of large-aperture N31 neodymium phosphate laser glass slabs with low stress birefringence and residual reflectivity have been developed by us The effect of acid etching on the microstructure, optical transmission, and mechanical properties of NAP2 glass is also discussed.

  16. Research and development of neodymium phosphate laser glass for high power laser application

    NASA Astrophysics Data System (ADS)

    Hu, Lili; He, Dongbing; Chen, Huiyu; Wang, Xin; Meng, Tao; Wen, Lei; Hu, Junjiang; Xu, Yongchun; Li, Shunguang; Chen, Youkuo; Chen, Wei; Chen, Shubin; Tang, Jingping; Wang, Biao

    2017-01-01

    Neodymium phosphate laser glass is a key optical element for high-power laser facility. In this work, the latest research and development of neodymium phosphate laser glass at the Shanghai Institute of Optics and Fine Mechanics (SIOM), China, is addressed. Neodymium phosphate laser glasses, N31, N41, NAP2, and NAP4, for high peak power and high average power applications have been developed. The properties of these glasses are presented and compared to those of other commercial neodymium phosphate laser glass from the Schott and Hoya companies and the Vavilov State Optical Institute (GOI), Russia. Continuous melting and edge cladding are the two key fabrication techniques that are used for the mass production of neodymium phosphate laser glass slabs. These techniques for the fabrication of large-aperture N31 neodymium phosphate laser glass slabs with low stress birefringence and residual reflectivity have been developed by us The effect of acid etching on the microstructure, optical transmission, and mechanical properties of NAP2 glass is also discussed.

  17. 21 CFR 146.141 - Canned orange juice.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Canned orange juice. 146.141 Section 146.141 Food... Beverages § 146.141 Canned orange juice. (a) Canned orange juice is the food prepared from orange juice as specified in § 146.135 or frozen orange juice as specified in § 146.137, or a combination of both, to...

  18. 21 CFR 146.141 - Canned orange juice.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 2 2012-04-01 2012-04-01 false Canned orange juice. 146.141 Section 146.141 Food... Beverages § 146.141 Canned orange juice. (a) Canned orange juice is the food prepared from orange juice as specified in § 146.135 or frozen orange juice as specified in § 146.137, or a combination of both, to...

  19. 21 CFR 146.141 - Canned orange juice.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 2 2014-04-01 2014-04-01 false Canned orange juice. 146.141 Section 146.141 Food... Beverages § 146.141 Canned orange juice. (a) Canned orange juice is the food prepared from orange juice as specified in § 146.135 or frozen orange juice as specified in § 146.137, or a combination of both, to...

  20. 21 CFR 146.141 - Canned orange juice.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 2 2013-04-01 2013-04-01 false Canned orange juice. 146.141 Section 146.141 Food... Beverages § 146.141 Canned orange juice. (a) Canned orange juice is the food prepared from orange juice as specified in § 146.135 or frozen orange juice as specified in § 146.137, or a combination of both, to...

  1. 21 CFR 146.141 - Canned orange juice.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Canned orange juice. 146.141 Section 146.141 Food... Beverages § 146.141 Canned orange juice. (a) Canned orange juice is the food prepared from orange juice as specified in § 146.135 or frozen orange juice as specified in § 146.137, or a combination of both, to...

  2. 75 FR 49377 - Airworthiness Directives; BAE Systems (Operations) Limited Model Avro 146-RJ and BAe 146 Airplanes

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-13

    ...-012-AD; Amendment 39-16387; AD 2010-16-10] RIN 2120-AA64 Airworthiness Directives; BAE Systems (Operations) Limited Model Avro 146-RJ and BAe 146 Airplanes AGENCY: Federal Aviation Administration (FAA... has been identified regarding the interchanging of wing links on all BAe 146 & AVRO 146-RJ...

  3. Diffusion kinetics of samarium and neodymium in garnet, and a method for determining cooling rates of rocks

    PubMed

    Ganguly; Tirone; Hervig

    1998-08-07

    Experimental determinations of the diffusion coefficients of samarium and neodymium in almandine garnet and theoretical considerations show that one cannot assign a sufficiently restricted range of closure temperature, TC, to the samarium-neodymium decay system in garnet for the purpose of constraining the cooling rate. However, it is shown that the samarium-neodymium cooling age of garnet can be used to calculate both cooling rate and TC if the temperature and age at the peak metamorphic conditions are known.

  4. 9 CFR 146.51 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Commercial Upland Game Birds, Commercial Waterfowl, Raised-for-Release Upland Game Birds, and Raised-for-Release Waterfowl § 146.51 Definitions. Commercial upland game bird slaughter plant. A commercial upland game bird slaughter plant that is federally inspected or under State inspection that the...

  5. 9 CFR 146.51 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Commercial Upland Game Birds, Commercial Waterfowl, Raised-for-Release Upland Game Birds, and Raised-for-Release Waterfowl § 146.51 Definitions. Commercial upland game bird slaughter plant. A commercial upland game bird slaughter plant that is federally inspected or under State inspection that the...

  6. 9 CFR 146.52 - Participation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Commercial Upland Game Birds, Commercial Waterfowl, Raised-for-Release Upland Game Birds, and Raised-for-Release Waterfowl § 146.52 Participation. (a) Participating commercial upland game bird slaughter plants, commercial waterfowl slaughter plants, raised-for-release upland game bird premises, and...

  7. 9 CFR 146.52 - Participation.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... Commercial Upland Game Birds, Commercial Waterfowl, Raised-for-Release Upland Game Birds, and Raised-for-Release Waterfowl § 146.52 Participation. (a) Participating commercial upland game bird slaughter plants, commercial waterfowl slaughter plants, raised-for-release upland game bird premises, and...

  8. 9 CFR 146.52 - Participation.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Commercial Upland Game Birds, Commercial Waterfowl, Raised-for-Release Upland Game Birds, and Raised-for-Release Waterfowl § 146.52 Participation. (a) Participating commercial upland game bird slaughter plants, commercial waterfowl slaughter plants, raised-for-release upland game bird premises, and...

  9. 9 CFR 146.52 - Participation.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Commercial Upland Game Birds, Commercial Waterfowl, Raised-for-Release Upland Game Birds, and Raised-for-Release Waterfowl § 146.52 Participation. (a) Participating commercial upland game bird slaughter plants, commercial waterfowl slaughter plants, raised-for-release upland game bird premises, and...

  10. 9 CFR 146.51 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Commercial Upland Game Birds, Commercial Waterfowl, Raised-for-Release Upland Game Birds, and Raised-for-Release Waterfowl § 146.51 Definitions. Commercial upland game bird slaughter plant. A commercial upland game bird slaughter plant that is federally inspected or under State inspection that the...

  11. 9 CFR 146.52 - Participation.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... Commercial Upland Game Birds, Commercial Waterfowl, Raised-for-Release Upland Game Birds, and Raised-for-Release Waterfowl § 146.52 Participation. (a) Participating commercial upland game bird slaughter plants, commercial waterfowl slaughter plants, raised-for-release upland game bird premises, and...

  12. 22 CFR 146.310 - Recruitment.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Relations DEPARTMENT OF STATE CIVIL RIGHTS NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Admission and....300 through 146.310 apply shall not discriminate on the basis of sex in the recruitment and...

  13. 40 CFR 146.61 - Applicability.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Waste Injection Wells § 146.61 Applicability. (a) This subpart establishes criteria and standards for underground injection control programs to regulate Class I hazardous waste injection wells. Unless otherwise... hazardous waste injection wells. (b) Definitions. Cone of influence means that area around the well within...

  14. 40 CFR 146.71 - Closure.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Waste Injection Wells § 146.71 Closure. (a) Closure Plan. The owner or operator of a Class I hazardous waste injection well shall prepare, maintain, and comply with a plan for closure of the well that meets... injection well who ceases injection temporarily, may keep the well open provided he: (i) Has received...

  15. 40 CFR 146.67 - Operating requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Hazardous Waste Injection Wells § 146.67 Operating requirements. (a) Except during stimulation, the owner or... injection well at all times. (e) Permit requirements for owners or operators of hazardous waste wells which... the well may be lacking mechanical integrity, the owner or operator shall: (1) Cease injection of...

  16. 40 CFR 146.65 - Construction requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... to Class I Hazardous Waste Injection Wells § 146.65 Construction requirements. (a) General. All existing and new Class I hazardous waste injection wells shall be constructed and completed to: (1) Prevent... over the design life of the well. (d) Tubing and packer. (1) All Class I hazardous waste injection...

  17. 40 CFR 146.51 - Applicability.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Wells § 146.51 Applicability. This subpart sets forth criteria and standards for underground injection control programs to regulate all injection not regulated in subparts B, C, D, and E. (a) Generally, wells... injection wells. (b) It also includes wells not covered in Class IV that inject radioactive material listed...

  18. 40 CFR 146.69 - Reporting requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ...) UNDERGROUND INJECTION CONTROL PROGRAM: CRITERIA AND STANDARDS Criteria and Standards Applicable to Class I Hazardous Waste Injection Wells § 146.69 Reporting requirements. Reporting requirements shall, at a minimum... integrity; (2) Any other test of the injection well conducted by the permittee if required by the Director...

  19. 40 CFR 146.65 - Construction requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... to Class I Hazardous Waste Injection Wells § 146.65 Construction requirements. (a) General. All existing and new Class I hazardous waste injection wells shall be constructed and completed to: (1) Prevent... over the design life of the well. (d) Tubing and packer. (1) All Class I hazardous waste injection...

  20. 40 CFR 146.71 - Closure.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... Waste Injection Wells § 146.71 Closure. (a) Closure Plan. The owner or operator of a Class I hazardous waste injection well shall prepare, maintain, and comply with a plan for closure of the well that meets... injection well who ceases injection temporarily, may keep the well open provided he: (i) Has received...

  1. 40 CFR 146.61 - Applicability

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Waste Injection Wells § 146.61 Applicability (a) This subpart establishes criteria and standards for underground injection control programs to regulate Class I hazardous waste injection wells. Unless otherwise... hazardous waste injection wells. (b) Definitions. Cone of influence means that area around the well within...

  2. 40 CFR 146.69 - Reporting requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ...) UNDERGROUND INJECTION CONTROL PROGRAM: CRITERIA AND STANDARDS Criteria and Standards Applicable to Class I Hazardous Waste Injection Wells § 146.69 Reporting requirements. Reporting requirements shall, at a minimum... integrity; (2) Any other test of the injection well conducted by the permittee if required by the Director...

  3. 40 CFR 146.51 - Applicability.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Wells § 146.51 Applicability. This subpart sets forth criteria and standards for underground injection control programs to regulate all injection not regulated in subparts B, C, D, and E. (a) Generally, wells... injection wells. (b) It also includes wells not covered in Class IV that inject radioactive material listed...

  4. 40 CFR 146.51 - Applicability.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Wells § 146.51 Applicability. This subpart sets forth criteria and standards for underground injection control programs to regulate all injection not regulated in subparts B, C, D, and E. (a) Generally, wells... injection wells. (b) It also includes wells not covered in Class IV that inject radioactive material listed...

  5. 40 CFR 146.71 - Closure.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Waste Injection Wells § 146.71 Closure. (a) Closure Plan. The owner or operator of a Class I hazardous waste injection well shall prepare, maintain, and comply with a plan for closure of the well that meets... injection well who ceases injection temporarily, may keep the well open provided he: (i) Has received...

  6. 40 CFR 146.71 - Closure.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Waste Injection Wells § 146.71 Closure. (a) Closure Plan. The owner or operator of a Class I hazardous waste injection well shall prepare, maintain, and comply with a plan for closure of the well that meets... injection well who ceases injection temporarily, may keep the well open provided he: (i) Has received...

  7. 40 CFR 146.67 - Operating requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Hazardous Waste Injection Wells § 146.67 Operating requirements. (a) Except during stimulation, the owner or... injection well at all times. (e) Permit requirements for owners or operators of hazardous waste wells which... the well may be lacking mechanical integrity, the owner or operator shall: (1) Cease injection of...

  8. 40 CFR 146.61 - Applicability.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Waste Injection Wells § 146.61 Applicability. (a) This subpart establishes criteria and standards for underground injection control programs to regulate Class I hazardous waste injection wells. Unless otherwise... hazardous waste injection wells. (b) Definitions. Cone of influence means that area around the well within...

  9. 40 CFR 146.67 - Operating requirements.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Hazardous Waste Injection Wells § 146.67 Operating requirements. (a) Except during stimulation, the owner or... injection well at all times. (e) Permit requirements for owners or operators of hazardous waste wells which... the well may be lacking mechanical integrity, the owner or operator shall: (1) Cease injection of...

  10. 40 CFR 146.69 - Reporting requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ...) UNDERGROUND INJECTION CONTROL PROGRAM: CRITERIA AND STANDARDS Criteria and Standards Applicable to Class I Hazardous Waste Injection Wells § 146.69 Reporting requirements. Reporting requirements shall, at a minimum... integrity; (2) Any other test of the injection well conducted by the permittee if required by the Director...

  11. 40 CFR 146.65 - Construction requirements.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... to Class I Hazardous Waste Injection Wells § 146.65 Construction requirements. (a) General. All existing and new Class I hazardous waste injection wells shall be constructed and completed to: (1) Prevent... over the design life of the well. (d) Tubing and packer. (1) All Class I hazardous waste injection...

  12. 40 CFR 146.71 - Closure.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Waste Injection Wells § 146.71 Closure. (a) Closure Plan. The owner or operator of a Class I hazardous waste injection well shall prepare, maintain, and comply with a plan for closure of the well that meets... injection well who ceases injection temporarily, may keep the well open provided he: (i) Has received...

  13. 7 CFR 1260.146 - Vacancies.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; MISCELLANEOUS COMMODITIES), DEPARTMENT OF AGRICULTURE BEEF PROMOTION AND RESEARCH Beef Promotion and Research Order Cattlemen's Beef Promotion and Research Board § 1260.146 Vacancies. To fill any...

  14. 19 CFR 146.92 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... (CONTINUED) FOREIGN TRADE ZONES Petroleum Refineries in Foreign-Trade Subzones § 146.92 Definitions. (a... products to feedstocks for petroleum manufacturing in accordance with the Industry Standards of Potential.... “Feedstocks” means crude petroleum or intermediate product that is used in a petroleum refinery to make...

  15. 19 CFR 146.92 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... (CONTINUED) FOREIGN TRADE ZONES Petroleum Refineries in Foreign-Trade Subzones § 146.92 Definitions. (a... products to feedstocks for petroleum manufacturing in accordance with the Industry Standards of Potential.... “Feedstocks” means crude petroleum or intermediate product that is used in a petroleum refinery to make...

  16. 19 CFR 146.92 - Definitions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... (CONTINUED) FOREIGN TRADE ZONES Petroleum Refineries in Foreign-Trade Subzones § 146.92 Definitions. (a... products to feedstocks for petroleum manufacturing in accordance with the Industry Standards of Potential.... “Feedstocks” means crude petroleum or intermediate product that is used in a petroleum refinery to make...

  17. 19 CFR 146.92 - Definitions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... (CONTINUED) FOREIGN TRADE ZONES Petroleum Refineries in Foreign-Trade Subzones § 146.92 Definitions. (a... products to feedstocks for petroleum manufacturing in accordance with the Industry Standards of Potential.... “Feedstocks” means crude petroleum or intermediate product that is used in a petroleum refinery to make...

  18. 19 CFR 146.92 - Definitions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... (CONTINUED) FOREIGN TRADE ZONES Petroleum Refineries in Foreign-Trade Subzones § 146.92 Definitions. (a... products to feedstocks for petroleum manufacturing in accordance with the Industry Standards of Potential.... “Feedstocks” means crude petroleum or intermediate product that is used in a petroleum refinery to make...

  19. 27 CFR 646.146 - General requirements.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... CIGARETTES Records § 646.146 General requirements. Each distributor of cigarettes shall keep copies of... 60,000 cigarettes. Dividing a single agreement for the disposition of more than 60,000 cigarettes into the delivery of smaller components of 60,000 cigarettes or less does not exempt the distributor...

  20. 19 CFR 146.21 - General requirements.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... TREASURY (CONTINUED) FOREIGN TRADE ZONES Inventory Control and Recordkeeping System § 146.21 General requirements. (a) Systems capability. The operator shall maintain either manual or automated inventory control... English language copy of its written inventory control and recordkeeping systems procedures manual...

  1. 22 CFR 146.300 - Admission.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Relations DEPARTMENT OF STATE CIVIL RIGHTS NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Admission and Recruitment Prohibited § 146.300 Admission. (a) General. No person shall, on the basis of sex, be denied...

  2. 9 CFR 146.2 - Administration.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR COMMERCIAL POULTRY General Provisions § 146.2... State that does not participate in the Plan under a mutual understanding and agreement, in writing... standards, compatible with the Plan. (e) An authorized laboratory will follow the laboratory protocols...

  3. 9 CFR 146.2 - Administration.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... LIVESTOCK IMPROVEMENT NATIONAL POULTRY IMPROVEMENT PLAN FOR COMMERCIAL POULTRY General Provisions § 146.2... State that does not participate in the Plan under a mutual understanding and agreement, in writing... standards, compatible with the Plan. (e) An authorized laboratory will follow the laboratory protocols...

  4. 28 CFR 0.146 - Seals.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Personnel and Certain Administrative Matters § 0.146 Seals. The Director of the Federal Bureau of Investigation, the Director of the Bureau of Prisons, the Commissioner of Federal Prison Industries, the... Drug Enforcement Administration, the Director of the Bureau of Alcohol, Tobacco, Firearms,...

  5. 22 CFR 146.515 - Compensation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Relations DEPARTMENT OF STATE CIVIL RIGHTS NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 146.515 Compensation. A recipient shall not make or...

  6. 22 CFR 146.510 - Recruitment.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Relations DEPARTMENT OF STATE CIVIL RIGHTS NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 146.510 Recruitment. (a) Nondiscriminatory recruitment...

  7. 22 CFR 146.540 - Advertising.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Relations DEPARTMENT OF STATE CIVIL RIGHTS NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 146.540 Advertising. A recipient shall not in any...

  8. 40 CFR 146.12 - Construction requirements.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Section 146.12 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS... quarter mile of the well bore, an underground source of drinking water. (b) All Class I wells shall be... water. The casing and cement used in the construction of each newly drilled well shall be designed for...

  9. 9 CFR 146.42 - Participation.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...-Type Turkey Slaughter Plants § 146.42 Participation. (a) Participating meat-type turkey slaughter... provisions of this subpart D. (b) Meat-type turkey slaughter plants that slaughter fewer than 2 million meat-type turkeys in a 12-month period are exempt from the special provisions of this subpart D. ...

  10. 9 CFR 146.42 - Participation.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...-Type Turkey Slaughter Plants § 146.42 Participation. (a) Participating meat-type turkey slaughter... provisions of this subpart D. (b) Meat-type turkey slaughter plants that slaughter fewer than 2 million meat-type turkeys in a 12-month period are exempt from the special provisions of this subpart D. ...

  11. 9 CFR 146.42 - Participation.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...-Type Turkey Slaughter Plants § 146.42 Participation. (a) Participating meat-type turkey slaughter... provisions of this subpart D. (b) Meat-type turkey slaughter plants that slaughter fewer than 2 million meat-type turkeys in a 12-month period are exempt from the special provisions of this subpart D. ...

  12. 9 CFR 146.42 - Participation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...-Type Turkey Slaughter Plants § 146.42 Participation. (a) Participating meat-type turkey slaughter... provisions of this subpart D. (b) Meat-type turkey slaughter plants that slaughter fewer than 2 million meat-type turkeys in a 12-month period are exempt from the special provisions of this subpart D. ...

  13. 9 CFR 146.42 - Participation.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ...-Type Turkey Slaughter Plants § 146.42 Participation. (a) Participating meat-type turkey slaughter... provisions of this subpart D. (b) Meat-type turkey slaughter plants that slaughter fewer than 2 million meat-type turkeys in a 12-month period are exempt from the special provisions of this subpart D. ...

  14. 19 CFR 146.43 - Domestic status.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... (CONTINUED) FOREIGN TRADE ZONES Status of Merchandise in a Zone § 146.43 Domestic status. (a) General... and tax has been paid; or (3) Previously entered free of duty and tax. (b) Application. No application... and repair material, to a zone, except upon order of the Commissioner of Customs. No application...

  15. 19 CFR 146.43 - Domestic status.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... (CONTINUED) FOREIGN TRADE ZONES Status of Merchandise in a Zone § 146.43 Domestic status. (a) General... and tax has been paid; or (3) Previously entered free of duty and tax. (b) Application. No application... and repair material, to a zone, except upon order of the Commissioner of Customs. No application...

  16. 19 CFR 146.43 - Domestic status.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... (CONTINUED) FOREIGN TRADE ZONES Status of Merchandise in a Zone § 146.43 Domestic status. (a) General... and tax has been paid; or (3) Previously entered free of duty and tax. (b) Application. No application... and repair material, to a zone, except upon order of the Commissioner of Customs. No application...

  17. 9 CFR 146.51 - Definitions.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE...-Release Waterfowl § 146.51 Definitions. Commercial upland game bird slaughter plant. A commercial upland game bird slaughter plant that is federally inspected or under State inspection that the U.S...

  18. 9 CFR 146.51 - Definitions.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE...-Release Waterfowl § 146.51 Definitions. Commercial upland game bird slaughter plant. A commercial upland game bird slaughter plant that is federally inspected or under State inspection that the U.S...

  19. 22 CFR 146.525 - Fringe benefits.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 146.525 Fringe benefits. (a) “Fringe...

  20. 22 CFR 146.430 - Financial assistance.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Education Programs or Activities Prohibited § 146.430 Financial assistance. (a) General. Except as...

  1. 22 CFR 146.430 - Financial assistance.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Education Programs or Activities Prohibited § 146.430 Financial assistance. (a) General. Except as...

  2. 22 CFR 146.410 - Comparable facilities.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Education Programs or Activities Prohibited § 146.410 Comparable facilities. A recipient may...

  3. 22 CFR 146.410 - Comparable facilities.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Education Programs or Activities Prohibited § 146.410 Comparable facilities. A recipient may...

  4. 22 CFR 146.505 - Employment criteria.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Foreign Relations DEPARTMENT OF STATE CIVIL RIGHTS NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 146.505 Employment criteria. A recipient...

  5. 22 CFR 146.310 - Recruitment.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Relations DEPARTMENT OF STATE CIVIL RIGHTS NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Admission and....300 through 146.310 apply shall not discriminate on the basis of sex in the recruitment and...

  6. 22 CFR 146.510 - Recruitment.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... Relations DEPARTMENT OF STATE CIVIL RIGHTS NONDISCRIMINATION ON THE BASIS OF SEX IN EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Discrimination on the Basis of Sex in Employment in Education Programs or Activities Prohibited § 146.510 Recruitment. (a) Nondiscriminatory recruitment...

  7. Thermoluminescent sensitivity of single clad neodymium doped SiO2 optical fibres measured with 6 MeV photons

    NASA Astrophysics Data System (ADS)

    Saeed, M. A.; Hossain, I.; Hida, N.; Wagiran, H.

    2013-10-01

    This study investigates the thermoluminescent sensitivity of neodymium doped SiO2 optical fibre with various dose ranges from 0.5 Gy to 4.0 Gy by 6 MeV photon irradiations. The TL responses of the neodymium doped silica fibres are compared with available TLD-100 dosimeter in order to determine the suitability as a TL material. We found that the TLD-100 and neodymium doped silica fibre have a significant linear signal to dose relationship. Neodymium doped fibres sensitivity is approximately 11% of TLD-100.

  8. Near-infrared electroluminescence at room temperature from neodymium-doped gallium nitride thin films

    SciTech Connect

    Kim, Joo Han; Holloway, Paul H.

    2004-09-06

    Strong near-infrared (NIR) electroluminescence (EL) at room temperature from neodymium (Nd)-doped gallium nitride (GaN) thin films is reported. The Nd-doped GaN films were grown by radio-frequency planar magnetron cosputtering of separate GaN and metallic Nd targets in a pure nitrogen ambient. X-ray diffraction data did not identify the presence of any secondary phases and revealed that the Nd-doped GaN films had a highly textured wurtzite crystal structure with the c-axis normal to the surface of the film. The EL devices were fabricated with a thin-film multilayered structure of Al/Nd-doped GaN/Al{sub 2}O{sub 3}-TiO{sub 2}/indium-tin oxide and tested at room temperate. Three distinct NIR EL emission peaks were observed from the devices at 905, 1082, and 1364 nm, arising from the radiative relaxation of the {sup 4}F{sub 3sol2} excited-state energy level to the {sup 4}I{sub 9sol2}, {sup 4}I{sub 11sol2}, and {sup 4}I{sub 13sol2} levels of the Nd{sup 3+} ion, respectively. The threshold voltage for all the three emission peaks was {approx}150 V. The external power efficiency of the fabricated EL devices was {approx}1x10{sup -5} measured at 40 V above the threshold voltage.

  9. Influence of size of neodymium:yttrium-aluminium-garnet laser posterior capsulotomy on visual function.

    PubMed

    Hayashi, K; Nakao, F; Hayashi, H

    2010-01-01

    The aim of this study was to examine the influence that the size of a neodymium:yttrium-aluminium-garnet (Nd:YAG) laser capsulotomy performed for posterior capsule opacification (PCO) has on visual acuity (VA), and on contrast VA and that in the presence of glare (glare VA). A total of 41 consecutive eyes with PCO first underwent Nd:YAG laser capsulotomy of smaller than pupillary size, after which the capsulotomy was secondarily enlarged, 2 weeks later, to greater than pupillary size. Best-corrected VA, and contrast VA and glare VA under photopic and mesopic conditions were measured after the small and large capsulotomies were made. After enlargement, the mean capsulotomy area increased significantly from 4.8 to 15.3 mm(2) (P<0.0001). Best-corrected VA did not improve significantly after enlargement (P=0.1282). However, photopic contrast VA and glare VA at moderate to low contrast visual target before enlargement were significantly worse than those after enlargement (P

  10. Inhibiting CD146 by its Monoclonal Antibody AA98 Improves Radiosensitivity of Cervical Cancer Cells

    PubMed Central

    Cheng, Huawen

    2016-01-01

    Background Cervical cancer is one of the major causes of cancer death of females worldwide. Radiotherapy is considered effective for cervical cancer treatment, but the low radiosensitivity found in some cases severely affects therapeutic outcomes. This study aimed to reveal the role of CD146, an important adhesion molecule facilitating tumor angiogenesis, in regulating radiosensitivity of cervical cancer cells. Material/Methods CD146 protein expression was compared in normal cells, cervical cancer cells with lower radiosensitivity, and cervical cancer cells with higher sensitivity from cervical squamous cell carcinoma patients. Anti-CD146 monoclonal antibody AA98 was used to inhibit CD146 in human cervical cancer SiHa cells with relatively low radiosensitivity, and then the cell survival and apoptosis changes after radiation were detected by colony formation assay and flow cytometry. Results CD146 protein was significantly up-regulated in cervical cancer cells (P<0.001), especially in cancer cells with lower radiosensitivity. The SiHa cells treated with AA98 showed more obvious inhibition in cell survival (P<0.05) and promotion in cell apoptosis (P<0.01) after radiation, compared to the untreated cells. More dramatic changes in apoptotic factors Caspase 3 and Bcl-XL were also detected in AA98-treated cells. Conclusions These results indicate that inhibiting CD146 improves the effect of radiation in suppressing SiHa cells. This study shows the potential of CD146 as a target for increasing radiosensitivity of cervical cancer cells, which might allow improvement in treatment outcome in cervical cancer. Further studies are necessary for understanding the detailed mechanism of CD146 in regulating radiosensitivity. PMID:27647179

  11. MiR-146a promotes remyelination in a cuprizone model of demyelinating injury.

    PubMed

    Zhang, Jing; Zhang, Zheng Gang; Lu, Mei; Wang, Xinli; Shang, Xia; Elias, Stanton B; Chopp, Michael

    2017-04-21

    The death of mature oligodendrocytes (OLs) which are the sole myelinating cells of the central nervous system (CNS), leads to demyelination and functional deficits. Currently, there is lack of effective remyelination therapies for patients with demyelinating diseases. MicroRNAs (miRNAs) mediate OL function. We hypothesized that miR-146a, by inactivating interleukin-1 receptor-associated kinase 1 (IRAK1), promotes differentiation of oligodendrocyte progenitor cells (OPCs) and thereby enhances remyelination. To test this hypothesis, a demyelination model induced by a cuprizone (CPZ) diet was employed, in which C57BL/6J mice were fed with a CPZ diet for 5weeks. After termination of CPZ diet, the mice were randomly treated with continuous infusion of miR-146a mimics or mimic controls into the corpus callosum for 7days. Compared to the mimic control, infusion of miR-146a mimics facilitated remyelination assessed by increased myelin basic proteins in the corpus callosum, which was associated with augmentation of newly generated mature OLs. Infusion of miR-146a mimics also substantially elevated miR-146a levels in the corpus callosum and fluorescently tagged miR-146a mimics were mainly detected in OPCs. Western blot and double immmunofluorescent staining analysis showed that the miR-146a treatment considerably reduced IRAK1 protein levels and the number of IRAK1-positive cells, respectively. Collectively, these data indicate that exogenous miR-146a enhances remyelination, possibly by promoting OPCs to differentiate into myelinated OLs via targeting IRAK1.

  12. Upregulation of miR-146a by YY1 depletion correlates with delayed progression of prostate cancer

    PubMed Central

    Huang, Yeqing; Tao, Tao; Liu, Chunhui; Guan, Han; Zhang, Guangyuan; Ling, Zhixin; Zhang, Lei; Lu, Kai; Chen, Shuqiu; Xu, Bin; Chen, Ming

    2017-01-01

    Previously published studies explained that the excessive expression of miR-146a influences the prostate cancer (PCa) cells in terms of apoptosis, progression, and viability. Although miR-146a acts as a tumor suppressor, current knowledge on the molecular mechanisms that controls its expression in PCa is limited. In this study, gene set enrichment analysis (GSEA) showed negatively enriched expression of miR-146a target gene sets and positively enriched expression of gene sets suppressed by the enhancer of zeste homolog 2 (EZH2) after YY1 depletion in PCa cells. The current results demonstrated that the miR-146a levels in PCa tissues with high Gleason scores (>7) are significantly lower than those in PCa tissues with low Gleason scores (≤7), which were initially observed in the clinical specimens. An inverse relationship between YY1 and miR-146a expression was also observed. Experiments indicated the decrease in cell viability, proliferation, and promoting apoptosis after YY1 depletion, while through inhibiting miR-146a could alleviate the negative effect brought by YY1 depletion. We detected the reversed adjustment of YY1 to accommodate miR-146a transcriptions. On the basis of YY1 depletion, we determined that the expression of miR-146a increased after EZH2 knockdown. We validated the combination of YY1 and its interaction with EZH2 at the miR-146a promoter binding site, thereby prohibiting the transcriptional activity of miR-146a in PCa cells. Our results suggested that YY1 depletion repressed PCa cell viability and proliferation and induced apoptosis at least in a miR-146a-assisted manner. PMID:28101571

  13. Femtosecond diode-pumped mode-locked neodymium lasers

    NASA Astrophysics Data System (ADS)

    Kubeček, Václav; Jelínek, Michal; Čech, Miroslav; Vyhlídal, David; Su, Liangbi; Jiang, Dapeng; Ma, Fengkai; Qian, Xiaobo; Wang, Jingya; Xu, Jun

    2016-12-01

    Fluoride-type crystals (CaF2, SrF2) doped with neodymium Nd3+ and codoped with buffer ions for breaking clusters of active ions and increasing fluorescence efficiency, present interesting alternative as laser active media for the diode-pumped mode-locked lasers. In comparison with widely used materials as Nd:YAG or Nd:YVO4, they have broad emission spectra as well as longer fluorescence lifetime, in comparison with Nd:glass, SrF2 and CaF2 have better thermal conductivity. In spite of the fact, that this thermal conductivity decreases with Nd3+ doping concentration, these crystals are alternative for the Nd:glass in subpicosecond mode-locked laser systems. In this paper we review the basic results reported recently on these active materials and in the second part we present our results achieved in low power diode pumped passively mode locked lasers with Nd,La:CaF2 and Nd,Y:SrF2 crystals. The pulses as short as 258 fs at wavelength of 1057 nm were obtained in the first case, while 5 ps long pulses at 1065 nm were generated from the second laser system.

  14. Defluoridation of water using neodymium-modified chitosan.

    PubMed

    Yao, Ruihua; Meng, Fanping; Zhang, Longjun; Ma, Dongdong; Wang, Mingli

    2009-06-15

    The water containing high fluoride ions could do harm to human and environment. In this work, the applicability of neodymium-modified chitosan as adsorbents for the removal of excess fluoride ions from water was studied. The effect of various physico-chemical parameters such as temperature (283-323 K), pH (5-9), adsorbent dose (0.2-2.0 g L(-1)), particle size (0.10-0.50mm) and the presence of co-anions (NO(3)(-), Cl(-) and SO(4)(2-)) on removal of fluoride ions were studied. The equilibrium sorption data were fitted reasonably well for Langmuir isotherm model, the maximum equilibrium sorption had found to be 11.411-22.380 mg g(-1). Sorption dynamics study revealed that the pseudo-second-order was suitable to describe the kinetics process of fluoride ions sorption onto the adsorbent with the initial sorption rate 1.70, 2.10 and 2.67 mg g(-1)min(-1) at 283, 303 and 323 K, and the sorption process was complex, both the boundary of liquid film and intra-particle diffusion contributed to the rate-determining step. The used adsorbents could be regenerated in 24h by 4 g L(-1) of sodium hydroxide.

  15. Effect Of Neodymium Substitution In Structural Characteristics Of Magnesium Ferrite

    SciTech Connect

    Thankachan, Smitha; Binu, P. J.; Xavier, Sheena; Mohammed, E. M.

    2011-10-20

    The effect of Nd{sup 3+} substitution on the structural properties of Magnesium ferrite was studied in the series MgNd{sub x}Fe{sub 2-x}O{sub 4}, where x = 0 to 0.3 in steps of 0.05. The series was prepared by sol-gel technique which is one of the novel technique to prepare nanosized samples. Structural characterization was done using X-ray diffractometer and Fourier Transform Infrared Spectrometer. XRD analysis reveals the prepared samples are single phasic till x = 0.2. From x0 = .25, a secondary phase of iron neodymium oxide appears along with the spinel phase. Particle size calculation shows the prepared samples are in the 9nm to 11 nm regime. Lattice parameter was found to increase with concentration of Nd. XRD and FTIR analysis confirmed spinel structure of the prepared samples. XRF result shows the expected composition of prepared samples. The frequency dependence of the dielectric constant in the range 100 Hz--120MHz was also studied

  16. Dielectric properties of neodymium-modified PLZT ceramics

    NASA Astrophysics Data System (ADS)

    Płońska, M.; Adamczyk, M.

    2015-08-01

    Relaxor ferroelectrics or relaxors are a class of disordered single crystals and ceramic materials, of peculiar structure as well as properties. The commonly known examples of such materials are Pb(Mg,Nb)O3 (PMN) ceramics as well as single crystals. The second most extensively studied relaxor ceramics is lanthanum-doped lead zirconate-titanate, described as x/65/35 PLZT when lanthanum content is x = 6-10 at%. Throughout the last few decades, there has been an increasing interest in rare-earth-doped PLZT ceramics, because PLZT can be easily substituted with lanthanide elements for La3+ ions. For this reason, the present studies concern the changes in microstructure and crystal structure as well as in dielectric properties, caused by modification of 8/65/35 PLZT with neodymium dopant. Modification of this material with Nd3+ influences the microstructure, electrooptical and dielectric properties, whereas the changes in crystal structure are slight. It was also observed that the maximum value of dielectric properties decreases and moves to a low temperature. Described changes in physical properties are associated with the significant improvement of relaxor properties, characteristic for pure 8/65/35 PLZT ceramics.

  17. Early tissue response to transscleral neodymium: YAG cyclophotocoagulation.

    PubMed

    Blasini, M; Simmons, R; Shields, M B

    1990-06-01

    Transscleral cyclophotocoagulation was performed with a neodymium: YAG laser on five patients 24-72 hr before enucleation for a blind, painful eye. The thermal mode at 20 ms and a maximum offset between aiming and therapeutic beams were kept constant. Variable parameters evaluated were energy levels between 2 and 8 J and distance from the limbus of 0.5-3.0 mm. Because of the underlying distortion in three of the eyes, meaningful interpretation by light microscopic evaluation was possible only in the other two. This suggested that the early histologic hallmark of the procedure is similar to that previously observed in human autopsy eyes with ciliary epithelial damage and elevation from underlying tissue. In addition, fibrin and scant inflammatory cells were seen in the space between ciliary epithelium and stroma. Minimal damage was observed in the ciliary muscle. These findings suggest that direct damage to the ciliary epithelium is the most likely mechanism of reduced aqueous production by this cyclodestructive procedure. The findings also support the concept that an anterior placement of approximately 1.0-1.5 mm posterior to the limbus is most likely to damage the ciliary epithelium of the pars plicata.

  18. Phase equilibria in the neodymium-cadmium binary system.

    PubMed

    Skołyszewska-Kühberger, Barbara; Reichmann, Thomas L; Ipser, Herbert

    2014-09-05

    The equilibrium phase diagram of the neodymium-cadmium system has been established by thermal, metallographic and X-ray analysis based on a study of 70 alloys. The system contains three congruently melting intermetallic compounds, i.e. NdCd (1040 °C), NdCd2 (995 °C), Nd11Cd45 (855 °C), and four incongruently melting compounds NdCd3 (860 °C), Nd13Cd58 (740 °C), NdCd6 (655 °C) and NdCd11 (520 °C). Four eutectic reactions are found in this binary system, i.e. at ∼25 at.% Cd and 770 °C, at 58 at.% Cd and 955 °C, at 79 at.% Cd and 850 °C, and very close to pure Cd at 318 °C, as well as one eutectoid reaction at ∼15 at.% Cd and 500 °C. The solid solubility of Nd in Cd is negligible. Dilatometric curves were recorded for three Nd-Cd compositions up to 4 at.% Cd, to accurately determine phase transitions between the solid solutions of Cd in the low- and high-temperature modification of Nd.

  19. Identification of Neodymium in the Apogee H-Band Spectra

    NASA Astrophysics Data System (ADS)

    Hasselquist, Sten; Shetrone, Matthew; Cunha, Katia; Smith, Verne V.; Holtzman, Jon; Lawler, J. E.; Allende Prieto, Carlos; Beers, Timothy C.; Chojnowski, Drew; Fernández-Trincado, J. G.; García-Hernández, D. A.; Hearty, Fred R.; Majewski, Steven R.; Pereira, C. B.; Placco, Vinicius M.; Villanova, Sandro; Zamora, Olga

    2016-12-01

    We present the detection of 10 lines of singly ionized neodymium (Nd ii, Z = 60) in H-band spectra using observations from the SDSS-III Apache Point Observatory Galactic Evolution Experiment (APOGEE) survey. These lines were detected in a metal-poor ([Fe/H] ˜ -1.5), neutron-capture element-enhanced star recently discovered in the APOGEE sample. Using an optical high-resolution spectrum, we derive a Nd abundance for this star using Nd ii lines with precise, laboratory-derived gf values. This optical abundance is used to derive log(gf) values for the H-band lines. We use these lines to rederive Nd ii abundances for two more metal-rich, s-process enhanced stars observed by APOGEE and find that these lines yield consistent Nd ii abundances, confirming the Nd enhancement of these stars. We explore the region of parameter space in the APOGEE sample over which these lines can be used to measure Nd ii abundances. We find that Nd abundances can be reliably derived for ˜18% of the red giants observed by APOGEE. This will result in ˜50,000 Milky Way stars with Nd ii abundances following the conclusion of APOGEE-2, allowing for studies of neutron-capture element abundance distributions across the entire Milky Way.

  20. Transendoscopic neodymium:yttrium aluminum garnet laser irradiation in horses.

    PubMed

    Tate, L P; Sweeney, C L; Cullen, J M; Corbett, W T; Newman, H C; Brown, T C; Ketner, M T

    1989-05-01

    A neodymium:yttrium aluminum garnet (Nd:YAG) laser was used to study effects of applying laser irradiation transendoscopically to the corniculate process of the arytenoid cartilage in horses. Dosimetry was established initially in vitro in 10 corniculate cartilages that were irradiated and examined histologically to determine penetration depths at selected power settings. Eleven horses were given xylazine IV and butorphoral tartrate IV, and their left ventricle and corniculate process were irradiated. Six horses had left laryngeal hemiplegia and were euthanatized and necropsied 14 weeks after laser application and evaluation for upper airway stridor. Endoscopy was performed in the 5 other horses; they were euthanatized and necropsied at selected intervals to characterize the healing process. Healing was by second intention and was complete at 14 weeks. Two horses developed buds of granulation tissue along the laser incision, which resolved after a second laser application. Scar tissue formation resulted in left of midline displacement of the dorsal portion of the right corniculate process. The left ventricle healed without complications and was totally ablated. All horses had inspiratory stridor when exercised 14 weeks after laser irradiation.

  1. Power neodymium-glass amplifier of a repetitively pulsed laser

    NASA Astrophysics Data System (ADS)

    Vinogradov, Aleksandr V.; Gaganov, V. E.; Garanin, Sergey G.; Zhidkov, N. V.; Krotov, V. A.; Martynenko, S. P.; Pozdnyakov, E. V.; Solomatin, I. I.

    2011-11-01

    A neodymium-glass diode-pumped amplifier with a zigzag laser beam propagation through the active medium was elaborated; the amplifier is intended for operation in a repetitively pulsed laser. An amplifier unit with an aperture of 20 × 25 mm and a ~40-cm long active medium was put to a test. The energy of pump radiation amounts to 140 J at a wavelength of 806 nm for a pump duration of 550 μs. The energy parameters of the amplifier were experimentally determined: the small-signal gain per pass ~3.2, the linear gain ~0.031 cm-1 with a nonuniformity of its distribution over the aperture within 15%, the stored energy of 0.16 — 0.21 J cm-3. The wavefront distortions in the zigzag laser-beam propagation through the active element of the amplifier did not exceed 0.4λ (λ = 0.63 μm is the probing radiation wavelength).

  2. Dielectric and impedance spectroscopic studies of neodymium gallate

    NASA Astrophysics Data System (ADS)

    Sakhya, Anup Pradhan; Dutta, Alo; Sinha, T. P.

    2016-05-01

    The AC electrical properties of a polycrystalline neodymium gallate, NdGaO3 (NGO), synthesized by the sol-gel method have been investigated by employing impedance spectroscopy in the frequency range from 42 Hz to 5 MHz and in the temperature range from 323 K to 593 K. The X-ray diffraction analysis shows that the compound crystallizes in the orthorhombic phase with Pbnm space group at room temperature. Two relaxation processes with different relaxation times are observed from the impedance as well as modulus spectroscopic measurements, which have been attributed to the grain and the grain boundary effects at different temperatures in NGO. The complex impedance data are analyzed by an electrical equivalent circuit consisting of a resistance and a constant phase element in parallel. It has been observed that the value of the capacitance and the resistance associated with the grain boundary is higher than those associated with the grain. The temperature dependent electrical conductivity shows the negative temperature coefficient of resistance. The frequency dependent conductivity spectra are found to follow the power law.

  3. Accidental macular hole following neodymium:YAG posterior capsulotomy.

    PubMed

    Munteanu, Mihnea; Petrović, Zarko; Stanca, Horia; Rosca, Cosmin; Jianu, Adelina; Boruga, Ovidiu

    2014-01-01

    Posterior capsular opacification (PCO) is the commonest complication of cataract surgery, occurring in up to one-third of patients in a period of five years. The treatment of choice is the Neodymium:YAG laser posterior capsulotomy. This treatment can be associated with several complications, some of them severe. A rare complication of this procedure is the accidental induced macular hole. A 54-year-old female patient was referred to our Department because of a severe loss of vision and a central scotoma at the right eye. The patient underwent a Nd:YAG posterior capsulotomy 2 days ago, for a PCO. The fundus examination at presentation revealed a round retinal defect in the macular region, a massive inferior preretinal hemorrhage and a mild vitreous hamorrhage. A 6-months follow-up of the case, including retinography and fluorescein angiography, is presented. Although the Nd:YAG laser capsulotomy is a safe, noninvasive, and effective outpatient procedure to improve vision hindered by PCO, it must be recognized that it carries a low but definite risk of serious complications. Physicians and patients should be aware of these rare but severe complications regarding this otherwise safe procedure. Fortunately, most of the complications related to this procedure are transient and can be managed by proper medication.

  4. Dielectric and impedance behavior of neodymium substituted strontium hexaferrite

    NASA Astrophysics Data System (ADS)

    Bhat, Bilal Hamid; Samad, Rubiya; Want, Basharat

    2016-09-01

    In this study, dielectric behavior and complex impedance of neodymium (Nd) substituted strontium hexaferrite system: Sr1- x Nd x Fe12O19 ( x = 0.0, 0.05, 0.1, 0.15, 0. 20), synthesized by citrate precursor technique, have been evaluated as a function of applied frequency and temperature. Variation of dielectric constant and dielectric loss with frequency shows the identical behavior for all the compositions. The value of dielectric constant increases with Nd doping. Relaxation process is observed in the composition x = 0.20, and the peaks in this composition shift toward the higher-frequency region as the temperature increases. The dielectric constants show temperature-independent behavior at low temperature, whereas at higher temperatures it increases for all the frequencies. The AC conductivity follows Jonscher's power law, showing that conduction mechanism is due to polaron hopping. Complex impedance as a function of composition and temperature is used to examine the role of grain and grain boundary in the prepared material. Cole-cole plot shows only one semicircle up to x = 0.15, while as for x = 0.20 two semicircles are observed. The conduction mechanism is explained on the basis of both grain and grain boundary.

  5. Laboratory and clinical experience with neodymium:YAG laser prostatectomy

    NASA Astrophysics Data System (ADS)

    Kabalin, John N.

    1996-05-01

    Since 1991, we have undertaken extensive laboratory and clinical studies of the Neodymium:YAG (Nd:YAG) laser for surgical treatment of bladder outlet obstruction due to prostatic enlargement or benign prostatic hyperplasia (BPH). Side-firing optical fibers which emit a divergent, relatively low energy density Nd:YAG laser beam produce coagulation necrosis of obstructing periurethral prostate tissue, followed by gradual dissolution and slough in the urinary stream. Laser-tissue interactions and Nd:YAG laser dosimetry for prostatectomy have been studied in canine and human prostate model systems, enhancing clinical application. Ongoing studies examine comparative Nd:YAG laser dosimetry for various beam configurations produced by available side-firing optical fibers and continue to refine operative technique. We have documented clinical outcomes of Nd:YAG laser prostatectomy in 230 consecutive patients treated with the UrolaseTM side-firing optical fiber. Nd:YAG laser coagulation the prostate produces a remarkably low acute morbidity profile, with no significant bleeding or fluid absorption. No postoperative incontinence has been produced. Serial assessments of voiding outcomes over more than 3 years of followup show objective and symptomatic improvement following Nd:YAG laser prostatectomy which is comparable to older but more morbid electrosurgical approaches. Nd:YAG laser prostatectomy is a safe, efficacious, durable and cost-effective treatment for BPH.

  6. Nuclear Data Sheets for A = 146

    NASA Astrophysics Data System (ADS)

    Khazov, Yu.; Rodionov, A.; Shulyak, G.

    2016-09-01

    Evaluated nuclear structure and decay data for all nuclei within the A = 146 mass chain are presented. The experimental data are evaluated and best values for level and gamma-ray energies, quantum numbers, lifetimes, gamma-ray intensities, and other nuclear properties are recommended. Inconsistencies and discrepancies that exist in the literature are noted. This work supersedes the earlier evaluation by L.K. Peker, J.K. Tuli (1997Pe22), published in Nuclear Data Sheets82, 187 (1997).

  7. Upregulating miR-146a by physcion reverses multidrug resistance in human chronic myelogenous leukemia K562/ADM cells

    PubMed Central

    Liu, Wenjun; He, Juan; Yang, Yiling; Guo, Qulian; Gao, Fei

    2016-01-01

    The aim of this study was to evaluate the role of miR-146a in the drug resistance of chronic myelogenous leukemia (CML) cells (K562/ADM) and to investigate the reversal effect of physcion, a natural compound, on the multidrug-resistance in CML. Our results showed that miR-146a was significantly downregulated in drug-resistant K562 cells and the overexpression of miR-146a in K562/ADM cells could restore the sensitivity to adriamycin (ADM). In addition, our results showed that the downregulation of miR-146a was associated with increase in CXCR4 expression, which was a direct target of miR-146a. Moreover, our findings also provided experimental evidence that physcion could enhance the anti-proliferative effect of ADM in K562/ADM cells by upregulating miR-146a. In conclusion, this present study showed that miR-146a conferred ADM resistance in CML cells and physcion could improve the sensitivity of K562/ADM cells by enhancing apoptosis via upregulating miR-146a. PMID:27904770

  8. Upregulating miR-146a by physcion reverses multidrug resistance in human chronic myelogenous leukemia K562/ADM cells.

    PubMed

    Liu, Wenjun; He, Juan; Yang, Yiling; Guo, Qulian; Gao, Fei

    2016-01-01

    The aim of this study was to evaluate the role of miR-146a in the drug resistance of chronic myelogenous leukemia (CML) cells (K562/ADM) and to investigate the reversal effect of physcion, a natural compound, on the multidrug-resistance in CML. Our results showed that miR-146a was significantly downregulated in drug-resistant K562 cells and the overexpression of miR-146a in K562/ADM cells could restore the sensitivity to adriamycin (ADM). In addition, our results showed that the downregulation of miR-146a was associated with increase in CXCR4 expression, which was a direct target of miR-146a. Moreover, our findings also provided experimental evidence that physcion could enhance the anti-proliferative effect of ADM in K562/ADM cells by upregulating miR-146a. In conclusion, this present study showed that miR-146a conferred ADM resistance in CML cells and physcion could improve the sensitivity of K562/ADM cells by enhancing apoptosis via upregulating miR-146a.

  9. 21 CFR 146.137 - Frozen orange juice.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 21 Food and Drugs 2 2011-04-01 2011-04-01 false Frozen orange juice. 146.137 Section 146.137 Food... Beverages § 146.137 Frozen orange juice. (a) Frozen orange juice is orange juice as defined in § 146.135, except that it is frozen. (b) The name of the food is “Frozen orange juice”. Such name may be preceded...

  10. 21 CFR 146.137 - Frozen orange juice.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Frozen orange juice. 146.137 Section 146.137 Food... Beverages § 146.137 Frozen orange juice. (a) Frozen orange juice is orange juice as defined in § 146.135, except that it is frozen. (b) The name of the food is “Frozen orange juice”. Such name may be preceded...

  11. 21 CFR 146.137 - Frozen orange juice.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 21 Food and Drugs 2 2014-04-01 2014-04-01 false Frozen orange juice. 146.137 Section 146.137 Food... Beverages § 146.137 Frozen orange juice. (a) Frozen orange juice is orange juice as defined in § 146.135, except that it is frozen. (b) The name of the food is “Frozen orange juice”. Such name may be preceded on...

  12. 21 CFR 146.137 - Frozen orange juice.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 2 2013-04-01 2013-04-01 false Frozen orange juice. 146.137 Section 146.137 Food... Beverages § 146.137 Frozen orange juice. (a) Frozen orange juice is orange juice as defined in § 146.135, except that it is frozen. (b) The name of the food is “Frozen orange juice”. Such name may be preceded on...

  13. 21 CFR 146.137 - Frozen orange juice.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 2 2012-04-01 2012-04-01 false Frozen orange juice. 146.137 Section 146.137 Food... Beverages § 146.137 Frozen orange juice. (a) Frozen orange juice is orange juice as defined in § 146.135, except that it is frozen. (b) The name of the food is “Frozen orange juice”. Such name may be preceded on...

  14. 19 CFR 146.95 - Methods of attribution.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 2 2012-04-01 2012-04-01 false Methods of attribution. 146.95 Section 146.95... TREASURY (CONTINUED) FOREIGN TRADE ZONES Petroleum Refineries in Foreign-Trade Subzones § 146.95 Methods of... operating basis necessary for the producibility attribution method are contained in tables published in T.D...

  15. 12 CFR 146.2 - Procedure; effective date.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 12 Banks and Banking 1 2014-01-01 2014-01-01 false Procedure; effective date. 146.2 Section 146.2 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY FEDERAL MUTUAL SAVINGS ASSOCIATIONS-MERGER, DISSOLUTION, REORGANIZATION, AND CONVERSION § 146.2 Procedure; effective date. (a)...

  16. 12 CFR 146.2 - Procedure; effective date.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 12 Banks and Banking 1 2012-01-01 2012-01-01 false Procedure; effective date. 146.2 Section 146.2 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY FEDERAL MUTUAL SAVINGS ASSOCIATIONS-MERGER, DISSOLUTION, REORGANIZATION, AND CONVERSION § 146.2 Procedure; effective date. (a)...

  17. 12 CFR 146.2 - Procedure; effective date.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 12 Banks and Banking 1 2013-01-01 2013-01-01 false Procedure; effective date. 146.2 Section 146.2 Banks and Banking COMPTROLLER OF THE CURRENCY, DEPARTMENT OF THE TREASURY FEDERAL MUTUAL SAVINGS ASSOCIATIONS-MERGER, DISSOLUTION, REORGANIZATION, AND CONVERSION § 146.2 Procedure; effective date. (a)...

  18. 21 CFR 146.152 - Orange juice with preservative.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 21 Food and Drugs 2 2012-04-01 2012-04-01 false Orange juice with preservative. 146.152 Section... Fruit Juices and Beverages § 146.152 Orange juice with preservative. (a) Orange juice with preservative... of orange juice for manufacturing as provided for in § 146.151, except that a preservative is...

  19. 21 CFR 146.152 - Orange juice with preservative.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 21 Food and Drugs 2 2013-04-01 2013-04-01 false Orange juice with preservative. 146.152 Section... Fruit Juices and Beverages § 146.152 Orange juice with preservative. (a) Orange juice with preservative... of orange juice for manufacturing as provided for in § 146.151, except that a preservative is...

  20. 21 CFR 146.152 - Orange juice with preservative.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Orange juice with preservative. 146.152 Section... Fruit Juices and Beverages § 146.152 Orange juice with preservative. (a) Orange juice with preservative... of orange juice for manufacturing as provided for in § 146.151, except that a preservative is...

  1. 40 CFR 146.2 - Law authorizing these regulations.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 22 2010-07-01 2010-07-01 false Law authorizing these regulations. 146.2 Section 146.2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) UNDERGROUND INJECTION CONTROL PROGRAM: CRITERIA AND STANDARDS General Provisions § 146.2...

  2. 17 CFR 256.146 - Accounts receivable from associate companies.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... associate companies. 256.146 Section 256.146 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) UNIFORM SYSTEM OF ACCOUNTS FOR MUTUAL SERVICE COMPANIES AND SUBSIDIARY SERVICE COMPANIES, PUBLIC UTILITY HOLDING COMPANY ACT OF 1935 3. Current and Accrued Assets § 256.146...

  3. 17 CFR 256.146 - Accounts receivable from associate companies.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... associate companies. 256.146 Section 256.146 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION (CONTINUED) UNIFORM SYSTEM OF ACCOUNTS FOR MUTUAL SERVICE COMPANIES AND SUBSIDIARY SERVICE COMPANIES, PUBLIC UTILITY HOLDING COMPANY ACT OF 1935 3. Current and Accrued Assets § 256.146...

  4. 29 CFR 1910.146 - Permit-required confined spaces.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 5 2010-07-01 2010-07-01 false Permit-required confined spaces. 1910.146 Section 1910.146 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR OCCUPATIONAL SAFETY AND HEALTH STANDARDS General Environmental Controls § 1910.146 Permit-required confined spaces. (a) Scope...

  5. 29 CFR 1910.146 - Permit-required confined spaces.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 5 2011-07-01 2011-07-01 false Permit-required confined spaces. 1910.146 Section 1910.146 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR OCCUPATIONAL SAFETY AND HEALTH STANDARDS General Environmental Controls § 1910.146 Permit-required confined spaces. (a) Scope...

  6. 29 CFR 1910.146 - Permit-required confined spaces.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 5 2012-07-01 2012-07-01 false Permit-required confined spaces. 1910.146 Section 1910.146 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR OCCUPATIONAL SAFETY AND HEALTH STANDARDS General Environmental Controls § 1910.146 Permit-required confined spaces. (a) Scope...

  7. 29 CFR 1910.146 - Permit-required confined spaces.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 5 2014-07-01 2014-07-01 false Permit-required confined spaces. 1910.146 Section 1910.146 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR OCCUPATIONAL SAFETY AND HEALTH STANDARDS General Environmental Controls § 1910.146 Permit-required confined spaces. (a) Scope...

  8. 29 CFR 1910.146 - Permit-required confined spaces.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 5 2013-07-01 2013-07-01 false Permit-required confined spaces. 1910.146 Section 1910.146 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR OCCUPATIONAL SAFETY AND HEALTH STANDARDS General Environmental Controls § 1910.146 Permit-required confined spaces. (a) Scope...

  9. 29 CFR 4.146 - Contract obligations after award, generally.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Contract obligations after award, generally. 4.146 Section 4.146 Labor Office of the Secretary of Labor LABOR STANDARDS FOR FEDERAL SERVICE CONTRACTS Application of the McNamara-O'Hara Service Contract Act Period of Coverage § 4.146 Contract obligations...

  10. 40 CFR 146.2 - Law authorizing these regulations.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 23 2014-07-01 2014-07-01 false Law authorizing these regulations. 146.2 Section 146.2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) UNDERGROUND INJECTION CONTROL PROGRAM: CRITERIA AND STANDARDS General Provisions § 146.2 Law...

  11. 40 CFR 146.2 - Law authorizing these regulations.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 23 2011-07-01 2011-07-01 false Law authorizing these regulations. 146.2 Section 146.2 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) UNDERGROUND INJECTION CONTROL PROGRAM: CRITERIA AND STANDARDS General Provisions § 146.2 Law...

  12. 7 CFR 1703.146 - Submission of applications.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 11 2013-01-01 2013-01-01 false Submission of applications. 1703.146 Section 1703.146 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE RURAL DEVELOPMENT Distance Learning and Telemedicine Loan Program § 1703.146 Submission...

  13. 33 CFR 146.120 - Manning of survival craft.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Manning of survival craft. 146.120 Section 146.120 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES OPERATIONS Manned OCS Facilities § 146.120 Manning of survival craft. The owner, the owner's agent, or the...

  14. 46 CFR 201.146 - Receipt of documents after hearing.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 8 2012-10-01 2012-10-01 false Receipt of documents after hearing. 201.146 Section 201.146 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION POLICY, PRACTICE AND PROCEDURE... (Rule 15) § 201.146 Receipt of documents after hearing. Documents to be submitted for the record after...

  15. 46 CFR 201.146 - Receipt of documents after hearing.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 8 2014-10-01 2014-10-01 false Receipt of documents after hearing. 201.146 Section 201.146 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION POLICY, PRACTICE AND PROCEDURE... (Rule 15) § 201.146 Receipt of documents after hearing. Documents to be submitted for the record after...

  16. 46 CFR 201.146 - Receipt of documents after hearing.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 8 2013-10-01 2013-10-01 false Receipt of documents after hearing. 201.146 Section 201.146 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF TRANSPORTATION POLICY, PRACTICE AND PROCEDURE... (Rule 15) § 201.146 Receipt of documents after hearing. Documents to be submitted for the record after...

  17. 19 CFR 146.51 - Customs control of merchandise.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Customs control of merchandise. 146.51 Section 146.51 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) FOREIGN TRADE ZONES Handling of Merchandise in a Zone § 146.51...

  18. 19 CFR 146.13 - Customs forms and procedures.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Customs forms and procedures. 146.13 Section 146.13 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) FOREIGN TRADE ZONES General Provisions § 146.13 Customs forms and...

  19. 19 CFR 146.39 - Direct delivery procedures.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false Direct delivery procedures. 146.39 Section 146.39... TREASURY (CONTINUED) FOREIGN TRADE ZONES Admission of Merchandise to a Zone § 146.39 Direct delivery procedures. (a) General. This procedure is for delivery of merchandise to a zone without prior...

  20. 19 CFR 146.39 - Direct delivery procedures.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Direct delivery procedures. 146.39 Section 146.39... TREASURY (CONTINUED) FOREIGN TRADE ZONES Admission of Merchandise to a Zone § 146.39 Direct delivery procedures. (a) General. This procedure is for delivery of merchandise to a zone without prior...

  1. 7 CFR 1703.146 - Submission of applications.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 11 2012-01-01 2012-01-01 false Submission of applications. 1703.146 Section 1703.146 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE RURAL DEVELOPMENT Distance Learning and Telemedicine Loan Program § 1703.146 Submission of...

  2. 7 CFR 1703.146 - Submission of applications.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 11 2014-01-01 2014-01-01 false Submission of applications. 1703.146 Section 1703.146 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE RURAL DEVELOPMENT Distance Learning and Telemedicine Loan Program § 1703.146 Submission of...

  3. 42 CFR 433.146 - Rights assigned; assignment method.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Rights assigned; assignment method. 433.146 Section 433.146 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN... Assignment of Rights to Benefits § 433.146 Rights assigned; assignment method. (a) Except as specified...

  4. 34 CFR 668.146 - Criteria for approving tests.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 3 2011-07-01 2011-07-01 false Criteria for approving tests. 668.146 Section 668.146... Administered Tests; Specification of Passing Score; Approval of State Process § 668.146 Criteria for approving tests. (a) Except as provided in § 668.148, the Secretary approves a test under this subpart if— (1) The...

  5. 34 CFR 668.146 - Criteria for approving tests.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 3 2013-07-01 2013-07-01 false Criteria for approving tests. 668.146 Section 668.146... Administered Tests; Specification of Passing Score; Approval of State Process § 668.146 Criteria for approving tests. (a) Except as provided in § 668.148, the Secretary approves a test under this subpart if— (1) The...

  6. 34 CFR 668.146 - Criteria for approving tests.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false Criteria for approving tests. 668.146 Section 668.146... Administered Tests; Specification of Passing Score; Approval of State Process § 668.146 Criteria for approving tests. Except as provided in § 668.143— (a) Except as provided in § 668.148, the Secretary approves a...

  7. 34 CFR 668.146 - Criteria for approving tests.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 3 2014-07-01 2014-07-01 false Criteria for approving tests. 668.146 Section 668.146... Administered Tests; Specification of Passing Score; Approval of State Process § 668.146 Criteria for approving tests. (a) Except as provided in § 668.148, the Secretary approves a test under this subpart if— (1) The...

  8. 34 CFR 668.146 - Criteria for approving tests.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 3 2012-07-01 2012-07-01 false Criteria for approving tests. 668.146 Section 668.146... Administered Tests; Specification of Passing Score; Approval of State Process § 668.146 Criteria for approving tests. (a) Except as provided in § 668.148, the Secretary approves a test under this subpart if— (1) The...

  9. 19 CFR 146.64 - Entry for warehouse.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Entry for warehouse. 146.64 Section 146.64 Customs... (CONTINUED) FOREIGN TRADE ZONES Transfer of Merchandise From a Zone § 146.64 Entry for warehouse. (a) Foreign... status may not be entered for warehouse from a zone. Merchandise in nonprivileged foreign...

  10. 19 CFR 146.14 - Retail trade within a zone.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 19 Customs Duties 2 2012-04-01 2012-04-01 false Retail trade within a zone. 146.14 Section 146.14 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) FOREIGN TRADE ZONES General Provisions § 146.14 Retail trade within a zone. Retail...

  11. 19 CFR 146.14 - Retail trade within a zone.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 19 Customs Duties 2 2013-04-01 2013-04-01 false Retail trade within a zone. 146.14 Section 146.14 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) FOREIGN TRADE ZONES General Provisions § 146.14 Retail trade within a zone. Retail...

  12. 19 CFR 146.14 - Retail trade within a zone.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 19 Customs Duties 2 2014-04-01 2014-04-01 false Retail trade within a zone. 146.14 Section 146.14 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) FOREIGN TRADE ZONES General Provisions § 146.14 Retail trade within a zone. Retail...

  13. 19 CFR 146.14 - Retail trade within a zone.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Retail trade within a zone. 146.14 Section 146.14 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) FOREIGN TRADE ZONES General Provisions § 146.14 Retail trade within a zone. Retail...

  14. 19 CFR 146.14 - Retail trade within a zone.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 19 Customs Duties 2 2011-04-01 2011-04-01 false Retail trade within a zone. 146.14 Section 146.14 Customs Duties U.S. CUSTOMS AND BORDER PROTECTION, DEPARTMENT OF HOMELAND SECURITY; DEPARTMENT OF THE TREASURY (CONTINUED) FOREIGN TRADE ZONES General Provisions § 146.14 Retail trade within a zone. Retail...

  15. 9 CFR 146.8 - Terminology and classification; slaughter plants.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 9 Animals and Animal Products 1 2011-01-01 2011-01-01 false Terminology and classification; slaughter plants. 146.8 Section 146.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE... General Provisions § 146.8 Terminology and classification; slaughter plants. Participating...

  16. 9 CFR 146.7 - Terminology and classification; general.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Terminology and classification; general. 146.7 Section 146.7 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE... General Provisions § 146.7 Terminology and classification; general. The official classification...

  17. 9 CFR 146.8 - Terminology and classification; slaughter plants.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Terminology and classification; slaughter plants. 146.8 Section 146.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE... General Provisions § 146.8 Terminology and classification; slaughter plants. Participating...

  18. 9 CFR 146.8 - Terminology and classification; slaughter plants.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 9 Animals and Animal Products 1 2014-01-01 2014-01-01 false Terminology and classification; slaughter plants. 146.8 Section 146.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE... General Provisions § 146.8 Terminology and classification; slaughter plants. Participating...

  19. 9 CFR 146.8 - Terminology and classification; slaughter plants.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 9 Animals and Animal Products 1 2013-01-01 2013-01-01 false Terminology and classification; slaughter plants. 146.8 Section 146.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE... General Provisions § 146.8 Terminology and classification; slaughter plants. Participating...

  20. 9 CFR 146.8 - Terminology and classification; slaughter plants.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 1 2012-01-01 2012-01-01 false Terminology and classification; slaughter plants. 146.8 Section 146.8 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE... General Provisions § 146.8 Terminology and classification; slaughter plants. Participating...

  1. 33 CFR 146.120 - Manning of survival craft.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Manning of survival craft. 146.120 Section 146.120 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES OPERATIONS Manned OCS Facilities § 146.120 Manning of survival craft. The owner, the owner's agent, or...

  2. 33 CFR 146.120 - Manning of survival craft.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Manning of survival craft. 146.120 Section 146.120 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES OPERATIONS Manned OCS Facilities § 146.120 Manning of survival craft. The owner, the owner's agent, or...

  3. 33 CFR 146.120 - Manning of survival craft.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Manning of survival craft. 146.120 Section 146.120 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES OPERATIONS Manned OCS Facilities § 146.120 Manning of survival craft. The owner, the owner's agent, or...

  4. 33 CFR 146.120 - Manning of survival craft.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Manning of survival craft. 146.120 Section 146.120 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES OPERATIONS Manned OCS Facilities § 146.120 Manning of survival craft. The owner, the owner's agent, or...

  5. 33 CFR 146.10 - Notice of new facilities.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Notice of new facilities. 146.10 Section 146.10 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES OPERATIONS OCS Facilities § 146.10 Notice of new facilities. (a) The...

  6. 33 CFR 146.10 - Notice of new facilities.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 2 2014-07-01 2014-07-01 false Notice of new facilities. 146.10 Section 146.10 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES OPERATIONS OCS Facilities § 146.10 Notice of new facilities. (a) The...

  7. 33 CFR 146.10 - Notice of new facilities.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Notice of new facilities. 146.10 Section 146.10 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OUTER CONTINENTAL SHELF ACTIVITIES OPERATIONS OCS Facilities § 146.10 Notice of new facilities. (a) The...

  8. 34 CFR 300.146 - Responsibility of SEA.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 34 Education 2 2013-07-01 2013-07-01 false Responsibility of SEA. 300.146 Section 300.146... Referred by Public Agencies § 300.146 Responsibility of SEA. Each SEA must ensure that a child with a... the standards that apply to education provided by the SEA and LEAs including the requirements of this...

  9. 34 CFR 300.146 - Responsibility of SEA.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 34 Education 2 2014-07-01 2013-07-01 true Responsibility of SEA. 300.146 Section 300.146 Education... Agencies § 300.146 Responsibility of SEA. Each SEA must ensure that a child with a disability who is placed... apply to education provided by the SEA and LEAs including the requirements of this part, except for...

  10. 34 CFR 300.146 - Responsibility of SEA.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 34 Education 2 2012-07-01 2012-07-01 false Responsibility of SEA. 300.146 Section 300.146... Referred by Public Agencies § 300.146 Responsibility of SEA. Each SEA must ensure that a child with a... the standards that apply to education provided by the SEA and LEAs including the requirements of this...

  11. 22 CFR 146.120 - Transfers of property.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... of the fair market value of the property is not upon such sale or transfer properly accounted for to... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Transfers of property. 146.120 Section 146.120... PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Introduction § 146.120 Transfers of...

  12. 19 CFR 146.83 - Revocation of zone grant.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Revocation of zone grant. 146.83 Section 146.83... TREASURY (CONTINUED) FOREIGN TRADE ZONES Penalties; Suspension; Revocation § 146.83 Revocation of zone.... The procedure for revocation of a grant, the decision of the Board, and appeal is covered by...

  13. 19 CFR 146.63 - Entry for consumption.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 19 Customs Duties 2 2010-04-01 2010-04-01 false Entry for consumption. 146.63 Section 146.63... TREASURY (CONTINUED) FOREIGN TRADE ZONES Transfer of Merchandise From a Zone § 146.63 Entry for consumption... status may be entered for consumption from a zone. (b) Zone-restricted merchandise. Merchandise in a zone...

  14. 27 CFR 28.146 - Disposition of forms.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2014-04-01 2014-04-01 false Disposition of forms. 28.146 Section 28.146 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU... Zone § 28.146 Disposition of forms. On removal of the beer or beer concentrate withdrawn under the...

  15. 7 CFR 762.146 - Other servicing procedures.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 7 2014-01-01 2014-01-01 false Other servicing procedures. 762.146 Section 762.146 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY, DEPARTMENT OF AGRICULTURE SPECIAL PROGRAMS GUARANTEED FARM LOANS § 762.146 Other servicing procedures. (a) Additional...

  16. 45 CFR 146.117 - Special enrollment periods.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 45 Public Welfare 1 2013-10-01 2013-10-01 false Special enrollment periods. 146.117 Section 146.117 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES REQUIREMENTS RELATING TO HEALTH CARE ACCESS..., and Limitations on Preexisting Condition Exclusion Periods § 146.117 Special enrollment periods....

  17. 40 CFR 35.146 - Maintenance of effort.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Maintenance of effort. 35.146 Section 35.146 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Environmental Program Grants Air Pollution Control (section 105) § 35.146...

  18. 40 CFR 35.146 - Maintenance of effort.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 1 2014-07-01 2014-07-01 false Maintenance of effort. 35.146 Section 35.146 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL ASSISTANCE STATE AND LOCAL ASSISTANCE Environmental Program Grants Air Pollution Control (section 105) § 35.146...

  19. 34 CFR 300.146 - Responsibility of SEA.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 34 Education 2 2011-07-01 2010-07-01 true Responsibility of SEA. 300.146 Section 300.146 Education... Agencies § 300.146 Responsibility of SEA. Each SEA must ensure that a child with a disability who is placed... apply to education provided by the SEA and LEAs including the requirements of this part, except for...

  20. 9 CFR 381.146 - Sampling at official establishments.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 9 Animals and Animal Products 2 2012-01-01 2012-01-01 false Sampling at official establishments. 381.146 Section 381.146 Animals and Animal Products FOOD SAFETY AND INSPECTION SERVICE, DEPARTMENT OF... Establishments; Processing Inspection and Other Reinspections; Processing Requirements § 381.146 Sampling at...