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Sample records for neurostimulation forty years

  1. Forty years of marburg virus.

    PubMed

    Slenczka, Werner; Klenk, Hans Dieter

    2007-11-15

    Forty years ago, in early August 1967, the first filovirus ever detected, Marburg virus, made its appearance in Europe, causing severe and often fatal hemorrhagic fever in laboratory workers in Marburg and Frankfurt and, about 4 weeks later, in Belgrade. The etiological agent was isolated and identified by the combined efforts of virologists in Marburg and Hamburg within the very short time of 3 months. Marburg was not the only town where the virus was isolated and identified for the first time, but most cases of infection occurred in Marburg.

  2. Forty years of TTG research

    NASA Astrophysics Data System (ADS)

    Moyen, Jean-François; Martin, Hervé

    2012-09-01

    TTGs (tonalite-trondhjemite-granodiorite) are one of the archetypical lithologies of Archaean cratons. Since their original description in the 1970s, they have been the subject of many studies and discussions relating to Archaean geology. In this paper, we review the ideas, concepts and arguments brought forward in these 40 years, and try to address some open questions — both old and new. The late 1960s and the 1970s mark the appearance of "grey gneisses" (TTG) in the scientific literature. During this period, most work was focused on the identification and description of this suite, and the recognition that it is a typical Archaean lithology. TTGs were already recognised as generated by melting of mafic rocks. This was corroborated during the next decade, when detailed geochemical TTG studies allowed us to constrain their petrogenesis (melting of garnet-bearing metamafic rocks), and to conclude that they must have been generated by Archaean geodynamic processes distinct from their modern counterparts. However, the geodynamic debate raged for the following 30 years, as many distinct tectonic scenarios can be imagined, all resulting in the melting of mafic rocks in the garnet stability field. The 1990s were dominated by experimental petrology work. A wealth of independent studies demonstrated that melting of amphibolites as well as of mafic eclogites can give rise to TTG liquids; whether amphibolitic or eclogitic conditions are more likely is still an ongoing debate. From 1990s onwards, one of the key questions became the comparison with modern adakites. As originally defined these arc lavas are reasonably close equivalents to Archaean TTGs. Pending issues largely revolve around definitions, as the name TTG has now been applied to most Archaean plutonic rocks, whether sodic or potassic, irrespective of their HREE contents. This leads to a large range of petrogenetic and tectonic scenarios; a fair number of which may well have operated concurrently, but are

  3. Forty years of canine vaccination.

    PubMed

    Appel, M J

    1999-01-01

    During the last 40 years vaccines have been developed that have greatly reduced the incidence of infectious diseases of dogs. In general, modified live products have been superior to inactivated vaccines for dogs. It can be expected that recombinant and/or DNA vaccines may dominate the market in the future. Although most vaccines on the market are safe and efficacious, there have been exceptions where disease was induced by vaccination or dogs were not protected. The failure of protection may in part be due to variations in individual vaccine batches. Only potency tests but not efficacy tests are required, which may not be sufficient. For example, a virus titer in a vaccine may be meaningless if the minimum protective dose is not known. Overattenuated virus (e.g., CDV-Ond or parvovirus in cat cells) may have a high titer in tissue culture but is not immunogenic. The question of frequency of vaccination of dogs should be addressed. Annual revaccinations for CDV, CPV, and CAV are probably not needed. However, it would be desirable to collect more data to support less frequent vaccinations. Annual immunization for bacterial diseases such as kennel cough, Lyme disease, and leptospirosis should continue. It also would be desirable to develop more oro/nasal vaccines, perhaps combined with newly developed vectors that are less likely to induce undesirable side effects that may be seen after parenteral vaccination. Finally a word of warning against homeopathic "nosodes" to replace tested canine vaccines. They will appear highly effective as long as the majority of dogs remain vaccinated. As soon as a nonvaccinated dog population is large enough to allow virulent agents to spread, disease outbreaks will occur and we will be back where we began 40 years ago.

  4. Forty Years with Emerging Viruses.

    PubMed

    Peters, C J

    2014-11-01

    I was raised in a middle-class family in West Texas and was lucky in my preparation through high school faculty, short government programs arising from the politics of Sputnik, inspiring high school mentors, and university training at a first-rate institution. My educational background led me to apply to medical school. With some financial aid, I managed to graduate and then obtain a first-class internal medicine residency at Parkland Hospital, where I acquired skills in discerning evaluation and treatment of patients with complicated diseases. In spite of a liking for and ability in clinical medicine, I entered the Public Health Service and worked for 5 years at the National Institutes of Health laboratory in Panama; there, I began to see the fascination of ecological impacts on virus transmission in nature and its spillover into human populations. I shifted my interests to these themes and their interaction with viral pathogenesis. At each stage of my career, I picked an institution to work where there were strong leaders and other inspiring scientists. I think the young scientist should choose the best available institution and one that offers a career direction that leads to a life where he or she awakens and cannot wait to arrive at his or her job-regardless of the details of each choice, the outcome will be a satisfied person who will contribute greatly to his or her chosen field.

  5. The first forty years, 1947-1987

    SciTech Connect

    Rowe, M.S.; Cohen, A.; Petersen, B.

    1987-01-01

    This report commemorates the fortieth anniversary of Brookhaven National Laboratory by representing a historical overview of research at the facility. The chapters of the report are entitled: The First Forty Years, Brookhaven: A National Resource, Fulfilling a Mission - Brookhaven's Mighty Machines, Marketing the Milestones in Basic Research, Meeting National Needs, Making a Difference in Everyday Life, and Looking Forward.

  6. Forty years from markers to genes.

    PubMed

    Mulley, John C

    2008-08-01

    There have been incredible advances made in human genetics over the past 40 years. I have set out in the next few pages to describe just some of these changes and to illustrate how they unfolded through my own experiences.

  7. Forty years of the war against Ebola.

    PubMed

    Zhang, Lei; Wang, Hao

    2014-09-01

    Humans have been fighting against the Ebola virus disease (EVD) since its first outbreak in 1976 in southern Sudan and Yambuku in Zaire which lies on the Ebola River. According to the data from the World Health Organization (WHO, 2014b), the first outbreak claimed 431 lives in 1976, and the disease awoke transiently in Sudan three years later and then disappeared for 15 years afterwards. Following that, large outbreaks appeared in 1995 in Zaire with 250 deaths of people, 2001-2002 in Uganda with 224 deaths, 2002-2003 in Congo with 128 deaths, and 2007 in Congo with 187 deaths. In 2014, the most severe and complicated outbreak swept through the West African countries having already taken 1069 lives, with the situation seeming to be out of control. To date, there have been 15 outbreaks in Africa, which have caused 4362 infected cases and claimed 2659 lives. The pandemics of Ebola show obvious independence from any season. Humans are generally susceptible to the Ebola virus without gender or age variation. The natural reservoir of the Ebola virus still remains unclear. During the past 40 years or so, the EVD disappeared after an outbreak in one region and erupted in another region without any warning. The difficulty in understanding the spreading pattern of Ebola was compared to that of the wave-particle duality of light.

  8. Nuclear chain reaction: forty years later

    SciTech Connect

    Sachs, R.G.

    1984-01-01

    The proceedings from a 1982 symposium 40 years after the first controlled nuclear chain reaction took place in Chicago covers four sessions and public discussion. The session covered the history of the chain reaction; peaceful uses in technology, medicine, and biological science; peaceful uses in power generation; and nuclear weapons control. Among the speakers were Eugene Wigner, Glenn Seaborg, Alvin Weinberg, and others who participated in the first chain reaction experiments. The proceedings reflect differences of opinion among the scientists as well as the general public. References, slides, and tables used to illustrate the individual talks are included with the papers.

  9. Reconstructing Forty Years of Landsat Observations

    NASA Astrophysics Data System (ADS)

    Meyer, D. J.; Dwyer, J. L.; Steinwand, D.

    2013-12-01

    In July 1972, NASA launched the Earth Resource Technology Satellite (ERTS), the first of what was to be the series of Earth-observing satellites we now know as the Landsat system. This system, originally conceived in the 1960's within the US Department of the Interior and US Geological Survey (USGS), has continued with little interruption for over 40 years, creating the longest record of satellite-based global land observations. The current USGS archive of Landsat images exceeds 4 million scenes, and the recently launched Landsat 8 platform will extend that archive to nearly 50 years of observations. Clearly, these observations are critical to the study of Earth system processes, and the interaction between these processes and human activities. However, the seven successful Landsat missions represent more of an ad hoc program than a long-term record of consistent observations, due largely to changing Federal policies and challenges finding an operational home for the program. Technologically, these systems evolved from the original Multispectral Scanning System (MSS) through the Thematic Mapper and Enhanced Thematic Mapper Plus (ETM+) systems, to the current Observational Land Imager (OLI) and Thermal Infrared Sensor (TIRS) systems. Landsat data were collected globally by a network of international cooperators having diverse data management policies. Much of the oldest data were stored on archaic media that could not be retrieved using modern media readers. Collecting these data from various sensors and sources, and reconstructing them into coherent Earth observation records, posed numerous challenges. We present here a brief overview of work done to overcome these challenges and create a consistent, long-term Landsat observation record. Much of the current archive was 'repatriated' from international cooperators and often required the reconstruction of (sometimes absent) metadata for geo-location and radiometric calibration. The older MSS data, some of which had

  10. The biology of memory: a forty-year perspective.

    PubMed

    Kandel, Eric R

    2009-10-14

    In the forty years since the Society for Neuroscience was founded, our understanding of the biology of memory has progressed dramatically. From a historical perspective, one can discern four distinct periods of growth in neurobiological research during that time. Here I use that chronology to chart a personalized and selective course through forty years of extraordinary advances in our understanding of the biology of memory storage.

  11. Divorce and death: forty years of the Charleston Heart Study.

    PubMed

    Sbarra, David A; Nietert, Paul J

    2009-01-01

    Forty years of follow-up data from the Charleston Heart Study (CHS) were used to examine the risk for early mortality associated with marital separation or divorce in a sample of more than 1,300 adults assessed on several occasions between 1960 and 2000. Participants who were separated or divorced at the start of the study evidenced significantly elevated rates of early mortality, and these results held after adjusting for baseline health status and other demographic variables. Being separated or divorced throughout the CHS follow-up window was one of the strongest predictors of early mortality. However, the excess mortality risk associated with separation or divorce was completely eliminated when participants who had ever experienced a marital separation or divorce during the study were compared with all other participants. These findings suggest that a key predictor of early death is the amount of time people live as separated or divorced. It is possible that the mortality risk conferred by marital dissolution is due to dimensions of personality that predict divorce as well as a decreased likelihood of future remarriage.

  12. Neurostimulation for chronic cluster headache

    PubMed Central

    Kaube, Holger

    2012-01-01

    Neurostimulation techniques for the treatment of primary headache syndromes, particularly of chronic cluster headache, have received much interest in recent years. Occipital nerve stimulation (ONS) has yielded favourable clinical results and, despite the limited numbers of published cases, is becoming a routine treatment for refractory chronic cluster headache in specialized centres. Meanwhile, other promising techniques such as spinal cord stimulation (SCS) or sphenopalate ganglion stimulation have emerged. In this article the current state of clinical research for neurostimulation techniques for chronic cluster headache is reviewed. PMID:22590481

  13. Looking Backward, Looking Forward: Forty Years of US Human Spaceflight Symposium

    NASA Technical Reports Server (NTRS)

    Garber, Stephen J. (Editor); Launius, Roger (Technical Monitor)

    2001-01-01

    This symposium reflects on forty years of U.S. Human Spaceflight, its role over the next four decades and beyond. The topics include: 1) Perspectives on the Past Forty Years of Human Spaceflight; 2) The Experience of Spaceflight; 3) Perspectives on the Next Forty Years of Human Spaceflight; and 4) The International Space Station and the Future of Human Spaceflight.

  14. Bilingualism in Paraguay: Forty Years after Rubin's Study

    ERIC Educational Resources Information Center

    Choi, Jinny K.

    2005-01-01

    Nearly 40 years have passed since the publication of Rubin's renowned study on Paraguayan bilingualism. The present study compares the results of surveys conducted in the years 2000-2001 with data from Rubin's 1960-1961 investigation. The main objective of this study is to examine the linguistic changes that have occurred in four decades and the…

  15. Diablo Valley College: The First Forty Years, 1949-1989.

    ERIC Educational Resources Information Center

    Mahan, Don; And Others

    An overview is provided of the 40-year history of Diablo Valley College (DVC), examining the educational ideals of the founders of the college and the changes in the goals of community college education in Central Contra Costa County, California. Part 1 sets the historical scene for the establishment of public two-year colleges nationally, in…

  16. Reconsidering Sputnik: Forty Years Since the Soviet Satellite

    NASA Technical Reports Server (NTRS)

    Launius, Roger D. (Editor)

    1997-01-01

    This collection of essays explore several broad themes: the Soviet Union and Sputnik, space and the international Geophysical Year, the immediate ramifications of Sputnik in the United States, and the significance of Sputnik throughout the world.

  17. In retrospect: Forty years of linking orbits to ice ages

    NASA Astrophysics Data System (ADS)

    Maslin, Mark

    2016-12-01

    In 1976, it was demonstrated that tiny wobbles in Earth's orbit led to the great ice-age cycles of the past few million years. This finding had wide implications for climate science and the details remain hotly debated today.

  18. Forty years on from Aerobee 150: a personal perspective.

    PubMed

    Pounds, Ken

    2002-09-15

    X-ray astronomy has evolved from a chance beginning 40 years ago to become a major branch of observational astronomy, underpinning a revolution in high-energy astrophysics. The intervening development can be seen in three phases, starting in the 1960s with a decade of pioneering exploration with sounding rockets, and consolidated by further discoveries with a series of dedicated small satellites, led by Uhuru, building up to NASA's HEAO-1 and Einstein Observatory missions in 1978-1981. The remaining years of the last century saw X-ray astronomy become a broad international effort with strong contributions from Europe and Japan balancing a temporary loss of momentum in the NASA programme. A brief account of those early years in X-ray astronomy is given, from a personal (UK) perspective, as an introduction to the review of the current status of the discipline, which was the subject of the Discussion Meeting.

  19. Brain Science and Teaching: A Forty-Year Personal History

    ERIC Educational Resources Information Center

    Kirby, Linda Faye

    2016-01-01

    This paper is the sharing of a record, the personal history of an educator pursuing an interest in knowledge of the brain. Over the years, this fascination sparked the idea to create a course for teachers based on brain science, with a twist. Certain course assignments would require teachers to interpret knowledge of the brain in the context of…

  20. Circulation Autumn: Some Thoughts on Forty Fulfillment Years.

    ERIC Educational Resources Information Center

    Cox, Brian

    1998-01-01

    Discusses some of the people and events that influenced academic journal publishing in the past 30-40 years and how this may affect the future. Topics considered include changes in printing technology, automation of accounting and subscriber information, economic considerations, library collection development and funding, and electronic journals.…

  1. Forty Years of Library Automation: A Personal Reflection

    ERIC Educational Resources Information Center

    Line, Maurice B.

    2006-01-01

    Purpose: To provide an overview of one person's involvement with computer systems in libraries over the last 40 years. Design/methodology/approach: Personal memories corroborated with published articles. Findings: There have been very many developments in libraries in a comparatively short period of time as a result of using computer systems, and…

  2. Canadian Women's Labor Force Behavior: A Forty Year Review.

    ERIC Educational Resources Information Center

    Fast, Janet E.; Skrypnek, Berna J.

    1994-01-01

    Describes three dimensions of labor force behavior: participation, attachment, and commitment. Presents a picture of trends in Canadian women's labor force behavior over the last 40 years using existing data. Discusses the implications of these trends for family life and corporate and public policy. (JOW)

  3. Reflections on Finally Becoming a Professor after Forty Years

    ERIC Educational Resources Information Center

    Watkins, J. Foster

    2016-01-01

    I wrote this reflective piece in 1999 as I was assuming my first full-time position as a professor with limited administrative responsibilities at the University of Alabama at Birmingham (UAB). After 30-plus years in administrative roles in higher education that provided the opportunity to teach on a part-time basis only, I quickly became aware of…

  4. Forty Years of Psychological and Psychiatric Selection of NASA Astronauts

    NASA Technical Reports Server (NTRS)

    Holland, Albert W.

    2000-01-01

    The purpose of this presentation is to chronicle the history and development of the psychological selection process for NASA astronauts. For over 40 years, astronaut applicants have undergone rigorous medical testing to qualify for candidacy. Psychological selection has an equally long history, dating back to 1958, when psychological requirements were established for astronauts during the Mercury program. However, for many years, psychological selection consisted of psychiatric screening for psychopathology. As we approach the day in which the first ISS crew will live and work in space for months at a time, it becomes clear that both the psychological criteria and the selection system to detect said criteria have changed. This presentation discusses the events that led to the current, dual-phase selection system that is used to select individuals into the astronaut corps. Future directions for psychological selection will also be addressed.

  5. Post-tuberculosis chronic empyema of the "forty years after".

    PubMed

    Mancini, P; Mazzei, L; Zarzana, A; Biagioli, D; Sposato, B; Croce, G F

    1998-01-01

    The authors present 110 cases of patients hospitalized in the last 5 years, with long-term disabling sequelae of pulmonary tuberculosis. Twelve out of them (= 10.9%) suffered from post-tuberculous chronic empyema, with an average latency period of 44.83 years between the acute tuberculous illness and the clinical manifestation of the empyema. Nine of the patients had been treated with collapsotherapy, induced by artificial intrapleural pneumothorax, 1 with thoracoplasty, and 2 only with late and inadequate anti-mycobacterial chemotherapy. Eleven patients (91.6%) also had a cutaneous fistula (7 cases) and/or a bronchopleural fistula (4 cases). The authors show how the issue of tuberculous sequelae is a significant not only from the numerical standpoint, but also for the seriousness of the caused pathological conditions, often posing problems for differential diagnosis. Moreover, they stress how tuberculosis should never be neglected or considered last in the differential diagnosis of empyema and pyopneumothorax.

  6. Forty years of vegetation change on the Missouri River Floodplain

    USGS Publications Warehouse

    Johnson, W.C.; Dixon, M.D.; Scott, M.L.; Rabbe, L.; Larson, G.; Volke, M.; Werner, B.

    2012-01-01

    Comparative inventories in 1969 and 1970 and in 2008 of vegetation from 30 forest stands downstream of Garrison Dam on the Missouri River in central North Dakota showed (a) a sharp decline in Cottonwood regeneration; (b) a strong compositional shift toward dominance by green ash; and (c) large increases in invasive understory species, such as smooth brome, reed canary grass, and Canada thistle. These changes, and others discovered during remeasurement, have been caused by a complex of factors, some related to damming (altered hydrologic and sediment regimes, delta formation, and associated wetdry cycles) and some not (diseases and expansion of invasive plants). Dominance of green ash, however, may be short lived, given the likelihood that the emerald ash borer will arrive in the Dakotas in 510 years, with potentially devastating effects. The prospects for recovery of this valuable ecosystem, rich in ecosystem goods and services and in American history, are daunting. ?? 2012 by American Institute of Biological Sciences. All rights reserved.

  7. Forty years of vegetation change on the Missouri River floodplain

    USGS Publications Warehouse

    Johnson, W. Carter; Dixon, Mark D.; Scott, Michael L.; Rabbe, Lisa; Larson, Gary; Volke, Malia; Werner, Brett

    2012-01-01

    Comparative inventories in 1969 and 1970 and in 2008 of vegetation from 30 forest stands downstream of Garrison Dam on the Missouri River in central North Dakota showed (a) a sharp decline in Cottonwood regeneration; (b) a strong compositional shift toward dominance by green ash; and (c) large increases in invasive understory species, such as smooth brome, reed canary grass, and Canada thistle. These changes, and others discovered during remeasurement, have been caused by a complex of factors, some related to damming (altered hydrologic and sediment regimes, delta formation, and associated wet-dry cycles) and some not (diseases and expansion of invasive plants). Dominance of green ash, however, may be short lived, given the likelihood that the emerald ash borer will arrive in the Dakotas in 5-10 years, with potentially devastating effects. The prospects for recovery of this valuable ecosystem, rich in ecosystem goods and services and in American history, are daunting.

  8. A Forty Year Odyssey in Metallo-Organic Chemistry.

    PubMed

    Nicholas, Kenneth M

    2015-07-17

    In this invited Perspective, I provide a personal account highlighting several of my group's research contributions in metallo-organic chemistry over the past 40 years. Our early work focused primarily in stoichiometric structure/reactivity of transition metal-organic compounds and their use in organic synthesis. More recent efforts have centered on the discovery and development of new metal-catalyzed organic reactions via reactive metal-organic intermediates. The major research findings that are described here include (1) propargyl-cobalt complexes as electrophilic agents for C-C and C-Nu coupling; (2) the activation of carbon dioxide by metal complexes; (3) metal-promoted C-H nitrogenation reactions; (4) oxo-metal catalyzed deoxygenation reactions; and (5) catalyst discovery via dynamic templating with substrate- and transition-state analogues.

  9. Forty-year appraisal of gastrinoma. Back to the future.

    PubMed Central

    Ellison, E C

    1995-01-01

    OBJECTIVE: The author analyzed potential survival determinants in gastrinoma to characterize a possible uniform staging system and to determine whether complete surgical resection improves expected survival. SUMMARY AND BACKGROUND DATA: Gastrinoma is an indolent yet malignant neuroendocrine tumor. The associated gastric acid hypersecretion can be controlled medically. Staging of gastrinoma is inconsistent and the role of surgical resection controversial. METHODS: Seventy-four patients with gastrinoma with a minimum 5-year follow-up were assessed. Cox's proportional hazards regression model was used to examine the association of risk factors with survival. RESULTS: The following factors had no effect on survival: age at diagnosis, sex, presence of lymph node metastases, associated multiple endocrine neoplasia, and method of ulcer treatment. The three unique determinants of survival were primary tumor size (relative risk, 1.534; p = 0.0005), liver metastases (relative risk, 2.947; p = 0.0209), and complete surgical resection (relative risk, 0.163; p = 0.0076). On the basis of these risk factors, a uniform staging system is proposed and predictive survival curves developed. CONCLUSIONS: The primary determinants of survival in gastrinoma are the size of the primary tumor and liver metastases. Complete surgical resection reduces mortality, regardless of other factors. PMID:7574931

  10. Forty years of research--its impact on dental practice.

    PubMed

    Mandel, I D

    1989-03-01

    With the multiple use of fluorides the philosophical basis of dental practice shifted from the restoration of the dentition to the prevention of the initiation of dental disease. In the United States, the profound impact on caries in children, with 50 per cent of the 5-17 year olds caries-free, has changed the relative distribution of the various dental services and the pattern of dental care. The child orientation has been superceded by greater attention to the restorative and other needs of the middle-aged and geriatric population. The research-generated insights into the role of plaque in the periodontal diseases and the wide-scale efforts to improve oral hygiene via plaque control have resulted in a marked reduction in gingivitis and manageable levels of periodontis in the employed population below the age of 65. More advanced disease can be treated more effectively because of new diagnostic procedures and new technologies as well as the use of anti-bacterial and anti-inflammatory agents. Major research advances in oral biology, oral medicine and oral diagnosis have extended both the depth and breadth of preventive dental practice. The scope of preventive dentistry now goes well beyond caries and periodontal disease to include: (1) injury, oro-facial defects, malocclusion and temporomandibular joint dysfunction; (2) oral mucosal lesions; (3) systemic diseases with oral manifestations and (4) hazards associated with dental practice. Dentistry is now being practised with an ordered set of priorities.

  11. Forty Years in Search of the Perfect Contact Lens

    PubMed Central

    Cavanagh, H. Dwight; Robertson, Danielle M.; Petroll, W. Matthew; Jester, James V.

    2010-01-01

    -preserved solutions (hydrogen peroxide). Clinical testing also shows that only peroxide solutions show significant disinfection capability against amoebic cysts. Further case-control studies to examine relative risk for infection by lens type and lens care solution are urgently needed. Conclusions Millions of patients are dependent on contact lenses for vision worldwide; and, over three decades lens use has increased while risk for lens-related infection has remained stubbornly unchanged. Unfortunately, recent introduction of a new generation of hyper oxygen transmissible lenses used with traditional MPS solutions has not lowered overall risks for lens-related infections; however, similar lenses used with non-preserved care solutions (peroxide) recently demonstrated no significant increases in PA binding in a one-year clinical trial. Collectively, these findings along with the urgent need for amoebic cysticidal disinfection, have led to a current recommendation to patients to use non-preserved (hydrogen peroxide) care solutions in soft lens wear. PMID:20622672

  12. Still "Unfinished Education": Latino Students Forty Years after the Mexican American Education Study

    ERIC Educational Resources Information Center

    Madrigal-Gonzalez, Lizely

    2012-01-01

    The onus of this dissertation was to evaluate the educational conditions of Mexican American students forty years after the "Mexican American Education Study" published a six-volume study detailing the findings of the "Mexican American Education Study" (1970-1974). The "MAES" study focused on five southwest states…

  13. Forty years abuse of baking soda, rhabdomyolysis, glomerulonephritis, hypertension leading to renal failure: a case report.

    PubMed

    Forslund, Terje; Koistinen, Arvo; Anttinen, Jorma; Wagner, Bodo; Miettinen, Marja

    2008-01-01

    We present a patient who had ingested sodium bicarbonate for treatment of alcoholic dyspepsia during forty years at increasing doses. During the last year he had used more than 50 grams daily. He presented with metabolic alkalosis, epileptic convulsions, subdural hematoma, hypertension and rhabdomyolysis with end stage renal failure, for which he had to be given regular intermittent hemodialysis treatment. Untreated hypertension and glomerulonephritis was probably present prior to all these acute incidents. Examination of the kidney biopsy revealed mesangial proliferative glomerulonephritis and arterial wall thickening causing nephrosclerosis together with interstitial calcinosis. The combination of all these pathologic changes might be responsible for the development of progressive chronic renal failure ending up with the need for continuous intermittent hemodialysis treatment.

  14. Forty Years Abuse of Baking Soda, Rhabdomyolysis, Glomerulonephritis, Hypertension Leading to Renal Failure: A Case Report

    PubMed Central

    Forslund, Terje; Koistinen, Arvo; Anttinen, Jorma; Wagner, Bodo; Miettinen, Marja

    2008-01-01

    We present a patient who had ingested sodium bicarbonate for treatment of alcoholic dyspepsia during forty years at increasing doses. During the last year he had used more than 50 grams daily. He presented with metabolic alkalosis, epileptic convulsions, subdural hematoma, hypertension and rhabdomyolysis with end stage renal failure, for which he had to be given regular intermittent hemodialysis treatment. Untreated hypertension and glomerulonephritis was probably present prior to all these acute incidents. Examination of the kidney biopsy revealed mesangial proliferative glomerulonephritis and arterial wall thickening causing nephrosclerosis together with interstitial calcinosis. The combination of all these pathologic changes might be responsible for the development of progressive chronic renal failure ending up with the need for continuous intermittent hemodialysis treatment. PMID:24179353

  15. Bilateral Diabetic Knee Neuroarthropathy in a Forty-Year-Old Patient

    PubMed Central

    Gallusser, Nicolas; Borens, Olivier

    2016-01-01

    Diabetic osteoarthropathy is a rare cause of neuropathic joint disease of the knee; bilateral involvement is even more exceptional. Diagnosis is often made late due to its unspecific symptoms and appropriate surgical management still needs to be defined, due to lack of evidence because of the disease's low incidence. We report the case of a forty-year-old woman with history of diabetes type I who developed bilateral destructive Charcot knee arthropathy. Bilateral total knee arthroplasty was performed in order to achieve maximal functional outcome. Follow-up was marked by bilateral tibial periprosthetic fractures treated by osteosynthesis with a satisfactory outcome. The diagnosis of Charcot arthropathy should always be in mind when dealing with atraumatic joint destruction in diabetic patients. Arthroplasty should be considered as an alternative to arthrodesis in bilateral involvement in young patients. PMID:27668112

  16. Forty Years of E/PO: Can You Have it All? (Invited)

    NASA Astrophysics Data System (ADS)

    Reiff, P. H.

    2013-12-01

    In forty years of education and public outreach (E/PO), 25 years of which have been funded by various NSF and NASA programs, several lessons (some tough) have been learned. We have done teacher workshops, teacher semester-long courses, student summer programs, outreach fairs and exhibits, and generally the response of the participants has been very high. Generally the longer programs reach fewer people but in greater depth and impact; the shorter programs reach more, but with lesser depth. This paper shows some of the statistics of learning in our various venues, include teacher courses, online material, and planetarium shows. We also performed an online survey of users of NASA materials and contrasted with a random group of 144 adults. We find that teachers and museum educators have nearly all been "significantly" or "changed my life" impacted by NASA educational materials, and even 24% of the general public have as well, with 14% of the general public reporting that NASA encouraged them to study STEM and go into STEM careers. Virtually all said that NASA should continue producing educational materials. Some of the stumbling blocks include: the difficulty of obtaining funds, the general lack of recognition for outreach in tenure decisions, the difficulty of trying to keep active in research while also active in outreach; and the general problem of "having a life" while juggling many responsibilities. Yet it is worth it!

  17. A case study of systemic curricular reform: A forty-year history

    NASA Astrophysics Data System (ADS)

    Laubach, Timothy Alan

    What follows is a description of the development of a particular inquiry-based elementary school science curriculum program and how its theoretical underpinnings positively influenced a school district's (K-12) science program and also impacted district- and state-wide curriculum reform initiatives. The district's science program has evolved since the inception of the inquiry-based elementary school science curriculum reform forty years ago. Therefore, a historical case study, which incorporated grounded theory methodology, was used to convey the forty-year development of a science curriculum reform effort and its systemic influences. Data for this study were collected primarily through artifacts, such as technical and non-technical documents, and supported and augmented with interviews. Fifteen people comprised the interview consortium with professional responsibilities including (a) administrative roles, such as superintendents, assistant superintendents, principals, and curriculum consultants/coordinators; (b) classroom roles, such as elementary and secondary school teachers who taught science; (c) partnership roles, such as university faculty who collaborated with those in administrative and classroom positions within the district; and (d) the co-director of SCIS who worked with the SCIS trial center director. Data were analyzed and coded using the constant comparative method. The analysis of data uncovered five categories or levels in which the curriculum reform evolved throughout its duration. These themes are Initiation, Education, Implementation, Confirmation, and Continuation. These five categories lead to several working hypotheses that supported the sustaining and continuing of a K-12 science curriculum reform effort. These components are a committed visionary; a theory base of education; forums promoting the education of the theory base components; shared-decision making; a university-school partnership; a core group of committed educators and teachers

  18. Forty-Five Years of Civil Litigation Against Canadian Psychiatrists: An Empirical Pilot Study

    PubMed Central

    Luther, Glen; Gutheil, Thomas G.

    2016-01-01

    Objectives: To extract the themes pertaining to prudent psychiatric practice from written court judgments in Canada. Methods: We searched the medical and legal literature for cases involving civil litigation against Canadian psychiatrist and reviewed all available written judgments. We completed a thematic analysis of the civil actions against psychiatrists as conveyed by those written court judgments. We classified the cases according to the disposal status and the essential lessons from the decisions on standard of care and practice by Canadian psychiatrists. Results: Forty such cases were identified as involving psychiatrists over a 45-year period. A subgroup included those dealing with limitation periods and disclosure applications. Thirty of the 40 cases (75%) were decided in favour of the defendant psychiatrists, including 2 dismissed for running over the limitation period. The cases that actually went to trial suggest that documentation and obtaining second opinions are protective against claims of negligence. Inpatient cases resulting in successful litigation against psychiatrists involved fatal outcomes, but not all fatal outcomes led to successful litigation. Conclusions: The key lessons from these cases are the importance and relevance of regular best clinical practices, such as documentation, obtaining second opinions, following guidelines, and balancing competencies in the expert and manager or advocate roles. Incorporating these practices should allay concerns about litigation against psychiatrists. PMID:27253702

  19. Arteriovenous malformations of the brain in children: a forty year experience.

    PubMed

    Kondziolka, D; Humphreys, R P; Hoffman, H J; Hendrick, E B; Drake, J M

    1992-02-01

    Despite the great capacity for the pediatric brain to recover from stroke, the morbidity and mortality in children who harbor an arteriovenous malformation (AVM) remains high. This study examines the clinical data and management experience with 132 patients with brain AVM from 1949 to 1989. Although the high tendency for a childhood AVM to present with hemorrhage (79%) remained constant for the forty year study period, the associated morbidity and mortality of hemorrhage changed. The mortality rate from hemorrhage for the entire series was 25%, which was reduced from 39% to 16% after the introduction of computed tomography. The mortality from AVM hemorrhage since 1975 was dependent on location; 8 of 14 patients (57%) with a cerebellar AVM died from hemorrhage while only 2 of 44 patients (4.5%) with a cerebral hemisphere AVM died (p less than 0.0001). Sixteen children (12%) presented with a chronic seizure disorder. Surgical excision of the malformation resulted in complete seizure control off anti-convulsant medication in 73% of patients. Although 21% of patients were treated non-operatively (many with terminal poor-grade hemorrhage), 79% had a surgical procedure with total AVM excision achieved in 70 patients (53.1%). Complete AVM resection was followed by a normal neurological outcome in 47 children (67%). Most partial excisions (n = 9) and clipping of feeding arteries (n = 7) were performed in the early years of this study, and did not provide protection from rehemorrhage. Although conservative management has been advocated for selected non-hemorrhagic AVMs, we conclude that essentially all children with an AVM should be treated in order to eliminate the risk of hemorrhage.(ABSTRACT TRUNCATED AT 250 WORDS)

  20. Neurostimulation for Primary Headache Disorders

    PubMed Central

    Schwedt, Todd J.

    2013-01-01

    Neurostimulation has emerged as a potential treatment option for patients with chronic, disabling, intractable primary headache disorders. Although safety and efficacy data are limited in quantity, there is accumulating experience with the use of peripheral nerve stimulation for the treatment of intractable occipital neuralgia, cluster headache, migraine, and less common headache disorders. Deep brain stimulation has been used to treat intractable chronic cluster headache and short-lasting unilateral neuralgiform headache with conjunctival injection and tearing. This article discusses the theorized mechanisms of action of these novel treatment modalities and summarizes current knowledge regarding safety and efficacy of neurostimulation for the treatment of headache. PMID:19268032

  1. Characterization of Forty Seven Years of Particulate Chemical Composition in the Finnish Arctic

    NASA Astrophysics Data System (ADS)

    Laing, James

    Forty seven years of weekly total suspended particle filters collected at Kevo, Finland from October 1964 through 2010 by the Finnish Meteorological Institute were analyzed for near-total trace elements, soluble trace elements, black carbon (BC), and major ions and methane sulfonic acid (MSA). Kevo is located in Northern Finland, 350 km north of the Arctic Circle. The samples from 1964-1978 were collected with Whatman 42 cellulous filters and the samples from 1979-2010 collected on Whatman GF/A glass-fiber filters. A portion of the filters was microwave acid-digested (ad) and analyzed for near-total trace elements were determined by inductively coupled plasma mass spectrometry (ICP-MS). Another portion was water extracted (we) and analyzed for soluble trace elements by ICP-MS and ionic species by ion chromatography (IC). Black carbon (BC) was determined using optical and thermal optical techniques at SUNY Albany. A clear seasonal trend with winter/spring maxima and summer minima is observed for most species attributed to enhanced transport of pollutants from anthropogenic mid-latitude sources to the Arctic in the winter and early spring. Compared to more remote Arctic sampling sites, species of anthropogenic origin (V, Co, Cu, Ni, As, Cd, Pb, SO4) have significantly higher concentrations and a less pronounced seasonality. High concentrations of Cu (14.1 ng/m3), Ni (0.97 ng/m3), and Co (0.04 ng/m3) indicate the influence of non-ferrous metal smelters on the Kola Peninsula, although Cu unexpectedly did not correlate with Ni or Co. Ni and Co were highly correlated. Significant long-term decreasing trends were detected for most species. All constituents except Sn-ad, Re-ad, Sn-we, Mo-we, V-we, have significant (p < 0.001) decreasing trends from 1964-2010. The largest decreases were Sb (-3.90 %/yr), Pb (-3.87 %/yr), Mn (-3.45 %/yr), Cd (-3.42 %/yr), and Ca (-3.13 %/yr ). As, Pb, and Cd concentrations at Kevo were consistent with the reported time-trends of European

  2. Neurostimulation for traumatic brain injury.

    PubMed

    Shin, Samuel S; Dixon, C Edward; Okonkwo, David O; Richardson, R Mark

    2014-11-01

    Traumatic brain injury (TBI) remains a significant public health problem and is a leading cause of death and disability in many countries. Durable treatments for neurological function deficits following TBI have been elusive, as there are currently no FDA-approved therapeutic modalities for mitigating the consequences of TBI. Neurostimulation strategies using various forms of electrical stimulation have recently been applied to treat functional deficits in animal models and clinical stroke trials. The results from these studies suggest that neurostimulation may augment improvements in both motor and cognitive deficits after brain injury. Several studies have taken this approach in animal models of TBI, showing both behavioral enhancement and biological evidence of recovery. There have been only a few studies using deep brain stimulation (DBS) in human TBI patients, and future studies are warranted to validate the feasibility of this technique in the clinical treatment of TBI. In this review, the authors summarize insights from studies employing neurostimulation techniques in the setting of brain injury. Moreover, they relate these findings to the future prospect of using DBS to ameliorate motor and cognitive deficits following TBI.

  3. Non-invasive antidromic neurostimulation: a simple effective method for improving bladder storage.

    PubMed

    Walsh, I K; Thompson, T; Loughridge, W G; Johnston, S R; Keane, P F; Stone, A R

    2001-01-01

    Patients with intractably diminished bladder storage function are encountered frequently by neurourologists, occasionally requiring reconstructive surgery for appropriate resolution. Although sacral neuromodulation is a recognized effective therapeutic modality, present techniques are technically demanding, invasive, and expensive. This study investigated the effect of non-invasive third sacral nerve (S3) stimulation on bladder activity during filling cystometry. One hundred forty-six patients underwent standard urodynamic filling cystometry that was then immediately repeated. Patients in the study group (n = 74) received antidromic transcutaneous sacral neurostimulation during the second fill and the control group (n = 72) underwent a second fill without neurostimulation. A statistically significant increase in bladder storage capacity without a corresponding rise in detrusor pressure was observed in the neurostimulated patients. This improvement in functional capacity is an encouraging finding that further supports the use of this non-invasive treatment modality in clinical practice.

  4. 4R Water quality impacts: An assessment and synthesis of forty years of drainage nitrogen losses

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The intersection of agricultural drainage and nutrient mobility in the environment has led to multi-scale water quality concerns. This work reviewed and quantitatively analyzed nearly 1300 site-years of drainage nitrogen load data to develop a more comprehensive understanding of the impacts of 4Rs ...

  5. Forty Years on: Presidential Address to the History of Education Society, London, 4 November 2006

    ERIC Educational Resources Information Center

    McCulloch, Gary

    2007-01-01

    This paper, based on the author's presidential address to the History of Education Society in November 2006, explores aspects of continuity and change over the past 40 years with particular reference to educational reform and the development of the History of Education Society itself. It assesses the significance of the work of the playwright Alan…

  6. FORTY YEARS OF SCHOOL PLANT DISSERTATIONS. A REVIEW WITH SUGGESTIONS FOR FUTURE RESEARCH.

    ERIC Educational Resources Information Center

    CLASEN, ROBERT E.

    A BIBLIOGRAPHIC REVIEW OF PUBLISHED AND UNPUBLISHED DISSERTATIONS RELATED TO SCHOOL PLANTS IS COMPILED BY YEARS BEGINNING WITH STUDIES PRODUCED IN 1921 AND IS CROSS INDEXED BY TOPIC. IT REVIEWS THE SCHOOL PLANT PROBLEMS MOST INVESTIGATED BY STUDENTS. A BRIEF HISTORY OF SCHOOL BUILDING DEVELOPMENT IS PRESENTED IN LIGHT OF CORRESPONDING ECONOMIC AND…

  7. Forty Years of Finnish Pre-School Education: The Development of Curricula between 1972 and 2000

    ERIC Educational Resources Information Center

    Turunen, Tuija A.; Maatta, Kaarina; Uusiautti, Satu

    2012-01-01

    Since 2001 in Finland, all six year olds have had the right to free pre-school education, and almost all pre-school-aged children take advantage of this opportunity. The purpose of this article is to dissect the development of Finnish pre-school education curricula within the societal context and within the changes in trends of curriculum planning…

  8. Forty Years Of Artificial Selection In U.S. Holstein Cattle Had Genome-wide Signatures

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Genome signatures of 40 years of artificial selection in U.S. Holstein cattle were identified by comparing allele frequencies and extended haplotype homozygosity in a Holstein resource population composed of a contemporary group, a group born in 1975-1985, and a group unselected since 1964. Results ...

  9. Past, Present and Future: Forty Years of Revista Mexicana de Astronomia y Astrofisica

    NASA Astrophysics Data System (ADS)

    Allen, Christine; Torres-Peimbert, Silvia

    2015-08-01

    We cast a retrospective view on 40 years of publishing the Revista Mexicana de Astronomía y Astrofísica, founded in 1974. The journal is peer-reviewed, has appeared regularly since its foundation, and continues to attract original research papers, mostly by Mexican and Latin American authors. We share some musings about the future of our journal, in view of recent developments in the scientific publishing field.

  10. Forty-five Years of e{sup +}e{sup -} Annihilation Physics: 1956 to 2001

    DOE R&D Accomplishments Database

    Richter, B.

    1984-08-01

    The history of e{sup +}e{sup -} physics in the 1950's and 1960's is reviewed, followed by some highlights of the spectacular discoveries in e{sup +}e{sup -} annihilation made during the 1970's. The consolidation of knowledge during the last few years is summarized. Some predictions are made for the field of e{sup +}e{sup -} physics for the next decade and beyond. (LEW)

  11. Optic Nerve Head Parameters in a Turkish Population Over Forty Years of Age

    PubMed Central

    Niyaz, Leyla; Yıldırım, Nilgün; Musmul, Ahmet

    2016-01-01

    Objectives: To evaluate the optic disc area and cup area in a normal population over 40 years of age. Materials and Methods: This prospective study was performed in Eskişehir. Fundus photographs were obtained using a nonmydriatic fundus camera. Planimetric measurements of the optic disc and cup area were performed with VK-2 digital imaging software. Optic nerve parameters were then compared between sex and age groups. Results: A total of 3,038 subjects were evaluated. Mean age was 56.6±10.4 years (range 40-91 years). The median disc area of the subjects was 2.87 (2.53-3.23) mm2 in the right eyes and 2.89 (2.55-3.25) mm2 in the left eyes (p<0.001). The median cup area of the subjects was 0.46 mm2 (0.33-0.64 mm2) in the right eyes and 0.44 mm2 (0.33-0.61 mm2) in the left eyes (p<0.001). The differences in disc and cup area between male and female subjects were not statistically significant (p>0.05). Conclusion: We report the normal distribution of disc area and cup area measurements and their association with age and sex. PMID:28058153

  12. Forty-five years of open plan office experience: An unusual case study

    NASA Astrophysics Data System (ADS)

    Paoletti, Dennis A.

    2005-09-01

    The open plan office design concept has been around for at least 45 years. Through research, design, and practical experience, the basic concepts and parameters that impact acoustics and speech privacy have been fairly well developed and documented. The psychological aspects of human response and expectation to open plan environments, and the conceptual designs that emerge from the architect and interior designers are frontiers that still allow for ongoing study. A large open plan project completed during the dot-com bubble allowed an opportunity to design and experience an unusual open plan environment that utilized exposed sound masking system loudspeakers and minimal sound absorption.

  13. Forty Years of Dengue Surveillance at a Tertiary Pediatric Hospital in Bangkok, Thailand, 1973-2012.

    PubMed

    Nisalak, Ananda; Clapham, Hannah E; Kalayanarooj, Siripen; Klungthong, Chonticha; Thaisomboonsuk, Butsaya; Fernandez, Stefan; Reiser, Julia; Srikiatkhachorn, Anon; Macareo, Louis R; Lessler, Justin T; Cummings, Derek A T; Yoon, In-Kyu

    2016-06-01

    Long-term observational studies can provide valuable insights into overall dengue epidemiology. Here, we present analysis of dengue cases at a pediatric hospital in Bangkok, Thailand, during a 40-year period from 1973 to 2012. Data were analyzed from 25,715 hospitalized patients with laboratory-confirmed dengue virus (DENV) infection. Several long-term trends in dengue disease were identified including an increase in mean age of hospitalized cases from an average of 7-8 years, an increase after 1990 in the proportion of post-primary cases for DENV-1 and DENV-3, and a decrease in the proportion of dengue hemorrhagic fever and dengue shock syndrome cases in primary and post-primary cases over time. Exploratory mechanistic analysis of these observed trends considered changes in diagnostic methods, demography, force of infection, and Japanese encephalitis vaccination as possible explanations. Thailand is an important setting for studying DENV transmission as it has a "mature" dengue epidemiology with a strong surveillance system in place since the early 1970s. We characterized changes in dengue epidemiology over four decades, and possible impact of demographic and other changes in the human population. These results may inform other countries where similar changes in transmission and population demographics may now or may soon be occurring.

  14. Forty years of 90Sr in situ migration: importance of soil characterization in modeling transport phenomena.

    PubMed

    Fernandez, J M; Piault, E; Macouillard, D; Juncos, C

    2006-01-01

    In 1960 experiments were carried out on the transfer of (90)Sr between soil, grapes and wine. The experiments were conducted in situ on a piece of land limited by two control strips. The (90)Sr migration over the last 40 years was studied by performing radiological and physico-chemical characterizations of the soil on eight 70 cm deep cores. The vertical migration modeling of (90)Sr required the definition of a triple layer conceptual model integrating the rainwater infiltration at constant flux as the only external factor of influence. Afterwards the importance of a detailed soil characterization for modeling was discussed and satisfactory simulation of the (90)Sr vertical transport was obtained and showed a calculated migration rate of about 1.0 cm year(-1) in full agreement with the in situ measured values. The discussion was regarding some of the key parameters such as granulometry, organic matter content (in the Van Genuchten parameter determination), Kd and the efficient rainwater infiltration. Besides the experimental data, simplifying assumptions in modeling such as water-soil redistribution calculation and factual discontinuities in conceptual model were examined.

  15. The ODAS Italia 1 buoy: More than forty years of activity in the Ligurian Sea

    NASA Astrophysics Data System (ADS)

    Canepa, Elisa; Pensieri, Sara; Bozzano, Roberto; Faimali, Marco; Traverso, Pierluigi; Cavaleri, Luigi

    2015-06-01

    The Ligurian Sea plays a relevant role in driving both the circulation of the Western Mediterranean Sea and the weather and climate of the area. In order to better understand the peculiarities of this basin, the Oceanographic Data Acquisition System (ODAS) Italia 1 buoy was developed and deployed in the early '70s. Throughout the years, the buoy has been fitted with updated measuring and data acquiring systems. Since 2003 the buoy has been part of the Mediterranean Moored Multi-sensor Array network of fixed open ocean observatories with the W1-M3A identifier and presently constitutes one of the Mediterranean sites of the European FixO3 network. Recently, a deep-ocean sub-surface mooring line was, and is, deployed close to it in relation to specific projects. This multidisciplinary observing system is able to perform both long-term operational and ad-hoc monitoring from the lower atmosphere to the deep ocean. It is used for analysis of air-sea interaction processes, study of the physical proprieties of the water column, bio-geo-chemical monitoring of the sea, meteorological and oceanographic model evaluation, calibration of remotely sensed measurements, and development of innovative marine monitoring technologies. After reporting some historical notes and the description of the observing system, this paper summarises and reviews the main oceanographic and atmospheric studies performed during the last 15 years using the data acquired on board.

  16. Forty years of inoculating seedlings with truffle fungi: past and future perspectives.

    PubMed

    Murat, Claude

    2015-01-01

    The first commercialization of seedlings inoculated with truffle fungi occurred in 1973. Over the last 40 years, considerable progress has been made relative to quality control for inoculated seedlings. A recently published paper by Andrés-Alpuente and colleagues (Mycorrhiza 24:29-37, 2014) reviewed and tested the different methods of mycorrhization assessment currently used in Europe. The aim of this paper is to augment their findings by adding information to the discussion about the most important steps in seedling quality control. Additionally, the history of seedlings inoculated with truffles, procedures currently used in France for seedling control quality, and a reflection on future research aimed at increasing truffle production will be presented.

  17. [The development of Rein van Bemmelens (1904-1983) undation theory: forty years of Dutch geology].

    PubMed

    Barzilay, Willemjan

    2009-01-01

    The Dutch geologist Rein van Bemmelen was the greatest opponent of plate tectonics in The Netherlands. He lived and worked during an important period in the history of earth sciences. He had studied geology when Wegeners theory was introduced and enthusiastically received in the Netherlands and he worked as a geologists during the period in which, after Wegeners theory was rejected in The Netherlands, several Dutch geologists came with their own theories to explain the origin of continents and oceans and in which plate tectonics was introduced in The Netherlands. He had proposed his own theory, the undation theory, at the beginning of the 1930s and kept on developing it during the following years. He continued to do so until his death in 1983. The history of the undation theory thus sheds light on the history of geology in The Netherlands. I will trace the history of geology in The Netherlands using Rein van Bemmelen and his undation theory as a lens.

  18. A career in culture and psychiatry research: reflections on forty-plus years.

    PubMed

    Beiser, Morton

    2011-04-01

    The report chronicles a 44-year career in cultural psychiatry spent at Duke, Cornell, Harvard, the University of British Columbia, the University of Toronto, and Ryerson Universities. It describes my studies in a rural community in Nova Scotia, in traditional villages in Senegal, West Africa, on Canadian First Nations reserves and American Indian reservations, in refugee camps in Southeast Asia, among immigrant and refugee communities in Canada, in Ethiopia, and in Israel. The report summarizes major findings resulting from these research efforts, and discusses contributions to theory as well as potential implications for practice as well as policy. The article concludes with reflections about the present state of cultural psychiatry, raises concerns about where the field seems to be in danger of going wrong, and offers suggestions about what needs to be done next.

  19. Forty-Year Calibrated Record of Earth-Surface Reflected Radiance from Landsat: A Review

    NASA Technical Reports Server (NTRS)

    Markham, Brian; Helder, Dennis

    2011-01-01

    Sensors on Landsat satellites have been collecting images of the Earth's surface for nearly 40 years. These images have been invaluable for characterizing and detecting changes in the land cover and land use of the world. Although initially conceived as primarily picture generating sensors, even the early sensors were radiometrically calibrated and spectrally characterized prior to launch and incorporated some capabilities to monitor their radiometric calibration once on orbit. Recently, as the focus of studies has shifted to monitoring Earth surface parameters over significant periods of time, serious attention has been focused toward bringing the data from all these sensors onto a common radiometric scale over this 40-year period. This effort started with the most recent systems and then was extended back in time. Landsat-7 ETM+, the best-characterized sensor of the series prior to launch and once on orbit, and the most stable system to date, was chosen to serve as the reference. The Landsat-7 project was the first of the series to build an image assessment system into its ground system, allowing systematic characterization of its sensors and data. Second, the Landsat-5 TM (still operating at the time of the Landsat-7 launch and continues to operate) calibration history was reconstructed based on its internal calibrator, vicarious calibrations, pseudo-invariant sites and a tie to Landsat-7 ETM+ at the time of the commissioning of Landsat-7. This process was performed in two iterations: the earlier one relied primarily on the TM internal calibrator. When this was found to have some deficiencies, a revised calibration was based more on pseudo-invariant sites, though the internal calibrator was still used to establish the short-term variations in response due to icing build up on the cold focal plane. As time progressed, a capability to monitor the Landsat-5 TM was added to the image assessment system. The Landsat-4 TM, which operated from 1982-1992, was the third

  20. A marriage full of surprises: forty-five years living with glutamate dehydrogenase.

    PubMed

    Engel, Paul C

    2011-09-01

    Detailed kinetic studies of bovine glutamate dehydrogenase [GDH] from the 1960s revealed complexities that remain to be fully explained. In the absence of heterotropic nucleotide regulators the enzyme follows a random pathway of substrate addition but saturation with ADP enforces a compulsory-order mechanism in which glutamate is the leading substrate. The rate dependence on NAD(P)(+) concentration is complex and is probably only partly explained by negative binding cooperativity. Bovine GDH eluded successful analysis by crystallographers for 30 years but the final structural solution presented in this symposium at last provides a comprehensible framework for much of the heterotropic regulation, focussing attention on an antenna region in the C-terminal tail, a structure that is missing in the slightly smaller hexameric GDHs of lower organisms. Nonetheless, our studies with one such smaller (clostridial) GDH reveal that even without the antenna the underlying core structure still mediates homotropic cooperativity, and the ability to generate a variety of mutants has made it possible to start to dissect this machinery. In addition, this short personal review discusses a number of unresolved issues such as the significance of phospholipid inhibition and of specific interaction with mRNA, and above all the question of why it is necessary to regulate an enzyme reputedly maintaining its reactants at equilibrium and whether this might be in some way related to its coexistence with an energy-linked transhydrogenase.

  1. Heart and Lung Metastases From Endometrial Stromal Sarcoma in a Forty-Two-Year-Old Woman

    PubMed Central

    Shakerian, Behnam; Mandegar, Mohammad Hossein; Moradi, Bahieh; Roshanali, Farideh

    2015-01-01

    Introduction: Low-grade endometrial stromal sarcoma (LG-ESS) is a malignant intrauterine tumor that rarely presents with distant metastasis. Simultaneous lung and cardiac metastases from LG-ESS is also an extremely rare event. Case Presentation: A 42-year-old woman presented with dyspnea and exercise intolerance. She had a history of hysterectomy and left salpingoophorectomy. She underwent second laparotomy as well as right oophorectomy after new finding of vaginal mass with histopathologic diagnosis of LG-ESS. Cardiac imaging techniques demonstrated tumoral process in the right atrium and ventricle, coronary sinus, and pulmonary outlet tract as well as multiple metastases in the lung fields. Successful complete surgical resection of the metastatic tumor in the right side of the heart and then radiotherapy were done. After 28 months, follow-up examination revealed no abnormality. Conclusions: We describe the first documented case of isolated intracardiac and lung metastases of a LG-ESS without concurrent abdominal or caval metastasis. PMID:26436070

  2. Homicide among Indigenous South Australians: a forty-year study (1969-2008).

    PubMed

    Temlett, Julia; Byard, Roger W

    2012-11-01

    A retrospective review of homicide cases among Aboriginal people in South Australia examined at Forensic Science SA was undertaken over a 40-year period from 1969 to 2008. A total of 90 Indigenous homicide victims were identified compared to 599 non-Indigenous victims over the same time period. Although homicide rates have fallen, the Indigenous homicide rate (ranging from 73.5 to 223.97 per 100,000) significantly exceeded the non-Indigenous rate (ranging from 8.16 to 12.6 per 100,000) for all decades (p<0.001). The most common methods of homicide in the Indigenous population involved blunt force and sharp force trauma, with gunshot, strangulation and other forms of homicides being encountered less often. While lack of access to firearms may explain the lower numbers of gunshot deaths it would not explain the low numbers of deaths due to strangulation. Considerable variability may, therefore, exist in the types of unnatural deaths that may be found in different cultural and ethnic groups, even within the same community.

  3. Neurostimulation in the treatment of primary headaches

    PubMed Central

    Miller, Sarah; Sinclair, Alex J; Davies, Brendan; Matharu, Manjit

    2016-01-01

    There is increasing interest in using neurostimulation to treat headache disorders. There are now several non-invasive and invasive stimulation devices available with some open-label series and small controlled trial studies that support their use. Non-invasive stimulation options include supraorbital stimulation (Cefaly), vagus nerve stimulation (gammaCore) and single-pulse transcranial magnetic stimulation (SpringTMS). Invasive procedures include occipital nerve stimulation, sphenopalatine ganglion stimulation and ventral tegmental area deep brain stimulation. These stimulation devices may find a place in the treatment pathway of headache disorders. Here, we explore the basic principles of neurostimulation for headache and overview the available methods of neurostimulation. PMID:27152027

  4. Forty years of improvements in European air quality: regional policy-industry interactions with global impacts

    NASA Astrophysics Data System (ADS)

    Crippa, Monica; Janssens-Maenhout, Greet; Dentener, Frank; Guizzardi, Diego; Sindelarova, Katerina; Muntean, Marilena; Van Dingenen, Rita; Granier, Claire

    2016-03-01

    The EDGARv4.3.1 (Emissions Database for Global Atmospheric Research) global anthropogenic emissions inventory of gaseous (SO2, NOx, CO, non-methane volatile organic compounds and NH3) and particulate (PM10, PM2.5, black and organic carbon) air pollutants for the period 1970-2010 is used to develop retrospective air pollution emissions scenarios to quantify the roles and contributions of changes in energy consumption and efficiency, technology progress and end-of-pipe emission reduction measures and their resulting impact on health and crop yields at European and global scale. The reference EDGARv4.3.1 emissions include observed and reported changes in activity data, fuel consumption and air pollution abatement technologies over the past 4 decades, combined with Tier 1 and region-specific Tier 2 emission factors. Two further retrospective scenarios assess the interplay of policy and industry. The highest emission STAG_TECH scenario assesses the impact of the technology and end-of-pipe reduction measures in the European Union, by considering historical fuel consumption, along with a stagnation of technology with constant emission factors since 1970, and assuming no further abatement measures and improvement imposed by European emission standards. The lowest emission STAG_ENERGY scenario evaluates the impact of increased fuel consumption by considering unchanged energy consumption since the year 1970, but assuming the technological development, end-of-pipe reductions, fuel mix and energy efficiency of 2010. Our scenario analysis focuses on the three most important and most regulated sectors (power generation, manufacturing industry and road transport), which are subject to multi-pollutant European Union Air Quality regulations. Stagnation of technology and air pollution reduction measures at 1970 levels would have led to 129 % (or factor 2.3) higher SO2, 71 % higher NOx and 69 % higher PM2.5 emissions in Europe (EU27), demonstrating the large role that technology has

  5. Dreams, Hopes, Realities: NASA's Goddard Space Flight Center, the First Forty Years

    NASA Technical Reports Server (NTRS)

    Wallace, Lane E.

    1999-01-01

    Throughout history, the great achievements of civilizations and cultures have been recorded in lists of dates and events. But to look only at the machinery, discoveries, or milestones is to miss the value of these achievements. Each goal achieved or discovery or made represents a supreme effort on the part of individual people who came and worked together for a purpose greater than themselves. Driven by an innate curiosity of the spirit, we have built civilizations and discovered new worlds, always reaching out beyond what we knew or thought was possible. These efforts may have used ships or machinery, but the achievement was that of the humans who made those machines possible- remarkable people willing to endure discomfort, frustration, fatigue, and the risk of failure in the hope of finding out something new. This is the case with the history of the Goddard Space Flight Center. This publication traces the legacy of successes, risks, disappointments and internationally recognized triumphs of the Center's first 40 years. It is a story of technological achievement and scientific discovery; of reaching back to the dawn of time and opening up a new set of eyes on our own planet Earth. In the end, it is not a story about machinery or discoveries, but a story about ourselves. If we were able to step off our planet, and if we continue to discover new mysteries and better technology, it is because the people who work at Goddard always had a passion for exploration and the dedication to make it happen. The text that follows is a testimony to the challenges people at the Goddard Space Flight Center have faced and overcome over almost half a century. Today, we stand on the threshold of a new and equally challenging era. It will once again test our ingenuity, skills, and flexibility as we find new ways of working with our colleagues in industry, government, and academia. Doing more with less is every bit as ambitious as designing the first science instrument to study the

  6. SEMPRE: Forty Years on

    ERIC Educational Resources Information Center

    Cox, Gordon; Crickmore, Leon; Plummeridge, Charles; Sergeant, Desmond

    2012-01-01

    This historical account traces the beginnings of the Society for Education, Music and Psychology Research (SEMPRE) to the founding of the Society for Research in Psychology of Music and Music Education (SRPMME) in 1972, which in turn had evolved from Arnold Bentley's Research in Music Education conferences instituted in 1966. The paper charts the…

  7. The injectable neurostimulator: an emerging therapeutic device.

    PubMed

    Li, Xiaolong; Serdijn, Wouter A; Zheng, Wei; Tian, Yubo; Zhang, Bing

    2015-07-01

    Injectable neurostimulators are currently applied in clinical trials to minimize the side effects such as discomfort, risk of infection, and post-surgery trauma, which can be pronounced with conventional, bulky implantable neurostimulators. Owing to its smaller size, wireless-updatable software, and wireless power supply, the injectable neurostimulator is presumably less invasive, 'smarter', and has a longer lifetime. We discuss the concept and development of the injectable neurostimulator, persistent implementation challenges, and obstacles to be overcome in its evolution. We survey the use of new materials, technologies, and design methods for injectable electrodes, batteries, antennas, and packaging to enhance reliability and other features. These advances in the field are accompanied by progress in electrophysiology, neuroscience, neurology, clinical trials, and treatments.

  8. The peripatetic cultural psychiatrist: reflections on a forty-five year longitudinal study of a South India village.

    PubMed

    Ullrich, Helen E

    2011-04-01

    This article presents one woman's odyssey, which began with a career in linguistics and later incorporated cultural psychiatry. While engaged in fieldwork as a linguist, studying the syntactic structure of Havyaka Kannada and dialectal accommodation among the castes in a South India village, I developed language skills and rapport with the village residents. Then I transferred my community-wide rapport to research on depression as a cultural psychiatrist. The articles I wrote on depression and its relationship to socialized passivity and endorsed assertiveness in progressive generations of South Indian women, illustrate the impact of change on mental health. The cultural background from my community-based longitudinal study of more than forty-five years has contributed to my understanding disorders in Indian patients living in a globalized world.

  9. David Blackwell’s Forty Years in the Idaho Desert, The Foundation for 21st Century Geothermal Research

    SciTech Connect

    McLing, Travis; McCurry, Mike; Cannon, Cody; Neupane, Ghanashyam; Wood, Thomas; Podgorney, Robert; Welhan, John; Mines, Greg; Mattson, Earl; Wood, Rachel; Palmer, Carl

    2015-04-01

    Dr. David Blackwell has had a profound influence on geo-thermal exploration and R&D in Idaho. Forty years have elapsed since the first Southern Methodist University (SMU) temperature logging truck rolled onto the high desert in Southern Idaho, yet even after so much time has elapsed, most recent and ongoing geothermal R&D can trace its roots to the foundational temperature studies led by Dr. Blackwell. We believe that the best way to honor any scientist is to see their work carried forward by others. As this paper demonstrates, it has been an easy task to find a host of Idaho researchers and students eager to contribute to this tribute paper. We organize this paper by ongoing or recent projects that continue to benefit left to Idaho by Dr. David Blackwell.

  10. Neurostimulation for Drug-Resistant Epilepsy

    PubMed Central

    DeGiorgio, Christopher M.; Krahl, Scott E.

    2013-01-01

    Purpose of Review: The purpose of this review is to provide an evidence-based update on the neurostimulation options available for patients with drug-resistant epilepsy in the United States and in European countries. Recent Findings: The field of neurostimulation for epilepsy has grown dramatically since 1997, when vagus nerve stimulation became the first device to be approved for epilepsy by the US Food and Drug Administration (FDA). New data from recently completed randomized controlled trials are available for deep brain stimulation of the anterior thalamus, responsive neurostimulation, and trigeminal nerve stimulation. Although vagus nerve stimulation is the only device currently approved in the United States, deep brain stimulation and responsive neurostimulation devices are awaiting FDA approval. Deep brain stimulation, trigeminal nerve stimulation, and transcutaneous vagus nerve stimulation are now approved for epilepsy in the European Union. In this article, the mechanisms of action, safety, and efficacy of new neurostimulation devices are reviewed, and the key advantages and disadvantages of each are discussed. Summary: The exponential growth of the field of neuromodulation for epilepsy is an exciting development; these new devices provide physicians with new options for patients with drug-resistant epilepsy. PMID:23739108

  11. Closed-loop neurostimulation: the clinical experience.

    PubMed

    Sun, Felice T; Morrell, Martha J

    2014-07-01

    Neurostimulation is now an established therapy for the treatment of movement disorders, pain, and epilepsy. While most neurostimulation systems available today provide stimulation in an open-loop manner (i.e., therapy is delivered according to preprogrammed settings and is unaffected by changes in the patient's clinical symptoms or in the underlying disease), closed-loop neurostimulation systems, which modulate or adapt therapy in response to physiological changes, may provide more effective and efficient therapy. At present, few such systems exist owing to the complexities of designing and implementing implantable closed-loop systems. This review focuses on the clinical experience of four implantable closed-loop neurostimulation systems: positional-adaptive spinal cord stimulation for treatment of pain, responsive cortical stimulation for treatment of epilepsy, closed-loop vagus nerve stimulation for treatment of epilepsy, and concurrent sensing and stimulation for treatment of Parkinson disease. The history that led to the development of the closed-loop systems, the sensing, detection, and stimulation technology that closes the loop, and the clinical experiences are presented.

  12. Building on and Honoring Forty Years of PBL Scholarship from Howard Barrows: A Scientometric, Large-Scale Data, and Visualization-Based Analysis

    ERIC Educational Resources Information Center

    Xian, Hanjun; Madhavan, Krishna

    2013-01-01

    Over the past forty years, Howard Barrows' contributions to PBL research have influenced and guided educational research and practice in a diversity of domains. It is necessary to make visible to all PBL scholars what has been accomplished, what is perceived as significant, and what is the scope of applicability for Barrows' groundbreaking…

  13. Two-year seizure reduction in adults with medically intractable partial onset epilepsy treated with responsive neurostimulation: Final results of the RNS System Pivotal trial

    PubMed Central

    Heck, Christianne N; King-Stephens, David; Massey, Andrew D; Nair, Dileep R; Jobst, Barbara C; Barkley, Gregory L; Salanova, Vicenta; Cole, Andrew J; Smith, Michael C; Gwinn, Ryder P; Skidmore, Christopher; Van Ness, Paul C; Bergey, Gregory K; Park, Yong D; Miller, Ian; Geller, Eric; Rutecki, Paul A; Zimmerman, Richard; Spencer, David C; Goldman, Alica; Edwards, Jonathan C; Leiphart, James W; Wharen, Robert E; Fessler, James; Fountain, Nathan B; Worrell, Gregory A; Gross, Robert E; Eisenschenk, Stephan; Duckrow, Robert B; Hirsch, Lawrence J; Bazil, Carl; O'Donovan, Cormac A; Sun, Felice T; Courtney, Tracy A; Seale, Cairn G; Morrell, Martha J

    2014-01-01

    Objective To demonstrate the safety and effectiveness of responsive stimulation at the seizure focus as an adjunctive therapy to reduce the frequency of seizures in adults with medically intractable partial onset seizures arising from one or two seizure foci. Methods Randomized multicenter double-blinded controlled trial of responsive focal cortical stimulation (RNS System). Subjects with medically intractable partial onset seizures from one or two foci were implanted, and 1 month postimplant were randomized 1:1 to active or sham stimulation. After the fifth postimplant month, all subjects received responsive stimulation in an open label period (OLP) to complete 2 years of postimplant follow-up. Results All 191 subjects were randomized. The percent change in seizures at the end of the blinded period was −37.9% in the active and −17.3% in the sham stimulation group (p = 0.012, Generalized Estimating Equations). The median percent reduction in seizures in the OLP was 44% at 1 year and 53% at 2 years, which represents a progressive and significant improvement with time (p < 0.0001). The serious adverse event rate was not different between subjects receiving active and sham stimulation. Adverse events were consistent with the known risks of an implanted medical device, seizures, and of other epilepsy treatments. There were no adverse effects on neuropsychological function or mood. Significance Responsive stimulation to the seizure focus reduced the frequency of partial-onset seizures acutely, showed improving seizure reduction over time, was well tolerated, and was acceptably safe. The RNS System provides an additional treatment option for patients with medically intractable partial-onset seizures. PMID:24621228

  14. Genetic progress resulting from forty-three years of breeding of the carioca common bean in Brazil.

    PubMed

    Barili, L D; Vale, N M; Moura, L M; Paula, R G; Silva, F F; Carneiro, J E S

    2016-08-05

    We aimed to evaluate 40 common bean cultivars recommended by various Brazilian research institutions between 1970 and 2013 and estimate the genetic progress obtained for grain yield and other agronomic traits. Additionally, we proposed a bi-segmented nonlinear regression model to infer the year in which breeding began to show significant gains in Brazil. The experiment was carried out in Viçosa/MG and Coimbra/MG, in the dry and winter seasons of 2013. For this, a randomized complete block design with three replications was employed. The following traits were evaluated: number of pods per plant (NPP); number of seeds per pod (NSP); 1000-seed weight (W1000); grain yield (Yield); plant architecture (Arch); and grain aspect (GA). Genotypic means were estimated over years using linear mixed models, and genetic gains were estimated using bi-segmented nonlinear regression models. In summary, the methodology proposed in the present study indicated that bean breeding programs in Brazil began to influence Yield beginning in 1990, resulting in a gain of 6.74% per year (68.15 kg/ha per year). The years from which estimated genetic progress for NPP (5.62% per year), NSP (4.59% per year), W1000 (2.08% per year), and GA (1.36% per year) began to increase were 1994, 1990, 1989, and 1986, respectively.

  15. Forty-Year Follow-up of Full-Thickness Skin Graft After Thermal Burn Injury to the Volar Hand

    PubMed Central

    Kasdan, Morton L.; Wilhelmi, Bradon J.

    2016-01-01

    Background: The hands are commonly affected in severe thermal burn injuries. Resulting contractures lead to significant loss of function. Burn contracture release and skin grafting are necessary to restore hand function. We report a case in which surgical reconstruction of a volar hand burn was performed with full-thickness skin grafting. The patient had a 40-year follow-up to assess the function and cosmesis of the repaired hand. Methods: We report a case in which a 15-month-old boy presented after receiving third-degree burns to the left volar hand, including the flexural aspects of the index, long, and ring fingers by placing it on a hot kitchen stove burner. The patient subsequently underwent scar contracture release and full-thickness skin grafting. Results: Eleven years after reconstruction, further contractures developed associated with the patient's growth, which were reconstructed with repeat full-thickness skin graft from the inguinal region. No recurrence was witnessed afterward and 40 years after initial injury, the patient maintains full activities of daily living and use of his hand in his occupation. Conclusions: There is debate regarding the superiority of split-thickness versus full-thickness grafts during reconstruction. Our case strengthens the argument for durability of a full-thickness skin graft following thermal burn injury. PMID:27555888

  16. A case of mimicking angioedema: chin silicone granulomatous reaction spreading all over the face after receiving liquid silicone injection forty years previously.

    PubMed

    Chen, Yu-Cheng; Chen, Mei-Ling; Chiu, Ying-Ming

    2011-06-01

    Liquid injectable silicone has been used for soft tissue augmentation for five decades. Many complications following liquid silicone injection have been reported. To diagnose and manage silicone granuloma remains difficult. Silicone granuloma must be diagnosed with the history of liquid silicone injection and the histology of tissue biopsy. We presented a case of granulomatous reaction after the injection of liquid silicone for chin augmentation forty years ago, causing total facial swelling, which mimicking angioedema initially. We administered methylprednisolone to the patient. Initial response to methylprednisolone was favorable.

  17. Are risk factors common to thyroid cancer and nodule? A forty years observational time-trend study.

    PubMed

    Carpi, Angelo; Rossi, Giuseppe; Romani, Rossana; Di Coscio, Giancarlo; Nicolini, Andrea; Simoncini, Tommaso; Russo, Matteo; Mechanick, Jeffrey

    2012-01-01

    A progressive increase in the incidence of thyroid cancer (TC) has been reported over the last few decades. This either reflects the increased number of newly discovered and accurately selected thyroid nodules with more sensitive technologies and a relative more potent carcinogenic effect of pathogenetic factors in malignant, but not benign nodules. This observational time-trend study addresses this issue by analysing the proportion of TC within 8411 consecutive thyroid nodule (TN) patients evaluated in Pisa by the same pathology Department and individual clinician over a four-decade period. From 1972 to 1979 surgery was used to detect TC among the TN patients: 1140 TN patients were operated on and 35 cancers were detected (3.1% of all the TN patients). Subsequently, needle aspiration techniques were used to select TN for surgery. From 1980 to 1992, 5403 TN patients were examined, 483 were selected for surgery, and 150 cancers were found (2.8% of all the TN patients). From 1993 to 2010, 1568 TN patients were examined, 143 were selected for surgery, and 46 cancers were found (2.9% of all the TN patients). Therefore, in the University Hospital of Pisa, and independent of preoperative TN selection protocols, these proportions of TN eventually found to harbor TC remained statistically unchanged over 40 years (p = 0.810). This finding suggests that pathogenic risk factors and more sensitive diagnostic technologies did not differentially affect the incidence of TN and TC.

  18. The special programme of research in human reproduction: forty years of activities to achieve reproductive health for all.

    PubMed

    Benagiano, Giuseppe; d'Arcangues, Catherine; Harris Requejo, Jennifer; Schafer, Alessandra; Say, Lale; Merialdi, Mario

    2012-01-01

    The Special Programme of Research in Human Reproduction (HRP), co-sponsored by the UNDP, UNFPA, WHO, and the World Bank, is celebrating 40 years of activities with an expansion of its mandate and new co-sponsors. When it began, in 1972, the main focus was on evaluating the acceptability, effectiveness, and safety of existing fertility-regulating methods, as well as developing new, improved modalities for family planning. In 1994, HRP not only made major contributions to the Plan of Action of the International Conference on Population and Development (ICPD); it also broadened its scope of work to include other aspects of health dealing with sexuality and reproduction, adding a specific perspective on gender issues and human rights. In 2002, HRP's mandate was once again broadened to include sexually transmitted infections and HIV/AIDS and in 2003 it was further expanded to research activities on preventing violence against women and its many dire health consequences. Today, the work of the Programme includes research on: the sexual and reproductive health of adolescents, women, and men; maternal and perinatal health; reproductive tract and sexually transmitted infections (including HIV/AIDS); family planning; infertility; unsafe abortion; sexual health; screening for cancer of the cervix in developing countries, and gender and reproductive rights. Additional activities by the Programme have included: fostering international cooperation in the field of human reproduction; the elaboration of WHO's first Global Reproductive Health Strategy; work leading to the inclusion of ICPD's goal 'reproductive health for all by 2015' into the Millennium Development Goal framework; the promotion of critical interagency statements on the public health, legal, and human rights implications of female genital mutilation and gender-biased sex selection. Finally, HRP has been involved in the creation of guidelines and tools, such as the 'Medical eligibility criteria for contraceptive use

  19. Six-Degree Head-Down Tilt Bed Rest: Forty Years of Development as a Physiological Analog for Weightlessness

    NASA Technical Reports Server (NTRS)

    Smith, Jeffrey D.; Cromwell, Ronita L.; Kundrot, Craig E.; Charles, John B.

    2011-01-01

    -degrees HDT model must continue to be scrutinized, re-examined, validated and compared to other analog environments whenever possible. Only by understanding the strengths and limits of this model, will it continue to serve as a critical physiological analog to spaceflight for many more years to come.

  20. neuroBi: A Highly Configurable Neurostimulator for a Retinal Prosthesis and Other Applications.

    PubMed

    Slater, Kyle D; Sinclair, Nicholas C; Nelson, Timothy S; Blamey, Peter J; McDermott, Hugh J

    2015-01-01

    To evaluate the efficacy of a suprachoroidal retinal prosthesis, a highly configurable external neurostimulator is required. In order to meet functional and safety specifications, it was necessary to develop a custom device. A system is presented which can deliver charge-balanced, constant-current biphasic pulses, with widely adjustable parameters, to arbitrary configurations of output electrodes. This system is shown to be effective in eliciting visual percepts in a patient with approximately 20 years of light perception vision only due to retinitis pigmentosa, using an electrode array implanted in the suprachoroidal space of the eye. The flexibility of the system also makes it suitable for use in a number of other emerging clinical neurostimulation applications, including epileptic seizure suppression and closed-loop deep brain stimulation. Clinical trial registration number NCT01603576 (www.clinicaltrials.gov).

  1. neuroBi: A Highly Configurable Neurostimulator for a Retinal Prosthesis and Other Applications

    PubMed Central

    Slater, Kyle D.; Nelson, Timothy S.; Blamey, Peter J.; Mcdermott, Hugh J.

    2015-01-01

    To evaluate the efficacy of a suprachoroidal retinal prosthesis, a highly configurable external neurostimulator is required. In order to meet functional and safety specifications, it was necessary to develop a custom device. A system is presented which can deliver charge-balanced, constant-current biphasic pulses, with widely adjustable parameters, to arbitrary configurations of output electrodes. This system is shown to be effective in eliciting visual percepts in a patient with approximately 20 years of light perception vision only due to retinitis pigmentosa, using an electrode array implanted in the suprachoroidal space of the eye. The flexibility of the system also makes it suitable for use in a number of other emerging clinical neurostimulation applications, including epileptic seizure suppression and closed-loop deep brain stimulation. Clinical trial registration number NCT01603576 (www.clinicaltrials.gov). PMID:27170910

  2. Forty Four Years a King.

    ERIC Educational Resources Information Center

    Minneapolis Public Schools, Minn. Dept. of Intergroup Education.

    This curriculum unit contains guidelines for Martin Luther King Jr. Day, January 15th. Items included in the guide are: a list of suggested activities, a short biography of Dr. King, excerpts from some of his speeches including the famous, "I Have A Dream" speech, a play, study questions, "A King's Journey", a game, and a story…

  3. Family Development's First Forty Years.

    ERIC Educational Resources Information Center

    Duvall, Evelyn Millis

    1988-01-01

    Reviews the history of human development, and of family development and its interdisciplinary nature. Explores variations as well as the universality of the family life cycle and developmental tasks. Presents examples of the applications of family developmental concepts by a variety of practitioners in the family field, offering ideas on research…

  4. Forty Years on: Touchstones Now

    ERIC Educational Resources Information Center

    Benton, Michael; Benton, Peter

    2008-01-01

    The "Touchstones" series of poetry anthologies was first published in the UK between 1968 and 1972 in five volumes. Over a million copies and three revisions later, "Touchstones Now 11-14" appeared in the summer of 2008. Few, if any, books for the classroom can claim such longevity. In this article, the compilers of the…

  5. [Clinical experience of usage of neurostimulator in regionar anesthesia].

    PubMed

    Rudenko, M I; Kolobaeva, E G

    2006-09-01

    The elaboration of more reliable and simple methods of transmitted and plexus anestesias has provided a wide clinical usage of regionar anestesia (RA) during the operations on extremities. The creation of devices to identificate (locate) nerval bearer and plexes was also an important factor for increasing quantity of RA. For such identification we use the portable "Innervator 232" neurostimulator manufactured by "Fisher & Paykel Ltd.", New Zealand. Successful conduction of transmitted and plexus anesthesia depends a lot on anesthesiologist's knowledge of anatomy-topography location of nerval bearer and plexes, precise fulfillment of anesthesia, manual capabilities of physician and obtaining a paresthesia or muscular contraction during the identification of nerval bearer with the help of neurostimulator. RA is secure, effective, and provides less risk for a patient. With neurostimulation the amount of successful anesthesias increases up to 98%. The neurostimulator is easy to use, clinically effective in emergency and planned surgeries for identification of nerval bearer and plexes.

  6. Neurostimulation for neck pain and headache.

    PubMed

    Hong, Jennifer; Ball, Perry A; Fanciullo, Gilbert J

    2014-03-01

    Patients with medically refractory headache disorders are a rare and challenging-to-treat group. The introduction of peripheral neurostimulation (PNS) has offered a new avenue of treatment for patients who are appropriate surgical candidates. The utility of PNS for headache management is actively debated. Preliminary reports suggested that 60-80% of patients with chronic headache who have failed maximum medical therapy respond to PNS. However, complications rates for PNS are high. Recent publication of 2 large randomized clinical trials with conflicting results has underscored the need for further research and careful patient counseling. In this review, we summarize the current evidence for PNS in treatment of chronic migraine, trigeminal autonomic cephalagias and occipital neuralgia, and other secondary headache disorders.

  7. Electromagnetic compatibility of implantable neurostimulators to RFID emitters

    PubMed Central

    2011-01-01

    Background The objective of this study is to investigate electromagnetic compatibility (EMC) of implantable neurostimulators with the emissions from radio frequency identification (RFID) emitters. Methods Six active implantable neurostimulators with lead systems were tested for susceptibility to electromagnetic fields generated by 22 RFID emitters. These medical devices have been approved for marketing in the U.S. for a number of intended uses that include: epilepsy, depression, incontinence, Parkinsonian tremor and pain relief. Each RFID emitter had one of the following carrier frequencies: 125 kHz, 134 kHz, 13.56 MHz, 433 MHz, 915 MHz and 2.45 GHz Results The test results showed the output of one of the implantable neurostimulators was inhibited by 134 kHz RFID emitter at separation distances of 10 cm or less. The output of the same implantable neurostimulator was also inhibited by another 134 kHz RFID emitter at separation distances of 10 cm or less and also showed inconsistent pulsing rate at a separation distance of 15 cm. Both effects occurred during and lasted through out the duration of the exposure. Conclusions The clinical significance of the effects was assessed by a clinician at the U.S. Food and Drug Administration. The effects were determined to be clinically significant only if they occurred for extended period of time. There were no observed effects from the other 5 implantable neurostimulators or during exposures from other RFID emitters. PMID:21658266

  8. Getting the Lead Out of Bermuda; The Legacy of a Forty Year Record in the North Atlantic Using a Transient Experiment in the Atmosphere and Water

    NASA Astrophysics Data System (ADS)

    Church, T. M.; Alleman, L. Y.; Veron, A. J. J.; Boyle, E. A.; Zurbrick, C.; Patterson, C. C.; Flegal, A. R., Jr.

    2015-12-01

    Some forty years ago, Schaule and Patterson established the first accurate profile of lead in waters off Bermuda. In evidence was a massive environmental insult from lead emissions being carried seaward by the atmosphere over the Sargasso Sea. Further documentation was possible using contiguous time series in the atmosphere on Bermuda, surface sea water nearby and recorded in local corals. Lead had then an overwhelming source from the combustion of gasoline, primarily in the USA and secondarily in Europe. These were carried to Bermuda on seasonally alternating temperate and trade winds from the west and east, respectively. The anthropogenic sources were well distinguished based on the unique radiogenic nature of stable lead isotopes in the gasoline being used by these countries. Subsequently, decreasing use in the west (USA) followed by that in the east (Europe) was isotopically evident. As such, the two signatures were subjected to transient mixing in the atmosphere and subsequently with depth in ocean. A transient experiment uses data during 1996-1998, a period of transition in leaded gasoline use in the USA and Europe. Here are complimentary records of lead concentration and stable isotopes in atmospheric deposition and surface waters. The results allow an isotopic mass balance, indicating much of the lead in Bermuda surface water at that time may not have been deposited locally. As such, it may be presumed to reflect easterly advection of some lead at the surface under limited scavenging via the prevailing subtropical gyre circulation. These annual circulation periods are consistent with both physical data and another lead isotopic mass balance in the east. Going forward, Bermuda time series of trace elements and isotopes such as lead could continue to record climatological (e.g. NAO) transients in atmospheric scavenging, potential impact on surface ecosystems, and changes in mixing into deeper waters of the Sargasso Sea and points further afield.

  9. Electromagnetic Compatibility Testing of Implantable Neurostimulators Exposed to Metal Detectors

    PubMed Central

    Seidman, Seth J; Kainz, Wolfgang; Casamento, Jon; Witters, Donald

    2010-01-01

    This paper presents results of electromagnetic compatibility (EMC) testing of three implantable neurostimulators exposed to the magnetic fields emitted from several walk-through and hand-held metal detectors. The motivation behind this testing comes from numerous adverse event reports involving active implantable medical devices (AIMDs) and security systems that have been received by the Food and Drug Administration (FDA). EMC testing was performed using three neurostimulators exposed to the emissions from 12 walk-through metal detectors (WTMDs) and 32 hand-held metal detectors (HHMDs). Emission measurements were performed on all HHMDs and WTMDs and summary data is presented. Results from the EMC testing indicate possible electromagnetic interference (EMI) between one of the neurostimulators and one WTMD and indicate that EMI between the three neurostimulators and HHMDs is unlikely. The results suggest that worst case situations for EMC testing are hard to predict and testing all major medical device modes and setting parameters are necessary to understand and characterize the EMC of AIMDs. PMID:20448818

  10. Neurostimulation for fecal incontinence after correction of repair of imperforate anus

    PubMed Central

    Bougie, Alexandre; McFadden, Nathalie; Mayer, Sandeep; Lebel, Michel; Devroede, Ghislain

    2017-01-01

    We are reporting the case of a 32-year-old female who had suffered from fecal incontinence (FI). She was born with an imperforate anus and a recto-vaginal fistula; she underwent repair at 6 mo of age. At 29 years of age, she was still fecally incontinent despite extensive pelvic floor reeducation. A magnetic resonance imaging and an anal electromyography were performed. Because her symptoms were considered to be probably due to extra-sphincteric implantation of the neo-anus, a redo was performed of the recto-neo-anal intra-sphincteric anastomosis. A neurostimulator device was subsequently implanted for persistent incontinence. Solid and liquid FI resolved, and her quality of life improved markedly. Combining surgery to correct the position of the neo-anus within the anal sphincter complex and neurostimulation could thus become a new approach in cases of refractory FI for patients with imperforate anus as a newborn. Follow-up into adulthood after pediatric imperforate anus surgery should be recommended for adult patients with persistent FI. PMID:28352637

  11. Short pulse width widens the therapeutic window of subthalamic neurostimulation

    PubMed Central

    Reich, Martin M; Steigerwald, Frank; Sawalhe, Anna D; Reese, Rene; Gunalan, Kabilar; Johannes, Silvia; Nickl, Robert; Matthies, Cordula; McIntyre, Cameron C; Volkmann, Jens

    2015-01-01

    We explored the impact of pulse durations <60 μsec on the therapeutic window of subthalamic neurostimulation in Parkinson's disease. Current thresholds for full rigidity control and first muscle contractions were evaluated at pulse durations between 20 and 120 μsec during a monopolar review session in four patients. The average therapeutic window was 2.16 mA at 60 μsec, which proportionally increased by 182% at 30 μsec, while decreasing by 46% at 120 μsec. Measured chronaxies and model data suggest, that pulse durations <60 μsec lead to a focusing of the neurostimulation effect on smaller diameter axons close to the electrode while avoiding stimulation of distant pyramidal tract fibers. PMID:25909087

  12. Technical aspects of neurostimulation: Focus on equipment, electric field modeling, and stimulation protocols.

    PubMed

    Klooster, D C W; de Louw, A J A; Aldenkamp, A P; Besseling, R M H; Mestrom, R M C; Carrette, S; Zinger, S; Bergmans, J W M; Mess, W H; Vonck, K; Carrette, E; Breuer, L E M; Bernas, A; Tijhuis, A G; Boon, P

    2016-06-01

    Neuromodulation is a field of science, medicine, and bioengineering that encompasses implantable and non-implantable technologies for the purpose of improving quality of life and functioning of humans. Brain neuromodulation involves different neurostimulation techniques: transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), vagus nerve stimulation (VNS), and deep brain stimulation (DBS), which are being used both to study their effects on cognitive brain functions and to treat neuropsychiatric disorders. The mechanisms of action of neurostimulation remain incompletely understood. Insight into the technical basis of neurostimulation might be a first step towards a more profound understanding of these mechanisms, which might lead to improved clinical outcome and therapeutic potential. This review provides an overview of the technical basis of neurostimulation focusing on the equipment, the present understanding of induced electric fields, and the stimulation protocols. The review is written from a technical perspective aimed at supporting the use of neurostimulation in clinical practice.

  13. Forty Years of "Pastoral Care": An Appraisal of Michael Marland's Seminal Book and Its Significance for Pastoral Care in Schools

    ERIC Educational Resources Information Center

    Best, Ron

    2014-01-01

    Michael Marland's seminal book: "Pastoral Care" was published 40 years ago this year. The thesis of the book--that pastoral care is the central task of the school, and must be planned and institutionalized through pastoral roles and structures--is explored against the background of the social, cultural and educational developments…

  14. Forty Years of Civics in the J. E. R.: Changes in Civics Teaching since World War II as Seen in the Journal of Educational Research.

    ERIC Educational Resources Information Center

    Kay, Linda

    1980-01-01

    The "Journal of Educational Research" has reflected educational and social changes for 80 years. A survey of articles since 1945 reveals the effect of sociocultural developments, new inventions (television), world affairs, and educational innovations such as team teaching on education in general and social studies teaching in particular.…

  15. Forty years of shunt surgery at Rigshospitalet, Denmark: a retrospective study comparing past and present rates and causes of revision and infection

    PubMed Central

    Kofoed Månsson, Philip; Johansson, Sofia; Ziebell, Morten; Juhler, Marianne

    2017-01-01

    Objective The objective of this study is to review our experience of shunt surgery by investigating 40 years of development in terms of rates of revision and infection, shunt survival and risk factors. Design and participants Medical records and operative reports were reviewed retrospectively for all patients who underwent primary shunt surgery at our department in the years 2010 to 2012. All results were compared with a previous study from our department. A mixed population consisting of 434 patients was included. Adults (≥15 years) accounted for 89.9% of all patients and the mean follow-up time was 1.71 years. Results Overall, 42.6% had a revision of which 65.4% fell within 6 months postoperatively. Low age, high-risk diagnoses and less severe brain injury were associated with a higher risk of revision. One and 5-year shunt survival probabilities were 66.2% (61.5–70.9) and 48.0% (41.1–54.9). Within 4 weeks postoperatively, 3.2% had an infection and overall infection rate was 5.5%. Short duration of surgery and the use of antibiotic prophylaxis were associated with a lower risk of infection. The most frequent causes of revision were valve defects (18.4%) and proximal defects or obstructions (15.7%). Compared to the previous study, no convincing improvement was found with regard to the revision rate (42.6% vs 48.3%, p 0.060) or overall infection rate (5.5% vs 7.4%, p 0.261). Conclusions Regardless of changes in patient demographics, techniques and equipment, risk of revision and infection still constitutes a major challenge in shunt surgery. The absence of convincing improvements calls for more studies concerning strategies to reduce complications. PMID:28093434

  16. Forty-seven years of weekly atmospheric black carbon measurements in the Finnish Arctic: Decrease in black carbon with declining emissions

    NASA Astrophysics Data System (ADS)

    Dutkiewicz, Vincent A.; DeJulio, Anthony M.; Ahmed, Tanveer; Laing, James; Hopke, Philip K.; Skeie, Ragnhild B.; Viisanen, Yrjö; Paatero, Jussi; Husain, Liaquat

    2014-06-01

    Concentrations of atmospheric black carbon, [BC], were determined from filter samples collected weekly at Kevo, Finland (69°45'N, 27°02'E), from 1964 to 2010 using optical and thermal optical methods. The data provide the longest record of directly measured [BC] in the Arctic. The mean winter, spring, summer, and autumn [BC] based on the entire data set were 339, 199, 127, and 213 ng m-3, respectively. Annual mean [BC] decreased from ~300 in ~1970 to 82 ng m-3 in 2010. [BC] data sets from other Arctic sites show similar trends, but concentrations at Kevo are generally higher. From ~1970 to 2010 the [BC] decreased by ~1.8% yr-1. However, [BC] did not decrease monotonically. Instead, cyclical peaks occurred around 1976-1977, 1985-1987, and 1999. During such periods, nickel concentrations were well correlated with [BC]. This suggests that emissions from extensive ore smelting on the Kola Peninsula were significant contributors of particulate matter observed at Kevo. Simulations of [BC] at Kevo using the OsloCTM3 model using different emission inventories and meteorological data sets were performed. Modeled concentrations were lower than observed by a factor of 4. The results indicated that circulation changes can explain year to year variability, but the downward trend in the observations is mostly explained by emissions. Emission inventories in Europe, Russia, and the former Soviet Union are poorly constrained and appear to need revision in order to match observed trends in BC atmospheric concentrations.

  17. Forty Years On1: Teachers’ Assessments of Children’s Personality Traits Predict Self-Reported Health Behaviors and Outcomes at Midlife

    PubMed Central

    Hampson, Sarah E.; Goldberg, Lewis R.; Vogt, Thomas M.; Dubanoski, Joan P.

    2005-01-01

    A life-span health-behavior model was investigated in this longitudinal study of personality influences on health. Teachers assessed 963 elementary school children on traits that formed scales assessing the dimensions of the five-factor (Big Five) model of personality. Smoking, alcohol use, body mass index (BMI), and self-rated health were assessed 40 years later in midlife. Childhood personality traits were significantly associated with all four outcomes, and the effects were consistently larger for women than men. For men and women, childhood Conscientiousness was associated with less adult smoking and better adult self-rated health and, for women only, with lower adult BMI. Mediation analyses suggested that the effects of Conscientiousness on self-rated health were partially mediated by smoking and BMI. These findings add to the growing evidence that childhood personality traits predict adult health outcomes, and are discussed in terms of future testing of the life-span health-behavior model. PMID:16448298

  18. Forty years of carabid beetle research in Europe – from taxonomy, biology, ecology and population studies to bioindication, habitat assessment and conservation

    PubMed Central

    Kotze, D. Johan; Brandmayr, Pietro; Casale, Achille; Dauffy-Richard, Emmanuelle; Dekoninck, Wouter; Koivula, Matti J.; Lövei, Gábor L.; Mossakowski, Dietrich; Noordijk, Jinze; Paarmann, Wilfried; Pizzolotto, Roberto; Saska, Pavel; Schwerk, Axel; Serrano, José; Szyszko, Jan; Taboada, Angela; Turin, Hans; Venn, Stephen; Vermeulen, Rikjan; Zetto, Tullia

    2011-01-01

    Abstract ‘Carabidologists do it all’ (Niemelä 1996a) is a phrase with which most European carabidologists are familiar. Indeed, during the last half a century, professional and amateur entomologists have contributed enormously to our understanding of the basic biology of carabid beetles. The success of the field is in no small part due to regular European Carabidologists’ Meetings, which started in 1969 in Wijster, the Netherlands, with the 14th meeting again held in the Netherlands in 2009, celebrating the 40th anniversary of the first meeting and 50 years of long-term research in the Dwingelderveld. This paper offers a subjective summary of some of the major developments in carabidology since the 1960s. Taxonomy of the family Carabidae is now reasonably established, and the application of modern taxonomic tools has brought up several surprises like elsewhere in the animal kingdom. Progress has been made on the ultimate and proximate factors of seasonality and timing of reproduction, which only exceptionally show non-seasonality. Triggers can be linked to evolutionary events and plausibly explained by the “taxon cycle” theory. Fairly little is still known about certain feeding preferences, including granivory and ants, as well as unique life history strategies, such as ectoparasitism and predation on higher taxa. The study of carabids has been instrumental in developing metapopulation theory (even if it was termed differently). Dispersal is one of the areas intensively studied, and results show an intricate interaction between walking and flying as the major mechanisms. The ecological study of carabids is still hampered by some unresolved questions about sampling and data evaluation. It is recognised that knowledge is uneven, especially concerning larvae and species in tropical areas. By their abundance and wide distribution, carabid beetles can be useful in population studies, bioindication, conservation biology and landscape ecology. Indeed, 40 years

  19. Forty years of carabid beetle research in Europe - from taxonomy, biology, ecology and population studies to bioindication, habitat assessment and conservation.

    PubMed

    Kotze, D Johan; Brandmayr, Pietro; Casale, Achille; Dauffy-Richard, Emmanuelle; Dekoninck, Wouter; Koivula, Matti J; Lövei, Gábor L; Mossakowski, Dietrich; Noordijk, Jinze; Paarmann, Wilfried; Pizzolotto, Roberto; Saska, Pavel; Schwerk, Axel; Serrano, José; Szyszko, Jan; Taboada, Angela; Turin, Hans; Venn, Stephen; Vermeulen, Rikjan; Zetto, Tullia

    2011-01-01

    'Carabidologists do it all' (Niemelä 1996a) is a phrase with which most European carabidologists are familiar. Indeed, during the last half a century, professional and amateur entomologists have contributed enormously to our understanding of the basic biology of carabid beetles. The success of the field is in no small part due to regular European Carabidologists' Meetings, which started in 1969 in Wijster, the Netherlands, with the 14th meeting again held in the Netherlands in 2009, celebrating the 40th anniversary of the first meeting and 50 years of long-term research in the Dwingelderveld. This paper offers a subjective summary of some of the major developments in carabidology since the 1960s. Taxonomy of the family Carabidae is now reasonably established, and the application of modern taxonomic tools has brought up several surprises like elsewhere in the animal kingdom. Progress has been made on the ultimate and proximate factors of seasonality and timing of reproduction, which only exceptionally show non-seasonality. Triggers can be linked to evolutionary events and plausibly explained by the "taxon cycle" theory. Fairly little is still known about certain feeding preferences, including granivory and ants, as well as unique life history strategies, such as ectoparasitism and predation on higher taxa. The study of carabids has been instrumental in developing metapopulation theory (even if it was termed differently). Dispersal is one of the areas intensively studied, and results show an intricate interaction between walking and flying as the major mechanisms. The ecological study of carabids is still hampered by some unresolved questions about sampling and data evaluation. It is recognised that knowledge is uneven, especially concerning larvae and species in tropical areas. By their abundance and wide distribution, carabid beetles can be useful in population studies, bioindication, conservation biology and landscape ecology. Indeed, 40 years of carabidological

  20. [Case with Emery-Dreifuss muscular dystrophy diagnosed forty-two years after onset and implanted with a cardiac resynchronization therapy defibrillator].

    PubMed

    Sakiyama, Yoshio; Watanabe, Eri; Otsuka, Mieko; Hirahara, Taishi; Momomura, Shinichi; Hayashi, Yukiko

    2014-01-01

    The patient was a 53-year-old male. He showed steppage gait at the age of 11 and equinus foot at 13. He walked unaided with shoe-insoles to support his heels. Atrial fibrillation and cardiac hypertrophy were found in his 30s, and ventricular tachycardia (VT) was observed at the age of 48. Electrophysiological studies were performed, but VT was not sustained, symptomatic, or showed signs of infra-Hisian block, and a pacemaker was not indicated. At 53, he was introduced to a neurologist because of tetraplegia after the first episode of syncope. A spinal MR showed ossification of posterior longitudinal ligament (OPLL) and central cervical cord injury. Furthermore, he presented not only contracture in his shoulder, elbow, and ankles but also atrophy in his scapulohumeral and gastrocnemius muscles. In accordance with a diagnosis of Emery-Dreifuss muscular dystrophy (EDMD), provocative testing of VT was carried out, and a cardiac resynchronization therapy defibrillator (CRT-D) was implanted. Later, a mutation analysis of the LMNA gene disclosed a known missense mutation of p.Arg377His, and we diagnosed him as EDMD2 (laminopathy). Contractures could be the clue to diagnose EDMD and indicate the need for pacemakers and defibrillators in patients with cardiac conduction disorders.

  1. Development of genetics in the world and in Croatia--forty years of the Croatian Society of Human Genetics of the Croatian Medical Association.

    PubMed

    Zergollern-Ĉupak, Ljiljana; Barišić, Ingeborg; Moronin Pohovski, Leona

    2014-09-01

    Resulting from several basic scientific disciplines, genetics has made impressive progress in the last century by discoveries of the heredity rules and genome structure, and by identification of the genes that determine the occurrence and characteristics of human diseases. In Croatia, the development of genetics began in the middle of the past century by the pioneering work of clinicians and basic scientists, which resulted in significant development of this scientific discipline that has quickly found its practical application in clinical genetics-cytogenetics, molecular genetics and prenatal diagnosis. The rapid advancement of technology and knowledge of genetics in recent decades has led to the development of genomics and related disciplines, entering the revolutionary new era of personalized medicine. Currently, much more data can be collected than interpreted. The data of electronic medical records, genomics, epigenetics, proteomics, meta- bolomics and microbiomics should be integrated and interpreted at the level of individual genome. Extensive use of new information will open a range of ethical issues that we must face timely. It is expected that in the forthcoming years, we will be able to learn more about genetics than what we have learned throughout the history of medicine. We must be prepared to welcome this new knowledge, reflecting on the positive and negative aspects of the latest achievements in the field ofgenetics. We hope that the experts dealing with human genetics in Croatia will successfully continue their work to enable practical application of the latest achievements in genetics, expanding our understanding of the concept of health and disease.

  2. Interpersonal Expectancy Effects: A Forty Year Perspective.

    ERIC Educational Resources Information Center

    Rosenthal, Robert

    Interpersonal expectancy effects--the unintentional expectations that experimenters, teachers, and authority figures bring to experiments, classrooms, and other situations--can wield significant influence on individuals. Some of the issues surrounding expectancy effects are detailed in this paper. The effect itself has been recreated in…

  3. Forty Years Later: Updating the Fossilization Hypothesis

    ERIC Educational Resources Information Center

    Han, ZhaoHong

    2013-01-01

    A founding concept in second language acquisition (SLA) research, fossilization has been fundamental to understanding second language (L2) development. The Fossilization Hypothesis, introduced in Selinker's seminal text (1972), has thus been one of the most influential theories, guiding a significant bulk of SLA research for four decades; 2012…

  4. Frequency Allocation: The First Forty Years

    NASA Astrophysics Data System (ADS)

    Robinson, Brian

    In 1960 ICSU set up an Inter-Union Commission (IUCAF) on the Allocation of Frequencies for Space Research and Radio Astronomy, to keep key parts of the radio spectrum clear for passive, scientific use. IUCAF represents URSI, IAU and COSPAR at World Radio Conferences (WRCs) convened by the International Telecommunications Union (ITU) in Geneva; the WRCs establish the international law which governs users of the radio spectrum. This review recounts many serious threats posed to passive scientific research by commercial and military operations, particularly those involving radio emissions from aircraft and spacecraft. The continual conflict between commercial greed and scientific curiosity has often put the future of radio astronomy, space research, and earth exploration in jeopardy. The conflict increases as we move into the Information Age.

  5. Forty Years of Research on Isolated Galaxies

    NASA Astrophysics Data System (ADS)

    Sulentic, J.

    2010-10-01

    Isolated galaxies have not been a hot topic over the past four decades. This is partly due to uncertainties about their existence. Are there galaxies isolated enough to be interesting? Do they exist in sufficient numbers to be statistically useful? Most attempts to compile isolated galaxy lists were marginally successful-too small number and not very isolated galaxies. If really isolated galaxies do exist then their value becomes obvious in a Universe where effects of interactions and environment (i.e. nurture) are important. They provide a means for better quantifying effects of nurture. The Catalog of Isolated Galaxies (CIG) compiled by Valentina Karachentseva appeared near the beginning of the review period. It becomes the focus of this review because of its obvious strengths and because the AMIGA project has increased its utility through a refinement (a vetted CIG). It contains almost 1000 galaxies with nearest neighbor crossing times of 1--3 Gyr. It is large enough to serve as a zero-point or control sample. The galaxies in the CIG (and the distribution of galaxy types) may be significantly different than those in even slightly richer environments. The AMIGA-CIG, and future iterations, may be able to tell us something about galaxy formation. It may also allow us to better define intrinsic (natural) correlations like e.g. Fisher-Tully and FIR-OPTICAL. Correlations can be better defined when the dispersion added by external stimuli (nurture) is minimized or removed.

  6. Forty Years of "Fire in the Belly"

    ERIC Educational Resources Information Center

    Pember, Mary Annette

    2012-01-01

    As in the early days of the tribal college movement, tribal, federal, state, and private funding are still scarce. Fortunately, the founders of the movement, as well as those who worked at tribal colleges in the early days, created a template for others to follow. And tribal colleges and universities (TCUs) continue to turn out new leaders who are…

  7. Neurostimulation of the Lacrimal Nerve for Enhanced Tear Production

    PubMed Central

    Kossler, Andrea L.; Wang, Jianhua; Feuer, William; Tse, David T.

    2014-01-01

    Purpose To design a proof-of-concept study to assess the effect of lacrimal nerve stimulation (LNS) with an implantable pulse generator (IPG) to increase aqueous tear production. Methods Experimental animal study design of six Dutch Belted rabbits. Ultra high-resolution optical coherence tomography (UHR-OCT) quantified tear production by measuring the baseline tear volume of each rabbit’s right and left eye. A neurostimulator was implanted adjacent to the right lacrimal nerve. After two minutes of LNS (100 μs, 1.6 mAmp, 20 Hz, 5–8 volts), the tear volumes were measured with UHR-OCT. The change in tear volume was quantified and compared to the non-stimulated left eye. Three rabbits underwent chronic LNS (100 μS, 1.6 mAmp, 10 Hz, 2 volts) and their lacrimal glands were harvested for histopathologic analysis. Results UHR-OCT imaging of the right eyes tear volume showed a 441% average increase in tear production after LNS as a percent of baseline. After stimulation, right eyes had statistically significant greater increase in tear volumes than left eyes (p=0.028, Wilcoxon test). Post-stimulation right eye tear volumes were significantly greater compared to baseline (p=0.028, Wilcoxon test). Histopathologic examination of the lacrimal glands showed no discernible tissue damage from chronic neurostimulation. Additionally, there were no gross adverse effects on the general well-beings of the animals due to chronic stimulation. Conclusions Lacrimal nerve stimulation with an implantable pulse generator appears to increase aqueous tear production. Chronic LNS showed no histopathologic lacrimal gland damage. This study suggests LNS is a promising new treatment strategy to increase aqueous tear production. PMID:25126767

  8. Neuro-stimulation Techniques for the Management of Anxiety Disorders: An Update

    PubMed Central

    Kar, Sujita Kumar; Sarkar, Siddharth

    2016-01-01

    Neuro-stimulation techniques have gradually evolved over the decades and have emerged potential therapeutic modalities for the treatment of psychiatric disorders, especially treatment refractory cases. The neuro-stimulation techniques involves modalities like electroconvulsive therapy (ECT), repetitive transcranial magnetic stimulation (rTMS), transcranial direct current stimulation (tDCS), vagus nerve stimulation (VNS) and others. This review discusses the role of neuro-stimulation techniques in the treatment of anxiety disorders. The various modalities of neuro-stimulation techniques are briefly discussed. The evidence base relating to use of these techniques in the treatment of anxiety disorders is discussed further. The review then highlights the challenges in conducting research in relation to the use of neuro-stimulation techniques with reference to patients with anxiety disorders. The review provides the future directions of research and aimed at expanding the evidence base of treatment of anxiety disorders and providing neuro-stimulation techniques as promising effective and acceptable alternative in select cases. PMID:27776384

  9. Neurostimulation for primary headache disorders: Part 2, review of central neurostimulators for primary headache, overall therapeutic efficacy, safety, cost, patient selection, and future research in headache neuromodulation.

    PubMed

    Jenkins, Brian; Tepper, Stewart J

    2011-10-01

    This article is the second of 2 articles reviewing neurostimulation for primary headaches. In Part 1, we described methods, pathophysiology and anatomy, and history of neuromodulation in the treatment of headache, as well as reviewing the literature on peripheral neuromodulation for primary headaches. Peripheral targets for stimulation include percutaneous nerves, transcranial holocephalic, occipital nerves, auriculotemporal nerves, supraorbital nerves, cervical epidural, and sphenopalatine ganglia. In Part 2, we describe available literature on central neuromodulation in primary headaches. Central stimulation targets include vagus nerve and deep brain structures. Part 2 also analyzes overall therapeutic efficacy, safety, cost, patient selection, and recommendations for further research of neurostimulation modalities based on available data.

  10. Fabrication and Calibration of FORTIS

    NASA Technical Reports Server (NTRS)

    Fleming, Brian T.; McCandliss, Stephan R.; Kaiser, Mary Elizabeth; Kruk, Jeffery; Feldman, Paul D.; Kutyrev, Alexander S.; Li, Mary J.; Rapchun, David A.; Lyness, Eric; Moseley, S. H.; Siegmund, Oswald; Vallerga, John; Martin, Adrian

    2011-01-01

    The Johns Hopkins University sounding rocket group is entering the final fabrication phase of the Far-ultraviolet Off Rowland-circle Telescope for Imaging and Spectroscopy (FORTIS); a sounding rocket borne multi-object spectro-telescope designed to provide spectral coverage of 43 separate targets in the 900 - 1800 Angstrom bandpass over a 30' x 30' field-of-view. Using "on-the-fly" target acquisition and spectral multiplexing enabled by a GSFC microshutter array, FORTIS will be capable of observing the brightest regions in the far-UV of nearby low redshift (z approximately 0.002 - 0.02) star forming galaxies to search for Lyman alpha escape, and to measure the local gas-to-dust ratio. A large area (approximately 45 mm x 170 mm) microchannel plate detector built by Sensor Sciences provides an imaging channel for targeting flanked by two redundant spectral outrigger channels. The grating is ruled directly onto the secondary mirror to increase efficiency. In this paper, we discuss the recent progress made in the development and fabrication of FORTIS, as well as the results of early calibration and characterization of our hardware, including mirror/grating measurements, detector performance, and early operational tests of the micro shutter arrays.

  11. An implantable neurostimulator with an integrated high-voltage inductive power-recovery frontend

    NASA Astrophysics Data System (ADS)

    Yuan, Wang; Xu, Zhang; Ming, Liu; Peng, Li; Hongda, Chen

    2014-10-01

    This paper present a highly-integrated neurostimulator with an on-chip inductive power-recovery frontend and high-voltage stimulus generator. In particular, the power-recovery frontend includes a high-voltage full-wave rectifier (up to 100 V AC input), high-voltage series regulators (24/5 V outputs) and a linear regulator (1.8/3.3 V output) with bandgap voltage reference. With the high voltage output of the series regulator, the proposed neurostimulator could deliver a considerably large current in high electrode-tissue contact impedance. This neurostimulator has been fabricated in a CSMC 1 μm 5/40/700 V BCD process and the total silicon area including pads is 5.8 mm2. Preliminary tests are successful as the neurostimulator shows good stability under a 13.56 MHz AC supply. Compared to previously reported works, our design has advantages of a wide induced voltage range (26-100 V), high output voltage (up to 24 V) and high-level integration, which are suitable for implantable neurostimulators.

  12. Neurostimulation to improve level of consciousness in patients with epilepsy.

    PubMed

    Gummadavelli, Abhijeet; Kundishora, Adam J; Willie, Jon T; Andrews, John P; Gerrard, Jason L; Spencer, Dennis D; Blumenfeld, Hal

    2015-06-01

    When drug-resistant epilepsy is poorly localized or surgical resection is contraindicated, current neurostimulation strategies such as deep brain stimulation and vagal nerve stimulation can palliate the frequency or severity of seizures. However, despite medical and neuromodulatory therapy, a significant proportion of patients continue to experience disabling seizures that impair awareness, causing disability and risking injury or sudden unexplained death. We propose a novel strategy in which neuromodulation is used not only to reduce seizures but also to ameliorate impaired consciousness when the patient is in the ictal and postictal states. Improving or preventing alterations in level of consciousness may have an effect on morbidity (e.g., accidents, drownings, falls), risk for death, and quality of life. Recent studies may have elucidated underlying networks and mechanisms of impaired consciousness and yield potential novel targets for neuromodulation. The feasibility, benefits, and pitfalls of potential deep brain stimulation targets are illustrated in human and animal studies involving minimally conscious/vegetative states, movement disorders, depth of anesthesia, sleep-wake regulation, and epilepsy. We review evidence that viable therapeutic targets for impaired consciousness associated with seizures may be provided by key nodes of the consciousness system in the brainstem reticular activating system, hypothalamus, basal ganglia, thalamus, and basal forebrain.

  13. Optimization of magnetic neurostimulation waveforms for minimum power loss.

    PubMed

    Goetz, S M; Truong, N C; Gerhofer, M G; Peterchev, A V; Herzog, H-G; Weyh, T

    2012-01-01

    Magnetic stimulation is a key tool in experimental brain research and several clinical applications. Whereas coil designs and the spatial field properties have been intensively studied in the literature, the temporal dynamics of the field has received little attention. The available pulse shapes are typically determined by the relatively limited capabilities of commercial stimulation devices instead of efficiency or optimality. Furthermore, magnetic stimulation is relatively inefficient with respect to the required energy compared to other neurostimulation techniques. We therefore analyze and optimize the waveform dynamics with a nonlinear model of a mammalian motor axon for the first time, without any pre-definition of waveform candidates. We implemented an unbiased and stable numerical algorithm using variational calculus in combination with a global optimization method. This approach yields very stable results with comprehensible characteristic properties, such as a first phase which reduces ohmic losses in the subsequent pulse phase. We compare the energy loss of these optimal waveforms with the waveforms generated by existing magnetic stimulation devices.

  14. Neurostimulation in Alzheimer's disease: from basic research to clinical applications.

    PubMed

    Nardone, Raffaele; Höller, Yvonne; Tezzon, Frediano; Christova, Monica; Schwenker, Kerstin; Golaszewski, Stefan; Trinka, Eugen; Brigo, Francesco

    2015-05-01

    The development of different methods of brain stimulation provides a promising therapeutic tool with potentially beneficial effects on subjects with impaired cognitive functions. We performed a systematic review of the studies published in the field of neurostimulation in Alzheimer's disease (AD), from basic research to clinical applications. The main methods of non-invasive brain stimulation are repetitive transcranial magnetic stimulation and transcranial direct current stimulation. Preliminary findings have suggested that both techniques can enhance performances on several cognitive functions impaired in AD. Another non-invasive emerging neuromodulatory approach, the transcranial electromagnetic treatment, was found to reverse cognitive impairment in AD transgenic mice and even improves cognitive performance in normal mice. Experimental studies suggest that high-frequency electromagnetic fields may be critically important in AD prevention and treatment through their action at mitochondrial level. Finally, the application of a widely known invasive technique, the deep brain stimulation (DBS), has increasingly been considered as a therapeutic option also for patients with AD; it has been demonstrated that DBS of fornix/hypothalamus and nucleus basalis of Meynert might improve or at least stabilize cognitive functioning in AD. Initial encouraging results provide support for continuing to investigate non-invasive and invasive brain stimulation approaches as an adjuvant treatment for AD patients.

  15. Longitudinal Neurostimulation in Older Adults Improves Working Memory

    PubMed Central

    Jones, Kevin T.; Stephens, Jaclyn A.; Alam, Mahtab; Bikson, Marom; Berryhill, Marian E.

    2015-01-01

    An increasing concern affecting a growing aging population is working memory (WM) decline. Consequently, there is great interest in improving or stabilizing WM, which drives expanded use of brain training exercises. Such regimens generally result in temporary WM benefits to the trained tasks but minimal transfer of benefit to untrained tasks. Pairing training with neurostimulation may stabilize or improve WM performance by enhancing plasticity and strengthening WM-related cortical networks. We tested this possibility in healthy older adults. Participants received 10 sessions of sham (control) or active (anodal, 1.5 mA) tDCS to the right prefrontal, parietal, or prefrontal/parietal (alternating) cortices. After ten minutes of sham or active tDCS, participants performed verbal and visual WM training tasks. On the first, tenth, and follow-up sessions, participants performed transfer WM tasks including the spatial 2-back, Stroop, and digit span tasks. The results demonstrated that all groups benefited from WM training, as expected. However, at follow-up 1-month after training ended, only the participants in the active tDCS groups maintained significant improvement. Importantly, this pattern was observed for both trained and transfer tasks. These results demonstrate that tDCS-linked WM training can provide long-term benefits in maintaining cognitive training benefits and extending them to untrained tasks. PMID:25849358

  16. Facial Pain Update: Advances in Neurostimulation for the Treatment of Facial Pain.

    PubMed

    Maniam, Rajivan; Kaye, Alan David; Vadivelu, Nalini; Urman, Richard D

    2016-04-01

    Craniofacial pain, including trigeminal neuralgia, trigeminal neuropathic pain, and persistent idiopathic facial pain, is difficult to treat and can have severe implications for suffering in patients afflicted with these conditions. In recent years, clinicians have moved beyond treating solely with pharmacological therapies, which are generally not very effective, and focused on new interventional pain procedures. These procedures have evolved as technology has advanced, and thus far, early results have demonstrated efficacy in small patient cohorts with a variety of craniofacial pain states. Some of the most promising interventional pain procedures include peripheral nerve field stimulation, high-frequency spinal cord stimulation, sphenopalatine ganglion stimulation, and deep brain stimulation. This review focuses on a better understanding of craniofacial pain and emerging interventional pain therapies. With the advent of newer miniature wireless devices and less invasive implantation techniques, this should allow for more widespread use of neurostimulation as a therapeutic modality for treating craniofacial pain. Larger studies should assist in best practice strategies vis-à-vis traditional pharmacological therapies and emerging interventional pain techniques.

  17. Can Nanofluidic Chemical Release Enable Fast, High Resolution Neurotransmitter-Based Neurostimulation?

    PubMed Central

    Jones, Peter D.; Stelzle, Martin

    2016-01-01

    Artificial chemical stimulation could provide improvements over electrical neurostimulation. Physiological neurotransmission between neurons relies on the nanoscale release and propagation of specific chemical signals to spatially-localized receptors. Current knowledge of nanoscale fluid dynamics and nanofluidic technology allows us to envision artificial mechanisms to achieve fast, high resolution neurotransmitter release. Substantial technological development is required to reach this goal. Nanofluidic technology—rather than microfluidic—will be necessary; this should come as no surprise given the nanofluidic nature of neurotransmission. This perspective reviews the state of the art of high resolution electrical neuroprostheses and their anticipated limitations. Chemical release rates from nanopores are compared to rates achieved at synapses and with iontophoresis. A review of microfluidic technology justifies the analysis that microfluidic control of chemical release would be insufficient. Novel nanofluidic mechanisms are discussed, and we propose that hydrophobic gating may allow control of chemical release suitable for mimicking neurotransmission. The limited understanding of hydrophobic gating in artificial nanopores and the challenges of fabrication and large-scale integration of nanofluidic components are emphasized. Development of suitable nanofluidic technology will require dedicated, long-term efforts over many years. PMID:27065794

  18. CMOS neurostimulation ASIC with 100 channels, scaleable output, and bidirectional radio-frequency telemetry.

    PubMed

    Suaning, G J; Lovell, N H

    2001-02-01

    100-channel neurostimulation circuit comprising a complementary metal oxide semiconductor (CMOS), application-specific integrated circuit (ASIC) has been designed, constructed and tested. The ASIC forms a significant milestone and an integral component of a 100-electrode neurostimulation system being developed by the authors. The system comprises an externally worn transmitter and a body implantable stimulator. The purpose of the system is to communicate both data and power across tissue via radio-frequency (RF) telemetry such that externally programmable, constant current, charge balanced, biphasic stimuli may be delivered to neural tissue at 100 unique sites. An intrinsic reverse telemetry feature of the ASIC has been designed such that information pertaining to the device function, reconstruction of the stimulation voltage waveform, and the measurement of impedance may be obtained through noninvasive means. To compensate for the paucity of data pertaining to the stimulation thresholds necessary in evoking a physiological response, the ASIC has been designed with scaleable current output. The ASIC has been designed primarily as a treatment of degenerative disorders of the retina whereby the 100 channels are to be utilized in the delivery of a pattern of stimuli of varying intensity and or duty cycle to the surviving neural tissue of the retina. However, it is conceivable that other fields of neurostimulation such as cochlear prosthetics and functional electronic stimulation may benefit from the employment of the system.

  19. Pre-frontal control of closed-loop limbic neurostimulation by rodents using a brain-computer interface

    NASA Astrophysics Data System (ADS)

    Widge, Alik S.; Moritz, Chet T.

    2014-04-01

    Objective. There is great interest in closed-loop neurostimulators that sense and respond to a patient's brain state. Such systems may have value for neurological and psychiatric illnesses where symptoms have high intraday variability. Animal models of closed-loop stimulators would aid preclinical testing. We therefore sought to demonstrate that rodents can directly control a closed-loop limbic neurostimulator via a brain-computer interface (BCI). Approach. We trained rats to use an auditory BCI controlled by single units in prefrontal cortex (PFC). The BCI controlled electrical stimulation in the medial forebrain bundle, a limbic structure involved in reward-seeking. Rigorous offline analyses were performed to confirm volitional control of the neurostimulator. Main results. All animals successfully learned to use the BCI and neurostimulator, with closed-loop control of this challenging task demonstrated at 80% of PFC recording locations. Analysis across sessions and animals confirmed statistically robust BCI control and specific, rapid modulation of PFC activity. Significance. Our results provide a preliminary demonstration of a method for emotion-regulating closed-loop neurostimulation. They further suggest that activity in PFC can be used to control a BCI without pre-training on a predicate task. This offers the potential for BCI-based treatments in refractory neurological and mental illness.

  20. Forty Years of Education: Will the Next Forty Be Any Better?

    ERIC Educational Resources Information Center

    Grambs, Jean Dresden

    1981-01-01

    Ponders the transitory nature of some educational innovations, the resistence of the school system to outside forces, and two conditions without precedence: the reality of nuclear weapons and the women's movement. (MLF)

  1. Long-term measurement of impedance in chronically implanted depth and subdural electrodes during responsive neurostimulation in humans.

    PubMed

    Sillay, Karl A; Rutecki, Paul; Cicora, Kathy; Worrell, Greg; Drazkowski, Joseph; Shih, Jerry J; Sharan, Ashwini D; Morrell, Martha J; Williams, Justin; Wingeier, Brett

    2013-09-01

    Long-term stability of the electrode-tissue interface may be required to maintain optimal neural recording with subdural and deep brain implants and to permit appropriate delivery of neuromodulation therapy. Although short-term changes in impedance at the electrode-tissue interface are known to occur, long-term changes in impedance have not previously been examined in detail in humans. To provide further information about short- and long-term impedance changes in chronically implanted electrodes, a dataset from 191 persons with medically intractable epilepsy participating in a trial of an investigational responsive neurostimulation device (the RNS(®) System, NeuroPace, Inc.) was reviewed. Monopolar impedance measurements were available for 391 depth and subdural leads containing a total of 1564 electrodes; measurements were available for median 802 days post-implant (range 28-1634). Although there were statistically significant short-term impedance changes, long-term impedance was stable after one year. Impedances for depth electrodes transiently increased during the third week after lead implantation and impedances for subdural electrodes increased over 12 weeks post-implant, then were stable over the subsequent long-term follow-up. Both depth and subdural electrode impedances demonstrated long-term stability, suggesting that the quality of long-term electrographic recordings (the data used to control responsive brain stimulation) can be maintained over time.

  2. Toward a fully integrated neurostimulator with inductive power recovery front-end.

    PubMed

    Mounaïm, Fayçal; Sawan, Mohamad

    2012-08-01

    In order to investigate new neurostimulation strategies for micturition recovery in spinal cord injured patients, custom implantable stimulators are required to carry-on chronic animal experiments. However, higher integration of the neurostimulator becomes increasingly necessary for miniaturization purposes, power consumption reduction, and for increasing the number of stimulation channels. As a first step towards total integration, we present in this paper the design of a highly-integrated neurostimulator that can be assembled on a 21-mm diameter printed circuit board. The prototype is based on three custom integrated circuits fabricated in High-Voltage (HV) CMOS technology, and a low-power small-scale commercially available FPGA. Using a step-down approach where the inductive voltage is left free up to 20 V, the inductive power and data recovery front-end is fully integrated. In particular, the front-end includes a bridge rectifier, a 20-V voltage limiter, an adjustable series regulator (5 to 12 V), a switched-capacitor step-down DC/DC converter (1:3, 1:2, or 2:3 ratio), as well as data recovery. Measurements show that the DC/DC converter achieves more than 86% power efficiency while providing around 3.9-V from a 12-V input at 1-mA load, 1:3 conversion ratio, and 50-kHz switching frequency. With such efficiency, the proposed step-down inductive power recovery topology is more advantageous than its conventional step-up counterpart. Experimental results confirm good overall functionality of the system.

  3. Toward a Symptom-Guided Neurostimulation for Gilles de la Tourette Syndrome

    PubMed Central

    Pedroarena-Leal, Nicole; Ruge, Diane

    2017-01-01

    Therapy resistance of approximately one-third of patients with Gilles de la Tourette syndrome (GTS) requires consideration of alternative therapeutic interventions. This article provides a condensed review of the invasive and non-invasive stimulation techniques that have been applied, to date, for treatment and investigation of GTS. Through this perspective and short review, the article discusses potential novel applications for neurostimulation techniques based on a symptom-guided approach. The concept of considering the physiological basis of specific symptoms when using stimulation techniques will provide a platform for more effective non-pharmacological neuromodulation of symptoms in GTS. PMID:28289393

  4. Ipsi- and Contralateral Motor Response Using Ultrasound-induced Neurostimulation in Deeply Anesthetized Mice

    NASA Astrophysics Data System (ADS)

    Kamimura, Hermes; Wang, Shutao; Chen, Hong; Wang, Qi; Aurup, Christian; Fan, Kathtleen; Carneiro, Antonio; Konofagou, Elisa

    Ultrasound neurostimulation has been proven capable of eliciting motor responses. However, the studies in sedated rodents presented problems with target specificity due to the use of low ultrasound frequencies (<700 kHz). Here, we show that focused ultrasound (FUS) in mega-Hz range was able to evoke motor responses in mice under deep anesthesia. Contralateral movements of the hind limbs were observed when sonications were carried out at +2 mm of Lambda and ±2 mm lateral of midline in three mice. Moreover, stimulating other regions of the somatosensory and cerebellum induced trunk and ipsilateral limb movements in all six mice.

  5. Forties oil line replacement overcomes sandwave challenge

    SciTech Connect

    Steel, W.J.M.; Imglis, R. )

    1991-03-06

    A major new 36-in., oil-export pipeline has been installed in the North Sea between the Forties field and Cruden Bay on the U.K. mainland. Designing and installing the line involved solving problems caused by sandwaves in the nearshore segment of the route. The Forties pipeline system covers offshore and land pipelines between the Forties field and the Firth of Forth tanker loading terminal and incorporates oil transportation, stabilization-gas separation, processing, and storage. The pipeline is used as part of an integrated oil and gas liquid gathering system from the central North Sea. Oil and gas liquids from other offshore fields are connected by subsea pipelines and riser to the Forties Charlie platform. Inspection of the existing 32-in. offshore pipeline had indicated signs of corrosion which would prevent the system from operating economically as future demands increased. In addition, when the line was commissioned in 1975, it was not envisioned that it would eventually carry crude from several other fields, which will come onstream this decade. The decision to lay a new 36-in. sealine reflects this need for increased capacity to ensure that the Forties pipeline system continues as a major carrier of oil and gas liquids well into the next century. Corrosion monitoring and inspection of the 32-in. line led to sections of the topside pipework being replaced in 1985 and the top section of the rise in 1987. The corrosion also resulted in the pipeline maximum allowable operating pressure (MAOP) being limited to 115 barg (1,668 psig) from 129 barg (1,871 psig).

  6. An Investigation into Nine General Areas and Forty-four Specific Sub-Areas of Physical Education Currently in Existence Within the Two Year Institutions of Higher Learning Within the Continental United States, 1970-1971.

    ERIC Educational Resources Information Center

    Stier, William F., Jr.

    The purpose of this study was to ascertain the present status of programs in 2-year college physical education departments. Questionnaires were sent to a national sample of 140 institutions; 74 or 53% were returned. Besides noting the size of the departments, the type of governance of the schools, and the size of the college communities, data on…

  7. ZigBee-based Wireless Neuro-Stimulator for Improving Stroke Recovery.

    PubMed

    Kim, Gookhwa; Yun, Hyojeong; Ryu, Munho; Shin, Yongil; Kim, Hyoungihl; Yang, Yoonseok

    2010-12-01

    Stroke is a leading cause of adult disability and the second-leading cause of death in Korea. It is also the third-leading cause of death in the United States, leading to a serious demand for new interventions to improve the quality of life in stroke survivors. To this end, direct cortical stimulation using an epidural electrode has been reported with promising results in animal and human studies, showing the potential for enhancing the recovery in chronic stroke patients. For optimal results, doctors must be able to modify the stimulation pattern as frequently as needed over a period of time for a given patient. However, severe aftereffects caused by stroke limit patients' activities, making regular doctor visits for treatment difficult. This study aims to develop a prototype of a telemedicine system to enhance stroke recovery by using a ZigBeebased wireless neuro-stimulator. The ZigBee is a stable platform for many low-power wireless applications. To allow stroke patients to remotely obtain neuro-stimulation treatments from their doctors, we connected the ZigBee to the internet. The system also allows doctors to personalize treatment based on the history of the stimulation parameters. The system developed here can also be beneficial as a common platform for a wide range of brain diseases and clinical care for which electric stimulation is used.

  8. Boosting brain functions: Improving executive functions with behavioral training, neurostimulation, and neurofeedback.

    PubMed

    Enriquez-Geppert, Stefanie; Huster, René J; Herrmann, Christoph S

    2013-04-01

    Cognitive enhancement is a popular topic, attracting attention both from the general public and the scientific research community. Higher cognitive functions are involved in various aspects of everyday life and have been associated with manifest behavioral and psychiatric mental impairments when deteriorated. The improvement of these so-called executive functions (EFs) is of high individual, social, and economic relevances. This review provides a synopsis of two lines of research, investigating the enhancement of capabilities in executive functioning: a) computerized behavioral trainings, and b) approaches for direct neuromodulation (neurofeedback and transcranial electrostimulation). Task switching, memory updating, response inhibition, and dual task performance are addressed in terms of cognitive functions. It has been shown that behavioral cognitive training leads to enhanced performance in task switching, memory updating, and dual tasks. Similarly, direct neurocognitive modulation of brain regions that are crucially involved in specific EFs also leads to behavioral benefits in response inhibition, task switching, and memory updating. Response inhibition performance has been shown to be improved by neurostimulation of the right inferior frontal cortex, whereas neurostimulation of the dorsolateral prefrontal cortex exerts effects on task switching and memory updating. Due to a lack of consistency in experimental methods and findings, a comparison of different training approaches concerning their effectiveness is not yet possible. So far, current data suggest that training gains may indeed generalize to untrained tasks aiming at the same cognitive process, as well as across cognitive domains within executive control.

  9. Improved Anatomical Specificity of Non-invasive Neuro-stimulation by High Frequency (5 MHz) Ultrasound

    NASA Astrophysics Data System (ADS)

    Li, Guo-Feng; Zhao, Hui-Xia; Zhou, Hui; Yan, Fei; Wang, Jing-Yao; Xu, Chang-Xi; Wang, Cong-Zhi; Niu, Li-Li; Meng, Long; Wu, Song; Zhang, Huai-Ling; Qiu, Wei-Bao; Zheng, Hai-Rong

    2016-04-01

    Low frequency ultrasound (<1 MHz) has been demonstrated to be a promising approach for non-invasive neuro-stimulation. However, the focal width is limited to be half centimeter scale. Minimizing the stimulation region with higher frequency ultrasound will provide a great opportunity to expand its application. This study first time examines the feasibility of using high frequency (5 MHz) ultrasound to achieve neuro-stimulation in brain, and verifies the anatomical specificity of neuro-stimulation in vivo. 1 MHz and 5 MHz ultrasound stimulation were evaluated in the same group of mice. Electromyography (EMG) collected from tail muscles together with the motion response videos were analyzed for evaluating the stimulation effects. Our results indicate that 5 MHz ultrasound can successfully achieve neuro-stimulation. The equivalent diameter (ED) of the stimulation region with 5 MHz ultrasound (0.29 ± 0.08 mm) is significantly smaller than that with 1 MHz (0.83 ± 0.11 mm). The response latency of 5 MHz ultrasound (45 ± 31 ms) is also shorter than that of 1 MHz ultrasound (208 ± 111 ms). Consequently, high frequency (5 MHz) ultrasound can successfully activate the brain circuits in mice. It provides a smaller stimulation region, which offers improved anatomical specificity for neuro-stimulation in a non-invasive manner.

  10. Improved Anatomical Specificity of Non-invasive Neuro-stimulation by High Frequency (5 MHz) Ultrasound

    PubMed Central

    Li, Guo-Feng; Zhao, Hui-Xia; Zhou, Hui; Yan, Fei; Wang, Jing-Yao; Xu, Chang-Xi; Wang, Cong-Zhi; Niu, Li-Li; Meng, Long; Wu, Song; Zhang, Huai-Ling; Qiu, Wei-Bao; Zheng, Hai-Rong

    2016-01-01

    Low frequency ultrasound (<1 MHz) has been demonstrated to be a promising approach for non-invasive neuro-stimulation. However, the focal width is limited to be half centimeter scale. Minimizing the stimulation region with higher frequency ultrasound will provide a great opportunity to expand its application. This study first time examines the feasibility of using high frequency (5 MHz) ultrasound to achieve neuro-stimulation in brain, and verifies the anatomical specificity of neuro-stimulation in vivo. 1 MHz and 5 MHz ultrasound stimulation were evaluated in the same group of mice. Electromyography (EMG) collected from tail muscles together with the motion response videos were analyzed for evaluating the stimulation effects. Our results indicate that 5 MHz ultrasound can successfully achieve neuro-stimulation. The equivalent diameter (ED) of the stimulation region with 5 MHz ultrasound (0.29 ± 0.08 mm) is significantly smaller than that with 1 MHz (0.83 ± 0.11 mm). The response latency of 5 MHz ultrasound (45 ± 31 ms) is also shorter than that of 1 MHz ultrasound (208 ± 111 ms). Consequently, high frequency (5 MHz) ultrasound can successfully activate the brain circuits in mice. It provides a smaller stimulation region, which offers improved anatomical specificity for neuro-stimulation in a non-invasive manner. PMID:27093909

  11. Path integration in desert ants, Cataglyphis fortis

    PubMed Central

    Müller, Martin; Wehner, Rüdiger

    1988-01-01

    Foraging desert ants, Cataglyphis fortis, continually keep track of their own posotions relative to home— i.e., integrate their tortuous outbound routes and return home along straight (inbound) routes. By experimentally manipulating the ants' outbound trajectories we show that the ants solve this path integration problem not by performing a true vector summation (as a human navigator does) but by employing a computationally simple approximation. This approximation is characterized by small, but systematic, navigational errors that helped us elucidate the ant's way of computing its mean home vector. PMID:16593958

  12. Forty-Year "Drift" and Change of the SAA

    NASA Technical Reports Server (NTRS)

    Stassinopoulos, Epaminondas G,; Xapsos, Michael A.; Stauffer, Craig A.

    2015-01-01

    A comprehensive study was conducted to evaluate the change in the location and size of the South Atlantic Anomaly (SAA) as a function of time, primarily in relation to trapped Van Allen Belt proton populations. The study was limited to one altitude only (800 km), which is still within the Earth's atmosphere but is removed from the atmospheric cut-off level located at about 100-200 km.

  13. Renal radionuclide imaging, an evergreen forty years old.

    PubMed

    De Palma, D; Santos, A I

    2014-07-01

    Urinary tract congenital abnormalities (UCA) and febrile infections (UTI) are, respectively, 2 of the commonest congenital and acquired health problems in childhood. In both, radionuclide imaging still represent a cornerstone of diagnostic imaging, although the involved techniques are more or less the same from the early '80 s. During the last 2 decades, published papers focused on a deep revision about the optimal use and usefulness of such imaging tools in affected children, with the aim of reducing invasiveness, radiation burden and costs without losing efficacy. This approach leads to different results. In UCA, no consensus for a diagnostic algorithm was up to now reached, whilst, about febrile UTIs, guidelines were published in 2007 by the UK's National Institute for Clinical Excellence (NICE) and by the European Society of Paediatric Radiology (ESPR), in 2011 by the American Academy of Paediatrics (AAP), and in 2012 by the Italian Society of Paediatric Nephrology (SINP). Nevertheless, new data continuously arise and the scientific debate always revives. Every imaging tool now available has its own strengths and weaknesses, and so all published guidelines. All this body of knowledge must be critically analysed for obtaining a complete, up-to-date and flexible overview about these "always hot" topics.

  14. Forty Years of Teacher Education in Australia: 1974-2014

    ERIC Educational Resources Information Center

    Mayer, Diane

    2014-01-01

    In this paper, I analyse the history of teacher education in Australia from 1974 to the current policy moment in which questions are increasingly being asked about the quality of teaching and teacher education. Teacher education is, and has been, a highly scrutinised domain in Australia. Since the 1970s, we have seen more than 100 reviews of…

  15. Forty-Five Years of Marburg Virus Research

    PubMed Central

    Brauburger, Kristina; Hume, Adam J.; Mühlberger, Elke; Olejnik, Judith

    2012-01-01

    In 1967, the first reported filovirus hemorrhagic fever outbreak took place in Germany and the former Yugoslavia. The causative agent that was identified during this outbreak, Marburg virus, is one of the most deadly human pathogens. This article provides a comprehensive overview of our current knowledge about Marburg virus disease ranging from ecology to pathogenesis and molecular biology. PMID:23202446

  16. Forty-five years of Marburg virus research.

    PubMed

    Brauburger, Kristina; Hume, Adam J; Mühlberger, Elke; Olejnik, Judith

    2012-10-01

    In 1967, the first reported filovirus hemorrhagic fever outbreak took place in Germany and the former Yugoslavia. The causative agent that was identified during this outbreak, Marburg virus, is one of the most deadly human pathogens. This article provides a comprehensive overview of our current knowledge about Marburg virus disease ranging from ecology to pathogenesis and molecular biology.

  17. Changes in Patterns of Health Care: Plus Forty Years

    ERIC Educational Resources Information Center

    Sofalvi, Alan J.

    2010-01-01

    In this article, the author presents an update of Herman's article ["Changes in Patterns of Health Care," "School Health Review," 1(9-14)1969] that focuses on the changes in patterns of health care. He discusses the poverty, insurance, and access to medical care as well as the quality of medical care for adults and minors. He stresses that…

  18. Forty-five years of cell-cycle genetics

    PubMed Central

    Reid, Brian J.; Culotti, Joseph G.; Nash, Robert S.; Pringle, John R.

    2015-01-01

    In the early 1970s, studies in Leland Hartwell’s laboratory at the University of Washington launched the genetic analysis of the eukaryotic cell cycle and set the path that has led to our modern understanding of this centrally important process. This 45th-anniversary Retrospective reviews the steps by which the project took shape, the atmosphere in which this happened, and the possible morals for modern times. It also provides an up-to-date look at the 35 original CDC genes and their human homologues. PMID:26628751

  19. Forty-Year-Old Foam Springs Back With New Benefits

    NASA Technical Reports Server (NTRS)

    2005-01-01

    The most recognized and widely used NASA spinoff is at it again. Temper foam, whose origins date back to 1966 when it was developed to absorb shock and, thus, offer improved protection and comfort in NASA s airplane seats, has paid its dividends to Earth repeatedly, and in many different ways. It has padded the helmets of the Dallas Cowboys throughout the 1970s and 1980s, protected bedridden patients from bedsores, and comforted the feet of thousands wearing stylish shoes that incorporate the cushioning material in their insoles. Four decades later, the world has come to realize that there are no bounds to temper foam s benefits. Though the rights to the technology have been shared amongst various manufacturers, the original product maker is still going strong, pushing temper foam into new arenas, including automotives, amusement parks, prosthetics, and modern art.

  20. Sixty Hertz Neurostimulation Amplifies Subthalamic Neural Synchrony in Parkinson’s Disease

    PubMed Central

    Blumenfeld, Zack; Velisar, Anca; Miller Koop, Mandy; Hill, Bruce C.; Shreve, Lauren A.; Quinn, Emma J.; Kilbane, Camilla; Yu, Hong; Henderson, Jaimie M.; Brontë-Stewart, Helen

    2015-01-01

    High frequency subthalamic nucleus (STN) deep brain stimulation (DBS) improves the cardinal motor signs of Parkinson’s disease (PD) and attenuates STN alpha/beta band neural synchrony in a voltage-dependent manner. While there is a growing interest in the behavioral effects of lower frequency (60 Hz) DBS, little is known about its effect on STN neural synchrony. Here we demonstrate for the first time that during intra-operative 60 Hz STN DBS, one or more bands of resting state neural synchrony were amplified in the STN in PD. We recorded intra-operative STN resting state local field potentials (LFPs) from twenty-eight STNs in seventeen PD subjects after placement of the DBS lead (model 3389, Medtronic, Inc.) before and during three randomized neurostimulation sets (130 Hz/1.35V, 130 Hz/2V, 60 Hz/2V). During 130 Hz/2V DBS, baseline (no DBS) STN alpha (8 – 12 Hz) and beta (13 – 35 Hz) band power decreased (N=14, P < 0.001 for both), whereas during 60 Hz/2V DBS, alpha band and peak frequency power increased (P = 0.012, P = 0.007, respectively). The effect of 60 Hz/2V DBS opposed that of power-equivalent (130 Hz/1.35V) DBS (alpha: P < 0.001, beta: P = 0.006). These results show that intra-operative 60 Hz STN DBS amplified whereas 130 Hz STN DBS attenuated resting state neural synchrony in PD; the effects were frequency-specific. We demonstrate that neurostimulation may be useful as a tool to selectively modulate resting state resonant bands of neural synchrony and to investigate its influence on motor and non-motor behaviors in PD and other neuropsychiatric diseases. PMID:25807463

  1. An Arbitrary Waveform Wearable Neuro-stimulator System for Neurophysiology Research on Freely Behaving Animals

    PubMed Central

    Samani, Mohsen Mosayebi; Mahnam, Amin; Hosseini, Nasrin

    2014-01-01

    Portable wireless neuro-stimulators have been developed to facilitate long-term cognitive and behavioral studies on the central nervous system in freely moving animals. These stimulators can provide precisely controllable input(s) to the nervous system, without distracting the animal attention with cables connected to its body. In this study, a low power backpack neuro-stimulator was developed for animal brain researches that can provides arbitrary stimulus waveforms for the stimulation, while it is small and light weight to be used for small animals including rats. The system consists of a controller that uses an RF link to program and activate a small and light microprocessor-based stimulator. A Howland current source was implemented to produce precise current controlled arbitrary waveform stimulations. The system was optimized for ultra-low power consumption and small size. The stimulator was first tested for its electrical specifications. Then its performance was evaluated in a rat experiment when electrical stimulation of medial longitudinal fasciculus induced circling behavior. The stimulator is capable of delivering programmed stimulations up to ± 2 mA with adjusting steps of 1 μA, accuracy of 0.7% and compliance of 6 V. The stimulator is 15 mm × 20 mm × 40 mm in size, weights 13.5 g without battery and consumes a total power of only 5.l mW. In the experiment, the rat could easily carry the stimulator and demonstrated the circling behavior for 0.1 ms current pulses of above 400 μA. The developed system has a competitive size and weight, whereas providing a wide range of operation and the flexibility of generating arbitrary stimulation patterns ideal for long-term experiments in the field of cognitive and neuroscience research. PMID:24761373

  2. A High-Voltage-Tolerant and Precise Charge-Balanced Neuro-Stimulator in Low Voltage CMOS Process.

    PubMed

    Luo, Zhicong; Ker, Ming-Dou

    2016-12-01

    This paper presents a 4 × VDD neuro-stimulator in a 0.18- μm 1.8 V/3.3 V CMOS process. The self-adaption bias technique and stacked MOS configuration are used to prevent transistors from the electrical overstress and gate-oxide reliability issue. A high-voltage-tolerant level shifter with power-on protection is used to drive the neuro-stimulator The reliability measurement of up to 100 million periodic cycles with 3000- μA biphasic stimulations in 12-V power supply has verified that the proposed neuro-stimulator is robust. Precise charge balance is achieved by using a novel current memory cell with the dual calibration loops and leakage current compensation. The charge mismatch is down to 0.25% over all the stimulus current ranges (200-300 μA) The residual average dc current is less than 6.6 nA after shorting operation.

  3. Electrically evoked hearing perception by functional neurostimulation of the central auditory system.

    PubMed

    Tatagiba, M; Gharabaghi, A

    2005-01-01

    Perceptional benefits and potential risks of electrical stimulation of the central auditory system are constantly changing due to ongoing developments and technical modifications. Therefore, we would like to introduce current treatment protocols and strategies that might have an impact on functional results of auditory brainstem implants (ABI) in profoundly deaf patients. Patients with bilateral tumours as a result of neurofibromatosis type 2 with complete dysfunction of the eighth cranial nerves are the most frequent candidates for auditory brainstem implants. Worldwide, about 300 patients have already received an ABI through a translabyrinthine or suboccipital approach supported by multimodality electrophysiological monitoring. Patient selection is based on disease course, clinical signs, audiological, radiological and psycho-social criteria. The ABI provides the patients with access to auditory information such as environmental sound awareness together with distinct hearing cues in speech. In addition, this device markedly improves speech reception in combination with lip-reading. Nonetheless, there is only limited open-set speech understanding. Results of hearing function are correlated with electrode design, number of activated electrodes, speech processing strategies, duration of pre-existing deafness and extent of brainstem deformation. Functional neurostimulation of the central auditory system by a brainstem implant is a safe and beneficial procedure, which may considerably improve the quality of life in patients suffering from deafness due to bilateral retrocochlear lesions. The auditory outcome may be improved by a new generation of microelectrodes capable of penetrating the surface of the brainstem to access more directly the auditory neurons.

  4. Interventional neurophysiology and an implantable system for neurostimulation of the sacral area.

    PubMed

    Malaguti, Silvia

    2009-01-01

    Surgical or interventional neurophysiology is a term commonly used to refer to a large number of neurosurgical procedures involving the brain, cranial nerves, spinal cord and peripheral nervous system which, to be efficient and safe, demand specific neurophysiological know-how. As a result of the development of these procedures and their increasing use in the operating room, the role of clinical neurophysiology, traditionally diagnostic, has been extended. With the advent of 'neurostimulation' and 'neuromodulation', some neurophysiological techniques have, in themselves, progressively become more therapeutic, the therapeutic alteration of nervous system activity being achieved not only by surgical ablation or medication but also through electrophysiological means via implanted or non-implanted devices, whose development was made possible by extensive studies in the field of neurophysiology. The first application of electrical stimulation in urology opened up the way for progress in the therapeutic direction. Moreover, with regard to the mechanism of action underlying neuromodulation, the application of neurophysiology and neuroimaging procedures has contributed to understanding of the neural control mechanism of visceral (e.g. lower urinary tract) function. In our experience, the advent of sacral neuromodulation for lower urinary tract dysfunction and the use of neurophysiology has made it possible to shed light on the pathophysiological mechanisms of neuro-urological disorders, allowing us to assess and validate new therapeutic approaches and finally to develop a new method and device for chronic pudendal nerve stimulation.

  5. Neurostimulation for primary headache disorders, part 1: pathophysiology and anatomy, history of neuromodulation in headache treatment, and review of peripheral neuromodulation in primary headaches.

    PubMed

    Jenkins, Brian; Tepper, Stewart J

    2011-09-01

    Neurostimulation for primary headaches is being increasingly utilized as a treatment modality. Use of neuromoduation has generated multiple case reports as well as some controlled studies. This article is the first of 2 systematic reviews of available data regarding neurostimulation for primary headache conditions. The pathophysiology, relative anatomy, theoretical mechanisms, and history of neurostimulation for primary headache are covered in this section, Part 1 of 2. The literature regarding peripheral neurostimulatory targets is also reviewed in Part 1. These peripheral targets include: percutaneous nerves, transcranial holocephalic, occipital nerves, auriculotemporal nerves, supraorbital nerves, cervical epidural, and sphenopalatine ganglia. Part 2 will focus on central stimulation, covering vagus nerve, and deep brain stimulation. Part 2 also contains an overall analysis of efficacy, safety, cost, patient selection, and suggestions for further study based on available evidence.

  6. [Infertility over forty: Pros and cons of IVF].

    PubMed

    Belaisch-Allart, J; Maget, V; Mayenga, J-M; Grefenstette, I; Chouraqui, A; Belaid, Y; Kulski, O

    2015-09-01

    The population attempting pregnancy and having babies is ageing. The declining fertility potential and the late age of motherhood are increasing significantly the number of patients over forty consulting infertility specialists. Assisted reproductive technologies (ART) cannot compensate the natural decline in fertility with age. In France, in public hospital, ART is free of charge for women until 43 years, over 43, social insurance does not reimburse ART. Hence, 43 years is the usual limit, but between 40 and 42 is ART useful? The answer varies according to physicians, couples or society. On medical level, the etiology of the infertility must be taken into account. If there is an explanation to infertility (male or tubal infertility) ART is better than abstention. If the infertility is only due to age the question is raised. In France, the reimbursement by the society of a technique with very low results is discussed. However efficacy is not absolutely compulsory in Medicine. On the opposite to give false hopes may be discussed too. To obtain a reasonable consensus is rather difficult.

  7. Platinum nanowire microelectrode arrays for neurostimulation applications: Fabrication, characterization, and in-vitro retinal cell stimulation

    NASA Astrophysics Data System (ADS)

    Whalen, John J., III

    Implantable electrical neurostimulating devices are being developed for a number of applications, including artificial vision through retinal stimulation. The epiretinal prosthesis will use a two-dimensional array microelectrodes to address individual cells of the retina. MEMS fabrication processes can produce arrays of microelectrodes with these dimensions, but there are two critical issues that they cannot satisfy. One, the stimulating electrodes are the only part of the implanted electrical device that penetrate through the water impermeable package, and must do so without sacrificing hermeticity. Two, As electrode size decreases, the current density (A cm-2 ) increases, due to increased electrochemical impedance. This reduces the amount of charge that can be safely injected into the tissue. To date, MEMS processing method, cannot produce electrode arrays with good, prolonged hermetic properties. Similarly, MEMS approaches do not account for the increased impedance caused by decreased surface area. For these reasons there is a strong motivation for the development of a water-impermeable, substrate-penetrating electrode array with low electrochemical impedance. This thesis presents a stimulating electrode array fabricated from platinum nanowires using a modified electrochemical template synthesis approach. Nanowires are electrochemically deposited from ammonium hexachloroplatinate solution into lithographically patterned nanoporous anodic alumina templates to produce microarrays of platinum nanowires. The platinum nanowires penetrating through the ceramic aluminum oxide template serve as parallel electrical conduits through the water impermeable, electrically insulating substrate. Electrode impedance can be adjusted by either controlling the nanowire hydrous platinum oxide content or by partially etching the alumina template to expose additional surface area. A stepwise approach to this project was taken. First, the electrochemistry of ammonium

  8. Natural Marine and Synthetic Xenobiotics Get on Nematode’s Nerves: Neuro-Stimulating and Neurotoxic Findings in Caenorhabditis elegans

    PubMed Central

    Lieke, Thora; Steinberg, Christian E. W.; Ju, Jingjuan; Saul, Nadine

    2015-01-01

    Marine algae release a plethora of organic halogenated compounds, many of them with unknown ecological impact if environmentally realistic concentrations are applied. One major compound is dibromoacetic acid (DBAA) which was tested for neurotoxicity in the invertebrate model organism Caenorhabditis elegans (C. elegans). This natural compound was compared with the widespread synthetic xenobiotic tetrabromobisphenol-A (TBBP-A) found in marine sediments and mussels. We found a neuro-stimulating effect for DBAA; this is contradictory to existing toxicological reports of mammals that applied comparatively high dosages. For TBBP-A, we found a hormetic concentration-effect relationship. As chemicals rarely occur isolated in the environment, a combination of both organobromines was also examined. Surprisingly, the presence of DBAA increased the toxicity of TBBP-A. Our results demonstrated that organohalogens have the potential to affect single organisms especially by altering the neurological processes, even with promoting effects on exposed organisms. PMID:25955755

  9. Toward a comprehensive hybrid physical-virtual reality simulator of peripheral anesthesia with ultrasound and neurostimulator guidance.

    PubMed

    Samosky, Joseph T; Allen, Pete; Boronyak, Steve; Branstetter, Barton; Hein, Steven; Juhas, Mark; Nelson, Douglas A; Orebaugh, Steven; Pinto, Rohan; Smelko, Adam; Thompson, Mitch; Weaver, Robert A

    2011-01-01

    We are developing a simulator of peripheral nerve block utilizing a mixed-reality approach: the combination of a physical model, an MRI-derived virtual model, mechatronics and spatial tracking. Our design uses tangible (physical) interfaces to simulate surface anatomy, haptic feedback during needle insertion, mechatronic display of muscle twitch corresponding to the specific nerve stimulated, and visual and haptic feedback for the injection syringe. The twitch response is calculated incorporating the sensed output of a real neurostimulator. The virtual model is isomorphic with the physical model and is derived from segmented MRI data. This model provides the subsurface anatomy and, combined with electromagnetic tracking of a sham ultrasound probe and a standard nerve block needle, supports simulated ultrasound display and measurement of needle location and proximity to nerves and vessels. The needle tracking and virtual model also support objective performance metrics of needle targeting technique.

  10. "Forty Acres and a Mule" as a Pedagogical Motif

    ERIC Educational Resources Information Center

    Burch, Kerry

    2008-01-01

    This essay revisits an iconic yet now languishing phrase in United States political culture--"Forty Acres and a Mule"--to clarify the meaning of freedom and to assess the contemporary meaning of its betrayal by the U.S. government immediately after the Civil War. Among the few citizens for whom the phrase still retains a semblance of…

  11. Forty-seventh annual power distribution conference, 1994

    SciTech Connect

    Not Available

    1994-01-01

    This is a collection of papers presented at the forty-seventh annual Power Distribution Conference in 1994. The topics of the papers include recent developments in distribution grounding, partial discharge analysis of electrical machinery, insulating fluids analysis as a basis for a complete transformer monitoring program, environmental and regulatory issues regarding the use of silicone transformer fluids, locating and identifying harmonic sources, optimizing distribution operations resources, surface launch directional boring units, electrical supply to Dallas/Fort Worth international airport, a microprocessor-based digital feeder monitor with high-impedance fault detection, a modern review of distribution system protective coordination, and Ski Apache electric service improvements.

  12. Motor Cortex Neurostimulation Technologies for Chronic Post-stroke Pain: Implications of Tissue Damage on Stimulation Currents.

    PubMed

    O'Brien, Anthony T; Amorim, Rivadavio; Rushmore, R Jarrett; Eden, Uri; Afifi, Linda; Dipietro, Laura; Wagner, Timothy; Valero-Cabré, Antoni

    2016-01-01

    Background: Central post stroke pain (CPSP) is a highly refractory syndrome that can occur after stroke. Primary motor cortex (M1) brain stimulation using epidural brain stimulation (EBS), transcranial magnetic stimulation (TMS), and transcranial direct current stimulation (tDCS) have been explored as potential therapies for CPSP. These techniques have demonstrated variable clinical efficacy. It is hypothesized that changes in the stimulating currents that are caused by stroke-induced changes in brain tissue conductivity limit the efficacy of these techniques. Methods: We generated MRI-guided finite element models of the current density distributions in the human head and brain with and without chronic focal cortical infarctions during EBS, TMS, and tDCS. We studied the change in the stimulating current density distributions' magnitude, orientation, and maxima locations between the different models. Results: Changes in electrical properties at stroke boundaries altered the distribution of stimulation currents in magnitude, location, and orientation. Current density magnitude alterations were larger for the non-invasive techniques (i.e., tDCS and TMS) than for EBS. Nonetheless, the lesion also altered currents during EBS. The spatial shift of peak current density, relative to the size of the stimulation source, was largest for EBS. Conclusion: In order to maximize therapeutic efficiency, neurostimulation trials need to account for the impact of anatomically disrupted neural tissues on the location, orientation, and magnitude of exogenously applied currents. The relative current-neuronal structure should be considered when planning stimulation treatment, especially across techniques (e.g., using TMS to predict EBS response). We postulate that the effects of altered tissue properties in stroke regions may impact stimulation induced analgesic effects and/or lead to highly variable outcomes during brain stimulation treatments in CPSP.

  13. Elevated Hippocampal Cholinergic Neurostimulating Peptide Precursor Protein (HCNP-pp) mRNA in the amygdala in major depression

    PubMed Central

    Bassi, Sabrina; Seney, Marianne L.; Argibay, Pablo; Sibille, Etienne

    2015-01-01

    The amygdala is innervated by the cholinergic system and is involved in major depressive disorder (MDD). Evidence suggests a hyper-activate cholinergic system in MDD. Hippocampal Cholinergic Neurostimulating Peptide (HCNP) regulates acetylcholine synthesis. The aim of the present work was to investigate expression levels of HCNP-precursor protein (HCNP-pp) mRNA and other cholinergic-related genes in the postmortem amygdala of MDD patients and matched controls (females: N=16 pairs; males: N=12 pairs), and in the mouse unpredictable chronic mild stress (UCMS) model that induced elevated anxiety-/depressive-like behaviors (females: N=6 pairs; males: N=6 pairs). Results indicate an up-regulation of HCNP-pp mRNA in the amygdala of women with MDD (p<0.0001), but not males, and of UCMS-exposed mice (males and females; p=0.037). HCNP-pp protein levels were investigated in the human female cohort, but no difference was found. There were no differences in gene expression of acetylcholinesterase (AChE), muscarinic (mAChRs) or nicotinic receptors (nAChRs) between MDD subjects and controls or UCMS and control mice, except for an up-regulation of AChE in UCMS-exposed mice (males and females; p=0.044). Exploratory analyses revealed a baseline expression difference of cholinergic signaling-related genes between women and men (p<0.0001). In conclusion, elevated amygdala HCNP-pp expression may contribute to mechanisms of MDD in women, potentially independently from regulating the cholinergic system. The differential expression of genes between women and men could also contribute to the increased vulnerability of females to develop MDD. PMID:25819500

  14. Motor Cortex Neurostimulation Technologies for Chronic Post-stroke Pain: Implications of Tissue Damage on Stimulation Currents

    PubMed Central

    O’Brien, Anthony T.; Amorim, Rivadavio; Rushmore, R. Jarrett; Eden, Uri; Afifi, Linda; Dipietro, Laura; Wagner, Timothy; Valero-Cabré, Antoni

    2016-01-01

    Background: Central post stroke pain (CPSP) is a highly refractory syndrome that can occur after stroke. Primary motor cortex (M1) brain stimulation using epidural brain stimulation (EBS), transcranial magnetic stimulation (TMS), and transcranial direct current stimulation (tDCS) have been explored as potential therapies for CPSP. These techniques have demonstrated variable clinical efficacy. It is hypothesized that changes in the stimulating currents that are caused by stroke-induced changes in brain tissue conductivity limit the efficacy of these techniques. Methods: We generated MRI-guided finite element models of the current density distributions in the human head and brain with and without chronic focal cortical infarctions during EBS, TMS, and tDCS. We studied the change in the stimulating current density distributions’ magnitude, orientation, and maxima locations between the different models. Results: Changes in electrical properties at stroke boundaries altered the distribution of stimulation currents in magnitude, location, and orientation. Current density magnitude alterations were larger for the non-invasive techniques (i.e., tDCS and TMS) than for EBS. Nonetheless, the lesion also altered currents during EBS. The spatial shift of peak current density, relative to the size of the stimulation source, was largest for EBS. Conclusion: In order to maximize therapeutic efficiency, neurostimulation trials need to account for the impact of anatomically disrupted neural tissues on the location, orientation, and magnitude of exogenously applied currents. The relative current-neuronal structure should be considered when planning stimulation treatment, especially across techniques (e.g., using TMS to predict EBS response). We postulate that the effects of altered tissue properties in stroke regions may impact stimulation induced analgesic effects and/or lead to highly variable outcomes during brain stimulation treatments in CPSP. PMID:27881958

  15. [A woman in her forties with cancer, syncope and spasms].

    PubMed

    Warsame, Mahad Omar; Gamboa, Danil; Nielsen, Erik Waage

    2014-10-14

    A female in her forties with advanced incurable rectal cancer presented to our emergency department after loss of consciousness followed by brief myoclonic jerks in her legs. A cerebral MRI was normal. Her electrocardiogram showed a prolonged QTc interval of 596 milliseconds and hypokalemia was present. She had no family history of congenital long QT syndrome or of cardiovascular disease. She was not on any medication apart from having ingested 100 g caesium carbonate over the previous 11 days as an alternative cancer treatment. Caesium chloride is postulated to increase pH and thereby induce apoptosis in cancer cells. In treatment doses caesium competes with potassium for membrane transport proteins in the cardiac cell membrane and in the reabsorption tubuli of the kidneys. A result is hypokalemia shortly after depolarization during the cardiomyocytes' repolarisation phase or delayed post-depolarisation. Torsade de pointes ventricular arrhythmias, ventricular tachycardia, pump failure and death can follow. A few case reports of adverse effects from caesium ingestion have been published, as well as reports on how caesium is used in animal models to induce ventricular tachycardia, but the hazards of caesium ingestion and its long half-life are not well known in the medical care profession or among patients. As this patient's QTc interval normalised slowly to 413 milliseconds 60 days after stopping caesium ingestion, we consider caesium intoxication and convulsive syncope from a self-terminating ventricular tachycardia as the most probable aetiology. The main message from this case is that alternative medicine can have life-threatening side effects.

  16. Vagus nerve stimulation in drug-resistant epilepsy: the efficacy and adverse effects in a 5-year follow-up study in Iran.

    PubMed

    Pakdaman, Hossein; Amini Harandi, Ali; Abbasi, Mehdi; Karimi, Mohammad; Arami, Mohammad Ali; Mosavi, Seyed Ali; Haddadian, Karim; Rezaei, Omidvar; Sadeghi, Sohrab; Sharifi, Guive; Gharagozli, Koroush; Bahrami, Parviz; Ashrafi, Farzad; Kasmae, Hosein Delavar; Ghassemi, Amirhossein; Arabahmadi, Mehran; Behnam, Behdad

    2016-11-01

    Drug-resistant epilepsy seems like a different disease compared with easy to control epilepsy, and new strategies are needed to help these patients. Vagus nerve stimulation (VNS) therapy is the most frequently used neurostimulation modality for patients with drug-resistant epilepsy who are not eligible for seizure surgery. In this study, we aimed to evaluate the efficacy and adverse effects of VNS in patients with drug-resistant epilepsy in an open-label, prospective, long-term study in Iran. We selected 48 patients with partial-onset drug-resistant epilepsy. Implantations were performed in the neurosurgery department of Loghman Hospital, Tehran, Iran. Follow-up visits were done on monthly bases for 5 years. Forty-four patients completed the study. Mean age of patients was 24.4 years. Mean years of epilepsy history was 14 years. The mean number of anti-epileptic drugs did not significantly change over five years (p = 0.15). There was no exacerbation of epilepsy; however, one patient discontinued his therapy due to unsatisfactory results. Five patient had more than 50 %, and 26 patients (59 %) had 25-49 % reduction in the frequency of monthly seizures persistently. Overall mean frequency of monthly seizures decreased by 57.8, 59.6, 65, 65.9, and 67 %, in 1st, 2nd, 3rd, 4th, and 5th years of follow-up, respectively. Most common side effects were as follows: hoarseness (25 %) and throat discomfort (10 %). We found VNS as a safe and effective therapy for drug-resistant epilepsy, with an approximate long-term decrease in mean seizure frequency of 57.8-67 %. Thus, VNS is recommended for suitable patients in developing countries.

  17. Forty-nine years in Biomaterials Science: an interview with Buddy Ratner

    PubMed Central

    Ratner, Buddy

    2017-01-01

    Buddy Ratner talks to Francesca Lake, Managing Editor. After receiving his PhD in polymer chemistry from the Polytechnic Institute of Brooklyn (USA) in 1972, Ratner moved to the University of Washington (USA), where he has since become joint professor of bioengineering and chemical engineering and Michael L & Myrna Darland Endowed Chair in Technology Commercialization. Since 1996, he has led the UWEB Research Center for Biomaterials at the University of Washington, originally funded by the National Science Foundation. A pioneer of the biomaterials field, Ratner's research interests include biomaterials, tissue engineering, polymers, biocompatibility and surface analysis of organic materials. A leader in the field, he has received numerous awards, has launched several companies and holds over 20 patents. PMID:28344823

  18. Forty Years in the Union: Incubating, Supporting, and Catalyzing Socially Just Educational Change

    ERIC Educational Resources Information Center

    Rottmann, Cindy

    2012-01-01

    North American teacher unions' positive contributions to educational change have historically flown under the radar of educational policy makers, a situation that has been reified by recent attacks on public sector unions. In this article, I draw on social movement theory and an institutional case study of a self described social justice union to…

  19. Forty Years of Struggle and Still No Right to Inuit Education in Nunavut

    ERIC Educational Resources Information Center

    Rasmussen, Derek

    2011-01-01

    In this article issues related to policy and education in the Canadian Arctic are critically put to question. The focus is on the struggle for Inuit education, language issues, and supporting minority rights, with pragmatic solutions proposed to the problems confronting Nunavut.

  20. Biomedical optics centers: forty years of multidisciplinary clinical translation for improving human health

    NASA Astrophysics Data System (ADS)

    Tromberg, Bruce J.; Anderson, R. Rox; Birngruber, Reginald; Brinkmann, Ralf; Berns, Michael W.; Parrish, John A.; Apiou-Sbirlea, Gabriela

    2016-12-01

    Despite widespread government and public interest, there are significant barriers to translating basic science discoveries into clinical practice. Biophotonics and biomedical optics technologies can be used to overcome many of these hurdles, due, in part, to offering new portable, bedside, and accessible devices. The current JBO special issue highlights promising activities and examples of translational biophotonics from leading laboratories around the world. We identify common essential features of successful clinical translation by examining the origins and activities of three major international academic affiliated centers with beginnings traceable to the mid-late 1970s: The Wellman Center for Photomedicine (Mass General Hospital, USA), the Beckman Laser Institute and Medical Clinic (University of California, Irvine, USA), and the Medical Laser Center Lübeck at the University of Lübeck, Germany. Major factors driving the success of these programs include visionary founders and leadership, multidisciplinary research and training activities in light-based therapies and diagnostics, diverse funding portfolios, and a thriving entrepreneurial culture that tolerates risk. We provide a brief review of how these three programs emerged and highlight critical phases and lessons learned. Based on these observations, we identify pathways for encouraging the growth and formation of similar programs in order to more rapidly and effectively expand the impact of biophotonics and biomedical optics on human health.

  1. Nocturnal re-experiencing more than forty years after war trauma.

    PubMed

    Schreuder, B J; Kleijn, W C; Rooijmans, H G

    2000-07-01

    The aim of this study was the examination of Posttraumatic Nightmares (PTNM) and Posttraumatic Anxiety Dreams (PTAD) in Dutch combat veterans and World War II victims. Participants (outpatients; n = 223) were administered a standardized psychiatric interview, the Impact of Event Scale, the SCL-90, the Clinician Administered PTSD Scale, and an interview on posttraumatic nocturnal re-experiencing. Prevalence of PTNM was 56%. Patients with PTNM, even those who were not diagnosed with PTSD, had significantly more psychiatric complaints than patients with no PTNM. Analysis of PTNM demonstrated that they were often experienced as exact replications of the original traumatic events. Replicative PTNM often implicated dream recurrence. Traumatic experiences before the age of 5 resulted in nonreplicative PTNM only. Unlike nonreplicative PTNM, replicative PTNM seemed to be correlated with several intrusion subscales.

  2. Forty-nine years in Biomaterials Science: an interview with Buddy Ratner.

    PubMed

    Ratner, Buddy

    2017-03-01

    Buddy Ratner talks to Francesca Lake, Managing Editor. After receiving his PhD in polymer chemistry from the Polytechnic Institute of Brooklyn (USA) in 1972, Ratner moved to the University of Washington (USA), where he has since become joint professor of bioengineering and chemical engineering and Michael L & Myrna Darland Endowed Chair in Technology Commercialization. Since 1996, he has led the UWEB Research Center for Biomaterials at the University of Washington, originally funded by the National Science Foundation. A pioneer of the biomaterials field, Ratner's research interests include biomaterials, tissue engineering, polymers, biocompatibility and surface analysis of organic materials. A leader in the field, he has received numerous awards, has launched several companies and holds over 20 patents.

  3. Forty Years of Research on Xeroderma Pigmentosum at the US National Institutes of Health†

    PubMed Central

    Kraemer, Kenneth H.; DiGiovanna, John J.

    2014-01-01

    In 1968, Dr. James Cleaver reported defective DNA repair in cultured cells from patients with xeroderma pigmentosum. This link between clinical disease and molecular pathophysiology has sparked interest in understanding not only the clinical characteristics of sun sensitivity, damage and cancer that occurred in XP patients but also the mechanisms underlying the damage and repair. While affected patients are rare, their exaggerated UV damage provides a window into the workings of DNA repair. These studies have clarified the importance of a functioning DNA repair system to the maintenance of skin and neurologic health in the general population. Understanding the role of damage in causing cancer, neurologic degeneration, hearing loss and internal cancers provides an opportunity for prevention and treatment. Characterizing complementation groups pointed to the importance of different underlying genes. Studying differences in cancer age of onset and underlying molecular signatures in cancers occurring either in XP patients or the general population has led to insights into differences in carcinogenic mechanisms. The accelerated development of cancers in XP has been used as a model to discover new cancer chemopreventive agents. An astute insight can be a “tipping point” triggering decades of productive inquiry. PMID:25220021

  4. Forty years of research on xeroderma pigmentosum at the US National Institutes of Health.

    PubMed

    Kraemer, Kenneth H; DiGiovanna, John J

    2015-01-01

    In 1968, Dr. James Cleaver reported defective DNA repair in cultured cells from patients with xeroderma pigmentosum. This link between clinical disease and molecular pathophysiology has sparked interest in understanding not only the clinical characteristics of sun sensitivity, damage and cancer that occurred in XP patients but also the mechanisms underlying the damage and repair. While affected patients are rare, their exaggerated UV damage provides a window into the workings of DNA repair. These studies have clarified the importance of a functioning DNA repair system to the maintenance of skin and neurologic health in the general population. Understanding the role of damage in causing cancer, neurologic degeneration, hearing loss and internal cancers provides an opportunity for prevention and treatment. Characterizing complementation groups pointed to the importance of different underlying genes. Studying differences in cancer age of onset and underlying molecular signatures in cancers occurring either in XP patients or the general population has led to insights into differences in carcinogenic mechanisms. The accelerated development of cancers in XP has been used as a model to discover new cancer chemopreventive agents. An astute insight can be a "tipping point" triggering decades of productive inquiry.

  5. Forty-Five Years After Broadbent (1958): Still No Identification Without Attention

    ERIC Educational Resources Information Center

    Lachter, Joel; Forster, Kenneth I.; Ruthruff, Eric

    2004-01-01

    According to D. E. Broadbent's (1958) selective filter theory, people do not process unattended stimuli beyond the analysis of basic physical properties. This theory was later rejected on the basis of numerous findings that people identify irrelevant (and supposedly unattended) stimuli. A careful review of this evidence, however, reveals strong…

  6. Forty-Five Years of Frustration: America’s Enduring Dilemma of Fighting Insurgents with Airpower

    DTIC Science & Technology

    2011-01-01

    insurgents, known by their moniker “Vietcong” or “VC,” received manpower and material support from their North Vietnam- ese partners to help overthrow...war, an estimated 2.9 million were Roman Catholics. The remainder subscribed to a blend of Buddhism, animism, and astrology ; Confu- cian principles

  7. Forty years of improvements in European air quality: the role of EU policy-industry interplay

    NASA Astrophysics Data System (ADS)

    Crippa, M.; Janssens-Maenhout, G.; Dentener, F.; Guizzardi, D.; Sindelarova, K.; Muntean, M.; Van Dingenen, R.; Granier, C.

    2015-07-01

    The EDGAR (Emissions Database for Global Atmospheric Research) v4.3 global anthropogenic emissions inventory of several gaseous (SO2, NOx, CO, non-methane volatile organic compounds (NMVOCs) and NH3) and particulate (PM10, PM2.5, black and organic carbon (BC and OC)) air pollutants for the period 1970-2010 is used to develop retrospective air pollution emission scenarios to quantify the roles and contributions of changes in fuels consumption, technology, end-of-pipe emission reduction measures and their resulting impact on health and crop yields. This database presents changes in activity data, fuels and air pollution abatement technology for the past 4 decades, using international statistics and following guidelines for bottom-up emission inventory at the Tier 1 and Tier 2 levels with region-specific default values. With two further retrospective scenarios we assess (1) the impact of the technology and end-of-pipe (EOP) reduction measures in the European Union (EU) by considering a stagnation of technology with constant emission factors from 1970 and with no further abatement measures and improvement in European emissions standards, but fuel consumption occurring at historical pace, and (2) the impact of increased fuel consumption by considering unchanged energy use with constant fuel consumption since 1970, but technological development and end-of-pipe reductions. Our scenario analysis focuses on the three most important and most regulated sectors (power generation, the manufacturing industry and road transport), which are subject of multi-pollutant EU Air Quality regulations. If technology and European EOP reduction measures had stagnated at 1970 levels, EU air quality in 2010 would have suffered from 129 % higher SO2, 71 % higher NOx and 69 % higher PM2.5 emissions, demonstrating the large role of technology in reducing emissions in 2010. However, if fuel consumption had remained constant starting in 1970, the EU would have benefited from current technology and emission control standards, with reductions in NOx by even 13 % more. Such further savings are not observed for SO2 and PM2.5. If the EU consumed the same amount of fuels as in 1970 but with the current technology and emission control standards, then the emissions of SO2 and PM2.5 would be 42 % respectively 10 % higher. This scenario shows the importance for air quality of abandoning heavy residual fuel oil and shifting fuel types (from, e.g., coal to gas) in the EU. A reduced-form TM5-FASST (Fast Screening Scenario Tool based on the global chemical Transport Model 5) is applied to calculate regional and global levels of aerosol and ozone concentrations and to assess the impact of air quality improvements on human health and crop yield loss, showing substantial impacts of export of EU technologies and standards to other world regions.

  8. Forty Years of Progress: Where Have We Been? Where Are We Now?

    ERIC Educational Resources Information Center

    Black, Rhonda S.; Salas, Beverly A.

    This paper uses personal profiles to highlight major events across the past five decades that have affected the lives of individuals with mental retardation and their families. Each of the scenarios provided represents a creation of prototypical families, communities, school climates, issues, and social attitudes during a particular decade.…

  9. Change and Continuity in Modern Japanese Educational History: Allied Occupational Reforms Forty Years Later.

    ERIC Educational Resources Information Center

    Wray, Harry

    1991-01-01

    Describes the efforts of post-World War II U.S. occupiers to change radically the structure, philosophies, content, and teaching methods of Japanese elementary, secondary, and higher education. Compares prewar and current conditions. Discusses cultural and political reasons why these efforts to transplant foreign institutions and values largely…

  10. Forty years on: Uta Frith's contribution to research on autism and dyslexia, 1966–2006

    PubMed Central

    Bishop, Dorothy V. M.

    2008-01-01

    Uta Frith has made a major contribution to our understanding of developmental disorders, especially autism and dyslexia. She has studied the cognitive and neurobiological bases of both disorders and demonstrated distinctive impairments in social cognition and central coherence in autism, and in phonological processing in dyslexia. In this enterprise she has encouraged psychologists to work in a theoretical framework that distinguishes between observed behaviour and the underlying cognitive and neurobiological processes that mediate that behaviour. PMID:18038335

  11. Forty years of litigation involving residents and their training: II. Malpractice issues.

    PubMed

    Helms, L B; Helms, C M

    1991-12-01

    The authors reviewed 136 cases of malpractice litigation involving residents or programs of graduate medical education that were reported from 1950 through 1989. Before 1970 malpractice constituted the only area of reported litigation for residents. The number of malpractice cases involving residents increased substantially after 1975, paralleling the growth of malpractice cases nationally. The regional pattern of reported cases involving residents also corresponded with previous findings. Questions of vicarious liability, the applicable standard of care, and residents' supervision were at issue in the great majority of cases. Questions related to judicial procedure, immunity from liability, breach or causation, and informed consent were also litigated. Residents were on the side of the prevailing party in 44% of the cases. Malpractice continues to be the key legal issue facing programs of residency training.

  12. Evolution of Technology for Continuous Renal Replacement Therapy: Forty Years of Improvements.

    PubMed

    Ronco, Claudio

    2017-01-01

    Continuous arteriovenous hemofiltration (CAVH) was proposed in 1977 as an alternative treatment for acute renal failure in patients in whom peritoneal dialysis or hemodialysis was clinically or technically precluded. In the mid-1980s, this technique was extended to infants and children. CAVH presented important advantages in the areas of hemodynamic stability, control of circulating volume, and nutritional support. However, there were serious shortcomings such as the need for arterial cannulation and limited solute clearance. These problems were solved by the introduction of continuous arteriovenous hemodiafiltration (CAVHDF) and continuous arteriovenous hemodialysis (CAVHD) where uremic control could be by increasing countercurrent dialysate flow rates to 1.5 or 2 liters/h as necessary, or by venovenous techniques utilizing a double-lumen central venous catheter for vascular access. Thus, continuous venovenous hemofiltration replaced CAVH because of its improved performance and safety. From the initial adoptive technology, specific machines have been designed to permit safe and reliable performance of the therapy. These new machines have progressively undergone a series of technological steps that have resulted in the highly sophisticated equipment utilized today. A significant number of advances have taken place since the beginning of continuous renal replacement therapy. In particular, there have been successful experiments with high-volume hemofiltration and high-permeability hemofiltration. The additional and combined use of sorbent has also been tested successfully. Progress has been made in the technology as well as the understanding of the pathophysiology of acute kidney injury. Today, new biomaterials and new devices are available and new frontiers are on the horizon. Although improvements have been made, a lot remains to be done. Critical care nephrology is expected to further evolve in the near future, especially in the area of information and communication technology, utilization of big data and large database registries, biofeedback, and assisted prescription and treatment delivery, with high potential for improvement in morbidity and mortality of the most severely ill patients.

  13. Forty Years of Research and Development at Griffiss Air Force Base, June 1951-June 1991

    DTIC Science & Technology

    1991-06-01

    Broadband Tee Sections Sperry Gyroscope Co. developed and constructed tees for all standard waveguide sizes for the frequency range 2600 to 40,000...Co. for rework, since it did not conform to Air Force specifications. Broadband Transmission Line Adapters RADC accepted delivery of two waveguide-to...type "N" adapters from Microwave Development Laboratory. The broadband transmission line adapter series developed under this program would cover the

  14. Forty-Two Ethiopian Boys: Observations of Their First Year in Israel.

    ERIC Educational Resources Information Center

    Zima, Suellen

    1987-01-01

    Provides observations by a social worker functioning as a housemother to Ethiopian Jewish refugee adolescent boys recently arrived in Israel. Discusses boys' technologicial and cultural adjustment, health and mental health problems, and racial problems. (ABL)

  15. Forty years of change: a northern Alaskan seabird's response to a warming Arctic

    NASA Astrophysics Data System (ADS)

    Divoky, G.; Suydam, R.

    2012-12-01

    While recent decadal-scale decreases in the snow and ice habitats of the Arctic are well documented, there are few concurrent long-term biological data sets, especially for species dependent on the cryopelagic ecosystem associated with arctic sea ice. The Black Guillemot (Cepphus grylle mandti), a marine apex predator specializing on prey associated with arctic pack ice has been studied annually since 1975 at a colony on Cooper Island, 35 km east of Point Barrow, Alaska. Over the last four decades critical components of the species' life history have been found to be sensitive to a number of physical and biological effects associated with the region's increasing atmospheric temperatures. Black Guillemots first colonized northern Alaska in the late 1960s and early 1970s as the annual snow-free period increased sufficiently to allow access to nesting cavities for the 80 days required to successfully raise young. At the Cooper Island colony abundance increased during the 1970s and 1980s as summer length continued to increase and wooden nest cavities were provided to increase sample size for monitoring. During this time breeding success was high as summer sea ice remained in the 30-km foraging range of guillemot parents, providing Arctic Cod (Boreogadus saida), the principal forage fish associated with sea ice and the preferred prey of Black Guillemots. Decreasing summer sea ice extent in the 1990s that accelerated in the last decade reduced the guillemots' access to cryopelagic prey during the critical period when parents are provisioning nestlings. Distance from the colony to the pack ice on 15 August averaged <25 km from 1975-2002 but increased to an average of >100 km from 2003-2011. This ice retreat had a major affect on Arctic Cod availability, causing parent guillemots to shift to lower quality benthic fish resulting in decreases in nestling quality and breeding success when sea ice had retreated and SST was > 4o C. Increasing loss of summer ice in the last decade also facilitated changes in the distribution of a guillemot nest competitor and nest predator resulting in major losses of eggs and young. Horned Puffins (Fratercula corniculata) recently expanded their breeding range from the subarctic to northern Alaska and regularly disrupt guillemot nesting by displacing eggs and killing guillemot nestlings while prospecting for nest sites. Polar Bears (Ursus maritimus), rare on Cooper Island until 2002 are now seen regularly in August as they seek refuge on land and prey on guillemot young. While the loss of cryopelagic prey led to reductions in the guillemot population, the loss of eggs and nestlings to puffins and bears was severe enough to threaten the existence of the colony. In 2011 all nest sites at the colony were replaced with plastic nest cases that eliminate disturbance by bears and puffins. Upper trophic level predators are recognized as important indicators of variation in and perturbations to marine ecosystems and in the near future the waters of the western Arctic will be experiencing a range of alterations due to both atmospheric warming and industrial development. The ongoing research at the Cooper Island Black Guillemot colony, combined with its historic database. will allow assessment of those changes.

  16. Forty Years On: Norbert Elias and the Young Worker Project. CLMS Working Paper.

    ERIC Educational Resources Information Center

    Goodwin, John; O'Connor, Henrietta

    A study performed in 1962 by Norbert Elias on the adjustment of young people to the transition from school to work had five areas of inquiry; adjustment to relationships with older workers and supervisors; adjustment to job problems; adjustment to role as workers; adjustment to role as money-earner in home relations; and adjustment to role as…

  17. Forty five years with membrane phospholipids, phospholipases and lipid mediators: A historical perspective.

    PubMed

    Chap, Hugues

    2016-06-01

    Phospholipases play a key role in the metabolism of phospholipids and in cell signaling. They are also a very useful tool to explore phospholipid structure and metabolism as well as membrane organization. They are at the center of this review, covering a period starting in 1971 and focused on a number of subjects in which my colleagues and I have been involved. Those include determination of phospholipid asymmetry in the blood platelet membrane, biosynthesis of lysophosphatidic acid, biochemistry of platelet-activating factor, first attempts to define the role of phosphoinositides in cell signaling, and identification of novel digestive (phospho)lipases such as pancreatic lipase-related protein 2 (PLRP2) or phospholipase B. Besides recalling some of our contributions to those various fields, this review makes an appraisal of the impressive and often unexpected evolution of those various aspects of membrane phospholipids and lipid mediators. It is also the occasion to propose some new working hypotheses.

  18. Forty Years of Litigation Involving Residents and Their Training: II. Malpractice Issues.

    ERIC Educational Resources Information Center

    Helms, Lelia B.; Helms, Charles M.

    1991-01-01

    A review of 136 malpractice cases involving residents and resident programs 1950-83 found a substantial increase in cases after 1975. Most concerned vicarious liability, applicable standard of care, and resident supervision. Residents were on the side of the prevailing party in 44 percent of cases. (Author/MSE)

  19. Forty years after the first dark resonance experiment: an overview of the COSMA project results

    NASA Astrophysics Data System (ADS)

    Mariotti, E.; Bevilacqua, G.; Biancalana, V.; Cecchi, R.; Dancheva, Y.; Khanbekyan, Alen; Marinelli, C.; Moi, L.; Stiaccini, L.; Cartaleva, S.; Andreeva, C.; Alipieva, E.; Gateva, S.; Krasteva, A.; Slavov, D.; Taskova, E. T.; Taslakov, M.; Todorov, P.; Tsvetkov, S.; Wilson Gordon, A.; Margalit, L.; Gawlik, W.; Pustelny, S.; Stabrawa, A.; Sudyka, J.; Wojciechowski, A.; Renzoni, F.; Deans, C.; Hussain, S.; Marmugi, L.; Rassi, D.; Ozun, O.; Sarkisyan, D.; Azizbekyan, H.; Drampyan, R.; Khanbekyan, Alek.; Mirzoyan, R.; Papoyan, A.; Sargsyan, A.; Shmavonyan, S.; Tonoyan, A.; Ghosh, P. N.; Dey, S.; Mitra, S.; Ray, B.; Nasyrov, K. A.; Chapovsky, P.; Entin, V.; Nikolov, N.; Petrov, N.; Budker, D.; Patton, B.; Wickenbrock, A.; Zhivun, L.; Gozzini, S.

    2016-01-01

    COSMA: Coherent Optics Sensors for Medical Application is an European Marie Curie Project running from 2012 to March 2016, with the participation of 10 teams from Armenia, Bulgaria, India, Israel, Italy, Poland, Russia, UK, USA. The main objective was to focus theoretical and experimental research on biomagnetism phenomena, with the specific aim to develop all-optical sensors dedicated to their detection and suitable for applications in clinical diagnostics. The paper presents some of the most recent results obtained during the exchange visits of the involved scientists, after an introduction about the phenomenon which is the pillar of this kind of research and of many other new fields in laser spectroscopy, atomic physics, and quantum optics: the dark resonance.

  20. Enduring Documents and Public Doctrines: Martin Luther King's "Letter from Birmingham Jail" after Forty Years

    ERIC Educational Resources Information Center

    Aeschliman, M. D.

    2005-01-01

    In the century just past, the immense ethical and political destructiveness of intellectuals was so frequent and protean in form that intellectual historians have a story as complex as it is tragic to tell, and one that many of them do not relish, perhaps out of occupational solidarity or shame. The "treason of the intellectuals," to use…

  1. Forty years experience in developing and using rainfall simulators under tropical and Mediterranean conditions

    NASA Astrophysics Data System (ADS)

    Pla-Sentís, Ildefonso; Nacci, Silvana

    2010-05-01

    Rainfall simulation has been used as a practical tool for evaluating the interaction of falling water drops on the soil surface, to measure both stability of soil aggregates to drop impact and water infiltration rates. In both cases it is tried to simulate the effects of natural rainfall, which usually occurs at very different, variable and erratic rates and intensities. One of the main arguments against the use of rainfall simulators is the difficulty to reproduce the size, final velocity and kinetic energy of the drops in natural rainfall. Since the early 70´s we have been developing and using different kinds of rainfall simulators, both at laboratory and field levels, and under tropical and Mediterranean soil and climate conditions, in flat and sloping lands. They have been mainly used to evaluate the relative effects of different land use and management, including different cropping systems, tillage practices, surface soil conditioning, surface covers, etc. on soil water infiltration, on runoff and on erosion. Our experience is that in any case it is impossible to reproduce the variable size distribution and terminal velocity of raindrops, and the variable changes in intensity of natural storms, under a particular climate condition. In spite of this, with the use of rainfall simulators it is possible to obtain very good information, which if it is properly interpreted in relation to each particular condition (land and crop management, rainfall characteristics, measurement conditions, etc.) may be used as one of the parameters for deducing and modelling soil water balance and soil moisture regime under different land use and management and variable climate conditions. Due to the possibility for a better control of the intensity of simulated rainfall and of the size of water drops, and the possibility to make more repeated measurements under very variable soil and land conditions, both in the laboratory and specially in the field, the better results have been obtained with small size 500-1000 cm2, easily dismantled, drop former simulators, than with larger, nozzle, or more sophisticated equipments. In this contribution there are presented some of the rainfall simulators developed and used by the main author, and some of the results obtained in different studies of practical problems under tropical and Mediterranean conditions. References Pla, I.,G.Campero, y R.Useche.1974.Physical degradación of agricultural soils in the Western Plains of Venezuela. "Trans.10th Int.Cong.Soil.Sci.Soc". 1:231-240. .Moscú Pla, I. 1975.Effects of bitumen emulsion and polyacrilamide on some physical properties of Venezuelan soils. En "Soil Sci. Soc. Am. Special Publication"• 7. 35-46. Madison. Wisconsin . (USA). Pla, I. 1977.Aggregate size and erosion control on sloping land treated with hydrophobic bitumen emulsion."Soil Conservation and Management in the Humid Tropics".109-115. John Wiley & Sons. Pla, I.1981.Simuladores de lluvia para el estudio de relaciones suelo-agua bajo agricultura de secano en los trópicos. Rev. Fac. Agron. XII(1-2):81-93.Maracay (Venezuela) Pla, I. 1986.A routine laboratory index to predict the effects of soil sealing on soil and water conservation. En "Assesment of Soil Surface Sealing and Crusting". 154-162.State Univ. of Ghent.Gante (Bélgica Pla, I., M.C. Ramos, S. Nacci, F. Fonseca y X. Abreu. 2005. Soil moisture regime in dryland vineyards of Catalunya (Spain) as influenced by climate, soil and land management. "Integrated Soil and Water Management for Orchard Development". FAO Land and Water Bulletin 10. 41-49. Roma (Italia).

  2. Forty-five years after Broadbent (1958): still no identification without attention

    NASA Technical Reports Server (NTRS)

    Lachter, Joel; Forster, Kenneth I.; Ruthruff, Eric

    2004-01-01

    According to D. E. Broadbent's (1958) selective filter theory, people do not process unattended stimuli beyond the analysis of basic physical properties. This theory was later rejected on the basis of numerous findings that people identify irrelevant (and supposedly unattended) stimuli. A careful review of this evidence, however, reveals strong reasons to doubt that these irrelevant stimuli were in fact unattended. This review exposed a clear need for new experiments with tight control over the locus of attention. The authors present 5 such experiments using a priming paradigm. When steps were taken to ensure that irrelevant stimuli were not attended, these stimuli produced no priming effects. Hence, the authors found no evidence that unattended stimuli can be identified. The results support a modern version of Broadbent's selective theory, updated to reflect recent research advances. 2004 APA.

  3. Forty Years of the "Journal of Librarianship and Information Science": A Quantitative Analysis, Part I

    ERIC Educational Resources Information Center

    Furner, Jonathan

    2009-01-01

    This paper reports on the first part of a two-part quantitative analysis of volume 1-40 (1969-2008) of the "Journal of Librarianship and Information Science" (formerly the "Journal of Librarianship"). It provides an overview of the current state of LIS research journal publishing in the UK; a review of the publication and…

  4. Thinning of the ice sheet in northwest Greenland over the past forty years.

    PubMed

    Paterson, W S; Reeh, N

    2001-11-01

    Thermal expansion of the oceans, as well as melting of glaciers, ice sheets and ice caps have been the main contributors to global sea level rise over the past century. The greatest uncertainty in predicting future sea level changes lies with our estimates of the mass balance of the ice sheets in Greenland and Antarctica. Satellite measurements have been used to determine changes in these ice sheets on short timescales, demonstrating that surface-elevation changes on timescales of decades or less result mainly from variations in snow accumulation. Here we present direct measurements of the changes in surface elevation between 1954 and 1995 on a traverse across the north Greenland ice sheet. Measurements over a time interval of this length should reflect changes in ice flow-the important quantity for predicting changes in sea level-relatively unperturbed by short-term fluctuations in snow accumulation. We find only small changes in the eastern part of the transect, except for some thickening of the north ice stream. On the west side, however, the thinning rates of the ice sheet are significantly higher and thinning extends to higher elevations than had been anticipated from previous studies.

  5. Education and Geopolitics in a Changing Europe: Forty Years of Scholarship in "European Education"

    ERIC Educational Resources Information Center

    Silova, Iveta; Brehm, William C.

    2009-01-01

    This article chronicles the history of the journal "European Education" since its establishment in 1969 by placing it within the larger context of geopolitical changes of the twentieth century and the historical debates on theory and method in the field of comparative education. Drawing on quantitative and qualitative content analysis of…

  6. [Odón de Buen: forty-five years of commitment to the university].

    PubMed

    Gomis, Alberto

    2011-01-01

    The aragonese naturalist Odón de Buen y del Cos for twenty-two annual academic courses professor of natural history at the University of Barcelona and for twenty-three of the University of Madrid. Strong supporter of Darwin's evolutionary theory, experimental work in the field and laboratory, in this paper puts the value of their efforts, as an educator, to popularize the natural sciences and thus separated from the concerns, superstition and fanaticism, which they were basic reasons of the moral and material backwardness in which Spain was found.

  7. Forty years of USAID health cooperation in Bolivia. A lose-lose game?

    PubMed

    Tejerina, Herland; Closon, Marie-Christine; De Paepe, Pierre; Darras, Christian; Van Dessel, Patrick; Unger, Jean-Pierre

    2014-01-01

    The present article proposes an analysis of the USA-Bolivia relationships in the health sector between 1971 and 2010 based on a grey and scientific literature review and on interviews. We examined United States Agency for International Development (USAID) interventions, objectives, consistency with Bolivian needs, and impact on health system integration. USAID operational objectives--decentralization, fertility and disease control, and maternal and child health--may have worked against each other while competing for limited Ministry of Health resources. They largely contributed to the segmentation and fragmentation of the Bolivian health system. US cooperation in health did not significantly improve health status while the USAID failed to properly tackle anti-drugs, political, and economic US interests in Bolivia.

  8. The Changing Frontiers of Comparative Education: A Forty-Year Retrospective on "European Education"

    ERIC Educational Resources Information Center

    Silova, Iveta

    2009-01-01

    "European Education" (originally known as "Western European Education") may no longer be directly associated with the field of comparative and international education, yet its establishment in 1969 was an attempt to make a direct contribution to the academic debates about the future of comparative education. The journal emerged…

  9. Forty Years and Escalating: Drugs Between the United States and Mexico

    DTIC Science & Technology

    2009-12-16

    of cocaine, 2,730 pounds of methamphetamine , 29 pounds of heroin, 16,390 pounds of marijuana, 389 weapons, 269 vehicles and two clandestine drug labs...drug wars as it battles the trafficking of 90 percent of the cocaine, 80 percent of the marijuana, 80 percent of the methamphetamines and 20-30

  10. From Precaution to Peril: Public Relations Across Forty Years of Genetic Engineering.

    PubMed

    Hogan, Andrew J

    2016-12-01

    The Asilomar conference on genetic engineering in 1975 has long been pointed to by scientists as a model for internal regulation and public engagement. In 2015, the organizers of the International Summit on Human Gene Editing in Washington, DC looked to Asilomar as they sought to address the implications of the new CRISPR gene editing technique. Like at Asilomar, the conveners chose to limit the discussion to a narrow set of potential CRISPR applications, involving inheritable human genome editing. The adoption by scientists in 2015 of an Asilomar-like script for discussing genetic engineering offers historians the opportunity to analyze the adjustments that have been made since 1975, and to identify the blind spots that remain in public engagement. Scientists did take important lessons from the fallout of their limited engagement with public concerns at Asilomar. Nonetheless, the scientific community has continued to overlook some of the longstanding public concerns about genetic engineering, in particular the broad and often covert genetic modification of food products.

  11. Revising the forty-year old paradigm: from Giant Molecular Clouds to Molecular Gas Clusters.

    NASA Astrophysics Data System (ADS)

    Colombo, Dario; Rosolowsky, Erik William; Duarte Cabral, Ana; Ginsburg, Adam; Hughes, Annie; Kalinova Dimitrova, Veselina

    2015-08-01

    Since the first large surveys of early 80s, the statistical description of Giant Molecular Cloud properties has provided important insights into the physics that govern the star formation itself. However, those statistics heavily rely on the performance of automatic identification algorithms that are often seriously affected by the survey design — notably sensitivity and resolution.In this presentation, I will discuss how some of the limitations of commonly used algorithms can be overcome by considering the cloud segmentation problem in the broad framework of the graph theory. Additionally, the clustering analysis provides a natural and robust mathematical description of the molecular ISM discrete features that might be viewed as “Molecular Gas Clusters”.In particular, the algorithm we designed (SCIMES - Spectral Clustering for Molecular Emission Segmentation) applies the spectral clustering approach to look for relevant objects within topological graphs of emission (dendrograms) from star-forming clouds. SCIMES appears especially useful for the cloud identification within complex molecular emission data cubes since, in contrast to other algorithms, it does not over-divide structures, faithfully reproducing the work of the human eyes.To prove this, I will show the cloud decomposition obtained by SCIMES from the CO High Resolution Survey, where the clustering approach allows to automatically identify a variety of gas morphologies including coherent filamentary structures and holes within the molecular ISM. To calculate the cloud physical properties, distances to the clouds are attributed through the dendrograms using data from the BOLOCAM Survey, while the cloud size-line width relation is explored using a Principal Component Analysis approach as well as in the classical way.Finally, I will discuss how SCIMES introduces a new philosophy in the identification of the molecular clouds, where virtually every property of the molecular emission might be used for the ISM segmentation. This may be helpful for distinguishing between the dominant physical mechanisms responsible for the formation of those molecular clusters.

  12. Revising the forty-year old paradigm: from Giant Molecular Clouds to Molecular Gas Clusters

    NASA Astrophysics Data System (ADS)

    Colombo, Dario; Rosolowsky, Erik William; Duarte Cabral, Ana; Ginsburg, Adam; Hughes, Annie; Kalinova Dimitrova, Veselina

    2015-08-01

    Since the first large surveys of early 80s, the statistical description of Giant Molecular Cloud properties has provided important insights into the physics that govern the star formation itself. However, those statistics heavily rely on the performance of automatic identification algorithms that are often seriously affected by the survey design — notably sensitivity and resolution.In this presentation, I will discuss how some of the limitations of commonly used algorithms can be overcome by considering the cloud segmentation problem in the broad framework of the graph theory. Additionally, the clustering analysis provides a natural and robust mathematical description of the molecular ISM discrete features that might be viewed as “Molecular Gas Clusters”.In particular, the algorithm we designed (SCIMES - Spectral Clustering for Molecular Emission Segmentation) applies the spectral clustering approach to look for relevant objects within topological graphs of emission (dendrograms) from star-forming clouds. SCIMES appears especially useful for the cloud identification within complex molecular emission data cubes since, in contrast to other algorithms, it does not over-divide structures, faithfully reproducing the work of the human eyes.To prove this, I will show the cloud decomposition obtained by SCIMES from the CO High Resolution Survey, where the clustering approach allows to automatically identify a variety of gas morphologies including coherent filamentary structures and holes within the molecular ISM. To calculate the cloud physical properties, distances to the clouds are attributed through the dendrograms using data from the BOLOCAM Survey, while the cloud size-line width relation is explored using a Principal Component Analysis approach as well as in the classical way.Finally, I will discuss how SCIMES introduces a new philosophy in the identification of the molecular clouds, where virtually every property of the molecular emission might be used for the ISM segmentation. This may be helpful for distinguishing between the dominant physical mechanisms responsible for the formation of those molecular clusters.

  13. Genome changes due to forty years of artificial selection associated with divergent dairy production and reproduction

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Artificial selection in dairy cattle since 1964 has achieved steady increase in milk production that was accompanied by unintended declines in fertility. Direct comparison of 45,878 SNPs between a group of Holstein cattle unselected since 1964 and the contemporary Holsteins was conducted to identify...

  14. Forty years of litigation involving medical students and their education: II. Issues of finance.

    PubMed

    Helms, L B; Helms, C M

    1991-02-01

    An analysis of reported state and federal adjudication from 1950 through 1989 was undertaken to identify trends in litigation involving medical students and undergraduate medical education. Of the 110 cited judicial decisions during that time, 59 (54%) involved disputes over financing medical education; 43 (73%) were litigated since 1985. This dramatic increase arises primarily from challenges to National Health Service Corps obligations and from attempts to discharge or reorganize debt under the Bankruptcy Code. Medical school graduates enjoyed very little success in these cases. Analysis of court decisions points to a need for informed counseling for medical students, particularly as to the consequences of timing in default on service obligations and of incurring loans under the Health Education Assistance Loan (HEAL) program as opposed to other loan sources. The growing educational debt of today's medical students foreshadows continued litigation in this area.

  15. Feline Leprosy: A Review of Forty-four Cases from Western Canada

    PubMed Central

    McIntosh, D.W.

    1982-01-01

    Forty-four files of cats diagnosed as having feline leprosy were reviewed. All except one were from along the Pacific coast in the Province of British Columbia. The majority of cats were between one and three years of age and there was an increase in the number of diagnosis during the winter months. Two types of granulomatous responses similar to the tuberculoid and lepromatous phases of human leprosy were recognized. In spite of the overall similarities in the cellular response to human leprosy there were, however, significant differences such as areas of caseous necrosis and constant lack of nerve involvement. Still as there is presently no way to prove that Mycobacterium leprae is not the cause of feline leprosy the public health significance remains uncertain The treatment of choice would appear to be surgical removal. ImagesFigure 3.Figure 4.Figure 5. PMID:17422188

  16. 77 FR 54930 - Carlyle Plastics and Resins, Formerly Known as Fortis Plastics, A Subsidiary of Plastics...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-06

    ... Employment and Training Administration Carlyle Plastics and Resins, Formerly Known as Fortis Plastics, A Subsidiary of Plastics Acquisitions Inc., Including On-Site Leased Workers From Kelly Services and Shelley... Adjustment Assistance on July 3, 2012, applicable to workers and former workers of workers of Fortis...

  17. Indoor air quality study of forty east Tennessee homes

    SciTech Connect

    Hawthorne, A.R.; Gammage, R.B.; Dudney, C.S.; Hingerty, B.E.; Schuresko, D.D.; Parzyck, D.C.; Womack, D.R.; Morris, S.A.; Westley, R.R.; White, D.A.

    1984-12-01

    Over a one-year period, measurements of indoor air pollutants (CO/sub x/, NO/sub x/, formaldehyde, volatile organics, particulates, and radon) were made in 40 homes in East Tennessee. The houses were of various ages with different types of insulation and heating. Over one-half of the houses exceeded the ASHRAE indoor ceiling guideline of 0.1 ppM for formaldehyde on at least one occasion. Over the duration of the study, older houses averaged 0.04 ppM of formaldehyde while houses less than 5 years old averaged 0.08 ppM (P < 0.01). The highest concentration of formaldehyde measured was 0.4 ppM in a new home. Diurnal and seasonal fluctuations in levels of formaldehyde in some homes were as much as twofold and tenfold, respectively. The highest levels of formaldehyde were usually recorded during summer months. The concentration in indoor air of various organics was at least tenfold higher than in outdoor air. Carbon monoxide and nitrgen oxides were usually <2 and <0.02 ppM, respectively, except when gas stoves or kerosene space heaters were operating, or when a car was running in the garage. In 30% of the houses, the annual indoor guideline for radon, 4 pCi/L, was exceeded. The mean radon level in houses built on the ridgelines was 4.4 pCi/L, while houses located in the valleys had a mean level of 1.7 pCi/L (P < 0.01). The factor having the most impact on infiltration was operation of the central duct fan of the heating, ventilation, and air conditioning system. The mean rate of air exchange increased from 0.39 to 0.74 h/sup -1/ when the duct fan was operated (measurements prior to December 1982). This report presents the study design and implementation, describes the monitoring protocols, and provides a complete set of the data collected during the project. 25 references, 29 figures, 42 tables.

  18. Habitat evaluation for outbreak of Yangtze voles (Microtus fortis) and management implications.

    PubMed

    Xu, Zhenggang; Zhao, Yunlin; Li, Bo; Zhang, Meiwen; Shen, Guo; Wang, Yong

    2015-05-01

    Rodent pests severely damage agricultural crops. Outbreak risk models of rodent pests often do not include sufficient information regarding geographic variation. Habitat plays an important role in rodent-pest outbreak risk, and more information about the relationship between habitat and crop protection is urgently needed. The goal of the present study was to provide an outbreak risk map for the Dongting Lake region and to understand the relationship between rodent-pest outbreak variation and habitat distribution. The main rodent pests in the Dongting Lake region are Yangtze voles (Microtus fortis). These pests cause massive damage in outbreak years, most notably in 2007. Habitat evaluation and ecological details were obtained by analyzing the correlation between habitat suitability and outbreak risk, as indicated by population density and historical events. For the source-sink population, 96.18% of Yangtze vole disaster regions were covered by a 10-km buffer zone of suitable habitat in 2007. Historical outbreak frequency and peak population density were significantly correlated with the proportion of land covered by suitable habitat (r = 0.68, P = 0.04 and r = 0.76, P = 0.03, respectively). The Yangtze vole population tends to migrate approximately 10 km in outbreak years. Here, we propose a practical method for habitat evaluation that can be used to create integrated pest management plans for rodent pests when combined with basic information on the biology, ecology and behavior of the target species.

  19. Vascular Access Grafts for Chemotherapy: Use in Forty Patients at M. D. Anderson Hospital

    PubMed Central

    Raaf, John H.

    1979-01-01

    Forty-two arteriovenous grafts were placed to provide vascular access in 40 patients with poor or sclerosed superficial veins. Thirty-nine patients had malignant disease and required chemotherapy, while one patient with aplastic anemia needed frequent transfusions. Thirty-two grafts were placed in the arm (27 straight and 5 loop), and ten in the leg (femoral-femoral loop). Thirty-seven shunts consisted of 6 mm polytetrafluoroethylene (PTFE), and five were 6 mm Dacron®. The straight brachial artery to axillary vein PTFE graft was preferred, while the PTFE femoral loop graft was a satisfactory alternative. The loop arm graft was associated with a high complication rate and is no longer used. Local anesthesia was employed in all cases except for a 3-year-old child. There was no operative mortality and no severe morbidity, despite subsequent myelosuppression by chemotherapeutic agents injected via these grafts. Thirty patients are alive, while ten died of their malignancy. Twenty-six grafts are functional and have been in place an average 4.4 months (range: 1 to 14 mo.). Acceptance by patients and particularly by personnel in the out-patient chemotherapy unit has been enthusiastic. Vascular access grafts can be inserted safely and provide a convenient route for drawing blood samples, and for administering chemotherapy and intermittent intravenous therapy in selected patients with neoplastic disease. ImagesFig. 4. PMID:507972

  20. Measurement of the room temperture R(1) line width of forty-two rubies.

    PubMed

    Benedict, R A; Nester, J F; Kellington, C M

    1967-03-01

    Accurate measurement of the room temperature R(1) fluorescent line width of forty-two ruby laser crystals has been made using a pressure-scanned Fabry-Perot etalon. In forty-one of these rubies the chromium content was nearly the same, and the R(1) line width for all was 5.0 +/- 0.3 A, in agreement with present theories.

  1. 26 CFR 7.48-2 - Election of forty-percent method of determining investment credit for movie and television films...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... investment credit for movie and television films placed in service in a taxable year beginning before January... Election of forty-percent method of determining investment credit for movie and television films placed in... the Tax Reform Act of 1976 (90 Stat. 1595), taxpayers who placed movie or television films...

  2. 26 CFR 7.48-2 - Election of forty-percent method of determining investment credit for movie and television films...

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... investment credit for movie and television films placed in service in a taxable year beginning before January... Election of forty-percent method of determining investment credit for movie and television films placed in... the Tax Reform Act of 1976 (90 Stat. 1595), taxpayers who placed movie or television films...

  3. 26 CFR 7.48-2 - Election of forty-percent method of determining investment credit for movie and television films...

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... investment credit for movie and television films placed in service in a taxable year beginning before January... Election of forty-percent method of determining investment credit for movie and television films placed in... the Tax Reform Act of 1976 (90 Stat. 1595), taxpayers who placed movie or television films...

  4. 26 CFR 7.48-2 - Election of forty-percent method of determining investment credit for movie and television films...

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... investment credit for movie and television films placed in service in a taxable year beginning before January... Election of forty-percent method of determining investment credit for movie and television films placed in... the Tax Reform Act of 1976 (90 Stat. 1595), taxpayers who placed movie or television films...

  5. 26 CFR 7.48-2 - Election of forty-percent method of determining investment credit for movie and television films...

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... investment credit for movie and television films placed in service in a taxable year beginning before January... Election of forty-percent method of determining investment credit for movie and television films placed in... the Tax Reform Act of 1976 (90 Stat. 1595), taxpayers who placed movie or television films...

  6. Effects of neurostimulation for advanced Parkinson’s disease patients on motor symptoms: A multiple-treatments meta-analysas of randomized controlled trials

    PubMed Central

    Xie, Cheng-Long; Shao, Bei; Chen, Jie; Zhou, Yi; Lin, Shi-Yi; Wang, Wen-Wen

    2016-01-01

    Deep brain stimulation (DBS) is the surgical procedure of choice for patients with advanced Parkinson disease (PD). We aim to evaluate the efficacy of GPi (globus pallidus internus), STN (subthalamic nucleus)-DBS and medical therapy for PD. We conducted a systematic review and multiple-treatments meta-analysis to investigate the efficacy of neurostimulation and medical therapy for PD patients. Sixteen eligible studies were included in this analysis. We pooled the whole data and found obvious difference between GPi-DBS versus medical therapy and STN-DBS versus medical therapy in terms of UPDRS scores (Unified Parkinson’s Disease Rating Scale). Meanwhile, we found GPi-DBS had the similar efficacy on the UPDRS scores when compared with STN-DBS. What is more, quality of life, measured by PDQ-39 (Parkinson’s disease Questionnaire) showed greater improvement after GPi-DBS than STN-DBS. Five studies showed STN-DBS was more effective for reduction in medication than GPi-DBS. Overall, either GPi-DBS or STN-DBS was an effective technique to control PD patients’ symptoms and improved their functionality and quality of life. Meanwhile, the UPDRS scores measuring parkinsonian symptoms revealed no significant difference between GPi-DBS and STN-DBS. STN-DBS was more effective for reduction in medication than GPi-DBS. Alternatively, GPi-DBS was more effective for improving the PDQ-39 score than STN-DBS. PMID:27142183

  7. The combined effects of neurostimulation and priming on creative thinking. A preliminary tDCS study on dorsolateral prefrontal cortex

    PubMed Central

    Colombo, Barbara; Bartesaghi, Noemi; Simonelli, Luisa; Antonietti, Alessandro

    2015-01-01

    The role of prefrontal cortex (PFC) in influencing creative thinking has been investigated by many researchers who, while succeeding in proving an effective involvement of PFC, reported suggestive but sometimes conflicting results. In order to better understand the relationships between creative thinking and brain activation in a more specific area of the PFC, we explored the role of dorsolateral PFC (DLPFC). We devised an experimental protocol using transcranial direct-current stimulation (tDCS). The study was based on a 3 (kind of stimulation: anodal vs. cathodal vs. sham) × 2 (priming: divergent vs. convergent) design. Forty-five healthy adults were randomly assigned to one stimulation condition. Participants’ creativity skills were assessed using the Product Improvement subtest from the Torrance Tests of Creative Thinking (TTCT). After 20 min of tDCS stimulation, participants were presented with visual images of common objects. Half of the participants were instructed to visualize themselves using the object in an unusual way (divergent priming), whereas the other half were asked to visualize themselves while using the object in a common way (convergent priming). Priming was aimed at inducing participants to adopt different attitudes toward the creative task. Afterwards, participants were asked to describe all of the possible uses of the objects that were presented. Participants’ physiological activation was recorded using a biofeedback equipment. Results showed a significant effect of anodal stimulation that enhanced creative performance, but only after divergent priming. Participants showed lower skin temperature values after cathodal stimulation, a finding which is coherent with studies reporting that, when a task is not creative or creative thinking is not prompted, people show lower levels of arousal. Differences in individual levels of creativity as assessed by the Product Improvement test were not influential. The involvement of DLPFC in creativity

  8. The combined effects of neurostimulation and priming on creative thinking. A preliminary tDCS study on dorsolateral prefrontal cortex.

    PubMed

    Colombo, Barbara; Bartesaghi, Noemi; Simonelli, Luisa; Antonietti, Alessandro

    2015-01-01

    The role of prefrontal cortex (PFC) in influencing creative thinking has been investigated by many researchers who, while succeeding in proving an effective involvement of PFC, reported suggestive but sometimes conflicting results. In order to better understand the relationships between creative thinking and brain activation in a more specific area of the PFC, we explored the role of dorsolateral PFC (DLPFC). We devised an experimental protocol using transcranial direct-current stimulation (tDCS). The study was based on a 3 (kind of stimulation: anodal vs. cathodal vs. sham) × 2 (priming: divergent vs. convergent) design. Forty-five healthy adults were randomly assigned to one stimulation condition. Participants' creativity skills were assessed using the Product Improvement subtest from the Torrance Tests of Creative Thinking (TTCT). After 20 min of tDCS stimulation, participants were presented with visual images of common objects. Half of the participants were instructed to visualize themselves using the object in an unusual way (divergent priming), whereas the other half were asked to visualize themselves while using the object in a common way (convergent priming). Priming was aimed at inducing participants to adopt different attitudes toward the creative task. Afterwards, participants were asked to describe all of the possible uses of the objects that were presented. Participants' physiological activation was recorded using a biofeedback equipment. Results showed a significant effect of anodal stimulation that enhanced creative performance, but only after divergent priming. Participants showed lower skin temperature values after cathodal stimulation, a finding which is coherent with studies reporting that, when a task is not creative or creative thinking is not prompted, people show lower levels of arousal. Differences in individual levels of creativity as assessed by the Product Improvement test were not influential. The involvement of DLPFC in creativity has

  9. IR Laboratory Astrophysics at Forty: Some Highlights and a Look to the Future

    NASA Astrophysics Data System (ADS)

    Allamandola, Louis John

    2016-06-01

    Space was thought to be chemically barren until about forty years ago. Astrochemistry was in its infancy, the composition of interstellar dust was largely guessed at, the presence of mixed molecular ices in dense molecular clouds was not taken seriously, and the notion of large, gas phase, carbon-rich molecules (PAHs) abundant and widespread throughout the interstellar medium (ISM) was inconceivable. The rapid development of infrared astronomy between 1970 and 1985, especially observations made by the Kuiper Airborne Observatory (KAO) and the Infrared Astronomical Satellite IRAS), which made it possible to measure mid-infrared spectra between 2.5 to 14 µm, changed all that. Since then observations made from ground-based, airborne and orbiting IR telescopes, together with radio and submm observations, have revealed that we live in a Universe that is not a hydrogen-dominated, physicist's paradise, but in a molecular Universe with complex molecules directly interwoven into its fabric. Today we recognize that molecules are an abundant and important component of astronomical objects at all stages of their evolution and that they play important roles in many processes that contribute to the structure and evolution of galaxies. Furthermore, many of these organic molecules are thought to be delivered to habitable planets such as Earth, and their composition may be related to the origin of life. Laboratory astrophysics has been key to making this great progress; progress which has only been made possible thanks to the close collaboration of laboratory experimentalists with astronomers and theoreticians. These collaborations are essential to meet the growing interdisciplinary challenges posed by astrophysics. This talk will touch on some of the milestones that have been reached in IR astrospectroscopy over the past four decades, focusing on the experimental work that revealed the widespread presence of interstellar PAHs and the composition of interstellar/precometary ices

  10. The complete mitochondrial genome of Microtus fortis calamorum (Arvicolinae, Rodentia) and its phylogenetic analysis.

    PubMed

    Jiang, Xianhuan; Gao, Jun; Ni, Liju; Hu, Jianhua; Li, Kai; Sun, Fengping; Xie, Jianyun; Bo, Xiong; Gao, Chen; Xiao, Junhua; Zhou, Yuxun

    2012-05-01

    Microtus fortis is a special resource of rodent in China. It is a promising experimental animal model for the study on the mechanism of Schistosome japonicum resistance. The first complete mitochondrial genome sequence for Microtus fortis calamorum, a subspecies of M. fortis (Arvicolinae, Rodentia), was reported in this study. The mitochondrial genome sequence of M. f. calamorum (Genbank: JF261175) showed a typical vertebrate pattern with 13 protein coding genes, 2 ribosomal RNAs, 22 transfer RNAs and one major noncoding region (CR region).The extended termination associated sequences (ETAS-1 and ETAS-2) and conserved sequence block 1 (CSB-1) were found in the CR region. The putative origin of replication for the light strand (O(L)) of M. f. calamorum was 35bp long and showed high conservation in stem and adjacent sequences, but the difference existed in the loop region among three species of genus Microtus. In order to investigate the phylogenetic position of M. f. calamorum, the phylogenetic trees (Maximum likelihood and Bayesian methods) were constructed based on 12 protein-coding genes (except for ND6 gene) on H strand from 16 rodent species. M. f. calamorum was classified into genus Microtus, Arvcicolinae for the highly phylogenetic relationship with Microtus kikuchii (Taiwan vole). Further phylogenetic analysis results based on the cytochrome b gene ranged from M. f. calamorum to one of the subspecies of M. fortis, which formed a sister group of Microtus middendorfii in the genus Microtus.

  11. 5 CFR 630.302 - Maximum annual leave accumulation-forty-five day limitation.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ...-five day limitation. 630.302 Section 630.302 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT...—forty-five day limitation. (a) The effective date on which an employee (otherwise eligible thereunder... employee's accumulated and accrued annual leave is 30 days or less, he may carry forward the...

  12. 5 CFR 630.302 - Maximum annual leave accumulation-forty-five day limitation.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ...-five day limitation. 630.302 Section 630.302 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT...—forty-five day limitation. (a) The effective date on which an employee (otherwise eligible thereunder... employee's accumulated and accrued annual leave is 30 days or less, he may carry forward the...

  13. 5 CFR 630.302 - Maximum annual leave accumulation-forty-five day limitation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ...-five day limitation. 630.302 Section 630.302 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT...—forty-five day limitation. (a) The effective date on which an employee (otherwise eligible thereunder... employee's accumulated and accrued annual leave is 30 days or less, he may carry forward the...

  14. 5 CFR 630.302 - Maximum annual leave accumulation-forty-five day limitation.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ...-five day limitation. 630.302 Section 630.302 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT...—forty-five day limitation. (a) The effective date on which an employee (otherwise eligible thereunder... employee's accumulated and accrued annual leave is 30 days or less, he may carry forward the...

  15. Rocket and Laboratory Experiments in Astrophysics— Validation and Verification of the Next Generation FORTIS

    NASA Astrophysics Data System (ADS)

    McCandliss, Stephan

    We submit herein a proposal describing plans for further development of a Next Generation Far-UV Off Rowland-circle Telescope for Imaging and Spectroscopy (FORTIS). The goal of the proposal is to demonstrate the scientific utility of multiobject spectroscopy over wide angular fields in the far-UV with investigations of: the blue straggler population in the Globular Cluster M10; low metallicity star formation in the Magellanic Bridge; shock structures Cygnus Loop supernova remnant; a search for unidentified emissions in star-forming galaxies; and potentially an, as yet, unnamed comet as a target of opportunity. FORTIS is a pathfinder for developing the technologies necessary to enable far-UV spectroscopic surveys. Such surveys will allow us to probe problems relevant to the formation of large scale structures, the origin and evolution of galaxies, and the formation and evolution of stars from interstellar gas. In combination with existing and future spectroscopic surveys, they will provide a complete and compelling panchromatic picture of the observable universe. Next generation FORTIS will fly as a sounding rocket borne instrument and incorporate a number of unique technologies, including the Next Generation MicroShutter Array (NGMSA), which provides for the simultaneous acquisition of spectra from multiple objects within a wide angular field. The NGMSA will be controlled by an autonomous targeting system capable of identifying multiple objects on-the-fly for further spectral analysis in the short time afforded to far-UV observations from a sounding rocket 400 seconds. We will also incorporate long life microchannel plate (MCP) detectors that have have high open area ratios, providing for increased quantum efficiency, and improved resistance to gain sag, allowing operation at higher count rate. Recent flight experience with the first generation FORTIS has provided guidance to improving the science return of the next generation FORTIS. Our plans for a rigorous

  16. Firearm-related mortality: a review of four hundred-forty four deaths in Diyarbakir, Turkey between 1996 and 2001.

    PubMed

    Goren, Suleyman; Subasi, Mehmet; Tirasci, Yasar; Kemaloglu, Serdar

    2003-11-01

    The current study is based on a retrospective investigation of firearm deaths in Diyarbakir, which were autopsied by the Diyarbakir Branch of the Council of Forensic Medicine during the 6- year period. Four hundred-forty four deaths were investigated from January 1996 through December 2001, including homicide (296 cases, 66.7%), suicide (120 cases, 27%) and accidental shootings (28 cases, 6.3%). The age range of all firearm deaths in the study period was 5 to 75 years with a median age of 29.8 years. The majority were in the groups aged 16-25 years (38.7%). In the homicide group, 248 subjects (83.8%) were male, and 48 (16.2%) were female. The 31.1% of the homicide victims were in the group aged at 20-30 years. Of the 120 suicide victims, 56 (46.7%) were in the group aged 16-20 years. The head was by far the favoured site, accounting for 82 (68.3%) deaths: entry wounds in the right temple accounted for 72 of these. Twenty-eight cases were accidental shootings and 18 of them were male (64.3%). Twelve of the 28 accidental victims (42.9%) were in the group aged 0-10 years. The eight cases were due to their own accidental shootings, and the remaining 20 cases were shot by others. Our findings show that the contributing factors for increasing death by firearm are terrorists' activities, traditional habits of obtaining and using guns and blood feuds.

  17. Survey of Yucca Mountain, Forty-Mile Canyon, and Jackass Flats in Nye County, Nevada for desert tortoise, Gopherus agassizii

    SciTech Connect

    Medica, P.A.; O`Farrell, T.P.; Collins, E.

    1981-10-01

    The objective of this brief survey was to determine if G. agassizii is present west of Forty-Mile Canyon in the Yucca Mountain.. area, or along the major access roads which lead through Jackass Flats to Forty-Mile Canyon and Yucca Mountain

  18. A Forty-Year Retrospective 1950-1990: The Metropolitan Toronto and Region Conservation Authority's Conservation Education Programmes.

    ERIC Educational Resources Information Center

    Carr, Allen Terry

    1996-01-01

    Recounts the growth of Conservation Authorities in Ontario from the first partnerships between schools and conservation in the 1950s, to the opening of a pioneer village, flood control dam, nature trails, and residential conservation education centers through the 1960s and 1970s. Increased public environmental concern sparked more growth in the…

  19. Bristow-Latarjet Technique: Still a Very Successful Surgery for Anterior Glenohumeral Instability - A Forty Year One Clinic Experience

    PubMed Central

    Ruci, Vilson; Duni, Artid; Cake, Alfred; Ruci, Dorina; Ruci, Julian

    2015-01-01

    AIM: To evaluate the functional outcomes of the Bristow-Latarjet procedure in patients with recurrent anterior glenohumeral instability. PATIENTS AND METHODS: Personal clinical records of 42 patients with 45 operated shoulders were reviewed retrospectively. Patient age at time of first dislocation, injury mechanism, and number of recurring dislocations before surgery were recorded. The overall function and stability of the shoulder was evaluated. RESULTS: Thirty five (78%) of the scapulohumeral humeral instabilities were caused by trauma. The mean number of recurring dislocations was 9 (95% confidence interval [CI], 0–18); one patient had had 17 recurrences. Mean follow-up 46 months (95% CI, 16-88). No dislocation happened postoperatively. Four patients have fibrous union (9%). Only two had clinical sign of pain and discomfort. One of them was reoperated for screw removal with very good post-operative result. The overall functional outcome was good, with a mean Rowe score of 88 points (95% CI, 78–100). Scores of 27 (64%) of the patients were excellent, 9 (22%) were good, 4 (9.5%) were fair, and 2 (4.5%) were poor. CONCLUSION: The Bristow-Latarjet procedure is a very good surgical treatment for recurrent anterior-inferior instability of the glenohumeral joint. It must not be used for multidirectional instability or psychogenic habitual dislocations. PMID:27275242

  20. A forty-three year museum study of northern cricket frog (Acris crepitans) abnormalities in Arkansas: upward trends and distributions.

    PubMed

    McCallum, Malcolm L; Trauth, Stanley E

    2003-07-01

    The northern cricket frog (Acris crepitans) is a resident of streams, rivers, and wetlands of eastern North America. We documented abnormalities in A. crepitans housed in the Arkansas State University Museum of Zoology Herpetology Collection. Abnormality frequency increased from 1957 to 2000 (chi 2 = 43.76, df = 3, P < 0.001). From 1957 through 1979 only 3.33% of specimens were unusual. This rate was 6.87% during the 1990s, and in 2000 it was 8.48%. High frequencies of abnormalities were identified in the following Ozark highland counties: Sharp, Lawrence, and Randolph. We observed 104 abnormalities among 1,464 frogs (7.10%). The differential abnormality frequencies observed between the Arkansas lowlands and highlands are striking. The Ozarks had significantly higher frequencies of abnormalities than other Arkansas regions (chi 2 = 59.76, df = 4, P < 0.001). The Ouachita Mountains had significantly higher frequencies than the Gulf Coastal Plain, Delta, or Arkansas River Valley (chi 2 = 13.172, df = 3, P < 0.01). There was no difference in abnormality frequency between the Gulf Coastal Plain, Delta, and Arkansas River Valley (chi 2 = 0.422, df = 2, P > 0.70). Proposed hypotheses for distributions include: 1) A. crepitans might possess naturally high abnormality levels, and land use practices of the Delta may reduce this variability; 2) an unknown xenobiotic may be in Ozark streams causing increased numbers of abnormalities; 3) the museum's collection effort may be skewed; 4) Delta habitat might be more favorable for green tree frogs (Hyla cinerea) allowing this species to drive out A. crepitans through competition; here, abnormal metamorphs are not detected because they are even less competitive than normal individuals.

  1. Signature of forty years of artificial selection in U.S. Holstein cattle identified by long-range frequency analyses

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Three groups of U.S. Holstein cattle were analyzed for selection signature of artificial selection since 1964 using long-range frequency measures. The three groups included Holsteins unselected since 1964, contemporary Holsteins, and an elite line of contemporary Holsteins. Long-range frequencies in...

  2. Stifle Lameness in Cattle at Two Veterinary Teaching Hospitals: A Retrospective Study of Forty-two Cases

    PubMed Central

    Ducharme, N. G.; Stanton, M. E.; Ducharme, G. R.

    1985-01-01

    Records of two veterinary teaching hospitals from January 1, 1976 to June 1, 1982 were searched for diagnoses of stifle lameness. Forty-two records were found and information was recorded regarding signalment, history and clinical presentation. The following abnormalities were associated with stifle lameness: subchondral bone cyst (18 cases), joint instability (15 cases), degenerative joint disease (12 cases), cranial cruciate ligament injury (9 cases), cytological or bacteriological evidence of sepsis (9 cases), collateral ligament injury (3 cases), femorotibial luxation (2 cases) and intra-articular fracture (2 cases). The duration of lameness presentation ranged from 0.3 to 24 weeks and the mean follow-up period was 20.47 ± 11.44 months (three animals were lost to follow-up). Animals (n = 15) with subchondral bone cysts as the sole association with lameness presented at an early age (range — 6 to 18 months) and apparently regardless of treatment, had a good prognosis as determined by 75% (three lost to follow-up) returning to their intended function. Cattle (n = 9) with septic arthritis were presented at an age ranging from two months to seven years and only 22.2% returned to function. Cattle (n = 15) with joint instability presented at an age varying from nine months to 13 years also did poorly as only 26.6% returned to function. ImagesFigure 1.Figure 2. PMID:17422551

  3. Ontogeny of the cranial skeleton in a Darwin's finch (Geospiza fortis)

    PubMed Central

    Genbrugge, Annelies; Heyde, Anne-Sophie; Adriaens, Dominique; Boone, Matthieu; Van Hoorebeke, Luc; Dirckx, Joris; Aerts, Peter; Podos, Jeffrey; Herrel, Anthony

    2011-01-01

    Darwin's finches are a model system in ecological and evolutionary research, but surprisingly little is known about their skull morphology and development. Indeed, only the early beak development and external variation in adult beak shape has been studied. Understanding the development of the skull from embryo up to the adult is important to gain insights into how selection acts upon, and drives, variation in beak shape. Here, we provide a detailed description of the skeletal development of the skull in the medium ground finch (Geospiza fortis). Although the ossification sequence of the cranial elements is broadly similar to that observed for other birds, some differences can be observed. Unexpectedly, our data show that large changes in skull shape take place between the nestling and the juvenile phases. The reorientation of the beak, the orbit and the formation of well-developed processes and cristae suggest that these changes are likely related to the use of the beak after leaving the nest. This suggests that the active use of the jaw muscles during seed cracking plays an important role in shaping the adult skull morphology and may be driving some of the intra-specific variation observed in species such as G. fortis. Investigating the development of the jaw muscles and their interaction with the observed ossification and formation of the skull and lower jaw would allow further insights into the ecology and evolution of beak morphology in Darwin's finches. PMID:21599660

  4. Effect of population density on reproduction in Microtus fortis under laboratory conditions.

    PubMed

    Han, Qunhua; Zhang, Meiwen; Guo, Cong; Shen, Guo; Wang, Yong; Li, Bo; Xu, Zhenggang

    2014-06-01

    Between December 2011 and March 2012, the reproductive characteristics of Microtus fortis reared in the laboratory at different population densities were assessed. In all, 258 male and female voles were randomly divided into 4 groups and reared at densities of 2, 4, 6, and 8 animals per cage (sex ratio: 1:1). The results showed that the pregnancy rate (χ2 = 21.671, df = 3, P < 0.001) and first farrowing interval (F = 12.355, df = 3, P < 0.001) were significantly different among the different population density groups, but the mean litter size (mean ± SD) was not (F = 2.669, df = 3, P > 0.05). In particular, the reproductive index and sex hormone levels showed a significant difference among the different density groups studied.

  5. Correlations Between Cutaneous Malignant Melanoma and Other Cancers: An Ecological Study in Forty European Countries

    PubMed Central

    Serrano, Pablo Fernandez-Crehuet; Serrano, Jose Luis Fernandez-Crehuet; Allam, Mohamed Farouk; Navajas, Rafael Fernandez-Crehuet

    2016-01-01

    Background: The presence of noncutaneous neoplasms does not seem to increase the risk of cutaneous malignant melanoma; however, it seems to be associated with the development of other hematological, brain, breast, uterine, and prostatic neoplasms. An ecological transversal study was conducted to study the geographic association between cutaneous malignant melanoma and 24 localizations of cancer in forty European countries. Methods: Cancer incidence rates were extracted from GLOBOCAN database of the International Agency for Research on Cancer. We analyzed the age-adjusted and gender-stratified incidence rates for different localizations of cancer in forty European countries and calculated their correlation using Pearson's correlation test. Results: In males, significant correlations were found between cutaneous malignant melanoma with testicular cancer (r = 0.83 [95% confidence interval (CI): 0.68–0.89]), myeloma (r = 0.68 [95% CI: 0.46–0.81]), prostatic carcinoma (r = 0.66 [95% CI: 0.43–0.80]), and non-Hodgkin lymphoma (NHL) (r = 0.63 [95% CI: 0.39–0.78]). In females, significant correlations were found between cutaneous malignant melanoma with breast cancer (r = 0.80 [95% CI: 0.64–0.88]), colorectal cancer (r = 0.72 [95% CI: 0.52–0.83]), and NHL (r = 0.71 [95% CI: 0.50–0.83]). Conclusions: These correlations call to conduct new studies about the epidemiology of cancer in general and cutaneous malignant melanoma risk factors in particular. PMID:27217938

  6. "Storm Alley" on Saturn and "Roaring Forties" on Earth: two bright phenomena of the same origin

    NASA Astrophysics Data System (ADS)

    Kochemasov, G. G.

    2009-04-01

    "Storm Alley" on Saturn and "Roaring Forties' on Earth: two bright phenomena of the same origin. G. Kochemasov IGEM of the Russian Academy of Sciences, Moscow, Russia, kochem.36@mail.ru Persisting swirling storms around 35 parallel of the southern latitude in the Saturnian atmosphere and famous "Roaring Forties" of the terrestrial hydro- and atmosphere are two bright phenomena that should be explained by the same physical law. The saturnian "Storm Alley" (as it is called by the Cassini scientists) is a stable feature observed also by "Voyager". The Earth's "Roaring Forties" are well known to navigators from very remote times. The wave planetology [1-3 & others] explains this similarity by a fact that both atmospheres belong to rotating globular planets. This means that the tropic and extra-tropic belts of these bodies have differing angular momenta. Belonging to one body these belts, naturally, tend to equilibrate their angular momenta mainly by redistribution of masses and densities [4]. But a perfect equilibration is impossible as long as a rotating body (Saturn or Earth or any other) keeps its globular shape due to mighty gravity. So, a contradiction of tropics and extra-tropics will be forever and the zone mainly between 30 to 50 degrees in both hemispheres always will be a zone of friction, turbulence and strong winds. Some echoes of these events will be felt farther poleward up to 70 degrees. On Earth the Roaring Forties (40˚-50˚) have a continuation in Furious Fifties (50˚-60˚) and Shrieking (Screaming) Sixties (below 60˚, close to Antarctica). Below are some examples of excited atmosphere of Saturn imaged by Cassini. PIA09734 - storms within 46˚ south; PIA09778 - monitoring the Maelstrom, 44˚ north; PIA09787 - northern storms, 59˚ north; PIA09796 - cloud details, 44˚ north; PIA10413 - storms of the high north, 70˚ north; PIA10411 - swirling storms, "Storm Alley", 35˚ south; PIA10457 - keep it rolling, "Storm Alley", 35˚ south; PIA10439 - dance

  7. Neutron capture therapy: Years of experimentation---Years of reflection

    SciTech Connect

    Farr, L.E.

    1991-12-16

    This report describes early research on neutron capture therapy over a number of years, beginning in 1950, speaking briefly of patient treatments but dwelling mostly on interpretations of our animal experiments. This work carried out over eighteen years, beginning over forty years ago. Yet, it is only fitting to start by relating how neutron capture therapy became part of Brookhaven's Medical Research Center program.

  8. A Microtus fortis protein, serum albumin, is a novel inhibitor of Schistosoma japonicum schistosomula

    PubMed Central

    Li, Rong; Wu, Guo-Jun; Xiong, De-Hui; Gong, Qiang; Yu, Ruan-Jing; Hu, Wei-Xin

    2013-01-01

    Schistosomiasis is an endemic parasite disease and praziquantel is the only drug currently in use to control this disease. Experimental and epidemiological evidence strongly suggests that Microtus fortis ( Mf ) is a naturally resistant vertebrate host of Schistosoma japonicum . In the present study, we found that Mf serum albumin ( Mf -albumin) and the conditioned medium of pcDNA3.1- Mf -albumin caused 46.2% and 38.7% schistosomula death rates in 96 h, respectively, which were significantly higher than that of the negative control (p < 0.05). We also found that mice injected with Mf -albumin had a 43.5% reduction in worm burden and a 48.1% reduction in liver eggs per gram (p < 0.05) in comparison to the control animals. To characterise the mechanisms involved in clearance, schistosomula were incubated with fluorescein isothiocyanate-labelled Mf -albumin and fluorescent enrichment effects were found in the gut lumen of schistosomula after 48 h of incubation. Next, digestive tract excretions from schistosomula were collected and the sensitivity of Mf -albumin to digestive tract excretions was evaluated. The results indicated that schistosomula digestive tract excretions showed indigestibility of Mf -albumin. The death of schistosomula could be partially attributed to the lack of digestion of Mf -albumin by digestive tract excretions during the development of the schistosomula stage. Therefore, these data indicate the potential of Mf -albumin as one of the major selective forces for schistosomiasis. PMID:24271043

  9. The ant's estimation of distance travelled: experiments with desert ants, Cataglyphis fortis.

    PubMed

    Sommer, S; Wehner, R

    2004-01-01

    Foraging desert ants, Cataglyphis fortis, monitor their position relative to the nest by path integration. They continually update the direction and distance to the nest by employing a celestial compass and an odometer. In the present account we addressed the question of how the precision of the ant's estimate of its homing distance depends on the distance travelled. We trained ants to forage at different distances in linear channels comprising a nest entrance and a feeder. For testing we caught ants at the feeder and released them in a parallel channel. The results show that ants tend to underestimate their distances travelled. This underestimation is the more pronounced, the larger the foraging distance gets. The quantitative relationship between training distance and the ant's estimate of this distance can be described by a logarithmic and an exponential model. The ant's odometric undershooting could be adaptive during natural foraging trips insofar as it leads the homing ant to concentrate the major part of its nest-search behaviour on the base of its individual foraging sector, i.e. on its familiar landmark corridor.

  10. Dermatoglyphics of digitopalmar complex in forty male patients affected by rheumatoid arthritis--quantitative analysis.

    PubMed

    Cvjeticanin, Miljenko; Jajić, Zrinka; Jajić, Ivo

    2009-01-01

    Quantitative analysis of digitopalmar ridge count was performed in forty male patients with rheumatoid arthritis to evaluation of genetic factors in that disease. Twenty five variables (ridge count on each of ten fingers, their sum on five and ten fingers, four traits on each palm, i. e. ridge count between a-b, b-c and c-d triradii, their sum on each and both palm and at angle on two palms and their bilateral sum) were determined. The data thus obtained were compared with digitopalmar prints of 200 healthy men who served as a control group. A significant difference from the control group was found in eight variables. Ridge count was increased on the first and fifth finger bilaterally, on the fourth right finger tip, and their sum on each, and both fists. Accordingly, a polygenic system identical in some loci to the polygenic system predisposing to rheumatoid arthritis susceptibility might be found responsible for the dermatoglyphic pattern development. That means that they could used, and that is the aim of this study, as a diagnostic tool in rheumatic diseases.

  11. Trajectories of Marijuana Use from Adolescence to Adulthood as Predictors of Unemployment Status in the Early Forties

    PubMed Central

    Zhang, Chenshu; Brook, Judith S.; Leukefeld, Carl G.; Brook, David W.

    2016-01-01

    Objectives To study the degree to which individuals in different trajectories of marijuana use are similar or different in terms of unemployment status at mean age 43. Methods We gathered longitudinal data on a prospective cohort taken from a community sample (N = 548). Forty nine percent of the original participants were females. Over 90% of the participants were white. The participants were followed from adolescence to early midlife. The mean ages of participants at the follow-up interviews were 14.1, 16.3, 22.3, 27.0, 31.9, 36.6, and 43.0, respectively. We used the growth mixture modeling (GMM) approach to identify the trajectories of marijuana use over a 29 year period. Results Five trajectories of marijuana use were identified: chronic users/decreasers (8.3%), quitters (18.6%), increasing users (7.3%), chronic occasional users (25.6%), and nonusers/experimenters (40.2%). Compared with nonusers/experimenters, chronic users/decreasers had a significantly higher likelihood of unemployment at mean age 43 (Adjusted Odds Ratio =3.51, 95% Confidence Interval = 1.13 – 10.91), even after controlling for the covariates. Conclusions and Scientific Significance The results of the associations between the distinct trajectories of marijuana use and unemployment in early midlife indicate that it is important to develop intervention programs targeting chronic marijuana use as well as unemployment in individuals at this stage of development. Results from this study should encourage clinicians, teachers, and parents to assess and treat chronic marijuana use in adolescents. PMID:26991779

  12. How to find home backwards? Navigation during rearward homing of Cataglyphis fortis desert ants.

    PubMed

    Pfeffer, Sarah E; Wittlinger, Matthias

    2016-07-15

    Cataglyphis ants are renowned for their impressive navigation skills, which have been studied in numerous experiments during forward locomotion. However, the ants' navigational performance during backward homing when dragging large food loads has not been investigated until now. During backward locomotion, the odometer has to deal with unsteady motion and irregularities in inter-leg coordination. The legs' sensory feedback during backward walking is not just a simple reversal of the forward stepping movements: compared with forward homing, ants are facing towards the opposite direction during backward dragging. Hence, the compass system has to cope with a flipped celestial view (in terms of the polarization pattern and the position of the sun) and an inverted retinotopic image of the visual panorama and landmark environment. The same is true for wind and olfactory cues. In this study we analyze for the first time backward-homing ants and evaluate their navigational performance in channel and open field experiments. Backward-homing Cataglyphis fortis desert ants show remarkable similarities in the performance of homing compared with forward-walking ants. Despite the numerous challenges emerging for the navigational system during backward walking, we show that ants perform quite well in our experiments. Direction and distance gauging was comparable to that of the forward-walking control groups. Interestingly, we found that backward-homing ants often put down the food item and performed foodless search loops around the left food item. These search loops were mainly centred around the drop-off position (and not around the nest position), and increased in length the closer the ants came to their fictive nest site.

  13. Far-UV observations of comet C/2012 S1 (ISON) with FORTIS

    NASA Astrophysics Data System (ADS)

    McCandliss, Stephan R.; Feldman, Paul D.; Weaver, Harold A.; Fleming, Brian; Redwine, Keith; Li, Mary J.; Kutyrev, Alexander; Moseley, Samuel H.

    2015-01-01

    Far-UV imagery and objective grating spectroscopy of comet C/2012 S1 (ISON) were acquired from NASA sounding rocket 36.296 UG, launched on 20 November 2013 at 04:40 MST (20.48 Nov 2013 UT), 8.32 days pre-perihelion, from the White Sands Missile Range, NM. The comet was 0.1° below ground horizon, 0.44 AU from the Sun, 0.86 AU from the Earth, and at a solar elongation of 26.3°. The payload reached an apogee of 279 km and the total time pointed at the comet was 353 s. At the time of launch ISON was undergoing a factor of 5 increase in water production rate, going from 3.5e29 to 19.6e29 molecules s-1between 19.6 and 21.6 Nov (Combi et al. 2014), marking what is thought to be a final fragmentation event (Sekanina & Kracht 2014). Our instrument, a wide-field multi-object spectro-telescope called FORTIS (Far-UV Off Rowland-circle Telescope for Imaging and Spectroscopy), observed Lyα emissions in an objective grating mode through an open microshutter array, developed at the Goddard Space Flight Center, over a (1/2°)2 field-of-view. After accounting for slit losses and deadtime corrections we find a preliminary lower limit to the Lyα surface brightness of ~ 400 kilorayleighs, yielding a hydrogen production rate of QH ~ 5e29 atoms s-1, in reasonable agreement with the Combi result. We also acquired a broadband image of the comet in the 1280 to 1900 Å bandpass. This image shows a drop in count rate proportional to altitude caused by increased absorption of cometary emissions by terrestrial O2 located in the lower thermosphere. O2 absorption acts as a selective time dependent filter that attenuates cometary emissions from different atomic and molecular species at different rates during descent. Preliminary analysis suggests that the dominant species in a (1e5 km)2 nuclear region is neutral carbon. The radial profile in comparison to a Haser model suggests that the C parent molecule had a lifetime (at 1 AU) ~ 105 s; much shorter than the expected lifetime of CO. We

  14. Forty-first annual report of the Director of the United States Geological Survey

    USGS Publications Warehouse

    Smith, George Otis

    1920-01-01

    Especially gratifying has been the popular demand for topographic maps, the increase in sales this year being 70 per cent. The number of all publications—books and maps—distributed during the year exceeded the number printed this year, this disproving the common assertion that Government publications simply accumulate until they become only waste paper. Indeed, an embarrassing feature of much of the correspondence during the year has been the thousands of requests for reports that were out of print, and more reprints than usual of exhausted editions have been authorized to meet an insistent demand. The public is making use of the publications of the Geological Survey as never before.

  15. 37 CFR 201.12 - Recordation of certain contracts by cable systems located outside of the forty-eight contiguous...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2010-07-01 2010-07-01 false Recordation of certain contracts by cable systems located outside of the forty-eight contiguous States. 201.12 Section 201.12... GENERAL PROVISIONS § 201.12 Recordation of certain contracts by cable systems located outside of the...

  16. 37 CFR 201.12 - Recordation of certain contracts by cable systems located outside of the forty-eight contiguous...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 37 Patents, Trademarks, and Copyrights 1 2011-07-01 2011-07-01 false Recordation of certain contracts by cable systems located outside of the forty-eight contiguous States. 201.12 Section 201.12... GENERAL PROVISIONS § 201.12 Recordation of certain contracts by cable systems located outside of the...

  17. "Fortis/Lenis" Revisited One More Time: The Aerodynamics of Some Oral Stop Contrasts in Three Continents

    ERIC Educational Resources Information Center

    Butcher, Andrew

    2004-01-01

    The terms "fortis" and "lenis" are variously regarded as having one single underlying phonetic correlate or many. An exploratory analysis of acoustic and aerodynamic data on contrasting stop series in a number of European and non-European languages confirms that a significant variation in peak intra-oral pressure and in articulatory stricture…

  18. The Forty-Eight-Hour Rule: Emotional Engagement and the Student Athlete

    ERIC Educational Resources Information Center

    Mueller, Alan C. R.

    2009-01-01

    Several years ago, the author taught a course called First-Year experience. A student named Sean mentioned that he played "water pong." Sean, a high-achieving student who was also a member of the lacrosse team, explained that water pong was a game with the rules of beer pong, using water rather than beer. Sean volunteered an explanation of his…

  19. Runners in their forties dominate ultra-marathons from 50 to 3,100 miles

    PubMed Central

    Zingg, Matthias Alexander; Rüst, Christoph Alexander; Rosemann, Thomas; Lepers, Romuald; Knechtle, Beat

    2014-01-01

    OBJECTIVES: This study investigated performance trends and the age of peak running speed in ultra-marathons from 50 to 3,100 miles. METHODS: The running speed and age of the fastest competitors in 50-, 100-, 200-, 1,000- and 3,100-mile events held worldwide from 1971 to 2012 were analyzed using single- and multi-level regression analyses. RESULTS: The number of events and competitors increased exponentially in 50- and 100-mile events. For the annual fastest runners, women improved in 50-mile events, but not men. In 100-mile events, both women and men improved their performance. In 1,000-mile events, men became slower. For the annual top ten runners, women improved in 50- and 100-mile events, whereas the performance of men remained unchanged in 50- and 3,100-mile events but improved in 100-mile events. The age of the annual fastest runners was approximately 35 years for both women and men in 50-mile events and approximately 35 years for women in 100-mile events. For men, the age of the annual fastest runners in 100-mile events was higher at 38 years. For the annual fastest runners of 1,000-mile events, the women were approximately 43 years of age, whereas for men, the age increased to 48 years of age. For the annual fastest runners of 3,100-mile events, the age in women decreased to 35 years and was approximately 39 years in men. CONCLUSION: The running speed of the fastest competitors increased for both women and men in 100-mile events but only for women in 50-mile events. The age of peak running speed increased in men with increasing race distance to approximately 45 years in 1,000-mile events, whereas it decreased to approximately 39 years in 3,100-mile events. In women, the upper age of peak running speed increased to approximately 51 years in 3,100-mile events. PMID:24626948

  20. IDEA at Age Forty: Weathering Common Core Standards and Data Driven Decision Making

    ERIC Educational Resources Information Center

    Bicehouse, Vaughn; Faieta, Jean

    2017-01-01

    Special education, a discipline that aims to provide specialized instruction to meet the unique needs of each child with a disability, has turned 40 years old in the United States. Ever since the passage of the Education for All Handicapped Children Act (P.L. 94-142) in 1975, every state has been directed to provide a free and appropriate…

  1. Forty-sixth annual report of the Director of the Geological Survey

    USGS Publications Warehouse

    Smith, George Otis

    1925-01-01

    SIR: The appropriations made directly for the work of the Geological Survey for the fiscal year 1925 included 10 items, amounting to $1,735,423. In addition $110,000, to be disbursed under the direction of the Public Printer, was appropriated for printing the reports of the Survey, and allotments of $10,000 for miscellaneous printing and binding and of $4,944.75 for miscellaneous supplies were made to the Survey from appropriations for the Interior Department. A detailed statement of the amounts appropriated and expended is given at the end of this report. The balance shown is $15,175.31. Cooperation with the States and other public agencies continued as in other years. The value of the mapping and investigative work of the Survey and the necessity of expediting the completion of this physical inventory of the. country's resources is now so widely recognized that 37 States as well as many counties and municipalities shared with the Federal Government in meeting the cost. The total amount thus contributed was $739, 537. 94. Funds aggregating $231,208.90 were placed to the credit of the Geological Survey for services rendered to other Government bureaus and offices. Balances at the end of the year amounted to about $15,000, and the total expenditure, measuring the amount of work accomplished during the year, was $2,690,994.53.

  2. Who Produces Ianthelline? The Arctic Sponge Stryphnus fortis or its Sponge Epibiont Hexadella dedritifera: a Probable Case of Sponge-Sponge Contamination.

    PubMed

    Cárdenas, Paco

    2016-04-01

    The bromotyrosine derivative ianthelline was isolated recently from the Atlantic boreo-arctic deep-sea sponge Stryphnus fortis, and shown to have clear antitumor and antifouling effects. However, chemosystematics, field observations, and targeted metabolic analyses (using UPLC-MS) suggest that ianthelline is not produced by S. fortis but by Hexadella dedritifera, a sponge that commonly grows on S. fortis. This case highlights the importance of combining taxonomic and ecological knowledge to the field of sponge natural products research.

  3. The Canadian cigar and tobacco journal in the forties: a remembrance.

    PubMed

    Warsh, Cheryl Krasnick

    2006-01-01

    This paper is a period snapshot of the life and times of Canadian smoking culture, filtered through "The Canadian Cigar and Tobacco Journal" (the industry's trade paper) from 1943-1949. "The Journal" provided a vivid portrait of neighbourhood tobacconists, travelling salesman, wholesalers and factory workers, homemakers and entrepreneurs. I discuss the role of Jews in the industry, as manufacturers and retailers. "The Journal" evokes the dangers of the retail trade, such as armed robberies, as well as the dangers of wartime. There is also the parallel danger of tobacco smoking, which, although not explicitly defined as risky behaviour by physicians, nonetheless is apparent to consumers. World War II is a dominant feature of "The Journal," and the celebration of wartime tobacco consumption is epitomized by Winston Churchill and other heroic smokers. Women's increased economic participation during the war years, and postwar demobilization, is reflected in "The Journal." Finally I discuss the growing targeting of children as potential consumers of tobacco.

  4. Neutron capture therapy: Years of experimentation---Years of reflection

    SciTech Connect

    Farr, L.E.

    1991-12-16

    This report describes early research on neutron capture therapy over a number of years, beginning in 1950, speaking briefly of patient treatments but dwelling mostly on interpretations of our animal experiments. This work carried out over eighteen years, beginning over forty years ago. Yet, it is only fitting to start by relating how neutron capture therapy became part of Brookhaven`s Medical Research Center program.

  5. Sexual Complaints, Pelvic Floor Symptoms, and Sexual Distress in Women over Forty

    PubMed Central

    Knoepp, Leise R.; Shippey, Stuart H.; Chen, Chi Chiung Grace; Cundiff, Geoffrey W.; Derogatis, Leonard R.; Handa, Victoria L.

    2011-01-01

    Introduction The American Psychiatric Association recommends considering sexually related personal distress when assessing female sexual dysfunction. Currently, there is little data regarding the impact of sexual complaints on sexual distress. Aim To investigate the association between sexual complaints and perceived sexual distress in a population of ambulatory adult women. Methods Using the short forms of the Personal Experiences Questionnaire and Pelvic Organ Prolapse/Urinary Incontinence Sexual Function Questionnaire, we assessed sexual complaints among 305 women seeking outpatient gynecologic care. Depressive symptoms were quantified using the Center for Epidemiologic Studies Depression (CESD) score. Sexual distress was measured using the Female Sexual Distress Scale (FSDS). Using multivariable logistic regression, we compared sexual complaints between distressed and nondistressed women. Main Outcome Measures Sexual distress, defined by FSDS score ≥15. Results FSDS scores were available for 292/305 participants. Seventy-six (26%) scores reflected distress. Distressed women were more likely to be younger (55.2 ± 1.0 years vs. 56.7 ± 0.8 years, P = 0.017); have higher CESD scores (16.6 vs. 9.5, P = 0.001); and report decreased arousal (56.8% vs. 25.1%, P = 0.001), infrequent orgasm (54% vs. 28.8%, P = 0.001), and dyspareunia (39.7% vs. 10.6%, P = 0.001). Women with sexual distress were also more likely to report sexual difficulty related to pelvic floor symptoms, including urinary incontinence with sexual activity (9% vs. 1.3%, P = 0.005), sexual avoidance due to vaginal prolapse (13.9% vs. 1%, P = 0.001), or sexual activity restriction due to fear of urinary incontinence (14.9% vs. 0.5%, P = 0.001). After multivariate analysis, sexual distress was significantly associated with dyspareunia (odds ratio [OR] 3.11, P = 0.008) and depression score (OR 1.05, P = 0.006), and inversely associated with feelings of arousal during sex (OR 0.19, P = 0.001). Conclusion

  6. Canadian Cardiovascular Society/Canadian Anesthesiologists' Society/Canadian Heart Rhythm Society joint position statement on the perioperative management of patients with implanted pacemakers, defibrillators, and neurostimulating devices.

    PubMed

    Healey, Jeff S; Merchant, Richard; Simpson, Chris; Tang, Timothy; Beardsall, Marianne; Tung, Stanley; Fraser, Jennifer A; Long, Laurene; van Vlymen, Janet M; Manninen, Pirjo; Ralley, Fiona; Venkatraghavan, Lashmi; Yee, Raymond; Prasloski, Bruce; Sanatani, Shubhayan; Philippon, François

    2012-01-01

    There are more than 200,000 Canadians living with permanent pacemakers or implantable defibrillators, many of whom will require surgery or invasive procedures each year. They face potential hazards when undergoing surgery; however, with appropriate planning and education of operating room personnel, adverse device-related outcomes should be rare. This joint position statement from the Canadian Cardiovascular Society (CCS) and the Canadian Anesthesiologists' Society (CAS) has been developed as an accessible reference for physicians and surgeons, providing an overview of the key issues for the preoperative, intraoperative, and postoperative care of these patients. The document summarizes the limited published literature in this field, but for most issues, relies heavily on the experience of the cardiologists and anesthesiologists who contributed to this work. This position statement outlines how to obtain information about an individual's type of pacemaker or implantable defibrillator and its programming. It also stresses the importance of determining if a patient is highly pacemaker-dependent and proposes a simple approach for nonelective evaluation of dependency. Although the document provides a comprehensive list of the intraoperative issues facing these patients, there is a focus on electromagnetic interference resulting from electrocautery and practical guidance is given regarding the characteristics of surgery, electrocautery, pacemakers, and defibrillators which are most likely to lead to interference. The document stresses the importance of preoperative consultation and planning to minimize complications. It reviews the relative merits of intraoperative magnet use vs reprogramming of devices and gives examples of situations where one or the other approach is preferable.

  7. Digital Archives - Thomas M. Bown's Bighorn Basin Maps: The Suite of Forty-Four Office Master Copies

    USGS Publications Warehouse

    McKinney, Kevin C.

    2001-01-01

    This CD-ROM is a digitally scanned suite of master 'locality' maps produced by Dr. Thomas M. Bown. The maps are archived in the US Geological Survey Field Records. The maps feature annual compilations of newly established fossil (nineteen 7.5 degree maps) of central basin data collections. This master suite of forty-four maps represents a considerably broader geographic range within the basin. Additionally, three field seasons of data were compiled into the master suite of maps after the final editing of the Professional Paper. These maps are the culmination of Dr. Bown's Bighorn Basin research as a vertebrate paleontologist for the USGS. Data include Yale, Wyoming, Duke, Michigan and USGS localities. Practical topographic features are also indicated, such as jeep=trail access, new reservoirs, rerouted roadbeds, measured sections, fossil reconnaissance evaluations (G=good, NG=no good and H=hideous), faults, palcosol stages, and occasionally 'camp' vernacular for locality names.

  8. Forty-Fourth Annual Report of the National Advisory Committee for Aeronautics Administrative Report Including Technical Reports Nos. 1342 to 1392

    NASA Technical Reports Server (NTRS)

    1959-01-01

    In accordance with act of Congress, approved March 3, 1915, as amended (U.S.C., title 50, .sw 151), which established the National Advisory Committee for Aeronautics, the Committee submits its Forty-fourth Annual Report for the fiscal year 1958. This is the Committee's final report to the Congress. The National Aeronautics and Space Act of 1958 (Public Law 85-568) provides in section 301 that the NACA "shall cease to exist" and "all functions, powers, duties, and obligations, and all real and personal property, personnel (other than members of the Committee), funds, and records of the NACA shall be transferred to the National Aeronautics and Space Administration. The aforesaid act provides that "this section shall take effect 90 days after the date of the enactment of this act, or on any earlier date on which the Administrator shall determining and announce by proclamation published in the Federal Register, that the Administration has been organized and is prepared to discharge the duties and exercise the power conferred upon it by this act." The Administrator, Hon. T. Keith Glennan has advised the Committee of his intention to issue such proclamation, effective October 1,1958.

  9. Forty Years of Excellence and Beyond. Proceedings of the Annual North East Association for Institutional Research (NEAIR) Conference (40th, Newport, Rhode Island, November 9-12, 2013)

    ERIC Educational Resources Information Center

    Parker, Tiffany, Ed.

    2013-01-01

    The NEAIR 2013 Conference Proceedings is a compilation of papers presented at the Newport, Rhode Island, conference. Papers in this document include: (1) Aspiring to the Role of "Data Badass:" Some Thoughts on the Political Context of IR (Mark Freeman); (2) Data-Driven Internal Benchmarks and Successful Learning Outcomes (Mamta Saxena…

  10. [On Georges Canguilhem's "What does a scientific ideology mean?" and on French-German contributions on science and ideology in the last forty years].

    PubMed

    Debru, Claude

    2010-06-01

    This paper is based on Canguilhem's text on the concept of scientific ideology, which he introduced in 1969. We describe Canguilhem's attempts at designing a methodological framework for the history of science including the status of kinds of knowledge related to science, like scientific ideologies preceding particular scientific domains (like ideologies about inheritance before Mendel, or Spencer's universal evolutionary laws preceding Darwin). This attempt at picturing the relationships between science and ideology is compared with Jürgen Habermas's book Technology and Science as 'Ideology' in 1968. The philosphical issue of human normativity provides the framework of this discussion.

  11. Magma associations in Ediacaran granitoids of the Cachoeirinha‒Salgueiro and Alto Pajeú terranes, northeastern Brazil: Forty years of studies

    NASA Astrophysics Data System (ADS)

    Sial, Alcides N.; Ferreira, Valderez P.

    2016-07-01

    Granitic magmatism in the Cachoeirinha‒Salgueiro and Alto Pajeú terranes in the Transversal Zone Domain of the Borborema Province, northeastern Brazil, occurred in three main time intervals: 650-620 Ma, 590-560 Ma and 545-520 Ma. The oldest one is characterized by intrusions of magmatic-epidote (mEp) bearing calc-alkalic (some with trondhjemitic affinities) and high-K calc-alkalic plutons, synkinematic to the main regional foliation, under contractional tectonic regime, and exhibits TDM < 2.0 Ga and ƐNd (0.6 Ga) from -1 to -4, and δ18O (zircon) values from 7.1 to 10‰VSMOW. O- and Nd-isotope data for the 650‒620 Ma group of plutons is compatible with partial fusion of subducted oceanic basaltic crust (mEp-bearing calc-alkalic tonalites/granodiorites, equivalent to adakites). Voluminous intrusions in the 590-560 Ma interval are represented by abundant mEp-free high-K calc-alkalic, peralkalic, ultrapotassic, mEp-bearing high-K calc-alkalic, and less abundant shoshonitic magmas. Nd-model ages for this group of plutons vary from 1.5 to 2.5 Ga and ƐNd (0.6 Ga) ranges from -8 to -20; δ18O (zircon) varies from 6.4 to 7.9‰VSMOW. Values of δ18O (zircon) for the 590‒560 Ma old group of plutons coupled with Nd isotope data are compatible with remelting of crustal (negative ƐNd, 1.6 to 2.0 Ga old) source rocks. O- and Nd-isotope data for this group of plutons are compatible with underplating of basaltic magma in the base of the lower crust for the high-K calc-alkalic granitoids, coeval to transcurrent movements along sigmoidal shear zones. Intrusion of one shoshonitic (Serrote do Arapuá), one calc-alkalic (Riacho do Icó) plutons besides the peralkalic Manaíra-Princeza Isabel dike set have witnessed this transition from contractional to transcurrent movements along shear zones, around 610‒600 Ma.

  12. Disappearance of some human African trypanosomiasis transmission foci in Zambia in the absence of a tsetse fly and trypanosomiasis control program over a period of forty years.

    PubMed

    Mwanakasale, Victor; Songolo, Peter

    2011-03-01

    We conducted a situation analysis of human African trypanosomiasis (HAT) in Zambia from January 2000 to April 2007. The aim of this survey was to identify districts in Zambia that were still recording cases of HAT. Three districts namely, Mpika, Chama, and Chipata were found to be still reporting cases of HAT and thus lay in HAT transmission foci in North Eastern Zambia. During the period under review, 24 cases of HAT were reported from these three districts. We thereafter reviewed literature on the occurrence of HAT in Zambia from the early 1960s to mid 1990s. This revealed that HAT transmission foci were widespread in Western, North Western, Lusaka, Eastern, Luapula, and Northern Provinces of Zambia during this period. In this article we have tried to give possible reasons as to why the distribution of HAT transmission foci is so different between before and after 2000 when there has been no active national tsetse fly and trypanosomiasis control program in Zambia.

  13. Reshaping the All-Volunteer Force of the United States to Increase its Utility: A Reassessment of Over Forty Years of Experience

    DTIC Science & Technology

    2015-05-23

    and caused only limited US casualties. Operation ‘Desert Shield/Desert Storm’ has espe - cially been analyzed as the successful result of the...of the broad authori- ties President Bush requested and was allowed from a political and legal perspective see Gene Healy, “The Imperial Presidency...January 7, 2003), accessed January 25, 2015, http://iipdigital.usem- bassy.gov/st/ english /texttrans/2003/01/20030107160911sim- mons

  14. Forty years of the Institute for Nuclear Research (Scientific session of the Physical Sciences Division of the Russian Academy of Sciences, 22 December 2010)

    NASA Astrophysics Data System (ADS)

    2011-09-01

    On 22 December 2010, the scientific session of the Physical Sciences Division of the Russian Academy of Sciences (RAS), devoted to the 40th anniversary of the Institute for Nuclear Research, RAS, was held at the Institute for Nuclear Research, RAS in Troitsk. The agenda of the session announced on the website www.gpad.ac.ru of the RAS Physical Sciences Division listed the following reports: (1) Matveev V A (Institute for Nuclear Research, RAS, Moscow) "Introductory word"; (2) Gavrin V N (Institute for Nuclear Research, RAS, Moscow) "Contribution of the SAGE results to the understanding of solar physics and neutrino physics"; (3) Domogatsky G V (Institute for Nuclear Research, RAS, Moscow) "Baikal neutrino experiment"; (4) Tkachev I I (Institute for Nuclear Research, RAS, Moscow) "Observation of the Greisen - Zatsepin - Kuz'min effect at the Telescope Array Observatory"; (5) Kudenko Yu G (Institute for Nuclear Research, RAS, Moscow) "Neutrino T2K experiment: the first results"; (6) Sadykov R A (Institute for Nuclear Research, RAS, Moscow) "Fields of study of condensed media at the neutron facility at the INR, RAS"; (7) Zhuikov B L (Institute for Nuclear Research, RAS, Moscow) "Production of isotopes at the INR, RAS: reality and prospects".The papers written on the base of reports 1-5 and 7 are published below. In addition, the paper "High-power diode-pumped alkali lasers" by A M Shalagin is published. The paper is based on the report presented at the scientific session of the General Assembly of the Physical Sciences Division, RAS (13 December 2010) devoted to the 50th anniversary of the laser, the main materials of the session having been published in Usp. Fiz. Nauk 181 (8) 867 (2011) [Phys. Usp. 54 837 (2011)]. • Institute for Nuclear Research of the Russian Academy of Sciences turns 40, V A Matveev Physics-Uspekhi, 2011, Volume 54, Number 9, Pages 939-940 • The Russian-American gallium experiment SAGE, V N Gavrin Physics-Uspekhi, 2011, Volume 54, Number 9, Pages 941-949 • BAIKAL neutrino experiment, G V Domogatsky Physics-Uspekhi, 2011, Volume 54, Number 9, Pages 949-954 • Telescope Array Observatory observations of the Greisen-Zatsepin-Kuzmin effect, I I Tkachev Physics-Uspekhi, 2011, Volume 54, Number 9, Pages 954-961 • T2K neutrino experiment: first results, Yu G Kudenko Physics-Uspekhi, 2011, Volume 54, Number 9, Pages 961-968 • Isotope production at the Institute for Nuclear Research, Russian Academy of Sciences: current status and prospects, B L Zhuikov Physics-Uspekhi, 2011, Volume 54, Number 9, Pages 968-974

  15. Treatment of Failed Back Surgery Syndrome in a Forty-Three-Year-Old Man With High-Dose Oxycodone/Naloxone

    PubMed Central

    Bujedo, Borja Mugabure

    2015-01-01

    Introduction: Failed back surgery syndrome (FBSS) is an increasing cause of chronic pain in most countries. This poses high costs to both patients and National Health Organizations. Case Presentation: In this report, multimodal pain management based on daily high-dose oxycodone/naloxone (OXN 180/90 mg) led to reduced patient's pain score and improved quality of life. Conclusions: Oxycodone/naloxone can be a good alternative for the management of FBSS when other interventional or pharmacologic strategies have failed. In this case report, higher doses than those recommended as a maximum daily ceiling (80/40 mg) were safely used in one selected patient with noncancer severe pain. PMID:25893186

  16. Lessons from M 7.2 Seismic Event and How to Preserve Awareness Forty Years Later: The Case of the Vrancea, Romania, March 4, 1977 Earthquake

    NASA Astrophysics Data System (ADS)

    Craifaleanu, Iolanda-Gabriela; Georgescu, Emil-Sever; Dragomir, Claudiu-Sorin

    2016-10-01

    Almost four decades after the MG-R = 7.2 (Mw =7.4) catastrophic earthquake of March 4, 1977 hit Romania, the population fears a new strong earthquake; however, awareness on preparedness and mitigation measures is rather low. As the last Mw > 6 has occurred in 1990, there is an increasing percentage of young population that has not yet witnessed a strong earthquake, and which has a rather fuzzy representation of urban and geological earthquake effects. After each strong seismic event in the past, due to its specific attributions, the National Institute for Building Research, INCERC, collected a considerable amount of information about the earthquake effects on built environment and lifelines, geological effects etc. To this, information from various documentary sources about damage caused by historic earthquakes was added by the institute's specialists. Stored today in the archives of the National Institute for Research and Development in Construction, Urban Planning and Sustainable Spatial Development, “URBAN-INCERC”, INCERC Bucharest Branch, this information is invaluable today for evaluating the present and future seismic risk of the country. Nonetheless, it could represent an essential educational resource for university students and young professionals in the field of civil engineering, seismology, geology, economy, sociology, history etc. and for raising population awareness on seismic risk mitigation measures. The paper presents new approaches for the dissemination and re-valuation of the March 4, 1977 earthquake data, from the perspective of present scientific knowledge.

  17. Surgical Neurostimulation for Spinal Cord Injury

    PubMed Central

    Chari, Aswin; Hentall, Ian D.; Papadopoulos, Marios C.; Pereira, Erlick A. C.

    2017-01-01

    Traumatic spinal cord injury (SCI) is a devastating neurological condition characterized by a constellation of symptoms including paralysis, paraesthesia, pain, cardiovascular, bladder, bowel and sexual dysfunction. Current treatment for SCI involves acute resuscitation, aggressive rehabilitation and symptomatic treatment for complications. Despite the progress in scientific understanding, regenerative therapies are lacking. In this review, we outline the current state and future potential of invasive and non-invasive neuromodulation strategies including deep brain stimulation (DBS), spinal cord stimulation (SCS), motor cortex stimulation (MCS), transcutaneous direct current stimulation (tDCS) and repetitive transcranial magnetic stimulation (rTMS) in the context of SCI. We consider the ability of these therapies to address pain, sensorimotor symptoms and autonomic dysregulation associated with SCI. In addition to the potential to make important contributions to SCI treatment, neuromodulation has the added ability to contribute to our understanding of spinal cord neurobiology and the pathophysiology of SCI. PMID:28208601

  18. Optimization of return electrodes in neurostimulating arrays

    NASA Astrophysics Data System (ADS)

    Flores, Thomas; Goetz, Georges; Lei, Xin; Palanker, Daniel

    2016-06-01

    Objective. High resolution visual prostheses require dense stimulating arrays with localized inputs of individual electrodes. We study the electric field produced by multielectrode arrays in electrolyte to determine an optimal configuration of return electrodes and activation sequence. Approach. To determine the boundary conditions for computation of the electric field in electrolyte, we assessed current dynamics using an equivalent circuit of a multielectrode array with interleaved return electrodes. The electric field modeled with two different boundary conditions derived from the equivalent circuit was then compared to measurements of electric potential in electrolyte. To assess the effect of return electrode configuration on retinal stimulation, we transformed the computed electric fields into retinal response using a model of neural network-mediated stimulation. Main results. Electric currents at the capacitive electrode-electrolyte interface redistribute over time, so that boundary conditions transition from equipotential surfaces at the beginning of the pulse to uniform current density in steady state. Experimental measurements confirmed that, in steady state, the boundary condition corresponds to a uniform current density on electrode surfaces. Arrays with local return electrodes exhibit improved field confinement and can elicit stronger network-mediated retinal response compared to those with a common remote return. Connecting local return electrodes enhances the field penetration depth and allows reducing the return electrode area. Sequential activation of the pixels in large monopolar arrays reduces electrical cross-talk and improves the contrast in pattern stimulation. Significance. Accurate modeling of multielectrode arrays helps optimize the electrode configuration to maximize the spatial resolution, contrast and dynamic range of retinal prostheses.

  19. Effective Management of Trigeminal Neuralgia by Neurostimulation

    PubMed Central

    Abd-Elsayed, Alaa A.; Grandhi, Ravi; Sachdeva, Harsh

    2015-01-01

    Background Treatment of trigeminal neuralgia can be challenging for many physicians; patients who do not respond to conventional treatments and traditional surgical approaches often continue to suffer with pain. The peripheral nerve stimulator (PNS) has been used to treat many chronic pain conditions, but few reports exist about its use to treat trigeminal neuralgia. Case Report We present the case of a patient with trigeminal neuralgia resistant to conventional techniques of pain management. Conservative pain management was attempted but was ineffective. As a result, a PNS was placed with minimally invasive surgery. Pain scores were recorded before and after the procedure, and the patient reported complete resolution of her pain. Conclusion PNS implantation can be a safe and effective method to treat trigeminal neuralgia. More research is needed to define its mechanism of action. PMID:26130986

  20. The bromotyrosine derivative ianthelline isolated from the arctic marine sponge Stryphnus fortis inhibits marine micro- and macrobiofouling.

    PubMed

    Hanssen, Kine O; Cervin, Gunnar; Trepos, Rozenn; Petitbois, Julie; Haug, Tor; Hansen, Espen; Andersen, Jeanette H; Pavia, Henrik; Hellio, Claire; Svenson, Johan

    2014-12-01

    The inhibition of marine biofouling by the bromotyrosine derivative ianthelline, isolated from the Arctic marine sponge Stryphnus fortis, is described. All major stages of the fouling process are investigated. The effect of ianthelline on adhesion and growth of marine bacteria and microalgae is tested to investigate its influence on the initial microfouling process comparing with the known marine antifoulant barettin as a reference. Macrofouling is studied via barnacle (Balanus improvisus) settlement assays and blue mussel (Mytilus edulis) phenoloxidase inhibition. Ianthelline is shown to inhibit both marine micro- and macrofoulers with a pronounced effect on marine bacteria (minimum inhibitory concentration (MIC) values 0.1-10 μg/mL) and barnacle larval settlement (IC50 = 3.0 μg/mL). Moderate effects are recorded on M. edulis (IC50 = 45.2 μg/mL) and microalgae, where growth is more affected than surface adhesion. The effect of ianthelline is also investigated against human pathogenic bacteria. Ianthelline displayed low micromolar MIC values against several bacterial strains, both Gram positive and Gram negative, down to 2.5 μg/mL. In summary, the effect of ianthelline on 20 different representative marine antifouling organisms and seven human pathogenic bacterial strains is presented.

  1. 40 years of neutrino physics

    NASA Astrophysics Data System (ADS)

    Reines, Frederick

    Wolfgang Pauli and Enrico Fermi pioneered the hypothesis and characteristics of the weak interaction and the elementary particle called the neutrino. Since its discovery some forty years ago the neutrino has been shown to be a fundamental constituent of matter with a surprisingly rich, and in very many ways unexpected, set of characteristics ranging from basic roles in the generation of energy in the sun to supernovæ.

  2. 17 CFR 240.15a-4 - Forty-five day exemption from registration for certain members of national securities exchanges.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 3 2012-04-01 2012-04-01 false Forty-five day exemption from registration for certain members of national securities exchanges. 240.15a-4 Section 240.15a-4 Commodity and... national securities exchanges. (a) A natural person who is a member of a national securities exchange...

  3. 17 CFR 240.15a-4 - Forty-five day exemption from registration for certain members of national securities exchanges.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 3 2010-04-01 2010-04-01 false Forty-five day exemption from registration for certain members of national securities exchanges. 240.15a-4 Section 240.15a-4 Commodity and... national securities exchanges. (a) A natural person who is a member of a national securities exchange...

  4. 17 CFR 240.15a-4 - Forty-five day exemption from registration for certain members of national securities exchanges.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 4 2014-04-01 2014-04-01 false Forty-five day exemption from registration for certain members of national securities exchanges. 240.15a-4 Section 240.15a-4 Commodity and... national securities exchanges. (a) A natural person who is a member of a national securities exchange...

  5. 17 CFR 240.15a-4 - Forty-five day exemption from registration for certain members of national securities exchanges.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 3 2013-04-01 2013-04-01 false Forty-five day exemption from registration for certain members of national securities exchanges. 240.15a-4 Section 240.15a-4 Commodity and... national securities exchanges. (a) A natural person who is a member of a national securities exchange...

  6. 17 CFR 240.15a-4 - Forty-five day exemption from registration for certain members of national securities exchanges.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 3 2011-04-01 2011-04-01 false Forty-five day exemption from registration for certain members of national securities exchanges. 240.15a-4 Section 240.15a-4 Commodity and... national securities exchanges. (a) A natural person who is a member of a national securities exchange...

  7. Ocean Hill-Brownsville, 40 Years Later

    ERIC Educational Resources Information Center

    Kahlenberg, Richard D.

    2008-01-01

    Forty years ago--on May 9, 1968--the local school board in Brooklyn's black ghetto of Ocean Hill-Brownsville sent telegrams to 19 unionized educators, informing them that their employment in the district was terminated. Eighteen were white. One black teacher was mistakenly included on the list, but reinstated almost immediately after the error was…

  8. Puzzlemaking and Part-Whole Perception of Two-Year-Old and Four-Year-Old Children

    ERIC Educational Resources Information Center

    Montford, Emily I. Purvis; Readdick, Christine A.

    2008-01-01

    The relationship between preschoolers' puzzlemaking strategies and part-whole perception was investigated in the present study. Forty-eight two year olds and 48 four year olds were randomly selected from eight licensed childcare centers. Puzzlemaking strategies (image, form, color, and trial and error) were measured by performance in the…

  9. Forty-eight-inch lidar aerosol measurements taken at the Langley Research Center, May 1974 to December 1987

    NASA Technical Reports Server (NTRS)

    Fuller, W. H., Jr.; Osborn, M. T.; Hunt, W. H.

    1988-01-01

    A ground based lidar system located at NASA Langley Research Center in Hampton, Va., was used to obtain high resolution vertical profiles of the stratospheric and upper tropospheric aerosol since 1974. More than 200 measurements obtained at a wavelength of 0.6943 microns during 1974 to 1987 are summarized. Plots of peak backscatter mixing ratio and integrated backscatter vs time are presented for the entire measurement sequence. The plots highlight the influence of several major volcanic eruptions on the long term stratospheric aerosol layer. In particular, the eruptions of El Chichon in late Mar. to early Apr. 1982, produced a massive aerosol layer. Aerosol enhancement from El Chichon reached Hampton, Va. by May 1982, with a scattering ratio of approx. 50 detected on Jul. 1, 1982. In addition, scattering ratio profiles for June 1982 to December 1987, along with tables containing numerical values of the backscatter ratio and backscattering function versus altitude, are included to further describe the upper tropospheric and stratospheric aerosol layer. A 14 year summary is presented, in a ready to use format, of lidar observations at a fixed midlatitude location to be used for further study.

  10. Wide Field Lyman alpha Geocoronal Simulator (WFLaGS) for the Far-uv Off Rowland-circle Telescope for Imaging and Spectroscopy (FORTIS)

    NASA Astrophysics Data System (ADS)

    Carter, Anna; McCandliss, Stephan R.; Redwine, Keith; Pelton, Russell

    2017-01-01

    At 23:52 on 17 December 2015 FORTIS (36.312 UG) was launched from the White Sands Missile Range in New Mexico on a mission to observe hydrogen emission and absorption features superimposed on the stellar continua of hot star formation regions in the spiral galaxy NGC 1365. Unfortunately scattered geocoronal Lyα from well outside our nominal (1/2 degree)2 field-of-view (FOV) overwhelmed the signal from the target. Post-flight analysis of the observed scattered light levels, in comparison to a wide-FOV model of the light scattered from various surfaces in the optical train, produced good agreement. Suppression of this scatter is the highest priority for the FORTIS return to flight effort. Our analysis pointed to the need for development of a Wide Field Lyα Geocoronal Simulator (WFLaGS) with a 10○ FOV to fully characterize the end-to-end response of FORTIS to off-axis illumination. Previous end-to-end testing was performed with a vacuum UV collimator with only a limited FOV, ≈ 100”. The development of WFLaGS will allow us to validate our scattered light model and verify our mitigation strategies, which will incorporate low scatter materials, and possibly 3-d printed light traps, covering exposed scatter centers. The design of WFLaGs, consisting of a 50mm diameter F/1 aluminum parabolic collimator and a hydrogen discharge lamp with an ~ 80mm clear MgF2 window is described, along with our initial turn-on tests. This work is supported by NASA grants to John Hopkins University, NNX11AG54G and NNX14AI78G.

  11. Economic correlates of violent death rates in forty countries, 1962–2008: A cross-typological analysis

    PubMed Central

    Lee, Bandy X.; Marotta, Phillip L.; Blay-Tofey, Morkeh; Wang, Winnie; de Bourmont, Shalila

    2015-01-01

    Objectives Our goal was to identify if there might be advantages to combining two major public health concerns, i.e., homicides and suicides, in an analysis with well-established macro-level economic determinants, i.e., unemployment and inequality. Methods Mortality data, unemployment statistics, and inequality measures were obtained for 40 countries for the years 1962–2008. Rates of combined homicide and suicide, ratio of suicide to combined violent death, and ratio between homicide and suicide were graphed and analyzed. A fixed effects regression model was then performed for unemployment rates and Gini coefficients on homicide, suicide, and combined death rates. Results For a majority of nation states, suicide comprised a substantial proportion (mean 75.51%; range 0–99%) of the combined rate of homicide and suicide. When combined, a small but significant relationship emerged between logged Gini coefficient and combined death rates (0.0066, p < 0.05), suggesting that the combined rate improves the ability to detect a significant relationship when compared to either rate measurement alone. Results were duplicated by age group, whereby combining death rates into a single measure improved statistical power, provided that the association was strong. Conclusions Violent deaths, when combined, were associated with an increase in unemployment and an increase in Gini coefficient, creating a more robust variable. As the effects of macro-level factors (e.g., social and economic policies) on violent death rates in a population are shown to be more significant than those of micro-level influences (e.g., individual characteristics), these associations may be useful to discover. An expansion of socioeconomic variables and the inclusion of other forms of violence in future research could help elucidate long-term trends. PMID:26028985

  12. Phenylacetic Acid Is ISR Determinant Produced by Bacillus fortis IAGS162, Which Involves Extensive Re-modulation in Metabolomics of Tomato to Protect against Fusarium Wilt.

    PubMed

    Akram, Waheed; Anjum, Tehmina; Ali, Basharat

    2016-01-01

    Bacillus fortis IAGS162 has been previously shown to induce systemic resistance in tomato plants against Fusarium wilt disease. In the first phase of current study, the ISR determinant was isolated from extracellular metabolites of this bacterium. ISR bioassays combined with solvent extraction, column chromatography and GC/MS analysis proved that phenylacetic acid (PAA) was the potential ISR determinant that significantly ameliorated Fusarium wilt disease of tomato at concentrations of 0.1 and 1 mM. In the second phase, the biochemical basis of the induced systemic resistance (ISR) under influence of PAA was elucidated by performing non-targeted whole metabolomics through GC/MS analysis. Tomato plants were treated with PAA and fungal pathogen in various combinations. Exposure to PAA and subsequent pathogen challenge extensively re-modulated tomato metabolic networks along with defense related pathways. In addition, various phenylpropanoid precursors were significantly up-regulated in treatments receiving PAA. This work suggests that ISR elicitor released from B. fortis IAGS162 contributes to resistance against fungal pathogens through dynamic reprogramming of plant pathways that are functionally correlated with defense responses.

  13. Phenylacetic Acid Is ISR Determinant Produced by Bacillus fortis IAGS162, Which Involves Extensive Re-modulation in Metabolomics of Tomato to Protect against Fusarium Wilt

    PubMed Central

    Akram, Waheed; Anjum, Tehmina; Ali, Basharat

    2016-01-01

    Bacillus fortis IAGS162 has been previously shown to induce systemic resistance in tomato plants against Fusarium wilt disease. In the first phase of current study, the ISR determinant was isolated from extracellular metabolites of this bacterium. ISR bioassays combined with solvent extraction, column chromatography and GC/MS analysis proved that phenylacetic acid (PAA) was the potential ISR determinant that significantly ameliorated Fusarium wilt disease of tomato at concentrations of 0.1 and 1 mM. In the second phase, the biochemical basis of the induced systemic resistance (ISR) under influence of PAA was elucidated by performing non-targeted whole metabolomics through GC/MS analysis. Tomato plants were treated with PAA and fungal pathogen in various combinations. Exposure to PAA and subsequent pathogen challenge extensively re-modulated tomato metabolic networks along with defense related pathways. In addition, various phenylpropanoid precursors were significantly up-regulated in treatments receiving PAA. This work suggests that ISR elicitor released from B. fortis IAGS162 contributes to resistance against fungal pathogens through dynamic reprogramming of plant pathways that are functionally correlated with defense responses. PMID:27148321

  14. Frederick National Laboratory Celebrates 40 Years | Poster

    Cancer.gov

    By Ashley DeVine, Staff Writer Forty years ago, what we now call the Frederick National Laboratory for Cancer Research was born. Here are some highlights in the facility’s history. October 19, 1971 – President Richard Nixon announced that Fort Detrick would be converted from a biological warfare facility to a cancer research center (Covert, Norman M., Cutting Edge: A History of Fort Detrick, Maryland, 1943–1993, pp. 85–87).

  15. FNL: Marking the First 40 Years | Poster

    Cancer.gov

    By Carolynne Keenan, Guest Writer Forty years ago, a single act by former President Richard Nixon created what we now know as the Frederick National Laboratory for Cancer Research (FNL) at Fort Detrick. What began as a small facility with a staff of about 20 people in the early 1970s grew into the multi-facility, nationally distinguished laboratory for cancer research that it is today.

  16. A School and Home-Based Bilingual Education Model (Grades 3-6): End-of-Year Evaluation Report, 1979-80 (Fifth-Year Evaluation Study).

    ERIC Educational Resources Information Center

    Askins (B.E.) and Associates, Lubbock, TX.

    A Clovis, New Mexico, project designed to develop over five years a model English-Spanish bilingual program for limited English proficiency students from nursery school through grade 6 did not fully meet its objectives during the 1979-80 school year, the project's fifth and final year. One hundred forty students enrolled in grades 3-6 in two…

  17. Computing Trends in Small Liberal Arts Colleges: Ten Years Later.

    ERIC Educational Resources Information Center

    Smith, Peter

    Forty-one small liberal arts colleges were visited during the 1997-98 school year in order to talk to key information technology staff and to see computing facilities. A survey containing 15 factual and 10 open-ended questions was used to gather information. This paper presents findings in the following areas and comparison with results of a…

  18. Magic Memories: Young Children's Verbal Recall after a 6-Year Delay

    ERIC Educational Resources Information Center

    Jack, Fiona; Simcock, Gabrielle; Hayne, Harlene

    2012-01-01

    This report describes the first prospective study specifically designed to assess children's verbal memory for a unique event 6 years after it occurred. Forty-six 27- to 51-month-old children took part in a unique event and were interviewed about it twice, after 24-hr and 6-year delays. During the 6-year interview, 9 children verbally recalled the…

  19. The head of the finch: the anatomy of the feeding system in two species of finches (Geospiza fortis and Padda oryzivora).

    PubMed

    Genbrugge, Annelies; Herrel, Anthony; Boone, Matthieu; Van Hoorebeke, Luc; Podos, Jeffrey; Dirckx, Joris; Aerts, Peter; Dominique, Adriaens

    2011-12-01

    Despite the large number of studies devoted to the evolution of beak shape in Darwin's finches, surprisingly little is known about the morphology of the skull and jaw musculature in these birds. Moreover, it remains currently unclear whether Darwin's finches are unusual in their cranial morphology compared with other seed-cracking birds. Here, we provide a detailed description of the morphology of the cranial system in the medium ground finch (Geospiza fortis) and compare it with that of another seed-cracking bird of similar overall size and appearance, the Java finch (Padda oryzivora). Our data show an overall similarity in beak size and cranial morphology. Yet, differences in the jaw adductor size and corresponding attachments to the cranium and mandible are prominent, with the medium ground finch having much more robust jaw-closing muscles. This is reflected in differences in bite forces, with the medium ground finch biting much harder than the Java finch. These data suggest similarities in the evolution of the feeding system in birds specializing in the cracking of hard seeds, but also show the uniqueness of the cranial morphology and bite force of the medium ground finch compared with other seed-cracking birds.

  20. Horticultural therapy as a measure for recovery support of regional community in the disaster area: a preliminary experiment for forty five women who living certain region in the coastal area of Miyagi Prefecture.

    PubMed

    Kotozaki, Yuka

    2014-01-01

    Three years have passed since the earthquake, in the coastal areas in the disaster area, by population transfer or the like from the temporary housing, the importance of the regeneration and revitalization of the local community has been pointed out. This study performed a preliminary study to aim at the psychological inspection about an effect of the horticultural therapy as the means of the local community reproduction support of the disaster area. Forty five women who are living in the coastal area of Miyagi Prefecture participated in this study. They experienced the Great East Japan earthquake in 2011 and suffered some kind of damage caused by the earthquake. The participants were assigned to two groups, the intervention group and the control group, via a random draw using a computer. The HI group attended the horticultural therapy intervention (HT intervention) sessions for 16 weeks. The HT intervention was designed in collaboration with a horticultural therapist and clinical psychologists. This intervention comprised a total of 16 weekly sessions (120 min each) at the community center and 15 minutes per day at participants' homes. We used five psychological measures for an intervention evaluation. The HI group showed a significant increase in post- intervention SCI-2 total scores, post- intervention SCI-2 membership scores, post-intervention SCI-2 influence scores, post- intervention SCI-2 meeting needs scores, post- intervention SCI-2 shared emotional connection scores, and post- intervention RSES score. We believe that these results suggest the effectiveness of the horticultural therapy as the means of the local community reproduction.

  1. Experience-related reorganization of giant synapses in the lateral complex: Potential role in plasticity of the sky-compass pathway in the desert ant Cataglyphis fortis.

    PubMed

    Schmitt, Franziska; Stieb, Sara Mae; Wehner, Rüdiger; Rössler, Wolfgang

    2016-04-01

    Cataglyphis desert ants undergo an age-related polyethism from interior workers to relatively short-lived foragers with remarkable visual navigation capabilities, predominantly achieved by path integration using a polarized skylight-based sun compass and a stride-integrating odometer. Behavioral and physiological experiments revealed that the polarization (POL) pattern is processed via specialized UV-photoreceptors in the dorsal rim area of the compound eye and POL sensitive optic lobe neurons. Further information about the neuronal substrate for processing of POL information in the ant brain has remained elusive. This work focuses on the lateral complex (LX), known as an important relay station in the insect sky-compass pathway. Neuroanatomical results in Cataglyphis fortis show that LX giant synapses (GS) connect large presynaptic terminals from anterior optic tubercle neurons with postsynaptic GABAergic profiles of tangential neurons innervating the ellipsoid body of the central complex. At the ultrastructural level, the cup-shaped presynaptic structures comprise many active zones contacting numerous small postsynaptic profiles. Three-dimensional quantification demonstrated a significantly higher number of GS (∼ 13%) in foragers compared with interior workers. Light exposure, as opposed to age, was necessary and sufficient to trigger a similar increase in GS numbers. Furthermore, the increase in GS numbers was sensitive to the exclusion of UV light. As previous experiments have demonstrated the importance of the UV spectrum for sky-compass navigation in Cataglyphis, we conclude that plasticity in LX GS may reflect processes involved in the initial calibration of sky-compass neuronal circuits during orientation walks preceding active foraging.

  2. Commitment to the Core: A Longitudinal Analysis of Humanities Degree Production in Four-Year Colleges

    ERIC Educational Resources Information Center

    Hearn, James C.; Belasco, Andrew S.

    2015-01-01

    As many national commissions and observers have noted, the past forty years have brought unprecedented declines in humanities enrollments and programs in U.S. higher education. These changes are particularly striking in the iconic academic heart of the enterprise, the four-year college sector, where many institutions have diversified curricular…

  3. Where "Sign Language Studies" Has Led Us in Forty Years: Opening High School and University Education for Deaf People in Viet Nam through Sign Language Analysis, Teaching, and Interpretation

    ERIC Educational Resources Information Center

    Woodward, James; Hoa, Nguyen Thi

    2012-01-01

    This paper discusses how the Nippon Foundation-funded project "Opening University Education to Deaf People in Viet Nam through Sign Language Analysis, Teaching, and Interpretation," also known as the Dong Nai Deaf Education Project, has been implemented through sign language studies from 2000 through 2012. This project has provided deaf…

  4. A survey of the spider family Nesticidae (Arachnida, Araneae) in Asia and Madagascar, with the description of forty-three new species

    PubMed Central

    Lin, Yucheng; Ballarin, Francesco; Li, Shuqiang

    2016-01-01

    Abstract Forty-three new species of Nesticidae are described from China, Indonesia, Philippines, Singapore, Thailand, Vietnam and Madagascar, and two new junior synonyms are suggested. A new genus, Speleoticus gen. n., is described with Nesticus navicellatus Liu & Li, 2013 as the type species, and four species are transferfed from Nesticus, i.e., Speleoticus globosus (Liu & Li, 2013), comb. n., Speleoticus libo (Chen & Zhu, 2005), comb. n., Speleoticus navicellatus (Liu & Li, 2015), comb. n. and Speleoticus uenoi (Yaginuma, 1972), comb. n. The new species described in this paper belong to four genera and are: Hamus cornutus sp. n. (♂♀), Hamus kangdingensis sp. n. (♂), Hamus luzon sp. n. (♀), Hamus mangunensis sp. n. (♂), Nescina kohi sp. n. (♂♀), Nesticella baiseensis sp. n. (♂♀), Nesticella baobab sp. n. (♂), Nesticella caeca sp. n. (♂♀), Nesticella chongqing sp. n. (♀), Nesticella dazhuangensis sp. n. (♂♀), Nesticella fuliangensis sp. n. (♂♀), Nesticella gazuida sp. n. (♀), Nesticella gongshanensis sp. n. (♀), Nesticella griswoldi sp. n. (♂♀), Nesticella hongheensis sp. n. (♂♀), Nesticella huomachongensis sp. n. (♂♀), Nesticella jingpo sp. n. (♀), Nesticella kaohsiungensis sp. n. (♂♀), Nesticella lisu sp. n. (♂♀), Nesticella liuzhaiensis sp. n. (♀), Nesticella nandanensis sp. n. (♂♀), Nesticella phami sp. n. (♂♀), Nesticella potala sp. n. (♀), Nesticella qiaoqiensis sp. n. (♀), Nesticella qiongensis sp. n. (♂♀), Nesticella robusta sp. n. (♂♀), Nesticella rongtangensis sp. n. (♂), Nesticella sanchaheensis sp. n. (♂♀), Nesticella sulawesi sp. n. (♀), Nesticella sumatrana sp. n. (♂), Nesticella tibetana sp. n. (♂♀), Nesticella vanlang sp. n. (♀), Nesticella wanzaiensis sp. n. (♂♀), Nesticella xiongmao sp. n. (♂♀), Nesticella xixia sp. n. (♂♀), Nesticella yanbeiensis sp. n. (♂♀), Nesticella yao sp. n. (♀), Nesticella zhiyuani sp. n. (

  5. Laser patterning of platinum electrodes for safe neurostimulation

    NASA Astrophysics Data System (ADS)

    Green, R. A.; Matteucci, P. B.; Dodds, C. W. D.; Palmer, J.; Dueck, W. F.; Hassarati, R. T.; Byrnes-Preston, P. J.; Lovell, N. H.; Suaning, G. J.

    2014-10-01

    Objective. Laser surface modification of platinum (Pt) electrodes was investigated for use in neuroprosthetics. Surface modification was applied to increase the surface area of the electrode and improve its ability to transfer charge within safe electrochemical stimulation limits. Approach. Electrode arrays were laser micromachined to produce Pt electrodes with smooth surfaces, which were then modified with four laser patterning techniques to produce surface structures which were nanosecond patterned, square profile, triangular profile and roughened on the micron scale through structured laser interference patterning (SLIP). Improvements in charge transfer were shown through electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV) and biphasic stimulation at clinically relevant levels. A new method was investigated and validated which enabled the assessment of in vivo electrochemically safe charge injection limits. Main results. All of the modified surfaces provided electrical advantage over the smooth Pt. The SLIP surface provided the greatest benefit both in vitro and in vivo, and this surface was the only type which had injection limits above the threshold for neural stimulation, at a level shown to produce a response in the feline visual cortex when using an electrode array implanted in the suprachoroidal space of the eye. This surface was found to be stable when stimulated with more than 150 million clinically relevant pulses in physiological saline. Significance. Critical to the assessment of implant devices is accurate determination of safe usage limits in an in vivo environment. Laser patterning, in particular SLIP, is a superior technique for improving the performance of implant electrodes without altering the interfacial electrode chemistry through coating. Future work will require chronic in vivo assessment of these electrode patterns.

  6. A Hermetic Wireless Subretinal Neurostimulator for Vision Prostheses

    PubMed Central

    Shire, Douglas B.; Chen, Jinghua; Doyle, Patrick; Gingerich, Marcus D.; Cogan, Stuart F.; Drohan, William A.; Behan, Sonny; Theogarajan, Luke; Wyatt, John L.; Rizzo, Joseph F.

    2016-01-01

    A miniaturized, hermetically encased, wirelessly operated retinal prosthesis has been developed for preclinical studies in the Yucatan minipig, and includes several design improvements over our previously reported device. The prosthesis attaches conformally to the outside of the eye and electrically drives a microfabricated thin-film polyimide array of sputtered iridium oxide film electrodes. This array is implanted into the subretinal space using a customized ab externo surgical technique. The implanted device includes a hermetic titanium case containing a 15-channel stimulator chip and discrete circuit components. Feedthroughs in the case connect the stimulator chip to secondary power and data receiving coils on the eye and to the electrode array under the retina. Long-term in vitro pulse testing of the electrodes projected a lifetime consistent with typical devices in industry. The final assembly was tested in vitro to verify wireless operation of the system in physiological saline using a custom RF transmitter and primary coils. Stimulation pulse strength, duration, and frequency were programmed wirelessly from a Peripheral Component Interconnect eXtensions for Instrumentation (PXI) computer. Operation of the retinal implant has been verified in two pigs for up to five and a half months by detecting stimulus artifacts generated by the implanted device. PMID:21859595

  7. [Transcranial direct current stimulation: a new tool for neurostimulation].

    PubMed

    Thibaut, A; Chatelle, C; Gosseries, O; Laureys, S; Bruno, M-A

    2013-02-01

    Transcranial direct current stimulation (tDCS) is a safe method to modulate cortical excitability. Anodal stimulation can improve the stimulated area's functions whereas cathodal stimulation reduces them. Currently, a lot of clinical trials have been conducted to study the effect of tDCS on post-stroke motor and language deficits, in depression, chronic pain, memory impairment and tinnitus in order to decrease symptoms. Results showed that, if an effect is observed with tDCS, it does not persist over time. Current studies suggest that direct current stimulation is a promising technique that helps to improve rehabilitation after stroke, to enhance cognitive deficiencies, to reduce depression and to relieve chronic pain. Moreover, it is a safe, simple and cheap device that could be easily integrated in a rehabilitation program.

  8. Cognitive Neurostimulation: Learning to Volitionally Sustain Ventral Tegmental Area Activation.

    PubMed

    MacInnes, Jeff J; Dickerson, Kathryn C; Chen, Nan-kuei; Adcock, R Alison

    2016-03-16

    Activation of the ventral tegmental area (VTA) and mesolimbic networks is essential to motivation, performance, and learning. Humans routinely attempt to motivate themselves, with unclear efficacy or impact on VTA networks. Using fMRI, we found untrained participants' motivational strategies failed to consistently activate VTA. After real-time VTA neurofeedback training, however, participants volitionally induced VTA activation without external aids, relative to baseline, Pre-test, and control groups. VTA self-activation was accompanied by increased mesolimbic network connectivity. Among two comparison groups (no neurofeedback, false neurofeedback) and an alternate neurofeedback group (nucleus accumbens), none sustained activation in target regions of interest nor increased VTA functional connectivity. The results comprise two novel demonstrations: learning and generalization after VTA neurofeedback training and the ability to sustain VTA activation without external reward or reward cues. These findings suggest theoretical alignment of ideas about motivation and midbrain physiology and the potential for generalizable interventions to improve performance and learning.

  9. Ferrite core non-linearity in coils for magnetic neurostimulation.

    PubMed

    RamRakhyani, Anil Kumar; Lazzi, Gianluca

    2014-10-01

    The need to correctly predict the voltage across terminals of mm-sized coils, with ferrite core, to be employed for magnetic stimulation of the peripheral neural system is the motivation for this work. In such applications, which rely on a capacitive discharge on the coil to realise a transient voltage curve of duration and strength suitable for neural stimulation, the correct modelling of the non-linearity of the ferrite core is critical. A demonstration of how a finite-difference model of the considered coils, which include a model of the current-controlled inductance in the coil, can be used to correctly predict the time-domain voltage waveforms across the terminals of a test coil is presented. Five coils of different dimensions, loaded with ferrite cores, have been fabricated and tested: the measured magnitude and width of the induced pulse are within 10% of simulated values.

  10. Revision of the Agathidinae (Hymenoptera, Braconidae) of Vietnam, with the description of forty-two new species and three new genera

    PubMed Central

    van Achterberg, Cornelis; Long, Khuat Dang

    2010-01-01

    Abstract The species of seventeen genera of Agathidinae (Braconidae) from Vietnam are revised: Agathis Latreille, 1804, Bassus Fabricius, 1804; Biroia Szépligeti, 1900; Braunsia Kriechbaumer, 1894; Camptothlipsis Enderlein, 1920; Coccygidium de Saussure, 1892; Coronagathis gen. n. (type species: Coronagathis cornifera sp. n.); Cremnops Foerster, 1862; Disophrys Foerster, 1862; Earinus Wesmael, 1837; Euagathis Szépligeti, 1900; Gyragathis gen. n. (type species: Gyragathis quyi sp. n.), Gyrochus Enderlein, 1920; Lytopylus Foerster, 1862; Therophilus Wesmael, 1837; Troticus Brullé, 1846, and Zelodia gen. n. (type species: Zelomorpha varipes van Achterberg & Maetô, 1990). Keys to the Vietnamese species are given. Sixty-five species are recognised, of which twelve species are newly recorded for Vietnam: Bassus albifasciatus (Watanabe, 1934), Coccygidium angostura (Bhat & Gupta, 1977), Cremnops atricornis (Smith, 1874), stat. n., Disophrys erythrocephala Cameron, 1900, Gyrochus yunnanensis Wang, 1984, Lytopylus romani (Shestakov, 1940), comb. n., Therophilus festivus (Muesebeck, 1953), comb. n., Therophilus javanus (Bhat & Gupta, 1977), comb. n., Therophilus lienhuachihensis (Chou & Sharkey, 1989), comb. n., Therophilus marshi (Bhat & Gupta, 1977), comb. n., Zelodia absoluta (Chen & Yang, 1998), comb. n. and Zelodia longidorsata (Bhat & Gupta, 1977), comb. n. Forty-two species are new to science: Agathis citrinisoma sp. n., Bassus albobasalis sp. n., Bassus albozonatus sp. n., Biroia soror sp. n., Braunsia bicolorata sp. n., Braunsia devriesi sp. n., Braunsia maculifera sp. n., Braunsia nigrapiculata sp. n., Braunsia pumatica sp. n., Camptothlipsis hanoiensis sp. n., Coronagathis cornifera sp. n., Earinus aurantius sp. n., Earinus brevistigmus sp. n., Euagathis flavosoma sp. n., Disophrys maculifera sp. n., Disophrys quymanhi sp. n., Disophrys rhinoides sp. n., Gyragathis quyi sp. n., Therophilus annuliferus sp. n., Therophilus cattienensis sp. n., Therophilus

  11. The Economic Benefits of Reducing the Dropout Rate for Students of Color in the Nation's Forty-Five Largest Metropolitan Areas. Summary of Findings

    ERIC Educational Resources Information Center

    Alliance for Excellent Education, 2010

    2010-01-01

    Years of data have consistently underscored the persistent graduation gap between America's students of color and their peers. The most recent estimate shows that high school graduation rates for African American, Latino, and American Indian students hover only slightly higher than 50 percent. This is more than 20 percentage points lower than that…

  12. A Century of Change: The History of Two-Year Education in the State of Alabama, 1866-1963

    ERIC Educational Resources Information Center

    Smith, Dustin P.

    2012-01-01

    Much has been written about two-year education in Alabama during the governorships of George C. Wallace, but little about two-year education prior to his first inauguration in 1963. Yet nearly a third of the forty-three junior, technical, and community college institutions that eventually formed the Alabama Community College System had been…

  13. Past Years

    NASA Astrophysics Data System (ADS)

    Lodge, Oliver

    2012-07-01

    Preface; 1. Ancestry and early days; 2. Schooldays; 3. Relation with other boys at school; 4. Education; 5. Influence of the Royal Institution; 6. Later education in London; 7. Reminiscences of Bedford College; 8. Scientific work and friends in London; 9. Personal retrospect; 10. Romance; 11. Influence of the British Association; 12. Reminiscences of Coopers Hill and assistants and popular lectures; 13. Liverpool; 14. Scientific work at Liverpool; 15. Scientific work at Liverpool (cont.); 16. Scientific work at Liverpool (cont.); 17. Electric waves and the beginnings of wireless; 18. Other friends; 19. Family life; 20. Holidays; 21. Side issues; 22. Early experiences in psychical research; 23. Psychical research; 24. Further psychic adventures, and psycho-physical phenomena; 25. Reminiscences of my years at the university of Birmingham; 26. Birmingham friendships and recollections; 27. Scientific retrospect; 28. Apologia pro vita mea; Index.

  14. Integrating Geographic Information Systems and Remote Sensing for Technical Workforce Training at Two-Year Colleges

    ERIC Educational Resources Information Center

    National Council for Geographic Education (NJ1), 2006

    2006-01-01

    This report examines the outcomes of a workshop held at the National Science Foundation on August 15-16, 2005. Forty-six participants, representing academia, industry, government agencies, professional associations, and special projects met to: (1) discuss how geospatial technology training at two-year colleges can address workforce needs; and…

  15. Dropped into the Deep End: A Study of Personal Journals in First-Year Composition

    ERIC Educational Resources Information Center

    Wester, Jason Michael

    2012-01-01

    This study investigated the lived experiences of first-year college students who kept personal and private journals in an English composition course. The purpose of this study was to provide a description of the lived experiences of keeping those journals from the point-of-view of the journal writers themselves. Forty-eight students were involved…

  16. Alienation and First-Year Student Retention. Professional File. Number 116, Spring 2010

    ERIC Educational Resources Information Center

    Liu, Richard

    2010-01-01

    Since Summerskill's study on college attrition forty years ago, the interest in this topic has never waned. This study was particularly interested in the relationship of race to retention. Various theoretical frames of references have been proposed: Price's organization theory, Durkheim's Suicide, and Marx's Alienation have been used to guide…

  17. Emotional and Personality-Related Career Decision-Making Difficulties: A 3-Year Follow-Up

    ERIC Educational Resources Information Center

    Gati, Itamar; Asulin-Peretz, Lisa; Fisher, Ahinoam

    2012-01-01

    This study tests the temporal stability and the concurrent and predictive validity of the Emotional and Personality-related Career decision-making Difficulties (EPCD) model and questionnaire. Five hundred forty-three participants filled out the EPCD twice, 3 years apart. The Anxiety cluster was the most stable of the three, followed by the…

  18. Adult Learner Perceptions: Perspectives from Beginning Musicians (Ages 60-86 Years)

    ERIC Educational Resources Information Center

    Bugos, Jennifer A.

    2014-01-01

    The purpose of this project was to examine adult learning perceptions of a model music program with group piano instruction and group percussion ensemble for beginning-level musicians (ages 60-86 years). Participants were matched by age and education to two 16-week music programs. Forty participants completed a post-training questionnaire related…

  19. A Study of First-Year Chemistry Students' Understanding of Solution Concentration at the Tertiary Level

    ERIC Educational Resources Information Center

    de Berg, Kevin

    2012-01-01

    This paper reports on students' understanding of sugar concentration in aqueous solutions presented in two different modes: a visual submicroscopic mode for particles and a verbal mode referring to macroscopic amounts of sugar. One hundred and forty-five tertiary college students studying some form of first-year chemistry participated in the…

  20. The Effect of Priming on Referential Communication in Four Year Olds.

    ERIC Educational Resources Information Center

    Foorman, Barbara R.

    A study was conducted in light of a neo-Piagetian theory of cognitive development to interpret the effect of priming executive schemes for describing relevant features in a referential communication task. Forty-eight 4-year-old children were divided into primed and nonprimed groups and were asked to describe in isolation a black and white…

  1. Treatment of fulminant hepatic failure with infusions of Co-factors and mannitol and charcoal-hemoperfusions during Forty-one days.

    PubMed

    Thölen, H; Bianchi, L; Ulrich, J; Heierli, C; Ritz, R

    1979-09-17

    The clinical course of a 26 year old female patient with acute liver necrosis and coma due to hepatitis B is reported. The disturbances of conciousness had improved. The patient survived 41 days after the beginning of the coma and developed liver cell regeneration and an acute post-hepatitic liver cirrhosis. As a grave complication a septicemia with aspergillus was observed. The patient died because of gastro-intestinal hemorrhage. At autopsy there were no signs of brain edema. The treatment consisted in: daily infusions with coenzyme A, nicotinamid-adenin-dinucleotide, alpha lipoic acid and cocarboxylase to improve the metabolic disorders and the clinical picture; mannitol intravenously to prevent and to treat cerebral edema; 33 charcoal-hemoperfusions to remove toxic substances of acute liver failure. Treatment of the aspergillus infection with 5-fluorocytosine and amphotericine B and infusion of concentrated ascites led to a decompensation of liver functions. From this observation the following conclusions can be drawn: after an acute viral hepatic necrosis, new synthetic functions and improvements of the disturbed intermediary metabolism in regenerated liver-cells can eventually be seen only after twenty-four to thirty days. With systematically applicated mannitol infusions it is possible to treat cerebral edema effectively.

  2. Partnering To Build a Quality Workforce: Critical Issues in Environmental Technology Education at Two-Year Colleges. A Report of the National Forum on Critical Issues in Environmental Technology Education at Two-Year Colleges (Washington, D.C., March 2-4, 1995).

    ERIC Educational Resources Information Center

    Kabat, Ellen J.; Friedel, Janice Nahra; Senew, Mike

    The National Forum on Critical Issues in Environmental Technology Education at Two-Year Colleges addressed critical issues relevant to environmental technology education in the United States. Forty-three participants from across the country who attended the 1995 Forum represented business and industry, two-year colleges, four-year colleges and…

  3. 40 year retrospective of fundamental mechanisms

    NASA Astrophysics Data System (ADS)

    Soileau, M. J.

    2008-10-01

    Fundamental mechanisms of laser induced damage (LID) have been one of the most controversial topics during the forty years of the Boulder Damage Symposium (Ref. 1.) LID is fundamentally a very nonlinear process and sensitive to a variety of parameters including wavelength, pulse width, spot size, focal conditions, material band gap, thermal-mechanical prosperities, and component design considerations. The complex interplay of many of these parameters and sample to sample materials variations combine to make detailed, first principle, models very problematic at best. The phenomenon of self-focusing, the multi spatial and temporal mode structure of most lasers, and the fact that samples are 'consumed' in testing complicate experiential results. This paper presents a retrospective of the work presented at this meeting.

  4. Learning, Engagement, and Technology: Middle School Students' Three-Year Experience in Pervasive Technology Environments in South Korea

    ERIC Educational Resources Information Center

    Hur, Jung Won; Oh, Jaekyeon

    2012-01-01

    This study explored an initiative that created a pervasive learning environment in a middle school in South Korea and examined its impact on student academic achievement and learning engagement. Forty students received a laptop to use for class projects, online collaboration, and lesson reviews over a 3-year period. To measure the effect of laptop…

  5. "No Shoes; They Walked Away?": Effects of Enhancements on Learning and Using Blissymbols by Normal 3-Year-Old Children.

    ERIC Educational Resources Information Center

    Raghavendra, Parimala; Fristoe, Macalyne

    1995-01-01

    Forty 3-year-olds learned either 12 standard Blissymbols (SBS) or their enhanced forms (EBS). Results demonstrated that the subjects learned EBS faster than SBS, remembered more EBS than SBS, did not differ in the communicative use of SBS and EBS, and were affected more negatively when presented with the untrained SBS than EBS. (Author/JDD)

  6. A Meta-Analysis Examining the Impact of Computer-Assisted Instruction on Postsecondary Statistics Education: 40 Years of Research

    ERIC Educational Resources Information Center

    Larwin, Karen; Larwin, David

    2011-01-01

    The present meta-analysis is a comprehensive investigation of the effectiveness of computer-assisted instruction (CAI) on student achievement in postsecondary statistics education across a forty year period of time. The researchers calculated an overall effect size of 0.566 from 70 studies, for a total of 219 effect-size measures from a sample of…

  7. 15 Years of Terra, 14 Years of Application Usage

    NASA Astrophysics Data System (ADS)

    Schmaltz, J. E.; Alarcon, C.; Boller, R. A.; Cechini, M. F.; Davies, D.; Fu, G.; Gunnoe, T.; Hall, J. R.; Huang, T.; Ilavajhala, S.; Jackson, M.; King, J.; McGann, M.; Murphy, K. J.; Roberts, J. T.; Thompson, C. K.; Ye, G.

    2014-12-01

    The instruments onboard the Terra spacecraft were designed for long-term Earth science research but not long after launch it became apparent that this data and imagery could be made available in near real-time for applications users. During the year 2000 fire season in the western United States, the US Forest Service approached NASA with a request to expedite MODIS fire detections. The Rapid Response system was created to generate fire detections as well as true color imagery in both swath and geo-referenced formats. This imagery was used by a wide variety of applications, such as NASA's AERONET program, the USDA Foreign Agricultural Service, Antarctic resupply shipping, flood mapping for relief agencies, Deepwater Horizon monitoring, volcanic ash monitoring, as well as print, televised, and Internet media. From 2004, the University of Maryland's Web Fire Mapper helped distribute fire detection information in a variety of formats. However, the applications community expressed the need for near-real time access to the underlying data. This requirement led to the development of the Land Atmosphere Near real-time Capability for EOS (Earth Observing System) (LANCE) in 2009. To achieve the latency requirements, many components of the EOS satellite operations, ground and science processing systems had to be made more efficient. In addition, products that require ancillary data were modified to use alternate inputs. Forty Terra MODIS data products are currently available from LANCE. LANCE also includes data from other instruments including AIRS, AMSR-E, MLS, and OMI. To help near-real time users navigate this large data offering, a new imagery service was begun in 2011 - Global Imagery Browse Services (GIBS). This service provides very responsive viewing using the Web Map Tile Service protocol. These programs will continue to support and expand the use of Terra data for near-real time applications well into the future.

  8. TESOL at Forty: What Are the Issues?

    ERIC Educational Resources Information Center

    Canagarajah, A. Suresh

    2006-01-01

    This overview delineates the direction of pedagogical developments since the 25th anniversary issue of "TESOL Quarterly." Three tendencies characterize our professional practice: (a) a continuation along the earlier lines of progression (i.e., in opening up the classroom to learning opportunities, integrating skills, and teaching for specific…

  9. Forty Targets of the Textbook Protesters.

    ERIC Educational Resources Information Center

    Jenkinson, Edward B.

    This paper gives a brief history of the Reverend Jerry Falwell's Moral Majority campaign against humanism in public school education. The document describes the successful textbook evaluation strategies of Mel and Norma Gabler of Texas, on which Dr. Falwell relies heavily, and lists 20 organizations protesting textbooks, library books, and…

  10. Forty Meters from Entry to Victoria Crater

    NASA Technical Reports Server (NTRS)

    2007-01-01

    NASA's Mars Exploration Rover Opportunity used its navigation camera during the rover's 1,278th Martian day, or sol, (Aug. 28, 2007) to take the images combined into this view. The rover was perched at the lip of Victoria Crater, which is about 800 meters (one-half mile) in diameter.

    After assessment of possible routes for Opportunity to descend into the crater, the rover team selected a site farther to the right along the rim. That selected entry point lies near the ripple of bright soil visible just outside the crater near the top center of this scene. The driving distance for Opportunity from the Sol 1,278 viewpoint to the selected entry point is about 40 meters (about 130 feet).

    This view is presented as a cylindrical projection with geometric seam correction.

  11. Remodeling of tibial fractures in children younger than 12 years.

    PubMed

    Dwyer, Amitabh Jitendra; John, Bobby; Krishen, Maharaj; Hora, Rajeev

    2007-05-01

    Forty-eight children with an average age of 7.2 years (range: 3-12 years) were examined clinically and radiographically at an average 4-year follow-up (range: 2-10 years), between 1989 and 2000 to analyze correction of deformities following tibial shaft fractures. An inconsistent alteration in the length of the fractured tibia was observed. Anterior angular deformity realigned maximally (52.7%) followed by varus (40.9%) and valgus (23.9%) deformities. Posterior deformity corrected the least (18.5%). In the sagittal plane, acceptable critical anterior and posterior angular deformities that corrected completely were 12 degrees and 6 degrees respectively. In the coronal plane, acceptable critical angular deformities were 10 degrees varus and 8 degrees valgus.

  12. Normative Data for the Words-in-Noise Test for 6- to 12-Year-Old Children

    ERIC Educational Resources Information Center

    Wilson, Richard H.; Farmer, Nicole M.; Gandhi, Avni; Shelburne, Emily; Weaver, Jamie

    2010-01-01

    Purpose: To establish normative data for children on the Words-in-Noise Test (WIN; R. H. Wilson, 2003; R. H. Wilson & R. McArdle, 2007). Method: Forty-two children in each of 7 age groups, ranging in age from 6 to 12 years (n = 294), and 24 young adults (age range: 18-27 years) with normal hearing for pure tones participated. All listeners…

  13. Looking Forward to the Year 2000: Public Policy and Philanthropy. Working Papers, Spring Research Forum (San Francisco, California, March 17-18, 1988).

    ERIC Educational Resources Information Center

    Independent Sector, Washington, DC.

    Forty-six working papers for presentation at a research forum on public policy and philanthropy are presented. Thirteen sections include the following topics: (1) looking forward to the year 2000: public policy and philanthropy (e.g. "Rationales for Tax Exemption," by Harvey P. Dale); (2) shifting boundaries among the sectors (e.g. "The Shifting…

  14. The Socio-Cultural and Leadership Experiences of Latina Four-Year College and University Presidents: A Traves de sus Voces (Through Their Voices)

    ERIC Educational Resources Information Center

    Maes, Johanna B.

    2012-01-01

    The Latina population in the United States is one of the largest of all racial and ethnic groups, and it is expected to grow exponentially within the next forty years. Despite these large numbers of Latinas in the U.S., there is a disparity with this population who are leading our nation's four-year colleges and universities. A reason for…

  15. Electrical brain stimulation for epilepsy.

    PubMed

    Fisher, Robert S; Velasco, Ana Luisa

    2014-05-01

    Neurostimulation enables adjustable and reversible modulation of disease symptoms, including those of epilepsy. Two types of brain neuromodulation, comprising anterior thalamic deep brain stimulation and responsive neurostimulation at seizure foci, are supported by Class I evidence of effectiveness, and many other sites in the brain have been targeted in small trials of neurostimulation therapy for seizures. Animal studies have mainly assisted in the identification of potential neurostimulation sites and parameters, but much of the clinical work is only loosely based on fundamental principles derived from the laboratory, and the mechanisms by which brain neurostimulation reduces seizures remain poorly understood. The benefits of stimulation tend to increase over time, with maximal effect seen typically 1-2 years after implantation. Typical reductions of seizure frequency are approximately 40% acutely, and 50-69% after several years. Seizure intensity might also be reduced. Complications from brain neurostimulation are mainly associated with the implantation procedure and hardware, including stimulation-related paraesthesias, stimulation-site infections, electrode mistargeting and, in some patients, triggered seizures or even status epilepticus. Further preclinical and clinical experience with brain stimulation surgery should lead to improved outcomes by increasing our understanding of the optimal surgical candidates, sites and parameters.

  16. Celebrating 50 Years!

    ERIC Educational Resources Information Center

    Kristjansdottir, Anna

    2011-01-01

    The author congratulates members of the Association of Teachers of Mathematics (ATM) on celebrating the 50th anniversary of their annual conference. These conferences have kept the spirit alive from the early years, especially the engagement in investigative, collaborative, and reasoning activities. In the 50th year as an association, the author…

  17. Year-Round School.

    ERIC Educational Resources Information Center

    Tiffany, Burton C.

    This presentation describes the year-round school operation of the Chula Vista City School District in California. Chula Vista adopted the 45-15 year-round plan to help ease a shortage of classroom space while maintaining a quality program for children. Under the plan, each pupil attends school for about nine weeks and then has vacation for three…

  18. 20 Years and Counting

    ERIC Educational Resources Information Center

    Kuzyk, Raya

    2008-01-01

    In commemoration of the Librarian of the Year Award's 20th anniversary, this article presents brief vignettes on all 19 of the title holders. When "Library Journal" named them Librarians of the Year, these inimitable 19 (for the 20th, Norma Blake, see EJ788676) had singled themselves out as risk takers, visionaries, bulldogs, pragmatists,…

  19. International Youth Year Features.

    ERIC Educational Resources Information Center

    Palla, Pier Giovanni, Ed.

    1985-01-01

    A digest of ideas and initiatives to make higher education more responsive to young people is provided. Part 1 includes excerpts of articles and reports concerning the International Youth Year (IYY), a United Nations' sponsored year of celebration of youth and a program of meetings to discuss youth problems and solutions. The themes selected for…

  20. Final Year Project Report

    SciTech Connect

    Hubsch, Tristan

    2013-06-20

    In the last years of this eighteen-year grant project, the research efforts have focused mostly on the study of off-shell representations of supersymmetry, both on the worldline and on the world- sheet, i.e., both in supersymmetric quantum mechanics and in supersymmetric field theory in 1+1-dimensional spacetime.

  1. Year 2000 Update.

    ERIC Educational Resources Information Center

    Berg, Frances M.

    1994-01-01

    Presents an update on the Year 2000 objectives for the nation that establish targets in 22 priority areas. The article offers information from a study on exercise by the President's Council on Physical Fitness and Sports, reviews Healthy People 2000 data, and lists Year 2000 physical activity and fitness objectives. (SM)

  2. The year ahead

    SciTech Connect

    Anderson, J.; Marier, D.

    1994-01-01

    Projections by industry leaders of the year ahead show continued strong growth for the independent power industry in Latin America and Asia while the slow pace continues in Europe and North America. A new regulatory pact may emerge in the United States. In the year ahead, industrial leaders in developed countries can be expected to increase pressure for more economic energy rates in order to remain competitive in a global market. This in turn will pressure national utilities to become more competitive also or to privatize. In the United States, a new regulatory pact emerging this year will open access to the grid, increase competition, and bring retail wheeling to the forefront. Most executives interviewed expressed cautious optimism at best about the coming year. While all acknowledge the vast need for power generating capacity throughout most of the world, the financial, legal, and fuel supply infrastructure necessary to successfully build projects will take several years to develop.

  3. Replicability and 40-Year Predictive Power of Childhood ARC Types

    PubMed Central

    Chapman, Benjamin P.; Goldberg, Lewis R.

    2011-01-01

    We examined three questions surrounding the Undercontrolled, Overcontrolled, and Resilient--or Asendorpf-Robins-Caspi (ARC)--personality types originally identified by Block (1971). In analyses of the teacher personality assessments of over 2,000 children in 1st through 6th grade in 1959-1967, and follow-up data on general and cardiovascular health outcomes in over 1,100 adults recontacted 40 years later, we found: (1) Bootstrapped internal replication clustering suggested that Big Five scores were best characterized by a tripartite cluster structure corresponding to the ARC types; (2) this cluster structure was fuzzy, rather than discrete, indicating that ARC constructs are best represented as gradients of similarity to three prototype Big Five profiles; and (3) ARC types and degrees of ARC prototypicality showed associations with multiple health outcomes 40 years later. ARC constructs were more parsimonious, but neither better nor more consistent predictors than the dimensional Big Five traits. Forty-year incident cases of heart disease could be correctly identified with 68% accuracy by personality information alone, a figure approaching the 12-year accuracy of a leading medical cardiovascular risk model. Findings support the theoretical validity of ARC constructs, their treatment as continua of prototypicality rather than discrete categories, and the need for further understanding the robust predictive power of childhood personality traits for mid-life health. PMID:21744975

  4. The Forman Thesis: 40 Years After

    NASA Astrophysics Data System (ADS)

    Carson, Cathryn; Kojevnikov, Alexei; Trischler, Helmuth

    Forty years ago, in 1971, Paul Forman published Weimar Culture, Causality, and Quantum Theory, 1918-1927: Adaptation by German Physicists and Mathematicians to a Hostile Intellectual Environment. His landmark study (too long, too thorough and too fundamental to be called simply an article) became immediately famous, and famously controversial. It has remained at the heart of debates about the historical relationship between science and culture ever since. The controversy surrounding the Forman Thesis was practically unavoidable, for Forman's work put forward and placed at the centre of a broader discussion the argument that the cultural values prevalent in a given place and time could influence the results of discipline-bound research, i.e. the very content of scientific knowledge. This idea, if still controversial, has since become commonly used in cultural studies of science, but at the time of its introduction it created uproar as it explicitly contradicted generally accepted and cherished beliefs about science. Yet tectonic shifts were already underway, if not always visible, that would eventually put those very beliefs into question. The Forman study both reflected and forwarded these shifts in our general perspectives on the nature and practice of science. Despite some heated objections to its findings, Forman's work has fundamentally changed directions of research in the history, sociology and philosophy of science and established itself as a classic in this group of fields, sometimes collectively called science studies. In subsequent decades it has been read and discussed in practically every graduate program that trains students in those fields, circulating in numerous copies and translated into many languages, while the original publication in the journal Historical Studies in the Physical Sciences has long become a bibliographic rarity…

  5. Year-Round School.

    ERIC Educational Resources Information Center

    Gitlin, Lisa

    1988-01-01

    Points made in favor of year-round education include: improved attendance; better coordination of students, vacations, and facilities; fewer discipline problems; less stressful teaching conditions; and continuity benefits for special needs students. (CB)

  6. Year 2000 awareness

    SciTech Connect

    Holmes, C.

    1997-11-01

    This report contains viewgraphs on the challenges business face with the year 2000 software problem. Estimates, roadmaps, virtual factory software, current awareness, and world wide web references are given.

  7. SDO: Year 2

    NASA Video Gallery

    April 21, 2012 marks the two-year anniversary of the Solar Dynamics Observatory (SDO) First Light press conference, where NASA revealed the first images taken by the spacecraft. This video highligh...

  8. Edward D. Goldberg's proposal of "the Mussel Watch": Reflections after 40years.

    PubMed

    Farrington, John W; Tripp, Bruce W; Tanabe, Shinsuke; Subramanian, Annamalai; Sericano, José L; Wade, Terry L; Knap, Anthony H

    2016-09-15

    We chronicle the extensive influence over the past forty years of Professor Edward D. Goldberg and his call in 1975 for a "Mussel Watch" or bivalve sentinel organism approach to assess geographic status and temporal trends of several chemicals of environmental concern in the coastal ocean. Examples of local, regional, national and international programs are discussed briefly as are examples of interesting useful findings and limitations to the Mussel Watch concept. Mussel Watch continues to provide useful data about status and trends of chemical contamination in coastal ecosystems.

  9. Magic memories: young children's verbal recall after a 6-year delay.

    PubMed

    Jack, Fiona; Simcock, Gabrielle; Hayne, Harlene

    2012-01-01

    This report describes the first prospective study specifically designed to assess children's verbal memory for a unique event 6 years after it occurred. Forty-six 27- to 51-month-old children took part in a unique event and were interviewed about it twice, after 24-hr and 6-year delays. During the 6-year interview, 9 children verbally recalled the event, including 2 who were under 3 years old when the event occurred. This may be the most convincing evidence to date that such early experiences can be verbally recalled after long delays. These data have important implications for current theories of memory development and childhood amnesia and underscore some of the problems associated with evaluating the veracity of early memories under less controlled conditions.

  10. Emergent technologies: 25 years

    NASA Astrophysics Data System (ADS)

    Rising, Hawley K.

    2013-03-01

    This paper will talk about the technologies that have been emerging over the 25 years since the Human Vision and Electronic Imaging conference began that the conference has been a part of, and that have been a part of the conference, and will look at those technologies that are emerging today, such as social networks, haptic technologies, and still emerging imaging technologies, and what we might look at for the future.Twenty-five years is a long time, and it is not without difficulty that we remember what was emerging in the late 1980s. Yet to be developed: The first commercial digital still camera was not yet on the market, although there were hand held electronic cameras. Personal computers were not displaying standardized images, and image quality was not something that could be talked about in a standardized fashion, if only because image compression algorithms were not standardized yet for several years hence. Even further away were any standards for movie compression standards, there was no personal computer even on the horizon which could display them. What became an emergent technology and filled many sessions later, image comparison and search, was not possible, nor the current emerging technology of social networks- the world wide web was still several years away. Printer technology was still devising dithers and image size manipulations which would consume many years, as would scanning technology, and image quality for both was a major issue for dithers and Fourier noise.From these humble beginnings to the current moves that are changing computing and the meaning of both electronic devices and human interaction with them, we will see a course through the changing technology that holds some features constant for many years, while others come and go.

  11. New year, old hat

    NASA Astrophysics Data System (ADS)

    American Geological Institute; American Institute of Physics; American Associationthe Advancement of Science; Carlowicz, Michael

    It is only August, but October 1 looms large on the calendar. That is the day when the 1997 fiscal year (FY ‧97) begins for the U.S. federal government, and like last year, that day might come without a budget.In a flurry of summer activity, the U.S. Congress has passed several landmark bills on welfare reform, expansion of health coverage for workers between jobs, a raise in the minimum wage, and a Safe Drinking Water Act. The House of Representatives even passed all 13 of its annual appropriations bills before Congress took its August recess.

  12. Ten years of reviews.

    PubMed

    Grant, Maria J

    2017-03-01

    The March 2017 issue of the Health Information and Libraries Journal marks the 10 year anniversary of the inaugural review published in the journal's review series. The review series was conceived to meet the growing appetite of health library and information workers to access synthesised evidence to inform their practice; something we'd already been doing to support medics in their practice. This editorial looks back on the 10 years and the inspiration which saw the development of a typology of review types and associated methodologies to address the lack of consistent guidelines on the features a review should incorporate.

  13. Replicability and 40-year predictive power of childhood ARC types.

    PubMed

    Chapman, Benjamin P; Goldberg, Lewis R

    2011-09-01

    We examined 3 questions surrounding the undercontrolled, overcontrolled, and resilient-or Asendorpf-Robins-Caspi (ARC)-personality types originally identified by Block (1971). In analyses of the teacher personality assessments of over 2,000 children in 1st through 6th grade in 1959-1967 and follow-up data on general and cardiovascular health outcomes in over 1,100 adults recontacted 40 years later, we found bootstrapped internal replication clustering suggesting that Big Five scores were best characterized by a tripartite cluster structure corresponding to the ARC types. This cluster structure was fuzzy rather than discrete, indicating that ARC constructs are best represented as gradients of similarity to 3 prototype Big Five profiles; ARC types and degrees of ARC prototypicality showed associations with multiple health outcomes 40 years later. ARC constructs were more parsimonious but, depending on the outcome, comparable or slightly worse classifiers than the dimensional Big Five traits. Forty-year incident cases of heart disease could be correctly identified with 67% accuracy by childhood personality information alone and stroke incidence with over 70% accuracy. Findings support the theoretical validity of ARC constructs, their treatment as continua of prototypicality rather than discrete categories, and the need for further understanding the robust predictive power of childhood personality for midlife health.

  14. 5-Year Budget Forecasting.

    ERIC Educational Resources Information Center

    Conyers, John G.; Lingel, George; Piekarski, Robert

    2000-01-01

    Financial planning is the key to providing a high-quality instructional plan. A 5-year financial plan is typically updated by looking at district financial history, future instructional plans, staffing requirements, and revenue projections. Planning assumptions must be clearly understood by the financial team and the community. (MLH)

  15. One Week Every Year.

    ERIC Educational Resources Information Center

    LeBuffe, James R.

    1991-01-01

    Guidelines are offered to schools and communities for developing activities of a yearly Deaf Awareness Week. Topics covered should include general information about deafness; common myths and misunderstandings; information about sign languages; technologies available to deaf people; interpreting; and interaction among deaf and hearing students.…

  16. Fifty years in neonatology.

    PubMed

    Manley, Brett J; Doyle, Lex W; Davies, Mark W; Davis, Peter G

    2015-01-01

    Neonatology, the care and study of newborn infants, is a 'young' specialty. Over the last 50 years, there have been many advances in the way that neonatologists care for newborn infants, particularly those born preterm, leading to dramatic improvements in mortality. To illustrate these advances, we describe four eras in neonatology from the point of view of the junior hospital doctor.

  17. The Turbulent Years.

    ERIC Educational Resources Information Center

    Scanlon, John, Ed.

    This summary of the Fourth Annual Conference on Major Transitions in the Human Life Cycle contains a preface, introductory section on adolescence and young adulthood (ages 14 through 24 years), and the following presentations, complete with discussion text: (1) "Historical Treatment of the Age Group" (John Demos); (2) "Demographic Considerations"…

  18. Black Studies Year One.

    ERIC Educational Resources Information Center

    Long, Richard A.

    Though Dubois tried to begin a series of scientific studies on the Negro problem in America more than 70 years ago, only recently have attempts been made to present a true history of the Black man in institutions of higher learning. Until that time, the experience of the Black man was defined in Euro-American terms, or in most cases was completely…

  19. Reflections, 15 Years Later

    ERIC Educational Resources Information Center

    Knox, George

    2016-01-01

    George Knox reflects on his 15-year career as president of Labette Community College in Parsons, Kansas. Knox writes that, as a first-time president coming into a brand new system, he was very fortunate to have many seasoned presidents and mentors in Kansas and from the American Association of Community Colleges' (AACC) Presidents Academy. He says…

  20. Creativity: The Early Years

    ERIC Educational Resources Information Center

    Shade, Rick; Shade, Patti Garrett

    2016-01-01

    There is a myth that some people are creative and others are not. However, all children are born creative. They love to explore, ask questions, and are incredibly imaginative. Parents are key in nurturing their child's creativity in the early years. This article offers resources and strategies parents can use at different ages and stages (newborn,…

  1. Smog - the learning years

    SciTech Connect

    Heinen, C.M.; Fagley, W.S. Jr.

    1989-01-01

    35 years of continuous work by government and industry and the public have led to a very sophisticated system of emission controls. This paper is intended to recall and perhaps to honor those who participated in the hectic early period, when instrumentation, basic knowledge, and primitive devices competed for the attention of these pioneers with strident demands from policitians.

  2. Year of the Coast.

    ERIC Educational Resources Information Center

    Jacobik, Gray; Lux, Gretchen

    1980-01-01

    President Carter has designated 1980 as the "Year of the Coast" through the efforts of a coalition known as the Coast Alliance. The Coast Alliance will alert people to changes along the coastline, and the need for public participation in the decisions which govern the use and abuse of the coastline. (DS)

  3. Year-Round Schools.

    ERIC Educational Resources Information Center

    McChesney, Jim

    1996-01-01

    One avenue being explored as a way to cut costs while maintaining the quality of programs and services is year-round education (YRE). In most cases, the known benefits and drawbacks of an existing component of traditional scheduling must be weighed against the theoretical advantages and disadvantages of YRE. The five articles reviewed in this…

  4. Working with Year 6

    ERIC Educational Resources Information Center

    Hall, Peter

    2006-01-01

    This paper discusses the three outreach projects in Kent, a girls grammar school with a mixed sixth form. Due to the selective system in Kent they have around 100 potential feeder schools with their Year 7 intake of around 150 arriving from about 70 different primary schools, some of which are independent. In this article, the author describes the…

  5. Five Years Later

    ERIC Educational Resources Information Center

    Hill, Jeremiah

    2004-01-01

    In this article, the author relates some of the bitter realizations he encountered during his student-teaching years when he realized that not all teachers were willing to help novice teachers. Some of them seemed to believe that teaching is as instinctive to a teacher as flight is to a bird. Despite these obstacles, the author states that he…

  6. The Lost Years

    ERIC Educational Resources Information Center

    Zehr, Mary Ann; Mousa, Yasmine

    2008-01-01

    Thousands of children were deprived of schooling in the difficult aftermath of the U.S.-led invasion of Iraq five years ago. During those times, more than 2 million Iraqis have fled their homeland, mainly to Jordan and Syria. Even though the schoolchildren who came to these neighboring Arab lands with their families are now given seats in…

  7. European Music Year 1985.

    ERIC Educational Resources Information Center

    Alexanderson, Thomas; And Others

    1984-01-01

    Articles concerning music are included in this newsletter dedicated to cultural venture to be jointly carried out by the Council of Europe and the European communities. Many events will mark Music Year 1985, including concerts, dance performances, operas, publications, recordings, festivals, exhibitions, competitions, and conferences on musical…

  8. Mathematics 9th Year.

    ERIC Educational Resources Information Center

    New York City Board of Education, Brooklyn, NY. Bureau of Curriculum Development.

    The Materials in this bulletin indicate suggested teaching procedures needed to implement the teaching of "mathematics, 9th Year" as outlined in Curriculum Bulletin No. 3, 1958-59 series, Course of Study Mathematics 7-8-9. Whereas the course of study suggests the application of mathematical principles such as commutativity,…

  9. Chinese New Year Dragons.

    ERIC Educational Resources Information Center

    Balgemann, Linda

    2000-01-01

    Presents an art project, used in a culturally diverse curriculum, in which second grade students create Chinese New Year dragons. Describes the process of creating the dragons, from the two-week construction of the head to the accordion-folded bodies. (CMK)

  10. Affordances: Ten Years On

    ERIC Educational Resources Information Center

    Brown, Jill P.; Stillman, Gloria

    2014-01-01

    Ten years ago the construct, affordance, was rising in prominence in scholarly literature. A proliferation of different uses and meanings was evident. Beginning with its origin in the work of Gibson, we traced its development and use in various scholarly fields. This paper revisits our original question with respect to its utility in mathematics…

  11. EDITORIAL: 80 Years of Plasma 80 Years of Plasma

    NASA Astrophysics Data System (ADS)

    Franklin, R. N.; Braithwaite, N. St J.

    2009-02-01

    Irving Langmuir proposed the term 'plasma' in a paper in 1928 (Proc. Natl Acad. Sci. USA 14 627-637) to describe a 'region containing balanced charges of ions and electrons'. There does not appear to be any record of the thinking behind this proposal, so it is difficult to be definitive. One idea is that since the Greek word 'plasma' was used to describe a mouldable fluid, 'neon' lighting, with its almost limitless ability to provide colourful shapes, provided the inspiration. Another relates to the prior medical use in relation to blood with its variety of different 'corpuscles' and that the essential description of the positive column required one to recognize at least the role of the separate species of electrons, ions and gas atoms. Tonks, when questioned thirty years later, was inclined to the latter idea, but it is unlikely that we shall ever know for certain. (See postscript added December 2008.) Forty years ago most of the interest in terrestrial plasmas was centred on fusion and the prospect of thus solving the world's energy problems; the quest continues. However, since then a whole new industry has developed. It emerged in the 1970s as an imaginative way to remove the photoresist layers used in patterning semiconductor wafers. Slowly but steadily, plasma-based 'dry' processes began to displace the traditional wet chemistry processes of cleaning, etching and depositing by which the first generation of integrated circuits had been made. Plasma technology offered higher yields while accommodating the complexity of ever-shrinking feature size, driving the microelectronic revolution for almost four decades. Langmuir certainly ushered in an exciting branch of physics when he introduced the term plasma. We have included as Appendix I a condensed CV for Irving Langmuir to show, amongst other things, the early influences on his subsequent life. An interlude in Paris gave him a taste of the wider world of Europe. His subsequent schooling in the United States led

  12. Developmental milestones record - 2 years

    MedlinePlus

    Growth milestones for children - 2 years; Normal childhood growth milestones - 2 years; Childhood growth milestones - 2 years ... a cause for concern if not seen by 2 years.) Can run with better coordination . (May still ...

  13. Developmental milestones record - 3 years

    MedlinePlus

    ... years; Growth milestones for children - 3 years; Childhood growth milestones - 3 years; Well child - 3 years ... activities related to your child's interests. Encourage your child to use words to express feelings (rather than acting out).

  14. Developmental milestones record - 5 years

    MedlinePlus

    ... Childhood growth milestones - 5 years; Growth milestones for children - 5 years; Well child - 5 years ... skill milestones for a typical 5-year-old child include: Gains about 4 to 5 pounds (1. ...

  15. Safety and Efficacy of Fingolimod and Natalizumab in Multiple Sclerosis After the Failure of First-Line Therapy: Single Center Experience Based on the Treatment of Forty-Four Patients

    PubMed Central

    Puz, Przemysław; Lasek-Bal, Anetta

    2016-01-01

    Background In Poland, natalizumab or fingolimod treatment can be delivered as a second-line therapy to those patients with relapsing-remitting multiple sclerosis (RRMS) who demonstrated no response to interferon or glatiramer acetate treatment for a minimum of one year. The objective of this study was to evaluate the impact of second-line therapy on the frequency of relapses, the disability progression, and the occurrence of side effects. Material/Methods Analysis covered 44 RRMS patients switched from first- to second-line therapy. The annualized relapse rate, disability progression (assessed with Expanded Disability Status Scale, EDSS) and MRI results (new or enlarged T2 lesions and new Gd-positive lesions) before and after switching were compared. The occurrence of adverse events was also assessed. Results The annualized relapse rate for second-line therapy was significantly lower than for first-line therapy (0.35±0.74 vs. 2.13±0.87, p=0.00005). Median of EDSS progression with first-line therapy was significantly higher than that with natalizumab or fingolimod treatment (p=0.00002). The mean number of new or enlarged T2 and Gd+ lesions in MRI after one-year second-line treatment was significantly lower in comparison to lesions in MRI performed at the end of the first-line therapy (for T2: 0.61 vs. 4.56, p=0.0004; for Gd+: 0.13 vs. 1.98, p=0.0009). No significant differences in the clinical data, MRI results, and side effects between fingolimod and natalizumab patients have been observed. Conclusions Treatment with natalizumab or fingolimod as a second-line therapy in RRMS patients is safe and effective. Less restrictive criteria for switching should be considered. PMID:27829656

  16. Ten Years of Chandra

    NASA Technical Reports Server (NTRS)

    Weisskopf, Martin C.

    2009-01-01

    We celebrated the 10-th anniversary of the Launch of the Chandra X-ray Observatory on July 13, 2009. During these 10 years data from this Great Observatory have had a profound impact on 21st century astrophysics. With its unrivaled capability to produce sub-arcsecond images, the Observatory has enabled astronomers to make new discoveries in topics as diverse as comets and cosmology. We shall review some of the highlights, discuss the current status, and future plans.

  17. Forty Years after Brown: The Impact of Race and Ethnicity on the Recruitment and Retention of Minorities in Education. Proceedings of the National Conference on Recruitment and Retention of Minorities in Education (9th, Oswego, NY, April 9-11, 1995).

    ERIC Educational Resources Information Center

    Middleton, E., Ed.; And Others

    The proceedings identify, clarify, and address the problems of the post-Brown era from a variety of perspectives. The first two papers are: The Dr. Martin Luther King, Jr. Banquet Keynote Speech (L. J. Bennett) and the Luncheon Session, "Integrating the Recruitment Preparation and Retention Strategies of Persons of Color in Teaching" (J.…

  18. Five Year Flashlight

    NASA Technical Reports Server (NTRS)

    1978-01-01

    An ultra-reliable flashlight, initially developed for rescue signaling and utility use by NASA astronauts and military aircrews, has attracted a broad commercial market. Called the Five Year Light, it has a shelf life at least that long because there is no power drain on the batteries when the flashlight is not in use. The NASA version of the light was developed under contract with Langley Research Center by ACR Electronics, Inc., now known as the Chromalloy Electronics Division of Chromalloy American Corporation, Hollywood, Florida. NASA wanted a light that had long shelf life and assured reliability in case it was needed in an emergency. Reliability was designed into the flashlight by means of a unique switch. Instead of the customary thumb-button, the Five Year Light is turned on by rotating its collar to make contact with the battery terminal; the turning motion wipes away any corrosion that might be present and makes contact virtually certain. The Five Year Light available commercially is a repackaged version of the NASA light. It is sold for car, home, industrial, police, firefighting, recreational and a variety of other uses, and sales have topped two million units.

  19. 40 Years of Discovery

    SciTech Connect

    Weinstein, B; Heller, A

    2003-07-08

    History is most interesting when seen through the eyes of those who lived it. In this 40th anniversary retrospective of bioscience research at Lawrence Livermore National Laboratory, we've asked 19 scientists to share their personal recollections about a major accomplishment in the program's history. We have not tried to create a comprehensive or seamless story. Rather, we've attempted to capture the perspectives of key individuals, each of whom worked on a research program that met significant milestones. We have focused particularly on programs and accomplishments that have shaped the current Biology and Biotechnology Research Program (BBRP). In addition, we have included a timeline of biosciences at LLNL, a history of the directorate that appeared in the Laboratory's magazine, ''Science & Technology Review'', in 2002, and a list of bioscience-related articles that have appeared over the years in ''Science & Technology Review and its predecessor, Energy & Technology Review''. The landscape of biological science today is stunningly different from 40 years ago. When LLNL bioscience began in 1963, we knew about the structure of DNA and that it was the carrier of genetic information. However, it would be another year before scientists would understand how DNA codes for the production of proteins and more than a decade before the earliest DNA sequence would be known. It is sometimes difficult to remember that it was only 15 years ago that the polymerase chain reaction, a synthetic method to amplify pieces of DNA was developed, and that only within the last half-dozen years has sequence data for entire organisms begun to be available. In this publication, we have tried to capture some of the landmark and seminal research history: radiation effects studies, which were a major reason for founding the biological research program, and flow sorting and chromosome painting, which dramatically changed our ability to study DNA damage and enabled the creation of chromosome

  20. Comparison of the effects block and traditional schedules have on the number of students who are proficient on the Biology End-of-Course Test in forty public high schools in the state of North Carolina

    NASA Astrophysics Data System (ADS)

    Bonner, Tonia Anita

    This study examined the difference between the number of overall students, African-American students, and students with disabilities on a semester 4 x 4 block schedule who were proficient on the North Carolina Biology End-of-Course Test and the number of the same group of students on a traditional 45-50 minute yearlong schedule who were proficient on the NC Biology End-of-Course Test in the state of North Carolina during the 2009--2010 school year. A causal-comparative design was used and three null hypotheses were tested using chi-square analysis. Archival data was used. The results showed that there was a significant association between the number of the overall students and African-American students who were proficient on the NC Biology EOC Test when taught biology on a 4 x 4 semester block versus a traditional schedule. However, no statistically significant relationship existed between the number of students with disabilities who were educated on 4 x 4 semester block schedule and those students with disabilities who were educated on a six or seven period traditional schedule in biology. Suggestions for further research are included.

  1. Therapeutic Efficacy of Neurostimulation for Depression: Techniques, Current Modalities, and Future Challenges.

    PubMed

    Akhtar, Hafsah; Bukhari, Faiza; Nazir, Misbah; Anwar, Muhammad Nabeel; Shahzad, Adeeb

    2016-02-01

    Depression is the most prevalent debilitating mental illness; it is characterized as a disorder of mood, cognitive function, and neurovegetative function. About one in ten individuals experience depression at some stage of their lives. Antidepressant drugs are used to reduce the symptoms but relapse occurs in ~20% of patients. However, alternate therapies like brain stimulation techniques have shown promising results in this regard. This review covers the brain stimulation techniques electroconvulsive therapy, transcranial direct current stimulation, repetitive transcranial magnetic stimulation, vagus nerve stimulation, and deep brain stimulation, which are used as alternatives to antidepressant drugs, and elucidates their research and clinical outcomes.

  2. Reliability of a novel neurostimulation method to study involuntary muscle phenomena.

    PubMed

    Minetto, Marco Alessandro; Botter, Alberto; Ravenni, Roberta; Merletti, Roberto; De Grandis, Domenico

    2008-01-01

    Experimental methods involving painful electrical stimulation of a peripheral nerve showed the existence of a minimum stimulation frequency capable of inducing cramp, termed "threshold frequency" (TF). Our aim was to test an alternative method to induce fasciculations and cramps electrically. Two daily sessions of electrical stimulation of the abductor hallucis muscle were performed in 19 volunteers on 3 days: stimulation trains of 150 monophasic square pulses (duration 152 micros) of increasing frequency (current intensity 30% higher than maximal; frequency of the first trial, 4 pps; recovery between trials, 1 min) were delivered to the main muscle motor point until a cramp developed. Once a cramp was induced the protocol was repeated after 30 min. To verify by electromyography that cramp occurred, a surface electrode array was placed between the motor point and the distal tendon. Ambient and skin temperature were kept constant in all sessions. Fasciculations and cramps were elicited in all subjects. We observed the following median (interquartile range) values of TF: day 1 (session 1), 13 (6) pps; day 1 (session 2), 16 (4) pps; day 2 (session 1), 16 (6) pps; day 2 (session 2), 18 (6) pps; day 3 (session 1), 17 (4) pps; day 3 (session 2), 18 (8) pps. TF intersession intraclass correlation coefficients were 0.82, 0.92, and 0.90 for days 1, 2, and 3, respectively. TF interday intraclass correlation coefficient was 0.85. The absence of pain due to the stimulation and the demonstration of TF reliability support the use of our method for the study of involuntary muscle phenomena.

  3. A CMOS Current Steering Neurostimulation Array With Integrated DAC Calibration and Charge Balancing.

    PubMed

    Greenwald, Elliot; Maier, Christoph; Wang, Qihong; Beaulieu, Robert; Etienne-Cummings, Ralph; Cauwenberghs, Gert; Thakor, Nitish

    2017-04-01

    An 8-channel current steerable, multi-phasic neural stimulator with on-chip current DAC calibration and residue nulling for precise charge balancing is presented. Each channel consists of two sub-binary radix DACs followed by wide-swing, high output impedance current buffers providing time-multiplexed source and sink outputs for anodic and cathodic stimulation. A single integrator is shared among channels and serves to calibrate DAC coefficients and to closely match the anodic and cathodic stimulation phases. Following calibration, the differential non-linearity is within ±0.3 LSB at 8-bit resolution, and the two stimulation phases are matched within 0.3%. Individual control in digital programming of stimulation coefficients across the array allows altering the spatial profile of current stimulation for selection of stimulation targets by current steering. Combined with the self-calibration and current matching functions, the current steering capabilities integrated on-chip support use in fully implanted neural interfaces with autonomous operation for and adaptive stimulation under variations in electrode and tissue conditions. As a proof-of-concept we applied current steering stimulation through a multi-channel cuff electrode on the sciatic nerve of a rat.

  4. Light pattern preservation in rodent's cortical tissue during optogenetic neuro-stimulation (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Azimipour, Mehdi; Atry, Farid; Pashaie, Ramin

    2016-03-01

    Optogenetics provides a tool for modulating activity of specific cell types by light pulses. Different light delivery mechanisms such as single optical fiber implanted on a skull or patterned illumination can be employed to direct light to a target area. For a highly scattering medium such as brain tissue, light distribution significantly depends on the scattering parameters of the tissue as well as the inherent inhomogeneity of the specimen. For in vivo studies, blood vessels which have considerable absorption coefficient in the visible spectrum play a major role in producing such inhomogeneity. Therefore, detailed information about brain optical properties and network of blood vessels which was ignored in previous studies is necessary to accurately predict light distribution and designing light delivery mechanism during optogenetic experiments to achieve the desired optical stimulation. In this paper, light pattern preservation while considering the impact of blood vessels is investigated in a rat cortex. First, the typical optical properties of rat cortical tissue were extracted by employing double integrated sphere technique, and then, optical coherence tomography was employed to obtain structure of blood vessels on the cortex. By combining the extracted optical properties and the network of blood vessels, a three-dimensional model of a rat cortical tissue was developed. Then, a Monte Carlo simulation code was used to predict light distribution in this model for different light source configurations and wavelengths. The results confirm that presence of vessels can significantly impact the light pattern in the tissue and affect the practical depth of penetration.

  5. Redundant safety features in a high-channel-count retinal neurostimulator

    PubMed Central

    Kelly, Shawn K.; Ellersick, William F.; Krishnan, Ashwati; Doyle, Patrick; Shire, Douglas B.; Wyatt, John L.; Rizzo, Joseph F.

    2016-01-01

    Safety features embedded in a 256-channel retinal prosthesis integrated circuit are presented. The biology of the retina and the electrochemistry of the electrode-tissue interface demand careful planning and design of the safety features of an implantable retinal stimulation device. We describe the internal limits and communication safety features of our ASIC, but we focus on monitoring and protection circuits for the electrode-tissue interface. Two independent voltage monitoring circuits for each channel measure the electrode polarization voltage at two different times in the biphasic stimulation cycle. The monitors ensure that the charged electrode stays within the electrochemical water window potentials, and that the discharged electrode is within a small window near the counter electrode potential. A switch to connect each electrode to the counter electrode between pulses protects against a wide range of device failures. Additionally, we describe work on an active feedback system to ensure that the electrode voltage is at zero. PMID:27231724

  6. A practical application of text mining to literature on cognitive rehabilitation and enhancement through neurostimulation

    PubMed Central

    Balan, Puiu F.; Gerits, Annelies; Vanduffel, Wim

    2014-01-01

    The exponential growth in publications represents a major challenge for researchers. Many scientific domains, including neuroscience, are not yet fully engaged in exploiting large bodies of publications. In this paper, we promote the idea to partially automate the processing of scientific documents, specifically using text mining (TM), to efficiently review big corpora of publications. The “cognitive advantage” given by TM is mainly related to the automatic extraction of relevant trends from corpora of literature, otherwise impossible to analyze in short periods of time. Specifically, the benefits of TM are increased speed, quality and reproducibility of text processing, boosted by rapid updates of the results. First, we selected a set of TM-tools that allow user-friendly approaches of the scientific literature, and which could serve as a guide for researchers willing to incorporate TM in their work. Second, we used these TM-tools to obtain basic insights into the relevant literature on cognitive rehabilitation (CR) and cognitive enhancement (CE) using transcranial magnetic stimulation (TMS). TM readily extracted the diversity of TMS applications in CR and CE from vast corpora of publications, automatically retrieving trends already described in published reviews. TMS emerged as one of the important non-invasive tools that can both improve cognitive and motor functions in numerous neurological diseases and induce modulations/enhancements of many fundamental brain functions. TM also revealed trends in big corpora of publications by extracting occurrence frequency and relationships of particular subtopics. Moreover, we showed that CR and CE share research topics, both aiming to increase the brain's capacity to process information, thus supporting their integration in a larger perspective. Methodologically, despite limitations of a simple user-friendly approach, TM served well the reviewing process. PMID:25309356

  7. 500 years after Columbus.

    PubMed

    Imbach, A

    1992-01-01

    The astonishing range of plants and animals of Central America's 7 countries (Guatemala, Belize, Honduras, El Salvador, Nicaragua, Costa Rica and Panama) is disappearing, as 60% of its forests have been cut for lumber and firewood as well as for cotton, cattle, or subsistence crops. Up to 5 million Mayans lived sustainably for thousands of years in an area now being destroyed by a few hundred thousand inhabitants. The Spanish colonization that started 500 years ago was concentrated in Panama, Nicaragua, and Guatemala. The majority of the English-speaking country of Belize are descended from the black slave population whose culture spread down the coast to Central America. Panama's service economy is based on the Panama Canal and trade and finance. Costa Rica benefits from a tourist industry based on its natural beauty, however, it also has the highest rate of deforestation and its fast population growth could jeopardize earlier social and economic progress. In El Salvador and Guatemala long periods of civil conflict have taken their toll on the economy and the environment. El Salvador has a mountainous territory and limited natural resources and industrialization, while the best land is in the hands of a few families. Honduras and Nicaragua retain the highest proportion of forest cover of the countries in the region, despite Nicaragua's years of tyranny, then revolution and the Contra war, and Honduras's own turmoils. Belize has achieved some stability, and is now strengthening its Central American links. Its coral reefs and coastal areas offer potential for sustainable development through fishing and tourism. Central American countries face the challenges of their fragile environments and major social problems.

  8. Natural history of herpes zoster: late follow-up of 3.9 years (n=43) and 7.7 years (n=10).

    PubMed

    Reda, Haatem; Greene, Kaitlin; Rice, Frank L; Rowbotham, Michael C; Petersen, Karin L

    2013-10-01

    Postherpetic neuralgia (PHN) is a common complication after herpes zoster (HZ). Subjects who completed a longitudinal observational 6-month study (4 visits) of the natural history of HZ were recontacted for 2 additional follow-up visits that included pain and sensory symptom assessment, quantitative sensory testing, capsaicin response test, and 3-mm punch skin biopsies in HZ-affected, mirror-image, and control skin sites. Forty-three subjects (14 with PHN at 6 months) of the original 94 subjects in the cohort were comprehensively assessed at a median 3.9 years after HZ onset (visit 5), and 10 subjects underwent a final assessment at a median 7.7 years after HZ onset (visit 6). At 3.9 years, none of the 29 subjects who had been pain free at 6 months had a recurrence of pain. Only 2 of the 14 subjects with PHN at 6 months still had pain at 3.9 years. One subject with PHN at 6 months was free of symptoms at 3.9 years but had very mild pain at 7.7 years. Sensory function continued on a path toward normalization, but was still abnormal in many subjects, especially those who met criteria for PHN at 6 months. Even at 7.7 years, reinnervation of HZ-affected skin was not apparent.

  9. NAS: The first year

    NASA Technical Reports Server (NTRS)

    Bailey, F. R.; Kutler, Paul

    1988-01-01

    Discussed are the capabilities of NASA's Numerical Aerodynamic Simulation (NAS) Program and its application as an advanced supercomputing system for computational fluid dynamics (CFD) research. First, the paper describes the NAS computational system, called the NAS Processing System Network, and the advanced computational capabilities it offers as a consequence of carrying out the NAS pathfinder objective. Second, it presents examples of pioneering CFD research accomplished during NAS's first operational year. Examples are included which illustrate CFD applications for predicting fluid phenomena, complementing and supplementing experimentation, and aiding in design. Finally, pacing elements and future directions for CFD and NAS are discussed.

  10. Solar 22 years cycle

    NASA Astrophysics Data System (ADS)

    Kotov, Valery A.; Sanchez, Francis M.

    2017-01-01

    Seven observatories performed in 1968-2015 numerous daily measurements of general magnetic field of the Sun seen as a star (of a mean line-of-sight field component of the visible solar hemisphere). The new data 2013-2015 confirmed the recent prediction about saw-edged profile of the mean curve of the Hale's 22 years magnetic cycle and, thus, a hypothesis about its cosmological (partial) origin. This is supported by a special analysis of epochs of extrema of Wolf's sunspot number, demonstrating a remarkable stability, since Galileo's time, of the initial phase of the cycle, which can hardly be explained by dynamo theory exclusively.

  11. Multiple-address radio systems, allocation of forty-eight 25 kHz channels in the 900 MHz range; and establishment of a new standard for frequency tolerance in the 952-960 MHz band: Federal Communications Commission. Third notice of proposed rulemaking.

    PubMed

    1981-02-04

    In response to a petition, the Commission proposes the reallocation of forty-eight 25 kHz channels in the 928-929 and 952-960 MHz band segments to the Private Operational-Fixed Microwave Service and the Domestic Public Land Mobile Radio Service for distribution automation and wide-area control and repeater operations, respectively. The spectrum from 928 to 929 MHz is presently reserved for Land Mobile. The 952-950 MHz band is currently allocated to the Private Operational-Fixed Microwave Service and the International Control Services.

  12. Hanford Cultural Resources Laboratory annual report for Fiscal Year 1991

    SciTech Connect

    Chatters, J.C.; Gard, H.A.

    1992-08-01

    The Hanford Cultural Resources Laboratory (HCRL) was established by the US Department of Energy, Richland Field Office (RL) in 1987 as part of Pacific Northwest Laboratory. The HCRL provides support for managing the archaeological, historical, and cultural resources of the Hanford Site, Washington, in a manner consistent with the National Historic Preservation Act of 1966 (NHPA), the Archaeological Resources Protection Act of 1979 and the American Indian Religious Freedom Act of 1978. HCRL responsibilities have been set forth in the Hanford Cultural Resources Management Plan (HCRMP) as a prioritized list of tasks to be undertaken to keep the RL in compliance with federal statutes, regulations and guidelines. For fiscal year 1991 these tasks were to (1) ensure compliance with NHPA Section 106, (2) monitor the condition of known archaeological sites, (3) evaluate cultural resources for potential nomination to the National Register of Historic Places, (4) educate the public about cultural resources, (5) conduct a sample archaeological survey of Hanford lands, and (6) gather ethnohistorical data from Indian elders. Research conducted as a spinoff from these tasks is also reported. The archaeological site monitoring program is designed to determine whether the RL`s cultural resource management and protection policies are effective; results are used in planning for cultural resource site management and protection. Forty-one sites were monitored during this fiscal year.

  13. Hanford Cultural Resources Laboratory annual report for Fiscal Year 1991

    SciTech Connect

    Chatters, J.C.; Gard, H.A.

    1992-08-01

    The Hanford Cultural Resources Laboratory (HCRL) was established by the US Department of Energy, Richland Field Office (RL) in 1987 as part of Pacific Northwest Laboratory. The HCRL provides support for managing the archaeological, historical, and cultural resources of the Hanford Site, Washington, in a manner consistent with the National Historic Preservation Act of 1966 (NHPA), the Archaeological Resources Protection Act of 1979 and the American Indian Religious Freedom Act of 1978. HCRL responsibilities have been set forth in the Hanford Cultural Resources Management Plan (HCRMP) as a prioritized list of tasks to be undertaken to keep the RL in compliance with federal statutes, regulations and guidelines. For fiscal year 1991 these tasks were to (1) ensure compliance with NHPA Section 106, (2) monitor the condition of known archaeological sites, (3) evaluate cultural resources for potential nomination to the National Register of Historic Places, (4) educate the public about cultural resources, (5) conduct a sample archaeological survey of Hanford lands, and (6) gather ethnohistorical data from Indian elders. Research conducted as a spinoff from these tasks is also reported. The archaeological site monitoring program is designed to determine whether the RL's cultural resource management and protection policies are effective; results are used in planning for cultural resource site management and protection. Forty-one sites were monitored during this fiscal year.

  14. Einstein's Years in Switzerland

    NASA Astrophysics Data System (ADS)

    Plendl, Hans S.

    2005-11-01

    Albert Einstein left Germany, the country of his birth, in 1894 and moved to Switzerland in 1895. He studied, worked and taught there, except for a year's stay in Prague, until1914. That year he returned to Germany, where he lived until his emigration to the United States in 1933. In 1905, while living with his wife Mileva and their first son Hans Albert in Bern and working as a technical expert at the Swiss Patent Office, he published his dissertation on the determination of molecular dimensions, his papers on Brownian Motion that helped to establish the Kinetic Theory of Heat and on the Photo-Electric Effect that validated the Quantum Theory of Light, and the two papers introducing the Special Theory of Relativity. How the young Einstein could help to lay the foundations of these theories while still working on his dissertation, holding a full-time job and helping to raise a family has evoked much discussion among his biographers. In this contribution, the extent to which living within Swiss society and culture could have made this feat possible will be examined. Old and recent photos of places in Switzerland where Einstein has lived and worked will be shown.

  15. The 34 Year Starship

    NASA Astrophysics Data System (ADS)

    Nosanov, J.; Shapiro, A.; Garrett, H.

    2012-09-01

    In 1974, the designers and leadership of a mission then known as ``Mariner Jupiter Saturn 1977'' decided that the name was a mouthful. They briefly deliberated and decided to rename it ``Voyager'' [1]. Similarly, we believe that ``DARPA 100 Year Starship'' is unnecessarily verbose. We propose to call it ``Enterprise.'' Among the many challenges facing such a mission is that of earning public support - we should let half a century of Hollywood storytelling do that for us. This paper is composed of four parts. Part 1 will discuss the parallels between the Voyager program and a future Enterprise program. Part 2 will go into greater detail regarding the Voyager program and the challenges and opportunities that defined it. Part 3 will discuss some of the major technical challenges for Voyager and Enterprise in greater detail. Part 4 will discuss next steps and various strategies to meet DARPA's challenge of sustainable industry-funded research into interstellar flight.

  16. Nebulized therapy. SEPAR year.

    PubMed

    Olveira, Casilda; Muñoz, Ana; Domenech, Adolfo

    2014-12-01

    Inhaled drugs are deposited directly in the respiratory tract. They therefore achieve higher concentrations with faster onset of action and fewer side effects than when used systemically. Nebulized drugs are mainly recommended for patients that require high doses of bronchodilators, when they need to inhale drugs that only exist in this form (antibiotics or dornase alfa) or when they are unable to use other inhalation devices. Technological development in recent years has led to new devices that optimize pulmonary deposits and reduce the time needed for treatment. In this review we focus solely on drugs currently used, or under investigation, for nebulization in adult patients; basically bronchodilators, inhaled steroids, antibiotics, antifungals, mucolytics and others such as anticoagulants, prostanoids and lidocaine.

  17. Another slow year

    SciTech Connect

    Not Available

    1987-08-01

    This article is a review of the petroleum activity in the Middle East. The article is accompanied by a detailed color map showing the activity in the area. Highlights of the article include the fact that Saudi Arabia's drilling and development activity has sunk to its lowest level in many years. The article also points out that discoveries are increasing production in North and South Yemen as well as in Syria. The article also highlights the fact that Qatar is beginning work on its massive North gas field in the Gulf. Also attention is paid to the effects of the Iranian and Iraq war on each other's oil and gas activities. The article also mentions the drilling activity of Dubai and Oman.

  18. Twenty Years of KSHV

    PubMed Central

    Chang, Yuan; Moore, Patrick

    2014-01-01

    Twenty years ago, Kaposi’s sarcoma (KS) was the oncologic counterpart to Winston Churchill’s Russia: a riddle, wrapped in a mystery, inside an enigma. First described by Moritz Kaposi in 1872, who reported it to be an aggressive skin tumor, KS became known over the next century as a slow-growing tumor of elderly men—in fact, most KS patients were expected to die with the tumor rather than from it. Nevertheless, the course and manifestations of the disease varied widely in different clinical contexts. The puzzle of KS came to the forefront as a harbinger of the AIDS epidemic. The articles in this issue of Viruses recount progress made in understanding Kaposi’s sarcoma herpesvirus (KSHV) since its initial description in 1994. PMID:25386844

  19. A year of astronomy

    NASA Astrophysics Data System (ADS)

    Dench, Paul; Htoon, Sein

    2009-03-01

    The opening sentence of your news story "Let the global astronomy celebrations begin" (January pp12-13) implies that the prime anchor for the International Year of Astronomy (IYA2009) is the efforts of Galileo Galilei. If this is the case, then we must be careful how much credit we give him. A more accurate opening sentence would have referred to the first publication of the use of an astronomical telescope by Galileo, following its first known use by the British scientist Thomas Harriot, whose diaries include sketches of the Moon made on 26 July 1609 - a few months before Galileo. Unfortunately, Harriot never published his observations; an article by Allan Chapman in Astronomy and Geophysics (2009 50 1.27) describes the events in more detail.

  20. A Productive YORP Year

    NASA Astrophysics Data System (ADS)

    Margot, Jean-Luc

    2007-10-01

    Although the implications of the Yarkovsky-O'Keefe-Radzievskii-Paddack (YORP) effect have been widely perceived as important for asteroid dynamics [1], the lack of a direct YORP detection was troublesome, until recently. Last year at this meeting a manuscript describing a robust YORP detection was circulated and discussed informally. Two publications emerged [2,3]. A change in the spin rate of asteroid (54509) was found in [2] by measuring the rate of change in lightcurve periods, and in [3] by a different analysis of the same data. The amplitude of the observed acceleration was shown to be in rough agreement with YORP predictions [3] and asteroid (54509) received the name YORP. Shortly after the meeting work started on the detection of YORP on (1862) Apollo [4]. A third YORP detection on asteroid (25143) Itokawa is now in hand [5]. YORP seems pervasive and significant enough that it complicates shape inversion efforts when data sets span several years, especially for small asteroids. Since the last meeting, work has continued on improving the formulation and modeling of the YORP effect acting on single asteroids [6], on examining the possible formation of binaries with YORP [7,8], and on understanding the effect of YORP in the best characterized binaries [9,10]. A summary of recent advances in the field will be presented at the meeting. [1] W. Bottke et al., AREPS 34, 2006. [2] S. C. Lowry et al., Science 316, 2007. [3] P. A. Taylor et al., Science 316, 2007. [4] M. Kaasalainen et al., Nature 446, 2007. [5] K. Kitazato et al., A&A, submitted. [6] D. Scheeres et al., Icarus 188, 2007. [7] M. Cuk, ApJL 659, 2007. [8] P. Pravec and A. Harris, Icarus, in press. [9] S. Ostro et al., Science 314, 2006. [10] D. Scheeres et al., Science 314, 2006.

  1. Ten years of PAMELA

    NASA Astrophysics Data System (ADS)

    Spillantini, Piero

    2016-07-01

    Pamela experiment has been designed as a cosmic ray observatory at 1 AU, dedicated to the precise and high statistics study of CR fluxes on a three decades energy range, form a few tens MeV up to several hundred GeV region. It is the last step of the 'Russian-Italian Mission' (RIM) program born in 1992 between several Italian and Russian institutes and with the participation of the Royal Institute of Technology of Stockholm (Sweden) and the Siegen University (German). Launched the 16 June 2006 from Baikonur cosmodrome on board of the Resurs-DK1 Russian satellite by a Soyuz rocket in an elliptical (350-610 km) quasi polar orbit (70° inclination) it was activated on 21 June 2006, afterword has been in a continuous data taking mode for ten years. The Pamela program pays particular attention to the study of particles (protons and electrons) and antiparticles (antiprotons and positrons) energy spectra. It also includes search for possible signals of dark matter annihilation, search for primordial antimatter (antihelium), search for new Matter in the Universe (Strangelets?), study of cosmic-ray propagation, solar physics and solar modulation, terrestrial magnetosphere. This program is made possible thanks to the outstanding performance of the instrument, the low energy threshold, the quasi-polar orbit, the 10 years duration of the observation. Protons and helium nuclei are the most abundant components of the cosmic radiation and the precise measurements of their fluxes allow understanding the acceleration and propagation of cosmic rays in the Galaxy. Their spectral shapes cannot be well described by a single power law: at 230-240 GV they exhibit an abrupt spectral hardening. They challenge the current paradigm of cosmic-ray acceleration in supernova remnants followed by diffusive propagation in the Galaxy. Of paramount importance is the discover of the anomalous increase of the positron flux at energies higher that 50 GeV (the so called 'Pamela anomaly'). The review of

  2. EDITORIAL: Happy New Year!

    NASA Astrophysics Data System (ADS)

    Yang, Xue-ming

    2006-02-01

    As many of you are aware that Chinese science is at the crucial stage of development. We are now seeing more and more high quality works being produced by Chinese scientists working in China. However, high quality scientific works are rarely published in Chinese scientific journals so far. Therefore, the development of scientific journals publishing in China now becomes a more and more important indication of the science development in China. In the development of the chemical physics research field in China, the Chinese Journal of Chemical Physics (CJCP) has made significant contributions in the past 18 years. Since CJCP is primarily a Journal published in Chinese previously, its impact in the international scientific community has been quite limited. At this moment, we believe CJCP should increase its impact in the international community. We believe that making CJCP an English journal is a crucial step to increase its influence internationally. Therefore, upon the recommendation of senior editorial members, we now change CJCP into an full English journal from this issue on. We have also formed a high quality editorial board to help the editorial matters in CJCP, and a prestigious advisory board to advise us of the future development. I am very honored to be selected as the new Editor-in-Chief for the next four years. I hope by the end of my term, the impact of this journal is significantly improved through the efforts of our editorial team. Building a high quality scientific journal is not an easy task. I hope that every member of our chemical physics community can provide strong support to this journal by sending your high quality research papers in the future. We are also thinking about adding new sections of this journal to attract more readers. With the support of our community, I am confident that we can make this journal a more successful one. Here, I want to take this opportunity to thank the great leadership provided by the Editor-in-Chief since the

  3. Longitudinal posturography and rotational testing in children 3-9 years of age: Normative data

    PubMed Central

    Casselbrant, Margaretha L.; Mandel, Ellen M.; Sparto, Patrick J; Perera, Subashan; Redfern, Mark S.; Fall, Patricia A.; Furman, Joseph M.

    2010-01-01

    Objective To obtain normative longitudinal vestibulo-ocular and balance test data in children from ages 3 to 9 with normal middle-ear status. Study Design Prospective, longitudinal cohort Setting Tertiary care pediatric hospital Subjects and Methods Three-year-old children were entered and tested yearly. Subjects underwent earth vertical axis rotation testing using sinusoidal and constant velocity stimuli and performed the Sensory Organization Test. Results One hundred forty-eight children were entered and usable data were collected on 127 children. A linear increase in the vestibulo-ocular reflex gain as children aged was found, without a change in the phase of the response. An age-related linear increase in Equilibrium Scores, indicating reduced postural sway, was also observed. Conclusion These normative data can be used in the evaluation of dizziness and balance disorders in children. PMID:20416461

  4. Clinical Performance of the ASR and ReCap Resurfacing Implants—7 Years Follow-Up.

    PubMed

    Borgwardt, Arne; Borgwardt, Lotte; Borgwardt, Lise; Zerahn, Bo; Fabricius, Sandra D; Ribel-Madsen, Søren

    2015-06-01

    We perform a non-randomized, consecutive pilot study on the ASR and ReCap resurfacing hip implants and have completed 7 years follow-up. Forty-six non-osteoporotic patients with hip osteoarthritis and anatomical conditions suitable for resurfacing were divided into 2 equal groups and operated sequentially, starting with the ASR implants. Sixteen patients operated with ASR and 19 patients with ReCap have been followed-up. There were no significant differences between the two groups preoperatively as to physical function, pain, or femoral BMD. The serum concentrations of cobalt and chromium were higher in the ASR group from 1/2 to 7 years postoperatively. Five of 16 ASR implants have been revised, and none of the ReCap implants. BMD below the femoral component increased in both groups.

  5. Neuroticism and Extraversion in Youth Predict Mental Wellbeing and Life Satisfaction 40 Years Later.

    PubMed

    Gale, Catharine R; Booth, Tom; Mõttus, René; Kuh, Diana; Deary, Ian J

    2013-12-01

    Neuroticism and Extraversion are linked with current wellbeing, but it is unclear whether these traits in youth predict wellbeing decades later. We applied structural equation modelling to data from 4583 people from the MRC National Survey of Health and Development. We examined the effects of Neuroticism and Extraversion at ages 16 and 26 years on mental wellbeing and life satisfaction at age 60-64 and explored the mediating roles of psychological and physical health. Extraversion had direct, positive effects on both measures of wellbeing. The impact of Neuroticism on both wellbeing and life satisfaction was largely indirect through susceptibility to psychological distress and physical health problems. Personality dispositions in youth have enduring influence on wellbeing assessed about forty years later.

  6. Predicting Reading and Spelling Disorders: A 4-Year Prospective Cohort Study

    PubMed Central

    Bigozzi, Lucia; Tarchi, Christian; Caudek, Corrado; Pinto, Giuliana

    2016-01-01

    In this 4-year prospective cohort study, children with a reading and spelling disorder, children with a spelling impairment, and children without a reading and/or spelling disorder (control group) in a transparent orthography were identified in third grade, and their emergent literacy performances in kindergarten compared retrospectively. Six hundred and forty-two Italian children participated. This cohort was followed from the last year of kindergarten to third grade. In kindergarten, the children were assessed in phonological awareness, conceptual knowledge of writing systems and textual competence. In third grade, 18 children with a reading and spelling impairment and 13 children with a spelling impairment were identified. Overall, conceptual knowledge of the writing system was the only statistically significant predictor of the clinical samples. No differences were found between the two clinical samples. PMID:27014145

  7. Predicting Reading and Spelling Disorders: A 4-Year Prospective Cohort Study.

    PubMed

    Bigozzi, Lucia; Tarchi, Christian; Caudek, Corrado; Pinto, Giuliana

    2016-01-01

    In this 4-year prospective cohort study, children with a reading and spelling disorder, children with a spelling impairment, and children without a reading and/or spelling disorder (control group) in a transparent orthography were identified in third grade, and their emergent literacy performances in kindergarten compared retrospectively. Six hundred and forty-two Italian children participated. This cohort was followed from the last year of kindergarten to third grade. In kindergarten, the children were assessed in phonological awareness, conceptual knowledge of writing systems and textual competence. In third grade, 18 children with a reading and spelling impairment and 13 children with a spelling impairment were identified. Overall, conceptual knowledge of the writing system was the only statistically significant predictor of the clinical samples. No differences were found between the two clinical samples.

  8. Neuroticism and Extraversion in Youth Predict Mental Wellbeing and Life Satisfaction 40 Years Later

    PubMed Central

    Gale, Catharine R; Booth, Tom; Mõttus, René; Kuh, Diana; Deary, Ian J

    2014-01-01

    Neuroticism and Extraversion are linked with current wellbeing, but it is unclear whether these traits in youth predict wellbeing decades later. We applied structural equation modelling to data from 4583 people from the MRC National Survey of Health and Development. We examined the effects of Neuroticism and Extraversion at ages 16 and 26 years on mental wellbeing and life satisfaction at age 60-64 and explored the mediating roles of psychological and physical health. Extraversion had direct, positive effects on both measures of wellbeing. The impact of Neuroticism on both wellbeing and life satisfaction was largely indirect through susceptibility to psychological distress and physical health problems. Personality dispositions in youth have enduring influence on wellbeing assessed about forty years later. PMID:24563560

  9. Twenty Years at ESO

    NASA Astrophysics Data System (ADS)

    Woltjer, L.

    1982-12-01

    On the 5th of October 1962, the ESO Convention was signed in Paris by representatives of Belgium, France, the Federal Republic of Germany, the Netherlands and Sweden. More than a year later, on the 17th of January 1964, the Convention went into effect, following parliamentary ratification in the required majority of countries. In 1967, Denmark also joined. In the early days (partly before the formalities were completed), site surveys were made which led to the choice of La Silla as the observatory location, and work was started on the La Silla infrastructure and on the Schmidt telescope and the 3.6 m telescope. Some other telescopes were ordered from industry. After it was realized that ESO did not have the necessary (technical) management capabilities to bring all its projects to a successful completion, discussions took place with CERN which led in 1970 to the founding of the T(elescope) P(roject) Division in Geneva, partly staffed with CERN personnel. As a result, the 3.6 m telescope was completed in 1976.

  10. Twenty years of dendrotoxins.

    PubMed

    Harvey, A L

    2001-01-01

    Dendrotoxins are small proteins that were isolated 20 years ago from mamba (Dendroaspis) snake venoms (Harvey, A.L., Karlsson, E., 1980. Dendrotoxin from the venom of the green mamba, Dendroaspis angusticeps: a neurotoxin that enhances acetylcholine release at neuromuscular junctions. Naunyn-Schmiedebergs Arch. Pharmacol. 312, 1-6.). Subsequently, a family of related proteins was found in mamba venoms and shown to be homologous to Kunitz-type serine protease inhibitors, such as aprotinin. The dendrotoxins contain 57-60 amino acid residues cross-linked by three disulphide bridges. The dendrotoxins have little or no anti-protease activity, but they were demonstrated to block particular subtypes of voltage-dependent potassium channels in neurons. Studies with cloned K(+) channels indicate that alpha-dendrotoxin from green mamba Dendroaspis angusticeps blocks Kv1.1, Kv1.2 and Kv1.6 channels in the nanomolar range, whereas toxin K from the black mamba Dendroaspis polylepis preferentially blocks Kv1.1 channels. Structural analogues of dendrotoxins have helped to define the molecular recognition properties of different types of K(+) channels, and radiolabelled dendrotoxins have also been useful in helping to discover toxins from other sources that bind to K(+) channels. Because dendrotoxins are useful markers of subtypes of K(+) channels in vivo, dendrotoxins have become widely used as probes for studying the function of K(+) channels in physiology and pathophysiology.

  11. CRESP at one year

    SciTech Connect

    Powers, C.; Goldstein, B.; Omenn, G.S.

    1996-12-31

    The Consortium for Risk Evaluation with Stakeholder Participation (CRESP) is a university-based consortium led by the Environmental and Occupational Health Sciences Institute (EOHSI) in New Jersey and the School of Public Health and Community Medicine of the University of Washington (UW) in Seattle. Designed to be an independent, outside integrating institution on risk, CRESP was selected in DOE`s 1994 Notice of Proposed Interest competition and awarded a five-year cooperative agreement on March 13, 1995. CRESP`s mission is to inform protective and cost-effective cleanup and enhance stakeholder understanding of the nation`s nuclear weapons production waste sites by improving the scientific and technical basis of environmental management decisions. Eight separate task groups, drawn from the two universities, have been established to organize research and operations for CRESP. One senior researcher from one of the two schools directs the overall CRESP effort for that task group. Each university is currently focusing its site-specific research on issues and concerns raised at either Hanford or Savannah River. CRESP`s Independent Peer Review group, peer reviews CRESP`s work and has agreed to provide a review of major risk-evaluation processes within Environmental Management at DOE.

  12. [Sixty years of autism].

    PubMed

    van Berckelaer-Onnes, I A

    2004-05-22

    The concept of autism has been broadened the last few years from 'early infantile autism' to 'an autistic spectrum'. Autism and related contact disorders are grouped together under 'pervasive developmental disorders' or 'autistic spectrum disorders'. The autistic disorder, Asperger's syndrome, pervasive developmental disorder not otherwise specified (PDD-NOS), Rett's disorder and the childhood disintegrative disorder all belong to this group. People with an autistic spectrum disorder have severe difficulties in the integration of perceived stimuli into a meaningful entity. More than two-thirds of the people with the autistic disorder (classical autism) are also mentally retarded. Although autism can still only be diagnosed at the behavioural level, there is considerable consensus regarding an underlying organic aetiology. Autism is clearly a multifactorial condition. Autism cannot be cured, but adequate intervention can significantly improve the quality of life of people with this disorder. Diagnosis and intervention are highly interrelated. In the intervention, a distinction is made between family-oriented and child-oriented strategies. Augmentative communication plays a key role in the treatment. People with autism need a lot of structure, clarity and predictability, also when they have become adults.

  13. Two-year follow-up of the Collision Auto Repair Safety Study (CARSS).

    PubMed

    Bejan, Anca; Parker, David L; Brosseau, Lisa M; Xi, Min; Skan, Maryellen

    2015-06-01

    This paper presents an evaluation of the sustainability of health and safety improvements in small auto collision shops 1 year after the implementation of a year-long targeted intervention. During the first year (active phase), owners received quarterly phone calls, written reminders, safety newsletters, and access to online services and in-person assistance with creating safety programs and respirator fit testing. During the second year (passive phase), owners received up to three postcard reminders regarding the availability of free health and safety resources. Forty-five shops received an evaluation at baseline and at the end of the first year (Y1). Of these, 33 were evaluated at the end of the second year (Y2), using the same 92-item assessment tool. At Y1, investigators found that between 70 and 81% of the evaluated items were adequate in each business (mean = 73% items, SD = 11%). At Y2, between 63 and 89% of items were deemed adequate (mean = 73% items, SD = 9.5%). Three safety areas demonstrated statistically significant (P < 0.05) changes: compressed gasses (8% improvement), personal protective equipment (7% improvement), and respiratory protection (6% decline). The number of postcard reminders sent to each business did not affect the degree to which shops maintained safety improvements made during the first year of the intervention. However, businesses that received more postcards were more likely to request assistance services than those receiving fewer.

  14. Two-Year Follow-up of the Collision Auto Repair Safety Study (CARSS)

    PubMed Central

    Bejan, Anca; Parker, David L.; Brosseau, Lisa M.; Xi, Min; Skan, Maryellen

    2015-01-01

    This paper presents an evaluation of the sustainability of health and safety improvements in small auto collision shops 1 year after the implementation of a year-long targeted intervention. During the first year (active phase), owners received quarterly phone calls, written reminders, safety newsletters, and access to online services and in-person assistance with creating safety programs and respirator fit testing. During the second year (passive phase), owners received up to three postcard reminders regarding the availability of free health and safety resources. Forty-five shops received an evaluation at baseline and at the end of the first year (Y1). Of these, 33 were evaluated at the end of the second year (Y2), using the same 92-item assessment tool. At Y1, investigators found that between 70 and 81% of the evaluated items were adequate in each business (mean = 73% items, SD = 11%). At Y2, between 63 and 89% of items were deemed adequate (mean = 73% items, SD = 9.5%). Three safety areas demonstrated statistically significant (P < 0.05) changes: compressed gasses (8% improvement), personal protective equipment (7% improvement), and respiratory protection (6% decline). The number of postcard reminders sent to each business did not affect the degree to which shops maintained safety improvements made during the first year of the intervention. However, businesses that received more postcards were more likely to request assistance services than those receiving fewer. PMID:25539646

  15. YEAR 2 BIOMASS UTILIZATION

    SciTech Connect

    Christopher J. Zygarlicke

    2004-11-01

    This Energy & Environmental Research Center (EERC) Year 2 Biomass Utilization Final Technical Report summarizes multiple projects in biopower or bioenergy, transportation biofuels, and bioproducts. A prototype of a novel advanced power system, termed the high-temperature air furnace (HITAF), was tested for performance while converting biomass and coal blends to energy. Three biomass fuels--wood residue or hog fuel, corn stover, and switchgrass--and Wyoming subbituminous coal were acquired for combustion tests in the 3-million-Btu/hr system. Blend levels were 20% biomass--80% coal on a heat basis. Hog fuel was prepared for the upcoming combustion test by air-drying and processing through a hammer mill and screen. A K-Tron biomass feeder capable of operating in both gravimetric and volumetric modes was selected as the HITAF feed system. Two oxide dispersion-strengthened (ODS) alloys that would be used in the HITAF high-temperature heat exchanger were tested for slag corrosion rates. An alumina layer formed on one particular alloy, which was more corrosion-resistant than a chromia layer that formed on the other alloy. Research activities were completed in the development of an atmospheric pressure, fluidized-bed pyrolysis-type system called the controlled spontaneous reactor (CSR), which is used to process and condition biomass. Tree trimmings were physically and chemically altered by the CSR process, resulting in a fuel that was very suitable for feeding into a coal combustion or gasification system with little or no feed system modifications required. Experimental procedures were successful for producing hydrogen from biomass using the bacteria Thermotoga, a deep-ocean thermal vent organism. Analytical procedures for hydrogen were evaluated, a gas chromatography (GC) method was derived for measuring hydrogen yields, and adaptation culturing and protocols for mutagenesis were initiated to better develop strains that can use biomass cellulose. Fly ash derived from

  16. Marijuana: A Fifty-Year Personal Addiction Medicine Perspective.

    PubMed

    Smith, David E

    2016-01-01

    As of September 2015, the cultivation, possession, and/or use of marijuana is illegal under U.S. federal law as a Schedule I narcotic; however, it is legal in four states and Washington, D.C. Forty-six states allow some form of medicinal marijuana or decriminalization. Marijuana has been used medicinally for thousands of years; Marijuana's regulation by law enforcement in the U.S., rather than the medical community, led to an almost complete halt to academic and scientific research after the 1930s. The late 1960s saw an upsurge in recreational marijuana use by middle-class youth, the majority of whom experienced minimal adverse effects aside from arrest and attendant legal complications. Since the mid-1990s, the use of medicinal marijuana for certain conditions has gained increasing acceptance. Stronger strains and formulations of marijuana pose a risk to the developing brains of adolescents. Within the addiction medicine community, there is currently no consensus on marijuana. In the East, the feeling is primarily that marijuana continue to be proscribed. In the West, where clinicians must face the realities of medicalization, decriminalization, and/or legalization, as well as widespread recreational use, there is more of a movement to minimize adverse effects, particularly on youth.

  17. Fleet Compliance Annual Report: Model Year 2015, Fiscal Year 2016

    SciTech Connect

    2016-12-01

    The U.S. Department of Energy (DOE) regulates covered state government and alternative fuel provider fleets, pursuant to the Energy Policy Act of 1992 (EPAct), as amended. This report details compliance for model year 2015, fiscal year 2016.

  18. WHO Expert Committee on Biological Standardization. Forty-sixth Report.

    PubMed

    1998-01-01

    This report presents the recommendations of a WHO Expert Committee commissioned to coordinate activities leading to the adoption of international requirements for the production and control of vaccines and other biologicals and the establishment of international biological reference materials. The report starts with a discussion of general issues brought to the Committee's attention and provides information on the status and development of reference materials for various antibiotics, antibodies, antigens, blood products, cytokines, endocrinological and related substances and toxins. The second part of the report, of particular relevance to manufacturers and national control authorities, contains the revised list of laboratories approved by WHO for the production of yellow fever vaccine, revised requirements for yellow fever vaccine, an amendment to the General Requirements for the Sterility of Biological Substances, and a summary protocol for the batch release of virus vaccines.

  19. Condensed Matter Physics in Colombia is in its forties

    NASA Astrophysics Data System (ADS)

    Camacho, Angela

    2015-03-01

    Physics in Colombia started to develop in the 70's as a research part of basic sciences with the acquisition, at that time, of large research equipments such as x-rays and EPR. Experimental work was soon supplemented by theoretical investigations, which led to the formation of research groups in condensed matter. In the early 80's existed such groups in five universities. In this report we present, after a short history of the main steps that guided the initial research subjects, the major areas already developed and the minor research groups that are in the stage of consolidation. Currently this type of work is done at least in 20 universities. We also show the actual numbers of researchers, publications, PhD students and laboratories discriminated in gender to complete an overview of Condensed Matter Physics in Colombia. Finally, we present a short review of the main theoretical issues that have been worked in the last decade focusing on low dimensional systems, their structural and optical properties

  20. Forty Meters from Entry to Victoria Crater (Vertical)

    NASA Technical Reports Server (NTRS)

    2007-01-01

    NASA's Mars Exploration Rover Opportunity used its navigation camera during the rover's 1,278th Martian day, or sol, (Aug. 28, 2007) to take the images combined into this view. The rover was perched at the lip of Victoria Crater, which is about 800 meters (one-half mile) in diameter.

    After assessment of possible routes for Opportunity to descend into the crater, the rover team selected a site farther to the right along the rim. That selected entry point lies near the ripple of bright soil visible just outside the crater near the top center of this scene. The driving distance for Opportunity from the Sol 1,278 viewpoint to the selected entry point is about 40 meters (about 130 feet).

    This view is presented as a vertical projection with geometric seam correction.

  1. Forty Meters from Entry to Victoria Crater (Stereo)

    NASA Technical Reports Server (NTRS)

    2007-01-01

    [figure removed for brevity, see original site] Left-eye view of a color stereo pair for PIA09972 [figure removed for brevity, see original site] Right-eye view of a color stereo pair for PIA09972

    NASA's Mars Exploration Rover Opportunity used its navigation camera during the rover's 1,278th Martian day, or sol, (Aug. 28, 2007) to take the images combined into this stereo view. The rover was perched at the lip of Victoria Crater, which is about 800 meters (one-half mile) in diameter.

    After assessment of possible routes for Opportunity to descend into the crater, the rover team selected a site farther to the right along the rim. That selected entry point lies near the ripple of bright soil visible just outside the crater near the top center of this scene. The driving distance for Opportunity from the Sol 1,278 viewpoint to the selected entry point is about 40 meters (about 130 feet).

    This view combines a stereo pair and appears three-dimensional when seen through blue-red glasses. It is presented as a cylindrical-perspective projection with geometric seam correction.

  2. Forty Meters from Entry to Victoria Crater (Polar)

    NASA Technical Reports Server (NTRS)

    2007-01-01

    NASA's Mars Exploration Rover Opportunity used its navigation camera during the rover's 1,278th Martian day, or sol, (Aug. 28, 2007) to take the images combined into this view. The rover was perched at the lip of Victoria Crater, which is about 800 meters (one-half mile) in diameter.

    After assessment of possible routes for Opportunity to descend into the crater, the rover team selected a site farther to the right along the rim. That selected entry point lies near the ripple of bright soil visible just outside the crater near the top center of this scene. The driving distance for Opportunity from the Sol 1,278 viewpoint to the selected entry point is about 40 meters (about 130 feet).

    This view is presented as a polar projection with geometric seam correction.

  3. Forty Rural Schools: A Study of School Effectiveness.

    ERIC Educational Resources Information Center

    Talbert, Elmer Gene; And Others

    A comparison of Middle Tennessee Rural (MTR) schools with the national sample of schools included in Kappa Delta Pi's Good Schools Project (GSP) focused on the areas of curriculum perspectives, goal attainment, classroom practices, interpersonal relations, commitment, discipline and safety, support services and facilities, and decision making. The…

  4. Mental Health and Teacher Education. Forty-Sixth Yearbook, 1967.

    ERIC Educational Resources Information Center

    Association for Student Teaching, Washington, DC.

    Ten papers constitute the major portion of this book: "The Classroom Teacher, Mental Health, and Learning," Robert E. Bills; "The Development of Selected Aspects of the Mental Health Movement in Teacher Education," Ralph H. Ojemann; "What Psychology Has To Offer to Teacher Education," Carl R. Rogers; "Conceptual…

  5. A Different New Year: Chinese New Year, Teacher's Handbook.

    ERIC Educational Resources Information Center

    Huang, Joe

    This booklet provides: (1) background information on the traditional celebration of the Chinese New Year and on the Chinese New Year Festival as celebrated in the United States; (2) a three day lesson plan which focuses, respectively, on the Chinese New Year Festival in San Francisco, a field trip to San Francisco's Chinatown, and the Chinese…

  6. Caries increment in children and urinary catecholamines: findings at one-year.

    PubMed

    Vanderas, A P; Manetas, K; Papagiannoulis, L

    2000-01-01

    This one-year follow-up study investigates the relationship between urinary catecholamine levels and dental caries increment in 314 children, boys and girls, ages six to eight years. Dental caries was recorded clinically and radiographically and oral hygiene was evaluated by recording the dental plaque. A 24-hour urine sample was collected for each subject, in a year interval, and a representative sample was analyzed by the HPLC technique to assay the catecholamine content. Socioeconomic factors such as parental age, education, and profession were recorded by a questionnaire distributed to the parents. Of the examined children, forty-four (16 boys and 28 girls) did not develop new dental caries and constituted the Caries-Free group. Two New Caries groups, A and B, of forty-four children each (16 boys and 28 girls) were matched by age and sex. Differences were tested in the quantitative and qualitative data by the paired t-test and the chi 2 test, respectively, while a regression analysis was applied to measure the effects of norepinephrine and dopamine on epinephrine. The logistic multiple-regression analysis was used to test, in the entire population, the impact of catecholamines and other related factors on the probability of a subject's developing new dental caries. The 95 percent probability was used. The results showed statistically significant differences in epinephrine and norepinephrine values between Caries-Free and New Caries group A in both examinations. Also, significant differences were found between Caries-Free and New Caries group B in epinephrine and norepinephrine at the first examination, while at the second examination the difference was significant only in epinephrine. The data provide evidence, therefore, that an emotionally stressful state can be an etiologic factor of dental caries.

  7. Social Development: 1 Year Olds

    MedlinePlus

    ... Stages Listen Español Text Size Email Print Share Social Development: 1 Year Olds Page Content Article Body During his second year, your toddler will develop a very specific image of his social world, friends, and acquaintances. He ...

  8. Your Child's Development: 3 Years

    MedlinePlus

    ... Feeding Your 1- to 2-Year-Old Your Child’s Development: 3 Years KidsHealth > For Parents > Your Child’s Development: 3 Years A A A Kids this age ... but certain signs could indicate a delay in development. Talk to your doctor if your child: doesn't speak, or can't speak in ...

  9. Your Child's Development: 3 Years

    MedlinePlus

    ... Feeding Your 1- to 2-Year-Old Your Child’s Development: 3 Years KidsHealth > For Parents > Your Child’s Development: 3 Years Print A A A en español ... but certain signs could indicate a delay in development. Talk to your doctor if your child: doesn't speak, or can't speak in ...

  10. Assessment and 2-Year Institutions.

    ERIC Educational Resources Information Center

    Bradley, Jama L.; And Others

    1994-01-01

    Describes a national study of the current availability and use of commercially and institutionally developed educational assessment instruments. Indicates that two-year institutions reported less activity than four-year institutions in assessing the major fields of study but that 77% of all two-year institutions assessed basic skills. (MAB)

  11. Report of twelve years experience in open study of Skinner herpes simplex vaccine towards prevention of herpes genitalis.

    PubMed

    Skinner, G R; Fink, C; Melling, J; Wiblin, C; Thornton, B; Hallworth, J; Gardner, W; McLeish, P; Hartley, C; Buchan, A

    1992-01-01

    Three hundred and forty-seven subjects at risk for herpes genitalis were vaccinated with Skinner vaccine, NFUAc.HSV1.(S-MRC5), and were followed for an average duration of 2 years representing a total consortship of 664.4 years. Based on survey information obtained during this consortship, there were estimated to be 3076 recurrences which summated to 3.5 years total duration of disease and comprised at least 6794 lesions; there were an estimated 51997 episodes of intercourse including at least 241 episodes of unprotected intercourse in the presence of herpetic lesions. The rate of contraction of herpes genitalis was 6 of 54 consorts (11.1%) who received one vaccination and 7 of 293 (2.4%) who received two, three of four vaccinations. There was no evidence of physical or psychological side effects from vaccination.

  12. Minimally invasive aortic valve replacement: 12-year single center experience

    PubMed Central

    Solinas, Marco; Farneti, Pier Andrea; Cerillo, Alfredo Giuseppe; Kallushi, Enkel; Santarelli, Filippo; Glauber, Mattia

    2015-01-01

    Background This study reports the single center experience on minimally invasive aortic valve replacement (MIAVR), performed through a right anterior minithoracotomy or ministernotomy (MS). Methods Eight hundred and fifty-three patients, who underwent MIAVR from 2002 to 2014, were retrospectively analyzed. Survival was evaluated using the Kaplan-Meier method. The Cox multivariable proportional hazards regression model was developed to identify independent predictors of follow-up mortality. Results Median age was 73.8, and 405 (47.5%) of patients were female. The overall 30-day mortality was 1.9%. Four hundred and forty-three (51.9%) and 368 (43.1%) patients received biological and sutureless prostheses, respectively. Median cardiopulmonary bypass time and aortic cross-clamping time were 108 and 75 minutes, respectively. Nineteen (2.2%) cases required conversion to full median sternotomy. Thirty-seven (4.3%) patients required re-exploration for bleeding. Perioperative stroke occurred in 15 (1.8%) patients, while transient ischemic attack occurred postoperative in 11 (1.3%). New onset atrial fibrillation was reported for 243 (28.5%) patients. After a median follow-up of 29.1 months (2,676.0 patient-years), survival rates at 1 and 5 years were 96%±1% and 80%±3%, respectively. Cox multivariable analysis showed that advanced age, history of cardiac arrhythmia, preoperative chronic renal failure, MS approach, prolonged mechanical ventilation and hospital stay as well as wound revision were associated with higher mortality. Conclusions MIAVR via both approaches is safe and feasible with excellent outcomes, and is associated with low conversion rate and low perioperative morbidity. Long term survival is at least comparable to that reported for conventional sternotomy AVR. PMID:25870812

  13. Electron microscopy of myocardial tissue. A nine year review

    PubMed Central

    Mudhar, H; Wagner, B; Suvarna, S

    2001-01-01

    Aim—To review and reassess the role of this department's experience with routine electron microscopy of myocardial tissues. Methods—A nine year series of myocardial samples that underwent electron microscopy analysis were audited. Fifty nine samples were derived from 46 male and 13 female subjects with an age range of 15–90 years (mean, 50.6). Forty two samples were endomyocardial specimens, with 13 being derived from explanted hearts, and four from necropsies. Two cases were from transplanted hearts. These were all reviewed in a blinded fashion, by all three authors separately, in terms of the myocardium at the ultrastructural level. Subsequently, the interpretations/diagnoses were cross compared with the light microscopy and clinical data results. Results—Four cases of amyloid were identified; in addition, one case of granulomatous inflammation and one case of basophilic degeneration were seen, although all these had been evident on light microscopy. One case of possible mitochondrial myopathy was found. A total of 18 cases revealed changes of a presumed non-specific type including glycogen, lipid, and mitochondrial accumulations. Varying types of degeneration involving myofibres were seen together with variations in interstitial fibrosis and occasional cytoplasmic inclusions. Conclusion—Overall, although interesting, the electron microscopy of myocardial tissue added little to the understanding of the patient's disease, with only one case showing changes not found at light microscopy or with other investigations. Further study might shed light on the "non-specific" ultrastructural findings encountered. Key Words: electron microscopy • myocardial tissue • mitochondrial myopathy PMID:11304852

  14. Pharmaceuticals: pharmaceutical cost controls--2005. End of Year Issue Brief.

    PubMed

    Seay, Melicia; Varma, Priya

    2005-12-31

    The enactment of the Omnibus Budget Reconciliation Act of 1990 (OBRA '90) gave states the option of offering pharmaceutical benefits within their Medicaid programs. But the law placed restrictions on states' flexibility to control what prescriptions they would cover and required the states to reimburse outpatient prescription drugs from manufacturers that signed rebate agreements with the U.S. Department of Health and Human Services. Forty-nine states--Arizona is excluded, based on its program structure--and the District of Columbia currently offer prescription drug coverage under the Medicaid Drug Rebate Program. During the past four years, states all over the country have been plagued with revenue shortfalls in their state Medicaid budgets. While the fiscal situation improved for most states in the 2004 legislative session, many states still face budget pressures in 2005. Compounding existing budget pressures are threats from the Bush Administration to shift increased costs of the Medicaid program on to the states. All things considered, the economic pressure of funding Medicaid is at the top of legislative agendas in 2005. As in previous years, states are attempting to reduce costs to their Medicaid programs by seeking savings in their pharmaceutical programs. Prescription drug costs are highly attributed as a contributing factor to the fiscal climate of state Medicaid programs. Currently, prescription drug spending outpaces that of every other category of health care and drug prices are rising faster than inflation. In response, states are instituting a variety of pharmaceutical cost control measures such as creating preferred drug lists (PDLs), negotiating supplemental rebates, forming bulk purchasing pools, promoting generic drug substitution and implementing price controls. As prescription drug cost containment tools have gained acceptance and momentum, they continue to be controversial. This issue brief explores the debate, history, methodology, utilization

  15. The treatment of acute traumatic rupture of the aorta: a 10-year experience.

    PubMed Central

    Kirsh, M M; Behrendt, D M; Orringer, M B; Gago, O; Gray, L A; Mills, L J; Walter, J F; Sloan, H

    1976-01-01

    Forty-three patients with aortic rupture secondardy to blunt trauma have been treated at the University of Micigan within the past 10 years with an overall salvage rate of 70%. The diagnosis should be suspected in anyone who has sustained a high speed decelerating injury, if the chest roentgenogram shows media-stinal widening, whether or not there is hypertension of the upper extremities; systolic murmur, or external evidence of chest injury. Aortography should be employed to confirm the diagnosis and to determine the site or sites of rupture. Repair of the lesion should be undertaken as soon as possible and takes priority in most instances over associated injuries. Repair in almost all cases can be accomplished safely and quickly using a bypass shunt without the aid of extracorporeal circulation. Images Fig. 1. Fig. 2. PMID:962399

  16. A statement on abortion by 100 professors of obstetrics: 40 years later.

    PubMed

    2013-09-01

    In this Journal in 1972, 100 leaders in obstetrics and gynecology published a compelling statement that recognized the legalization of abortion in several states and anticipated the 1973 Supreme Court decision in Roe v Wade. They projected the numbers of legal abortions that likely would be required by women in the United States and described the role of the teaching hospital in meeting that responsibility. They wrote to express their concern for women's health in a new legal and medical era of reproductive control and to define the responsibilities of academic obstetrician-gynecologists. Forty years later, 100 professors examine the statement of their predecessors in light of medical advances and legal changes and suggest a further course of action for obstetrician gynecologists.

  17. A statement on abortion by 100 professors of obstetrics: 40 years later.

    PubMed

    2013-10-01

    In this Journal in 1972, 100 leaders in obstetrics and gynecology published a compelling statement that recognized the legalization of abortion in several states and anticipated the 1973 Supreme Court decision in Roe v Wade. They projected the numbers of legal abortions that likely would be required by women in the United States and described the role of the teaching hospital in meeting that responsibility. They wrote to express their concern for women's health in a new legal and medical era of reproductive control and to define the responsibilities of academic obstetrician-gynecologists. Forty years later, 100 professors examine the statement of their predecessors in light of medical advances and legal changes and suggest a further course of action for obstetrician gynecologists.

  18. An exploratory study of first year nursing students' learning in the clinical workplace.

    PubMed

    Grealish, Laurie; Ranse, Kristen

    2009-08-01

    This study explored how first year undergraduate nursing students learn in clinical placements as part of a program informed by Wenger's (1998) social theory of learning. Forty-nine written student narrative accounts of a learning experience were analysed and three triggers for learning were identified. The first trigger is that participation (or observation) of a task or procedure leads students into a complex, dramatic reading of nursing work. The second is that when students are personally (emotionally) confronted by the work, it presents a high challenge situation, recognized by students as a significant learning opportunity. The third trigger is encounters with different nurses assist students to construct an image of what they want to be as a nurse. These three triggers appear to align with Wenger's Communities of Practice constructs for identity, engagement, imagination, and alignment, and provides preliminary evidence supportive of the social theory of learning for nursing students on clinical placement.

  19. Five-Year Strategic Plan: Fiscal Years 2011-2015

    ERIC Educational Resources Information Center

    US Department of Education, 2010

    2010-01-01

    This paper presents the U.S. Department of Education (Department) Office of Inspector General (OIG) Strategic Plan for fiscal years 2011 through 2015. This plan describes the focus and direction of OIG's operations over the next five years, establishes its organizational goals, and outlines the strategies it will employ to reach those goals and…

  20. 7 CFR 932.19 - Crop year and fiscal year.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 7 Agriculture 8 2014-01-01 2014-01-01 false Crop year and fiscal year. 932.19 Section 932.19 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE OLIVES GROWN IN CALIFORNIA...

  1. 7 CFR 932.19 - Crop year and fiscal year.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 7 Agriculture 8 2012-01-01 2012-01-01 false Crop year and fiscal year. 932.19 Section 932.19 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE OLIVES GROWN IN CALIFORNIA...

  2. 7 CFR 932.19 - Crop year and fiscal year.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 7 Agriculture 8 2013-01-01 2013-01-01 false Crop year and fiscal year. 932.19 Section 932.19 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS AND ORDERS; FRUITS, VEGETABLES, NUTS), DEPARTMENT OF AGRICULTURE OLIVES GROWN IN CALIFORNIA...

  3. 7 CFR 932.19 - Crop year and fiscal year.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 7 Agriculture 8 2011-01-01 2011-01-01 false Crop year and fiscal year. 932.19 Section 932.19 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE OLIVES GROWN IN CALIFORNIA...

  4. 7 CFR 932.19 - Crop year and fiscal year.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Crop year and fiscal year. 932.19 Section 932.19 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE OLIVES GROWN IN CALIFORNIA...

  5. Changes in periodontal status of children and young adolescents: a one year longitudinal study.

    PubMed

    Peretz, B; Machtei, E E; Bimstein, E

    1993-01-01

    The purpose of the present study was to describe longitudinal changes in accumulation of dental plaque and gingival inflammation, and their effect on changes in sulcus depth of children and young adolescents. Forty one boys and 37 girls aged 1-12 years living in a rural community in Israel were included in the study. At baseline and 12 months later, Loe's Plaque Index (PlI) and Gingival Index (GI), and sulcus depth were examined. Boys' mean age was significantly lower than girls' mean age (6.04 + 2.76 years, and 7.68 + 2.84 years respectively). PlI, GI and sulcus depth were higher in the 12-month examination compared to baseline. PlI was slightly higher in boys, while GI was slightly higher in girls. These differences however, were not statistically significant. At baseline, sulcus depth was significantly greater in girls than in boys, while at 12 months the difference was not significant. The children were grouped by age as follows: 1-5 years, 6-9 years and 10-12 years. PlI and GI mean scores were significantly higher among the 6-9-year-old individuals. Mean sulcus depth for the 10-12-year-old children was greater than that of the 6-9-year-olds at baseline and after 12 months. The effect of age, PlI and GI on the outcome variable (sulcus depth) was examined using a correlation matrix. At baseline, age showed the highest correlation (r = 0.659) followed by GI (r = 0.364) and PlI (r = 0.123). The same pattern was also observed at the 12 months examination.(ABSTRACT TRUNCATED AT 250 WORDS)

  6. Review 08--A Year in

    ERIC Educational Resources Information Center

    Diverse: Issues in Higher Education, 2008

    2008-01-01

    Barack Obama's monumental presidential campaign took the nation by storm, a history-making and future-defining feat sure to keep academicians busy for many years to come. How America addresses race as a result of Obama's sweeping victory remains to be seen, but his election came in the same year New York state installed its first Black governor,…

  7. Project LIFT: Year 1 Report

    ERIC Educational Resources Information Center

    Norton, Michael; Piccinino, Kelly

    2014-01-01

    Research for Action (RFA) is currently in the second year of a five-year external evaluation of the Project Leadership and Investment for Transformation (LIFT) Initiative in the Charlotte-Mecklenburg School District (CMS). Project LIFT is a public-private partnership between CMS and the local philanthropic and business communities in Charlotte,…

  8. Emotional Development: 2 Year Olds

    MedlinePlus

    ... Español Text Size Email Print Share Emotional Development: 2 Year Olds Page Content Article Body It’s so ... to follow the ups and downs of a two-year-old. One moment he’s beaming and friendly; ...

  9. NETL: The First 100 Years

    ScienceCinema

    None

    2016-07-12

    The National Energy Technology Laboratory celebrates 100 years of innovative energy technology development. NETL has been a leader in energy technology development. This video takes a look back at the many accomplishments over the past 100 years. These advances benefit the American people, enhance our nation's energy security and protect our natural resources.

  10. Project LIFT: Year Two Report

    ERIC Educational Resources Information Center

    Norton, Michael; Piccinino, Kelly

    2014-01-01

    Research for Action (RFA) has completed its second year of a five-year external evaluation of the Project Leadership and Investment for Transformation (LIFT) Initiative in the Charlotte-Mecklenburg School District (CMS). Project LIFT is a public-private partnership between CMS and the local philanthropic and business communities in Charlotte,…

  11. Outlook: The Next Twenty Years

    SciTech Connect

    Murayama, Hitoshi

    2003-12-07

    I present an outlook for the next twenty years in particle physics. I start with the big questions in our field, broken down into four categories: horizontal, vertical, heaven, and hell. Then I discuss how we attack the bigquestions in each category during the next twenty years. I argue for a synergy between many different approaches taken in our field.

  12. NETL: The First 100 Years

    SciTech Connect

    2015-07-21

    The National Energy Technology Laboratory celebrates 100 years of innovative energy technology development. NETL has been a leader in energy technology development. This video takes a look back at the many accomplishments over the past 100 years. These advances benefit the American people, enhance our nation's energy security and protect our natural resources.

  13. The Year 2000 in Review

    ERIC Educational Resources Information Center

    McLendon, Lennox L.

    2002-01-01

    If the year 1999 was dominated by the intense efforts of the federal government to establish guidelines for compliance with the Workforce Investment Act (WIA) of 1998, the year 2000 was dominated by the field's efforts to implement plans to meet those guidelines. In addition to engaging in this time- and labor-intensive work, the field witnessed…

  14. Neurostimulation—Past, Present, and Beyond

    PubMed Central

    Ben-Menachem, Elinor

    2012-01-01

    Neurostimulation as a treatment for epilepsy has been around for almost 20 years in the form of vagus nerve stimulation. Newer types of neurostimulation are being developed and stand on the brink of approval for use. The two newest therapies, not yet approved in the United States, are deep brain stimulation and the Responsive Neurostimulator System . In fact, in Europe, approval has already been given for deep brain stimulation and newer forms of vagus nerve stimulation. Efficacy is similar between these therapies, and side effects are moderate, so what will be the future? The challenge will be to learn how to use these therapies correctly and offer the right treatment for the right patient. PMID:23118604

  15. Long-Term Results after Surgical Treatment of Ebstein's Anomaly: a 30-year Experience

    PubMed Central

    Kim, Min-Seok; Lim, Hong-Gook; Kim, Woong Han; Lee, Jeong Ryul

    2016-01-01

    Background and Objectives The aim of the study is to evaluate the long-term results after a surgical repair of Ebstein's anomaly. Subjects and Methods Forty-eight patients with Ebstein's anomaly who underwent open heart surgery between 1982 and 2013 were included. Median age at operation was 5.6 years (1 day-42.1 years). Forty-five patients (93.7%) demonstrated tricuspid valve (TV) regurgitation of less than moderate degree. When the patients were divided according to Carpentier's classification, types A, B, C, and D were 11, 21, 12, and 4 patients, respectively. Regarding the type of surgical treatment, bi-ventricular repair (n=38), one-and-a half ventricular repair (n=5), and single ventricle palliation (n=5) were performed. Of 38 patients who underwent a bi-ventricular repair, TV repairs were performed by Danielson's technique (n=20), Carpentier's technique (n=11), Cone repair (n=4), and TV annuloplasty (n=1). Two patients underwent TV replacement. Surgical treatment strategies were different according to Carpentier's types (p<0.001) and patient's age (p=0.022). Results There were 2 in-hospital mortalities (4.2%; 1 neonate and 1 infant) and 2 late mortalities during follow-up. Freedom from recurrent TV regurgitation rates at 5, 10, and 15 years were 88.6%, 66.3%, 52.7%, respectively. TV regurgitation recurrence did not differ according to surgical method (p=0.800). Survival rates at 5, 10, and 20 years were 95.8%, 95.8%, and 85.6%, respectively, and freedom from reoperation rates at 5, 10, and 15 years were 85.9%, 68.0%, and 55.8%, respectively. Conclusion Surgical treatment strategies were decided according to Carpentier's type and patient's age. Overall survival and freedom from reoperation rates at 10 years were 95.8% and 68.0%, respectively. Approximately 25% of patients required a second operation for TV during the follow-up. PMID:27721863

  16. Clinical and imaging predictors of 1-year and long-term mortality in light chain (AL) amyloidosis: a 5-year follow-up study.

    PubMed

    Migrino, Raymond Q; Harmann, Leanne; Christenson, Richard; Hari, Parameswaran

    2014-11-01

    Light chain amyloidosis (AL) involves multiorgan failure induced by amyloidogenic light chain proteins, and is associated with high mortality. We aimed to identify clinical, laboratory, and imaging parameters that would predict 1-year and long-term AL mortality. Forty-four biopsy-proven AL patients (61.5 ± 12 years, 20 females) underwent clinical evaluation including laboratory assays, echocardiography, and contrast cardiac magnetic resonance imaging (CMR, n = 31) prior to chemotherapy. Patients were prospectively followed for median duration of 62.7 months (interquartile range 35.5 months). Clinical and laboratory parameters were compared between 1-year survivors and nonsurvivors. Univariate Kaplan-Meier survival plots were calculated followed by stepwise logistic regression analysis to assess independent predictors of long-term survival. Eighteen (40.9 %) patients died within 1 year and an additional 10 subjects died during long-term follow-up. Patients who expired within 1 year presented with more advanced class of heart failure, higher alkaline phosphatase and uric acid, lower limb lead voltage on electrocardiography, shorter left ventricular ejection time (ET) on echocardiography, and a higher proportion of late gadolinium enhancement on CMR. On multivariable analysis, only ET ≤240 ms on echocardiography (hazard ratio (HR) 5.07, 95 % confidence interval (CI) 1.83-14.1, P = 0.002) and New York Heart Association functional class II-IV presentation (HR 1.0058, 95 % CI 1.0014-1.0103, P = 0.01) were independent predictors of AL mortality. In conclusion, AL amyloidosis is associated with high 1-year and long-term mortality. Among clinical, laboratory, and imaging parameters tested, an echocardiographic finding of ET ≤240 ms has independent and additive prognostic value to clinical heart failure evaluation in determining long-term survival of AL patients. This result may be important in the early identification of patients at risk.

  17. Changes in Exercise Capacity of Cardiac Asymptomatic Hereditary Hemochromatosis Subjects over 5-Year Follow up

    PubMed Central

    Shizukuda, Yukitaka; Smith, Kevin P.; Tripodi, Dorothy J.; Arena, Ross; Yau, Yu-Ying; Bolan, Charles D.; Waclawiw, Myron A.; Leitman, Susan F.; Rosing, Douglas R.

    2012-01-01

    Objective A long-term effect of hereditary hemochromatosis (HH) on aerobic exercise capacity (AEC) has not been well described. Design Forty-three HH and 21 volunteer control (VC) subjects who were asymptomatic underwent cardiopulmonary exercise testing using the Bruce protocol. AEC was assessed with minute ventilation (VE), oxygen uptake (VO2), and carbon dioxide production (VCO2) at baseline (BL) at a 5-year follow up (5Y) assessment. A paired t-test was used for analyses of normality data; otherwise, a Wilcoxon singed rank sum test was used. Results Thirty-three HH subjects and 18 VC subjects returned for a repeat CPX at 5Y (80% overall return rate). At 5Y, AEC was not different between the two groups. As compared with BL measurements, exercise time, peak VO2, and the VE/VCO2 slope did not differ statistically at 5Y between both groups. Iron depletion by phlebotomy for 5 years did not significantly affect AEC in newly diagnosed HH subjects at baseline (n=14) and cardiac arrhythmias during exercise tended to decrease after 5 years of therapy in this group. Conclusions The AEC of asymptomatic HH subjects treated with conventional therapy is not statistically affected by the disease over a 5-year period. PMID:22311055

  18. Social conformity persists at least one day in 6-year-old children.

    PubMed

    Sun, Sai; Yu, Rongjun

    2016-12-21

    Humans have a tendency to forgo their own attitudes or beliefs in order to better align with the interests of a majority, a behavioral process known as conformity. Social conformity has been widely studied among adults and adolescents, whereas experimental studies on the impact of peer influence among young children have been relatively limited. The current study aims to investigate both short-term and sustained conforming behaviors among children in situations of relatively low social pressure. Forty-one children aged 5 to 6 years rated the attractiveness of 90 faces presented serially followed by witnessing a group rating in the absence of peers. Subsequently, second judgement was made after 30 minutes (Experiment 1). Results show that 6-year-old children tended to conform to their peers when group ratings differed from their own ratings, while younger children did not. In Experiment 2, children were required to make the second judgment one day after exposure to group ratings. Similarly, children aged 6 years exhibited a sustained conformity effect even after one day. Our findings suggest that 6-year-old children spontaneously change their private opinions under implicit social influence from peers.

  19. Social conformity persists at least one day in 6-year-old children

    PubMed Central

    Sun, Sai; Yu, Rongjun

    2016-01-01

    Humans have a tendency to forgo their own attitudes or beliefs in order to better align with the interests of a majority, a behavioral process known as conformity. Social conformity has been widely studied among adults and adolescents, whereas experimental studies on the impact of peer influence among young children have been relatively limited. The current study aims to investigate both short-term and sustained conforming behaviors among children in situations of relatively low social pressure. Forty-one children aged 5 to 6 years rated the attractiveness of 90 faces presented serially followed by witnessing a group rating in the absence of peers. Subsequently, second judgement was made after 30 minutes (Experiment 1). Results show that 6-year-old children tended to conform to their peers when group ratings differed from their own ratings, while younger children did not. In Experiment 2, children were required to make the second judgment one day after exposure to group ratings. Similarly, children aged 6 years exhibited a sustained conformity effect even after one day. Our findings suggest that 6-year-old children spontaneously change their private opinions under implicit social influence from peers. PMID:28000745

  20. Visualizing Twenty Years of Applications

    SciTech Connect

    Potel, Mike; Wong, Pak C.

    2014-11-01

    This issue of IEEE Computer Graphics and Applications marks the 20th anniversary of the Applications department as a regular feature of the magazine. We thought it might be interesting to look back at the 20 years of Applications department articles to assess its evolution over that time. By aggregating all twenty years of articles and applying a little statistical and visual analytics, we’ve uncovered some interesting characteristics and trends we thought we’d share to mark this 20 year milestone.

  1. Reporting of Acute Flaccid Paralysis in Children under 15 years of age: Improving Surveillance, January 2009 - December 2014.

    PubMed

    Flanagan, P; O'Lorcain, P; Cotter, S; Connell, J; Lynch, B; Cunney, R; O'Flanagan, D

    2016-02-19

    Acute Flaccid Paralysis (AFP) surveillance, including case investigation and specimen collection is a gold standard method for poliomyelitis surveillance. The expected annual non-polio AFP rate <15 years of age in Ireland is = 1/100 000 population. This study reviewed all cases of AFP reported to the Irish Paediatric Surveillance Unit and the Health Protection Surveillance Centre between January 2009 and December 2014 and compared reporting rates with the expected incidence rate annually. We assessed quality of surveillance data in terms of completeness of investigation for each case reported. Forty-three AFP cases in children <15 years were notified; 35 of which were confirmed. Guillain-Barre Syndrome (GBS) accounted for 48.6% (n=17) of AFP notifications. In 2014, the expected annual AFP target rate was reached. This study identified possible under-reporting of AFP paediatric cases in Ireland between 2009-2013. Completeness of investigations has improved over time, but requires further work.

  2. First Quarter Hanford Seismic Report for Fiscal Year 2008

    SciTech Connect

    Rohay, Alan C.; Sweeney, Mark D.; Hartshorn, Donald C.; Clayton, Ray E.; Devary, Joseph L.

    2008-03-21

    The Hanford Seismic Assessment Program (HSAP) provides an uninterrupted collection of high-quality raw and processed seismic data from the Hanford Seismic Network for the U.S. Department of Energy and its contractors. The Hanford Seismic Assessment Team locates and identifies sources of seismic activity and monitors changes in the historical pattern of seismic activity at the Hanford Site. The data are compiled, archived, and published for use by the Hanford Site for waste management, natural phenomena hazards assessments, and engineering design and construction. In addition, the seismic monitoring organization works with the Hanford Site Emergency Services Organization to provide assistance in the event of a significant earthquake on the Hanford Site. The Hanford Seismic Network and the Eastern Washington Regional Network consist of 41 individual sensor sites and 15 radio relay sites maintained by the Hanford Seismic Assessment Team. For the Hanford Seismic Network, forty-four local earthquakes were recorded during the first quarter of fiscal year 2008. A total of thirty-one micro earthquakes were recorded within the Rattlesnake Mountain swarm area at depths in the 5-8 km range, most likely within the pre-basalt sediments. The largest event recorded by the network during the first quarter (November 25, 2007 - magnitude 1.5 Mc) was located within this swarm area at a depth of 4.3 km. With regard to the depth distribution, three earthquakes occurred at shallow depths (less than 4 km, most likely in the Columbia River basalts), thirty-six earthquakes at intermediate depths (between 4 and 9 km, most likely in the pre-basalt sediments), and five earthquakes were located at depths greater than 9 km, within the crystalline basement. Geographically, thirty-eight earthquakes occurred in swarm areas and six earth¬quakes were classified as random events.

  3. First Quarter Hanford Seismic Report for Fiscal Year 2001

    SciTech Connect

    Hartshorn, Donald C.; Reidel, Stephen P.; Rohay, Alan C.; Valenta, Michelle M.

    2001-02-27

    Hanford Seismic Monitoring provides an uninterrupted collection of high-quality raw and processed seismic data from the Hanford Seismic Network (HSN) for the U.S. Department of Energy and its contractors. Hanford Seismic Monitoring also locates and identifies sources of seismic activity and monitors changes in the historical pattern of seismic activity at the Hanford Site. The data are compiled, archived, and published for use by the Hanford Site for waste management, Natural Phenomena Hazards assessments, and engineering design and construction. In addition, the seismic monitoring organization works with the Hanford Site Emergency Services Organization to provide assistance in the event of a significant earthquake on the Hanford Site. The HSN and the Eastern Washington Regional Network (EWRN) consist of 41 individual sensor sites and 15 radio relay sites maintained by the Hanford Seismic Monitoring staff. For the HSN, there were 477 triggers during the first quarter of fiscal year (FY) 2001 on the data acquisition system. Of these triggers, 176 were earthquakes. Forty-five earthquakes were located in the HSN area; 1 earthquake occurred in the Columbia River Basalt Group, 43 were earthquakes in the pre-basalt sediments, and 1 was earthquakes in the crystalline basement. Geographically, 44 earthquakes occurred in swarm areas, 1 earthquake was on a major structure, and no earthquakes were classified as random occurrences. The Horse Heaven Hills earthquake swarm area recorded all but one event during the first quarter of FY 2001. The peak of the activity occurred over December 12th, 13th, and 14th when 35 events occurred. No earthquakes triggered the Hanford Strong Motion Accelerometers during the first quarter of FY 2001.

  4. 29 CFR 4010.5 - Information year.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... the basis of different fiscal years, the information year is the calendar year. (If any two members of... determination of whether an entity is an exempt entity is based on a calendar year information year for purposes... Company B has an October 1 fiscal year. The information year is the calendar year. Company A's...

  5. 29 CFR 4010.5 - Information year.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... the basis of different fiscal years, the information year is the calendar year. (If any two members of... determination of whether an entity is an exempt entity is based on a calendar year information year for purposes... Company B has an October 1 fiscal year. The information year is the calendar year. Company A's...

  6. Social Development:: 2 Year Olds

    MedlinePlus

    ... Español Text Size Email Print Share Social Development: 2 Year Olds Page Content Article Body By nature, ... probably are acting the same way. At age two, children view the world almost exclusively through their ...

  7. The First Year and Beyond.

    ERIC Educational Resources Information Center

    Schroeder, Charles

    2003-01-01

    John Gardner reflects on everything from current efforts to improve the first-year experience to the assessment movement, student expectations of college, professional preparation for student affairs, and more. (Author)

  8. Communications satellites - The experimental years

    NASA Technical Reports Server (NTRS)

    Edelson, B. I.

    1983-01-01

    Only eight years after the launc of Sputnik-1 by the Soviet Union, the first commercial satellite, 'Early Bird', entered service. In just twelve years commercial satellite service extended around the earth and became profitable. The reasons for the successful development of the communications satellite services in a comparatively short time are considered. These reasons are related to the presence of three ingredients, taking into account technology to create the system, communications requirements to form a market, and a management structure to implement the system. The formation of the concept of using earth orbiting satellites for telecommunications is discussed. It is pointed out that the years from 1958 to 1964 were the true 'experimental years' for satellite communications. The rapid development of technology during this crucial period is described, giving attention to passive satellites, active systems, and development satellites.

  9. 1993: Year of the Perseids

    NASA Astrophysics Data System (ADS)

    Brown, P.; Rendtel, J.

    1994-01-01

    A summary of the observational results of the Aug. 1993 Perseid meteor shower along with photographs of the event are presented. Topics covered include the following: Perseid peaks, fireballs, zenithal hourly rate, and predictions for next year.

  10. Crafts in the Middle Years

    ERIC Educational Resources Information Center

    Porter, D. I. R.

    1972-01-01

    In the middle years of schooling, size, measurement, shape and form build up a child's mathematical and visual concepts. A restless drive to create, to see what happens in making something, can provide the driving force in crafts. (Editor)

  11. Three Years of SDO Data

    NASA Video Gallery

    In the three years since it first provided images of the sun in thespring of 2010, NASA’s Solar Dynamics Observatory (SDO) has had virtuallyunbroken coverage of the sun's rise toward solar maxi...

  12. Annual Plan - Fiscal Year 2012

    EPA Pesticide Factsheets

    This plan identifies mandated and selected assignment topics continuing from fiscal year (FY) 2011 and scheduled to be started during FY 2012, providing for unforeseen work that may be requested by hotline complaints, EPA leadership, and Congress.

  13. Accountability report - fiscal year 1997

    SciTech Connect

    1998-04-01

    This document contains the US NRC`s accountability report for fiscal year 1997. Topics include uses of funds, financial condition, program performance, management accountability, and the audited financial statement.

  14. Katrina Retrospective: 5 Years Later

    NASA Video Gallery

    Five years after Hurricane Katrina struck the Gulf Coast, NASA revisits the storm with a short video that shows Katrina as captured by satellites. Before and during the hurricane's landfall, NASA p...

  15. 25 Years of Landsat 5

    NASA Video Gallery

    Twenty-two years beyond its primary mission lifetime, Landsat 5 is still going strong. It has charted urban growth in Las Vegas, monitored fire scars in Yellowstone National Park, and tracked the r...

  16. Celebrating 20 Years of Hubble

    NASA Video Gallery

    NASA's Hubble Space Telescope began a remarkable journey of discovery on April 24, 1990. After 20 years in space, the observatory has shown humanity more of the universe than ever before. With the ...

  17. Ecological Monitoring and Compliance Program Fiscal Year 2000 Report

    SciTech Connect

    Wills, C.A.

    2000-12-01

    The Ecological Monitoring and Compliance program, funded through the U.S. Department of Energy, Nevada Operations Office, monitors the ecosystem of he Nevada Test Site (NTS) and ensures compliance with laws and regulations pertaining to NTS biota. This report summarizes the program's activities conducted by Bechtel Nevada during fiscal year 2000. Program activities included: (1) biological surveys at proposed construction sites, (2) desert tortoise compliance,(3) ecosystem mapping, (4) sensitive species and unique habitat monitoring, and (5) biological monitoring at the HAZMAT Spill Center. Biological surveys for the presence of sensitive species were conducted for 24 NTS projects. Seventeen sites were in desert tortoise habitat, and six acres of tortoise habitat were documented as being disturbed this year. No tortoises were found in or displaced from project areas, and no tortoises were accidentally injured or killed. A topical report describing the classification of habitat types o n the NTS was completed. The report is the culmination of three years of field vegetation mapping and the analysis of vegetation data from over 1,500 ecological landform units. A long-term monitoring plan for important plant species that occur on the NTS was completed. Sitewide inventories were conducted for the western burrowing owl, bat species of concern, wild horses, raptor nests, and mule deer. Fifty-nine of 69 known owl burrows were monitored. Forty-four of the known burrows are in disturbed habitat. As in previous years, some owls were present year round on the NTS. An overall decrease in active owl burrows was observed within all three ecoregions (Mojave Desert, Transition, Great Basin Desert) from October through January. An increase in active owl burrows was observed from mid-March to early April. A total of 45 juvenile owls was detected from eight breeding pairs. One nest burrow was detected in the Mojave Desert,one in the Great Basin Desert, and six in the Transition

  18. Adaptive and Maladaptive Correlates of Repetitive Behavior and Restricted Interests in Persons with Down Syndrome and Developmentally-Matched Typical Children: A Two-Year Longitudinal Sequential Design

    PubMed Central

    Evans, David W.; Kleinpeter, F. Lee; Slane, Mylissa M.; Boomer, K. B.

    2014-01-01

    We examined the course of repetitive behavior and restricted interests (RBRI) in children with and without Down syndrome (DS) over a two-year time period. Forty-two typically-developing children and 43 persons with DS represented two mental age (MA) levels: “younger” 2–4 years; “older” 5–11 years. For typically developing younger children some aspects of RBRI increased from Time 1 to Time 2. In older children, these aspects remained stable or decreased over the two-year period. For participants with DS, RBRI remained stable or increased over time. Time 1 RBRI predicted Time 2 adaptive behavior (measured by the Vineland Scales) in typically developing children, whereas for participants with DS, Time 1 RBRI predicted poor adaptive outcome (Child Behavior Checklist) at Time 2. The results add to the body of literature examining the adaptive and maladaptive nature of repetitive behavior. PMID:24710387

  19. Four Mars Years of Change

    NASA Technical Reports Server (NTRS)

    2005-01-01

    23 May 2005 These two Mars Global Surveyor (MGS) Mars Orbiter Camera (MOC) images were acquired a little more than four Mars years apart. One Mars year is about 687 Earth days long. The two images show a portion of the south polar cap, which is composed of frozen, layered, carbon dioxide. Each Mars year since MGS has been observing the planet, the mesas and buttes composed of carbon dioxide have gotten a little bit smaller, and the pits and holes have become a little bit wider. The scarps formed in frozen carbon dioxide in the south polar region are retreating at an average rate of about 3 meters per Mars year. The example shown here includes an image obtained in August 1999, and a more recent picture from April 2005. Arrow '1' points to a dramatic example of the changes that have occurred; in this case a mesa shrank to a small butte in just four martian years. Arrow '2' indicates pits that developed in the cap layer of a carbon dioxide mesa that eroded during the same interval. Acquired during early southern spring, both images are illuminated by sunlight from the upper left.

  20. Why Is the Year 2000 a Leap Year?

    ERIC Educational Resources Information Center

    Wilkins, Jesse L. M.

    2000-01-01

    The study of leap year and its development offers an interesting real-world situation for students to exercise qualitative reasoning about operations on decimals. Presents an activity in which students investigate time measurement by studying a variety of calendars, past and present. (ASK)

  1. LNG to the year 2000

    SciTech Connect

    Davenport, S.T.

    1984-04-01

    By 2000, about 190 MM metric-tpy of LNG will be moving in world trade, with Asia-Pacific as the dominant producer By the year 2000, approximately 190 million metric tons per year of LNG will be moving in worldwide trade. Production of LNG will be spread throughout most of the world, with Asia-Pacific as the dominant producer. LNG will be delivered only to the heavily industrialized areas of North America, Europe and Asia-Pacific. The success of any LNG project will be dependent on its individual economics, market needs, financial planning, and governmental permit processes. We hope industry will be able to put together the LNG projects required to meet the quanitities of production forecast here for the year 2000.

  2. The Synucleinopathies: Twenty Years On

    PubMed Central

    Goedert, Michel; Jakes, Ross; Spillantini, Maria Grazia

    2017-01-01

    In 2017, it is two hundred years since James Parkinson provided the first complete clinical description of the disease named after him, fifty years since the introduction of high-dose D,L-DOPA treatment and twenty years since α-synuclein aggregation came to the fore. In 1998, multiple system atrophy joined Parkinson’s disease and dementia with Lewy bodies as the third major synucleinopathy. Here we review our work, which led to the identification of α-synuclein in Lewy bodies, Lewy neurites and Papp-Lantos bodies, as well as what has happened since. Some of the experiments described were carried out in collaboration with ML Schmidt, VMY Lee and JQ Trojanowski. PMID:28282814

  3. [Senior years, subjectivation, and biopolitics].

    PubMed

    Birman, Joel

    2015-12-01

    The article explores the historical emergence of "senior years" as a contemporary signifier and concept that has left behind the previous interpretation of the aging process in modernity. It addresses this vital shift that occurred in the history of the West from an interdisciplinary perspective that encompasses social, economic, political, and familial interpretations. Emphasizing forms of subjectivation found during the senior years, it offers a critical interpretation of theoretical writings in psychopathology and neurology and highlights the process of social exclusion suffered by the elderly in the historical context of modernity.

  4. Ten Thousand Years of Solitude

    SciTech Connect

    Benford, G. California Univ., Irvine, CA . Dept. of Physics); Kirkwood, C.W. Arizona State Univ., Tempe, AZ . Coll. of Business Administration); Harry, O. ); Pasqualetti, M.J. Arizona State Univ., Tempe, AZ )

    1991-03-01

    This report documents the authors work as an expert team advising the US Department of Energy on modes of inadvertent intrusion over the next 10,000 years into the Waste Isolation Pilot Project (WIPP) nuclear waste repository. Credible types of potential future accidental intrusion into the WIPP are estimated as a basis for creating warning markers to prevent inadvertent intrusion. A six-step process is used to structure possible scenarios for such intrusion, and it is concluded that the probability of inadvertent intrusion into the WIPP repository over the next ten thousand years lies between one and twenty-five percent. 3 figs., 5 tabs.

  5. 35 years of DEB research

    NASA Astrophysics Data System (ADS)

    van der Meer, Jaap; Klok, Chris; Kearney, Michael R.; Wijsman, Jeroen W. M.; Kooijman, Sebastiaan A. L. M.

    2014-11-01

    Research on the Dynamic Energy Budget (DEB) theory started 35 years ago. Initially much emphasis was put on the development of a consistent theory. During recent years attention was paid on parameterizing DEB models for a huge collection of species. This enables the search for patterns in parameter values in an ecological and evolutionary context. This special issue presents some of the results of this quest, among other things focusing on the development of metabolic acceleration, combined with various applications of DEB theory in fisheries, aquaculture, climate science and ecotoxicology.

  6. HAWC 1st year catalog

    NASA Astrophysics Data System (ADS)

    Riviére, Colas; HAWC Collaboration

    2017-01-01

    The High Altitude Water Cherenkov (HAWC) Observatory was inaugurated in March 2015. With its high duty cycle and wide field of view, it observes 2/3 of the TeV sky daily. After a single year of observation, the integral sensitivity already exceeds that of the previous generation of wide field instruments by a factor of five. We will present the results of the first all sky search with a year of data of the complete HAWC detector. Some known sources as well as new TeV point and extended sources will be highlighted.

  7. The Athens stroke registry: results of a five-year hospital-based study.

    PubMed

    Vemmos, K N; Takis, C E; Georgilis, K; Zakopoulos, N A; Lekakis, J P; Papamichael, C M; Zis, V P; Stamatelopoulos, S

    2000-01-01

    The advent and wide application of new technology, especially noninvasive techniques, has enabled physicians to more completely investigate and clarify the etiopathogenic mechanisms of stroke. Such data have not been available until recently for Southeastern Europe. In addition, during the last decades, strategies for the modification of risk factors and primary prevention may have changed the prevalence of each subgroup of stroke as well. We investigated 1, 042 consecutive patients who had first strokes, during a period of 5 years (from June 1992 to May 1997) and classified them prospectively based on etiopathogenic mechanisms. Patients with transient ischemic attacks and subarachnoid hemorrhage were excluded. There were 613 male and 429 female patients, with a mean age of 70.2 +/- 11.9 years. Forty-six percent of the patients arrived within 3 h from stroke onset. The probable mechanisms were: large-artery atherosclerosis, 156 (15%); lacunes, 177 (17%); cardioembolic, 335 (32.1%); infarct of unknown cause, 182 (17.5%); miscellaneous causes, 35 (3.3%), and intracerebral hemorrhage (ICH), 157 (15.1%). In the cardioembolic group, nonvalvular atrial fibrillation (NVAF) was the probable cause in 225 patients, especially in patients older than 75 years (65%). The overall hospital mortality was 15.2% (from 0.6% for lacunar stroke to 34% for ICH). In our population, cardioembolism is the most frequent subtype of stroke. NVAF is the most likely source, especially in older patients.

  8. Psychological adaptation to pregnancy in childless women more than 35 years of age.

    PubMed

    Robinson, G E; Garner, D M; Gare, D J; Crawford, B

    1987-02-01

    Forty-five pregnant childless women with a mean age of 36.6 years (+/- 1.7) were compared with 42 nulliparous pregnant women with a mean age of 26.7 years (+/- 2.8). Initial interviews determined the basic demographic data, the reasons for delaying pregnancy, attitudes to pregnancy, and plans concerning careers. Psychological tests were given to measure anxiety, depression, anger, marital intimacy, sense of autonomy, and role expectations. These psychological tests were applied to all patients at 12 to 16 weeks' gestation and again at 28 to 32 weeks' gestation. The demographic information from the two groups was remarkably similar. Although their ages differed by 10 years, their career goals, their family incomes, reasons for delaying pregnancy, and reasons for now getting pregnant revealed minimal differences. The Maffer Feminine Identity Scale revealed that the younger women held more traditional attitudes toward a woman's roles than the older group. The Sociotrophy-Autonomy Scale indicated that the older women were more independent than the younger pregnant patients. The Symptom Checklist indicated that the older group were less troubled by pregnancy than the control group, and although their level of distress increased as the pregnancy progressed, they remained better adjusted as they entered the last trimester of their pregnancies.

  9. Research in child psychoanalysis: twenty-five-year follow-up of a severely disturbed child.

    PubMed

    Tyson, Phyllis

    2009-08-01

    In an era of managed care, psychoanalytic treatment of children is under fire as critics question whether the evidence of success in child analysis is sufficiently robust to warrant the large commitment of time and money required for this treatment. This article chronicles the history and current state of research at the Anna Freud Centre, and describes the evolution of a database that has methodically recorded and systematically organized data from over 750 cases of children referred to the Centre over a forty-five-year period. Analysis of this database has determined what kinds of childhood disorders are best treated with intensive psychoanalysis, and what kinds do not respond to this form of treatment. A long-term follow-up of a small sample of these childreen suggests the kinds of long-term benefits that can be gained when an individual is treated with intensive psychoanalysis as a child. As an example, clinical material from the analysis of an eight-year-old is presented along with follow-up interview data twenty-five years later.

  10. A 3-year randomized clinical trial evaluating two different bonded posterior restorations: Amalgam versus resin composite

    PubMed Central

    Kemaloglu, Hande; Pamir, Tijen; Tezel, Huseyin

    2016-01-01

    Objective: To compare the performance and postoperative sensitivity of a posterior resin composite with that of bonded amalgam in 40 (n = 20) large sized cavities and to evaluate whether resin composite could be an alternative for bonded amalgam. Materials and Methods: This was a randomized clinical trial. Twenty patients in need of at least two posterior restorations were recruited. Authors randomly assigned one half of the restorations to receive bonded amalgam and the other half to composite restorations. Forty bonded amalgams (n = 20) and composites (n = 20) were evaluated for their performance on modified-US Public Health Service criteria and postoperative sensitivity using visual analogue scale (VAS) for 36-months. Results: Success rate of this study was 100%. First clinical alterations were rated as Bravo after 1 year in marginal discoloration, marginal adaptation, anatomical form, and surface roughness for both amalgam and composite. At the 3rd year, overall “Bravo” rated restorations were 12 for bonded amalgam and 13 for resin composites. There were no significant differences among the VAS scores of composites and bonded amalgams for all periods (P > 0.05) except for the comparisons at the 3rd year evaluation (P < 0.05). Conclusions: Within the limitation of this study, both resin composite and bonded amalgam were clinically acceptable. Postoperative sensitivity results tend to decrease more in composite restorations rather than amalgams. Therefore, it was concluded that posterior resin composite can be used even in large sized cavities. PMID:27011734

  11. Surgical treatment of aneurysms of the ascending aorta. Twelve years' experience in 66 patients.

    PubMed

    Markewitz, A; Weinhold, C; Kemkes, B M; Reichart, B; Hemmer, W; Klinner, W

    1986-10-01

    This study presents the results in 66 patients undergoing surgery for concomitant supracoronary vascular interposition and valve replacement carried out at the Department of Cardiac Surgery of the University of Munich, West-Germany, over a period of 12 years (from July 1, 1973 to June 30, 1985) using a technique similar to that described by Wheat. Forty-seven percent of the cases were true aneurysms and 20% chronic dissections. Thirty-three percent of patients had acute dissections. Early mortality was 16% in the total patient population, 9% in the group having true aneurysm and 32% in the group having acute dissection. No early death was observed in association with chronic dissections. The actuarial one-year survival rate in patients with true aneurysm or chronic dissection was 83.6%, and 54.1% in patients with acute dissection. The corresponding 4-year survival rates were 76.4% and 54.1%, respectively. The average improvement according to the New York Heart Association classification was 1.5 grades. These results confirm that the operative approach to ascending aortic aneurysms is superior to medical treatment, with the operative method involving vascular graft without concomitant aortic valve replacement as well as the method described by Wheat having both proved successful.

  12. Stress among First and Third Year Medical Students at University Kebangsaan Malaysia

    PubMed Central

    Salam, Abdus; Mahadevan, Raynuha; Abdul Rahman, Amir; Abdullah, Norsyafiqah; Abd Harith, Aimi Aqilah; Shan, Chu Pei

    2015-01-01

    Objective: To identify the stress-prevalence and coping-strategies among University Kebangsaan Malaysia (UKM) medical students. Methods: This was an observational study conducted among 234 UKM first and third year medical students. Standardized questionnaire on stress and coping strategies was used. Stress data was related to subjective experiences on some positive and negative adjectives such as tense, relaxed etc. Positive adjectives were measured by sign “++” and “+” scoring “1” while stress-negative adjectives were measured by sign “?” and “–“ scoring “0”. Forty-eight coping items under task, emotion and avoidance strategies were measured using 5-point Likert-scale. Results: Overall stress-prevalence was 49%. Female and Malay respondents were more stressed. Significant differences of stress-level was observed between Malays and non Malays in first year (p=0.04) and in third year (p=0.01). Most common strategies used to cope stress was task-oriented while emotion oriented was least. Conclusion: Stress-prevalence and stress-level in UKM medical students was high. Most of the respondents coped stress using task-oriented strategies. Stressor and its effective management must be ensured. Educational institutions should act as a creative designer of learning environment to get relieve from educational stressor. PMID:25878637

  13. Injury profile in junior tennis players: a prospective two year study.

    PubMed

    Hjelm, Nina; Werner, Suzanne; Renstrom, Per

    2010-06-01

    The aim of this study was to prospectively make a survey of injuries in junior players from a Swedish local tennis club during a 2-year period in relation to gender, anatomic location, month of the year when injured, injury type and injury severity. All 12-18 years old members in a tennis club playing more than twice weekly were asked to participate. Fifty-five junior tennis players, 35 boys and 20 girls accepted to participate. All tennis-related injuries were prospectively registered and evaluated. Time of exposure for playing tennis was recorded. Thirty-nine players sustained 100 injuries, 73 in boys and 27 in girls. Injury incidence for boys was 1.7 injuries/1000 h of tennis playing time and for girls 0.6 injuries/1000 h. Ankle sprains, low back pain and knee injuries were the most common ones. Sixty-five percent were new injuries, and the majority of these injuries were located at the knee joint followed by the ankle joint, while most of the recurrent injuries were found in the lumbar spine. Boys suffered mainly from low back pain and ankle injuries and girls from low back pain and knee injuries. Forty-three percent of the injuries caused absence from tennis for more than 4 weeks and 31% more than 1 week.

  14. A Ten-Year Reflection

    ERIC Educational Resources Information Center

    Phillip, Cyndi

    2016-01-01

    Five initiatives launched during Cyndi Phillip's term as American Association of School Librarians (AASL) President (2006-2007) continue to have an impact on school librarians ten years later. They include the rewriting of AASL's learning standards, introduction of the SKILLS Act, the presentation of the Crystal Apple Award to Scholastic Library…

  15. 70 Years and Going Strong

    ERIC Educational Resources Information Center

    Jones, Alan H.

    2015-01-01

    The survival and prosperity of the California Council on the Education of Teachers/California Council on Teacher Education (CCET/CCTE) over its 70 years of existence is remarkable, especially given the historic roller coaster of educational policy and practice in the United States--the ups and downs of school financing, in addition to the ins and…

  16. 2004: A Year in Review

    ERIC Educational Resources Information Center

    Commodore, Felecia; Anyaso, Hilary Hurd

    2004-01-01

    The 50th anniversary of Brown v. Board of Education and, of course, the hotly contested U.S. presidential election were just two of the events that dominated the headlines in 2004. Throughout the year, colleges and universities, as well as other educational institutions across the country, commemorated the Supreme Court's landmark case by…

  17. Budget Response: Fiscal Year 2012

    ERIC Educational Resources Information Center

    Bissonnette, Jocelyn, Ed.; Ellerson, Noelle, Ed.; Jones, Lindsay, Ed.

    2011-01-01

    The Committee for Education Funding (CEF), a coalition of over 85 national education associations and institutions from preschool to postgraduate education, applauds President Obama's Fiscal Year 2012 budget for recognizing the importance of investing in education to our nation's economic growth and competitiveness. Within a constrained fiscal…

  18. Language Development: 1 Year Olds

    MedlinePlus

    ... Stages Listen Español Text Size Email Print Share Language Development: 1 Year Olds Page Content Article Body ... assured, it’s not your imagination. He’s developing his language and comprehension skills right on schedule. This giant ...

  19. "Lake Woebegone," Twenty Years Later

    ERIC Educational Resources Information Center

    Cannell, John Jacob

    2006-01-01

    Almost 20 years ago, the author wrote--and then privately published--the two "Lake Woebegone" reports, named after Garrison Keillor's mythical Minnesota town where "all the women are strong, all the men are good-looking, and all the children are above average." The first "Lake Woebegone" report documented that all 50 states were testing above the…

  20. Yearbook 1988. IWGIA: 20 Years.

    ERIC Educational Resources Information Center

    Gray, Andrew

    The theme of this yearbook is the work of the International Work Group for Indigenous Affairs (IWGIA) during the 20 years of its existence and the enormous growth of the indigenous movement in that time. Section 1 traces IWGIA's history and includes the annual report for 1988. Section 2 is a global view of the main events in the indigenous world…

  1. Teen Parenting: The First Year.

    ERIC Educational Resources Information Center

    McCamey, Jody

    This guide for teenage mothers discusses the needs of the mother and her child during the first year of the child's life. Information on the child's and the mother's behavior and emotions just after the child's birth is presented. Also presented is information on the following: procuring items needed for tending the baby; playing; crying; breast…

  2. 1974 is World Population Year.

    ERIC Educational Resources Information Center

    Asian Population Programme News, 1974

    1974-01-01

    This publication is a special issue of the Asian Population Programme News. This particular publication is concerned with population year 1974. Highlights from the thirtieth session of the Economic Commission for Asia and the Far East (ECAFE) are presented. World, regional, and country population news are included in separate sections. A listing…

  3. My Year of Living Dangerously.

    ERIC Educational Resources Information Center

    Sahar, Emily

    1991-01-01

    A White reporter describes how she changed careers to teach poor Black and Hispanic New York City public intermediate students, focusing on her top math class. After one difficult year, she left teaching but hopes to return some day because she felt she made a difference for a few students. (SM)

  4. CEC Teacher of the Year.

    ERIC Educational Resources Information Center

    Voyles, Lynda

    1995-01-01

    This interview with Brenda Jean Robbins, a Florida music therapist and teacher selected as 1995 Teacher of the Year by the Council for Exceptional Children, reveals her views about music therapy, goals, relationship of music therapy to the special education classroom, musical performance, and getting parents involved. (DB)

  5. European Year of Languages, 2001.

    ERIC Educational Resources Information Center

    Council of Europe, Strasbourg (France). Directorate of Education, Culture and Sport, Documentation Section.

    This document is a folder full of brochures describing the activities of Council of Europe and the European Union to celebrate 2001 as a year of languages in order to celebrate the linguistic diversity of Europe and promote the many opportunities available for lifelong language learning. A number of facts and figures about the languages of Europe…

  6. Humanities Computing 25 Years Later.

    ERIC Educational Resources Information Center

    Raben, Joseph

    1991-01-01

    Provides an overview of the development of humanities computing during the past 25 years. Mentions the major applications of the computer to humanities disciplines including the generation of concordances, attempts at dating works of major authors, proving authorship, defining style, and compiling indexes. Discusses lexicographical uses and…

  7. Annual Report, Fiscal Year 1983.

    ERIC Educational Resources Information Center

    Department of Education, Washington, DC.

    As mandated by Congress, this annual report from the U.S. Department of Education (ED) describes its activities in the past fiscal year (FY). Secretary of Education, T. H. Bell, summarizes ED accomplishments in FY 1983 in such areas as excellence in education, citing the findings and impact of the report "A Nation at Risk"; the…

  8. International Education Year 1970. Bulletin.

    ERIC Educational Resources Information Center

    United Nations Educational, Scientific, and Cultural Organization, Paris (France).

    Bulletin number 1 of 17 stated that it will be published at regular monthly intervals. Its purpose is to inform member states, United Nations agencies, National Commissions for UNESCO, non-governmental and inter-governmental organizations of plans for "International Education Year 1970 (IEY)" and coming events. As proclaimed by…

  9. FEMP Year in Review 2009

    SciTech Connect

    2009-12-01

    In 2009, the Federal Energy Management Program (FEMP)undertook an ambitious reorganization of its program structure to be more responsive to the needs of its Federal agency customers. In this Year in Review 2009, you will learn more about FEMP achievements under its new program areas.

  10. The Year-Round School.

    ERIC Educational Resources Information Center

    Torge, Herman

    This study consists of a review of the literature, a discussion of some of the vital questions concerning the year-round school, and a bibliography. Discussed are (1) quarter schedules of various types and their applications to school calendars, (2) transitions to quarter schedules from conventional schedules, (3) teacher and staff assignments,…

  11. 2007: A Year In Review

    ERIC Educational Resources Information Center

    Diverse: Issues in Higher Education, 2007

    2007-01-01

    The most high-profile story of the year touching the higher education community was undisputedly the killings at Virginia Tech in April when student Seung-Hui Cho opened fire, leaving 33 people dead, including himself. To date, it is the deadliest campus shooting in U.S. history. However, in September, the Delaware State University (DSU) community…

  12. Celebrating 75 years of research

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The USDA Ag Lab in Peoria helps bridge the gap between agricultural producers and commercial manufacturers. In 2015, the Ag Lab, officially known as the Agricultural Research Service (ARS) National Center for Agricultural Utilization Research (NCAUR), is celebrating 75 years of research in Peoria. T...

  13. The Year of the Pond

    ERIC Educational Resources Information Center

    Hinshaw, Craig

    2010-01-01

    Water gardens became popular in China during the Tang Dynasty and goldfish were domesticated more than 1000 years ago. Beyond being beautiful and tranquil, water gardens have the potential for much learning in an educational setting, especially for learning through art. In this article, the author shares how he collaborated with another teacher in…

  14. 100 Years of ACCU Leadership.

    ERIC Educational Resources Information Center

    Simmons, Andrew N.

    1999-01-01

    Chronicles the administrative organization and governance of the Association of Catholic Colleges and Universities over its 100-year history, especially the membership and role of the executive committee and major organizational changes. A chart and timeline lists leaders since 1899. (MSE)

  15. The Year of Secret Assignments

    ERIC Educational Resources Information Center

    Moriarty, Jaclyn

    2004-01-01

    The path to "novelist" was a convoluted one for Moriarty, who began writing fiction as doctoral student at Cambridge University. Her interest in young adults stems from an appreciation for the "troubles, strengths, and surprises of that age group." Now, in a uniquely formatted book titled "The Year of Secret Assignments," we peek inside the mind…

  16. Nuclear Materials Focus Area Fiscal Year 2002 Mid Year Review

    SciTech Connect

    Thiel, E.C.; Fuhrman, P.W.

    2002-05-30

    The Nuclear Materials Focus Area (NMFA) held its annual mid-year review on February 12 and 14, 2002, in Santa Fe, New Mexico. The purpose of this review was to examine both the technical aspects and the programmatic aspects of its technology development program. The focus area activities were reviewed by a panel consisting of personnel representing the end users of the technologies, and technical experts in nuclear materials. This year's review was somewhat different than in the past, as the stress was on how well the various projects being managed through the NMFA aligned with the two thrust areas and nine key goals and priorities recently issued by the Deputy Assistant Secretary for DOE's Office of Environmental Management (EM).

  17. Nuclear Materials Focus Area Fiscal Year 2002 Mid Year Review

    SciTech Connect

    Thiel, Elizabeth Chilcote

    2002-05-01

    The Nuclear Materials Focus Area (NMFA) held its annual mid-year review on February 12 and 14, 2002, in Santa Fe, New Mexico. The purpose of this review was to examine both the technical aspects and the programmatic aspects of its technology development program. The focus area activities were reviewed by a panel consisting of personnel representing the end users of the technologies, and technical experts in nuclear materials. This year's review was somewhat different than in the past, as the stress was on how well the various projects being managed through the NMFA aligned with the two thrust areas and nine key goals and priorities recently issued by the Deputy Assistant Secretary for DOE's Office of Environmental Management (EM).

  18. High-Dose-Rate Rotte 'Y' Applicator Brachytherapy for Definitive Treatment of Medically Inoperable Endometrial Cancer: 10-Year Results

    SciTech Connect

    Coon, Devin; Beriwal, Sushil Heron, Dwight E.; Kelley, Joseph L.; Edwards, Robert P.; Sukumvanich, Paniti; Zorn, Kristin K.; Krivak, Thomas C.

    2008-07-01

    Purpose: To assess the intermediate clinical outcomes of medically inoperable patients with endometrial cancer treated with definitive Rotte 'Y' applicator high-dose-rate brachytherapy (HDRB) over a 10-year period. Methods and Materials: Forty-nine inoperable patients were treated with HDRB from 1997 to 2007. Forty three (84%) were markedly obese (body mass index >35 kg/m{sup 2}). Thirty-one patients (63.3%) underwent two-dimensional treatment planning, whereas 18 patients (36.7%) underwent three-dimensional treatment planning. Thirty five of the patients (71.4%) were first treated with external beam radiotherapy (EBRT). For patients receiving EBRT in addition to HDRB, the median Y-applicator dose was 20 Gy in 5 fractions; for patients receiving HDRB alone it was 35 Gy in 5 fractions. All patients received two Y-applicator treatments per day. Results: Median follow-up time for all patients was 33 months. Acute HDRB toxicities were limited to Grade 1 and 2 occurring in 5 patients. One patient had a myocardial infarction. Four patients had late Grade 2 or 3 toxicity. Three patients had local recurrence (median time to recurrence, 16 months). The 3- and 5-year actuarial cause-specific survival rates were 93% and 87%, respectively; the overall survival rate was 83% and 42%, respectively, at 3 and 5 years. Conclusions: Twice-daily HDRB using a Y-applicator is a well-tolerated and efficacious regimen for the definitive treatment of medically inoperable patients with early-stage endometrial cancer. The recent incorporation of three-dimensional treatment planning has the potential to further decrease treatment morbidities.

  19. Modelfest: year one results and plans for future years

    NASA Astrophysics Data System (ADS)

    Carney, Thom; Tyler, Christopher W.; Watson, Andrew B.; Makous, Walter; Beutter, Brent; Chen, Chien-Chung; Norcia, Anthony M.; Klein, Stanley A.

    2000-06-01

    A robust model of the human visual system (HVS) would have a major practical impact on the difficult technological problems of transmitting and storing digital images. Although most HVS models exhibit similarities, they may have significant differences in predicting performance. Different HVS models are rarely compared using the same set of psychophysical measurements, so their relative efficacy is unclear. The Modelfest organization was formed to solve this problem and accelerate the development of robust new models of human vision. Members of Modelfest have gathered psychophysical threshold data on the year one stimuli described at last year's SPIE meeting. Modelfest is an exciting new approach to modeling involving the sharing of resources, learning from each other's modeling successes and providing a method to cross-validate proposed HVS models. The purpose of this presentation is to invite the Electronic Imaging community to participate in this effort and inform them of the developing database, which is available to all researchers interested in modeling human vision. In future years, the database will be extended to other domains such as visual masking, and temporal processing. This Modelfest progress report summarizes the stimulus definitions and data collection methods used, but focuses on the results of the phase one data collection effort. Each of the authors has provided at least one dataset from their respective laboratories. These data and data collected subsequent to the submission of this paper are posted on the WWW for further analysis and future modeling efforts.

  20. 5 CFR 1690.11 - Plan year.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... Plan year. The Thrift Savings Plan's plan year is established on a calendar-year basis for all purposes... used in this section, the term “calendar-year basis” means a twelve-month period beginning on January...