Sample records for network computing 04-q1

  1. Computation of Optimal Actuator/Sensor Locations

    DTIC Science & Technology

    2013-12-26

    weighting matrices Q = I and R = 0.01, and a minimum variance LQ-cost (with V = I ), a plot of the L2 norm of the control signal versus actuator...0.1 0.2 0.3 0.4 0.5 0.6 0.7 0.8 0.9 1 0 0.05 0.1 0.15 0.2 0.25 actuator location lin ea r− qu ad ra tic c os t ( re la tiv e) Q = I , R = 100 Q... I , R = 1 Q = I , R = 0.01 Q = I , R = 0.0001 (a) 0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 0.8 0.9 1 0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 0.8 0.9 1 actuator location lin

  2. Discrete-state phasor neural networks

    NASA Astrophysics Data System (ADS)

    Noest, André J.

    1988-08-01

    An associative memory network with local variables assuming one of q equidistant positions on the unit circle (q-state phasors) is introduced, and its recall behavior is solved exactly for any q when the interactions are sparse and asymmetric. Such models can describe natural or artifical networks of (neuro-)biological, chemical, or electronic limit-cycle oscillators with q-fold instead of circular symmetry, or similar optical computing devices using a phase-encoded data representation.

  3. Gene identification for risk of relapse in stage I lung adenocarcinoma patients: a combined methodology of gene expression profiling and computational gene network analysis.

    PubMed

    Ludovini, Vienna; Bianconi, Fortunato; Siggillino, Annamaria; Piobbico, Danilo; Vannucci, Jacopo; Metro, Giulio; Chiari, Rita; Bellezza, Guido; Puma, Francesco; Della Fazia, Maria Agnese; Servillo, Giuseppe; Crinò, Lucio

    2016-05-24

    Risk assessment and treatment choice remains a challenge in early non-small-cell lung cancer (NSCLC). The aim of this study was to identify novel genes involved in the risk of early relapse (ER) compared to no relapse (NR) in resected lung adenocarcinoma (AD) patients using a combination of high throughput technology and computational analysis. We identified 18 patients (n.13 NR and n.5 ER) with stage I AD. Frozen samples of patients in ER, NR and corresponding normal lung (NL) were subjected to Microarray technology and quantitative-PCR (Q-PCR). A gene network computational analysis was performed to select predictive genes. An independent set of 79 ADs stage I samples was used to validate selected genes by Q-PCR.From microarray analysis we selected 50 genes, using the fold change ratio of ER versus NR. They were validated both in pool and individually in patient samples (ER and NR) by Q-PCR. Fourteen increased and 25 decreased genes showed a concordance between two methods. They were used to perform a computational gene network analysis that identified 4 increased (HOXA10, CLCA2, AKR1B10, FABP3) and 6 decreased (SCGB1A1, PGC, TFF1, PSCA, SPRR1B and PRSS1) genes. Moreover, in an independent dataset of ADs samples, we showed that both high FABP3 expression and low SCGB1A1 expression was associated with a worse disease-free survival (DFS).Our results indicate that it is possible to define, through gene expression and computational analysis, a characteristic gene profiling of patients with an increased risk of relapse that may become a tool for patient selection for adjuvant therapy.

  4. Network-Physics (NP) BEC DIGITAL(#)-VULNERABILITY; ``Q-Computing"=Simple-Arithmetic;Modular-Congruences=SignalXNoise PRODUCTS=Clock-model;BEC-Factorization;RANDOM-# Definition;P=/=NP TRIVIAL Proof!!!

    NASA Astrophysics Data System (ADS)

    Pi, E. I.; Siegel, E.

    2010-03-01

    Siegel[AMS Natl.Mtg.(2002)-Abs.973-60-124] digits logarithmic- law inversion to ONLY BEQS BEC:Quanta/Bosons=#: EMP-like SEVERE VULNERABILITY of ONLY #-networks(VS.ANALOG INvulnerability) via Barabasi NP(VS.dynamics[Not.AMS(5/2009)] critique);(so called)``quantum-computing''(QC) = simple-arithmetic (sansdivision);algorithmiccomplexities:INtractibility/UNdecidabi lity/INefficiency/NONcomputability/HARDNESS(so MIScalled) ``noise''-induced-phase-transition(NIT)ACCELERATION:Cook-Levin theorem Reducibility = RG fixed-points; #-Randomness DEFINITION via WHAT? Query(VS. Goldreich[Not.AMS(2002)] How? mea culpa)= ONLY MBCS hot-plasma v #-clumping NON-random BEC; Modular-Arithmetic Congruences = Signal x Noise PRODUCTS = clock-model; NON-Shor[Physica A,341,586(04)]BEC logarithmic-law inversion factorization: Watkins #-theory U statistical- physics); P=/=NP C-S TRIVIAL Proof: Euclid!!! [(So Miscalled) computational-complexity J-O obviation(3 millennia AGO geometry: NO:CC,``CS'';``Feet of Clay!!!'']; Query WHAT?:Definition: (so MIScalled)``complexity''=UTTER-SIMPLICITY!! v COMPLICATEDNESS MEASURE(S).

  5. Interdependent networks - Topological percolation research and application in finance

    NASA Astrophysics Data System (ADS)

    Zhou, Di

    This dissertation covers the two major parts of my Ph.D. research: i) developing a theoretical framework of complex networks and applying simulation and numerical methods to study the robustness of the network system, and ii) applying statistical physics concepts and methods to quantitatively analyze complex systems and applying the theoretical framework to study real-world systems. In part I, we focus on developing theories of interdependent networks as well as building computer simulation models, which includes three parts: 1) We report on the effects of topology on failure propagation for a model system consisting of two interdependent networks. We find that the internal node correlations in each of the networks significantly changes the critical density of failures, which can trigger the total disruption of the two-network system. Specifically, we find that the assortativity within a single network decreases the robustness of the entire system. 2) We study the percolation behavior of two interdependent scale-free (SF) networks under random failure of 1-p fraction of nodes. We find that as the coupling strength q between the two networks reduces from 1 (fully coupled) to 0 (no coupling), there exist two critical coupling strengths q1 and q2 , which separate the behaviors of the giant component as a function of p into three different regions, and for q2 < q < q 1 , we observe a hybrid order phase transition phenomenon. 3) We study the robustness of n interdependent networks with partially support-dependent relationship both analytically and numerically. We study a starlike network of n Erdos-Renyi (ER), SF networks and a looplike network of n ER networks, and we find for starlike networks, their phase transition regions change with n, but for looplike networks the phase regions change with average degree k . In part II, we apply concepts and methods developed in statistical physics to study economic systems. We analyze stock market indices and foreign exchange daily returns for 60 countries over the period of 1999-2012. We build a multi-layer network model based on different correlation measures, and introduce a dynamic network model to simulate and analyze the initializing and spreading of financial crisis. Using different computational approaches and econometric tests, we find atypical behavior of the cross correlations and community formations in the financial networks that we study during the financial crisis of 2008. For example, the overall correlation of stock market increases during crisis while the correlation between stock market and foreign exchange market decreases. The dramatic increase in correlations between a specific nation and other nations may indicate that this nation could trigger a global financial crisis. Specifically, core countries that have higher correlations with other countries and larger Gross Domestic Product (GDP) values spread financial crisis quite effectively, yet some countries with small GDPs like Greece and Cyprus are also effective in propagating systemic risk and spreading global financial crisis.

  6. Network model of human aging: Frailty limits and information measures

    NASA Astrophysics Data System (ADS)

    Farrell, Spencer G.; Mitnitski, Arnold B.; Rockwood, Kenneth; Rutenberg, Andrew D.

    2016-11-01

    Aging is associated with the accumulation of damage throughout a persons life. Individual health can be assessed by the Frailty Index (FI). The FI is calculated simply as the proportion f of accumulated age-related deficits relative to the total, leading to a theoretical maximum of f ≤1 . Observational studies have generally reported a much more stringent bound, with f ≤fmax<1 . The value of fmax in observational studies appears to be nonuniversal, but fmax≈0.7 is often reported. A previously developed network model of individual aging was unable to recover fmax<1 while retaining the other observed phenomenology of increasing f and mortality rates with age. We have developed a computationally accelerated network model that also allows us to tune the scale-free network exponent α . The network exponent α significantly affects the growth of mortality rates with age. However, we are only able to recover fmax by also introducing a deficit sensitivity parameter 1 -q , which is equivalent to a false-negative rate q . Our value of q =0.3 is comparable to finite sensitivities of age-related deficits with respect to mortality that are often reported in the literature. In light of nonzero q , we use mutual information I to provide a nonparametric measure of the predictive value of the FI with respect to individual mortality. We find that I is only modestly degraded by q <1 , and this degradation is mitigated when increasing number of deficits are included in the FI. We also find that the information spectrum, i.e., the mutual information of individual deficits versus connectivity, has an approximately power-law dependence that depends on the network exponent α . Mutual information I is therefore a useful tool for characterizing the network topology of aging populations.

  7. Pragmatically Framed Cross-Situational Noun Learning Using Computational Reinforcement Models

    PubMed Central

    Najnin, Shamima; Banerjee, Bonny

    2018-01-01

    Cross-situational learning and social pragmatic theories are prominent mechanisms for learning word meanings (i.e., word-object pairs). In this paper, the role of reinforcement is investigated for early word-learning by an artificial agent. When exposed to a group of speakers, the agent comes to understand an initial set of vocabulary items belonging to the language used by the group. Both cross-situational learning and social pragmatic theory are taken into account. As social cues, joint attention and prosodic cues in caregiver's speech are considered. During agent-caregiver interaction, the agent selects a word from the caregiver's utterance and learns the relations between that word and the objects in its visual environment. The “novel words to novel objects” language-specific constraint is assumed for computing rewards. The models are learned by maximizing the expected reward using reinforcement learning algorithms [i.e., table-based algorithms: Q-learning, SARSA, SARSA-λ, and neural network-based algorithms: Q-learning for neural network (Q-NN), neural-fitted Q-network (NFQ), and deep Q-network (DQN)]. Neural network-based reinforcement learning models are chosen over table-based models for better generalization and quicker convergence. Simulations are carried out using mother-infant interaction CHILDES dataset for learning word-object pairings. Reinforcement is modeled in two cross-situational learning cases: (1) with joint attention (Attentional models), and (2) with joint attention and prosodic cues (Attentional-prosodic models). Attentional-prosodic models manifest superior performance to Attentional ones for the task of word-learning. The Attentional-prosodic DQN outperforms existing word-learning models for the same task. PMID:29441027

  8. Q-values for P and S waves in Southern Sinai and Southern Gulf of Suez Region, Egypt

    NASA Astrophysics Data System (ADS)

    Mohamed, Gad-Elkareem A.

    2014-05-01

    The quality factor Q has been estimated using spectral amplitudes of P and S waves from earthquakes recorded by the seismic network of the Egyptian National Seismological Network (ENSN) in southern Sinai and southern Gulf of Suez region. The earthquakes recorded at nine stations - DHA, NUB, TR1, TR2, KAT, SH2, GRB, HRG and SFG have been used in this study. The spectral amplitude ratios have been calculated between 2 - 20 Hz and single station spectral ratio method has been applied for this purpose. The results show that the quality factors for both P and S waves (Qp and Qs) increase as a function of frequency according to law the Q = Q0fn. By averaging the estimated Q- Value obtained at all stations we calculated the average attenuation laws: Qp = (13.15± 0.76) f0.95± 0.19 and Qs = (20.05± 0.79) f1.03±0.04 for P and S waves respectively. These relations are useful for the estimation of source parameters of earthquakes and simulation of earthquake strong ground motions. The QS /QP ratio for KAT station is less than 1 at lower frequencies, whereas at HRG and SH2 stations QS /QP ratio is are greater than 1.

  9. Numerical Simulation of Unsteady Blood Flow through Capillary Networks.

    PubMed

    Davis, J M; Pozrikidis, C

    2011-08-01

    A numerical method is implemented for computing unsteady blood flow through a branching capillary network. The evolution of the discharge hematocrit along each capillary segment is computed by integrating in time a one-dimensional convection equation using a finite-difference method. The convection velocity is determined by the local and instantaneous effective capillary blood viscosity, while the tube to discharge hematocrit ratio is deduced from available correlations. Boundary conditions for the discharge hematocrit at divergent bifurcations arise from the partitioning law proposed by Klitzman and Johnson involving a dimensionless exponent, q≥1. When q=1, the cells are partitioned in proportion to the flow rate; as q tends to infinity, the cells are channeled into the branch with the highest flow rate. Simulations are performed for a tree-like, perfectly symmetric or randomly perturbed capillary network with m generations. When the tree involves more than a few generations, a supercritical Hopf bifurcation occurs at a critical value of q, yielding spontaneous self-sustained oscillations in the absence of external forcing. A phase diagram in the m-q plane is presented to establish conditions for unsteady flow, and the effect of various geometrical and physical parameters is examined. For a given network tree order, m, oscillations can be induced for a sufficiently high value of q by increasing the apparent intrinsic viscosity, decreasing the ratio of the vessel diameter from one generation to the next, or by decreasing the diameter of the terminal vessels. With other parameters fixed, oscillations are inhibited by increasing m. The results of the continuum model are in excellent agreement with the predictions of a discrete model where the motion of individual cells is followed from inlet to outlet.

  10. Neural network modeling of a dolphin's sonar discrimination capabilities.

    PubMed

    Au, W W; Andersen, L N; Rasmussen, A R; Roitblat, H L; Nachtigall, P E

    1995-07-01

    The capability of an echolocating dolphin to discriminate differences in the wall thickness of cylinders was previously modeled by a counterpropagation neural network using only spectral information from the echoes. In this study, both time and frequency information were used to model the dolphin discrimination capabilities. Echoes from the same cylinders were digitized using a broadband simulated dolphin sonar signal with the transducer mounted on the dolphin's pen. The echoes were filtered by a bank of continuous constant-Q digital filters and the energy from each filter was computed in time increments of 1/bandwidth. Echo features of the standard and each comparison target were analyzed in pairs by a counterpropagation neural network, a backpropagation neural network, and a model using Euclidean distance measures. The backpropagation network performed better than both the counterpropagation network, and the Euclidean model, using either spectral-only features or combined temporal and spectral features. All models performed better using features containing both temporal and spectral information. The backpropagation network was able to perform better than the dolphins for noise-free echoes with Q values as low as 2 and 3. For a Q of 2, only temporal information was available. However, with noisy data, the network required a Q of 8 in order to perform as well as the dolphin.

  11. 26 CFR 1.408(q)-1 - Deemed IRAs in qualified employer plans.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 5 2013-04-01 2013-04-01 false Deemed IRAs in qualified employer plans. 1.408(q)-1 Section 1.408(q)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY.... § 1.408(q)-1 Deemed IRAs in qualified employer plans. (a) In general. Under section 408(q), a...

  12. 26 CFR 1.408(q)-1 - Deemed IRAs in qualified employer plans.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 5 2014-04-01 2014-04-01 false Deemed IRAs in qualified employer plans. 1.408(q)-1 Section 1.408(q)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY.... § 1.408(q)-1 Deemed IRAs in qualified employer plans. (a) In general. Under section 408(q), a...

  13. 26 CFR 1.408(q)-1 - Deemed IRAs in qualified employer plans.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 5 2012-04-01 2011-04-01 true Deemed IRAs in qualified employer plans. 1.408(q)-1 Section 1.408(q)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY.... § 1.408(q)-1 Deemed IRAs in qualified employer plans. (a) In general. Under section 408(q), a...

  14. Multimodal investigation of triple network connectivity in patients with 22q11DS and association with executive functions.

    PubMed

    Padula, Maria C; Schaer, Marie; Scariati, Elisa; Maeder, Johanna; Schneider, Maude; Eliez, Stephan

    2017-04-01

    Large-scale brain networks play a prominent role in cognitive abilities and their activity is impaired in psychiatric disorders, such as schizophrenia. Patients with 22q11.2 deletion syndrome (22q11DS) are at high risk of developing schizophrenia and present similar cognitive impairments, including executive functions deficits. Thus, 22q11DS represents a model for the study of neural biomarkers associated with schizophrenia. In this study, we investigated structural and functional connectivity within and between the Default Mode (DMN), the Central Executive (CEN), and the Saliency network (SN) in 22q11DS using resting-state fMRI and DTI. Furthermore, we investigated if triple network impairments were related to executive dysfunctions or the presence of psychotic symptoms. Sixty-three patients with 22q11DS and sixty-eighty controls (age 6-33 years) were included in the study. Structural connectivity between main nodes of DMN, CEN, and SN was computed using probabilistic tractography. Functional connectivity was computed as the partial correlation between the time courses extracted from each node. Structural and functional connectivity measures were then correlated to executive functions and psychotic symptom scores. Our results showed mainly reduced structural connectivity within the CEN, DMN, and SN, in patients with 22q11DS compared with controls as well as reduced between-network connectivity. Functional connectivity appeared to be more preserved, with impairments being evident only within the DMN. Structural connectivity impairments were also related to executive dysfunctions. These findings show an association between triple network structural alterations and executive deficits in patients with the microdeletion, suggesting that 22q11DS and schizophrenia share common psychopathological mechanisms. Hum Brain Mapp 38:2177-2189, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  15. 26 CFR 1.414(q)-1 - Highly compensated employee.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 5 2012-04-01 2011-04-01 true Highly compensated employee. 1.414(q)-1 Section 1.414(q)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Pension, Profit-Sharing, Stock Bonus Plans, Etc. § 1.414(q)-1 Highly...

  16. 26 CFR 1.414(q)-1 - Highly compensated employee.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 5 2014-04-01 2014-04-01 false Highly compensated employee. 1.414(q)-1 Section 1.414(q)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Pension, Profit-Sharing, Stock Bonus Plans, Etc. § 1.414(q)-1...

  17. 26 CFR 1.414(q)-1 - Highly compensated employee.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 5 2013-04-01 2013-04-01 false Highly compensated employee. 1.414(q)-1 Section 1.414(q)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Pension, Profit-Sharing, Stock Bonus Plans, Etc. § 1.414(q)-1...

  18. 26 CFR 1.414(q)-1 - Highly compensated employee.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 5 2011-04-01 2011-04-01 false Highly compensated employee. 1.414(q)-1 Section 1.414(q)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Pension, Profit-Sharing, Stock Bonus Plans, Etc. § 1.414(q)-1...

  19. 26 CFR 1.414(q)-1 - Highly compensated employee.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 5 2010-04-01 2010-04-01 false Highly compensated employee. 1.414(q)-1 Section 1.414(q)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Pension, Profit-Sharing, Stock Bonus Plans, Etc. § 1.414(q)-1 Highly...

  20. Memristive Computational Architecture of an Echo State Network for Real-Time Speech Emotion Recognition

    DTIC Science & Technology

    2015-05-28

    recognition is simpler and requires less computational resources compared to other inputs such as facial expressions . The Berlin database of Emotional ...Processing Magazine, IEEE, vol. 18, no. 1, pp. 32– 80, 2001. [15] K. R. Scherer, T. Johnstone, and G. Klasmeyer, “Vocal expression of emotion ...Network for Real-Time Speech- Emotion Recognition 5a. CONTRACT NUMBER IN-HOUSE 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 62788F 6. AUTHOR(S) Q

  1. Network-based analysis of oligodendrogliomas predicts novel cancer gene candidates within the region of the 1p/19q co-deletion.

    PubMed

    Gladitz, Josef; Klink, Barbara; Seifert, Michael

    2018-06-11

    Oligodendrogliomas are primary human brain tumors with a characteristic 1p/19q co-deletion of important prognostic relevance, but little is known about the pathology of this chromosomal mutation. We developed a network-based approach to identify novel cancer gene candidates in the region of the 1p/19q co-deletion. Gene regulatory networks were learned from gene expression and copy number data of 178 oligodendrogliomas and further used to quantify putative impacts of differentially expressed genes of the 1p/19q region on cancer-relevant pathways. We predicted 8 genes with strong impact on signaling pathways and 14 genes with strong impact on metabolic pathways widespread across the region of the 1p/19 co-deletion. Many of these candidates (e.g. ELTD1, SDHB, SEPW1, SLC17A7, SZRD1, THAP3, ZBTB17) are likely to push, whereas others (e.g. CAP1, HBXIP, KLK6, PARK7, PTAFR) might counteract oligodendroglioma development. For example, ELTD1, a functionally validated glioblastoma oncogene located on 1p, was overexpressed. Further, the known glioblastoma tumor suppressor SLC17A7 located on 19q was underexpressed. Moreover, known epigenetic alterations triggered by mutated SDHB in paragangliomas suggest that underexpressed SDHB in oligodendrogliomas may support and possibly enhance the epigenetic reprogramming induced by the IDH-mutation. We further analyzed rarely observed deletions and duplications of chromosomal arms within oligodendroglioma subcohorts identifying putative oncogenes and tumor suppressors that possibly influence the development of oligodendroglioma subgroups. Our in-depth computational study contributes to a better understanding of the pathology of the 1p/19q co-deletion and other chromosomal arm mutations. This might open opportunities for functional validations and new therapeutic strategies.

  2. 26 CFR 31.3121(q)-1 - Tips included for employee taxes.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 15 2014-04-01 2014-04-01 false Tips included for employee taxes. 31.3121(q)-1 Section 31.3121(q)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED... § 31.3121(q)-1 Tips included for employee taxes. (a) In general. Except as otherwise provided in...

  3. 26 CFR 31.3121(q)-1 - Tips included for employee taxes.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 15 2011-04-01 2011-04-01 false Tips included for employee taxes. 31.3121(q)-1 Section 31.3121(q)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED... § 31.3121(q)-1 Tips included for employee taxes. (a) In general. Except as otherwise provided in...

  4. 26 CFR 31.3121(q)-1 - Tips included for employee taxes.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 15 2012-04-01 2012-04-01 false Tips included for employee taxes. 31.3121(q)-1 Section 31.3121(q)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED... § 31.3121(q)-1 Tips included for employee taxes. (a) In general. Except as otherwise provided in...

  5. 26 CFR 31.3121(q)-1 - Tips included for employee taxes.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 15 2013-04-01 2013-04-01 false Tips included for employee taxes. 31.3121(q)-1 Section 31.3121(q)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED... § 31.3121(q)-1 Tips included for employee taxes. (a) In general. Except as otherwise provided in...

  6. Detection of CCNE1/URI (19q12) amplification by in situ hybridisation is common in high grade and type II endometrial cancer

    PubMed Central

    Noske, Aurelia; Brandt, Simone; Valtcheva, Nadejda; Wagner, Ulrich; Zhong, Qing; Bellini, Elisa; Fink, Daniel; Obermann, Ellen C.; Moch, Holger; Wild, Peter J.

    2017-01-01

    One TCGA subgroup of endometrial cancer (EC) is characterised by extensive genomic DNA copy number alterations. CCNE1 located at 19q12 is frequently amplified in EC and a target for anti-cancer therapy. The relevance of URI, also located at 19q12, is unknown. To evaluate the prevalence of 19q12 (CCNE1/URI) in EC, we investigated different histologic types by in situ hybridisation (ISH) and copy number assay. We applied a previously established 19q12 ISH for the detection of CCNE1/URI copy numbers in EC (n = 270) using conventional bright field microscopy. In a subset (n = 21), 19q12 amplification status was validated by OncoScan assay. Manual ISH was controlled by a recently developed computational ISHProfiler algorithm. Associations of 19q12 status with Cyclin E1, URI and p53 expression, and clinico-pathological parameters were tested. Amplification of 19q12 (CCNE1/URI) was found in 10.4% (28/270) and was significantly associated with type II EC (high grade and non-endometrioid; p < 0.0001), advanced FIGO stage (p = 0.001), high Cyclin E1 expression (p = 0.008) and aberrant p53 expression (p = 0.04). 19q12 ISH data were confirmed by OncoScan and computational ISHProfiler techniques. The 19q12 in situ hybridisation is a feasible and robust biomarker assay in molecular pathology. Amplification of CCNE1/URI predominantly occurred in type II endometrial cancer. Prospective clinical trials are warranted to assess the utility of combined 19q12 amplification and Cyclin E1/URI protein expression analysis for the prediction of therapeutic response to chemotherapy and/or cyclin-dependent kinase inhibitors in patients with endometrial cancer. PMID:27582547

  7. Algorithm Development of a Telephone Signal Conditioner for the Wideband Integrated Network.

    DTIC Science & Technology

    1981-12-31

    Fig. 25c presents the smoothI I ~~~- -. !... " -.... . . 89 -4 C 0 4.) -41 41 04 4) 4.) 04 r4 90 ., 0 .4) 4J 4.) > :$- 91 4-4 44 󈧭 4-4 󈧰J 44 04 N &Q...Channel Estimation May 25, 1979 4. John D. Markel, Steven B. Davis, and Ted Applebaum A Methodology for Studying Telephone Amplitude Distortion Effects

  8. All Prime Contract Awards by State or Country, Place and Contractor. Part 5. (Adobe, Colorado-Washington, DC)

    DTIC Science & Technology

    1989-01-01

    U000000004000 0 4.001000000000 I- ft I COW Is f00 L00CO LOC Looooooooooo L0 O O OO O O 0 mf :4 Ir rr r or- ft fCl) I4 r’.4. I-- P. I.-4 -4 P P4’ P P0... LOC L o L&-oca L00 L00 L0 L0 LO O1- N1 ).3 - a00 N V 04 04 0-4 04444l- 044q 0-*- 04t 0-0 04W 0 I-N C. 3004 Na e L O C Q L LO LO0 . L0 NI3004 Nt Ŕ = mo... LOC La ) La)C N 1 a-4N< Nt 0-4 0 4 4 .4 I 040 0-4 *to 0-4 000( 00 0a) Nt 1 0- A4c N " N -j- 4d.q- 4- 41- -I-I "IN -to Ř.4 -4 -4111 -4-4 -4N 0 1 Q0

  9. Lateral variation of seismic attenuation in Sikkim Himalaya

    NASA Astrophysics Data System (ADS)

    Thirunavukarasu, Ajaay; Kumar, Ajay; Mitra, Supriyo

    2017-01-01

    We use data from local earthquakes (mb ≥ 3.0) recorded by the Sikkim broad-band seismograph network to study the frequency-dependent attenuation of the crust and uppermost mantle. These events have been relocated using body wave phase data from local and regional seismograms. The decay of coda amplitudes at a range of central frequencies (1 to 12 Hz) has been measured for 74 earthquake-receiver pairs. These measurements are combined to estimate the frequency-dependent coda Q of the form Q( f) = Q0 f η. The estimated Q0 values range from 80 to 200, with an average of 123 ± 29; and η ranges from 0.92 to 1.04, with an average of 0.98 ± 0.04. To study the lateral variation of Q0 and η, we regionalized the measured Q values by combining all the earthquake-receiver path measurements through a back projection algorithm. We consider a single back-scatter model for the coda waves with elliptical sampling and parametrize the sampled area using 0.2° square grids. A nine-point spatial smoothening (similar to spatial Gaussian filter) is applied to stabilize the inversion. This is done at every frequency to observe the spatial variation of Q( f) and subsequently combined to obtain η variations. Results of our study reveal that the Sikkim Himalaya is characterized by low Q0 (80-100) compared to the foreland basin to its south (150-200) and the Nepal Himalaya to its west (140-160). The low Q and high η in Sikkim Himalaya is attributed to extrinsic scattering attenuation from structural heterogeneity and active faults within the crust, and intrinsic attenuation due to anelasticity in the hotter lithosphere beneath the actively deforming mountain belt. Similar low Q and high η values had also been observed in northwest and Garhwal-Kumaun Himalaya.

  10. An Interactive Computer Program for the Preliminary Design and Analysis of Marine Reduction Gears.

    DTIC Science & Technology

    1982-03-01

    4 E-4 c 043 04 4 E- PQ = 24 0 0 E- m 2054 4a =44 Env)2 d0 a b43 09 0 4 I6.4 44 = w. 0k2. . U)3c m 00 I= =C * 4 0 . O)U ad i 0 0~P In3 U= 4 40:M = 4 m...pa *Q4 2 c4~ .~ co N ra a9.* o H 00a = = :b4 H~ H U (3 C) U- of *4= t. E- H)40 UUO *n04 043 q N. W E-4 E-4 1.4-0 31 H 000 oi-4. H4 - M0 2I 2 04 E- HU...aO o %-c ’. %D in0 o f 3W -+V E4pa a noM pa pa pCa 0 pa H14 . pa H 1.4 pa ~00 MtH x 4 -4 U 4E4E4 0 E-4 H E ~ CaM N4 -40 0 UE- E.UE- u 0 c E4 0 9 E-4

  11. Inquiring Minds

    Science.gov Websites

    -performance Computing Grid Computing Networking Mass Storage Plan for the Future State of the Laboratory to help decipher the language of high-energy physics. Virtual Ask-a-Scientist Read transcripts from past online chat sessions. last modified 1/04/2005 email Fermilab Fermi National Accelerator Laboratory

  12. On Functional Module Detection in Metabolic Networks

    PubMed Central

    Koch, Ina; Ackermann, Jörg

    2013-01-01

    Functional modules of metabolic networks are essential for understanding the metabolism of an organism as a whole. With the vast amount of experimental data and the construction of complex and large-scale, often genome-wide, models, the computer-aided identification of functional modules becomes more and more important. Since steady states play a key role in biology, many methods have been developed in that context, for example, elementary flux modes, extreme pathways, transition invariants and place invariants. Metabolic networks can be studied also from the point of view of graph theory, and algorithms for graph decomposition have been applied for the identification of functional modules. A prominent and currently intensively discussed field of methods in graph theory addresses the Q-modularity. In this paper, we recall known concepts of module detection based on the steady-state assumption, focusing on transition-invariants (elementary modes) and their computation as minimal solutions of systems of Diophantine equations. We present the Fourier-Motzkin algorithm in detail. Afterwards, we introduce the Q-modularity as an example for a useful non-steady-state method and its application to metabolic networks. To illustrate and discuss the concepts of invariants and Q-modularity, we apply a part of the central carbon metabolism in potato tubers (Solanum tuberosum) as running example. The intention of the paper is to give a compact presentation of known steady-state concepts from a graph-theoretical viewpoint in the context of network decomposition and reduction and to introduce the application of Q-modularity to metabolic Petri net models. PMID:24958145

  13. The end states of long-period comets and the origin of Halley-type comets

    NASA Astrophysics Data System (ADS)

    Fernández, Julio A.; Gallardo, Tabaré; Young, Juan D.

    2016-09-01

    We analyse a sample of 73 old long-period comets (LPCs) (orbital periods 200 < P < 1000 yr) with perihelion distances q < 2.5 au, discovered in the period 1850-2014. We cloned the observed comets and also added fictitious LPCs with perihelia in the Jupiter's zone. We consider both a purely dynamical evolution and a physico-dynamical one with different physical lifetimes. We can fit the computed energy distribution of comets with q < 1.3 au to the observed one only within the energy range 0.01 < x < 0.04 au-1 (or periods 125 < P < 1000 yr), where the `energy' is taken as the inverse of the semimajor axis a, namely x ≡ 1/a. The best results are obtained for physical lifetimes of about 200-300 revolutions (for a comet with a standard q = 1 au). We find that neither a purely dynamical evolution, nor a physico-dynamical one can reproduce the long tail of larger binding energies (x ≳ 0.04 au-1) that correspond to most Halley-type comets (HTCs) and Jupiter-family comets. We conclude that most HTCs are not the end states of the evolution of LPCs, but come from a different source, a flattened one that we identify with the Centaurs that are scattered to the inner planetary region from the trans-Neptunian belt. These results also show that the boundary between LPCs and HTCs should be located at an energy x ˜ 0.04 au-1 (P ˜ 125 yr), rather than the conventional classical boundary at P = 200 yr.

  14. 18 CFR 357.4 - FERC Form No. 6-Q, Quarterly report of oil pipeline companies.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false FERC Form No. 6-Q... No. 6-Q, Quarterly report of oil pipeline companies. (a) Prescription. The quarterly financial report form of oil pipeline companies, designated as FERC Form No. 6-Q, is prescribed for the reporting...

  15. 18 CFR 357.4 - FERC Form No. 6-Q, Quarterly report of oil pipeline companies.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false FERC Form No. 6-Q... No. 6-Q, Quarterly report of oil pipeline companies. (a) Prescription. The quarterly financial report form of oil pipeline companies, designated as FERC Form No. 6-Q, is prescribed for the reporting...

  16. 18 CFR 357.4 - FERC Form No. 6-Q, Quarterly report of oil pipeline companies.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false FERC Form No. 6-Q... No. 6-Q, Quarterly report of oil pipeline companies. (a) Prescription. The quarterly financial report form of oil pipeline companies, designated as FERC Form No. 6-Q, is prescribed for the reporting...

  17. 18 CFR 357.4 - FERC Form No. 6-Q, Quarterly report of oil pipeline companies.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false FERC Form No. 6-Q... No. 6-Q, Quarterly report of oil pipeline companies. (a) Prescription. The quarterly financial report form of oil pipeline companies, designated as FERC Form No. 6-Q, is prescribed for the reporting...

  18. 18 CFR 357.4 - FERC Form No. 6-Q, Quarterly report of oil pipeline companies.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false FERC Form No. 6-Q... No. 6-Q, Quarterly report of oil pipeline companies. (a) Prescription. The quarterly financial report form of oil pipeline companies, designated as FERC Form No. 6-Q, is prescribed for the reporting...

  19. Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, Fiscal Year 1985. Part 6 (Delaco Supreme Tool & Gear Inc - Electronic Measurements Inc).

    DTIC Science & Technology

    1985-01-01

    itt0D()cu o L CJ L 4P -mo rM1 00 tD )0) 44D um acWnr * t L nŘrm- 40) Ia 4 "NNNN.O Z-4 to 0 WA4 q 4 -4 )) m q 4 Ln M )A(ONc to0 -04 0 0000-4 20 Nl...00000004441 -Q 00 0 0 C9 1 -00000 i wmV-w-w 110qf 0i 04 04C, : 0 wM WO OI * I 00001 - Xi in - X:00 1 .4zI-4o 0 ~ ~ ~ C -4 Q00 Il .I-1 r’.-C 0)) 0kI -- V~I~ El

  20. 26 CFR 1.132-9 - Qualified transportation fringes.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 2 2012-04-01 2012-04-01 false Qualified transportation fringes. 1.132-9... Qualified transportation fringes. (a) Table of contents. This section contains a list of the questions and answers in § 1.132-9. (1) General rules. Q-1. What is a qualified transportation fringe? Q-2. What is...

  1. 26 CFR 1.132-9 - Qualified transportation fringes.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 2 2014-04-01 2014-04-01 false Qualified transportation fringes. 1.132-9... Qualified transportation fringes. (a) Table of contents. This section contains a list of the questions and answers in § 1.132-9. (1) General rules. Q-1. What is a qualified transportation fringe? Q-2. What is...

  2. 26 CFR 1.132-9 - Qualified transportation fringes.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 2 2013-04-01 2013-04-01 false Qualified transportation fringes. 1.132-9... Qualified transportation fringes. (a) Table of contents. This section contains a list of the questions and answers in § 1.132-9. (1) General rules. Q-1. What is a qualified transportation fringe? Q-2. What is...

  3. An Investigation into the Coupling of Interactive and Batch Network Services in Coins.

    DTIC Science & Technology

    1983-06-01

    char. system ex~ td pro.of syszem system exptd time loss use timel time2 lcss 89018 12.24 .120 .610 13.23 8.13 .011 97920 12.75 .130 .600 13.87 8.27...U) 14~4 Hr E-4 3c ft % v% %A 0 3 C in bdd)d~ E- 0 I- * Mw Hn 4b HH "U 04 bbd 04 94O 41waatl Mt -m- - CD E4 0 mpo = oc gm H) 94* 02 P l q3003 M 40 4 04

  4. 18 CFR 141.400 - FERC Form No. 3-Q, Quarterly financial report of electric utilities, licensees, and natural gas...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false FERC Form No. 3-Q... AND REPORTS (SCHEDULES) § 141.400 FERC Form No. 3-Q, Quarterly financial report of electric utilities..., licensees, and natural gas companies, designated as FERC Form No. 3-Q, is prescribed for the reporting...

  5. 18 CFR 141.400 - FERC Form No. 3-Q, Quarterly financial report of electric utilities, licensees, and natural gas...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false FERC Form No. 3-Q... AND REPORTS (SCHEDULES) § 141.400 FERC Form No. 3-Q, Quarterly financial report of electric utilities..., licensees, and natural gas companies, designated as FERC Form No. 3-Q, is prescribed for the reporting...

  6. 18 CFR 141.400 - FERC Form No. 3-Q, Quarterly financial report of electric utilities, licensees, and natural gas...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false FERC Form No. 3-Q... AND REPORTS (SCHEDULES) § 141.400 FERC Form No. 3-Q, Quarterly financial report of electric utilities..., licensees, and natural gas companies, designated as FERC Form No. 3-Q, is prescribed for the reporting...

  7. 18 CFR 141.400 - FERC Form No. 3-Q, Quarterly financial report of electric utilities, licensees, and natural gas...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false FERC Form No. 3-Q... AND REPORTS (SCHEDULES) § 141.400 FERC Form No. 3-Q, Quarterly financial report of electric utilities..., licensees, and natural gas companies, designated as FERC Form No. 3-Q, is prescribed for the reporting...

  8. Short range structure of 0.35Sb2O3-0.65(Li2O-P2O5) glass: A neutron diffraction study

    NASA Astrophysics Data System (ADS)

    Shinde, A. B.; Krishna, P. S. R.

    2018-04-01

    Neutron diffraction studies on Li2O-P2O5 and 0.35Sb2O3-0.65(Li2O-P2O5) glass are performed up to a Qmax of 15 Å-1 on the High-Q diffractometer, Dhruva. MCGR method is used to find pair correlation functions (g(r)) functions from experimentally obtained S(Q). We found that the Li-O and first Sb-O correlations to be around 2.04 Å & 2.15 Å. The O-O correlation from Phosphate & Antimony networks are found to be around 2.7 Å. The short range order of Sb is similar to its crystalline polymorph of valentinite instead of senarmonite. The short range order and network connectivity in this glass implies a structure composed of chains of corner sharing SbO3 pyramidal units connected to PO4 tetrahedra while Li acts as a modifier.

  9. 18 CFR 260.300 - FERC Form No. 3-Q, Quarterly financial report of electric utilities, licensees, and natural gas...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false FERC Form No. 3-Q... ENERGY APPROVED FORMS, NATURAL GAS ACT STATEMENTS AND REPORTS (SCHEDULES) § 260.300 FERC Form No. 3-Q... as FERC Form No. 3-Q, is prescribed for the reporting quarter ending March 31, 2004, and each quarter...

  10. 18 CFR 260.300 - FERC Form No. 3-Q, Quarterly financial report of electric utilities, licensees, and natural gas...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false FERC Form No. 3-Q... ENERGY APPROVED FORMS, NATURAL GAS ACT STATEMENTS AND REPORTS (SCHEDULES) § 260.300 FERC Form No. 3-Q... as FERC Form No. 3-Q, is prescribed for the reporting quarter ending March 31, 2004, and each quarter...

  11. 18 CFR 260.300 - FERC Form No. 3-Q, Quarterly financial report of electric utilities, licensees, and natural gas...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false FERC Form No. 3-Q... ENERGY APPROVED FORMS, NATURAL GAS ACT STATEMENTS AND REPORTS (SCHEDULES) § 260.300 FERC Form No. 3-Q... as FERC Form No. 3-Q, is prescribed for the reporting quarter ending March 31, 2004, and each quarter...

  12. 18 CFR 260.300 - FERC Form No. 3-Q, Quarterly financial report of electric utilities, licensees, and natural gas...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false FERC Form No. 3-Q... ENERGY APPROVED FORMS, NATURAL GAS ACT STATEMENTS AND REPORTS (SCHEDULES) § 260.300 FERC Form No. 3-Q... as FERC Form No. 3-Q, is prescribed for the reporting quarter ending March 31, 2004, and each quarter...

  13. S-wave attenuation in northeastern Sonora, Mexico, near the faults that ruptured during the earthquake of 3 May 1887 Mw 7.5.

    PubMed

    Villalobos-Escobar, Gina P; Castro, Raúl R

    2014-01-01

    We used a new data set of relocated earthquakes recorded by the Seismic Network of Northeastern Sonora, Mexico (RESNES) to characterize the attenuation of S-waves in the fault zone of the 1887 Sonora earthquake (M w 7.5). We determined spectral attenuation functions for hypocentral distances (r) between 10 and 140 km using a nonparametric approach and found that in this fault zone the spectral amplitudes decay slower with distance at low frequencies (f < 4 Hz) compared to those reported in previous studies in the region using more distant recordings. The attenuation functions obtained for 23 frequencies (0.4 ≤ f ≤ 63.1 Hz) permit us estimating the average quality factor Q S  = (141 ± 1.1 )f ((0.74 ± 0.04)) and a geometrical spreading term G(r) = 1/r (0.21). The values of Q estimated for S-wave paths traveling along the fault system that rupture during the 1887 event, in the north-south direction, are considerably lower than the average Q estimated using source-station paths from multiple stations and directions. These results indicate that near the fault zone S waves attenuate considerably more than at regional scale, particularly at low frequencies. This may be the result of strong scattering near the faults due to the fractured upper crust and higher intrinsic attenuation due to stress concentration near the faults.

  14. A New Class of Pulse Compression Codes and Techniques.

    DTIC Science & Technology

    1980-03-26

    04 11 01 12 02 13 03 14 OA DIALFL I NOTE’ BO𔃾T TRANSFORM AND DIGITAL FILTER NETWORK INVERSE TRANSFORM DRIVE FRANK CODE SAME DIGITAL FILTER ; ! ! I I...function from circuit of Fig. I with N =9 TRANSFORM INVERSE TRANSFORM SINGLE _WORD S1A ~b,.ISR -.- ISR I- SR I--~ SR SIC-- I1GENERATOR 0 fJFJ $ J$ .. J...FOR I 1 1 13 11 12 13 FROM RECEIVER TRANSMIT Q- j ~ ~ 01 02 03 0, 02 03 11 01 12 02 13 03 4 1 1 ~ 4 NOTrE: BOTH TRANSFORM ANDI I I I INVERSE TRANSFORM DRIVE

  15. Hot Chips and Hot Interconnects for High End Computing Systems

    NASA Technical Reports Server (NTRS)

    Saini, Subhash

    2005-01-01

    I will discuss several processors: 1. The Cray proprietary processor used in the Cray X1; 2. The IBM Power 3 and Power 4 used in an IBM SP 3 and IBM SP 4 systems; 3. The Intel Itanium and Xeon, used in the SGI Altix systems and clusters respectively; 4. IBM System-on-a-Chip used in IBM BlueGene/L; 5. HP Alpha EV68 processor used in DOE ASCI Q cluster; 6. SPARC64 V processor, which is used in the Fujitsu PRIMEPOWER HPC2500; 7. An NEC proprietary processor, which is used in NEC SX-6/7; 8. Power 4+ processor, which is used in Hitachi SR11000; 9. NEC proprietary processor, which is used in Earth Simulator. The IBM POWER5 and Red Storm Computing Systems will also be discussed. The architectures of these processors will first be presented, followed by interconnection networks and a description of high-end computer systems based on these processors and networks. The performance of various hardware/programming model combinations will then be compared, based on latest NAS Parallel Benchmark results (MPI, OpenMP/HPF and hybrid (MPI + OpenMP). The tutorial will conclude with a discussion of general trends in the field of high performance computing, (quantum computing, DNA computing, cellular engineering, and neural networks).

  16. Status report on the USGS component of the Global Seismographic Network

    NASA Astrophysics Data System (ADS)

    Gee, L. S.; Bolton, H. F.; Derr, J.; Ford, D.; Gyure, G.; Hutt, C. R.; Ringler, A.; Storm, T.; Wilson, D.

    2010-12-01

    As recently as four years ago, the average age of a datalogger in the portion of the Global Seismographic Network (GSN) operated by the United States Geological Survey (USGS) was 16 years - an eternity in the lifetime of computers. The selection of the Q330HR in 2006 as the “next generation” datalogger by an Incorporated Research Institutions for Seismology (IRIS) selection committee opened the door for upgrading the GSN. As part of the “next generation” upgrades, the USGS is replacing a single Q680 system with two Q330HRs and a field processor to provide the same capability. The functionality includes digitizing, timing, event detection, conversion into miniSEED records, archival of miniSEED data on the ASP and telemetry of the miniSEED data using International Deployment of Accelerometers (IDA) Authenticated Disk Protocol (IACP). At many sites, Quanterra Balers are also being deployed. The Q330HRs feature very low power consumption (which will increase reliability) and higher resolution than the Q680 systems. Furthermore, this network-wide upgrade provides the opportunity to correct known station problems, standardize the installation of secondary sensors and accelerometers, replace the feedback electronics of STS-1 sensors, and perform checks of absolute system sensitivity and sensor orientation. The USGS upgrades began with ANMO in May, 2008. Although we deployed Q330s at KNTN and WAKE in the fall of 2007 (and in the installation of the Caribbean network), these deployments did not include the final software configuration for the GSN upgrades. Following this start, the USGS installed six additional sites in FY08. With funding from the American Recovery and Reinvestment Act and the USGS GSN program, 14 stations were upgraded in FY09. Twenty-one stations are expected to be upgraded in FY10. These systematic network-wide upgrades will improve the reliability and data quality of the GSN, with the end goal of providing the Earth science community high quality seismic data with global coverage. The Global Seismographic Network is operated as a partnership among the National Science Foundation, IRIS, IDA, and the USGS.

  17. A Mapping Model for Magnetic Fields with q-profile Variations Typical of Internal Transport Barrier Experiments

    NASA Astrophysics Data System (ADS)

    Rapoport, B. I.; Pavlenko, I.; Weyssow, B.; Carati, D.

    2002-11-01

    Recent studies of ion and electron transport indicate that the safety factor profile, q(r), affects internal transport barrier (ITB) formation in magnetic confinement devices [1, 2]. These studies are consistent with experimental observations that low shear suppresses magnetic island interaction and associated stochasticity when the ITB is formed [3]. In this sense the position and quality of the ITB depend on the stochasticity of the magnetic field, and can be controlled by q(r). This study explores effects of the q-profile on magnetic field stochasticity using two-dimensional mapping techniques. Q-profiles typical of ITB experiments are incorporated into Hamiltonian maps to investigate the relation between magnetic field stochasticity and ITB parameters predicted by other models. It is shown that the mapping technique generates results consistent with these predictions, and suggested that Hamiltonian mappings can be useful as simple and computationally inexpensive approximation methods for describing the magnetic field in ITB experiments. 1. I. Voitsekhovitch et al. 29th EPS Conference on Plasma Physics and Controlled Fusion (2002). O-4.04. 2. G.M.D. Hogeweij et al. Nucl. Fusion. 38 (1998): 1881. 3. K.A. Razumova et al. Plasma Phys. Contr. Fusion. 42 (2000): 973.

  18. Phase Calibration for the Block 1 VLBI System

    NASA Technical Reports Server (NTRS)

    Roth, M. G.; Runge, T. F.

    1983-01-01

    Very Long Baseline Interferometry (VLBI) in the DSN provides support for spacecraft navigation, Earth orientation measurements, and synchronization of network time and frequency standards. An improved method for calibrating instrumental phase shifts has recently been implemented as a computer program in the Block 1 system. The new calibration program, called PRECAL, performs calibrations over intervals as small as 0.4 seconds and greatly reduces the amount of computer processing required to perform phase calibration.

  19. Radar Control Optimal Resource Allocation

    DTIC Science & Technology

    2015-07-13

    other tunable parameters of radars [17, 18]. Such radar resource scheduling usually demands massive computation. Even myopic 14 Distribution A: Approved...reduced validity of the optimal choice of radar resource. In the non- myopic context, the computational problem becomes exponentially more difficult...computed as t? = ασ2 q + σ r √ α q (σ + r + α q) α q2 r − 1ασ q2 + q r2 . (19) We are only interested in t? > 1 and solving the inequality we obtain the

  20. Short-range structure and cation bonding in calcium-aluminum metaphosphate glasses.

    PubMed

    Schneider, J; Oliveira, S L; Nunes, L A O; Bonk, F; Panepucci, H

    2005-01-24

    Comprehension of short- and medium-range order of phosphate glasses is a topic of interest, due to the close relation between network structure and mechanical, thermal, and optical properties. In this work, the short-range structure of glasses (1 - x)Ca(PO(3))(2).xAl(PO(3))(3) with 0 < or = x < or = 0.47 was studied using solid-state nuclear magnetic resonance spectroscopy, Raman spectroscopy, density measurements, and differential scanning calorimetry. The bonding between a network modifier species, Al, and the network forming phosphate groups was probed using high-resolution nuclear magnetic resonance spectroscopy of (27)Al and (31)P. Changes in the compositional behavior of the density, glass transition temperature, PO(2) symmetric vibrations, and Al coordination number were verified at around x = 0.30. (31)P NMR spectra show the presence of phosphorus in Q(2) sites with nonbridging oxygens (NBOs) coordinated by Ca ions and also Q(2) sites with one NBO coordinated by Al (namely, Q(2)(1Al)). The changes in the properties as a function of x can be understood by considering the mean coordination number measured for Al and the formation of only Q(2) and Q(2)(1Al) species. It is possible to calculate that a network formed only by Q(2)(1Al) phosphates can just exist up to the upper limit of x = 0.48. Above this value, Q(2)(2Al) species should appear, imposing a major reorganization of the network. Above x = 0.30 the network undergoes a progressive reorganization to incorporate Al ions, maintaining the condition that only Q(2)(1Al) species are formed. These observations support the idea that bonding principles for cationic species inferred originally in binary phosphate glasses can also be extended to ternary systems.

  1. Evaluating the Limits of Network Topology Inference Via Virtualized Network Emulation

    DTIC Science & Technology

    2015-06-01

    76 xi Figure 5.33 Hop-plot of five best reduction methods. KDD most closely matches the Internet plot...respectively, located around the world. These monitors provide locations from which to perform network measurement experiments, primarily using the ping ...International Symposium on Modeling, Analysis and Simulation of Computer Telecommunication Systems. IEEE, 2001, pp. 346–353. 90 [21] C. Jin , Q. Chen, and S

  2. An Artificial Neural Network Evaluation of Tuberculosis Using Genetic and Physiological Patient Data

    NASA Astrophysics Data System (ADS)

    Griffin, William O.; Hanna, Josh; Razorilova, Svetlana; Kitaev, Mikhael; Alisherov, Avtandiil; Darsey, Jerry A.; Tarasenko, Olga

    2010-04-01

    When doctors see more cases of patients with tell-tale symptoms of a disease, it is hoped that they will be able to recognize an infection administer treatment appropriately, thereby speeding up recovery for sick patients. We hope that our studies can aid in the detection of tuberculosis by using a computer model called an artificial neural network. Our model looks at patients with and without tuberculosis (TB). The data that the neural network examined came from the following: patient' age, gender, place, of birth, blood type, Rhesus (Rh) factor, and genes of the human Leukocyte Antigens (HLA) system (9q34.1) present in the Major Histocompatibility Complex. With availability in genetic data and good research, we hope to give them an advantage in the detection of tuberculosis. We try to mimic the doctor's experience with a computer test, which will learn from patient data the factors that contribute to TB.

  3. Great River Environmental Action Team II. (GREAT II). Upper Mississippi River (Guttenberg, Iowa to Saverton, Missouri). Recreation Work Group. Appendix.

    DTIC Science & Technology

    1980-12-01

    4 1-40 0*r - 04 mr. A-4 A.) 0 00 co 0) r. 4-40 W 1 𔃺Q)0 cc 0 0 .0 0 u 0 U .0 0 0 0 04 0HD 01. 40 A0 1H U) . td p- wu 0c W~ to 0 0.E $U -i 0.4 0w 0...w0 4 0 4) 44 44 0) -4 C: w w . Or,-% 4) ..4 0 ri4 4 w 0 04 1 0-4 " -4 go Q4 v0 0000P 51~N S. C 40 J 0 0 0n v 0 v 0 C -4 )k4 WW0-4 4),- 4bd oo. 4J1 (fl 0

  4. 2005 22nd International Symposium on Ballistics. Volume 3 Thursday - Friday

    DTIC Science & Technology

    2005-11-18

    QinetiQ; Vladimir Titarev, Eleuterio Toro , Umeritek Limited The Mechanism Analysis of Interior Ballistics of Serial Chamber Gun, Dr. Sanjiu Ying, Charge...Elements and Meshless Particles, Gordon R. Johnson and Robert A. Stryk, Network Computing Services, Inc. Experimental and Numerical Study of the...Internal Ballistics Clive R. Woodley, David Finbow, QinetiQ; Vladimir Titarev, Eleuterio Toro , Numeritek Limited 22nd International Symposium on

  5. Evaluation of Predictability of Quartz-Crystal Oscillators and other Devices.

    DTIC Science & Technology

    1981-01-15

    8217-A OZG ,EE D E; " EE D- GIEE GE.;RZE AA 1IA DEGREE ) k- 3ER 3E AZ Or0.(EE I D.Y 0 .Cz Q.U. 0 .03 O.C3 O.35 3.32 3.J4 ).33 033 0.04 Z GAYS O2.C4 0.04...DEGREE DEGREE DEGREE AP.I.A DEGREE DEGREE 3E3RikE OZG EE I OAy 0.01 Q.0b 0.05 0.04 J.04 J.32 0.11k 3.083 3.07 :).13 2CAYS J.cz G.07 0.04 0.05 0.35 Q.32...DEG.REE DEOREE OzG ^EE I DAY 0.01 0.03 0.02 0.02 0.02 .. 02 0.03 0.03 O.JZ 0.03 2 CDYS 0.02 0.0t 0.04 0.03 3.04 0.03 0.34 0.04 0.04 3.05 5 DAY5 O.Ob C.0o

  6. 2005 22nd International Symposium on Ballistics Volume 2 Wednesday

    DTIC Science & Technology

    2005-11-18

    Information 1 Experimental and Numerical Study of the Penetration of Tungsten Carbide Into Steel Targets During High Rates of Strain John F . Moxnes...QinetiQ; Vladimir Titarev, Eleuterio Toro , Umeritek Limited The Mechanism Analysis of Interior Ballistics of Serial Chamber Gun, Dr. Sanjiu Ying, Charge...Elements and Meshless Particles, Gordon R. Johnson and Robert A. Stryk, Network Computing Services, Inc. Experimental and Numerical Study of the

  7. Fat intake and its relationship with pre- and post-menopausal breast cancer risk: a case-control study in Malaysia.

    PubMed

    Sulaiman, Suhaina; Shahril, Mohd Razif; Shaharudin, Soraya Hanie; Emran, Nor Aina; Muhammad, Rohaizak; Ismail, Fuad; Husain, Sharifah Noor Akmal Syed

    2011-01-01

    Fat intake has been shown to play a role in the etiology of breast cancer, but the findings have been inconsistent. To assess the association of premenopausal and postmenopausal breast cancer risk with fat and fat subtypes intake. This is a population based case-control study conducted in Kuala Lumpur, Malaysia from January 2006 to December 2007. Food intake pattern was collected from 382 breast cancer patients and 382 control group via an interviewer-administered food frequency questionnaire. Logistic regression was used to compute odds ratios (OR) with 95% confidence intervals (CI) and a broad range of potential confounders was included in analysis. This study showed that both premenopausal and postmenopausal breast cancer risk did not increase significantly with greater intake of total fat [quartile (Q) 4 versus Q1 OR=0.76, 95% CI, 0.23-2.45 and OR=1.36, 95% CI, 0.30-3.12], saturated fat (ORQ4 to Q1=1.43, 95% CI, 0.51-3.98 and ORQ4 to Q1=1.75, 95% CI, 0.62-3.40), monounsaturated fat (ORQ4 to Q1=0.96, 95% CI, 0.34-1.72 and ORQ4 to Q1=1.74, 95% CI, 0.22-2.79), polyunsaturated fat (ORQ4 to Q1=0.64, 95% CI, 0.23-1.73 and ORQ4 to Q1=0.74, 95% CI, 0.39-1.81), n-3 polyunsaturated fat (ORQ4 to Q1=1.10, 95% CI, 0.49-2.48 and ORQ4 to Q1=0.78, 95% CI, 0.28-2.18), n-6 polyunsaturated fat (ORQ4 to Q1=0.67, 95% CI, 0.24-1.84 and ORQ4 to Q1=0.71, 95% CI, 0.29-1.04) or energy intake (ORQ4 to Q1=1.52, 95% CI, 0.68-3.38 and ORQ4 to Q1=2.21, 95% CI, 0.93-3.36). Total fat and fat subtypes were not associated with pre- and postmenopausal breast cancer risk after controlling for age, other breast cancer risk factors and energy intake. Despite the lack of association, the effects of total fat and fat subtypes intake during premenopausal years towards postmenopausal breast cancer risk still warrant investigation.

  8. Theoretical studies of the potential surface for the F - H2 greater than HF + H reaction

    NASA Technical Reports Server (NTRS)

    Bauschlicher, Charles W., Jr.; Walch, Stephen, P.; Langhoff, Stephen R.; Taylor, Peter R.; Jaffe, Richard L.

    1987-01-01

    The F + H2 yields HF + H potential energy hypersurface was studied in the saddle point and entrance channel regions. Using a large (5s 5p 3d 2f 1g/4s 3p 2d) atomic natural orbital basis set, a classical barrier height of 1.86 kcal/mole was obtained at the CASSCF/multireference CI level (MRCI) after correcting for basis set superposition error and including a Davidson correction (+Q) for higher excitations. Based upon an analysis of the computed results, the true classical barrier is estimated to be about 1.4 kcal/mole. The location of the bottleneck on the lowest vibrationally adiabatic potential curve was also computed and the translational energy threshold determined from a one-dimensional tunneling calculation. Using the difference between the calculated and experimental threshold to adjust the classical barrier height on the computed surface yields a classical barrier in the range of 1.0 to 1.5 kcal/mole. Combining the results of the direct estimates of the classical barrier height with the empirical values obtained from the approximation calculations of the dynamical threshold, it is predicted that the true classical barrier height is 1.4 + or - 0.4 kcal/mole. Arguments are presented in favor of including the relatively large +Q correction obtained when nine electrons are correlated at the CASSCF/MRCI level.

  9. TH-AB-201-09 [Medical Physics, Jun 2016, v. 43(6)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mirzakhanian, L; Benmakhlouf, H; Seuntjens, J

    2016-06-15

    Purpose: To determine the k-(Q-msr,Q)^(f-msr,f-ref ) factor, introduced in the small field formalism for five common type chambers used in the calibration of Leksell Gamma-Knife Perfexion model over a range of different phantom electron densities. Methods: Five chamber types including Exradin-A16, A14SL, A14, A1SL and IBA-CC04 are modeled in EGSnrc and PENELOPE Monte Carlo codes using the blueprints provided by the manufacturers. The chambers are placed in a previously proposed water-filled phantom and four 16-cm diameter spherical phantoms made of liquid water, Solid Water, ABS and polystyrene. Dose to the cavity of the chambers and a small water volume aremore » calculated using EGSnrc/PENELOPE codes. The calculations are performed over a range of phantom electron densities for two chamber orientations. Using the calculated dose-ratio in reference and machine specific reference field, the k-(Q-msr,Q)^(f-msr,f-ref ) factor can be determined. Results: When chambers are placed along the symmetry axis of the collimator block (z-axis), the CC04 requires the smallest correction followed by A1SL and A16. However, when detectors are placed perpendicular to z-axis, A14SL needs the smallest and A16 the largest correction. Moreover, an increase in the phantom electron density results in a linear increase in the k-(Q-msr,Q)^(f-msr,f-ref ). Depending on the chambers, the agreement between this study and a previous study performed varies between 0.05–0.70% for liquid water, 0.07–0.85% for Solid Water and 0.00–0.60% for ABS phantoms. After applying the EGSnrc-calculated k-(Q-msr,Q)^(f-msr,f-ref ) factors for A16 to the previously measured dose-rates in liquid water, Solid Water and ABS normalized to the dose-rate measured with TG-21 protocol and ABS phantom, the dose-rate ratios are found to be 1.004±0.002, 0.996±0.002 and 0.998±0.002 (3σ) respectively. Conclusion: Knowing the electron density of the phantoms, the calculated k-(Q-msr,Q)^(f-msr,f-ref ) values in this work will enable users to apply the appropriate correction for their own specific phantom material. LM acknowledges partial support by the CREATE Medical Physics Research Training Network grant of the Natural Sciences and Engineering Research Council (Grant number: 432290)« less

  10. Exit probability of the one-dimensional q-voter model: Analytical results and simulations for large networks

    NASA Astrophysics Data System (ADS)

    Timpanaro, André M.; Prado, Carmen P. C.

    2014-05-01

    We discuss the exit probability of the one-dimensional q-voter model and present tools to obtain estimates about this probability, both through simulations in large networks (around 107 sites) and analytically in the limit where the network is infinitely large. We argue that the result E(ρ )=ρq/ρq+(1-ρ)q, that was found in three previous works [F. Slanina, K. Sznajd-Weron, and P. Przybyła, Europhys. Lett. 82, 18006 (2008), 10.1209/0295-5075/82/18006; R. Lambiotte and S. Redner, Europhys. Lett. 82, 18007 (2008), 10.1209/0295-5075/82/18007, for the case q =2; and P. Przybyła, K. Sznajd-Weron, and M. Tabiszewski, Phys. Rev. E 84, 031117 (2011), 10.1103/PhysRevE.84.031117, for q >2] using small networks (around 103 sites), is a good approximation, but there are noticeable deviations that appear even for small systems and that do not disappear when the system size is increased (with the notable exception of the case q =2). We also show that, under some simple and intuitive hypotheses, the exit probability must obey the inequality ρq/ρq+(1-ρ)≤E(ρ)≤ρ/ρ +(1-ρ)q in the infinite size limit. We believe this settles in the negative the suggestion made [S. Galam and A. C. R. Martins, Europhys. Lett. 95, 48005 (2001), 10.1209/0295-5075/95/48005] that this result would be a finite size effect, with the exit probability actually being a step function. We also show how the result that the exit probability cannot be a step function can be reconciled with the Galam unified frame, which was also a source of controversy.

  11. Solving the scalability issue in quantum-based refinement: Q|R#1.

    PubMed

    Zheng, Min; Moriarty, Nigel W; Xu, Yanting; Reimers, Jeffrey R; Afonine, Pavel V; Waller, Mark P

    2017-12-01

    Accurately refining biomacromolecules using a quantum-chemical method is challenging because the cost of a quantum-chemical calculation scales approximately as n m , where n is the number of atoms and m (≥3) is based on the quantum method of choice. This fundamental problem means that quantum-chemical calculations become intractable when the size of the system requires more computational resources than are available. In the development of the software package called Q|R, this issue is referred to as Q|R#1. A divide-and-conquer approach has been developed that fragments the atomic model into small manageable pieces in order to solve Q|R#1. Firstly, the atomic model of a crystal structure is analyzed to detect noncovalent interactions between residues, and the results of the analysis are represented as an interaction graph. Secondly, a graph-clustering algorithm is used to partition the interaction graph into a set of clusters in such a way as to minimize disruption to the noncovalent interaction network. Thirdly, the environment surrounding each individual cluster is analyzed and any residue that is interacting with a particular cluster is assigned to the buffer region of that particular cluster. A fragment is defined as a cluster plus its buffer region. The gradients for all atoms from each of the fragments are computed, and only the gradients from each cluster are combined to create the total gradients. A quantum-based refinement is carried out using the total gradients as chemical restraints. In order to validate this interaction graph-based fragmentation approach in Q|R, the entire atomic model of an amyloid cross-β spine crystal structure (PDB entry 2oNA) was refined.

  12. National Dam Inspection Program. Baggaley Dam. (NDI Number PA-00454, PennDER Number-65-10) Ohio River Basin, Indian Camp Run, Westmoreland County, Pennsylvania. Phase I Inspection Report.

    DTIC Science & Technology

    1980-05-01

    o U)q) ) C o ’--I o 2m)U c = 00 -1 a o 4 0 r-4 C 0 o4.) -C)L 0 bo3 0Q) 4 S .) * -ObO -) "a ) - 4C )j 0 04- >4. = M.- Q C) Q) D a al~. 9)C) 4)a ) C)2. Q...Z1 ocacr. . 1 xm j. )( E- 2 9) . ,> ( 1 - - 4C 0 .1a () 4 CZ3 0 = > 0 C E bo to a 4 Lca A3 0- 0 (d 2 0 -4 o 00 (a C-) "-I wz X .4 0 0I X: 0 cc 1) E (UG4...C L (DU) 4)0L r-4 4C ~ ) 0 0 r.1 V 4 LO0U0 0dv 04) 40 V0.0 0 m cC -4 X V 4 c4.) 4.3 3 4) ) -q .) -f .4to V 41 4.) 02 0 C tv 0c c C .4) 0a 0 9) In-4 0

  13. Scalable Quantum Networks for Distributed Computing and Sensing

    DTIC Science & Technology

    2016-04-01

    probabilistic measurement , so we developed quantum memories and guided-wave implementations of same, demonstrating controlled delay of a heralded single...Second, fundamental scalability requires a method to synchronize protocols based on quantum measurements , which are inherently probabilistic. To meet...AFRL-AFOSR-UK-TR-2016-0007 Scalable Quantum Networks for Distributed Computing and Sensing Ian Walmsley THE UNIVERSITY OF OXFORD Final Report 04/01

  14. Word Criticality Analysis. MOS: 67N. Skill Levels 1 & 2

    DTIC Science & Technology

    1981-09-01

    12 1 , lat 0.. 71N 4 1 s,1 󈧅 119 *I .!Ill4 r ITr L34 U., p I*. 1, r-*44,1I6 C. I ", il. TD %T i - 96’ !04- 2,1 -i: l st a64 1104 121! tio 2...14 1’.1 !$04 4:4 11.1* :74 :’~ ~4 te 4 , 4?. 4.. 7 ., !:j-q1 , **)4 1Q3 *2 .1 .~ 4134 . 1.,’ 4- 1 41st -74 Ott. 󈧒 *4 . ,4 4,7Y t 1 46520 n190 37.1

  15. AN ARTIFICIAL NEURAL NETWORK EVALUATION OF TUBERCULOSIS USING GENETIC AND PHYSIOLOGICAL PATIENT DATA

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Griffin, William O.; Darsey, Jerry A.; Hanna, Josh

    When doctors see more cases of patients with tell-tale symptoms of a disease, it is hoped that they will be able to recognize an infection administer treatment appropriately, thereby speeding up recovery for sick patients. We hope that our studies can aid in the detection of tuberculosis by using a computer model called an artificial neural network. Our model looks at patients with and without tuberculosis (TB). The data that the neural network examined came from the following: patient' age, gender, place, of birth, blood type, Rhesus (Rh) factor, and genes of the human Leukocyte Antigens (HLA) system (9q34.1) presentmore » in the Major Histocompatibility Complex. With availability in genetic data and good research, we hope to give them an advantage in the detection of tuberculosis. We try to mimic the doctor's experience with a computer test, which will learn from patient data the factors that contribute to TB.« less

  16. A Quantification of the 3D Modeling Capabilities of the Kinectfusion Algorithm

    DTIC Science & Technology

    2014-03-27

    Based on the documentation, this is based on the idea that the majority GPU cards on the market will not have the memory required to support more than...5.0 4.4 4N 520 7.9 0.4 8.6 8.2 8.0 7.6 6.6 4P 520 6.2 0.3 6.9 6.4 6.2 6.0 5.5 4Q 520 7.1 0.4 8.0 7.3 7.1 6.8 6.1 5D 520 6.4 0.4 7.0 6.6 6.4 6.1 5.5 5N...3Q 5.3 5.3 5.2 -0.1 -1.7% 4D 5.3 5.3 5.2 -0.1 -1.3% 4N 7.9 8.0 7.7 -0.2 -2.2% 4P 6.2 6.2 5.9 -0.3 -5.2% 4Q 7.1 7.1 7.0 -0.1 -1.1% 5D 6.4 6.4 6.6 0.2

  17. Lateral and depth variations of coda Q in the Zagros region of Iran

    NASA Astrophysics Data System (ADS)

    Irandoust, Mohsen Ahmadzadeh; Sobouti, Farhad; Rahimi, Habib

    2016-01-01

    We have analyzed more than 2800 local earthquakes recorded by the Iranian National Seismic Network (INSN) and the Iranian Seismological Center (IRSC) to estimate coda wave quality factor, Q c , in the Zagros fold and thrust belt and the Sanandaj-Sirjan metamorphic zone in Iran. We used the single backscattering model to investigate lateral and depth variations of Q c in the study region. In the interior of Zagros, no strong lateral variation in attenuation parameters is observed. In SE Zagros (the Bandar-Abbas region) where transition to the Makran subduction setting begins, the medium shows lower attenuation. The average frequency relations for the SSZ, the Bandar-Abbas region, and the Zagros are Q c = (124 ± 11) f 0.82 ± 0.04, Q c = (109 ± 2) f 0.99 ± 0.01, and Q c = (85 ± 5) f 1.06 ± 0.03, respectively. To investigate the depth variation of Q c , 18 time windows between 5 and 90 s and at two epicentral distance ranges of R < 100 km and 100 < R < 200 km were considered. It was observed that with increasing coda lapse time, Q 0 ( Q c at 1 Hz) and n (frequency dependence factor) show increasing and decreasing trends, respectively. Beneath the SSZ and at depths of about 50 to 80 km, there is a correlation between the reported low velocity medium and the observed sharp change in the trend of Q 0 and n curves. In comparison with results obtained in other regions of the Iranian plateau, the Zagros along with the Alborz Mountains in the north show highest attenuation of coda wave and strongest frequency dependence, an observation that reflects the intense seismicity and active faulting in these mountain ranges. We also observe a stronger depth dependence of attenuation in the Zagros and SSZ compared to central Iran, indicating a thicker lithosphere in the Zagros region than in central Iran.

  18. Modified creatinine index and risk for cardiovascular events and all-cause mortality in patients undergoing hemodialysis: The Q-Cohort study.

    PubMed

    Arase, Hokuto; Yamada, Shunsuke; Yotsueda, Ryusuke; Taniguchi, Masatomo; Yoshida, Hisako; Tokumoto, Masanori; Nakano, Toshiaki; Tsuruya, Kazuhiko; Kitazono, Takanari

    2018-06-02

    The modified creatinine (Cr) index, calculated by age, sex, pre-dialysis serum Cr levels, and Kt/V for urea, reflects skeletal muscle mass in patients on hemodialysis. Whether the modified Cr index is associated with cardiovascular events and all-cause mortality remains unknown. A total of 3027 patients registered in the Q-Cohort Study, a multicenter, prospective study of patients on hemodialysis in Japan, were analyzed. The main outcomes were cardiovascular events and all-cause mortality. Associations between sex-specific quartiles of the modified Cr index and outcomes were analyzed by the Cox proportional hazard models and the Fine-Gray proportional subdistribution hazards model. The modified Cr index was correlated with known nutritional and inflammatory markers. During a 4-year follow-up, 499 patients died of any cause, 372 experienced heart disease, and 194 developed stroke. The risk for all-cause mortality was significantly higher in the lower quartiles (Q1 and Q2) than in the highest quartile (Q4) as the reference group (hazard ratios and 95% confidence intervals: Q1, 2.65 [1.69-4.25], Q2, 1.92 [1.27-2.94], and Q3, 1.31 [0.87-2.02]). The risk of heart disease was significantly higher in Q1 than in Q4 (hazard ratios and 95% confidence intervals: Q1, 1.64 [1.04-2.61], Q2, 1.34 [0.91-2.00], and Q3, 1.04 [0.71-1.52]). The risk of stroke was not associated with the modified Cr index. A lower modified Cr index is associated with an increased risk for heart disease and all-cause mortality, but not with the risk for stroke in patients on hemodialysis. Copyright © 2018 Elsevier B.V. All rights reserved.

  19. Advantages of measuring the Q Stokes parameter in addition to the total radiance I in the detection of absorbing aerosols

    NASA Astrophysics Data System (ADS)

    Stamnes, Snorre; Fan, Yongzhen; Chen, Nan; Li, Wei; Tanikawa, Tomonori; Lin, Zhenyi; Liu, Xu; Burton, Sharon; Omar, Ali; Stamnes, Jakob J.; Cairns, Brian; Stamnes, Knut

    2018-05-01

    A simple but novel study was conducted to investigate whether an imager-type spectroradiometer instrument like MODIS, currently flying on board the Aqua and Terra satellites, or MERIS, which flew on board Envisat, could detect absorbing aerosols if they could measure the Q Stokes parameter in addition to the total radiance I, that is if they could also measure the linear polarization of the light. Accurate radiative transfer calculations were used to train a fast neural network forward model, which together with a simple statistical optimal estimation scheme was used to retrieve three aerosol parameters: aerosol optical depth at 869 nm, optical depth fraction of fine mode (absorbing) aerosols at 869 nm, and aerosol vertical location. The aerosols were assumed to be bimodal, each with a lognormal size distribution, located either between 0 and 2 km or between 2 and 4 km in the Earth's atmosphere. From simulated data with 3% random Gaussian measurement noise added for each Stokes parameter, it was found that by itself the total radiance I at the nine MODIS VIS channels was generally insufficient to accurately retrieve all three aerosol parameters (˜ 15% to 37% successful), but that together with the Q Stokes component it was possible to retrieve values of aerosol optical depth at 869 nm to ± 0.03, single-scattering albedo at 869 nm to ± 0.04, and vertical location in ˜ 65% of the cases. This proof-of-concept retrieval algorithm uses neural networks to overcome the computational burdens of using vector radiative transfer to accurately simulate top-of-atmosphere (TOA) total and polarized radiances, enabling optimal estimation techniques to exploit information from multiple channels. Therefore such an algorithm could, in concept, be readily implemented for operational retrieval of aerosol and ocean products from moderate or hyperspectral spectroradiometers.

  20. Coenzyme Q10 Supplementation Decreases Statin-Related Mild-to-Moderate Muscle Symptoms: A Randomized Clinical Study

    PubMed Central

    Skarlovnik, Ajda; Janić, Miodrag; Lunder, Mojca; Turk, Martina; Šabovič, Mišo

    2014-01-01

    Background Statin use is frequently associated with muscle-related symptoms. Coenzyme Q10 supplementation has yielded conflicting results in decreasing statin myopathy. Herein, we tested whether coenzyme Q10 supplementation could decrease statin-associated muscular pain in a specific group of patients with mild-to-moderate muscle symptoms. Material/Methods Fifty patients treated with statins and reporting muscle pain were recruited. The Q10 group (n=25) received coenzyme Q10 supplementation over a period of 30 days (50 mg twice daily), and the control group (n=25) received placebo. The Brief Pain Inventory (BPI) questionnaire was used and blood testing was performed at inclusion in the study and after 30 days of supplementation. Results The intensity of muscle pain, measured as the Pain Severity Score (PSS), in the Q10 group was reduced from 3.9±0.4 to 2.9±0.4 (P<0.001). The Pain Interference Score (PIS) after Q10 supplementation was reduced from 4.0±0.4 to 2.6±0.4 (P<0.001). In the placebo group, PSS and PIS did not change. Coenzyme Q10 supplementation decreased statin-related muscle symptoms in 75% of patients. The relative values of PSS and PIS significantly decreased (−33.1% and −40.3%, respectively) in the Q10 group compared to placebo group (both P<0.05). From baseline, no differences in liver and muscle enzymes or cholesterol values were found. Conclusions The present results show that coenzyme Q10 supplementation (50 mg twice daily) effectively reduced statin-related mild-to-moderate muscular symptoms, causing lower interference of statin-related muscular symptoms with daily activities. PMID:25375075

  1. Coenzyme Q10 supplementation decreases statin-related mild-to-moderate muscle symptoms: a randomized clinical study.

    PubMed

    Skarlovnik, Ajda; Janić, Miodrag; Lunder, Mojca; Turk, Martina; Šabovič, Mišo

    2014-11-06

    Statin use is frequently associated with muscle-related symptoms. Coenzyme Q10 supplementation has yielded conflicting results in decreasing statin myopathy. Herein, we tested whether coenzyme Q10 supplementation could decrease statin-associated muscular pain in a specific group of patients with mild-to-moderate muscle symptoms. Fifty patients treated with statins and reporting muscle pain were recruited. The Q10 group (n=25) received coenzyme Q10 supplementation over a period of 30 days (50 mg twice daily), and the control group (n=25) received placebo. The Brief Pain Inventory (BPI) questionnaire was used and blood testing was performed at inclusion in the study and after 30 days of supplementation. The intensity of muscle pain, measured as the Pain Severity Score (PSS), in the Q10 group was reduced from 3.9±0.4 to 2.9±0.4 (P<0.001). The Pain Interference Score (PIS) after Q10 supplementation was reduced from 4.0±0.4 to 2.6±0.4 (P<0.001). In the placebo group, PSS and PIS did not change. Coenzyme Q10 supplementation decreased statin-related muscle symptoms in 75% of patients. The relative values of PSS and PIS significantly decreased (-33.1% and -40.3%, respectively) in the Q10 group compared to placebo group (both P<0.05). From baseline, no differences in liver and muscle enzymes or cholesterol values were found. The present results show that coenzyme Q10 supplementation (50 mg twice daily) effectively reduced statin-related mild-to-moderate muscular symptoms, causing lower interference of statin-related muscular symptoms with daily activities.

  2. Discrete-Time Deterministic $Q$ -Learning: A Novel Convergence Analysis.

    PubMed

    Wei, Qinglai; Lewis, Frank L; Sun, Qiuye; Yan, Pengfei; Song, Ruizhuo

    2017-05-01

    In this paper, a novel discrete-time deterministic Q -learning algorithm is developed. In each iteration of the developed Q -learning algorithm, the iterative Q function is updated for all the state and control spaces, instead of updating for a single state and a single control in traditional Q -learning algorithm. A new convergence criterion is established to guarantee that the iterative Q function converges to the optimum, where the convergence criterion of the learning rates for traditional Q -learning algorithms is simplified. During the convergence analysis, the upper and lower bounds of the iterative Q function are analyzed to obtain the convergence criterion, instead of analyzing the iterative Q function itself. For convenience of analysis, the convergence properties for undiscounted case of the deterministic Q -learning algorithm are first developed. Then, considering the discounted factor, the convergence criterion for the discounted case is established. Neural networks are used to approximate the iterative Q function and compute the iterative control law, respectively, for facilitating the implementation of the deterministic Q -learning algorithm. Finally, simulation results and comparisons are given to illustrate the performance of the developed algorithm.

  3. Mind Your Ps and Qs: The Interrelation between Period (P) and Mass-ratio (Q) Distributions of Binary Stars

    NASA Astrophysics Data System (ADS)

    Moe, Maxwell; Di Stefano, Rosanne

    2017-06-01

    We compile observations of early-type binaries identified via spectroscopy, eclipses, long-baseline interferometry, adaptive optics, common proper motion, etc. Each observational technique is sensitive to companions across a narrow parameter space of orbital periods P and mass ratios q = {M}{comp}/M 1. After combining the samples from the various surveys and correcting for their respective selection effects, we find that the properties of companions to O-type and B-type main-sequence (MS) stars differ among three regimes. First, at short orbital periods P ≲ 20 days (separations a ≲ 0.4 au), the binaries have small eccentricities e ≲ 0.4, favor modest mass ratios < q> ≈ 0.5, and exhibit a small excess of twins q > 0.95. Second, the companion frequency peaks at intermediate periods log P (days) ≈ 3.5 (a ≈ 10 au), where the binaries have mass ratios weighted toward small values q ≈ 0.2-0.3 and follow a Maxwellian “thermal” eccentricity distribution. Finally, companions with long orbital periods log P (days) ≈ 5.5-7.5 (a ≈ 200-5000 au) are outer tertiary components in hierarchical triples and have a mass ratio distribution across q ≈ 0.1-1.0 that is nearly consistent with random pairings drawn from the initial mass function. We discuss these companion distributions and properties in the context of binary-star formation and evolution. We also reanalyze the binary statistics of solar-type MS primaries, taking into account that 30% ± 10% of single-lined spectroscopic binaries likely contain white dwarf companions instead of low-mass stellar secondaries. The mean frequency of stellar companions with q > 0.1 and log P (days) < 8.0 per primary increases from 0.50 ± 0.04 for solar-type MS primaries to 2.1 ± 0.3 for O-type MS primaries. We fit joint probability density functions f({M}1,q,P,e)\

  4. Coenzyme Q(1) as a probe for mitochondrial complex I activity in the intact perfused hyperoxia-exposed wild-type and Nqo1-null mouse lung.

    PubMed

    Bongard, Robert D; Myers, Charles R; Lindemer, Brian J; Baumgardt, Shelley; Gonzalez, Frank J; Merker, Marilyn P

    2012-05-01

    Previous studies showed that coenzyme Q(1) (CoQ(1)) reduction on passage through the rat pulmonary circulation was catalyzed by NAD(P)H:quinone oxidoreductase 1 (NQO1) and mitochondrial complex I, but that NQO1 genotype was not a factor in CoQ(1) reduction on passage through the mouse lung. The aim of the present study was to evaluate the complex I contribution to CoQ(1) reduction in the isolated perfused wild-type (NQO1(+/+)) and Nqo1-null (NQO1(-)/(-)) mouse lung. CoQ(1) reduction was measured as the steady-state pulmonary venous CoQ(1) hydroquinone (CoQ(1)H(2)) efflux rate during infusion of CoQ(1) into the pulmonary arterial inflow. CoQ(1)H(2) efflux rates during infusion of 50 μM CoQ(1) were not significantly different for NQO1(+/+) and NQO1(-/-) lungs (0.80 ± 0.03 and 0.68 ± 0.07 μmol·min(-1)·g lung dry wt(-1), respectively, P > 0.05). The mitochondrial complex I inhibitor rotenone depressed CoQ(1)H(2) efflux rates for both genotypes (0.19 ± 0.08 and 0.08 ± 0.04 μmol·min(-1)·g lung dry wt(-1) for NQO1(+/+) and NQO1(-/-), respectively, P < 0.05). Exposure of mice to 100% O(2) for 48 h also depressed CoQ(1)H(2) efflux rates in NQO1(+/+) and NQO1(-/-) lungs (0.43 ± 0.03 and 0.11 ± 0.04 μmol·min(-1)·g lung dry wt(-1), respectively, P < 0.05 by ANOVA). The impact of rotenone or hyperoxia on CoQ(1) redox metabolism could not be attributed to effects on lung wet-to-dry weight ratios, perfusion pressures, perfused surface areas, or total venous effluent CoQ(1) recoveries, the latter measured by spectrophotometry or mass spectrometry. Complex I activity in mitochondria-enriched lung fractions was depressed in hyperoxia-exposed lungs for both genotypes. This study provides new evidence for the potential utility of CoQ(1) as a nondestructive indicator of the impact of pharmacological or pathological exposures on complex I activity in the intact perfused mouse lung.

  5. Stability-to-instability transition in the structure of large-scale networks

    NASA Astrophysics Data System (ADS)

    Hu, Dandan; Ronhovde, Peter; Nussinov, Zohar

    2012-12-01

    We examine phase transitions between the “easy,” “hard,” and “unsolvable” phases when attempting to identify structure in large complex networks (“community detection”) in the presence of disorder induced by network “noise” (spurious links that obscure structure), heat bath temperature T, and system size N. The partition of a graph into q optimally disjoint subgraphs or “communities” inherently requires Potts-type variables. In earlier work [Philos. Mag.1478-643510.1080/14786435.2011.616547 92, 406 (2012)], when examining power law and other networks (and general associated Potts models), we illustrated that transitions in the computational complexity of the community detection problem typically correspond to spin-glass-type transitions (and transitions to chaotic dynamics in mechanical analogs) at both high and low temperatures and/or noise. The computationally “hard” phase exhibits spin-glass type behavior including memory effects. The region over which the hard phase extends in the noise and temperature phase diagram decreases as N increases while holding the average number of nodes per community fixed. This suggests that in the thermodynamic limit a direct sharp transition may occur between the easy and unsolvable phases. When present, transitions at low temperature or low noise correspond to entropy driven (or “order by disorder”) annealing effects, wherein stability may initially increase as temperature or noise is increased before becoming unsolvable at sufficiently high temperature or noise. Additional transitions between contending viable solutions (such as those at different natural scales) are also possible. Identifying community structure via a dynamical approach where “chaotic-type” transitions were found earlier. The correspondence between the spin-glass-type complexity transitions and transitions into chaos in dynamical analogs might extend to other hard computational problems. In this work, we examine large networks (with a power law distribution in cluster size) that have a large number of communities (q≫1). We infer that large systems at a constant ratio of q to the number of nodes N asymptotically tend towards insolvability in the limit of large N for any positive T. The asymptotic behavior of temperatures below which structure identification might be possible, T×=O[1/lnq], decreases slowly, so for practical system sizes, there remains an accessible, and generally easy, global solvable phase at low temperature. We further employ multivariate Tutte polynomials to show that increasing q emulates increasing T for a general Potts model, leading to a similar stability region at low T. Given the relation between Tutte and Jones polynomials, our results further suggest a link between the above complexity transitions and transitions associated with random knots.

  6. Potts Model in One-Dimension on Directed Small-World Networks

    NASA Astrophysics Data System (ADS)

    Aquino, Édio O.; Lima, F. W. S.; Araújo, Ascânio D.; Costa Filho, Raimundo N.

    2018-06-01

    The critical properties of the Potts model with q=3 and 8 states in one-dimension on directed small-world networks are investigated. This disordered system is simulated by updating it with the Monte Carlo heat bath algorithm. The Potts model on these directed small-world networks presents in fact a second-order phase transition with a new set of critical exponents for q=3 considering a rewiring probability p=0.1. For q=8 the system exhibits only a first-order phase transition independent of p.

  7. Exploring function activated chlorins using MCD spectroscopy and DFT methods: design of a chlorin with a remarkably intense, red Q band.

    PubMed

    Zhang, Angel; Stillman, Martin J

    2018-05-09

    The electronic structures of three previously synthesized Ni-coordinated chlorins with β-substituents of thioketone, fluorene, and ketone were investigated using magnetic circular dichroism spectroscopy (MCD) and density functional theory (DFT) for potential application as sensitizers for dye-sensitized solar cells (DSSCs). Computational studies on modeled Zn-coordinated chlorins allowed identification of charge transfer and d-d transitions of the Ni2+ coordinated chlorins. Two fictive Zn chlorins, M1 and M2, were designed with thiophene units based on the fluorene substituted chlorin. Substitution with thiophene altered the typical arrangement of the four Gouterman molecular orbitals (MOs) and red-shifted and greatly intensified the lowest energy absorption band (the Q band). The introduction of the thiophene-based MO as the LUMO below the usual Gouterman LUMO is predicted to increase the efficiency of electron transfer from the dye to the conduction band of the semiconductor in DSSCs. The addition of a donor group on the opposite pyrrole (M2) red-shifted the Q band further and introduced a donor-based MO between the typical Gouterman HOMO and HOMO-1. Despite the relatively small ΔHOMO, M1 and M2 exhibited remarkably intense Q bands. M2 would be a possible candidate for application in DSSCs due to its panchromatic absorption, intense and red-shifted Q band, and the presence of the substituent based MO properties. Another indicator of a successful dye is the alignment of the ground state and excited state oxidation potentials (GSOP and ESOP, respectively) with respect to the conduction band of the semiconductor. The GSOP for M2 lies 0.55 eV below the I-/I3- redox potential and the ESOP lies 0.48 eV above the TiO2 conduction band. The impact of the thiophene dominance in the LUMO also supports the prediction of efficient sensitization properties. The remarkably intense Q band of M2 predicted to be at 777 nm with a ΔHOMO of just 1.04 eV provides a synthetic route to tetrapyrroles with extremely intense, red Q bands without the need for aza nitrogens of the phthalocyanines. This study illustrates the value of guided synthesis using MCD spectral analysis and computational methods for optimizing the design of porphyrin dyes.

  8. A General Surface Representation Module Designed for Geodesy

    DTIC Science & Technology

    1980-06-01

    one considers as a reasonable interpolation function, one of the often accepted compromises is the choice q = 2 (Schumnaker, 1976, Bybee and Bedross...Fast Fourier Transform: Englewood Cliffs, New Jersey. Bybee , J.E. and G.M. Bedross (1978): The IPIN computer network control softward. In: Proceedings

  9. Analytical expression for the exit probability of the q -voter model in one dimension

    NASA Astrophysics Data System (ADS)

    Timpanaro, André M.; Galam, Serge

    2015-07-01

    We present in this paper an approximation that is able to give an analytical expression for the exit probability of the q -voter model in one dimension. This expression gives a better fit for the more recent data about simulations in large networks [A. M. Timpanaro and C. P. C. do Prado, Phys. Rev. E 89, 052808 (2014), 10.1103/PhysRevE.89.052808] and as such departs from the expression ρ/qρq+(1-ρ ) q found in papers that investigated small networks only [R. Lambiotte and S. Redner, Europhys. Lett. 82, 18007 (2008), 10.1209/0295-5075/82/18007; P. Przybyła et al., Phys. Rev. E 84, 031117 (2011), 10.1103/PhysRevE.84.031117; F. Slanina et al., Europhys. Lett. 82, 18006 (2008), 10.1209/0295-5075/82/18006]. The approximation consists in assuming a large separation on the time scales at which active groups of agents convince inactive ones and the time taken in the competition between active groups. Some interesting findings are that for q =2 we still have ρ/2ρ2+(1-ρ ) 2 as the exit probability and for q >2 we can obtain a lower-order approximation of the form ρ/sρs+(1-ρ ) s with s varying from q for low values of q to q -1/2 for large values of q . As such, this work can also be seen as a deduction for why the exit probability ρ/qρq+(1-ρ ) q gives a good fit, without relying on mean-field arguments or on the assumption that only the first step is nondeterministic, as q and q -1/2 will give very similar results when q →∞ .

  10. Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 13. (Michigan Power Company-Noord Natie S V)

    DTIC Science & Technology

    1989-01-01

    M-4 it 0n no ( nCAo 0 na0 0 noootioInilI r r ALLIn (no0 in-4 (n-4 Oi1lV In M0-4 11O-4 00 00 0 00- 4- 4 4- 4-4-4 -4 -4- - 41-4 -4-444-4 00 00) 0-4 liW...4 -1( a -4 -.10 j 0 0 in 00-4 1100 00. "C)0 004 Q>44Q4000 LA4 44a 0 ON "N (. "U 4110100-4 x110.4 NCAO ) 0) a (1 000N )0 00..)x.a 0.. 0 x 0(0 0( 04X

  11. Self-adaptive trust based ABR protocol for MANETs using Q-learning.

    PubMed

    Kumar, Anitha Vijaya; Jeyapal, Akilandeswari

    2014-01-01

    Mobile ad hoc networks (MANETs) are a collection of mobile nodes with a dynamic topology. MANETs work under scalable conditions for many applications and pose different security challenges. Due to the nomadic nature of nodes, detecting misbehaviour is a complex problem. Nodes also share routing information among the neighbours in order to find the route to the destination. This requires nodes to trust each other. Thus we can state that trust is a key concept in secure routing mechanisms. A number of cryptographic protection techniques based on trust have been proposed. Q-learning is a recently used technique, to achieve adaptive trust in MANETs. In comparison to other machine learning computational intelligence techniques, Q-learning achieves optimal results. Our work focuses on computing a score using Q-learning to weigh the trust of a particular node over associativity based routing (ABR) protocol. Thus secure and stable route is calculated as a weighted average of the trust value of the nodes in the route and associativity ticks ensure the stability of the route. Simulation results show that Q-learning based trust ABR protocol improves packet delivery ratio by 27% and reduces the route selection time by 40% over ABR protocol without trust calculation.

  12. Self-Adaptive Trust Based ABR Protocol for MANETs Using Q-Learning

    PubMed Central

    Jeyapal, Akilandeswari

    2014-01-01

    Mobile ad hoc networks (MANETs) are a collection of mobile nodes with a dynamic topology. MANETs work under scalable conditions for many applications and pose different security challenges. Due to the nomadic nature of nodes, detecting misbehaviour is a complex problem. Nodes also share routing information among the neighbours in order to find the route to the destination. This requires nodes to trust each other. Thus we can state that trust is a key concept in secure routing mechanisms. A number of cryptographic protection techniques based on trust have been proposed. Q-learning is a recently used technique, to achieve adaptive trust in MANETs. In comparison to other machine learning computational intelligence techniques, Q-learning achieves optimal results. Our work focuses on computing a score using Q-learning to weigh the trust of a particular node over associativity based routing (ABR) protocol. Thus secure and stable route is calculated as a weighted average of the trust value of the nodes in the route and associativity ticks ensure the stability of the route. Simulation results show that Q-learning based trust ABR protocol improves packet delivery ratio by 27% and reduces the route selection time by 40% over ABR protocol without trust calculation. PMID:25254243

  13. Extension of high poloidal beta scenario in DIII-D to lower q95 for steady state fusion reactor

    NASA Astrophysics Data System (ADS)

    Huang, J.; Gong, X.; Qian, J.; Ding, S.; Ren, Q.; Guo, W.; Pan, C.; Li, G.; Xia, T.; Garofalo, A.; Lao, L.; Hyatt, A.; Ferron, J.; Collins, C.; Lin, D.; McKee, G.; Rhode, T.; McClenaghan, J.; Holcomb, C.; Cui, L.; Heidbrink, W.; Zhu, Y.; Diiid Team; East Team

    2017-10-01

    DIII-D/EAST joint experiments have improved the high poloidal beta scenario with sustained large-radius internal transport barrier (ITB) extended to high plasma current Ip 1MA with q95 6.0. Slight off-axis NBCD is applied to obtain broader current density profile, ITBs can now be sustained below the previously observed βp threshold with excellent confinement (H98y2 1.8). The scenario also exhibits a local negative shear appearing with q increased at rho 0.4, which helps ITB formation and sustainment. This confirms TGLF prediction that negative magnetic shear can help recover ITB and achieve high confinement with reduced q95. Detailed analysis shows that the Shafranov shift and q profile is critical in the ITB formation at high βp regime. Supported in part by National Magnetic Confinement Fusion Program of China 2015GB102000, 2015GB110005, and US Department of Energy under DE-FC02-04ER54698.

  14. Non-equilibrium fluctuations of a semi-flexible filament driven by active cross-linkers

    NASA Astrophysics Data System (ADS)

    Weber, I.; Appert-Rolland, C.; Schehr, G.; Santen, L.

    2017-11-01

    The cytoskeleton is an inhomogeneous network of semi-flexible filaments, which are involved in a wide variety of active biological processes. Although the cytoskeletal filaments can be very stiff and embedded in a dense and cross-linked network, it has been shown that, in cells, they typically exhibit significant bending on all length scales. In this work we propose a model of a semi-flexible filament deformed by different types of cross-linkers for which one can compute and investigate the bending spectrum. Our model allows to couple the evolution of the deformation of the semi-flexible polymer with the stochastic dynamics of linkers which exert transversal forces onto the filament. We observe a q-2 dependence of the bending spectrum for some biologically relevant parameters and in a certain range of wave numbers q, as observed in some experiments. However, generically, the spatially localized forcing and the non-thermal dynamics both introduce deviations from the thermal-like q-2 spectrum.

  15. Dynamics of neuromodulatory feedback determines frequency modulation in a reduced respiratory network: a computational study.

    PubMed

    Toporikova, Natalia; Butera, Robert J

    2013-02-01

    Neuromodulators, such as amines and neuropeptides, alter the activity of neurons and neuronal networks. In this work, we investigate how neuromodulators, which activate G(q)-protein second messenger systems, can modulate the bursting frequency of neurons in a critical portion of the respiratory neural network, the pre-Bötzinger complex (preBötC). These neurons are a vital part of the ponto-medullary neuronal network, which generates a stable respiratory rhythm whose frequency is regulated by neuromodulator release from the nearby Raphe nucleus. Using a simulated 50-cell network of excitatory preBötC neurons with a heterogeneous distribution of persistent sodium conductance and Ca(2+), we determined conditions for frequency modulation in such a network by simulating interaction between Raphe and preBötC nuclei. We found that the positive feedback between the Raphe excitability and preBötC activity induces frequency modulation in the preBötC neurons. In addition, the frequency of the respiratory rhythm can be regulated via phasic release of excitatory neuromodulators from the Raphe nucleus. We predict that the application of a G(q) antagonist will eliminate this frequency modulation by the Raphe and keep the network frequency constant and low. In contrast, application of a G(q) agonist will result in a high frequency for all levels of Raphe stimulation. Our modeling results also suggest that high [K(+)] requirement in respiratory brain slice experiments may serve as a compensatory mechanism for low neuromodulatory tone. Copyright © 2012 Elsevier B.V. All rights reserved.

  16. Effects of spatial constraints on channel network topology: Implications for geomorphological inference

    NASA Astrophysics Data System (ADS)

    Cabral, Mariza Castanheira De Moura Da Costa

    In the fifty-two years since Robert Horton's 1945 pioneering quantitative description of channel network planform (or plan view morphology), no conclusive findings have been presented that permit inference of geomorphological processes from any measures of network planform. All measures of network planform studied exhibit limited geographic variability across different environments. Horton (1945), Langbein et al. (1947), Schumm (1956), Hack (1957), Melton (1958), and Gray (1961) established various "laws" of network planform, that is, statistical relationships between different variables which have limited variability. A wide variety of models which have been proposed to simulate the growth of channel networks in time over a landsurface are generally also in agreement with the above planform laws. An explanation is proposed for the generality of the channel network planform laws. Channel networks must be space filling, that is, they must extend over the landscape to drain every hillslope, leaving no large undrained areas, and with no crossing of channels, often achieving a roughly uniform drainage density in a given environment. It is shown that the space-filling constraint can reduce the sensitivity of planform variables to different network growth models, and it is proposed that this constraint may determine the planform laws. The "Q model" of network growth of Van Pelt and Verwer (1985) is used to generate samples of networks. Sensitivity to the model parameter Q is markedly reduced when the networks generated are required to be space filling. For a wide variety of Q values, the space-filling networks are in approximate agreement with the various channel network planform laws. Additional constraints, including of energy efficiency, were not studied but may further reduce the variability of planform laws. Inference of model parameter Q from network topology is successful only in networks not subject to spatial constraints. In space-filling networks, for a wide range of Q values, the maximal-likelihood Q parameter value is generally in the vicinity of 1/2, which yields topological randomness. It is proposed that space filling originates the appearance of randomness in channel network topology, and may cause difficulties to geomorphological inference from network planform.

  17. Final Tactical Decision Aid (FTDA) for Infrared (8-12 Micrometers) Systems - Manual Version. Appendix B. Insolation and Sky Radiation Tables,

    DTIC Science & Technology

    1982-09-15

    for use in determining solar irradiance as a function of terrain elevation is also presented. Errors in computed sea level values of sky radiation as a...Renobserved if the Ground Were at Sea Level .. ..................... 365 5. Sky Radiation (W SK).. .. ....... ....... ....... 366 SKYY and Dewpoint SKY...WS -M 00 OiLn 00 00 00 .0 .. q . m1’ C14 IN’ .- *- * .0 *0 *0 0 .0 0 Y -’ CD N inC 0 M W N L- 04c 1- Wq an’ U) 14 N- 00 00 Mcq N N r- (’IC’I) (’ - M -0

  18. Robustness of network of networks under targeted attack.

    PubMed

    Dong, Gaogao; Gao, Jianxi; Du, Ruijin; Tian, Lixin; Stanley, H Eugene; Havlin, Shlomo

    2013-05-01

    The robustness of a network of networks (NON) under random attack has been studied recently [Gao et al., Phys. Rev. Lett. 107, 195701 (2011)]. Understanding how robust a NON is to targeted attacks is a major challenge when designing resilient infrastructures. We address here the question how the robustness of a NON is affected by targeted attack on high- or low-degree nodes. We introduce a targeted attack probability function that is dependent upon node degree and study the robustness of two types of NON under targeted attack: (i) a tree of n fully interdependent Erdős-Rényi or scale-free networks and (ii) a starlike network of n partially interdependent Erdős-Rényi networks. For any tree of n fully interdependent Erdős-Rényi networks and scale-free networks under targeted attack, we find that the network becomes significantly more vulnerable when nodes of higher degree have higher probability to fail. When the probability that a node will fail is proportional to its degree, for a NON composed of Erdős-Rényi networks we find analytical solutions for the mutual giant component P(∞) as a function of p, where 1-p is the initial fraction of failed nodes in each network. We also find analytical solutions for the critical fraction p(c), which causes the fragmentation of the n interdependent networks, and for the minimum average degree k[over ¯](min) below which the NON will collapse even if only a single node fails. For a starlike NON of n partially interdependent Erdős-Rényi networks under targeted attack, we find the critical coupling strength q(c) for different n. When q>q(c), the attacked system undergoes an abrupt first order type transition. When q≤q(c), the system displays a smooth second order percolation transition. We also evaluate how the central network becomes more vulnerable as the number of networks with the same coupling strength q increases. The limit of q=0 represents no dependency, and the results are consistent with the classical percolation theory of a single network under targeted attack.

  19. Determination of small-field correction factors for cylindrical ionization chambers using a semiempirical method

    NASA Astrophysics Data System (ADS)

    Park, Kwangwoo; Bak, Jino; Park, Sungho; Choi, Wonhoon; Park, Suk Won

    2016-02-01

    A semiempirical method based on the averaging effect of the sensitive volumes of different air-filled ionization chambers (ICs) was employed to approximate the correction factors for beam quality produced from the difference in the sizes of the reference field and small fields. We measured the output factors using several cylindrical ICs and calculated the correction factors using a mathematical method similar to deconvolution; in the method, we modeled the variable and inhomogeneous energy fluence function within the chamber cavity. The parameters of the modeled function and the correction factors were determined by solving a developed system of equations as well as on the basis of the measurement data and the geometry of the chambers. Further, Monte Carlo (MC) computations were performed using the Monaco® treatment planning system to validate the proposed method. The determined correction factors (k{{Q\\text{msr}},Q}{{f\\text{smf}}, {{f}\\text{ref}}} ) were comparable to the values derived from the MC computations performed using Monaco®. For example, for a 6 MV photon beam and a field size of 1  ×  1 cm2, k{{Q\\text{msr}},Q}{{f\\text{smf}}, {{f}\\text{ref}}} was calculated to be 1.125 for a PTW 31010 chamber and 1.022 for a PTW 31016 chamber. On the other hand, the k{{Q\\text{msr}},Q}{{f\\text{smf}}, {{f}\\text{ref}}} values determined from the MC computations were 1.121 and 1.031, respectively; the difference between the proposed method and the MC computation is less than 2%. In addition, we determined the k{{Q\\text{msr}},Q}{{f\\text{smf}}, {{f}\\text{ref}}} values for PTW 30013, PTW 31010, PTW 31016, IBA FC23-C, and IBA CC13 chambers as well. We devised a method for determining k{{Q\\text{msr}},Q}{{f\\text{smf}}, {{f}\\text{ref}}} from both the measurement of the output factors and model-based mathematical computation. The proposed method can be useful in case the MC simulation would not be applicable for the clinical settings.

  20. All Prime Contract Awards by State or Country, Place, and Contractor, FY 87. Part 14. Adelphia, New Jersey-White Sands Missile Range, New Mexico.

    DTIC Science & Technology

    1987-01-01

    N N N N N N N4 03100 9 0) 0 N000.J Nc 0 N0. N- 0 0... 0 N 0 0 cacao 010 0 00041 0 00-1 04 0 04- 0 041 0 0 i101001 0 0 0001- 0 004C 01- 0 01- 0 01- 0 0...hJ0000th 00 (I 0000000 9L I A004 I .4-4-el *-40 L) I in0 *.-44.4-eco L4.- " -0 M -eem-m4-e-4e-4- De ) ma~ *40) 0 *.m4 N 0001 CL 40 100 000O 0-00-0-0 x04...1-. Ln 4) 01 q 4 N de I l -*I 01 &1 ago 01 0 402 0 0 too1 up 4 4A ~ OA >. II U0 Z9 1’ 1 1o 0 0 30~~~ ~q 010. N 0. 1 (14- 1 (( 04 41N 01( 0 01( 3.4 0m

  1. Alpha List of Prime Contract Awards. Oct 92-Sep 93. FY93. (Oank8 Elbelco Inc. - Food Service Decor & Design). Part 7

    DTIC Science & Technology

    1994-03-01

    In = 4j 1 wow 11 (A com L) w U U) 04 ý4 0 u Ce ý4 0 0 Cie 0 Ix rý 00 .4 L) cc W 0 N C I cc" If x Q-J(Doý- x q1t (D 0 xooooý-- 0 L) 0 0 ý- CL. 0 m Ln...oCGoCOCO CON CN w 4 < 0 44 < O44 M -cvMN U (COO0-40(11 .-40 -40 OCOCCID(O 040 00W 04 NU) COM -i -444 0 N 0-4 if U.. a: a Ezz Z z 0 In0 000 a CV (0() 3n U4... coM 4)(4W-4 sN UN u m 4 - W gn N I 004- If > tcI Ny.4 -4 of0 X.4 cc (a 000000000001111111111Q0 N a I 004o- N1 as 4- -40-4 .4 -4 0 No tl 00 0

  2. U.S. EPA, Pesticide Product Label, MAB-250, 04/23/1985

    EPA Pesticide Factsheets

    2011-04-21

    ... ': (./ _.1" :--- Ic,;d -".n r.. f'. r"~tl11"" rn)(~lH'-t: ,~an.:'\\qPl (17) ~iSl nfpC'tf1.nt q Brand' pr"Ql!--f-rr-ttl'''JI l\\iVl~:l(\\r' rTS-/fll(') J: ~ .. T .~~,~t ~IJ~~ j ...

  3. A prospective study of meat, cooking methods, meat mutagens, heme iron, and lung cancer risks.

    PubMed

    Tasevska, Natasa; Sinha, Rashmi; Kipnis, Victor; Subar, Amy F; Leitzmann, Michael F; Hollenbeck, Albert R; Caporaso, Neil E; Schatzkin, Arthur; Cross, Amanda J

    2009-06-01

    Red and processed meat consumption may play a role in lung cancer pathogenesis because of these meats' fat and carcinogen content. We prospectively investigated whether meat type, cooking method, doneness level, and intake of specific meat mutagens and heme iron are associated with lung carcinoma. Men (n = 278,380) and women (n = 189,596) from the National Institutes of Health-AARP Diet and Health Study with no history of cancer at baseline were monitored for 8 y. Diet was assessed with a 124-item food-frequency questionnaire. A meat-cooking module was used to estimate the intake of individual heterocyclic amines, benzo(a)pyrene, and heme iron. Cox proportional hazards regression was used to estimate hazard ratios (HRs) and 95% CIs. In a comparison of quintiles 5 with 1 (Q5vsQ1), a high intake of red meat was associated with an increased risk of lung carcinoma in both men (HR(Q5vsQ1): 1.22; 95% CI: 1.09, 1.38; P for trend = 0.005) and women (HR(Q5vsQ1): 1.13; 95% CI: 0.97, 1.32; P for trend = 0.05). A high intake of processed meat increased the risk only in men (HR(Q5vsQ1): 1.23; 95% CI: 1.10, 1.37; P for trend = 0.003). In an analysis stratified by smoking status, we observed a tendency for an increased risk with red meat intake in never smoking men and women; however, the risks were not statistically significant. In a comparison of tertiles 3 and 1 (T3vsT1), the risk of lung carcinoma was associated with intake of well-/very-well-done meat (HR(T3vsT1): 1.20; 95% CI: 1.07, 1.35; P for trend = 0.002) and the intake of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (HR(Q5vsQ1): 1.20; 95% CI: 1.04, 1.38; P for trend = 0.04) in men. Heme iron intake increased the risk of lung carcinoma in both men (HR(Q5vsQ1): 1.25; 95% CI: 1.07, 1.45; P for trend = 0.02) and women (HR(Q5vsQ1): 1.18; 95% CI: 0.99, 1.42; P for trend = 0.002). We observed a moderate association between meat consumption and lung carcinoma, which might be explained by heme iron intake, high-temperature cooking, and associated mutagens.

  4. Search for pair-produced heavy quarks decaying to W q in the two-lepton channel at ( s ) = 7 TeV with the ATLAS detector

    DOE PAGES

    Aad, G.; Abbott, B.; Abdallah, J.; ...

    2012-07-23

    A search is presented for heavy-quark pair productionmore » $$Q\\bar{Q}$$ under the decay hypothesis $$Q\\bar{Q}$$→W +qW - $$\\bar{q}$$ with q = d, s, b for up-type Q or q = u, c for down-type Q. The search is performed with 1.04 fb -1 of integrated luminosity from pp collisions at $$\\sqrt{s}$$ =7 TeV collected by the ATLAS detector at the CERN LHC. Dilepton final states are selected, requiring large missing transverse momentum and at least two jets. Mass reconstruction of heavy-quark candidates is performed by assuming that the W boson decay products are nearly collinear. Lastly, the data are in agreement with standard model expectations; a heavy quark with mass less than 350 GeV is excluded at 95% confidence level.« less

  5. Pro-am collaborations with the Faulkes Telescopes, and the benefit to education, science and outreach awareness

    NASA Astrophysics Data System (ADS)

    Howes, N.; Miles, R.; Roche, P.

    2013-09-01

    The Faulkes Telescope Project is an educational and research arm of the Las Cumbres Observatory Global Telescope Network (LCOGTN). It has two 2-metre robotic telescopes, located at Haleakala on Maui (FT North) and Siding Spring in Australia (FT South). It is planned for these telescopes to be complemented by a research network of multiple 1-metre telescopes, along with an educational network of multiple 0.4-metre telescopes, providing 24-hour coverage of both northern and southern hemispheres. The telescope network is unique in that it provides school students with access to research grade instrumentation in the United Kingdom and several other countries across Europe as well as in Hawaii. Over the past few years, amateur astronomers have increasingly been working with schools suggesting projects which have provided valuable scientific input to professional astronomers. This poster aims to present several of the key results and observations where professional astronomers have cited and used this data obtained with the Faulkes Telescope, notably - Observations and results from the global campaign on Comet C/2007 Q3 ; Ref.[2] - Observations of the fragmentation of Comet 168P; Ref.[3] - Observations relating to the evolution of Comet C/2012 S1; Ref.[4] - Observations and imaging of the Jupiter-family comet, P/2010 TO20; Ref.[5

  6. The association between socioeconomic factors and breast cancer-specific survival varies by race.

    PubMed

    Agarwal, Shailesh; Ying, Jian; Boucher, Kenneth M; Agarwal, Jayant P

    2017-01-01

    Although racial disparity is well described for oncologic outcomes, factors associated with survival within racial groups remains unexplored. The objective of this study is to determine whether breast cancer survival among White or Black patients is associated with differing patient factors. Women diagnosed with breast cancer from 1998 through 2012 were identified in the Surveillance, Epidemiology, and End Results (SEER) database. Cox proportional hazard logistic regression was used to estimate cause-specific survival in the combined cohort, and separate cohorts of Black or White patients only. Main outcomes included cause-specific survival in cohorts of Black only, White only, or all patients adjusted for demographic and oncologic factors. A total of 406,907 Black (10.8%) or White (89.2%) patients diagnosed with breast cancer from 1998 through 2012 were isolated. Cancer-specific survival analysis of the combined cohort showed significantly decreased hazard ratio (H.R.) in patients from the higher economic quartiles (Q1: 1.0 (ref), Q2: 0.95 (p<0.01), Q3: 0.94 (p<0.01), Q4: 0.87 (p<0.001)). Analysis of the White only cohort showed a similar relationship with income (Q1: 1.0 (ref), Q2: 0.95 (p<0.01), Q3: 0.95 (p<0.01), Q4: 0.86 (p<0.001)). However, analysis of the Black only cohort did not show a relationship with income (Q1: 1.0 (ref), Q2: 1.04 (p = 0.34), Q3: 0.97 (p = 0.53), Q4: 1.04 (p = 0.47)). A test of interaction confirmed that the association between income and cancer-specific survival is dependent on patient race, both with and without adjustment for demographic and oncologic characteristics (p<0.01). While median county income is positively associated with cancer-specific survival among White patients, this is not the case with Black patients. Similar findings were noted for education level. These findings suggest that the association between socioeconomic status and breast cancer survival commonly reported in the literature is specific to White patients. These findings provide insight into differences between White and Black patients in cancer-specific survival.

  7. Radiofrequency ablation of liver metastases-software-assisted evaluation of the ablation zone in MDCT: tumor-free follow-up versus local recurrent disease.

    PubMed

    Keil, Sebastian; Bruners, Philipp; Schiffl, Katharina; Sedlmair, Martin; Mühlenbruch, Georg; Günther, Rolf W; Das, Marco; Mahnken, Andreas H

    2010-04-01

    The purpose of this study was to investigate differences in change of size and CT value between local recurrences and tumor-free areas after CT-guided radiofrequency ablation (RFA) of hepatic metastases during follow-up by means of dedicated software for automatic evaluation of hepatic lesions. Thirty-two patients with 54 liver metastases from breast or colorectal cancer underwent triphasic contrast-enhanced multidetector-row computed tomography (MDCT) to evaluate hepatic metastatic spread and localization before CT-guided RFA and for follow-up after intervention. Sixteen of these patients (65.1 + or - 10.3 years) with 30 metastases stayed tumor-free (group 1), while the other group (n = 16 with 24 metastases; 62.0 + or - 13.8 years) suffered from local recurrent disease (group 2). Applying an automated software tool (SyngoCT Oncology; Siemens Healthcare, Forchheim, Germany), size parameters (volume, RECIST, WHO) and attenuation were measured within the lesions before, 1 day after, and 28 days after RFA treatment. The natural logarithm (ln) of the quotient of the volume 1 day versus 28 days after RFA treament was computed: lnQ1//28/0(volume). Analogously, ln ratios of RECIST, WHO, and attenuation were computed and statistically evaluated by repeated-measures ANOVA. One lesion in group 2 was excluded from further evaluation due to automated missegmentation. Statistically significant differences between the two groups were observed with respect to initial volume, RECIST, and WHO (p < 0.05). Furthermore, ln ratios corresponding to volume, RECIST, and WHO differed significantly between the two groups. Attenuation evaluations showed no significant differences, but there was a trend toward attenuation assessment for the parameter lnQ28/0(attenuation) (p = 0.0527), showing higher values for group 1 (-0.4 + or - 0.3) compared to group 2 (-0.2 + or - 0.2). In conclusion, hepatic metastases and their zone of coagulation necrosis after RFA differed significantly between tumor-free and local-recurrent ablation zones with respect to the corresponding size parameters. A new parameter (lnQ1//28/0(volume/RECIST/WHO/attenuation)) was introduced, which appears to be of prognostic value at early follow-up CT.

  8. IEEE International Symposium Information Theory, held at Santa Monica California, February 9-12, 1981.

    DTIC Science & Technology

    1981-01-01

    Channel and study permutation codes as a special case. ,uch a code is generated by an initial vector x, a group G of orthogonal n by n matrices, and a...random-access components, is introduced and studied . Under this scheme, the network stations are divided into groups , each of which is assigned a...IEEE INFORMATION THEORY GROUP CO-SPONSORED BY: UNION RADIO SCIENTIFIQUE INTERNATIONALE IEEE Catalog Number 81 CH 1609-7 IT 𔃻. 81 ~20 04Q SECURITY

  9. HEC-4 Monthly Streamflow Simulation (User’s Manual)

    DTIC Science & Technology

    1971-02-01

    adding this product to the uroduct of the complement of this multiplier and the value of the ele - ment in the inconsistent matrix. The averaged or...the month pre- ceding the first month specified (by input data) to be generated. The var-’ ele M.1A is comnutel f’or the subscript o" ; that conforms...1-4 .f’o .Td74 r m 1i4 tf’t 0atQ P PkPkk4 el %04 k04 fl 0 -41. ----- 4-4-4 a-4 -44 44-4- - -4 *fF_4Q cacao---1 00 0404- -4 Cb 0 0-r-o .0. 4

  10. A stream-gaging network analysis for the 7-day, 10-year annual low flow in New Hampshire streams

    USGS Publications Warehouse

    Flynn, Robert H.

    2003-01-01

    The 7-day, 10-year (7Q10) low-flow-frequency statistic is a widely used measure of surface-water availability in New Hampshire. Regression equations and basin-characteristic digital data sets were developed to help water-resource managers determine surface-water resources during periods of low flow in New Hampshire streams. These regression equations and data sets were developed to estimate streamflow statistics for the annual and seasonal low-flow-frequency, and period-of-record and seasonal period-of-record flow durations. generalized-least-squares (GLS) regression methods were used to develop the annual 7Q10 low-flow-frequency regression equation from 60 continuous-record stream-gaging stations in New Hampshire and in neighboring States. In the regression equation, the dependent variables were the annual 7Q10 flows at the 60 stream-gaging stations. The independent (or predictor) variables were objectively selected characteristics of the drainage basins that contribute flow to those stations. In contrast to ordinary-least-squares (OLS) regression analysis, GLS-developed estimating equations account for differences in length of record and spatial correlations among the flow-frequency statistics at the various stations.A total of 93 measurable drainage-basin characteristics were candidate independent variables. On the basis of several statistical parameters that were used to evaluate which combination of basin characteristics contribute the most to the predictive power of the equations, three drainage-basin characteristics were determined to be statistically significant predictors of the annual 7Q10: (1) total drainage area, (2) mean summer stream-gaging station precipitation from 1961 to 90, and (3) average mean annual basinwide temperature from 1961 to 1990.To evaluate the effectiveness of the stream-gaging network in providing regional streamflow data for the annual 7Q10, the computer program GLSNET (generalized-least-squares NETwork) was used to analyze the network by application of GLS regression between streamflow and the climatic and basin characteristics of the drainage basin upstream from each stream-gaging station. Improvement to the predictive ability of the regression equations developed for the network analyses is measured by the reduction in the average sampling-error variance, and can be achieved by collecting additional streamflow data at existing stations. The predictive ability of the regression equations is enhanced even further with the addition of new stations to the network. Continued data collection at unregulated stream-gaging stations with less than 14 years of record resulted in the greatest cost-weighted reduction to the average sampling-error variance of the annual 7Q10 regional regression equation. The addition of new stations in basins with underrepresented values for the independent variables of the total drainage area, average mean annual basinwide temperature, or mean summer stream-gaging station precipitation in the annual 7Q10 regression equation yielded a much greater cost-weighted reduction to the average sampling-error variance than when more data were collected at existing unregulated stations. To maximize the regional information obtained from the stream-gaging network for the annual 7Q10, ranking of the streamflow data can be used to determine whether an active station should be continued or if a new or discontinued station should be activated for streamflow data collection. Thus, this network analysis can help determine the costs and benefits of continuing the operation of a particular station or activating a new station at another location to predict the 7Q10 at ungaged stream reaches. The decision to discontinue an existing station or activate a new station, however, must also consider its contribution to other water-resource analyses such as flood management, water quality, or trends in land use or climatic change.

  11. 26 CFR 1.408A-9 - Effective date.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 5 2010-04-01 2010-04-01 false Effective date. 1.408A-9 Section 1.408A-9...) INCOME TAXES Pension, Profit-Sharing, Stock Bonus Plans, Etc. § 1.408A-9 Effective date. This section contains the following question and answer providing the effective date of §§ 1.408A-1 through 1.408A-8: Q...

  12. 26 CFR 1.103(n)-6T - Determinations of population (temporary).

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 2 2014-04-01 2014-04-01 false Determinations of population (temporary). 1.103....103(n)-6T Determinations of population (temporary). Q-1: What is the proper method for determining population? A-1: All determinations of population must be made with respect to any calendar year on the basis...

  13. 26 CFR 1.103(n)-6T - Determinations of population (temporary).

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 2 2013-04-01 2013-04-01 false Determinations of population (temporary). 1.103....103(n)-6T Determinations of population (temporary). Q-1: What is the proper method for determining population? A-1: All determinations of population must be made with respect to any calendar year on the basis...

  14. 26 CFR 1.103(n)-6T - Determinations of population (temporary).

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 2 2012-04-01 2012-04-01 false Determinations of population (temporary). 1.103....103(n)-6T Determinations of population (temporary). Q-1: What is the proper method for determining population? A-1: All determinations of population must be made with respect to any calendar year on the basis...

  15. 26 CFR 1.419-1T - Treatment of welfare benefit funds. (Temporary)

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... portion of a child care facility used in the provision of welfare benefits for a year will include the... 26 Internal Revenue 5 2012-04-01 2011-04-01 true Treatment of welfare benefit funds. (Temporary) 1.... § 1.419-1T Treatment of welfare benefit funds. (Temporary) Q-1: What does section 419 of the Internal...

  16. Numerical computation of the effective-one-body potential q using self-force results

    NASA Astrophysics Data System (ADS)

    Akcay, Sarp; van de Meent, Maarten

    2016-03-01

    The effective-one-body theory (EOB) describes the conservative dynamics of compact binary systems in terms of an effective Hamiltonian approach. The Hamiltonian for moderately eccentric motion of two nonspinning compact objects in the extreme mass-ratio limit is given in terms of three potentials: a (v ) , d ¯ (v ) , q (v ) . By generalizing the first law of mechanics for (nonspinning) black hole binaries to eccentric orbits, [A. Le Tiec, Phys. Rev. D 92, 084021 (2015).] recently obtained new expressions for d ¯(v ) and q (v ) in terms of quantities that can be readily computed using the gravitational self-force approach. Using these expressions we present a new computation of the EOB potential q (v ) by combining results from two independent numerical self-force codes. We determine q (v ) for inverse binary separations in the range 1 /1200 ≤v ≲1 /6 . Our computation thus provides the first-ever strong-field results for q (v ) . We also obtain d ¯ (v ) in our entire domain to a fractional accuracy of ≳10-8 . We find that our results are compatible with the known post-Newtonian expansions for d ¯(v ) and q (v ) in the weak field, and agree with previous (less accurate) numerical results for d ¯(v ) in the strong field.

  17. Scaling properties of observed and simulated satellite visible radiances

    NASA Astrophysics Data System (ADS)

    Barker, Howard W.; Qu, Zhipeng; Bélair, Stéphane; Leroyer, Sylvie; Milbrandt, Jason A.; Vaillancourt, Paul A.

    2017-09-01

    Structure functions Sq, which are related to power spectra and used to study turbulence, were computed for GOES-13 visible radiances measured on 16 May 2015 over French Guiana and adjacent Atlantic Ocean. The nested Global Environmental Multiscale (GEM) numerical weather prediction (NWP) model was run for the same time and area. Cloud data generated by GEM over (300 km)2 domains, with one-way nesting ending at horizontal grid-spacing of 0.25 km, were operated on by a 3-D solar radiative transfer model with resulting radiances degraded to GOES-13 resolution ( 1 km) and Sq computed for them, too. For GOES-13 radiances, scaling exponents ζ(2) associated with S2, for separation distances between 5 km and 25 km, were typically >0.6 for deep convective and marine boundary layer clouds and <0.4 for shallow cumuli over land. ζ(2) for GEM agreed well with GOES-13 for deep convective clouds. This suggests that the self-organizing properties of deep convection in GEM exhibit realistic geometric features, a potentially important point given the link between cloud structure and precipitation, with the latter being much more difficult to measure and assess than visible radiances. Regarding radiances for GEM's marine boundary layer clouds, their Sq differed markedly from GOES-13's; better resembling fair-weather cumulus. Likewise, GEM's shallow cumuli over land appear to have bypassed the "scattered" fair-weather stage and went straight into more organized convection. Thus, it appears that comparing time series of Sq for geostationary satellite data and corresponding modeled radiances has the potential to benefit assessment of cloud system-resolving models.

  18. 20 CFR 404.1519q - Conflict of interest.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Conflict of interest. 404.1519q Section 404... INSURANCE (1950- ) Determining Disability and Blindness Standards for the Type of Referral and for Report Content § 404.1519q Conflict of interest. All implications of possible conflict of interest between...

  19. 20 CFR 416.919q - Conflict of interest.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Conflict of interest. 416.919q Section 416..., BLIND, AND DISABLED Determining Disability and Blindness Standards for the Type of Referral and for Report Content § 416.919q Conflict of interest. All implications of possible conflict of interest between...

  20. Prognostic implications of Q waves at presentation in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: An analysis of the HORIZONS-AMI study.

    PubMed

    Kosmidou, Ioanna; Redfors, Björn; Crowley, Aaron; Gersh, Bernard; Chen, Shmuel; Dizon, José M; Embacher, Monica; Mehran, Roxana; Ben-Yehuda, Ori; Mintz, Gary S; Stone, Gregg W

    2017-11-01

    Presence of Q waves on the presenting electrocardiogram (ECG) in patients with ST-segment elevation myocardial infarction (STEMI) has been associated with worse prognosis; however, whether the prognostic value of Q waves is influenced by baseline characteristics and/or rapidity of revascularization based on the guideline-based metric of door-to-balloon time remains unknown. We hypothesized that Q waves in the presenting ECG will be predictive of long term mortality regardless of time to reperfusion. The Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction (HORIZONS-AMI) trial enrolled 3602 patients with STEMI undergoing primary percutaneous coronary intervention. We stratified patients without prior history of myocardial infarction or coronary revascularization according to presence or absence of pathological Q waves on their presenting ECG. Associations between Q waves, death, and cardiovascular outcomes within 3 years were assessed using Cox proportional hazards regression. Among 2723 patients with evaluable ECGs, 1084 (39.8%) had Q waves on their presenting ECG. Male sex and time from symptom onset to balloon inflation were independent predictors of presence of Q waves. Patients with Q waves had higher adjusted risks of all-cause death (adjusted hazard ratio: 1.45, 95% confidence interval: 1.02-2.05, P = 0.04) and cardiac death (adjusted hazard ratio: 1.72, 95% confidence interval: 1.08-2.72, P = 0.02). The association between Q waves and cardiac death was consistent regardless of sex, diabetes status, target vessel, or door-to-balloon time (P interaction > 0.4 for all). Presence of Q waves on the presenting ECG in patients undergoing primary percutaneous coronary intervention due to STEMI is an independent predictor of mortality and adds prognostic value, regardless of sex or rapidity of revascularization. © 2017 Wiley Periodicals, Inc.

  1. Contrasting hydraulic architecture and function in deep and shallow roots of tree species from a semi-arid habitat

    PubMed Central

    Johnson, Daniel M.; Brodersen, Craig R.; Reed, Mary; Domec, Jean-Christophe; Jackson, Robert B.

    2014-01-01

    Background and Aims Despite the importance of vessels in angiosperm roots for plant water transport, there is little research on the microanatomy of woody plant roots. Vessels in roots can be interconnected networks or nearly solitary, with few vessel–vessel connections. Species with few connections are common in arid habitats, presumably to isolate embolisms. In this study, measurements were made of root vessel pit sizes, vessel air-seeding pressures, pit membrane thicknesses and the degree of vessel interconnectedness in deep (approx. 20 m) and shallow (<10 cm) roots of two co-occurring species, Sideroxylon lanuginosum and Quercus fusiformis. Methods Scanning electron microscopy was used to image pit dimensions and to measure the distance between connected vessels. The number of connected vessels in larger samples was determined by using high-resolution computed tomography and three-dimensional (3-D) image analysis. Individual vessel air-seeding pressures were measured using a microcapillary method. The thickness of pit membranes was measured using transmission electron microscopy. Key Results Vessel pit size varied across both species and rooting depths. Deep Q. fusiformis roots had the largest pits overall (>500 µm) and more large pits than either shallow Q. fusiformis roots or S. lanuginosum roots. Vessel air-seeding pressures were approximately four times greater in Q. fusiformis than in S. lanuginosum and 1·3–1·9 times greater in shallow roots than in deep roots. Sideroxylon lanuginosum had 34–44 % of its vessels interconnected, whereas Q. fusiformis only had 1–6 % of its vessels connected. Vessel air-seeding pressures were unrelated to pit membrane thickness but showed a positive relationship with vessel interconnectedness. Conclusions These data support the hypothesis that species with more vessel–vessel integration are often less resistant to embolism than species with isolated vessels. This study also highlights the usefulness of tomography for vessel network analysis and the important role of 3-D xylem organization in plant hydraulic function. PMID:24363350

  2. 26 CFR 1.103(n)-3T - Private activity bond limit (temporary).

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 2 2011-04-01 2011-04-01 false Private activity bond limit (temporary). 1.103(n)-3T Section 1.103(n)-3T Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY....103(n)-3T Private activity bond limit (temporary). Q-1: What is the “State ceiling”? A-1: In general...

  3. 26 CFR 1.103(n)-3T - Private activity bond limit (temporary).

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 2 2010-04-01 2010-04-01 false Private activity bond limit (temporary). 1.103(n)-3T Section 1.103(n)-3T Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY....103(n)-3T Private activity bond limit (temporary). Q-1: What is the “State ceiling”? A-1: In general...

  4. 26 CFR 1.419-1T - Treatment of welfare benefit funds. (Temporary)

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... portion of a child care facility used in the provision of welfare benefits for a year will include the... 26 Internal Revenue 5 2013-04-01 2013-04-01 false Treatment of welfare benefit funds. (Temporary.... § 1.419-1T Treatment of welfare benefit funds. (Temporary) Q-1: What does section 419 of the Internal...

  5. 26 CFR 1.419-1T - Treatment of welfare benefit funds. (Temporary)

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... portion of a child care facility used in the provision of welfare benefits for a year will include the... 26 Internal Revenue 5 2014-04-01 2014-04-01 false Treatment of welfare benefit funds. (Temporary.... § 1.419-1T Treatment of welfare benefit funds. (Temporary) Q-1: What does section 419 of the Internal...

  6. Extension and Validation of Research on Acquisition and Retention of Cognitive versus Perceptually Oriented Training Materials

    DTIC Science & Technology

    1980-06-01

    Conservative/Experimenting V2d Q2 Group-dependent/Sel f-sufficient V29 Q3 Undisciplined Self-conflict/ Controlled V30 Q4 Relaxed/Tense V4C GZPS Guilford...d7 O 6.5738 2. 1327 61 V2h 02 5.0984 2.2709 61 V29 03 7.3164 1.9958 61 V00 04 4 .98 3o 2.0453 61 V40 GZpS 33.1475 10.0?27 61 Isr 1 95574 5.3899 61 114...sufficient V29 Q3 Undisciplined Self-conflict/ Controlled V30 Q4 Relaxed/Tense V40 GZPS Guilford Zimmerman Perceptual Speed ZR6 ZOVERALL Standardized

  7. Weyerhaeuser Export Facility at DuPont. Volume III. Appendices R - T.

    DTIC Science & Technology

    1982-05-01

    o 1 0N. u 𔃺-43-.Ell. in- All~ 4E-W -Sl >.41 03..l 0 -. 0.El El4 -0 00. ElE w wo El0 0 E.W a A44 l iV t 4 r A - - . 1 %9C 4 U. o U 10 ).- 3W 4 aQ 4...8217 , u =1 0.H, a t 0𔃺 El4 2-0.4 4 00 LI 40. -0 f.. N . .2 C 44 04 >, . 00 a 10 0 ~ 01 020 0 *. 20A 3. 40 04 .4 a,4 - 44 4 E 0 A2. U.~E4 Q 4 4.0 0 6.a

  8. 26 CFR 1.921-2 - Foreign Sales Corporation-general rules.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 10 2011-04-01 2011-04-01 false Foreign Sales Corporation-general rules. 1.921... Foreign Sales Corporation—general rules. (a) Definition of a FSC and the Effect of a FSC Election. Q-1. What is the definition of a Foreign Sales Corporation (hereinafter referred to as a “FSC” (All...

  9. 26 CFR 1.921-2 - Foreign Sales Corporation-general rules.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 10 2012-04-01 2012-04-01 false Foreign Sales Corporation-general rules. 1.921... Foreign Sales Corporation—general rules. (a) Definition of a FSC and the Effect of a FSC Election. Q-1. What is the definition of a Foreign Sales Corporation (hereinafter referred to as a “FSC” (All...

  10. 26 CFR 1.921-2 - Foreign Sales Corporation-general rules.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 10 2013-04-01 2013-04-01 false Foreign Sales Corporation-general rules. 1.921... Foreign Sales Corporation—general rules. (a) Definition of a FSC and the Effect of a FSC Election. Q-1. What is the definition of a Foreign Sales Corporation (hereinafter referred to as a “FSC” (All...

  11. 26 CFR 1.921-2 - Foreign Sales Corporation-general rules.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 10 2014-04-01 2013-04-01 true Foreign Sales Corporation-general rules. 1.921-2... Sales Corporation—general rules. (a) Definition of a FSC and the Effect of a FSC Election. Q-1. What is the definition of a Foreign Sales Corporation (hereinafter referred to as a “FSC” (All references to...

  12. 26 CFR 1.401(a)(9)-3 - Death before required beginning date.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 5 2010-04-01 2010-04-01 false Death before required beginning date. 1.401(a)(9...)-3 Death before required beginning date. Q-1. If an employee dies before the employee's required... within 5 years of the employee's death regardless of who or what entity receives the distribution...

  13. Double-Line-Frequency Ripple Model, Analysis & Impedance Design for Energy Stored Single-Phase Quasi-Z Source Photovoltaic System

    DOE PAGES

    Liang, Weihua; Liu, Yushan; Ge, Baoming; ...

    2017-09-08

    The battery energy stored quasi-Z-source (BESqZS) based photovoltaic (PV) power generation system combines advantages of the qZS inverter and the battery energy storage system. But, the second harmonic (2ω) power ripple degrades the system’s performance and affects the system’s design. An accurate model to analyze the 2ω ripple is very important. The existing models did not consider the battery, or assumed a symmetric qZS network with L 1=L 2 and C 1=C 2, which limits the design freedom and causes oversized impedance parameters. Our paper proposes a comprehensive model for the single-phase BES-qZS-PV inverter system, where the battery is consideredmore » and there is no restriction of L 1=L 2 and C 1=C 2. Based on the built model, a BES-qZS impedance design method is proposed to mitigate the 2ω ripple with asymmetric qZS network. Simulation and experimental results verify the proposed 2ω ripple model and impedance design method.« less

  14. Double-Line-Frequency Ripple Model, Analysis & Impedance Design for Energy Stored Single-Phase Quasi-Z Source Photovoltaic System

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Liang, Weihua; Liu, Yushan; Ge, Baoming

    The battery energy stored quasi-Z-source (BESqZS) based photovoltaic (PV) power generation system combines advantages of the qZS inverter and the battery energy storage system. But, the second harmonic (2ω) power ripple degrades the system’s performance and affects the system’s design. An accurate model to analyze the 2ω ripple is very important. The existing models did not consider the battery, or assumed a symmetric qZS network with L 1=L 2 and C 1=C 2, which limits the design freedom and causes oversized impedance parameters. Our paper proposes a comprehensive model for the single-phase BES-qZS-PV inverter system, where the battery is consideredmore » and there is no restriction of L 1=L 2 and C 1=C 2. Based on the built model, a BES-qZS impedance design method is proposed to mitigate the 2ω ripple with asymmetric qZS network. Simulation and experimental results verify the proposed 2ω ripple model and impedance design method.« less

  15. 17 CFR 240.15d-13 - Quarterly reports on Form 10-Q (§ 249.308 of this chapter).

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Quarterly reports on Form 10-Q... reports on Form 10-Q (§ 249.308 of this chapter). (a) Except as provided in paragraphs (b) and (c) of this... file a quarterly report on Form 10-Q (§ 249.308 of this chapter) within the period specified in General...

  16. 17 CFR 240.15d-13 - Quarterly reports on Form 10-Q (§ 249.308 of this chapter).

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 3 2012-04-01 2012-04-01 false Quarterly reports on Form 10-Q... reports on Form 10-Q (§ 249.308 of this chapter). (a) Except as provided in paragraphs (b) and (c) of this... file a quarterly report on Form 10-Q (§ 249.308 of this chapter) within the period specified in General...

  17. 17 CFR 240.15d-13 - Quarterly reports on Form 10-Q (§ 249.308 of this chapter).

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Quarterly reports on Form 10-Q... reports on Form 10-Q (§ 249.308 of this chapter). (a) Except as provided in paragraphs (b) and (c) of this... file a quarterly report on Form 10-Q (§ 249.308 of this chapter) within the period specified in General...

  18. 17 CFR 240.15d-13 - Quarterly reports on Form 10-Q (§ 249.308 of this chapter).

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 4 2014-04-01 2014-04-01 false Quarterly reports on Form 10-Q... reports on Form 10-Q (§ 249.308 of this chapter). (a) Except as provided in paragraphs (b) and (c) of this... file a quarterly report on Form 10-Q (§ 249.308 of this chapter) within the period specified in General...

  19. 17 CFR 240.15d-13 - Quarterly reports on Form 10-Q (§ 249.308 of this chapter).

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 3 2013-04-01 2013-04-01 false Quarterly reports on Form 10-Q... reports on Form 10-Q (§ 249.308 of this chapter). (a) Except as provided in paragraphs (b) and (c) of this... file a quarterly report on Form 10-Q (§ 249.308 of this chapter) within the period specified in General...

  20. USACERL Report Bibliography.

    DTIC Science & Technology

    1980-12-01

    LV h3ct m- C a10 L EE Z 0 to 000 0 0 I0Z4 4-- 0J U. >4j n -o tt Cr C. )04: OtD L. 0 . 0. --o 0A 0 10 t- t- - 4- >_ xAt) 0 0 40 > go~ 100 U C>. -- 4...0 C in*>Q -1 a)11 10-) 0 MU- ’o -1 0 . 0W 0- - - -a O C S CC _ U b C. o - 0 - 0 0 -In - C 100 V.01 0 01 -e !- -)to t o 4 L 00~’ t-0 01 101 10 In W...L -A 10 0 (0 c. 0n 4- U) 04 L OV 2 100 4)5 0M 1 - 0 ’s- C- < m 0) 04) mC 0 - C . CLSV 0-> (n >4 (0 0 -- U 40C . ZC L -01 0 .-- W . 0. VE 0~ lb 4) 00 Q

  1. The structure of Er3+-doped oxy-fluoride transparent glass-ceramics studied by Raman scattering

    NASA Astrophysics Data System (ADS)

    Tikhomirov, V. K.; Seddon, A. B.; Ferrari, M.; Montagna, M.; Santos, L. F.; Almeida, R. M.

    2003-11-01

    We show that the structure of transparent oxy-fluoride glass-ceramics formed by heat treatment of glasses of typical composition 32(SiO2):9(AlO1.5):31.5(CdF2):18.5(PbF2): 5.5(ZnF2):3.5(ErF3) mol% consists of ~ 12 nm diameter, Er3+-doped, β-PbF2 nano-crystals embedded in a silica-based glass network and connected to it via non-bridging O and F anions, or fluorine linkages such as Pb-F-Cd and Pb-F-Zn. It is proposed that the glass network structure is mostly chain-like and dominated by Si(O,F)4 tetrahedra with two bridging O and two non-bridging O and/or F atoms (Q2 units). SiO4 tetrahedra with zero and one bridging O (Q0 and Q1 units, respectively) are also present in the glass structure, in the approximate proportion Q0:Q1:Q2 = 1:1:3, a characteristic which appears to be of primary importance. The flexible, chain-like glass-network, with many broken bonds, results in easy accommodation of the Er3+-doped PbF2 nano-crystals, which are grown by heat-treatment of the precursor glass. The boson peak in the Raman spectrum of the precursor glass decreases in intensity upon ceramming and is partly converted to narrow crystalline peaks at lower frequency, consistent with the precipitation of PbF2 crystalline nano-particles. It is suggested that the boson peak involves localized vibrations of broken or stretched Pb-F bonds. The mean free path for these vibrations increases with ceramming, which involves partial crystallization of the glass network, resulting in a shift of the boson peak vibrations to lower-frequency crystalline peaks.

  2. 26 CFR 1.401(a)(9)-9 - Life expectancy and distribution period tables.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 5 2014-04-01 2014-04-01 false Life expectancy and distribution period tables... Plans, Etc. § 1.401(a)(9)-9 Life expectancy and distribution period tables. Q-1. What is the life...)(9)? A-1 The following table, referred to as the Single Life Table, is used for determining the life...

  3. 26 CFR 1.401(a)(9)-3 - Death before required beginning date.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 5 2014-04-01 2014-04-01 false Death before required beginning date. 1.401(a)(9.... § 1.401(a)(9)-3 Death before required beginning date. Q-1. If an employee dies before the employee's... employee be distributed within 5 years of the employee's death regardless of who or what entity receives...

  4. 26 CFR 1.401(a)(9)-3 - Death before required beginning date.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 5 2011-04-01 2011-04-01 false Death before required beginning date. 1.401(a)(9.... § 1.401(a)(9)-3 Death before required beginning date. Q-1. If an employee dies before the employee's... employee be distributed within 5 years of the employee's death regardless of who or what entity receives...

  5. 26 CFR 1.401(a)(9)-3 - Death before required beginning date.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 5 2013-04-01 2013-04-01 false Death before required beginning date. 1.401(a)(9.... § 1.401(a)(9)-3 Death before required beginning date. Q-1. If an employee dies before the employee's... employee be distributed within 5 years of the employee's death regardless of who or what entity receives...

  6. 26 CFR 1.401(a)(9)-3 - Death before required beginning date.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 5 2012-04-01 2011-04-01 true Death before required beginning date. 1.401(a)(9.... § 1.401(a)(9)-3 Death before required beginning date. Q-1. If an employee dies before the employee's... employee be distributed within 5 years of the employee's death regardless of who or what entity receives...

  7. All Prime Contract Awards by State or Country, Place, and Contractor. Part 22 (Aua Amer-Honduras)

    DTIC Science & Technology

    1990-01-01

    5 01 񓡞i 0 La 4. U.444.4 4c 4c 41* UWl dc 4c...4C C. 0 d IL ~a.4 MW 1-1 U be 0 a 00003 0 mU 0 * a I 10.4 CD LL 00 Go G00 40 0000 1-1 qW In 0 40 t&. - 5 -4 -i..t- maoooonon 04.)m -im’ 000o >.a 0 . CV...00 t 2 Q0000000 OaN xa i004 aNO4 5 -1- J-JIJ-J 00 0 00f 0.4c 000000 0 1010CL a41 d-# 1 300000 22 1 00 wa 00000000 02 -9 a 3 4") a~ A -4-4 .4 -4-4 a 0

  8. Assessing CpG island methylator phenotype, 1p/19q codeletion, and MGMT promoter methylation from epigenome-wide data in the biomarker cohort of the NOA-04 trial

    PubMed Central

    Wiestler, Benedikt; Capper, David; Hovestadt, Volker; Sill, Martin; Jones, David T.W.; Hartmann, Christian; Felsberg, Joerg; Platten, Michael; Feiden, Wolfgang; Keyvani, Kathy; Pfister, Stefan M.; Wiestler, Otmar D.; Meyermann, Richard; Reifenberger, Guido; Pietsch, Thorsten; von Deimling, Andreas; Weller, Michael; Wick, Wolfgang

    2014-01-01

    Background Molecular biomarkers including isocitrate dehydrogenase 1 or 2 (IDH1/2) mutation, 1p/19q codeletion, and O6-methylguanine-DNA-methyltransferase (MGMT) promoter methylation may improve prognostication and guide treatment decisions for patients with World Health Organization (WHO) anaplastic gliomas. At present, each marker is individually tested by distinct assays. Illumina Infinium HumanMethylation450 BeadChip arrays (HM450) enable the determination of large-scale methylation profiles and genome-wide DNA copy number changes. Algorithms have been developed to detect the glioma CpG island methylator phenotype (G-CIMP) associated with IDH1/2 mutation, 1p/19q codeletion, and MGMT promoter methylation using a single assay. Methods Here, we retrospectively investigated the diagnostic and prognostic performance of these algorithms in comparison to individual marker testing and patient outcome in the biomarker cohort (n = 115 patients) of the NOA-04 trial. Results Concordance for IDH and 1p/19q status was very high: In 92% of samples, the HM450 and reference data agreed. In discordant samples, survival analysis by Kaplan-Meier and Cox regression analyses suggested a more accurate assessment of biological phenotype by the HM450 analysis. The HM450-derived MGMT-STP27 model to calculate MGMT promoter methylation probability revealed this aberration in a significantly higher fraction of samples than conventional methylation-specific PCR, with 87 of 91 G-CIMP tumors predicted as MGMT promoter-methylated. Pyrosequencing of discordant samples confirmed the HM450 assessment in 14 of 17 cases. Conclusions G-CIMP and 1p/19q codeletion are reliably detectable by HM450 analysis and are associated with prognosis in the NOA-04 trial. For MGMT, HM450 suggests promoter methylation in the vast majority of G-CIMP tumors, which is supported by pyrosequencing. PMID:25028501

  9. Inhibition of biofilm in Bacillus amyloliquefaciens Q-426 by diketopiperazines.

    PubMed

    Wang, Jian-Hua; Yang, Cui-Yun; Fang, Sheng-Tao; Lu, Jian; Quan, Chun-Shan

    2016-09-01

    Biofilm formation can make significant effects on bacteria habits and biological functions. In this study, diketopiperazines (DKPs) produced by strain of Bacillus amyloliquefaciens Q-426 was found to inhibit biofilm formed in the gas-liquid interface. Four kinds of DKPs were extracted from B. amyloliquefaciens Q-426, and we found that 0.04 mg ml(-1) DKPs could obviously inhibit the biofilm formation of the strain. DKPs produced by B. amyloliquefaciens Q-426 made a reduction on extracellular polymeric substance (EPS) components, polysaccharides, proteins, DNAs, etc. Real-time PCR was performed to determine that whether DKPs could make an obvious effect on the expression level for genes related to biofilm formation in the strain. The relative expression level of genes tasA, epsH, epsG and remB which related to proteins, extracellular matrix, and polysaccharides, were downregulated with 0.04 mg ml(-1) DKPs, while the expression level of nuclease gene nuc was significantly upregulated. The quantitative results of the mRNA expression level for these genes concerted with the quantitative results on EPS levels. All of the experimental results ultimately indicated that DKPs could inhibit the biofilm formation of the strain B. amyloliquefaciens Q-426.

  10. Analysis of Closely Related Antioxidant Nutraceuticals Using the Green Analytical Methodology of ANN and Smart Spectrophotometric Methods.

    PubMed

    Korany, Mohamed A; Gazy, Azza A; Khamis, Essam F; Ragab, Marwa A A; Kamal, Miranda F

    2017-01-01

    Two new, simple, and specific green analytical methods are proposed: zero-crossing first-derivative and chemometric-based spectrophotometric artificial neural network (ANN). The proposed methods were used for the simultaneous estimation of two closely related antioxidant nutraceuticals, coenzyme Q10 (Q10) and vitamin E, in their mixtures and pharmaceutical preparations. The first method is based on the handling of spectrophotometric data with the first-derivative technique, in which both nutraceuticals were determined in ethanol, each at the zero crossing of the other. The amplitudes of the first-derivative spectra for Q10 and vitamin E were recorded at 285 and 235 nm respectively, and correlated with their concentrations. The linearity ranges of Q10 and vitamin E were 10-60 and 5.6-70 μg⋅mL-1, respectively. The second method, ANN, is a multivariate calibration method and it was developed and applied for the simultaneous determination of both analytes. A training set of 90 different synthetic mixtures containing Q10 and vitamin E in the ranges of 0-100 and 0-556 μg⋅mL-1, respectively, was prepared in ethanol. The absorption spectra of the training set were recorded in the spectral region of 230-300 nm. By relating the concentration sets (x-block) with their corresponding absorption data (y-block), gradient-descent back-propagation ANN calibration could be computed. To validate the proposed network, a set of 45 synthetic mixtures of the two drugs was used. Both proposed methods were successfully applied for the assay of Q10 and vitamin E in their laboratory-prepared mixtures and in their pharmaceutical tablets with excellent recovery. These methods offer advantages over other methods because of low-cost equipment, time-saving measures, and environmentally friendly materials. In addition, no chemical separation prior to analysis was needed. The ANN method was superior to the derivative technique because ANN can determine both drugs under nonlinear experimental conditions. Consequently, ANN would be the method of choice in the routine analysis of Q10 and vitamin E tablets. No interference from common pharmaceutical additives was observed. Student's t-test and the F-test were used to compare the two methods. No significant difference was recorded.

  11. A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal Structures.

    PubMed

    Wootten, Denise; Reynolds, Christopher A; Koole, Cassandra; Smith, Kevin J; Mobarec, Juan C; Simms, John; Quon, Tezz; Coudrat, Thomas; Furness, Sebastian G B; Miller, Laurence J; Christopoulos, Arthur; Sexton, Patrick M

    2016-03-01

    The glucagon-like peptide 1 (GLP-1) receptor is a class B G protein-coupled receptor (GPCR) that is a key target for treatments for type II diabetes and obesity. This receptor, like other class B GPCRs, displays biased agonism, though the physiologic significance of this is yet to be elucidated. Previous work has implicated R2.60(190), N3.43(240), Q7.49(394), and H6.52(363) as key residues involved in peptide-mediated biased agonism, with R2.60(190), N3.43(240), and Q7.49(394) predicted to form a polar interaction network. In this study, we used novel insight gained from recent crystal structures of the transmembrane domains of the glucagon and corticotropin releasing factor 1 (CRF1) receptors to develop improved models of the GLP-1 receptor that predict additional key molecular interactions with these amino acids. We have introduced E6.53(364)A, N3.43(240)Q, Q7.49(394)N, and N3.43(240)Q/Q7.49(394)N mutations to probe the role of predicted H-bonding and charge-charge interactions in driving cAMP, calcium, or extracellular signal-regulated kinase (ERK) signaling. A polar interaction between E6.53(364) and R2.60(190) was predicted to be important for GLP-1- and exendin-4-, but not oxyntomodulin-mediated cAMP formation and also ERK1/2 phosphorylation. In contrast, Q7.49(394), but not R2.60(190)/E6.53(364) was critical for calcium mobilization for all three peptides. Mutation of N3.43(240) and Q7.49(394) had differential effects on individual peptides, providing evidence for molecular differences in activation transition. Collectively, this work expands our understanding of peptide-mediated signaling from the GLP-1 receptor and the key role that the central polar network plays in these events. Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics.

  12. 23 CFR 658.21 - Identification of National Network.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 23 Highways 1 2011-04-01 2011-04-01 false Identification of National Network. 658.21 Section 658... Identification of National Network. (a) To identify the National Network, a State may sign the routes or provide maps of lists of highways describing the National Network. (b) Exceptional local conditions on the...

  13. 23 CFR 658.21 - Identification of National Network.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 23 Highways 1 2010-04-01 2010-04-01 false Identification of National Network. 658.21 Section 658... Identification of National Network. (a) To identify the National Network, a State may sign the routes or provide maps of lists of highways describing the National Network. (b) Exceptional local conditions on the...

  14. 17 CFR 249.308a - Form 10-Q, for quarterly and transition reports under sections 13 or 15(d) of the Securities...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Form 10-Q, for quarterly and... 15(d) of the Securities Exchange Act of 1934 § 249.308a Form 10-Q, for quarterly and transition reports under sections 13 or 15(d) of the Securities Exchange Act of 1934. (a) Form 10-Q shall be used for...

  15. 17 CFR 249.308a - Form 10-Q, for quarterly and transition reports under sections 13 or 15(d) of the Securities...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Form 10-Q, for quarterly and... 15(d) of the Securities Exchange Act of 1934 § 249.308a Form 10-Q, for quarterly and transition reports under sections 13 or 15(d) of the Securities Exchange Act of 1934. (a) Form 10-Q shall be used for...

  16. 17 CFR 249.308a - Form 10-Q, for quarterly and transition reports under sections 13 or 15(d) of the Securities...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 4 2014-04-01 2014-04-01 false Form 10-Q, for quarterly and... 15(d) of the Securities Exchange Act of 1934 § 249.308a Form 10-Q, for quarterly and transition reports under sections 13 or 15(d) of the Securities Exchange Act of 1934. (a) Form 10-Q shall be used for...

  17. 17 CFR 249.308a - Form 10-Q, for quarterly and transition reports under sections 13 or 15(d) of the Securities...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 3 2013-04-01 2013-04-01 false Form 10-Q, for quarterly and... 15(d) of the Securities Exchange Act of 1934 § 249.308a Form 10-Q, for quarterly and transition reports under sections 13 or 15(d) of the Securities Exchange Act of 1934. (a) Form 10-Q shall be used for...

  18. 17 CFR 249.308a - Form 10-Q, for quarterly and transition reports under sections 13 or 15(d) of the Securities...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 3 2012-04-01 2012-04-01 false Form 10-Q, for quarterly and... 15(d) of the Securities Exchange Act of 1934 § 249.308a Form 10-Q, for quarterly and transition reports under sections 13 or 15(d) of the Securities Exchange Act of 1934. (a) Form 10-Q shall be used for...

  19. Secure and Efficient Signature Scheme Based on NTRU for Mobile Payment

    NASA Astrophysics Data System (ADS)

    Xia, Yunhao; You, Lirong; Sun, Zhe; Sun, Zhixin

    2017-10-01

    Mobile payment becomes more and more popular, however the traditional public-key encryption algorithm has higher requirements for hardware which is not suitable for mobile terminals of limited computing resources. In addition, these public-key encryption algorithms do not have the ability of anti-quantum computing. This paper researches public-key encryption algorithm NTRU for quantum computation through analyzing the influence of parameter q and k on the probability of generating reasonable signature value. Two methods are proposed to improve the probability of generating reasonable signature value. Firstly, increase the value of parameter q. Secondly, add the authentication condition that meet the reasonable signature requirements during the signature phase. Experimental results show that the proposed signature scheme can realize the zero leakage of the private key information of the signature value, and increase the probability of generating the reasonable signature value. It also improve rate of the signature, and avoid the invalid signature propagation in the network, but the scheme for parameter selection has certain restrictions.

  20. Reduced ventilation-perfusion (V/Q) mismatch following endobronchial valve insertion demonstrated by Gallium-68 V/Q photon emission tomography/computed tomography.

    PubMed

    Leong, Paul; Le Roux, Pierre-Yves; Callahan, Jason; Siva, Shankar; Hofman, Michael S; Steinfort, Daniel P

    2017-09-01

    Endobronchial valves (EBVs) are increasingly deployed in the management of severe emphysema. Initial studies focussed on volume reduction as the mechanism, with subsequent improvement in forced expiratory volume in 1 s (FEV 1 ). More recent studies have emphasized importance of perfusion on predicting outcomes, though findings have been inconsistent. Gallium-68 ventilation-perfusion (V/Q) photon emission tomography (PET)/computed tomography (CT) is a novel imaging modality with advantages in spatial resolution, quantitation, and speed over conventional V/Q scintigraphy. We report a pilot case in which V/Q-PET/CT demonstrated discordant findings compared with quantitative CT analysis, and directed left lower lobe EBV placement. The patient experienced a significant improvement in 6-min walk distance (6MWD) without change in spirometry. Post-EBV V/Q-PET/CT demonstrated a marked decrease in unmatched (detrimental) V/Q areas and improvement in overall V/Q matching on post-EBV V/Q-PET/CT. These preliminary novel findings suggest that EBVs improve V/Q matching and may explain the observed functional improvements.

  1. Constraining the cosmic deceleration-acceleration transition with type Ia supernova, BAO/CMB and H(z) data

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Santos, M. Vargas dos; Reis, R.R.R.; Waga, I., E-mail: vargas@if.ufrj.br, E-mail: ribamar@if.ufrj.br, E-mail: ioav@if.ufrj.br

    2016-02-01

    We revisit the kink-like parametrization of the deceleration parameter q(z) [1], which considers a transition, at redshift z{sub t}, from cosmic deceleration to acceleration. In this parametrization the initial, at z >> z{sub t}, value of the q-parameter is q{sub i}, its final, z=−1, value is q{sub f} and the duration of the transition is parametrized by τ. By assuming a flat space geometry we obtain constraints on the free parameters of the model using recent data from type Ia supernovae (SN Ia), baryon acoustic oscillations (BAO), cosmic microwave background (CMB) and the Hubble parameter H(z). The use of H(z) data introducesmore » an explicit dependence of the combined likelihood on the present value of the Hubble parameter H{sub 0}, allowing us to explore the influence of different priors when marginalizing over this parameter. We also study the importance of the CMB information in the results by considering data from WMAP7, WMAP9 (Wilkinson Microwave Anisotropy Probe—7 and 9 years) and Planck 2015. We show that the contours and best fit do not depend much on the different CMB data used and that the considered new BAO data is responsible for most of the improvement in the results. Assuming a flat space geometry, q{sub i}=1/2 and expressing the present value of the deceleration parameter q{sub 0} as a function of the other three free parameters, we obtain z{sub t}=0.67{sup +0.10}{sub −0.08}, τ=0.26{sup +0.14}{sub −0.10} and q{sub 0}=−0.48{sup +0.11}{sub −0.13}, at 68% of confidence level, with an uniform prior over H{sub 0}. If in addition we fix q{sub f}=−1, as in flat ΛCDM, DGP and Chaplygin quartessence that are special models described by our parametrization, we get z{sub t}=0.66{sup +0.03}{sub −0.04}, τ=0.33{sup +0.04}{sub −0.04} and q{sub 0}=−0.54{sup +0.05}{sub −0.07}, in excellent agreement with flat ΛCDM for which τ=1/3. We also obtain for flat wCDM, another dark energy model described by our parametrization, the constraint on the equation of state parameter −1.22 < w < −0.78 at more than 99% confidence level.« less

  2. Feedback-Assisted Extension of the Tokamak Operating Space to Low Safety Factor

    NASA Astrophysics Data System (ADS)

    Hanson, J. M.

    2013-10-01

    Recent DIII-D experiments have demonstrated stable operation at very low edge safety factor, q95 <~ 2 through the use of magnetic feedback to control the n = 1 resistive wall mode (RWM) instability. The performance of tokamak fusion devices may benefit from increased plasma current, and thus, decreased q. However, disruptive stability limits are commonly encountered in experiments at qedge ~ 2 (limited plasmas) and q95 ~ 2 (diverted plasmas), limiting exploration of low q regimes. In the recent DIII-D experiments, the impact and control of key disruptive instabilities was studied. Locked n = 1 modes with exponential growth times on the order of the wall eddy current decay timescale τw preceded disruptions at q95 = 2 . The instabilities have a poloidal structure that is consistent with VALEN simulations of the RWM mode structure at q95 = 2 . Applying proportional gain magnetic feedback control of the n = 1 mode resulted in stabilized operation with q95 reaching 1.9, and an extension of the discharge lifetime for > 100τw . Loss of feedback control was accompanied by power supply saturation, followed by a rapidly growing n = 1 mode and disruption. Comparisons of the feedback dynamics with VALEN simulations will be presented. The DIII-D results complement and will be discussed alongside recent RFX-MOD demonstrations of RWM control using magnetic feedback in limited tokamak discharges with qedge < 2. These results call attention to the utility of magnetic feedback in significantly extending the tokamak operational space and potentially opening a new route to economical fusion power production. Supported by the US Department of Energy under DE-FG02-04ER54761 and DE-FC02-04ER54698.

  3. SIR model on a dynamical network and the endemic state of an infectious disease

    NASA Astrophysics Data System (ADS)

    Dottori, M.; Fabricius, G.

    2015-09-01

    In this work we performed a numerical study of an epidemic model that mimics the endemic state of whooping cough in the pre-vaccine era. We considered a stochastic SIR model on dynamical networks that involve local and global contacts among individuals and analysed the influence of the network properties on the characterization of the quasi-stationary state. We computed probability density functions (PDF) for infected fraction of individuals and found that they are well fitted by gamma functions, excepted the tails of the distributions that are q-exponentials. We also computed the fluctuation power spectra of infective time series for different networks. We found that network effects can be partially absorbed by rescaling the rate of infective contacts of the model. An explicit relation between the effective transmission rate of the disease and the correlation of susceptible individuals with their infective nearest neighbours was obtained. This relation quantifies the known screening of infective individuals observed in these networks. We finally discuss the goodness and limitations of the SIR model with homogeneous mixing and parameters taken from epidemiological data to describe the dynamic behaviour observed in the networks studied.

  4. R102Q mutation shifts the salt-bridge network and reduces the structural flexibility of human neuronal calcium sensor-1 protein.

    PubMed

    Zhu, Yuzhen; Wu, Ying; Luo, Yin; Zou, Yu; Ma, Buyong; Zhang, Qingwen

    2014-11-20

    Neuronal calcium sensor-1 (NCS-1) protein has a variety of different neuronal functions and interacts with multiple binding partners mostly through a large solvent-exposed hydrophobic crevice (HC). A single R102Q mutation in human NCS-1 protein was demonstrated to be associated with autism disease. Solution NMR study reported that this R102Q mutant had long-range chemical shift effects on the HC and the C-terminal tail (L3). To understand the influence of the R102Q mutation on the HC and L3 of NCS-1, we have investigated the conformational dynamics and the structural flexibility of wild type (WT) NCS-1 and its R102Q mutant by conducting extensive all-atom molecular dynamics (MD) simulations. On the basis of six independent 450 ns MD simulations, we have found that the R102Q mutation in NCS-1 protein (1) dramatically reduces the flexibility of loops L2 and L3, (2) facilitates L3 in a more extended state to occupy the hydrophobic crevice to a larger extent, (3) significantly affects the intersegment salt bridges, and (4) changes the subspace of the free energy landscape of NCS-1 protein. Analysis of the salt bridge network in both WT and the R102Q variant demonstrates that the R102Q-mutation-induced salt bridge alternations play a critical role on the reduced flexibility of L2 and L3. These results reveal the important role of salt bridges on the structural properties of NCS-1 protein and that R102Q mutation disables the dynamic relocation of C-terminus, which may block the binding of NCS-1 protein to its receptors. This study may provide structural insights into the autistic spectrum disorder associated with R102Q mutation.

  5. Computer Simulation of an Aircraft Seat and Occupant in a Crash Environment. Volume 1. Technical Report

    DTIC Science & Technology

    1983-03-01

    q18 q2 8 q 2 q1 9 = 06q 2 9 812 7 (11)1q0 3 q 2 0 : ś The above coordinates include the Cartesian coordinates of the mass ce-nter of segment 1 ( Xl ...l P0 zC SC Lap Lap belt anchor point ( XL ’ YL’ ZL) 0 Inertial coordinate system Figure 30. Forces acting on occupant torso (nose-down attitude). 87...position calculated by equation (104) for the level flight assumption. The angle is defined according to 0 = sin-- ZL)/ X - XL )2 + (Zp - ZL)2 (106

  6. 17 CFR 249.332 - Form N-Q, quarterly schedule of portfolio holdings of registered management investment company.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Form N-Q, quarterly schedule of portfolio holdings of registered management investment company. 249.332 Section 249.332 Commodity... Securities Exchange Act of 1934 § 249.332 Form N-Q, quarterly schedule of portfolio holdings of registered...

  7. 17 CFR 249.332 - Form N-Q, quarterly schedule of portfolio holdings of registered management investment company.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 3 2012-04-01 2012-04-01 false Form N-Q, quarterly schedule of portfolio holdings of registered management investment company. 249.332 Section 249.332 Commodity... Securities Exchange Act of 1934 § 249.332 Form N-Q, quarterly schedule of portfolio holdings of registered...

  8. 17 CFR 249.332 - Form N-Q, quarterly schedule of portfolio holdings of registered management investment company.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 4 2014-04-01 2014-04-01 false Form N-Q, quarterly schedule of portfolio holdings of registered management investment company. 249.332 Section 249.332 Commodity... Securities Exchange Act of 1934 § 249.332 Form N-Q, quarterly schedule of portfolio holdings of registered...

  9. 17 CFR 249.332 - Form N-Q, quarterly schedule of portfolio holdings of registered management investment company.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 3 2013-04-01 2013-04-01 false Form N-Q, quarterly schedule of portfolio holdings of registered management investment company. 249.332 Section 249.332 Commodity... Securities Exchange Act of 1934 § 249.332 Form N-Q, quarterly schedule of portfolio holdings of registered...

  10. 26 CFR 1.401(a)(9)-6 - Required minimum distributions for defined benefit plans and annuity contracts.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 5 2010-04-01 2010-04-01 false Required minimum distributions for defined...-Sharing, Stock Bonus Plans, Etc. § 1.401(a)(9)-6 Required minimum distributions for defined benefit plans and annuity contracts. Q-1. How must distributions under a defined benefit plan be paid in order to...

  11. Structural Change and Interaction Behavior in Multimodal Networks

    DTIC Science & Technology

    2010-07-30

    S̃q~v = PD( ∑ p Sq→p)− 1 2~v, so λ and D( ∑ p Sq→p) − 1 2~v are an eigenvalue-eigenvector pair for P. By the Perron - Frobenius theorem, we know that λ... Frobenius norm, and α = 11+γ . The closed form solution is F ∗ p→q = (1 − α)(Inq − αS̃q)−1ATp→q [30, 26]. 4 Experiment We evaluated our method for...of mode Xp and the jth cluster of Xq. An approximate factorization is then achieved by minimizing a loss function comprised of the Frobenius norms of

  12. Shadow mechanism and the opposition effect of brightness of atmosphereless celestial bodies

    NASA Astrophysics Data System (ADS)

    Morozhenko, A. V.; Vidmachenko, A. P.

    2013-09-01

    We consider the Irvine-Yanovistkii modification of the shadow model developed by Hapke for the opposition effect of brightness. The relation between the single scattering albedo ω and the transparency coefficient of particles κ is suggested to be used in the form κ = (1 - ω) n, which allows the number of unknowns in the model to be reduced to two parameters (the packing density of particles g and ω) and the single-scattering phase function Ξ(α). The analysis of spectrophotometric measurements of the moon and Mars showed that the data on the observed opposition effect and the changes in the color index with the phase angle α well agree if the values of n = 0.25 and g = 0.4 (the moon) and 0.6 (Mars) are assumed in calculations. When being applied to asteroids of several types, this method also yielded a satisfactory agreement. For the E-type asteroids, the sets of parameters are [g = 0.6, ω = 0.6, A g = 0.21, and q = 0.83] or [g = 0.3, ω = 0.4, A g = 0.15, and q = 0.71] under the Martian single-scattering phase function; for the M-type asteroids, it is [g = 0.4, ω ≤ 0.1, A g ≤ 0.075, and q ≤ 0.42] under the lunar single-scattering phase function; for the S-type asteroids, it is [g = 0.4, ω = 0.4, A g = 0.28, and q = 0.49] under the lunar single-scattering phase function; and for the C-type asteroids, it is [g = 0.6, ω ≤ 0.1, A g ≤ 0.075, and q = 0.43] under the modified lunar single-scattering phase function. The polarization measurements fulfilled by Gehrels et al. (1964) for the bright feature on the lunar surface, Copernicus (L = -20°08', φ = +10°11'), at a phase angle α = 1.6° revealed the deviations in the position of the polarization plane from that typical for the negative branch. They were 22° and 12° in the G and I filters, respectively. At the same time, the deviation was within the error (±3° in the U filter and for the dark feature Plato (L = -10°32', φ = +51°25'), which can be caused by the coherent mechanism of the formation of the polarization peak.

  13. Cardinality enhancement utilizing Sequential Algorithm (SeQ) code in OCDMA system

    NASA Astrophysics Data System (ADS)

    Fazlina, C. A. S.; Rashidi, C. B. M.; Rahman, A. K.; Aljunid, S. A.

    2017-11-01

    Optical Code Division Multiple Access (OCDMA) has been important with increasing demand for high capacity and speed for communication in optical networks because of OCDMA technique high efficiency that can be achieved, hence fibre bandwidth is fully used. In this paper we will focus on Sequential Algorithm (SeQ) code with AND detection technique using Optisystem design tool. The result revealed SeQ code capable to eliminate Multiple Access Interference (MAI) and improve Bit Error Rate (BER), Phase Induced Intensity Noise (PIIN) and orthogonally between users in the system. From the results, SeQ shows good performance of BER and capable to accommodate 190 numbers of simultaneous users contrast with existing code. Thus, SeQ code have enhanced the system about 36% and 111% of FCC and DCS code. In addition, SeQ have good BER performance 10-25 at 155 Mbps in comparison with 622 Mbps, 1 Gbps and 2 Gbps bit rate. From the plot graph, 155 Mbps bit rate is suitable enough speed for FTTH and LAN networks. Resolution can be made based on the superior performance of SeQ code. Thus, these codes will give an opportunity in OCDMA system for better quality of service in an optical access network for future generation's usage

  14. Official Guard and Reserve Manpower Strengths and Statistics, FY 1984 Summary

    DTIC Science & Technology

    1984-01-01

    J 4 1. 4 -A *1u 4 4a M 4 , )MP W% ng P 4 * . 4 (z 4 0 a11 C 4 4 a~~𔃾 7 * 2 04 4pl4~~ 04 *j 4 If N) *z 0 2 .A4 4124 - th - Wi4ý C 4t,404 D 0n ’.4- a...o )U4 Y g o*1 on44 nW v4c nv 4q W .4 4 4.-4 𔃺I ?0 ’~ ~ .pc4.ý% e)0)p)e YW)p)( r nI 4V. D 4 0 a 99 a .4. 1 .1 41. Y Y . q 4C 4 4 4, U.44 CDb 4Y 44 4

  15. Prepubertal Serum Concentrations of Organochlorine Pesticides and Age at Sexual Maturity in Russian Boys.

    PubMed

    Lam, Thuy; Williams, Paige L; Lee, Mary M; Korrick, Susan A; Birnbaum, Linda S; Burns, Jane S; Sergeyev, Oleg; Revich, Boris; Altshul, Larisa M; Patterson, Donald G; Hauser, Russ

    2015-11-01

    Few human studies have evaluated the impact of childhood exposure to organochlorine pesticides (OCP) on pubertal development. We evaluated associations of serum OCP concentrations [hexachlorobenzene (HCB), β-hexachlorocyclohexane (βHCH), and p,p-dichlorodiphenyldichloroethylene (p,p´-DDE)] with age at attainment of sexual maturity among boys. From 2003 through 2005, 350 8- to 9-year-old boys from Chapaevsk, Russia, with measured OCPs were enrolled and followed annually for 8 years. We used multivariable interval-censored models to evaluate associations of OCPs (quartiles) with three physician-assessed measures of sexual maturity: Tanner stage 5 for genitalia growth, Tanner stage 5 for pubic hair growth, or testicular volume (TV) ≥ 20 mL in either testis. In adjusted models, boys with higher HCB concentrations achieved sexual maturity reflected by TV ≥ 20 mL a mean of 3.1 months (95% CI: -1.7, 7.8), 5.3 months (95% CI: 0.6, 10.1), and 5.0 months (95% CI: 0.2, 9.8) later for quartiles Q2, Q3, and Q4, respectively, compared with Q1 (p trend = 0.04). Tanner stage 5 for genitalia growth was attained a mean of 2.2 months (95% CI: -3.1, 7.5), 5.7 months (95% CI: 0.4, 11.0), and 3.7 months (95% CI: -1.7, 9.1) later for quartiles Q2, Q3, and Q4, respectively, of βHCH compared with Q1 (p trend = 0.09). Tanner stage 5 for pubic hair growth occurred 6-9 months later on average for boys in the highest versus lowest quartile for HCB (p trend < 0.001), βHCH (trend p = 0.01), and p,p´-DDE (p trend = 0.04). No associations were observed between p,p´-DDE and Tanner stage 5 for genitalia growth or TV ≥ 20 mL. Higher prepubertal serum HCB and βHCH concentrations were associated with a later age at attainment of sexual maturity. Only the highest quartile of serum p,p´-DDE was associated with later pubic hair maturation. Lam T, Williams PL, Lee MM, Korrick SA, Birnbaum LS, Burns JS, Sergeyev O, Revich B, Altshul LM, Patterson DG Jr, Hauser R. 2015. Prepubertal serum concentrations of organochlorine pesticides and age at sexual maturity in Russian boys. Environ Health Perspect 123:1216-1221; http://dx.doi.org/10.1289/ehp.1409022.

  16. Prepubertal Serum Concentrations of Organochlorine Pesticides and Age at Sexual Maturity in Russian Boys

    PubMed Central

    Lam, Thuy; Williams, Paige L.; Lee, Mary M.; Korrick, Susan A.; Birnbaum, Linda S.; Burns, Jane S.; Sergeyev, Oleg; Revich, Boris; Altshul, Larisa M.; Patterson, Donald G.

    2015-01-01

    Background Few human studies have evaluated the impact of childhood exposure to organochlorine pesticides (OCP) on pubertal development. Objective We evaluated associations of serum OCP concentrations [hexachlorobenzene (HCB), β-hexachlorocyclohexane (βHCH), and p,p-dichlorodiphenyldichloroethylene (p,p´-DDE)] with age at attainment of sexual maturity among boys. Methods From 2003 through 2005, 350 8- to 9-year-old boys from Chapaevsk, Russia, with measured OCPs were enrolled and followed annually for 8 years. We used multivariable interval-censored models to evaluate associations of OCPs (quartiles) with three physician-assessed measures of sexual maturity: Tanner stage 5 for genitalia growth, Tanner stage 5 for pubic hair growth, or testicular volume (TV) ≥ 20 mL in either testis. Results In adjusted models, boys with higher HCB concentrations achieved sexual maturity reflected by TV ≥ 20 mL a mean of 3.1 months (95% CI: –1.7, 7.8), 5.3 months (95% CI: 0.6, 10.1), and 5.0 months (95% CI: 0.2, 9.8) later for quartiles Q2, Q3, and Q4, respectively, compared with Q1 (p trend = 0.04). Tanner stage 5 for genitalia growth was attained a mean of 2.2 months (95% CI: –3.1, 7.5), 5.7 months (95% CI: 0.4, 11.0), and 3.7 months (95% CI: –1.7, 9.1) later for quartiles Q2, Q3, and Q4, respectively, of βHCH compared with Q1 (p trend = 0.09). Tanner stage 5 for pubic hair growth occurred 6–9 months later on average for boys in the highest versus lowest quartile for HCB (p trend < 0.001), βHCH (trend p = 0.01), and p,p´-DDE (p trend = 0.04). No associations were observed between p,p´-DDE and Tanner stage 5 for genitalia growth or TV ≥ 20 mL. Conclusions and relevance Higher prepubertal serum HCB and βHCH concentrations were associated with a later age at attainment of sexual maturity. Only the highest quartile of serum p,p´-DDE was associated with later pubic hair maturation. Citation Lam T, Williams PL, Lee MM, Korrick SA, Birnbaum LS, Burns JS, Sergeyev O, Revich B, Altshul LM, Patterson DG Jr, Hauser R. 2015. Prepubertal serum concentrations of organochlorine pesticides and age at sexual maturity in Russian boys. Environ Health Perspect 123:1216–1221; http://dx.doi.org/10.1289/ehp.1409022 PMID:26009253

  17. 17 CFR 240.13a-13 - Quarterly reports on Form 10-Q (§ 249.308a of this chapter).

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 4 2014-04-01 2014-04-01 false Quarterly reports on Form 10-Q... reports on Form 10-Q (§ 249.308a of this chapter). (a) Except as provided in paragraphs (b) and (c) of... reports on Form 10-K (§ 249.310 of this chapter), shall file a quarterly report on Form 10-Q (§ 249.308a...

  18. 17 CFR 240.13a-13 - Quarterly reports on Form 10-Q (§ 249.308a of this chapter).

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Quarterly reports on Form 10-Q... reports on Form 10-Q (§ 249.308a of this chapter). (a) Except as provided in paragraphs (b) and (c) of... reports on Form 10-K (§ 249.310 of this chapter), shall file a quarterly report on Form 10-Q (§ 249.308a...

  19. 17 CFR 240.13a-13 - Quarterly reports on Form 10-Q (§ 249.308a of this chapter).

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Quarterly reports on Form 10-Q... reports on Form 10-Q (§ 249.308a of this chapter). (a) Except as provided in paragraphs (b) and (c) of... reports on Form 10-K (§ 249.310 of this chapter), shall file a quarterly report on Form 10-Q (§ 249.308a...

  20. 17 CFR 240.13a-13 - Quarterly reports on Form 10-Q (§ 249.308a of this chapter).

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 3 2012-04-01 2012-04-01 false Quarterly reports on Form 10-Q... reports on Form 10-Q (§ 249.308a of this chapter). (a) Except as provided in paragraphs (b) and (c) of... reports on Form 10-K (§ 249.310 of this chapter), shall file a quarterly report on Form 10-Q (§ 249.308a...

  1. 17 CFR 240.13a-13 - Quarterly reports on Form 10-Q (§ 249.308a of this chapter).

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 3 2013-04-01 2013-04-01 false Quarterly reports on Form 10-Q... reports on Form 10-Q (§ 249.308a of this chapter). (a) Except as provided in paragraphs (b) and (c) of... reports on Form 10-K (§ 249.310 of this chapter), shall file a quarterly report on Form 10-Q (§ 249.308a...

  2. Nonparametric Estimation of Distribution and Density Functions with Applications.

    DTIC Science & Technology

    1982-05-01

    8 > Z C.. o i, ,- 4 8 ...S C[ 17 : - j 46 0- IA ~ IL ar’ D rn B- - 4 -4A B- 8 ~a *~jai 188 the jackknife may be found in Gray, et al., and Cressie (Refs 15,28). Analogous to...convergence. 21 =7w; Ul I 0083 q C/) 22S , WJ 8 , J035 224 43 UC I a- 04 14 Q) ’I 4 -4a-Q 23z Let R1 be the real line, the borel field on R 1 and P,

  3. Neighbourhood walkability, daily steps and utilitarian walking in Canadian adults

    PubMed Central

    Hajna, Samantha; Ross, Nancy A; Joseph, Lawrence; Harper, Sam; Dasgupta, Kaberi

    2015-01-01

    Objectives To estimate the associations of neighbourhood walkability (based on Geographic Information System (GIS)-derived measures of street connectivity, land use mix, and population density and the Walk Score) with self-reported utilitarian walking and accelerometer-assessed daily steps in Canadian adults. Design A cross-sectional analysis of data collected as part of the Canadian Health Measures Survey (2007–2009). Setting Home neighbourhoods (500 m polygonal street network buffers around the centroid of the participant's postal code) located in Atlantic Canada, Québec, Ontario, the Prairies and British Columbia. Participants 5605 individuals participated in the survey. 3727 adults (≥18 years) completed a computer-assisted interview and attended a mobile clinic assessment. Analyses were based on those who had complete exposure, outcome and covariate data (n=2949). Main exposure measures GIS-derived walkability (based on land use mix, street connectivity and population density); Walk Score. Main outcome measures Self-reported utilitarian walking; accelerometer-assessed daily steps. Results No important relationship was observed between neighbourhood walkability and daily steps. Participants who reported more utilitarian walking, however, accumulated more steps (<1 h/week: 6613 steps/day, 95% CI 6251 to 6975; 1 to 5 h/week: 6768 steps/day, 95% CI 6420 to 7117; ≥6 h/week: 7391 steps/day, 95% CI 6972 to 7811). There was a positive graded association between walkability and odds of walking ≥1 h/week for utilitarian purposes (eg, Q4 vs Q1 of GIS-derived walkability: OR=1.66, 95% CI 1.31 to 2.11; Q3 vs Q1: OR=1.41, 95% CI 1.14 to 1.76; Q2 vs Q1: OR=1.13, 95% CI 0.91 to 1.39) independent of age, sex, body mass index, married/common law status, annual household income, having children in the household, immigrant status, mood disorder, perceived health, ever smoker and season. Conclusions Contrary to expectations, living in more walkable Canadian neighbourhoods was not associated with more total walking. Utilitarian walking and daily steps were, however, correlated and walkability demonstrated a positive graded relationship with utilitarian walking. PMID:26603246

  4. Development of a Flight Simulation Concept and Aerodynamic Buildup for Investigation of Departure Prevention Systems in Tactical Aircraft.

    DTIC Science & Technology

    1983-09-01

    I - c).Il.- 4 - OIL 1-0 40CA I ..04uLU 1-Z Z ម 00 >O~ 0 CC cc3 0 WCLW X04 g ’"-J0t-0QtcW at Z1--W0Uaow( W" 01- ZZ0Z :3 JCCQ~Aw1-cO 00’-ZI.-0’ Z4... OIL 40 ft.~~L ft t U- U~r ~- b O* - 0 . i 0LL ,;V; 0 O U. W l- oIZ 0U 0 Q W --. " Z-f Ci IL LU - 4 QILL0 - .% 0 (J wU--󈧭- 2 u Q - -JL ZU 0-’ 2 I - w Ow...0 0.440 -0t UI20-.Jc ’A 28.- >.J0Zb4 -JovV-$- UJa 8- C9444L W4-LU 4ao. a L . .4~ 11.0QQ 000002 .U.4’U. z 00".-Po .44in..4 0~4 LUV ., i

  5. Petri-Net Simulations of Communications Networks.

    DTIC Science & Technology

    1980-03-01

    place, althcugh in reality they may be buried several deep. As the total network is conceptualized by the user. he irust betin by mappinp out all oripins...8217 . (choCk~mahes(z*11)!1𔃺’) 957 ockt2(x,y,’nark-,colour);’I 95 elsef 960 if((check~namesrz.Il 1:’) rt(xl405.(v2i"mr) 134 traflloraph.c PaQ * 17 Fri Feb 8...Iaxnctrk+*) l0g0 intbl1.; 164 lirnkgrach.c paq * 19 Fri Feb 8 07:0q:45 1980 1081 in (k[) miot I Iintbi I; 10(42 1 1083 iawoutctr:iolr,1(outtb1l; 1084

  6. Dollar Summary of Prime Contract Awards by Contractor, State or Country, and Place, FY 87. Part 1. 1-Systems, Inc.-Caufield Marine.

    DTIC Science & Technology

    1987-01-01

    4 CY - Z 0 ZI I 0I c I I )Nfl O~C ( >-o P0 q- -400 f6 0-wt mmr M’-f .0)1U6 Ns ID m0t 4 ) 00 - )t )t C c m < ~ -I cv qLn C.. c - 4 -4- 0 n .- 4 W r- 0...8217 aCCA 𔃾)-0 V - 0L A 0 U X00- I V" -4 04C-(A at 0A ID LA LA- - . - 0 0410 1 *j 0- LA 0 I 004 .1 4 -44.40 ’ 4 L -4 >14 -’- -)’ it- 0’L O A N 0’ U. Q- I) q

  7. 17 CFR 274.130 - Form N-Q, quarterly schedule of portfolio holdings of registered management investment company.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 4 2014-04-01 2014-04-01 false Form N-Q, quarterly schedule of portfolio holdings of registered management investment company. 274.130 Section 274.130 Commodity... INVESTMENT COMPANY ACT OF 1940 Forms for Reports § 274.130 Form N-Q, quarterly schedule of portfolio holdings...

  8. 17 CFR 274.130 - Form N-Q, quarterly schedule of portfolio holdings of registered management investment company.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 3 2013-04-01 2013-04-01 false Form N-Q, quarterly schedule of portfolio holdings of registered management investment company. 274.130 Section 274.130 Commodity... INVESTMENT COMPANY ACT OF 1940 Forms for Reports § 274.130 Form N-Q, quarterly schedule of portfolio holdings...

  9. 17 CFR 274.130 - Form N-Q, quarterly schedule of portfolio holdings of registered management investment company.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 3 2012-04-01 2012-04-01 false Form N-Q, quarterly schedule of portfolio holdings of registered management investment company. 274.130 Section 274.130 Commodity... INVESTMENT COMPANY ACT OF 1940 Forms for Reports § 274.130 Form N-Q, quarterly schedule of portfolio holdings...

  10. 17 CFR 274.130 - Form N-Q, quarterly schedule of portfolio holdings of registered management investment company.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Form N-Q, quarterly schedule of portfolio holdings of registered management investment company. 274.130 Section 274.130 Commodity... INVESTMENT COMPANY ACT OF 1940 Forms for Reports § 274.130 Form N-Q, quarterly schedule of portfolio holdings...

  11. Combating Weapons of Mass Destruction: Models, Complexity, and Algorithms in Complex Dynamic and Evolving Networks

    DTIC Science & Technology

    2015-11-01

    NLP Blondel Oslom Infomap 0 0.2 0.4 0.6 0.8 1 0 0.2 0.4 0.6 0.8 1 N M I (N = 5 0 0 0 ) µ SCD SCD- NLP Blondel Oslom Infomap A...Networks with minC ,maxC unconstrained. 0 0.2 0.4 0.6 0.8 1 0 0.2 0.4 0.6 0.8 1 N M I (N = 1 0 0 0 ) µ SCD SCD- NLP Blondel Oslom Infomap 0...0.2 0.4 0.6 0.8 1 0 0.2 0.4 0.6 0.8 1 N M I (N = 5 0 0 0 ) µ SCD SCD- NLP Blondel Oslom Infomap B

  12. Summary of Synoptic Meteorological Observations. Indonesian Coastal Marine Areas. Volume 1. Area 1 - Southeast Sumatra. Area 2 - Christmas Island. Area 3 - Sunda Strait. Area 4 - Northwest Java Sea. Area 5 - Bangka Island Northwest. Area 6 - Natuna Island. Area 7 - Sarawak

    DTIC Science & Technology

    1975-04-01

    AD/ A -006 923 SUMMARY OF SYNOPTIC METEOROLOGICAL OBSERVATIONS. INDONESIAN COASTAL MARINE AREAS. VOLUME I. AREA 1 - SOUTHEAST SUMATRA. AREA 2...Weather Service Command Washington, D. C. April 1975 ;V, A DISTRIBUTED BY: Nausm Tsciulca Iufennls Suvm• U. S. DEPARTMENT OF COMMERCE 2 z z 0 0 ~ > o CI2LI...00 4 bO >~ d) cn q 00 ca (n~ -0E 4) fl) U C 0 E CD o :Cu -V 0. Cau . .t $4 Cu a X k) 04. " # Cu c.. - u 0- u c0 E Q =E 0 ca- 1 ca 4).,u 04$ = a )E ==r

  13. Dispersals of the Siberian Y-chromosome haplogroup Q in Eurasia.

    PubMed

    Huang, Yun-Zhi; Pamjav, Horolma; Flegontov, Pavel; Stenzl, Vlastimil; Wen, Shao-Qing; Tong, Xin-Zhu; Wang, Chuan-Chao; Wang, Ling-Xiang; Wei, Lan-Hai; Gao, Jing-Yi; Jin, Li; Li, Hui

    2018-02-01

    The human Y-chromosome has proven to be a powerful tool for tracing the paternal history of human populations and genealogical ancestors. The human Y-chromosome haplogroup Q is the most frequent haplogroup in the Americas. Previous studies have traced the origin of haplogroup Q to the region around Central Asia and Southern Siberia. Although the diversity of haplogroup Q in the Americas has been studied in detail, investigations on the diffusion of haplogroup Q in Eurasia and Africa are still limited. In this study, we collected 39 samples from China and Russia, investigated 432 samples from previous studies of haplogroup Q, and analyzed the single nucleotide polymorphism (SNP) subclades Q1a1a1-M120, Q1a2a1-L54, Q1a1b-M25, Q1a2-M346, Q1a2a1a2-L804, Q1a2b2-F1161, Q1b1a-M378, and Q1b1a1-L245. Through NETWORK and BATWING analyses, we found that the subclades of haplogroup Q continued to disperse from Central Asia and Southern Siberia during the past 10,000 years. Apart from its migration through the Beringia to the Americas, haplogroup Q also moved from Asia to the south and to the west during the Neolithic period, and subsequently to the whole of Eurasia and part of Africa.

  14. Exploring Social Contextual Correlates of Computer Ownership and Frequency of Use Among Urban, Low-Income, Public Housing Adult Residents

    PubMed Central

    Puleo, Elaine; Bennett, Gary G; Emmons, Karen M

    2007-01-01

    Background As advances in computer access continue to be made, there is a need to better understand the challenges of increasing access for racial/ethnic minorities, particularly among those with lower incomes. Larger social contextual factors, such as social networks and neighborhood factors, may influence computer ownership and the number of places where individuals have access to computers. Objectives We examined the associations of sociodemographic and social contextual factors with computer ownership and frequency of use among 1554 adults living in urban public housing. Methods Bivariate associations between dependent variables (computer ownership and regular computer use) and independent variables were used to build multivariable logistic models adjusted for age and site clusters. Results Participants (N = total weighted size of 2270) were on average 51.0 (± 21.4) years old, primarily African American or Hispanic, and earned less than US $20000 per year. More than half owned a computer, and 42% were regular computer users. Reporting computer ownership was more likely if participants lived above the poverty level (OR = 1.78, 95% CI = 1.39-2.29), completed high school (OR = 2.46, 95% CI = 1.70-3.55), were in financial hardship (OR = 1.38, 95% CI = 1.06-1.81), were employed and supervised others (OR = 1.94, 95% CI = 1.08-3.46), and had multiple role responsibilities (OR = 2.18, 95% CI = 1.31-3.61). Regular computer use was more likely if participants were non-Hispanic (OR = 1.94, 95% CI = 1.30-2.91), lived above the poverty level (OR = 2.84, 95% CI = 1.90-4.24), completed high school (OR = 4.43, 95% CI = 3.04-6.46), were employed and supervised others (OR = 2.41, 95% CI = 1.37-4.22), felt safe in their neighborhood (OR = 1.57, 95% CI = 1.08-2.30), and had greater social network ties (OR = 3.09, 95% CI = 1.26-7.59). Conclusions Disparities in computer ownership and use are narrowing, even among those with very low incomes; however, identifying factors that contribute to disparities in access for these groups will be necessary to ensure the efficacy of future technology-based interventions. A unique finding of our study is that it may be equally as important to consider specific social contextual factors when trying to increase access and use among low-income minorities, such as social network ties, household responsibilities, and neighborhood safety. PMID:18093903

  15. Neural network evaluation of tokamak current profiles for real time control

    NASA Astrophysics Data System (ADS)

    Wróblewski, Dariusz

    1997-02-01

    Active feedback control of the current profile, requiring real-time determination of the current profile parameters, is envisioned for tokamaks operating in enhanced confinement regimes. The distribution of toroidal current in a tokamak is now routinely evaluated based on external (magnetic probes, flux loops) and internal (motional Stark effect) measurements of the poloidal magnetic field. However, the analysis involves reconstruction of magnetohydrodynamic equilibrium and is too intensive computationally to be performed in real time. In the present study, a neural network is used to provide a mapping from the magnetic measurements (internal and external) to selected parameters of the safety factor profile. The single-pass, feedforward calculation of output of a trained neural network is very fast, making this approach particularly suitable for real-time applications. The network was trained on a large set of simulated equilibrium data for the DIII-D tokamak. The database encompasses a large variety of current profiles including the hollow current profiles important for reversed central shear operation. The parameters of safety factor profile (a quantity related to the current profile through the magnetic field tilt angle) estimated by the neural network include central safety factor, q0, minimum value of q, qmin, and the location of qmin. Very good performance of the trained neural network both for simulated test data and for experimental datais demonstrated.

  16. Neural network evaluation of tokamak current profiles for real time control (abstract)

    NASA Astrophysics Data System (ADS)

    Wróblewski, Dariusz

    1997-01-01

    Active feedback control of the current profile, requiring real-time determination of the current profile parameters, is envisioned for tokamaks operating in enhanced confinement regimes. The distribution of toroidal current in a tokamak is now routinely evaluated based on external (magnetic probes, flux loops) and internal (motional Stark effect) measurements of the poloidal magnetic field. However, the analysis involves reconstruction of magnetohydrodynamic equilibrium and is too intensive computationally to be performed in real time. In the present study, a neural network is used to provide a mapping from the magnetic measurements (internal and external) to selected parameters of the safety factor profile. The single-pass, feedforward calculation of output of a trained neural network is very fast, making this approach particularly suitable for real-time applications. The network was trained on a large set of simulated equilibrium data for the DIII-D tokamak. The database encompasses a large variety of current profiles including the hollow current profiles important for reversed central shear operation. The parameters of safety factor profile (a quantity related to the current profile through the magnetic field tilt angle) estimated by the neural network include central safety factor, q0, minimum value of q, qmin, and the location of qmin. Very good performance of the trained neural network both for simulated test data and for experimental data is demonstrated.

  17. 26 CFR 301.6708-1T - Failure to maintain list of investors in potentially abusive tax shelters (temporary).

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Failure to maintain list of investors in... Additional Amounts § 301.6708-1T Failure to maintain list of investors in potentially abusive tax shelters... the penalty for failure to maintain a list of investors in potentially abusive tax shelters. Q-1: What...

  18. Association between glioma susceptibility loci and tumour pathology defines specific molecular etiologies.

    PubMed

    Di Stefano, Anna Luisa; Enciso-Mora, Victor; Marie, Yannick; Desestret, Virginie; Labussière, Marianne; Boisselier, Blandine; Mokhtari, Karima; Idbaih, Ahmed; Hoang-Xuan, Khe; Delattre, Jean-Yves; Houlston, Richard S; Sanson, Marc

    2013-05-01

    Genome-wide association studies have identified single-nucleotide polymorphisms (SNPs) at 7 loci influencing glioma risk: rs2736100 (TERT), rs11979158 and rs2252586 (EGFR), rs4295627 (CCDC26), rs4977756 (CDKN2A/CDKN2B), rs498872 (PHLDB1), and rs6010620 (RTEL1). We studied the relationship among these 7 glioma-risk SNPs and characteristics of tumors from 1374 patients, including grade, IDH (ie IDH1 or IDH2) mutation, EGFR amplification, CDKN2A-p16-INK4a homozygous deletion, 9p and 10q loss, and 1p-19q codeletion. rs2736100 (TERT) and rs6010620 (RTEL1) risk alleles were associated with high-grade disease, EGFR amplification, CDKN2A-p16-INK4a homozygous deletion, and 9p and 10q deletion; rs4295627 (CCDC26) and rs498872 (PHLDB1) were associated with low-grade disease, IDH mutation, and 1p-19q codeletion. In contrast, rs4977756 (CDKN2A/B), rs11979158 (EGFR), and to a lesser extent, rs2252586 (EGFR) risk alleles were independent of tumor grade and genetic profile. Adjusting for tumor grade showed a significant association between rs2736100 and IDH status (P = .01), 10q loss (P = .02); rs4295627 and 1p-19q codeletion (P = .04), rs498872 and IDH (P = .02), 9p loss (P = .04), and 10q loss (P = .02). Case-control analyses stratified into 4 molecular classes (defined by 1p-19q status, IDH mutation, and EGFR amplification) showed an association of rs4295627 and rs498872 with IDH-mutated gliomas (P < 10(-3)) and rs2736100 and rs6010620 with IDH wild-type gliomas (P < 10(-3) and P = .03). The frequency of EGFR and CDKN2A/B risk alleles were largely independent of tumor genetic profile, whereas TERT, RTEL1, CCDC26, and PHLDB1 variants were associated with different genetic profiles that annotate distinct molecular pathways. Our findings provide further insight into the biological basis of glioma etiology.

  19. Microcomputer Network for Computerized Adaptive Testing (CAT)

    DTIC Science & Technology

    1984-03-01

    PRDC TR 84-33 \\Q.�d-33- \\ MICROCOMPUTER NETWOJlt FOR COMPUTERIZED ADAPTIVE TESTING ( CAT ) Baldwin Quan Thomas A . Park Gary Sandahl John H...ACCEIIION NO NPRDC TR 84-33 4. TITLE (-d Sul>tlllo) MICROCOMP UTER NETWORK FOR COMPUTERIZED ADA PTIVE TESTING ( CAT ) 1. Q B. uan T. A . Park...adaptive testing ( CAT ) Bayesian sequential testing 20. ABSTitACT (Continuo on ro•••• aide II noco .. _, _., ld-tlly ,.,. t.loclt _._.) DO Computerized

  20. 47 CFR 0.408 - OMB control numbers and expiration dates assigned pursuant to the Paperwork Reduction Act of 1995.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 05/31/15 3060-0645 Secs. 17.4, 17.48 and 17.49 04/30/15 3060-0647 Cable Price Survey and Supplemental... Licensing of, and Spectrum Usage by, Satellite Network Stations and Space Stations 09/30/13 3060-0685 FCC.../13 3060-0816 FCC 477 04/30/13 3060-0817 Computer III Further Remand Proceedings: BOC Provision of...

  1. 47 CFR 0.408 - OMB control numbers and expiration dates assigned pursuant to the Paperwork Reduction Act of 1995.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 05/31/15 3060-0645 Secs. 17.4, 17.48 and 17.49 04/30/15 3060-0647 Cable Price Survey and Supplemental... Licensing of, and Spectrum Usage by, Satellite Network Stations and Space Stations 09/30/13 3060-0685 FCC.../13 3060-0816 FCC 477 04/30/13 3060-0817 Computer III Further Remand Proceedings: BOC Provision of...

  2. 47 CFR 0.408 - OMB control numbers and expiration dates assigned pursuant to the Paperwork Reduction Act of 1995.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 05/31/15 3060-0645 Secs. 17.4, 17.48 and 17.49 04/30/15 3060-0647 Cable Price Survey and Supplemental... Licensing of, and Spectrum Usage by, Satellite Network Stations and Space Stations 09/30/13 3060-0685 FCC.../13 3060-0816 FCC 477 04/30/13 3060-0817 Computer III Further Remand Proceedings: BOC Provision of...

  3. 26 CFR 54.4980B-9 - Business reorganizations and employer withdrawals from multiemployer plans.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...-9 Business reorganizations and employer withdrawals from multiemployer plans. The following... multiemployer plans: Q-1: For purposes of this section, what are a business reorganization, a stock sale, and an... 26 Internal Revenue 17 2010-04-01 2010-04-01 false Business reorganizations and employer...

  4. Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 9. (H and H Meat Products, Inc.-Iannucci and Son Con.)

    DTIC Science & Technology

    1989-01-01

    8217 Cl - 4 enC )() COOIn-Mi I -4N(r4 N(\\J C C NN N lc04-. >N I 40(00 000 0 (NJ>om -4N(04L) 1 00 CIoOC ’o >0 0 I 20 0 0 Q n4 00 0 L ooQC IM 4(-4 C4 o a oI...1- Q( a ɘ ə a < LA-L-L) < 00(u0N D 0( W1 I’N D (D (DN 41 If 4( c I lle W M.-(--4.1000 U).- 4(D LA- LADO LA4 ( (0C 01.᝴ L -4 - 14-4 I-4 -4 -- of...Mooɜ IftVci 0I oU1 n107,I nL nI nI CaN InC) LALLAALL L -4 1.1Q(0 O C1(1Cim 1000 -00 1 f (D(0 f1 ENc nu nI nu )t nL)I r nI nu O L A L A L A L 10 C -i

  5. Analysis of normal human retinal vascular network architecture using multifractal geometry

    PubMed Central

    Ţălu, Ştefan; Stach, Sebastian; Călugăru, Dan Mihai; Lupaşcu, Carmen Alina; Nicoară, Simona Delia

    2017-01-01

    AIM To apply the multifractal analysis method as a quantitative approach to a comprehensive description of the microvascular network architecture of the normal human retina. METHODS Fifty volunteers were enrolled in this study in the Ophthalmological Clinic of Cluj-Napoca, Romania, between January 2012 and January 2014. A set of 100 segmented and skeletonised human retinal images, corresponding to normal states of the retina were studied. An automatic unsupervised method for retinal vessel segmentation was applied before multifractal analysis. The multifractal analysis of digital retinal images was made with computer algorithms, applying the standard box-counting method. Statistical analyses were performed using the GraphPad InStat software. RESULTS The architecture of normal human retinal microvascular network was able to be described using the multifractal geometry. The average of generalized dimensions (Dq) for q=0, 1, 2, the width of the multifractal spectrum (Δα=αmax − αmin) and the spectrum arms' heights difference (|Δf|) of the normal images were expressed as mean±standard deviation (SD): for segmented versions, D0=1.7014±0.0057; D1=1.6507±0.0058; D2=1.5772±0.0059; Δα=0.92441±0.0085; |Δf|= 0.1453±0.0051; for skeletonised versions, D0=1.6303±0.0051; D1=1.6012±0.0059; D2=1.5531±0.0058; Δα=0.65032±0.0162; |Δf|= 0.0238±0.0161. The average of generalized dimensions (Dq) for q=0, 1, 2, the width of the multifractal spectrum (Δα) and the spectrum arms' heights difference (|Δf|) of the segmented versions was slightly greater than the skeletonised versions. CONCLUSION The multifractal analysis of fundus photographs may be used as a quantitative parameter for the evaluation of the complex three-dimensional structure of the retinal microvasculature as a potential marker for early detection of topological changes associated with retinal diseases. PMID:28393036

  6. Retrieving and routing quantum information in a quantum network

    NASA Astrophysics Data System (ADS)

    Sazim, S.; Chiranjeevi, V.; Chakrabarty, I.; Srinathan, K.

    2015-12-01

    In extant quantum secret sharing protocols, once the secret is shared in a quantum network ( qnet) it cannot be retrieved, even if the dealer wishes that his/her secret no longer be available in the network. For instance, if the dealer is part of the two qnets, say {{Q}}_1 and {{Q}}_2 and he/she subsequently finds that {{Q}}_2 is more reliable than {{Q}}_1, he/she may wish to transfer all her secrets from {{Q}}_1 to {{Q}}_2. Known protocols are inadequate to address such a revocation. In this work we address this problem by designing a protocol that enables the source/dealer to bring back the information shared in the network, if desired. Unlike classical revocation, the no-cloning theorem automatically ensures that the secret is no longer shared in the network. The implications of our results are multi-fold. One interesting implication of our technique is the possibility of routing qubits in asynchronous qnets. By asynchrony we mean that the requisite data/resources are intermittently available (but not necessarily simultaneously) in the qnet. For example, we show that a source S can send quantum information to a destination R even though (a) S and R share no quantum resource, (b) R's identity is unknown to S at the time of sending the message, but is subsequently decided, (c) S herself can be R at a later date and/or in a different location to bequeath her information (`backed-up' in the qnet) and (d) importantly, the path chosen for routing the secret may hit a dead end due to resource constraints, congestion, etc., (therefore the information needs to be back-tracked and sent along an alternate path). Another implication of our technique is the possibility of using insecure resources. For instance, if the quantum memory within an organization is insufficient, it may safely store (using our protocol) its private information with a neighboring organization without (a) revealing critical data to the host and (b) losing control over retrieving the data. Putting the two implications together, namely routing and secure storage, it is possible to envision applications like quantum mail (qmail) as an outsourced service.

  7. Comparing the Performance of Blue Gene/Q with Leading Cray XE6 and InfiniBand Systems

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kerbyson, Darren J.; Barker, Kevin J.; Vishnu, Abhinav

    2013-01-21

    Abstract—Three types of systems dominate the current High Performance Computing landscape: the Cray XE6, the IBM Blue Gene, and commodity clusters using InfiniBand. These systems have quite different characteristics making the choice for a particular deployment difficult. The XE6 uses Cray’s proprietary Gemini 3-D torus interconnect with two nodes at each network endpoint. The latest IBM Blue Gene/Q uses a single socket integrating processor and communication in a 5-D torus network. InfiniBand provides the flexibility of using nodes from many vendors connected in many possible topologies. The performance characteristics of each vary vastly along with their utilization model. In thismore » work we compare the performance of these three systems using a combination of micro-benchmarks and a set of production applications. In particular we discuss the causes of variability in performance across the systems and also quantify where performance is lost using a combination of measurements and models. Our results show that significant performance can be lost in normal production operation of the Cray XT6 and InfiniBand Clusters in comparison to Blue Gene/Q.« less

  8. 26 CFR 301.6231(a)(6)-1 - Computational adjustments.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 18 2013-04-01 2013-04-01 false Computational adjustments. 301.6231(a)(6)-1... Computational adjustments. (a) Changes in a partner's tax liability—(1) In general. A change in the tax... 63 of the Internal Revenue Code is made through a computational adjustment. A computational...

  9. 26 CFR 301.6231(a)(6)-1 - Computational adjustments.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 18 2012-04-01 2012-04-01 false Computational adjustments. 301.6231(a)(6)-1... Computational adjustments. (a) Changes in a partner's tax liability—(1) In general. A change in the tax... 63 of the Internal Revenue Code is made through a computational adjustment. A computational...

  10. 26 CFR 301.6231(a)(6)-1 - Computational adjustments.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 18 2011-04-01 2011-04-01 false Computational adjustments. 301.6231(a)(6)-1... Computational adjustments. (a) Changes in a partner's tax liability—(1) In general. A change in the tax... 63 of the Internal Revenue Code is made through a computational adjustment. A computational...

  11. 26 CFR 301.6231(a)(6)-1 - Computational adjustments.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Computational adjustments. 301.6231(a)(6)-1... Computational adjustments. (a) Changes in a partner's tax liability—(1) In general. A change in the tax... 63 of the Internal Revenue Code is made through a computational adjustment. A computational...

  12. 26 CFR 301.6231(a)(6)-1 - Computational adjustments.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 18 2014-04-01 2014-04-01 false Computational adjustments. 301.6231(a)(6)-1... Computational adjustments. (a) Changes in a partner's tax liability—(1) In general. A change in the tax... 63 of the Internal Revenue Code is made through a computational adjustment. A computational...

  13. Red meat, Mediterranean diet and lung cancer risk among heavy smokers in the COSMOS screening study.

    PubMed

    Gnagnarella, P; Maisonneuve, P; Bellomi, M; Rampinelli, C; Bertolotti, R; Spaggiari, L; Palli, D; Veronesi, G

    2013-10-01

    To assess whether intake of selected foods and food groups and adherence to a Mediterranean diet are associated with lung cancer risk in heavy smokers. In the context of a lung cancer screening programme, we invited asymptomatic volunteers, aged 50 years or more, current smokers or recent quitters, who had smoked at least 20 pack-years, to undergo annual low-dose computed tomography. We assessed participants' diet at baseline using a self-administered food frequency questionnaire and calculated their average daily food intake using an ad hoc computer program and determined their alternate Mediterranean diet (aMED) score. We used Cox proportional hazards regression to assess the association between selected food items, beverages and the aMED score and lung cancer risk. During a mean screening period of 5.7 years, 178 of 4336 participants were diagnosed with lung cancer. At multivariable analysis, red meat consumption was associated with an increased risk of lung cancer [hazard ratio (HR) Q4 versus Q1, 1.73; 95% confidence interval (CI) 1.15-2.61; P-value for trend 0.002], while tea consumption (HR for one or more cup/day versus none, 0.56; 95% CI 0.31-0.99; P-value for trend 0.04) and adherence to a Mediterranean diet (HR for aMED ≥ 8 versus ≤ 1, 0.10; 95% CI 0.01-0.77) were significantly associated with reduced lung cancer risk. Among heavy smokers, high red meat consumption and low adherence to a Mediterranean diet are associated with increased risk of lung cancer.

  14. An approach to collective behavior in cell cultures: modeling and analysis of ECIS data

    NASA Astrophysics Data System (ADS)

    Rabson, David; Lafalce, Evan; Lovelady, Douglas; Lo, Chun-Min

    2011-03-01

    We review recent results in which statistical measures of noise in ECIS data distinguished healthy cell cultures from cancerous or poisoned ones: after subtracting the ``signal,'' the 1 /fα noise in the healthy cultures shows longer short-time and long-time correlations. We discuss application of an artificial neural network to detect the cancer signal, and we demonstrate a computational model of cell-cell communication that produces signals similar to those of the experimental data. The simulation is based on the q -state Potts model with inspiration from the Bak-Tang-Wiesenfeld sand-pile model. We view the level of organization larger than cells but smaller than organs or tissues as a kind of ``mesoscopic'' biological physics, in which few-body interactions dominate, and the experiments and computational model as ways of exploring this regime.

  15. Macronutrient intakes and serum oestrogen, and interaction with polymorphisms in CYP19A1 and HSD17B1 genes: a cross-sectional study in postmenopausal Japanese women.

    PubMed

    Takagi, Sahoko; Naito, Mariko; Kawai, Sayo; Okada, Rieko; Nagata, Chisato; Hosono, Satoyo; Nishida, Yuichiro; Takashima, Naoyuki; Suzuki, Sadao; Shimoshikiryo, Ippei; Mikami, Haruo; Uemura, Hirokazu; Kuriyama, Nagato; Ohnaka, Keizo; Kubo, Michiaki; Hamajima, Nobuyuki; Tanaka, Hideo; Wakai, Kenji

    2017-09-01

    Although higher circulating levels of oestrogen are related to postmenopausal breast cancer risk, limited information is available regarding effects of diet on endogenous oestrogen. Thus, we examined associations between macronutrient intakes and serum oestrogen with consideration of polymorphisms in oestrogen-metabolising genes. In this cross-sectional study, 784 naturally menopaused Japanese women aged 47-69 years were selected from participants of the Japan Multi-Institutional Collaborative Cohort Study. We documented dietary intakes, measured serum concentrations of oestrone (E1) and oestradiol (E2) and genotyped polymorphisms in oestrogen-metabolising CYP19A1 (rs4441215 and rs936306) and HSD17B1 (rs605059) genes. Trends and interactions were examined using linear regression models. In addition, we calculated the ratios of the oestrogen concentrations of the second to the highest quartiles (Q2-Q4) of dietary intake to those of the lowest quartiles (Q1). After adjustment for potential confounders, E2 was significantly associated with intake of carbohydrate and noodles; ratios of Q4 v. Q1 were 1·15 (95 % CI 1·04, 1·28) and 1·15 (95 % CI 1·04, 1·26), respectively. In contrast, E2 levels were inversely associated with intake of total energy, SFA and n-3 highly unsaturated fatty acids (n-3 HUFA); ratios of Q4 v. Q1 were 0·90 (95 % CI 0·82, 0·99), 0·89 (95 % CI 0·81, 0·98) and 0·91 (95 % CI 0·83, 1·00), respectively. In stratified analysis by polymorphisms, the rs605059 genotype of HSD17B1 significantly modified associations of E2 with intake of n-3 HUFA and fish; the associations were limited to those with the CC genotype. Macronutrient intakes were associated with serum E2 level, and these associations may be modified by HSD17B1 polymorphism in postmenopausal women.

  16. Arctic Ice Dynamics Joint Experiment 1975-1976. Physical Oceanography Data Report, Salinity, Temperature and Depth Data, Camp Big Bear. Volume IV.

    DTIC Science & Technology

    1980-02-01

    C to~~~ II qo 3 4 .. ..N~ V. ...... .V . .N N . .S ... .V .fI . i 0 Wi . .... . 53 .O .00... 0--N. .. ZZ W. I -. 0 -z J~~D &Z av F - -q qWe at s-a...q .a1 2c z oft ew dw- lp- eE- W - 0- fP- M .. 1 ,1e mc VftWU 00, 0%0 0000 - P-PtftoO. -%ffE Uqvv 4i . qwE ft . 04W -f ewF-0 wa rnm~~t.- tol Uw0 f E0

  17. Influence on serum asymmetric dimethylarginine (ADMA) concentrations of human paraoxonase 1 polymorphism (Q192R) and exposure to polycyclic aromatic hydrocarbons (PAHs) in Mexican women, a gene-environment interaction.

    PubMed

    Ochoa-Martínez, Ángeles C; Ruíz-Vera, Tania; Almendarez-Reyna, Claudia I; Orta-García, Sandra T; Pérez-Maldonado, Iván N

    2017-11-01

    It has been demonstrated that Cardiovascular Diseases (CVD) are a consequence of the combination of genetic and environmental factors and/or the interaction between them. Therefore, the aim of this study was to evaluate the impact of polycyclic aromatic hydrocarbon (PAHs) exposure and PON1 Q192R polymorphism (genetic susceptibility) on serum asymmetric dimethylarginine (ADMA) levels in Mexican women (n = 206). Urinary 1-hydroxypyrene concentrations (1-OHP; exposure biomarker for PAHs) were quantified using a high-performance liquid chromatography technique, PON1 Q192R polymorphism was genotyped using TaqMan probes and serum ADMA concentrations were evaluated using a commercially available ELISA kit. Urinary 1-OHP levels detected in this study ranged from 0.07 to 9.37 μmol/mol of creatinine (0.13-18.0 μg/g of creatinine). Regarding allele frequency (PON1 Q192R polymorphism), the 192Q-allele frequency was 0.43 and for the 192R-allele it was 0.57. In relation to serum ADMA levels, the levels ranged from 0.06 to 1.46 μmol/L. Moreover, multiple linear regression analysis was performed and associations between urinary 1-OHP levels (β = 0.05, p = 0.002), PON1 Q192R polymorphism (β = 0.04, p = 0.003) and serum ADMA concentrations were found. Besides, an interaction (gene-environment interaction) of both independent variables (1-OHP and PON1 polymorphism) on serum ADMA levels was found (β = 0.04, p = 0.02) in the constructed multiple linear model. Therefore, according to the significance of this research, it is necessary to execute health programs to reduce cardiovascular risk in the assessed population. Copyright © 2017 Elsevier Ltd. All rights reserved.

  18. 47 CFR Alphabetical Index - Part 76

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ...: Notification 76.94 Network programming 76.5 Network programs: nonduplication protection 76.92 Network station....209 Possession of rules 76.301 Prime time 76.5 Program carriages, STV 76.64 Programming, Network 76.5... candidates for 76.205 PURPOSE—Part 76 76.1 Q Qualified TV station, Showing 76.55 R Rate regulation standards...

  19. All Prime Contract Awards by State or Country, Place, and Contractor, Fiscal Year 1985. Part 20 (Antilles - Israel).

    DTIC Science & Technology

    1985-01-01

    0 5 c0 (0o A I L o t eMMC . r nC)McI- LJJJJ Lntr n00L )0C nL nF- M~ N Coc 4cNV 1 4Q - 4- - 4- 4- 444) - 4 4- 4 -4 ( 0 00 0 - 4- o - c0 c nS < I 6...8217 0 : (04-4 0 .-4 O-4-4 0 .- 0 -4 0 -4 ov owl OM O-4 0 -4 D. 0 -4 * O 𔃾 -1 04 0 4 04 04 0 4 04 0 4 1 41 04 10 1 -4 N 0N N 0 N 0n N NNN0 I 0 LL om 5 - .4-4 0 ...an) -1 00 N 10) 044( < in4 n (D 0 F- ) 400 04 N-

  20. Genetic Predisposition to In Situ and Invasive Lobular Carcinoma of the Breast

    PubMed Central

    Petridis, Christos; Brook, Mark N.; Nowinski, Salpie; Papouli, Efterpi; Fletcher, Olivia; Pinder, Sarah; Hanby, Andrew; Kohut, Kelly; Gorman, Patricia; Caneppele, Michele; Peto, Julian; dos Santos Silva, Isabel; Johnson, Nichola; Swann, Ruth; Dwek, Miriam; Perkins, Katherine-Anne; Gillett, Cheryl; Houlston, Richard; Ross, Gillian; De Ieso, Paolo; Southey, Melissa C.; Hopper, John L.; Provenzano, Elena; Apicella, Carmel; Wesseling, Jelle; Cornelissen, Sten; Keeman, Renske; Fasching, Peter A.; Jud, Sebastian M.; Ekici, Arif B.; Beckmann, Matthias W.; Kerin, Michael J.; Marme, Federick; Schneeweiss, Andreas; Sohn, Christof; Burwinkel, Barbara; Guénel, Pascal; Truong, Therese; Laurent-Puig, Pierre; Kerbrat, Pierre; Bojesen, Stig E.; Nordestgaard, Børge G.; Nielsen, Sune F.; Flyger, Henrik; Milne, Roger L.; Perez, Jose Ignacio Arias; Menéndez, Primitiva; Benitez, Javier; Brenner, Hermann; Dieffenbach, Aida Karina; Arndt, Volker; Stegmaier, Christa; Meindl, Alfons; Lichtner, Peter; Schmutzler, Rita K.; Lochmann, Magdalena; Brauch, Hiltrud; Fischer, Hans-Peter; Ko, Yon-Dschun; Nevanlinna, Heli; Muranen, Taru A.; Aittomäki, Kristiina; Blomqvist, Carl; Bogdanova, Natalia V.; Dörk, Thilo; Lindblom, Annika; Margolin, Sara; Mannermaa, Arto; Kataja, Vesa; Kosma, Veli-Matti; Hartikainen, Jaana M.; Chenevix-Trench, Georgia; Investigators, kConFab; Lambrechts, Diether; Weltens, Caroline; Van Limbergen, Erik; Hatse, Sigrid; Chang-Claude, Jenny; Rudolph, Anja; Seibold, Petra; Flesch-Janys, Dieter; Radice, Paolo; Peterlongo, Paolo; Bonanni, Bernardo; Volorio, Sara; Giles, Graham G.; Severi, Gianluca; Baglietto, Laura; Mclean, Catriona A.; Haiman, Christopher A.; Henderson, Brian E.; Schumacher, Fredrick; Le Marchand, Loic; Simard, Jacques; Goldberg, Mark S.; Labrèche, France; Dumont, Martine; Kristensen, Vessela; Winqvist, Robert; Pylkäs, Katri; Jukkola-Vuorinen, Arja; Kauppila, Saila; Andrulis, Irene L.; Knight, Julia A.; Glendon, Gord; Mulligan, Anna Marie; Devillee, Peter; Tollenaar, Rob A. E. M.; Seynaeve, Caroline M.; Kriege, Mieke; Figueroa, Jonine; Chanock, Stephen J.; Sherman, Mark E.; Hooning, Maartje J.; Hollestelle, Antoinette; van den Ouweland, Ans M. W.; van Deurzen, Carolien H. M.; Li, Jingmei; Czene, Kamila; Humphreys, Keith; Cox, Angela; Cross, Simon S.; Reed, Malcolm W. R.; Shah, Mitul; Jakubowska, Anna; Lubinski, Jan; Jaworska-Bieniek, Katarzyna; Durda, Katarzyna; Swerdlow, Anthony; Ashworth, Alan; Orr, Nicholas; Schoemaker, Minouk; Couch, Fergus J.; Hallberg, Emily; González-Neira, Anna; Pita, Guillermo; Alonso, M. Rosario; Tessier, Daniel C.; Vincent, Daniel; Bacot, Francois; Bolla, Manjeet K.; Wang, Qin; Dennis, Joe; Michailidou, Kyriaki; Dunning, Alison M.; Hall, Per; Easton, Doug; Pharoah, Paul; Schmidt, Marjanka K.; Tomlinson, Ian; Garcia-Closas, Montserrat

    2014-01-01

    Invasive lobular breast cancer (ILC) accounts for 10–15% of all invasive breast carcinomas. It is generally ER positive (ER+) and often associated with lobular carcinoma in situ (LCIS). Genome-wide association studies have identified more than 70 common polymorphisms that predispose to breast cancer, but these studies included predominantly ductal (IDC) carcinomas. To identify novel common polymorphisms that predispose to ILC and LCIS, we pooled data from 6,023 cases (5,622 ILC, 401 pure LCIS) and 34,271 controls from 36 studies genotyped using the iCOGS chip. Six novel SNPs most strongly associated with ILC/LCIS in the pooled analysis were genotyped in a further 516 lobular cases (482 ILC, 36 LCIS) and 1,467 controls. These analyses identified a lobular-specific SNP at 7q34 (rs11977670, OR (95%CI) for ILC = 1.13 (1.09–1.18), P = 6.0×10−10; P-het for ILC vs IDC ER+ tumors = 1.8×10−4). Of the 75 known breast cancer polymorphisms that were genotyped, 56 were associated with ILC and 15 with LCIS at P<0.05. Two SNPs showed significantly stronger associations for ILC than LCIS (rs2981579/10q26/FGFR2, P-het = 0.04 and rs889312/5q11/MAP3K1, P-het = 0.03); and two showed stronger associations for LCIS than ILC (rs6678914/1q32/LGR6, P-het = 0.001 and rs1752911/6q14, P-het = 0.04). In addition, seven of the 75 known loci showed significant differences between ER+ tumors with IDC and ILC histology, three of these showing stronger associations for ILC (rs11249433/1p11, rs2981579/10q26/FGFR2 and rs10995190/10q21/ZNF365) and four associated only with IDC (5p12/rs10941679; rs2588809/14q24/RAD51L1, rs6472903/8q21 and rs1550623/2q31/CDCA7). In conclusion, we have identified one novel lobular breast cancer specific predisposition polymorphism at 7q34, and shown for the first time that common breast cancer polymorphisms predispose to LCIS. We have shown that many of the ER+ breast cancer predisposition loci also predispose to ILC, although there is some heterogeneity between ER+ lobular and ER+ IDC tumors. These data provide evidence for overlapping, but distinct etiological pathways within ER+ breast cancer between morphological subtypes. PMID:24743323

  1. Coordination sequences and information spreading in small-world networks

    NASA Astrophysics Data System (ADS)

    Herrero, Carlos P.

    2002-10-01

    We study the spread of information in small-world networks generated from different d-dimensional regular lattices, with d=1, 2, and 3. With this purpose, we analyze by numerical simulations the behavior of the coordination sequence, e.g., the average number of sites C(n) that can be reached from a given node of the network in n steps along its bonds. For sufficiently large networks, we find an asymptotic behavior C(n)~ρn, with a constant ρ that depends on the network dimension d and on the rewiring probability p (which measures the disorder strength of a given network). A simple model of information spreading in these networks is studied, assuming that only a fraction q of the network sites are active. The number of active nodes reached in n steps has an asymptotic form λn, λ being a constant that depends on p and q, as well as on the dimension d of the underlying lattice. The information spreading presents two different regimes depending on the value of λ: For λ>1 the information propagates along the whole system, and for λ<1 the spreading is damped and the information remains confined in a limited region of the network. We discuss the connection of these results with site percolation in small-world networks.

  2. The amplitude and spectral index of the large angular scale anisotropy in the cosmic microwave background radiation

    NASA Technical Reports Server (NTRS)

    Ganga, Ken; Page, Lyman; Cheng, Edward; Meyer, Stephan

    1994-01-01

    In many cosmological models, the large angular scale anisotropy in the cosmic microwave background is parameterized by a spectral index, n, and a quadrupolar amplitude, Q. For a Harrison-Peebles-Zel'dovich spectrum, n = 1. Using data from the Far Infrared Survey (FIRS) and a new statistical measure, a contour plot of the likelihood for cosmological models for which -1 less than n less than 3 and 0 equal to or less than Q equal to or less than 50 micro K is obtained. Depending upon the details of the analysis, the maximum likelihood occurs at n between 0.8 and 1.4 and Q between 18 and 21 micro K. Regardless of Q, the likelihood is always less than half its maximum for n less than -0.4 and for n greater than 2.2, as it is for Q less than 8 micro K and Q greater than 44 micro K.

  3. Role of mitochondrial electron transport complex I in coenzyme Q1 reduction by intact pulmonary arterial endothelial cells and the effect of hyperoxia.

    PubMed

    Merker, Marilyn P; Audi, Said H; Lindemer, Brian J; Krenz, Gary S; Bongard, Robert D

    2007-09-01

    The objective was to determine the impact of intact normoxic and hyperoxia-exposed (95% O(2) for 48 h) bovine pulmonary arterial endothelial cells in culture on the redox status of the coenzyme Q(10) homolog coenzyme Q(1) (CoQ(1)). When CoQ(1) (50 microM) was incubated with the cells for 30 min, its concentration in the medium decreased over time, reaching a lower level for normoxic than hyperoxia-exposed cells. The decreases in CoQ(1) concentration were associated with generation of CoQ(1) hydroquinone (CoQ(1)H(2)), wherein 3.4 times more CoQ(1)H(2) was produced in the normoxic than hyperoxia-exposed cell medium (8.2 +/- 0.3 and 2.4 +/- 0.4 microM, means +/- SE, respectively) after 30 min. The maximum CoQ(1) reduction rate for the hyperoxia-exposed cells, measured using the cell membrane-impermeant redox indicator potassium ferricyanide, was about one-half that of normoxic cells (11.4 and 24.1 nmol x min(-1) x mg(-1) cell protein, respectively). The mitochondrial electron transport complex I inhibitor rotenone decreased the CoQ(1) reduction rate by 85% in the normoxic cells and 44% in the hyperoxia-exposed cells. There was little or no inhibitory effect of NAD(P)H:quinone oxidoreductase 1 (NQO1) inhibitors on CoQ(1) reduction. Intact cell oxygen consumption rates and complex I activities in mitochondria-enriched fractions were also lower for hyperoxia-exposed than normoxic cells. The implication is that intact pulmonary endothelial cells influence the redox status of CoQ(1) via complex I-mediated reduction to CoQ(1)H(2), which appears in the extracellular medium, and that the hyperoxic exposure decreases the overall CoQ(1) reduction capacity via a depression in complex I activity.

  4. Whole-Genome Sequencing Suggests Schizophrenia Risk Mechanisms in Humans with 22q11.2 Deletion Syndrome.

    PubMed

    Merico, Daniele; Zarrei, Mehdi; Costain, Gregory; Ogura, Lucas; Alipanahi, Babak; Gazzellone, Matthew J; Butcher, Nancy J; Thiruvahindrapuram, Bhooma; Nalpathamkalam, Thomas; Chow, Eva W C; Andrade, Danielle M; Frey, Brendan J; Marshall, Christian R; Scherer, Stephen W; Bassett, Anne S

    2015-09-16

    Chromosome 22q11.2 microdeletions impart a high but incomplete risk for schizophrenia. Possible mechanisms include genome-wide effects of DGCR8 haploinsufficiency. In a proof-of-principle study to assess the power of this model, we used high-quality, whole-genome sequencing of nine individuals with 22q11.2 deletions and extreme phenotypes (schizophrenia, or no psychotic disorder at age >50 years). The schizophrenia group had a greater burden of rare, damaging variants impacting protein-coding neurofunctional genes, including genes involved in neuron projection (nominal P = 0.02, joint burden of three variant types). Variants in the intact 22q11.2 region were not major contributors. Restricting to genes affected by a DGCR8 mechanism tended to amplify between-group differences. Damaging variants in highly conserved long intergenic noncoding RNA genes also were enriched in the schizophrenia group (nominal P = 0.04). The findings support the 22q11.2 deletion model as a threshold-lowering first hit for schizophrenia risk. If applied to a larger and thus better-powered cohort, this appears to be a promising approach to identify genome-wide rare variants in coding and noncoding sequence that perturb gene networks relevant to idiopathic schizophrenia. Similarly designed studies exploiting genetic models may prove useful to help delineate the genetic architecture of other complex phenotypes. Copyright © 2015 Merico et al.

  5. Whole-Genome Sequencing Suggests Schizophrenia Risk Mechanisms in Humans with 22q11.2 Deletion Syndrome

    PubMed Central

    Merico, Daniele; Zarrei, Mehdi; Costain, Gregory; Ogura, Lucas; Alipanahi, Babak; Gazzellone, Matthew J.; Butcher, Nancy J.; Thiruvahindrapuram, Bhooma; Nalpathamkalam, Thomas; Chow, Eva W. C.; Andrade, Danielle M.; Frey, Brendan J.; Marshall, Christian R.; Scherer, Stephen W.; Bassett, Anne S.

    2015-01-01

    Chromosome 22q11.2 microdeletions impart a high but incomplete risk for schizophrenia. Possible mechanisms include genome-wide effects of DGCR8 haploinsufficiency. In a proof-of-principle study to assess the power of this model, we used high-quality, whole-genome sequencing of nine individuals with 22q11.2 deletions and extreme phenotypes (schizophrenia, or no psychotic disorder at age >50 years). The schizophrenia group had a greater burden of rare, damaging variants impacting protein-coding neurofunctional genes, including genes involved in neuron projection (nominal P = 0.02, joint burden of three variant types). Variants in the intact 22q11.2 region were not major contributors. Restricting to genes affected by a DGCR8 mechanism tended to amplify between-group differences. Damaging variants in highly conserved long intergenic noncoding RNA genes also were enriched in the schizophrenia group (nominal P = 0.04). The findings support the 22q11.2 deletion model as a threshold-lowering first hit for schizophrenia risk. If applied to a larger and thus better-powered cohort, this appears to be a promising approach to identify genome-wide rare variants in coding and noncoding sequence that perturb gene networks relevant to idiopathic schizophrenia. Similarly designed studies exploiting genetic models may prove useful to help delineate the genetic architecture of other complex phenotypes. PMID:26384369

  6. Assessment of Bias in the National Mosaic and Multi-Sensor QPE (NMQ/Q2) Reanalysis Radar-Only Estimate

    NASA Astrophysics Data System (ADS)

    Nelson, B. R.; Prat, O. P.; Stevens, S. E.; Seo, D. J.; Zhang, J.; Howard, K.

    2014-12-01

    The processing of radar-only precipitation via the reanalysis from the National Mosaic and Multi-Sensor QPE (NMQ/Q2) based on the WSR-88D Next-generation Radar (NEXRAD) network over Continental United States (CONUS) is nearly completed for the period covering from 2001 to 2012. Reanalysis data are available at 1-km and 5-minute resolution. An important step in generating the best possible precipitation data is to assess the bias in the radar-only product. In this work, we use data from a combination of rain gauge networks to assess the bias in the NMQ reanalysis. Rain gauge networks such as the Hydrometeorological Automated Data System (HADS), the Automated Surface Observing Systems (ASOS), the Climate Reference Network (CRN), and the Global Historical Climatology Network Daily (GHCN-D) are combined for use in the assessment. These rain gauge networks vary in spatial density and temporal resolution. The challenge hence is to optimally utilize them to assess the bias at the finest resolution possible. For initial assessment, we propose to subset the CONUS data in climatologically representative domains, and perform bias assessment using information in the Q2 dataset on precipitation type and phase.

  7. Computation of ventilation-perfusion ratio with Kr-81m in pulmonary embolism

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Meignan, M.; Simonneau, G.; Oliveira, L.

    1984-02-01

    Diagnostic difficulties occur in pulmonary embolism (PE) during visual analysis of ventilation-perfusion images in matched defects or in chronic obstructive lung disease (COPD). In 44 patients with angiographically confirmed PE and in 40 patients with COPD, the regional ventilation-perfusion ratios (V/Q) were therefore computed using krypton-81m for each perfusion defect, and were displayed in a functional image. In patients with PE and mismatched defects, a high V/Q (1.96) was observed. A V/Q > 1.25 was also found in nine of 11 patients having PE and indeterminate studies (studies with perfusion abnormalities matched by radiographic abnormalities). COPD was characterized by matchedmore » defects and low V/Q. The percentage of patients correctly classified as having PE or COPD increased from 56% when considering the match or mismatched character to 88% when based on a V/Q of 1.25 in the region of the perfusion defect. This quantitative analysis, therefore, seems useful in classifying patients with scintigraphic suspicion of PE.« less

  8. All Prime Contract Awards by State or Country, Place, and Contractor, FY 88. Part 9. (Athens, Maine-Woodbine, Maryland).

    DTIC Science & Technology

    1988-01-01

    Mon MOlA mIooo (00 (000000 (0 00 (0 (000 (0000000000 IW001(mo(0 W00000000 (00 WO000 mo00 mo00 000000000 I(00LA41 0 0000000 0 000 00 00 000000000(fl(0LA4...tv. - 4- 4 4q r.4q 444l 4q. vC .Ct .44v 4444-4av T-a8 MOLA (0 I -(1N4NN l -N j -NN 4N 04 NNNNNN 0 "CVNN NN N N NNN NN4N0 4CJC- ~ l V"N N "N N I(Oin< wL...4 0"t -0 󈧈 44444 -04 V0 𔃾 V V 0I (00InCO i cNNNNN"~ CN EN EN C4NNNN cN .N .N .ENl 1 l cc c cC c0 0 1 (00In< i V00000 -4 0 to Ln MOLA M ’Wn Ln on n

  9. Genetic variants of 17q21 are associated with childhood-onset asthma and related phenotypes in a northeastern Han Chinese population: a case-control study.

    PubMed

    Yu, X; Yu, C; Ren, Z; Deng, Y; Song, J; Zhang, H; Zhou, H

    2014-05-01

    A genome-wide association study (GWAS) suggested that variants on chromosome 17q21 were associated with childhood-onset asthma in white populations. Two replication studies had been conducted in southern Han Chinese population in 2009 and 2012. However, these two Chinese replication results were inconsistent. To further confirm the role of 17q21 common variants, an association study of 17q21 single nucleotide polymorphisms (SNPs) with the risk of childhood-onset asthma was performed in a Han population from northeastern China. In this study, rs3894194, rs12603332 and rs11650680 were genotyped in 435 asthmatic children and 601 healthy controls by using a SNaPshot method. Our data showed that the allelic frequency of rs12603332 and rs11650680 showed significant differences between asthmatic cases and healthy controls, with an odds ratio (OR) of 1.36 [95% confidence interval (CI) 1.12-1.65, P=0.002] and an OR of 1.36 (95% CI 1.07-1.74, P=0.01). Genotype distribution analysis also showed the significant associations of the above two loci with childhood asthma under dominant, recessive and additive model (dominant OR=1.57, 95% CI 1.04-2.36, P=0.032; recessive OR=1.41, 95% CI 1.09-1.83, P=0.009; additive OR=1.97, 95% CI 1.24-3.14, P=0.004; recessive OR=1.50, 95% CI 1.13-1.98, P=0.005). Besides, linear regression analysis showed that rs3894194 and rs12603332 were also significantly associated with asthma phenotypes such as log10 -transformed immunoglobulin E (IgE) level (IU/ml) and log10 -transformed eosinophil percentage (dominant, P=0.04; additive, P=0.01; recessive, P=0.04; recessive, P=0.03; additive, P=0.02). Collectively, our findings suggest that orosomucoid 1-like 3 (ORMDL3) locus on chromosome 17q21 is a risk factor for childhood-onset asthma in northeastern Han Chinese population. Further studies will be needed to elucidate the pathogenesis that ORMDL3 locus predisposes to childhood-onset asthma. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  10. Phenotypic and Molecular Convergence of 2q23.1 Deletion Syndrome with Other Neurodevelopmental Syndromes Associated with Autism Spectrum Disorder

    PubMed Central

    Mullegama, Sureni V.; Alaimo, Joseph T.; Chen, Li; Elsea, Sarah H.

    2015-01-01

    Roughly 20% of autism spectrum disorders (ASD) are syndromic with a well-established genetic cause. Studying the genes involved can provide insight into the molecular and cellular mechanisms of ASD. 2q23.1 deletion syndrome (causative gene, MBD5) is a recently identified genetic neurodevelopmental disorder associated with ASD. Mutations in MBD5 have been found in ASD cohorts. In this study, we provide a phenotypic update on the prevalent features of 2q23.1 deletion syndrome, which include severe intellectual disability, seizures, significant speech impairment, sleep disturbance, and autistic-like behavioral problems. Next, we examined the phenotypic, molecular, and network/pathway relationships between nine neurodevelopmental disorders associated with ASD: 2q23.1 deletion Rett, Angelman, Pitt-Hopkins, 2q23.1 duplication, 5q14.3 deletion, Kleefstra, Kabuki make-up, and Smith-Magenis syndromes. We show phenotypic overlaps consisting of intellectual disability, speech delay, seizures, sleep disturbance, hypotonia, and autistic-like behaviors. Molecularly, MBD5 possibly regulates the expression of UBE3A, TCF4, MEF2C, EHMT1 and RAI1. Network analysis reveals that there could be indirect protein interactions, further implicating function for these genes in common pathways. Further, we show that when MBD5 and RAI1 are haploinsufficient, they perturb several common pathways that are linked to neuronal and behavioral development. These findings support further investigations into the molecular and pathway relationships among genes linked to neurodevelopmental disorders and ASD, which will hopefully lead to common points of regulation that may be targeted toward therapeutic intervention. PMID:25853262

  11. Controlled release of cavity states into propagating modes induced via a single qubit

    NASA Astrophysics Data System (ADS)

    Pfaff, Wolfgang; Constantin, Marius; Reagor, Matthew; Axline, Christopher; Blumoff, Jacob; Chou, Kevin; Leghtas, Zaki; Touzard, Steven; Heeres, Reinier; Reinhold, Philip; Ofek, Nissim; Sliwa, Katrina; Frunzio, Luigi; Mirrahimi, Mazyar; Lehnert, Konrad; Jiang, Liang; Devoret, Michel; Schoelkopf, Robert

    Photonic states stored in long-lived cavities are a promising platform for scalable quantum computing and for the realization of quantum networks. An important aspect in such a cavity-based architecture will be the controlled conversion of stored photonic states into propagating ones. This will allow, for instance, quantum state transfer between remote cavities. We demonstrate the controlled release of quantum states from a microwave resonator with millisecond lifetime in a 3D circuit QED system. Dispersive coupling of the cavity to a transmon qubit allows us to enable a four-wave mixing process that transfers the stored state into a second resonator from which it can leave the system through a transmission line. This permits us to evacuate the cavity on time scales that are orders of magnitude faster than the intrinsic lifetime. This Q-switching process can in principle be fully coherent, making our system highly promising for quantum state transfer between nodes in a quantum network of high-Q cavities.

  12. Ideal Compliant Joints and Integration of Computer Aided Design and Analysis

    DTIC Science & Technology

    2013-11-17

    coordinates as dxEIEA U l x xe ][ 0 T                eee Q     . (9) In the computer...generalized damping force can be written as dxIA x l x x )) 21 (( 2 0 1 d ee Q

  13. 26 CFR 1.125-3 - Effect of the Family and Medical Leave Act (FMLA) on the operation of cafeteria plans.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 2 2014-04-01 2014-04-01 false Effect of the Family and Medical Leave Act (FMLA... Specifically Excluded from Gross Income § 1.125-3 Effect of the Family and Medical Leave Act (FMLA) on the... Family and Medical Leave Act (FMLA), 29 U.S.C. 2601 et seq., on the operation of cafeteria plans: Q-1...

  14. 26 CFR 1.125-3 - Effect of the Family and Medical Leave Act (FMLA) on the operation of cafeteria plans.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 2 2012-04-01 2012-04-01 false Effect of the Family and Medical Leave Act (FMLA... Specifically Excluded from Gross Income § 1.125-3 Effect of the Family and Medical Leave Act (FMLA) on the... Family and Medical Leave Act (FMLA), 29 U.S.C. 2601 et seq., on the operation of cafeteria plans: Q-1...

  15. 26 CFR 1.125-3 - Effect of the Family and Medical Leave Act (FMLA) on the operation of cafeteria plans.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 2 2013-04-01 2013-04-01 false Effect of the Family and Medical Leave Act (FMLA... Specifically Excluded from Gross Income § 1.125-3 Effect of the Family and Medical Leave Act (FMLA) on the... Family and Medical Leave Act (FMLA), 29 U.S.C. 2601 et seq., on the operation of cafeteria plans: Q-1...

  16. 26 CFR 1.125-3 - Effect of the Family and Medical Leave Act (FMLA) on the operation of cafeteria plans.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 2 2011-04-01 2011-04-01 false Effect of the Family and Medical Leave Act (FMLA... Specifically Excluded from Gross Income § 1.125-3 Effect of the Family and Medical Leave Act (FMLA) on the... Family and Medical Leave Act (FMLA), 29 U.S.C. 2601 et seq., on the operation of cafeteria plans: Q-1...

  17. All Prime Contract Awards by State or Country, Place and Contractor. Part 19. (Abbot, Virginia-Yorktown, Virginia)

    DTIC Science & Technology

    1989-01-01

    C C.CV)i 17)0 4*0 1"-ooO 0 ooOO0-0oooO0 00 1-NN W on XIIOI0 0-4 of4( NOwO (004000a . w 000) -400) 0) 0) )0) 0) 0)0(4 ) )0)0 CY ( -4 00Q WC> Co- if < 1...11 04 0-4 --- C’m 0)-4 ?.-4 0)00tMo (D C𔃾 ONN -*-* 0C’)I i W11< 347 ) 61IC-N -4NNN"NN 0-4 LO -4 4 -4 00.4-4 t-- 4 -4 -4 -4 Ni-4 -4 a) 0 011-01 <m’ t 𔃽r

  18. Iterative Demodulation and Decoding of Non-Square QAM

    NASA Technical Reports Server (NTRS)

    Li, Lifang; Divsalar, Dariush; Dolinar, Samuel

    2004-01-01

    It has been shown that a non-square (NS) 2(sup 2n+1)-ary (where n is a positive integer) quadrature amplitude modulation [(NS)2(sup 2n+1)-QAM] has inherent memory that can be exploited to obtain coding gains. Moreover, it should not be necessary to build new hardware to realize these gains. The present scheme is a product of theoretical calculations directed toward reducing the computational complexity of decoding coded 2(sup 2n+1)-QAM. In the general case of 2(sup 2n+1)-QAM, the signal constellation is not square and it is impossible to have independent in-phase (I) and quadrature-phase (Q) mapping and demapping. However, independent I and Q mapping and demapping are desirable for reducing the complexity of computing the log likelihood ratio (LLR) between a bit and a received symbol (such computations are essential operations in iterative decoding). This is because in modulation schemes that include independent I and Q mapping and demapping, each bit of a signal point is involved in only one-dimensional mapping and demapping. As a result, the computation of the LLR is equivalent to that of a one-dimensional pulse amplitude modulation (PAM) system. Therefore, it is desirable to find a signal constellation that enables independent I and Q mapping and demapping for 2(sup 2n+1)-QAM.

  19. Reactive molecular dynamics of network polymers: Generation, characterization and mechanical properties

    NASA Astrophysics Data System (ADS)

    Shankar, Chandrashekar

    The goal of this research was to gain a fundamental understanding of the properties of networks created by the ring opening metathesis polymerization (ROMP) of dicyclopentadiene (DCPD) used in self-healing materials. To this end we used molecular simulation methods to generate realistic structures of DCPD networks, characterize their structures, and determine their mechanical properties. Density functional theory (DFT) calculations, complemented by structural information derived from molecular dynamics simulations were used to reconstruct experimental Raman spectra and differential scanning calorimetry (DSC) data. We performed coarse-grained simulations comparing networks generated via the ROMP reaction process and compared them to those generated via a RANDOM process, which led to the fundamental realization that the polymer topology has a unique influence on the network properties. We carried out fully atomistic simulations of DCPD using a novel algorithm for recreating ROMP reactions of DCPD molecules. Mechanical properties derived from these atomistic networks are in excellent agreement with those obtained from coarse-grained simulations in which interactions between nodes are subject to angular constraints. This comparison provides self-consistent validation of our simulation results and helps to identify the level of detail necessary for the coarse-grained interaction model. Simulations suggest networks can classified into three stages: fluid-like, rubber-like or glass-like delineated by two thresholds in degree of reaction alpha: The onset of finite magnitudes for the Young's modulus, alphaY, and the departure of the Poisson ration from 0.5, alphaP. In each stage the polymer exhibits a different predominant mechanical response to deformation. At low alpha < alphaY it flows. At alpha Y < alpha < alphaP the response is entropic with no change in internal energy. At alpha > alphaP the response is enthalpic change in internal energy. We developed graph theory-based network characterizations to correlate between network topology and the simulated mechanical properties. (1) Eigenvector centrality (2) Graph fractal dimension, (3) Fiedler partitioning, and (4) Cross-link fraction (Q3+Q4). Of these quantities, the Fiedler partition is the best characteristic for the prediction of Young's Modulus. The new computational tools developed in this research are of great fundamental and practical interest.

  20. Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia.

    PubMed

    Law, Philip J; Berndt, Sonja I; Speedy, Helen E; Camp, Nicola J; Sava, Georgina P; Skibola, Christine F; Holroyd, Amy; Joseph, Vijai; Sunter, Nicola J; Nieters, Alexandra; Bea, Silvia; Monnereau, Alain; Martin-Garcia, David; Goldin, Lynn R; Clot, Guillem; Teras, Lauren R; Quintela, Inés; Birmann, Brenda M; Jayne, Sandrine; Cozen, Wendy; Majid, Aneela; Smedby, Karin E; Lan, Qing; Dearden, Claire; Brooks-Wilson, Angela R; Hall, Andrew G; Purdue, Mark P; Mainou-Fowler, Tryfonia; Vajdic, Claire M; Jackson, Graham H; Cocco, Pierluigi; Marr, Helen; Zhang, Yawei; Zheng, Tongzhang; Giles, Graham G; Lawrence, Charles; Call, Timothy G; Liebow, Mark; Melbye, Mads; Glimelius, Bengt; Mansouri, Larry; Glenn, Martha; Curtin, Karen; Diver, W Ryan; Link, Brian K; Conde, Lucia; Bracci, Paige M; Holly, Elizabeth A; Jackson, Rebecca D; Tinker, Lesley F; Benavente, Yolanda; Boffetta, Paolo; Brennan, Paul; Maynadie, Marc; McKay, James; Albanes, Demetrius; Weinstein, Stephanie; Wang, Zhaoming; Caporaso, Neil E; Morton, Lindsay M; Severson, Richard K; Riboli, Elio; Vineis, Paolo; Vermeulen, Roel C H; Southey, Melissa C; Milne, Roger L; Clavel, Jacqueline; Topka, Sabine; Spinelli, John J; Kraft, Peter; Ennas, Maria Grazia; Summerfield, Geoffrey; Ferri, Giovanni M; Harris, Robert J; Miligi, Lucia; Pettitt, Andrew R; North, Kari E; Allsup, David J; Fraumeni, Joseph F; Bailey, James R; Offit, Kenneth; Pratt, Guy; Hjalgrim, Henrik; Pepper, Chris; Chanock, Stephen J; Fegan, Chris; Rosenquist, Richard; de Sanjose, Silvia; Carracedo, Angel; Dyer, Martin J S; Catovsky, Daniel; Campo, Elias; Cerhan, James R; Allan, James M; Rothman, Nathanial; Houlston, Richard; Slager, Susan

    2017-02-06

    Several chronic lymphocytic leukaemia (CLL) susceptibility loci have been reported; however, much of the heritable risk remains unidentified. Here we perform a meta-analysis of six genome-wide association studies, imputed using a merged reference panel of 1,000 Genomes and UK10K data, totalling 6,200 cases and 17,598 controls after replication. We identify nine risk loci at 1p36.11 (rs34676223, P=5.04 × 10 -13 ), 1q42.13 (rs41271473, P=1.06 × 10 -10 ), 4q24 (rs71597109, P=1.37 × 10 -10 ), 4q35.1 (rs57214277, P=3.69 × 10 -8 ), 6p21.31 (rs3800461, P=1.97 × 10 -8 ), 11q23.2 (rs61904987, P=2.64 × 10 -11 ), 18q21.1 (rs1036935, P=3.27 × 10 -8 ), 19p13.3 (rs7254272, P=4.67 × 10 -8 ) and 22q13.33 (rs140522, P=2.70 × 10 -9 ). These new and established risk loci map to areas of active chromatin and show an over-representation of transcription factor binding for the key determinants of B-cell development and immune response.

  1. A comparative study evaluating the efficacy of IS_MAP04 with IS900 and IS_MAP02 as a new diagnostic target for the detection of Mycobacterium avium subspecies paratuberculosis from bovine faeces.

    PubMed

    de Kruijf, Marcel; Govender, Rodney; Yearsley, Dermot; Coffey, Aidan; O'Mahony, Jim

    2017-05-01

    The aim of this study was to investigate the efficacy of IS_MAP04 as a potential new diagnostic quantitative PCR (qPCR) target for the detection of Mycobacterium avium subspecies paratuberculosis from bovine faeces. IS_MAP04 primers were designed and tested negative against non-MAP strains. The detection limit of IS_MAP04 qPCR was evaluated on different MAP K-10 DNA concentrations and on faecal samples spiked with different MAP K-10 cell dilutions. A collection of 106 faecal samples was analysed and the efficacy of IS_MAP04 was statistically compared with IS900 and IS_MAP02. The detection limits observed for IS_MAP04 and IS900 on MAP DNA was 34 fg and 3.4 fg respectively. The detection limit of MAP from inoculated faecal samples was 10 2 CFU/g for both IS_MAP04 and IS900 targets and a detection limit of 10 2 CFU/g was also achieved with a TaqMan qPCR targeting IS_MAP04. The efficacy of IS_MAP04 to detect positive MAP faecal samples was 83.0% compared to 85.8% and 83.9% for IS900 and IS_MAP02 respectively. Strong kappa agreements were observed between IS_MAP04 and IS900 (κ=0.892) and between IS_MAP04 and IS_MAP02 (κ=0.897). As a new molecular target, IS_MAP04 showed that the detection limit was comparable to IS900 to detect MAP from inoculated faecal material. The MAP detection efficacy of IS_MAP04 from naturally infected faecal samples proved to be relatively comparable to IS_MAP02, but yielded efficacy results slightly less than IS900. Moreover, IS_MAP04 could be of significant value when used in duplex or multiplex qPCR assays. Copyright © 2017 Elsevier B.V. All rights reserved.

  2. 26 CFR 54.4980B-4 - Qualifying events.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 17 2012-04-01 2012-04-01 false Qualifying events. 54.4980B-4 Section 54.4980B... EXCISE TAXES (CONTINUED) PENSION EXCISE TAXES § 54.4980B-4 Qualifying events. The determination of what constitutes a qualifying event is addressed in the following questions and answers: Q-1: What is a qualifying...

  3. 26 CFR 54.4980B-4 - Qualifying events.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 17 2013-04-01 2013-04-01 false Qualifying events. 54.4980B-4 Section 54.4980B... EXCISE TAXES (CONTINUED) PENSION EXCISE TAXES § 54.4980B-4 Qualifying events. The determination of what constitutes a qualifying event is addressed in the following questions and answers: Q-1: What is a qualifying...

  4. 26 CFR 54.4980B-4 - Qualifying events.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 17 2011-04-01 2011-04-01 false Qualifying events. 54.4980B-4 Section 54.4980B... EXCISE TAXES (CONTINUED) PENSION EXCISE TAXES § 54.4980B-4 Qualifying events. The determination of what constitutes a qualifying event is addressed in the following questions and answers: Q-1: What is a qualifying...

  5. 26 CFR 54.4980B-4 - Qualifying events.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 17 2014-04-01 2014-04-01 false Qualifying events. 54.4980B-4 Section 54.4980B... EXCISE TAXES (CONTINUED) PENSION EXCISE TAXES § 54.4980B-4 Qualifying events. The determination of what constitutes a qualifying event is addressed in the following questions and answers: Q-1: What is a qualifying...

  6. The Role of mGluR Copy Number Variation in Genetic and Environmental Forms of Syndromic Autism Spectrum Disorder.

    PubMed

    Wenger, Tara L; Kao, Charlly; McDonald-McGinn, Donna M; Zackai, Elaine H; Bailey, Alice; Schultz, Robert T; Morrow, Bernice E; Emanuel, Beverly S; Hakonarson, Hakon

    2016-01-19

    While abnormal signaling mediated through metabotropic glutamate receptor 5 (mGluR5) is involved in the pathophysiology of Autism Spectrum Disorder (ASD), Fragile X Syndrome and Tuberous Sclerosis, the role of other mGluRs and their associated signaling network genes in syndromic ASD is unknown. This study sought to determine whether mGluR Copy Number Variants (CNV's) were overrepresented in children with syndromic ASD and if mGluR "second hit" confers additional risk for ASD in 22q11.2 Deletion Syndrome (22q11DS). To determine whether mGluR network CNV'S are enriched in syndromic ASD, we examined microarrays from children with ASD (n = 539). Patient categorization (syndromic vs nonsyndromic) was done via blinded medical chart review in mGluR positive and randomly selected mGluR negative cases. 11.5% of ASD had mGluR CNV's vs. 3.2% in controls (p < 0.001). Syndromic ASD was more prevalent in children with mGluR CNVs (74% vs 16%, p < 0.001). A comparison cohort with 22q11DS (n = 25 with ASD, n = 50 without ASD), all haploinsufficient for mGluR network gene RANBP1, were evaluated for "second mGluR hits". 20% with 22q11.2DS + ASD had "second hits" in mGluR network genes vs 2% in 22q11.2DS-ASD (p < 0.014). We propose that altered RANBP1 expression may provide a mechanistic link for several seemingly unrelated genetic and environmental forms of ASD.

  7. The Role of mGluR Copy Number Variation in Genetic and Environmental Forms of Syndromic Autism Spectrum Disorder

    PubMed Central

    Wenger, Tara L.; Kao, Charlly; McDonald-McGinn, Donna M.; Zackai, Elaine H.; Bailey, Alice; Schultz, Robert T.; Morrow, Bernice E.; Emanuel, Beverly S.; Hakonarson, Hakon

    2016-01-01

    While abnormal signaling mediated through metabotropic glutamate receptor 5 (mGluR5) is involved in the pathophysiology of Autism Spectrum Disorder (ASD), Fragile X Syndrome and Tuberous Sclerosis, the role of other mGluRs and their associated signaling network genes in syndromic ASD is unknown. This study sought to determine whether mGluR Copy Number Variants (CNV’s) were overrepresented in children with syndromic ASD and if mGluR “second hit” confers additional risk for ASD in 22q11.2 Deletion Syndrome (22q11DS). To determine whether mGluR network CNV’S are enriched in syndromic ASD, we examined microarrays from children with ASD (n = 539). Patient categorization (syndromic vs nonsyndromic) was done via blinded medical chart review in mGluR positive and randomly selected mGluR negative cases. 11.5% of ASD had mGluR CNV’s vs. 3.2% in controls (p < 0.001). Syndromic ASD was more prevalent in children with mGluR CNVs (74% vs 16%, p < 0.001). A comparison cohort with 22q11DS (n = 25 with ASD, n = 50 without ASD), all haploinsufficient for mGluR network gene RANBP1, were evaluated for “second mGluR hits”. 20% with 22q11.2DS + ASD had “second hits” in mGluR network genes vs 2% in 22q11.2DS-ASD (p < 0.014). We propose that altered RANBP1 expression may provide a mechanistic link for several seemingly unrelated genetic and environmental forms of ASD. PMID:26781481

  8. Electrical Resistivity of Chromium, Cobalt, Iron, and Nickel.

    DTIC Science & Technology

    1982-06-01

    V * E ; u to 1 0 .’ 0 1 In m .10 U~0 40..- 4 4 a U -- W r 00 r1 C0 1a 1 0 0 . 441 1 -41 W 00 0 .40 0 0 ’cc 0 41 1.4 08 0𔃻 all . 0 41 051 " 0 - 4...0- .C w T . f Q4 0 if n ~ w bc 0. 41. m4~i 04 0’ if 00 Ŕ 0 t ’ 0 e ToC c. . C:-04 . 4 4 f .- . i 0.00 0’ *if’-𔃺. 0 0 a, C.) ) 0 , u 0 cx - v CA M...8217 az a a c -P 0 4.4 4.. 1 4..4. 4-* U on 40. r4 r.C . 3.4.1. OD * 0 OUD 0 4 27 0 0 E .. 0. j en 1. 00 0% w ’A 0. 00 v .1 - I 1 10. 0 Q en CL 9: 41 a

  9. Increased pediatric sub-specialization is associated with decreased surgical complication rates for inpatient pediatric urology procedures

    PubMed Central

    Tejwani, R.; Wang, H-H. S.; Young, B. J.; Greene, N. H.; Wolf, S.; Wiener, J. S.; Routh, J. C.

    2016-01-01

    Summary Introduction Increased case volumes and training are associated with better surgical outcomes. However, the impact of pediatric urology sub-specialization on perioperative complication rates is unknown. Objectives To determine the presence and magnitude of difference in rates of common postoperative complications for elective pediatric urology procedures between specialization levels of urologic surgeons. The Nationwide Inpatient Sample (NIS), a nationally representative administrative database, was used. Study Design The NIS (1998–2009) was retrospectively reviewed for pediatric (≤18 years) admissions, using ICD-9-CM codes to identify urologic surgeries and National Surgical Quality Improvement Program (NSQIP) inpatient postoperative complications. Degree of pediatric sub-specialization was calculated using a Pediatric Proportion Index (PPI), defined as the ratio of children to total patients operated on by each provider. The providers were grouped into PPI quartiles: Q1, 0–25% specialization; Q2, 25–50%; Q3, 50–75%; Q4, 75–100%. Weighted multivariate analysis was performed to test for associations between PPI and surgical complications. Results A total of 71,479 weighted inpatient admissions were identified. Patient age decreased with increasing specialization: Q1, 7.9 vs Q2, 4.8 vs Q3, 4.8 vs Q4, 4.6 years, P<0.01). Specialization was not associated with race (P>0.20), gender (P>0.50), or comorbidity scores (P=0.10). Mortality (1.5% vs 0.2% vs 0.3% vs 0.4%, P<0.01) and complication rates (15.5% vs 11.7% vs 9.6% vs 10.9%, P<0.0001) both decreased with increasing specialization. Patients treated by more highly specialized surgeons incurred slightly higher costs (Q2, +4%; Q3, +1%; Q4 + 2%) but experienced shorter length of hospital stay (Q2, –5%; Q3, –10%; Q4, –3%) compared with the least specialized providers. A greater proportion of patients treated by Q1 and Q3 specialized urologists had CCS ≥2 than those seen by Q2 or Q4 urologists (12.5% and 12.2%, respectively vs 8.4% and 10.9%, respectively, P=0.04). Adjusting for confounding effects, increased pediatric specialization was associated with decreased postoperative complications: Q2 OR 0.78, CI 0.58–1.05; Q3 OR 0.60, CI 0.44–0.84; Q4 OR 0.70, CI 0.58–0.84; P<0.01. Discussion Providers with proportionally higher volumes of pediatric patients achieved better postoperative outcomes than their less sub-specialized counterparts. This may have arisen from increased exposure to pediatric anatomy and physiology, and greater familiarity with pediatric techniques. Limitation The NIS admission-based retrospective design did not enable assessment of long-term outcomes, repeated admissions, or to track a particular patient across time. The study was similarly limited in evaluating the effect of pre-surgical referral patterns on patient distributions. Conclusions Increased pediatric sub-specialization among urologists was associated with a decreased risk of mortality and surgical complications in children undergoing inpatient urologic procedures. PMID:27363329

  10. Increased pediatric sub-specialization is associated with decreased surgical complication rates for inpatient pediatric urology procedures.

    PubMed

    Tejwani, R; Wang, H-H S; Young, B J; Greene, N H; Wolf, S; Wiener, J S; Routh, J C

    2016-12-01

    Increased case volumes and training are associated with better surgical outcomes. However, the impact of pediatric urology sub-specialization on perioperative complication rates is unknown. To determine the presence and magnitude of difference in rates of common postoperative complications for elective pediatric urology procedures between specialization levels of urologic surgeons. The Nationwide Inpatient Sample (NIS), a nationally representative administrative database, was used. The NIS (1998-2009) was retrospectively reviewed for pediatric (≤18 years) admissions, using ICD-9-CM codes to identify urologic surgeries and National Surgical Quality Improvement Program (NSQIP) inpatient postoperative complications. Degree of pediatric sub-specialization was calculated using a Pediatric Proportion Index (PPI), defined as the ratio of children to total patients operated on by each provider. The providers were grouped into PPI quartiles: Q1, 0-25% specialization; Q2, 25-50%; Q3, 50-75%; Q4, 75-100%. Weighted multivariate analysis was performed to test for associations between PPI and surgical complications. A total of 71,479 weighted inpatient admissions were identified. Patient age decreased with increasing specialization: Q1, 7.9 vs Q2, 4.8 vs Q3, 4.8 vs Q4, 4.6 years, P < 0.01). Specialization was not associated with race (P > 0.20), gender (P > 0.50), or comorbidity scores (P = 0.10). Mortality (1.5% vs 0.2% vs 0.3% vs 0.4%, P < 0.01) and complication rates (15.5% vs 11.7% vs 9.6% vs 10.9%, P < 0.0001) both decreased with increasing specialization. Patients treated by more highly specialized surgeons incurred slightly higher costs (Q2, +4%; Q3, +1%; Q4 + 2%) but experienced shorter length of hospital stay (Q2, -5%; Q3, -10%; Q4, -3%) compared with the least specialized providers. A greater proportion of patients treated by Q1 and Q3 specialized urologists had CCS ≥2 than those seen by Q2 or Q4 urologists (12.5% and 12.2%, respectively vs 8.4% and 10.9%, respectively, P = 0.04). Adjusting for confounding effects, increased pediatric specialization was associated with decreased postoperative complications: Q2 OR 0.78, CI 0.58-1.05; Q3 OR 0.60, CI 0.44-0.84; Q4 OR 0.70, CI 0.58-0.84; P < 0.01. Providers with proportionally higher volumes of pediatric patients achieved better postoperative outcomes than their less sub-specialized counterparts. This may have arisen from increased exposure to pediatric anatomy and physiology, and greater familiarity with pediatric techniques. The NIS admission-based retrospective design did not enable assessment of long-term outcomes, repeated admissions, or to track a particular patient across time. The study was similarly limited in evaluating the effect of pre-surgical referral patterns on patient distributions. Increased pediatric sub-specialization among urologists was associated with a decreased risk of mortality and surgical complications in children undergoing inpatient urologic procedures. Copyright © 2016 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.

  11. The Effect of Single and Double Acetylation of Lysine Residues on Structural and Dynamical Features of Human Splicing Factor TDP-43 - A Statistical Ensemble Analysis.

    PubMed

    Makhouri, Farahnaz Rezaei; Ghasemi, Jahan B

    2018-06-04

    The acetylated inclusions containing TDP-43 are found in the spinal cord of amyotrophic lateral sclerosis (ALS) patients, suggesting that aberrant TDP-43 acetylation and resulting disruption of RNA binding are linked to onset and progression of TDP-43 proteinopathy. Here, the consequences of TDP-43 acetylation at Lys145 within the RRM1 domain and Lys192 within the RRM2 domain were studied using experimentally verifiable molecular models, in which lysine residues (K) were substituted with glutamine (Q) as an acetylation mimic (K→Q) and with arginine (R) as a non-mimic (K→R) mutant. We used a series of computer simulations to characterize the impact of lysine acetylation on TDP-43 function and TDP-43 association with target RNA. Using snapshots collected from the MD simulation trajectories, the cross-correlation and principal component analyses (PCA) were applied to shed light on the dynamic discrepancy among the ten studied systems and to discern TDP-43 subdomains that exhibit conformational plasticity in response to acetylation mimic and non-mimic mutations. Moreover, we also investigated the global network parameter, betweenness, to model communication pathways and identify a network of critical mediating nodes involved in long-range signaling. These nodes describe the functionally significant TDP-43 residues involved in TDP-43 regulation. The identification of the critical nodes and optimal path mediating the dynamical network communication could offer new strategies to manipulate TDP-43 function. Disrupting a specific network communication could represent a rational approach to the design of drugs with improved potency and selectivity. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  12. Genome-Wide Analysis of Long Noncoding RNA (lncRNA) Expression in Hepatoblastoma Tissues

    PubMed Central

    Xue, Ping; Cui, Ximao; Li, Kai; Zheng, Shan; He, Xianghuo; Dong, Kuiran

    2014-01-01

    Long noncoding RNAs (lncRNAs) have crucial roles in cancer biology. We performed a genome-wide analysis of lncRNA expression in hepatoblastoma tissues to identify novel targets for further study of hepatoblastoma. Hepatoblastoma and normal liver tissue samples were obtained from hepatoblastoma patients. The genome-wide analysis of lncRNA expression in these tissues was performed using a 4×180 K lncRNA microarray and Sureprint G3 Human lncRNA Chips. Quantitative RT-PCR (qRT-PCR) was performed to confirm these results. The differential expressions of lncRNAs and mRNAs were identified through fold-change filtering. Gene Ontology (GO) and pathway analyses were performed using the standard enrichment computation method. Associations between lncRNAs and adjacent protein-coding genes were determined through complex transcriptional loci analysis. We found that 2736 lncRNAs were differentially expressed in hepatoblastoma tissues. Among these, 1757 lncRNAs were upregulated more than two-fold relative to normal tissues and 979 lncRNAs were downregulated. Moreover, in hepatoblastoma there were 420 matched lncRNA-mRNA pairs for 120 differentially expressed lncRNAs, and 167 differentially expressed mRNAs. The co-expression network analysis predicted 252 network nodes and 420 connections between 120 lncRNAs and 132 coding genes. Within this co-expression network, 369 pairs were positive, and 51 pairs were negative. Lastly, qRT-PCR data verified six upregulated and downregulated lncRNAs in hepatoblastoma, plus endothelial cell-specific molecule 1 (ESM1) mRNA. Our results demonstrated that expression of these aberrant lncRNAs could respond to hepatoblastoma development. Further study of these lncRNAs could provide useful insight into hepatoblastoma biology. PMID:24465615

  13. Predicting HIV-1 broadly neutralizing antibody epitope networks using neutralization titers and a novel computational method

    PubMed Central

    2014-01-01

    Background Recent efforts in HIV-1 vaccine design have focused on immunogens that evoke potent neutralizing antibody responses to a broad spectrum of viruses circulating worldwide. However, the development of effective vaccines will depend on the identification and characterization of the neutralizing antibodies and their epitopes. We developed bioinformatics methods to predict epitope networks and antigenic determinants using structural information, as well as corresponding genotypes and phenotypes generated by a highly sensitive and reproducible neutralization assay. 282 clonal envelope sequences from a multiclade panel of HIV-1 viruses were tested in viral neutralization assays with an array of broadly neutralizing monoclonal antibodies (mAbs: b12, PG9,16, PGT121 - 128, PGT130 - 131, PGT135 - 137, PGT141 - 145, and PGV04). We correlated IC50 titers with the envelope sequences, and used this information to predict antibody epitope networks. Structural patches were defined as amino acid groups based on solvent-accessibility, radius, atomic depth, and interaction networks within 3D envelope models. We applied a boosted algorithm consisting of multiple machine-learning and statistical models to evaluate these patches as possible antibody epitope regions, evidenced by strong correlations with the neutralization response for each antibody. Results We identified patch clusters with significant correlation to IC50 titers as sites that impact neutralization sensitivity and therefore are potentially part of the antibody binding sites. Predicted epitope networks were mostly located within the variable loops of the envelope glycoprotein (gp120), particularly in V1/V2. Site-directed mutagenesis experiments involving residues identified as epitope networks across multiple mAbs confirmed association of these residues with loss or gain of neutralization sensitivity. Conclusions Computational methods were implemented to rapidly survey protein structures and predict epitope networks associated with response to individual monoclonal antibodies, which resulted in the identification and deeper understanding of immunological hotspots targeted by broadly neutralizing HIV-1 antibodies. PMID:24646213

  14. All Prime Contract Awards by State or Country, Place, and Contractor, FY 84. Part 8 (Adrian, Michigan - Tilton-Northfield, New Hampshire).

    DTIC Science & Technology

    1984-01-01

    00 O 0 0000000000 00 0 N 4Nj E< 490 w1 W0 0.4w ww ww 0. Iq CD () WWW W 0< 04 ɘ Do i 0 C04 04 00 -0 :)0000000000 0 00 w 0 0 WOi 0 D 0 𔃺 0 0 w Li 4...NNNNNNNNN D< (0 <<򒟀 0- OO O OO O O ON O .- -- 0 00000000 0" C),q xt www D 0 0 (. 0 L - .0 -, 00 o 0 0 0 0 0 0 0 i o o o 0 0 000 0 E0 LU LWL LWI -L z z z z...z0 C Z) CD - . .N 0 0 0 L- < CD J - \\QO .7 LCD000000 0000- WWW (DIDW0W InNNNNN0D ) cJN 40 Iii 4.N0 ) -f .q 4 40 000N -00(0 D- I t) WV0000N 107 0 ) N

  15. Projections of Demand for Waterborne Transportation, Ohio River Basin, 1980, 1990, 2000, 2020, 2040. Volume 9. Group VII. Ores and Minerals.

    DTIC Science & Technology

    1980-12-01

    U l 0 0 ) C 4140 c4 34jE 04 0)t 03.- In lo No ID 0ID 6)ID M). U 0 ( in cc m m m c m mm m a a) la.0u) 0r- 02d)20 C ’N C ~ 3 C -27- c -o 0 It14’ 0 14 tn...N 1.D/ c4 0)00E w.~ 0 V-- -"- -- V04 M1)4VdW -4I -..- 1. 0001M.-40 00 4D4J.’ ::l c:; Q o u00 0 0.0 a 0~~ ~ m𔃺 w , 0-0m.-Q)uH 1.4 0 : . 0 4140 .0 ZZl...Statistical Report. 1969-78 eds. Washington, D.C.: AISI , 1970-79. American Metal Market. Metal Statistics. 1970 -d. New York: Fairchild, 1976. "Facts and

  16. Neighbourhood walkability, daily steps and utilitarian walking in Canadian adults.

    PubMed

    Hajna, Samantha; Ross, Nancy A; Joseph, Lawrence; Harper, Sam; Dasgupta, Kaberi

    2015-11-24

    To estimate the associations of neighbourhood walkability (based on Geographic Information System (GIS)-derived measures of street connectivity, land use mix, and population density and the Walk Score) with self-reported utilitarian walking and accelerometer-assessed daily steps in Canadian adults. A cross-sectional analysis of data collected as part of the Canadian Health Measures Survey (2007-2009). Home neighbourhoods (500 m polygonal street network buffers around the centroid of the participant's postal code) located in Atlantic Canada, Québec, Ontario, the Prairies and British Columbia. 5605 individuals participated in the survey. 3727 adults (≥18 years) completed a computer-assisted interview and attended a mobile clinic assessment. Analyses were based on those who had complete exposure, outcome and covariate data (n=2949). GIS-derived walkability (based on land use mix, street connectivity and population density); Walk Score. Self-reported utilitarian walking; accelerometer-assessed daily steps. No important relationship was observed between neighbourhood walkability and daily steps. Participants who reported more utilitarian walking, however, accumulated more steps (<1 h/week: 6613 steps/day, 95% CI 6251 to 6975; 1 to 5 h/week: 6768 steps/day, 95% CI 6420 to 7117; ≥6 h/week: 7391 steps/day, 95% CI 6972 to 7811). There was a positive graded association between walkability and odds of walking ≥1 h/week for utilitarian purposes (eg, Q4 vs Q1 of GIS-derived walkability: OR=1.66, 95% CI 1.31 to 2.11; Q3 vs Q1: OR=1.41, 95% CI 1.14 to 1.76; Q2 vs Q1: OR=1.13, 95% CI 0.91 to 1.39) independent of age, sex, body mass index, married/common law status, annual household income, having children in the household, immigrant status, mood disorder, perceived health, ever smoker and season. Contrary to expectations, living in more walkable Canadian neighbourhoods was not associated with more total walking. Utilitarian walking and daily steps were, however, correlated and walkability demonstrated a positive graded relationship with utilitarian walking. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  17. Non-invasive brain stimulation for fine motor improvement after stroke: a meta-analysis.

    PubMed

    O'Brien, A T; Bertolucci, F; Torrealba-Acosta, G; Huerta, R; Fregni, F; Thibaut, A

    2018-05-09

    The aim of this study was to determine whether non-invasive brain stimulation (NIBS) techniques improve fine motor performance in stroke. We searched PubMed, EMBASE, Web of Science, SciELO and OpenGrey for randomized clinical trials on NIBS for fine motor performance in stroke patients and healthy participants. We computed Hedges' g for active and sham groups, pooled data as random-effects models and performed sensitivity analysis on chronicity, montage, frequency of stimulation and risk of bias. Twenty-nine studies (351 patients and 152 healthy subjects) were reviewed. Effect sizes in stroke populations for transcranial direct current stimulation and repeated transcranial magnetic stimulation were 0.31 [95% confidence interval (CI), 0.08-0.55; P = 0.010; Tau 2 , 0.09; I 2 , 34%; Q, 18.23; P = 0.110] and 0.46 (95% CI, 0.00-0.92; P = 0.05; Tau 2 , 0.38; I 2 , 67%; Q, 30.45; P = 0.007). The effect size of non-dominant healthy hemisphere transcranial direct current stimulation on non-dominant hand function was 1.25 (95% CI, 0.09-2.41; P = 0.04; Tau 2 , 1.26; I 2 , 93%; Q, 40.27; P < 0.001). Our results show that NIBS is associated with gains in fine motor performance in chronic stroke patients and healthy subjects. This supports the effects of NIBS on motor learning and encourages investigation to optimize their effects in clinical and research settings. © 2018 EAN.

  18. Global Maps of Temporal Streamflow Characteristics Based on Observations from Many Small Catchments

    NASA Astrophysics Data System (ADS)

    Beck, H.; van Dijk, A.; de Roo, A.

    2014-12-01

    Streamflow (Q) estimation in ungauged catchments is one of the greatest challenges facing hydrologists. We used observed Q from approximately 7500 small catchments (<10,000 km2) around the globe to train neural network ensembles to estimate temporal Q distribution characteristics from climate and physiographic characteristics of the catchments. In total 17 Q characteristics were selected, including mean annual Q, baseflow index, and a number of flow percentiles. Training coefficients of determination for the estimation of the Q characteristics ranged from 0.56 for the baseflow recession constant to 0.93 for the Q timing. Overall, climate indices dominated among the predictors. Predictors related to soils and geology were the least important, perhaps due to data quality. The trained neural network ensembles were subsequently applied spatially over the ice-free land surface including ungauged regions, resulting in global maps of the Q characteristics (0.125° spatial resolution). These maps possess several unique features: 1) they represent purely observation-driven estimates; 2) are based on an unprecedentedly large set of catchments; and 3) have associated uncertainty estimates. The maps can be used for various hydrological applications, including the diagnosis of macro-scale hydrological models. To demonstrate this, the produced maps were compared to equivalent maps derived from the simulated daily Q of five macro-scale hydrological models, highlighting various opportunities for improvement in model Q behavior. The produced dataset is available for download.

  19. 26 CFR 1.669(a)-3 - Tax computed by the exact throwback method.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 8 2010-04-01 2010-04-01 false Tax computed by the exact throwback method. 1... Taxable Years Beginning Before January 1, 1969 § 1.669(a)-3 Tax computed by the exact throwback method. (a... compute the tax, on amounts deemed distributed under section 666, by the exact throwback method provided...

  20. Department of the Navy Justification of Estimates for Fiscal Year 1988/1989 Submitted to Congress. Operation & Maintenance, Marine Corps.

    DTIC Science & Technology

    1987-01-01

    N $0 4 >U4. .v i 104 00 0 00 w 4) 0 :3 N r.’U -r4 0 0400 9~~ 0 (a~ ~!k= 4- w A = :3 ki td 0 l i C4In 0 m 0-4 0 NQ m m Qo o mL q~ rr-4m Q v N . 4... 4bd IV 4 a 0 k 6- u* ’ 44 0% 4 h hi Ř 0 -4 Ř 0 V’ wi *4 6 600. J a 0 $4 41 4 Q P4 6k Ca at%~ 640 4 hi � ki -4 4 $i F’ 6 4 .0 41-4 M, 0 % 4 +i c...34444 V) 9; H 𔃺 4.) W r1) 0 go 02 V4 02 *4 4)0 0 g 𔃺 𔃺 -’-4 H 0 0 - > 41 0~ 4) 0d 0 0 0 $4 (A0 .02 td 0 r * r q la0 . 10 rd 4H 04 4 .) v . 4. u.’ 50

  1. [Association between hair cortisol concentration and overweight and obesity in 6-9 years old childhood].

    PubMed

    Hu, J J; Duan, X N; Fang, J; Xu, N; Wan, Y H; Su, P Y; Tao, F B; Sun, Y

    2017-12-06

    Objective: To determine the possible relations between hair cortisol concentration (HCC) as a biomarker of chronic stress and childhood overweight and obesity. Methods: Children from grade 1 to 3 from 2 primary schools in Bengbu were invited to participate in the study; and those who suffer from mental disorders, endocrine diseases and those who took hormone drugs were excluded. Parental questionnaire was implemented to collect information on physical activity, screen time, sleep duration, sugar-beverage consumption, as well as socio-economic status. Height and weight were examined. Eligible hair samples from 1 263 children (598 boys and 665 girls) were obtained, and the cortisol content was determined. Multivariate logistic regression model analysis was recruited to examine the association between HCC quartiles and overweight and obesity among boys and girls, respectively. Results: HCC in P (50) ( P (25)- P (75)) among girls and boys was separately 11.86 (10.57-13.15) and 11.71 (10.54-13.09) µg/kg ( Z=- 0.886, P= 0.376); HCC in P (50) ( P (25)- P (75)) among non-overweight, overweight and obesity boys was separately 11.62 (10.45-12.82), 12.24 (10.88-13.55) and 12.30 (10.99-13.53) µg/kg (χ(2)=8.24, P= 0.016); HCC in P (50) ( P (25)- P (75)) among non-overweight, overweight and obesity girls was separately 11.35 (10.06-12.62), 12.07 (11.04-13.21) and 12.59 (11.12-13.63) µg/kg (χ(2)=36.16, P< 0.001). After age, physical activity, screen time, sleep duration, sugared beverages and socio-economic status adjusted, compared with HCC in Q 1 level, girls whose HCC in Q 2, Q 3 Q 4 level had higher rates in overweight, with OR (95 %CI ) at 1.10 (1.04-3.32), 2.59 (1.51-4.45) and 3.16 (1.79-5.57), respectively. Girls with HCC in Q 3 and Q 4 level had higher rates in obesity, with OR (95 %CI ) at 2.22 (1.16-4.26) and 5.62 (3.04-10.41). Among boys, highest quartiles in HCC was risk factor for overweight, OR (95 %CI ) was 2.14 (1.18-3.90). Conclusion: Hair cortisol had a significant relation with overweight and obesity in 6-9 years old childhood especially among girls.

  2. Mapping the q-voter model: From a single chain to complex networks

    NASA Astrophysics Data System (ADS)

    Jȩdrzejewski, Arkadiusz; Sznajd-Weron, Katarzyna; Szwabiński, Janusz

    2016-03-01

    We propose and compare six different ways of mapping the modified q-voter model to complex networks. Considering square lattices, Barabási-Albert, Watts-Strogatz and real Twitter networks, we ask the question if always a particular choice of the group of influence of a fixed size q leads to different behavior at the macroscopic level. Using Monte Carlo simulations we show that the answer depends on the relative average path length of the network and for real-life topologies the differences between the considered mappings may be negligible.

  3. A new expression for computing the bottomside thickness parameter and comparisons with the NeQuick and IRI-2012 models during declining phase of solar cycle 23 at equatorial latitude station, Chumphon, Thailand

    NASA Astrophysics Data System (ADS)

    Jamjareegulgarn, Punyawi; Supnithi, Pornchai; Watthanasangmechai, Kornyanat; Yokoyama, Tatsuhiro; Tsugawa, Takuya; Ishii, Mamoru

    2017-07-01

    This paper proposes a new expression for computing the bottomside thickness parameter at equatorial latitude station, Chumphon (10.72°N, 99.37°E), Thailand. Its diurnal variations from 2004 to 2006 at this location are then studied. The proposed expression is derived based on two experimental data sources: FMCW ionosonde and dual-frequency GPS system, and some expressions of the NeQuick 2 model. Hence, after both the bottomside thickness parameter computed by the proposed equation, B2bot_Pro, and the bottomside shape parameter (namely, B1_Pro in this work) are computed, the bottomside electron density and the height where the bottomside electron density drops down to be 24% of the NmF2 (namely, h0.24) can be computed and shown in this work using the analytical functions of the IRI model. Moreover, the diurnal variations of the B2bot_Pro are compared with those computed from the NeQuick model, B2bot_NeQ, and the predicted B0 of the IRI-2012 model with ABT-2009 and Bil-2000 options (namely, ;B0_ABT; and ;B0_Bil;, respectively). The averaged, minimum, and maximum values of percentage deviations among these bottomside thickness parameters are also computed and shown in this work. Our results show that the diurnal variations of B2bot_Pro at Chumphon station have the following patterns: they start to increase during nighttime to the first peaks during pre-sunrise hours, and then decrease abruptly to their minimum values during sunrise hours. Afterward, they increase again to reach the second peaks around local noontime and fall gradually to their starting times during 20-04 LT. The diurnal variations of B2bot_Pro follow generally the same trends as those of the B2bot_NeQ and the B0_ABT, except pre-sunrise hours. The pre-sunrise peaks and sunrise collapses in both the B2bot_NeQ and the B0_ABT can be found occasionally. On the other hand, the diurnal variations in B2bot_Pro differ from those in B0_Bil due to the flattened variation in B0_Bil and the pre-sunrise peaks as well as sunrise collapses in B0_Bil disappear. The pre-sunrise peaks of the B2bot_Pro at the Chumphon station are higher than those of the B2bot_NeQ, the B0_ABT, and the observed B0 at other regions. Furthermore, the percentage deviations between the B2bot_Pro and the B0_ABT (PD_B2B0ABT) are mostly lower than 30% for all seasons of the studied years, opposite to the other percentage deviations studied in this work. The proposed B2bot_Pro parameters in this work follow a similar trend to the B2bot_NeQ and the B0_ABT, but it is not conclusive that the proposed values are equivalent to them.

  4. Prime Contractors with Awards Over $25,000 by Name, Location, and Contract Number. Fiscal Year 1993. (1079 Construction Corp-Centre Manufacturing Co Inc.). Part 1

    DTIC Science & Technology

    1994-03-01

    EZ 8 44 1- 1.. z 4L ZP u u 0 w Pa8 d 4i) 0 4.z’ 04 ~u 0 4 ) 4.~0 0:. 0W .w- w A.0 tD U.4 0) 0 4 4 4 0W IEu 40 IA. 0 W 42 4n z 4E ww W ta U4 m 4 4 U L...N 0 0kI ~II~(~ ( ~0~c ~IC I N I~(~I~0 01C 4 N( 04i..4 II .4 󈧄W00 IC0 Q 44 -4 0ൈ 00 00 0 1 .Z0 0 00ZZ 4 Is,00 00 0 0 ZI0I wc > 0 3a I Q I4b oo...1 m 3t 024.223 E g r 𔃺 4 to wi L8 z- z . 4L c o Wm 4l H z " E. w 0~ 4lL 44 W a U3 TD W xP 4 j 4 ) W V) F-4 4 4 1 w2 C. : 40 ’s U Q IN 0 1 0 0 0 0

  5. Construction of conjugative gene transfer system between E. coli and moderately thermophilic, extremely acidophilic Acidithiobacillus caldus MTH-04.

    PubMed

    Liu, Xiangmei; Lin, Jianqun; Zhang, Zheng; Bian, Jiang; Zhao, Qing; Liu, Ying; Lin, Jianqiang; Yan, Wangming

    2007-01-01

    A genetic transfer system for introducing foreign genes to biomining microorganisms is urgently needed. Thus, a conjugative gene transfer system was investigated for a moderately thermophilic, extremely acidophilic biomining bacterium, Acidithiobacillus caldus MTH-04. The broad-host-range IncP plasmids RP4 and R68.45 were transferred directly into A. caldus MTH-04 from Escherichia coli by conjugation at relatively high frequencies. Additionally the broad-host-range IncQ plasmids pJRD215, pVLT33, and pVLT35 were also transferred into A. caldus MTH-04 with the help of plasmid RP4 or strains with plasmid RP4 integrated into their chromosome, such as E. coli SM10. The Km(r) and Sm(r) selectable markers from these plasmids were successfully expressed in A. caldus MTH-04. Futhermore, the IncP and IncQ plasmids were transferred back into E. coli cells from A. caldus MTH-04, thereby confirming the initial transfer of these plasmids from E. coli to A. caldus MTH-04. All the IncP and IncQ plasmids studied were stable in A. caldus MTH-04. Consequently, this development of a conjugational system for A. caldus MTH-04 will greatly facilitate its genetic study.

  6. Q2-EVOLUTION of ΔNγ Form Factors up to 4 (GEV/C)2 from Jlab Data

    NASA Astrophysics Data System (ADS)

    Aznauryan, I. G.

    2002-12-01

    We present the results on the ratios E(3/2)1+/M(3/2)1+ and S(3/2)1+/M(3/2)1+ for the γ*N → Δ(1232) transition at Q2 ≤ 4 (GeV/c)2 extracted from the p(e,e'p)π0 cross section using two approaches: dispersion relations and modified version of unitary isobar model. The obtained results are in good agreement with the results of other analyses obtained using truncated multipole expansion at Q2 = 0.4, 0.525, 0.65, 0.75, 0.9, 1.15, 1.45, 1.8 (GeV/c)2 and within dynamical and unitary isobar models at Q2 = 2.8, 4 (GeV/c)2. According to obtained results the ratio E(3/2)1+/M(3/2)1+ remains small in all investigated region of Q2 with very unclear tendency to cross zero above 2 (GeV/c)2. The absolute value of the ratio S(3/2)1+/M(3/2)1+ is clearly increasing with increasing Q2, while it should be a constant value in the pQCD asymptotics. So, at Q2 ≤ 4 (GeV/c)2 there is no evidence of approaching pQCD regime for these ratios. None of the soft approaches gives satisfactory description of the obtained results.

  7. Distributed System Optimal Control and Parameter Estimation: Computational Techniques Using Spline Approximations.

    DTIC Science & Technology

    1982-04-01

    orthogonal proJec- differential equations (PDE) of hyperbolic or tion of Z onto ZN and N -pN’/PN. This parabolic type. Roughly speaking, in each results in...to choose a parameter from an sipative inequality in Z (such asə(q)ZZ> admissible set Q so as to yield a best fit < W < z,z> for z E Dom (.&(q))and .W...semigroup T(t;q). The approxi- sumed fixed and known and F in (1) is a N control input term , say F(t) = Bu(t). Then mating operators. S1(q) are defined

  8. Epidemic spreading in time-varying community networks

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ren, Guangming, E-mail: wangxy@dlut.edu.cn, E-mail: ren-guang-ming@163.com; Faculty of Electronic Information and Electrical Engineering, Dalian University of Technology, Dalian 116024; Wang, Xingyuan, E-mail: wangxy@dlut.edu.cn, E-mail: ren-guang-ming@163.com

    2014-06-15

    The spreading processes of many infectious diseases have comparable time scale as the network evolution. Here, we present a simple networks model with time-varying community structure, and investigate susceptible-infected-susceptible epidemic spreading processes in this model. By both theoretic analysis and numerical simulations, we show that the efficiency of epidemic spreading in this model depends intensively on the mobility rate q of the individuals among communities. We also find that there exists a mobility rate threshold q{sub c}. The epidemic will survive when q > q{sub c} and die when q < q{sub c}. These results can help understanding the impacts of human travel onmore » the epidemic spreading in complex networks with community structure.« less

  9. Treatment of reverse-osmosis concentrate of printing and dyeing wastewater by electro-oxidation process with controlled oxidation-reduction potential (ORP).

    PubMed

    Wang, Jiade; Zhang, Tian; Mei, Yu; Pan, Bingjun

    2018-06-01

    Reverse osmosis concentrate (ROC) of printing and dyeing wastewater remains as a daunting environmental issue, which is characterized by high salinity, chemical oxygen demand (COD), chroma and low biodegradability. In this study electro-oxidation process (PbO 2 /Ti electrode) coupled with oxidation-reduction potential (ORP) online monitor was applied to treat such a ROC effluent. The results show that with the increase of specific electrical charge (Q sp ), the removal efficiencies of COD, TN and chroma increased significantly at the incipience and then reached a gentle stage; the optimal total current efficiency (12.04 kWh m -3 ) was obtained with the current density of 10 mA cm -2 (Q sp , 3.0 Ah L -1 ). Meanwhile, some inorganic ions can be simultaneously removed to varying degrees. FTIR analyses indicated that the macromolecular organics were decomposed into smaller molecules. A multi-parameter linear relationship between ORP and Q sp , COD and Cl - concentration was established, which can quantitatively reflect the effect of current density, chloride ion concentration, pollutants and reaction time on the performance of the electro-oxidation system. As compared to a traditional constant-current system, the constant-ORP system developed in this study (through the back-propagation neural network [BPN] model with ORP monitoring) approximately reduced the energy cost by 24-29%. The present work is expected to provide a potential alternative in optimizing the electro-oxidation process. Copyright © 2018 Elsevier Ltd. All rights reserved.

  10. 26 CFR 302.1-4 - Computation of taxes.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... ADMINISTRATION TAXES UNDER THE INTERNATIONAL CLAIMS SETTLEMENT ACT, AS AMENDED AUGUST 9, 1955 § 302.1-4 Computation of taxes. (a) Detail of employees of the Internal Revenue Service. The Commissioner will detail... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Computation of taxes. 302.1-4 Section 302.1-4...

  11. 26 CFR 1.584-3 - Computation of common trust fund income.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 7 2010-04-01 2010-04-01 true Computation of common trust fund income. 1.584-3 Section 1.584-3 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Banking Institutions § 1.584-3 Computation of common trust...

  12. An Axisymmetric, Numerical Model for a Non-Hydrostatic Boussinesq Ocean.

    DTIC Science & Technology

    1982-12-09

    qEQsOICALL PU?OU? 06980 70’ C 060 71. C WRITE MISTeRY TAPt EVERY ITAPE STEPS 0011000 T1g C 007200 736 IF(POCISEP.ITAPE).EG.Q)wNIE(l)ITIPI.DAAIOA?Al.P...Jo C DEFINE PARIZONTAL AND VERTICAL DIFFUSION COEPPIENS 0009000 70* C 001000 710 CAEPNEooo00*OA(t3** iELT 04,3000 72. COEPZSoo.00*OZI(13.**VOELT

  13. Software Development Outsourcing Decision Support Tool with Neural Network Learning

    DTIC Science & Technology

    2004-03-01

    science, the first neuro-computer was built in 1954 by Marvin Minsky . In 1956, Dartmouth established a new research field of NN. Shortly after...04-16 50 This system was capable of recognizing letters and received much attention until 1969 when the Minsky and Papert paper discussed the

  14. Computational modeling and molecular imprinting for the development of acrylic polymers with high affinity for bile salts.

    PubMed

    Yañez, Fernando; Chianella, Iva; Piletsky, Sergey A; Concheiro, Angel; Alvarez-Lorenzo, Carmen

    2010-02-05

    This work has focused on the rational development of polymers capable of acting as traps of bile salts. Computational modeling was combined with molecular imprinting technology to obtain networks with high affinity for cholate salts in aqueous medium. The screening of a virtual library of 18 monomers, which are commonly used for imprinted networks, identified N-(3-aminopropyl)-methacrylate hydrochloride (APMA.HCl), N,N-diethylamino ethyl methacrylate (DEAEM) and ethyleneglycol methacrylate phosphate (EGMP) as suitable functional monomers with medium-to-high affinity for cholic acid. The polymers were prepared with a fix cholic acid:functional monomer mole ratio of 1:4, but with various cross-linking densities. Compared to polymers prepared without functional monomer, both imprinted and non-imprinted microparticles showed a high capability to remove sodium cholate from aqueous medium. High affinity APMA-based particles even resembled the performance of commercially available cholesterol-lowering granules. The imprinting effect was evident in most of the networks prepared, showing that computational modeling and molecular imprinting can act synergistically to improve the performance of certain polymers. Nevertheless, both the imprinted and non-imprinted networks prepared with the best monomer (APMA.HCl) identified by the modeling demonstrated such high affinity for the template that the imprinting effect was less important. The fitting of adsorption isotherms to the Freundlich model indicated that, in general, imprinting increases the population of high affinity binding sites, except when the affinity of the functional monomer for the target molecule is already very high. The cross-linking density was confirmed as a key parameter that determines the accessibility of the binding points to sodium cholate. Materials prepared with 9% mol APMA and 91% mol cross-linker showed enough affinity to achieve binding levels of up to 0.4 mmol g(-1) (i.e., 170 mg g(-1)) under flow (1 mL min(-1)) of 0.2 mM sodium cholate solution. Copyright 2009 Elsevier B.V. All rights reserved.

  15. On the decay of stratified wake: A numerical study

    NASA Astrophysics Data System (ADS)

    Chongsiripinyo, Karu; Sarkar, Sutanu

    2017-11-01

    In stratified fluids, wakes are longer lived with a significant reduction of mean velocity defect. G.R. Spedding (1997) and K.A. Brucker & S. Sarkar (2010) quantify decay rates in 3 phases, namely a near-wake (NW), a non-equilibrium (NEQ), and a quasi-two-dimensional (Q2D) region. Given U0 x-m , where U0 is centerline mean defect velocity and m is a decay rate, both studies observe mNW 2 / 3 , mNEQ 1 / 4 , and mQ 2 D 3 / 4 . Here, U∞, D, and N are the free-stream velocity, length scale of a wake generator, and constant background buoyancy frequency, respectively. However, M. Bonnier and O. Eiff (2002) observe mNEQ = 0.38 in their experiment and K. Chongsiripinyo and S. Sarkar (TSFP10) find mNEQ = 0.4 in their simulation. In the far wake, M. Bonnier and O. Eiff (2002) obtain mQ 2 D = 0.9 close to the value of m = 0.88 from Spedding et al. (1996) at similar flow conditions. Due to the lack of consistency, more evidence is required. The present study utilizes advantages of both body-inclusive (BI) and temporal-model (TF) simulations to not only resolve near-body statistics, but also to reduce computational expense needed. Decay rates of mean velocity defect and turbulence dissipation will be presented.

  16. Fast algorithm for computing a primitive /2 to power p + 1/p-th root of unity in GF/q squared/

    NASA Technical Reports Server (NTRS)

    Reed, I. S.; Truong, T. K.; Miller, R. L.

    1978-01-01

    A quick method is described for finding the primitive (2 to power p + 1)p-th root of unity in the Galois field GF(q squared), where q = (2 to power p) - 1 and is known as a Mersenne prime. Determination of this root is necessary to implement complex integer transforms of length (2 to power k) times p over the Galois field, with k varying between 3 and p + 1.

  17. A Q-backpropagated time delay neural network for diagnosing severity of gait disturbances in Parkinson's disease.

    PubMed

    Nancy Jane, Y; Khanna Nehemiah, H; Arputharaj, Kannan

    2016-04-01

    Parkinson's disease (PD) is a movement disorder that affects the patient's nervous system and health-care applications mostly uses wearable sensors to collect these data. Since these sensors generate time stamped data, analyzing gait disturbances in PD becomes challenging task. The objective of this paper is to develop an effective clinical decision-making system (CDMS) that aids the physician in diagnosing the severity of gait disturbances in PD affected patients. This paper presents a Q-backpropagated time delay neural network (Q-BTDNN) classifier that builds a temporal classification model, which performs the task of classification and prediction in CDMS. The proposed Q-learning induced backpropagation (Q-BP) training algorithm trains the Q-BTDNN by generating a reinforced error signal. The network's weights are adjusted through backpropagating the generated error signal. For experimentation, the proposed work uses a PD gait database, which contains gait measures collected through wearable sensors from three different PD research studies. The experimental result proves the efficiency of Q-BP in terms of its improved classification accuracy of 91.49%, 92.19% and 90.91% with three datasets accordingly compared to other neural network training algorithms. Copyright © 2016 Elsevier Inc. All rights reserved.

  18. Common Variants in the MKL1 Gene Confer Risk of Schizophrenia

    PubMed Central

    Luo, Xiong-jian; Huang, Liang; van den Oord, Edwin J.; Aberg, Karolina A.; Gan, Lin; Zhao, Zhongming; Yao, Yong-Gang

    2015-01-01

    Genome-wide association studies (GWAS) of schizophrenia have identified multiple risk variants with robust association signals for schizophrenia. However, these variants could explain only a small proportion of schizophrenia heritability. Furthermore, the effect size of these risk variants is relatively small (eg, most of them had an OR less than 1.2), suggesting that additional risk variants may be detected when increasing sample size in analysis. Here, we report the identification of a genome-wide significant schizophrenia risk locus at 22q13.1 by combining 2 large-scale schizophrenia cohort studies. Our meta-analysis revealed that 7 single nucleotide polymorphism (SNPs) on chromosome 22q13.1 reached the genome-wide significance level (P < 5.0×10–8) in the combined samples (a total of 38441 individuals). Among them, SNP rs6001946 had the most significant association with schizophrenia (P = 2.04×10–8). Interestingly, all 7 SNPs are in high linkage disequilibrium and located in the MKL1 gene. Expression analysis showed that MKL1 is highly expressed in human and mouse brains. We further investigated functional links between MKL1 and proteins encoded by other schizophrenia susceptibility genes in the whole human protein interaction network. We found that MKL1 physically interacts with GSK3B, a protein encoded by a well-characterized schizophrenia susceptibility gene. Collectively, our results revealed that genetic variants in MKL1 might confer risk to schizophrenia. Further investigation of the roles of MKL1 in the pathogenesis of schizophrenia is warranted. PMID:25380769

  19. 26 CFR 1.167(b)-0 - Methods of computing depreciation.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 2 2014-04-01 2014-04-01 false Methods of computing depreciation. 1.167(b)-0....167(b)-0 Methods of computing depreciation. (a) In general. Any reasonable and consistently applied method of computing depreciation may be used or continued in use under section 167. Regardless of the...

  20. 26 CFR 1.167(b)-0 - Methods of computing depreciation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 2 2010-04-01 2010-04-01 false Methods of computing depreciation. 1.167(b)-0....167(b)-0 Methods of computing depreciation. (a) In general. Any reasonable and consistently applied method of computing depreciation may be used or continued in use under section 167. Regardless of the...

  1. 26 CFR 31.3502-1 - Nondeductibility of taxes in computing taxable income.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 15 2010-04-01 2010-04-01 false Nondeductibility of taxes in computing taxable... 1954) § 31.3502-1 Nondeductibility of taxes in computing taxable income. For provisions relating to the nondeductibility, in computing taxable income under subtitle A, of the taxes imposed by sections 3101, 3201, and...

  2. Ongoing data reduction, theoretical studies and supporting research in magnetospheric physics

    NASA Technical Reports Server (NTRS)

    Scarf, F. L.; Greenstadt, E. W.

    1984-01-01

    Data from ISEE-3, Pioneer Venus Orbiter, and Voyager 1 and 2 were analyzed. The predictability of local shock macrostructure at ISEE-1, at the Earth's bow shock, from solar wind measurements made up-stream by ISEE-3, was conducted using computer graphic format. Morphology of quasi-parallel shock was reviewed. The review attempted to interrelate various measurements and computations involving the q-parallel structure and foreshock elements connected to it. A new classification for q-parallel morphology was suggested.

  3. MicroRNA Dysregulation, Gene Networks, and Risk for Schizophrenia in 22q11.2 Deletion Syndrome

    PubMed Central

    Merico, Daniele; Costain, Gregory; Butcher, Nancy J.; Warnica, William; Ogura, Lucas; Alfred, Simon E.; Brzustowicz, Linda M.; Bassett, Anne S.

    2014-01-01

    The role of microRNAs (miRNAs) in the etiology of schizophrenia is increasingly recognized. Microdeletions at chromosome 22q11.2 are recurrent structural variants that impart a high risk for schizophrenia and are found in up to 1% of all patients with schizophrenia. The 22q11.2 deletion region overlaps gene DGCR8, encoding a subunit of the miRNA microprocessor complex. We identified miRNAs overlapped by the 22q11.2 microdeletion and for the first time investigated their predicted target genes, and those implicated by DGCR8, to identify targets that may be involved in the risk for schizophrenia. The 22q11.2 region encompasses seven validated or putative miRNA genes. Employing two standard prediction tools, we generated sets of predicted target genes. Functional enrichment profiles of the 22q11.2 region miRNA target genes suggested a role in neuronal processes and broader developmental pathways. We then constructed a protein interaction network of schizophrenia candidate genes and interaction partners relevant to brain function, independent of the 22q11.2 region miRNA mechanisms. We found that the predicted gene targets of the 22q11.2 deletion miRNAs, and targets of the genome-wide miRNAs predicted to be dysregulated by DGCR8 hemizygosity, were significantly represented in this schizophrenia network. The findings provide new insights into the pathway from 22q11.2 deletion to expression of schizophrenia, and suggest that hemizygosity of the 22q11.2 region may have downstream effects implicating genes elsewhere in the genome that are relevant to the general schizophrenia population. These data also provide further support for the notion that robust genetic findings in schizophrenia may converge on a reasonable number of final pathways. PMID:25484875

  4. Measurement of the W-pair cross-section and of the W mass in e+ e- interactions at 172 GeV

    NASA Astrophysics Data System (ADS)

    DELPHI Collaboration; Abreu, P.; et al.

    From a data sample of 9.98 pb-1 integrated luminosity, collected by DELPHI at a centre-of-mass energy of 172 GeV, 118 events were selected as W-pair candidates. From these, the branching fraction Br(W ->q ) was measured to be 0.660+0.036-0.037 ( {stat.}) +/- 0.009 ( {syst.}) and the cross-section for the doubly resonant process hrm e+ e- -> W+ W- to be 11.58+1.44-1.35 ( {stat.}) +/- 0.32 ( {syst.}) pb. The mass of the W boson, obtained from direct reconstruction of the invariant mass of the fermion pairs in the decays { WW -> lν q {q}} and { WW -> q {q}q {q}}, was determined to be mW = \\: 80.22 \\: +/- \\: 0.41 ( {stat.}) \\: +/- 0.04 ( {syst.}) \\: m 0.05 ( {int.}) \\: +/- 0.03 ( {LEP})\\: {GeV}/c2, where ``int.'' denotes the uncertainty from interconnection effects like colour reconnection and Bose-Einstein interference. Combined with the W mass obtained from the cross-sections measured by DELPHI at threshold, a value of mW = \\: 80.33 \\: +/- \\: 0.30 ( {stat.}) \\: +/- 0.05 ({syst.}) \\: +/- \\: 0.03 ( {int.}) \\: +/- \\: 0.03 ( {LEP}) \\: {GeV}/c2 was found.

  5. Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia

    PubMed Central

    Law, Philip J.; Berndt, Sonja I.; Speedy, Helen E.; Camp, Nicola J.; Sava, Georgina P.; Skibola, Christine F.; Holroyd, Amy; Joseph, Vijai; Sunter, Nicola J.; Nieters, Alexandra; Bea, Silvia; Monnereau, Alain; Martin-Garcia, David; Goldin, Lynn R.; Clot, Guillem; Teras, Lauren R.; Quintela, Inés; Birmann, Brenda M.; Jayne, Sandrine; Cozen, Wendy; Majid, Aneela; Smedby, Karin E.; Lan, Qing; Dearden, Claire; Brooks-Wilson, Angela R.; Hall, Andrew G.; Purdue, Mark P.; Mainou-Fowler, Tryfonia; Vajdic, Claire M.; Jackson, Graham H.; Cocco, Pierluigi; Marr, Helen; Zhang, Yawei; Zheng, Tongzhang; Giles, Graham G.; Lawrence, Charles; Call, Timothy G.; Liebow, Mark; Melbye, Mads; Glimelius, Bengt; Mansouri, Larry; Glenn, Martha; Curtin, Karen; Diver, W Ryan; Link, Brian K.; Conde, Lucia; Bracci, Paige M.; Holly, Elizabeth A.; Jackson, Rebecca D.; Tinker, Lesley F.; Benavente, Yolanda; Boffetta, Paolo; Brennan, Paul; Maynadie, Marc; McKay, James; Albanes, Demetrius; Weinstein, Stephanie; Wang, Zhaoming; Caporaso, Neil E.; Morton, Lindsay M.; Severson, Richard K.; Riboli, Elio; Vineis, Paolo; Vermeulen, Roel C. H.; Southey, Melissa C.; Milne, Roger L.; Clavel, Jacqueline; Topka, Sabine; Spinelli, John J.; Kraft, Peter; Ennas, Maria Grazia; Summerfield, Geoffrey; Ferri, Giovanni M.; Harris, Robert J.; Miligi, Lucia; Pettitt, Andrew R.; North, Kari E.; Allsup, David J.; Fraumeni, Joseph F.; Bailey, James R.; Offit, Kenneth; Pratt, Guy; Hjalgrim, Henrik; Pepper, Chris; Chanock, Stephen J.; Fegan, Chris; Rosenquist, Richard; de Sanjose, Silvia; Carracedo, Angel; Dyer, Martin J. S.; Catovsky, Daniel; Campo, Elias; Cerhan, James R.; Allan, James M.; Rothman, Nathanial; Houlston, Richard; Slager, Susan

    2017-01-01

    Several chronic lymphocytic leukaemia (CLL) susceptibility loci have been reported; however, much of the heritable risk remains unidentified. Here we perform a meta-analysis of six genome-wide association studies, imputed using a merged reference panel of 1,000 Genomes and UK10K data, totalling 6,200 cases and 17,598 controls after replication. We identify nine risk loci at 1p36.11 (rs34676223, P=5.04 × 10−13), 1q42.13 (rs41271473, P=1.06 × 10−10), 4q24 (rs71597109, P=1.37 × 10−10), 4q35.1 (rs57214277, P=3.69 × 10−8), 6p21.31 (rs3800461, P=1.97 × 10−8), 11q23.2 (rs61904987, P=2.64 × 10−11), 18q21.1 (rs1036935, P=3.27 × 10−8), 19p13.3 (rs7254272, P=4.67 × 10−8) and 22q13.33 (rs140522, P=2.70 × 10−9). These new and established risk loci map to areas of active chromatin and show an over-representation of transcription factor binding for the key determinants of B-cell development and immune response. PMID:28165464

  6. High Resolution Genome-Wide Analysis of Chromosomal Alterations in Burkitt's Lymphoma

    PubMed Central

    Toujani, Saloua; Dessen, Philippe; Ithzar, Nathalie; Danglot, Gisèle; Richon, Catherine; Vassetzky, Yegor; Robert, Thomas; Lazar, Vladimir; Bosq, Jacques; Da Costa, Lydie; Pérot, Christine; Ribrag, Vincent; Patte, Catherine; Wiels, Jöelle; Bernheim, Alain

    2009-01-01

    Additional chromosomal abnormalities are currently detected in Burkitt's lymphoma. They play major roles in the progression of BL and in prognosis. The genes involved remain elusive. A whole-genome oligonucleotide array CGH analysis correlated with karyotype and FISH was performed in a set of 27 Burkitt's lymphoma-derived cell lines and primary tumors. More than half of the 145 CNAs<2 Mb were mapped to Mendelian CNVs, including GSTT1, glutathione s-transferase and BIRC6, an anti-apoptotic protein, possibly predisposing to some cancers. Somatic cell line-specific CNVs localized to the IG locus were consistently observed with the 244 K aCGH platform. Among 136 CNAs >2 Mb, gains were found in 1q (12/27), 13q (7/27), 7q (6/27), 8q(4/27), 2p (3/27), 11q (2/27) and 15q (2/27). Losses were found in 3p (5/27), 4p (4/27), 4q (4/27), 9p (4/27), 13q (4/27), 6p (3/27), 17p (3/27), 6q (2/27),11pterp13 (2/27) and 14q12q21.3 (2/27). Twenty one minimal critical regions (MCR), (range 0.04–71.36 Mb), were delineated in tumors and cell lines. Three MCRs were localized to 1q. The proximal one was mapped to 1q21.1q25.2 with a 6.3 Mb amplicon (1q21.1q21.3) harboring BCA2 and PIAS3. In the other 2 MCRs, 1q32.1 and 1q44, MDM4 and AKT3 appeared as possible drivers of these gains respectively. The 13q31.3q32.1 <89.58–96.81> MCR contained an amplicon and ABCC4 might be the driver of this amplicon. The 40 Kb 2p16.1 <60.96–61> MCR was the smallest gained MCR and specifically encompassed the REL oncogene which is already implicated in B cell lymphomas. The most frequently deleted MCR was 3p14.1 <60.43–60.53> that removed the fifth exon of FHIT. Further investigations which combined gene expression and functional studies are essential to understand the lymphomagenesis mechanism and for the development of more effective, targeted therapeutic strategies. PMID:19759907

  7. High resolution genome-wide analysis of chromosomal alterations in Burkitt's lymphoma.

    PubMed

    Toujani, Saloua; Dessen, Philippe; Ithzar, Nathalie; Danglot, Gisèle; Richon, Catherine; Vassetzky, Yegor; Robert, Thomas; Lazar, Vladimir; Bosq, Jacques; Da Costa, Lydie; Pérot, Christine; Ribrag, Vincent; Patte, Catherine; Wiels, Jöelle; Bernheim, Alain

    2009-09-17

    Additional chromosomal abnormalities are currently detected in Burkitt's lymphoma. They play major roles in the progression of BL and in prognosis. The genes involved remain elusive. A whole-genome oligonucleotide array CGH analysis correlated with karyotype and FISH was performed in a set of 27 Burkitt's lymphoma-derived cell lines and primary tumors. More than half of the 145 CNAs<2 Mb were mapped to Mendelian CNVs, including GSTT1, glutathione s-transferase and BIRC6, an anti-apoptotic protein, possibly predisposing to some cancers. Somatic cell line-specific CNVs localized to the IG locus were consistently observed with the 244 K aCGH platform. Among 136 CNAs >2 Mb, gains were found in 1q (12/27), 13q (7/27), 7q (6/27), 8q(4/27), 2p (3/27), 11q (2/27) and 15q (2/27). Losses were found in 3p (5/27), 4p (4/27), 4q (4/27), 9p (4/27), 13q (4/27), 6p (3/27), 17p (3/27), 6q (2/27),11pterp13 (2/27) and 14q12q21.3 (2/27). Twenty one minimal critical regions (MCR), (range 0.04-71.36 Mb), were delineated in tumors and cell lines. Three MCRs were localized to 1q. The proximal one was mapped to 1q21.1q25.2 with a 6.3 Mb amplicon (1q21.1q21.3) harboring BCA2 and PIAS3. In the other 2 MCRs, 1q32.1 and 1q44, MDM4 and AKT3 appeared as possible drivers of these gains respectively. The 13q31.3q32.1 <89.58-96.81> MCR contained an amplicon and ABCC4 might be the driver of this amplicon. The 40 Kb 2p16.1 <60.96-61> MCR was the smallest gained MCR and specifically encompassed the REL oncogene which is already implicated in B cell lymphomas. The most frequently deleted MCR was 3p14.1 <60.43-60.53> that removed the fifth exon of FHIT. Further investigations which combined gene expression and functional studies are essential to understand the lymphomagenesis mechanism and for the development of more effective, targeted therapeutic strategies.

  8. Photospheric Current Spikes and Their Possible Association with Flares - Results from an HMI Data Driven Model

    NASA Technical Reports Server (NTRS)

    Goodman, Michael; Kwan, Chiman; Ayhan, Bulent; Shang, Eric L.

    2016-01-01

    A data driven, near photospheric magnetohydrodynamic model predicts spikes in the horizontal current density, and associated resistive heating rate per unit volume Q. The spikes appear as increases by orders of magnitude above background values in neutral line regions (NLRs) of active regions (ARs). The largest spikes typically occur a few hours to a few days prior to M or X flares. The spikes correspond to large vertical derivatives of the horizontal magnetic field. The model takes as input the photospheric magnetic field observed by the Helioseismic & Magnetic Imager (HMI) on the Solar Dynamics Observatory (SDO) satellite. This 2.5 D field is used to determine an analytic expression for a 3 D magnetic field, from which the current density, vector potential, and electric field are computed in every AR pixel for 14 ARs. The field is not assumed to be force-free. The spurious 6, 12, and 24 hour Doppler periods due to SDO orbital motion are filtered out of the time series of the HMI magnetic field for each pixel using a band pass filter. The subset of spikes analyzed at the pixel level are found to occur on HMI and granulation scales of 1 arcsec and 12 minutes. Spikes are found in ARs with and without M or X flares, and outside as well as inside NLRs, but the largest spikes are localized in the NLRs of ARs with M or X flares. The energy to drive the heating associated with the largest current spikes comes from bulk flow kinetic energy, not the electromagnetic field, and the current density is highly non-force free. The results suggest that, in combination with the model, HMI is revealing strong, convection driven, non-force free heating events on granulation scales, and that it is plausible these events are correlated with subsequent M or X flares. More and longer time series need to be analyzed to determine if such a correlation exists. Above an AR dependent threshold value of Q, the number of events N(Q) with heating rates greater than or equal to Q obeys a scale invariant power law distribution for each AR given by N(Q) varies Q(sup -s), where 0.40 less than or equal to S less than or equal to 0.53, with a mean and standard deviation across the 14 ARs of 0.47 and 0.045, showing there is little variation of S from one AR to another. These properties of N(Q) are in close agreement with those of the distribution N(E) for the total energy E of solar flares, determined from observations to be N(E) = constant x E(sup -alpha). From observations of nanoflares in the 0.7 to 4 MK range, and from observations of flares in hard X-rays, it is found that 0.51 less than or equal to alpha less than or equal to 0.57, and 0.4 less than or equal to alpha less than or equal to 0.6, respectively (Crosby et al. 1993, Sol. Phys., 143, 275; Aschwanden & Parnell 2002, ApJ, 572, 1048). Observations also show that, as is found here for the exponent S, there is little variation of alpha with AR (Wheatland 2000, ApJ, 532, 1209), indicating N(E) and N(Q) are largely independent of individual properties of ARs such as area, total magnetic flux, and distribution of current density (i.e. non-potentiality). Therefore the power law scaling of the photospheric heating rate Q computed here on granulation scales is essentially identical to that found for coronal observations of flare energies on scales 1-2 orders of magnitude larger. This suggests the physical mechanisms that cause Q and coronal flares are closely related. It seems likely that Q is the signature of a magnetic reconnection process in an energy range and volume orders of magnitude smaller than those of flares. In this context, at least the larger spikes in Q might be signatures of UV photospheric or lower chromospheric bombs in which plasma is heated to temperatures approximately 10(exp -5) K (Peter et al. 2014, Science 346, 1255726; Judge 2015, ApJ, 808, 116). In addition, lattice based avalanche simulations of flare energy release predict 0.4 less than or equal to alpha less than or equal to 0.5, while analytic, fractal-diffusive self-organized criticality models predict 0.4 less than or equal to alpha less than or equal to 0.67, in excellent agreement with observations, and the results presented here (Aschwanden & Parnell 2002, ApJ, 572, 1048; Aschwanden 2012, A&A, 539, A2; Aschwanden 2013, in "Self Organized Criticality Systems"; Aschwanden et al. 2016, SSR, 198, 47).

  9. 26 CFR 301.6014-1 - Income tax return-tax not computed by taxpayer.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 18 2010-04-01 2010-04-01 false Income tax return-tax not computed by taxpayer. 301.6014-1 Section 301.6014-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY... Records § 301.6014-1 Income tax return—tax not computed by taxpayer. For provisions relating to the...

  10. 26 CFR 1.809-10 - Computation of equity base.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 8 2013-04-01 2013-04-01 false Computation of equity base. 1.809-10 Section 1... (CONTINUED) INCOME TAXES (CONTINUED) Gain and Loss from Operations § 1.809-10 Computation of equity base. (a) In general. For purposes of section 809, the equity base of a life insurance company includes the...

  11. 26 CFR 1.809-10 - Computation of equity base.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 8 2011-04-01 2011-04-01 false Computation of equity base. 1.809-10 Section 1... (CONTINUED) INCOME TAXES (CONTINUED) Gain and Loss from Operations § 1.809-10 Computation of equity base. (a) In general. For purposes of section 809, the equity base of a life insurance company includes the...

  12. 26 CFR 1.809-10 - Computation of equity base.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 8 2012-04-01 2012-04-01 false Computation of equity base. 1.809-10 Section 1... (CONTINUED) INCOME TAXES (CONTINUED) Gain and Loss from Operations § 1.809-10 Computation of equity base. (a) In general. For purposes of section 809, the equity base of a life insurance company includes the...

  13. 26 CFR 1.809-10 - Computation of equity base.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 8 2010-04-01 2010-04-01 false Computation of equity base. 1.809-10 Section 1... (CONTINUED) INCOME TAXES Gain and Loss from Operations § 1.809-10 Computation of equity base. (a) In general. For purposes of section 809, the equity base of a life insurance company includes the amount of any...

  14. 26 CFR 1.988-2 - Recognition and computation of exchange gain or loss.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 10 2014-04-01 2013-04-01 true Recognition and computation of exchange gain or... and computation of exchange gain or loss. (a) Disposition of nonfunctional currency—(1) Recognition of exchange gain or loss—(i) In general. Except as otherwise provided in this section, § 1.988-1(a)(7)(ii...

  15. 26 CFR 1.988-2 - Recognition and computation of exchange gain or loss.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 26 Internal Revenue 10 2013-04-01 2013-04-01 false Recognition and computation of exchange gain or... and computation of exchange gain or loss. (a) Disposition of nonfunctional currency—(1) Recognition of exchange gain or loss—(i) In general. Except as otherwise provided in this section, § 1.988-1(a)(7)(ii...

  16. 26 CFR 1.988-2 - Recognition and computation of exchange gain or loss.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 26 Internal Revenue 10 2012-04-01 2012-04-01 false Recognition and computation of exchange gain or... and computation of exchange gain or loss. (a) Disposition of nonfunctional currency—(1) Recognition of exchange gain or loss—(i) In general. Except as otherwise provided in this section, § 1.988-1(a)(7)(ii...

  17. Network Monitoring in the age of the Cloud

    NASA Astrophysics Data System (ADS)

    Ciuffoletti, Augusto

    Network virtualization plays a relevant role in provisioning an Infrastructure as a Service (IaaS), implementing the fabric that interconnects virtual components. We identify the standard protocol IEEE802.1Q, that describes Virtual LAN (VLAN) functionalities, as a cornerstone in this architecture.

  18. Mathematical Modelling of Waveguiding Techniques and Electron Transport. Volume 2.

    DTIC Science & Technology

    1984-01-01

    0 2 4! :1. 2 40 4 Z K04 ! -. t4. ’A. ’..44>. ZAw 4 o I .P. w AU W. 2OMD.->EK’ 0 2 c’* ’ w a rig;- G! -󈧈.z su t2 09 .4’ P’ 2 ULM.. 24- -1!044 n04 wt...a 44Nz w Z2V 00 .4- U 0 i- Owlt U. -Ia 040033 ’. Urna44e + -- -a -. -q a nu CuS In - ) 0U~ I N0 0 2 4 tUN + tot +. ++.a W ~ a 3 1 04 A a ,.a c’-a3>-0

  19. Using Antelope and Seiscomp in the framework of the Romanian Seismic Network

    NASA Astrophysics Data System (ADS)

    Marius Craiu, George; Craiu, Andreea; Marmureanu, Alexandru; Neagoe, Cristian

    2014-05-01

    The National Institute for Earth Physics (NIEP) operates a real-time seismic network designed to monitor the seismic activity on the Romania territory, dominated by the Vrancea intermediate-depth (60-200 km) earthquakes. The NIEP real-time network currently consists of 102 stations and two seismic arrays equipped with different high quality digitizers (Kinemetrics K2, Quanterra Q330, Quanterra Q330HR, PS6-26, Basalt), broadband and short period seismometers (CMG3ESP, CMG40T, KS2000, KS54000, KS2000, CMG3T, STS2, SH-1, S13, Mark l4c, Ranger, Gs21, Mark 22) and acceleration sensors (Episensor Kinemetrics). The primary goal of the real-time seismic network is to provide earthquake parameters from more broad-band stations with a high dynamic range, for more rapid and accurate computation of the locations and magnitudes of earthquakes. The Seedlink and AntelopeTM program packages are completely automated Antelope seismological system is run at the Data Center in Măgurele. The Antelope data acquisition and processing software is running for real-time processing and post processing. The Antelope real-time system provides automatic event detection, arrival picking, event location, and magnitude calculation. It also provides graphical displays and automatic location within near real time after a local, regional or teleseismic event has occurred SeisComP 3 is another automated system that is run at the NIEP and which provides the following features: data acquisition, data quality control, real-time data exchange and processing, network status monitoring, issuing event alerts, waveform archiving and data distribution, automatic event detection and location, easy access to relevant information about stations, waveforms, and recent earthquakes. The main goal of this paper is to compare both of these data acquisitions systems in order to improve their detection capabilities, location accuracy, magnitude and depth determination and reduce the RMS and other location errors.

  20. 26 CFR 1.988-2 - Recognition and computation of exchange gain or loss.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 10 2011-04-01 2011-04-01 false Recognition and computation of exchange gain or... (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Export Trade Corporations § 1.988-2 Recognition and computation of exchange gain or loss. (a) Disposition of nonfunctional currency—(1) Recognition of...

  1. 26 CFR 1.988-2 - Recognition and computation of exchange gain or loss.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 10 2010-04-01 2010-04-01 false Recognition and computation of exchange gain or... (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Export Trade Corporations § 1.988-2 Recognition and computation of exchange gain or loss. (a) Disposition of nonfunctional currency—(1) Recognition of exchange...

  2. Automated Performance Monitoring and Assessment for DCS Digital Systems

    DTIC Science & Technology

    1980-07-01

    in an automated technical con-. trol environnrunt. j UNCLASSIFIED SECURITY CLASSIFICATION OF I , PAGE(Wh n O tD . E e d) ACKNOWLEDGEMENT This program...5-2 Second Level MUX TD -1193 Alarms 5-3 5-3 First Level MUX TD -1192 Alarms 5-4 5.-4 Submultiplexer TDM-1251 Alarms 5-5 5 RF Distribution System...i 0 (0: I- O)’dU 04i (0) 0 0a 04 U) (04 04r 04 r- (O 0) 0) 41 ~ 0) 0H (z (0 0) Q) 4J a r- ) -4’ iHQ ) w .41 Q) > 4-4 !O ~ -4 ) > 114 > 44 >4 UU O4 u

  3. A performance comparison of current HPC systems: Blue Gene/Q, Cray XE6 and InfiniBand systems

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kerbyson, Darren J.; Barker, Kevin J.; Vishnu, Abhinav

    2014-01-01

    We present here a performance analysis of three of current architectures that have become commonplace in the High Performance Computing world. Blue Gene/Q is the third generation of systems from IBM that use modestly performing cores but at large-scale in order to achieve high performance. The XE6 is the latest in a long line of Cray systems that use a 3-D topology but the first to use its Gemini interconnection network. InfiniBand provides the flexibility of using compute nodes from many vendors that can be connected in many possible topologies. The performance characteristics of each vary vastly, and the waymore » in which nodes are allocated in each type of system can significantly impact on achieved performance. In this work we compare these three systems using a combination of micro-benchmarks and a set of production applications. In addition we also examine the differences in performance variability observed on each system and quantify the lost performance using a combination of both empirical measurements and performance models. Our results show that significant performance can be lost in normal production operation of the Cray XE6 and InfiniBand Clusters in comparison to Blue Gene/Q.« less

  4. Connecting Neuronal Cell Protective Pathways and Drug Combinations in a Huntington's Disease Model through the Application of Quantitative Systems Pharmacology.

    PubMed

    Pei, Fen; Li, Hongchun; Henderson, Mark J; Titus, Steven A; Jadhav, Ajit; Simeonov, Anton; Cobanoglu, Murat Can; Mousavi, Seyed H; Shun, Tongying; McDermott, Lee; Iyer, Prema; Fioravanti, Michael; Carlisle, Diane; Friedlander, Robert M; Bahar, Ivet; Taylor, D Lansing; Lezon, Timothy R; Stern, Andrew M; Schurdak, Mark E

    2017-12-19

    Quantitative Systems Pharmacology (QSP) is a drug discovery approach that integrates computational and experimental methods in an iterative way to gain a comprehensive, unbiased understanding of disease processes to inform effective therapeutic strategies. We report the implementation of QSP to Huntington's Disease, with the application of a chemogenomics platform to identify strategies to protect neuronal cells from mutant huntingtin induced death. Using the STHdh Q111 cell model, we investigated the protective effects of small molecule probes having diverse canonical modes-of-action to infer pathways of neuronal cell protection connected to drug mechanism. Several mechanistically diverse protective probes were identified, most of which showed less than 50% efficacy. Specific combinations of these probes were synergistic in enhancing efficacy. Computational analysis of these probes revealed a convergence of pathways indicating activation of PKA. Analysis of phospho-PKA levels showed lower cytoplasmic levels in STHdh Q111 cells compared to wild type STHdh Q7 cells, and these levels were increased by several of the protective compounds. Pharmacological inhibition of PKA activity reduced protection supporting the hypothesis that protection may be working, in part, through activation of the PKA network. The systems-level studies described here can be broadly applied to any discovery strategy involving small molecule modulation of disease phenotype.

  5. Dielectric and piezoelectric properties of CeO2-added nonstoichiometric (Na0.5K0.5)0.97(Nb0.96Sb0.04)O3 ceramics for piezoelectric energy harvesting device applications.

    PubMed

    Oh, Youngkwang; Noh, Jungrae; Yoo, Juhyun; Kang, Jinhee; Hwang, Larkhoon; Hong, Jaeil

    2011-09-01

    In this study, nonstoichiometric (Na(0.5)K(0.5))(0.97)(Nb(0.96)Sb(0.04))O(3) ceramics were fabricated and their dielectric and piezoelectric properties were investigated according to the CeO(2) addition. In this ceramic composition, CeO(2) addition improved sinterability, electromechanical coupling factor k(p), mechanical quality factor Q(m), piezoelectric constant d(33), and g(33). At the sintering temperature of 1100°C, for the 0.2wt% CeO(2) added specimen, the optimum values of density = 4.359 g/cm(3), k(p) = 0.443, Q(m) = 588, ε(r) = 444, d(33) = 159 pC/N, and g(33) = 35 × 10(-3) V·m/N, were obtained. A piezoelectric energy harvesting device using 0.2 wt% CeO(2)- added lead-free (K(0.5)Na(0.5))(0.97)(Nb(0.96)Sb(0.04))O(3) ceramics and a rectifying circuit for energy harvesting were fabricated and their electrical characteristics were investigated. Under an external vibration acceleration of 0.7 g, when the mass, the frequency of vibration generator, and matching load resistance were 2.4 g, 70 Hz, and 721 Ω, respectively, output voltage and power of piezoelectric harvesting device indicated the optimum values of 24.6 mV(rms) and 0.839 μW, respectively-suitable for application as the electric power source of a ubiquitous sensor network (USN) sensor node.

  6. Automatic learning of rules. A practical example of using artificial intelligence to improve computer-based detection of myocardial infarction and left ventricular hypertrophy in the 12-lead ECG.

    PubMed

    Kaiser, W; Faber, T S; Findeis, M

    1996-01-01

    The authors developed a computer program that detects myocardial infarction (MI) and left ventricular hypertrophy (LVH) in two steps: (1) by extracting parameter values from a 10-second, 12-lead electrocardiogram, and (2) by classifying the extracted parameter values with rule sets. Every disease has its dedicated set of rules. Hence, there are separate rule sets for anterior MI, inferior MI, and LVH. If at least one rule is satisfied, the disease is said to be detected. The computer program automatically develops these rule sets. A database (learning set) of healthy subjects and patients with MI, LVH, and mixed MI+LVH was used. After defining the rule type, initial limits, and expected quality of the rules (positive predictive value, minimum number of patients), the program creates a set of rules by varying the limits. The general rule type is defined as: disease = lim1l < p1 < or = lim1u and lim2l < p2 < or = lim2u and ... limnl < pn < or = limnu. When defining the rule types, only the parameters (p1 ... pn) that are known as clinical electrocardiographic criteria (amplitudes [mV] of Q, R, and T waves and ST-segment; duration [ms] of Q wave; frontal angle [degrees]) were used. This allowed for submitting the learned rule sets to an independent investigator for medical verification. It also allowed the creation of explanatory texts with the rules. These advantages are not offered by the neurons of a neural network. The learned rules were checked against a test set and the following results were obtained: MI: sensitivity 76.2%, positive predictive value 98.6%; LVH: sensitivity 72.3%, positive predictive value 90.9%. The specificity ratings for MI are better than 98%; for LVH, better than 90%.

  7. Baby Boomers and Birth Certificates: Early-Life Socioeconomic Status and Cancer Risk in Adulthood.

    PubMed

    Stroup, Antoinette M; Herget, Kimberly A; Hanson, Heidi A; Reed, Diana Lane; Butler, Jared T; Henry, Kevin A; Harrell, C Janna; Sweeney, Carol; Smith, Ken R

    2017-01-01

    Early-life socioeconomic status (SES) may play a role in cancer risk in adulthood. However, measuring SES retrospectively presents challenges. Parental occupation on the birth certificate is a novel method of ascertaining early-life SES that has not been applied in cancer epidemiology. For a Baby-Boom cohort born from 1945-1959 in two Utah counties, individual-level Nam-Powers SES (Np-SES) was derived from parental industry/occupation reported on birth certificates. Neighborhood SES was estimated from average household income of census tract at birth. Cancer incidence was determined by linkage to Utah Cancer Registry records through the Utah Population Database. Hazard ratios (HR) for cancer risk by SES quartile were estimated using Cox proportional hazards regression. Females with low Np-SES at birth had lower risk of breast cancer compared with those in the highest Np-SES group [HR Q1/Q4 = 0.83; 95% confidence interval (CI), 0.72-0.97; HR Q2/Q4 = 0.81; 95% CI, 0.69-0.96]. Np-SES was inversely associated with melanoma (HR Q1/Q4 = 0.81; 95% CI, 0.67-0.98) and prostate cancer (HR Q1/Q4 = 0.70; 95% CI, 0.56-0.88). Women born into lower SES neighborhoods had significantly increased risk for invasive cervical cancer (HR Q1/Q4 = 1.44; 95% CI, 1.12-1.85; HR Q2/Q4 = 1.33; 95% CI, 1.04-1.72). Neighborhood SES had similar effects for melanoma and prostate cancers, but was not associated with female breast cancer. We found no association with SES for pancreas, lung, and colon and rectal cancers. Individual SES derived from parental occupation at birth was associated with altered risk for several cancer sites. This novel methodology can contribute to improved understanding of the role of early-life SES on cancer risk. Cancer Epidemiol Biomarkers Prev; 26(1); 75-84. ©2016 AACR. ©2016 American Association for Cancer Research.

  8. All Prime Contract Awards by State or Country, Place, and Contractor, FY 88. Part 14. (Aberdeen, North Carolina-Zanesville, Ohio)

    DTIC Science & Technology

    1988-01-01

    a) > fr wUO wua w U.1 W 0 w 0C(00O-4 C 0 a. W(1 La- 0--cl - (n U, -.1 i.* .- " I,.1- wI- 44 Z(0(01- C(0.-4 l(0 w0 1-0 co 0Nz W 00 W(1-lZ Cr-Z um1 00...l N N l N 1 N N-4.-4 ’-4-4.-IN -4 1 00r- I Nl NI N1 N" -4-4 C1 "NNNli- I01( Q L I 1 -4 -4 - 4 -4 fr -- CNNN U) 100’V I I1Q000 I N N1 -4 -4 N4 N 04NN...4 .- 4 . 4 4- I 00(0 I C~ -r- I- r 0-r-r.r- fr - l P- Qr- r- or- ar- >J- >j- >,t- r- r- r- . DO(0 o ’n I4400000 40000000 1000 440 m0 m 0 mU0

  9. Using Microsoft Excel to compute the 5% overall site X/Q value and the 95th percentile of the distribution of doses to the nearest maximally exposed offsite individual (MEOI).

    PubMed

    Vickers, Linda D

    2010-05-01

    This paper describes the method using Microsoft Excel (Microsoft Corporation One Microsoft Way Redmond, WA 98052-6399) to compute the 5% overall site X/Q value and the 95th percentile of the distribution of doses to the nearest maximally exposed offsite individual (MEOI) in accordance with guidance from DOE-STD-3009-1994 and U.S. NRC Regulatory Guide 1.145-1982. The accurate determination of the 5% overall site X/Q value is the most important factor in the computation of the 95th percentile of the distribution of doses to the nearest MEOI. This method should be used to validate software codes that compute the X/Q. The 95th percentile of the distribution of doses to the nearest MEOI must be compared to the U.S. DOE Evaluation Guide of 25 rem to determine the relative severity of hazard to the public from a postulated, unmitigated design basis accident that involves an offsite release of radioactive material.

  10. Ubiad1 Is an Antioxidant Enzyme that Regulates eNOS Activity by CoQ10 Synthesis

    PubMed Central

    Mugoni, Vera; Postel, Ruben; Catanzaro, Valeria; De Luca, Elisa; Turco, Emilia; Digilio, Giuseppe; Silengo, Lorenzo; Murphy, Michael P.; Medana, Claudio; Stainier, Didier Y.R.; Bakkers, Jeroen; Santoro, Massimo M.

    2013-01-01

    Summary Protection against oxidative damage caused by excessive reactive oxygen species (ROS) by an antioxidant network is essential for the health of tissues, especially in the cardiovascular system. Here, we identified a gene with important antioxidant features by analyzing a null allele of zebrafish ubiad1, called barolo (bar). bar mutants show specific cardiovascular failure due to oxidative stress and ROS-mediated cellular damage. Human UBIAD1 is a nonmitochondrial prenyltransferase that synthesizes CoQ10 in the Golgi membrane compartment. Loss of UBIAD1 reduces the cytosolic pool of the antioxidant CoQ10 and leads to ROS-mediated lipid peroxidation in vascular cells. Surprisingly, inhibition of eNOS prevents Ubiad1-dependent cardiovascular oxidative damage, suggesting a crucial role for this enzyme and nonmitochondrial CoQ10 in NO signaling. These findings identify UBIAD1 as a nonmitochondrial CoQ10-forming enzyme with specific cardiovascular protective function via the modulation of eNOS activity. PMID:23374346

  11. JPRS Report, Science & Technology, Japan, MITI’s Large-Scale R&D Projects Reviewed

    DTIC Science & Technology

    1990-02-08

    pollutions, red tide, Active enzymes etc. for cleaners and detergents -- .... .... Intermediates aw materials for r rcosmetics and and medicines moisturizers...PN 00 1H carq 1 0 HZc4 IO -l~ to u .ci~’ *H 0 w 1 Q 0 r - 0 0J w H 04P 04- c0 a) 00 bD O44 0 w w 0 -p 00 021.J4 COQ )a > u0𔃺-0 T1 CL Cfp p P H -H14 OL

  12. Cultural Resources Literature Search and Records Review - Upper Mississippi River Basin. Volume 7. Pool 6.

    DTIC Science & Technology

    1983-01-01

    H 0- -1 . 0 - d U. 0- 4 X, i * ’w 7 E-4 rj U) r- c0 0 -4 P 4 H4 E-4 E 0- 4%D.10 0 -4 $4 )t% U4 ) H- to) 440 Ur- H- N -4-1 4--)4J 4 4-) U)iU $4 -.4 C...34I W,4. * 4-i W ) U z u L. U U En $-4 $4 -4 X M Z a)~ U4. ) 0 )c~ (a aUD ) La 0 -r - go)> 4l) Cl V U) M l W ’- V U) H-U) -4 35Cl ( P ’.44 0 $- Q ~- -H U...gr I E U C0 0C) t41-H. H- V U) 4.) En 0--4 10uVr LA I H- r- C3 U -4$k V C4J W :: - c Q)~ r. CN C3 r i-, 11 H - N n 04 004 4J E- 4 M 0 04 -4 UU) 94 0 p

  13. 27 CFR 19.634 - Computer-generated reports and transaction forms.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2013-04-01 2013-04-01 false Computer-generated reports... Reports Filing Forms and Reports § 19.634 Computer-generated reports and transaction forms. TTB will accept computer-generated reports of operations and transaction forms made using a computer printer on...

  14. 27 CFR 19.634 - Computer-generated reports and transaction forms.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2014-04-01 2014-04-01 false Computer-generated reports... Reports Filing Forms and Reports § 19.634 Computer-generated reports and transaction forms. TTB will accept computer-generated reports of operations and transaction forms made using a computer printer on...

  15. 27 CFR 19.634 - Computer-generated reports and transaction forms.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2012-04-01 2012-04-01 false Computer-generated reports... Reports Filing Forms and Reports § 19.634 Computer-generated reports and transaction forms. TTB will accept computer-generated reports of operations and transaction forms made using a computer printer on...

  16. 27 CFR 19.634 - Computer-generated reports and transaction forms.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Computer-generated reports... Reports Filing Forms and Reports § 19.634 Computer-generated reports and transaction forms. TTB will accept computer-generated reports of operations and transaction forms made using a computer printer on...

  17. Low-Dimensional Network Formation in Molten Sodium Carbonate

    PubMed Central

    Wilding, Martin C.; Wilson, Mark; Alderman, Oliver L. G.; Benmore, Chris; Weber, J. K. R.; Parise, John B.; Tamalonis, Anthony; Skinner, Lawrie

    2016-01-01

    Molten carbonates are highly inviscid liquids characterized by low melting points and high solubility of rare earth elements and volatile molecules. An understanding of the structure and related properties of these intriguing liquids has been limited to date. We report the results of a study of molten sodium carbonate (Na2CO3) which combines high energy X-ray diffraction, containerless techniques and computer simulation to provide insight into the liquid structure. Total structure factors (Fx(Q)) are collected on the laser-heated carbonate spheres suspended in flowing gases of varying composition in an aerodynamic levitation furnace. The respective partial structure factor contributions to Fx(Q) are obtained by performing molecular dynamics simulations treating the carbonate anions as flexible entities. The carbonate liquid structure is found to be heavily temperature-dependent. At low temperatures a low-dimensional carbonate chain network forms, at T = 1100 K for example ~55% of the C atoms form part of a chain. The mean chain lengths decrease as temperature is increased and as the chains become shorter the rotation of the carbonate anions becomes more rapid enhancing the diffusion of Na+ ions. PMID:27080401

  18. Phosphors for LED lamps

    DOEpatents

    Murphy, James Edward; Manepalli, Satya Kishore; Kumar, Prasanth Nammalwar

    2013-08-13

    A phosphor, a phosphor blend including the phosphor, a phosphor prepared by a process, and a lighting apparatus including the phosphor blend are disclosed. The phosphor has the formula (Ca.sub.1-p-qCe.sub.pK.sub.q).sub.xSc.sub.y(Si.sub.1-rGa.sub.r).sub.zO.su- b.12+.delta. or derived from a process followed using disclosed amounts of reactants. In the formula, (0

  19. 26 CFR 1.806-4 - Change of basis in computing reserves.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    .... For the taxable year 1959, S elects to revalue such reserves on a net level premium basis under... 26 Internal Revenue 8 2010-04-01 2010-04-01 false Change of basis in computing reserves. 1.806-4... TAX (CONTINUED) INCOME TAXES Investment Income § 1.806-4 Change of basis in computing reserves. (a) In...

  20. Composable Distributed Access Control and Integrity Policies for Query-Based Wireless Sensor Networks

    DTIC Science & Technology

    2008-03-01

    unaltered during transmission and verified with data authentication. Data Freshness describes the ordering and currency of data. Strong freshness is a total...Advances in Cryptology — Crypto ’97, volume 1294 of Lecture Notes in Computer Science, pages 180–197. Springer-Verlag, Berlin, 1997. GS04. Saurabh

  1. RTDS-Based Design and Simulation of Distributed P-Q Power Resources in Smart Grid

    NASA Astrophysics Data System (ADS)

    Taylor, Zachariah David

    In this Thesis, we propose to utilize a battery system together with its power electronics interfaces and bidirectional charger as a distributed P-Q resource in power distribution networks. First, we present an optimization-based approach to operate such distributed P-Q resources based on the characteristics of the battery and charger system as well as the features and needs of the power distribution network. Then, we use the RTDS Simulator, which is an industry-standard simulation tool of power systems, to develop two RTDS-based design approaches. The first design is based on an ideal four-quadrant distributed P-Q power resource. The second design is based on a detailed four-quadrant distributed P-Q power resource that is developed using power electronics components. The hardware and power electronics circuitry as well as the control units are explained for the second design. After that, given the two-RTDS designs, we conducted extensive RTDS simulations to assess the performance of the designed distributed P-Q Power Resource in an IEEE 13 bus test system. We observed that the proposed design can noticeably improve the operational performance of the power distribution grid in at least four key aspects: reducing power loss, active power peak load shaving at substation, reactive power peak load shaving at substation, and voltage regulation. We examine these performance measures across three design cases: Case 1: There is no P-Q Power Resource available on the power distribution network. Case 2: The installed P-Q Power Resource only supports active power, i.e., it only utilizes its battery component. Case 3: The installed P-Q Power Resource supports both active and reactive power, i.e., it utilizes both its battery component and its power electronics charger component. In the end, we present insightful interpretations on the simulation results and suggest some future works.

  2. Investigation of the Effect of Low Level Maritime Haze on DMSP VHR and LF Imagery.

    DTIC Science & Technology

    1980-09-09

    LA S LO i-4 CNJ 0) r m~X LA3 crj (N > Co -i s- - -I CN r -~ 4J. 4-4 C) 4-) >1 Cl) 0H 9 -r-( Nl NV C 0 MN (1)0 r4 s-4 L 4-)4 Uv) Cu...be approximated as : 5-12 o 0 LA r40 oD (n rn N .4 .-4 0 C14.. LA Ln LA N- 0N 0C) LA 4 . l4-) r-. LA en C4 N . 049 0 1 E-4~ . (1 0 .t 0 ’p .r LA LA LA ...w CN C1 04 .00 C4.) r -4 O N~ ’. r - CA a ’.0 LA w m~ N1 Q4-1 Ř .4.4 Q) I- Q) in - r-4 O 4 1d𔃺 -4 0 0 4J *-0 0~

  3. Leading-order determination of the gluon polarisation from semi-inclusive deep inelastic scattering data

    NASA Astrophysics Data System (ADS)

    Adolph, C.; Aghasyan, M.; Akhunzyanov, R.; Alexeev, M. G.; Alexeev, G. D.; Amoroso, A.; Andrieux, V.; Anfimov, N. V.; Anosov, V.; Augustyniak, W.; Austregesilo, A.; Azevedo, C. D. R.; Badełek, B.; Balestra, F.; Barth, J.; Beck, R.; Bedfer, Y.; Bernhard, J.; Bicker, K.; Bielert, E. R.; Birsa, R.; Bisplinghoff, J.; Bodlak, M.; Boer, M.; Bordalo, P.; Bradamante, F.; Braun, C.; Bressan, A.; Büchele, M.; Chang, W.-C.; Chiosso, M.; Choi, I.; Chung, S.-U.; Cicuttin, A.; Crespo, M. L.; Curiel, Q.; Dalla Torre, S.; Dasgupta, S. S.; Dasgupta, S.; Denisov, O. Yu.; Dhara, L.; Donskov, S. V.; Doshita, N.; Duic, V.; Dünnweber, W.; Dziewiecki, M.; Efremov, A.; Eversheim, P. D.; Eyrich, W.; Faessler, M.; Ferrero, A.; Finger, M.; , M. Finger, Jr.; Fischer, H.; Franco, C.; du Fresne von Hohenesche, N.; Friedrich, J. M.; Frolov, V.; Fuchey, E.; Gautheron, F.; Gavrichtchouk, O. P.; Gerassimov, S.; Giordano, F.; Gnesi, I.; Gorzellik, M.; Grabmüller, S.; Grasso, A.; Grosse Perdekamp, M.; Grube, B.; Grussenmeyer, T.; Guskov, A.; Haas, F.; Hahne, D.; von Harrach, D.; Hashimoto, R.; Heinsius, F. H.; Heitz, R.; Herrmann, F.; Hinterberger, F.; Horikawa, N.; d'Hose, N.; Hsieh, C.-Y.; Huber, S.; Ishimoto, S.; Ivanov, A.; Ivanshin, Yu.; Iwata, T.; Jahn, R.; Jary, V.; Joosten, R.; Jörg, P.; Kabuß, E.; Ketzer, B.; Khaustov, G. V.; Khokhlov, Yu. A.; Kisselev, Yu.; Klein, F.; Klimaszewski, K.; Koivuniemi, J. H.; Kolosov, V. N.; Kondo, K.; Königsmann, K.; Konorov, I.; Konstantinov, V. F.; Kotzinian, A. M.; Kouznetsov, O. M.; Krämer, M.; Kremser, P.; Krinner, F.; Kroumchtein, Z. V.; Kulinich, Y.; Kunne, F.; Kurek, K.; Kurjata, R. P.; Lednev, A. A.; Lehmann, A.; Levillain, M.; Levorato, S.; Lichtenstadt, J.; Longo, R.; Maggiora, A.; Magnon, A.; Makins, N.; Makke, N.; Mallot, G. K.; Marchand, C.; Marianski, B.; Martin, A.; Marzec, J.; Matoušek, J.; Matsuda, H.; Matsuda, T.; Meshcheryakov, G. V.; Meyer, W.; Michigami, T.; Mikhailov, Yu. V.; Mikhasenko, M.; Miyachi, Y.; Montuenga, P.; Nagaytsev, A.; Nerling, F.; Neyret, D.; Nikolaenko, V. I.; Nový, J.; Nowak, W.-D.; Nukazuka, G.; Nunes, A. S.; Olshevsky, A. G.; Orlov, I.; Ostrick, M.; Panzieri, D.; Parsamyan, B.; Paul, S.; Peng, J.-C.; Pereira, F.; Pešek, M.; Peshekhonov, D. V.; Platchkov, S.; Pochodzalla, J.; Polyakov, V. A.; Pretz, J.; Quaresma, M.; Quintans, C.; Ramos, S.; Regali, C.; Reicherz, G.; Riedl, C.; Roskot, M.; Rossiyskaya, N. S.; Ryabchikov, D. I.; Rybnikov, A.; Rychter, A.; Salac, R.; Samoylenko, V. D.; Sandacz, A.; Santos, C.; Sarkar, S.; Savin, I. A.; Sawada, T.; Sbrizzai, G.; Schiavon, P.; Schmidt, K.; Schmieden, H.; Schönning, K.; Schopferer, S.; Seder, E.; Selyunin, A.; Shevchenko, O. Yu.; Silva, L.; Sinha, L.; Sirtl, S.; Slunecka, M.; Smolik, J.; Sozzi, F.; Srnka, A.; Stolarski, M.; Sulc, M.; Suzuki, H.; Szabelski, A.; Szameitat, T.; Sznajder, P.; Takekawa, S.; Tasevsky, M.; Tessaro, S.; Tessarotto, F.; Thibaud, F.; Tosello, F.; Tskhay, V.; Uhl, S.; Veloso, J.; Virius, M.; Vondra, J.; Weisrock, T.; Wilfert, M.; ter Wolbeek, J.; Zaremba, K.; Zavada, P.; Zavertyaev, M.; Zemlyanichkina, E.; Ziembicki, M.; Zink, A.

    2017-04-01

    Using a novel analysis technique, the gluon polarisation in the nucleon is re-evaluated using the longitudinal double-spin asymmetry measured in the cross section of semi-inclusive single-hadron muoproduction with photon virtuality Q^2>1 (GeV/c)^2. The data were obtained by the COMPASS experiment at CERN using a 160 GeV/ c polarised muon beam impinging on a polarised ^6LiD target. By analysing the full range in hadron transverse momentum p_T, the different p_T-dependences of the underlying processes are separated using a neural-network approach. In the absence of pQCD calculations at next-to-leading order in the selected kinematic domain, the gluon polarisation Δ g/g is evaluated at leading order in pQCD at a hard scale of μ ^2= < Q^2 \\rangle = 3 (GeV/c)^2. It is determined in three intervals of the nucleon momentum fraction carried by gluons, x_g, covering the range 0.04 < x_{g} < 0.28 and does not exhibit a significant dependence on x_g. The average over the three intervals, < Δ g/g \\rangle = 0.113 ± 0.038_(stat.)± 0.036_(syst.) at < x_g \\rangle ≈ 0.10, suggests that the gluon polarisation is positive in the measured x_g range.

  4. Numerical Experiments on Advective Transport in Large Three-Dimensional Discrete Fracture Networks

    NASA Astrophysics Data System (ADS)

    Makedonska, N.; Painter, S. L.; Karra, S.; Gable, C. W.

    2013-12-01

    Modeling of flow and solute transport in discrete fracture networks is an important approach for understanding the migration of contaminants in impermeable hard rocks such as granite, where fractures provide dominant flow and transport pathways. The discrete fracture network (DFN) model attempts to mimic discrete pathways for fluid flow through a fractured low-permeable rock mass, and may be combined with particle tracking simulations to address solute transport. However, experience has shown that it is challenging to obtain accurate transport results in three-dimensional DFNs because of the high computational burden and difficulty in constructing a high-quality unstructured computational mesh on simulated fractures. An integrated DFN meshing [1], flow, and particle tracking [2] simulation capability that enables accurate flow and particle tracking simulation on large DFNs has recently been developed. The new capability has been used in numerical experiments on advective transport in large DFNs with tens of thousands of fractures and millions of computational cells. The modeling procedure starts from the fracture network generation using a stochastic model derived from site data. A high-quality computational mesh is then generated [1]. Flow is then solved using the highly parallel PFLOTRAN [3] code. PFLOTRAN uses the finite volume approach, which is locally mass conserving and thus eliminates mass balance problems during particle tracking. The flow solver provides the scalar fluxes on each control volume face. From the obtained fluxes the Darcy velocity is reconstructed for each node in the network [4]. Velocities can then be continuously interpolated to any point in the domain of interest, thus enabling random walk particle tracking. In order to describe the flow field on fractures intersections, the control volume cells on intersections are split into four planar polygons, where each polygon corresponds to a piece of a fracture near the intersection line. Thus, computational nodes lying on fracture intersections have four associated velocities, one on each side of the intersection in each fracture plane [2]. This information is used to route particles arriving at the fracture intersection to the appropriate downstream fracture segment. Verified for small DFNs, the new simulation capability allows accurate particle tracking on more realistic representations of fractured rock sites. In the current work we focus on travel time statistics and spatial dispersion and show numerical results in DFNs of different sizes, fracture densities, and transmissivity distributions. [1] Hyman J.D., Gable C.W., Painter S.L., Automated meshing of stochastically generated discrete fracture networks, Abstract H33G-1403, 2011 AGU, San Francisco, CA, 5-9 Dec. [2] N. Makedonska, S. L. Painter, T.-L. Hsieh, Q.M. Bui, and C. W. Gable., Development and verification of a new particle tracking capability for modeling radionuclide transport in discrete fracture networks, Abstract, 2013 IHLRWM, Albuquerque, NM, Apr. 28 - May 3. [3] Lichtner, P.C., Hammond, G.E., Bisht, G., Karra, S., Mills, R.T., and Kumar, J. (2013) PFLOTRAN User's Manual: A Massively Parallel Reactive Flow Code. [4] Painter S.L., Gable C.W., Kelkar S., Pathline tracing on fully unstructured control-volume grids, Computational Geosciences, 16 (4), 2012, 1125-1134.

  5. SCNS: a graphical tool for reconstructing executable regulatory networks from single-cell genomic data.

    PubMed

    Woodhouse, Steven; Piterman, Nir; Wintersteiger, Christoph M; Göttgens, Berthold; Fisher, Jasmin

    2018-05-25

    Reconstruction of executable mechanistic models from single-cell gene expression data represents a powerful approach to understanding developmental and disease processes. New ambitious efforts like the Human Cell Atlas will soon lead to an explosion of data with potential for uncovering and understanding the regulatory networks which underlie the behaviour of all human cells. In order to take advantage of this data, however, there is a need for general-purpose, user-friendly and efficient computational tools that can be readily used by biologists who do not have specialist computer science knowledge. The Single Cell Network Synthesis toolkit (SCNS) is a general-purpose computational tool for the reconstruction and analysis of executable models from single-cell gene expression data. Through a graphical user interface, SCNS takes single-cell qPCR or RNA-sequencing data taken across a time course, and searches for logical rules that drive transitions from early cell states towards late cell states. Because the resulting reconstructed models are executable, they can be used to make predictions about the effect of specific gene perturbations on the generation of specific lineages. SCNS should be of broad interest to the growing number of researchers working in single-cell genomics and will help further facilitate the generation of valuable mechanistic insights into developmental, homeostatic and disease processes.

  6. 17 CFR 1.32 - Segregated account; daily computation and record.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 1 2011-04-01 2011-04-01 false Segregated account; daily computation and record. 1.32 Section 1.32 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION GENERAL REGULATIONS UNDER THE COMMODITY EXCHANGE ACT Recordkeeping § 1.32 Segregated account...

  7. The Importance of Slag Structure to Boron Removal from Silicon during the Refining Process: Insights from Raman and Nuclear Magnetic Resonance Spectroscopy Study

    NASA Astrophysics Data System (ADS)

    Qian, Guoyu; Wang, Zhi; Gong, Xuzhong; Sun, Liyuan

    2017-12-01

    Slag structure plays an important role in determining the relative ease of boron removal from silicon. Correlation between slag structure and boron removal thermodynamics was experimentally studied by Raman and nuclear magnetic resonance (NMR) spectroscopy using CaO-SiO2-Na2O slags with different optical basicities (0.6 to 0.71). Optimization of slag depolymerization leads to efficient removal of boron. The extent of nonbridged oxygen content (NBO/T) and boron removal gradually increased with an increase in optical basicity from 0.6 to 0.66: B2O3 derived from boron oxidation captured nonbridging oxygens of Q 0(Si), Q 1(Si), and Q 2(Si), and was incorporated into the silicate network in the form of Q 3(Si and B). When optical basicity increased to 0.71, NBO/T rapidly increased and boron removal decreased considerably. Quick depolymerization of Q 3(Si and B) deteriorated the stability of boron. Various structural forms of boron in the silicate network were successfully detected: the BO3 trihedrons [3]B-3Si, [3]B-2Si-1NBO, and BO3 (nonring), and the BO4 tetrahedrons BO4 (1B, 3Si) and BO4 (0B, 4Si). BO4 (1B, 3Si) was the main structure contributing to the increase of boron capacity; BO3 (nonring), detected under higher optical basicity conditions, may cause deterioration of boron removal by suppressing its oxidation.

  8. Estimation of the intrinsic absorption and scattering attenuation in Northeastern Venezuela (Southeastern Caribbean) using coda waves

    USGS Publications Warehouse

    Ugalde, A.; Pujades, L.G.; Canas, J.A.; Villasenor, A.

    1998-01-01

    Northeastern Venezuela has been studied in terms of coda wave attenuation using seismograms from local earthquakes recorded by a temporary short-period seismic network. The studied area has been separated into two subregions in order to investigate lateral variations in the attenuation parameters. Coda-Q-1 (Q(c)-1) has been obtained using the single-scattering theory. The contribution of the intrinsic absorption (Q(i)-1) and scattering (Q(s)-1) to total attenuation (Q(t)-1) has been estimated by means of a multiple lapse time window method, based on the hypothesis of multiple isotropic scattering with uniform distribution of scatterers. Results show significant spatial variations of attenuation: the estimates for intermediate depth events and for shallow events present major differences. This fact may be related to different tectonic characteristics that may be due to the presence of the Lesser Antilles subduction zone, because the intermediate depth seismic zone may be coincident with the southern continuation of the subducting slab under the arc.

  9. Gas-phase structural characterization of neuropeptides Y Y1 receptor antagonists using mass spectrometry: Orbitrap vs triple quadrupole.

    PubMed

    Silva, Eduarda M P; Varandas, Pedro A M M; Melo, Tânia; Barros, Cristina; Alencastre, Inês S; Barreiros, Luísa; Domingues, Pedro; Lamghari, Meriem; Domingues, M Rosário M; Segundo, Marcela A

    2018-03-20

    Collision induced dissociation of triple quadrupole mass spectrometer (CID-QqQ) and high-energy collision dissociation (HCD) of Orbitrap were compared for four neuropeptides Y Y1 (NPY Y1) receptor antagonists and showed similar qualitative fragmentation and structural information. Orbitrap high resolution and high mass accuracy HCD fragmentation spectra allowed unambiguous identification of product ions in the range 0.04-4.25 ppm. Orbitrap mass spectrometry showed abundant analyte-specific product ions also observed on CID-QqQ. These results show the suitability of these product ions for use in quantitative analysis by MRM mode. In addition, it was found that all compounds could be determined at levels >1 μg L -1 using the QqQ instrument and that the detection limits for this analyzer ranged from 0.02 to 0.6 μg L -1 . Overall, the results obtained from experiments acquired in QqQ show a good agreement with those acquired from the Orbitrap instrument allowing the use of this relatively inexpensive technique (QqQ) for accurate quantification of these compounds in clinical and academic applications. Copyright © 2018 Elsevier B.V. All rights reserved.

  10. Influence of pulmonary factors on pulse oximeter saturation in preterm infants.

    PubMed

    Jones, J G; Lockwood, G G; Fung, N; Lasenby, J; Ross-Russell, R I; Quine, D; Stenson, B J

    2016-07-01

    To describe how the stability of oxygen saturation measured by pulse oximetry (SpO2%) varies within and between infants with bronchopulmonary dysplasia (BPD). Clinically stable infants with BPD had SpO2 measured at different inspired oxygen concentrations (FIO2 expressed as %). A computer model of gas exchange, that is, ventilation/perfusion ratio (VA/Q) and shunt, plotted the curve of SpO2 versus FIO2 best fitting these data. The slope of this curve is the change in SpO2 per % change in FIO2, hence SpO2 stability, calculated at each SpO2 from 85% to 95%. Data from 16 infants with BPD previously described were analysed. The dominant gas exchange impairment was low VA/Q (median 0.35, IQR, 0.16-0.4, normal 0.86). Median shunt was 1% (IQR, 0-10.5; normal <2%). Slope varied markedly between infants, but above 95% SpO2 was always <1.5. In infants with least severe BPD (VA/Q ≈0.4, shunt ≤2%) median slope at 85% SpO2 was 5.1 (IQR, 3.7-5.5). With more severe BPD (VA/Q ≤0.3) slope was flatter throughout the SpO2 range. The highest FIO2 for 90% SpO2 was in infants with the lowest VA/Q values. In infants with BPD, there was large variation in the slope of the curve relating SpO2% to inspired oxygen fraction in the SpO2 range 85%-95%. Slopes were considerably steeper at lower than higher SpO2, especially in infants with least severe BPD, meaning that higher SpO2 target values are intrinsically much more stable. Steep slopes below 90% SpO2 may explain why some infants appear dependent on remarkably low oxygen flows. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  11. Prime Contract Awards by FSC/SVC and Purchasing Office in Excess of $100,000. FY 1992 (1005 Guns thru 30 mm -- 8130 Reels and Spools)

    DTIC Science & Technology

    1993-01-01

    gn -*( 0Q 0 00 N 40 a a:wo to00)0 . C4 L~.4 U.U.L f6 - 1 -l 00o.00 4 Cfl4 mlC4 P. q w-i N4 r- Z-i (A N f 6-0 -IIn 4c (A (fl i N r- -I .4 C4 w-4 (no 00...V40& X U -- C -- 0. - =: z 0.V 4L CLO U U .4 .4U isQ3t lb 4. Cl . c൰VLSC io&C -4 CL > . 0O ACCa I.- (A-1.. S4 It ;: 0 0 04 06 > t I .. C ..4 0 o 1

  12. 20 CFR 226.62 - Computing average monthly compensation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Computing average monthly compensation. 226... RETIREMENT ACT COMPUTING EMPLOYEE, SPOUSE, AND DIVORCED SPOUSE ANNUITIES Years of Service and Average Monthly Compensation § 226.62 Computing average monthly compensation. The employee's average monthly compensation is...

  13. Model based verification of the Secure Socket Layer (SSL) Protocol for NASA systems

    NASA Technical Reports Server (NTRS)

    Powell, John D.; Gilliam, David

    2004-01-01

    The National Aeronautics and Space Administration (NASA) has tens of thousands of networked computer systems and applications. Software Security vulnerabilities present risks such as lost or corrupted data, information theft, and unavailability of critical systems. These risks represent potentially enormous costs to NASA. The NASA Code Q research initiative 'Reducing Software Security Risk (RSSR) Trough an Integrated Approach' offers formal verification of information technology (IT), through the creation of a Software Security Assessment Instrument (SSAI), to address software security risks.

  14. Spontaneous repulsion in the A +B →0 reaction on coupled networks

    NASA Astrophysics Data System (ADS)

    Lazaridis, Filippos; Gross, Bnaya; Maragakis, Michael; Argyrakis, Panos; Bonamassa, Ivan; Havlin, Shlomo; Cohen, Reuven

    2018-04-01

    We study the transient dynamics of an A +B →0 process on a pair of randomly coupled networks, where reactants are initially separated. We find that, for sufficiently small fractions q of cross couplings, the concentration of A (or B ) particles decays linearly in a first stage and crosses over to a second linear decrease at a mixing time tx. By numerical and analytical arguments, we show that for symmetric and homogeneous structures tx∝(/q)log(/q) where is the mean degree of both networks. Being this behavior is in marked contrast with a purely diffusive process, where the mixing time would go simply like /q , we identify the logarithmic slowing down in tx to be the result of a spontaneous mechanism of repulsion between the reactants A and B due to the interactions taking place at the networks' interface. We show numerically how this spontaneous repulsion effect depends on the topology of the underlying networks.

  15. P06.19 TERT promoter mutation is an independent prognostic factor in 1p/19q co-deleted oligodendrogliomas: a POLA network study

    PubMed Central

    Alentorn, A.; Carpentier, C.; Labreche, K.; Ducray, F.; Dehais, C.; Mokhtari, K.; Uro-Coste, E.; Figarella-Branger, D.; Delattre, J.; Idbaih, A.

    2016-01-01

    Abstract Background: Overall, gliomas harboring 1p19q co-deletion (oligodendrogliomas in the future WHO classification) have better prognosis and better response to treatments compared to their non 1p/19q co-deleted counterparts. However, some of these tumors have disconcerting poor outcome. We have recently shown that chromosome arm 9p loss of heterozygosity (9pLOH) participates to identify some but not all oligodendrogliomas with an aggressive clinical behavior. In parallel, TERT promoter (TERTp) mutations have been recently described as the most frequent mutations in oligodendrogliomas. Objectives: We sought to study the potential clinical significance of TERTp mutational status in oligodendrogliomas. Material and methods: 224 anaplastic oligodendrogliomas (AO) from the POLA network, were included in the present study. TERT mutational status was obtained using Sanger sequencing and SNP-array. 121 lower grade gliomas exhibiting 1p/19q co-deletion, from the TCGA dataset, were used as the validation cohort. In this latter series, level of TERT expression, obtained by RNA-sequencing, was used as a surrogate marker of TERTp mutation. 1p/19q co-deletion was defined as loss of whole-chromosome arms 1p and 19q using allelic-specific copy number analysis. Overall survivals (OS) were compared using log-rank test in univariate analysis. All covariates with p-value < 0.2 were included in a Cox’s proportional hazard ratio model for multivariate analysis. Statistical tests were two-sided and p-values < 0.05 were interpreted as statistically significant. Results: TERTp was wild-type (wt) in 14/224 AO (6.25%) in POLA cohort and in 8/121 (6.6%) in TCGA dataset. TERTp wt is associated with poor OS in univariate analysis in POLA and TCGA cohorts (p=0.032 and p=0.035, respectively). Interestingly, after adjusting for allelic 9p LOH, age (<50 vs. ≥ 50 years), treatment (chemotherapy and radiotherapy versus other treatments) and WHO grade (II vs III), TERTp mutation was an independent favorable prognostic factor in the POLA cohort (p=0.037, HR=3.7 (1.1–13)) and in the TCGA dataset (p=0.01, HR=9.8 (1.6–60)). Conclusion: This study identifies TERTp mutation as a novel independent prognostic biomarker in oligodendrogliomas toward a better stratification of this tumor type. Acknowledgements: The results shown here are in whole or part based upon data generated by the TCGA Research Network: http://cancergenome.nih.gov/. La Ligue Nationale Contre La Cancer. The Institut Universitaire de Cancérologie (IUC). The program Investissements d’avenir” ANR-10-IAIHU-06. POLA network is supported by Institut National du Cancer.

  16. Search for heavy vector-like quarks coupling to light quarks in proton–proton collisions at s = 7   TeV with the ATLAS detector

    DOE PAGES

    Aad, G.; Abbott, B.; Abdallah, J.; ...

    2012-05-01

    This Letter presents a search for singly produced vector-like quarks, Q, coupling to light quarks, q. The search is sensitive to both charged current (CC) and neutral current (NC) processes, pp→Qq→Wqq' and pp→Qq→Zqq' with a leptonic decay of the vector gauge boson. In 1.04fb -1 of data taken in 2011 by the ATLAS experiment at a center-of-mass energy √s=7TeV, no evidence of such heavy vector-like quarks is observed above the expected Standard Model background. Limits on the heavy vector-like quark production cross section times branching ratio as a function of mass m Q are obtained. For a coupling κ qQ=v/mmore » Q, where v is the Higgs vacuum expectation value, 95% C.L. lower limits on the mass of a vector-like quark are set at 900 GeV and 760 GeV from CC and NC processes, respectively.« less

  17. Characterizing differences in mortality at the low end of the fitness spectrum in individuals with cardiovascular disease.

    PubMed

    Mandic, Sandra; Myers, Jonathan; Oliveira, Ricardo B; Abella, Joshua; Froelicher, Victor F

    2010-06-01

    A graded but nonlinear relationship exists between fitness and mortality, with the greatest mortality differences occurring between the least-fit (first, Q1) and the next-least-fit (second, Q2) quintiles of fitness. The purpose of this study was to compare clinical characteristics, exercise test responses, and physical activity (PA) patterns in Q1 versus Q2 in patients with cardiovascular disease (CVD). Observational retrospective study. A total of 5101 patients with a history of CVD underwent clinical treadmill testing and were followed up for 9.1+/-5.5 years. Patients were classified into quintiles of exercise capacity measured in metabolic equivalents. Clinical characteristics, treadmill test results, and recreational PA patterns were compared between Q1 (n = 923) and Q2 (n = 929). Q1 had a nearly two-fold increase in age-adjusted relative risk of cardiovascular mortality compared with Q2 (hazard ratio: 3.79 vs. 2.04, P<0.05; reference: fittest quintile). Q1 patients were older, had more extensive use of medications, and were more likely to have a history of typical angina (35 vs. 28%), myocardial infarction (30 vs. 24%), chronic heart failure (25 vs. 14%), claudication (15 vs. 9%) and stroke (9 vs. 6%) compared with Q2 (all comparisons: P<0.05). Recent and lifetime recreational PA was not different between the two groups. Greater severity of disease in the least-fit versus the next-least-fit quintile likely contributes to but cannot fully explain marked differences in mortality rates in CVD patients. To achieve potential survival benefits, our results suggest that unfit CVD patients should engage in exercise programs of sufficient volume and intensity to improve fitness.

  18. Quasicrystals and Quantum Computing

    NASA Astrophysics Data System (ADS)

    Berezin, Alexander A.

    1997-03-01

    In Quantum (Q) Computing qubits form Q-superpositions for macroscopic times. One scheme for ultra-fast (Q) computing can be based on quasicrystals. Ultrafast processing in Q-coherent structures (and the very existence of durable Q-superpositions) may be 'consequence' of presence of entire manifold of integer arithmetic (A0, aleph-naught of Georg Cantor) at any 4-point of space-time, furthermore, at any point of any multidimensional phase space of (any) N-particle Q-system. The latter, apart from quasicrystals, can include dispersed and/or diluted systems (Berezin, 1994). In such systems such alleged centrepieces of Q-Computing as ability for fast factorization of long integers can be processed by sheer virtue of the fact that entire infinite pattern of prime numbers is instantaneously available as 'free lunch' at any instant/point. Infinitely rich pattern of A0 (including pattern of primes and almost primes) acts as 'independent' physical effect which directly generates Q-dynamics (and physical world) 'out of nothing'. Thus Q-nonlocality can be ultimately based on instantaneous interconnectedness through ever- the-same structure of A0 ('Platonic field' of integers).

  19. Direct lifts of coupled cell networks

    NASA Astrophysics Data System (ADS)

    Dias, A. P. S.; Moreira, C. S.

    2018-04-01

    In networks of dynamical systems, there are spaces defined in terms of equalities of cell coordinates which are flow-invariant under any dynamical system that has a form consistent with the given underlying network structure—the network synchrony subspaces. Given a network and one of its synchrony subspaces, any system with a form consistent with the network, restricted to the synchrony subspace, defines a new system which is consistent with a smaller network, called the quotient network of the original network by the synchrony subspace. Moreover, any system associated with the quotient can be interpreted as the restriction to the synchrony subspace of a system associated with the original network. We call the larger network a lift of the smaller network, and a lift can be interpreted as a result of the cellular splitting of the smaller network. In this paper, we address the question of the uniqueness in this lifting process in terms of the networks’ topologies. A lift G of a given network Q is said to be direct when there are no intermediate lifts of Q between them. We provide necessary and sufficient conditions for a lift of a general network to be direct. Our results characterize direct lifts using the subnetworks of all splitting cells of Q and of all split cells of G. We show that G is a direct lift of Q if and only if either the split subnetwork is a direct lift or consists of two copies of the splitting subnetwork. These results are then applied to the class of regular uniform networks and to the special classes of ring networks and acyclic networks. We also illustrate that one of the applications of our results is to the lifting bifurcation problem.

  20. Impact of short-term preconceptional exposure to particulate air pollution on treatment outcome in couples undergoing in vitro fertilization and embryo transfer (IVF/ET)

    PubMed Central

    Maluf, Mariangela; Czeresnia, Carlos Eduardo; Januário, Daniela Aparecida Nicolosi Foltran; Saldiva, Paulo Hilário Nascimento

    2010-01-01

    Purpose To assess the potential effects of short-term exposure to particulate air pollution during follicular phase on clinical, laboratory, and pregnancy outcomes of women undergoing IVF/ET. Methods Retrospective cohort study of 400 first IVF/ET cycles of women exposed to ambient particulate matter during follicular phase. Particulate matter (PM) was categorized into quartiles (Q1: ≤30.48 µg/m3, Q2: 30.49–42.00 µg/m3, Q3: 42.01–56.72 µg/m3, and Q4: >56.72 µg/m3). Results Clinical, laboratory, or treatment variables were not affected by follicular phase PM exposure periods. Women exposed to Q4 period during the follicular phase of conception cycles had a higher risk of miscarriage (odds ratio, 5.05; 95% confidence interval: 1.04–25.51) when compared to women exposed to Q1–3 periods. Conclusion Our results show an association between brief exposure to high levels of ambient PM during the preconceptional period and early pregnancy loss, although no effect of this exposure on clinical, laboratory, and treatment outcomes was observed. PMID:20405197

  1. Plasma zinc in institutionalized elderly individuals: Relation with immune and cardiometabolic biomarkers.

    PubMed

    Sales, Márcia Cristina; de Oliveira, Larissa Praça; de Araújo Cabral, Natalia Louise; de Sousa, Sara Estéfani Soares; das Graças Almeida, Maria; Lemos, Telma Maria Araújo Moura; de Oliveira Lyra, Clélia; de Lima, Kenio Costa; Sena-Evangelista, Karine Cavalcanti Mauricio; de Fatima Campos Pedrosa, Lucia

    2018-04-24

    Changes in zinc metabolism caused by aging and the institutionalization process may contribute to zinc deficiency in elderly individuals. Hypozincemia results in changes in glycemic, lipid, and inflammatory profiles. The aim of this study was to evaluate plasma zinc concentrations and their relationships with sociodemographic, dietary, inflammatory, and cardiometabolic biomarkers in institutionalized elderly individuals. A cross-sectional study was carried out including 255 elderly adults living in nursing homes. The associations between plasma zinc and dietary zinc intake, sociodemographic indicators, and glycemic, lipid, and inflammatory biomarkers were evaluated. Independent variables were analyzed according to quartiles of plasma zinc concentrations (Q1: <71.1 μg/dL; Q2: 71.1-83.3 μg/dL; Q3: <83.3-93.7 μg/dL; Q4: >93.7 μg/dL). The relationship between plasma zinc concentrations and predictor variables was also tested. In Q1, higher concentrations of the following variables were observed, compared with those in other quartiles: total cholesterol and low-density lipoprotein cholesterol (LDL-c; Q1 > Q2, Q3, Q4; all p <0.001); triglycerides (Q1 > Q3, Q4; all p < 0.001); interleukin (IL)-6 (Q1 > Q3, Q4; p = 0.024 and p = 0.010, respectively); tumor necrosis factor (TNF)-α (Q1 > Q3, p = 0.003). A significant reduction in plasma zinc concentrations was observed with increasing age-adjusted institutionalization time (Δ = - 0.10; 95% confidence interval [CI]: -0.18 to -0.01). The concentrations of total cholesterol (Δ = - 0.19; 95% CI: -0.23 to -0.15), LDL-c (Δ = - 0.19; 95% CI: -0.23 to -0.15), triglycerides (Δ = - 0.11; 95% CI: -0.16 to -0.06), IL-6 (Δ = - 1.41; 95% CI: -2.64 to -0.18), and TNF-α (Δ = - 1.04; 95% CI: -1.71 to -0.36) were also significantly increased. In conclusion, decreased plasma zinc concentrations were associated with longer institutionalization time and worse lipid and inflammatory profiles in elderly institutionalized individuals. Published by Elsevier GmbH.

  2. Potential of European 14CO2 observation network to estimate the fossil fuel CO2 emissions via atmospheric inversions

    NASA Astrophysics Data System (ADS)

    Wang, Yilong; Broquet, Grégoire; Ciais, Philippe; Chevallier, Frédéric; Vogel, Felix; Wu, Lin; Yin, Yi; Wang, Rong; Tao, Shu

    2018-03-01

    Combining measurements of atmospheric CO2 and its radiocarbon (14CO2) fraction and transport modeling in atmospheric inversions offers a way to derive improved estimates of CO2 emitted from fossil fuel (FFCO2). In this study, we solve for the monthly FFCO2 emission budgets at regional scale (i.e., the size of a medium-sized country in Europe) and investigate the performance of different observation networks and sampling strategies across Europe. The inversion system is built on the LMDZv4 global transport model at 3.75° × 2.5° resolution. We conduct Observing System Simulation Experiments (OSSEs) and use two types of diagnostics to assess the potential of the observation and inverse modeling frameworks. The first one relies on the theoretical computation of the uncertainty in the estimate of emissions from the inversion, known as posterior uncertainty, and on the uncertainty reduction compared to the uncertainty in the inventories of these emissions, which are used as a prior knowledge by the inversion (called prior uncertainty). The second one is based on comparisons of prior and posterior estimates of the emission to synthetic true emissions when these true emissions are used beforehand to generate the synthetic fossil fuel CO2 mixing ratio measurements that are assimilated in the inversion. With 17 stations currently measuring 14CO2 across Europe using 2-week integrated sampling, the uncertainty reduction for monthly FFCO2 emissions in a country where the network is rather dense like Germany, is larger than 30 %. With the 43 14CO2 measurement stations planned in Europe, the uncertainty reduction for monthly FFCO2 emissions is increased for the UK, France, Italy, eastern Europe and the Balkans, depending on the configuration of prior uncertainty. Further increasing the number of stations or the sampling frequency improves the uncertainty reduction (up to 40 to 70 %) in high emitting regions, but the performance of the inversion remains limited over low-emitting regions, even assuming a dense observation network covering the whole of Europe. This study also shows that both the theoretical uncertainty reduction (and resulting posterior uncertainty) from the inversion and the posterior estimate of emissions itself, for a given prior and true estimate of the emissions, are highly sensitive to the choice between two configurations of the prior uncertainty derived from the general estimate by inventory compilers or computations on existing inventories. In particular, when the configuration of the prior uncertainty statistics in the inversion system does not match the difference between these prior and true estimates, the posterior estimate of emissions deviates significantly from the truth. This highlights the difficulty of filtering the targeted signal in the model-data misfit for this specific inversion framework, the need to strongly rely on the prior uncertainty characterization for this and, consequently, the need for improved estimates of the uncertainties in current emission inventories for real applications with actual data. We apply the posterior uncertainty in annual emissions to the problem of detecting a trend of FFCO2, showing that increasing the monitoring period (e.g., more than 20 years) is more efficient than reducing uncertainty in annual emissions by adding stations. The coarse spatial resolution of the atmospheric transport model used in this OSSE (typical of models used for global inversions of natural CO2 fluxes) leads to large representation errors (related to the inability of the transport model to capture the spatial variability of the actual fluxes and mixing ratios at subgrid scales), which is a key limitation of our OSSE setup to improve the accuracy of the monitoring of FFCO2 emissions in European regions. Using a high-resolution transport model should improve the potential to retrieve FFCO2 emissions, and this needs to be investigated.

  3. Vector and Axial Form Factors Applied to Neutrino Quasielastic Scattering

    NASA Astrophysics Data System (ADS)

    Budd, H.; Bodek, A.; Arrington, J.

    2005-02-01

    We calculate the quasielastic cross sections for neutrino scattering on nucleons using up to date fits to the nucleon elastic electromagnetic form factors GEp, GEn, GMp, GMn, and weak form factors. We show the extraction of F(q). We show the that F(q) has a different contribution to the anti-neutrino cross section, and how the anti-neutrino data can be used to check F(q) extracted from neutrino scattering. (Presented by Howard Budd at NuInt04, Mar. 2004, Laboratori Nazionali del Gran Sasso - INFN - Assergi, Italy [ http://nuint04.lngs.infn.it/])

  4. Resting-state Network-specific Breakdown of Functional Connectivity during Ketamine Alteration of Consciousness in Volunteers.

    PubMed

    Bonhomme, Vincent; Vanhaudenhuyse, Audrey; Demertzi, Athena; Bruno, Marie-Aurélie; Jaquet, Oceane; Bahri, Mohamed Ali; Plenevaux, Alain; Boly, Melanie; Boveroux, Pierre; Soddu, Andrea; Brichant, Jean François; Maquet, Pierre; Laureys, Steven

    2016-11-01

    Consciousness-altering anesthetic agents disturb connectivity between brain regions composing the resting-state consciousness networks (RSNs). The default mode network (DMn), executive control network, salience network (SALn), auditory network, sensorimotor network (SMn), and visual network sustain mentation. Ketamine modifies consciousness differently from other agents, producing psychedelic dreaming and no apparent interaction with the environment. The authors used functional magnetic resonance imaging to explore ketamine-induced changes in RSNs connectivity. Fourteen healthy volunteers received stepwise intravenous infusions of ketamine up to loss of responsiveness. Because of agitation, data from six subjects were excluded from analysis. RSNs connectivity was compared between absence of ketamine (wake state [W1]), light ketamine sedation, and ketamine-induced unresponsiveness (deep sedation [S2]). Increasing the depth of ketamine sedation from W1 to S2 altered DMn and SALn connectivity and suppressed the anticorrelated activity between DMn and other brain regions. During S2, DMn connectivity, particularly between the medial prefrontal cortex and the remaining network (effect size β [95% CI]: W1 = 0.20 [0.18 to 0.22]; S2 = 0.07 [0.04 to 0.09]), and DMn anticorrelated activity (e.g., right sensory cortex: W1 = -0.07 [-0.09 to -0.04]; S2 = 0.04 [0.01 to 0.06]) were broken down. SALn connectivity was nonuniformly suppressed (e.g., left parietal operculum: W1 = 0.08 [0.06 to 0.09]; S2 = 0.05 [0.02 to 0.07]). Executive control networks, auditory network, SMn, and visual network were minimally affected. Ketamine induces specific changes in connectivity within and between RSNs. Breakdown of frontoparietal DMn connectivity and DMn anticorrelation and sensory and SMn connectivity preservation are common to ketamine and propofol-induced alterations of consciousness.

  5. Characteristics of Low-q(a) Disruptions in the Compact Toroidal Hybrid

    NASA Astrophysics Data System (ADS)

    Pandya, M. D.; Archmiller, M. C.; Ennis, D. A.; Hartwell, G. J.; Maurer, D. A.

    2014-10-01

    Tokamak disruptions are dramatic events that lead to a sudden loss of plasma confinement. Disruptions that occur at low edge safety-factor, q (a) , limit the operation of tokamaks to q (a) >= 2 . The Compact Toroidal Hybrid (CTH) is a torsatron-tokamak hybrid with a helical field coil and vertical field coils to establish a stellartor equilibrium, while an ohmic coil induces plasma current. A feature of the CTH device is the ability to adjust the vacuum rotational transform, tvac (t =1/q ), by varying the ratio of current in the helical and toroidal field coils. The value of edge tvac can be varied from about 0.02 to 0.3 (qvac (a) ~ 50 to 3.3). Plasma discharges in CTH are routinely observed to operate with q (a) < 2 , and in some cases as low as q (a) ~ 1 . 1 . In CTH, low-q(a) disruptions are observed with a dominant m/n=3/2 precursor. The disruptivity of plasma discharges is over 80% when tvac (a) < 0 . 04 (qvac (a) < 25) and as tvac (a) is increased further, the disruptivity of the plasma discharges decreases. The disruptions are completely suppressed for tvac (a) > 0 . 07 (qvac (a) ~ 14) . This work is supported by US Department of Energy Grant No. DE-FG02-00ER54610.

  6. From atomic structure to excess entropy: a neutron diffraction and density functional theory study of CaO-Al2O3-SiO2 melts

    NASA Astrophysics Data System (ADS)

    Liu, Maoyuan; Jacob, Aurélie; Schmetterer, Clemens; Masset, Patrick J.; Hennet, Louis; Fischer, Henry E.; Kozaily, Jad; Jahn, Sandro; Gray-Weale, Angus

    2016-04-01

    Calcium aluminosilicate \\text{CaO}-\\text{A}{{\\text{l}}2}{{\\text{O}}3}-\\text{Si}{{\\text{O}}2} (CAS) melts with compositions {{≤ft(\\text{CaO}-\\text{Si}{{\\text{O}}2}\\right)}x}{{≤ft(\\text{A}{{\\text{l}}2}{{\\text{O}}3}\\right)}1-x} for x  <  0.5 and {{≤ft(\\text{A}{{\\text{l}}2}{{\\text{O}}3}\\right)}x}{{≤ft(\\text{Si}{{\\text{O}}2}\\right)}1-x} for x≥slant 0.5 are studied using neutron diffraction with aerodynamic levitation and density functional theory molecular dynamics modelling. Simulated structure factors are found to be in good agreement with experimental structure factors. Local atomic structures from simulations reveal the role of calcium cations as a network modifier, and aluminium cations as a non-tetrahedral network former. Distributions of tetrahedral order show that an increasing concentration of the network former Al increases entropy, while an increasing concentration of the network modifier Ca decreases entropy. This trend is opposite to the conventional understanding that increasing amounts of network former should increase order in the network liquid, and so decrease entropy. The two-body correlation entropy S 2 is found to not correlate with the excess entropy values obtained from thermochemical databases, while entropies including higher-order correlations such as tetrahedral order, O-M-O or M-O-M bond angles and Q N environments show a clear linear correlation between computed entropy and database excess entropy. The possible relationship between atomic structures and excess entropy is discussed.

  7. All Prime Contract Awards by State or Country, Place, and Contractor. Part 9 (Annville, Kentucky-Crofton, Maryland)

    DTIC Science & Technology

    1990-01-01

    4.44c V c- U CU4 0 1.- (A 0.0 a* .W - 0. i- -4 C10t- (D I M 6 l UN W 0 >. GN C4 i ae ad )-4N0C, D,0 P. f6 MŔ R~ = 1- (0 00 .8 (A Q 0 0 Zococ3- 00cv I...In 0 P.- CM -4 0 -4 ’I- U u I 000 Go I -16 OC) f6 ’ -4 0A 0 CN - Ll.UC I oo r WNI 00 0 16060 I toN 4: N f 0 L I. I OP.- U -4 -. 4.4 -4 .4.4 .- 46. 4...00 "M M 0i 201(f 1 E00 -4 N)x 0 0 0 Q 0x- 0 0 F6 . Co C4- NI- al 2 0 Wi U) ~ ~ 1. C.) ai a 1 I0 04 N U)N-mN-NN -. 0-4- 1- 4 1.( 4-4 4 (Y00 0 ) -e4 n N

  8. Daily Magnetograms for 1982 from the AFGL (Air Force Geophysics Laboratory) Network.

    DTIC Science & Technology

    1985-03-01

    who as a IN high-school student, carried out much of the computer work that produced the A edited data shown in these plots and who lost his life in...34,. . .. . . . . .. .. .. .. . . . . .. . . . . . .. . . . . .. . ... .. . . .... .. .. .... *... II * .- eeee OM 04eO 66 eeee OMe IM 12 14e9 1600 18 2M 22 66 .’.W 06 A 82 (DAY 82.M6) UIVERSAL TIrE WGL...lit’ 54437 1 S4571 55315 S32Sg9. .5 42871 F, .. . . . . . . .- - - 88 MW 82 (DAY 82.128) UIVERSAL TIME AFGL MAGN~ETEER PETUFlJ 135

  9. ITER Baseline Scenario with ECCD Applied to Neoclassical Tearing Modes in DIII-D

    NASA Astrophysics Data System (ADS)

    Welander, A. G.; La Haye, R. J.; Lohr, J. M.; Humphreys, D. A.; Prater, R.; Paz-Soldan, C.; Kolemen, E.; Turco, F.; Olofsson, E.

    2015-11-01

    The neoclassical tearing mode (NTM) is a magnetic island that can occur on flux surfaces where the safety factor q is a rational number. Both m/n=3/2 and 2/1 NTM's degrade confinement, and the 2/1 mode often locks to the wall and disrupts the plasma. An NTM can be suppressed by depositing electron cyclotron current drive (ECCD) on the q-surface by injecting microwave beams into the plasma from gyrotrons. Recent DIII-D experiments have studied the application of ECCD/ECRH in the ITER Baseline Scenario. The power required from the gyrotrons can be significant enough to impact the fusion gain, Q in ITER. However, if gyrotron power could be minimized or turned off in ITER when not needed, this impact would be small. In fact, tearing-stable operation at low torque has been achieved previously in DIII-D without EC power. A vision for NTM control in ITER will be described together with results obtained from simulations and experiments in DIII-D under ITER like conditions. Work supported by the US DOE under DE-FC02-04ER54698, DE-AC02-09CH11466, DE-FG02-04ER54761.

  10. Modeling, Analysis, and Impedance Design of Battery Energy Stored Single-Phase Quasi-Z Source Photovoltaic Inverter System

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Xue, Yaosuo

    The battery energy stored quasi-Z-source (BES-qZS) based photovoltaic (PV) power generation system combines advantages of the qZS inverter and the battery energy storage system. However, the second harmonic (2 ) power ripple will degrade the system's performance and affect the system's design. An accurate model to analyze the 2 ripple is very important. The existing models did not consider the battery, and with the assumption L1=L2 and C1=C2, which causes the non-optimized design for the impedance parameters of qZS network. This paper proposes a comprehensive model for single-phase BES-qZS-PV inverter system, where the battery is considered and without any restrictionmore » of L1, L2, C1, and C2. A BES-qZS impedance design method based on the built model is proposed to mitigate the 2 ripple. Simulation and experimental results verify the proposed 2 ripple model and design method.« less

  11. Development of Structural Covariance From Childhood to Adolescence: A Longitudinal Study in 22q11.2DS.

    PubMed

    Sandini, Corrado; Zöller, Daniela; Scariati, Elisa; Padula, Maria C; Schneider, Maude; Schaer, Marie; Van De Ville, Dimitri; Eliez, Stephan

    2018-01-01

    Background: Schizophrenia is currently considered a neurodevelopmental disorder of connectivity. Still few studies have investigated how brain networks develop in children and adolescents who are at risk for developing psychosis. 22q11.2 Deletion Syndrome (22q11DS) offers a unique opportunity to investigate the pathogenesis of schizophrenia from a neurodevelopmental perspective. Structural covariance (SC) is a powerful approach to explore morphometric relations between brain regions that can furthermore detect biomarkers of psychosis, both in 22q11DS and in the general population. Methods: Here we implement a state-of-the-art sliding-window approach to characterize maturation of SC network architecture in a large longitudinal cohort of patients with 22q11DS (110 with 221 visits) and healthy controls (117 with 211 visits). We furthermore propose a new clustering-based approach to group regions according to trajectories of structural connectivity maturation. We correlate measures of SC with development of working memory, a core executive function that is highly affected in both idiopathic psychosis and 22q11DS. Finally, in 22q11DS we explore correlations between SC dysconnectivity and severity of internalizing psychopathology. Results: In HCs network architecture underwent a quadratic developmental trajectory maturing up to mid-adolescence. Late-childhood maturation was particularly evident for fronto-parietal cortices, while Default-Mode-Network-related regions showed a more protracted linear development. Working memory performance was positively correlated with network segregation and fronto-parietal connectivity. In 22q11DS, we demonstrate aberrant maturation of SC with disturbed architecture selectively emerging during adolescence and correlating more severe internalizing psychopathology. Patients also presented a lack of typical network development during late-childhood, that was particularly prominent for frontal connectivity. Conclusions: Our results suggest that SC maturation may underlie critical cognitive development occurring during late-childhood in healthy controls. Aberrant trajectories of SC maturation may reflect core developmental features of 22q11DS, including disturbed cognitive maturation during childhood and predisposition to internalizing psychopathology and psychosis during adolescence.

  12. Competing contact processes in the Watts-Strogatz network

    NASA Astrophysics Data System (ADS)

    Rybak, Marcin; Malarz, Krzysztof; Kułakowski, Krzysztof

    2016-06-01

    We investigate two competing contact processes on a set of Watts-Strogatz networks with the clustering coefficient tuned by rewiring. The base for network construction is one-dimensional chain of N sites, where each site i is directly linked to nodes labelled as i ± 1 and i ± 2. So initially, each node has the same degree k i = 4. The periodic boundary conditions are assumed as well. For each node i the links to sites i + 1 and i + 2 are rewired to two randomly selected nodes so far not-connected to node i. An increase of the rewiring probability q influences the nodes degree distribution and the network clusterization coefficient 𝓒. For given values of rewiring probability q the set 𝓝(q)={𝓝1,𝓝2,...,𝓝 M } of M networks is generated. The network's nodes are decorated with spin-like variables s i ∈ { S,D }. During simulation each S node having a D-site in its neighbourhood converts this neighbour from D to S state. Conversely, a node in D state having at least one neighbour also in state D-state converts all nearest-neighbours of this pair into D-state. The latter is realized with probability p. We plot the dependence of the nodes S final density n S T on initial nodes S fraction n S 0. Then, we construct the surface of the unstable fixed points in (𝓒, p, n S 0) space. The system evolves more often toward n S T for (𝓒, p, n S 0) points situated above this surface while starting simulation with (𝓒, p, n S 0) parameters situated below this surface leads system to n S T =0. The points on this surface correspond to such value of initial fraction n S * of S nodes (for fixed values 𝓒 and p) for which their final density is n S T=1/2.

  13. 24 CFR 14.100 - Time computation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Time computation. 14.100 Section 14... IMPLEMENTATION OF THE EQUAL ACCESS TO JUSTICE ACT IN ADMINISTRATIVE PROCEEDINGS General Provisions § 14.100 Time computation. Time periods stated in this part shall be computed in accordance with the Department's rules with...

  14. 24 CFR 180.405 - Time computations.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Time computations. 180.405 Section... Hearing § 180.405 Time computations. (a) In computing time under this part, the time period begins the day... Saturday, Sunday, or legal holiday observed by the Federal Government, in which case the time period...

  15. 24 CFR 26.11 - Time computation.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Time computation. 26.11 Section 26... HEARING PROCEDURES Hearings Before Hearing Officers Pleadings and Motions § 26.11 Time computation. (a) Generally. Computation of any period of time prescribed or allowed by this part shall begin with the first...

  16. 24 CFR 180.405 - Time computations.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Time computations. 180.405 Section... Hearing § 180.405 Time computations. (a) In computing time under this part, the time period begins the day... Saturday, Sunday, or legal holiday observed by the Federal Government, in which case the time period...

  17. 24 CFR 14.100 - Time computation.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 1 2014-04-01 2014-04-01 false Time computation. 14.100 Section 14... IMPLEMENTATION OF THE EQUAL ACCESS TO JUSTICE ACT IN ADMINISTRATIVE PROCEEDINGS General Provisions § 14.100 Time computation. Time periods stated in this part shall be computed in accordance with the Department's rules with...

  18. 24 CFR 14.100 - Time computation.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Time computation. 14.100 Section 14... IMPLEMENTATION OF THE EQUAL ACCESS TO JUSTICE ACT IN ADMINISTRATIVE PROCEEDINGS General Provisions § 14.100 Time computation. Time periods stated in this part shall be computed in accordance with the Department's rules with...

  19. 24 CFR 26.11 - Time computation.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Time computation. 26.11 Section 26... HEARING PROCEDURES Hearings Before Hearing Officers Pleadings and Motions § 26.11 Time computation. (a) Generally. Computation of any period of time prescribed or allowed by this part shall begin with the first...

  20. 24 CFR 14.100 - Time computation.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 1 2013-04-01 2013-04-01 false Time computation. 14.100 Section 14... IMPLEMENTATION OF THE EQUAL ACCESS TO JUSTICE ACT IN ADMINISTRATIVE PROCEEDINGS General Provisions § 14.100 Time computation. Time periods stated in this part shall be computed in accordance with the Department's rules with...

  1. 24 CFR 14.100 - Time computation.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Time computation. 14.100 Section 14... IMPLEMENTATION OF THE EQUAL ACCESS TO JUSTICE ACT IN ADMINISTRATIVE PROCEEDINGS General Provisions § 14.100 Time computation. Time periods stated in this part shall be computed in accordance with the Department's rules with...

  2. Scattering of Tone Bursts from Spherical Shells: Computations Based on Fourier Transform Method.

    DTIC Science & Technology

    1991-08-30

    0 SALP =0. 0 N1=0 SUM=0. 0 CALL STVAL(X,X1,X2 ,ALPN, BETN,CBN1, BN1,SNN1,RH,XSN,X2S,XCS) 20 CONTINUE CE-N2= PCB(N+3)/PCB(N+2) Q=FLOAT (N+1) 88 ANUM-(Q...BETN*BETN1)) FAC=XSIGN* (2. 0*Q-1. 0) SALP = SALP +FAC*ALPN SBET=SBET+FAC* BETN ALPN=ALPN1 BETN=BETN1 SUM=SUM+ADD IF ((ABS(ADD/SUM)).LT.1.OE-8) GO TO 90...J=O N=N±1 XSIGN=-XSIGN GO TO 20 90 J=J+1 IF (J.EQ.5) GO TO 100 N=N+1 XSIGN=-XSIGN GO TO 20 100 YP=(-4.0/(X**2))*SUM FAC=-XSIGN* (2. 0*Q+1.0) SALP = SALP

  3. The q-dependent detrended cross-correlation analysis of stock market

    NASA Astrophysics Data System (ADS)

    Zhao, Longfeng; Li, Wei; Fenu, Andrea; Podobnik, Boris; Wang, Yougui; Stanley, H. Eugene

    2018-02-01

    Properties of the q-dependent cross-correlation matrices of the stock market have been analyzed by using random matrix theory and complex networks. The correlation structures of the fluctuations at different magnitudes have unique properties. The cross-correlations among small fluctuations are much stronger than those among large fluctuations. The large and small fluctuations are dominated by different groups of stocks. We use complex network representation to study these q-dependent matrices and discover some new identities. By utilizing those q-dependent correlation-based networks, we are able to construct some portfolios of those more independent stocks which consistently perform better. The optimal multifractal order for portfolio optimization is around q  =  2 under the mean-variance portfolio framework, and q\\in[2, 6] under the expected shortfall criterion. These results have deepened our understanding regarding the collective behavior of the complex financial system.

  4. Auscultation des barrages en beton par ecoute microsismique: Detectabilite et localisation des evenements

    NASA Astrophysics Data System (ADS)

    Giroux, Bernard

    The aging of dams leads to their degradation and is therefore a threat to normal operation, and is potentially dangerous. Ideally, a method continuously monitoring the majority of the structure would help considerably the management of operations. The feasibility of such a technique is the topic of this thesis. The principle underlying the proposed method is to listen to microseismic events generated by the cracking of the concrete dam. A method based on this principle is used to detect and attempt to predict rockbursts in the mining industry. The method procedure is the following: given a sensor network distributed over a dam, one wishes to detect the microseismic events emitted by structure cracking, to locate the source in space and time, and ultimately to characterize the stress field causing the emission. The seismic quality factor Q is usually used to quantify attenuation. Presented is a technique to reduce the noise bias in the calculation of the amplitude spectrum ratio. The results so obtained show a Q factor of order ranging from 5 to 10. A new method using genetic algorithms is presented to evaluate Q and the coupling jointly. According to our results, sensor coupling varies from 0,2 to 0,8. The corresponding Q factor attains a value of 60. Also, the ambient noise level must be known in order to establish from which distance the seismic energy can be measured. Reference RMS values of 10-5 m/s for velocity and 10-1 m/s 2 for acceleration are used as an upper limit for the computation of a so-called "critical detection radius". Thirdly, the seismic responses of circular cracks having areas of 0,01, 0,1 and 1,0 m2 were computed for a model equivalent to the Carillon Dam, for Q values varying from 5 to 100. Considering that an adequate coupling can be obtained (equivalent to Q = 50) and that a signal to noise ratio of 100 allows for the detection of the seismic signal, one can expect to detect an event caused by a 0,01 m 2 defect at a distance of 25 m. In the second part of this work, a method for locating the seismic sources based on the joint hypocenter-velocity inversion of traveltime data is presented. The inversion method relies on raytrace forward modeling. This method was tested and implemented in the inversion code. Finally, tests with synthetic data were conducted to assess the performance of the inversion program. The results show that an accurate location is achieved with about ten sensors, provided that some sensors are placed at the upstream base of the structure, the remainder being on the crest and downstream side of the dam. (Abstract shortened by UMI.)

  5. Enhancing robustness and immunization in geographical networks

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Huang Liang; Department of Physics, Lanzhou University, Lanzhou 730000; Yang Kongqing

    2007-03-15

    We find that different geographical structures of networks lead to varied percolation thresholds, although these networks may have similar abstract topological structures. Thus, strategies for enhancing robustness and immunization of a geographical network are proposed. Using the generating function formalism, we obtain an explicit form of the percolation threshold q{sub c} for networks containing arbitrary order cycles. For three-cycles, the dependence of q{sub c} on the clustering coefficients is ascertained. The analysis substantiates the validity of the strategies with analytical evidence.

  6. The effectiveness of an interactive computer program versus traditional lecture in athletic training education.

    PubMed

    Wiksten, D L; Patterson, P; Antonio, K; De La Cruz, D; Buxton, B P

    1998-07-01

    To evaluate the effectiveness of an interactive athletic training educational curriculum (IATEC) computer program as compared with traditional lecture instruction. Instructions on assessment of the quadriceps angle (Q-angle) were compared. Dependent measures consisted of cognitive knowledge, practical skill assessment, and attitudes toward the 2 methods of instruction. Sixty-six subjects were selected and then randomly assigned to 3 different groups: traditional lecture, IATEC, and control. The traditional lecture group (n = 22) received a 50-minute lecture/demonstration covering the same instructional content as the Q-angle module of the IATEC program. The IATEC group (n = 20; 2 subjects were dropped from this group due to scheduling conflicts) worked independently for 50 to 65 minutes using the Q-angle module of the IATEC program. The control group (n = 22) received no instruction. Subjects were recruited from an undergraduate athletic training education program and were screened for prior knowledge of the Q-angle. A 9-point multiple choice examination was used to determine cognitive knowledge of the Q-angle. A 12-point yes-no checklist was used to determine whether or not the subjects were able to correctly measure the Q-angle. The Allen Attitude Toward Computer-Assisted Instruction Semantic Differential Survey was used to assess student attitudes toward the 2 methods of instruction. The survey examined overall attitudes, in addition to 3 subscales: comfort, creativity, and function. The survey was scored from 1 to 7, with 7 being the most favorable and 1 being the least favorable. Results of a 1-way ANOVA on cognitive knowledge of the Q-angle revealed that the traditional lecture and IATEC groups performed significantly better than the control group, and the traditional lecture group performed significantly better than the IATEC group. Results of a 1-way ANOVA on practical skill performance revealed that the traditional lecture and IATEC groups performed significantly better than the control group, but there were no significant differences between the traditional lecture and IATEC groups on practical skill performance. Results of a t test indicated significantly more favorable attitudes (P < .05) for the traditional lecture group when compared with the IATEC group for comfort, creativity, and function. Our results suggest that use of the IATEC computer module is an effective means of instruction; however, use of the IATEC program alone may not be sufficient for educating students in cognitive knowledge. Further research is needed to determine the effectiveness of the IATEC computer program as a supplement to traditional lecture instruction in athletic training education.

  7. The Effectiveness of an Interactive Computer Program Versus Traditional Lecture in Athletic Training Education

    PubMed Central

    Wiksten, Denise Lebsack; Patterson, Patricia; Antonio, Kimberly; De La Cruz, Daniel; Buxton, Barton P.

    1998-01-01

    Objective: To evaluate the effectiveness of an interactive athletic training educational curriculum (IATEC) computer program as compared with traditional lecture instruction. Instructions on assessment of the quadriceps angle (Q-angle) were compared. Dependent measures consisted of cognitive knowledge, practical skill assessment, and attitudes toward the 2 methods of instruction. Design and Setting: Sixty-six subjects were selected and then randomly assigned to 3 different groups: traditional lecture, IATEC, and control. The traditional lecture group (n = 22) received a 50-minute lecture/demonstration covering the same instructional content as the Q-angle module of the IATEC program. The IATEC group (n = 20; 2 subjects were dropped from this group due to scheduling conflicts) worked independently for 50 to 65 minutes using the Q-angle module of the IATEC program. The control group (n = 22) received no instruction. Subjects: Subjects were recruited from an undergraduate athletic training education program and were screened for prior knowledge of the Q-angle. Measurements: A 9-point multiple choice examination was used to determine cognitive knowledge of the Q-angle. A 12-point yes-no checklist was used to determine whether or not the subjects were able to correctly measure the Q-angle. The Allen Attitude Toward Computer-Assisted Instruction Semantic Differential Survey was used to assess student attitudes toward the 2 methods of instruction. The survey examined overall attitudes, in addition to 3 subscales: comfort, creativity, and function. The survey was scored from 1 to 7, with 7 being the most favorable and 1 being the least favorable. Results: Results of a 1-way ANOVA on cognitive knowledge of the Q-angle revealed that the traditional lecture and IATEC groups performed significantly better than the control group, and the traditional lecture group performed significantly better than the IATEC group. Results of a 1-way ANOVA on practical skill performance revealed that the traditional lecture and IATEC groups performed significantly better than the control group, but there were no significant differences between the traditional lecture and IATEC groups on practical skill performance. Results of a t test indicated significantly more favorable attitudes (P < .05) for the traditional lecture group when compared with the IATEC group for comfort, creativity, and function. Conclusions: Our results suggest that use of the IATEC computer module is an effective means of instruction; however, use of the IATEC program alone may not be sufficient for educating students in cognitive knowledge. Further research is needed to determine the effectiveness of the IATEC computer program as a supplement to traditional lecture instruction in athletic training education. PMID:16558517

  8. Geographic List of Prime Contract Awards. Oct 91 - Sep 92. FY92. (Bridgeville Delaware - Key Biscayne)

    DTIC Science & Technology

    1993-01-01

    N (4-1 r4 N1 + not I Ooc’) i1t z 0 0)0)toooooo 0)0 GAO )()(7 )0() 00) to Z a) 0) C) () tooott (7 )0)00 at o IMO "N Ito UA 𔃾C < 1 MtON 8(4 4f o 8-4 Q...0) 1 DOC>-* 11 to -4 C, Wac)CDC)40 0) -4 C> C> -4 0 to ýq M 0 U I MOýt of -J M 04 C1,J N CM " -IT M -4 CY) Cl) M Cn - JINI -4 -j C1) m C*4 -it RT -JC

  9. Security of two quantum cryptography protocols using the same four qubit states

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Branciard, Cyril; Ecole Nationale Superieure des Telecommunications, 46, rue Barrault, 75013 Paris; Gisin, Nicolas

    2005-09-15

    The first quantum cryptography protocol, proposed by Bennett and Brassard in 1984 (BB84), has been widely studied in recent years. This protocol uses four states (more precisely, two complementary bases) for the encoding of the classical bit. Recently, it has been noticed that by using the same four states, but a different encoding of information, one can define a protocol which is more robust in practical implementations, specifically when attenuated laser pulses are used instead of single-photon sources [V. Scarani et al., Phys. Rev. Lett. 92, 057901 (2004), referred to as the SARG04 protocol]. We present a detailed study ofmore » SARG04 in two different regimes. In the first part, we consider an implementation with a single-photon source: we derive bounds on the error rate Q for security against all possible attacks by the eavesdropper. The lower and the upper bound obtained for SARG04 (Q < or approx. 10.95% and Q > or approx. 14.9%, respectively) are close to those obtained for BB84 (Q < or approx. 12.4% and Q > or approx. 14.6%, respectively). In the second part, we consider a realistic source consisting of an attenuated laser and improve on previous analysis by allowing Alice to optimize the mean number of photons as a function of the distance. The SARG04 protocol is found to perform better than BB84, both in secret-key rate and in maximal achievable distance, for a wide class of Eve's attacks.« less

  10. Data collection outcomes comparing paper forms with PDA forms in an office-based patient survey.

    PubMed

    Galliher, James M; Stewart, Thomas V; Pathak, Paramod K; Werner, James J; Dickinson, L Miriam; Hickner, John M

    2008-01-01

    We compared the completeness of data collection using paper forms and using electronic forms loaded on handheld computers in an office-based patient interview survey conducted within the American Academy of Family Physicians National Research Network. We asked 19 medical assistants and nurses in family practices to administer a survey about pneumococcal immunizations to 60 older adults each, 30 using paper forms and 30 using electronic forms on handheld computers. By random assignment, the interviewers used either the paper or electronic form first. Using multilevel analyses adjusted for patient characteristics and clustering of forms by practice, we analyzed the completeness of the data. A total of 1,003 of the expected 1,140 forms were returned to the data center. The overall return rate was better for paper forms (537 of 570, 94%) than for electronic forms (466 of 570, 82%) because of technical difficulties experienced with electronic data collection and stolen or lost handheld computers. Errors of omission on the returned forms, however, were more common using paper forms. Of the returned forms, only 3% of those gathered electronically had errors of omission, compared with 35% of those gathered on paper. Similarly, only 0.04% of total survey items were missing on the electronic forms, compared with 3.5% of the survey items using paper forms. Although handheld computers produced more complete data than the paper method for the returned forms, they were not superior because of the large amount of missing data due to technical difficulties with the hand-held computers or loss or theft. Other hardware solutions, such as tablet computers or cell phones linked via a wireless network directly to a Web site, may be better electronic solutions for the future.

  11. Strong Relation between Muscle Mass Determined by D3-creatine Dilution, Physical Performance and Incidence of Falls and Mobility Limitations in a Prospective Cohort of Older Men.

    PubMed

    Cawthon, Peggy M; Orwoll, Eric S; Peters, Katherine E; Ensrud, Kristine E; Cauley, Jane A; Kado, Deborah M; Stefanick, Marcia L; Shikany, James M; Strotmeyer, Elsa S; Glynn, Nancy W; Caserotti, Paolo; Shankaran, Mahalakshmi; Hellerstein, Marc; Cummings, Steven R; Evans, William J

    2018-06-12

    Direct assessment of skeletal muscle mass in older adults is clinically challenging. Relationships between lean mass and late-life outcomes have been inconsistent. The D3-creatine dilution method provides a direct assessment of muscle mass. Muscle mass was assessed by D3-creatine (D3Cr) dilution in 1,382 men (mean age, 84.2 yrs). Participants completed the Short Physical Performance Battery (SPPB); usual walking speed (6 meters); and DXA lean mass. Men self-reported mobility limitations (difficulty walking 2-3 blocks or climbing 10 steps); recurrent falls (2+); and serious injurious falls in the subsequent year. Across quartiles of D3Cr muscle mass/body mass, multivariate linear models calculated means for SPPB and gait speed; multivariate logistic models calculated odds ratios for incident mobility limitations or falls. Compared to men in the highest quartile, those in the lowest quartile of D3Cr muscle mass/body mass had slower gait speed (Q1: 1.04 vs Q4: 1.17 m/s); lower SPPB (Q1: 8.4 vs Q4: 10.4 points); greater likelihood of incident serious injurious falls (OR Q1 vs Q4: 2.49, 95% CI: 1.37, 4.54); prevalent mobility limitation (OR Q1 vs Q4,: 6.1, 95%CI: 3.7, 10.3) and incident mobility limitation (OR Q1 vs Q4: 2.15 95% CI: 1.42, 3.26); p for trend <.001 for all. Results for incident recurrent falls were in the similar direction (p=0.156). DXA lean mass had weaker associations with the outcomes. Unlike DXA lean mass, low D3Cr muscle mass/body mass is strongly related to physical performance, mobility and incident injurious falls in older me.

  12. Development and Application of a New Learning Object for Teaching Operative Dentistry Using Augmented Reality.

    PubMed

    Espejo-Trung, Luciana Cardoso; Elian, Silvia Nagib; Luz, Maria Aparecia Alves De Cerqueira

    2015-11-01

    Learning objects (LOs) associated with augmented reality have been used as attractive new technologic tools in the educational process. However, the acceptance of new LOs must be verified with the purpose of using these innovations in the learning process in general. The aim of this study was to develop a new LO and investigate the acceptance of gold onlay in teaching preparation design at a dental school in Brazil. Questionnaires were designed to assess, first, the users' computational ability and knowledge of computers (Q1) and, second, the users' acceptance of the new LO (Q2). For both questionnaires, the internal consistency index was calculated to determine whether the questions were measuring the same construct. The reliability of Q2 was measured with a retest procedure. The LO was tested by dental students (n=28), professors and postgraduate students in dentistry and prosthetics (n=30), and dentists participating in a continuing education or remedial course in dentistry and/or prosthetics (n=19). Analyses of internal consistency (Kappa coefficient and Cronbach's alpha) demonstrated a high degree of confidence in the questionnaires. Tests for simple linear regressions were conducted between the response variable (Q2) and the following explanative variables: the Q1 score, age, gender, and group. The results showed wide acceptance regardless of the subjects' computational ability (p=0.99; R2=0), gender (p=0.27; R2=1.6%), age (p=0.27; R2=0.1%), or group (p=0.53; R2=1.9%). The methodology used enabled the development of an LO with a high index of acceptance for all groups.

  13. Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place. Part 17 (Ray Industries-Service Screw Company Inc)

    DTIC Science & Technology

    1990-01-01

    0c) Cc) Nf 1 (04N< 11 L)(0 H.r)O) ( 61010 -40,0) 00)0) .CNNNNNNNN L. 0 *-e) N I(.4N< Il0001 11 ) CYO tnc(yc >0(3c i~ CY CYCFCYacaaaaCV o or( .mCY.. I...0 - 1 W- 0 I- 9XN 1n L 0- 9 N o it ICO M-4 (0 2- 0 .c 0 w -j Z F-11011= C’. 114 Z z0 0 0 Q -1 0 x wJ w 0 IEC M-4 0t LU4 0 0 0 0-q 4-C) 1-- 0 -4(0- oo...C’, N " NN 0 N MM~tN-04 to N~ -4 C0 (0) 0 (0(0 N Nl MI en0 10)00-4-40 0 -4 0 C00 0 -1 00 -4 -4 Mf~ Iec ’ II-00(0(00o 0 (0) 0 00 0 0(0 000 47) (0 all

  14. Construction of small plasmid vectors for use in genetic improvement of the extremely acidophilic Acidithiobacillus caldus.

    PubMed

    Meng, Jianzhou; Wang, Huiyan; Liu, Xiangmei; Lin, Jianqun; Pang, Xin; Lin, Jianqiang

    2013-10-01

    The genetic improvement of biomining bacteria including Acidithiobacillus caldus could facilitate the bioleaching process of sulfur-containing minerals. However, the available vectors for use in A. caldus are very scanty and limited to relatively large broad-host-range IncQ plasmids. In this study, a set of small, mobilizable plasmid vectors (pBBR1MCS-6, pMSD1 and pMSD2) were constructed based on plasmid pBBR1MCS-2, which does not belong to the IncQ, IncW, or IncP groups. The function of the tac promoter on 5.8-kb pMSD2 was determined by inserting a kanamycin-resistant reporter gene. The resulting recombinant pMSD2-Km was successfully transferred by conjugation into A. caldus MTH-04 with transfer frequency of 1.38±0.64×10(-5). The stability and plasmid copy number of pMSD2-Km in A. caldus MTH-04 were 75±2.7% and 5-6 copies per cell, respectively. By inserting an arsABC operon into pMSD2, an arsenic-resistant recombinant pMSD2-As was constructed and transferred into A. caldus MTH-04 by conjugation. The arsenic tolerance of A. caldus MTH-04 containing pMSD2-As was obviously increased up to 45mM of NaAsO2. These vectors could be applied in genetic improvement of A. caldus as well as other bioleaching bacteria. Copyright © 2013 Elsevier GmbH. All rights reserved.

  15. Department of the Navy Justification of Estimates Amended Fiscal Year 1988 and 1989 Biennial Budget Submitted to Congress February 1988. Operation and Maintenance, Navy. Book 3. Budget Activity 8: Training Medical and OPGA Budget Activity 9: Administration and Assoc Acts. Budget Activity 10: Support to Other Nations Budget Activity 11: Special Operations Forces

    DTIC Science & Technology

    1988-02-01

    8217dCL D~0U :2aw u> Q >0.’a 41 ’ 0 :1:5 - r.4 J0)C.Ř£ to 4 td " C CO to) U) 0 " A. O cw 0 > ;3 w 4 144 w. V).M t 00 J - 4bD £ (d Ŕ 3.0 bcL W 0 .𔃾 0) 03 J...to -4 0 4) 44 41 P-4 Ma to 04 to W 0) M V) W 41 :b% Cý .,q r. ed -m 0 td rd .- a to w to w w to "-4 as 44 r-.4 w 1-4 W w (v to ow ýj M to) C: to CL (1...P -4P0-4 oo W v w ~’L0 . V)4) >%r.0 4w D bo 1-ý40 U G) 0 w w H 0ww 0 w0..4.J. 9 . 40. 𔃺 -1 4 0 WL O.1-w ý400.0 A. ’c-c 0I v’- U w 1 -4U0w ( td (0 L

  16. Walkability around primary schools and area deprivation across Scotland.

    PubMed

    Macdonald, Laura; McCrorie, Paul; Nicholls, Natalie; Ellaway, Anne

    2016-04-14

    A number of studies based in the US, Canada, and Australia, have found evidence of associations between the built environment (BE) and mode of transport to school, and links between active travel and deprivation. Limited research in the UK compares potential BE supports for walking to school by area deprivation. Within this study, we gathered data on BE attributes previously linked to active travel, i.e., street/path connectivity, and dwelling density, created a composite 'walkability score' (WS) for areas around primary schools across urban Scotland, and explored whether poorer areas exhibit lower scores than more affluent areas, or vice versa. We consider this to be a novel approach as few studies have compared BE features by deprivation across a whole country. Address and road/path maps were obtained and primary schools (N = 937) across mainland Scotland were mapped. Schools were attributed income deprivation scores (scores divided into quintiles (Q1: least deprived, Q5: most deprived)). Catchment area (CA) boundaries, i.e., the geographic area representing eligibility for local school attendance, were drawn around schools, and WS calculated for each CA. We compared mean WS by income quintile (ANOVA), for all local authorities (LAs) combined (N = 29), and separately for the four LAs with the greatest number of schools included in the analysis. For all LAs combined, the least deprived quintile (Q1) showed a significantly lower WS (-0.61), than quintiles 3, 4 and 5 (Q2: -0.04 (non-sig), Q3: 0.38, Q4: 0.09, Q5: 0.18); while for Glasgow the second least deprived quintile (Q2) showed significantly higher WS (Q1: 1.35, Q2: 1.73), than middling (Q3: 0.18) and most deprived quintiles (Q4: 0.06, Q5: -0.10). WS differ by deprivation with patterns varying depending on the spatial scale of the analysis. It is essential that less walkable areas are provided with the resources to improve opportunities to engage in active travel.

  17. Shared susceptibility loci at 2q33 region for lung and esophageal cancers in high-incidence areas of esophageal cancer in northern China

    PubMed Central

    Song, Xin; Hu, Shou Jia; Lv, Shuang; Cheng, Rang; Zhang, Tang Juan; Han, Xue Na; Ren, Jing Li; Qi, Yi Jun

    2017-01-01

    Background Cancers from lung and esophagus are the leading causes of cancer-related deaths in China and share many similarities in terms of histological type, risk factors and genetic variants. Recent genome-wide association studies (GWAS) in Chinese esophageal cancer patients have demonstrated six high-risk candidate single nucleotide polymorphisms (SNPs). Thus, the present study aimed to determine the risk of these SNPs predisposing to lung cancer in Chinese population. Methods A total of 1170 lung cancer patients and 1530 normal subjects were enrolled in this study from high-incidence areas for esophageal cancer in Henan, northern China. Five milliliters of blood were collected from all subjects for genotyping. Genotyping of 20 high-risk SNP loci identified from genome-wide association studies (GWAS) on esophageal, lung and gastric cancers was performed using TaqMan allelic discrimination assays. Polymorphisms were examined for deviation from Hardy-Weinberg equilibrium (HWE) using Х2 test. Bonferroni correction was performed to correct the statistical significance of 20 SNPs with the risk of lung cancer. The Pearson’s Х2 test was used to compare the distributions of gender, TNM stage, histopathological type, smoking and family history by lung susceptibility genotypes. Kaplan-Meier and Cox regression analyses were carried out to evaluate the associations between genetic variants and overall survival. Results Four of the 20 SNPs identified as high-risk SNPs in Chinese esophageal cancer showed increased risk for Chinese lung cancer, which included rs3769823 (OR = 1.26; 95% CI = 1.107–1.509; P = 0.02), rs10931936 (OR = 1.283; 95% CI = 1.100–1.495; P = 0.04), rs2244438 (OR = 1.294; 95% CI = 1.098–1.525; P = 0.04) and rs13016963 (OR = 1.268; 95% CI = 1.089–1.447; P = 0.04). All these SNPs were located at 2q33 region harboringgenes of CASP8, ALS2CR12 and TRAK2. However, none of these susceptibility SNPs was observed to be significantly associated with gender, TNM stage, histopathological type, smoking, family history and overall survival. Conclusions The present study identified four high-risk SNPs at 2q33 locus for Chinese lung cancer and demonstrated the shared susceptibility loci at 2q33 region for Chinese lung and esophageal cancers. PMID:28542283

  18. Shared susceptibility loci at 2q33 region for lung and esophageal cancers in high-incidence areas of esophageal cancer in northern China.

    PubMed

    Zhao, Xue Ke; Mao, Yi Min; Meng, Hui; Song, Xin; Hu, Shou Jia; Lv, Shuang; Cheng, Rang; Zhang, Tang Juan; Han, Xue Na; Ren, Jing Li; Qi, Yi Jun; Wang, Li Dong

    2017-01-01

    Cancers from lung and esophagus are the leading causes of cancer-related deaths in China and share many similarities in terms of histological type, risk factors and genetic variants. Recent genome-wide association studies (GWAS) in Chinese esophageal cancer patients have demonstrated six high-risk candidate single nucleotide polymorphisms (SNPs). Thus, the present study aimed to determine the risk of these SNPs predisposing to lung cancer in Chinese population. A total of 1170 lung cancer patients and 1530 normal subjects were enrolled in this study from high-incidence areas for esophageal cancer in Henan, northern China. Five milliliters of blood were collected from all subjects for genotyping. Genotyping of 20 high-risk SNP loci identified from genome-wide association studies (GWAS) on esophageal, lung and gastric cancers was performed using TaqMan allelic discrimination assays. Polymorphisms were examined for deviation from Hardy-Weinberg equilibrium (HWE) using Х2 test. Bonferroni correction was performed to correct the statistical significance of 20 SNPs with the risk of lung cancer. The Pearson's Х2 test was used to compare the distributions of gender, TNM stage, histopathological type, smoking and family history by lung susceptibility genotypes. Kaplan-Meier and Cox regression analyses were carried out to evaluate the associations between genetic variants and overall survival. Four of the 20 SNPs identified as high-risk SNPs in Chinese esophageal cancer showed increased risk for Chinese lung cancer, which included rs3769823 (OR = 1.26; 95% CI = 1.107-1.509; P = 0.02), rs10931936 (OR = 1.283; 95% CI = 1.100-1.495; P = 0.04), rs2244438 (OR = 1.294; 95% CI = 1.098-1.525; P = 0.04) and rs13016963 (OR = 1.268; 95% CI = 1.089-1.447; P = 0.04). All these SNPs were located at 2q33 region harboringgenes of CASP8, ALS2CR12 and TRAK2. However, none of these susceptibility SNPs was observed to be significantly associated with gender, TNM stage, histopathological type, smoking, family history and overall survival. The present study identified four high-risk SNPs at 2q33 locus for Chinese lung cancer and demonstrated the shared susceptibility loci at 2q33 region for Chinese lung and esophageal cancers.

  19. Potts-model critical manifolds revisited

    DOE PAGES

    Scullard, Christian R.; Jacobsen, Jesper Lykke

    2016-02-11

    We compute the critical polynomials for the q-state Potts model on all Archimedean lattices, using a parallel implementation of the algorithm of Ref. [1] that gives us access to larger sizes than previously possible. The exact polynomials are computed for bases of size 6 6 unit cells, and the root in the temperature variable v = e K-1 is determined numerically at q = 1 for bases of size 8 8. This leads to improved results for bond percolation thresholds, and for the Potts-model critical manifolds in the real (q; v) plane. In the two most favourable cases, we findmore » now the kagome-lattice threshold to eleven digits and that of the (3; 12 2) lattice to thirteen. Our critical manifolds reveal many interesting features in the antiferromagnetic region of the Potts model, and determine accurately the extent of the Berker-Kadano phase for the lattices studied.« less

  20. Jet production in high Q 2 deep-inelastic ep scattering at HERA

    NASA Astrophysics Data System (ADS)

    Derrick, M.; Krakauer, D.; Magill, S.; Mikunas, D.; Musgrave, B.; Repond, J.; Stanek, R.; Talaga, R. L.; Zhang, H.; Avad, R.; Bari, G.; Basile, M.; Bellagamba, L.; Boscherini, D.; Bruni, A.; Bruni, G.; Bruni, P.; Romeo, G. Cara; Castellini, G.; Chiarini, M.; Cifarelli, L.; Cindolo, F.; Contin, A.; Corradi, M.; Gialas, I.; Giusti, P.; Iacobucci, G.; Laurenti, G.; Levi, G.; Margotti, A.; Massam, T.; Nania, R.; Nemoz, C.; Palmonari, E.; Polini, A.; Sartorelli, G.; Timellini, R.; Garcia, Y. Zamora; Zichichi, A.; Bargende, A.; Crittenden, J.; Desch, K.; Diekmann, B.; Doeker, T.; Eckert, M.; Feld, L.; Frey, A.; Geerts, M.; Geitz, G.; Grothe, M.; Haas, T.; Hartmann, H.; Haun, D.; Heinloth, K.; Hilger, E.; Jakob, H.-P.; Katz, U. F.; Mari, S. M.; Mass, A.; Mengel, S.; Mollen, J.; Paul, E.; Rembser, Ch.; Schattevoy, R.; Schramm, D.; Stamm, J.; Wedemeyer, R.; Campbell-Robson, S.; Cassidy, A.; Dyce, N.; Foster, B.; George, S.; Gilmore, R.; Heath, G. P.; Heath, H. F.; Llewellyn, T. J.; Morgado, C. J. S.; Norman, D. J. P.; O'Mara, J. A.; Tapper, R. I.; Wilson, S. S.; Yoshida, R.; Rau, R. R.; Arneodo, M.; Iannotti, L.; Schioppa, M.; Susinno, G.; Bernstein, A.; Caldwell, A.; Parsons, J. A.; Ritz, S.; Sciulli, F.; Straub, P. B.; Wai, L.; Yang, S.; Zhu, Q.; Borzemski, P.; Chwastowski, J.; Eskreys, A.; Piotrzkowski, K.; Zachara, M.; Zawiejski, L.; Adamczyk, L.; Bednarek, B.; Eskreys, K.; Jeleń, K.; Kisielewska, D.; Kowalski, T.; Rulikowska-Zarębska, E.; Suszycki, L.; Zając, J.; Kotański, A.; Przybycień, M.; Bauerdick, I. A. T.; Behrens, U.; Beier, H.; Bienlein, J. K.; Coldewey, C.; Deppe, O.; Desler, K.; Drews, G.; Flasiński, M.; Gilkinson, D. J.; Glasman, C.; Göttlicher, P.; Große-Knetter, J.; Gutjahr, B.; Hain, W.; Hasell, D.; Heßling, H.; Hultschig, H.; Iga, Y.; Joos, P.; Kasemann, M.; Klanner, R.; Koch, W.; Köpke, L.; Kötz, U.; Kowalski, H.; Labs, J.; Ladage, A.; Löhr, B.; Löwe, M.; Lüke, D.; Mańczak, O.; Ng, J. S. T.; Nickel, S.; Notz, D.; Ohrenberg, K.; Roco, M.; Rohde, M.; Roldán, J.; Schneekloth, U.; Schulz, W.; Selonke, F.; Stiliaris, E.; Surrow, B.; Voß, T.; Westphal, D.; Wolf, G.; Youngman, C.; Zhou, J. F.; Grabosch, H. J.; Kharchilava, A.; Leich, A.; Mattingly, M.; Meyer, A.; Schlenstedt, S.; Wulff, N.; Barbagli, G.; Pelfer, P.; Anzivino, G.; Maccarrone, G.; de Pasquale, S.; Votano, L.; Bamberger, A.; Eisenhardt, S.; Freidhof, A.; Söldner-Rembold, S.; Schroeder, J.; Trefzger, T.; Brook, N. H.; Bussey, P. J.; Doyle, A. T.; Fleck, I.; Saxon, D. H.; Utley, M. L.; Wilson, A. S.; Dannemann, A.; Holm, U.; Horstmann, D.; Neumann, T.; Sinkus, R.; Wick, K.; Badura, E.; Burow, B. D.; Hagge, L.; Lohrmann, E.; Mainusch, J.; Milewski, J.; Nakahata, M.; Pavel, N.; Poelz, G.; Schott, W.; Zetsche, F.; Bacon, T. C.; Butterworth, I.; Gallo, E.; Harris, V. L.; Hung, B. Y. H.; Long, K. R.; Miller, D. B.; Morawitz, P. P. O.; Prinias, A.; Sedgbeer, J. K.; Whitfield, A. F.; Mallik, U.; McCliment, E.; Wang, M. Z.; Wang, S. M.; Wu, J. T.; Zhang, Y.; Cloth, P.; Filges, D.; An, S. H.; Hong, S. M.; Nam, S. W.; Park, S. K.; Suh, M. H.; Yon, S. H.; Imlay, R.; Kartik, S.; Kim, H.-J.; McNeil, R. R.; Metcalf, W.; Nadendla, V. K.; Barreiro, F.; Cases, G.; Graciani, R.; Hernández, J. M.; Hervás, L.; Labarga, L.; Del Peso, J.; Puga, J.; Terron, J.; de Trocóniz, J. F.; Smith, G. R.; Corriveau, F.; Hanna, D. S.; Hartmann, J.; Hung, L. W.; Lim, J. N.; Matthews, C. G.; Patel, P. M.; Sinclair, L. E.; Stairs, D. G.; Laurent, M. St.; Ullmann, R.; Zacek, G.; Bashkirov, V.; Dolgoshein, B. A.; Stifutkin, A.; Bashindzhagyan, G. L.; Ermolov, P. F.; Gladilin, L. K.; Golubkov, Y. A.; Kobrin, V. D.; Kuzmin, V. A.; Proskuryakov, A. S.; Savin, A. A.; Shcheglova, L. M.; Solomin, A. N.; Zotov, N. P.; Botje, M.; Chlebana, F.; Dake, A.; Engelen, J.; de Kamps, M.; Kooijman, P.; Kruse, A.; Tiecke, H.; Verkerke, W.; Vreeswijk, M.; Wiggers, L.; de Wolf, E.; van Woudenberg, R.; Acosta, D.; Bylsma, B.; Durkin, L. S.; Honscheid, K.; Li, C.; Ling, T. Y.; McLean, K. W.; Murray, W. N.; Park, I. H.; Romanowski, T. A.; Seidlein, R.; Bailey, D. S.; Blair, G. A.; Byrne, A.; Cashmore, R. J.; Cooper-Sarkar, A. M.; Daniels, D.; Devenish, R. C. E.; Harnew, N.; Lancaster, M.; Luffman, P. E.; Lindemann, L.; McFall, J. D.; Nath, C.; Noyes, V. A.; Quadt, A.; Uijterwaal, H.; Walczak, R.; Wilson, F. F.; Yip, T.; Abbiendi, G.; Bertolin, A.; Brugnera, R.; Carlin, R.; Dal Corso, F.; de Giorgi, M.; Dosselli, U.; Limentani, S.; Morandin, M.; Posocco, M.; Stanco, L.; Stroili, R.; Voci, C.; Bulmahn, J.; Butterworth, J. M.; Feild, R. G.; Oh, B. Y.; Whitmore, J. J.; D'Agostini, G.; Marini, G.; Nigro, A.; Tassi, E.; Hart, J. C.; McCubbin, N. A.; Prytz, K.; Shah, T. P.; Short, T. L.; Barberis, L.; Cartiglia, N.; Dubbs, T.; Heusch, C.; van Hook, M.; Hubbard, B.; Lockman, W.; Rahn, J. T.; Sadrozinski, H. F.-W.; Seiden, A.; Biltzinger, J.; Seifert, R. J.; Walenta, A. H.; Zech, G.; Abramowicz, H.; Briskin, G.; Dagan, S.; Levy, A.; Hasegawa, T.; Hazumi, M.; Ishii, T.; Kuze, M.; Mine, S.; Nagasawa, Y.; Nakao, M.; Suzuki, I.; Tokushuku, K.; Yamada, S.; Yamazaki, Y.; Chiba, M.; Hamatsu, R.; Hirose, T.; Homma, K.; Kitamura, S.; Nakamitsu, Y.; Yamauchi, K.; Cirio, R.; Costa, M.; Ferrero, M. I.; Lamberti, L.; Maselli, S.; Peroni, C.; Sacchi, R.; Solano, A.; Staiano, A.; Dardo, M.; Bailey, D. C.; Bandyopadhyay, D.; Benard, F.; Brkic, M.; Crombie, M. B.; Gingrich, D. M.; Hartner, G. F.; Joo, K. K.; Levman, G. M.; Martin, J. F.; Orr, R. S.; Sampson, C. R.; Teuscher, R. J.; Catterall, C. D.; Jones, T. W.; Kaziewicz, P. B.; Lane, J. B.; Saunders, R. L.; Shulman, J.; Blankenship, K.; Kochocki, J.; Lu, B.; Mo, L. W.; Bogusz, W.; Charchula, K.; Ciborowski, J.; Gajewski, J.; Grzelak, G.; Kasprzak, M.; Krzyżanowski, M.; Muchorowski, K.; Nowak, R. J.; Pawlak, J. M.; Tymieniecka, T.; Wróblewski, A. K.; Zakrzewski, J. A.; Żarnecki, A. F.; Adamus, M.; Eisenberg, Y.; Karshon, U.; Revel, D.; Zer-Zion, D.; Ali, I.; Badgett, W. F.; Behrens, B.; Dasu, S.; Fordham, C.; Foudas, C.; Goussiou, A.; Loveless, R. J.; Reeder, D. D.; Silverstein, S.; Smith, W. H.; Vaiciulis, A.; Wodarczyk, M.; Tsurugai, T.; Bhadra, S.; Cardy, M. L.; Fagerstroem, C.-P.; Frisken, W. R.; Furutani, K. M.; Khakzad, M.; Schmidke, W. B.

    1995-03-01

    Two-jet production in deep-inelastic electron-proton scattering has been studied for 160< Q 2<1280 GeV2, 0.01< x<0.1 and 0.04< y<0.95 with the ZEUS detector at HERA. The kinematic properties of the jets and the jet production rates are presented. The partonic scaling variables of the two-jet system and the rate of two-jet production are compared to perturbative next-to-leading order QCD calculations.

  1. Tm:germanate Fiber Laser: Tuning And Q-switching

    NASA Technical Reports Server (NTRS)

    Barnes, Norman P.; Walsh, Brian M.; Reichle, Donald J.; DeYoung, R. J.; Jiang, Shibin

    2007-01-01

    A Tm:germanate fiber laser produced >0.25 mJ/pulse in a 45 ns pulse. It is capable of producing multiple Q-switched pulses from a single p ump pulse. With the addition of a diffraction grating, Tm:germanate f iber lasers produced a wide, but length dependent, tuning range. By s electing the fiber length, the tuning range extends from 1.88 to 2.04 ?m. These traits make Tm:germanate lasers suitable for remote sensin g of water vapor.

  2. All Prime Contract Awards by State or Country, Place, and Contractor, FY 87. Part 21. Aberdeen, Washington-Classified Location, Domestic.

    DTIC Science & Technology

    1987-01-01

    iNC*NNNN N I N IN (D 0~0 Nr I CJ " l l 1 1 N NN NN N * NNN NN NI NI Nl 001 I 0) 1 cl N N"N " C14 ciC4 0 1(4NIN 1 (NN NN N N IN COM 1 00 0 0 -1 000...000 I W IA I.- : COm -IN ML )0 4 n0- 1 - A10 ( N N M0 -0M n 00 44-4-4 M U) () 04 V(C)-CF JN00N)(’J4 4-4- - 4 Z M 0 0 0 0-4 0 -4 4 00 C 0 0 0-4 4 N0-4 0...0 V 0 - 004mI. I CoW00 < 0- I C O- COOOI - COLn 4 COA CO - CO C~O CO CO C)O4- COM - *I WOO< 40 -W 04 1W 4C 1W 1W -A -W 1W Z 04 MW 0 Q4 4 ., 4 0 44 1A

  3. Programming for 1.6 Millon cores: Early experiences with IBM's BG/Q SMP architecture

    NASA Astrophysics Data System (ADS)

    Glosli, James

    2013-03-01

    With the stall in clock cycle improvements a decade ago, the drive for computational performance has continues along a path of increasing core counts on a processor. The multi-core evolution has been expressed in both a symmetric multi processor (SMP) architecture and cpu/GPU architecture. Debates rage in the high performance computing (HPC) community which architecture best serves HPC. In this talk I will not attempt to resolve that debate but perhaps fuel it. I will discuss the experience of exploiting Sequoia, a 98304 node IBM Blue Gene/Q SMP at Lawrence Livermore National Laboratory. The advantages and challenges of leveraging the computational power BG/Q will be detailed through the discussion of two applications. The first application is a Molecular Dynamics code called ddcMD. This is a code developed over the last decade at LLNL and ported to BG/Q. The second application is a cardiac modeling code called Cardioid. This is a code that was recently designed and developed at LLNL to exploit the fine scale parallelism of BG/Q's SMP architecture. Through the lenses of these efforts I'll illustrate the need to rethink how we express and implement our computational approaches. This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.

  4. Bose-Einstein condensation in diamond hierarchical lattices.

    PubMed

    Lyra, M L; de Moura, F A B F; de Oliveira, I N; Serva, M

    2014-05-01

    The Bose-Einstein condensation of noninteracting particles restricted to move on the sites of hierarchical diamond lattices is investigated. Using a tight-binding single-particle Hamiltonian with properly rescaled hopping amplitudes, we are able to employ an orthogonal basis transformation to exactly map it on a set of decoupled linear chains with sizes and degeneracies written in terms of the network branching parameter q and generation number n. The integrated density of states is shown to have a fractal structure of gaps and degeneracies with a power-law decay at the band bottom. The spectral dimension d(s) coincides with the network topological dimension d(f) = ln(2q)/ln(2). We perform a finite-size scaling analysis of the fraction of condensed particles and specific heat to characterize the critical behavior of the BEC transition that occurs for q > 2 (d(s) > 2). The critical exponents are shown to follow those for lattices with a pure power-law spectral density, with non-mean-field values for q < 8 (d(s) < 4). The transition temperature is shown to grow monotonically with the branching parameter, obeying the relation 1/T(c) = a + b/(q - 2).

  5. A 10-Year Retrospective Comparison of Two Target Sequences, REP-529 and B1, for Toxoplasma gondii Detection by Quantitative PCR

    PubMed Central

    Belaz, Sorya; Gangneux, Jean-Pierre; Dupretz, Peggy; Guiguen, Claude

    2015-01-01

    This study aimed to evaluate the repeated sequence REP-529 compared to that of the B1 gene in the molecular diagnosis of toxoplasmosis by quantitative PCR (qPCR) in routine diagnosis. Over a 10-year period (2003 to 2013), all patients prospectively diagnosed with a positive REP-529 qPCR result for toxoplasmosis were included. All DNA samples (76 samples from 56 patients) were simultaneously tested using the two qPCR methods (REP-529 and B1). The mean cycle threshold (CT) obtained with the B1 qPCR was significantly higher (+4.71 cycles) than that obtained with REP-529 qPCR (P < 0.0001). Thirty-one out of 69 extracts (45.6%) positive with REP-529 qPCR were not amplified with the B1 qPCR (relative sensitivity of 54.4% compared to that with REP-529), yielding false-negative results with 15/28 placenta, 5 cord blood, 2 amniotic fluid, 4 cerebrospinal fluid, 1 aqueous humor, 2 lymph node puncture, and 1 abortion product sample. This defect in sensitivity would have left 20/56 patients undiagnosed, distributed as follows: 12/40 congenital toxoplasmosis, 4/5 cerebral toxoplasmosis, 2/8 patients with retinochoroiditis, and 2 patients with chronic lymphadenopathy. This poor performance of B1 qPCR might be related to low parasite loads, since the mean Toxoplasma quantification in extracts with B1 false-negative results was 0.4 parasite/reaction. These results clearly show the superiority of the REP-529 sequence in the diagnosis of toxoplasmosis by PCR and suggest that this target should be adopted as part of the standardization of the PCR assay. PMID:25653416

  6. A 10-year retrospective comparison of two target sequences, REP-529 and B1, for Toxoplasma gondii detection by quantitative PCR.

    PubMed

    Belaz, Sorya; Gangneux, Jean-Pierre; Dupretz, Peggy; Guiguen, Claude; Robert-Gangneux, Florence

    2015-04-01

    This study aimed to evaluate the repeated sequence REP-529 compared to that of the B1 gene in the molecular diagnosis of toxoplasmosis by quantitative PCR (qPCR) in routine diagnosis. Over a 10-year period (2003 to 2013), all patients prospectively diagnosed with a positive REP-529 qPCR result for toxoplasmosis were included. All DNA samples (76 samples from 56 patients) were simultaneously tested using the two qPCR methods (REP-529 and B1). The mean cycle threshold (CT) obtained with the B1 qPCR was significantly higher (+4.71 cycles) than that obtained with REP-529 qPCR (P<0.0001). Thirty-one out of 69 extracts (45.6%) positive with REP-529 qPCR were not amplified with the B1 qPCR (relative sensitivity of 54.4% compared to that with REP-529), yielding false-negative results with 15/28 placenta, 5 cord blood, 2 amniotic fluid, 4 cerebrospinal fluid, 1 aqueous humor, 2 lymph node puncture, and 1 abortion product sample. This defect in sensitivity would have left 20/56 patients undiagnosed, distributed as follows: 12/40 congenital toxoplasmosis, 4/5 cerebral toxoplasmosis, 2/8 patients with retinochoroiditis, and 2 patients with chronic lymphadenopathy. This poor performance of B1 qPCR might be related to low parasite loads, since the mean Toxoplasma quantification in extracts with B1 false-negative results was 0.4 parasite/reaction. These results clearly show the superiority of the REP-529 sequence in the diagnosis of toxoplasmosis by PCR and suggest that this target should be adopted as part of the standardization of the PCR assay. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

  7. Official Guard and Reserve Manpower Strengths and Statistics, FY 1985 Summary

    DTIC Science & Technology

    1985-01-01

    0 4% 40 4 .M 40 N M 4 41 4j 4 19i0 p 0M .49 1 41 4 0 4 M N 0 4Z4 O 4 4 " N4-4 49 4yo 41 1 4 4 49-4n l (Y 0 p 0 Mi i0 404U4in aV% 10 wi0 . 41 OD m 144...AM M - o 0v i 4K 41 4 4yo * 41 4 4 49- 4o . 4 S04 4 4t on4 4 1-0 140q 𔃺 0-I t- fmW 60q-I n 9 4K4 4 U 0Al 410-41 4u I" 4 4. 4j "M0 4LU4 f q 404 4K

  8. 26 CFR 1.527-4 - Special rules for computation of political organization taxable income.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 7 2010-04-01 2010-04-01 true Special rules for computation of political organization taxable income. 1.527-4 Section 1.527-4 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Farmers' Cooperatives § 1.527...

  9. 27 CFR 26.94 - Computation of tax.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Computation of tax. 26.94 Section 26.94 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT... Liquors and Articles in Puerto Rico Wine § 26.94 Computation of tax. On receipt of permit to compute the...

  10. 27 CFR 26.103 - Computation of tax.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2011-04-01 2011-04-01 false Computation of tax. 26.103 Section 26.103 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT... Liquors and Articles in Puerto Rico Beer § 26.103 Computation of tax. On receipt of permit to compute the...

  11. 20 CFR 340.7 - Deduction in computation of death benefit.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Deduction in computation of death benefit... UNEMPLOYMENT INSURANCE ACT RECOVERY OF BENEFITS § 340.7 Deduction in computation of death benefit. In computing... as benefits accrued to the individual but not paid at death. [57 FR 1379, Jan. 14, 1992] ...

  12. 26 CFR 1.9001-4 - Adjustments required in computing excess-profits credit.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 13 2010-04-01 2010-04-01 false Adjustments required in computing excess... Adjustments required in computing excess-profits credit. (a) In general. Subsection (f) of the Act provides adjustments required to be made in computing the excess-profits credit for any taxable year under the Excess...

  13. 25 CFR 20.313 - How will the Bureau compute financial assistance payments?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How will the Bureau compute financial assistance payments? 20.313 Section 20.313 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR HUMAN SERVICES... will the Bureau compute financial assistance payments? (a) The social services worker will compute...

  14. 20 CFR 225.3 - PIA computation formulas.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... computed under one of two normal formulas determined by the employee's eligibility year. In addition, there.... The Average Monthly Earnings PIA formula is used to compute a PIA for one of two reasons: either the... 20 Employees' Benefits 1 2014-04-01 2012-04-01 true PIA computation formulas. 225.3 Section 225.3...

  15. 20 CFR 225.3 - PIA computation formulas.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... computed under one of two normal formulas determined by the employee's eligibility year. In addition, there.... The Average Monthly Earnings PIA formula is used to compute a PIA for one of two reasons: either the... 20 Employees' Benefits 1 2013-04-01 2012-04-01 true PIA computation formulas. 225.3 Section 225.3...

  16. 20 CFR 225.3 - PIA computation formulas.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... computed under one of two normal formulas determined by the employee's eligibility year. In addition, there.... The Average Monthly Earnings PIA formula is used to compute a PIA for one of two reasons: either the... 20 Employees' Benefits 1 2012-04-01 2012-04-01 false PIA computation formulas. 225.3 Section 225.3...

  17. 20 CFR 225.3 - PIA computation formulas.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... computed under one of two normal formulas determined by the employee's eligibility year. In addition, there.... The Average Monthly Earnings PIA formula is used to compute a PIA for one of two reasons: either the... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false PIA computation formulas. 225.3 Section 225.3...

  18. 20 CFR 225.3 - PIA computation formulas.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... computed under one of two normal formulas determined by the employee's eligibility year. In addition, there.... The Average Monthly Earnings PIA formula is used to compute a PIA for one of two reasons: either the... 20 Employees' Benefits 1 2011-04-01 2011-04-01 false PIA computation formulas. 225.3 Section 225.3...

  19. 20 CFR 340.7 - Deduction in computation of death benefit.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 1 2012-04-01 2012-04-01 false Deduction in computation of death benefit... UNEMPLOYMENT INSURANCE ACT RECOVERY OF BENEFITS § 340.7 Deduction in computation of death benefit. In computing... as benefits accrued to the individual but not paid at death. [57 FR 1379, Jan. 14, 1992] ...

  20. 20 CFR 340.7 - Deduction in computation of death benefit.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 1 2013-04-01 2012-04-01 true Deduction in computation of death benefit. 340... UNEMPLOYMENT INSURANCE ACT RECOVERY OF BENEFITS § 340.7 Deduction in computation of death benefit. In computing... as benefits accrued to the individual but not paid at death. [57 FR 1379, Jan. 14, 1992] ...

  1. 20 CFR 340.7 - Deduction in computation of death benefit.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 1 2011-04-01 2011-04-01 false Deduction in computation of death benefit... UNEMPLOYMENT INSURANCE ACT RECOVERY OF BENEFITS § 340.7 Deduction in computation of death benefit. In computing... as benefits accrued to the individual but not paid at death. [57 FR 1379, Jan. 14, 1992] ...

  2. 20 CFR 340.7 - Deduction in computation of death benefit.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 20 Employees' Benefits 1 2014-04-01 2012-04-01 true Deduction in computation of death benefit. 340... UNEMPLOYMENT INSURANCE ACT RECOVERY OF BENEFITS § 340.7 Deduction in computation of death benefit. In computing... as benefits accrued to the individual but not paid at death. [57 FR 1379, Jan. 14, 1992] ...

  3. A Novel Technique to Measure In Vivo Uterine Suspensory Ligament Stiffness

    PubMed Central

    Smith, Tovia M.; Luo, Jiajia; Hsu, Yvonne; Ashton-Miller, James A.; Delancey, John O.L.

    2013-01-01

    Objective To describe a new computer-controlled research apparatus for measuring in vivo uterine ligament force-displacement behavior and stiffness and to present pilot data in women with and without prolapse. Study Design Seventeen women with varying uterine support underwent testing in the operating room (OR) after anesthetic induction. A tripod-mounted computer-controlled linear servoactuator was used to quantify force-displacement behavior of the cervix and supporting ligaments. The servoactuator applied a caudally-directed force to a tenaculum at 4 mm/s velocity until the traction force reached 17.8N (4 lbs.). Cervix location on POP-Q in clinic, in the OR at rest, and with minimal force (<1.1N), and maximum force (17.8N) was recorded. Ligament “stiffness” between minimum and maximum force was calculated. Results The mean (SD) subject age was 54.5 (12.7) years, parity 2.9 (1.1), BMI 29.0 (4.3) kg/m2, and POP-Q point C −3.1 (3.9) cm. POP-Q point C was most strongly correlated with cervix location at maximum force (r=+0.68, p=.003) and at rest (r=+0.62, p=.009). Associations between cervix location at minimum force (r=+0.46, p=.059) and ligament stiffness (r= −0.44,p=.079) were not statistically significant. Cervix location in the OR with minimal traction lay below the lowest point found on POP-Q for 13 women. Conclusions POP-Q point C was strongly correlated with cervix location at rest and at maximum traction force; however only 19% of the variation in POP-Q point C location was explained by ligament stiffness. The cervix location in the OR at minimal traction lay below POP-Q point C value in ¾ of women. PMID:23747493

  4. An X-Ray Imaging Survey of Quasar Jets: The Complete Survey

    NASA Astrophysics Data System (ADS)

    Marshall, H. L.; Gelbord, J. M.; Worrall, D. M.; Birkinshaw, M.; Schwartz, D. A.; Jauncey, D. L.; Griffiths, G.; Murphy, D. W.; Lovell, J. E. J.; Perlman, E. S.; Godfrey, L.

    2018-03-01

    We present Chandra X-ray imaging of a flux-limited sample of flat spectrum radio-emitting quasars with jet-like structure. X-rays are detected from 59% of 56 jets. No counter-jets were detected. The core spectra are fitted by power-law spectra with a photon index Γ x , whose distribution is consistent with a normal distribution, with a mean of 1.61+0.04 ‑0.05 and dispersion of 0.15+0.04 ‑0.03. We show that the distribution of α rx , the spectral index between the X-ray and radio band jet fluxes, fits a Gaussian with a mean of 0.974 ± 0.012 and dispersion of 0.077 ± 0.008. We test the model in which kiloparsec-scale X-rays result from inverse Compton scattering of cosmic microwave background photons off the jet’s relativistic electrons (the IC-CMB model). In the IC-CMB model, a quantity Q computed from observed fluxes and the apparent size of the emission region depends on redshift as (1 + z)3+α . We fit Q ∝ (1 + z) a , finding a = 0.88 ± 0.90, and reject at 99.5% confidence the hypothesis that the average α rx depends on redshift in the manner expected in the IC-CMB model. This conclusion is mitigated by a lack of detailed knowledge of the emission region geometry, which requires deeper or higher resolution X-ray observations. Furthermore, if the IC-CMB model is valid for X-ray emission from kiloparsec-scale jets, then the jets must decelerate on average: bulk Lorentz factors should drop from about 15 to 2–3 between parsec and kiloparsec scales. Our results compound the problems that the IC-CMB model has in explaining the X-ray emission of kiloparsec-scale jets.

  5. AB119. Computer-aided facial recognition of Chinese individuals with 22q11.2 deletion-algorithm training using NIH atlas of human malformation syndromes from diverse population

    PubMed Central

    Mok, Gary Tsz Kin; Chung, Brian Hon-Yin

    2017-01-01

    Background 22q11.2 deletion syndrome (22q11.2DS) is a common genetic disorder with an estimated frequency of 1/4,000. It is a multi-systemic disorder with high phenotypic variability. Our previous work showed substantial under-diagnosis of 22q11.2DS as 1 in 10 adult patients with conotruncal defects were found to have 22q11.2DS. The National Institute of Health (NIH) has created an atlas of human malformation syndrome from diverse populations to provide an easy tool to assist clinician in diagnosing the syndromic across various populations. In this study, we seek to determine whether training the computer-aided facial recognition technology using images from ethnicity-matched patients from the NIH Atlas can improve the detection performance of this technology. Methods Clinical photographs of 16 Chinese subjects with molecularly confirmed 22q11.2DS, from the NIH atlas and its related publication were used for training the facial recognition technology. The system automatically localizes hundreds of facial fiducial points and takes measurements. The final classification is based on these measurements, as well as an estimated probability of subjects having 22q11.2DS based on the entire facial image. Clinical photographs of 7 patients with molecularly confirmed 22q11.2DS were obtained with informed consent and used for testing the performance in recognizing facial profiles of the Chinese subjects before and after training. Results All 7 test cases were improved in ranking and scoring after the software training. In 4 cases, 22q11.2DS did not appear as one possible syndrome match before the training; however, it appeared within the first 10 syndrome matches after training. Conclusions The present pilot data shows that this technology can be trained to recognize patients with 22q11.2DS. It also highlights the need to collect clinical photographs of patients from diverse populations to be used as resources for training the software which can lead to improvement of the performance of computer-aided facial recognition technology.

  6. 26 CFR 1.1402(a)-3 - Special rules for computing net earnings from self-employment.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 12 2010-04-01 2010-04-01 false Special rules for computing net earnings from....1402(a)-3 Special rules for computing net earnings from self-employment. For the purpose of computing... by a partnership of which he is a member shall be computed in accordance with the special rules set...

  7. Geographic List of Prime Contract Awards. Oct 91 - Sep 92. FY92. (Nanticoke Maryland - Garden City Michigan)

    DTIC Science & Technology

    1993-01-01

    N4 ._ K MWL0.I- It 0o 00 10 0 0 00-40000 -04 0 (nK 00M0 a >- 22 Z 22222 z zzz z R nowo u 0 cow0 Q 4040040404 0 40404 40 If I001- a 04C 0ɜ 0 0 04 04.4...W40ld 00000I -4-000 C> 0 C000o1.170 1-00 -4 X I ( 1 010-4 1 0):C 0)~ Y- 40oO -4(0(0 oxZZ-j 0000 0-I -f) 347 M. Hf 4 5 00-4 if0)0 04 4000 04V)(󈨋) (7< <) 4...00000000’cJa 40C0,ln)00 Af I M02000 it vlwt"A4 (0 NOWO -t4--4-No )0) )NN0)I)1l00D0-40-I)0 -40D-𔃺C’.I002C-4 of I M0C000 ofiil -f 00 nn)U0f4 ~ aiN)noo~0)t

  8. 26 CFR 1.5000A-4 - Computation of shared responsibility payment.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 26 Internal Revenue 13 2014-04-01 2014-04-01 false Computation of shared responsibility payment. 1.5000A-4 Section 1.5000A-4 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY... individual was born. For example, an individual born on March 1, 1999, attains the age of 18 on March 1, 2017...

  9. Optical back propagation for fiber optic networks with hybrid EDFA Raman amplification.

    PubMed

    Liang, Xiaojun; Kumar, Shiva

    2017-03-06

    We have investigated an optical back propagation (OBP) method to compensate for propagation impairments in fiber optic networks with lumped Erbium doped fiber amplifier (EDFA) and/or distributed Raman amplification. An OBP module consists of an optical phase conjugator (OPC), optical amplifiers and dispersion varying fibers (DVFs). We derived a semi-analytical expression that calculates the dispersion profile of DVF. The OBP module acts as a nonlinear filter that fully compensates for the nonlinear distortions due to signal propagation in a transmission fiber, and is applicable for fiber optic networks with reconfigurable optical add-drop multiplexers (ROADMs). We studied a wavelength division multiplexing (WDM) network with 3000 km transmission distance and 64-quadrature amplitude modulation (QAM) modulation. OBP brings 5.8 dB, 5.9 dB and 6.1 dB Q-factor gains over linear compensation for systems with full EDFA amplification, hybrid EDFA/Raman amplification, and full Raman amplification, respectively. In contrast, digital back propagation (DBP) or OPC-only systems provide only 0.8 ~ 1.5 dB Q-factor gains.

  10. Dimensionality Reduction in Big Data with Nonnegative Matrix Factorization

    DTIC Science & Technology

    2017-06-20

    appli- cations of data mining, signal processing , computer vision, bioinformatics, etc. Fun- damentally, NMF has two main purposes. First, it reduces...shape of the function becomes more spherical because ∂ 2g ∂y2i = 1, ∀i, and g(y) is convex. This part aims to make the post- processing parts more...maxStop = 0 for each thread of computation */; 3 /*Re-scaling variables*/; 4 Q = H√ diag(H)diag(H)T ; q = h√ diag(H) ; 5 /*Solving NQP: minimizingf(x

  11. Prime Contract Awards by State or Country, Place and Contractor. Part 13 (New London, Ohio - Westerly, Rhode Island), FY1991

    DTIC Science & Technology

    1991-01-01

    u I (04q N -iLifLn-i0)00 .- Cl) -- If .’t- -- 400 r1I- -4-. M(𔄁 . "I XN 1,- 1I to I (04e 11 1f4.-400𔃾 in -f o~n InJ N L0304 toN 0n (no U O 4 vUN 0...o CN M C) a) "൒ -’ 14"to0" C>(W P 00(W0t- 00m 0- --4 C~nC’ r-- KooN 400 0 -4-4 a0(D0)( w 4(1(0 -4 * 4m( 0-4 m0000000CC>C0 -4"K 4OI 41 CC D>)- 000C

  12. Application of the dynamically allocated virtual clustering management system to emulated tactical network experimentation

    NASA Astrophysics Data System (ADS)

    Marcus, Kelvin

    2014-06-01

    The U.S Army Research Laboratory (ARL) has built a "Network Science Research Lab" to support research that aims to improve their ability to analyze, predict, design, and govern complex systems that interweave the social/cognitive, information, and communication network genres. Researchers at ARL and the Network Science Collaborative Technology Alliance (NS-CTA), a collaborative research alliance funded by ARL, conducted experimentation to determine if automated network monitoring tools and task-aware agents deployed within an emulated tactical wireless network could potentially increase the retrieval of relevant data from heterogeneous distributed information nodes. ARL and NS-CTA required the capability to perform this experimentation over clusters of heterogeneous nodes with emulated wireless tactical networks where each node could contain different operating systems, application sets, and physical hardware attributes. Researchers utilized the Dynamically Allocated Virtual Clustering Management System (DAVC) to address each of the infrastructure support requirements necessary in conducting their experimentation. The DAVC is an experimentation infrastructure that provides the means to dynamically create, deploy, and manage virtual clusters of heterogeneous nodes within a cloud computing environment based upon resource utilization such as CPU load, available RAM and hard disk space. The DAVC uses 802.1Q Virtual LANs (VLANs) to prevent experimentation crosstalk and to allow for complex private networks. Clusters created by the DAVC system can be utilized for software development, experimentation, and integration with existing hardware and software. The goal of this paper is to explore how ARL and the NS-CTA leveraged the DAVC to create, deploy and manage multiple experimentation clusters to support their experimentation goals.

  13. CD Applications Study.

    DTIC Science & Technology

    1982-04-01

    Vo2 +2V [,G -VFB1 + ox o G FB 2 A2L (2 2 Q 2V Cox 0 o[ - V.FB ACoxJ J and V V -V +G G FB AC ox V q e vN/C 2 0 s oA ox Qs = total channel charge 18 A...0.57 IC 0 /2 -30 0.4 .57 a1=0.40 6 0.3- -90 0.40 0.30 0.309 0.2 -- 120 -150 0.1 -130 0 0 100 200 300 400 500 1 1SIG Hz Figure 25. First-Order...problem with filter circuitry, it is the limiting character- istic for A/D applications. Surface state annealing treatments can be incorporated in the

  14. Anthropometric Source Book. Volume 2: A Handbook of Anthropometric Data

    DTIC Science & Technology

    1978-07-01

    a.mw* % A W " " -I4 0-4DB~M’a~P Z.=22014 MO ZW=O𔃾WW4L" 0 "OBCOO&WWOWWBAB z z 34 " 14 0-44 BBP o z:.~Bwz 1 Wz0 V1O󈧵 j =P.’)ON- 01-0 e e o 0 t...4 c: P) POP~f pol IV)~) ~ P)V) t) PFrW)WW))m x dCY4 0- -a I.- - 0 ~ ItTt t: 1 1 % t’Q.4 O’*t%if! N D Dc ! 4 1Dff~ ffa ul In .4 NV4 W v4 q4v4 v4 NUM

  15. Tricriticality in the q-neighbor Ising model on a partially duplex clique.

    PubMed

    Chmiel, Anna; Sienkiewicz, Julian; Sznajd-Weron, Katarzyna

    2017-12-01

    We analyze a modified kinetic Ising model, a so-called q-neighbor Ising model, with Metropolis dynamics [Phys. Rev. E 92, 052105 (2015)PLEEE81539-375510.1103/PhysRevE.92.052105] on a duplex clique and a partially duplex clique. In the q-neighbor Ising model each spin interacts only with q spins randomly chosen from its whole neighborhood. In the case of a duplex clique the change of a spin is allowed only if both levels simultaneously induce this change. Due to the mean-field-like nature of the model we are able to derive the analytic form of transition probabilities and solve the corresponding master equation. The existence of the second level changes dramatically the character of the phase transition. In the case of the monoplex clique, the q-neighbor Ising model exhibits a continuous phase transition for q=3, discontinuous phase transition for q≥4, and for q=1 and q=2 the phase transition is not observed. On the other hand, in the case of the duplex clique continuous phase transitions are observed for all values of q, even for q=1 and q=2. Subsequently we introduce a partially duplex clique, parametrized by r∈[0,1], which allows us to tune the network from monoplex (r=0) to duplex (r=1). Such a generalized topology, in which a fraction r of all nodes appear on both levels, allows us to obtain the critical value of r=r^{*}(q) at which a tricriticality (switch from continuous to discontinuous phase transition) appears.

  16. Artificial Neural Networks applied to estimate permeability, porosity and intrinsic attenuation using seismic attributes and well-log data

    NASA Astrophysics Data System (ADS)

    Iturrarán-Viveros, Ursula; Parra, Jorge O.

    2014-08-01

    Permeability and porosity are two fundamental reservoir properties which relate to the amount of fluid contained in a reservoir and its ability to flow. The intrinsic attenuation is another important parameter since it is related to porosity, permeability, oil and gas saturation and these parameters significantly affect the seismic signature of a reservoir. We apply Artificial Neural Network (ANN) models to predict permeability (k) and porosity (ϕ) for a carbonate aquifer in southeastern Florida and to predict intrinsic attenuation (1/Q) for a sand-shale oil reservoir in northeast Texas. In this study, the Gamma test (a revolutionary estimator of the noise in a data set) has been used as a mathematically non-parametric nonlinear smooth modeling tool to choose the best input combination of seismic attributes to estimate k and ϕ, and the best combination of well-logs to estimate 1/Q. This saves time during the construction and training of ANN models and also sets a lower bound for the mean squared error to prevent over-training. The Neural Network method successfully delineates a highly permeable zone that corresponds to a high water production in the aquifer. The Gamma test found nonlinear relations that were not visible to linear regression allowing us to generalize the ANN estimations of k, ϕ and 1/Q for their respective sets of patterns that were not used during the learning phase.

  17. High Performance Double-null Plasma Operation Under Radiating Divertor Conditions

    NASA Astrophysics Data System (ADS)

    Petrie, T. W.; Osborne, T.; Leonard, A. W.; Luce, T. C.; Petty, C. C.; Fenstermacher, M. E.; Lasnier, C. J.; Turco, F.; Watkins, J. G.

    2017-10-01

    We report on heat flux reduction experiments in which deuterium/neon- or deuterium/argon-based radiating mantle/divertor approaches were applied to high performance double-null (DN) plasmas (H98 1.4-1.7,βN 4 , q 95 6) with a combined neutral beam and ECH power input PIN 15 MW. When the radial location of the ECH deposition is close to the magnetic axis (e.g., ρ <=0.20), the radial profiles of both injected and intrinsic impurities are flat to somewhat hollow. For deposition farther out (e.g., ρ=0.45), the impurity profiles are highly peaked on axis, which would make high performance DN operation with impurity injection more problematical. Comparison of neon with argon `seeding' with respect to core dilution, energy confinement, and heat flux reduction under these conditions favors argon. Conditions that lead to an improved τE as predicted previously from ELITE code analysis, i.e., very high PIN, proximity to magnetic balance, and higher q95, are largely consistent with this data. Work was supported by the US DOE under DE-FC02-04ER54698, DE-AC52-07NA27344, DE-FG02-04ER54761, and DE-AC04-94AL85000.

  18. Effects of epidemic threshold definition on disease spread statistics

    NASA Astrophysics Data System (ADS)

    Lagorio, C.; Migueles, M. V.; Braunstein, L. A.; López, E.; Macri, P. A.

    2009-03-01

    We study the statistical properties of SIR epidemics in random networks, when an epidemic is defined as only those SIR propagations that reach or exceed a minimum size sc. Using percolation theory to calculate the average fractional size of an epidemic, we find that the strength of the spanning link percolation cluster P∞ is an upper bound to . For small values of sc, P∞ is no longer a good approximation, and the average fractional size has to be computed directly. We find that the choice of sc is generally (but not always) guided by the network structure and the value of T of the disease in question. If the goal is to always obtain P∞ as the average epidemic size, one should choose sc to be the typical size of the largest percolation cluster at the critical percolation threshold for the transmissibility. We also study Q, the probability that an SIR propagation reaches the epidemic mass sc, and find that it is well characterized by percolation theory. We apply our results to real networks (DIMES and Tracerouter) to measure the consequences of the choice sc on predictions of average outcome sizes of computer failure epidemics.

  19. Computational systems biology analysis of biomarkers in lung cancer; unravelling genomic regions which frequently encode biomarkers, enriched pathways, and new candidates.

    PubMed

    Alanazi, Ibrahim O; AlYahya, Sami A; Ebrahimie, Esmaeil; Mohammadi-Dehcheshmeh, Manijeh

    2018-06-15

    Exponentially growing scientific knowledge in scientific publications has resulted in the emergence of a new interdisciplinary science of literature mining. In text mining, the machine reads the published literature and transfers the discovered knowledge to mathematical-like formulas. In an integrative approach in this study, we used text mining in combination with network discovery, pathway analysis, and enrichment analysis of genomic regions for better understanding of biomarkers in lung cancer. Particular attention was paid to non-coding biomarkers. In total, 60 MicroRNA biomarkers were reported for lung cancer, including some prognostic biomarkers. MIR21, MIR155, MALAT1, and MIR31 were the top non-coding RNA biomarkers of lung cancer. Text mining identified 447 proteins which have been studied as biomarkers in lung cancer. EGFR (receptor), TP53 (transcription factor), KRAS, CDKN2A, ENO2, KRT19, RASSF1, GRP (ligand), SHOX2 (transcription factor), and ERBB2 (receptor) were the most studied proteins. Within small molecules, thymosin-a1, oestrogen, and 8-OHdG have received more attention. We found some chromosomal bands, such as 7q32.2, 18q12.1, 6p12, 11p15.5, and 3p21.3 that are highly involved in deriving lung cancer biomarkers. Copyright © 2018 Elsevier B.V. All rights reserved.

  20. OpenFlow Extensions for Programmable Quantum Networks

    DTIC Science & Technology

    2017-06-19

    Extensions for Programmable Quantum Networks by Venkat Dasari, Nikolai Snow, and Billy Geerhart Computational and Information Sciences Directorate...distribution is unlimited. 1 1. Introduction Quantum networks and quantum computing have been receiving a surge of interest recently.1–3 However, there has...communicate using entangled particles and perform calculations using quantum logic gates. Additionally, quantum computing uses a quantum bit (qubit

  1. 20 CFR 71.2 - Computation of benefits.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 20 Employees' Benefits 1 2012-04-01 2012-04-01 false Computation of benefits. 71.2 Section 71.2 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF LABOR COMPENSATION FOR INJURY... JAPANESE GOVERNMENT GENERAL PROVISIONS § 71.2 Computation of benefits. (a) For the purpose of determining...

  2. 20 CFR 71.2 - Computation of benefits.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 1 2011-04-01 2011-04-01 false Computation of benefits. 71.2 Section 71.2 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF LABOR COMPENSATION FOR INJURY... JAPANESE GOVERNMENT GENERAL PROVISIONS § 71.2 Computation of benefits. (a) For the purpose of determining...

  3. 20 CFR 71.2 - Computation of benefits.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 20 Employees' Benefits 1 2013-04-01 2012-04-01 true Computation of benefits. 71.2 Section 71.2 Employees' Benefits OFFICE OF WORKERS' COMPENSATION PROGRAMS, DEPARTMENT OF LABOR COMPENSATION FOR INJURY... JAPANESE GOVERNMENT GENERAL PROVISIONS § 71.2 Computation of benefits. (a) For the purpose of determining...

  4. Design, Simulation, and Experimental Verification of a Computer Model and Enhanced Position Estimator for the NPS AUV II

    DTIC Science & Technology

    1991-12-01

    NDRB REAL NPDOT, NRDOT, NPQ, NQR , NVDOT, NP, NR, NVQ, NWP,NWR, NV,NVW, NDRS REAL MM(6,6),INDX(100) DIMENSION X(15),BR(15),HH(15),VECH1(15),VECH2(15...MASS*YG*W*Q+NPQ*P*Q+’ & NQR *Q*R+NP*U*P+NR*U*R+NVQ*V*Q+NWP*W*P+NWP*W*R+NV*U*V+ NV*VWY DR+ DB(XG*WEIGHT-XB*BOY) * &COS(THETA) *SIN(PHI)+(YG*WEIGHT-YB*BOY

  5. Demonstration of Improved Software Support Labor Estimation For Air Force Operational Flight Programs Through Functional Orientation

    DTIC Science & Technology

    1993-12-01

    single, fully developed, tesied , documented, and supportable computer instruction set replicated in sufficient quantities and delivered to the...ThesisRec.ACTKDSI " ExpOnLy) * BCT SUlff = SulM4Q + ThesisRec.ACTEFFORT * TempQ C.56 SuiQ2 x SumZ + TempQ * TeMA ’CatcuLate sum for Coefficient and Exponent...4 - Sacramento ALC Block Change Process D.13 MIL-HDBK-347 Block Change Process Level 1 pivobernVctuer PMS De "wy ReprtProcess Packgep Level 2

  6. An online network tool for quality information to answer questions about occupational safety and health: usability and applicability.

    PubMed

    Rhebergen, Martijn D F; Hulshof, Carel T J; Lenderink, Annet F; van Dijk, Frank J H

    2010-10-22

    Common information facilities do not always provide the quality information needed to answer questions on health or health-related issues, such as Occupational Safety and Health (OSH) matters. Barriers may be the accessibility, quantity and readability of information. Online Question & Answer (Q&A) network tools, which link questioners directly to experts can overcome some of these barriers. When designing and testing online tools, assessing the usability and applicability is essential. Therefore, the purpose of this study is to assess the usability and applicability of a new online Q&A network tool for answers on OSH questions. We applied a cross-sectional usability test design. Eight occupational health experts and twelve potential questioners from the working population (workers) were purposively selected to include a variety of computer- and internet-experiences. During the test, participants were first observed while executing eight tasks that entailed important features of the tool. In addition, they were interviewed. Through task observations and interviews we assessed applicability, usability (effectiveness, efficiency and satisfaction) and facilitators and barriers in use. Most features were usable, though several could be improved. Most tasks were executed effectively. Some tasks, for example searching stored questions in categories, were not executed efficiently and participants were less satisfied with the corresponding features. Participants' recommendations led to improvements. The tool was found mostly applicable for additional information, to observe new OSH trends and to improve contact between OSH experts and workers. Hosting and support by a trustworthy professional organization, effective implementation campaigns, timely answering and anonymity were seen as important use requirements. This network tool is a promising new strategy for offering company workers high quality information to answer OSH questions. Q&A network tools can be an addition to existing information facilities in the field of OSH, but also to other healthcare fields struggling with how to answer questions from people in practice with high quality information. In the near future, we will focus on the use of the tool and its effects on information and knowledge dissemination.

  7. 26 CFR 1.611-4 - Depletion as a factor in computing earnings and profits for dividend purposes.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 26 Internal Revenue 7 2011-04-01 2009-04-01 true Depletion as a factor in computing earnings and profits for dividend purposes. 1.611-4 Section 1.611-4 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Natural Resources § 1...

  8. 26 CFR 1.611-4 - Depletion as a factor in computing earnings and profits for dividend purposes.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 7 2010-04-01 2010-04-01 true Depletion as a factor in computing earnings and profits for dividend purposes. 1.611-4 Section 1.611-4 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Natural Resources § 1...

  9. Electrical Resistivity of Ten Selected Binary Alloy Systems.

    DTIC Science & Technology

    1981-04-01

    100 m 2 L q2 2 J 4m v 2 1 ......... 13 I Here e , m, and v are the electronic charge, mass, and velocity, q is the screening parameter, and I is the...potentiometer method E Eddy current decay method wpik* -7 25 P Van der Pauw method R Rotating magnetic field method V Voltmeter and ammeter direct...r:~ 0; tz 0 hi~~ 0*~ . 0 . 6 0 M 0 0 % -0 0 e o C M -" I- I n WT 8 L a .44 44 -44 4 %. -~~ 0 0 0 0 U0. ii S 4. 0c .2 s , Q t 04 INN ) nW V W 33

  10. Analysis of coined quantum walks with renormalization

    NASA Astrophysics Data System (ADS)

    Boettcher, Stefan; Li, Shanshan

    2018-01-01

    We introduce a framework to analyze quantum algorithms with the renormalization group (RG). To this end, we present a detailed analysis of the real-space RG for discrete-time quantum walks on fractal networks and show how deep insights into the analytic structure as well as generic results about the long-time behavior can be extracted. The RG flow for such a walk on a dual Sierpinski gasket and a Migdal-Kadanoff hierarchical network is obtained explicitly from elementary algebraic manipulations, after transforming the unitary evolution equation into Laplace space. Unlike for classical random walks, we find that the long-time asymptotics for the quantum walk requires consideration of a diverging number of Laplace poles, which we demonstrate exactly for the closed-form solution available for the walk on a one-dimensional loop. In particular, we calculate the probability of the walk to overlap with its starting position, which oscillates with a period that scales as NdwQ/df with system size N . While the largest Jacobian eigenvalue λ1 of the RG flow merely reproduces the fractal dimension, df=log2λ1 , the asymptotic analysis shows that the second Jacobian eigenvalue λ2 becomes essential to determine the dimension of the quantum walk via dwQ=log2√{λ1λ2 } . We trace this fact to delicate cancellations caused by unitarity. We obtain identical relations for other networks, although the details of the RG analysis may exhibit surprisingly distinct features. Thus, our conclusions—which trivially reproduce those for regular lattices with translational invariance with df=d and dwQ=1 —appear to be quite general and likely apply to networks beyond those studied here.

  11. Combining Neural Networks with Existing Methods to Estimate 1 in 100-Year Flood Event Magnitudes

    NASA Astrophysics Data System (ADS)

    Newson, A.; See, L.

    2005-12-01

    Over the last fifteen years artificial neural networks (ANN) have been shown to be advantageous for the solution of many hydrological modelling problems. The use of ANNs for flood magnitude estimation in ungauged catchments, however, is a relatively new and under researched area. In this paper ANNs are used to make estimates of the magnitude of the 100-year flood event (Q100) for a number of ungauged catchments. The data used in this study were provided by the Centre for Ecology and Hydrology's Flood Estimation Handbook (FEH), which contains information on catchments across the UK. Sixteen catchment descriptors for 719 catchments were used to train an ANN, which was split into a training, validation and test data set. The goodness-of-fit statistics on the test data set indicated good model performance, with an r-squared value of 0.8 and a coefficient of efficiency of 79 percent. Data for twelve ungauged catchments were then put through the trained ANN to produce estimates of Q100. Two other accepted methodologies were also employed: the FEH statistical method and the FSR (Flood Studies Report) design storm technique, both of which are used to produce flood frequency estimates. The advantage of developing an ANN model is that it provides a third figure to aid a hydrologist in making an accurate estimate. For six of the twelve catchments, there was a relatively low spread between estimates. In these instances, an estimate of Q100 could be made with a fair degree of certainty. Of the remaining six catchments, three had areas greater than 1000km2, which means the FSR design storm estimate cannot be used. Armed with the ANN model and the FEH statistical method the hydrologist still has two possible estimates to consider. For these three catchments, the estimates were also fairly similar, providing additional confidence to the estimation. In summary, the findings of this study have shown that an accurate estimation of Q100 can be made using the catchment descriptors of an ungauged catchment as inputs to an ANN. It also demonstrated how the ANN Q100 estimates can be used in conjunction with a number of other estimates in order to provide a more accurate and confident estimate of Q100 at an ungauged catchment. This clearly exploits the strengths of existing methods in combination with the latest soft computing tools.

  12. Non-conforming finite-element formulation for cardiac electrophysiology: an effective approach to reduce the computation time of heart simulations without compromising accuracy

    NASA Astrophysics Data System (ADS)

    Hurtado, Daniel E.; Rojas, Guillermo

    2018-04-01

    Computer simulations constitute a powerful tool for studying the electrical activity of the human heart, but computational effort remains prohibitively high. In order to recover accurate conduction velocities and wavefront shapes, the mesh size in linear element (Q1) formulations cannot exceed 0.1 mm. Here we propose a novel non-conforming finite-element formulation for the non-linear cardiac electrophysiology problem that results in accurate wavefront shapes and lower mesh-dependance in the conduction velocity, while retaining the same number of global degrees of freedom as Q1 formulations. As a result, coarser discretizations of cardiac domains can be employed in simulations without significant loss of accuracy, thus reducing the overall computational effort. We demonstrate the applicability of our formulation in biventricular simulations using a coarse mesh size of ˜ 1 mm, and show that the activation wave pattern closely follows that obtained in fine-mesh simulations at a fraction of the computation time, thus improving the accuracy-efficiency trade-off of cardiac simulations.

  13. Modifiers and mechanisms of multi-system polyglutamine neurodegenerative disorders: lessons from fly models.

    PubMed

    Mallik, Moushami; Lakhotia, Subhash C

    2010-12-01

    Polyglutamine (polyQ) diseases, resulting from a dynamic expansion of glutamine repeats in a polypeptide, are a class of genetically inherited late onset neurodegenerative disorders which, despite expression of the mutated gene widely in brain and other tissues, affect defined subpopulations of neurons in a disease-specific manner. We briefly review the different polyQ-expansion-induced neurodegenerative disorders and the advantages of modelling them in Drosophila. Studies using the fly models have successfully identified a variety of genetic modifiers and have helped in understanding some of the molecular events that follow expression of the abnormal polyQ proteins. Expression of the mutant polyQ proteins causes, as a consequence of intra-cellular and inter-cellular networking, mis-regulation at multiple steps like transcriptional and posttranscriptional regulations, cell signalling, protein quality control systems (protein folding and degradation networks), axonal transport machinery etc., in the sensitive neurons, resulting ultimately in their death. The diversity of genetic modifiers of polyQ toxicity identified through extensive genetic screens in fly and other models clearly reflects a complex network effect of the presence of the mutated protein. Such network effects pose a major challenge for therapeutic applications.

  14. Mitochondria-Targeted Antioxidant Mitoquinone Reduces Cisplatin-Induced Ototoxicity in Guinea Pigs.

    PubMed

    Tate, Alan D; Antonelli, Patrick J; Hannabass, Kyle R; Dirain, Carolyn O

    2017-03-01

    Objective To determine if mitoquinone (MitoQ) attenuates cisplatin-induced hearing loss in guinea pigs. Study Design Prospective and controlled animal study. Setting Academic, tertiary medical center. Subjects and Methods Guinea pigs were injected subcutaneously with either 5 mg/kg MitoQ (n = 9) or normal saline (control, n = 9) for 7 days and 1 hour before receiving a single dose of 10 mg/kg cisplatin. Auditory brainstem response thresholds were measured before MitoQ or saline administration and 3 to 4 days after cisplatin administration. Results Auditory brainstem response threshold shifts after cisplatin treatment were smaller by 28 to 47 dB in guinea pigs injected with MitoQ compared with those in the control group at all tested frequencies (4, 8, 16, and 24 kHz, P = .0002 to .04). Scanning electron microscopy of cochlear hair cells showed less outer hair cell loss and damage in the MitoQ group. Conclusion MitoQ reduced cisplatin-induced hearing loss in guinea pigs. MitoQ appears worthy of further investigation as a means of preventing cisplatin ototoxicity in humans.

  15. Prime Contract Awards Alphabetically by Contractor, by State or Country, and Place, FY 85. Part 20 (Tokkey Uluslarararasi Naklejet - Video & Sealing Inc).

    DTIC Science & Technology

    1985-01-01

    ON 0- -1r)- 04 N00O 1(0 1-4 -#.-44 nO P4I 4 N 04 0 4 -1-4C M’ 281 0 11. u. cc =ta0 ’ 4 m 1004 ANl.(( 0 -O -t3- 0 UN W 0( I ce I- .40 -4 -4 1-4 14 0000...000000 00 00 000 4- I IO NCVI 1 00 I J (SN - -l4 ICNCJ .. to I ZWI In I I xo.( -1i ouooooooooooooooooooooooooooooooooooooooooooooo W -04 0 to N N990= = ao...Y C)N A 0 -4 04 - 4 4- .4 0A l -00 , 4c (00 I gn S ) 01- 1-- U)-0cccn- 0n 40n N NN -4 N (INN C, in4Uan- z CD-q z zwi I (00j I C 0) -z -C’ NV 00ltet

  16. Collective relaxation dynamics of small-world networks

    NASA Astrophysics Data System (ADS)

    Grabow, Carsten; Grosskinsky, Stefan; Kurths, Jürgen; Timme, Marc

    2015-05-01

    Complex networks exhibit a wide range of collective dynamic phenomena, including synchronization, diffusion, relaxation, and coordination processes. Their asymptotic dynamics is generically characterized by the local Jacobian, graph Laplacian, or a similar linear operator. The structure of networks with regular, small-world, and random connectivities are reasonably well understood, but their collective dynamical properties remain largely unknown. Here we present a two-stage mean-field theory to derive analytic expressions for network spectra. A single formula covers the spectrum from regular via small-world to strongly randomized topologies in Watts-Strogatz networks, explaining the simultaneous dependencies on network size N , average degree k , and topological randomness q . We present simplified analytic predictions for the second-largest and smallest eigenvalue, and numerical checks confirm our theoretical predictions for zero, small, and moderate topological randomness q , including the entire small-world regime. For large q of the order of one, we apply standard random matrix theory, thereby overarching the full range from regular to randomized network topologies. These results may contribute to our analytic and mechanistic understanding of collective relaxation phenomena of network dynamical systems.

  17. Collective relaxation dynamics of small-world networks.

    PubMed

    Grabow, Carsten; Grosskinsky, Stefan; Kurths, Jürgen; Timme, Marc

    2015-05-01

    Complex networks exhibit a wide range of collective dynamic phenomena, including synchronization, diffusion, relaxation, and coordination processes. Their asymptotic dynamics is generically characterized by the local Jacobian, graph Laplacian, or a similar linear operator. The structure of networks with regular, small-world, and random connectivities are reasonably well understood, but their collective dynamical properties remain largely unknown. Here we present a two-stage mean-field theory to derive analytic expressions for network spectra. A single formula covers the spectrum from regular via small-world to strongly randomized topologies in Watts-Strogatz networks, explaining the simultaneous dependencies on network size N, average degree k, and topological randomness q. We present simplified analytic predictions for the second-largest and smallest eigenvalue, and numerical checks confirm our theoretical predictions for zero, small, and moderate topological randomness q, including the entire small-world regime. For large q of the order of one, we apply standard random matrix theory, thereby overarching the full range from regular to randomized network topologies. These results may contribute to our analytic and mechanistic understanding of collective relaxation phenomena of network dynamical systems.

  18. The paradoxical evolution of runoff in the pastoral Sahel: analysis of the hydrological changes over the Agoufou watershed (Mali) using the KINEROS-2 model

    NASA Astrophysics Data System (ADS)

    Gal, Laetitia; Grippa, Manuela; Hiernaux, Pierre; Pons, Léa; Kergoat, Laurent

    2017-09-01

    In recent decades, the Sahel has witnessed a paradoxical increase in surface water despite a general precipitation decline. This phenomenon, commonly referred to as the Sahelian paradox, is not completely understood yet. The role of cropland expansion due to the increasing food demand by a growing population has been often put forward to explain this situation for the cultivated Sahel. However, this hypothesis does not hold in pastoral areas where the same phenomenon is observed. Several other processes, such as the degradation of natural vegetation following the major droughts of the 1970s and the 1980s, the development of crusted topsoils, the intensification of the rainfall regime and the development of the drainage network, have been suggested to account for this situation. In this paper, a modeling approach is proposed to explore, quantify and rank different processes that could be at play in pastoral Sahel. The kinematic runoff and erosion model (KINEROS-2) is applied to the Agoufou watershed (245 km2), in the Gourma region in Mali, which underwent a significant increase of surface runoff during the last 60 years. Two periods are simulated, the past case (1960-1975) preceding the Sahelian drought and the present case (2000-2015). Surface hydrology and land cover characteristics for these two periods are derived by the analysis of aerial photographs, available in 1956, and high-resolution remote sensing images in 2011. The major changes identified are (1) a partial crusting of isolated dunes, (2) an increase of drainage network density, (3) a marked decrease in vegetation with the nonrecovery of tiger bush and vegetation growing on shallow sandy soils, and (4) important changes in soil properties with the apparition of impervious soils instead of shallow sandy soil. The KINEROS-2 model was parameterized to simulate these changes in combination or independently. The results obtained by this model display a significant increase in annual discharge between the past and the present case (p value < 0.001), which is consistent with observations, despite a slight overestimation of the past discharge. Mean annual discharges are estimated at 0.51 × 106 m3 (2.1 mm yr-1) and 3.29 × 106 m3 (13.4 mm yr-1) for past and present, respectively. Changes in soil properties and vegetation cover (tiger bush thickets and grassland on shallow sandy soil) are found to be the main factors causing this increase of simulated runoff, with the drainage network development contributing to a lesser extent but with a positive feedback. These results shed a new light on the Sahelian paradox phenomenon in the absence of land use change and call for further tests in other areas and/or with other models. The synergetic processes highlighted here could play a role in other Sahelian watersheds where runoff increase has been also observed.

  19. Issues in Adaptive Planning

    DTIC Science & Technology

    1986-06-30

    approach to the application of theorem proving to problem solving, Aritificial Intelligence 2 (1Q71), 18Q- 208. 4. Fikes, R., Hart, P. and Nilsson, N...by emphasizing the structure of knowledge. 1.2. Planning Literature The earliest work in planning in Artificial Intelligence grew out of the work on...References 1. Newell, A., Artificial Intelligence and the concept of mind, in Computer models of thought and language, Schank, R. and Colby, K. (editor

  20. Prognostic performance of Emergency Severity Index (ESI) combined with qSOFA score.

    PubMed

    Kwak, Hyeongkyu; Suh, Gil Joon; Kim, Taegyun; Kwon, Woon Yong; Kim, Kyung Su; Jung, Yoon Sun; Ko, Jung-In; Shin, So Mi

    2018-01-31

    We conducted this study to investigate whether ESI combined with qSOFA score (ESI+qSOFA) predicts hospital outcome better than ESI alone in the emergency department (ED). This was a retrospective study for patients aged over 15years who visited an ED of a tertiary referral hospital from January 1st, 2015 to December 31st, 2015. We calculated and compared predictive performances of ESI alone and ESI+qSOFA for prespecified outcomes. The primary outcome was hospital mortality, and the secondary outcome was composite outcome of in-hospital mortality and ICU admission. We calculated in-hospital mortality rates by positive qSOFA in each subgroup divided according to ESI levels (1, 2, 3, 4+5). 43,748 patients were enrolled. The area under receiver-operating characteristics curves were higher in ESI+qSOFA than in ESI alone for both mortality and composite outcome (0.786 vs. 0.777, P<.001 for mortality; 0.778 vs. 0.774, P<.001 for composite outcome). In each subgroup divided by ESI levels, patients with positive qSOFA had significantly higher in-hospital mortality rate compared to those with negative qSOFA (20.4% vs. 14.7%, P=.117 in ESI level 1 subgroup; 11.3% vs. 2.7%, P=.001 in ESI level 2 subgroup; 2.3% vs. 0.4%, P<.001 in ESI level 3 subgroup; 0.0% vs. 0.0% in ESI level 4 or 5 subgroup). The prognostic performance of ESI+qSOFA for in-hospital mortality was significantly higher than that of ESI alone. Within each subgroup, patients with positive qSOFA had higher in-hospital mortality compared to those with negative qSOFA. Copyright © 2018 Elsevier Inc. All rights reserved.

  1. 26 CFR 1.1402(a)-14 - Options available to farmers in computing net earnings from self-employment for taxable years...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 12 2010-04-01 2010-04-01 false Options available to farmers in computing net earnings from self-employment for taxable years ending after 1954 and before December 31, 1956. 1.1402(a... available to farmers in computing net earnings from self-employment for taxable years ending after 1954 and...

  2. All Prime Contract Awards by State or Country, Place and Contractor. Part 7. (Aiea, Hawaii-Zion, Illinois)

    DTIC Science & Technology

    1989-01-01

    000 oao 0000 ’ 0 10 1 a I 0> I 01300011N 1 in 21 14-4 4140 (D 0 0 N1 -4 U) C1) (n N W I U)rK>U 11 0-4 -44-4-4 q-4 0-4-4-4 0.4 -4-4 0.-I 44O N N N in...4 if4-00 )r )(O c 00 -4 00 NO 0M 04 ,P-4 (4M (07) (0 r- on 1,-4 144(I0M4 if4-4 ."(-10 t VI = 141 Mx 00 Ni 20 4441 00 M 1 V 00 N 00 < 4140 ) I(0-4l if 4...00 4 44 It -0440 M 0 100 0 100 I0 (10 000000 140000 4140 MOO w- SI - x M fit0 mI M0 -40 1-400 -4 I -0 .n Z-400 0 0 -40 󈧬 045 I4’ (04 II .-4N 0 c

  3. Low-Dimensional Network Formation in Molten Sodium Carbonate

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wilding, Martin C.; Wilson, Mark; Alderman, Oliver L. G.

    2016-04-15

    Molten carbonates are highly inviscid liquids characterized by low melting points and high solubility of rare earth elements and volatile molecules. An understanding of the structure and related properties of these intriguing liquids has been limited to date. We report the results of a study of molten sodium carbonate (Na2CO3) which combines high energy X-ray diffraction, containerless techniques and computer simulation to provide insight into the liquid structure. Total structure factors (F-x(Q)) are collected on the laser-heated carbonate spheres suspended in flowing gases of varying composition in an aerodynamic levitation furnace. The respective partial structure factor contributions to Fx(Q) aremore » obtained by performing molecular dynamics simulations treating the carbonate anions as flexible entities. The carbonate liquid structure is found to be heavily temperature-dependent. At low temperatures a low-dimensional carbonate chain network forms, at T = 1100 K for example similar to 55% of the C atoms form part of a chain. The mean chain lengths decrease as temperature is increased and as the chains become shorter the rotation of the carbonate anions becomes more rapid enhancing the diffusion of Na+ ions.« less

  4. Monte-Carlo methods make Dempster-Shafer formalism feasible

    NASA Technical Reports Server (NTRS)

    Kreinovich, Vladik YA.; Bernat, Andrew; Borrett, Walter; Mariscal, Yvonne; Villa, Elsa

    1991-01-01

    One of the main obstacles to the applications of Dempster-Shafer formalism is its computational complexity. If we combine m different pieces of knowledge, then in general case we have to perform up to 2(sup m) computational steps, which for large m is infeasible. For several important cases algorithms with smaller running time were proposed. We prove, however, that if we want to compute the belief bel(Q) in any given query Q, then exponential time is inevitable. It is still inevitable, if we want to compute bel(Q) with given precision epsilon. This restriction corresponds to the natural idea that since initial masses are known only approximately, there is no sense in trying to compute bel(Q) precisely. A further idea is that there is always some doubt in the whole knowledge, so there is always a probability p(sub o) that the expert's knowledge is wrong. In view of that it is sufficient to have an algorithm that gives a correct answer a probability greater than 1-p(sub o). If we use the original Dempster's combination rule, this possibility diminishes the running time, but still leaves the problem infeasible in the general case. We show that for the alternative combination rules proposed by Smets and Yager feasible methods exist. We also show how these methods can be parallelized, and what parallelization model fits this problem best.

  5. The Effect of Herbaceous Legume of Feed in In-Vitro Digestibility

    NASA Astrophysics Data System (ADS)

    Ratnawaty, S.; Hartutik; Chuzaemi, S.

    2018-02-01

    This study was carried out to evaluate in-vitro digestibility of herbal legumesin feed. The materials used in this study were three types of herbal legumes namely Clitoria ternatea Q5455 (CT Q5455), Clitoria ternatea cv. Milgarra (CT cv Milgarra) and Stylosanthes seabrana (S. seabrana), The treatments were P0 = 100% Grass; P1 = 50% Grass+ 50% CT Q5455, P2 = 50% Grass + 50% CT cv. Milgarra, P3 = 50% Grass + 50% S. seabrana. The result showed that the treatments had a significant effect (P <0.05). The highest dry matter (DM) digestibilitywas in P1 (60.35%) and P3 (60.22%). The DM digestibility of the highest raw materials was in CT cv. Milgarra (73.49%) and the lowest one was in S. seabrana (63.90%). The treatments had a very significant effect (P <0.01) on the organic matter (OM) Digestibility. The highest OM digestibility wasin P1 (63.04%) and P3 (61.89%). The highest value of OM digestibility of raw materials was in CT cv. Milgarra (73.90%) and the lowest one was in S. seabrana (63.85%). The treatmentshad a significant effect (P <0.05) on the crude protein (CP) digestibility. The average CP digestibility of feed was at the same value in all treatments but in CT Q5455 (67.25%). The treatmentshad a significant effect (P <0.05) on the total digestible nutrients (TDN). The highest TDN was in P1 (66.19%) and the lowest one was in P0 (51.38%). Average TDN of the highest raw material was in CT cv. Milgarra (77.59%) and the lowest was in S. seabrana (67.04%).

  6. Relative bioavailability and antioxidant potential of two coenzyme q10 preparations.

    PubMed

    Kurowska, Elzbieta M; Dresser, George; Deutsch, Luisa; Bassoo, Errol; Freeman, David J

    2003-01-01

    Coenzyme Q10 (CoQ10) is synthesized by the human body and found in certain foods. Daily supplementation of CoQ10 could protect against heart disease but the bioavailability of CoQ10 supplements depends on the formulation taken. We compared the bioavailability and antioxidant properties of two commercial CoQ10 formulations, a commercial grade CoQ10 powder (commercial grade CoQ) and a new BT-CoQ10 BIO-TRANSFORMED (BT-CoQ10) obtained by fermentation of a soy-based, CoQ10-rich media with baker's yeast. Eleven healthy individuals participated in a randomized two-way crossover trial, with a 3-week washout period. Capsules containing 300 mg of either BT-CoQ10 or commercial grade CoQ10 were given daily for 1 week and multiple blood samples were taken for CoQ10, glutathione and glutathione peroxidase (GPx) determination. In 3 subjects, baseline plasma CoQ10 levels were lower prior to BT than prior to commercial grade CoQ treatment. In the remaining participants, ingestion of BT vs. commercial grade CoQ significantly increased maximum plasma CoQ10 concentration (+126%, p = 0.04) and tended to increase CoQ10 area under the curve from 0 to 24 h (+160%, p = 0.07). One week of treatment with each formulation increased plasma CoQ10 but did not alter plasma glutathione or GPx activity. The enhanced bioavailability of the BT product might be due to its predominantly reduced, hydrophilic membrane-complex form. Copyright 2003 S. Karger AG, Basel

  7. 17 CFR 171.4 - Computation of time.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Computation of time. 171.4 Section 171.4 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION RULES RELATING TO... computing any period of time prescribed by these rules or allowed by the Commission, the day of the act...

  8. 17 CFR 12.5 - Computation of time.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Computation of time. 12.5 Section 12.5 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION RULES RELATING TO... general. In computing any period of time prescribed by these rules or allowed by the Commission, the...

  9. (q,{mu}) and (p,q,{zeta})-exponential functions: Rogers-Szego'' polynomials and Fourier-Gauss transform

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hounkonnou, Mahouton Norbert; Nkouankam, Elvis Benzo Ngompe

    2010-10-15

    From the realization of q-oscillator algebra in terms of generalized derivative, we compute the matrix elements from deformed exponential functions and deduce generating functions associated with Rogers-Szego polynomials as well as their relevant properties. We also compute the matrix elements associated with the (p,q)-oscillator algebra (a generalization of the q-one) and perform the Fourier-Gauss transform of a generalization of the deformed exponential functions.

  10. A Communication-Optimal Framework for Contracting Distributed Tensors

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rajbhandari, Samyam; NIkam, Akshay; Lai, Pai-Wei

    Tensor contractions are extremely compute intensive generalized matrix multiplication operations encountered in many computational science fields, such as quantum chemistry and nuclear physics. Unlike distributed matrix multiplication, which has been extensively studied, limited work has been done in understanding distributed tensor contractions. In this paper, we characterize distributed tensor contraction algorithms on torus networks. We develop a framework with three fundamental communication operators to generate communication-efficient contraction algorithms for arbitrary tensor contractions. We show that for a given amount of memory per processor, our framework is communication optimal for all tensor contractions. We demonstrate performance and scalability of our frameworkmore » on up to 262,144 cores of BG/Q supercomputer using five tensor contraction examples.« less

  11. Dollar Summary of Prime Contract Awards by Contractor, State or Country, and Place, FY 88. Part 6 (Spick & Spain Maintenance, Inc.-Zymed, Inc.).

    DTIC Science & Technology

    1988-01-01

    A. 3000O.LiO. 0 C 0 ) 0- m-) CDZ( 1 01 el i 0 I Q ,InL 1 01 I I I I 0I0 I En I I V I 1-- 0fI J ))(( 1 U-I n M-C1 Ir I CI) ZI00 MU m’ uC’ (0(0) m~e 0...w w w w wC 0 de <<-l 0 10 0) -4z -4 1 C>IWWW 4L4WW- 0 I--1 U) 101 CCC 0 0L W U’ 2i 000 00 W00 0i 0i- i WI- 4) ’-4- 00-I C1 0 a 4 4W w 4 . C 4 " 4.U...000 00 0 0 04 0 000 00V I Z4 I -- 4> .. 4 "U 4- .4.I- " P.4-4 )- "- 0) 4- >>- 0. 04-2 4. Q. M 0 m J CL)00 0))0 C0 a_ a.C -C( aULa L L M a a La D Z3

  12. The IEEE International Conference on Data Mining (10th) Held in Sydney, Australia on 14-17 December 2010

    DTIC Science & Technology

    2010-12-17

    Approach to Modeling Personalized Contexts of Mobile Users Tengfei Bao, Happia Cao, Enhong Chen, Jilei Tian, and Hui Xiong q Fast and Flexible...Kutsuna q Detecting Blackhole and Volcano Patterns in Directed Networks Zhongmou Li, Hui Xiong , Yanchi Liu, and Aoying Zhou q Exploiting Local Data...Density-Based Network Clustering via Structure-Connected Tree Division or Agglomeration Heli Sun, Jianbin Huang, Jiawei Han, Hongbo Deng, Peixiang Zhao

  13. Understanding the Relationship Between Structure and Thermophysical Properties of CaO-SiO2-MgO-Al2O3 Molten Slags

    NASA Astrophysics Data System (ADS)

    Sun, Yongqi; Wang, Hao; Zhang, Zuotai

    2018-04-01

    In the present work, the relationship between the microscopic structure and macroscopic thermophysical properties in a basic CaO-SiO2-MgO-Al2O3 quaternary system was identified using Fourier transformation infrared, Raman and 27Al magic angular spinning nuclear magnetic resonance (MAS-NMR) techniques. The Raman spectra quantitatively proved that with increasing Al2O3 content, the concentrations of the symmetric units of Q 0(Si) and Q 2(Si) decreased, while those of the asymmetric units of Q 1(Si) and Q 3(Si) increased; consequently, the degree of polymerization of the networks increased, which resulted in an increase in slag viscosity. The 27Al MAS-NMR spectra demonstrated that three structural units of Al atoms, namely, AlO4, AlO5, and AlO6, mainly existed in the networks. With increasing Al2O3 content, the concentration of AlO4 slightly decreased, while those of AlO5 and AlO6 increased; overall, Al2O3 acted as a network former in the present system. The increasing Al2O3 content led to additional AlO6 and Si-NBO-Ca-NBO-Al frameworks, which replaced Si-NBO-Ca-NBO-Si in the networks (NBO: non-bridging oxygen) and induced a change in the primarily precipitated crystalline phase from Ca2MgSi2O7 and Ca2Al2SiO7 to MgAlO4.

  14. A new color vision test to differentiate congenital and acquired color vision defects.

    PubMed

    Shin, Young Joo; Park, Kyu Hyung; Hwang, Jeong-Min; Wee, Won Ryang; Lee, Jin Hak

    2007-07-01

    To investigate the efficacy of a novel computer-controlled color test for the differentiation of congenital and acquired color vision deficiency. Observational cross-sectional study. Thirty-one patients with congenital color vision deficiency and 134 patients with acquired color vision deficiency with a Snellen visual acuity better than 20/30 underwent an ophthalmologic examination including the Ishihara color test, Hardy-Rand-Rittler test, Nagel anomaloscopy, and the Seohan computerized hue test between June, 2003, and January, 2004. To investigate the type of color vision defect, a graph of the Seohan computerized hue test was divided into 4 quadrants and error scores in each quadrant were summated. The ratio between the sums of error scores of quadrants I and III (Q1+Q3) and those of quadrants II and IV (Q2+Q4) was calculated. Error scores and ratio in quadrant analysis of the Seohan computerized hue test. The Seohan computerized hue test showed that the sum of Q2+Q4 was significantly higher than the sum of Q1+Q3 in congenital color vision deficiency (P<0.01, paired t test) and that the sum of Q2+Q4 was significantly lower than the sum of Q1+Q3 in acquired color vision deficiency (P<0.01, paired t test). In terms of discriminating congenital and acquired color vision deficiency, the ratio in quadrant analysis had 93.3% sensitivity and 98.5% specificity with a reference value of 1.5 by the Seohan computerized hue test (95% confidence interval). The quadrant analysis and ratio of (Q2+Q4)/(Q1+Q3) using the Seohan computerized hue test effectively differentiated congenital and acquired color vision deficiency.

  15. A prospective study of soluble receptor for advanced glycation end products and adipokines in association with pancreatic cancer in postmenopausal women.

    PubMed

    White, Donna L; Hoogeveen, Ron C; Chen, Liang; Richardson, Peter; Ravishankar, Milan; Shah, Preksha; Tinker, Lesley; Rohan, Thomas; Whitsel, Eric A; El-Serag, Hashem B; Jiao, Li

    2018-05-01

    Advanced glycation end products (AGEs) dysregulate adipokines and induce inflammation by binding to their adipocyte receptor (RAGE). Soluble RAGE (sRAGE) prevents AGEs/RAGE signaling. We performed a nested case-control study of the association between sRAGE, adipokines, and incident pancreatic cancer risk in the prospective Women's Health Initiative Study. We individually matched controls (n = 802) to cases (n = 472) on age, race, and blood draw date. We evaluated serum concentrations of sRAGE, adiponectin, leptin, monocyte chemotactic protein 1 (MCP1), and plasminogen activator inhibitor-1 (PAI1) using immunoassay. We used conditional logistic regression model to estimate adjusted odds ratios (aORs) and 95% confidence intervals (CIs) for pancreatic cancer over biomarker quartiles (Q1-Q4). We used principal component analysis to create two composite biomarkers and performed a confirmatory factor analysis to examine the association between composite biomarker scores (CBS) and pancreatic cancer risk. Baseline serum sRAGE concentrations were inversely associated with pancreatic cancer risk (aOR Q4 vs. Q1  = 0.70, 95% CI: 0.50-0.99). High MCP1 (aOR Q4 vs. Q1  = 2.55, 95% CI: 1.41-4.61) and the higher CBS including MCP1, PAI1, and leptin (aOR Q4 vs. Q1  = 1.82, 95% CI = 1.04-3.18) were also associated with increased pancreatic cancer risk among women with BMI <25 kg/m 2 (P values for interaction <0.05). We found an inverse association between prediagnostic sRAGE concentrations and risk of incident pancreatic cancer in postmenopausal women. A proinflammatory CBS was associated with increased risk only in women with normal BMI. MCP1 was not modulated by sRAGE. © 2018 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

  16. On the mesoscale monitoring capability of Argo floats in the Mediterranean Sea

    NASA Astrophysics Data System (ADS)

    Sánchez-Román, Antonio; Ruiz, Simón; Pascual, Ananda; Mourre, Baptiste; Guinehut, Stéphanie

    2017-03-01

    In this work a simplified observing system simulation experiment (OSSE) approach is used to investigate which Argo design sampling in the Mediterranean Sea would be necessary to properly capture the mesoscale dynamics in this basin. The monitoring of the mesoscale features is not an initial objective of the Argo network. However, it is an interesting question from the perspective of future network extensions in order to improve the ocean state estimates. The true field used to conduct the OSSEs is provided by a specific altimetry-gridded merged product for the Mediterranean Sea. Synthetic observations were obtained by sub-sampling this Nature Run according to different configurations of the ARGO network. The observation errors required to perform the OSSEs were obtained through the comparison of sea level anomalies (SLAs) from altimetry and dynamic height anomalies (DHAs) computed from the real in situ Argo network. This analysis also contributes to validate satellite SLAs with an increased confidence. The simulation experiments show that a configuration similar to the current Argo array in the Mediterranean (with a spatial resolution of 2° × 2°) is only able to recover the large-scale signals of the basin. Increasing the spatial resolution to nearly 75 km × 75 km, allows the capture of most of the mesoscale signal in the basin and to retrieve the SLA field with a RMSE of 3 cm for spatial scales larger than 150 km, similar to those presently captured by the altimetry. This would represent a theoretical reduction of 40 % of the actual RMSE. Such a high-resolution Argo array composed of around 450 floats, cycling every 10 days, is expected to increase the actual network cost by approximately a factor of 6.

  17. Interval-type and affine arithmetic-type techniques for handling uncertainty in expert systems

    NASA Astrophysics Data System (ADS)

    Ceberio, Martine; Kreinovich, Vladik; Chopra, Sanjeev; Longpre, Luc; Nguyen, Hung T.; Ludascher, Bertram; Baral, Chitta

    2007-02-01

    Expert knowledge consists of statements Sj (facts and rules). The facts and rules are often only true with some probability. For example, if we are interested in oil, we should look at seismic data. If in 90% of the cases, the seismic data were indeed helpful in locating oil, then we can say that if we are interested in oil, then with probability 90% it is helpful to look at the seismic data. In more formal terms, we can say that the implication "if oil then seismic" holds with probability 90%. Another example: a bank A trusts a client B, so if we trust the bank A, we should trust B too; if statistically this trust was justified in 99% of the cases, we can conclude that the corresponding implication holds with probability 99%. If a query Q is deducible from facts and rules, what is the resulting probability p(Q) in Q? We can describe the truth of Q as a propositional formula F in terms of Sj, i.e., as a combination of statements Sj linked by operators like &, [logical or], and [not sign]; computing p(Q) exactly is NP-hard, so heuristics are needed. Traditionally, expert systems use technique similar to straightforward interval computations: we parse F and replace each computation step with corresponding probability operation. Problem: at each step, we ignore the dependence between the intermediate results Fj; hence intervals are too wide. Example: the estimate for P(A[logical or][not sign]A) is not 1. Solution: similar to affine arithmetic, besides P(Fj), we also compute P(Fj&Fi) (or P(Fj1&...&Fjd)), and on each step, use all combinations of l such probabilities to get new estimates. Results: e.g., P(A[logical or][not sign]A) is estimated as 1.

  18. U.S. EPA, Pesticide Product Label, , 04/02/1982

    EPA Pesticide Factsheets

    2011-04-13

    ... (~ .. t. , ... Do ret ~p'~ """ w ,pt"¥'Ii cl ,"1, pro.;!~C' i'" Cf'l'\\dv'h "'O'Ot ""ev,'r::l' It"'c'!o" al'ld , .... ... foy":->Q,.t .. t"r ., ,t." ~ ",otc" 0" p'I,I~9 •• ,te"'" In '''f' ...

  19. Yogurt consumption and abdominal obesity reversion in the PREDIMED study.

    PubMed

    Santiago, S; Sayón-Orea, C; Babio, N; Ruiz-Canela, M; Martí, A; Corella, D; Estruch, R; Fitó, M; Aros, F; Ros, E; Gómez-García, E; Fiol, M; Lapetra, J; Serra-Majem, Ll; Becerra-Tomás, N; Salas-Salvadó, J; Pinto, X; Schröder, H; Martínez, J A

    2016-06-01

    Evidence on the association yogurt consumption and obesity is not conclusive. The aim of this study was to prospectively evaluate the association between yogurt consumption, reversion of abdominal obesity status and waist circumference change in elderly. 4545 individuals at high cardiovascular risk were prospectively followed. Total, whole-fat and low-fat yogurt consumption were assessed using food frequency questionnaires. Generalized estimating equations were used to analyze the association between yogurt consumption and waist circumference change (measured at baseline and yearly during the follow-up). Logistic regression models were used to evaluate the odds ratios (ORs) and 95% CIs of the reversion rate of abdominal obesity for each quintile of yogurt consumption compared with the lowest quintile. After multivariable adjustment, the average yearly waist circumference change in the quintiles of whole-fat yogurt consumption was: Q1: 0.00, Q2: 0.00 (-0.23 to 0.23), Q3: -0.15 (-0.42 to 0.13), Q4: 0.10 (-0.21 to 0.42), and Q5: -0.23 (-0.46 to -0.00) cm; p for trend = 0.05. The ORs for the reversion of abdominal obesity for whole-fat yogurt consumption were Q1: 1.00, Q2: 1.40 (1.04-1.90), Q3: 1.33 (0.94-1.89), Q4: 1.21 (0.83-1.77), and Q5: 1.43 (1.06-1.93); p for trend = 0.26. Total yogurt consumption was not significantly associated with reversion of abdominal obesity status and a lower waist circumference. However, consumption of whole-fat yogurt was associated with changes in waist circumference and higher probability for reversion of abdominal obesity. Therefore, it seems that whole-fat yogurt has more beneficial effects in management of abdominal obesity in elderly population at high cardiovascular risk. Copyright © 2015 The Italian Society of Diabetology, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition, and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.

  20. Gene amplification of the transcription factor DP1 and CTNND1 in human lung cancer.

    PubMed

    Castillo, Sandra D; Angulo, Barbara; Suarez-Gauthier, Ana; Melchor, Lorenzo; Medina, Pedro P; Sanchez-Verde, Lydia; Torres-Lanzas, Juan; Pita, Guillermo; Benitez, Javier; Sanchez-Cespedes, Montse

    2010-09-01

    The search for novel oncogenes is important because they could be the target of future specific anticancer therapies. In the present paper we report the identification of novel amplified genes in lung cancer by means of global gene expression analysis. To screen for amplicons, we aligned the gene expression data according to the position of transcripts in the human genome and searched for clusters of over-expressed genes. We found several clusters with gene over-expression, suggesting an underlying genomic amplification. FISH and microarray analysis for DNA copy number in two clusters, at chromosomes 11q12 and 13q34, confirmed the presence of amplifications spanning about 0.4 and 1 Mb for 11q12 and 13q34, respectively. Amplification at these regions each occurred at a frequency of 3%. Moreover, quantitative RT-PCR of each individual transcript within the amplicons allowed us to verify the increased in gene expression of several genes. The p120ctn and DP1 proteins, encoded by two candidate oncogenes, CTNND1 and TFDP1, at 11q12 and 13q amplicons, respectively, showed very strong immunostaining in lung tumours with gene amplification. We then focused on the 13q34 amplicon and in the TFDP1 candidate oncogene. To further determine the oncogenic properties of DP1, we searched for lung cancer cell lines carrying TFDP1 amplification. Depletion of TFDP1 expression by small interference RNA in a lung cancer cell line (HCC33) with TFDP1 amplification and protein over-expression reduced cell viability by 50%. In conclusion, we report the identification of two novel amplicons, at 13q34 and 11q12, each occurring at a frequency of 3% of non-small cell lung cancers. TFDP1, which encodes the E2F-associated transcription factor DP1 is a candidate oncogene at 13q34. The data discussed in this publication have been deposited in NCBIs Gene Expression Omnibus (GEO; http://www.ncbi.nlm.nih.gov/geo/) and are accessible through GEO Series Accession No. GSE21168.

  1. Mechanism and prognostic role of qR in V1 in patients with pulmonary arterial hypertension.

    PubMed

    Waligóra, Marcin; Kopeć, Grzegorz; Jonas, Kamil; Tyrka, Anna; Sarnecka, Agnieszka; Miszalski-Jamka, Tomasz; Urbańczyk-Zawadzka, Małgorzata; Podolec, Piotr

    The presence of qR pattern in lead V 1 of the 12-lead surface ECG has been proposed as a risk marker of death in patients with pulmonary arterial hypertension (PAH). We aimed to validate these findings in the modern era of PAH treatment and additionally to assess the relation of qR in V 1 to PAH severity. We also investigated the possible mechanisms underlying this ECG sign. Consecutive patients with PAH excluding patients with congenital heart defect were recruited between February 2008 and January 2016. A 12-lead standard ECG was acquired and analyzed for the presence of qR in V 1 and other potential prognostic patterns. Cardiac magnetic resonance and echocardiography were used for structural (masses and volumes) and functional (ejection fraction, eccentricity index) characterization of left (LV) and right (RV) ventricles. Standard markers of PAH severity were also assessed. We enrolled 66 patients (19 males), aged 50.0±15.7years with idiopathic PAH (n=52) and PAH associated with connective tissue disease (n=14). qR in V 1 was present in 26(39.4%) patients and was associated with worse functional capacity, hemodynamics and RV function. The main structural determinants of qR in V 1 were RV to LV volume ratio (OR: 3.99; 95% CI: 1.47-10.8, p=0.007) and diastolic eccentricity index (OR: 15.0; 95% CI: 1.29-175.5, p=0.03). During observation time of 30.5±19.4months, 20 (30.3%) patient died, 13 (50%) patients with qR and 7 (17.5%) patients without qR pattern. Electrocardiographic determinants of survival were qR (HR: 3.06, 95% CI: 1.21-7.4; p=0.02) and QRS duration (HR: 1.02, 95% CI: 1.01-1.04; p=0.01). Presence of qR in V 1 reflects RV dilation and diastolic interventricular septum flattening. It is a sign of advanced PAH and predicts the risk of death in this population. Copyright © 2017 Elsevier Inc. All rights reserved.

  2. Nonlinear Cascades of Surface Oceanic Geostrophic Kinetic Energy in the Frequency Domain

    DTIC Science & Technology

    2012-09-01

    kinetic energy in wavenumber k space for surface ocean geostrophic flows have been computed from sat - ellite altimetry data of sea surface height (Scott...5 0.65kN, where kN corresponds to the Nyquist scale. The filter is applied to bq 1 and bq 2 , the Fourier transforms of q1 and q2, at every time step

  3. Astropulse: A Search for Microsecond Transient Radio Signals Using Distributed Computing. I. Methodology

    NASA Astrophysics Data System (ADS)

    Von Korff, J.; Demorest, P.; Heien, E.; Korpela, E.; Werthimer, D.; Cobb, J.; Lebofsky, M.; Anderson, D.; Bankay, B.; Siemion, A.

    2013-04-01

    We are performing a transient, microsecond timescale radio sky survey, called "Astropulse," using the Arecibo telescope. Astropulse searches for brief (0.4 μs to 204.8 μs ), wideband (relative to its 2.5 MHz bandwidth) radio pulses centered at 1420 MHz. Astropulse is a commensal (piggyback) survey, and scans the sky between declinations of -1.°33 and 38.°03. We obtained 1540 hr of data in each of seven beams of the ALFA receiver, with two polarizations per beam. The data are one-bit complex sampled at the Nyquist limit of 0.4 μs per sample. Examination of timescales on the order of microseconds is possible because we used coherent dedispersion, a technique that has frequently been used for targeted observations, but has never been associated with a radio sky survey. The more usual technique, incoherent dedispersion, cannot resolve signals below a minimum timescale which depends on the signal's dispersion measure (DM) and frequency. However, coherent dedispersion requires more intensive computation than incoherent dedispersion. The required processing power was provided by BOINC, the Berkeley Open Infrastructure for Network Computing. BOINC is a distributed computing system, allowing us to utilize hundreds of thousands of volunteers' computers to perform the necessary calculations for coherent dedispersion. Astrophysical events that might produce brief radio pulses include giant pulses from pulsars, rotating radio transients, exploding primordial black holes, or new sources yet to be imagined. Radio frequency interference and noise contaminate the data; these are mitigated by a number of techniques including multi-polarization correlation, DM repetition detection, and frequency profiling.

  4. Does the type of sport practised influence foot posture and knee angle? Differences between footballers and swimmers.

    PubMed

    Lopezosa-Reca, Eva; Gijon-Nogueron, Gabriel; Garcia-Paya, Irene; Ortega-Avila, Ana Belen

    2018-03-04

    This aim of this study is to observe the differences in foot posture and the angle of the knee according to different physical activities. Seventy-eight football players and 72 swimmers were recruited, and in each case a foot posture analysis, based on the foot posture index (FPI), was conducted and the Q angle of the knee was determined. The following mean values were obtained for the lower extremities: in the swimmers, FPI 6.45 ± 2.04 and Q angle 15.38º ± 3.79º. In the footballers, FPI 2.23 ± 1.72 and Q angle 13.16º ± 1.36º. There were statistically significant differences (p < 0.001) between the two groups. The swimmers presented a foot posture with a tendency towards pronation, and a Q angle with a tendency towards valgus, while the results for the footballers were within the normal range.

  5. Dynamical susceptibility near a long-wavelength critical point with a nonconserved order parameter

    NASA Astrophysics Data System (ADS)

    Klein, Avraham; Lederer, Samuel; Chowdhury, Debanjan; Berg, Erez; Chubukov, Andrey

    2018-04-01

    We study the dynamic response of a two-dimensional system of itinerant fermions in the vicinity of a uniform (Q =0 ) Ising nematic quantum critical point of d - wave symmetry. The nematic order parameter is not a conserved quantity, and this permits a nonzero value of the fermionic polarization in the d - wave channel even for vanishing momentum and finite frequency: Π (q =0 ,Ωm)≠0 . For weak coupling between the fermions and the nematic order parameter (i.e., the coupling is small compared to the Fermi energy), we perturbatively compute Π (q =0 ,Ωm)≠0 over a parametrically broad range of frequencies where the fermionic self-energy Σ (ω ) is irrelevant, and use Eliashberg theory to compute Π (q =0 ,Ωm) in the non-Fermi-liquid regime at smaller frequencies, where Σ (ω )>ω . We find that Π (q =0 ,Ω ) is a constant, plus a frequency-dependent correction that goes as |Ω | at high frequencies, crossing over to |Ω| 1 /3 at lower frequencies. The |Ω| 1 /3 scaling holds also in a non-Fermi-liquid regime. The nonvanishing of Π (q =0 ,Ω ) gives rise to additional structure in the imaginary part of the nematic susceptibility χ″(q ,Ω ) at Ω >vFq , in marked contrast to the behavior of the susceptibility for a conserved order parameter. This additional structure may be detected in Raman scattering experiments in the d - wave geometry.

  6. Gene expression ratio stability evaluation in prepubertal bovine mammary tissue from calves fed different milk replacers reveals novel internal controls for quantitative polymerase chain reaction.

    PubMed

    Piantoni, Paola; Bionaz, Massimo; Graugnard, Daniel E; Daniels, Kristy M; Akers, R Michael; Loor, Juan J

    2008-06-01

    Prepubertal mammary development can be affected by nutrition partly through alterations in gene network expression. Quantitative PCR (qPCR) remains the most accurate method to measure mRNA expression but is subject to analytical errors that introduce variation. Thus, qPCR data normalization through the use of internal control genes (ICG) is required. The objective of this study was to mine microarray data (> 10,000 genes) from prepubertal mammary parenchyma and stroma to identify the most suitable ICG for normalization of qPCR. Tissue for RNA extraction was obtained from calves ( approximately 63 d old; n = 5/diet) fed a control (200 g/kg crude protein, 210 g/kg crude fat, fed at 441 g/d dry matter) or a high-protein milk replacer (280 g/kg crude protein, 200 g/kg crude fat, fed at 951 g/d dry matter). ICG were selected based on both absence of expression variation across treatment and of coregulation (gene network analysis). Genes evaluated were ubiquitously expressed transcript, protein phosphatase 1 regulatory (inhibitor) subunit 11 (PPP1R11), matrix metallopeptidase 14 (MMP14), ClpB caseinolytic peptidase B, SAPS domain family member 1 (SAPS1), mitochondrial GTPase 1 (MTG1), mitochondrial ribosomal protein L39, ribosomal protein S15a (RPS15A), and actin beta (ACTB). Network analysis demonstrated that MMP14 and ACTB are coregulated by v-myc myelocytomatosis viral oncogene, tumor protein p53, and potentially insulin-like growth factor 1. Pairwise comparison of expression ratios showed that ACTB, MMP14, and SAPS1 had the lowest stability and were unsuitable as ICG. PPP1R11, RPS15A, and MTG1 were the most stable among ICG tested. We conclude that the geometric mean of PPP1R11, RPS15A, and MTG1 is ideal for normalization of qPCR data in prepubertal bovine mammary tissue. This study provides a list of candidate ICG that could be used by researchers working in bovine mammary development and allied fields.

  7. 26 CFR 1.383-2 - Limitations on certain capital losses and excess credits in computing alternative minimum tax...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 26 Internal Revenue 4 2010-04-01 2010-04-01 false Limitations on certain capital losses and excess credits in computing alternative minimum tax. [Reserved] 1.383-2 Section 1.383-2 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Insolvency...

  8. Network-Physics(NP) Bec DIGITAL(#)-VULNERABILITY Versus Fault-Tolerant Analog

    NASA Astrophysics Data System (ADS)

    Alexander, G. K.; Hathaway, M.; Schmidt, H. E.; Siegel, E.

    2011-03-01

    Siegel[AMS Joint Mtg.(2002)-Abs.973-60-124] digits logarithmic-(Newcomb(1881)-Weyl(1914; 1916)-Benford(1938)-"NeWBe"/"OLDbe")-law algebraic-inversion to ONLY BEQS BEC:Quanta/Bosons= digits: Synthesis reveals EMP-like SEVERE VULNERABILITY of ONLY DIGITAL-networks(VS. FAULT-TOLERANT ANALOG INvulnerability) via Barabasi "Network-Physics" relative-``statics''(VS.dynamics-[Willinger-Alderson-Doyle(Not.AMS(5/09)]-]critique); (so called)"Quantum-computing is simple-arithmetic(sans division/ factorization); algorithmic-complexities: INtractibility/ UNdecidability/ INefficiency/NONcomputability / HARDNESS(so MIScalled) "noise"-induced-phase-transitions(NITS) ACCELERATION: Cook-Levin theorem Reducibility is Renormalization-(Semi)-Group fixed-points; number-Randomness DEFINITION via WHAT? Query(VS. Goldreich[Not.AMS(02)] How? mea culpa)can ONLY be MBCS "hot-plasma" versus digit-clumping NON-random BEC; Modular-arithmetic Congruences= Signal X Noise PRODUCTS = clock-model; NON-Shor[Physica A,341,586(04)] BEC logarithmic-law inversion factorization:Watkins number-thy. U stat.-phys.); P=/=NP TRIVIAL Proof: Euclid!!! [(So Miscalled) computational-complexity J-O obviation via geometry.

  9. Red and processed meat intake and cancer risk: Results from the prospective NutriNet-Santé cohort study.

    PubMed

    Diallo, Abou; Deschasaux, Mélanie; Latino-Martel, Paule; Hercberg, Serge; Galan, Pilar; Fassier, Philippine; Allès, Benjamin; Guéraud, Françoise; Pierre, Fabrice H; Touvier, Mathilde

    2018-01-15

    The International Agency for Research on Cancer (WHO-IARC) classified red meat and processed meat as probably carcinogenic and carcinogenic for humans, respectively. These conclusions were mainly based on studies concerning colorectal cancer, but scientific evidence is still limited for other cancer locations. In this study, we investigated the prospective associations between red and processed meat intakes and overall, breast, and prostate cancer risk. This prospective study included 61,476 men and women of the French NutriNet-Santé cohort (2009-2015) aged ≥35 y and who completed at least three 24 hrs dietary records during the first year of follow-up. The risk of developing cancer was compared across sex-specific quintiles of red and processed meat intakes by multivariable Cox models. 1,609 first primary incident cancer cases were diagnosed during follow-up, among which 544 breast cancers and 222 prostate cancers. Red meat intake was associated with increased risk of overall cancers [HR Q5 vs. Q1 =1.31 (1.10-1.55), p trend  = 0.01) and breast cancer (HR Q5 vs. Q1  = 1.83 (1.33-2.51), p trend  = 0.002]. The latter association was observed in both premenopausal [HR Q5 vs. Q1 =2.04 (1.03-4.06)] and postmenopausal women [HR Q5 vs. Q1 =1.79 (1.26-2.55)]. No association was observed between red meat intake and prostate cancer risk. Processed meat intake was relatively low in this study (cut-offs for the 5th quintile = 46 g/d in men and 29 g/d in women) and was not associated with overall, breast or prostate cancer risk. This large cohort study suggested that red meat may be involved carcinogenesis at several cancer locations (other than colon-rectum), in particular breast cancer. These results are consistent with mechanistic evidence from experimental studies. © 2017 UICC.

  10. Loss of heterozygosity patterns provide fingerprints for genetic heterogeneity in multistep cancer progression of tobacco smoke-induced non-small cell lung cancer.

    PubMed

    Pan, Hongjie; Califano, Joseph; Ponte, Jose F; Russo, Andrea L; Cheng, Kuang-hung; Thiagalingam, Arunthathi; Nemani, Pratima; Sidransky, David; Thiagalingam, Sam

    2005-03-01

    Dilution end point loss of heterozygosity (LOH) analysis, a novel approach for the analysis of LOH, was used to evaluate allelic losses with the use of 21 highly polymorphic microsatellite markers at nine chromosomal sites most frequently affected in smoking-related non-small cell lung cancers. Allelotyping was done for bronchial epithelial cells and matching blood samples from 23 former and current smokers and six nonsmokers as well as in 33 adenocarcinomas and 25 squamous cell carcinomas (SCC) and corresponding matching blood from smokers. Major conclusions from these studies are as follows: (a) LOH at chromosomal sites 8p, 9p, 11q, and 13q (P >0.05, Fisher's exact test) are targeted at the early stages, whereas LOH at 1p, 5q, 17p, and 18q (P <0.05, Fisher's exact test) occur at the later stages of non-small cell lung cancer progression; (b) LOH at 1p, 3p, 5q, 8p, 9p, 11q, 13q, 17p, and 18q occurs in over 45% of the tobacco smokers with SCC and adenocarcinoma; (c) compared with bronchial epithelial cells from smokers, there is a significantly higher degree of LOH at 1p, 5q, and 18q in adenocarcinoma and at 1p, 3p, and 17p in SCC (P <0.05, Fisher's exact test). We propose that lung cancer progression induced by tobacco smoke occurs in a series of target gene inactivations/activations in defined modules of a global network. The gatekeeper module consists of multiple alternate target genes, which is inclusive of but not limited to genes localized to chromosomal loci 8p, 9p, 11q, and 13q.

  11. Containment of Clostridium difficile infection without reduction in antimicrobial use in Hong Kong.

    PubMed

    Cheng, V C C; Chau, P H; So, S Y C; Chen, J H K; Poon, R W S; Wong, S C Y; Hung, I F N; Lee, W M; Tai, J W M; Ho, P L; Yam, W C; Yuen, K Y

    2015-07-01

    Clostridium difficile ribotype 002 with hypersporulating capacity has been increasingly identified in Hong Kong. Proactive infection control measures are important to prevent the establishment of endemicity of C. difficile ribotype 002. A total of 329 patients with healthcare-associated C. difficile infection (CDI) were recruited in our healthcare network between 1 January 2008 and 30 June 2012 in this study. The incidence rates of healthcare-associated CDI per 10,000 admissions and 10,000 patient-days increased significantly by 15.3 and 17.0%, respectively, per quarter (p < 0.001) from 2008 1Q to 2010 1Q by segmented Poisson regression. With the full implementation of enhanced infection control interventions, there was an immediate significant reduction in both healthcare-associated CDI rates per 10,000 admissions and per 10,000 patient-days by 47% (p < 0.001) in 2010 2Q, followed by a further decline of CDI per 10,000 admissions and CDI per 10,000 patient-days by -19.4 and -19.8% from 2010 2Q to 2012 2Q, respectively (p < 0.001), despite a replacement of hand washing with soap and water by alcohol-based hand rub in the healthcare network. The proportion of C. difficile ribotype 002 was not statistically different (34/177, 19.2% vs. 25/152, 16.4%, p = 0.515), and the consumption of broad-spectrum antibiotics presented as divided daily dose per 1,000 acute bed-day occupancy per quarter remained unchanged (140.9 vs. 152.3) before and after infection control interventions. Our results suggested that the reduction of healthcare-associated CDI was attributable to infection control interventions instead of replacement of ribotypes or reduction in antimicrobial selective pressure.

  12. Instrumentation for Detecting Hazardous Materials.

    DTIC Science & Technology

    1980-06-01

    CATALOG NUMBER 1940-4)_ _ _ _ _ _ 4. TITLE (,.d Subtitle) _ JVE OF r , AL*3O.[OYE_ D .- / Final ; , .. P - 4^NSTRUtENTAT ION FOR DETECTING HAZARDOUS...CL a D- 4- a ... E - 0US m -i M r i US U Ci 0 Ui . Ci C) Ci. 4.. 9* Ci0 44. 4-S i C U i 5U - . ’- -) 0 C- c -CiOZ E 0 04 CiC C’ - E-.0 m N 4- 10 m E4...1 z 0 - C)4 -4 54-1 C)) 04Q). 0U $4i 4I - 40. U a) 0)U r -H 0) -a 0r- u 1-- 1% 4J ( C.) 4 0 0 4~J >1) C) r ’ (0 4 T - -4 U) C C) 0 *- C)0 - 4 f 04 C) C

  13. Promoting Vicarious Learning of Physics Using Deep Questions with Explanations

    ERIC Educational Resources Information Center

    Craig, Scotty D.; Gholson, Barry; Brittingham, Joshua K.; Williams, Joah L.; Shubeck, Keith T.

    2012-01-01

    Two experiments explored the role of vicarious "self" explanations in facilitating student learning gains during computer-presented instruction. In Exp. 1, college students with low or high knowledge on Newton's laws were tested in four conditions: (a) monologue (M), (b) questions (Q), (c) explanation (E), and (d) question + explanation (Q + E).…

  14. Genome-wide linkage and positional candidate gene study of blood pressure response to dietary potassium intervention: the genetic epidemiology network of salt sensitivity study.

    PubMed

    Kelly, Tanika N; Hixson, James E; Rao, Dabeeru C; Mei, Hao; Rice, Treva K; Jaquish, Cashell E; Shimmin, Lawrence C; Schwander, Karen; Chen, Chung-Shuian; Liu, Depei; Chen, Jichun; Bormans, Concetta; Shukla, Pramila; Farhana, Naveed; Stuart, Colin; Whelton, Paul K; He, Jiang; Gu, Dongfeng

    2010-12-01

    Genetic determinants of blood pressure (BP) response to potassium, or potassium sensitivity, are largely unknown. We conducted a genome-wide linkage scan and positional candidate gene analysis to identify genetic determinants of potassium sensitivity. A total of 1906 Han Chinese participants took part in a 7-day high-sodium diet followed by a 7-day high-sodium plus potassium dietary intervention. BP measurements were obtained at baseline and after each intervention using a random-zero sphygmomanometer. Significant linkage signals (logarithm of odds [LOD] score, >3) for BP responses to potassium were detected at chromosomal regions 3q24-q26.1, 3q28, and 11q22.3-q24.3. Maximum multipoint LOD scores of 3.09 at 3q25.2 and 3.41 at 11q23.3 were observed for absolute diastolic BP (DBP) and mean arterial pressure (MAP) responses, respectively. Linkage peaks of 3.56 at 3q25.1 and 3.01 at 11q23.3 for percent DBP response and 3.22 at 3q25.2, 3.01 at 3q28, and 4.48 at 11q23.3 for percent MAP response also were identified. Angiotensin II receptor, type 1 (AGTR1), single-nucleotide polymorphism rs16860760 in the 3q24-q26.1 region was significantly associated with absolute and percent systolic BP responses to potassium (P=0.0008 and P=0.0006, respectively). Absolute (95% CI) systolic BP responses for genotypes C/C, C/T, and T/T were -3.71 (-4.02 to -3.40), -2.62 (-3.38 to -1.85), and 1.03 (-3.73 to 5.79) mm Hg, respectively, and percent responses (95% CI) were -3.07 (-3.33 to -2.80), -2.07 (-2.74 to -1.41), and 0.90 (-3.20 to 4.99), respectively. Similar trends were observed for DBP and MAP responses. Genetic regions on chromosomes 3 and 11 may harbor important susceptibility loci for potassium sensitivity. Furthermore, the AGTR1 gene was a significant predictor of BP responses to potassium intake.

  15. Development and Demonstration of Manufacturing Processes for Fabricating Graphite/LARC 160 Polyimide Structural Elements.

    DTIC Science & Technology

    1981-12-01

    microporous mem - brane over the preform bleeder surface and secure in place, wrinkle-free, with pressure sensitive tape on the backside of the mandrel...0 ,1 - a)Q w ( w0O0 aO)W Q)W~ toIt o m 04 0r 0 0 - -0 - -. ’ F0 E-tO 000 F00 H0 OHp oi0 -o 0 0 H *H H H -A P to HH HZ *H HHP o~ 0I 4- m H 044 u It

  16. Discretized kinetic theory on scale-free networks

    NASA Astrophysics Data System (ADS)

    Bertotti, Maria Letizia; Modanese, Giovanni

    2016-10-01

    The network of interpersonal connections is one of the possible heterogeneous factors which affect the income distribution emerging from micro-to-macro economic models. In this paper we equip our model discussed in [1, 2] with a network structure. The model is based on a system of n differential equations of the kinetic discretized-Boltzmann kind. The network structure is incorporated in a probabilistic way, through the introduction of a link density P(α) and of correlation coefficients P(β|α), which give the conditioned probability that an individual with α links is connected to one with β links. We study the properties of the equations and give analytical results concerning the existence, normalization and positivity of the solutions. For a fixed network with P(α) = c/α q , we investigate numerically the dependence of the detailed and marginal equilibrium distributions on the initial conditions and on the exponent q. Our results are compatible with those obtained from the Bouchaud-Mezard model and from agent-based simulations, and provide additional information about the dependence of the individual income on the level of connectivity.

  17. Bistability and up/down state alternations in inhibition-dominated randomly connected networks of LIF neurons.

    PubMed

    Tartaglia, Elisa M; Brunel, Nicolas

    2017-09-20

    Electrophysiological recordings in cortex in vivo have revealed a rich variety of dynamical regimes ranging from irregular asynchronous states to a diversity of synchronized states, depending on species, anesthesia, and external stimulation. The average population firing rate in these states is typically low. We study analytically and numerically a network of sparsely connected excitatory and inhibitory integrate-and-fire neurons in the inhibition-dominated, low firing rate regime. For sufficiently high values of the external input, the network exhibits an asynchronous low firing frequency state (L). Depending on synaptic time constants, we show that two scenarios may occur when external inputs are decreased: (1) the L state can destabilize through a Hopf bifucation as the external input is decreased, leading to synchronized oscillations spanning d δ to β frequencies; (2) the network can reach a bistable region, between the low firing frequency network state (L) and a quiescent one (Q). Adding an adaptation current to excitatory neurons leads to spontaneous alternations between L and Q states, similar to experimental observations on UP and DOWN states alternations.

  18. Online Learning of Genetic Network Programming and its Application to Prisoner’s Dilemma Game

    NASA Astrophysics Data System (ADS)

    Mabu, Shingo; Hirasawa, Kotaro; Hu, Jinglu; Murata, Junichi

    A new evolutionary model with the network structure named Genetic Network Programming (GNP) has been proposed recently. GNP, that is, an expansion of GA and GP, represents solutions as a network structure and evolves it by using “offline learning (selection, mutation, crossover)”. GNP can memorize the past action sequences in the network flow, so it can deal with Partially Observable Markov Decision Process (POMDP) well. In this paper, in order to improve the ability of GNP, Q learning (an off-policy TD control algorithm) that is one of the famous online methods is introduced for online learning of GNP. Q learning is suitable for GNP because (1) in reinforcement learning, the rewards an agent will get in the future can be estimated, (2) TD control doesn’t need much memory and can learn quickly, and (3) off-policy is suitable in order to search for an optimal solution independently of the policy. Finally, in the simulations, online learning of GNP is applied to a player for “Prisoner’s dilemma game” and its ability for online adaptation is confirmed.

  19. Genome-Wide Association Study of White Blood Cell Count in 16,388 African Americans: the Continental Origins and Genetic Epidemiology Network (COGENT)

    PubMed Central

    Arepalli, Sampath; Britton, Angela; Chen, Zhao; Couper, David; Curb, J. David; Eaton, Charles B.; Fornage, Myriam; Grant, Struan F. A.; Harris, Tamara B.; Hernandez, Dena; Kamatini, Naoyuki; Keating, Brendan J.; Kubo, Michiaki; LaCroix, Andrea; Lange, Leslie A.; Liu, Simin; Lohman, Kurt; Meng, Yan; Mohler, Emile R.; Musani, Solomon; Nakamura, Yusuke; O'Donnell, Christopher J.; Okada, Yukinori; Palmer, Cameron D.; Papanicolaou, George J.; Patel, Kushang V.; Singleton, Andrew B.; Takahashi, Atsushi; Tang, Hua; Taylor, Herman A.; Taylor, Kent; Thomson, Cynthia; Yanek, Lisa R.; Yang, Lingyao; Ziv, Elad; Zonderman, Alan B.; Folsom, Aaron R.; Evans, Michele K.; Liu, Yongmei; Becker, Diane M.; Snively, Beverly M.; Wilson, James G.

    2011-01-01

    Total white blood cell (WBC) and neutrophil counts are lower among individuals of African descent due to the common African-derived “null” variant of the Duffy Antigen Receptor for Chemokines (DARC) gene. Additional common genetic polymorphisms were recently associated with total WBC and WBC sub-type levels in European and Japanese populations. No additional loci that account for WBC variability have been identified in African Americans. In order to address this, we performed a large genome-wide association study (GWAS) of total WBC and cell subtype counts in 16,388 African-American participants from 7 population-based cohorts available in the Continental Origins and Genetic Epidemiology Network. In addition to the DARC locus on chromosome 1q23, we identified two other regions (chromosomes 4q13 and 16q22) associated with WBC in African Americans (P<2.5×10−8). The lead SNP (rs9131) on chromosome 4q13 is located in the CXCL2 gene, which encodes a chemotactic cytokine for polymorphonuclear leukocytes. Independent evidence of the novel CXCL2 association with WBC was present in 3,551 Hispanic Americans, 14,767 Japanese, and 19,509 European Americans. The index SNP (rs12149261) on chromosome 16q22 associated with WBC count is located in a large inter-chromosomal segmental duplication encompassing part of the hydrocephalus inducing homolog (HYDIN) gene. We demonstrate that the chromosome 16q22 association finding is most likely due to a genotyping artifact as a consequence of sequence similarity between duplicated regions on chromosomes 16q22 and 1q21. Among the WBC loci recently identified in European or Japanese populations, replication was observed in our African-American meta-analysis for rs445 of CDK6 on chromosome 7q21 and rs4065321 of PSMD3-CSF3 region on chromosome 17q21. In summary, the CXCL2, CDK6, and PSMD3-CSF3 regions are associated with WBC count in African American and other populations. We also demonstrate that large inter-chromosomal duplications can result in false positive associations in GWAS. PMID:21738479

  20. Relationship of biomedical science content acquisition performance to students' level of PBL group interaction: are students learning during PBL group?

    PubMed

    Romito, Laura M; Eckert, George J

    2011-05-01

    This study assessed biomedical science content acquisition from problem-based learning (PBL) and its relationship to students' level of group interaction. We hypothesized that learning in preparation for exams results primarily from individual study of post-case learning objectives and that outcomes would be unrelated to students' group involvement. During dental curricular years 1 and 2, student-generated biomedical learning issues (LIs) were identified from six randomly chosen PBL cases. Knowledge and application of case concepts were assessed with quizzes based on the identified LIs prior to dissemination of the learning objectives. Students and facilitators were surveyed on students' level of group involvement for the assessed LI topics. Year 1 students had significantly higher assessment scores (p=0.0001). For both student classes, means were significantly higher for the recall item (Q1) than for the application item (Q2). Q1 scores increased along with the student's reported role for Year 1 (p=0.04). However, there was no relationship between the student's reported role and Q1 for Year 2 (p=0.20). There was no relationship between the student's reported role and Q2 for Year 1 (p=0.09) or Year 2 (p=0.19). This suggests that students' level of group involvement on the biomedical learning issues did not significantly impact students' assessment performance.

  1. Research Apprenticeships for Disadvantaged High Schooler (RADHS)

    DTIC Science & Technology

    1981-06-30

    Maestas , Director 0 ~ -~ 0(A ea 0 m. 0 L) CL wa’ I.-- - 4...Le) - 4u. -j.. 0 ’ Lii -= L-(. S - u 0o (1) Q. ) 0. 4- Lai _ S .. c tu -L 0 a) 0I. ’ 1 - 4-) CL 0.i 0 4-) c e..j 00C - E CA m) ~ ’ C. a) r_. Mi C > (1...8217 to. L 4-3WC0a E Q) =CL. 0i ’ *1’- W- 0 faa . Xu 4-) *4c U CO C- 4-l Li 4J 10 .0 C 0 c S - 0-’- o w U) ~ 00 ’a (1) 0i 2 C> - CO ’’ 4). C04- 0 S .-

  2. A path model for Whittaker vectors

    NASA Astrophysics Data System (ADS)

    Di Francesco, Philippe; Kedem, Rinat; Turmunkh, Bolor

    2017-06-01

    In this paper we construct weighted path models to compute Whittaker vectors in the completion of Verma modules, as well as Whittaker functions of fundamental type, for all finite-dimensional simple Lie algebras, affine Lie algebras, and the quantum algebra U_q(slr+1) . This leads to series expressions for the Whittaker functions. We show how this construction leads directly to the quantum Toda equations satisfied by these functions, and to the q-difference equations in the quantum case. We investigate the critical limit of affine Whittaker functions computed in this way.

  3. 27 CFR 19.957 - Instructions to compute bond penal sum.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Instructions to compute bond penal sum. 19.957 Section 19.957 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX... Fuel Use Bonds § 19.957 Instructions to compute bond penal sum. (a) Medium plants. To find the required...

  4. 17 CFR 10.5 - Computation of time.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Computation of time. 10.5 Section 10.5 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION RULES OF PRACTICE... computed is to be included unless it is a Saturday, a Sunday, or a legal holiday; in which event the period...

  5. 500 Contractors Receiving the Largest Dollar Volume of Prime Contract Awards for RDT&E (Research, Development, Test and Evaluation), Fiscal Year 1978.

    DTIC Science & Technology

    1978-01-01

    HEIGHT MASS FtA NEWTON MASS 317 I?r INDUSTRIAL ELECTRIC MOTORS INC S 9A0 9 WEST ALLIS WISCONSIN 960 3068 AFRODYNE RESEARCH INC s 1.07? W BEDFORD MASS...9,838 WATERTON COLORADO 1,766 PITTSFIELO MASS Z6.627 ORLANDO FLORIDA IT1,678 WEST LYNN MASS 18s.04b BALTIMORE MARYLAND 379 WILMINGTON MASS $69 IN...NEEDHAM MASS 11,.57 STRATFORD CONN 5q ,5A Q NEEDHAM HEIGHT MASS 4.0, 64f WINDSOR LOCKS rONN I.A62 WHITE SANDS MS NEW MEXICO 83 WEST PALM SFAC FLORIDA bR

  6. Alpha List of Prime Contract Awards. Oct 91 - Sep 92. FY 92. (Reichlmeter - Season All Industries Inc)

    DTIC Science & Technology

    1993-01-01

    11 0 1 b.4- 1 CL- 0 0 - V0- ~ - . - -II 0w- 0 0 0 0 0 0 0 Ii ’ 1 I O C 4 0 0 (D a0 - ( N 1,4 40 4 4 4 4 4 0 4 4 0 4 4 4coo0 400 it 1M (7 4 0 0 Ip -j...C.Q00000 0C0 k0 a010 00 000 C) N5 N 1-if Nf N IP -NN N NN 14P4NN NN N NN N N NI N NN N N NN’N NJ10Q-t- if 7 ,2ZZZZ ZZZZZZZZZZZZZZ2ZZZ ZZ zzz 4w 140000...0 0< 4 0ɜ 04 0ɜɜ 04=(0C R 2 2 Z z 22 Zzz 2 2 222 z PP P00-w P4 N 0 44 0 4 10wCo0mm < ca 0 iP 0 0 0 - P 0 0c c % U -4mi0 N m0 PIS 0-400 N 0

  7. Department of the Navy Justification of Estimates FY 1992/FY 1993 Budget Estimates Submitted to Congress February 1991, Operation and Maintenance, Navy. Book 3

    DTIC Science & Technology

    1991-02-01

    a O(%U v ot (UUGo 1a 1 0% fa ac(Ut . bo tic w W - El hi 400W0 4 0w0uw0 wD(OGOLm-4 94 9 0 N w w u c tv-M 41 9: u Q0. W W :3 C-L W W 41 W) ~ a) WD -4- 4C...fd E-4001 a).0 tic . >L 0L Er-4 ’-4’v to2 >0 (D 02>A o V* 0r El ’--20 to4L ~-02 0 >IV0 Pl-4 Z4’e420q 9: 00 󈧬ao >1 i to El0 41.- 02" " " L6i: U 1W"E...c’i0 a%0O C- . el 0.0 W bC~ 0 -4 04’ a .0-tC1 0 W >4 rc. -40𔃺 W%.4’ -4 ~- C;- ( l,2 >, r4)-󈧈 W 40 J 0%-.4 - en 0 4 a 4 E-..4 = U) V) V0 0 L 41M1

  8. Prime Contract Awards Alphabetically by Contractor, State or Country, and Place. Part 9 (Hewlett Packard Company, Foster City, California - International Bus MCHS Corp, Louisville, Kentucky), FY1991

    DTIC Science & Technology

    1991-01-01

    44 0 4 N in M 4 a amN LU-4 OJ4 00o O-4NNN00 04-7)07 0m ()0) 1-0 U0o -4 mwNO r NO N x QO 000 LU00000W( MOO5 XU0 £000 a. ] - -4 F6 .. .5n -.J4 J.4 mm4...4 NNa0 1-am ~a") Ia 4-. -4 - 4 -*** o Q o o ooQ00o00o--44- 01 D .C 1C w : am 1 C00-4 1 l I co -4 mmiN4f4N- .N 4-4- .4 III aCca 4 aa in 0 n 0 0 0 00...04NNMOCOMO -4-4 -.1 640 IIOf-N4.-0444000.40-..400 <mNOO4-40000000000>C C-4- < Ia 4 0 <C’) Is ZZIW a.LL~a.La. 0.A 60 < 4Ni to I IfO(-0(N40ml0ilOONt’. f6 -4 6

  9. Oceanographic Analyses and Forecasts for Fleet Support (Services and Codes). Revised.

    DTIC Science & Technology

    1967-08-01

    unit of thousands is omitted.) 11I SOUND VELOCITY PROFILE The SVP message form will normally follow the TD profile to which it pertains in the following...i ra 0 0 a 3’: VE C//3 000Q F- A E-4 =) 4-4 0.. 0- P4 C4 L) r. ~ N C)(D~ > a) CO C4 IHQ N E- .,1 0 r 4 4-4 V L 04 04 0 0 = rz - r- i r- 4(0 Ow ( (D

  10. All Prime Contract Awards by State or Country, Place, and Contractor. Part 5 (Vineburg, California-Wyoming, Delaware)

    DTIC Science & Technology

    1990-01-01

    4 a:: wi :t mo 400 N erntiofl0o~Nco cf),4In m in N It N O0) I I C) q N! 1 )-11uIto00 N qt 1- 0 0 0) 15.1 C: c 40 N Me o- -4 CV) 00 I M100 00 Nf 04 NCV ...00.-4 1 61 4 t wt it 4 q**- 0 nCV ) ..I)0)00 I- M m0Y) m0I00m0MCV00m000Y00mIn00Y00000m000000000) IL.4 (-4 NNINNNNNNNNN 00 00000C004- q- .. 4-4- 4 - 44...4N N ൰CV N N 4 .40 8&.NC40000 NCV )(’ am 000 N> in 24 Z.C’%> a EI*0 woo E E E E E 9 III - I Coc 1140 -i at 0 0 -mN 06* 00 Is40 10 V V 1L a. UI *6

  11. Geographic List of Prime Contract Awards. Oct 91 - Sep 92. FY92. (Naval Base Washington - Greenland)

    DTIC Science & Technology

    1993-01-01

    000 0 c3 -- q 4 inionO 00 Ocl in MEM < CO (71) 11 c’) cl) 0) on oil I < c> M (71 l" r., r- 1- 11 r-- 0 10 Q Cý c> Q c> 0 (01010 Coo c’) 10 c"I...0)0)))000)a)0M ) 41I1 I0ON1 It10. Dr if I 0)oN 1100.. .l > OHp I0ON 14 0f 0 0 0. Mi 0ON 110 < -0 - 0 I-t0 1I03 0ON 110 P-4 0 - 2f) : M0ON 1100 00: W...40D 0 0 me .-404H-4 0s NIV O IN i 0 --4 C me I 0-4- )I t mem (-, 0100) * o- a0 Z 0 ( 1 00-o4 If Z >-Ie On o m4 4)I( 004c4 Is -HOW 0( in -# 00.- it rZ

  12. An Application of Content Analysis to Determine Congressional Behavior in Relation to the Defense Budget

    DTIC Science & Technology

    1977-06-01

    4 (1 4J 4- r 4 JQ) C) wn 03 Z$ 4 1,4 - )t n 0 4H H- J> )- H( (D 00H 4J W0 ) U 44 )w09 ) C 0 HI4 H 0U 0S.Hr4Wa - S-i U00- 4 j )X:a 9. td 04 t 0 4 JJVW...W4E- 0d .04- 0() - 0 CA r Q-sm 4ww0 U000 Cpv to 0 4 0) 0.0 m (a 10-i 00 014 4 3UV u 1)0 0Uc2 0 02- 144 A: 40 9()0 O4’ w 20 C 04149> 0)" w -H u2 0) 04

  13. All Prime Contract Awards by State or Country, Place, and Contractor, FY 85. Part 15 (Altus, Oklahoma - Zelienople, Pennsylvania).

    DTIC Science & Technology

    1985-01-01

    Iso CM I m -4 0N 4 MNNNNNN"N-4-4 aN ION w O 40 UNNN liN 40.4 4 OR 60 4 14 .-4 -4 ..4 -4f -4 I-’ 1 0 0 0 0 0 0 0 0 0 -i aJC 0 4 1 4 i q--4-4--4 -- 4...4 azo azo ixN 0 .0 woo 000 0zo 01( C’) -I .4 0i~o x-0 0 4 N - ((0 04 03(0 ()I 1 -0 -4 0~00 x -0 0 04 " .(A 0 04 0.0 .4 0’( 4C I m i 41013 ə 3tr irn

  14. NNLO corrections to top-pair production at hadron colliders: the all-fermionic scattering channels

    NASA Astrophysics Data System (ADS)

    Czakon, Michal; Mitov, Alexander

    2012-12-01

    This is a second paper in our ongoing calculation of the next-to-next-to-leading order (NNLO) QCD correction to the total inclusive top-pair production cross-section at hadron colliders. In this paper we calculate the reaction qoverline{q}to toverline{t}+qoverline{q} which was not considered in our previous work on qoverline{q}to toverline{t}+X [1] due to its phenomenologically negligible size. We also calculate all remaining fermion-pair-initiated partonic channels q{q^' }} , q{{overline{q}}^' }} and qq that contribute to top-pair production starting from NNLO. The contributions of these reactions to the total cross-section for top-pair production at the Tevatron and LHC are small, at the permil level. The most interesting feature of these reactions is their characteristic logarithmic rise in the high energy limit. We compute the constant term in the leading power behavior in this limit, and achieve precision that is an order of magnitude better than the precision of a recent theoretical prediction for this constant. All four partonic reactions computed in this paper are included in our numerical program Top++. The calculation of the NNLO corrections to the two remaining partonic reactions, qgto toverline{t}+X and ggto toverline{t}+X , is ongoing.

  15. Searching for axion stars and Q-balls with a terrestrial magnetometer network

    DOE PAGES

    Jackson Kimball, D. F.; Budker, D.; Eby, J.; ...

    2018-02-08

    Light (pseudo-)scalar fields are promising candidates to be the dark matter in the Universe. Under certain initial conditions in the early Universe and/or with certain types of self-interactions, they can form compact dark-matter objects such as axion stars or Q-balls. Direct encounters with such objects can be searched for by using a global network of atomic magnetometers. It is shown that for a range of masses and radii not ruled out by existing observations, the terrestrial encounter rate with axion stars or Q-balls can be sufficiently high (at least once per year) for a detection. Furthermore, it is shown thatmore » a global network of atomic magnetometers is sufficiently sensitive to pseudoscalar couplings to atomic spins so that a transit through an axion star or Q-ball could be detected over a broad range of unexplored parameter space.« less

  16. Searching for axion stars and Q -balls with a terrestrial magnetometer network

    NASA Astrophysics Data System (ADS)

    Jackson Kimball, D. F.; Budker, D.; Eby, J.; Pospelov, M.; Pustelny, S.; Scholtes, T.; Stadnik, Y. V.; Weis, A.; Wickenbrock, A.

    2018-02-01

    Light (pseudo-)scalar fields are promising candidates to be the dark matter in the Universe. Under certain initial conditions in the early Universe and/or with certain types of self-interactions, they can form compact dark-matter objects such as axion stars or Q -balls. Direct encounters with such objects can be searched for by using a global network of atomic magnetometers. It is shown that for a range of masses and radii not ruled out by existing observations, the terrestrial encounter rate with axion stars or Q -balls can be sufficiently high (at least once per year) for a detection. Furthermore, it is shown that a global network of atomic magnetometers is sufficiently sensitive to pseudoscalar couplings to atomic spins so that a transit through an axion star or Q -ball could be detected over a broad range of unexplored parameter space.

  17. Searching for axion stars and Q-balls with a terrestrial magnetometer network

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jackson Kimball, D. F.; Budker, D.; Eby, J.

    Light (pseudo-)scalar fields are promising candidates to be the dark matter in the Universe. Under certain initial conditions in the early Universe and/or with certain types of self-interactions, they can form compact dark-matter objects such as axion stars or Q-balls. Direct encounters with such objects can be searched for by using a global network of atomic magnetometers. It is shown that for a range of masses and radii not ruled out by existing observations, the terrestrial encounter rate with axion stars or Q-balls can be sufficiently high (at least once per year) for a detection. Furthermore, it is shown thatmore » a global network of atomic magnetometers is sufficiently sensitive to pseudoscalar couplings to atomic spins so that a transit through an axion star or Q-ball could be detected over a broad range of unexplored parameter space.« less

  18. Have No PHEAR: Networks Without Identifiers

    DTIC Science & Technology

    2015-12-07

    packet processing, cryptography , or other computationally intensive func- tionality is present. This prevents, e.g., SDN-based onion routing from being...client registration protocol uses public key cryptography in its identity verification handshake. An attacker could exploit this by continually...and M. K. Wright. Timing Attacks in Low-Latency Mix-Based Systems. In A. Juels, editor, Proceedings of Financial Cryptography (FC ’04), pages 251–265

  19. Inverse association of vitamin D3 levels with lung cancer mediated by genetic variation.

    PubMed

    Haznadar, Majda; Krausz, Kristopher W; Margono, Ezra; Diehl, Christopher M; Bowman, Elise D; Manna, Soumen Kanti; Robles, Ana I; Ryan, Bríd M; Gonzalez, Frank J; Harris, Curtis C

    2018-06-01

    Vitamin D is an essential micronutrient required for normal physiological function and recognized for its role regulating calcium metabolism. Recent work is beginning to emerge demonstrating a role for vitamin D in chronic illnesses, such as cancer. Circulating serum levels of 25(OH)D 2/3 were quantitatively measured using sensitive ultraperformance liquid chromatography coupled to tandem mass spectrometry (UPLC-MS/MS) in 406 lung cancer cases and 437 population controls, while 1,25(OH) 2 D 2/3 levels were measured in a subset of 90 cases and 104 controls using the same method, from the NCI-MD case-control cohort. 25(OH)D 3 levels were inversely associated with lung cancer status across quartiles (Q2 vs. Q1: OR adjusted  = 0.5, 95% CI = 0.3-0.8; Q3 vs. Q1: OR adjusted  = 0.5, 95% CI = 0.3-0.8; Q4 vs. Q1: OR adjusted  = 0.5, 95% CI = 0.2-0.9; P trend  = 0.004). Levels of 1,25(OH) 2 D 3 were also inversely associated with lung cancer status (Q2 vs. Q1: OR adjusted  = 0.2, 95% CI = 0.03-0.7; Q3 vs. Q1: OR adjusted  = 0.1, 95% CI = 0.01-0.4; Q4 vs. Q1: OR adjusted  = 0.04, 95% CI = 0.01-0.3; P trend <0.0001). Although the observed trends were similar for the 25(OH)D 2 (P trend  = 0.08), no significant associations were seen between vitamin D 2 and lung cancer status. Additionally, genotyping of 296 SNPs in the same subjects resulted in findings that 27 SNPs, predominantly in CYP24A1 and VDR genes, were significantly associated with lung cancer status, affected mRNA expression, and modulated vitamin D levels. These findings suggest a protective role for vitamin D 3 in lung cancer, with similar trends but insignificant findings for D 2 . Vitamin D 3 levels appeared to be modulated by genetic variation in CYP24A1 and VDR genes. Additional research to illuminate the mechanism(s) through which vitamin D exacerbates effects against lung carcinogenesis is warranted. © 2018 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.

  20. Network survivability performance (computer diskette)

    NASA Astrophysics Data System (ADS)

    1993-11-01

    File characteristics: Data file; 1 file. Physical description: 1 computer diskette; 3 1/2 in.; high density; 2.0MB. System requirements: Mac; Word. This technical report has been developed to address the survivability of telecommunications networks including services. It responds to the need for a common understanding of, and assessment techniques for network survivability, availability, integrity, and reliability. It provides a basis for designing and operating telecommunication networks to user expectations for network survivability.

Some links on this page may take you to non-federal websites. Their policies may differ from this site.
Top