Searching for Beta-Haemolysin hlb Gene in Staphylococcus pseudintermedius with Species-Specific Primers.

PubMed

Kmieciak, Wioletta; Szewczyk, Eligia M; Ciszewski, Marcin

2016-07-01

The paper presents an analysis of 51 Staphylococcus pseudintermedius clinically isolated strains from humans and from animals. Staphylococcus pseudintermedius strains' ability to produce β-haemolysin was evaluated with phenotypic methods (hot-cold effect, reverse CAMP test). In order to determine the hlb gene presence (coding for β-haemolysin) in a genomic DNA, PCR reactions were conducted with two different pairs of primers: one described in the literature for Staphylococcus aureus and recommended for analysing SIG group staphylococci and newly designed one in CLC Main Workbench software. Only reactions with newly designed primers resulted in product amplification, the presence of which was fully compatible with the results of phenotypic β-haemolysin test. Negative results for S. aureus and S. intermedius reference ATCC strains suggest that after further analysis the fragment of hlb gene amplified with primers described in this study might be included in the process of S. pseudintermedius strains identification.

Safety philosophy of gas turbine high temperature reactor (GTHTR300)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Shoji Katanishi; Kazuhiko Kunitomi; Shusaku Shiozawa

2002-07-01

Japan Atomic Energy Research Institute (JAERI) has undertaken the study of an original design concept of gas turbine high temperature reactor, the GTHTR300. The general concept of this study is development of a greatly simplified design that leads to substantially reduced technical and cost requirements. Newly proposed design features enable the GTHTR300 to be an efficient and economically competitive reactor in 2010's. Also, the GTHTR300 fully takes advantage of its inherent safety characteristics. The safety philosophy of the GTHTR300 is developed based on the HTTR (High Temperature Engineering Test Reactor) of JAERI which is the first HTGR in Japan. Majormore » features of the newly proposed safety philosophy for the GTHTR300 are described in this article. (authors)« less

Cooling characteristics of air cooled radial turbine blades

NASA Astrophysics Data System (ADS)

Sato, T.; Takeishi, K.; Matsuura, M.; Miyauchi, J.

The cooling design and the cooling characteristics of air cooled radial turbine wheels, which are designed for use with the gas generator turbine for the 400 horse power truck gas turbine engine, are presented. A high temperature and high speed test was performed under aerodynamically similar conditions to that of the prototype engine in order to confirm the metal temperature of the newly developed integrated casting wheels constructed of the superalloys INCO 713C. The test results compared with the analytical value, which was established on the basis of the results of the heat transfer test and the water flow test, are discussed.

CRASHWORTHY TROOP SEAT INVESTIGATION

DTIC Science & Technology

1974-12-01

helicopter structure and landing gear. Newly de - signed helicopters will have landing gear designed to with- stand high sink rates and structure whioh provides...when there is no ___ ditb i- the-restrant s tystem s p§’-Hardware components sAiall carry the restraint harness design loads without permanent de ...Specification can be accepted, a troop seat design must be tested to demonstrate compliance with the proposed draft General Military Specification. Such

The NASA computer aided design and test system

NASA Technical Reports Server (NTRS)

Gould, J. M.; Juergensen, K.

1973-01-01

A family of computer programs facilitating the design, layout, evaluation, and testing of digital electronic circuitry is described. CADAT (computer aided design and test system) is intended for use by NASA and its contractors and is aimed predominantly at providing cost effective microelectronic subsystems based on custom designed metal oxide semiconductor (MOS) large scale integrated circuits (LSIC's). CADAT software can be easily adopted by installations with a wide variety of computer hardware configurations. Its structure permits ease of update to more powerful component programs and to newly emerging LSIC technologies. The components of the CADAT system are described stressing the interaction of programs rather than detail of coding or algorithms. The CADAT system provides computer aids to derive and document the design intent, includes powerful automatic layout software, permits detailed geometry checks and performance simulation based on mask data, and furnishes test pattern sequences for hardware testing.

Variable-thermoinsulation garments with a microprocessor temperature controller.

PubMed

Kurczewska, Agnieszka; Leánikowski, Jacek

2008-01-01

This paper presents the concept of active variable thermoinsulation clothing for users working in low temperatures. Those garments contain heating inserts regulated by a microprocessor temperature controller. This paper also presents the results of tests carried out on the newly designed garments.

Design and operation of interconnectors for solid oxide fuel cell stacks

NASA Astrophysics Data System (ADS)

Winkler, W.; Koeppen, J.

Highly efficient combined cycles with solid oxide fuel cell (SOFC) need an integrated heat exchanger in the stack to reach efficiencies of about 80%. The stack costs must be lower than 1000 DM/kW. A newly developed welded metallic (Haynes HA 230) interconnector with a free stretching planar SOFC and an integrated heat exchanger was tested in thermal cycling operation. The design allowed a cycling of the SOFC without mechanical damage of the electrolyte in several tests. However, more tests and a further design optimization will be necessary. These results could indicate that commercial high-temperature alloys can be used as interconnector material in order to fullfil the cost requirements.

New Technique for Tibiotalar Arthrodesis Using a New Intramedullary Nail Device: A Cadaveric Study

PubMed Central

Eisenstein, Emmanuel D.; Rodriguez, Mario

2016-01-01

Introduction. Ankle arthrodesis is performed in a variety of methods. We propose a new technique for tibiotalar arthrodesis using a newly designed intramedullary nail. Methods. We proposed development of an intramedullary device for ankle arthrodesis which spared the subtalar joint using a sinus tarsi approach. Standard saw bones models and computer assisted modeling and stress analysis were used to develop different nail design geometries and determine the feasibility of insertion. After the final design was constructed, the device was tested on three cadaveric specimens. Results. Four basic nail geometries were developed. The optimal design was composed of two relatively straight segments, each with a different radius of curvature for their respective tibial and talar component. We successfully implemented this design into three cadaveric specimens. Conclusion. Our newly designed tibiotalar nail provides a new technique for isolated tibiotalar fusion. It utilizes the advantages of a tibiotalar calcaneal nail and spares the subtalar joint. This design serves as the foundation for future research to include compression options across the tibiotalar joint and eventual transition to clinical practice. PMID:27818800

New Technique for Tibiotalar Arthrodesis Using a New Intramedullary Nail Device: A Cadaveric Study.

PubMed

Eisenstein, Emmanuel D; Rodriguez, Mario; Abdelgawad, Amr A

2016-01-01

Introduction . Ankle arthrodesis is performed in a variety of methods. We propose a new technique for tibiotalar arthrodesis using a newly designed intramedullary nail. Methods . We proposed development of an intramedullary device for ankle arthrodesis which spared the subtalar joint using a sinus tarsi approach. Standard saw bones models and computer assisted modeling and stress analysis were used to develop different nail design geometries and determine the feasibility of insertion. After the final design was constructed, the device was tested on three cadaveric specimens. Results . Four basic nail geometries were developed. The optimal design was composed of two relatively straight segments, each with a different radius of curvature for their respective tibial and talar component. We successfully implemented this design into three cadaveric specimens. Conclusion . Our newly designed tibiotalar nail provides a new technique for isolated tibiotalar fusion. It utilizes the advantages of a tibiotalar calcaneal nail and spares the subtalar joint. This design serves as the foundation for future research to include compression options across the tibiotalar joint and eventual transition to clinical practice.

Effects of myopic spectacle correction and radial refractive gradient spectacles on peripheral refraction.

PubMed

Tabernero, Juan; Vazquez, Daniel; Seidemann, Anne; Uttenweiler, Dietmar; Schaeffel, Frank

2009-08-01

The recent observation that central refractive development might be controlled by the refractive errors in the periphery, also in primates, revived the interest in the peripheral optics of the eye. We optimized an eccentric photorefractor to measure the peripheral refractive error in the vertical pupil meridian over the horizontal visual field (from -45 degrees to 45 degrees ), with and without myopic spectacle correction. Furthermore, a newly designed radial refractive gradient lens (RRG lens) that induces increasing myopia in all radial directions from the center was tested. We found that for the geometry of our measurement setup conventional spectacles induced significant relative hyperopia in the periphery, although its magnitude varied greatly among different spectacle designs and subjects. In contrast, the newly designed RRG lens induced relative peripheral myopia. These results are of interest to analyze the effect that different optical corrections might have on the emmetropization process.

Microbiological evaluation of a newly designed dental air-turbine handpiece for anti-cross contaminations.

PubMed

Ohsuka, S; Ohta, M; Masuda, K; Kaneda, T; Ueda, M

1994-01-01

The effectiveness of a newly developed anti-cross contamination device for a dental air-turbine handpiece was tested. The handpiece with or without the anti-cross contamination device was contaminated with two bacterial strains, Staphylococcus aureus and Streptococcus mutans, as well as two bacteriophage strains, T2 and MS2. After contamination with these microorganisms, the handpieces were disinfected with glutaraldehyde or replaced with newly autoclaved ones. Residual microorganisms inside the handpiece or an air/water supply hose line were collected and counted after overnight cultivation. The anti-cross contamination device effectively reduced the contamination level of an air-turbine handpiece to that of the negative control. No microbial contamination in the air/water supply hose line was detected with this device.

Evaluation of a knee-kicker bumper design for reducing knee morbidity among carpet layers.

PubMed

Huang, Wan-Fu; Wu, Chih-Fu

2012-09-01

Carpet layers have a high prevalence of occupational knee morbidity. One of the main causes is that they need to frequently 'kick' the bumper on the rear end of the knee kicker with one knee when laying a carpet. Considering the bumper's marked effects on kicking force transmission and safety, this study aims to improve the design of the knee-kicker bumper by reducing the risk factors. An improved pendulum-type impact-testing platform was designed as an evaluative apparatus, with the impulse and the coefficient of restitution serving as evaluative criteria. The newly developed bumper has improved firmness from drilled blind holes and an increase in effective forward force of 15%-138%, which implies lower operational demands and a lighter knee burden (i.e., less kicking energy results in the same work efficiency), and a softer contact surface that enhances operating comfort. The newly designed kicker was positively reviewed by subjects. Crown Copyright © 2012. Published by Elsevier Ltd. All rights reserved.

Assessing the Treatment Effects in Apraxia of Speech: Introduction and Evaluation of the Modified Diadochokinesis Test

ERIC Educational Resources Information Center

Hurkmans, Joost; Jonkers, Roel; Boonstra, Anne M.; Stewart, Roy E.; Reinders-Messelink, Heleen A.

2012-01-01

Background: The number of reliable and valid instruments to measure the effects of therapy in apraxia of speech (AoS) is limited. Aims: To evaluate the newly developed Modified Diadochokinesis Test (MDT), which is a task to assess the effects of rate and rhythm therapies for AoS in a multiple baseline across behaviours design. Methods: The…

Performance evaluation of a newly developed variable rate sprayer for nursery liner applications

USDA-ARS?s Scientific Manuscript database

An experimental variable-rate sprayer designed for liner applications was tested by comparing its spray deposit, coverage, and droplet density inside canopies of six nursery liner varieties with constant-rate applications. Spray samplers, including water sensitive papers (WSP) and nylon screens, wer...

Preliminary study for a newly designed silicone stent and delivery system for canine obstructive tracheal disease.

PubMed

Kim, Dae-Hyun; Choi, Chi-Bong; Chung, Wook-Hun; Lee, Sung-Ho; Lee, A-Jin; Jeong, Jae-Seung; Kim, Ho-Joong; Kim, Hwi-Yool

2012-10-01

The goal of this study was to prove the possibility of using silicone stents broadly used for human medicine in canine obstructive tracheal disease. A silicone stent anatomically designed for canine trachea was tested on 5 beagle dogs for 8 weeks. The stent was carefully inserted using a newly developed delivery device under fluoroscopic guidance. There were no technical difficulties in placing the stent during the procedure. Previously reported complications of airway stenting such as stent migration or granulation tissue formation did not occur in any of the cases. In addition, removal of the stent was as simple as inserting it, and complications were absent. The stent introduced in this study could possibly be applied to various canine obstructive tracheal diseases.

Validity of a Newly-Designed Rectilinear Stepping Ergometer Submaximal Exercise Test to Assess Cardiorespiratory Fitness.

PubMed

Zhang, Rubin; Zhan, Likui; Sun, Shaoming; Peng, Wei; Sun, Yining

2017-09-01

The maximum oxygen uptake (V̇O 2 max), determined from graded maximal or submaximal exercise tests, is used to classify the cardiorespiratory fitness level of individuals. The purpose of this study was to examine the validity and reliability of the YMCA submaximal exercise test protocol performed on a newly-designed rectilinear stepping ergometer (RSE) that used up and down reciprocating vertical motion in place of conventional circular motion and giving precise measurement of workload, to determine V̇O 2 max in young healthy male adults. Thirty-two young healthy male adults (32 males; age range: 20-35 years; height: 1.75 ± 0.05 m; weight: 67.5 ± 8.6 kg) firstly participated in a maximal-effort graded exercise test using a cycle ergometer (CE) to directly obtain measured V̇O 2 max. Subjects then completed the progressive multistage test on the RSE beginning at 50W and including additional stages of 70, 90, 110, 130, and 150W, and the RSE YMCA submaximal test consisting of a workload increase every 3 minutes until the termination criterion was reached. A metabolic equation was derived from the RSE multistage exercise test to predict oxygen consumption (V̇O 2 ) from power output (W) during the submaximal exercise test (V̇O 2 (mL·min -1 )=12.4 ×W(watts)+3.5 mL·kg -1 ·min -1 ×M+160mL·min -1 , R 2 = 0.91, standard error of the estimate (SEE) = 134.8mL·min -1 ). A high correlation was observed between the RSE YMCA estimated V̇O 2 max and the CE measured V̇O 2 max (r=0.87). The mean difference between estimated and measured V̇O 2 max was 2.5 mL·kg -1 ·min -1 , with an SEE of 3.55 mL·kg -1 ·min -1 . The data suggest that the RSE YMCA submaximal exercise test is valid for predicting V̇O 2 max in young healthy male adults. The findings show that the rectilinear stepping exercise is an effective submaximal exercise for predicting V̇O 2 max. The newly-designed RSE may be potentially further developed as an alternative ergometer for assessing cardiorespiratory fitness and the promotion of personalized health interventions for health care professionals.

16 CFR 255.5 - Disclosure of material connections.

Code of Federal Regulations, 2010 CFR

2010-01-01

... examples below. Example 1: A drug company commissions research on its product by an outside organization. The drug company determines the overall subject of the research (e.g., to test the efficacy of a newly.... Although the design and conduct of the research project are controlled by the outside research organization...

SEWER SEDIMENT GATE AND VACUUM FLUSHING TANKS: LABORATORY FLUME STUDIES

EPA Science Inventory

The objective of this study was to test the performance of a traditional gate-flushing device and a newly designed vacuum-flushing device in removing sediments from combined sewers and CSO storage tanks. A laboratory hydraulic flune was used to simulate a reach of sewer or storag...

Vibro-acoustic performance of newly designed tram track structures

NASA Astrophysics Data System (ADS)

Haladin, Ivo; Lakušić, Stjepan; Ahac, Maja

2017-09-01

Rail vehicles in interaction with a railway structure induce vibrations that are propagating to surrounding structures and cause noise disturbance in the surrounding areas. Since tram tracks in urban areas often share the running surface with road vehicles one of top priorities is to achieve low maintenance and long lasting structure. Research conducted in scope of this paper gives an overview of newly designed tram track structures designated for use on Zagreb tram network and their performance in terms of noise and vibration mitigation. Research has been conducted on a 150 m long test section consisted of three tram track types: standard tram track structure commonly used on tram lines in Zagreb, optimized tram structure for better noise and vibration mitigation and a slab track with double sleepers embedded in a concrete slab, which presents an entirely new approach of tram track construction in Zagreb. Track has been instrumented with acceleration sensors, strain gauges and revision shafts for inspection. Relative deformations give an insight into track structure dynamic load distribution through the exploitation period. Further the paper describes vibro-acoustic measurements conducted at the test site. To evaluate the track performance from the vibro-acoustical standpoint, detailed analysis of track decay rate has been analysed. Opposed to measurement technique using impact hammer for track decay rate measurements, newly developed measuring technique using vehicle pass by vibrations as a source of excitation has been proposed and analysed. Paper gives overview of the method, it’s benefits compared to standard method of track decay rate measurements and method evaluation based on noise measurements of the vehicle pass by.

Feasibility and Preliminary Effects of an Intervention Targeting Schema Development for Caregivers of Newly Admitted Hospice Patients

PubMed Central

Mazurek Melnyk, Bernadette

2013-01-01

Abstract Background The transition to hospice care is a stressful experience for caregivers, who report high anxiety, unpreparedness, and lack of confidence. These sequelae are likely explained by the lack of an accurate cognitive schema, not knowing what to expect or how to help their loved one. Few interventions exist for this population and most do not measure preparedness, confidence, and anxiety using a schema building a conceptual framework for a new experience. Objective The purpose of this study was to test the feasibility and preliminary effects of an intervention program, Education and Skill building Intervention for Caregivers of Hospice patients (ESI-CH), using an innovative conceptual design that targets cognitive schema development and basic skill building for caregivers of loved ones newly admitted to hospice services. Design A pre-experimental one-group pre- and post-test study design was used. Eighteen caregivers caring for loved ones in their homes were recruited and twelve completed the pilot study. Depression, anxiety, activity restriction, preparedness, and beliefs/confidence were measured. Results Caregivers reported increased preparedness, more helpful beliefs, and more confidence about their ability to care for their loved one. Preliminary trends suggested decreased anxiety levels for the intervention group. Caregivers who completed the intervention program rated the program very good or excellent, thought the information was helpful and timely, and would recommend it to friends. Conclusions Results show promise that the ESI-CH program may assist as an evidence-based program to support caregivers in their role as a caregiver to a newly admitted hospice patient. PMID:23384244

Experimental investigation of an ejector-powered free-jet facility

NASA Technical Reports Server (NTRS)

Long, Mary JO

1992-01-01

NASA Lewis Research Center's (LeRC) newly developed Nozzle Acoustic Test Rig (NATR) is a large free-jet test facility powered by an ejector system. In order to assess the pumping performance of this ejector concept and determine its sensitivity to various design parameters, a 1/5-scale model of the NATR was built and tested prior to the operation of the actual facility. This paper discusses the results of the 1/5-scale model tests and compares them with the findings from the full-scale tests.

Buckling Test Results and Preliminary Test and Analysis Correlation from the 8-Foot-Diameter Orthogrid-Stiffened Cylinder Test Article TA02

NASA Technical Reports Server (NTRS)

Hilburger, Mark W.; Waters, W. Allen, Jr.; Haynie, Waddy T.; Thornburgh, Robert P

2017-01-01

Results from the testing of cylinder test article SBKF-P2-CYL-TA02 (referred to herein as TA02) are presented. TA02 is an 8-foot-diameter (96-inches), 78.0-inch-long, aluminum-lithium (Al-Li), orthogrid-stiffened cylindrical shell similar to those used in current state-of-the-art launch-vehicle structures and was designed to exhibit global buckling when subjected to combined compression and bending loads. The testing was conducted at the Marshall Space Flight Center (MSFC), February 3-6, 2009, in support of the Shell Buckling Knockdown Factor Project (SBKF). The test was used to verify the performance of a newly constructed buckling test facility at MSFC and to verify the test article design and analysis approach used by the SBKF researchers.

Safety evaluation of large external fixation clamps and frames in a magnetic resonance environment.

PubMed

Luechinger, Roger; Boesiger, Peter; Disegi, John A

2007-07-01

Large orthopedic external fixation clamps and related components were evaluated for force, torque, and heating response when subjected to the strong electromagnetic fields of magnetic-resonance (MR) imaging devices. Forces induced by a 3-Tesla (T) MR scanner were compiled for newly designed nonmagnetic clamps and older clamps that contained ferromagnetic components. Heating trials were performed in a 1.5 and in a 3 T MR scanner with two assembled external fixation frames. Forces of the newly designed clamps were more than a factor 2 lower as the gravitational force on the device whereas, magnetic forces on the older devices showed over 10 times the force induced by earth acceleration of gravity. No torque effects could be found for the newly designed clamps. Temperature measurements at the tips of Schanz screws in the 1.5 T MR scanner showed a rise of 0.7 degrees C for a pelvic frame and of 2.1 degrees C for a diamond knee bridge frame when normalized to a specific absorption rate (SAR) of 2 W/kg. The normalized temperature increases in the 3 T MR scanner were 0.9 degrees C for the pelvic frame and 1.1 degrees C for the knee bridge frame. Large external fixation frames assembled with the newly designed clamps (390 Series Clamps), carbon fiber reinforced rods, and implant quality 316L stainless steel Schanz screws met prevailing force and torque limits when tested in a 3-T field, and demonstrated temperature increase that met IEC-60601 guidelines for extremities. The influence of frame-induced eddy currents on the risk of peripheral nerve stimulation was not investigated. Copyright 2006 Wiley Periodicals, Inc.

Assessment of increased sampling pump flow rates in a disposable, inhalable aerosol sampler

PubMed Central

Stewart, Justin; Sleeth, Darrah K.; Handy, Rod G.; Pahler, Leon F.; Anthony, T. Renee; Volckens, John

2017-01-01

A newly designed, low-cost, disposable inhalable aerosol sampler was developed to assess workers personal exposure to inhalable particles. This sampler was originally designed to operate at 10 L/min to increase sample mass and, therefore, improve analytical detection limits for filter-based methods. Computational fluid dynamics modeling revealed that sampler performance (relative to aerosol inhalability criteria) would not differ substantially at sampler flows of 2 and 10 L/min. With this in mind, the newly designed inhalable aerosol sampler was tested in a wind tunnel, simultaneously, at flows of 2 and 10 L/min flow. A mannequin was equipped with 6 sampler/pump assemblies (three pumps operated at 2 L/min and three pumps at 10 L/min) inside a wind tunnel, operated at 0.2 m/s, which has been shown to be a typical indoor workplace wind speed. In separate tests, four different particle sizes were injected to determine if the sampler’s performance with the new 10 L/min flow rate significantly differed to that at 2 L/min. A comparison between inhalable mass concentrations using a Wilcoxon signed rank test found no significant difference in the concentration of particles sampled at 10 and 2 L/min for all particle sizes tested. Our results suggest that this new aerosol sampler is a versatile tool that can improve exposure assessment capabilities for the practicing industrial hygienist by improving the limit of detection and allowing for shorting sampling times. PMID:27676440

Assessment of increased sampling pump flow rates in a disposable, inhalable aerosol sampler.

PubMed

Stewart, Justin; Sleeth, Darrah K; Handy, Rod G; Pahler, Leon F; Anthony, T Renee; Volckens, John

2017-03-01

A newly designed, low-cost, disposable inhalable aerosol sampler was developed to assess workers personal exposure to inhalable particles. This sampler was originally designed to operate at 10 L/min to increase sample mass and, therefore, improve analytical detection limits for filter-based methods. Computational fluid dynamics modeling revealed that sampler performance (relative to aerosol inhalability criteria) would not differ substantially at sampler flows of 2 and 10 L/min. With this in mind, the newly designed inhalable aerosol sampler was tested in a wind tunnel, simultaneously, at flows of 2 and 10 L/min flow. A mannequin was equipped with 6 sampler/pump assemblies (three pumps operated at 2 L/min and three pumps at 10 L/min) inside a wind tunnel, operated at 0.2 m/s, which has been shown to be a typical indoor workplace wind speed. In separate tests, four different particle sizes were injected to determine if the sampler's performance with the new 10 L/min flow rate significantly differed to that at 2 L/min. A comparison between inhalable mass concentrations using a Wilcoxon signed rank test found no significant difference in the concentration of particles sampled at 10 and 2 L/min for all particle sizes tested. Our results suggest that this new aerosol sampler is a versatile tool that can improve exposure assessment capabilities for the practicing industrial hygienist by improving the limit of detection and allowing for shorting sampling times.

33 CFR 150.515 - What are the requirements for weight testing of newly installed or relocated craft?

Code of Federal Regulations, 2010 CFR

2010-07-01

... weight testing of newly installed or relocated craft? 150.515 Section 150.515 Navigation and Navigable... testing of newly installed or relocated craft? (a) The operator must perform installation weight testing... (a) of this section, when survival crafts are relocated to another deepwater port. ...

Pressure variation of developed lapping tool on surface roughness

NASA Astrophysics Data System (ADS)

Hussain, A. K.; Lee, K. Q.; Aung, L. M.; Abu, A.; Tan, L. K.; Kang, H. S.

2018-01-01

Improving the surface roughness is always one of the major concerns in the development of lapping process as high precision machining caters a great demand in manufacturing process. This paper aims to investigate the performance of a newly designed lapping tool in term of surface roughness. Polypropylene is used as the lapping tool head. The lapping tool is tested for different pressure to identify the optimum working pressure for lapping process. The theoretical surface roughness is also calculated using Vickers Hardness. The present study shows that polypropylene is able to produce good quality and smooth surface roughness. The optimum lapping pressure in the present study is found to be 45 MPa. By comparing the theoretical and experimental values, the present study shows that the newly designed lapping tool is capable to produce finer surface roughness.

Intelligent Engine Systems: Bearing System

NASA Technical Reports Server (NTRS)

Singh, Arnant P.

2008-01-01

The overall requirements necessary for sensing bearing distress and the related criteria to select a particular rotating sensor were established during the phase I. The current phase II efforts performed studies to evaluate the Robustness and Durability Enhancement of the rotating sensors, and to design, and develop the Built-in Telemetry System concepts for an aircraft engine differential sump. A generic test vehicle that can test the proposed bearing diagnostic system was designed, developed, and built. The Timken Company, who also assisted with testing the GE concept of using rotating sensors for the differential bearing diagnostics during previous phase, was selected as a subcontractor to assist General Electric (GE) for the design, and procurement of the test vehicle. A purchase order was prepared to define the different sub-tasks, and deliverables for this task. The University of Akron was selected to provide the necessary support for installing, and integrating the test vehicle with their newly designed test facility capable of simulating the operating environment for the planned testing. The planned testing with good and damaged bearings will be on hold pending further continuation of this effort during next phase.

Development and flight test results of an autothrottle control system at Mach 3 cruise

NASA Technical Reports Server (NTRS)

Gilyard, G. B.; Burken, J. J.

1980-01-01

Flight test results obtained with the original Mach hold autopilot designed the YF-12C airplane which uses elevator control and a newly developed Mach hold system having an autothrottle integrated with an altitude hold autopilot system are presented. The autothrottle tests demonstrate good speed control at high Mach numbers and high altitudes while simultaneously maintaining control over altitude and good ride qualities. The autothrottle system was designed to control either Mach number or knots equivalent airspeed (KEAS). Excellent control of Mach number or KEAS was obtained with the autothrottle system when combined with altitude hold. Ride qualities were significantly better than with the conventional Mach hold system.

The magic shrinking machine revisited: The presence of props at recall facilitates memory in 3-year-olds.

PubMed

Dahl, Jonna J; Kingo, Osman S; Krøjgaard, Peter

2015-12-01

In a seminal study Simcock and Hayne (2002) showed that 3-year-olds were unable to use newly acquired words to describe a "magic" event experienced 6 or 12 months earlier. In the reference study the children's verbal recall was tested without props being present. Inspired by recent evidence, the original design was replicated, testing 33-and 39-month-olds (n = 180), but with props present at recall while controlling for potential online reasoning. The results revealed that the children did use newly acquired words to describe their preverbal memory. Thus, the present study shows that nonverbal memories can be verbalized if the recall setting provides a high level of contextual support, a finding relevant to researchers investigating the offset of childhood amnesia. (c) 2015 APA, all rights reserved).

Design of an MR image processing module on an FPGA chip

NASA Astrophysics Data System (ADS)

Li, Limin; Wyrwicz, Alice M.

2015-06-01

We describe the design and implementation of an image processing module on a single-chip Field-Programmable Gate Array (FPGA) for real-time image processing. We also demonstrate that through graphical coding the design work can be greatly simplified. The processing module is based on a 2D FFT core. Our design is distinguished from previously reported designs in two respects. No off-chip hardware resources are required, which increases portability of the core. Direct matrix transposition usually required for execution of 2D FFT is completely avoided using our newly-designed address generation unit, which saves considerable on-chip block RAMs and clock cycles. The image processing module was tested by reconstructing multi-slice MR images from both phantom and animal data. The tests on static data show that the processing module is capable of reconstructing 128 × 128 images at speed of 400 frames/second. The tests on simulated real-time streaming data demonstrate that the module works properly under the timing conditions necessary for MRI experiments.

Design of an MR image processing module on an FPGA chip

PubMed Central

Li, Limin; Wyrwicz, Alice M.

2015-01-01

We describe the design and implementation of an image processing module on a single-chip Field-Programmable Gate Array (FPGA) for real-time image processing. We also demonstrate that through graphical coding the design work can be greatly simplified. The processing module is based on a 2D FFT core. Our design is distinguished from previously reported designs in two respects. No off-chip hardware resources are required, which increases portability of the core. Direct matrix transposition usually required for execution of 2D FFT is completely avoided using our newly-designed address generation unit, which saves considerable on-chip block RAMs and clock cycles. The image processing module was tested by reconstructing multi-slice MR images from both phantom and animal data. The tests on static data show that the processing module is capable of reconstructing 128 × 128 images at speed of 400 frames/second. The tests on simulated real-time streaming data demonstrate that the module works properly under the timing conditions necessary for MRI experiments. PMID:25909646

76 FR 7241 - Additional Designation of Entities Pursuant to Executive Order 13382

Federal Register 2010, 2011, 2012, 2013, 2014

2011-02-09

... DEPARTMENT OF THE TREASURY Office of Foreign Assets Control Additional Designation of Entities... 4 newly-designated entities and one newly-designated individual whose property and interests in... of the 4 entities and one individual identified in this notice pursuant to Executive Order 13382 is...

75 FR 70352 - Additional Designation of Entities Pursuant to Executive Order 13382

Federal Register 2010, 2011, 2012, 2013, 2014

2010-11-17

... DEPARTMENT OF THE TREASURY Office of Foreign Assets Control Additional Designation of Entities... 37 newly-designated entities and 5 newly-designated individuals whose property and interests in... of the 37 entities and 5 individuals identified in this notice pursuant to Executive Order 13382 is...

Applicability of out-of-pile fretting wear tests to in-reactor fretting wear-induced failure time prediction

NASA Astrophysics Data System (ADS)

Kim, Kyu-Tae

2013-02-01

In order to investigate whether or not the grid-to-rod fretting wear-induced fuel failure will occur for newly developed spacer grid spring designs for the fuel lifetime, out-of-pile fretting wear tests with one or two fuel assemblies are to be performed. In this study, the out-of-pile fretting wear tests were performed in order to compare the potential for wear-induced fuel failure in two newly-developed, Korean PWR spacer grid designs. Lasting 20 days, the tests simulated maximum grid-to-rod gap conditions and the worst flow induced vibration effects that might take place over the fuel life time. The fuel rod perforation times calculated from the out-of-pile tests are greater than 1933 days for 2 μm oxidized fuel rods with a 100 μm grid-to-rod gap, whereas those estimated from in-reactor fretting wear failure database may be about in the range of between 60 and 100 days. This large discrepancy in fuel rod perforation may occur due to irradiation-induced cladding oxide microstructure changes on the one hand and a temperature gradient-induced hydrogen content profile across the cladding metal region on the other hand, which may accelerate brittleness in the grid-contacting cladding oxide and metal regions during the reactor operation. A three-phase grid-to-rod fretting wear model is proposed to simulate in-reactor fretting wear progress into the cladding, considering the microstructure changes of the cladding oxide and the hydrogen content profile across the cladding metal region combined with the temperature gradient. The out-of-pile tests cannot be directly applicable to the prediction of in-reactor fretting wear-induced cladding perforations but they can be used only for evaluating a relative wear resistance of one grid design against the other grid design.

Efficacy of a Newly Designed Cephalometric Analysis Software for McNamara Analysis in Comparison with Dolphin Software.

PubMed

Nouri, Mahtab; Hamidiaval, Shadi; Akbarzadeh Baghban, Alireza; Basafa, Mohammad; Fahim, Mohammad

2015-01-01

Cephalometric norms of McNamara analysis have been studied in various populations due to their optimal efficiency. Dolphin cephalometric software greatly enhances the conduction of this analysis for orthodontic measurements. However, Dolphin is very expensive and cannot be afforded by many clinicians in developing countries. A suitable alternative software program in Farsi/English will greatly help Farsi speaking clinicians. The present study aimed to develop an affordable Iranian cephalometric analysis software program and compare it with Dolphin, the standard software available on the market for cephalometric analysis. In this diagnostic, descriptive study, 150 lateral cephalograms of normal occlusion individuals were selected in Mashhad and Qazvin, two major cities of Iran mainly populated with Fars ethnicity, the main Iranian ethnic group. After tracing the cephalograms, the McNamara analysis standards were measured both with Dolphin and the new software. The cephalometric software was designed using Microsoft Visual C++ program in Windows XP. Measurements made with the new software were compared with those of Dolphin software on both series of cephalograms. The validity and reliability were tested using intra-class correlation coefficient. Calculations showed a very high correlation between the results of the Iranian cephalometric analysis software and Dolphin. This confirms the validity and optimal efficacy of the newly designed software (ICC 0.570-1.0). According to our results, the newly designed software has acceptable validity and reliability and can be used for orthodontic diagnosis, treatment planning and assessment of treatment outcome.

Primary aldosteronism among newly diagnosed and untreated hypertensive patients in a Swedish primary care area

PubMed Central

Westerdahl, Christina; Bergenfelz, Anders; Isaksson, Anders; Nerbrand, Christina; Valdemarsson, Stig

2011-01-01

Objective To evaluate the prevalence of primary aldosteronism (PA) in newly diagnosed and untreated hypertensive patients in primary care using the aldosterone/renin ratio (ARR), and to assess clinical and biochemical characteristics in patients with high and normal ARR. Design Patient survey study. Setting and subjects A total of 200 consecutive patients with newly diagnosed and untreated hypertension from six primary health care centres in Sweden were included. Main outcome measures ARR was calculated from serum aldosterone and plasma renin concentrations. The cut-off level for ARR was 65. Patients with an increased ARR were considered for confirmatory testing with the fludrocortisone suppression test (FST), followed by adrenal computed tomographic radiology (CT) and adrenal venous sampling (AVS). Results Of 200 patients, 36 patients had an ARR > 65. Of these 36 patients, 11 patients had an incomplete aldosterone inhibition during FST. Three patients were diagnosed with an aldosterone producing adenoma (APA) and eight with bilateral adrenal hyperplasia (BHA). Except for moderately lower level of P-K in patients with an ARR > 65 and in patients with PA, there were no biochemical or clinical differences found among hypertensive patients with PA compared with patients without PA. Conclusion Eleven of 200 evaluated patients (5.5%) were considered to have PA. The diagnosis of PA should therefore be considered in newly diagnosed hypertensive subjects and screening for the diagnosis is warranted. PMID:21323498

Bayesian Adaptive Trial Design for a Newly Validated Surrogate Endpoint

PubMed Central

Renfro, Lindsay A.; Carlin, Bradley P.; Sargent, Daniel J.

2011-01-01

Summary The evaluation of surrogate endpoints for primary use in future clinical trials is an increasingly important research area, due to demands for more efficient trials coupled with recent regulatory acceptance of some surrogates as ‘valid.’ However, little consideration has been given to how a trial which utilizes a newly-validated surrogate endpoint as its primary endpoint might be appropriately designed. We propose a novel Bayesian adaptive trial design that allows the new surrogate endpoint to play a dominant role in assessing the effect of an intervention, while remaining realistically cautious about its use. By incorporating multi-trial historical information on the validated relationship between the surrogate and clinical endpoints, then subsequently evaluating accumulating data against this relationship as the new trial progresses, we adaptively guard against an erroneous assessment of treatment based upon a truly invalid surrogate. When the joint outcomes in the new trial seem plausible given similar historical trials, we proceed with the surrogate endpoint as the primary endpoint, and do so adaptively–perhaps stopping the trial for early success or inferiority of the experimental treatment, or for futility. Otherwise, we discard the surrogate and switch adaptive determinations to the original primary endpoint. We use simulation to test the operating characteristics of this new design compared to a standard O’Brien-Fleming approach, as well as the ability of our design to discriminate trustworthy from untrustworthy surrogates in hypothetical future trials. Furthermore, we investigate possible benefits using patient-level data from 18 adjuvant therapy trials in colon cancer, where disease-free survival is considered a newly-validated surrogate endpoint for overall survival. PMID:21838811

The development and impact of active learning strategies on self-confidence in a newly designed first-year self-care pharmacy course - outcomes and experiences.

PubMed

Smith, Kathryn J; Grundmann, Oliver; Li, Robin Moorman

2018-04-01

The primary objective of this investigation was to determine the effectiveness of different active learning exercises in a newly-designed flipped-classroom self-care course in applying newly acquired knowledge of self-care and improving the confidence of first-year pharmacy students to recommend self-care treatments and counsel patients. The early development of these skills is essential for the subsequent Community Introductory Pharmacy Practice Experience (CIPPE). An unpaired anonymous survey was administered to students, pre- and post-course, to ascertain their opinions on the effectiveness of various teaching strategies and active learning exercises on learning and on their confidence in treatment-planning and patient counseling for self-care patients. Comparison between pre- and post-course Likert scores was conducted using a one-way ANOVA followed by a post-hoc Tukey's test with significance at p = 0.05. All other tests of significance were conducted using a student's t-test with significance at p = 0.05. Students' self-confidence in developing treatment plans and in counseling for non-prescription drugs and dietary supplements significantly improved from the beginning to the end of this self-care course. The response rate was high in both the pre- (N = 208, 88.1%) and post- (N = 198, 83.9%) course surveys. The positive change in confidence was not reflected in increased performance on the final exam represented by a lower average score than the midterm exam. Active learning sessions and the flipped classroom approach in this first-year pharmacy self-care course contributed to increased self-confidence in making recommendations and counseling patients on proper use of nonprescription medications and dietary supplements. Copyright © 2017 Elsevier Inc. All rights reserved.

Flight test validation of a design procedure for digital autopilots

NASA Technical Reports Server (NTRS)

Bryant, W. H.

1983-01-01

Commercially available general aviation autopilots are currently in transition from an analogue circuit system to a computer implemented digital flight control system. Well known advantages of the digital autopilot include enhanced modes, self-test capacity, fault detection, and greater computational capacity. A digital autopilot's computational capacity can be used to full advantage by increasing the sophistication of the digital autopilot's chief function, stability and control. NASA's Langley Research Center has been pursuing the development of direct digital design tools for aircraft stabilization systems for several years. This effort has most recently been directed towards the development and realization of multi-mode digital autopilots for GA aircraft, conducted under a SPIFR-related program called the General Aviation Terminal Operations Research (GATOR) Program. This presentation focuses on the implementation and testing of a candidate multi-mode autopilot designed using these newly developed tools.

Test Review: Review of the Wechsler Abbreviated Scale of Intelligence, Second Edition (WASI-II)

ERIC Educational Resources Information Center

McCrimmon, Adam W.; Smith, Amanda D.

2013-01-01

The Wechsler Abbreviated Scale of Intelligence, Second Edition (WASI-II; Wechsler, 2011), published by Pearson, is a newly updated abbreviated measure of cognitive intelligence designed for individuals 6 to 90 years of age. Primarily used in clinical, psychoeducational, and research settings, the WASI-II was developed to quickly and accurately…

Capacitance Measurement with a Sigma Delta Converter for 3D Electrical Capacitance Tomography

NASA Technical Reports Server (NTRS)

Nurge, Mark

2005-01-01

This paper will explore suitability of a newly available capacitance to digital converter for use in a 3D Electrical Capacitance Tomography system. A switch design is presented along with circuitry needed to extend the range of the capacitance to digital converter. Results are then discussed for a 15+ hour drift and noise test.

Organotypic cultures as tools for testing neuroactive drugs - link between in-vitro and in-vivo experiments.

PubMed

Drexler, B; Hentschke, H; Antkowiak, B; Grasshoff, C

2010-01-01

The development of neuroactive drugs is a time consuming procedure. Candidate drugs must be run through a battery of tests, including receptor studies and behavioural tests on animals. As a rule, numerous substances with promising properties as assessed in receptor studies must be eliminated from the development pipeline in advanced test phases because of unforeseen problems like intolerable side-effects or unsatisfactory performance in the whole organism. Clearly, test systems of intermediate complexity would alleviate this inefficiency. In this review, we propose cultured organotypic brain slices as model systems that could bridge the 'interpolation gap' between receptors and the brain, with a focus on the development of new general anaesthetics with lesser side effects. General anaesthesia is based on the modulation of neurotransmitter receptors and other conductances located on neurons in diverse brain regions, including cerebral cortex and spinal cord. It is well known that different components of general anaesthesia, e.g. hypnosis and immobility, are produced by the depression of neuronal activity in distinct brain regions. The ventral horn of the spinal cord is an important structure for the induction of immobility. Thus, the potentially immobilizing effects of a newly designed drug can be estimated from its depressant effect on neuronal network activity in cultured spinal slices. A drug's sedative and hypnotic potential can be examined in cortical cultures. Combined with genetically engineered mice, this approach can point to receptor subtypes most relevant to the drug's intended net effect and in return can help in the design of more selective drugs. In conclusion, the use of organotypic cultures permits predictions of neuroactive properties of newly designed drugs on an intermediate level, and should therefore open up avenues for a more creative and economic drug development process.

A new bipolar Qtrim power supply system

DOE Office of Scientific and Technical Information (OSTI.GOV)

Mi, C.; Bruno, D.; Drozd, J.

2015-05-03

This year marks the 15th run of RHIC (Relativistic Heavy Ion Collider) operations. The reliability of superconducting magnet power supplies is one of the essential factors in the entire accelerator complex. Besides maintaining existing power supplies and their associated equipment, newly designed systems are also required based on the physicist’s latest requirements. A bipolar power supply was required for this year’s main quadruple trim power supply. This paper will explain the design, prototype, testing, installation and operation of this recently installed power supply system.

Agile Walker.

PubMed

Katz, Reuven

2015-01-01

The goal of the Agile Walker is to improve the outdoor mobility of healthy elderly people with some mobility limitations. It is a newly developed, all-terrain walker, equipped with an electric drive system and speed control that can assists elderly people to walk outdoors or to hike. The walker has a unique product design with an attractive look that will appeal to "active-agers" population. This paper describes product design requirements and the development process of the Agile Walker, its features and some preliminary testing results.

First results of performance tests of the newly designed Vacuum Silicon Photo Multiplier Tube (VSiPMT).

NASA Astrophysics Data System (ADS)

de Asmundis, R.; Barbarino, G.; Barbato, F. C. T.; Campajola, L.; De Rosa, G.; Fiorillo, G.; Migliozzi, P.; Mollo, C. M.; Rossi, B.; Vivolo, D.

2014-04-01

We invented (2007) the VSiPMT, a novel, high-gain, photo detector device and we publically proposed this idea in an International Conference for the first time at the 11th Topical Seminar on Innovative Particle and Radiation Detectors (IPRD08) in Siena, triggering deep discussions on the feasibility of the device itself and on the convenience of such a solution. After several years spent in designing, evaluation, tests and eventually negotiations with some suppliers, we finally got a couple of prototypes of the Vacuum Silicon Photo Multiplier Tube (VSiPMT) made under our specifications by Hamamatsu. We present in this paper the most important results of characterization tests of the first prototypes of the VSiPMT.

Utility of a Newly Designed Film Holder for Premolar Bitewing Radiography.

PubMed

Safi, Yaser; Esmaeelinejad, Mohammad; Vasegh, Zahra; Valizadeh, Solmaz; Aghdasi, Mohammad Mehdi; Sarani, Omid; Afsahi, Mahmoud

2015-11-01

Bitewing radiography is a valuable technique for assessment of proximal caries, alveolar crest and periodontal status. Technical errors during radiography result in erroneous radiographic interpretation, misdiagnosis, possible mistreatment or unnecessary exposure of patient for taking a repeat radiograph. In this study, we aimed to evaluate the efficacy of a film holder modified from the conventional one and compared it with that of conventional film holder. Our study population comprised of 70 patients who were referred to the Radiology Department for bilateral premolar bitewing radiographs as requested by their attending clinician. Bitewing radiographs in each patient were taken using the newly designed holder in one side and the conventional holder in the other side. The acceptability of the two holders from the perspectives of the technician and patients was determined using a 0-20 point scale. The frequency of overlap and film positioning errors was calculated for each method. The conventional holder had greater acceptability among patients compared to the newly designed holder (mean score of 16.59 versus 13.37). From the technicians' point of view, the newly designed holder was superior to the conventional holder (mean score of 17.33 versus 16.44). The frequency of overlap was lower using the newly designed holder (p<0.001) and it allowed more accurate film positioning (p=0.005). The newly designed holder may facilitate the process of radiography for technicians and may be associated with less frequency of radiographic errors compared to the conventional holder.

X-ray digital industrial radiography (DIR) for local liquid velocity (VLL) measurement in trickle bed reactors (TBRs): Validation of the technique

NASA Astrophysics Data System (ADS)

Mohd Salleh, Khairul Anuar; Rahman, Mohd Fitri Abdul; Lee, Hyoung Koo; Al Dahhan, Muthanna H.

2014-06-01

Local liquid velocity measurements in Trickle Bed Reactors (TBRs) are one of the essential components in its hydrodynamic studies. These measurements are used to effectively determine a reactor's operating condition. This study was conducted to validate a newly developed technique that combines Digital Industrial Radiography (DIR) with Particle Tracking Velocimetry (PTV) to measure the Local Liquid Velocity (VLL) inside TBRs. Three millimeter-sized Expanded Polystyrene (EPS) beads were used as packing material. Three validation procedures were designed to test the newly developed technique. All procedures and statistical approaches provided strong evidence that the technique can be used to measure the VLL within TBRs.

X-ray digital industrial radiography (DIR) for local liquid velocity (V(LL)) measurement in trickle bed reactors (TBRs): validation of the technique.

PubMed

Mohd Salleh, Khairul Anuar; Rahman, Mohd Fitri Abdul; Lee, Hyoung Koo; Al Dahhan, Muthanna H

2014-06-01

Local liquid velocity measurements in Trickle Bed Reactors (TBRs) are one of the essential components in its hydrodynamic studies. These measurements are used to effectively determine a reactor's operating condition. This study was conducted to validate a newly developed technique that combines Digital Industrial Radiography (DIR) with Particle Tracking Velocimetry (PTV) to measure the Local Liquid Velocity (V(LL)) inside TBRs. Three millimeter-sized Expanded Polystyrene (EPS) beads were used as packing material. Three validation procedures were designed to test the newly developed technique. All procedures and statistical approaches provided strong evidence that the technique can be used to measure the V(LL) within TBRs.

Reusable Solid Rocket Motor Nozzle Joint 5 Redesign

NASA Technical Reports Server (NTRS)

Lui, R. C.; Stratton, T. C.; LaMont, D. T.

2003-01-01

Torque tension testing of a newly designed Reusable Solid Rocket Motor nozzle bolted assembly was successfully completed. Test results showed that the 3-sigma preload variation was as expected at the required input torque level and the preload relaxation were within the engineering limits. A shim installation technique was demonstrated as a simple process to fill a shear lip gap between nozzle housings in the joint region. A new automated torque system was successfully demonstrated in this test. This torque control tool was found to be very precise and accurate. The bolted assembly performance was further evaluated using the Nozzle Structural Test Bed. Both current socket head cap screw and proposed multiphase alloy bolt configurations were tested. Results indicated that joint skip and bolt bending were significantly reduced with the new multiphase alloy bolt design. This paper summarizes all the test results completed to date.

Numerical Simulation and Mechanical Design for TPS Electron Beam Position Monitors

NASA Astrophysics Data System (ADS)

Hsueh, H. P.; Kuan, C. K.; Ueng, T. S.; Hsiung, G. Y.; Chen, J. R.

2007-01-01

Comprehensive study on the mechanical design and numerical simulation for the high resolution electron beam position monitors are key steps to build the newly proposed 3rd generation synchrotron radiation research facility, Taiwan Photon Source (TPS). With more advanced electromagnetic simulation tool like MAFIA tailored specifically for particle accelerator, the design for the high resolution electron beam position monitors can be tested in such environment before they are experimentally tested. The design goal of our high resolution electron beam position monitors is to get the best resolution through sensitivity and signal optimization. The definitions and differences between resolution and sensitivity of electron beam position monitors will be explained. The design consideration is also explained. Prototype deign has been carried out and the related simulations were also carried out with MAFIA. The results are presented here. Sensitivity as high as 200 in x direction has been achieved in x direction at 500 MHz.

Development and flight test of an experimental maneuver autopilot for a highly maneuverable aircraft

NASA Technical Reports Server (NTRS)

Duke, Eugene L.; Jones, Frank P.; Roncoli, Ralph B.

1986-01-01

This report presents the development of an experimental flight test maneuver autopilot (FTMAP) for a highly maneuverable aircraft. The essence of this technique is the application of an autopilot to provide precise control during required flight test maneuvers. This newly developed flight test technique is being applied at the Dryden Flight Research Facility of NASA Ames Research Center. The FTMAP is designed to increase the quantity and quality of data obtained in test flight. The technique was developed and demonstrated on the highly maneuverable aircraft technology (HiMAT) vehicle. This report describes the HiMAT vehicle systems, maneuver requirements, FTMAP development process, and flight results.

Design, construction and mechanical optimisation process of electrode with radial current flow in the scala tympani.

PubMed

Deman, P R; Kaiser, T M; Dirckx, J J; Offeciers, F E; Peeters, S A

2003-09-30

A 48 contact cochlear implant electrode has been constructed for electrical stimulation of the auditory nerve. The stimulating contacts of this electrode are organised in two layers: 31 contacts on the upper surface directed towards the habenula perforata and 17 contacts connected together as one longitudinal contact on the underside. The design of the electrode carrier aims to make radial current flow possible in the cochlea. The mechanical structure of the newly designed electrode was optimised to obtain maximal insertion depth. Electrode insertion tests were performed in a transparent acrylic model of the human cochlea.

Report to the U.S. Congress on the National Oceanographic Partnership Program

DTIC Science & Technology

1999-01-01

security, advancing economic development, protecting quality of life, and strengthening science education and communication through improved knowledge of... nitrate analyzers, and spectral optical sensors) will be tested on testbed moorings near Bermuda and Monterey Bay. The newly developed systems...design, systems integration, interdisciplinary multiscale data assimilation and interactive processes. real-time demonstration of concept and analysis of

[Testing system design and analysis for the execution units of anti-thrombotic device].

PubMed

Li, Zhelong; Cui, Haipo; Shang, Kun; Liao, Yuehua; Zhou, Xun

2015-02-01

In an anti-thrombotic pressure circulatory device, relays and solenoid valves serve as core execution units. Thus the therapeutic efficacy and patient safety of the device will directly depend on their performance. A new type of testing system for relays and solenoid valves used in the anti-thrombotic device has been developed, which can test action response time and fatigue performance of relay and solenoid valve. PC, data acquisition card and test platform are used in this testing system based on human-computer interaction testing modules. The testing objectives are realized by using the virtual instrument technology, the high-speed data acquisition technology and reasonable software design. The two sets of the system made by relay and solenoid valve are tested. The results proved the universality and reliability of the testing system so that these relays and solenoid valves could be accurately used in the antithrombotic pressure circulatory equipment. The newly-developed testing system has a bright future in the aspects of promotion and application prospect.

Development and Testing of an Integrated Rotating Dynamometer Based on Fiber Bragg Grating for Four-Component Cutting Force Measurement

PubMed Central

Liu, Mingyao; Bing, Junjun; Xiao, Li; Yun, Kang; Wan, Liang

2018-01-01

Cutting force measurement is of great importance in machining processes. Hence, various methods of measuring the cutting force have been proposed by many researchers. In this work, a novel integrated rotating dynamometer based on fiber Bragg grating (FBG) was designed, constructed, and tested to measure four-component cutting force. The dynamometer consists of FBGs that are pasted on the newly designed elastic structure which is then mounted on the rotating spindle. The elastic structure is designed as two mutual-perpendicular semi-octagonal rings. The signals of the FBGs are transmitted to FBG interrogator via fiber optic rotary joints and optical fiber, and the wavelength values are displayed on a computer. In order to determine the static and dynamic characteristics, many tests have been done. The results show that it is suitable for measuring cutting force. PMID:29670062

Development and Testing of an Integrated Rotating Dynamometer Based on Fiber Bragg Grating for Four-Component Cutting Force Measurement.

PubMed

Liu, Mingyao; Bing, Junjun; Xiao, Li; Yun, Kang; Wan, Liang

2018-04-18

Cutting force measurement is of great importance in machining processes. Hence, various methods of measuring the cutting force have been proposed by many researchers. In this work, a novel integrated rotating dynamometer based on fiber Bragg grating (FBG) was designed, constructed, and tested to measure four-component cutting force. The dynamometer consists of FBGs that are pasted on the newly designed elastic structure which is then mounted on the rotating spindle. The elastic structure is designed as two mutual-perpendicular semi-octagonal rings. The signals of the FBGs are transmitted to FBG interrogator via fiber optic rotary joints and optical fiber, and the wavelength values are displayed on a computer. In order to determine the static and dynamic characteristics, many tests have been done. The results show that it is suitable for measuring cutting force.

Ergonomic design and evaluation of new surgical scissors.

PubMed

Shimomura, Yoshihiro; Shirakawa, Hironori; Sekine, Masashi; Katsuura, Tetsuo; Igarashi, Tatsuo

2015-01-01

The purpose of this study is to design a new surgical scissors handle and determine its effectiveness with various usability indices. A new scissors handle was designed that retains the professional grip but has the shapes of the eye rings modified to fit the thumb and ring finger and finger rests for the index and little finger. The newly designed scissors and traditional scissors were compared by electromyography, subjective evaluation and task performance in experiments using cutting and peeling tasks. The newly designed scissors reduced muscle load in both hand during cutting by the closing action, and reduced the muscle load in the left hand during peeling by the opening action through active use of the right hand. In evaluation by surgeons, task performance improved in addition to the decrease in muscle load. The newly designed scissors used in this study demonstrated high usability. A new scissors handle was designed that has the eye rings modified to fit the thumb and ring finger. The newly designed scissors reduced muscle load and enabled active use of the right hand. In evaluation by surgeons, task performance improved in addition to the decrease in muscle load.

Design of a 3T preamplifier which stability is insensitive to coil loading

NASA Astrophysics Data System (ADS)

Cao, Xueming; Fischer, Elmar; Korvink, Jan G.; Gruschke, Oliver; Hennig, Jürgen; Zaitsev, Maxim

2016-04-01

In MRI (magnetic resonance imaging), preamplifiers are needed to amplify signals obtained from MRI receiver coils. Under various loading conditions of the corresponding receiver coils, preamplifiers see different source impedance at their input and may become unstable. Therefore preamplifiers which stability is not sensitive to coil loading are desirable. In this article, a coil-loading-insensitive preamplifier for MRI is presented, derived from an unstable preamplifier. Different approaches to improve stability were used during this derivation. Since a very low noise factor is essential for MRI preamplifiers, noise contributions from passive components in the MRI preamplifier have to be considered during the stabilization process. As a result, the initially unstable preamplifier became stable with regard to coil loading, while other MRI requirements, as the extremely low noise factor, were still fulfilled. The newly designed preamplifier was manufactured, characterized and tested in the MRI spectrometer. Compared to a commercially available preamplifier, the newly designed preamplifier has similar imaging performance but other advantages like smaller size and better stability. Furthermore, presented stabilization approaches can be generalized to stabilize other unstable low-noise amplifiers.

Solid Hydrogen Experiments for Atomic Propellants: Particle Formation, Imaging, Observations, and Analyses

NASA Technical Reports Server (NTRS)

Palaszewski, Bryan

2005-01-01

This report presents particle formation observations and detailed analyses of the images from experiments that were conducted on the formation of solid hydrogen particles in liquid helium. Hydrogen was frozen into particles in liquid helium, and observed with a video camera. The solid hydrogen particle sizes and the total mass of hydrogen particles were estimated. These newly analyzed data are from the test series held on February 28, 2001. Particle sizes from previous testing in 1999 and the testing in 2001 were similar. Though the 2001 testing created similar particles sizes, many new particle formation phenomena were observed: microparticles and delayed particle formation. These experiment image analyses are some of the first steps toward visually characterizing these particles, and they allow designers to understand what issues must be addressed in atomic propellant feed system designs for future aerospace vehicles.

Design of an MR image processing module on an FPGA chip.

PubMed

Li, Limin; Wyrwicz, Alice M

2015-06-01

We describe the design and implementation of an image processing module on a single-chip Field-Programmable Gate Array (FPGA) for real-time image processing. We also demonstrate that through graphical coding the design work can be greatly simplified. The processing module is based on a 2D FFT core. Our design is distinguished from previously reported designs in two respects. No off-chip hardware resources are required, which increases portability of the core. Direct matrix transposition usually required for execution of 2D FFT is completely avoided using our newly-designed address generation unit, which saves considerable on-chip block RAMs and clock cycles. The image processing module was tested by reconstructing multi-slice MR images from both phantom and animal data. The tests on static data show that the processing module is capable of reconstructing 128×128 images at speed of 400 frames/second. The tests on simulated real-time streaming data demonstrate that the module works properly under the timing conditions necessary for MRI experiments. Copyright © 2015 Elsevier Inc. All rights reserved.

ARC-2010-AD10-0106-015

NASA Image and Video Library

2010-06-07

Stephen Beitashour, a professional soccer player from the San Jose Earthquakes, was asked to demonstrate kicking the ball for his student audience. With the increased globalization of soccer, more young people are playing the sport and developing motor skills to compete effectively. To enhance their skills, students in the United States and Canada recently were given the opportunity to discuss with a NASA scientist the aerodynamics of the newly designed soccer ball. To help student soccer players better understand the movement of the ball, NASA scientists at the Fluid Mechanics Laboratory at NASA’s Ames Research Center, Moffett Field, Calif., recently tested the performance of the Jabulani design, and compared it to the 2006 design. Included in this study was Rabi Mehta who had done previous tests on tennis and cricket balls in wind tunnels.

Practical application of power conditioning to electric propulsion for passenger vehicles

NASA Technical Reports Server (NTRS)

Demerdash, N. A.; Lee, F. C.; Nehl, T. W.; Overton, B. P.

1980-01-01

A functional model 15 HP, 120 volt, 4-pole, 7600 r.p.m. samarium-cobalt permanent magnet type brushless dc motor-transistorized power conditioner unit was designed, fabricated and tested for specific use in propulsion of electric passenger vehicles. This new brushless motor system, including its power conditioner package, has a number of important advantages over existing systems such as reduced weight and volume, higher reliability, and potential for improvements in efficiencies. These advantages are discussed in this paper in light of the substantial test data collected during experimentation with the newly developed conditioner motor propulsion system. Details of the power conditioner design philosophy and particulars are given in the paper. Also, described here are the low level electronic design and operation in relation to the remainder of the system.

Newly qualified doctors' views on the significance and accessibility of career advice during medical training in Saudi Arabia.

PubMed

Mehmood, Syed Imran; Norcini, John J; Borleffs, Jan C C

2013-01-01

Career advice is an important instrument to help students with the proper specialty selection. The study aims (1) to explore the views of newly graduated doctors in Saudi Arabia about their experience with the current status of career support system during medical training and (2) to identify cross-cultural similarities and differences. A cross-sectional design study was conducted using a questionnaire to elicit the responses of participants from newly qualified doctors concerning the availability and significance of career advice. SPSS (version 11.0; Chicago, IL) was used to analyze the data and statistical tests, such as chi-square and unpaired t tests, were used to analyze the observations. A response rate of 94.7% was obtained. Among this group, 102 were males and 78 were females. Only 53% did receive career advice. The majority of men felt that career advice during medical studies was inadequate, while women were less negative (69% versus 32%; p = 0.0001). Furthermore, men were more disappointed about the possibilities for career advice after graduating than women (34% versus 13%, p = 0.0001). The results show that only half of newly graduated doctors had received any career advice during medical training. As the health care system cannot afford the potential waste of time and resources for doctors, career guidance should begin in undergraduate training so that the process of thinking about their future career starts longtime before they make their career choice.

76 FR 33419 - Nationally Recognized Statistical Rating Organizations

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-08

... documentation of the internal control structure) or should the factors focus on the design (i.e., establishment... related to implementing them. a. Controls reasonably designed to ensure that a newly developed methodology... U.S.C. 78o-7(r)(1)(A). b. Controls reasonably designed to ensure that a newly developed methodology...

Human Factors Engineering and testing for a wearable, long duration ultrasound system self-applied by an end user.

PubMed

Taggart, Rebecca; Langer, Matthew D; Lewis, George K

2014-01-01

One of the major challenges in the design of a new class of medical device is ensuring that the device will have a safe and effective user interface for the intended users. Human Factors Engineering addresses these concerns through direct study of how a user interacts with newly designed devices with unique features. In this study, a novel long duration, low intensity therapeutic ultrasound device is tested by 20 end users representative of the intended user population. Over 90% of users were able to operate the device successfully. The therapeutic ultrasound device was found to be reasonably safe and effective for the intended users, uses, and use environments.

Experimental investigation of a newly designed supersonic wind tunnel

NASA Astrophysics Data System (ADS)

Wu, J.; Radespiel, R.

2015-06-01

The flow characteristics of the tandem nozzle supersonic wind tunnel at the Institute of Fluid Mechanics, Technische Universität Braunschweig, a are investigated. Conventional measurement techniques were utilized. The flow development is examined by pressure sensors installed at various streamwise positions. The temperature is measured in the storage tube and the settling chamber. The influence of flow treatment in the settling chamber on the flow quality is also studied. The flow quality of test section is evaluated by a 6-probe Pitot rake. The pressure fluctuations in the test section are studied by a sharp cone model. Eventually, good agreement between the measurements and numerical simulation of the tunnel design is achieved.

Advancement of Miniature Optic Gas Sensor (MOGS) Probe Technology

NASA Technical Reports Server (NTRS)

Chullen, Cinda

2015-01-01

Advancement of Miniature Optic Gas Sensor (MOGS) Probe Technology" project will investigate newly developed optic gas sensors delivered from a Small Business Innovative Research (SBIR) Phase II effort. A ventilation test rig will be designed and fabricated to test the sensors while integrated with a Suited Manikin Test Apparatus (SMTA). Once the sensors are integrated, a series of test points will be completed to verify that the sensors can withstand Advanced Suit Portable Life Support System (PLSS) environments and associated human metabolic profiles for changes in pressure and levels of Oxygen (ppO2), carbon dioxide (ppCO2), and humidity (ppH2O).

Sequence characterization of heat shock protein gene of Cyclospora cayetanensis isolates from Nepal, Mexico, and Peru.

PubMed

Sulaiman, Irshad M; Torres, Patricia; Simpson, Steven; Kerdahi, Khalil; Ortega, Ynes

2013-04-01

We have described the development of a 2-step nested PCR protocol based on the characterization of the 70-kDa heat shock protein (HSP70) gene for rapid detection of the human-pathogenic Cyclospora cayetanensis parasite. We tested and validated these newly designed primer sets by PCR amplification followed by nucleotide sequencing of PCR-amplified HSP70 fragments belonging to 16 human C. cayetanensis isolates from 3 different endemic regions that include Nepal, Mexico, and Peru. No genetic polymorphism was observed among the isolates at the characterized regions of the HSP70 locus. This newly developed HSP70 gene-based nested PCR protocol provides another useful genetic marker for the rapid detection of C. cayetanensis in the future.

Reliability, Maintainability, and Performance Issues in Hydraulic System Design

DTIC Science & Technology

1977-06-01

the piston and control valve, typically between 0.85 and 0.95 for an integrally mounted valve In a practical hardware installation, the actuator ...around the null position due to internal leakage through the piston seal and in the control valve. A newly installed CH-47 swashplate control actuator ...except when the pump is installed in the manu- facturer’s own test

High Efficiency, 100 mJ per pulse, Nd:YAG Oscillator Optimized for Space-Based Earth and Planetary Remote Sensing

NASA Technical Reports Server (NTRS)

Coyle, D. Barry; Stysley, Paul R.; Poulios, Demetrios; Fredrickson, Robert M.; Kay, Richard B.; Cory, Kenneth C.

2014-01-01

We report on a newly solid state laser transmitter, designed and packaged for Earth and planetary space-based remote sensing applications for high efficiency, low part count, high pulse energy scalability/stability, and long life. Finally, we have completed a long term operational test which surpassed 2 Billion pulses with no measured decay in pulse energy.

The Magic Shrinking Machine Revisited: The Presence of Props at Recall Facilitates Memory in 3-Year-Olds

ERIC Educational Resources Information Center

Dahl, Jonna J.; Kingo, Osman S.; Krøjgaard, Peter

2015-01-01

In a seminal study Simcock and Hayne (2002) showed that 3-year-olds were unable to use newly acquired words to describe a "magic" event experienced 6 or 12 months earlier. In the reference study the children's verbal recall was tested without props being present. Inspired by recent evidence, the original design was replicated, testing…

Education through Fiction: Acquiring Opinion-Forming Skills in the Context of Genomics

ERIC Educational Resources Information Center

Knippels, Marie-Christine P. J.; Severiens, Sabine E.; Klop, Tanja

2009-01-01

The present study examined the outcomes of a newly designed four-lesson science module on opinion-forming in the context of genomics in upper secondary education. The lesson plan aims to foster 16-year-old students' opinion-forming skills in the context of genomics and to test the effect of the use of fiction in the module. The basic hypothesis…

Alternative Assessments in Practice Data Base. Project 1.2: Technical Assistance on Assessment Issues. Annual Report of Communication, Training and Dissemination Activities.

ERIC Educational Resources Information Center

Center for Research on Evaluation, Standards, and Student Testing, Los Angeles, CA.

The Center for Research on Evaluation, Standards, and Student Testing (CRESST) has developed an Alternative Assessments in Practice Data Base to support technical assistance needs and to promote the exchange of new assessment ideas. The database is designed to provide easy access and retrieval of information about ongoing and newly developed…

The performance of components in the Skylab refrigeration system

NASA Technical Reports Server (NTRS)

Daniher, C. E., Jr.

1975-01-01

The on-orbit performance of the Skylab refrigeration system components is presented. Flight anomalies are analyzed and performance of the newly developed components is described. Nine months of orbit data proved the practicality of the leak-free coolant system design. Flight proven application of a thermal capacitor and development test results of the first all-mechanical, low temperature mixing valve represent a significant advance in single-phase, low temperature coolant loop design. System flight data suggest that additional instrumentation and fluid filters could have prevented system orbit performance anomalies.

Testing framework for embedded languages

NASA Astrophysics Data System (ADS)

Leskó, Dániel; Tejfel, Máté

2012-09-01

Embedding a new programming language into an existing one is a widely used technique, because it fastens the development process and gives a part of a language infrastructure for free (e.g. lexical, syntactical analyzers). In this paper we are presenting a new advantage of this development approach regarding to adding testing support for these new languages. Tool support for testing is a crucial point for a newly designed programming language. It could be done in the hard way by creating a testing tool from scratch, or we could try to reuse existing testing tools by extending them with an interface to our new language. The second approach requires less work, and also it fits very well for the embedded approach. The problem is that the creation of such interfaces is not straightforward at all, because the existing testing tools were mostly not designed to be extendable and to be able to deal with new languages. This paper presents an extendable and modular model of a testing framework, in which the most basic design decision was to keep the - previously mentioned - interface creation simple and straightforward. Other important aspects of our model are the test data generation, the oracle problem and the customizability of the whole testing phase.

Design and production of stopper made of concrete foam composite used for open channel conduit cover and parking bumper

NASA Astrophysics Data System (ADS)

Syam, Bustami; Sebayang, Alexander; Sebayang, Septian; Muttaqin, Maraghi; Darmadi, Harry; Basuki, WS; Sabri, M.; Abda, S.

2018-03-01

Open channel conduit is designed and produced with the aims to reduce excess water, whether from rain, seepage, or excess irrigation water in an area. It is also included in one of the important components of urban infrastructure in tackling the problem of flooding and waterlogging. On the roadway, e.g. housing complex the open channel conduits should function the same, however conduit covers are needed. The covers should be also designed to function as parking bumper. This paper discusses the design and production of the stoppers using our newly invented materials; the stoppers are structurally tested under static, dynamic, and bump test. Response of the conduit cover are found from structural analysis using finite element software ANSYS MECHANICAL version 17.5. Two types of stoppers are introduced: flat and curvy configuration. It was obtained that both types are suitable for open channel conduit cover and parking bumper.

Primary Stability Recognition of the Newly Designed Cementless Femoral Stem Using Digital Signal Processing

PubMed Central

Salleh, Sh-Hussain; Hamedi, Mahyar; Zulkifly, Ahmad Hafiz; Lee, Muhammad Hisyam; Mohd Noor, Alias; Harris, Arief Ruhullah A.; Abdul Majid, Norazman

2014-01-01

Stress shielding and micromotion are two major issues which determine the success of newly designed cementless femoral stems. The correlation of experimental validation with finite element analysis (FEA) is commonly used to evaluate the stress distribution and fixation stability of the stem within the femoral canal. This paper focused on the applications of feature extraction and pattern recognition using support vector machine (SVM) to determine the primary stability of the implant. We measured strain with triaxial rosette at the metaphyseal region and micromotion with linear variable direct transducer proximally and distally using composite femora. The root mean squares technique is used to feed the classifier which provides maximum likelihood estimation of amplitude, and radial basis function is used as the kernel parameter which mapped the datasets into separable hyperplanes. The results showed 100% pattern recognition accuracy using SVM for both strain and micromotion. This indicates that DSP could be applied in determining the femoral stem primary stability with high pattern recognition accuracy in biomechanical testing. PMID:24800230

Primary stability recognition of the newly designed cementless femoral stem using digital signal processing.

PubMed

Baharuddin, Mohd Yusof; Salleh, Sh-Hussain; Hamedi, Mahyar; Zulkifly, Ahmad Hafiz; Lee, Muhammad Hisyam; Mohd Noor, Alias; Harris, Arief Ruhullah A; Abdul Majid, Norazman

2014-01-01

Stress shielding and micromotion are two major issues which determine the success of newly designed cementless femoral stems. The correlation of experimental validation with finite element analysis (FEA) is commonly used to evaluate the stress distribution and fixation stability of the stem within the femoral canal. This paper focused on the applications of feature extraction and pattern recognition using support vector machine (SVM) to determine the primary stability of the implant. We measured strain with triaxial rosette at the metaphyseal region and micromotion with linear variable direct transducer proximally and distally using composite femora. The root mean squares technique is used to feed the classifier which provides maximum likelihood estimation of amplitude, and radial basis function is used as the kernel parameter which mapped the datasets into separable hyperplanes. The results showed 100% pattern recognition accuracy using SVM for both strain and micromotion. This indicates that DSP could be applied in determining the femoral stem primary stability with high pattern recognition accuracy in biomechanical testing.

Evaluation of six holmium:YAG optical fibers for ureteroscopy: What's new in 2009?

NASA Astrophysics Data System (ADS)

Knudsen, Bodo E.; Teichman, Joel M. H.

2010-02-01

The holmium:yttrium aluminum garnet (YAG) laser is the gold standard laser for intracorporeal lithotripsy.1 Optical fibers are utilized to transmit laser energy to the surface of a stone for fragmentation via a predominant photothermal mechanism.2 Previous work has demonstrated that performance characteristics of holmium:YAG optical fibers used for laser lithotripsy varies. Performance may difference not only between fibers made by different manufacturers but also between individual fibers produced by the same manufacturer.3,4 Fiber failure with bending, such as during lower pole ureterorenoscopy, can lead to catastrophic endoscope damage resulting in costly repair. Manufacturers continue to develop new holmium:YAG optical fibers. In this study we evaluate a series of newly commercially available fibers using a previously designed testing protocol. This study was designed to determine the performance and threshold for failure of six newly available holmium:YAG laser fibers from Cook Medical and Fibertech Gmbh. We hypothesize that fiber performance will continue to vary amongst different holmium:YAG optical fibers.

Toward earlier detection of choroidal neovascularization secondary to age-related macular degeneration: multicenter evaluation of a preferential hyperacuity perimeter designed as a home device.

PubMed

Loewenstein, Anat; Ferencz, Joseph R; Lang, Yaron; Yeshurun, Itamar; Pollack, Ayala; Siegal, Ruth; Lifshitz, Tova; Karp, Joseph; Roth, Daniel; Bronner, Guri; Brown, Justin; Mansour, Sam; Friedman, Scott; Michels, Mark; Johnston, Richards; Rapp, Moshe; Havilio, Moshe; Rafaeli, Omer; Manor, Yair

2010-01-01

The primary purpose of this study was to evaluate the ability of a home device preferential hyperacuity perimeter to discriminate between patients with choroidal neovascularization (CNV) and intermediate age-related macular degeneration (AMD), and the secondary purpose was to investigate the dependence of sensitivity on lesion characteristics. All participants were tested with the home device in an unsupervised mode. The first part of this work was retrospective using tests performed by patients with intermediate AMD and newly diagnosed CNV. In the second part, the classifier was prospectively challenged with tests performed by patients with intermediate AMD and newly diagnosed CNV. The dependence of sensitivity on lesion characteristics was estimated with tests performed by patients with CNV of both parts. In 66 eyes with CNV and 65 eyes with intermediate AMD, both sensitivity and specificity were 0.85. In the retrospective part (34 CNV and 43 intermediate AMD), sensitivity and specificity were 0.85 +/- 0.12 (95% confidence interval) and 0.84 +/- 0.11 (95% confidence interval), respectively. In the prospective part (32 CNV and 22 intermediate AMD), sensitivity and specificity were 0.84 +/- 0.13 (95% confidence interval) and 0.86 +/- 0.14 (95% confidence interval), respectively. Chi-square analysis showed no dependence of sensitivity on type (P = 0.44), location (P = 0.243), or size (P = 0.73) of the CNV lesions. A home device preferential hyperacuity perimeter has good sensitivity and specificity in discriminating between patients with newly diagnosed CNV and intermediate AMD. Sensitivity is not dependent on lesion characteristics.

A dynamic seating intervention for wheelchair seating discomfort.

PubMed

Crane, Barbara A; Holm, Margo B; Hobson, Douglas; Cooper, Rory A; Reed, Matthew P

2007-12-01

The objective of this study was to examine the effectiveness of a new user-adjustable wheelchair seating system designed to relieve discomfort for long-duration wheelchair users. This objective was carried out using the newly developed Tool for Assessing Wheelchair disComfort (TAWC) as the primary outcome measure. Two wheelchair users each tested two different designs and feedback from the wheelchair users regarding the first design was used to guide development of the second design. A single-subject research methodology was used, allowing long-duration (up to 2 wks per test) evaluation of the wheelchair seating systems and comparison of subject discomfort levels with those experienced during a baseline period using their own wheelchairs. The experimental wheelchair seating systems employed existing automotive seating with embedded pneumatic bladders that allowed adjustment of the seat and back-support characteristics. The test wheelchair also had tilt, recline, and elevating leg rests. The two subjects completed limited periods of testing with the first design, both finding poor results with either stable or increased levels of discomfort. Subject feedback was used to redesign the wheelchair seat. After redesign, both subjects tested the second design and found it substantially more comfortable. The selected research methodology was a very positive method for a progressive wheelchair seating design and the second design provided improved comfort for both users when compared with that experienced using their own wheelchairs and the first test wheelchair. Future research of this type of user-controlled technology is recommended.

Evaluation of new binders using newly developed fracture energy test.

DOT National Transportation Integrated Search

2013-07-01

This study evaluated a total of seven asphalt binders with various additives : using the newly developed binder fracture energy test. The researchers prepared and : tested PAV-aged and RTFO-plus-PAV-aged specimens. This study confirmed previous : res...

A Method for Evaluating the Efficacy of Antifouling Paints Using Mytilus galloprovincialis in the Laboratory in a Flow-Through System

PubMed Central

Satuito, Cyril Glenn Perez; Katsuyama, Ichiro; Ando, Hirotomo; Seki, Yasuyuki; Senda, Tetsuya

2016-01-01

A laboratory test with a flow-through system was designed and its applicability for testing antifouling paints of varying efficacies was investigated. Six different formulations of antifouling paints were prepared to have increasing contents (0 to 40 wt.%) of Cu2O, which is the most commonly used antifouling substance, and each formulation of paint was coated on just one surface of every test plate. The test plates were aged for 45 days by rotating them at a speed of 10 knots inside a cylinder drum. A behavioral test was then conducted using five mussels (Mytilus galloprovincialis) that were pasted onto the coated surface of each aged test plate. The number of the byssus threads produced by each mussel generally decreased with increasing Cu2O content of the paint. The newly designed method was considered valid owing to the high consistency of its results with observations from the field experiment. PMID:27959916

A serious game for improving the decision making skills and knowledge levels of Turkish football referees according to the laws of the game.

PubMed

Gulec, Ulas; Yilmaz, Murat

2016-01-01

Digital game-based learning environments provide emerging opportunities to overcome learning barriers by combining newly developed technologies and traditional game design. This study proposes a quantitative research approach supported by expert validation interviews to designing a game-based learning framework. The goal is to improve the learning experience and decision-making skills of soccer referees in Turkey. A serious game was developed and tested on a group of referees (N = 54). The assessment results of these referees were compared with two sample t-test and the Wilcoxon signed-ranked test for both the experimental group and the control group. The findings of the current study confirmed that a game-based learning environment has greater merit over the paper-based alternatives.

Design, testing, and economics of a 430 W sub p photovoltaic concentrator array for non grid-connected applications

NASA Astrophysics Data System (ADS)

Maish, A. B.; Rios, M., Jr.; Togami, H.

A stand-alone 430 W/sub p/ photovoltaic (PV) concentrating system for low power, non grid-connected applications has been designed, fabricated, and tested at Sandia National Laboratories. The array consists of four passively cooled Fresnel lens concentrating modules on a newly developed polar axis tracking structure. Two axis tracking is provided using a self powered clock drive unit mounted on a single post foundation. Test results of tracking accuracy, array output power, parasitic power, performance in winds and array reliability are discussed. using a range of estimated production costs for small production volumes, the life-cycle energy costs have been calculated and compared to the equivalent energy costs of a 3 kW diesel electric generator set and of an equivalent flat panel PV system.

A comparative study of antiplaque and antigingivitis effects of herbal mouthrinse containing tea tree oil, clove, and basil with commercially available essential oil mouthrinse

PubMed Central

Kothiwale, Shaila V.; Patwardhan, Vivek; Gandhi, Megha; Sohoni, Rahul; Kumar, Ajay

2014-01-01

Background: The relatively safe nature and cost-effectiveness of herbal extracts have led to a resurgent interest in their utility as therapeutic agents. Therefore, this prospective, double-blind, randomly controlled clinical trial was designed to compare the antiplaque and antigingivitis effects of newly formulated mouthrinse containing tea tree oil (TTO), clove, and basil with those of commercially available essential oil (EO) mouthrinse. Materials and Methods: Forty patients were selected for a 21-day study period and randomly divided into two groups. The test group patients were given newly formulated herbal mouthrinse and the control group patients were given commercially available EO mouthrinse. The Plaque Index (PI), Gingival Index (GI), and Papillary Marginal Attachment (PMA) Index were recorded at baseline, 14 days, and 21 days. The microbial colony forming units (CFU) were assessed at baseline and 21 days. Results: Test group patients using herbal mouthrinse showed significant improvement in GI (0.16), PI (0.57), and PMA (0.02) scores. These improvements were comparable to those achieved with commercially available EO mouthrinse. However, the aerobic and anaerobic CFU of microbiota were reduced with the herbal mouthrinse (P = 0.0000). Conclusion: The newly formulated herbal mouthrinse and commercially available mouthrinse were beneficial clinically as antiplaque and antigingivitis agents. Newly formulated mouthrinses showed significant reduction in microbial CFU at 21 days. So, our findings support the regular use of herbal mouthrinse as an antiplaque, antigingivitis, and antimicrobial rinse for better efficacy. PMID:25024544

DNA from BK Virus and JC Virus and from KI, WU, and MC Polyomaviruses as Well as from Simian Virus 40 Is Not Detected in Non-UV-Light-Associated Primary Malignant Melanomas of Mucous Membranes ▿

PubMed Central

Giraud, Géraldine; Ramqvist, Torbjörn; Ragnarsson-Olding, Boel; Dalianis, Tina

2008-01-01

The single most important causative factor for malignant melanomas of the skin is UV radiation. However, this is not true for melanomas on body surfaces sheltered from the sun; thus, it is important to seek new causative factors of melanoma genesis. Human papillomaviruses and gammaherpesviruses are associated with human skin cancer; for example, human papillomavirus types 5 and 8 are associated with epidermodysplasia verruciformis, and human herpesvirus 8 is associated with Kaposi's sarcoma. Recently, a newly described human polyomavirus, Merkel cell polyomavirus (MCPyV), has been associated with Merkel cell carcinoma, an unusual form of neurotropic skin cancer. Moreover, melanocytes are of neuroepithelial origin. This background impelled us to investigate if human polyomavirus DNA could play a role in the development of extracutaneous melanomas. Sixty-four extracutaneous melanomas were initially collected and dissected. Of these, 38 could be successfully used for further testing for the presence of the five human polyomaviruses known so far—BK virus (BKV), JC virus (JCV), KI polyomavirus (KIPyV), WU polyomavirus (WUPyV), and MCPyV—and of simian virus 40 (SV40). No polyomavirus DNA could be detected in any of the samples tested by use of a nested PCR detecting BKV, JCV, and SV40; a newly designed PCR detecting KIPyV and WUPyV; or a newly designed PCR for MCPyV. We conclude that since no human polyomavirus DNA was detected in primary malignant melanomas on non-sun-exposed body surfaces, these polyomaviruses presumably are not major factors for the development of extracutaneous melanomas. PMID:18768658

Development and implementation of a propeller test capability for GL-10 "Greased Lightning" propeller design

NASA Astrophysics Data System (ADS)

Duvall, Brian Edward

Interest in small unmanned aerial vehicles has increased dramatically in recent years. Hybrid vehicles which allow forward flight as a fixed wing aircraft and a true vertical landing capability have always had applications. Management of the available energy and noise associated with electric propeller propulsion systems presents many challenges. NASA Langley has developed the Greased Lightning 10 (GL-10) vertical takeoff, unmanned aerial vehicle with ten individual motors and propellers. All are used for propulsion during takeoff and contribute to acoustic noise pollution which is an identified nuisance to the surrounding users. A propeller test capability was developed to gain an understanding of how the noise can be reduced while meeting minimum thrust requirements. The designed propeller test stand allowed for various commercially available propellers to be tested for potential direct replacement of the current GL-10 propellers and also supported testing of a newly designed propeller provided by the Georgia Institute of Technology. Results from the test program provided insight as to which factors affect the noise as well as performance characteristics. The outcome of the research effort showed that the current GL-10 propeller still represents the best choice of all the candidate propellers tested.

O-5S quantitative real-time PCR: a new diagnostic tool for laboratory confirmation of human onchocerciasis.

PubMed

Mekonnen, Solomon A; Beissner, Marcus; Saar, Malkin; Ali, Solomon; Zeynudin, Ahmed; Tesfaye, Kassahun; Adbaru, Mulatu G; Battke, Florian; Poppert, Sven; Hoelscher, Michael; Löscher, Thomas; Bretzel, Gisela; Herbinger, Karl-Heinz

2017-10-02

Onchocerciasis is a parasitic disease caused by the filarial nematode Onchocerca volvulus. In endemic areas, the diagnosis is commonly confirmed by microscopic examination of skin snip samples, though this technique is considered to have low sensitivity. The available melting-curve based quantitative real-time PCR (qPCR) using degenerated primers targeting the O-150 repeat of O. volvulus was considered insufficient for confirming the individual diagnosis, especially in elimination studies. This study aimed to improve detection of O. volvulus DNA in clinical samples through the development of a highly sensitive qPCR assay. A novel hydrolysis probe based qPCR assay was designed targeting the specific sequence of the O. volvulus O-5S rRNA gene. A total of 200 clinically suspected onchocerciasis cases were included from Goma district in South-west Ethiopia, from October 2012 through May 2013. Skin snip samples were collected and subjected to microscopy, O-150 qPCR, and the novel O-5S qPCR. Among the 200 individuals, 133 patients tested positive (positivity rate of 66.5%) and 67 negative by O-5S qPCR, 74 tested positive by microscopy (37.0%) and 78 tested positive by O-150 qPCR (39.0%). Among the 133 O-5S qPCR positive individuals, microscopy and O-150 qPCR detected 55.6 and 59.4% patients, respectively, implying a higher sensitivity of O-5S qPCR than microscopy and O-150 qPCR. None of the 67 individuals who tested negative by O-5S qPCR tested positive by microscopy or O-150 qPCR, implying 100% specificity of the newly designed O-5S qPCR assay. The novel O-5S qPCR assay is more sensitive than both microscopic examination and the existing O-150 qPCR for the detection of O. volvulus from skin snip samples. The newly designed assay is an important step towards appropriate individual diagnosis and control of onchocerciasis.

CDC-funded HIV testing, HIV positivity, and linkage to HIV medical care in non-health care settings among young men who have sex with men (YMSM) in the United States.

PubMed

Seth, Puja; Walker, Tanja; Figueroa, Argelia

2017-07-01

In the United States, HIV infection disproportionately affects young gay, bisexual, and other men who have sex with men, aged 13-24 years (collectively referred to as YMSM), specifically black YMSM. Knowledge of HIV status is the first step for timely and essential prevention and treatment services. Because YMSM are disproportionately affected by HIV, the number of CDC-funded HIV testing events, overall and newly diagnosed HIV positivity, and linkage to HIV medical care among YMSM in non-health care settings were examined from 61 health department jurisdictions. Differences by age and race/ethnicity were analyzed. Additionally, trends in number of HIV testing events and newly diagnosed HIV positivity were examined from 2011 to 2015. In 2015, 42,184 testing events were conducted among YMSM in non-health care settings; this represents only 6% of tests in non-health care settings. Overall and newly diagnosed HIV positivity was 2.8% and 2.1%, respectively, with black/African-American YMSM being disproportionately affected (5.6% for overall; 4% for newly diagnosed); 71% of YMSM were linked within 90 days. The newly diagnosed HIV positivity among YMSM decreased from 2.8% in 2011 to 2.4% in 2015, and the number of newly diagnosed YMSM also decreased. Further targeted testing efforts among YMSM are needed to identify undiagnosed YMSM, specifically black YMSM.

Space Radiation Shielding Studies for Astronaut and Electronic Component Risk Assessment

NASA Technical Reports Server (NTRS)

Fuchs, Jordan Robert

2010-01-01

The dosimetry component of the Center for Radiation Engineering and Science for Space Exploration (CRESSE) will design, develop and characterize the response of a suite of radiation detectors and supporting instrumentation and electronics with three primary goals that will: (1) Use established space radiation detection systems to characterize the primary and secondary radiation fields existing in the experimental test-bed zones during exposures at particle accelerator facilities. (2) Characterize the responses of newly developed space radiation detection systems in the experimental test-bed zones during exposures at particle accelerator facilities, and (3) Provide CRESSE collaborators with detailed dosimetry information in experimental test-bed zones.

Arc-Heater Facility for Hot Hydrogen Exposure of Nuclear Thermal Rocket Materials

NASA Technical Reports Server (NTRS)

Litchford, Ron J.; Foote, John P.; Wang,Ten-See; Hickman, Robert; Panda, Binayak; Dobson, Chris; Osborne, Robin; Clifton, Scooter

2006-01-01

A hyper-thermal environment simulator is described for hot hydrogen exposure of nuclear thermal rocket material specimens and component development. This newly established testing capability uses a high-power, multi-gas, segmented arc-heater to produce high-temperature pressurized hydrogen flows representative of practical reactor core environments and is intended to serve. as a low cost test facility for the purpose of investigating and characterizing candidate fueUstructura1 materials and improving associated processing/fabrication techniques. Design and development efforts are thoroughly summarized, including thermal hydraulics analysis and simulation results, and facility operating characteristics are reported, as determined from a series of baseline performance mapping tests.

Transition Fracture Toughness Characterization of Eurofer 97 Steel using Pre-Cracked Miniature Multi-notch Bend Bar Specimens

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Xiang; Sokolov, Mikhail A.; Linton, Kory D.

In this report, we present the feasibility study of using pre-cracked miniature multi-notch bend bar specimens (M4CVN) with a dimension of 45mm (length) x 3.3mm (width) x 1.65mm (thickness) to characterize the transition fracture toughness of Eurofer97 based on the ASTM E1921 Master Curve method. From literature survey results, we did not find any obvious specimen size effects on the measured fracture toughness of unirradiated Eurofer97. Nonetheless, in order to exclude the specimen size effect on the measured fracture toughness of neutron irradiated Eurofer97, comparison of results obtained from larger size specimens with those from smaller size specimens after neutronmore » irradiation is necessary, which is not practical and can be formidably expensive. However, limited literature results indicate that the transition fracture toughness of Eurofer97 obtained from different specimen sizes and geometries followed the similar irradiation embrittlement trend. We then described the newly designed experimental setup to be used for testing neutron irradiated Eurofer97 pre-cracked M4CVN bend bars in the hot cell. We recently used the same setup for testing neutron irradiated F82H pre-cracked miniature multi-notch bend bars with great success. Considering the similarity in materials, specimen types, and the nature of tests between Eurofer97 and F82H, we believe the newly designed experimental setup can be used successfully in fracture toughness testing of Eurofer97 pre-cracked M4CVN specimens.« less

Safer Aviation Materials Tested

NASA Technical Reports Server (NTRS)

Palaszewski, Bryan A.

2001-01-01

A series of thermally stable polymer samples were tested. These materials are called low heat release materials and are designed for aircraft interior decorative materials. The materials are designed to give off a minimum amount of noxious gases when heated, which increases the possibility that people can escape from a burning aircraft. New cabin materials have suitably low heat release so that fire does not spread, toxic chemicals are not given off, and the fire-emergency escape time for crew and passengers is lengthened. These low heat-release materials have a variety of advantages and applications: interiors for ground-based facilities, interiors of space vehicles, and many commercial fire-protection environments. A microscale combustion calorimeter at the Federal Aviation Administration's (FAA) Technical Center tested NASA Langley Research Center materials samples. The calorimeter is shown. A sharp, quantitative, and reproducible heat-release-rate peak is obtained in the microscale heat-release-rate test. The newly tested NASA materials significantly reduced the heat release capacity and total heat release. The thermal stability and flammability behavior of the samples was very good. The new materials demonstrated a factor of 4 reduction in total heat release over ULTEM (a currently used material). This information is provided in the following barchart. In other tests, the materials showed greater than a factor 9 reduction in heat-release capacity over ULTEM. The newly tested materials were developed for low dielectric constant, low color, and good solubility. A scale up of the material samples is needed to determine the repeatability of the performance in larger samples. Larger panels composed of the best candidate materials will be tested in a larger scale FAA Technical Center fire facility. The NASA Glenn Research Center, Langley (Jeff Hinkley), and the FAA Technical Center (Richard Lyon) cooperatively tested these materials for the Accident Mitigation aspects of Fire Prevention under NASA's Aviation Safety Program.

Single phase space laundry development

NASA Technical Reports Server (NTRS)

Colombo, Gerald V.; Putnam, David F.; Lunsford, Teddie D.; Streech, Neil D.; Wheeler, Richard R., Jr.; Reimers, Harold

1993-01-01

This paper describes a newly designed, 2.7 Kg (6 pound) capacity, laundry machine called the Single Phase Laundry (SPSL). The machine was designed to wash and dry crew clothing in a micro-gravity environment. A prototype unit was fabricated for NASA-JSC under a Small Business Innovated Research (SBIR) contract extending from September 1990 to January 1993. The unit employs liquid jet agitation, microwave vacuum drying, and air jet tumbling, which was perfected by KC-135 zero-g flight testing. Operation is completely automated except for loading and unloading clothes. The unit uses about 20 percent less power than a conventional household appliance.

Analysis and Experimental Investigation of Optimum Design of Thermoelectric Cooling/Heating System for Car Seat Climate Control (CSCC)

NASA Astrophysics Data System (ADS)

Elarusi, Abdulmunaem; Attar, Alaa; Lee, HoSung

2018-02-01

The optimum design of a thermoelectric system for application in car seat climate control has been modeled and its performance evaluated experimentally. The optimum design of the thermoelectric device combining two heat exchangers was obtained by using a newly developed optimization method based on the dimensional technique. Based on the analytical optimum design results, commercial thermoelectric cooler and heat sinks were selected to design and construct the climate control heat pump. This work focuses on testing the system performance in both cooling and heating modes to ensure accurate analytical modeling. Although the analytical performance was calculated using the simple ideal thermoelectric equations with effective thermoelectric material properties, it showed very good agreement with experiment for most operating conditions.

Development of a Coaxial Pulse Tube Cryocooler for 77 K Cooling

NASA Astrophysics Data System (ADS)

Olson, J. R.; Moore, M.; Evtimov, B.; Jensen, J.; Nast, T. C.

2006-04-01

Lockheed Martin's Advanced Technology Center has developed a compact coaxial pulse tube cryocooler for avionics applications. The cooler was designed to deliver in excess of 1W cooling at 77K with a heat rejection temperature of 70°C, and to cool down from ambient temperature in a very short period of time. The cryocooler utilizes our MINI compressor, developed for NASA-GSFC, coupled with a newly-designed coaxial pulse tube designed to approximate the Standard Advanced Dewar Assembly (SADA II) packaging envelope. The cryocooler mass is 1.25 kg. Test data show excellent performance, with cooldown times of less than 6 minutes (coldhead only, with no additional thermal mass attached to the coldhead). Performance data will be shown for a variety of operating conditions. A discussion of low cost pulse tube cryocoolers will also be presented. This cryocooler was developed and tested with Lockheed Martin IRAD funding.

Passive isolation/damping system for the Hubble space telescope reaction wheels

NASA Technical Reports Server (NTRS)

Hasha, Martin D.

1987-01-01

NASA's Hubble Space Telescope contain large, diffraction limited optics with extraordinary resolution and performance for surpassing existing observatories. The need to reduce structural borne vibration and resultant optical jitter from critical Pointing Control System components, Reaction Wheels, prompted the feasibility investigation and eventual development of a passive isolation system. Alternative design concepts considered were required to meet a host of stringent specifications and pass rigid tests to be successfully verified and integrated into the already built flight vehicle. The final design employs multiple arrays of fluid damped springs that attenuate over a wide spectrum, while confining newly introduced resonances to benign regions of vehicle dynamic response. Overall jitter improvement of roughly a factor of 2 to 3 is attained with this system. The basis, evolution, and performance of the isolation system, specifically discussing design concepts considered, optimization studies, development lessons learned, innovative features, and analytical and ground test verified results are presented.

Validity of a Newly-Designed Rectilinear Stepping Ergometer Submaximal Exercise Test to Assess Cardiorespiratory Fitness

PubMed Central

Zhang, Rubin; Zhan, Likui; Sun, Shaoming; Peng, Wei; Sun, Yining

2017-01-01

The maximum oxygen uptake (V̇O2 max), determined from graded maximal or submaximal exercise tests, is used to classify the cardiorespiratory fitness level of individuals. The purpose of this study was to examine the validity and reliability of the YMCA submaximal exercise test protocol performed on a newly-designed rectilinear stepping ergometer (RSE) that used up and down reciprocating vertical motion in place of conventional circular motion and giving precise measurement of workload, to determine V̇O2 max in young healthy male adults. Thirty-two young healthy male adults (32 males; age range: 20-35 years; height: 1.75 ± 0.05 m; weight: 67.5 ± 8.6 kg) firstly participated in a maximal-effort graded exercise test using a cycle ergometer (CE) to directly obtain measured V̇O2 max. Subjects then completed the progressive multistage test on the RSE beginning at 50W and including additional stages of 70, 90, 110, 130, and 150W, and the RSE YMCA submaximal test consisting of a workload increase every 3 minutes until the termination criterion was reached. A metabolic equation was derived from the RSE multistage exercise test to predict oxygen consumption (V̇O2) from power output (W) during the submaximal exercise test (V̇O2 (mL·min-1 )=12.4 ×W(watts)+3.5 mL·kg-1·min-1×M+160mL·min-1, R2= 0.91, standard error of the estimate (SEE) = 134.8mL·min-1). A high correlation was observed between the RSE YMCA estimated V̇O2 max and the CE measured V̇O2 max (r=0.87). The mean difference between estimated and measured V̇O2 max was 2.5 mL·kg-1·min-1, with an SEE of 3.55 mL·kg-1·min-1. The data suggest that the RSE YMCA submaximal exercise test is valid for predicting V̇O2 max in young healthy male adults. The findings show that the rectilinear stepping exercise is an effective submaximal exercise for predicting V̇O2 max. The newly-designed RSE may be potentially further developed as an alternative ergometer for assessing cardiorespiratory fitness and the promotion of personalized health interventions for health care professionals. Key points The rectilinear stepping exercise is a simple modality of exercise, which requires only up and down movements of the legs. It overcomes the mechanical dead centers of circular motion and is mechanically efficient. It is potentially applicable to a large group of populations. The RSE gives an accurate measurement of power output and ensures a constant power output independent of stepping cadence. The RSE submaximal exercise test is valid and feasible for estimating V̇O2 max in young healthy male adults compared with the CE maximal exercise test. The rectilinear stepping exercise is an effective submaximal exercise mode for predicting V̇O2 max. The RSE designed for this study may be potentially developed as a new and alternative ergometer to assess cardiorespiratory fitness and could be used in the future by healthcare professionals to promote personalized health interventions. PMID:28912653

Deploy Nalu/Kokkos algorithmic infrastructure with performance benchmarking.

DOE Office of Scientific and Technical Information (OSTI.GOV)

Domino, Stefan P.; Ananthan, Shreyas; Knaus, Robert C.

The former Nalu interior heterogeneous algorithm design, which was originally designed to manage matrix assembly operations over all elemental topology types, has been modified to operate over homogeneous collections of mesh entities. This newly templated kernel design allows for removal of workset variable resize operations that were formerly required at each loop over a Sierra ToolKit (STK) bucket (nominally, 512 entities in size). Extensive usage of the Standard Template Library (STL) std::vector has been removed in favor of intrinsic Kokkos memory views. In this milestone effort, the transition to Kokkos as the underlying infrastructure to support performance and portability onmore » many-core architectures has been deployed for key matrix algorithmic kernels. A unit-test driven design effort has developed a homogeneous entity algorithm that employs a team-based thread parallelism construct. The STK Single Instruction Multiple Data (SIMD) infrastructure is used to interleave data for improved vectorization. The collective algorithm design, which allows for concurrent threading and SIMD management, has been deployed for the core low-Mach element- based algorithm. Several tests to ascertain SIMD performance on Intel KNL and Haswell architectures have been carried out. The performance test matrix includes evaluation of both low- and higher-order methods. The higher-order low-Mach methodology builds on polynomial promotion of the core low-order control volume nite element method (CVFEM). Performance testing of the Kokkos-view/SIMD design indicates low-order matrix assembly kernel speed-up ranging between two and four times depending on mesh loading and node count. Better speedups are observed for higher-order meshes (currently only P=2 has been tested) especially on KNL. The increased workload per element on higher-order meshes bene ts from the wide SIMD width on KNL machines. Combining multiple threads with SIMD on KNL achieves a 4.6x speedup over the baseline, with assembly timings faster than that observed on Haswell architecture. The computational workload of higher-order meshes, therefore, seems ideally suited for the many-core architecture and justi es further exploration of higher-order on NGP platforms. A Trilinos/Tpetra-based multi-threaded GMRES preconditioned by symmetric Gauss Seidel (SGS) represents the core solver infrastructure for the low-Mach advection/diffusion implicit solves. The threaded solver stack has been tested on small problems on NREL's Peregrine system using the newly developed and deployed Kokkos-view/SIMD kernels. fforts are underway to deploy the Tpetra-based solver stack on NERSC Cori system to benchmark its performance at scale on KNL machines.« less

A Goniometry Paradigm Shift to Measure Burn Scar Contracture in Burn Patients

DTIC Science & Technology

2017-10-01

test more extensively a recently designed Revised Goniometry (RG) method and compare it to Standard Goniometry (SG)used to measure burn scar...joint angle measurements willbe found between SG techniques compared to RG techniques which incorporate CKM and CFU principles. Specific Aim 1: To... compare the average reduction in joint range of motion measured with the standard GM measurements to a newly conceived set of revised GM measurements in

KSC-04PD-2679

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. The newly shod Crawler Transporter is checked out before beginning a road test. The Crawler Transporter that will move Space Shuttle Discovery to the launch pad for Return to Flight is taking its first road test following the replacement of all its shoes. The crawlers have 456 shoes, 57 per belt (8 belts in all). Each shoe weighs 2,200 pounds. Cracks appeared in the shoes in recent years, spurring a need for replacement. The new manufacturer, in Duluth, Minn., has improved the design for a safe Return to Flight and use through the balance of the Space Shuttle Program.

KSC-04PD-2682

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. The newly shod Crawler Transporter moves forward slowly as it begins its road test. The Crawler Transporter that will move Space Shuttle Discovery to the launch pad for Return to Flight is taking its first road test following the replacement of all its shoes. The crawlers have 456 shoes, 57 per belt (8 belts in all). Each shoe weighs 2,200 pounds. Cracks appeared in the shoes in recent years, spurring a need for replacement. The new manufacturer, in Duluth, Minn., has improved the design for a safe Return to Flight and use through the balance of the Space Shuttle Program.

KSC-04PD-2680

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. The newly shod Crawler Transporter is checked out before beginning its road test. The Crawler Transporter that will move Space Shuttle Discovery to the launch pad for Return to Flight is taking its first road test following the replacement of all its shoes. The crawlers have 456 shoes, 57 per belt (8 belts in all). Each shoe weighs 2,200 pounds. Cracks appeared in the shoes in recent years, spurring a need for replacement. The new manufacturer, in Duluth, Minn., has improved the design for a safe Return to Flight and use through the balance of the Space Shuttle Program.

KSC-04PD-2681

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. The newly shod Crawler Transporter is ready for its road test. The Crawler Transporter that will move Space Shuttle Discovery to the launch pad for Return to Flight is taking its first road test following the replacement of all its shoes. The crawlers have 456 shoes, 57 per belt (8 belts in all). Each shoe weighs 2,200 pounds. Cracks appeared in the shoes in recent years, spurring a need for replacement. The new manufacturer, in Duluth, Minn., has improved the design for a safe Return to Flight and use through the balance of the Space Shuttle Program.

KSC-04PD-2678

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. The newly shod Crawler Transporter is ready for a road test. The Crawler Transporter that will move Space Shuttle Discovery to the launch pad for Return to Flight is taking its first road test following the replacement of all its shoes. The crawlers have 456 shoes, 57 per belt (8 belts in all). Each shoe weighs 2,200 pounds. Cracks appeared in the shoes in recent years, spurring a need for replacement. The new manufacturer, in Duluth, Minn., has improved the design for a safe Return to Flight and use through the balance of the Space Shuttle Program.

STS-26 MS Nelson during Crew escape system (CES) testing in JSC WETF Bldg 29

NASA Image and Video Library

1988-07-08

S88-42409 (20 July 1988) --- STS-26 Discovery, Orbiter Vehicle (OV) 103, Mission Specialist (MS) George D. Nelson participates in crew escape system (CES) testing in JSC Weightless Environment Training Facility (WETF) Bldg 29. Nelson, wearing the newly designed (navy blue) launch and entry suit (LES), floats in WETF pool with the aid of an underarm flotation device (modern version of Mas West floats). He awaits the assistance of SCUBA-equipped divers during a simulation of escape and rescue operations utilizing a new CES pole for emergency exit from the Space Shuttle.

Drop-Weight Impact Test on U-Shape Concrete Specimens with Statistical and Regression Analyses

PubMed Central

Zhu, Xue-Chao; Zhu, Han; Li, Hao-Ran

2015-01-01

According to the principle and method of drop-weight impact test, the impact resistance of concrete was measured using self-designed U-shape specimens and a newly designed drop-weight impact test apparatus. A series of drop-weight impact tests were carried out with four different masses of drop hammers (0.875, 0.8, 0.675 and 0.5 kg). The test results show that the impact resistance results fail to follow a normal distribution. As expected, U-shaped specimens can predetermine the location of the cracks very well. It is also easy to record the cracks propagation during the test. The maximum of coefficient of variation in this study is 31.2%; it is lower than the values obtained from the American Concrete Institute (ACI) impact tests in the literature. By regression analysis, the linear relationship between the first-crack and ultimate failure impact resistance is good. It can suggested that a minimum number of specimens is required to reliably measure the properties of the material based on the observed levels of variation. PMID:28793540

Improvements in Limb Kinetic Apraxia by Repetition of a Newly Designed Facilitation Exercise in a Patient with Corticobasal Degeneration

ERIC Educational Resources Information Center

Kawahira, Kazumi; Noma, Tomokazu; Iiyama, Junichi; Etoh, Seiji; Ogata, Atsuko; Shimodozono, Megumi

2009-01-01

Corticobasal degeneration is a progressive neurological disorder characterized by a combination of parkinsonism and cortical dysfunction such as limb kinetic apraxia, alien limb phenomenon, and dementia. To study the effect of repetitive facilitation exercise (RFE) in a patient with corticobasal degeneration, we used a newly designed facilitation…

NURSING 911: an orientation program to improve retention of online RN-BSN students.

PubMed

Gilmore, Melanie; Lyons, Evadna M

2012-01-01

This article describes the implementation and evaluation of an eight-hour, comprehensive, face-to-face orientation program designed to improve student retention in a newly developed online RN to BSN program. A total of 179 newly enrolled RN to BSN students participated in the orientation program and evaluated the process. Student attrition decreased from 20 percent to less than 1 percent after the orientation program was extended and improved to include a technology assessment and an online practice course. A quality online program requires a well-designed orientation that includes technological assessments and hands-on, active participation by the learner. The newly improved and designed course has become effective in student retention and transition into the online learning environment.

A study on the flow characteristics of a direct drive turbine for energy conversion generation by experiment and CFD

NASA Astrophysics Data System (ADS)

Cho, Y. J.; Zullah, M. A.; Faizal, M.; Choi, Y. D.; Lee, Y. H.

2012-11-01

A variety of technologies has been proposed to capture the energy from waves. Some of the more promising designs are undergoing demonstration testing at commercial scales. Due to the complexity of most offshore wave energy devices and their motion response in different sea states, physical tank tests are common practice for WEC design. Full scale tests are also necessary, but are expensive and only considered once the design has been optimized. Computational Fluid Dynamics (CFD) is now recognized as an important complement to traditional physical testing techniques in offshore engineering. Once properly calibrated and validated to the problem, CFD offers a high density of test data and results in a reasonable timescale to assist with design changes and improvements to the device. The purpose of this study is to investigate the performance of a newly developed direct drive hydro turbine (DDT), which will be built in a caisson for extraction of wave energy. Experiments and CFD analysis are conducted to clarify the turbine performance and internal flow characteristics. The results show that commercial CFD code can be applied successfully to the simulation of the wave motion in the water tank. The performance of the turbine for wave energy converter is studied continuously for a ongoing project.

The Spelling Project. Technical Report 1992-2.

ERIC Educational Resources Information Center

Green, Kathy E.; Schroeder, David H.

Results of an analysis of a newly developed spelling test and several related measures are reported. Information about the reliability of a newly developed spelling test; its distribution of scores; its relationship with the standard battery of aptitude tests of the Johnson O'Connor Research Foundation; and its relationships with sex, age,…

Center for Epidemiologic Studies Depression Scale for Children: psychometric testing of the Chinese version.

PubMed

Li, Ho Cheung William; Chung, Oi Kwan Joyce; Ho, Ka Yan

2010-11-01

This paper is a report of psychometric testing of the Chinese version of the Center for Epidemiologic Studies Depression Scale for Children. The availability of a valid and reliable instrument that accurately detects depressive symptoms in children is crucial before any psychological intervention can be appropriately planned and evaluated. There is no such an instrument for Chinese children. A test-retest, within-subjects design was used. A total of 313 primary school students between the ages of 8 and 12 years were invited to participate in the study in 2009. Participants were asked to respond to the Chinese version of the Center for Epidemiologic Studies Depression Scale for Children, short form of the State Anxiety Scale for Children and Rosenberg's Self-Esteem Scale. The internal consistency, content validity and construct validity and test-retest reliability of the Chinese version of the Center for Epidemiologic Studies Depression Scale for Children were assessed. The newly-translated scale demonstrated adequate internal consistency, good content validity and appropriate convergent and discriminant validity. Confirmatory factor analysis added further evidence of the construct validity of the scale. Results suggest that the newly-translated scale can be used as a self-report assessment tool in detecting depressive symptoms of Chinese children aged between 8 and 12 years. © 2010 Blackwell Publishing Ltd.

Herth hope index: psychometric testing of the Chinese version.

PubMed

Chan, Keung Sum; Li, Ho Cheung William; Chan, Sally Wai-Chi; Lopez, Violeta

2012-09-01

This article is a report on psychometric testing of the Chinese version of the herth hope index. The availability of a valid and reliable instrument that accurately measures the level of hope in patients with heart failure is crucial before any hope-enhancing interventions can be appropriately planned and evaluated. There is no such instrument for Chinese people. A test-retest, within-subjects design was used. A purposive sample of 120 Hong Kong Chinese patients with heart failure between the ages of 60 and 80 years admitted to two medical wards was recruited during an 8-month period in 2009. Participants were asked to respond to the Chinese version of the herth hope index, Hamilton depression rating scale and Rosenberg's self-esteem scale. The internal consistency, content validity and construct validity and test-retest reliability of the Chinese version of the herth hope index were assessed. The newly translated scale demonstrated adequate internal consistency, good content validity and appropriate convergent and discriminant validity. Confirmatory factor analysis added further evidence of the construct validity of the scale. Results suggest that the newly translated scale can be used as a self-report assessment tool in assessing the level of hope in Hong Kong Chinese patients with heart failure. © 2011 Blackwell Publishing Ltd.

X-38 Landing Gear Skid Test Report

NASA Technical Reports Server (NTRS)

Gafka, George K.; Daugherty, Robert H.

2000-01-01

NASA incorporates skid-equipped landing gear on its series of X-38 flight test vehicles. The X-38 test program is the proving ground for the Crew Return Vehicle (CRV) a gliding parafoil-equipped vehicle designed to land at relatively low speeds. The skid-equipped landing gear is designed to attenuate the vertical landing energy of the vehicle at touchdown using crushable materials within the struts themselves. The vehicle then slides out as the vehicle horizontal energy is dissipated through the skids. A series of tests was conducted at Edwards Airforce Base (EAFB) in an attempt to quantify the drag force produced while "dragging" various X-38 landing gear skids across lakebed regions of varying surface properties. These data were then used to calculate coefficients of friction for each condition. Coefficient of friction information is critical for landing analyses as well as for landing gear load and interface load analysis. The skid specimens included full- and sub-scale V201 (space test vehicle) nose and main gear designs, a V131/V 132 (atmospheric flight test vehicles) main gear skid (actual flight hardware), and a newly modified, full-scale V201 nose -ear skid with substantially increased edge curvature as compared to its original design. Results of the testing are discussed along with comments on the relative importance of various parameters that influence skid stability and other dynamic behavior.

Development and evaluation of specific PCR primers targeting the ribosomal DNA-internal transcribed spacer (ITS) region of peritrich ciliates in environmental samples

NASA Astrophysics Data System (ADS)

Su, Lei; Zhang, Qianqian; Gong, Jun

2017-07-01

Peritrich ciliates are highly diverse and can be important bacterial grazers in aquatic ecosystems. Morphological identifications of peritrich species and assemblages in the environment are time-consuming and expertise-demanding. In this study, two peritrich-specific PCR primers were newly designed to amplify a fragment including the internal transcribed spacer (ITS) region of ribosomal rDNA from environmental samples. The primers showed high specificity in silico, and in tests with peritrich isolates and environmental DNA. Application of these primers in clone library construction and sequencing yielded exclusively sequences of peritrichs for water and sediment samples. We also found the ITS1, ITS2, ITS, D1 region of 28S rDNA, and ITS+D1 region co-varied with, and generally more variable than, the V9 region of 18S rDNA in peritrichs. The newly designed specific primers thus provide additional tools to study the molecular diversity, community composition, and phylogeography of these ecologically important protists in different systems.

A Well-Controlled Nucleus Pulposus Tissue Culture System with Injection Port for Evaluating Regenerative Therapies.

PubMed

Arkesteijn, Irene T M; Mouser, Vivian H M; Mwale, Fackson; van Dijk, Bart G M; Ito, Keita

2016-05-01

In vitro evaluation of nucleus pulposus (NP) tissue regeneration would be useful, but current systems for NP culture are not ideal for injections. The aim of this study was to develop a long-term culture system for NP tissue that allows injections of regenerative agents. Bovine caudal NPs were harvested and placed in the newly designed culture system. After equilibration of the tissue to 0.3 MPa the volume was fixed and the tissue was cultured for 28 days. The cell viability and extracellular matrix composition remained unchanged during the culture period and gene expression profiles were similar to those obtained in earlier studies. Furthermore, to test the responsiveness of bovine caudal NPs in the system, samples were cultured for 4 days and injected twice (day 1 and 3) with (1) PBS, (2) Link-N, for regeneration, and (3) TNF-α, for degeneration. It was shown that TNF-α increased COX2 gene expression, whereas no effect of Link-N was detected. In conclusion, the newly designed system allows long-term culture of NP tissue, wherein tissue reactions to injected stimulants can be observed.

Development of Tasks and Evaluation of a Prototype Forceps for NOTES

PubMed Central

Addis, Matthew; Aguirre, Milton; Haluck, Randy; Matthew, Abraham; Pauli, Eric; Gopal, Jegan

2012-01-01

Background and Objectives: Few standardized testing procedures exist for instruments intended for Natural Orifice Translumenal Endoscopic Surgery. These testing procedures are critical for evaluating surgical skills and surgical instruments to ensure sufficient quality. This need is widely recognized by endoscopic surgeons as a major hurdle for the advancement of Natural Orifice Translumenal Endoscopic Surgery. Methods: Beginning with tasks currently used to evaluate laparoscopic surgeons and instruments, new tasks were designed to evaluate endoscopic surgical forceps instruments. Results: Six tasks have been developed from existing tasks, adapted and modified for use with endoscopic instruments, or newly designed to test additional features of endoscopic forceps. The new tasks include the Fuzzy Ball Task, Cup Drop Task, Ring Around Task, Material Pull Task, Simulated Biopsy Task, and the Force Gauge Task. These tasks were then used to evaluate the performance of a new forceps instrument designed at Pennsylvania State University. Conclusions: The need for testing procedures for the advancement of Natural Orifice Translumenal Endoscopic Surgery has been addressed in this work. The developed tasks form a basis for not only testing new forceps instruments, but also for evaluating individual performance of surgical candidates with endoscopic forceps instruments. PMID:22906337

The development and testing of a brief ('gist-based') supplementary colorectal cancer screening information leaflet.

PubMed

Smith, Samuel G; Wolf, Michael S; Obichere, Austin; Raine, Rosalind; Wardle, Jane; von Wagner, Christian

2013-12-01

To design and user-test a 'gist-based' colorectal cancer screening information leaflet, which promotes comprehension of the screening offer. Twenty-eight individuals approaching screening age were recruited from organisations in deprived areas of England. Using a between-subjects design, we tested iterations of a newly-designed gist-based information leaflet. Participants read the leaflet and answered 8 'true' or 'false' comprehension statements. For the leaflet to be considered fit-for-purpose, all statements had to be answered correctly by at least 80% of participants in each round. Alterations were made if this threshold was not met and additional rounds of testing were undertaken. At round 1, answers to 2/8 statements did not meet the threshold. After changes, answers in round 2 did not reach the threshold for 1/8 statements. In round 3, all answers were adequate and the leaflet was deemed fit-for-purpose. Qualitative data offered solutions such as language and layout changes which led to improved comprehension of the leaflet. User-testing substantially improved the design and subsequent comprehensibility of a theory-driven gist-based colorectal cancer screening information leaflet. This leaflet will be evaluated as part of a large national randomised controlled trial designed to reduce socioeconomic inequalities in colorectal cancer screening participation. Copyright © 2013 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.

Parallel implementation of D-Phylo algorithm for maximum likelihood clusters.

PubMed

Malik, Shamita; Sharma, Dolly; Khatri, Sunil Kumar

2017-03-01

This study explains a newly developed parallel algorithm for phylogenetic analysis of DNA sequences. The newly designed D-Phylo is a more advanced algorithm for phylogenetic analysis using maximum likelihood approach. The D-Phylo while misusing the seeking capacity of k -means keeps away from its real constraint of getting stuck at privately conserved motifs. The authors have tested the behaviour of D-Phylo on Amazon Linux Amazon Machine Image(Hardware Virtual Machine)i2.4xlarge, six central processing unit, 122 GiB memory, 8  ×  800 Solid-state drive Elastic Block Store volume, high network performance up to 15 processors for several real-life datasets. Distributing the clusters evenly on all the processors provides us the capacity to accomplish a near direct speed if there should arise an occurrence of huge number of processors.

Development of a one-step RT-PCR assay for detection of pancoronaviruses (α-, β-, γ-, and δ-coronaviruses) using newly designed degenerate primers for porcine and avian `fecal samples.

PubMed

Hu, Hui; Jung, Kwonil; Wang, Qiuhong; Saif, Linda J; Vlasova, Anastasia N

2018-06-01

Coronaviruses (CoVs) are critical human and animal pathogens because of their potential to cause severe epidemics of respiratory or enteric diseases. In pigs, the newly emerged porcine deltacoronavirus (PDCoV) and re-emerged porcine epidemic diarrhea virus (PEDV) reported in the US and Asia, as well as the discovery of novel CoVs in wild bats or birds, has necessitated development of improved detection and control measures for these CoVs. Because the previous pancoronavirus (panCoV) RT-PCR established in our laboratory in 2007-2011 did not detect deltacoronaviruses (δ-CoVs) in swine fecal and serum samples, our goal was to develop a new panCoV RT-PCR assay to detect known human and animal CoVs, including δ-CoVs. In this study, we designed a new primer set to amplify a 668 bp-region within the RNA-dependent RNA polymerase (RdRP) gene that encodes the most conserved protein domain of α-, β-, γ-, and δ-CoVs. We established a one-step panCoV RT-PCR assay and standardized the assay conditions. The newly established panCoV RT-PCR assay was demonstrated to have a high sensitivity and specificity. Using a panel of 60 swine biological samples (feces, intestinal contents, and sera) characterized by PEDV, PDCoV and transmissible gastroenteritis virus-specific RT-PCR assays, we demonstrated that sensitivity and specificity of the newly established panCoV RT-PCR assay were 100%. 400 avian fecal (RNA) samples were further tested simultaneously for CoV by the new panCoV RT-PCR and a one-step RT-PCR assay with the δ-CoV nucleocapsid-specific universal primers. Four of 400 avian samples were positive for CoV, three of which were positive for δ-CoV by the conventional RT-PCR. PanCoV RT-PCR fragments for 3 of the 4 CoVs were sequenced. Phylogenetic analysis revealed the presence of one γ-CoV and two δ-CoV in the sequenced samples. The newly designed panCoV RT-PCR assay should be useful for the detection of currently known CoVs in animal biological samples. Copyright © 2018 Elsevier B.V. All rights reserved.

Long Duration Hot Hydrogen Exposure of Nuclear Thermal Rocket Materials

NASA Technical Reports Server (NTRS)

Litchford, Ron J.; Foote, John P.; Hickman, Robert; Dobson, Chris; Clifton, Scooter

2007-01-01

An arc-heater driven hyper-thermal convective environments simulator was recently developed and commissioned for long duration hot hydrogen exposure of nuclear thermal rocket materials. This newly established non-nuclear testing capability uses a high-power, multi-gas, wall-stabilized constricted arc-heater to .produce high-temperature pressurized hydrogen flows representative of nuclear reactor core environments, excepting radiation effects, and is intended to serve as a low cost test facility for the purpose of investigating and characterizing candidate fuel/structural materials and improving associated processing/fabrication techniques. Design and engineering development efforts are fully summarized, and facility operating characteristics are reported as determined from a series of baseline performance mapping runs and long duration capability demonstration tests.

Overview of NASA Lewis Research Center free-piston Stirling engine activities

NASA Technical Reports Server (NTRS)

Slaby, J. G.

1984-01-01

A generic free-piston Stirling technology project is being conducted to develop technologies generic to both space power and terrestrial heat pump applications in a cooperative, cost-shared effort. The generic technology effort includes extensive parametric testing of a 1 kW free-piston Stirling engine (RE-1000), development of a free-piston Stirling performance computer code, design and fabrication under contract of a hydraulic output modification for RE-1000 engine tests, and a 1000-hour endurance test, under contract, of a 3 kWe free-piston Stirling/alternator engine. A newly initiated space power technology feasibility demonstration effort addresses the capability of scaling a free-piston Stirling/alternator system to about 25 kWe; developing thermodynamic cycle efficiency or equal to 70 percent of Carnot at temperature ratios in the order of 1.5 to 2.0; achieving a power conversion unit specific weight of 6 kg/kWe; operating with noncontacting gas bearings; and dynamically balancing the system. Planned engine and component design and test efforts are described.

Computer-Automated Evolution of Spacecraft X-Band Antennas

NASA Technical Reports Server (NTRS)

Lohn, Jason D.; Homby, Gregory S.; Linden, Derek S.

2010-01-01

A document discusses the use of computer- aided evolution in arriving at a design for X-band communication antennas for NASA s three Space Technology 5 (ST5) satellites, which were launched on March 22, 2006. Two evolutionary algorithms, incorporating different representations of the antenna design and different fitness functions, were used to automatically design and optimize an X-band antenna design. A set of antenna designs satisfying initial ST5 mission requirements was evolved by use these algorithms. The two best antennas - one from each evolutionary algorithm - were built. During flight-qualification testing of these antennas, the mission requirements were changed. After minimal changes in the evolutionary algorithms - mostly in the fitness functions - new antenna designs satisfying the changed mission requirements were evolved and within one month of this change, two new antennas were designed and prototypes of the antennas were built and tested. One of these newly evolved antennas was approved for deployment on the ST5 mission, and flight-qualified versions of this design were built and installed on the spacecraft. At the time of writing the document, these antennas were the first computer-evolved hardware in outer space.

A Bayesian sequential design with adaptive randomization for 2-sided hypothesis test.

PubMed

Yu, Qingzhao; Zhu, Lin; Zhu, Han

2017-11-01

Bayesian sequential and adaptive randomization designs are gaining popularity in clinical trials thanks to their potentials to reduce the number of required participants and save resources. We propose a Bayesian sequential design with adaptive randomization rates so as to more efficiently attribute newly recruited patients to different treatment arms. In this paper, we consider 2-arm clinical trials. Patients are allocated to the 2 arms with a randomization rate to achieve minimum variance for the test statistic. Algorithms are presented to calculate the optimal randomization rate, critical values, and power for the proposed design. Sensitivity analysis is implemented to check the influence on design by changing the prior distributions. Simulation studies are applied to compare the proposed method and traditional methods in terms of power and actual sample sizes. Simulations show that, when total sample size is fixed, the proposed design can obtain greater power and/or cost smaller actual sample size than the traditional Bayesian sequential design. Finally, we apply the proposed method to a real data set and compare the results with the Bayesian sequential design without adaptive randomization in terms of sample sizes. The proposed method can further reduce required sample size. Copyright © 2017 John Wiley & Sons, Ltd.

DIFFERENTIATION OF SCHISTOSOMA HAEMATOBIUM FROM RELATED SCHISTOSOMES BY PCR AMPLIFYING AN INTER-REPEAT SEQUENCE

PubMed Central

ABBASI, IBRAHIM; KING, CHARLES H.; STURROCK, ROBERT F.; KARIUKI, CURTIS; MUCHIRI, ERIC; HAMBURGER, JOSEPH

2008-01-01

Schistosoma haematobium infects nearly 150 million people, primarily in Africa, and is transmitted by select species of local bulinid snails. These snails can host other related trematode species as well, so that effective detection and monitoring of snails infected with S. haematobium requires a successful differentiation between S. haematobium and any closely related schistosome species. To enable differential detection of S. haematobium DNA by simple polymerase chain reaction (PCR), we designed and tested primer pairs from numerous newly identified Schistosoma DNA repeat sequences. However, all pairs tested were found unsuitable for this purpose. Differentiation of S. haematobium from S. bovis, S. mattheei, S. curassoni, and S. intercalatum (but not from S. margrebowiei) was ultimately accomplished by PCR using one primer from a newly identified repeat, Sh110, and a second primer from a known schistosomal splice-leader sequence. For evaluation of residual S. haematobium transmission after control interventions, this differentiation tool will enable accurate monitoring of infected snails in areas where S. haematobium is sympatric with the most prevalent other schistosome species. PMID:17488921

Design, Activation, and Operation of the J2-X Subscale Simulator (JSS)

NASA Technical Reports Server (NTRS)

Saunders, Grady P.; Raines, Nickey G.; Varner, Darrel G.

2009-01-01

The purpose of this paper is to give a detailed description of the design, activation, and operation of the J2-X Subscale Simulator (JSS) installed in Cell 1 of the E3 test facility at Stennis Space Center, MS (SSC). The primary purpose of the JSS is to simulate the installation of the J2-X engine in the A3 Subscale Rocket Altitude Test Facility at SSC. The JSS is designed to give aerodynamically and thermodynamically similar plume properties as the J2-X engine currently under development for use as the upper stage engine on the ARES I and ARES V spacecraft. The JSS is a scale pressure fed, LOX/GH fueled rocket that is geometrically similar to the J2-X from the throat to the nozzle exit plane (NEP) and is operated at the same oxidizer to fuel ratios and chamber pressures. This paper describes the heritage hardware used as the basis of the JSS design, the newly designed rocket hardware, igniter systems used, and the activation and operation of the JSS.

HIV Testing, HIV Positivity, and Linkage and Referral Services in Correctional Facilities in the United States, 2009–2013

PubMed Central

Seth, Puja; Figueroa, Argelia; Wang, Guoshen; Reid, Laurie; Belcher, Lisa

2016-01-01

Background Because of health disparities, incarcerated persons are at higher risk for multiple health issues, including HIV. Correctional facilities have an opportunity to provide HIV services to an underserved population. This article describes Centers for Disease Control and Prevention (CDC)–funded HIV testing and service delivery in correctional facilities. Methods Data on HIV testing and service delivery were submitted to CDC by 61 health department jurisdictions in 2013. HIV testing, HIV positivity, receipt of test results, linkage, and referral services were described, and differences across demographic characteristics for linkage and referral services were assessed. Finally, trends were examined for HIV testing, HIV positivity, and linkage from 2009 to 2013. Results Of CDC-funded tests in 2013 among persons 18 years and older, 254,719 (7.9%) were conducted in correctional facilities. HIV positivity was 0.9%, and HIV positivity for newly diagnosed persons was 0.3%. Blacks accounted for the highest percentage of HIV-infected persons (1.3%) and newly diagnosed persons (0.5%). Only 37.9% of newly diagnosed persons were linked within 90 days; 67.5% were linked within any time frame; 49.7% were referred to partner services; and 45.2% were referred to HIV prevention services. There was a significant percent increase in HIV testing, overall HIV positivity, and linkage from 2009 to 2013. However, trends were stable for newly diagnosed persons. Conclusions Identification of newly diagnosed persons in correctional facilities has remained stable from 2009 to 2013. Correctional facilities seem to be reaching blacks, likely due to higher incarceration rates. The current findings indicate that improvements are needed in HIV testing strategies, service delivery during incarceration, and linkage to care postrelease. PMID:26462190

LLNL small-scale static spark machine: static spark sensitivity test

DOE Office of Scientific and Technical Information (OSTI.GOV)

Foltz, M F; Simpson, L R

1999-08-23

Small-scale safety testing of explosives and other energetic materials is done in order to determine their sensitivity to various stimuli, such as friction, static spark, and impact. Typically this testing is done to discover potential handling problems that may exist for either newly synthesized materials of unknown behavior, or materials that have been stored for long periods of time. This report describes the existing ''Static Spark Test Apparatus'' at Lawrence Livermore National Laboratory (LLNL), as well as the method used to evaluate the relative static spark sensitivity of energetic materials. The basic design, originally developed by the Picatinny Arsenal inmore » New Jersey, is discussed. The accumulated data for the materials tested to date is not included here, with the exception of specific examples that have yielded interesting or unusual results during the tests.« less

Characterization and Analysis of a Multicolor Quantum Well Infrared Photodetector

DTIC Science & Technology

2006-06-01

and characterization of performance of a newly designed, multicolor quantum well infrared photodetector ( QWIP ). Specifically, it focuses on a detector...quantum well infrared detectors makes them suitable for use in the field. 15. NUMBER OF PAGES 67 14. SUBJECT TERMS Quantum Well, QWIP , Three...characterization of performance of a newly designed, multicolor quantum well infrared photodetector ( QWIP ). Specifically, it focuses on a detector

Novel Flexible Plastic-Based Solar Cells

DTIC Science & Technology

2012-10-19

Fabrication of newly designed hybrid solar cells that are composed of a electron transport layer ( TiO2 ), a light sensitizing layer (NCs), and a hole...coating and spraying techniques, to produce broad-band light harvesting hybrid solar cells with bulk and layered heterojunction of inorganic...fabrication of hybrid bulk heterojunction photovoltaic cell using a blend film of polymer-inorganic NCs, 2) Fabrication of newly designed hybrid solar

Designing the STS-134 Re-Rendezvous: A Preparation for Future Crewed Rendezvous Missions

NASA Technical Reports Server (NTRS)

Stuit, Timothy D.

2011-01-01

In preparation to provide the capability for the Orion spacecraft, also known as the Multi-Purpose Crew Vehicle (MPCV), to rendezvous with the International Space Station (ISS) and future spacecraft, a new suite of relative navigation sensors are in development and were tested on one of the final Space Shuttle missions to ISS. The National Aeronautics and Space Administration (NASA) commissioned a flight test of prototypes of the Orion relative navigation sensors on STS-134, in order to test their performance in the space environment during the nominal rendezvous and docking, as well as a re-rendezvous dedicated to testing the prototype sensors following the undocking of the Space Shuttle orbiter at the end of the mission. Unlike the rendezvous and docking at the beginning of the mission, the re-rendezvous profile replicates the newly designed Orion coelliptic approach trajectory, something never before attempted with the shuttle orbiter. Therefore, there were a number of new parameters that needed to be conceived of, designed, and tested for this rerendezvous to make the flight test successful. Additionally, all of this work had to be integrated with the normal operations of the ISS and shuttle and had to conform to the constraints of the mission and vehicles. The result of this work is a separation and rerendezvous trajectory design that would not only prove the design of the relative navigation sensors for the Orion vehicle, but also would serve as a proof of concept for the Orion rendezvous trajectory itself. This document presents the analysis and decision making process involved in attaining the final STS-134 re-rendezvous design.

The Harvard Fatigue Laboratory: contributions to World War II.

PubMed

Folk, G Edgar

2010-09-01

The war contributions of the Harvard Fatigue Laboratory in Cambridge, MA, were recorded in 169 Technical Reports, most of which were sent to the Office of the Quartermaster General. Earlier reports were sent to the National Research Council and the Office of Scientific Research and Development. Many of the reports from 1941 and later dealt with either physical fitness of soldiers or the energetic cost of military tasks in extreme heat and cold. New military emergency rations to be manufactured in large quantities were analyzed in the Fatigue Laboratory and then tested in the field. Newly designed cold weather clothing was tested in the cold chamber at -40 degrees F, and desired improvements were made and tested in the field by staff and soldiers in tents and sleeping bags. Electrically heated clothing was designed for high-altitude flight crews and tested both in laboratory chambers and field tests before being issued. This eye witness account of the Harvard Fatigue Laboratory during World War II was recorded by Dr. G. Edgar Folk, who is likely the sole surviving member of that famous laboratory.

Vibration test of 1/5 scale H-II launch vehicle

NASA Astrophysics Data System (ADS)

Morino, Yoshiki; Komatsu, Keiji; Sano, Masaaki; Minegishi, Masakatsu; Morita, Toshiyuki; Kohsetsu, Y.

In order to predict dynamic loads on the newly designed Japanese H-II launch vehicle, the adequacy of prediction methods has been assessed by the dynamic scale model testing. The three-dimensional dynamic model was used in the analysis to express coupling effects among axial, lateral (pitch and yaw) and torsional vibrations. The liquid/tank interaction was considered by use of a boundary element method. The 1/5 scale model of the H-II launch vehicle was designed to simulate stiffness and mass properties of important structural parts, such as core/SRB junctions, first and second stage Lox tanks and engine mount structures. Modal excitation of the test vehicle was accomplished with 100-1000 N shakers which produced random or sinusoidal vibrational forces. The vibrational response of the test vehicle was measured at various locations with accelerometers and pressure sensor. In the lower frequency range, corresmpondence between analysis and experiment was generally good. The basic procedures in analysis seem to be adequate so far, but some improvements in mathematical modeling are suggested by comparison of test and analysis.

KSC-04PD-2684

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. The newly shod Crawler Transporter leaves tracks in the dirt as it moves forward on its road test. The Crawler Transporter that will move Space Shuttle Discovery to the launch pad for Return to Flight is taking its first road test following the replacement of all its shoes. The crawlers have 456 shoes, 57 per belt (8 belts in all). Each shoe weighs 2,200 pounds. Cracks appeared in the shoes in recent years, spurring a need for replacement. The new manufacturer, in Duluth, Minn., has improved the design for a safe Return to Flight and use through the balance of the Space Shuttle Program.

KSC-04PD-2685

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. The newly shod Crawler Transporter leaves tracks in the dirt as it moves forward on its road test. The Crawler Transporter that will move Space Shuttle Discovery to the launch pad for Return to Flight is taking its first road test following the replacement of all its shoes. The crawlers have 456 shoes, 57 per belt (8 belts in all). Each shoe weighs 2,200 pounds. Cracks appeared in the shoes in recent years, spurring a need for replacement. The new manufacturer, in Duluth, Minn., has improved the design for a safe Return to Flight and use through the balance of the Space Shuttle Program.

Construction and Validation of SRA-FV Need Assessment.

PubMed

Thornton, David; Knight, Raymond A

2015-08-01

This article describes the construction and testing of a newly designed instrument to assess psychological factors associated with increased rates of sexual recidivism. The new instrument (Structured Risk Assessment-Forensic Version or SRA-FV) was based on previous research using the SRA framework. This article describes the results of testing SRA-FV with a large sample (N = 566) of sexual offenders being evaluated for an early civil commitment program. SRA-FV was found to significantly predict sexual recidivism for both child molesters and rapists and to have incremental predictive value relative to two widely used static actuarial instruments (Static-99R; Risk Matrix 2000/S). © The Author(s) 2013.

Synthesis, crystal structures, fluorescence and xanthine oxidase inhibitory activity of pyrazole-based 1,3,4-oxadiazole derivatives

NASA Astrophysics Data System (ADS)

Qi, De-Qiang; Yu, Chuan-Ming; You, Jin-Zong; Yang, Guang-Hui; Wang, Xue-Jie; Zhang, Yi-Ping

2015-11-01

A series of pyrazole-based 1,3,4-oxadiazole derivatives were rationally designed and synthesized in good yields by following a convenient route. All the newly synthesized molecules were fully characterized by IR, 1H NMR and elemental analysis. Eight compounds were structurally determined by single crystal X-ray diffraction analysis. The fluorescence properties of all the compounds were investigated in dimethyl sulfoxide media. In addition, these newly synthesized compounds were evaluated for in vitro inhibitory activity against commercial enzyme xanthine oxidase (XO) by measuring the formation of uric acid from xanthine. Among the compounds synthesized and tested, 3d and 3e were found to be moderate inhibitory activity against commercial XO with IC50 = 72.4 μM and 75.6 μM. The studies gave a new insight in further optimization of pyrazole-based 1,3,4-oxadiazole derivatives with excellent fluorescence properties and XO inhibitory activity.

ARPA Semiannual Technical Report, Materials Science

DTIC Science & Technology

1973-12-15

determine the oscillator output properties. A newly designed cylindrical-ring-electrode Pockel’s cell is used for single picosecond pulse...satellite pulse trains and pulse noise. A contacted dye cell has been constructed and tested for this new system. Considerable experience in its ur-e...by the definition - - - -- ■’ -’ ’" - - ■ - - ■; - . v -• . . . -. 1.,-. •. • .’■-."■ ’,■■ . • ’*■ ," ’".** "."’" ", ■," ■T^r,T^" nT1

Defensive efficacy interim design: Dynamic benefit/risk ratio view using probability of success.

PubMed

Tang, Zhongwen

2017-01-01

Traditional efficacy interim design is based on alpha spending which does not have intuitive interpretation and hence is difficult to communicate with non-statistician colleagues. The alpha-spending approach is based on efficacy alone and hence does not have the flexibility to incorporate newly emerged safety signal. Newly emerged safety signal may nullify the originally set efficacy boundary. In contrast, the probability of success (POS) concept has intuitive interpretation and hence can facilitate our communication with non-statistician colleagues and help to obtain health authority (HA) buying. The success criteria of POS are not restricted to statistical significance. Hence, POS has the capability to incorporate both efficacy and safety information. We propose to use POS and its credible interval to design efficacy interim. In the proposed method, the efficacy boundary is adjustable to offset newly emerged safety signal.

A cluster randomized trial of provider-initiated (Opt-out) HIV counseling and testing of tuberculosis patients in South Africa

PubMed Central

Pope, Diana S.; DeLuca, Andrea N.; Kali, Paula; Hausler, Harry; Sheard, Carol; Hoosain, Ebrahim; Chaudhary, Mohammed A.; Celentano, David D.; Chaisson, Richard E.

2008-01-01

Objective To determine whether implementation of provider-initiated HIV counseling would increase the proportion of tuberculosis patients that received HIV counseling and testing. Design Cluster-randomized trial with clinic as unit of randomization Setting Twenty, medium-sized primary care TB clinics in the Nelson Mandela Metropolitan Municipality, Port Elizabeth, Eastern Cape Province, South Africa Subjects A total of 754 adults (≥ 18 years) newly registered as tuberculosis patients the twenty study clinics Intervention Implementation of provider-initiated HIV counseling and testing. Main outcome measures Percentage of TB patients HIV counseled and tested. Secondary Percentage of patients HIV test positive and percentage of those that received cotrimoxazole and who were referred for HIV care. Results A total of 754 adults newly registered as tuberculosis patients were enrolled. In clinics randomly assigned to implement provider-initiated HIV counseling and testing, 20.7% (73/352) patients were counseled versus 7.7% (31/402) in the control clinics (p = 0.011), and 20.2 % (n = 71) versus 6.5% (n = 26) underwent HIV testing (p = 0.009). Of those patients counseled, 97% in the intervention clinics accepted testing versus 79% in control clinics (p =0.12). The proportion of patients identified as HIV-infected in intervention clinics was 8.5% versus 2.5% in control clinics (p=0.044). Fewer than 40% of patients with a positive HIV test were prescribed cotrimoxazole or referred for HIV care in either study arm. Conclusions Provider-initiated HIV counseling significantly increased the proportion of adult TB patients that received HIV counseling and testing, but the magnitude of the effect was small. Additional interventions to optimize HIV testing for TB patients urgently need to be evaluated. PMID:18520677

Active member vibration control for a 4 meter primary reflector support structure

NASA Technical Reports Server (NTRS)

Umland, J. W.; Chen, G.-S.

1992-01-01

The design and testing of a new low voltage piezoelectric active member with integrated load cell and displacement sensor is described. This active member is intended for micron level vibration and structural shape control of the Precision Segmented Reflector test-bed. The test-bed is an erectable 4 meter diameter backup support truss for a 2.4 meter focal length parabolic reflector. Active damping of the test-bed is then demonstrated using the newly developed active members. The control technique used is referred to as bridge feedback. With this technique the internal sensors are used in a local feedback loop to match the active member's input impedance to the structure's load impedance, which then maximizes vibrational energy dissipation. The active damping effectiveness is then evaluated from closed loop frequency responses.

Cognitive Achievement and Motivation in Hands-on and Teacher-Centred Science Classes: Does an additional hands-on consolidation phase (concept mapping) optimise cognitive learning at work stations?

NASA Astrophysics Data System (ADS)

Gerstner, Sabine; Bogner, Franz X.

2010-05-01

Our study monitored the cognitive and motivational effects within different educational instruction schemes: On the one hand, teacher-centred versus hands-on instruction; on the other hand, hands-on instruction with and without a knowledge consolidation phase (concept mapping). All the instructions dealt with the same content. For all participants, the hands-on approach as well as the concept mapping adaptation were totally new. Our hands-on approach followed instruction based on "learning at work stations". A total of 397 high-achieving fifth graders participated in our study. We used a pre-test, post-test, retention test design both to detect students' short-term learning success and long-term learning success, and to document their decrease rates of newly acquired knowledge. Additionally, we monitored intrinsic motivation. Although the teacher-centred approach provided higher short-term learning success, hands-on instruction resulted in relatively lower decrease rates. However, after six weeks, all students reached similar levels of newly acquired knowledge. Nevertheless, concept mapping as a knowledge consolidation phase positively affected short-term increase in knowledge. Regularly placed in instruction, it might increase long-term retention rates. Scores of interest, perceived competence and perceived choice were very high in all the instructional schemes.

Influence of Cultural, Organizational, and Automation Capability on Human Automation Trust: A Case Study of Auto-GCAS Experimental Test Pilots

NASA Technical Reports Server (NTRS)

Koltai, Kolina; Ho, Nhut; Masequesmay, Gina; Niedober, David; Skoog, Mark; Cacanindin, Artemio; Johnson, Walter; Lyons, Joseph

2014-01-01

This paper discusses a case study that examined the influence of cultural, organizational and automation capability upon human trust in, and reliance on, automation. In particular, this paper focuses on the design and application of an extended case study methodology, and on the foundational lessons revealed by it. Experimental test pilots involved in the research and development of the US Air Force's newly developed Automatic Ground Collision Avoidance System served as the context for this examination. An eclectic, multi-pronged approach was designed to conduct this case study, and proved effective in addressing the challenges associated with the case's politically sensitive and military environment. Key results indicate that the system design was in alignment with pilot culture and organizational mission, indicating the potential for appropriate trust development in operational pilots. These include the low-vulnerability/ high risk nature of the pilot profession, automation transparency and suspicion, system reputation, and the setup of and communications among organizations involved in the system development.

The Japanese Positron Factory

NASA Astrophysics Data System (ADS)

Okada, S.; Sunaga, H.; Kaneko, H.; Takizawa, H.; Kawasuso, A.; Yotsumoto, K.; Tanaka, R.

1999-06-01

The Positron Factory has been planned at Japan Atomic Energy Research Institute (JAERI). The factory is expected to produce linac-based monoenergetic positron beams having world-highest intensities of more than 1010e+/sec, which will be applied for R&D of materials science, biotechnology and basic physics & chemistry. In this article, results of the design studies are demonstrated for the following essential components of the facilities: 1) Conceptual design of a high-power electron linac with 100 MeV in beam energy and 100 kW in averaged beam power, 2) Performance tests of the RF window in the high-power klystron and of the electron beam window, 3) Development of a self-driven rotating electron-to-positron converter and the performance tests, 4) Proposal of multi-channel beam generation system for monoenergetic positrons, with a series of moderator assemblies based on a newly developed Monte Carlo simulation and the demonstrative experiment, 5) Proposal of highly efficient moderator structures, 6) Conceptual design of a local shield to suppress the surrounding radiation and activation levels.

Space Shuttle Projects

NASA Image and Video Library

1989-06-03

The Marshall Space Flight Center (MSFC) engineers test fired a 26-foot long, 100,000-pound-thrust solid rocket motor for 30 seconds at the MSFC east test area, the first test firing of the Modified NASA Motor (M-NASA Motor). The M-NASA Motor was fired in a newly constructed stand. The motor is 48-inches in diameter and was loaded with two propellant cartridges weighing a total of approximately 12,000 pounds. The purpose of the test was to learn more about solid rocket motor insulation and nozzle materials and to provide young engineers additional hands-on expertise in solid rocket motor technology. The test is a part of NASA's Solid Propulsion Integrity Program, that is to provide NASA engineers with the techniques, engineering tools, and computer programs to be able to better design, build, and verify solid rocket motors.

Structural Optimization for Reliability Using Nonlinear Goal Programming

NASA Technical Reports Server (NTRS)

El-Sayed, Mohamed E.

1999-01-01

This report details the development of a reliability based multi-objective design tool for solving structural optimization problems. Based on two different optimization techniques, namely sequential unconstrained minimization and nonlinear goal programming, the developed design method has the capability to take into account the effects of variability on the proposed design through a user specified reliability design criterion. In its sequential unconstrained minimization mode, the developed design tool uses a composite objective function, in conjunction with weight ordered design objectives, in order to take into account conflicting and multiple design criteria. Multiple design criteria of interest including structural weight, load induced stress and deflection, and mechanical reliability. The nonlinear goal programming mode, on the other hand, provides for a design method that eliminates the difficulty of having to define an objective function and constraints, while at the same time has the capability of handling rank ordered design objectives or goals. For simulation purposes the design of a pressure vessel cover plate was undertaken as a test bed for the newly developed design tool. The formulation of this structural optimization problem into sequential unconstrained minimization and goal programming form is presented. The resulting optimization problem was solved using: (i) the linear extended interior penalty function method algorithm; and (ii) Powell's conjugate directions method. Both single and multi-objective numerical test cases are included demonstrating the design tool's capabilities as it applies to this design problem.

A novel method for direct solder bump pull testing using lead-free solders

NASA Astrophysics Data System (ADS)

Turner, Gregory Alan

This thesis focuses on the design, fabrication, and evaluation of a new method for testing the adhesion strength of lead-free solders, named the Isotraction Bump Pull method (IBP). In order to develop a direct solder joint-strength testing method that did not require customization for different solder types, bump sizes, specific equipment, or trial-and-error, a combination of two widely used and accepted standards was created. First, solder bumps were made from three types of lead free solder were generated on untreated copper PCB substrates using an in-house fabricated solder bump-on-demand generator, Following this, the newly developed method made use of a polymer epoxy to encapsulate the solder bumps that could then be tested under tension using a high precision universal vertical load machine. The tests produced repeatable and predictable results for each of the three alloys tested that were in agreement with the relative behavior of the same alloys using other testing methods in the literature. The median peak stress at failure for the three solders tested were 2020.52 psi, 940.57 psi, and 2781.0 psi, and were within one standard deviation of the of all data collected for each solder. The assumptions in this work that brittle fracture occurred through the Intermetallic Compound layer (IMC) were validated with the use of Energy-Dispersive X-Ray Spectrometry and high magnification of the fractured surface of both newly exposed sides of the test specimens. Following this, an examination of the process to apply the results from the tensile tests into standard material science equations for the fracture of the systems was performed..

A non-clinical randomised controlled trial to assess the impact of pharmaceutical care intervention on satisfaction level of newly diagnosed diabetes mellitus patients in a tertiary care teaching hospital in Nepal.

PubMed

Upadhyay, Dinesh Kumar; Mohamed Ibrahim, Mohamed Izham; Mishra, Pranaya; Alurkar, Vijay M

2015-02-12

Patient satisfaction is the ultimate goal of healthcare system which can be achieved from good patient-healthcare professional relationship and quality of healthcare services provided. Study was conducted to determine the baseline satisfaction level of newly diagnosed diabetics and to explore the impact of pharmaceutical care intervention on patients' satisfaction during their follow-ups in a tertiary care teaching hospital in Nepal. An interventional, pre-post non-clinical randomised controlled study was designed among randomly distributed 162 [control group (n = 54), test 1 group (n = 54) and test 2 group (n = 54)] newly diagnosed diabetes mellitus patients by consecutive sampling method for 18 months. Diabetes Patient Satisfaction Questionnaire was used to evaluate patient's satisfaction scores at baseline, three, six, nine and, twelve months' follow-ups. Test groups patients were provided pharmaceutical care whereas control group patients only received their usual care from physician/nurses. The responses were entered in SPSS version 16. Data distribution was not normal on Kolmogorov-Smirnov test. Non-parametric tests i.e. Friedman test, Mann-Whitney U test and Wilcoxon signed rank test were used to find the differences among the groups before and after the intervention (p ≤0.05). There were significant (p < 0.001) improvements in patients' satisfaction scores in the test groups on Friedman test. Mann-Whitney U test identified the significant differences in satisfaction scores between test 1 and test 2 groups, control and test 1 groups and, control and test 2 groups at 3-months (p = 0.008), (p < 0.001) and (p < 0.001), 6-months (p = 0.010), (p < 0.001) and (p < 0.001), 9-months (p < 0.001), (p < 0.001) and (p < 0.001) and, 12-months (p < 0.001), (p < 0.001) and (p < 0.001) follow-ups respectively. Pharmaceutical care intervention significantly improved the satisfaction level of diabetics in the test groups compare to the control group. Diabetic kit demonstration strengthened the satisfaction level among the test 2 group patients. Therefore, pharmacist can act as a counsellor through pharmaceutical care program and assist the patients in managing their disease. This will not only modify the patients' related outcomes and their level of satisfaction but also improve the healthcare system.

Effects of Lambertian sources design on uniformity and measurements

NASA Astrophysics Data System (ADS)

Cariou, Nadine; Durell, Chris; McKee, Greg; Wilks, Dylan; Glastre, Wilfried

2014-10-01

Integrating sphere (IS) based uniform sources are a primary tool for ground based calibration, characterization and testing of flight radiometric equipment. The idea of a Lambertian field of energy is a very useful tool in radiometric testing, but this concept is being checked in many ways by newly lowered uncertainty goals. At an uncertainty goal of 2% one needs to assess carefully uniformity in addition to calibration uncertainties, as even sources with a 0.5% uniformity are now substantial proportions of uncertainty budgets. The paper explores integrating sphere design options for achieving 99.5% and better uniformity of exit port radiance and spectral irradiance created by an integrating sphere. Uniformity in broad spectrum and spectral bands are explored. We discuss mapping techniques and results as a function of observed uniformity as well as laboratory testing results customized to match with customer's instrumentation field of view. We will also discuss recommendations with basic commercial instrumentation, we have used to validate, inspect, and improve correlation of uniformity measurements with the intended application.

PtRu nanoparticles embedded in nitrogen doped carbon with highly stable CO tolerance and durability

NASA Astrophysics Data System (ADS)

Ling, Ying; Yang, Zehui; Yang, Jun; Zhang, Yunfeng; Zhang, Quan; Yu, Xinxin; Cai, Weiwei

2018-02-01

As is well known, the lower durability and sluggish methanol oxidation reaction (MOR) of PtRu alloy electrocatalyst blocks the commercialization of direct methanol fuel cells (DMFCs). Here, we design a new PtRu electrocatalyst, with highly stable CO tolerance and durability, in which the PtRu nanoparticles are embedded in nitrogen doped carbon layers derived from carbonization of poly(vinyl pyrrolidone). The newly fabricated electrocatalyst exhibits no loss in electrochemical surface area (ECSA) and MOR activity after potential cycling from 0.6-1.0 V versus reversible hydrogen electrode, while commercial CB/PtRu retains only 50% of its initial ECSA. Meanwhile, due to the same protective layers, the Ru dissolution is decelerated, resulting in stable CO tolerance. Methanol oxidation reaction (MOR) testing indicates that the activity of newly fabricated electrocatalyst is two times higher than that of commercial CB/PtRu, and the fuel cell performance of the embedded PtRu electrocatalyst was comparable to that of commercial CB/PtRu. The embedded PtRu electrocatalyst is applicable in real DMFC operation. This study offers important and useful information for the design and fabrication of durable and CO tolerant electrocatalysts.

A New Primer to Amplify pmoA Gene From NC10 Bacteria in the Sediments of Dongchang Lake and Dongping Lake.

PubMed

Wang, Shenghui; Liu, Yanjun; Liu, Guofu; Huang, Yaru; Zhou, Yu

2017-08-01

Nitrite-dependent anaerobic methane oxidation (n-damo) is catalyzed by the NC10 phylum bacterium "Candidatus Methylomirabilis oxyfera" (M. oxyfera). Generally, the pmoA gene is applied as a functional marker to test and identify NC10-like bacteria. However, it is difficult to detect the NC10 bacteria from sediments of freshwater lake (Dongchang Lake and Dongping Lake) with the previous pmoA gene primer sets. In this work, a new primer cmo208 was designed and used to amplify pmoA gene of NC10-like bacteria. A newly nested PCR approach was performed using the new primer cmo208 and the previous primers cmo182, cmo682, and cmo568 to detect the NC10 bacteria. The obtained pmoA gene sequences exhibited 85-92% nucleotide identity and 95-97% amino acid sequence identity to pmoA gene of M. oxyfera. The obtained diversity of pmoA gene sequences coincided well with the diversity of 16S rRNA sequences. These results indicated that the newly designed pmoA primer cmo208 could give one more option to detect NC10 bacteria from different environmental samples.

Upscaling the pollutant emission from mixed recycled aggregates under compaction for civil applications.

PubMed

Galvín, Adela P; Ayuso, Jesús; Barbudo, Auxi; Cabrera, Manuel; López-Uceda, Antonio; Rosales, Julia

2017-12-27

In general terms, plant managers of sites producing construction wastes assess materials according to concise, legally recommended leaching tests that do not consider the compaction stage of the materials when they are applied on-site. Thus, the tests do not account for the real on-site physical conditions of the recycled aggregates used in civil works (e.g., roads or embankments). This leads to errors in estimating the pollutant potential of these materials. For that reason, in the present research, an experimental procedure is designed as a leaching test for construction materials under compaction. The aim of this laboratory test (designed specifically for the granular materials used in civil engineering infrastructures) is to evaluate the release of pollutant elements when the recycled aggregate is tested at its commercial grain-size distribution and when the material is compacted under on-site conditions. Two recycled aggregates with different gypsum contents (0.95 and 2.57%) were used in this study. In addition to the designed leaching laboratory test, the conventional compliance leaching test and the Dutch percolation test were performed. The results of the new leaching method were compared with the conventional leaching test results. After analysis, the chromium and sulphate levels obtained from the newly designed test were lower than those obtained from the conventional leaching test, and these were considered more seriously pollutant elements. This result confirms that when the leaching behaviour is evaluated for construction aggregates without density alteration, crushing the aggregate and using only the finest fraction, as is done in the conventional test (which is an unrealistic situation for aggregates that are applied under on-site conditions), the leaching behaviour is not accurately assessed.

Optical metrology at the Optical Sciences Center: an historical review

NASA Astrophysics Data System (ADS)

Creath, Katherine; Parks, Robert E.

2014-10-01

The Optical Sciences Center (OSC) begun as a graduate-level applied optics teaching institution to support the US space effort. The making of optics representative of those used in other space programs was deemed essential. This led to the need for optical metrology: at first Hartmann tests, but almost immediately to interferometric tests using the newly invented HeNe laser. Not only were new types of interferometers needed, but the whole infrastructure that went with testing, fringe location methods, aberration removal software and contour map generation to aid the opticians during polishing needed to be developed. Over the last half century more rapid and precise methods of interferogram data reduction, surface roughness measurement, and methods of instrument calibration to separate errors from those in the optic have been pioneered at OSC. Other areas of research included null lens design and the writing of lens design software that led into the design of computer generated holograms for asphere testing. More recently work has been done on the reduction of speckle noise in interferograms, methods to test large convex aspheres, and a return to slope measuring tests to increase the dynamic range of the types of aspheric surfaces amenable to optical testing including free-form surfaces. This paper documents the history of the development of optical testing projects at OSC and highlights the contributions some of the individuals associated with new methods of testing and the infrastructure needed to support the testing. We conclude with comments about the future trends optical metrology.

Detection of West Nile virus and tick-borne encephalitis virus in birds in Slovakia, using a universal primer set.

PubMed

Csank, Tomáš; Bhide, Katarína; Bencúrová, Elena; Dolinská, Saskia; Drzewnioková, Petra; Major, Peter; Korytár, Ľuboš; Bocková, Eva; Bhide, Mangesh; Pistl, Juraj

2016-06-01

West Nile virus (WNV) is a mosquito-borne neurotropic pathogen that presents a major public health concern. Information on WNV prevalence and circulation in Slovakia is insufficient. Oral and cloacal swabs and bird brain samples were tested for flavivirus RNA by RT-PCR using newly designed generic primers. The species designation was confirmed by sequencing. WNV was detected in swab and brain samples, whereas one brain sample was positive for tick-borne encephalitis virus (TBEV). The WNV sequences clustered with lineages 1 and 2. These results confirm the circulation of WNV in birds in Slovakia and emphasize the risk of infection of humans and horses.

Methods of measuring water levels in deep wells

USGS Publications Warehouse

Garber, M.S.; Koopman, F. C.

1968-01-01

Accurate measurement of water levels deeper than 1,000 feet in wells requires specialized equipment. Corrections for stretch and thermal expansion of measuring tapes must be considered, and other measuring devices must be calibrated periodically. Bore-hole deviation corrections also must be made. Devices for recording fluctuation of fluid level usually require mechanical modification for use at these depths. A multichannel recording device utilizing pressure transducers has been constructed. This device was originally designed to record aquifer response to nearby underground nuclear explosions but can also be used for recording data from multi-well pumping tests. Bottom-hole recording devices designed for oil-field use have been utilized in a limited manner. These devices were generally found to lack the precision required, in ground-water investigations at the Nevada Test Site but may be applicable in other areas. A newly developed bottom-hole recording pressure gauge of improved accuracy has been used with satisfactory results.

Design and testing of a low impedance transceiver circuit for nitrogen-14 nuclear quadrupole resonance.

PubMed

Sato-Akaba, Hideo

2014-01-01

A low impedance transceiver circuit consisting of a transmit-receive switch circuit, a class-D amplifier and a transimpedance amplifier (TIA) was newly designed and tested for a nitrogen-14 NQR. An NQR signal at 1.37MHz from imidazole was successfully observed with the dead time of ~85µs under the high Q transmission (Q~120) and reception (Q~140). The noise performance of the low impedance TIA with an NQR probe was comparable with a commercial low noise 50Ω amplifier (voltage input noise: 0.25 nV/Hz) which was also connected to the probe. The protection voltage for the pre-amplifier using the low impedance transceiver was ~10 times smaller than that for the pre-amplifier using a 50Ω conventional transceiver, which is suitable for NQR remote sensing applications. Copyright © 2014 Elsevier Inc. All rights reserved.

A Newly Designed Tennis Elbow Orthosis With a Traditional Tennis Elbow Strap in Patients With Lateral Epicondylitis

PubMed Central

Saremi, Hossein; Chamani, Vahid; Vahab-Kashani, Reza

2016-01-01

Background Lateral epicondylitis is a common cause of pain and upper limb dysfunction. The use of counterforce straps for treatment of lateral epicondylitis is widespread. This kind of orthosis can be modified to have a greater effect on relieving pain by reducing tension on the origin of the extensor pronator muscles. Objectives To determine the immediate effects of a newly designed orthosis on pain and grip strength in patients with lateral epicondylitis. Materials and Methods Twelve participants (six men and six women) were recruited (mean age = 41 ± 6.7 years) and evaluated for pain and grip strength in three sessions. A 48-hour break was taken between each session. The first session was without any orthosis, the second session was with the new modified tennis elbow orthosis, and the third session was with a conventional tennis elbow strap. Results Both counterforce straps were effective. However, significantly more improvement was observed in pain and grip strength after using the newly modified orthosis (P < 0.05). Conclusions The newly designed strap reduces pain more effectively and improves grip strength by causing greater localized pressure on two regions with different force applications (two component vectors versus one). PMID:28180116

Design, testing, and installation of a high-precision hexapod for the Hobby-Eberly Telescope dark energy experiment (HETDEX)

NASA Astrophysics Data System (ADS)

Zierer, Joseph J.; Beno, Joseph H.; Weeks, Damon A.; Soukup, Ian M.; Good, John M.; Booth, John A.; Hill, Gary J.; Rafal, Marc D.

2012-09-01

Engineers from The University of Texas at Austin Center for Electromechanics and McDonald Observatory have designed, built, and laboratory tested a high payload capacity, precision hexapod for use on the Hobby-Eberly telescope as part of the HETDEX Wide Field Upgrade (WFU). The hexapod supports the 4200 kg payload which includes the wide field corrector, support structure, and other optical/electronic components. This paper provides a recap of the hexapod actuator mechanical and electrical design including a discussion on the methods used to help determine the actuator travel to prevent the hexapod payload from hitting any adjacent, stationary hardware. The paper describes in detail the tooling and methods used to assemble the full hexapod, including many of the structures and components which are supported on the upper hexapod frame. Additionally, details are provided on the installation of the hexapod onto the new tracker bridge, including design decisions that were made to accommodate the lift capacity of the Hobby- Eberly Telescope dome crane. Laboratory testing results will be presented verifying that the performance goals for the hexapod, including positioning, actuator travel, and speeds have all been achieved. This paper may be of interest to mechanical and electrical engineers responsible for the design and operations of precision hardware on large, ground based telescopes. In summary, the hexapod development cycle from the initial hexapod actuator performance requirements and design, to the deployment and testing on the newly designed HET tracker system is all discussed, including lessons learned through the process.

Comparison of flow and gas washout characteristics between pressure control and high-frequency percussive ventilation using a test lung

PubMed Central

Dutta, Rabijit; Xing, Tao; Swanson, Craig; Heltborg, Jeff; Murdoch, Gordon K

2018-01-01

Objective A comparison between flow and gas washout data for high-frequency percussive ventilation (HFPV) and pressure control ventilation (PCV) under similar conditions is currently not available. This bench study aims to compare and describe the flow and gas washout behavior of HFPV and PCV in a newly designed experimental setup and establish a framework for future clinical and animal studies. Approach We studied gas washout behavior using a newly designed experimental setup that is motivated by the multi-breath nitrogen washout measurements. In this procedure, a test lung was filled with nitrogen gas before it was connected to a ventilator. Pressure, volume, and oxygen concentrations were recorded under different compliance and resistance conditions. PCV was compared with two settings of HFPV, namely, HFPV-High and HFPV-Low, to simulate the different variations in its clinical application. In the HFPV-Low mode, the peak pressures and drive pressures of HFPV and PCV are matched, whereas in the HFPV-High mode, the mean airway pressures (MAP) are matched. Main results HFPV-Low mode delivers smaller tidal volume (VT) as compared to PCV under all lung conditions, whereas HFPV-High delivers a larger VT. HFPV-High provides rapid washout as compared to PCV under all lung conditions. HFPV-Low takes a longer time to wash out nitrogen except at a low compliance, where it expedites washout at a smaller VT and MAP compared to PCV washout. Significance Various flow parameters for HFPV and PCV are mathematically defined. A shorter washout time at a small VT in low compliant test lungs for HFPV could be regarded as a hypothesis for lung protective ventilation for animal or human lungs. PMID:29369819

Comparison of flow and gas washout characteristics between pressure control and high-frequency percussive ventilation using a test lung.

PubMed

Dutta, Rabijit; Xing, Tao; Swanson, Craig; Heltborg, Jeff; Murdoch, Gordon K

2018-03-15

A comparison between flow and gas washout data for high-frequency percussive ventilation (HFPV) and pressure control ventilation (PCV) under similar conditions is currently not available. This bench study aims to compare and describe the flow and gas washout behavior of HFPV and PCV in a newly designed experimental setup and establish a framework for future clinical and animal studies. We studied gas washout behavior using a newly designed experimental setup that is motivated by the multi-breath nitrogen washout measurements. In this procedure, a test lung was filled with nitrogen gas before it was connected to a ventilator. Pressure, volume, and oxygen concentrations were recorded under different compliance and resistance conditions. PCV was compared with two settings of HFPV, namely, HFPV-High and HFPV-Low, to simulate the different variations in its clinical application. In the HFPV-Low mode, the peak pressures and drive pressures of HFPV and PCV are matched, whereas in the HFPV-High mode, the mean airway pressures (MAP) are matched. HFPV-Low mode delivers smaller tidal volume (V T ) as compared to PCV under all lung conditions, whereas HFPV-High delivers a larger V T . HFPV-High provides rapid washout as compared to PCV under all lung conditions. HFPV-Low takes a longer time to wash out nitrogen except at a low compliance, where it expedites washout at a smaller V T and MAP compared to PCV washout. Various flow parameters for HFPV and PCV are mathematically defined. A shorter washout time at a small V T in low compliant test lungs for HFPV could be regarded as a hypothesis for lung protective ventilation for animal or human lungs.

Imparting Barely Visible Impact Damage to a Stitched Composite Large-Scale Pressure Box

NASA Technical Reports Server (NTRS)

Lovejoy, Andrew E.; Przekop, Adam

2016-01-01

The Pultruded Rod Stitched Efficient Unitized Structure (PRSEUS) is a concept that was developed by The Boeing Company to address the complex structural design aspects associated with a pressurized hybrid wing body (HWB) aircraft configuration, which has been a focus of the NASA Environmentally Responsible Aviation Project. The NASA-Boeing structural development for the HWB aircraft culminated in testing of the multi-bay box, which is an 80%-scale representation of the pressurized center-body section. This structure was tested in the NASA Langley Research Center Combined Loads Test System facility. As part of this testing, barely visible impact damage was imparted to the interior and exterior of the test article to demonstrate compliance with a condition representative of the requirements for Category 1 damaged composite structure as defined by the Federal Aviation Regulations. Interior impacts were imparted using an existing spring-loaded impactor, while the exterior impacts were imparted using a newly designed, gravity-driven impactor. This paper describes the impacts to the test article, and the design of the gravitydriven guided-weight impactor. The guided-weight impactor proved to be a very reliable method to impart barely visible impact damage in locations which are not easily accessible for a traditional drop-weight impactor, while at the same time having the capability to be highly configurable for use on other aircraft structures.

Robustness enhancement of neurocontroller and state estimator

NASA Technical Reports Server (NTRS)

Troudet, Terry

1993-01-01

The feasibility of enhancing neurocontrol robustness, through training of the neurocontroller and state estimator in the presence of system uncertainties, is investigated on the example of a multivariable aircraft control problem. The performance and robustness of the newly trained neurocontroller are compared to those for an existing neurocontrol design scheme. The newly designed dynamic neurocontroller exhibits a better trade-off between phase and gain stability margins, and it is significantly more robust to degradations of the plant dynamics.

Flight test experience with high-alpha control system techniques on the F-14 airplane

NASA Technical Reports Server (NTRS)

Gera, J.; Wilson, R. J.; Enevoldson, E. K.; Nguyen, L. T.

1981-01-01

Improved handling qualities of fighter aircraft at high angles of attack can be provided by various stability and control augmentation techniques. NASA and the U.S. Navy are conducting a joint flight demonstration of these techniques on an F-14 airplane. This paper reports on the flight test experience with a newly designed lateral-directional control system which suppresses such high angle of attack handling qualities problems as roll reversal, wing rock, and directional divergence while simultaneously improving departure/spin resistance. The technique of integrating a piloted simulation into the flight program was used extensively in this program. This technique had not been applied previously to high angle of attack testing and required the development of a valid model to simulate the test airplane at extremely high angles of attack.

Evaluation of new chlorhexidine- and cetylpyridinium chloride-based mouthrinse formulations adjunctive to scaling and root planing: pilot study.

PubMed

García-Gargallo, M; Zurlohe, M; Montero, E; Alonso, B; Serrano, J; Sanz, M; Herrera, D

2017-11-01

To compare the effect of two newly formulated chlorhexidine (CHX) and cetylpyridinium chloride (CPC) mouthrinses after scaling and root planing (SRP) in terms of clinical, microbiological, patient-based variables and adverse events, with a positive control with the same active components, already marketed and tested. A pilot, randomized clinical trial, double-blind, parallel design with 1-month follow-up was conducted. Chronic periodontitis patients requiring non-surgical periodontal therapy were enrolled and randomly assigned to: (i) SRP and test-1 (new reformulation: 0.12% CHX and 0.05% CPC); (ii) SRP and test-2 (new formulation: 0.03% CHX and 0.05% CPC); or (iii) SRP and positive control (commercial product: 0.12% CHX and 0.05% CPC). All variables were evaluated at baseline and 1 month after SRP. Quantitative variables were compared by means of anova or Kruskal-Wallis test and qualitative variables by chi-square or McNemar tests. Thirty patients (10 per group) were included. After 1 month, there were significant differences among groups in plaque levels (P = 0.016) as test-1 showed less sites with plaque than test-2 (31.15% [standard error-SE 2.21%] versus 49.39% [SE 4.60%), respectively). No significant differences were found for global patient perception of the product or in adverse effects. Test groups showed better results in levels and proportions (P = 0.022) of Capnocytophaga spp. Within the limitations of this pilot study, it can be concluded that the newly formulated 0.12% CHX and 0.05% CPC mouthrinse showed larger plaque level reductions, without showing more adverse effects, when compared to the other two mouthrinses, after SRP. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Compact Heat Exchanger Design and Testing for Advanced Reactors and Advanced Power Cycles

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sun, Xiaodong; Zhang, Xiaoqin; Christensen, Richard

The goal of the proposed research is to demonstrate the thermal hydraulic performance of innovative surface geometries in compact heat exchangers used as intermediate heat exchangers (IHXs) and recuperators for the supercritical carbon dioxide (s-CO 2) Brayton cycle. Printed-circuit heat exchangers (PCHEs) are the primary compact heat exchangers of interest. The overall objectives are: To develop optimized PCHE designs for different working fluid combinations including helium to s-CO 2, liquid salt to s-CO 2, sodium to s-CO 2, and liquid salt to helium; To experimentally and numerically investigate thermal performance, thermal stress and failure mechanism of PCHEs under various transients;more » and To study diffusion bonding techniques for elevated-temperature alloys and examine post-test material integrity of the PCHEs. The project objectives were accomplished by defining and executing five different tasks corresponding to these specific objectives. The first task involved a thorough literature review and a selection of IHX candidates with different surface geometries as well as a summary of prototypic operational conditions. The second task involved optimization of PCHE design with numerical analyses of thermal-hydraulic performances and mechanical integrity. The subsequent task dealt with the development of testing facilities and engineering design of PCHE to be tested in s-CO 2 fluid conditions. The next task involved experimental investigation and validation of the thermal-hydraulic performances and thermal stress distribution of prototype PCHEs manufactured with particular surface geometries. The last task involved an investigation of diffusion bonding process and posttest destructive testing to validate mechanical design methods adopted in the design process. The experimental work utilized the two test facilities at The Ohio State University (OSU) including one existing High-Temperature Helium Test Facility (HTHF) and the newly developed s-CO 2 test loop (STL) facility and s-CO 2 test facility at University of Wisconsin – Madison (UW).« less

Design of low noise wind turbine blades using Betz and Joukowski concepts

NASA Astrophysics Data System (ADS)

Shen, W. Z.; Hrgovan, I.; Okulov, V.; Zhu, W. J.; Madsen, J.

2014-06-01

This paper presents the aerodynamic design of low noise wind turbine blades using Betz and Joukowski concepts. The aerodynamic model is based on Blade Element Momentum theory whereas the aeroacoustic prediction model is based on the BPM model. The investigation is started with a 3MW baseline/reference turbine rotor with a diameter of 80 m. To reduce the noise emission from the baseline rotor, the rotor is reconstructed with the low noise CQU-DTU-LN1 series of airfoils which has been tested in the acoustic wind tunnel located at Virginia Tech. Finally, 3MW low noise turbine rotors are designed using the concepts of Betz and Joukowski, and the CQU-DTU-LN1 series of airfoils. Performance analysis shows that the newly designed turbine rotors can achieve an overall noise reduction of 6 dB and 1.5 dB(A) with a similar power output as compared to the reference rotor.

New application of plate-fin heat exchanger with regenerative cryocoolers

NASA Astrophysics Data System (ADS)

Chang, Ho-Myung; Gwak, Kyung Hyun

2015-09-01

A design idea is newly proposed and investigated for the application of plate-fin heat exchanger (PFHX) with regenerative cryocoolers. The role of this heat exchanger is to effectively absorb heat from the stream of coolant and deliver it to the cold-head of a cryocooler. While various types of tubular HX's have been developed so far, a small PFHX could be more useful for this purpose by taking advantage of compactness and design flexibility. In order to confirm the feasibility and effectiveness, a prototype of aluminum-brazed PFHX is designed, fabricated, and tested with a single-stage GM cryocooler in experiments for subcooling liquid nitrogen from 78 K to 65-70 K. The results show that the PFHX is 30-50% more effective in cooling rate than the tubular HX's. Several potential applications of PFHX are presented and discussed with specific design concepts.

Newberry Well 55-29 Stimulation Data 2014

DOE Data Explorer

Trenton T. Cladouhos

2015-09-03

The Newberry Volcano EGS Demonstration in central Oregon, a 5 year project begun in 2010, tests recent technological advances designed to reduce the cost of power generated by EGS in a hot, dry well (NWG 55-29) drilled in 2008. First, the stimulation pumps used were designed to run for weeks and deliver large volumes of water at moderate well-head pressure. Second, to stimulate multiple zones, AltaRock developed thermo-degradable zonal isolation materials (TZIMs) to seal off fractures in a geothermal well to stimulate secondary and tertiary fracture zones. The TZIMs degrade within weeks, resulting in an optimized injection/ production profile of the entire well. Third, the project followed a project-specific Induced Seismicity Mitigation Plan (ISMP) to evaluate, monitor for, and mitigate felt induced seismicity. An initial stimulation was conducted in 2012 and continued for 7 weeks, with over 41,000 m3 of water injected. Further analysis indicated a shallow casing leak and an unstable formation in the open hole. The well was repaired with a shallow casing tieback and perforated liner in the open hole and re-stimulated in 2014. The second stimulation started September 23rd, 2014 and continued for 3 weeks with over 9,500 m3 of water injected. The well was treated with several batches of newly tested TZIM diverter materials and a newly designed Diverter Injection Vessel Assembly (DIVA), which was the main modification to the original injection system design used in 2012. A second round of stimulation that included two perforation shots and additional batches of TZIM was conducted on November 11th, 2014 for 9 days with an additional 4,000 m3 of water injected. The stimulations resulted in a 3-4 fold increase in injectivity, and PTS data indicates partial blocking and creation of flow zones near the bottom of the well.

Lessons Learned: Newly Hired Nurses' Perspectives on Transition Into Practice.

PubMed

Ziebert, Carolyn; Klingbeil, Carol; Schmitt, Catherine A; Stonek, Alice V; Totka, Joan P; Stelter, Ashley; Schiffman, Rachel F

2016-01-01

This descriptive qualitative study explored data from debriefs of all newly hired nurses at 3, 6, and 12 months posthire during a newly designed transition-to-practice program at a pediatric hospital. Four major themes emerged: preceptors, education process, adaptation to the organization, and role transition. Supportive factors included staged orientation, limited preceptors, mentors, regular communication with leaders, and a culture of teamwork. Stressors included too many preceptors, mentorship needs, floating, communication challenges, and organizational changes.

Antimicrobial activity of N-alkoxycarbonylmethyl-N-alkyl-piperidinium chlorides.

PubMed

Woźniak, Edyta; Mozrzymas, Anna; Czarny, Anna; Kocieba, Maja; Rózycka-Roszak, Bozenna; Dega-Szafran, Zofia; Dulewicz, Ewa; Petryna, Magdalena

2004-01-01

The aim of the study was to assay antibacterial and antifungal activity of newly synthesised N-alkoxycarbonylmethyl-N-alkyl-piperidinium chlorides. The compounds tested were found to inhibit the growth of some Gram-negative bacteria, Gram-positive strains and some representatives of yeast-type Candida. From microbiological experiments two of the compounds tested, N-dodecyloxycarbonylmethyl-N-methyl-piperidinium chloride (3) and N-dodecyl-N-ethoxycarbonylmethyl-piperidinium chloride (6), emerged as more active than the other compounds. Since the resistance of biofilms to biocides should be noted during the design and testing of new antimicrobial agents therefore, we have analysed antibacterial properties of the most active compounds towards biofilms. Our study focused on strains of Pseudomonas aeruginosa and Staphylococcus aureus that served as main model organisms for the biofilm studies.

Innovative remotely-controlled bending device for thin silicon and germanium crystals

NASA Astrophysics Data System (ADS)

De Salvador, D.; Carturan, S.; Mazzolari, A.; Bagli, E.; Bandiera, L.; Durighello, C.; Germogli, G.; Guidi, V.; Klag, P.; Lauth, W.; Maggioni, G.; Romagnoni, M.; Sytov, A.

2018-04-01

Steering of negatively charged particle beams below 1 GeV has demonstrated to be possible with thin bent silicon and germanium crystals. A newly designed mechanical holder was used for bending crystals, since it allows a remotely-controlled adjustment of crystal bending and compensation of unwanted torsion. Bent crystals were installed and tested at the MAMI Mainz MIcrotron to achieve steering of 0.855-GeV electrons at different bending radii. We report the description and characterization of the innovative bending device developed at INFN Laboratori Nazionali di Legnaro (LNL).

Thermal design verification testing of the Clementine spacecraft: Quick, cheap, and useful

NASA Technical Reports Server (NTRS)

Kim, Jeong H.; Hyman, Nelson L.

1994-01-01

At this writing, Clementine had successfully fulfilled its moon-mapping mission; at this reading it will have also, with continued good fortune, taken a close look at the asteroid Geographos. The thermal design that made all this possible was indeed formidable in many respects, with very high ratios of requirements-to-available resources and performance-to-cost and mass. There was no question that a test verification of this quite unique and complex design was essential, but it had to be squeezed into an unyielding schedule and executed with bare-bones cost and manpower. After describing the thermal control subsystem's features, we report all the drama, close-calls, and cost-cutting, how objectives were achieved under severe handicap but (thankfully) with little management and documentation interference. Topics include the newly refurbished chamber (ready just in time), the reality level of the engineering model, using the analytical thermal model, the manner of environment simulation, the hand-scratched film heaters, functioning of all three types of heat pipes (but not all heat pipes), and the BMDO sensors' checkout through the chamber window. Test results revealed some surprises and much valuable data, resulting in thermal model and flight hardware refinements. We conclude with the level of correlation between predictions and both test temperatures and flight telemetry.

Principles and practices of irradiation creep experiment using pressurized mini-bellows

DOE Office of Scientific and Technical Information (OSTI.GOV)

Byun, Thak Sang; Li, Meimei; Snead, Lance Lewis

2013-01-01

This article is to describe the key design principles and application practices of the newly developed in-reactor irradiation creep testing technology using pressurized mini-bellows. Miniature creep test frames were designed to fit into the high flux isotope reactor (HFIR) rabbit capsule whose internal diameter is slightly less than 10 mm. The most important consideration for this in-reactor creep testing technology was the ability of the small pressurized metallic bellows to survive irradiation at elevated temperatures while maintaining applied load to the specimen. Conceptual designs have been developed for inducing tension and compression stresses in specimens. Both the theoretical model andmore » the in-furnace test confirmed that a gas-pressurized bellows can produce high enough stress to induce irradiation creep in subsize specimens. Discussion focuses on the possible stress range in specimens induced by the miniature gas-pressurized bellows and the limitations imposed by the size and structure of thin-walled bellows. A brief introduction to the in-reactor creep experiment for graphite is provided to connect to the companion paper describing the application practices and irradiation creep data. An experimental and calculation procedure to obtain in-situ applied stress values from post irradiation in-furnace force measurements is also presented.« less

Reduction of oxygen concentration by heater design during Czochralski Si growth

NASA Astrophysics Data System (ADS)

Zhou, Bing; Chen, Wenliang; Li, Zhihui; Yue, Ruicun; Liu, Guowei; Huang, Xinming

2018-02-01

Oxygen is one of the highest-concentration impurities in single crystals grown by the Czochralski (CZ) process, and seriously impairs the quality of the Si wafer. In this study, computer simulations were applied to design a new CZ system. A more appropriate thermal field was acquired by optimization of the heater structure. The simulation results showed that, compared with the conventional system, the oxygen concentration in the newly designed CZ system was reduced significantly throughout the entire CZ process because of the lower crucible wall temperature and optimized convection. To verify the simulation results, experiments were conducted on an industrial single-crystal furnace. The experimental results showed that the oxygen concentration was reduced significantly, especially at the top of the CZ-Si ingot. Specifically, the oxygen concentration was 6.19 × 1017 atom/cm3 at the top of the CZ-Si ingot with the newly designed CZ system, compared with 9.22 × 1017 atom/cm3 with the conventional system. Corresponding light-induced degradation of solar cells based on the top of crystals from the newly designed CZ system was 1.62%, a reduction of 0.64% compared with crystals from the conventional system (2.26%).

Prediction of stress corrosion of carbon steel by nuclear process liquid wastes

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ondrejcin, R.S.

1978-08-01

Radioactive liquid wastes are produced as a consequence of processing fuel from Savannah River Plant (SRP) production reactors. These wastes are stored in mild steel waste tanks, some of which have developed cracks from stress corrosion. A laboratory test was developed to determine the relative agressiveness of the wastes for stress corrosion cracking of mild steel. Tensile samples were strained to fracture in synthetic waste solutions in an electrochemical cell with the sample as the anode. Crack initiation is expected if total elongation of the steel in the test is less than its uniform elongation in air. Cracking would bemore » anticipated in a plant waste tank if solution conditions were equivalent to test conditions that cause a total elongation that is less than uniform elongation. The electrochemical tensile tests showed that the supernates in salt receiver tanks at SRP have the least aggressive compositions, and wastes newly generated during fuel repocessing have the most aggressive ones. Test data also verified that ASTM A 516-70 steel used in the fabrication of the later design waste tanks is less susceptible to cracking than the ASTM A 285-B steel used in earlier designs.« less

Multi-Reader ROC studies with Split-Plot Designs: A Comparison of Statistical Methods

PubMed Central

Obuchowski, Nancy A.; Gallas, Brandon D.; Hillis, Stephen L.

2012-01-01

Rationale and Objectives Multi-reader imaging trials often use a factorial design, where study patients undergo testing with all imaging modalities and readers interpret the results of all tests for all patients. A drawback of the design is the large number of interpretations required of each reader. Split-plot designs have been proposed as an alternative, in which one or a subset of readers interprets all images of a sample of patients, while other readers interpret the images of other samples of patients. In this paper we compare three methods of analysis for the split-plot design. Materials and Methods Three statistical methods are presented: Obuchowski-Rockette method modified for the split-plot design, a newly proposed marginal-mean ANOVA approach, and an extension of the three-sample U-statistic method. A simulation study using the Roe-Metz model was performed to compare the type I error rate, power and confidence interval coverage of the three test statistics. Results The type I error rates for all three methods are close to the nominal level but tend to be slightly conservative. The statistical power is nearly identical for the three methods. The coverage of 95% CIs fall close to the nominal coverage for small and large sample sizes. Conclusions The split-plot MRMC study design can be statistically efficient compared with the factorial design, reducing the number of interpretations required per reader. Three methods of analysis, shown to have nominal type I error rate, similar power, and nominal CI coverage, are available for this study design. PMID:23122570

Multi-reader ROC studies with split-plot designs: a comparison of statistical methods.

PubMed

Obuchowski, Nancy A; Gallas, Brandon D; Hillis, Stephen L

2012-12-01

Multireader imaging trials often use a factorial design, in which study patients undergo testing with all imaging modalities and readers interpret the results of all tests for all patients. A drawback of this design is the large number of interpretations required of each reader. Split-plot designs have been proposed as an alternative, in which one or a subset of readers interprets all images of a sample of patients, while other readers interpret the images of other samples of patients. In this paper, the authors compare three methods of analysis for the split-plot design. Three statistical methods are presented: the Obuchowski-Rockette method modified for the split-plot design, a newly proposed marginal-mean analysis-of-variance approach, and an extension of the three-sample U-statistic method. A simulation study using the Roe-Metz model was performed to compare the type I error rate, power, and confidence interval coverage of the three test statistics. The type I error rates for all three methods are close to the nominal level but tend to be slightly conservative. The statistical power is nearly identical for the three methods. The coverage of 95% confidence intervals falls close to the nominal coverage for small and large sample sizes. The split-plot multireader, multicase study design can be statistically efficient compared to the factorial design, reducing the number of interpretations required per reader. Three methods of analysis, shown to have nominal type I error rates, similar power, and nominal confidence interval coverage, are available for this study design. Copyright © 2012 AUR. All rights reserved.

Highly complex neutralization determinants on a monophyletic lineage of newly transmitted subtype C HIV-1 Env clones from India.

PubMed

Kulkarni, Smita S; Lapedes, Alan; Tang, Haili; Gnanakaran, S; Daniels, Marcus G; Zhang, Ming; Bhattacharya, Tanmoy; Li, Ming; Polonis, Victoria R; McCutchan, Francine E; Morris, Lynn; Ellenberger, Dennis; Butera, Salvatore T; Bollinger, Robert C; Korber, Bette T; Paranjape, Ramesh S; Montefiori, David C

2009-03-15

Little is known about the neutralization properties of HIV-1 in India to optimally design and test vaccines. For this reason, a functional Env clone was obtained from each of ten newly acquired, heterosexually transmitted HIV-1 infections in Pune, Maharashtra. These clones formed a phylogenetically distinct genetic lineage within subtype C. As Env-pseudotyped viruses the clones were mostly resistant to IgG1b12, 2G12 and 2F5 but all were sensitive to 4E10. When compared to a large multi-subtype panel of Env-pseudotyped viruses (subtypes B, C and CRF02_AG) in neutralization assays with a multi-subtype panel of HIV-1-positive plasma samples, the Indian Envs were remarkably complex. With the exception of the Indian Envs, results of a hierarchical clustering analysis showed a strong subtype association with the patterns of neutralization susceptibility. From these patterns we were able to identify 19 neutralization cluster-associated amino acid signatures in gp120 and 14 signatures in the ectodomain and cytoplasmic tail of gp41. We conclude that newly transmitted Indian Envs are antigenically complex in spite of close genetic similarity. Delineation of neutralization-associated amino acid signatures provides a deeper understanding of the antigenic structure of HIV-1 Env.

Caution and Warning Alarm Design and Evaluation for NASA CEV Auditory Displays: SHFE Information Presentation Directed Research Project (DRPP) report 12.07

NASA Technical Reports Server (NTRS)

Begault, Durand R.; Godfroy, Martine; Sandor, Aniko; Holden, Kritina

2008-01-01

The design of caution-warning signals for NASA s Crew Exploration Vehicle (CEV) and other future spacecraft will be based on both best practices based on current research and evaluation of current alarms. A design approach is presented based upon cross-disciplinary examination of psychoacoustic research, human factors experience, aerospace practices, and acoustical engineering requirements. A listening test with thirteen participants was performed involving ranking and grading of current and newly developed caution-warning stimuli under three conditions: (1) alarm levels adjusted for compliance with ISO 7731, "Danger signals for work places - Auditory Danger Signals", (2) alarm levels adjusted to an overall 15 dBA s/n ratio and (3) simulated codec low-pass filtering. Questionnaire data yielded useful insights regarding cognitive associations with the sounds.

Fabrication of bioinspired composite nanofiber membranes with robust superhydrophobicity for direct contact membrane distillation.

PubMed

Liao, Yuan; Wang, Rong; Fane, Anthony G

2014-06-03

The practical application of membrane distillation (MD) for water purification is hindered by the absence of desirable membranes that can fulfill the special requirements of the MD process. Compared to the membranes fabricated by other methods, nanofiber membranes produced by electrospinning are of great interest due to their high porosity, low tortuosity, large surface pore size, and high surface hydrophobicity. However, the stable performance of the nanofiber membranes in the MD process is still unsatisfactory. Inspired by the unique structure of the lotus leaf, this study aimed to develop a strategy to construct superhydrophobic composite nanofiber membranes with robust superhydrophobicity and high porosity suitable for use in MD. The newly developed membrane consists of a superhydrophobic silica-PVDF composite selective skin formed on a polyvinylidene fluoride (PVDF) porous nanofiber scaffold via electrospinning. This fabrication method could be easily scaled up due to its simple preparation procedures. The effects of silica diameter and concentration on membrane contact angle, sliding angle, and MD performance were investigated thoroughly. For the first time, the direct contact membrane distillation (DCMD) tests demonstrate that the newly developed membranes are able to present stable high performance over 50 h of testing time, and the superhydrophobic selective layer exhibits excellent durability in ultrasonic treatment and a continuous DCMD test. It is believed that this novel design strategy has great potential for MD membrane fabrication.

Association between molecular markers and behavioral phenotypes in the immatures of a butterfly.

PubMed

De Nardin, Janaína; Buffon, Vanessa; Revers, Luís Fernando; de Araújo, Aldo Mellender

2018-01-01

Newly hatched caterpillars of the butterfly Heliconius erato phyllis routinely cannibalize eggs. In a manifestation of kin recognition they cannibalize sibling eggs less frequently than unrelated eggs. Previous work has estimated the heritability of kin recognition in H. erato phyllis to lie between 14 and 48%. It has furthermore been shown that the inheritance of kin recognition is compatible with a quantitative model with a threshold. Here we present the results of a preliminary study, in which we tested for associations between behavioral kin recognition phenotypes and AFLP and SSR markers. We implemented two experimental approaches: (1) a cannibalism test using sibling eggs only, which allowed for only two behavioral outcomes (cannibal and non-cannibal), and (2) a cannibalism test using two sibling eggs and one unrelated egg, which allowed four outcomes [cannibal who does not recognize siblings, cannibal who recognizes siblings, "super-cannibal" (cannibal of both eggs), and "super non-cannibal" (does not cannibalize eggs at all)]. Single-marker analyses were performed using χ2 tests and logistic regression with null markers as covariates. Results of the χ2 tests identified 72 associations for experimental design 1 and 73 associations for design 2. Logistic regression analysis of the markers found to be significant in the χ2 test resulted in 20 associations for design 1 and 11 associations for design 2. Experiment 2 identified markers that were more frequently present or absent in cannibals who recognize siblings and super non-cannibals; i.e. in both phenotypes capable of kin recognition.

Association between molecular markers and behavioral phenotypes in the immatures of a butterfly

PubMed Central

De Nardin, Janaína; Buffon, Vanessa; Revers, Luís Fernando; de Araújo, Aldo Mellender

2018-01-01

Abstract Newly hatched caterpillars of the butterfly Heliconius erato phyllis routinely cannibalize eggs. In a manifestation of kin recognition they cannibalize sibling eggs less frequently than unrelated eggs. Previous work has estimated the heritability of kin recognition in H. erato phyllis to lie between 14 and 48%. It has furthermore been shown that the inheritance of kin recognition is compatible with a quantitative model with a threshold. Here we present the results of a preliminary study, in which we tested for associations between behavioral kin recognition phenotypes and AFLP and SSR markers. We implemented two experimental approaches: (1) a cannibalism test using sibling eggs only, which allowed for only two behavioral outcomes (cannibal and non-cannibal), and (2) a cannibalism test using two sibling eggs and one unrelated egg, which allowed four outcomes [cannibal who does not recognize siblings, cannibal who recognizes siblings, “super-cannibal” (cannibal of both eggs), and “super non-cannibal” (does not cannibalize eggs at all)]. Single-marker analyses were performed using χ2 tests and logistic regression with null markers as covariates. Results of the χ2 tests identified 72 associations for experimental design 1 and 73 associations for design 2. Logistic regression analysis of the markers found to be significant in the χ2 test resulted in 20 associations for design 1 and 11 associations for design 2. Experiment 2 identified markers that were more frequently present or absent in cannibals who recognize siblings and super non-cannibals; i.e. in both phenotypes capable of kin recognition. PMID:29583155

Spartan service module finite element modeling technique and analysis

NASA Technical Reports Server (NTRS)

Lindenmoyer, A. J.

1985-01-01

Sounding rockets have served as a relatively inexpensive and easy method of carrying experiments into the upper atmosphere. Limited observation time and pointing capabilities suggested the development of a new sounding rocket type carrier compatible with NASA's Space Transportation System. This concept evolved into the Spartan program, now credited with a successful Spartan 101 mission launched in June 1985. The next series of Spartans will use a service module primary structure. This newly designed reusable and universal component in the Spartan carrier system required thorough analysis and evaluation for flight certification. Using advanced finite element modeling techniques, the structure was analyzed and determined acceptable by meeting strict design goals and will be tested for verification of the analytical results.

"Turn laterally to the left!". The need for uniform C-arm communication terminology during orthopaedic trauma surgery.

PubMed

De Muinck Keizer, R-J; Klei, D S; Van Koperen, P J; Van Dijk, C N; Goslings, J C

2017-03-01

To avoid disturbed teamwork, unnecessary radiation exposure, and procedural delays, we designed and tested a uniform communication language for use in fluoroscopy-assisted surgical procedures. Input of surgeons and radiographers was used to create a set of commands. The potential benefit of this terminology was explored in an experimental setting. There was a tremendous diversity in the currently used terminology. Use of the newly designed terminology showed a reduction of procedural time and amount of images needed. Our first standardized Dutch language terminology can reduce total fluoroscopy time, number of images acquired, and potentially radiation exposure. For Dutch speaking colleagues, the developed terminology is freely available for use in their OR.

Identifying newly acquired cases of hepatitis C using surveillance: a literature review.

PubMed

Sacks-Davis, R; VAN Gemert, C; Bergeri, I; Stoove, M; Hellard, M

2012-11-01

Surveillance of newly acquired hepatitis C virus (HCV) infection is crucial for understanding the epidemiology of HCV and informing public health practice. However, monitoring such infections via surveillance systems is challenging because they are commonly asymptomatic. A literature review was conducted to identify methodologies used by HCV surveillance systems to identify newly acquired infections; relevant surveillance systems in 15 countries were identified. Surveillance systems used three main strategies to identify newly acquired infections: (1) asking physicians to classify cases; (2) identifying symptomatic cases or cases with elevated alanine aminotransferases; and (3) identifying cases with documented evidence of anti-HCV antibody seroconversion within a specific time-frame. Case-ascertainment methods varied with greater completeness of data in enhanced compared to passive surveillance systems. Automated systems that extract and link testing data from multiple laboratory and clinic databases may provide an opportunity for collecting testing histories for individuals that is less resource intensive than enhanced surveillance.

Simultaneous quantification of Myelin Basic Protein and Tau proteins in cerebrospinal fluid and serum of Multiple Sclerosis patients using nanoimmunosensor.

PubMed

Derkus, Burak; Acar Bozkurt, Pinar; Tulu, Metin; Emregul, Kaan C; Yucesan, Canan; Emregul, Emel

2017-03-15

This study was aimed at the development of an immunosensor for the simultaneous quantification of Myelin Basic Protein (MBP) and Tau proteins in cerebrospinal fluid (CSF) and serum, obtained from Multiple Sclerosis (MS) patients. The newly developed GO/pPG/anti-MBP/anti-Tau nanoimmunosensor has been established by immobilization of MBP and Tau antibodies. The newly developed nanoimmunosensor was tested, optimized and characterized using differential pulse voltammetry (DPV) and electrochemical impedance spectroscopy (EIS). The developed nanoimmunosensor was seen to have detection limits of 0.30nM for MBP and 0.15nM for Tau proteins which were sufficient for the levels to be analysed in neuro-clinic. The clinical study performed using CSF and serum of MS patients showed that the designed nanoimmunosensor was capable of detecting the proteins properly, that were essentially proven by ELISA. Copyright © 2016 Elsevier B.V. All rights reserved.

The Conceptual Design for a Fuel Assembly of a New Research Reactor

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ryu, J-S.; Cho, Y-G.; Yoon, D-B.

2004-10-06

A new Research Reactor (ARR) has been under design by KAERI since 2002. In this work, as a first step for the design of the fuel assembly of the ARR, the conceptual design has been carried out. The vibration characteristics of the tubular fuel model and the locking performance of the preliminary designed locking devices were investigated. In order to investigate the effects of the stiffener on the vibration characteristics of the tubular fuel, a modal analysis was performed for the finite element models of the tubular fuels with stiffeners and without stiffeners. The analysis results show that the vibrationmore » characteristics of the tubular fuel with stiffeners are better than those of the tubular fuel without stiffeners. To investigate the locking performance of the preliminary designed locking devices for the fuel assembly of the ARR, the elements of the locking devices were fabricated. Then the torsional resistance, fixing status and vibration characteristics of the locking devices were tested. The test results show that using the locking device with fins on the bottom guide can prevent the torsional motion of the fuel assembly, and that additional springs or guides on the top of the fuel assembly are needed to suppress the lateral motion of the fuel assembly. Based on the modal analysis and experimental results, the fuel assembly and locking devices of the ARR were designed and its prototype was fabricated. The locking performance, pressure drop characteristics and vibration characteristics of the newly designed fuel assembly will be tested in the near future.« less

The impact of transmission clusters on primary drug resistance in newly diagnosed HIV-1 infection.

PubMed

Yerly, Sabine; Junier, Thomas; Gayet-Ageron, Angèle; Amari, Emmanuelle Boffi El; von Wyl, Viktor; Günthard, Huldrych F; Hirschel, Bernard; Zdobnov, Evgeny; Kaiser, Laurent

2009-07-17

To monitor HIV-1 transmitted drug resistance (TDR) in a well defined urban area with large access to antiretroviral therapy and to assess the potential source of infection of newly diagnosed HIV individuals. All individuals resident in Geneva, Switzerland, with a newly diagnosed HIV infection between 2000 and 2008 were screened for HIV resistance. An infection was considered as recent when the positive test followed a negative screening test within less than 1 year. Phylogenetic analyses were performed by using the maximum likelihood method on pol sequences including 1058 individuals with chronic infection living in Geneva. Of 637 individuals with newly diagnosed HIV infection, 20% had a recent infection. Mutations associated with resistance to at least one drug class were detected in 8.5% [nucleoside reverse transcriptase inhibitors (NRTIs), 6.3%; non-nucleoside reverse transcriptase inhibitors (NNRTIs), 3.5%; protease inhibitors, 1.9%]. TDR (P-trend = 0.015) and, in particular, NNRTI resistance (P = 0.002) increased from 2000 to 2008. Phylogenetic analyses revealed that 34.9% of newly diagnosed individuals, and 52.7% of those with recent infection were linked to transmission clusters. Clusters were more frequent in individuals with TDR than in those with sensitive strains (59.3 vs. 32.6%, respectively; P < 0.0001). Moreover, 84% of newly diagnosed individuals with TDR were part of clusters composed of only newly diagnosed individuals. Reconstruction of the HIV transmission networks using phylogenetic analysis shows that newly diagnosed HIV infections are a significant source of onward transmission, particularly of resistant strains, thus suggesting an important self-fueling mechanism for TDR.

Procedures for Computing Transonic Flows for Control of Adaptive Wind Tunnels. Ph.D. Thesis - Technische Univ., Berlin, Mar. 1986

NASA Technical Reports Server (NTRS)

Rebstock, Rainer

1987-01-01

Numerical methods are developed for control of three dimensional adaptive test sections. The physical properties of the design problem occurring in the external field computation are analyzed, and a design procedure suited for solution of the problem is worked out. To do this, the desired wall shape is determined by stepwise modification of an initial contour. The necessary changes in geometry are determined with the aid of a panel procedure, or, with incident flow near the sonic range, with a transonic small perturbation (TSP) procedure. The designed wall shape, together with the wall deflections set during the tunnel run, are the input to a newly derived one-step formula which immediately yields the adapted wall contour. This is particularly important since the classical iterative adaptation scheme is shown to converge poorly for 3D flows. Experimental results obtained in the adaptive test section with eight flexible walls are presented to demonstrate the potential of the procedure. Finally, a method is described to minimize wall interference in 3D flows by adapting only the top and bottom wind tunnel walls.

In vitro prediction of gastrointestinal absorption of novel β-hydroxy-β-arylalkanoic acids using PAMPA technique.

PubMed

Savić, Jelena; Dobričić, Vladimir; Nikolic, Katarina; Vladimirov, Sote; Dilber, Sanda; Brborić, Jasmina

2017-03-30

Prediction of gastrointestinal absorption of thirteen newly synthesized β-hydroxy-β-arylalkanoic acids (HAA) and ibuprofen was performed using PAMPA test. The highest values of PAMPA parameters (%T and P app ) were calculated for 1C, 1B and 2C and these parameters were significantly lower in comparison to ibuprofen. QSPR analysis was performed in order to identify molecular descriptors with the highest influence on %T and -logP app and to create models which could be used for the design of novel HAA with improved gastrointestinal absorption. Obtained results indicate that introduction of branched side chain, as well as introduction of substituents on one phenyl ring (which disturb symmetry of the molecule) could have positive impact on gastrointestinal absorption. On the basis of these results, six novel HAA were designed and PAMPA parameters %T and -logP app were predicted by use of selected QSPR models. Designed derivatives should have better gastrointestinal absorption than HAA tested in this study. Copyright © 2017 Elsevier B.V. All rights reserved.

Design of an integrated fuel processor for residential PEMFCs applications

NASA Astrophysics Data System (ADS)

Seo, Yu Taek; Seo, Dong Joo; Jeong, Jin Hyeok; Yoon, Wang Lai

KIER has been developing a novel fuel processing system to provide hydrogen rich gas to residential PEMFCs system. For the effective design of a compact hydrogen production system, each unit process for steam reforming and water gas shift, has a steam generator and internal heat exchangers which are thermally and physically integrated into a single packaged hardware system. The newly designed fuel processor (prototype II) showed a thermal efficiency of 78% as a HHV basis with methane conversion of 89%. The preferential oxidation unit with two staged cascade reactors, reduces, the CO concentration to below 10 ppm without complicated temperature control hardware, which is the prerequisite CO limit for the PEMFC stack. After we achieve the initial performance of the fuel processor, partial load operation was carried out to test the performance and reliability of the fuel processor at various loads. The stability of the fuel processor was also demonstrated for three successive days with a stable composition of product gas and thermal efficiency. The CO concentration remained below 10 ppm during the test period and confirmed the stable performance of the two-stage PrOx reactors.

Newly learned word forms are abstract and integrated immediately after acquisition

PubMed Central

Kapnoula, Efthymia C.; McMurray, Bob

2015-01-01

A hotly debated question in word learning concerns the conditions under which newly learned words compete or interfere with familiar words during spoken word recognition. This has recently been described as a key marker of the integration of a new word into the lexicon and was thought to require consolidation Dumay & Gaskell, (Psychological Science, 18, 35–39, 2007; Gaskell & Dumay, Cognition, 89, 105–132, 2003). Recently, however, Kapnoula, Packard, Gupta, and McMurray, (Cognition, 134, 85–99, 2015) showed that interference can be observed immediately after a word is first learned, implying very rapid integration of new words into the lexicon. It is an open question whether these kinds of effects derive from episodic traces of novel words or from more abstract and lexicalized representations. Here we addressed this question by testing inhibition for newly learned words using training and test stimuli presented in different talker voices. During training, participants were exposed to a set of nonwords spoken by a female speaker. Immediately after training, we assessed the ability of the novel word forms to inhibit familiar words, using a variant of the visual world paradigm. Crucially, the test items were produced by a male speaker. An analysis of fixations showed that even with a change in voice, newly learned words interfered with the recognition of similar known words. These findings show that lexical competition effects from newly learned words spread across different talker voices, which suggests that newly learned words can be sufficiently lexicalized, and abstract with respect to talker voice, without consolidation. PMID:26202702

Apoptosis induction and anti-cancer activity of LeciPlex formulations.

PubMed

Dhawan, Vivek V; Joshi, Ganesh V; Jain, Ankitkumar S; Nikam, Yuvraj P; Gude, Rajiv P; Mulherkar, Rita; Nagarsenker, Mangal S

2014-10-01

Cationic agents have been reported to possess anti-neoplastic properties against various cancer cell types. However, their complexes with lipids appear to interact differently with different cancer cells. The purpose of this study was to (i) design and generate novel cationic lecithin nanoparticles, (ii) assess and understand the mechanism underlying their putative cytotoxicity and (iii) test their effect on cell cycle progression in various cancer-derived cell lines. In addition, we aimed to evaluate the in vivo potential of these newly developed nanoparticles in oral anti-cancer delivery. Cationic lecithin nanoparticles were generated using a single step nanoprecipitation method and they were characterized for particle size, zeta potential, stability and in vitro release. Their cytotoxic potential was assessed using a sulforhodamine B assay, and their effect on cell cycle progression was evaluated using flow cytometry. The nanoparticle systems were also tested in vivo for their anti-tumorigenic potential. In contrast to cationic agents alone, the newly developed nanoformulations showed a specific toxicity against cancer cells. The mechanism of toxic cell death included apoptosis, S and G2/M cell cycle phase arrest, depending on the type of cationic agent and the cancer-derived cell line used. Both blank and drug-loaded systems exhibited significant anti-cancer activity, suggesting a synergistic anti-tumorigenic effect of the drug and its delivery system. Both in vitro and in vivo data indicate that cationic agents themselves exhibit broad anti-neoplastic activities. Complex formation of the cationic agents with phospholipids was found to provide specificity to the anti-cancer activity. These formulations thus possess potential for the design of effective anti-cancer delivery systems.

Tooth-borne distraction osteogenesis versus conventional Le Fort I in maxillary advancement of cleft lip and palate patients.

PubMed

Jamilian, Abdolreza; Showkatbakhsh, Rahman; Behnaz, Mohammad; Ghassemi, Alireza; Kamalee, Zinat; Perillo, Letizia

2018-01-31

Distraction osteogenesis (DO) is rapidly becoming a mainstream surgical technique for correction of maxillary deficiency. The aim of this study was to compare the effectiveness of a newly designed tooth-borne osteogenic distraction device with conventional LeFort 1 osteotomy in maxillary advancement of cleft lip and palate patients. The DO group consisted of 10 subjects (7 males, 3 females) with a mean age of 21.2 (SD 4.2) years. In these patients, the newly designed distraction device which exerted force anteroposteriorly was cemented after mobilization of the maxilla. After a latency period of 7 days, the distractor was activated twice daily by a total amount of 0.5 mm per day. The activation was continued for 3 weeks. After an 8-week consolidation period, the distraction appliance was removed. Cephalograms of DO patients were obtained at the start of distraction and at the end of consolidation. The LeFort 1 group consisted of 11 subjects (6 males, 5 females) with a mean age of 22.3 (SD 3.7) years. Pre and post-surgery lateral cephalograms were obtained. T-Test and paired T-test were used to evaluate the data. At the end of treatment, the SNA angle of LeFort 1 patients increased by 5.5° (SD 2.3) (P<0.001) and the SNA angle of DO patients increased by 3.4° (SD 2) (P<0.001). Current evidence suggests that both conventional LeFort 1 and tooth-borne osteogenic distraction device can effectively advance the maxilla forward in patients with cleft lip.

The Cross-Correlation and Reshuffling Tests in Discerning Induced Seismicity

NASA Astrophysics Data System (ADS)

Schultz, Ryan; Telesca, Luciano

2018-05-01

In recent years, cases of newly emergent induced clusters have increased seismic hazard and risk in locations with social, environmental, and economic consequence. Thus, the need for a quantitative and robust means to discern induced seismicity has become a critical concern. This paper reviews a Matlab-based algorithm designed to quantify the statistical confidence between two time-series datasets. Similar to prior approaches, our method utilizes the cross-correlation to delineate the strength and lag of correlated signals. In addition, use of surrogate reshuffling tests allows for the dynamic testing against statistical confidence intervals of anticipated spurious correlations. We demonstrate the robust nature of our algorithm in a suite of synthetic tests to determine the limits of accurate signal detection in the presence of noise and sub-sampling. Overall, this routine has considerable merit in terms of delineating the strength of correlated signals, one of which includes the discernment of induced seismicity from natural.

A review of recent developments in flight test techniques at the Ames Research Center, Dryden Flight Research Facility

NASA Technical Reports Server (NTRS)

Layton, G. P.

1984-01-01

New flight test techniques in use at Ames Dryden are reviewed. The use of the pilot in combination with ground and airborne computational capabilities to maximize data return is discussed, including the remotely piloted research vehicle technique for high-risk testing, the remotely augmented vehicle technique for handling qualities research, and use of ground computed flight director information to fly unique profiles such as constant Reynolds number profiles through the transonic flight regime. Techniques used for checkout and design verification of systems-oriented aircraft are discussed, including descriptions of the various simulations, iron bird setups, and vehicle tests. Some newly developed techniques to support the aeronautical research disciplines are discussed, including a new approach to position-error determination, and the use of a large skin friction balance for the measurement of drag caused by various excrescencies.

Design of Mechanisms for Deployable, Optical Instruments: Guidelines for Reducing Hysteresis

NASA Technical Reports Server (NTRS)

Lake, Mark S.; Hachkowski, M. Roman

2000-01-01

This paper is intended to facilitate the development of deployable, optical instruments by providing a rational approach for the design, testing, and qualification of high-precision (i.e., low-hysteresis) deployment mechanisms for these instruments. Many of the guidelines included herein come directly from the field of optomechanical engineering, and are, therefore, neither newly developed guidelines, nor are they uniquely applicable to the design of high-precision deployment mechanisms. This paper is to be regarded as a guide to design and not a set of NASA requirements, except as may be defined in formal project specifications. Furthermore, due to the rapid pace of advancement in the field of precision deployment, this paper should be regarded as a preliminary set of guidelines. However, it is expected that this paper, with revisions as experience may indicate to be desirable, might eventually form the basis for a set of uniform design requirements for high-precision deployment mechanisms on future NASA space-based science instruments.

Accurate prediction of RNA-binding protein residues with two discriminative structural descriptors.

PubMed

Sun, Meijian; Wang, Xia; Zou, Chuanxin; He, Zenghui; Liu, Wei; Li, Honglin

2016-06-07

RNA-binding proteins participate in many important biological processes concerning RNA-mediated gene regulation, and several computational methods have been recently developed to predict the protein-RNA interactions of RNA-binding proteins. Newly developed discriminative descriptors will help to improve the prediction accuracy of these prediction methods and provide further meaningful information for researchers. In this work, we designed two structural features (residue electrostatic surface potential and triplet interface propensity) and according to the statistical and structural analysis of protein-RNA complexes, the two features were powerful for identifying RNA-binding protein residues. Using these two features and other excellent structure- and sequence-based features, a random forest classifier was constructed to predict RNA-binding residues. The area under the receiver operating characteristic curve (AUC) of five-fold cross-validation for our method on training set RBP195 was 0.900, and when applied to the test set RBP68, the prediction accuracy (ACC) was 0.868, and the F-score was 0.631. The good prediction performance of our method revealed that the two newly designed descriptors could be discriminative for inferring protein residues interacting with RNAs. To facilitate the use of our method, a web-server called RNAProSite, which implements the proposed method, was constructed and is freely available at http://lilab.ecust.edu.cn/NABind .

Value of laboratory tests in employer-sponsored health risk assessments for newly identifying health conditions: analysis of 52,270 participants.

PubMed

Kaufman, Harvey W; Williams, Fred R; Odeh, Mouneer A

2011-01-01

Employer-sponsored health risk assessments (HRA) may include laboratory tests to provide evidence of disease and disease risks for common medical conditions. We evaluated the ability of HRA-laboratory testing to provide new disease-risk information to participants. We performed a cross-sectional analysis of HRA-laboratory results for participating adult employees and their eligible spouses or their domestic partners, focusing on three common health conditions: hyperlipidemia, diabetes mellitus, and chronic kidney disease. HRA with laboratory results of 52,270 first-time participants were analyzed. Nearly all participants had access to health insurance coverage. Twenty-four percent (12,392) self-reported one or more of these medical conditions: 21.1% (11,017) self-identified as having hyperlipidemia, 4.7% (2,479) self-identified as having diabetes, and 0.7% (352) self-identified as having chronic kidney disease. Overall, 36% (n = 18,540) of participants had laboratory evidence of at least one medical condition newly identified: 30.7% (16,032) had laboratory evidence of hyperlipidemia identified, 1.9% (984) had laboratory evidence of diabetes identified, and 5.5% (2,866) had laboratory evidence of chronic kidney disease identified. Of all participants with evidence of hyperlipidemia 59% (16,030 of 27,047), were newly identified through the HRA. Among those with evidence of diabetes 28% (984 of 3,463) were newly identified. The highest rate of newly identified disease risk was for chronic kidney disease: 89% (2,866 of 3,218) of participants with evidence of this condition had not self-reported it. Men (39%) were more likely than women (33%) to have at least one newly identified condition (p<0.0001). Among men, lower levels of educational achievement were associated with modestly higher rates of newly identified disease risk (p<0.0001); the association with educational achievement among women was unclear. Even among the youngest age range (20 to 29 year olds), nearly 1 in 4 participants (24%) had a newly identified risk for disease. These results support the important role of employer-sponsored laboratory testing as an integral element of HRA for identifying evidence of previously undiagnosed common medical conditions in individuals of all working age ranges, regardless of educational level and gender.

Testing the newly installed PCE (Proximity Communications Equipment) hardware

NASA Image and Video Library

2005-06-29

ISS011-E-09816 (28 June 2005) --- Cosmonaut Sergei K. Krikalev, Expedition 11 commander representing Russia's Federal Space Agency, tests the newly installed Proximity Communications Equipment (PCE) hardware of the ASN-M satellite navigation system for the European Automated Transfer Vehicle (ATV) “Jules Verne” in the Zvezda Service Module of the International Space Station. The ATV is scheduled to arrive at the Station next year.

Testing the newly installed PCE (Proximity Communications Equipment) hardware

NASA Image and Video Library

2005-06-28

ISS011-E-09812 (28 June 2005) --- Cosmonaut Sergei K. Krikalev, Expedition 11 commander representing Russia's Federal Space Agency, tests the newly installed Proximity Communications Equipment (PCE) hardware of the ASN-M satellite navigation system for the European Automated Transfer Vehicle (ATV) “Jules Verne” in the Zvezda Service Module of the international space station. The ATV is scheduled to arrive at the station next year.

PONDS Watering System for Veggie

NASA Image and Video Library

2018-03-07

Tomato plants are growing inside a laboratory at the Space Station Processing Facility at NASA’s Kennedy Space Center in Florida. The plant growth is being tested in the Veggie Passive Orbital Nutrient Delivery System (PONDS). Veggie PONDS is a direct follow-on to the Veg-01 and Veg-03 hardware and plant growth validation tests. The primary goal of this newly developed plant growing system, Veggie PONDS, is to demonstrate uniform plant growth. PONDS units have features that are designed to mitigate microgravity effects on water distribution, increase oxygen exchange and provide sufficient room for root zone growth. PONDS is planned for use during Veg-04 and Veg-05 on the International Space Station after the Veggie PONDS Validation flights on SpaceX-14 and OA-9.

KSC-2009-6474

NASA Image and Video Library

2009-11-19

CAPE CANAVERAL, Fla. – This newly designed glove, one of the entries in the 2009 Astronaut Glove Challenge, undergoes a joint force test the 2009 Astronaut Glove Challenge, part of NASA’s Centennial Challenges Program, at the Astronaut Hall of Fame near NASA’s Kennedy Space Center in Florida. The nationwide competition focused on developing improved pressure suit gloves for astronauts to use while working in space. During the challenge, inventors tested the gloves to measure dexterity and strength during operation in a glove box which simulates the vacuum of space. Centennial Challenges is NASA’s program of technology prizes for the citizen-inventor. The winning prize for the Glove Challenge is $250,000 provided by the Centennial Challenges Program. Photo credit: NASA/Kim Shiflett

Results of Computer Based Training.

ERIC Educational Resources Information Center

1978

This report compares the projected savings of using computer based training to conduct training for newly hired pilots to the results of that application. New Hire training, one of a number of programs conducted continuously at the United Airline Flight Operations Training Center, is designed to assure that any newly hired pilot will be able to…

Molecular HIV screening.

PubMed

Bourlet, Thomas; Memmi, Meriam; Saoudin, Henia; Pozzetto, Bruno

2013-09-01

Nuclear acid testing is more and more used for the diagnosis of infectious diseases. This paper focuses on the use of molecular tools for HIV screening. The term 'screening' will be used under the meaning of first-line HIV molecular techniques performed on a routine basis, which excludes HIV molecular tests designed to confirm or infirm a newly discovered HIV-seropositive patient or other molecular tests performed for the follow-up of HIV-infected patients. The following items are developed successively: i) presentation of the variety of molecular tools used for molecular HIV screening, ii) use of HIV molecular tools for the screening of blood products, iii) use of HIV molecular tools for the screening of organs and tissue from human origin, iv) use of HIV molecular tools in medically assisted procreation and v) use of HIV molecular tools in neonates from HIV-infected mothers.

Pegasus delivers SLS engine section

NASA Image and Video Library

2017-03-03

NASA engineers install test hardware for the agency's new heavy lift rocket, the Space Launch System, into a newly constructed 50-foot structural test stand at NASA's Marshall Space Flight Center. In the stand, hydraulic cylinders will be electronically controlled to push, pull, twist and bend the test article with millions of pounds of force. Engineers will record and analyze over 3,000 channels of data for each test case to verify the capabilities of the engine section and validate that the design and analysis models accurately predict the amount of loads the core stage can withstand during launch and ascent. The engine section, recently delivered via NASA's barge Pegasus from NASA's Michoud Assembly Facility, is the first of four core stage structural test articles scheduled to be delivered to Marshall for testing. The engine section, located at the bottom of SLS's massive core stage, will house the rocket's four RS-25 engines and be an attachment point for the two solid rocket boosters.

Pegasus delivers SLS engine section

NASA Image and Video Library

2017-05-18

NASA engineers install test hardware for the agency's new heavy lift rocket, the Space Launch System, into a newly constructed 50-foot structural test stand at NASA's Marshall Space Flight Center. In the stand, hydraulic cylinders will be electronically controlled to push, pull, twist and bend the test article with millions of pounds of force. Engineers will record and analyze over 3,000 channels of data for each test case to verify the capabilities of the engine section and validate that the design and analysis models accurately predict the amount of loads the core stage can withstand during launch and ascent. The engine section, recently delivered via NASA's barge Pegasus from NASA's Michoud Assembly Facility, is the first of four core stage structural test articles scheduled to be delivered to Marshall for testing. The engine section, located at the bottom of SLS's massive core stage, will house the rocket's four RS-25 engines and be an attachment point for the two solid rocket boosters.

ARES I Upper Stage Subsystems Design and Development

NASA Technical Reports Server (NTRS)

Frate, David T.; Senick, Paul F.; Tolbert, Carol M.

2011-01-01

From 2005 through early 2011, NASA conducted concept definition, design, and development of the Ares I launch vehicle. The Ares I was conceived to serve as a crew launch vehicle for beyond-low-Earth-orbit human space exploration missions as part of the Constellation Program Architecture. The vehicle was configured with a single shuttle-derived solid rocket booster first stage and a new liquid oxygen/liquid hydrogen upper stage, propelled by a single, newly developed J-2X engine. The Orion Crew Exploration Vehicle was to be mated to the forward end of the Ares I upper stage through an interface with fairings and a payload adapter. The vehicle design passed a Preliminary Design Review in August 2008, and was nearing the Critical Design Review when efforts were concluded as a result of the Constellation Program s cancellation. At NASA Glenn Research Center, four subsystems were developed for the Ares I upper stage. These were thrust vector control (TVC) for the J-2X, electrical power system (EPS), purge and hazardous gas (P&HG), and development flight instrumentation (DFI). The teams working each of these subsystems achieved 80 percent or greater design completion and extensive development testing. These efforts were extremely successful representing state-of-the-art technology and hardware advances necessary to achieve Ares I reliability, safety, availability, and performance requirements. This paper documents the designs, development test activity, and results.

Porous materials with pre-designed single-molecule traps for CO2 selective adsorption

DOE Office of Scientific and Technical Information (OSTI.GOV)

Li, JR; Yu, JM; Lu, WG

2013-02-26

Despite tremendous efforts, precise control in the synthesis of porous materials with pre-designed pore properties for desired applications remains challenging. Newly emerged porous metal-organic materials, such as metal-organic polyhedra and metal-organic frameworks, are amenable to design and property tuning, enabling precise control of functionality by accurate design of structures at the molecular level. Here we propose and validate, both experimentally and computationally, a precisely designed cavity, termed a 'single-molecule trap', with the desired size and properties suitable for trapping target CO2 molecules. Such a single-molecule trap can strengthen CO2-host interactions without evoking chemical bonding, thus showing potential for CO2 capture.more » Molecular single-molecule traps in the form of metal-organic polyhedra are designed, synthesised and tested for selective adsorption of CO2 over N-2 and CH4, demonstrating the trapping effect. Building these pre-designed single-molecule traps into extended frameworks yields metal-organic frameworks with efficient mass transfer, whereas the CO2 selective adsorption nature of single-molecule traps is preserved.« less

Development of a turbojet engine gearbox test rig for prognostics and health management

NASA Astrophysics Data System (ADS)

Rezaei, Aida; Dadouche, Azzedine

2012-11-01

Aircraft engine gearboxes represent one of the many critical systems/elements that require special attention for longer and safer operation. Reactive maintenance strategies are unsuitable as they usually imply higher repair costs when compared to condition based maintenance. This paper discusses the main prognostics and health management (PHM) approaches, describes a newly designed gearbox experimental facility and analyses preliminary data for gear prognosis. The test rig is designed to provide full capabilities of performing controlled experiments suitable for developing a reliable diagnostic and prognostic system. The rig is based on the accessory gearbox of the GE J85 turbojet engine, which has been slightly modified and reconfigured to replicate real operating conditions such as speeds and loads. Defect to failure tests (DTFT) have been run to evaluate the performance of the rig as well as to assess prognostic metrics extracted from sensors installed on the gearbox casing (vibration and acoustic). The paper also details the main components of the rig and describes the various challenges encountered. Successful DTFT results were obtained during an idle engine performance test and prognostic metrics associated with the sensor suite were evaluated and discussed.

Characterization of the settling process for wastewater from a combined sewer system.

PubMed

Piro, P; Carbone, M; Penna, N; Marsalek, J

2011-12-15

Among the methods used for determining the parameters necessary for design of wastewater settling tanks, settling column tests are used most commonly, because of their simplicity and low costs. These tests partly mimic the actual settling processes and allow the evaluation of total suspended solids (TSS) removal by settling. Wastewater samples collected from the Liguori Channel (LC) catchment in Cosenza (Italy) were subject to settling column tests, which yielded iso-removal curves for both dry and wet-weather flow conditions. Such curves were approximated well by the newly proposed power law function containing two empirical parameters, a and b, the first of which is the particle settling velocity and the second one is a flocculation factor accounting for deviations from discrete particle settling. This power law function was tested for both the LC catchment and literature data and yielded a very good fit, with correlation coefficient values (R(2)) ranging from 0.93 to 0.99. Finally, variations in the settling tank TSS removal efficiencies with parameters a and b were also analyzed and provided insight for settling tank design. Copyright © 2011 Elsevier Ltd. All rights reserved.

Summary of the Manufacture, Testing and Model Validation of a Full-Scale Radiator for Fission Surface Power Applications

NASA Technical Reports Server (NTRS)

Ellis, David L.; Calder, James; Siamidis, John

2011-01-01

A full-scale radiator for a lunar fission surface power application was manufactured by Material innovations, Inc., for the NASA Glenn Research Center. The radiator was designed to reject 6 kWt with an inlet water temperature of 400 K and a water mass flow rate of 0.5 kg/s. While not flight hardware, the radiator incorporated many potential design features and manufacturing techniques for future flight hardware. The radiator was tested at NASA Glenn Research Center for heat rejection performance. The results showed that the radiator design was capable of rejecting over 6 kWt when operating at the design conditions. The actual performance of the radiator as a function of operational manifolds, inlet water temperature and facility sink temperature was compared to the predictive model developed by NASA Glenn Research Center. The results showed excellent agreement with the model with the actual average face sheet temperature being within 1% of the predicted value. The results will be used in the design and production of NASA s next generation fission power heat rejection systems. The NASA Glenn Research Center s Technology Demonstration Unit will be the first project to take advantage of the newly developed manufacturing techniques and analytical models.

Loss to Follow-Up from HIV Screening to ART Initiation in Rural China.

PubMed

Gu, Diane; Mao, Yurong; Tang, Zhenzhu; Montaner, Julio; Shen, Zhiyong; Zhu, Qiuying; Detels, Roger; Jin, Xia; Xiong, Ran; Xu, Juan; Ling, Walter; Erinoff, Lynda; Lindblad, Robert; Liu, David; Van Veldhuisen, Paul; Hasson, Albert; Wu, Zunyou

2016-01-01

Patients who are newly screened HIV positive by EIA are lost to follow-up due to complicated HIV testing procedures. Because this is the first step in care, it affects the entire continuum of care. This is a particular concern in rural China. To assess the routine HIV testing completeness and treatment initiation rates at 18 county-level general hospitals in rural Guangxi. We reviewed original hospital HIV screening records. Investigators also engaged with hospital leaders and key personnel involved in HIV prevention activities to characterize in detail the routine care practices in place at each county. 699 newly screened HIV-positive patients between January 1 and June 30, 2013 across the 18 hospitals were included in the study. The proportion of confirmatory testing across the 18 hospitals ranged from 14% to 87% (mean of 43%), and the proportion of newly diagnosed individuals successfully initiated antiretroviral treatment across the hospitals ranged from 3% to 67% (mean of 23%). The average interval within hospitals for individuals to receive the Western Blot (WB) and CD4 test results from HIV positive screening (i.e. achieving testing completion) ranged from 14-116 days (mean of 41.7 days) across the hospitals. The shortest interval from receiving a positive EIA screening test result to receiving WB and CD4 testing and counseling was 0 day and the longest was 260 days. The proportion of patients newly screened HIV positive that completed the necessary testing procedures for HIV confirmation and received ART was very low. Interventions are urgently needed to remove barriers so that HIV patients can have timely access to HIV/AIDS treatment and care in rural China.

Loss to Follow-Up from HIV Screening to ART Initiation in Rural China

PubMed Central

Gu, Diane; Mao, Yurong; Tang, Zhenzhu; Montaner, Julio; Shen, Zhiyong; Zhu, Qiuying; Detels, Roger; Jin, Xia; Xiong, Ran; Xu, Juan; Ling, Walter; Erinoff, Lynda; Lindblad, Robert; Liu, David; Van Veldhuisen, Paul; Hasson, Albert; Wu, Zunyou

2016-01-01

Background Patients who are newly screened HIV positive by EIA are lost to follow-up due to complicated HIV testing procedures. Because this is the first step in care, it affects the entire continuum of care. This is a particular concern in rural China. Objective(s) To assess the routine HIV testing completeness and treatment initiation rates at 18 county-level general hospitals in rural Guangxi. Methods We reviewed original hospital HIV screening records. Investigators also engaged with hospital leaders and key personnel involved in HIV prevention activities to characterize in detail the routine care practices in place at each county. Results 699 newly screened HIV-positive patients between January 1 and June 30, 2013 across the 18 hospitals were included in the study. The proportion of confirmatory testing across the 18 hospitals ranged from 14% to 87% (mean of 43%), and the proportion of newly diagnosed individuals successfully initiated antiretroviral treatment across the hospitals ranged from 3% to 67% (mean of 23%). The average interval within hospitals for individuals to receive the Western Blot (WB) and CD4 test results from HIV positive screening (i.e. achieving testing completion) ranged from 14–116 days (mean of 41.7 days) across the hospitals. The shortest interval from receiving a positive EIA screening test result to receiving WB and CD4 testing and counseling was 0 day and the longest was 260 days. Conclusion The proportion of patients newly screened HIV positive that completed the necessary testing procedures for HIV confirmation and received ART was very low. Interventions are urgently needed to remove barriers so that HIV patients can have timely access to HIV/AIDS treatment and care in rural China. PMID:27768710

Adolescents’ use of purpose built shade in secondary schools: cluster randomised controlled trial

PubMed Central

White, Vanessa; Wakefield, Melanie A; Jamsen, Kris M; White, Victoria; Livingston, Patricia M; English, Dallas R; Simpson, Julie A

2009-01-01

Objective To examine whether students use or avoid newly shaded areas created by shade sails installed at schools. Design Cluster randomised controlled trial with secondary schools as the unit of randomisation. Setting 51 secondary schools with limited available shade, in Australia, assessed over two spring and summer terms. Participants Students outside at lunch times. Intervention Purpose built shade sails were installed in winter 2005 at full sun study sites to increase available shade for students in the school grounds. Main outcome measure Mean number of students using the primary study sites during weekly observations at lunch time. Results Over the study period the mean change in students using the primary study site from pre-test to post-test was 2.63 (95% confidence interval 0.87 to 4.39) students in intervention schools and −0.03 (−1.16 to 1.09) students in control schools. The difference in mean change between groups was 2.67 (0.65 to 4.68) students (P=0.011). Conclusions Students used rather than avoided newly shaded areas provided by purpose built shade sails at secondary schools in this trial, suggesting a practical means of reducing adolescents’ exposure to ultraviolet radiation. Trial registration Exempt. PMID:19223344

The Metacarpal Locked Intramedullary Nail: Comparative Biomechanical Evaluation of New Implant Design for Metacarpal Fractures.

PubMed

Boonyasirikool, Chinnakart; Tanakeatsakul, Sakkarin; Niempoog, Sunyarn

2015-04-01

The optimal fixation of metacarpal fracture should provide sufficient stability to permit early functionfor all types of fracture. However; it must preserve surrounding soft tissue during application and not require secondary removal due to its prominence. The prototype of metacarpal locked intramedullary nail (MCLN) was designed by our institute aiming to achieve those allfeatures. To biomechanically test our newly designed, locked metacarpal nail and compare with common current available fixation methods. Thirty chicken humeri were devided into 3 groups (n = 1 per group) according tofixation techniques: MCLN, 1.5 mm miniplate (Synthes), and Kirschner wire. After complete fixation, all specimens were osteotomized at mid-shaft creating transverse fractures. Five specimens from each group were tested by load of failure under axial compression, and another five under bending force. In axial compression model, the loads tofailure in MCLN group was greatest (460 ± 17 N), which was significant higher than the Kirschner wire group. The MCLN group also showed the highest load to failure in bending test (341 ± 10 N). This value reaches statistical significance when compared with plate and Kirschner wire groups. The MCLN construct provided higher stability than miniplate and Kirschner wire fixation both in axial and bending mode. Together with the minimally invasive and soft tissue-friendly design concept, this study suggests that MCLN is promising fixation option for metacarpal fracture.

A newly developed tool for classifying study designs in systematic reviews of interventions and exposures showed substantial reliability and validity.

PubMed

Seo, Hyun-Ju; Kim, Soo Young; Lee, Yoon Jae; Jang, Bo-Hyoung; Park, Ji-Eun; Sheen, Seung-Soo; Hahn, Seo Kyung

2016-02-01

To develop a study Design Algorithm for Medical Literature on Intervention (DAMI) and test its interrater reliability, construct validity, and ease of use. We developed and then revised the DAMI to include detailed instructions. To test the DAMI's reliability, we used a purposive sample of 134 primary, mainly nonrandomized studies. We then compared the study designs as classified by the original authors and through the DAMI. Unweighted kappa statistics were computed to test interrater reliability and construct validity based on the level of agreement between the original and DAMI classifications. Assessment time was also recorded to evaluate ease of use. The DAMI includes 13 study designs, including experimental and observational studies of interventions and exposure. Both the interrater reliability (unweighted kappa = 0.67; 95% CI [0.64-0.75]) and construct validity (unweighted kappa = 0.63, 95% CI [0.52-0.67]) were substantial. Mean classification time using the DAMI was 4.08 ± 2.44 minutes (range, 0.51-10.92). The DAMI showed substantial interrater reliability and construct validity. Furthermore, given its ease of use, it could be used to accurately classify medical literature for systematic reviews of interventions although minimizing disagreement between authors of such reviews. Copyright © 2016 Elsevier Inc. All rights reserved.

MO-D-213-07: RadShield: Semi- Automated Calculation of Air Kerma Rate and Barrier Thickness

DOE Office of Scientific and Technical Information (OSTI.GOV)

DeLorenzo, M; Wu, D; Rutel, I

2015-06-15

Purpose: To develop the first Java-based semi-automated calculation program intended to aid professional radiation shielding design. Air-kerma rate and barrier thickness calculations are performed by implementing NCRP Report 147 formalism into a Graphical User Interface (GUI). The ultimate aim of this newly created software package is to reduce errors and improve radiographic and fluoroscopic room designs over manual approaches. Methods: Floor plans are first imported as images into the RadShield software program. These plans serve as templates for drawing barriers, occupied regions and x-ray tube locations. We have implemented sub-GUIs that allow the specification in regions and equipment for occupancymore » factors, design goals, number of patients, primary beam directions, source-to-patient distances and workload distributions. Once the user enters the above parameters, the program automatically calculates air-kerma rate at sampled points beyond all barriers. For each sample point, a corresponding minimum barrier thickness is calculated to meet the design goal. RadShield allows control over preshielding, sample point location and material types. Results: A functional GUI package was developed and tested. Examination of sample walls and source distributions yields a maximum percent difference of less than 0.1% between hand-calculated air-kerma rates and RadShield. Conclusion: The initial results demonstrated that RadShield calculates air-kerma rates and required barrier thicknesses with reliable accuracy and can be used to make radiation shielding design more efficient and accurate. This newly developed approach differs from conventional calculation methods in that it finds air-kerma rates and thickness requirements for many points outside the barriers, stores the information and selects the largest value needed to comply with NCRP Report 147 design goals. Floor plans, parameters, designs and reports can be saved and accessed later for modification and recalculation. We have confirmed that this software accurately calculates air-kerma rates and required barrier thicknesses for diagnostic radiography and fluoroscopic rooms.« less

A unified design space of synthetic stripe-forming networks

PubMed Central

Schaerli, Yolanda; Munteanu, Andreea; Gili, Magüi; Cotterell, James; Sharpe, James; Isalan, Mark

2014-01-01

Synthetic biology is a promising tool to study the function and properties of gene regulatory networks. Gene circuits with predefined behaviours have been successfully built and modelled, but largely on a case-by-case basis. Here we go beyond individual networks and explore both computationally and synthetically the design space of possible dynamical mechanisms for 3-node stripe-forming networks. First, we computationally test every possible 3-node network for stripe formation in a morphogen gradient. We discover four different dynamical mechanisms to form a stripe and identify the minimal network of each group. Next, with the help of newly established engineering criteria we build these four networks synthetically and show that they indeed operate with four fundamentally distinct mechanisms. Finally, this close match between theory and experiment allows us to infer and subsequently build a 2-node network that represents the archetype of the explored design space. PMID:25247316

Integration of Engine, Plume, and CFD Analyses in Conceptual Design of Low-Boom Supersonic Aircraft

NASA Technical Reports Server (NTRS)

Li, Wu; Campbell, Richard; Geiselhart, Karl; Shields, Elwood; Nayani, Sudheer; Shenoy, Rajiv

2009-01-01

This paper documents an integration of engine, plume, and computational fluid dynamics (CFD) analyses in the conceptual design of low-boom supersonic aircraft, using a variable fidelity approach. In particular, the Numerical Propulsion Simulation System (NPSS) is used for propulsion system cycle analysis and nacelle outer mold line definition, and a low-fidelity plume model is developed for plume shape prediction based on NPSS engine data and nacelle geometry. This model provides a capability for the conceptual design of low-boom supersonic aircraft that accounts for plume effects. Then a newly developed process for automated CFD analysis is presented for CFD-based plume and boom analyses of the conceptual geometry. Five test cases are used to demonstrate the integrated engine, plume, and CFD analysis process based on a variable fidelity approach, as well as the feasibility of the automated CFD plume and boom analysis capability.

Host-Guest Complexes with Protein-Ligand-Like Affinities: Computational Analysis and Design

PubMed Central

Moghaddam, Sarvin; Inoue, Yoshihisa

2009-01-01

It has recently been discovered that guests combining a nonpolar core with cationic substituents bind cucurbit[7]uril (CB[7]) in water with ultra-high affinities. The present study uses the Mining Minima algorithm to study the physics of these extraordinary associations and to computationally test a new series of CB[7] ligands designed to bind with similarly high affinity. The calculations reproduce key experimental observations regarding the affinities of ferrocene-based guests with CB[7] and β-cyclodextrin and provide a coherent view of the roles of electrostatics and configurational entropy as determinants of affinity in these systems. The newly designed series of compounds is based on a bicyclo[2.2.2]octane core, which is similar in size and polarity to the ferrocene core of the existing series. Mining Minima predicts that these new compounds will, like the ferrocenes, bind CB[7] with extremely high affinities. PMID:19133781

Contingency contracting with delinquents: effects of a brief training manual on staff contract negotiation and writing skills.

PubMed

Welch, S J; Holborn, S W

1988-01-01

A brief training manual was developed for the purpose of teaching child-care workers to contingency contract with delinquent youths living in residential care facilities. The manual was designed to require minimal supplementary training by a professional. In Experiment 1 a multiple baseline design was used to assess the effect of the manual on 4 child-care workers' contract negotiation and writing behaviors. Experiment 2 consisted of four A-B systematic replications. Behaviors were assessed within the context of analogue training simulations and generalization tests with delinquent youths. Results from the analogue simulations indicated that the manual was successful in increasing both types of behaviors to a level of proficiency that equaled or surpassed that of behaviorally trained graduate students, and results from the generalization tests indicated that the child-care workers were able to apply their newly acquired contracting skills with delinquent youths. Procedural reliability varied across child-care workers, but was usually high.

Low-Cost Control System Built Upon Consumer-Based Electronics For Supervisory Control Of A Gas-Operated Heat Pump

DOE Office of Scientific and Technical Information (OSTI.GOV)

Wetherington Jr, G Randall; Vineyard, Edward Allan; Mahderekal, Isaac

A preliminary evaluation of the performance of a consumer-based control system was conducted by the Oak Ridge National Laboratory (ORNL) and Southwest Gas as part of a cooperative research and development agreement (CRADA) authorized by the Department of Energy (DOE) (Mahderekal et al. (2013). The goal of the research was to evaluate the low-cost approach as a solution for implementing a supervisory control system for a residential gas-operated heat pump. The design incorporated two consumer-based micro-controllers; the Arduino Mega-2650 and the BeagleBone (white). Ten five-ton heat pump systems were designed, fabricated, and operationally tested in the Las Vega NV region.more » A robust data set was produced that allowed detailed assessment of the reliability and the operational perfromance of the newly developed control system. Experiences gained from the test provided important points of improvement for subsequent evolution of the heat pump technology.« less

Contingency contracting with delinquents: effects of a brief training manual on staff contract negotiation and writing skills.

PubMed Central

Welch, S J; Holborn, S W

1988-01-01

A brief training manual was developed for the purpose of teaching child-care workers to contingency contract with delinquent youths living in residential care facilities. The manual was designed to require minimal supplementary training by a professional. In Experiment 1 a multiple baseline design was used to assess the effect of the manual on 4 child-care workers' contract negotiation and writing behaviors. Experiment 2 consisted of four A-B systematic replications. Behaviors were assessed within the context of analogue training simulations and generalization tests with delinquent youths. Results from the analogue simulations indicated that the manual was successful in increasing both types of behaviors to a level of proficiency that equaled or surpassed that of behaviorally trained graduate students, and results from the generalization tests indicated that the child-care workers were able to apply their newly acquired contracting skills with delinquent youths. Procedural reliability varied across child-care workers, but was usually high. PMID:3225253

KSC-04PD-2683

NASA Technical Reports Server (NTRS)

2004-01-01

KENNEDY SPACE CENTER, FLA. Observers walk alongside the newly shod Crawler Transporter as it moves slowly forward. The Crawler Transporter that will move Space Shuttle Discovery to the launch pad for Return to Flight is taking its first road test following the replacement of all its shoes. The crawlers have 456 shoes, 57 per belt (8 belts in all). Each shoe weighs 2,200 pounds. Cracks appeared in the shoes in recent years, spurring a need for replacement. The new manufacturer, in Duluth, Minn., has improved the design for a safe Return to Flight and use through the balance of the Space Shuttle Program.

Experimental study and constitutive modeling of the viscoelastic mechanical properties of the human prolapsed vaginal tissue.

PubMed

Peña, Estefania; Calvo, B; Martínez, M A; Martins, P; Mascarenhas, T; Jorge, R M N; Ferreira, A; Doblaré, M

2010-02-01

In this paper, the viscoelastic mechanical properties of vaginal tissue are investigated. Using previous results of the authors on the mechanical properties of biological soft tissues and newly experimental data from uniaxial tension tests, a new model for the viscoelastic mechanical properties of the human vaginal tissue is proposed. The structural model seems to be sufficiently accurate to guarantee its application to prediction of reliable stress distributions, and is suitable for finite element computations. The obtained results may be helpful in the design of surgical procedures with autologous tissue or prostheses.

Reference values for fatigued versus non-fatigued limb symmetry index measured by a newly designed single-leg hop test battery in healthy subjects: a pilot study.

PubMed

Leister, Iris; Mattiassich, Georg; Kindermann, Harald; Ortmaier, Reinhold; Barthofer, Jürgen; Vasvary, Imre; Katzensteiner, Klaus; Stelzhammer, Christine; Kulnik, Stefan Tino

2018-01-01

There is sparse evidence for return to sport criteria after knee injury. Functional performance deficits, particularly in fatigued muscular condition, should be verified prior to the attempt to return to high-risk pivoting sports. The purpose of this study was to generate reference values for the limb symmetry index (LSI) of healthy subjects in fatigued and non-fatigued muscular condition in a newly designed test battery. Forty-two healthy subjects [22 females, 20 males; mean (SD) age 30.4 (6.6) years] were evaluated using a test battery consisting of an isometric strength test, a series of five single-leg hop tests and an integrated fatigue protocol. Subjective physical activity was assessed with the Tegner Activity Scale (TAS). The cut-off values for healthy subjects were calculated considering the fifth percentile as the minimum reference value for the LSI and single-leg hop distance. The mean (SD) overall LSI was 98.8% (4.6). No significant gender or age specific differences in limb symmetry were observed. The comparison of the non-fatigued LSI with the overall LSI revealed no clinically relevant change due to muscular fatigue. Repeated measures ANOVA revealed a significant within effect on fatigue/non-fatigue condition ( F (1,38)  = 18.000; p  < 0.001, η 2  = 0.321) on absolute single-leg hop distance. Moreover, a significant between effect on the TAS-parameter ( F (1,38)  = 5.928; p  = 0.020, η 2  = 0.135 between: TAS ≤ 5/TAS > 5) and on gender ( F (1,38)  = 23.956; p  < 0.001, η 2  = 0.387) could be detected. The absolute jumping distance in the single-leg hop for distance was significantly reduced due to fatigue. No clinically relevant effect of muscular fatigue was observed on limb symmetry in our study sample. Gender and physical activity are important factors to be considered when interpreting reference values.

Improved biomedical electrode

NASA Technical Reports Server (NTRS)

Frost, J. D., Jr.

1972-01-01

Newly designed electrode is prefilled, disposable, electrolyte-saturated spong. New design permits longe periods of storage without deterioration, and readiness in matter of seconds. Electrodes supply signals for electroencephalogram, electro-oculogram, and electrocardiogram.

A Probablistic Diagram to Guide Chemical Design with ...

EPA Pesticide Factsheets

Toxicity is a concern with many chemicals currently in commerce, and with new chemicals that are introduced each year. The standard approach to testing chemicals is to run studies in laboratory animals (e.g. rats, mice, dogs), but because of the expense of these studies and concerns for animal welfare, few chemicals besides pharmaceuticals and pesticides are fully tested. Over the last decade there have been significant developments in the field of computational toxicology which combines in vitro tests and computational models. The ultimate goal of this ?field is to test all chemicals in a rapid, cost effective manner with minimal use of animals. One of the simplest measures of toxicity is provided by high-throughput in vitro cytotoxicity assays, which measure the concentration of a chemical that kills particular types of cells. Chemicals that are cytotoxic at low concentrations tend to be more toxic to animals than chemicals that are less cytotoxic. We employed molecular characteristics derived from density functional theory (DFT) and predicted values of log(octanol-water partition coe?fficient) (logP)to construct a design variable space, and built a predictive model for cytotoxicity using a Naive Bayesian algorithm. External evaluation showed that the area under the curve (AUC) for the receiver operating characteristic (ROC) of the model to be 0.81. Using this model, we provide design rules to help synthetic chemists minimize the chance that a newly synthesize

A Behavioral Investigation of Preference in a Newly Designed New Zealand Playground

ERIC Educational Resources Information Center

Bourke, Tina M.; Sargisson, Rebecca J.

2014-01-01

Playgrounds with spaces that attract children increase the likelihood children will use them, the authors note, and playgrounds offer an opportunity for children to experience the risks of outdoor play. The authors used natural observation to study the children at play in a newly built New Zealand playground where such an important kind of…

Perceived Stress and Coping Strategies among Newly Nurse Students in Clinical Practice

ERIC Educational Resources Information Center

Mahfouz, Rasha; Alsahli, Haya

2016-01-01

The present study aimed at assessing the stress level and coping strategies among students who were newly in Practicing the clinical training in different hospitals, at the Nursing College, Princess Nourah University. The study design was a descriptive analytical one. The study was conducted at the beginning of second semester in the academic year…

Life Review: Preventing Despair in Newly Relocated Nursing Home Residents--Short- and Long-Term Effects.

ERIC Educational Resources Information Center

Haight, Barbara K.; Michel, Yvonne; Hendrix, Shirley

1998-01-01

Elders newly relocated to a nursing home (N=256) were followed for five years using a Solomon Four research design. Life review was shown to be more effective than a friendly visit for preventing despair and promoting integrity immediately and at one-year follow-up. Additional measures are discussed. (Author/EMK)

Timing of entry to care by newly diagnosed HIV cases before and after the 2010 New York State HIV testing law.

PubMed

Gordon, Daniel E; Bian, Fuqin; Anderson, Bridget J; Smith, Lou C

2015-01-01

Prompt entry to care after HIV diagnosis benefits the infected individual and reduces the likelihood of further transmission of the virus. The New York State HIV Testing Law of 2010 requires diagnosing providers to refer persons newly diagnosed with HIV to follow-up medical care. This study used routinely collected HIV-related laboratory data from the New York State HIV surveillance system to assess whether the fraction of newly diagnosed cases entering care within 90 days of diagnosis increased after the implementation of the law. Laboratory data on 23,302 newly diagnosed cases showed that entry to care within 90 days rose steadily from 72.0% in 2007 to 85.4% in 2012. The rise was observed across all race/ethnic groups, ages, transmission risk groups, sexes, and regions of residence. Logistic regression analyses of entry to care pre-law and post-law, controlling for demographic characteristics, transmission risk, and geographic area, indicate that percentage of newly diagnosed cases entering care within 90 days grew more rapidly in the post-law period. This is consistent with a positive effect of the law on entry to care.

Design and testing of temperature tunable de Laval nozzles for applications in gas-phase reaction kinetics

NASA Astrophysics Data System (ADS)

Canosa, A.; Ocaña, A. J.; Antiñolo, M.; Ballesteros, B.; Jiménez, E.; Albaladejo, J.

2016-09-01

A series of three de Laval nozzles initially designed to generate uniform supersonic flows in helium at 23 and 36 K and in argon at 50 K have been used with either pure nitrogen or mixtures of nitrogen with helium or argon in order to make a sequence of pulsed supersonic flows working at different temperatures. For this, a computer homemade program has been used to design de Laval nozzles contours for gas mixtures in order to determine the theoretical pressure P and temperature T in these supersonic flows. Spatial evolution of T along the flow axis downstream of the nozzle exit has been characterized with a fast response Pitot tube instrument newly developed. Twenty-eight different gas mixture conditions have been tested, indicating a very good agreement with the corresponding calculated flow conditions. The length of uniformity Δ L of the supersonic flows have been found to be >30 cm in more than 80 % of the situations and >50 cm for more than 50 % of the tested conditions. Fine temperature tunability was achieved in the range 22-107 K with very small fluctuations of the mean temperature along Δ L. Advantages and limits of these new developments for studies of gas-phase reaction kinetics are discussed.

The DESMEX Project - Deep Electromagnetic Sounding for Mineral EXploration

NASA Astrophysics Data System (ADS)

Meyer, U.; Becken, M.; Stolz, R.; Nittinger, C.; Cherevatova, M.; Siemon, B.; Martin, T.; Petersen, H.; Steuer, A.

2017-12-01

The DESMEX project (Deep Electromagnetic Sounding for Mineral Exploration) aims to develop independent semi-airborne frequency domain systems for mineral exploration down to depths of 1 km and deeper. Two different helicopter-towed systems are being designed and tested using source installations on ground. One system uses among other equipment conventional three axis induction coils, a 3D-fluxgate and a high precision inertial motion unit. The use of the two different magnetometers allows to record data in a broad frequency range from 1 Hz to 10 kHz. The second system uses a newly developed SQUID-based sensing system of a similar frequency range and a self made inertial motion unit. Horizontal electric dipole transmitters provided by the Leibniz Institute for Applied Geophysics in Hannover and the Institute of Geophysics and Meteorology of the University in Cologne are used as ground based sources. First system tests showed a good performance of both systems with general noise levels below 50 pT/root(Hz). Test flights above the common survey area proved that the desired depth of investigation can be achieved and that the data is consistent with the subsurface conductivity structures. In order to verify the data acquired from the newly developed system at shallow depths and to provide a better starting model for later inversion calculations helicopter borne frequency domain electromagnetics has been acquired and fully processed over the test site Schleiz - Greiz in Germany. To further relate the subsurface conductivity models to the subsurface geology and mineralogy, petrophysical investigations have been performed on rock samples from the site of investigation and analogue samples.

Provision of test results and posttest counseling at STD clinics in 24 health departments: U.S., 2007.

PubMed

Begley, Elin; VanHandel, Michelle

2012-01-01

We determined the demographic and HIV test characteristics of tests conducted in CDC-funded sexually transmitted disease (STD) clinics with provision of test results and posttest counseling. We used CDC's HIV Counseling and Testing System data from 2007 for the 24 U.S. health departments that reported test-level data from STD clinics. We calculated and analyzed newly identified HIV positivity and the percentage of tests with provision of test results and posttest counseling (provision of posttest counseling), by demographic and HIV-related characteristics. Of 372,757 tests conducted among people without a previous HIV diagnosis by self-report, provision of posttest counseling was documented for 191,582 (51.4%) HIV tests overall and 1,922 (71.2%) newly identified HIV-positive test results. At these STD clinics, provision of posttest counseling varied by HIV serostatus, age, race/ethnicity, test type, and risk category; however, documentation of posttest counseling was missing for more than 20% of tests. The newly identified HIV positivity among all testers was 0.7%. One of the main goals of HIV counseling and testing is to inform people of their HIV status, because knowledge of one's HIV-positive serostatus can result in a reduction in risk behaviors and allow the person to access HIV medical care and treatment. STD clinics offering HIV testing may need to further their emphasis on increasing the proportion of clients who are provided posttest counseling and on improving documentation of this information.

Hydraulic analysis and optimization design in Guri rehabilitation project

NASA Astrophysics Data System (ADS)

Cheng, H.; Zhou, L. J.; Gong, L.; Wang, Z. N.; Wen, Q.; Zhao, Y. Z.; Wang, Y. L.

2016-11-01

Recently Dongfang was awarded the contract for rehabilitation of 6 units in Guri power plant, the biggest hydro power project in Venezuela. The rehabilitation includes, but not limited to, the extension of output capacity by about 50% and enhancement of efficiency level. To achieve the targets the runner and the guide vanes will be replaced by the newly optimized designs. In addition, the out-of-date stay vanes with straight plate shape will be modified into proper profiles after considering the application feasibility in field. The runner and vane profiles were optimized by using state-of-the-art flow simulation techniques. And the hydraulic performances were confirmed by the following model tests. This paper describes the flow analysis during the optimization procedure and the comparison between various technical concepts.

Development of a non-explosive release actuator using shape memory alloy wire.

PubMed

Yoo, Young Ik; Jeong, Ju Won; Lim, Jae Hyuk; Kim, Kyung-Won; Hwang, Do-Soon; Lee, Jung Ju

2013-01-01

We have developed a newly designed non-explosive release actuator that can replace currently used release devices. The release mechanism is based on a separation mechanism, which relies on segmented nuts and a shape memory alloy (SMA) wire trigger. A quite fast and simple trigger operation is made possible through the use of SMA wire. This actuator is designed to allow a high preload with low levels of shock for the solar arrays of medium-size satellites. After actuation, the proposed device can be easily and instantly reset. Neither replacement, nor refurbishment of any components is necessary. According to the results of a performance test, the release time, preload capacity, and maximum shock level are 50 ms, 15 kN, and 350 G, respectively. In order to increase the reliability of the actuator, more than ten sets of performance tests are conducted. In addition, the proposed release actuator is tested under thermal vacuum and extreme vibration environments. No degradation or damage was observed during the two environment tests, and the release actuator was able to operate successfully. Considering the test results as a whole, we conclude that the proposed non-explosive release actuator can be applied reliably to intermediate-size satellites to replace existing release systems.

Age-related Decline of Abiotic Stress Tolerance in Young Drosophila melanogaster Adults.

PubMed

Colinet, Hervé; Chertemps, Thomas; Boulogne, Isabelle; Siaussat, David

2016-12-01

Stress tolerance generally declines with age as a result of functional senescence. Age-dependent alteration of stress tolerance can also occur in early adult life. In Drosophila melanogaster, evidence of such a decline in young adults has only been reported for thermotolerance. It is not known whether early adult life entails a general stress tolerance reduction and whether the response is peculiar to thermal traits. The present work was designed to investigate whether newly eclosed D melanogaster adults present a high tolerance to a range of biotic and abiotic insults. We found that tolerance to most of the abiotic stressors tested (desiccation, paraquat, hydrogen peroxide, deltamethrin, and malathion) was high in newly eclosed adults before dramatically declining over the next days of adult life. No clear age-related pattern was found for resistance to biotic stress (septic or fungal infection) and starvation. These results suggest that newly eclosed adults present a culminating level of tolerance to extrinsic stress which is likely unrelated to immune process. We argue that stress tolerance variation at very young age is likely a residual attribute from the previous life stage (ontogenetic carryover) or a feature related to the posteclosion development. © The Author 2015. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Advantages of using newly developed quartz contact lens with slit illumination from operating microscope.

PubMed

Kiyokawa, Masatoshi; Sakuma, Toshiro; Hatano, Noriko; Mizota, Atsushi; Tanaka, Minoru

2009-06-01

The purpose of this article is to report the characteristics and advantages of using a newly designed quartz contact lens with slit illumination from an operating microscope for intraocular surgery. The new contact lens is made of quartz. The lens is convex-concave and is used in combination with slit illumination from an operating microscope. The optical properties of quartz make this lens less reflective with greater transmittance. The combination of a quartz contact lens with slit illumination provided a brighter and wider field of view than conventional lenses. This system enabled us to perform bimanual vitrectomy and scleral buckling surgery without indirect ophthalmoscope. Small intraocular structures in the posterior pole or in the periphery were detected more easily. In conclusion, the newly designed quartz lens with slit beam illumination from an operating microscope provided a bright, clear and wide surgical field, and allowed intraocular surgery to be performed more easily.

Design of a new engine mount for vertical and horizontal vibration control using magnetorheological fluid

NASA Astrophysics Data System (ADS)

Phu, D. X.; Choi, S. B.; Lee, Y. S.; Han, M. S.

2014-10-01

This paper presents a new design of a magnetorheological fluid (MR) mount for vibration control considering both vertical forces and horizontal moments such as are met in various engine systems, including a medium high-speed engine of ship. The newly designed mount, called a MR brake mount, offers several salient benefits such as small size and relatively high load capacity compared with a conventional MR engine mount that can control vertical vibration only. The principal design parameters of the proposed mount are optimally determined to achieve maximum torque with geometric and spatial constraints. Subsequently, the proposed MR mount is designed and manufactured based on the optimized design parameters. It is shown from experimental testing that the proposed mount, which combines MR mount with MR brake, can produce the desired force and torque to reduce unwanted vibration of a medium high-speed engine system of ship subjected to both vertical and horizontal exciting motions. In addition, it is verified that there is no large difference between experiment results and simulation results that are obtained from an analytical model derived in this work.

Design and damping force characterization of a new magnetorheological damper activated by permanent magnet flux dispersion

NASA Astrophysics Data System (ADS)

Lee, Tae-Hoon; Han, Chulhee; Choi, Seung-Bok

2018-01-01

This work proposes a novel type of tunable magnetorheological (MR) damper operated based solely on the location of a permanent magnet incorporated into the piston. To create a larger damping force variation in comparison with the previous model, a different design configuration of the permanent-magnet-based MR (PMMR) damper is introduced to provide magnetic flux dispersion in two magnetic circuits by utilizing two materials with different magnetic reluctance. After discussing the design configuration and some advantages of the newly designed mechanism, the magnetic dispersion principle is analyzed through both the formulated analytical model of the magnetic circuit and the computer simulation based on the magnetic finite element method. Sequentially, the principal design parameters of the damper are determined and fabricated. Then, experiments are conducted to evaluate the variation in damping force depending on the location of the magnet. It is demonstrated that the new design and magnetic dispersion concept are valid showing higher damping force than the previous model. In addition, a curved structure of the two materials is further fabricated and tested to realize the linearity of the damping force variation.

Optimization of an idealized Y-Shaped Extracardiac Fontan Baffle

NASA Astrophysics Data System (ADS)

Yang, Weiguang; Feinstein, Jeffrey; Mohan Reddy, V.; Marsden, Alison

2008-11-01

Research has showed that vascular geometries can significantly impact hemodynamic performance, particularly in pediatric cardiology, where anatomy varies from one patient to another. In this study we optimize a newly proposed design for the Fontan procedure, a surgery used to treat single ventricle heart patients. The current Fontan procedure connects the inferior vena cava (IVC) to the pulmonary arteries (PA's) via a straight Gore-Tex tube, forming a T-shaped junction. In the Y-graft design, the IVC is connected to the left and right PAs by two branches. Initial studies on the Y-graft design showed an increase in efficiency and improvement in flow distribution compared to traditional designs in a single patient-specific model. We now optimize an idealized Y-graft model to refine the design prior to patient testing. A derivate-free optimization algorithm using Kriging surrogate functions and mesh adaptive direct search is coupled to a 3-D finite element Navier-Stokes solver. We will present optimization results for rest and exercise conditions and examine the influence of energy efficiency, wall shear stress, pulsatile flow, and flow distribution on the optimal design.

Travel-associated acquisition of hepatitis C virus infection in patients receiving haemodialysis.

PubMed

Ghafur, Abdul; Raza, Muhammad; Labbett, Wendy; Chawla, Anuradha; Smith, Colette; Ngui, Siew Lin; Davenport, Andrew; Geretti, Anna Maria

2007-09-01

It has been proposed that hepatitis C virus (HCV)-infected patients with end-stage renal disease undergoing maintenance haemodialysis may lack HCV antibody (anti-HCV) despite chronic HCV viraemia. This carries important implications for the design of surveillance policies. To characterize the prevalence of antibody-negative/RNA-positive HCV infection, patients attending seven haemodialysis units underwent anti-HCV testing using a third-generation assay and HCV RNA testing using real-time PCR. At screening, anti-HCV prevalence was 12/360 (3.3%; 95% CI 1.7-5.8%); 7/12 (58.3%) anti-HCV positive samples were HCV RNA positive. Among anti-HCV-negative samples, 2/348 (0.6%; 95% CI 0.2-2.1%) tested HCV RNA positive (genotype 1a). Retrospective testing of stored sera dated the infections to a period of holiday in the Indian subcontinent. The two infections were unrelated by HCV-NS5B sequencing. Only one of the two newly infected persons showed raised transaminases. Both developed anti-HCV within 8-13 weeks of follow-up. Prospective surveillance of travellers to resource-limited countries returning to the units showed a HCV incidence of 4/153 travel episodes (2.6%; 95% CI 0.7-6.6%) among 131 persons (3.1%; 95% CI 0.8-7.6%). Among haemodialysis patients in the United Kingdom, antibody-negative/RNA-positive HCV status is associated with newly acquired infection, rather than lack of antibody responses in chronic HCV infection. There is a significant risk of HCV infection associated with travel to resource-limited countries. Given that transaminase levels may be normal, HCV RNA testing is recommended in patients re-entering a dialysis unit following haemodialysis in settings where suboptimal infection control policies pose a risk of exposure to blood-borne viruses.

Air cleaning performance of a new environmentally controlled primary crusher operator booth.

PubMed

Organiscak, J A; Cecala, A B; Zimmer, J A; Holen, B; Baregi, J R

2016-02-01

The National Institute for Occupational Safety and Health (NIOSH) cooperated with 3M Company in the design and testing of a new environmentally controlled primary crusher operator booth at the company's Wausau granite quarry near Wausau, WI. This quarry had an older crusher booth without a central heating, ventilation and air conditioning (HVAC) system, and without an air filtration and pressurization system. A new replacement operator booth was designed and installed by 3M based on design considerations from past NIOSH research on enclosed cab filtration systems. NIOSH conducted pre-testing of the old booth and post-testing of the new booth to assess the new filtration and pressurization system's effectiveness in controlling airborne dusts and particulates. The booth's dust and particulate control effectiveness is described by its protection factor, expressed as a ratio of the outside to inside concentrations measured during testing. Results indicate that the old booth provided negligible airborne respirable dust protection and low particulate protection from the outside environment. The newly installed booth provided average respirable dust protection factors from 2 to 25 over five shifts of dust sampling with occasional worker ingress and egress from the booth, allowing some unfiltered contaminants to enter the enclosure. Shorter-term particle count testing outside and inside the booth under near-steady-state conditions, with no workers entering or exiting the booth, resulted in protection factors from 35 to 127 on 0.3- to 1.0-μm respirable size particulates under various HVAC airflow operating conditions.

Design of a high-speed electrochemical scanning tunneling microscope.

PubMed

Yanson, Y I; Schenkel, F; Rost, M J

2013-02-01

In this paper, we present a bottom-up approach to designing and constructing a high-speed electrochemical scanning tunneling microscope (EC-STM). Using finite element analysis (FEA) calculations of the frequency response of the whole mechanical loop of the STM, we analyzed several geometries to find the most stable one that could facilitate fast scanning. To test the FEA results, we conducted measurements of the vibration amplitudes using a prototype STM setup. Based on the FEA analysis and the measurement results, we identified the potentially most disturbing vibration modes that could impair fast scanning. By modifying the design of some parts of the EC-STM, we reduced the amplitudes as well as increased the resonance frequencies of these modes. Additionally, we designed and constructed an electrochemical flow-cell that allows STM imaging in a flowing electrolyte, and built a bi-potentiostat to achieve electrochemical potential control during the measurements. Finally, we present STM images acquired during high-speed imaging in air as well as in an electrochemical environment using our newly-developed EC-STM.

Estimation of the Percentage of Newly Diagnosed HIV-Positive Persons Linked to HIV Medical Care in CDC-Funded HIV Testing Programs.

PubMed

Wang, Guoshen; Pan, Yi; Seth, Puja; Song, Ruiguang; Belcher, Lisa

2017-01-01

Missing data create challenges for determining progress made in linking HIV-positive persons to HIV medical care. Statistical methods are not used to address missing program data on linkage. In 2014, 61 health department jurisdictions were funded by Centers for Disease Control and Prevention (CDC) and submitted data on HIV testing, newly diagnosed HIV-positive persons, and linkage to HIV medical care. Missing or unusable data existed in our data set. A new approach using multiple imputation to address missing linkage data was proposed, and results were compared to the current approach that uses data with complete information. There were 12,472 newly diagnosed HIV-positive persons from CDC-funded HIV testing events in 2014. Using multiple imputation, 94.1% (95% confidence interval (CI): [93.7%, 94.6%]) of newly diagnosed persons were referred to HIV medical care, 88.6% (95% CI: [88.0%, 89.1%]) were linked to care within any time frame, and 83.6% (95% CI: [83.0%, 84.3%]) were linked to care within 90 days. Multiple imputation is recommended for addressing missing linkage data in future analyses when the missing percentage is high. The use of multiple imputation for missing values can result in a better understanding of how programs are performing on key HIV testing and HIV service delivery indicators.

Construction and validation of a Tamil logMAR chart.

PubMed

Varadharajan, Srinivasa; Srinivasan, Krithica; Kumaresan, Brindha

2009-09-01

To design, construct and validate a new Tamil logMAR visual acuity chart based on current recommendations. Ten Tamil letters of equal legibility were identified experimentally and were used in the chart. Two charts, one internally illuminated and one externally illuminated, were constructed for testing at 4 m distance. The repeatability of the two charts was tested. For validation, the two charts were compared with a standard English logMAR chart (ETDRS). When compared to the ETDRS chart, a difference of 0.06 +/- 0.07 and 0.07 +/- 0.07 logMAR was found for the internally and externally illuminated charts respectively. Limits of agreement between the internally illuminated Tamil logMAR chart and ETDRS chart were found to be (-0.08, 0.19), and (-0.07, 0.20) for the externally illuminated chart. The test - retest results showed a difference of 0.02 +/- 0.04 and 0.02 +/- 0.06 logMAR for the internally and externally illuminated charts respectively. Limits of agreement for repeated measurements for the internally illuminated Tamil logMAR chart were found to be (-0.06, 0.10), and (-0.10, 0.14) for the externally illuminated chart. The newly constructed Tamil logMAR charts have good repeatability. The difference in visual acuity scores between the newly constructed Tamil logMAR chart and the standard English logMAR chart was within acceptable limits. This new chart can be used for measuring visual acuity in the literate Tamil population.

A New Method for Incremental Testing of Finite State Machines

NASA Technical Reports Server (NTRS)

Pedrosa, Lehilton Lelis Chaves; Moura, Arnaldo Vieira

2010-01-01

The automatic generation of test cases is an important issue for conformance testing of several critical systems. We present a new method for the derivation of test suites when the specification is modeled as a combined Finite State Machine (FSM). A combined FSM is obtained conjoining previously tested submachines with newly added states. This new concept is used to describe a fault model suitable for incremental testing of new systems, or for retesting modified implementations. For this fault model, only the newly added or modified states need to be tested, thereby considerably reducing the size of the test suites. The new method is a generalization of the well-known W-method and the G-method, but is scalable, and so it can be used to test FSMs with an arbitrarily large number of states.

Advanced solar panel designs

NASA Technical Reports Server (NTRS)

Ralph, E. L.; Linder, E.

1995-01-01

This paper describes solar cell panel designs that utilize new hgih efficiency solar cells along with lightweight rigid panel technology. The resulting designs push the W/kg and W/sq m parameters to new high levels. These new designs are well suited to meet the demand for higher performance small satellites. This paper reports on progress made on two SBIR Phase 1 contracts. One panel design involved the use of large area (5.5 cm x 6.5 cm) GaAs/Ge solar cells of 19% efficiency combined with a lightweight rigid graphite fiber epoxy isogrid substrate configuration. A coupon (38 cm x 38 cm) was fabricated and tested which demonstrated an array specific power level of 60 W/kg with a potential of reaching 80 W/kg. The second panel design involved the use of newly developed high efficiency (22%) dual junction GaInP2/GaAs/Ge solar cells combined with an advanced lightweight rigid substrate using aluminum honeycomb core with high strength graphite fiber mesh facesheets. A coupon (38 cm x 38 cm) was fabricated and tested which demonstrated an array specific power of 105 W/kg and 230 W/sq m. This paper will address the construction details of the panels and an a analysis of the component weights. A strawman array design suitable for a typical small-sat mission is described for each of the two panel design technologies being studied. Benefits in respect to weight reduction, area reduction, and system cost reduction are analyzed and compared to conventional arrays.

Integrating HIV Testing as an Outcome of STD Partner Services for Men Who Have Sex with Men.

PubMed

Katz, David A; Dombrowski, Julia C; Kerani, Roxanne P; Aubin, Mark R; Kern, David A; Heal, David D; Bell, Teal R; Golden, Matthew R

2016-05-01

Men who have sex with men (MSM) with bacterial sexually transmitted diseases (STDs) are at elevated risk for HIV infection, but often do not test for HIV at time of STD diagnosis. We instituted and evaluated a program promoting HIV testing through STD partner services (PS). In May 2012, health departments in Washington State modified STD PS programs with the objective of providing PS to all MSM with early syphilis, gonorrhea, or chlamydial infection and ensuring that those without a prior HIV diagnosis tested for HIV infection. We used chi-square tests and logistic and log-binomial regression to compare the percentage of MSM who received PS, HIV tested, and were newly HIV diagnosed before (January 1, 2010 to April 30, 2012) and during the revised program (May 1, 2012 to August 31, 2014). Among MSM without a prior HIV diagnosis, 2008 (62%) of 3253 preintervention and 3712 (76%) of 4880 during the intervention received PS (p < 0.001). HIV testing among PS recipients increased from 63% to 91% (p < 0.001). PS recipients were more likely to be newly HIV diagnosed than nonrecipients during the preintervention (2.5% vs. 0.93%, p = 0.002) and intervention periods (2.4% vs. 1.4%, p = 0.050). The percentage of MSM with newly diagnosed HIV infection who had a concurrent STD diagnosis increased from 6.6% to 13% statewide (p < 0.0001). Among all MSM with bacterial STDs, 61 (1.9%) preintervention and 104 (2.1%) during the intervention were newly diagnosed with HIV infection (adjusted relative risk = 1.34, p = 0.07). In conclusion, promoting HIV testing through STD PS is feasible and increases HIV testing among MSM. Our findings suggest that integrating HIV testing promotion into STD PS may increase HIV case finding.

Integrating HIV Testing as an Outcome of STD Partner Services for Men Who Have Sex with Men

PubMed Central

Dombrowski, Julia C.; Kerani, Roxanne P.; Aubin, Mark R.; Kern, David A.; Heal, David D.; Bell, Teal R.; Golden, Matthew R.

2016-01-01

Abstract Men who have sex with men (MSM) with bacterial sexually transmitted diseases (STDs) are at elevated risk for HIV infection, but often do not test for HIV at time of STD diagnosis. We instituted and evaluated a program promoting HIV testing through STD partner services (PS). In May 2012, health departments in Washington State modified STD PS programs with the objective of providing PS to all MSM with early syphilis, gonorrhea, or chlamydial infection and ensuring that those without a prior HIV diagnosis tested for HIV infection. We used chi-square tests and logistic and log-binomial regression to compare the percentage of MSM who received PS, HIV tested, and were newly HIV diagnosed before (January 1, 2010 to April 30, 2012) and during the revised program (May 1, 2012 to August 31, 2014). Among MSM without a prior HIV diagnosis, 2008 (62%) of 3253 preintervention and 3712 (76%) of 4880 during the intervention received PS (p < 0.001). HIV testing among PS recipients increased from 63% to 91% (p < 0.001). PS recipients were more likely to be newly HIV diagnosed than nonrecipients during the preintervention (2.5% vs. 0.93%, p = 0.002) and intervention periods (2.4% vs. 1.4%, p = 0.050). The percentage of MSM with newly diagnosed HIV infection who had a concurrent STD diagnosis increased from 6.6% to 13% statewide (p < 0.0001). Among all MSM with bacterial STDs, 61 (1.9%) preintervention and 104 (2.1%) during the intervention were newly diagnosed with HIV infection (adjusted relative risk = 1.34, p = 0.07). In conclusion, promoting HIV testing through STD PS is feasible and increases HIV testing among MSM. Our findings suggest that integrating HIV testing promotion into STD PS may increase HIV case finding. PMID:27158848

Qualified nurses' perceptions of nursing graduates' abilities vary according to specific demographic and clinical characteristics. A descriptive quantitative study.

PubMed

Missen, Karen; McKenna, Lisa; Beauchamp, Alison; Larkins, Jo-Ann

2016-10-01

Evidence from the literature and anecdotally from clinical settings suggests that newly graduated nurses are not fully prepared to be independent practitioners in healthcare settings. The aim of this study was to explore perceptions of qualified nurses in relation to the practice readiness of newly registered nursing graduates and determine whether these views differ according to specific demographic characteristics, clinical settings, and geographical locations. A descriptive quantitative design was used. An online survey tool was used to assess how qualified nurses (n=201) in Victoria, Australia, rated newly graduated nurses' abilities on 51 individual clinical skills/competencies in eight key skill areas. A composite score was calculated for each skill area and a comparative analysis was undertaken on the various cohorts of participants according to their demographic and clinical characteristics using one-way ANOVA and post hoc tests. Newly graduated nurses were found to be lacking competence in two key skill areas and were rated as performing adequately in the remaining six skill areas assessed. Significant differences (p≤0.05) in performance were found according to the age of the nurse, number of years registered, the educational setting in which they undertook their nurse education, their role, and the clinical area in which they worked. There were no significant differences according to whether the nurse worked in the private or public healthcare sector. Few differences were found between nurses working in a metropolitan vs. regional/rural healthcare setting. This is the first study to quantify the scale of this problem. Our findings serve as a reference for both nurse education providers and healthcare settings in better preparing nursing graduates to be competent, safe practitioners in all clinical areas. Copyright © 2016 Elsevier Ltd. All rights reserved.

Research utilisation and critical thinking among newly graduated nurses: predictors for research use. A quantitative cross-sectional study.

PubMed

Wangensteen, Sigrid; Johansson, Inger S; Björkström, Monica E; Nordström, Gun

2011-09-01

The aim was to describe research utilisation among newly graduated nurses and to explore critical thinking dispositions and other individual and contextual factors as possible predictors for research use. Nurses are expected to be research users, and variations in research utilisation are explained by individual and contextual factors. To our knowledge, critical thinking dispositions have not earlier been explored as predictors for research use. A cross-sectional design was chosen. Data collection was carried out from October 2006 to April 2007 using the Research Utilization Questionnaire (RUQ) and the California Critical Thinking Disposition Inventory (CCTDI). The response rate was 33% (n =617). Pearson's chi-square test and regression analyses were used for statistical calculations. The respondents reported a positive attitude towards research, but only 24% (n = 148) were defined as research users. A significantly higher proportion of research users reported high critical thinking scores. Critical thinking explained 20% of the variance in attitude towards research and 11% of the variance in research use. Availability and support to implement research findings was the second strongest predictor for research use. Critical thinking, a significant predictor for attitude towards research and for the use of research, should be recognised and strengthened in nursing education and clinical practice. Contextual factors seem to be important for newly graduated nurses' use of research. Nurse leaders play an important role in nurturing newly graduated nurses' critical thinking and assisting them in transferring their positive attitude towards research into research use. Nurse educators play a significant role in supporting, challenging and supervising nursing students to be critical thinkers and strong believers in research utilisation. © 2011 Blackwell Publishing Ltd.

Screening for tuberculosis among adults newly diagnosed with HIV in sub-Saharan Africa: a cost-effectiveness analysis

PubMed Central

Zwerling, Alice A.; Sahu, Maitreyi; Ngwira, Lucky G.; Khundi, McEwen; Harawa, Tina; Corbett, Elizabeth L.; Chaisson, Richard E.; Dowdy, David W.

2015-01-01

Objective New tools, including light emitting diode (LED) fluorescence microscopy and the molecular assay Xpert MTB/RIF® offer increased sensitivity for TB in persons with HIV but come with higher costs. Using operational data from rural Malawi we explored the potential cost-effectiveness of on-demand screening for TB in low-income countries of sub-Saharan Africa. Design & Methods Costs were empirically collected in four clinics and one hospital using a micro-costing approach, through direct interview and observation from the national TB program perspective. Using decision analysis newly diagnosed persons with HIV were modeled as being screened by one of three strategies: Xpert, LED or standard of care (i.e., at the discretion of the treating physician). Results Cost-effectiveness of TB screening among persons newly diagnosed with HIV was largely determined by two factors: prevalence of active TB among patients newly diagnosed with HIV and volume of testing. In facilities screening at least 50 people with a 6.5% prevalence of TB, or at least 500 people with a 2.5% TB prevalence, screening with Xpert is likely to be cost-effective. At lower prevalence – including that observed in Malawi – LED microscopy may be the preferred strategy, whereas in settings of lower TB prevalence or small numbers of eligible patients, no screening may be reasonable (such that resources can be deployed elsewhere). Conclusions TB screening at the point of HIV diagnosis may be cost-effective in low-income countries of sub-Saharan Africa, but only if a relatively large population with high prevalence of TB can be identified for screening. PMID:26049281

Critical thinking dispositions among newly graduated nurses

PubMed Central

Wangensteen, Sigrid; Johansson, Inger S; Björkström, Monica E; Nordström, Gun

2010-01-01

wangensteen s., johansson i.s., björkström m.e. & nordström g. (2010) Critical thinking dispositions among newly graduated nurses. Journal of Advanced Nursing66(10), 2170–2181. Aim The aim of the study was to describe critical thinking dispositions among newly graduated nurses in Norway, and to study whether background data had any impact on critical thinking dispositions. Background Competence in critical thinking is one of the expectations of nursing education. Critical thinkers are described as well-informed, inquisitive, open-minded and orderly in complex matters. Critical thinking competence has thus been designated as an outcome for judging the quality of nursing education programmes and for the development of clinical judgement. The ability to think critically is also described as reducing the research–practice gap and fostering evidence-based nursing. Methods A cross-sectional descriptive study was performed. The data were collected between October 2006 and April 2007 using the California Critical Thinking Disposition Inventory. The response rate was 33% (n= 618). Pearson’s chi-square tests were used to analyse the data. Results Nearly 80% of the respondents reported a positive disposition towards critical thinking. The highest mean score was on the Inquisitiveness subscale and the lowest on the Truth-seeking subscale. A statistically significant higher proportion of nurses with high critical thinking scores were found among those older than 30 years, those with university education prior to nursing education, and those working in community health care. Conclusion Nurse leaders and nurse teachers should encourage and nurture critical thinking among newly graduated nurses and nursing students. The low Truth-seeking scores found may be a result of traditional teaching strategies in nursing education and might indicate a need for more student-active learning models. PMID:20384637

Buckling Test Results from the 8-Foot-Diameter Orthogrid-Stiffened Cylinder Test Article TA01. [Test Dates: 19-21 November 2008

NASA Technical Reports Server (NTRS)

Hilburger, Mark W.; Waters, W. Allen, Jr.; Haynie, Waddy T.

2015-01-01

Results from the testing of cylinder test article SBKF-P2-CYLTA01 (referred to herein as TA01) are presented. The testing was conducted at the Marshall Space Flight Center (MSFC), November 19?21, 2008, in support of the Shell Buckling Knockdown Factor (SBKF) Project.i The test was used to verify the performance of a newly constructed buckling test facility at MSFC and to verify the test article design and analysis approach used by the SBKF project researchers. TA01 is an 8-foot-diameter (96-inches), 78.0-inch long, aluminum-lithium (Al-Li), orthogrid-stiffened cylindrical shell similar to those used in current state-of-the-art launch vehicle structures and was designed to exhibit global buckling when subjected to compression loads. Five different load sequences were applied to TA01 during testing and included four sub-critical load sequences, i.e., loading conditions that did not cause buckling or material failure, and one final load sequence to buckling and collapse. The sub-critical load sequences consisted of either uniform axial compression loading or combined axial compression and bending and the final load sequence subjected TA01 to uniform axial compression. Traditional displacement transducers and strain gages were used to monitor the test article response at nearly 300 locations and an advanced digital image correlation system was used to obtain low-speed and high-speed full-field displacement measurements of the outer surface of the test article. Overall, the test facility and test article performed as designed. In particular, the test facility successfully applied all desired load combinations to the test article and was able to test safely into the postbuckling range of loading, and the test article failed by global buckling. In addition, the test results correlated well with initial pretest predictions.

75 FR 51876 - Additional Designation of Entities Pursuant to Executive Order 13382

Federal Register 2010, 2011, 2012, 2013, 2014

2010-08-23

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76 FR 40772 - Additional Designation of Entities Pursuant to Executive Order 13382

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-11

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76 FR 12414 - Additional Designation of Entity Pursuant to Executive Order 13382

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-07

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77 FR 35114 - Additional Designation of Entity Pursuant to Executive Order 13382

Federal Register 2010, 2011, 2012, 2013, 2014

2012-06-12

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Biological and Host Range Studies with Bagous affinis, An Indian Weevil that Destroys Hydrilla Tubers. Aquatic Plant Control Research Program.

DTIC Science & Technology

1994-12-01

three times with newly emerged adults and three times with adults at least a month old. Treatments were (a) four hydrilla sprigs, (b) four hydrilla...Methods conducted to determine if feeding on nonhost plants stimulated the develop- ment of flight muscles. Newly emerged females were held in a plastic...Fecundity and adult longevity A fecundity and adult longevity test was conducted with newly emerged adults. Adults were held initially with moist paper

Implementation of Portable Emissions Measurement Systems (PEMS) for the Real-driving Emissions (RDE) Regulation in Europe.

PubMed

Giechaskiel, Barouch; Vlachos, Theodoros; Riccobono, Francesco; Forni, Fausto; Colombo, Rinaldo; Montigny, Francois; Le-Lijour, Philippe; Carriero, Massimo; Bonnel, Pierre; Weiss, Martin

2016-12-04

Vehicles are tested in controlled and relatively narrow laboratory conditions to determine their official emission values and reference fuel consumption. However, on the road, ambient and driving conditions can vary over a wide range, sometimes causing emissions to be higher than those measured in the laboratory. For this reason, the European Commission has developed a complementary Real-Driving Emissions (RDE) test procedure using the Portable Emissions Measurement Systems (PEMS) to verify gaseous pollutant and particle number emissions during a wide range of normal operating conditions on the road. This paper presents the newly-adopted RDE test procedure, differentiating six steps: 1) vehicle selection, 2) vehicle preparation, 3) trip design, 4) trip execution, 5) trip verification, and 6) calculation of emissions. Of these steps, vehicle preparation and trip execution are described in greater detail. Examples of trip verification and the calculations of emissions are given.

Erosive burning research. [for solid-propellant rocket engines

NASA Technical Reports Server (NTRS)

Strand, L.; Yang, L. C.; Nguyen, M. H.; Cohen, N. S.

1986-01-01

A status report is given on the results for the completed tests in a series of motor firings being carried out to measure the effects of the parameters that are considered to most strongly influence the scaling to larger rocket motor sizes of the transition to/or threshold conditions for erosive burning rate augmentation. Propellant burning rates at locations along the axis of the test motors are measured with a newly developed plasma capacitance gauge technique. The measured results are compared with erosive-burning predictions from a supporting ballistics analysis. The completed motor firings have successfully demonstrated response to the designed test variables. The trends with varying propellant burning rate, chamber pressure, and mass flow rate are consistent with existing results, but no pronounced effect of surface roughness has been observed. Rather, the influence of propellant oxidizer particle size on erosive burning is through its effect on the base, no-corssflow burning rate.

Implementation of Portable Emissions Measurement Systems (PEMS) for the Real-driving Emissions (RDE) Regulation in Europe

PubMed Central

Giechaskiel, Barouch; Vlachos, Theodoros; Riccobono, Francesco; Forni, Fausto; Colombo, Rinaldo; Montigny, Francois; Le-Lijour, Philippe; Carriero, Massimo; Bonnel, Pierre; Weiss, Martin

2016-01-01

Vehicles are tested in controlled and relatively narrow laboratory conditions to determine their official emission values and reference fuel consumption. However, on the road, ambient and driving conditions can vary over a wide range, sometimes causing emissions to be higher than those measured in the laboratory. For this reason, the European Commission has developed a complementary Real-Driving Emissions (RDE) test procedure using the Portable Emissions Measurement Systems (PEMS) to verify gaseous pollutant and particle number emissions during a wide range of normal operating conditions on the road. This paper presents the newly-adopted RDE test procedure, differentiating six steps: 1) vehicle selection, 2) vehicle preparation, 3) trip design, 4) trip execution, 5) trip verification, and 6) calculation of emissions. Of these steps, vehicle preparation and trip execution are described in greater detail. Examples of trip verification and the calculations of emissions are given. PMID:28060306

Improved neural network based scene-adaptive nonuniformity correction method for infrared focal plane arrays.

PubMed

Lai, Rui; Yang, Yin-tang; Zhou, Duan; Li, Yue-jin

2008-08-20

An improved scene-adaptive nonuniformity correction (NUC) algorithm for infrared focal plane arrays (IRFPAs) is proposed. This method simultaneously estimates the infrared detectors' parameters and eliminates the nonuniformity causing fixed pattern noise (FPN) by using a neural network (NN) approach. In the learning process of neuron parameter estimation, the traditional LMS algorithm is substituted with the newly presented variable step size (VSS) normalized least-mean square (NLMS) based adaptive filtering algorithm, which yields faster convergence, smaller misadjustment, and lower computational cost. In addition, a new NN structure is designed to estimate the desired target value, which promotes the calibration precision considerably. The proposed NUC method reaches high correction performance, which is validated by the experimental results quantitatively tested with a simulative testing sequence and a real infrared image sequence.

PONDS Watering System for Veggie

NASA Image and Video Library

2018-03-07

Tomato plants are growing under red and blue LED lights in a growth chamber inside a laboratory at the Space Station Processing Facility at NASA’s Kennedy Space Center in Florida. The plant growth is being tested in the Veggie Passive Orbital Nutrient Delivery System (PONDS). Veggie PONDS is a direct follow-on to the Veg-01 and Veg-03 hardware and plant growth validation tests. The primary goal of this newly developed plant growing system, Veggie PONDS, is to demonstrate uniform plant growth. PONDS units have features that are designed to mitigate microgravity effects on water distribution, increase oxygen exchange and provide sufficient room for root zone growth. PONDS is planned for use during Veg-04 and Veg-05 on the International Space Station after the Veggie PONDS Validation flights on SpaceX-14 and OA-9.

Power-gated 32 bit microprocessor with a power controller circuit activated by deep-sleep-mode instruction achieving ultra-low power operation

NASA Astrophysics Data System (ADS)

Koike, Hiroki; Ohsawa, Takashi; Miura, Sadahiko; Honjo, Hiroaki; Ikeda, Shoji; Hanyu, Takahiro; Ohno, Hideo; Endoh, Tetsuo

2015-04-01

A spintronic-based power-gated micro-processing unit (MPU) is proposed. It includes a power control circuit activated by the newly supported power-off instruction for the deep-sleep mode. These means enable the power-off procedure for the MPU to be executed appropriately. A test chip was designed and fabricated using 90 nm CMOS and an additional 100 nm MTJ process; it was successfully operated. The guideline of the energy reduction effects for this MPU was presented, using the estimation based on the measurement results of the test chip. The result shows that a large operation energy reduction of 1/28 can be achieved when the operation duty is 10%, under the condition of a sufficient number of idle clock cycles.

Effectiveness of a newly designed construction uniform for heat strain attenuation in a hot and humid environment.

PubMed

Yi, Wen; Chan, Albert P C; Wong, Francis K W; Wong, Del P

2017-01-01

This study aims to evaluate the effectiveness of a newly designed construction uniform in combating heat stress. Ten male volunteers performed treadmill running in a climatic chamber maintained at 34.5 °C temperature, 75% relative humidity, 0.3 m/s air velocity, and solar radiation of 450 W/m(2) that simulates typical summer working environment of construction sites in Hong Kong. The participants were tested while wearing two kinds of construction uniforms: a commonly worn uniform A, or a newly designed uniform B. It was found during exercise that Tc (38.34 ± 0.14 vs 38.45 ± 0.11 °C, p = 0.03), Tsk (36.01 ± 0.36 vs 36.27 ± 0.34 °C, p = 0.03), HR (162.7 ± 10.1 vs 172.5 ± 9.2 bpm, p < 0.01), PSI (7.0 ± 0.4 vs 7.5 ± 0.5, p = 0.04), thermal sensation (1.7 ± 0.9 vs 2.6 ± 0.7, p = 0.02), and wetness sensation (1.9 ± 0.9 vs 2.6 ± 0.8, p < 0.01) was lower when wearing uniform B than that of uniform A. It was found during recovery that Tc (37.89 ± 0.13 vs 38.06 ± 0.13 °C, p < 0.01), Tsk (35.68 ± 0.37 vs 36.02 ± 0.41 °C, p < 0.01), HR (104.2 ± 10.1 vs 112.6 ± 10.7 bpm, p < 0.01), PSI (3.3 ± 0.7 vs 4.1 ± 1.0, p < 0.01), thermal sensation (0.1 ± 0.9 vs 1.0 ± 0.8, p = 0.02), and wetness sensation (1.1 ± 1.0 vs 2.3 ± 0.8, p = 0.02) was lower when wearing uniform B than that of uniform A. The findings of this study suggested the newly designed construction uniform could reduce thermoregulatory and cardiovascular strain, and improve thermal comfort while exercising in a hot and humid environment. Copyright © 2016 Elsevier Ltd. All rights reserved.

Does Major Illness Cause Financial Catastrophe?

PubMed Central

Cook, Keziah; Dranove, David; Sfekas, Andrew

2010-01-01

Objective We examine the financial impact of major illnesses on the near-elderly and how this impact is affected by health insurance. Data Sources We use RAND Corporation extracts from the Health and Retirement Study from 1992 to 2006.1 Study Design Our dependent variable is the change in household assets, excluding the value of the primary home. We use triple difference median regressions on a sample of newly ill/uninsured near elderly (under age 65) matched to newly ill/insured near elderly. We also include a matched control group of households whose members are not ill. Results Controlling for the effects of insurance status and illness, we find that the median household with a newly ill, uninsured individual suffers a statistically significant decline in household assets of between 30 and 50 percent relative to households with matched insured individuals. Newly ill, insured individuals do not experience a decline in wealth. Conclusions Newly ill/uninsured households appear to be one illness away from financial catastrophe. Newly ill insured households who are matched to uninsured households appear to be protected against financial loss, at least in the near term. PMID:19840132

Evaluation of a new baseplate in reverse total shoulder arthroplasty - comparison of biomechanical testing of stability with roentgenological follow up criteria.

PubMed

Irlenbusch, U; Kohut, G

2015-04-01

To minimize notching problem associated with reversed prostheses, inferior positioning of base plate is recommended. This reduces the risk of notching, but does not eliminate it completely. Both polyethylene/PE-induced osteolysis and implant-to-bone or implant-to-implant contact may still occur, contributing to the risk of screw-breakage and resulting long-term failure. Therefore, the stability and integration of a newly developed base plate without inferior screw and inversion of bearing materials was investigated. Biomechanical assessment of primary stability of the two types of glenoid baseplate (1- and 2-pegged) was carried out according to ASTM F-2028-02 (American Society for Testing and Materials). Patients with a follow-up period of at least 2 years were clinically (n=78) and for most of them radiologically (n=61) examined. The X-rays were evaluated for loosening and scapular notching. The mean values of micromotions after 100,000 cycles showed no relevant differences between the 2-peg and the 1-peg base plates (47 μm for the 2-peg design and 43 μm for the 1-peg design), i.e. both were below the borderline for secure Osseointegration of 150 μm. Radiologically, no signs of loosening or radiolucent lines/RLL were found for both base plates. The mean incidence of inferior scapular notching was 23.6% (42 mm glenoid sphere: 15.8%). Only grade 1 and grade 2 notching was observed. Additionally as result of absence of PE-induced osteolysis shape, size, borderline and location of notching differed from those observed with conventional reverse total shoulder arthroplasty bearing materials. In combination with modified inferior operating technique, the newly designed implant has the potential to reduce the incidence of scapular notching and to avoid both PE-induced osteolysis and metal-screw contact. The new design did not compromise stability of the base plate in any way during the investigation period, as demonstrated both by the data from the biomechanical investigation and also by the radiological follow-up. Level III, case-control study. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

Factors influencing confidential unit exclusions in blood donors.

PubMed

Sümnig, A; Konerding, U; Kohlmann, T; Greinacher, A

2010-04-01

In many countries blood donors can exclude their donated blood from being transfused in a confidential unit exclusion (CUE) process. We aimed to identify characteristics which might influence the decision for CUE. In a 3-step approach we first enrolled 29 German blood donation centers in 2005 and addressed how the clarity of different CUE forms applied in these centers was rated by first time blood donors and also assessed three newly designed CUE forms. Second, we performed a survey on the characteristics of the CUE process including 25 centers. Third, we performed an intervention study, in which the CUE form originally applied in the study centre was compared with a newly developed CUE form in a before-after study design with respect to the corresponding CUE rates. (1) Clarity of the CUE forms varied considerably. (2) The CUE rate was higher (P < 0.05) when nurses rather than a physician were involved in informing the donors and when the CUE form was submitted anonymously instead of being handed to a person. (3) Application of the newly designed CUE form which was rated as being very clear resulted in a 31% decrease in the CUE rate. Design of the CUE form and characteristics of the CUE process may considerably influence the CUE rates.

Fabrication and testing of a newly designed slit system for depth-resolved X-ray diffraction measurements

DOE PAGES

Sinsheimer, John; Bouet, Nathalie; Ghose, Sanjit; ...

2016-10-06

A new system of slits called `spiderweb slits' have been developed for depth-resolved powder or polycrystalline X-ray diffraction measurements. The slits act on diffracted X-rays to select a particular gauge volume of sample, while absorbing diffracted X-rays from outside of this volume. Although the slit geometry is to some extent similar to that of previously developed conical slits or spiral slits, this new design has advantages over the previous ones in use for complex heterogeneous materials and in situ and operando diffraction measurements. For example, the slits can measure a majority of any diffraction cone for any polycrystalline material, overmore » a continuous range of diffraction angles, and work for X-ray energies of tens to hundreds of kiloelectronvolts. In addition, the design is generated and optimized using ray-tracing simulations, and fabricated through laser micromachining. The first prototype was successfully tested at the X17A beamline at the National Synchrotron Light Source, and shows similar performance to simulations, demonstrating gauge volume selection for standard powders, for all diffraction peaks over angles of 2–10°. A similar, but improved, design will be implemented at the X-ray Powder Diffraction beamline at the National Synchrotron Light Source II.« less

Fabrication and testing of a newly designed slit system for depth-resolved X-ray diffraction measurements

DOE Office of Scientific and Technical Information (OSTI.GOV)

Sinsheimer, John; Bouet, Nathalie; Ghose, Sanjit

2016-10-06

A new system of slits called `spiderweb slits' have been developed for depth-resolved powder or polycrystalline X-ray diffraction measurements. The slits act on diffracted X-rays to select a particular gauge volume of sample, while absorbing diffracted X-rays from outside of this volume. Although the slit geometry is to some extent similar to that of previously developed conical slits or spiral slits, this new design has advantages over the previous ones in use for complex heterogeneous materials andin situandoperandodiffraction measurements. For example, the slits can measure a majority of any diffraction cone for any polycrystalline material, over a continuous range ofmore » diffraction angles, and work for X-ray energies of tens to hundreds of kiloelectronvolts. The design is generated and optimized using ray-tracing simulations, and fabricated through laser micromachining. The first prototype was successfully tested at the X17A beamline at the National Synchrotron Light Source, and shows similar performance to simulations, demonstrating gauge volume selection for standard powders, for all diffraction peaks over angles of 2–10°. A similar, but improved, design will be implemented at the X-ray Powder Diffraction beamline at the National Synchrotron Light Source II.« less

Theory-based design and field-testing of an intervention to support women choosing surgery for breast cancer: BresDex.

PubMed

Sivell, Stephanie; Marsh, William; Edwards, Adrian; Manstead, Antony S R; Clements, Alison; Elwyn, Glyn

2012-02-01

Design and undertake usability and field-testing evaluation of a theory-guided decision aid (BresDex) in supporting women choosing surgery for early breast cancer. An extended Theory of Planned Behavior (TPB) and the Common Sense Model of Illness Representations (CSM) guided the design of BresDex. BresDex was evaluated and refined across 3 cycles by interviewing 6 women without personal history of breast cancer, 8 women with personal history of breast cancer who had completed treatment and 11 women newly diagnosed with breast cancer. Participants were interviewed for views on content, presentation (usability) and perceived usefulness towards deciding on treatment (utility). Framework analysis was used, guided by the extended TPB and the CSM. BresDex was positively received in content and presentation (usability). It appeared an effective support to decision-making and useful source for further information, particularly in clarifying attitudes, social norms and perceived behavioral control, and presenting consequences of decisions (utility). This study illustrates the potential benefit of the extended TPB and CSM in designing a decision aid to support women choosing breast cancer surgery. BresDex could provide decision-making support and serve as an additional source of information, to complement the care received from the clinical team. Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

PERLE. Powerful energy recovery linac for experiments. Conceptual design report

NASA Astrophysics Data System (ADS)

Angal-Kalinin, D.; Arduini, G.; Auchmann, B.; Bernauer, J.; Bogacz, A.; Bordry, F.; Bousson, S.; Bracco, C.; Brüning, O.; Calaga, R.; Cassou, K.; Chetvertkova, V.; Cormier, E.; Daly, E.; Douglas, D.; Dupraz, K.; Goddard, B.; Henry, J.; Hutton, A.; Jensen, E.; Kaabi, W.; Klein, M.; Kostka, P.; Lasheras, N.; Levichev, E.; Marhauser, F.; Martens, A.; Milanese, A.; Militsyn, B.; Peinaud, Y.; Pellegrini, D.; Pietralla, N.; Pupkov, Y.; Rimmer, R.; Schirm, K.; Schulte, D.; Smith, S.; Stocchi, A.; Valloni, A.; Welsch, C.; Willering, G.; Wollmann, D.; Zimmermann, F.; Zomer, F.

2018-06-01

A conceptual design is presented of a novel energy-recovering linac (ERL) facility for the development and application of the energy recovery technique to linear electron accelerators in the multi-turn, large current and large energy regime. The main characteristics of the powerful energy recovery linac experiment facility (PERLE) are derived from the design of the Large Hadron electron Collider, an electron beam upgrade under study for the LHC, for which it would be the key demonstrator. PERLE is thus projected as a facility to investigate efficient, high current (HC) (>10 mA) ERL operation with three re-circulation passages through newly designed SCRF cavities, at 801.58 MHz frequency, and following deceleration over another three re-circulations. In its fully equipped configuration, PERLE provides an electron beam of approximately 1 GeV energy. A physics programme possibly associated with PERLE is sketched, consisting of high precision elastic electron–proton scattering experiments, as well as photo-nuclear reactions of unprecedented intensities with up to 30 MeV photon beam energy as may be obtained using Fabry–Perot cavities. The facility has further applications as a general technology test bed that can investigate and validate novel superconducting magnets (beam induced quench tests) and superconducting RF structures (structure tests with HC beams, beam loading and transients). Besides a chapter on operation aspects, the report contains detailed considerations on the choices for the SCRF structure, optics and lattice design, solutions for arc magnets, source and injector and on further essential components. A suitable configuration derived from the here presented design concept may next be moved forward to a technical design and possibly be built by an international collaboration which is being established.

Dispersion of fine phosphor particles by newly developed beads mill

NASA Astrophysics Data System (ADS)

Joni, I. Made; Panatarani, C.; Maulana, Dwindra W.

2016-02-01

Fine phosphor Y2O3:Eu3+ particles has advanced properties compare to conventional particles applied for compact fluorescent lamp (CFL) as three band phosphor. However, suspension of fine particles easily agglomerated during preparation of spray coating of the CFL tube. Therefore, it is introduced newly developed beads mill system to disperse fine phosphor. The beads mill consist of glass beads, dispersing chamber (impellers), separator chamber, slurry pump and motors. The first important performance of beads mill is the performance of the designed on separating the beads with the suspended fine particles. We report the development of beads mill and its separation performance vary in flow rate and separator rotation speeds. The 27 kg of glass beads with 30 µm in size was poured into dispersing chamber and then water was pumped continuously through the slurry pump. The samples for the separation test was obtained every 1 hours vary in rotation speed and slurry flow rate. The results shows that the separation performance was 99.99 % obtained for the rotation speed of >1000 rpm and flow rate of 8 L/minute. The performances of the system was verified by dispersing fine phosphor Y2O3:Eu3+ particles with concentration 1 wt.%. From the observed size distribution of particles after beads mill, it is concluded that the current design of bead mill effectively dispersed fine phosphor Y2O3:Eu3+.

Identifying Needs: a Qualitative Study of women's Experiences Regarding Rapid Genetic Testing for Hereditary Breast and Ovarian Cancer in the DNA BONus Study.

PubMed

Augestad, Mirjam Tonheim; Høberg-Vetti, Hildegunn; Bjorvatn, Cathrine; Sekse, Ragnhild Johanne Tveit

2017-02-01

Genetic testing for hereditary breast and ovarian cancer is increasingly being offered in newly diagnosed breast and ovarian cancer patients. This genetic information may influence treatment decisions. However, there are some concerns that genetic testing offered in an already vulnerable situation might be an extra burden to these women. The aim of this study was to explore the experiences of women who had been offered and accepted genetic testing when newly diagnosed with breast or ovarian cancer. Four semi-structured focus-group interviews were conducted with 17 women recruited from a Norwegian multicenter study. The material was condensed, and conventional qualitative analysis was used to identify patterns in the participants' descriptions. Three core themes were identified: 1) being "beside oneself" 2) altruism and ethical dilemmas 3) the need for support and counselling to assist the decision process. The present study indicates that women who are offered genetic testing when newly diagnosed with breast or ovarian cancer want a consultation with a health professional. Personalized support and counselling might empower women to improve their ability to manage and comprehend this overwhelming situation, and find meaning in this experience.

Development of thermal protection system of the MUSES-C/DASH reentry capsule

NASA Astrophysics Data System (ADS)

Yamada, Tetsuya; Inatani, Yoshifumi; Honda, Masahisa; Hirai, Ken'ich

2002-07-01

In the final phase of the MUSES-C mission, a small capsule with asteroid sample conducts reentry flight directly from the interplanetary transfer orbit at the velocity over 12 km/s. The severe heat flux, the complicated functional requirements, and small weight budget impose several engineering challenges on the designing of the thermal protection system of the capsule. The heat shield is required to function not only as ablator but also as a structural component. The cloth-layered carbon-phenolic ablator, which has higher allowable stress, is developed in newly-devised fabric method for avoiding delamination due to the high aerodynamic heating. The ablation analysis code, which takes into account of the effect of pyrolysis gas on the surface recession rate, has been developed and verified in the arc-heating tests in the facility environment of broad range of enthalpy level. The capsule was designed to be ventilated during the reentry flight up to about atmospheric pressure by the time of parachute deployment by being sealed with porous flow-restrict material. The designing of the thermal protection system, the hardware specifications, and the ground-based test programs of both MUSES-C and DASH capsule are summarized and discussed here in this paper.

People newly in love are more responsive to positive feedback.

PubMed

Brown, Cassandra L; Beninger, Richard J

2012-06-01

Passionate love is associated with increased activity in dopamine-rich regions of the brain. Increased dopamine in these regions is associated with a greater tendency to learn from reward in trial-and-error learning tasks. This study examined the prediction that individuals who were newly in love would be better at responding to reward (positive feedback). In test trials, people who were newly in love selected positive outcomes significantly more often than their single (not in love) counterparts but were no better at the task overall. This suggests that people who are newly in love show a bias toward responding to positive feedback, which may reflect a general bias towards reward-seeking.

Drug resistance in Mexico: results from the National Survey on Drug-Resistant Tuberculosis.

PubMed

Bojorquez-Chapela, I; Bäcker, C E; Orejel, I; López, A; Díaz-Quiñonez, A; Hernández-Serrato, M I; Balandrano, S; Romero, M; Téllez-Rojo Solís, M M; Castellanos, M; Alpuche, C; Hernández-Ávila, M; López-Gatell, H

2013-04-01

To present estimations obtained from a population-level survey conducted in Mexico of prevalence rates of mono-, poly- and multidrug-resistant strains among newly diagnosed cases of pulmonary tuberculosis (TB), as well as the main factors associated with multidrug resistance (combined resistance to isoniazid and rifampicin). Study data came from the National Survey on TB Drug Resistance (ENTB-2008), a nationally representative survey conducted during 2008-2009 in nine states with a stratified cluster sampling design. Samples were obtained for all newly diagnosed cases of pulmonary TB in selected sites. Drug susceptibility testing (DST) was performed for anti-tuberculosis drugs. DST results were obtained for 75% of the cases. Of these, 82.2% (95%CI 79.5-84.7) were susceptible to all drugs. The prevalence of multidrug-resistant TB (MDR-TB) was estimated at 2.8% (95%CI 1.9-4.0). MDR-TB was associated with previous treatment (OR 3.3, 95%CI 1.1-9.4). The prevalence of drug resistance is relatively low in Mexico. ENTB-2008 can be used as a baseline for future follow-up of drug resistance.

Solution of the lossy nonlinear Tricomi equation with application to sonic boom focusing

NASA Astrophysics Data System (ADS)

Salamone, Joseph A., III

Sonic boom focusing theory has been augmented with new terms that account for mean flow effects in the direction of propagation and also for atmospheric absorption/dispersion due to molecular relaxation due to oxygen and nitrogen. The newly derived model equation was numerically implemented using a computer code. The computer code was numerically validated using a spectral solution for nonlinear propagation of a sinusoid through a lossy homogeneous medium. An additional numerical check was performed to verify the linear diffraction component of the code calculations. The computer code was experimentally validated using measured sonic boom focusing data from the NASA sponsored Superboom Caustic and Analysis Measurement Program (SCAMP) flight test. The computer code was in good agreement with both the numerical and experimental validation. The newly developed code was applied to examine the focusing of a NASA low-boom demonstration vehicle concept. The resulting pressure field was calculated for several supersonic climb profiles. The shaping efforts designed into the signatures were still somewhat evident despite the effects of sonic boom focusing.

Evaluation of cyclic flexural fatigue of M-wire nickel-titanium rotary instruments.

PubMed

Al-Hadlaq, Solaiman M S; Aljarbou, Fahad A; AlThumairy, Riyadh I

2010-02-01

This study was conducted to investigate cyclic flexural fatigue resistance of GT series X rotary files made from the newly developed M-wire nickel-titanium alloy compared with GT and Profile nickel-titanium files made from a conventional nickel-titanium alloy. Fifteen files, size 30/0.04, of each type were used to evaluate the cyclic flexural fatigue resistance. A simple device was specifically constructed to measure the time each file type required to fail under cyclic flexural fatigue testing. The results of this experiment indicated that the GT series X files had superior cyclic flexural fatigue resistance than the other 2 file types made from a conventional nickel-titanium alloy (P = .004). On the other hand, the difference between the Profile and the GT files was not statistically significant. The findings of this study suggest that size 30/0.04 nickel-titanium rotary files made from the newly developed M-wire alloy have better cyclic flexural fatigue resistance than files of similar design and size made from the conventional nickel-titanium alloy. Copyright 2010 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.

Development of generalized pressure velocity coupling scheme for the analysis of compressible and incompressible combusting flows

NASA Technical Reports Server (NTRS)

Chen, C. P.; Wu, S. T.

1992-01-01

The objective of this investigation has been to develop an algorithm (or algorithms) for the improvement of the accuracy and efficiency of the computer fluid dynamics (CFD) models to study the fundamental physics of combustion chamber flows, which are necessary ultimately for the design of propulsion systems such as SSME and STME. During this three year study (May 19, 1978 - May 18, 1992), a unique algorithm was developed for all speed flows. This newly developed algorithm basically consists of two pressure-based algorithms (i.e. PISOC and MFICE). This PISOC is a non-iterative scheme and the FICE is an iterative scheme where PISOC has the characteristic advantages on low and high speed flows and the modified FICE has shown its efficiency and accuracy to compute the flows in the transonic region. A new algorithm is born from a combination of these two algorithms. This newly developed algorithm has general application in both time-accurate and steady state flows, and also was tested extensively for various flow conditions, such as turbulent flows, chemically reacting flows, and multiphase flows.

Placement of a Newly Designed Y-Configured Bilateral Self-Expanding Metallic Stent for Hilar Biliary Obstruction: A Pilot Study.

PubMed

Jiao, Dechao; Huang, Kai; Zhu, Ming; Wu, Gang; Ren, Jianzhuang; Wang, Yanli; Han, Xinwei

2017-01-01

Whether unilateral or bilateral drainage should be performed for malignant hilar biliary obstruction remains a matter of debate. Although a Y-stent with a central wide-open mesh facilitates bilateral stent placement, it has its own limitations. This study aims to evaluate the feasibility and efficacy of a newly designed Y-configured bilateral self-expanding metallic stent (SEMS) for the treatment of hilar biliary obstruction. In this retrospective study, 14 consecutive patients with unresectable malignant hilar biliary obstruction (Bismuth type II or higher), who underwent placement of a newly designed Y-configured bilateral SEMS for hilar biliary obstruction from April 2013 to March 2015, were included into this study. Data on technical success, clinical success, stent patency, complications and patient survival were collected. Technical and clinical success was 100 and 92.9 %, respectively. Mean serum bilirubin level was significantly decreased 1 month after stent placement (P < 0.01). Furthermore, two patients (14.3 %) had early complications (one patient had severe hemobilia and one patient had cholangitis), and two patients (14.3 %) had late complications (one patient had cholangitis and one patient had cholecystitis). During the mean follow-up period of 298 days (range 89-465 days), six patients (42.9 %) developed stent occlusion caused by tumor ingrowth or overgrowth (n = 5) and sludge (n = 1). Median stent patency and overall survival times were 281 days (95 % CI 175.9-386.1 days) and 381 days (95 % CI 291.4-470.6 days), respectively. The use of the newly designed Y-configured bilateral SEMS is feasible and effective for hilar biliary obstruction using port docking deployment.

HIV Incidence Estimates Using the Limiting Antigen Avidity EIA Assay at Testing Sites in Kiev City, Ukraine: 2013-2014.

PubMed

Simmons, Ruth; Malyuta, Ruslan; Chentsova, Nelli; Karnets, Iryna; Murphy, Gary; Medoeva, Antonia; Kruglov, Yuri; Yurchenko, Alexander; Copas, Andrew; Porter, Kholoud

2016-01-01

To estimate HIV incidence and highlight the characteristics of persons at greatest risk of HIV in the Ukraine capital, Kiev. Residual samples from newly-diagnosed persons attending the Kiev City AIDS Centre were tested for evidence of recent HIV infection using an avidity assay. Questions on possible risk factors for HIV acquisition and testing history were introduced. All persons (≥16yrs) presenting for an HIV test April'13-March'14 were included. Rates per 100,000 population were calculated using region-specific denominators. During the study period 6370 individuals tested for HIV. Of the 467 individuals newly-diagnosed with HIV, 21 had insufficient samples for LAg testing. Of the remaining 446, 39 (8.7%) were classified as recent with an avidity index <1.5ODn, 10 were reclassified as long-standing as their viral load was <1000 copies/mL, resulting in 29 (6.5%) recent HIV infections. The only independent predictor for a recent infection was probable route of exposure, with MSM more likely to present with a recent infection compared with heterosexual contact [Odds Ratio 8.86; 95%CI 2.65-29.60]. We estimated HIV incidence at 21.5 per 100,000 population, corresponding to 466 new infections. Using population estimates for MSM and PWID, incidence was estimated to be between 2289.6 and 6868.7/100,000 MSM, and 350.4 for PWID. A high proportion of persons newly-infected remain undiagnosed, with MSM disproportionally affected with one in four newly-HIV-diagnosed and one in three recently-HIV-infected. Our findings should be used for targeted public health interventions and health promotion.

HIV Incidence Estimates Using the Limiting Antigen Avidity EIA Assay at Testing Sites in Kiev City, Ukraine: 2013-2014

PubMed Central

Kruglov, Yuri; Yurchenko, Alexander

2016-01-01

Objective To estimate HIV incidence and highlight the characteristics of persons at greatest risk of HIV in the Ukraine capital, Kiev. Method Residual samples from newly-diagnosed persons attending the Kiev City AIDS Centre were tested for evidence of recent HIV infection using an avidity assay. Questions on possible risk factors for HIV acquisition and testing history were introduced. All persons (≥16yrs) presenting for an HIV test April’13–March’14 were included. Rates per 100,000 population were calculated using region-specific denominators. Results During the study period 6370 individuals tested for HIV. Of the 467 individuals newly-diagnosed with HIV, 21 had insufficient samples for LAg testing. Of the remaining 446, 39 (8.7%) were classified as recent with an avidity index <1.5ODn, 10 were reclassified as long-standing as their viral load was <1000 copies/mL, resulting in 29 (6.5%) recent HIV infections. The only independent predictor for a recent infection was probable route of exposure, with MSM more likely to present with a recent infection compared with heterosexual contact [Odds Ratio 8.86; 95%CI 2.65–29.60]. We estimated HIV incidence at 21.5 per 100,000 population, corresponding to 466 new infections. Using population estimates for MSM and PWID, incidence was estimated to be between 2289.6 and 6868.7/100,000 MSM, and 350.4 for PWID. Conclusion A high proportion of persons newly-infected remain undiagnosed, with MSM disproportionally affected with one in four newly-HIV-diagnosed and one in three recently-HIV-infected. Our findings should be used for targeted public health interventions and health promotion. PMID:27276170

Fragmentation Energy-Saving Theory of Full Face Rock Tunnel Boring Machine Disc Cutters

NASA Astrophysics Data System (ADS)

Zhang, Zhao-Huang; Gong, Guo-Fang; Gao, Qing-Feng; Sun, Fei

2017-07-01

Attempts to minimize energy consumption of a tunnel boring machine disc cutter during the process of fragmentation have largely focused on optimizing disc-cutter spacing, as determined by the minimum specific energy required for fragmentation; however, indentation tests showed that rock deforms plastically beneath the cutters. Equations for thrust were developed for both the traditional, popularly employed disc cutter and anew design based on three-dimensional theory. The respective energy consumption for penetration, rolling, and side-slip fragmentations were obtained. A change in disc-cutter fragmentation angles resulted in a change in the nature of the interaction between the cutter and rock, which lowered the specific energy of fragmentation. During actual field excavations to the same penetration length, the combined energy consumption for fragmentation using the newly designed cutters was 15% lower than that when using the traditional design. This paper presents a theory for energy saving in tunnel boring machines. Investigation results showed that the disc cutters designed using this theory were more durable than traditional designs, and effectively lowered the energy consumption.

Clinical characteristics and beta cell function in Chinese patients with newly diagnosed type 2 diabetes mellitus with different levels of serum triglyceride.

PubMed

Zheng, Shuang; Zhou, Huan; Han, Tingting; Li, Yangxue; Zhang, Yao; Liu, Wei; Hu, Yaomin

2015-04-29

To explore clinical characteristics and beta cell function in Chinese patients with newly diagnosed drug naive type 2 diabetes mellitus (T2DM) with different levels of serum triglyceride (TG). Patients with newly diagnosed T2DM (n = 624) were enrolled and divided into different groups according to levels of serum TG. All patients underwent oral glucose tolerance tests and insulin releasing tests. Demographic data, lipid profiles, glucose levels, and insulin profiles were compared between different groups. Basic insulin secretion function index (homeostasis model assessment for beta cell function index, HOMA-β), modified beta cell function index (MBCI), glucose disposition indices (DI), and early insulin secretion function index (insulinogenic index, IGI) were used to evaluate the beta cell function. Patients of newly diagnosed T2DM with hypertriglyceridemia were younger, fatter and had worse lipid profiles, glucose profiles, and high insulin levels than those with normal TG. There is no difference in early phase insulin secretion among groups of newly diagnosed T2DM patients with different TG levels. The basal beta cell function (HOMA-β and MBCI) initially increased along rising TG levels and then decreased as the TG levels rose further. The insulin sensitivity was relatively high in patients with a low level of TG and low with a high level of TG. Hypertriglyceridemia influences clinical characteristics and β cell function of Chinese patients with newly diagnosed T2DM. A better management of dyslipidemia may, to some extent, reduce the effect of lipotoxicity, thereby improving glucose homeostasis in patients with newly diagnosed T2DM.

Age-stratified 5-year risks of cervical precancer among women with enrollment and newly detected HPV infection.

PubMed

Gage, Julia C; Katki, Hormuzd A; Schiffman, Mark; Fetterman, Barbara; Poitras, Nancy E; Lorey, Thomas; Cheung, Li C; Castle, Philip E; Kinney, Walter K

2015-04-01

It is unclear whether a woman's age influences her risk of cervical intraepithelial neoplasia grade 3 or worse (CIN3+) upon detection of HPV. A large change in risk as women age would influence vaccination and screening policies. Among 972,029 women age 30-64 undergoing screening with Pap and HPV testing (Hybrid Capture 2, Qiagen, Germantown, MD) at Kaiser Permanente Northern California (KPNC), we calculated age-specific 5-year CIN3+ risks among women with HPV infections detected at enrollment, and among women with "newly detected" HPV infections at their second screening visit. Women (57,899, 6.0%) had an enrollment HPV infection. Among the women testing HPV negative at enrollment with a second screening visit, 16,724 (3.3%) had a newly detected HPV infection at their second visit. Both enrollment and newly detected HPV rates declined with age (p < 0.001). Women with enrollment versus newly detected HPV infection had higher 5-year CIN3+ risks: 8.5% versus 3.9%, (p < 0.0001). Risks did not increase with age but declined slightly from 30-34 years to 60-64 years: 9.4% versus 7.4% (p = 0.017) for enrollment HPV and 5.1% versus 3.5% (p = 0.014) for newly detected HPV. Among women age 30-64 in an established screening program, women with newly detected HPV infections were at lower risk than women with enrollment infections, suggesting reduced benefit vaccinating women at older ages. Although the rates of HPV infection declined dramatically with age, the subsequent CIN3+ risks associated with HPV infection declined only slightly. The CIN3+ risks among older women are sufficiently elevated to warrant continued screening through age 65. © 2014 UICC.

Age-Stratified 5-Year Risks of Cervical Precancer among Women with Enrollment and Newly Detected HPV Infection

PubMed Central

Gage, Julia C.; Katki, Hormuzd A.; Schiffman, Mark; Fetterman, Barbara; Poitras, Nancy E.; Lorey, Thomas; Cheung, Li C.; Castle, Philip E.; Kinney, Walter K.

2014-01-01

It is unclear whether a woman's age influences her risk of cervical intraepithelial neoplasia grade 3 or worse (CIN3+) upon detection of HPV. A large change in risk as women age would influence vaccination and screening policies. Among 972,029 women age 30-64 undergoing screening with Pap and HPV testing (Hybrid Capture 2, Qiagen, Germantown, MD, USA) at Kaiser Permanente Northern California (KPNC), we calculated age-specific 5-year CIN3+ risks among women with HPV infections detected at enrollment, and among women with “newly detected” HPV infections at their second screening visit. 57,899 women (6.0%) had an enrollment HPV infection. Among the women testing HPV negative at enrollment with a second screening visit, 16,724 (3.3%) had a newly detected HPV infection at their second visit. Both enrollment and newly detected HPV rates declined with age (p<.001). Women with enrollment vs. newly detected HPV infection had higher 5-year CIN3+ risks: 8.5% vs. 3.9%, (p<.0001). Risks did not increase with age but declined slightly from 30-34 years to 60-64 years: 9.4% vs. 7.4% (p=0.017) for enrollment HPV and 5.1% vs. 3.5% (p=0.014) for newly detected HPV. Among women age 30-64 in an established screening program, women with newly detected HPV infections were at lower risk than women with enrollment infections, suggesting reduced benefit vaccinating women at older ages. Although the rates of HPV infection declined dramatically with age, the subsequent CIN3+ risks associated with HPV infection declined only slightly. The CIN3+ risks among older women are sufficiently elevated to warrant continued screening through age 65. PMID:25136967

Depressive symptoms and their impact on health-seeking behaviors in newly-diagnosed HIV-infected patients in Durban, South Africa.

PubMed

Ramirez-Avila, Lynn; Regan, Susan; Giddy, Janet; Chetty, Senica; Ross, Douglas; Katz, Jeffrey N; Freedberg, Kenneth A; Walensky, Rochelle P; Losina, Elena; Bassett, Ingrid V

2012-11-01

We evaluated the prevalence and correlates of depressive symptoms prior to HIV diagnosis and determined the effect of these symptoms on seeking HIV care at an urban and rural clinic in Durban, South Africa. Adults were administered a questionnaire which included the 5-item Mental Health Index (MHI-5) before HIV testing. We determined the depressive symptoms among HIV-infected subjects. Of 1,545 newly-diagnosed HIV-infected subjects, 55% had depressive symptoms by MHI-5 score. Enrolling at the urban clinic and decreasing functional activity score were associated with depressive symptoms. Subjects with depressive symptoms who were referred for HIV testing by a healthcare provider were less likely to obtain a CD4 count than those without depressive symptoms who self-referred for testing. Depressive symptoms were common among newly-diagnosed HIV-infected participants and impacted CD4 uptake. Depression screening at the time of HIV diagnosis is critical for improving linkage to mental health and HIV services in South Africa.

The Effect of Music Therapy Services on Classroom Behaviours of Newly Arrived Refugee Students in Australia--A Pilot Study

ERIC Educational Resources Information Center

Baker, Felicity; Jones, Carolyn

2006-01-01

This pilot study examined the effects of a short-term music therapy program on the classroom behaviours of newly arrived refugee students who were attending an intensive "English as a Second Language" secondary school. A cross-over design with two five-week intervention periods was employed with group music therapy sessions conducted one…

Identifying Potential Biasing Variables in Student Evaluation of Teaching in a Newly Accredited Business Program in the UAE

ERIC Educational Resources Information Center

Badri, Masood A.; Abdulla, Mohamed; Kamali, Mohammed A.; Dodeen, Hamzeh

2006-01-01

Purpose: The purpose of this paper is to investigate the effect of many factors on student evaluation of teaching. Design/methodology/approach: The study analyzed 3,185 student evaluations of faculty from a newly accredited business program at the United Arab Emirates University using univariate and multi-analysis of variance (ANOVA and MANOVA).…

Surveillance of recent HIV infections among newly diagnosed HIV cases in Germany between 2008 and 2014.

PubMed

Hofmann, Alexandra; Hauser, Andrea; Zimmermann, Ruth; Santos-Hövener, Claudia; Bätzing-Feigenbaum, Jörg; Wildner, Stephan; Kücherer, Claudia; Bannert, Norbert; Hamouda, Osamah; Bremer, Viviane; Bartmeyer, Barbara

2017-07-11

The HIV surveillance system in Germany is based on mandatory, anonymous notification of newly diagnosed HIV cases by laboratories. Because the time between HIV infection and the diagnosis of HIV varies widely between persons, it is difficult to determine the number of cases of recent HIV infection among newly diagnosed cases of HIV. In Germany, the BED-capture-enzyme immunoassay (BED-CEIA) has been used to distinguish between recent and long-standing HIV infection. The aim of this analysis is to report the proportion of cases of recent HIV infection among newly diagnosed cases in Germany between 2008 and 2014 and to identify factors associated with recent infections. A sample of voluntary laboratories among all HIV diagnostic laboratories was recruited. Residual blood from HIV diagnostic tests was spotted on filter paper as dried serum or dried plasma spots and was sent along with the notification form of the HIV cases. The BED-CEIA test was performed. A case was defined as recent HIV infection with a BED-CEIA test result of less than 0.8 normalized optical density, with the exclusion of CDC stage C. The proportion of recent newly diagnosed HIV infections among different groups (such as transmission groups, gender or age groups) was calculated. We used logistic regression to identify factors associated with recent HIV infection and to identify subpopulations with high proportions of recent HIV infections. Approximately 10,257 newly diagnosed cases were tested for recency using the BED-CEIA. In total, 3084 (30.4%) of those were recently infected with HIV. The highest proportion of recent HIV infections was found among men who had sex with men (MSM) (35%) and persons between 18 and 25 years of age (43.0%). Logistic regression revealed that female German intravenous drug users with a recent HIV infection had a higher chance of being detected than German MSM (OR 2.27). Surveillance of recent HIV infection is a useful additional tool to monitor the HIV epidemic in Germany. We could observe ongoing HIV transmission in Germany in general and in different subgroups, and we could identify factors associated with recent HIV infection in Germany.

Multitarget-directed tricyclic pyridazinones as G protein-coupled receptor ligands and cholinesterase inhibitors.

PubMed

Pau, Amedeo; Catto, Marco; Pinna, Giovanni; Frau, Simona; Murineddu, Gabriele; Asproni, Battistina; Curzu, Maria M; Pisani, Leonardo; Leonetti, Francesco; Loza, Maria Isabel; Brea, José; Pinna, Gérard A; Carotti, Angelo

2015-06-01

By following a multitarget ligand design approach, a library of 47 compounds was prepared, and they were tested as binders of selected G protein-coupled receptors (GPCRs) and inhibitors of acetyl and/or butyryl cholinesterase. The newly designed ligands feature pyridazinone-based tricyclic scaffolds connected through alkyl chains of variable length to proper amine moieties (e.g., substituted piperazines or piperidines) for GPCR and cholinesterase (ChE) molecular recognition. The compounds were tested at three different GPCRs, namely serotoninergic 5-HT1A, adrenergic α1A, and dopaminergic D2 receptors. Our main goal was the discovery of compounds that exhibit, in addition to ChE inhibition, antagonist activity at 5-HT1A because of its involvement in neuronal deficits typical of Alzheimer's and other neurodegenerative diseases. Ligands with nanomolar affinity for the tested GPCRs were discovered, but most of them behaved as dual antagonists of α1A and 5-HT1A receptors. Nevertheless, several compounds displaying this GPCR affinity profile also showed moderate to good inhibition of AChE and BChE, thus deserving further investigations to exploit the therapeutic potential of such unusual biological profiles. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

A Newly Designed Mobile-Based Computerized Cognitive Addiction Therapy App for the Improvement of Cognition Impairments and Risk Decision Making in Methamphetamine Use Disorder: Randomized Controlled Trial.

PubMed

Zhu, Youwei; Jiang, Haifeng; Su, Hang; Zhong, Na; Li, Runji; Li, Xiaotong; Chen, Tianzhen; Tan, Haoye; Du, Jiang; Xu, Ding; Yan, Huan; Xu, Dawen; Zhao, Min

2018-06-20

Cognitive rehabilitation therapy has been found to improve cognitive deficits and impulse control problems in methamphetamine use disorder (MUD). However, there is limited research regarding this therapy's feasibility when using mobile-based health technologies in supporting recovery from MUD in China. The main aim of this study was to test whether 4 weeks of a newly designed computerized cognitive addiction therapy (CCAT) app can improve cognitive impairments, eliminate drug-related attention bias, and attenuate risk decision-making behaviors in participants with MUD. Forty MUD participants were assigned randomly to either the CCAT group (n=20), who received 4 weeks of CCAT plus regular detoxification treatment as usual, or the control group (n=20), who only received the regular detoxification treatment as usual, in drug rehabilitation centers in Shanghai. The CCAT was designed by combine methamphetamine use-related picture stimuli with cognitive training with the aim of improving cognitive function and eliminating drug-related attention bias. The CogState Battery, Delay Discounting Task (DDT), Iowa Gambling Task (IGT), and Balloon Analog Risk Task (BART) were administered face-to-face to all participants before and after CCAT interventions. Forty male patients were recruited. The mean age was 32.70 (SD 5.27) years in the CCAT group and mean 35.05 (SD 8.02) years in the control group. Compared to the control group, CCAT improved working memory in the CCAT group (P=.01). Group×time interactions were observed among DDT, IGT, and BART tasks, with rates of discounting delayed rewards, IGT, and BART scores (P<.001) being reduced among those who received CCAT, whereas no changes were found in the control group. The newly designed CCAT can help to improve cognitive impairment and impulsive control in MUD. Further study is needed to understand the underlying brain mechanisms of the cognitive therapy. ClinicalTrials.gov NCT03318081; https://clinicaltrials.gov/ct2/show/NCT03318081 (Archived by WebCite at https://clinicaltrials.gov/ct2/show/NCT03318081). ©Youwei Zhu, Haifeng Jiang, Hang Su, Na Zhong, Runji Li, Xiaotong Li, Tianzhen Chen, Haoye Tan, Jiang Du, Ding Xu, Huan Yan, Dawen Xu, Min Zhao. Originally published in JMIR Mhealth and Uhealth (http://mhealth.jmir.org), 20.06.2018.

KENNEDY SPACE CENTER, FLA. - On a tour of the KSC Beach Corrosion Test Site, Testbed Manager Louis MacDowell (right) explains to Center Director Jim Kennedy about the test blocks being used to test a newly developed coating to protect steel inside concrete. Between MacDowell and Kennedy are Dr. Paul Hintze and Lead Scientist Dr. Luz Marina Calle. The KSC Beach Corrosion Test Site was established in the 1960s and has provided more than 30 years of historical information on the long-term performance of many materials in use at KSC and other locations around the world. Located 100 feet from the Atlantic Ocean approximately 1 mile south of the Space Shuttle launch sites, the test facility includes an atmospheric exposure site, a flowing seawater exposure site, and an on-site electrochemistry laboratory and monitoring station. The beach laboratory is used to conduct real-time corrosion experiments and provides for the remote monitoring of surrounding weather conditions. The newly added flowing seawater immersion facility provides for the immersion testing of materials and devices under controlled conditions.

NASA Image and Video Library

2003-08-21

KENNEDY SPACE CENTER, FLA. - On a tour of the KSC Beach Corrosion Test Site, Testbed Manager Louis MacDowell (right) explains to Center Director Jim Kennedy about the test blocks being used to test a newly developed coating to protect steel inside concrete. Between MacDowell and Kennedy are Dr. Paul Hintze and Lead Scientist Dr. Luz Marina Calle. The KSC Beach Corrosion Test Site was established in the 1960s and has provided more than 30 years of historical information on the long-term performance of many materials in use at KSC and other locations around the world. Located 100 feet from the Atlantic Ocean approximately 1 mile south of the Space Shuttle launch sites, the test facility includes an atmospheric exposure site, a flowing seawater exposure site, and an on-site electrochemistry laboratory and monitoring station. The beach laboratory is used to conduct real-time corrosion experiments and provides for the remote monitoring of surrounding weather conditions. The newly added flowing seawater immersion facility provides for the immersion testing of materials and devices under controlled conditions.

Failure Study of Composite Materials by the Yeh-Stratton Criterion

NASA Technical Reports Server (NTRS)

Yeh, Hsien-Yang; Richards, W. Lance

1997-01-01

The newly developed Yeh-Stratton (Y-S) Strength Criterion was used to study the failure of composite materials with central holes and normal cracks. To evaluate the interaction parameters for the Y-S failure theory, it is necessary to perform several biaxial loading tests. However, it is indisputable that the inhomogeneous and anisotropic nature of composite materials have made their own contribution to the complication of the biaxial testing problem. To avoid the difficulties of performing many biaxial tests and still consider the effects of the interaction term in the Y-S Criterion, a simple modification of the Y-S Criterion was developed. The preliminary predictions by the modified Y-S Criterion were relatively conservative compared to the testing data. Thus, the modified Y-S Criterion could be used as a design tool. To further understand the composite failure problem, an investigation of the damage zone in front of the crack tip coupled with the Y-S Criterion is imperative.

DEVELOPMENT OF AG-1 SECTION FI ON METAL MEDIA FILTERS - 9061

DOE Office of Scientific and Technical Information (OSTI.GOV)

Adamson, D; Charles A. Waggoner, C

Development of a metal media standard (FI) for ASME AG-1 (Code on Nuclear Air and Gas Treatment) has been under way for almost ten years. This paper will provide a brief history of the development process of this section and a detailed overview of its current content/status. There have been at least two points when dramatic changes have been made in the scope of the document due to feedback from the full Committee on Nuclear Air and Gas Treatment (CONAGT). Development of the proposed section has required resolving several difficult issues associated with scope; namely, filtering efficiency, operating conditions (mediamore » velocity, pressure drop, etc.), qualification testing, and quality control/acceptance testing. A proposed version of Section FI is currently undergoing final revisions prior to being submitted for balloting. The section covers metal media filters of filtering efficiencies ranging from medium (less than 99.97%) to high (99.97% and greater). Two different types of high efficiency filters are addressed; those units intended to be a direct replacement of Section FC fibrous glass HEPA filters and those that will be placed into newly designed systems capable of supporting greater static pressures and differential pressures across the filter elements. Direct replacements of FC HEPA filters in existing systems will be required to meet equivalent qualification and testing requirements to those contained in Section FC. A series of qualification and quality assurance test methods have been identified for the range of filtering efficiencies covered by this proposed standard. Performance characteristics of sintered metal powder vs. sintered metal fiber media are dramatically different with respect to parameters like differential pressures and rigidity of the media. Wide latitude will be allowed for owner specification of performance criteria for filtration units that will be placed into newly designed systems. Such allowances will permit use of the most appropriate metal media for a system as specified by the owner with respect to material of manufacture, media velocity, system maximum static pressure, maximum differential pressure across the filter, and similar parameters.« less

76 FR 50813 - Designation of Two Entities Pursuant to Executive Order 13382

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-16

... DEPARTMENT OF THE TREASURY Office of Foreign Assets Control Designation of Two Entities Pursuant... newly designated entities whose property and interests in property are blocked pursuant to Executive... entities identified in this notice is effective on August 10, 2011. FOR FURTHER INFORMATION CONTACT...

Revitalising Assessment Design: What Is Holding New Lecturers Back?

ERIC Educational Resources Information Center

Norton, Lin; Norton, Bill; Shannon, Lee

2013-01-01

This paper reports on a survey study exploring new lecturers' views on assessment design (using a questionnaire called the Assessment Design Inventory) with 586 newly qualified or still qualifying lecturers from UK universities. A factor analysis established two factors labelled "desirable practice" and "constraints".…

Shoulder joint abduction motion test bench: a new shoulder test bench for in vitro experiments with active muscle force simulation.

PubMed

Onder, Ursula; Blauth, Michael; Kralinger, Franz; Schmoelz, Werner

2012-05-30

In our society the average age is increasing, as are the number of proximal humeral head fractures. For fixation of these fractures, an increasing number of implants are available. New fixation devices should be compared biomechanically with established methods in a standardized fashion. The test bench that was designed was intended to simulate abduction motion of the humerus actively induced by muscle forces. We used three pneumatic muscles to apply forces to the tendons of the musculus supraspinatus and the bifid musculus deltoideus. Thus, it was possible to create an active abduction in the scapular plane. Two different fracture models (with and without medial support) were stabilised with an angular stable plate in sawbone models to reproduce a known clinical outcome with the newly designed test setup. The resultant force acting on the proximal humerus reached approximately 47% BW (per cent body weight), which amounted to 329.0 N (SD: 21.76). The supraspinatus reached maximum forces of 254.7 N (SD: 20.1) and the deltoid muscle 258.9 N (SD: 16.5). Fracture gap instrumentation with medial support resulted in a significantly reduced per-cycle fracture gap motion. The performance evaluation showed that the simulator produced predicable, reproducible movements with physiological muscle force magnitudes.

Scaffold-hopping from xanthines to tricyclic guanines: A case study of dipeptidyl peptidase 4 (DPP4) inhibitors

DOE Office of Scientific and Technical Information (OSTI.GOV)

Pissarnitski, Dmitri A.; Zhao, Zhiqiang; Cole, David

2016-11-01

Molecular modeling of unbound tricyclic guanine scaffolds indicated that they can serve as effective bioisosteric replacements of xanthines. This notion was further confirmed by a combination of X-ray crystallography and SAR studies, indicating that tricyclic guanine DPP4 inhibitors mimic the binding mode of xanthine inhibitors, exemplified by linagliptin. Realization of the bioisosteric relationship between these scaffolds potentially will lead to a wider application of cyclic guanines as xanthine replacements in drug discovery programs for a variety of biological targets. Newly designed DPP4 inhibitors achieved sub-nanomolar potency range and demonstrated oral activity in vivo in mouse glucose tolerance test.

KSC-2009-6464

NASA Image and Video Library

2009-11-19

CAPE CANAVERAL, Fla. – This newly designed glove is one of the entries in the 2009 Astronaut Glove Challenge, part of NASA’s Centennial Challenges Program, at the Astronaut Hall of Fame near NASA’s Kennedy Space Center in Florida. The nationwide competition focused on developing improved pressure suit gloves for astronauts to use while working in space. During the challenge, inventors tested the gloves to measure dexterity and strength during operation in a glove box which simulates the vacuum of space. Centennial Challenges is NASA’s program of technology prizes for the citizen-inventor. The winning prize for the Glove Challenge is $250,000 provided by the Centennial Challenges Program. Photo credit: NASA/Kim Shiflett

Rapid detection of Lactobacillus kefiranofaciens in kefir grain and kefir milk using newly developed real-time PCR.

PubMed

Kim, Dong-Hyeon; Chon, Jung-Whan; Kim, Hong-Seok; Yim, Jin-Hyeok; Kim, Hyunsook; Seo, Kun-Ho

2015-04-01

Lactobacillus kefiranofaciens is an indicator microorganism for kefir and a key factor in kefir grain formation and kefiran production. We designed a novel real-time PCR primer and probe set, LKF_KU504, for the rapid detection of L. kefiranofaciens. In inclusivity and exclusivity tests, only 14 L. kefiranofaciens strains were positive among 61 microorganisms, indicating 100 % sensitivity and specificity. The LKF_KU504 set also differentiated kefir milk from 30 commercial nonkefir yogurts. The levels of L. kefiranofaciens in kefir grain and kefir milk were significantly different, indicating L. kefiranofaciens was more concentrated in kefir grain than in kefir milk.

Development of an adsorption compressor for use in cryogenic refrigeration

NASA Technical Reports Server (NTRS)

Schember, Helen R.

1989-01-01

A new compressor with no moving parts has been developed which is able to supply a source of high-pressure gas to a Joule-Thompson based cryogenic refrigerator. The compressor relies on a newly implemented combination of high-surface-area Saran carbon (sorbent) and krypton gas (working fluid). In addition, an integral gas-gap heat switch is used to provide improved overall efficiency. A prototype compressor has been designed, built, and tested as a part of the Jet Propulsion Laboratory effort in sorption refrigeration. Performance data from the prototype unit described here demonstrate successful compressor performance and good agreement with theoretical predictions.

Research on Modularized Design and Allocation of Infectious Disease Prevention and Control Equipment in China.

PubMed

Zhao, Xin; Wang, Yun-Dou; Zhang, Xiao-Feng; Gao, Shu-Tian; Guo, Li-Jun; Sun, Li-Na

2017-06-01

For the prevention and control of newly emergent or sudden infectious diseases, we built an on-site, modularized prevention and control system and tested the equipment by using the clustering analysis method. On the basis of this system, we propose a modular equipment allocation method and 4 applications of this method for different types of infectious disease prevention and control. This will help to improve the efficiency and productivity of anti-epidemic emergency forces and will provide strong technical support for implementing more universal and serialized equipment in China. (Disaster Med Public Health Preparedness. 2017;11:375-382).

[Combined behavioural and neuroscientific insights can improve anti-tobacco strategies].

PubMed

Soriano, Alice; Rieu, Dorothée; Oullier, Olivier

2013-11-01

In France, cognitive science (e.g., eye-tracking) and neuroscience (e.g., functional neuroimaging) are not used to develop and test anti-tobacco strategies. The newly found knowledge in behavioral and brain sciences could provide valuable insights in the understanding of attentional, emotional, memorization and decision-making processes at play when tobacco addicts are exposed to prevention messages. We argue that neuroscientific methods should be used in the fight against tobacco to better design and evaluate the impact of measures such as combined text and graphic (shock) warnings, neutral packets and support to people who want to stop smoking. © 2013 médecine/sciences – Inserm.

Influence of hip joint simulator design and mechanics on the wear and creep of metal-on-polyethylene bearings

PubMed Central

Ali, Murat; Al-Hajjar, Mazen; Partridge, Susan; Williams, Sophie; Fisher, John; Jennings, Louise M

2016-01-01

Hip joint simulators are used extensively for preclinical testing of hip replacements. The variation in simulator design and test conditions used worldwide can affect the tribological performance of polyethylene. The aim of this study was to assess the effects of simulator mechanics and design on the wear and creep of ultra-high-molecular-weight polyethylene. In the first part of this study, an electromechanical simulator and pneumatic simulator were used to compare the wear and creep of metal-on-polyethylene components under the same standard gait conditions. In the second part of the study, the same electromechanical hip joint simulator was used to investigate the influence of kinematics on wear. Higher wear rates and penetration depths were observed from the electromechanical simulator compared with the pneumatic simulator. When adduction/abduction was introduced to the gait cycle, there was no significant difference in wear with that obtained under the gait cycle condition without adduction/abduction. This study confirmed the influence of hip simulator design and loading conditions on the wear of polyethylene, and therefore direct comparisons of absolute wear rates between different hip joint simulators should be avoided. This study also confirmed that the resulting wear path was the governing factor in obtaining clinically relevant wear rates, and this can be achieved with either two axes or three axes of rotations. However, three axes of rotation (with the inclusion of adduction/abduction) more closely replicate clinical conditions and should therefore be the design approach for newly developed hip joint simulators used for preclinical testing. PMID:27160559

Influence of hip joint simulator design and mechanics on the wear and creep of metal-on-polyethylene bearings.

PubMed

Ali, Murat; Al-Hajjar, Mazen; Partridge, Susan; Williams, Sophie; Fisher, John; Jennings, Louise M

2016-05-01

Hip joint simulators are used extensively for preclinical testing of hip replacements. The variation in simulator design and test conditions used worldwide can affect the tribological performance of polyethylene. The aim of this study was to assess the effects of simulator mechanics and design on the wear and creep of ultra-high-molecular-weight polyethylene. In the first part of this study, an electromechanical simulator and pneumatic simulator were used to compare the wear and creep of metal-on-polyethylene components under the same standard gait conditions. In the second part of the study, the same electromechanical hip joint simulator was used to investigate the influence of kinematics on wear. Higher wear rates and penetration depths were observed from the electromechanical simulator compared with the pneumatic simulator. When adduction/abduction was introduced to the gait cycle, there was no significant difference in wear with that obtained under the gait cycle condition without adduction/abduction. This study confirmed the influence of hip simulator design and loading conditions on the wear of polyethylene, and therefore direct comparisons of absolute wear rates between different hip joint simulators should be avoided. This study also confirmed that the resulting wear path was the governing factor in obtaining clinically relevant wear rates, and this can be achieved with either two axes or three axes of rotations. However, three axes of rotation (with the inclusion of adduction/abduction) more closely replicate clinical conditions and should therefore be the design approach for newly developed hip joint simulators used for preclinical testing. © IMechE 2016.

Three-dimensional finite element analysis of a newly designed onplant miniplate anchorage system.

PubMed

Liu, Lin; Qu, Yin-Ying; Jiang, Li-Jun; Zhou, Qian; Tang, Tian-Qi

2016-06-01

The purpose of this research was to evaluate the structural stress and deformation of a newly designed onplant miniplate anchorage system compared to a standard anchorage system. A bone block integrated with a novel miniplate and fixation screw system was simulated in a three-dimensional model and subjected to force at different directions. The stress distribution and deformation of the miniplate system and cortical bone were evaluated using the three-dimensional finite element method. The results showed that the stress on the plate system and bone was linearly proportional to the force magnitude and was higher when the force was in a vertical direction (Y-axis). Stress and deformation values of the two screws (screw 1 and 2) were asymmetric when the force was added along Y-axis and was greater in screw 1. The highest deformation value of the screws was 7.5148 μm, much smaller than the limit value. The load was decreased for each single miniscrew, and the ability of the new anchorage system to bear the load was also enhanced to some degree. It was suggested that the newly designed onplant miniplate anchorage system is effective, easily implanted and minimally invasive.

Methodologies for Verification and Validation of Space Launch System (SLS) Structural Dynamic Models

NASA Technical Reports Server (NTRS)

Coppolino, Robert N.

2018-01-01

Responses to challenges associated with verification and validation (V&V) of Space Launch System (SLS) structural dynamics models are presented in this paper. Four methodologies addressing specific requirements for V&V are discussed. (1) Residual Mode Augmentation (RMA), which has gained acceptance by various principals in the NASA community, defines efficient and accurate FEM modal sensitivity models that are useful in test-analysis correlation and reconciliation and parametric uncertainty studies. (2) Modified Guyan Reduction (MGR) and Harmonic Reduction (HR, introduced in 1976), developed to remedy difficulties encountered with the widely used Classical Guyan Reduction (CGR) method, are presented. MGR and HR are particularly relevant for estimation of "body dominant" target modes of shell-type SLS assemblies that have numerous "body", "breathing" and local component constituents. Realities associated with configuration features and "imperfections" cause "body" and "breathing" mode characteristics to mix resulting in a lack of clarity in the understanding and correlation of FEM- and test-derived modal data. (3) Mode Consolidation (MC) is a newly introduced procedure designed to effectively "de-feature" FEM and experimental modes of detailed structural shell assemblies for unambiguous estimation of "body" dominant target modes. Finally, (4) Experimental Mode Verification (EMV) is a procedure that addresses ambiguities associated with experimental modal analysis of complex structural systems. Specifically, EMV directly separates well-defined modal data from spurious and poorly excited modal data employing newly introduced graphical and coherence metrics.

Microvessel Density Evaluation of the Effect of Enamel Matrix Derivative on Soft Tissue After Implant Placement: A Preliminary Study.

PubMed

Guimarães, George Furtado; de Araújo, Vera Cavalcanti; Nery, James Carlos; Peruzzo, Daiane Cristina; Soares, Andresa Borges

2015-01-01

Enamel matrix derivative (EMD) is commonly used in periodontal therapy and has been used successfully for periodontal regeneration. In addition, this material has a possible angiogenic effect that has been associated with enhanced wound healing. The aim of this study was to evaluate the effect of EMD on microvessel density (angiogenesis) on the soft tissues surrounding newly placed implants after 14 days. Five patients were selected, each requiring at least one implant on each side of the maxilla, in a split-mouth experimental design. The implants were placed in a two-stage procedure. Each side was then randomized as test or control. On the test side, 0.1 mL of EMD was topically applied to the soft tissues surrounding the implants, while the control side did not receive any treatment. Second-stage surgery was performed after 14 days. A 6-mm punch biopsy was performed for each implant, with the samples subsequently prepared for histology and immunohistochemistry. Quantitative vascularization analysis was performed, which involved counting three areas or "hotspots" containing vessels strongly positive for CD34 and CD105, a pan-endothelial and new vessel marker, respectively. There was no significant difference between test and control groups when evaluating the formation of new blood vessels. The total number of blood vessels, however, was significantly higher in the group treated with EMD (test group). Within the limits of the present study, it can be concluded that topical application of EMD on the soft tissues surrounding newly placed implants resulted in an increased number of blood vessels at 14 days, suggesting that EMD may play a beneficial role in this aspect of wound healing.

Connective tissue graft as a biological barrier for guided tissue regeneration in intrabony defects: a histological study in dogs.

PubMed

Ribeiro, Fernando Salimon; Pontes, Ana Emília Farias; Zuza, Elizangela Partata; da Silva, Vanessa Camila; Lia, Raphael Carlos Comelli; Marcantonio Junior, Elcio

2015-06-01

The use of the autogenous periosteal graft as biological barrier has been proposed for periodontal regeneration. The aim of this study was to evaluate the histometric findings of the subepithelial connective tissue graft as barrier in intrabony defects compared to a bioabsorbable membrane. Three-walled intrabony defects were created surgically in the mesial aspect of the right and left maxillary canines in five healthy mongrel dogs. The defects were chronified, and two types of barriers were randomly carried out for guided tissue regeneration in a split-mouth design: the test group with a subepithelial connective tissue graft and the control group with a bioabsorbable membrane. The specimens were processed for histometric analyses of the epithelium (E), connective tissue (CT), newly formed cementum (NC), new bone (NB), and total newly formed tissues (NFT). The test side showed smaller mean of NC (3.6 ± 1.2), NB (2.1 ± 0.7), and NFT (7.7 ± 0.8) than the control group (NC 7.3 ± 0.5; NB 5.3 ± 1.3; NFT 10.1 ± 2.2; P < 0.05). No statistically significant differences were verified for E (test 3.1 ± 2.0; control 2.8 ± 2.1; P > 0.05) and CT (test 2.5 ± 1.1; control 2.0 ± 0.5; P > 0.05) between groups. The bioabsorbable membrane was more effective in maintaining the space for periodontal regeneration than periosteal connective graft when used as barrier. The bioabsorbable membrane showed more favorable regenerative results in intrabony defects in dogs than the subepithelial connective tissue graft as biological barrier.

Costs of voluntary rapid HIV testing and counseling in jails in 4 states--advancing HIV Prevention Demonstration Project, 2003-2006.

PubMed

Shrestha, Ram K; Sansom, Stephanie L; Richardson-Moore, April; French, P Tyler; Scalco, Beth; Lalota, Marlene; Llanas, Michelle; Stodola, James; Macgowan, Robin; Margolis, Andrew

2009-02-01

To assess the costs of rapid human immunodeficiency virus (HIV) testing and counseling to identify new diagnoses of HIV infection among jail inmates. We obtained program costs and testing outcomes from rapid HIV testing and counseling services provided in jails from March 1, 2004, through February 28, 2005, in Florida, Louisiana, New York, and Wisconsin. We obtained annual program delivery costs-fixed and variable costs-from each project area. We estimated the average cost of providing counseling and testing to HIV-negative and HIV-infected inmates and estimated the cost per newly diagnosed HIV infection. In the 4 project areas, 17,433 inmates (range, 2185-6463) were tested: HIV infection was diagnosed for 152 inmates (range, 4-81). The average cost of testing ranged from $29.46 to $44.98 for an HIV-negative inmate and from $71.37 to $137.72 for an HIV-infected inmate. The average cost per newly diagnosed HIV infection ranged from $2,451 to $25,288. Variable costs were 61% to 86% of total costs. The cost of identifying jail inmates with newly diagnosed HIV infection by using rapid HIV testing varied according to the prevalence of undiagnosed HIV infection among inmates tested in project areas. Variations in the cost of testing HIV-negative and HIV-infected inmates were because of the differences in wages, travel to the jails, and the amount of time spent on counseling and testing. Program managers can use these data to gauge the cost of initiating counseling and testing programs in jails or to streamline current programs.

75 FR 10345 - Designation of Entities and Individual Pursuant to Executive Order 13382

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-05

... DEPARTMENT OF THE TREASURY Office of Foreign Assets Control Designation of Entities and Individual... four newly-designated entities and one individual whose property and interests in property are blocked... Order 13382, of the entities and individual identified in this notice is effective on February 10, 2010...

76 FR 52384 - Designation of Additional Entities Pursuant to Executive Order 13405

Federal Register 2010, 2011, 2012, 2013, 2014

2011-08-22

... DEPARTMENT OF THE TREASURY Office of Foreign Assets Control Designation of Additional Entities... Assets Control (``OFAC'') is publishing the names of four newly-designated entities whose property and... the Director of OFAC of the four entities identified in this notice, pursuant to Executive [[Page...

Stripping potential of bituminous concrete.

DOT National Transportation Integrated Search

1978-01-01

Laboratory data were gathered with a newly developed stripping test in anticipation that the test would be adopted for use by the Department. In addition to providing experience in the performance of the test and interpretation of test results, the i...

Air cleaning performance of a new environmentally controlled primary crusher operator booth

PubMed Central

Organiscak, J.A.; Cecala, A.B.; Zimmer, J.A.; Holen, B.; Baregi, J.R.

2016-01-01

The National Institute for Occupational Safety and Health (NIOSH) cooperated with 3M Company in the design and testing of a new environmentally controlled primary crusher operator booth at the company’s Wausau granite quarry near Wausau, WI. This quarry had an older crusher booth without a central heating, ventilation and air conditioning (HVAC) system, and without an air filtration and pressurization system. A new replacement operator booth was designed and installed by 3M based on design considerations from past NIOSH research on enclosed cab filtration systems. NIOSH conducted pre-testing of the old booth and post-testing of the new booth to assess the new filtration and pressurization system’s effectiveness in controlling airborne dusts and particulates. The booth’s dust and particulate control effectiveness is described by its protection factor, expressed as a ratio of the outside to inside concentrations measured during testing. Results indicate that the old booth provided negligible airborne respirable dust protection and low particulate protection from the outside environment. The newly installed booth provided average respirable dust protection factors from 2 to 25 over five shifts of dust sampling with occasional worker ingress and egress from the booth, allowing some unfiltered contaminants to enter the enclosure. Shorter-term particle count testing outside and inside the booth under near-steady-state conditions, with no workers entering or exiting the booth, resulted in protection factors from 35 to 127 on 0.3- to 1.0-μm respirable size particulates under various HVAC airflow operating conditions. PMID:26937052

Design and implementation of smart sensor nodes for wireless disaster monitoring systems

NASA Astrophysics Data System (ADS)

Chen, Yih-Fan; Wu, Wen-Jong; Chen, Chun-Kuang; Wen, Chih-Min; Jin, Ming-Hui; Gau, Chung-Yun; Chang, Chih-Chie; Lee, Chih-Kung

2004-07-01

A newly developed smart sensor node that can monitor the safety of temporary structures such as scaffolds at construction sites is detailed in this paper. The design methodology and its trade-offs, as well as its influence on the optimization of sensor networks, is examined. The potential impact on civil engineering construction sites, environmental and natural disaster pre-warning issues, etc., all of which are foundations of smart sensor nodes and corresponding smart sensor networks, is also presented. To minimize the power requirements in order to achieve a true wireless system both in terms of signal and power, a sensor node was designed by adopting an 8051-based micro-controller, an ISM band RF transceiver, and an auto-balanced strain gage signal conditioner. With the built-in RF transceiver, all measurement data can be transmitted to a local control center for data integrity, security, central monitoring, and full-scale analysis. As a battery is the only well-established power source and there is a strong desire to eliminate the need to install bulky power lines, this system designed includes a battery-powered core with optimal power efficiency. To further extend the service life of the built-in power source, a power control algorithm has been embedded in the microcontroller of each sensor node. The entire system has been verified by experimental tests on full-scale scaffold monitoring. The results show that this system provides a practical method to monitor the structure safety in real time and possesses the potential of reducing maintenance costs significantly. The design of the sensor node, central control station, and the integration of several kinds of wireless communication protocol, all of which are successfully integrated to demonstrate the capabilities of this newly developed system, are detailed. Potential impact to the network topology is briefly examined as well.

The effect of preceptor role effectiveness on newly licensed registered nurses' perceived psychological empowerment and professional autonomy.

PubMed

Watkins, Chanell; Hart, Patricia L; Mareno, Nicole

2016-03-01

The first year turnover rate for newly licensed registered nurses is roughly 30% and increases to about 57% in the second year (Twibell et al., 2012). An effective preceptorship has been shown to better facilitate the first year transition (Hodges et al., 2008) and increase retention rates (Pine and Tart, 2007). The purpose of this study was to examine the relationships between newly licensed registered nurses' perceived preceptor role effectiveness, psychological empowerment and professional autonomy. A prospective, cross-sectional, descriptive research design was used. Sixty-nine newly licensed registered nurses were recruited and surveyed. Newly licensed registered nurses were found to have moderately high levels of perceived preceptor role effectiveness, psychological empowerment, and professional autonomy. Preceptor role effectiveness had significant, moderately, positive relationships with professional autonomy and psychological empowerment. There was also a significant relationship found between professional autonomy and psychological empowerment. Results show that preceptor role effectiveness is linked to increased professional autonomy and psychological empowerment. Therefore, effective preceptorships are necessary in easing the newly licensed registered nurse's transition to practice. Strategies to ensure effective preceptorships and enhance the NRLN's transition to practice are proposed. Copyright © 2016 Elsevier Ltd. All rights reserved.

In silico engineering of aggregation-prone recombinant proteins for substrate recognition by the chaperonin GroEL.

PubMed

Kumar, Vipul; Punetha, Ankita; Sundar, Durai; Chaudhuri, Tapan K

2012-01-01

Molecular chaperones appear to have been evolved to facilitate protein folding in the cell through entrapment of folding intermediates on the interior of a large cavity formed between GroEL and its co-chaperonin GroES. They bind newly synthesized or non-native polypeptides through hydrophobic interactions and prevent their aggregation. Some proteins do not interact with GroEL, hence even though they are aggregation prone, cannot be assisted by GroEL for their folding. In this study, we have attempted to engineer these non-substrate proteins to convert them as the substrate for GroEL, without compromising on their function. We have used a computational biology approach to generate mutants of the selected proteins by selectively mutating residues in the hydrophobic patch, similar to GroES mobile loop region that are responsible for interaction with GroEL, and compared with the wild counterparts for calculation of their instability and aggregation propensities. The energies of the newly designed mutants were computed through molecular dynamics simulations. We observed increased aggregation propensity of some of the mutants formed after replacing charged amino acid residues with hydrophobic ones in the well defined hydrophobic patch, raising the possibility of their binding ability to GroEL. The newly generated mutants may provide potential substrates for Chaperonin GroEL, which can be experimentally generated and tested for their tendency of aggregation, interactions with GroEL and the possibility of chaperone-assisted folding to produce functional proteins.

Applying core principles to the design and evaluation of the 'Take Charge. Take the Test' campaign: what worked and lessons learned.

PubMed

Fraze, J L; Uhrig, J D; Davis, K C; Taylor, M K; Lee, N R; Spoeth, S; Robinson, A; Smith, K; Johnston, J; McElroy, L

2009-09-01

To describe the application of seven core principles to the design and evaluation of a human immunodeficiency virus (HIV) testing social marketing campaign as a case study example. The Centers for Disease Control and Prevention (CDC) used a structured social marketing approach, informed by the Ecological Model, the Theory of Planned Behaviour and the Health Belief Model, to develop and evaluate a two-city campaign with print, radio and outdoor advertising; HIV telephone hotlines; an HIV website; community partnerships; and events to promote information seeking and HIV testing. The CDC applied seven core principles to design and evaluate the campaign, including formative research, the use of behavioural theories, audience segmentation, message design and pretesting, channel selection, process evaluation and outcome evaluation. Over 200 partners in both cities contributed significantly to campaign efforts. Key informant interviews indicated that, due to increased coordination, city infrastructures for HIV testing improved. More than 9600 individuals attended campaign events in both cities, with 1492 rapid HIV tests administered and 14 newly-identified HIV individuals. Overall, event attendees responded positively to campaign materials and events, and free HIV testing opportunities. The campaign significantly increased information-seeking behaviours in the form of hotline calls and web searches. Audience reaction and receptivity to the final campaign materials was very high. Exposure to campaign messages was associated with increases in key knowledge items, intentions to get tested, and peer-to-peer communication. The seven core principles, including formative research, behavioural theories and extensive partnerships, acted synergistically to help a campaign reach its target audience with compelling, relevant messages and motivate them to seek information and get an HIV test. Rapid testing removes many barriers by providing a testing process that can be accessed and acted upon quickly in response to media exposure. Findings suggest that modifying the campaign in future implementations to encourage the target audience to attend and participate in rapid testing events, while expanding the number and reach of such events, may have considerable potential to measurably increase testing behaviours.

Competence of newly qualified registered nurses from a nursing college.

PubMed

Morolong, B G; Chabeli, M M

2005-05-01

The South African education and training system, through its policy of outcomes-based education and training, has made competency a national priority. In compliance to this national requirement of producing competent learners, the South African Nursing Council (1999 B) require that the beginner professional nurse practitioners and midwives have the necessary knowledge, skills, attitudes and values which will enable them to render efficient professional service. The health care system also demands competent nurse practitioners to ensure quality in health care. In the light of competency being a national priority and a statutory demand, the research question that emerges is, how competent are the newly qualified registered nurses from a specific nursing college in clinical nursing education? A quantitative, non-experimental contextual design was used to evaluate the competence of newly qualified registered nurses from a specific nursing college. The study was conducted in two phases. The first phase dealt with the development of an instrument together with its manual through the conceptualisation process. The second phase focused on the evaluation of the competency of newly qualified nurses using the instrument based on the steps of the nursing process. A pilot study was conducted to test the feasibility of the items of the instrument. During the evaluation phase, a sample of twenty-six newly qualified nurses was selected by simple random sampling from a target population of thirty-six newly qualified registered nurses. However, six participants withdrew from the study. Data was collected in two general hospitals where the newly qualified registered nurses were working. Observation and questioning were used as data collection techniques in accordance with the developed instrument. Measures were taken to ensure internal validity and reliability of the results. To protect the rights of the participants, the researcher adhered to DENOSA'S (1998:2.2.1) ethical standards of research. A descriptive statistical method of data analysis was used in this study. Findings revealed that newly qualified registered nurses were not competent. The highest score obtained was 51% and the lowest score was 22% with an average score of 34.05%. The results concerning the implementation of the phases of the nursing process indicated that participants were fairly competent in terms of knowledge, skills, attitudes and values of assessment. Participants had very little knowledge of nursing diagnosis and were not competent on the skills of diagnosis. Participants lacked basic knowledge, skills, attitudes and values of the nursing process. They lacked critical thinking skills in their approach to providing quality patient care. The recommendations of the study relate to improving the system of clinical accompaniment, reviewing the clinical facilities where learners are allocated, reviewing the implementation of the curriculum, the methods of teaching and the quality assurance mechanisms that are in place. Further research is recommended on competence of newly qualified registered nurses at other nursing colleges or similar context.

Direct Reading Particle Counters: Calibration Verification and Multiple Instrument Agreement via Bump Testing

DOE Office of Scientific and Technical Information (OSTI.GOV)

Jankovic, John; Zontek, Tracy L.; Ogle, Burton R.

We examined the calibration records of two direct reading instruments designated as condensation particle counters in order to determine the number of times they were found to be out of tolerance at annual manufacturer's recalibration. For both instruments were found to be out of tolerance more times than within tolerance. And, it was concluded that annual calibration alone was insufficient to provide operational confidence in an instrument's response. Thus, a method based on subsequent agreement with data gathered from a newly calibrated instrument was developed to confirm operational readiness between annual calibrations, hereafter referred to as bump testing. The methodmore » consists of measuring source particles produced by a gas grille spark igniter in a gallon-size jar. Sampling from this chamber with a newly calibrated instrument to determine the calibrated response over the particle concentration range of interest serves as a reference. Agreement between this reference response and subsequent responses at later dates implies that the instrument is performing as it was at the time of calibration. Side-by-side sampling allows the level of agreement between two or more instruments to be determined. This is useful when simultaneously collected data are compared for differences, i.e., background with process aerosol concentrations. A reference set of data was obtained using the spark igniter. The generation system was found to be reproducible and suitable to form the basis of calibration verification. Finally, the bump test is simple enough to be performed periodically throughout the calibration year or prior to field monitoring.« less

Direct Reading Particle Counters: Calibration Verification and Multiple Instrument Agreement via Bump Testing

DOE PAGES

Jankovic, John; Zontek, Tracy L.; Ogle, Burton R.; ...

2015-01-27

We examined the calibration records of two direct reading instruments designated as condensation particle counters in order to determine the number of times they were found to be out of tolerance at annual manufacturer's recalibration. For both instruments were found to be out of tolerance more times than within tolerance. And, it was concluded that annual calibration alone was insufficient to provide operational confidence in an instrument's response. Thus, a method based on subsequent agreement with data gathered from a newly calibrated instrument was developed to confirm operational readiness between annual calibrations, hereafter referred to as bump testing. The methodmore » consists of measuring source particles produced by a gas grille spark igniter in a gallon-size jar. Sampling from this chamber with a newly calibrated instrument to determine the calibrated response over the particle concentration range of interest serves as a reference. Agreement between this reference response and subsequent responses at later dates implies that the instrument is performing as it was at the time of calibration. Side-by-side sampling allows the level of agreement between two or more instruments to be determined. This is useful when simultaneously collected data are compared for differences, i.e., background with process aerosol concentrations. A reference set of data was obtained using the spark igniter. The generation system was found to be reproducible and suitable to form the basis of calibration verification. Finally, the bump test is simple enough to be performed periodically throughout the calibration year or prior to field monitoring.« less

A wireless object location detector enabling people with developmental disabilities to control environmental stimulation through simple occupational activities with Nintendo Wii Balance Boards.

PubMed

Shih, Ching-Hsiang; Chang, Man-Ling

2012-01-01

The latest researches have adopted software technology, turning the Nintendo Wii Balance Board into a high performance standing location detector with a newly developed standing location detection program (SLDP). This study extended SLDP functionality to assess whether two people with developmental disabilities would be able to actively perform simple occupational activities by controlling their favorite environmental stimulation using Nintendo Wii Balance Boards and SLDP software. An ABAB design was adopted in this study to perform the tests. The test results showed that, during the intervention phases, both participants significantly increased their target response (i.e. simple occupational activity) to activate the control system to produce environmental stimulation. The practical and developmental implications of the findings are discussed. Copyright © 2012 Elsevier Ltd. All rights reserved.

Structural response of existing spatial truss roof construction based on Cosserat rod theory

NASA Astrophysics Data System (ADS)

Miśkiewicz, Mikołaj

2018-04-01

Paper presents the application of the Cosserat rod theory and newly developed associated finite elements code as the tools that support in the expert-designing engineering practice. Mechanical principles of the 3D spatially curved rods, dynamics (statics) laws, principle of virtual work are discussed. Corresponding FEM approach with interpolation and accumulation techniques of state variables are shown that enable the formulation of the C0 Lagrangian rod elements with 6-degrees of freedom per node. Two test examples are shown proving the correctness and suitability of the proposed formulation. Next, the developed FEM code is applied to assess the structural response of the spatial truss roof of the "Olivia" Sports Arena Gdansk, Poland. The numerical results are compared with load test results. It is shown that the proposed FEM approach yields correct results.

The Effect of Half-year Education to Cultivate Dialogical Thinking Ability for Students in the Electrical Engineering Majors

NASA Astrophysics Data System (ADS)

Nakano, Mika; Takahara, Kenji; Kajiwara, Toshinori

This paper describes the effect of curriculum for communication ability, “Communication Theory I”, newly started in Fukuoka Institute of Technology in 2007. The purpose of this half-year course was to develop self-awareness and to improve interpersonal relationship through dialog. The program was designed, based on the Process of attitude change of students through dialogue. In the class, students were encouraged to take active role in discussion, constructing one's own argument and refuting others'. Emphasis was also placed on giving the students the opportunity to evaluate other students' discussion. Results showed differences in pre-test-post-test comparisons, confirming that learning environment for discussion could result in conceptual change for students. Further interview analyses and analyses of speech data helped to clarify what was learned through debate.

Mobile Web and Accessibility

NASA Astrophysics Data System (ADS)

Hori, Masahiro; Kato, Takashi

While focusing on the human-computer interaction side of the Web content delivery, this article discusses problems and prospects of the mobile Web and Web accessibility in terms of what lessons and experiences we have gained from Web accessibility and what they can say about the mobile Web. One aim is to draw particular attention to the importance of explicitly distinguishing between perceptual and cognitive aspects of the users’ interactions with the Web. Another is to emphasize the increased importance of scenario-based evaluation and remote testing for the mobile Web where the limited screen space and a variety of environmental factors of mobile use are critical design issues. A newly devised inspection type of evaluation method that focuses on the perceptual-cognitive distinction of accessibility and usability issues is presented as a viable means of scenario-based, remote testing for the Web.

Development of Electric Power Units Driven by Waste Heat

NASA Astrophysics Data System (ADS)

Inoue, Naoyuki; Takeuchi, Takao; Kaneko, Atsushi; Uchimura, Tomoyuki; Irie, Kiichi; Watanabe, Hiroyoshi

For the development of a simple and compact power generator driven by waste heat, working fluids and an expander were studied, then a practical electric power unit was put to test. Many working fluids were calculated with the low temperature power cycle (evaporated at 77°C, condensed at 42°C),and TFE,R123,R245fa were selected to be suitable for the cycle. TFE(Trifluoroethanol CF3CH2OH) was adopted to the actual power generator which was tested. A radial turbine was adopted as an expander, and was newly designed and manufactured for working fluid TFE. The equipment was driven by hot water as heat source and cooling water as cooling source, and generated power was connected with electric utility. Characteristics of the power generating cycle and characteristics of the turbine were obtained experimentally.

CoMFA and CoMSIA 3D-QSAR studies on S(6)-(4-nitrobenzyl)mercaptopurine riboside (NBMPR) analogs as inhibitors of human equilibrative nucleoside transporter 1 (hENT1).

PubMed

Gupte, Amol; Buolamwini, John K

2009-01-15

3D-QSAR (CoMFA and CoMSIA) studies were performed on human equlibrative nucleoside transporter (hENT1) inhibitors displaying K(i) values ranging from 10,000 to 0.7nM. Both CoMFA and CoMSIA analysis gave reliable models with q2 values >0.50 and r2 values >0.92. The models have been validated for their stability and robustness using group validation and bootstrapping techniques and for their predictive abilities using an external test set of nine compounds. The high predictive r2 values of the test set (0.72 for CoMFA model and 0.74 for CoMSIA model) reveals that the models can prove to be a useful tool for activity prediction of newly designed nucleoside transporter inhibitors. The CoMFA and CoMSIA contour maps identify features important for exhibiting good binding affinities at the transporter, and can thus serve as a useful guide for the design of potential equilibrative nucleoside transporter inhibitors.

Progress towards the Advanced Cryogenic Gas Stopper at NSCL

NASA Astrophysics Data System (ADS)

Lund, Kasey; Bollen, Georg; Villiari, Antonio; Lawton, Don; Morrissey, Dave; Otterson, Jack; Ringle, Ryan; Schwarz, Stefan; Sumithrarachchi, Chandana; Yurkon, John; Advanced Cryogenic Gas Stopper Design Team

2016-09-01

Beam stopping is the key to performing experiments with low-energy beams of rare isotopes produced by projectile fragmentation. Linear gas stoppers filled with helium have become reliable tools to accomplish this task. Further developments are underway to maximize efficiency and beam rate capability in order to increase scientific reach. Improvements include increasing extraction efficiency, lowering decay losses due to slow transport time, reducing molecular combination of the isotope of interest with background impurity gases, and minimizing space charge effects. The ACGS under construction at NSCL is designed to increase performance by overcoming some of the more common issues. The use of a 4-phase RF wire carpet to generate an electrical traveling wave speeds up the ion transport times. Cryogenic cooling of the helium gas chamber reduces molecular ion information. A geometry that puts the RF carpet in the mid-plane of the gas stopper alleviates space charge effects. Prototype testing of important ACGS components has been completed, specifically ion transport tests of the newly designed RF wire carpets. Transport efficiencies up to 95% were demonstrated as well as transport speeds up to 100 m/s. RC104100.7301.

Evaluating the Acceptability and Feasibility of Project ACCEPT: An Intervention for Youth Newly Diagnosed with HIV

ERIC Educational Resources Information Center

Hosek, Sybil G.; Lemos, Diana; Harper, Gary W.; Telander, Kyle

2011-01-01

Given the potential for negative psychosocial and medical outcomes following an HIV diagnosis, Project ACCEPT, a 12-session behavioral intervention, was developed and pilot-tested for youth (aged 16-24) newly diagnosed with HIV. Fifty participants recently diagnosed with HIV were enrolled from 4 sites selected through the Adolescent Medicine…

An Extended Case Study Methoology for Investigating Influence of Cultural, Organizational, and Automation Factors on Human-Automation Trust

NASA Technical Reports Server (NTRS)

Koltai, Kolina Sun; Ho, Nhut; Masequesmay, Gina; Niedober, David; Skoog, Mark; Johnson, Walter; Cacanindin, Artemio

2014-01-01

This paper discusses a case study that examined the influence of cultural, organizational and automation capability upon human trust in, and reliance on, automation. In particular, this paper focuses on the design and application of an extended case study methodology, and on the foundational lessons revealed by it. Experimental test pilots involved in the research and development of the US Air Forces newly developed Automatic Ground Collision Avoidance System served as the context for this examination. An eclectic, multi-pronged approach was designed to conduct this case study, and proved effective in addressing the challenges associated with the cases politically sensitive and military environment. Key results indicate that the system design was in alignment with pilot culture and organizational mission, indicating the potential for appropriate trust development in operational pilots. These include the low-vulnerabilityhigh risk nature of the pilot profession, automation transparency and suspicion, system reputation, and the setup of and communications among organizations involved in the system development.

Design of Ski Boots for Alpine Ski Racing Based on Leg Frame of the Skier

NASA Astrophysics Data System (ADS)

Suzuki, Soichiro; Hayashi, Sueyoshi

A ski boot is important to make progress in ski turning technique as an interface between a skier and a ski. Especially in alpine ski races, suitability of design of the boots for racers becomes more important to achieve accurate and quick lean of the leg in ski turns. This study is aimed at building a new design concept of a ski boot that can improve the results of alpine ski races. In this paper, new design of an upper shell of a ski boot that was adjusted to the features of the frame of alpine ski racers was experimentally examined. As a result, it was demonstrated that a front and a rear part of the upper shell of a ski boot should be separately adjusted to the length of a shank of each player for well-balanced quick lean of the leg in the ski turn. Finally, the effect of new design of an upper shell was examined in giant slalom and slalom tests by Japanese alpine ski racers of the first rank. Consequently, the results showed that lean angle during turns was increased and finish time was shortened when the skiers wore the newly designed boots.

Study of cognitive functions in newly diagnosed cases of subclinical and clinical hypothyroidism.

PubMed

Sharma, Kirti; Behera, Joshil Kumar; Sood, Sushma; Rajput, Rajesh; Satpal; Praveen, Prashant

2014-01-01

Hypothyroidism is associated with significant neurocognitive deficits because hypothyroidism prevents the brain from adequately sustaining the energy consuming processes needed for neurotransmission, memory, and other higher brain functions. Hence, the study was done to assess the cognitive functions of newly diagnosed subclinical and clinical hypothyroid patients by evoked response potential P300. 75 patients each of newly diagnosed subclinical and clinical hypothyroid patients attending endocrinology clinic and 75 healthy age and sex matched euthyroid controls were considered for the study. P300 was recorded with Record Medicare System Polyrite, Chandigarh using auditory "oddball paradigm". The data was analyzed using ANOVA followed by post Tukey's test. Newly diagnosed clinical hypothyroid patients showed a significant increase in P300 latency compared to control (P < 0.05) and subclinical cases (P < 0.01) while there was no significant difference between the P300 latency of subclinical cases and control group. Also, there was no significant difference in P300 amplitude among the three groups. P300 latency in case of newly diagnosed hypothyroid clinical cases is significantly increased compared to newly diagnosed subclinical cases and control.

A Disposable Tear Glucose Biosensor—Part 2: System Integration and Model Validation

PubMed Central

La Belle, Jeffrey T.; Bishop, Daniel K.; Vossler, Stephen R.; Patel, Dharmendra R.; Cook, Curtiss B.

2010-01-01

Background We presented a concept for a tear glucose sensor system in an article by Bishop and colleagues in this issue of Journal of Diabetes Science and Technology. A unique solution to collect tear fluid and measure glucose was developed. Individual components were selected, tested, and optimized, and system error modeling was performed. Further data on prototype testing are now provided. Methods An integrated fluidics portion of the prototype was designed, cast, and tested. A sensor was created using screen-printed sensors integrated with a silicone rubber fluidics system and absorbent polyurethane foam. A simulated eye surface was prepared using fluid-saturated poly(2-hydroxyethyl methacrylate) sheets, and the disposable prototype was tested for both reproducibility at 0, 200, and 400 μM glucose (n = 7) and dynamic range of glucose detection from 0 to 1000 μM glucose. Results From the replicated runs, an established relative standard deviation of 15.8% was calculated at 200 μM and a lower limit of detection was calculated at 43.4 μM. A linear dynamic range was demonstrated from 0 to 1000 μM with an R2 of 99.56%. The previously developed model predicted a 14.9% variation. This compares to the observed variance of 15.8% measured at 200 μM glucose. Conclusion With the newly designed fluidics component, an integrated tear glucose prototype was assembled and tested. Testing of this integrated prototype demonstrated a satisfactory lower limit of detection for measuring glucose concentration in tears and was reproducible across a physiological sampling range. The next step in the device design process will be initial animal studies to evaluate the current prototype for factors such as eye irritation, ease of use, and correlation with blood glucose. PMID:20307390

A disposable tear glucose biosensor-part 2: system integration and model validation.

PubMed

La Belle, Jeffrey T; Bishop, Daniel K; Vossler, Stephen R; Patel, Dharmendra R; Cook, Curtiss B

2010-03-01

We presented a concept for a tear glucose sensor system in an article by Bishop and colleagues in this issue of Journal of Diabetes Science and Technology. A unique solution to collect tear fluid and measure glucose was developed. Individual components were selected, tested, and optimized, and system error modeling was performed. Further data on prototype testing are now provided. An integrated fluidics portion of the prototype was designed, cast, and tested. A sensor was created using screen-printed sensors integrated with a silicone rubber fluidics system and absorbent polyurethane foam. A simulated eye surface was prepared using fluid-saturated poly(2-hydroxyethyl methacrylate) sheets, and the disposable prototype was tested for both reproducibility at 0, 200, and 400 microM glucose (n = 7) and dynamic range of glucose detection from 0 to 1000 microM glucose. From the replicated runs, an established relative standard deviation of 15.8% was calculated at 200 microM and a lower limit of detection was calculated at 43.4 microM. A linear dynamic range was demonstrated from 0 to 1000 microM with an R(2) of 99.56%. The previously developed model predicted a 14.9% variation. This compares to the observed variance of 15.8% measured at 200 microM glucose. With the newly designed fluidics component, an integrated tear glucose prototype was assembled and tested. Testing of this integrated prototype demonstrated a satisfactory lower limit of detection for measuring glucose concentration in tears and was reproducible across a physiological sampling range. The next step in the device design process will be initial animal studies to evaluate the current prototype for factors such as eye irritation, ease of use, and correlation with blood glucose. (c) 2010 Diabetes Technology Society.

Hyperthermal Environments Simulator for Nuclear Rocket Engine Development

NASA Technical Reports Server (NTRS)

Litchford, Ron J.; Foote, John P.; Clifton, W. B.; Hickman, Robert R.; Wang, Ten-See; Dobson, Christopher C.

2011-01-01

An arc-heater driven hyperthermal convective environments simulator was recently developed and commissioned for long duration hot hydrogen exposure of nuclear thermal rocket materials. This newly established non-nuclear testing capability uses a high-power, multi-gas, wall-stabilized constricted arc-heater to produce hightemperature pressurized hydrogen flows representative of nuclear reactor core environments, excepting radiation effects, and is intended to serve as a low-cost facility for supporting non-nuclear developmental testing of hightemperature fissile fuels and structural materials. The resulting reactor environments simulator represents a valuable addition to the available inventory of non-nuclear test facilities and is uniquely capable of investigating and characterizing candidate fuel/structural materials, improving associated processing/fabrication techniques, and simulating reactor thermal hydraulics. This paper summarizes facility design and engineering development efforts and reports baseline operational characteristics as determined from a series of performance mapping and long duration capability demonstration tests. Potential follow-on developmental strategies are also suggested in view of the technical and policy challenges ahead. Keywords: Nuclear Rocket Engine, Reactor Environments, Non-Nuclear Testing, Fissile Fuel Development.

Advanced Stirling Convertor Dual Convertor Controller Testing at NASA Glenn Research Center in the Radioisotope Power Systems System Integration Laboratory

NASA Technical Reports Server (NTRS)

Dugala, Gina M.; Taylor, Linda M.; Bell, Mark E.; Dolce, James L.; Fraeman, Martin; Frankford, David P.

2015-01-01

NASA Glenn Research Center developed a nonnuclear representation of a Radioisotope Power System (RPS) consisting of a pair of Advanced Stirling Convertors (ASCs), Dual Convertor Controller (DCC) EMs (engineering models) 2 and 3, and associated support equipment, which were tested in the Radioisotope Power Systems System Integration Laboratory (RSIL). The DCC was designed by the Johns Hopkins University Applied Physics Laboratory (JHU/APL) to actively control a pair of ASCs. The first phase of testing included a Dual Advanced Stirling Convertor Simulator (DASCS), which was developed by JHU/APL and simulates the operation and electrical behavior of a pair of ASCs in real time via a combination of hardware and software. RSIL provides insight into the electrical interactions between a representative radioisotope power generator, its associated control schemes, and realistic electric system loads. The first phase of integration testing included the following spacecraft bus configurations: capacitive, battery, and super-capacitor. A load profile, created based on data from several missions, tested the RPS's and RSIL's ability to maintain operation during load demands above and below the power provided by the RPS. The integration testing also confirmed the DCC's ability to disconnect from the spacecraft when the bus voltage dipped below 22 volts or exceeded 36 volts. Once operation was verified with the DASCS, the tests were repeated with actual operating ASCs. The goal of this integration testing was to verify operation of the DCC when connected to a spacecraft and to verify the functionality of the newly designed RSIL. The results of these tests are presented in this paper.

The magnetohydrodynamics coal-fired flow facility

NASA Astrophysics Data System (ADS)

1990-12-01

The purpose of this report is to provide the status of a multi-task research and development program in coal fired MHD/steam combined cycle power production (more detailed information on specific topics is presented in topical reports). Current emphasis is on developing technology for the Steam Bottoming Cycle Program. The approach being taken is to design test components that simulate the most important process variables, such as gas temperature, chemical composition, tube metal temperature, particulate loading, etc., to gain test data needed for scale-up to larger size components. This quarter, a 217 hour coal-fired long-duration test was completed as part of the Proof-of-Concept (POC) test program. The aggregate test time is now 1512 hours of a planned 2000 hours on Eastern coal. The report contains results of testing the newly installed automatic ash/seed handling system and the high pressure sootblower system. The conceptual design for the modifications to the coal processing system to permit operation with Western coal is presented. Results of analysis of superheater test module tube removed after 500 hours of coal-fired testing are summarized. The status of the environmental program is reported. Pollutant measurements from remote monitoring trailers that give the dispersion of stack emissions are presented. Results of advanced measurement systems operated by both UTSI and Mississippi State University during the POC test are summarized. Actions to prepare for the installation of a 20MW(sub t) prototype of the TRW slag rejection combustor first stage are discussed. Contract management and administrative actions completed during the quarter are included.

Principles in sampling design, lessons, and recommendations from a multi-year, multi-port surveillance program in Lake Superior

EPA Science Inventory

We evaluated a pilot aquatic invasive species (AIS) early detection monitoring program in Lake Superior that was designed to detect newly-introduced fishes. We established survey protocols for three major ports (Duluth-Superior, Sault Ste. Marie, Thunder Bay), and designed an ada...

Comparing two methods of education (virtual versus traditional) on learning of Iranian dental students: a post-test only design study.

PubMed

Moazami, Fariborz; Bahrampour, Ehsan; Azar, Mohammad Reza; Jahedi, Farzad; Moattari, Marzieh

2014-03-05

The importance of using technologies such as e-learning in different disciplines is discussed in the literature. Researchers have measured the effectiveness of e-learning in a number of fields.Considering the lack of research on the effectiveness of online learning in dental education particularly in Iran, the advantages of these learning methods and the positive university atmosphere regarding the use of online learning. This study, therefore, aims to compare the effects of two methods of teaching (virtual versus traditional) on student learning. This post-test only design study approached 40, fifth year dental students of Shiraz University of Medical Sciences. From this group, 35 students agreed to participate. These students were randomly allocated into two groups, experimental (virtual learning) and comparison (traditional learning). To ensure similarity between groups, we compared GPAs of all participants by the Mann-Whitney U test (P > 0.05). The experimental group received a virtual learning environment courseware package specifically designed for this study, whereas the control group received the same module structured in a traditional lecture form. The virtual learning environment consisted of online and offline materials. Two identical valid, reliable post-tests that consisted of 40 multiple choice questions (MCQs) and 4 essay questions were administered immediately (15 min) after the last session and two months later to assess for knowledge retention. Data were analyzed by SPSS version 20. A comparison of the mean knowledge score of both groups showed that virtual learning was more effective than traditional learning (effect size = 0.69). The newly designed virtual learning package is feasible and will result in more effective learning in comparison with lecture-based training. However further studies are needed to generalize the findings of this study.

Expansion of the E138A mutation in newly diagnosed HIV-infected patients in Gran Canaria.

PubMed

Chamizo, Francisco; Gilarranz, Raúl; Tosco, Tomás; Carrillo, Deyanira; Holguín, África; Santana, Évora; Pérez-Arellano, Jose Luís; Hernández, Michele; Francés, Adela; Cárdenes, Miguel Ángel; Zarzalejos, Jose María; Pena-López, María José

2016-09-01

Molecular epidemiology allows us to know local HIV transmission and to design strategies of prevention. We studied 25 HIV newly diagnosed patients with the E138A mutation since the year 2010. Most transmission networks involved young and promiscuous men who have sex with men. Recent infection was only documented in patients grouped into the smaller clusters. Copyright © 2016 Elsevier Inc. All rights reserved.

Attrition from HIV Testing to Antiretroviral Therapy Initiation among Patients Newly Diagnosed with HIV in Haiti

PubMed Central

NOEL, Edva; ESPERANCE, Morgan; MCLAUGHLIN, Megan; BERTRAND, Rachel; DEVIEUX, Jessy; SEVERE, Patrice; MARCELIN, Abdias; NICOTERA, Janet; DELCHER, Chris; GRISWOLD, Mark; MEREDITH, Genevive; PAPE, Jean William; KOENIG, Serena P

2013-01-01

Objective We report rates and risk factors for attrition in the first cohort of patients followed through all stages from HIV testing to ART initiation. Design Cohort study of all patients diagnosed with HIV between January and June, 2009. Methods We calculated the proportion of patients who completed CD4 cell counts and initiated ART or remained in pre-ART care during two years of follow-up, and assessed predictors of attrition. Results Of 1,427 patients newly diagnosed with HIV, 680 (48%) either initiated ART or were retained in pre-ART care for the subsequent two years. One thousand eighty-three patients (76%) received a CD4 cell count and 973 (90%) returned for result; 297 (31%) had CD4 cell count < 200 cells/μl and of these, 256 (86%) initiated ART. Among 429 patients with CD4 > 350 cells/μl, 215 (50%) started ART or were retained in pre-ART care. Active TB was associated with lower odds of attrition prior to CD4 cell count (OR: 0.08; 95% CI: 0.03–0.25) but also higher odds of attrition prior to ART initiation (OR: 2.46; 95% CI: 1.29–4.71). Lower annual income (≤ $US125) was associated with higher odds of attrition prior to CD4 cell count (OR 1.65; 95% CI: 1.25–2.19), and prior to ART initiation among those with CD4 cell count > 350 cells/μl (OR: 1.74; 95% CI: 1.20–2.52). After tracking patients through a national database, the retention rate increased to only 57%. Conclusion Fewer than half of patients newly diagnosed with HIV initiate ART or remain in pre-ART care for two years in a clinic providing comprehensive services. Additional efforts to improve retention in pre-ART are critically needed. PMID:23254154

Replacement Windows Define the Newly Renovated Fiterman Hall.

ERIC Educational Resources Information Center

Ladesich, Jim

2000-01-01

Explores the planning and testing involved in successfully replacing windows in a corporate office building converted into an academic building. Inspection procedures and performance testing are examined. (GR)

Experimental analysis of the sheet metal forming behavior of newly developed press hardening steels

NASA Astrophysics Data System (ADS)

Meza-García, Enrique; Kräusel, Verena; Landgrebe, Dirk

2018-05-01

The aim of this work was the characterization of the newly developed press hardening sheet alloys 1800 PHS and 2000 PHS developed by SSAB with regard to their hot forming behavior on the basis of the experimental determination of relevant mechanical and technological properties. For this purpose conventional and non-conventional sheet metal testing methods were used. To determine the friction coefficient, the strip drawing test was applied, while the deep drawing cup test was used to determine the maximum draw depth. Finally, a V-bending test was carried out to evaluate the springback behavior of the investigated alloys by varying the blank temperature and quenching media. This work provides a technological guideline for the production of press hardened sheet parts made of these investigated sheet metals.

Null alleles are ubiquitous at microsatellite loci in the Wedge Clam (Donax trunculus)

PubMed Central

Cuesta, Jose Antonio; Drake, Pilar; Macpherson, Enrique; Bernatchez, Louis

2017-01-01

Recent studies have reported an unusually high frequency of nonamplifying alleles at microsatellite loci in bivalves. Null alleles have been associated with heterozygous deficits in many studies. While several studies have tested for its presence using different analytical tools, few have empirically tested for its consequences in estimating population structure and differentiation. We characterised 16 newly developed microsatellite loci and show that null alleles are ubiquitous in the wedge clam, Donax trunculus. We carried out several tests to demonstrate that the large heterozygous deficits observed in the newly characterised loci were most likely due to null alleles. We tested the robustness of microsatellite genotyping for population assignment by showing that well-recognised biogeographic regions of the south Atlantic and south Mediterranean coast of Spain harbour genetically different populations. PMID:28439464

Newly Designed Break-Apart and ASPL-TFE3 Dual-Fusion FISH Assay Are Useful in Diagnosing Xp11.2 Translocation Renal Cell Carcinoma and ASPL-TFE3 Renal Cell Carcinoma

PubMed Central

Chen, Xiancheng; Yang, Yang; Gan, Weidong; Xu, Linfeng; Ye, Qing; Guo, Hongqian

2015-01-01

Abstract The diagnosis of Xp11.2 translocation renal cell carcinoma (tRCC), which relies on morphology and immunohistochemistry (IHC), is often either missed in the diagnosis or misdiagnosed. To improve the accuracy of diagnosis of Xp11.2 tRCC and ASPL-TFE3 renal cell carcinoma (RCC), we investigated newly designed fluorescence in situ hybridization (FISH) probes (diagnostic accuracy study). Based on the genetic characteristics of Xp11.2 tRCC and the ASPL-TFE3 RCC, a new break-apart TFE3 FISH probe and an ASPL-TFE3 dual-fusion FISH probe were designed and applied to 65 patients with RCC who were <45 years old or showed suspicious microscopic features of Xp11.2 tRCC in our hospital. To test the accuracy of the probes, we further performed reverse transcriptase–polymerase chain reaction (PCR) on 8 cases for which frozen tissues were available. Among the 65 cases diagnosed with RCC, TFE3 IHC was positive in 24 cases. Twenty-two cases were confirmed as Xp11.2 tRCC by break-apart TFE3 FISH, and 6 of these cases were further diagnosed as ASPL-TFE3 RCC by ASPL-TFE3 dual-fusion FISH detection. Importantly, reverse transcriptase–PCR showed concordant results with the results of FISH assay in the 8 available frozen cases. The break-apart and ASPL-TFE3 dual-fusion FISH assay can accurately detect the translocation of the TFE3 gene and ASPL-TFE3 fusion gene and can thus serve as a valid complementary method for diagnosing Xp11.2 tRCC and ASPL-TFE3 RCC. PMID:25984679

Newly designed break-apart and ASPL-TFE3 dual-fusion FISH assay are useful in diagnosing Xp11.2 translocation renal cell carcinoma and ASPL-TFE3 renal cell carcinoma: a STARD-compliant article.

PubMed

Chen, Xiancheng; Yang, Yang; Gan, Weidong; Xu, Linfeng; Ye, Qing; Guo, Hongqian

2015-05-01

The diagnosis of Xp11.2 translocation renal cell carcinoma (tRCC), which relies on morphology and immunohistochemistry (IHC), is often either missed in the diagnosis or misdiagnosed. To improve the accuracy of diagnosis of Xp11.2 tRCC and ASPL-TFE3 renal cell carcinoma (RCC), we investigated newly designed fluorescence in situ hybridization (FISH) probes (diagnostic accuracy study).Based on the genetic characteristics of Xp11.2 tRCC and the ASPL-TFE3 RCC, a new break-apart TFE3 FISH probe and an ASPL-TFE3 dual-fusion FISH probe were designed and applied to 65 patients with RCC who were <45 years old or showed suspicious microscopic features of Xp11.2 tRCC in our hospital. To test the accuracy of the probes, we further performed reverse transcriptase-polymerase chain reaction (PCR) on 8 cases for which frozen tissues were available.Among the 65 cases diagnosed with RCC, TFE3 IHC was positive in 24 cases. Twenty-two cases were confirmed as Xp11.2 tRCC by break-apart TFE3 FISH, and 6 of these cases were further diagnosed as ASPL-TFE3 RCC by ASPL-TFE3 dual-fusion FISH detection. Importantly, reverse transcriptase-PCR showed concordant results with the results of FISH assay in the 8 available frozen cases.The break-apart and ASPL-TFE3 dual-fusion FISH assay can accurately detect the translocation of the TFE3 gene and ASPL-TFE3 fusion gene and can thus serve as a valid complementary method for diagnosing Xp11.2 tRCC and ASPL-TFE3 RCC.

Underutilization of BRCA1/2 testing to guide breast cancer treatment: black and Hispanic women particularly at risk

PubMed Central

Levy, Douglas E.; Byfield, Stacey D.; Comstock, Catherine B.; Garber, Judy E.; Syngal, Sapna; Crown, William H.; Shields, Alexandra E.

2013-01-01

Purpose Women with early-onset (age ≤40) breast cancer are at high risk of carrying deleterious mutations in the BRCA1/2 genes; genetic assessment is thus recommended. Knowledge of BRCA1/2 mutation status is useful in guiding treatment decisions. To date, there has been no national study of BRCA1/2 testing among newly diagnosed women. Methods We used administrative data (2004–2007) from a national sample of 14.4 million commercially-insured patients to identify newly-diagnosed, early-onset breast cancer cases among women ages 20–40 (n=1,474). Cox models assessed BRCA1/2 testing, adjusting for covariates and differential lengths of follow-up. Results Overall, 30% of women age ≤40 received BRCA1/2 testing. In adjusted analyses, women of Jewish ethnicity were significantly more likely to be tested (HR=2.83, 95% CI 1.52–5.28), while black women (HR=0.34, 95% 0.18–0.64) and Hispanic women (HR=0.52, 95% CI 0.33–0.81) were significantly less likely to be tested than non-Jewish white women. Those enrolled in an HMO (HR=0.73, 95% CI 0.54–0.99) were significantly less likely to receive BRCA1/2 testing than those POS insurance plans. Testing rates rose sharply for women diagnosed in 2007 compared to 2004. Conclusions In this national sample of newly diagnosed breast cancer patients at high risk for BRCA1/2 mutations, genetic assessment was low, with marked racial differences in testing. PMID:21358336

Intracellular targeting of CD44+ cells with self-assembling, protein only nanoparticles.

PubMed

Pesarrodona, Mireia; Ferrer-Miralles, Neus; Unzueta, Ugutz; Gener, Petra; Tatkiewicz, Witold; Abasolo, Ibane; Ratera, Imma; Veciana, Jaume; Schwartz, Simó; Villaverde, Antonio; Vazquez, Esther

2014-10-01

CD44 is a multifunctional cell surface protein involved in proliferation and differentiation, angiogenesis and signaling. The expression of CD44 is up-regulated in several types of human tumors and particularly in cancer stem cells, representing an appealing target for drug delivery in the treatment of cancer. We have explored here several protein ligands of CD44 for the construction of self-assembling modular proteins designed to bind and internalize target cells. Among five tested ligands, two of them (A5G27 and FNI/II/V) drive the formation of protein-only, ring-shaped nanoparticles of about 14 nm that efficiently bind and penetrate CD44(+) cells by an endosomal route. The potential of these newly designed nanoparticles is evaluated regarding the need of biocompatible nanostructured materials for drug delivery in CD44-linked conditions. Copyright © 2014 Elsevier B.V. All rights reserved.

Patient-centred screening for primary immunodeficiency, a multi-stage diagnostic protocol designed for non-immunologists: 2011 update

PubMed Central

de Vries, E

2012-01-01

Members of the European Society for Immunodeficiencies (ESID) and other colleagues have updated the multi-stage expert-opinion-based diagnostic protocol for non-immunologists incorporating newly defined primary immunodeficiency diseases (PIDs). The protocol presented here aims to increase the awareness of PIDs among doctors working in different fields. Prompt identification of PID is important for prognosis, but this may not be an easy task. The protocol therefore starts from the clinical presentation of the patient. Because PIDs may present at all ages, this protocol is aimed at both adult and paediatric physicians. The multi-stage design allows cost-effective screening for PID of the large number of potential cases in the early phases, with more expensive tests reserved for definitive classification in collaboration with a specialist in the field of immunodeficiency at a later stage. PMID:22132890

Instructional Efficiency of Changing Cognitive Load in an Out-of-School Laboratory

NASA Astrophysics Data System (ADS)

Scharfenberg, Franz-Josef; Bogner, Franz X.

2010-04-01

Our research objective focused on monitoring students' mental effort and cognitive achievement to unveil potential effects of an instructional change in an out-of-school laboratory offering gene technology modules. Altogether, 231 students (12th graders) attended our day-long hands-on module. Within a quasi-experimental design, a treatment group followed the newly developed two-step approach derived from cognitive load theory while a control group applied experimentation in a conventional one-step mode. The difference consisted of additional focused discussions combined with noting students' ideas (Step 1) prior to starting any experimental procedure (Step 2). We monitored mental effort (nine times during the teaching unit) and cognitive achievement (in a pre-post-design with follow-up test). The treatment demonstrated a change in instructional efficiency (by combining mental effort and cognitive achievement data), especially for intrinsically high-loaded students. Conclusions for optimizing individual cognitive load in science teaching were drawn.

SMART-1, Platform Design and Project Status

NASA Astrophysics Data System (ADS)

Sjoberg, F.

SMART-1 is the first of the Small Missions for Advanced Research and Technology (SMART), an element of ESA's Horizons 2000 plan for scientific projects. These missions aim at testing key technologies for future Cornerstone missions. The mission of SMART-1 is the flight demonstration of Electric Primary Propulsion for a scientifically relevant deep space trajectory. More specifically, SMART-1 will be launched into a geostationary transfer orbit and use a single ion thruster to achieve lunar orbit. include: -A modern avionics architecture with a clean-cut control hierarchy -Extensive Failure Detection, Isolation and Recovery (FDIR) capabilities following the control hierarchy of the -An advanced power control and distribution system -A newly developed gimbal mechanism for the orientation of the electric ion thruster The project is currently in the FM AIT phase scheduled for launch in late 2002. The paper will describe the SMART- 1 spacecraft platform design as well as the current project and spacecraft verification status.

Design and evaluation of a single-span bridge using ultra-high performance concrete.

DOT National Transportation Integrated Search

2009-09-01

"Research presented herein describes an application of a newly developed material called Ultra-High Performance Concrete (UHPC) to a : single-span bridge. The two primary objectives of this research were to develop a shear design procedure for possib...

Design and evaluation of a single-span bridge using ultra-high performance concrete.

DOT National Transportation Integrated Search

2009-09-01

Research presented herein describes an application of a newly developed material called Ultra-High Performance Concrete (UHPC) to a : single-span bridge. The two primary objectives of this research were to develop a shear design procedure for possibl...

Importance of regular testing of private drinking water systems in North Carolina.

PubMed

Barros, Nirmalla; Rudo, Kenneth; Shehee, Mina

2014-01-01

North Carolina state laws require that water from newly constructed private wells be tested for chemical and microbiologic contamination, but existing wells are not routinely tested. This commentary highlights the importance of regular testing of all private sources of drinking water.

Spectrographs and Large Telescopes: A Study of Instrumentation

NASA Astrophysics Data System (ADS)

Fica, Haley Diane; Crane, Jeffrey D.; Uomoto, Alan K.; Hare, Tyson

2017-01-01

It is a truth universally acknowledged, that a telescope in possession of a large aperture, must be in want of a high resolution spectrograph. Subsystems of these instruments require testing and upgrading to ensure that they can continue to be scientifically productive and usher in a new era of astronomical research. The Planet Finder Spectrograph (PFS) and Magellan Inamori Kyocera Echelle (MIKE), both on the Magellan II Clay telescope at Las Campanas Observatory, and the Giant Magellan Telescope (GMT) Consortium Large Earth Finder (G-CLEF) are examples of such instruments. Bluer flat field lamps were designed for PFS and MIKE to replace lamps no longer available in order to ensure continued, efficient functionality. These newly designed lamps will result in better flat fielding and calibration of data, and thus result in increased reduction of instrument noise. When it is built and installed in 2022, G-CLEF will be be fed by a tertiary mirror on the GMT. Stepper motors attached to the back of this mirror will be used to correct misalignments in the optical relay system. These motors were characterized to ensure that they function as expected to an accuracy of a few microns. These projects incorporate several key aspects of astronomical instrumentation: designing, building, and testing.

DEVELOPMENT OF THE PRIEST RAPIDS TURBINE UPGRADE PROJECT

DOE Office of Scientific and Technical Information (OSTI.GOV)

DeBolt, Donald; Richmond, Marshall C.; Donelson, Richard K.

The Priest Rapids Dam is located on the Columbia River and is operated by Public Utility District No. 2 of Grant County, WA (GCPUD). In operation since 1959, GCPUD decided that a major upgrade was necessary. As with other hydroelectric facilities on the Columbia River, improving fish passage at Priest Rapids Dam is of great importance for salmon and steelhead populations in the Pacific Northwest. Consequently, GCPUD established the Priest Rapids Turbine Upgrade Project to extend the life of the units, increase efficiency and power production, and improve fish-passage. The Priest Rapids powerhouse is equipped with 10 vertical Kaplan turbinesmore » with runner diameters of 7.21 m operating under net heads varying from 18 m to 27 m. The scope of the project included a design competition involving three turbine manufacturers providing up to two designs for evaluation. Selection of the replacement design was determined by the lowest evaluated price based on model test results conducted at an independent laboratory (Ecole Polytechnique Federale de Lausanne in Lausanne Switzerland) and a biological performance score determined by a newly developed Biological Performance Assessment (BioPA) performed by Pacific Northwest National Laboratory in Richland, WA. In the paper, the hydraulic design challenges are reviewed, in addition to comparisons of designs evaluated during the competitive model test program and biological assessment. The paper also provides a description of the process followed by GCPUD, and how the evaluation criteria influenced the development and the finally selected solution.« less

Development of a Questionnaire to Investigate Study Design Factors Influencing Participation in Gait Rehabilitation Research by People with Stroke: A Brief Report.

PubMed

Patterson, Kara K; Gallant, Nicole; Ormiston, Tracey; Patience, Chad; Whitechurch, Mandy; Mansfield, Avril; Brown, Janet

2015-08-01

The main objective of this study was to evaluate the feasibility of a newly developed questionnaire to assess the influence of study design on participation in gait rehabilitation research in a pilot test with individuals with stroke. A secondary objective was to investigate the relationship between participation in gait rehabilitation research and social and clinical factors of interest after stroke. A questionnaire was developed with expert opinion and guidance from related previous research. The questionnaire was pilot tested in a group of 21 people with stroke, and social and clinical factors (including gait function) were collected. Gait function was assessed using a pressure-sensitive mat; social and clinical characteristics were extracted from patient charts. Correlations were performed to investigate relationships between questionnaire responses and gait function, motor impairment, and chronicity; t-tests were used to examine response differences between people with a caregiver at home and those without. A total of 21 people with stroke completed the questionnaire without difficulty; mean completion time was 7.2 (SD 3.5) minutes, with a range of responses across participants. Borderline significant associations were found between gait function and the number of studies in which a person would participate and between stroke chronicity and the location of studies in which a person would participate. A questionnaire to investigate the influence of study design factors on participation in rehabilitation research is feasible for administration in the post-stroke population and has potential to inform the design of future studies.

Efficient synthesis of new 2,3-dihydrooxazole-spirooxindoles hybrids as antimicrobial agents.

PubMed

Tiwari, Shailendra; Pathak, Poonam; Sagar, Ram

2016-05-15

Two series of new 2,3-dihydrooxazole-spirooxindole derivatives were efficiently synthesized starting from N'-(2-oxoindolin-3-ylidene) benzohydrazide/N'-(2-oxoindolin-3-ylidene)-2-phenoxyacetohydrazide using designed synthetic route. Newly synthesized 2,3-dihydrooxazole-spirooxindole derivatives were screened for their antibacterial and antifungal activity against different pathogenic strain of bacteria and fungi. The minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and minimum fungicidal concentration (MFC) were determined for the test compounds as well as for reference standards. Compounds 4e, 4g, 7g have shown good antibacterial activity whereas compounds 4f, 7b, 7d have displayed better antifungal activity. Copyright © 2016 Elsevier Ltd. All rights reserved.

Seed Placement into Veggie Pods

NASA Image and Video Library

2018-02-27

Veggie Passive Orbital Nutrient Delivery System (PONDS) units are being prepared for seed planting inside a laboratory at the Space Station Processing Facility at NASA's Kennedy Space Center in Florida. Veggie PONDS is a direct follow-on to the Veg-01 and Veg-03 hardware and plant growth validation tests. The primary goal of this newly developed plant growing system, Veggie PONDS, is to demonstrate uniform plant growth. PONDS units have features that are designed to mitigate microgravity effects on water distribution, increase oxygen exchange and provide sufficient room for root zone growth. PONDS is planned for use during Veg-04 and Veg-05 on the International Space Station after the Veggie PONDS Validation flights on SpaceX-14 and OA-9.

Seed Placement into Veggie Pods

NASA Image and Video Library

2018-02-27

Seeds are being planted in Veggie Passive Orbital Nutrient Delivery System (PONDS) units inside a laboratory at the Space Station Processing Facility at NASA’s Kennedy Space Center in Florida. Veggie PONDS is a direct follow-on to the Veg-01 and Veg-03 hardware and plant growth validation tests. The primary goal of this newly developed plant growing system, Veggie PONDS, is to demonstrate uniform plant growth. PONDS units have features that are designed to mitigate microgravity effects on water distribution, increase oxygen exchange and provide sufficient room for root zone growth. PONDS is planned for use during Veg-04 and Veg-05 on the International Space Station after the Veggie PONDS Validation flights on SpaceX-14 and OA-9.

3D Printed Shelby Cobra

ScienceCinema

Love, Lonnie

2018-06-12

ORNL's newly printed 3D Shelby Cobra was showcased at the 2015 NAIAS in Detroit. This "laboratory on wheels" uses the Shelby Cobra design, celebrating the 50th anniversary of this model and honoring the first vehicle to be voted a national monument. The Shelby was printed at the Department of Energy’s Manufacturing Demonstration Facility at ORNL using the BAAM (Big Area Additive Manufacturing) machine and is intended as a “plug-n-play” laboratory on wheels. The Shelby will allow research and development of integrated components to be tested and enhanced in real time, improving the use of sustainable, digital manufacturing solutions in the automotive industry.

P80 SRM low torque flex-seal development - thermal and chemical modeling of molding process

NASA Astrophysics Data System (ADS)

Descamps, C.; Gautronneau, E.; Rousseau, G.; Daurat, M.

2009-09-01

The development of the flex-seal component of the P80 nozzle gave the opportunity to set up new design and manufacturing process methods. Due to the short development lead time required by VEGA program, the usual manufacturing iterative tests work flow, which is usually time consuming, had to be enhanced in order to use a more predictive approach. A newly refined rubber vulcanization description was built up and identified on laboratory samples. This chemical model was implemented in a thermal analysis code. The complete model successfully supports the manufacturing processes. These activities were conducted with the support of ESA/CNES Research & Technologies and DGA (General Delegation for Armament).

STRV RADMON: An integrated high-energy particle detector

NASA Technical Reports Server (NTRS)

Buehler, Martin; Soli, George; Blaes, Brent; Tardio, Gemma

1993-01-01

The RADMON (Radiation Monitor) was developed as a compact device with a 4-kbit SRAM particle detector and two p-FET total dose monitors. Thus it can be used as a spacecraft radiation alarm and in situ total dose monitor. This paper discusses the design and calibration of the SRAM for proton, alpha, and heavy ion detection. Upset rates for the RADMON, based on a newly developed space particle flux algorithm, are shown to vary over eight orders of magnitude. On the STRV (Space Technology Research Vehicle) the RADMON's SRAM will be used to detect trapped protons, solar flares, and cosmic rays and to evaluate our ability to predict space results from ground tests.

Evaluation of a new ballistic vest design for compliance with Standard No. PN-V-87000:2011 using physiological tests.

PubMed

Marszałek, Anna; Grabowska, Grażyna; Łężak, Krzysztof

2018-05-09

Research into newly developed ballistic vests to be worn by police officers under clothing was carried out with air temperature conditions of +20 °C. A ballistic vest should incorporate protective features, comfort and ergonomics. The thermal strain on users who wore the vests was evaluated as an average and individually, after they had been conditioned in high (+50 °C), low (-40 °C) or neutral (+20 °C) air temperatures, while performing various occupational activities. Research involved six police officers aged 36-42 years, who wore civilian clothing used in moderate environmental conditions. During the tests, physiological parameters (internal temperature, local skin temperatures and amount of sweat secreted) were determined. The ease of doing exercises while wearing the vests, vest service and level of discomfort in use were assessed. Research showed that the vests tested, both as an average and individually, meet the requirements of Standard No. PN-V-87000:2011 (clause 4.5).

SU-E-T-563: Multi-Fraction Stereotactic Radiosurgery with Extend System of Gamma Knife: Treatment Verification Using Indigenously Designed Patient Simulating Multipurpose Phantom

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bisht, R; Kale, S; Gopishankar, N

2015-06-15

Purpose: Aim of the study is to evaluate mechanical and radiological accuracy of multi-fraction regimen and validate Gamma knife based fractionation using newly developed patient simulating multipurpose phantom. Methods: A patient simulating phantom was designed to verify fractionated treatments with extend system (ES) of Gamma Knife however it could be used to validate other radiotherapy procedures as well. The phantom has options to insert various density material plugs and mini CT/MR distortion phantoms to analyze the quality of stereotactic imaging. An additional thorax part designed to predict surface doses at various organ sites. The phantom was positioned using vacuum headmore » cushion and patient control unit for imaging and treatment. The repositioning check tool (RCT) was used to predict phantom positioning under ES assembly. The phantom with special inserts for film in axial, coronal and sagittal plane were scanned with X-Ray CT and the acquired images were transferred to treatment planning system (LGP 10.1). The focal precession test was performed with 4mm collimator and an experimental plan of four 16mm collimator shots was prepared for treatment verification of multi-fraction regimen. The prescription dose of 5Gy per fraction was delivered in four fractions. Each fraction was analyzed using EBT3 films scanned with EPSON 10000XL Scanner. Results: The measurement of 38 RCT points showed an overall positional accuracy of 0.28mm. The mean deviation of 0.28% and 0.31 % were calculated as CT and MR image distortion respectively. The radiological focus accuracy test showed its deviation from mechanical center point of 0.22mm. The profile measurement showed close agreement between TPS planned and film measured dose. At tolerance criteria of 1%/1mm gamma index analysis showed a pass rate of > 95%. Conclusion: Our results show that the newly developed multipurpose patient simulating phantom is highly suitable for the verification of fractionated stereotactic radiosurgery using ES of Gamma knife. The study is a part of intramural research project of Research Section, All India Institute of Medical Sciences New Delhi India (A 247)« less

Innovative opto-mechanical design of a laser head for compact thin-disk

NASA Astrophysics Data System (ADS)

Macúchová, Karolina; Smrž, Martin; Řeháková, Martina; Mocek, Tomáš

2016-11-01

We present recent progress in design of innovative versatile laser head for lasers based on thin-disk architecture which are being constructed at the HiLASE centre of the IOP in the Czech Republic. Concept of thin-disk laser technology allows construction of lasers providing excellent beam quality with high average output power and optical efficiency. Our newly designed thin-disk carrier and pump module comes from optical scheme consisting of a parabolic mirror and roof mirrors proposed in 90's. However, mechanical parts and a cooling system were in-house simplified and tailor-made to medium power lasers since no suitable setup was commercially available. Proposed opto-mechanical design is based on stable yet easily adjustable mechanics. The only water nozzle-cooled component is a room-temperature-operated thindisk mounted on a special cooling finger. Cooling of pump optics was replaced by heat conductive transfer from mirrors made of special Al alloy to a massive brass baseplate. Such mirrors are easy to manufacture and very cheap. Presented laser head was manufactured and tested in construction of Er and Yb doped disk lasers. Details of the latest design will be presented.

75 FR 38432 - Railroad Safety Appliance Standards, Miscellaneous Revisions

Federal Register 2010, 2011, 2012, 2013, 2014

2010-07-02

... appliance arrangements on newly constructed railroad cars, locomotives, tenders, or similar vehicles in lieu... advancements and ergonomic design standards for new car construction and ensure that modern rail equipment... designs in the future for railroad cars, locomotives, tenders, or similar vehicles. DATES: (1) Written...

Climate Change: A "Green" Approach to Teaching Contemporary Germany

ERIC Educational Resources Information Center

Melin, Charlotte

2013-01-01

This article describes a newly designed upper division German language course, "Contemporary Germany: Food, Energy Politics," and two sampling methods of assessment for measuring parallel gains in German skills and sustainable development (SD) thinking. Second Language Acquisition (SLA) informed course design, key assignments, and…

EVALUATING THE ECONOMICS AND ENVIRONMENTAL FRIENDLINESS OF NEWLY DESIGNED OR RETROFITTED CHEMICAL PROCESSES

EPA Science Inventory

This work describes a method for using spreadsheet analyses of process designs and retrofits to provide simple and quick economic and environmental evaluations simultaneously. The method focuses attention onto those streams and components that have the largest monetary values and...

Another Look at the Relative Impact of Workplace Design on Training Transfer for Supervisory Communication Skills

ERIC Educational Resources Information Center

Hillsman, Terron L.; Kupritz, Virginia W.

2010-01-01

This ethnographic study extends the findings of earlier research that authenticated the impact of workplace design features on newly acquired communication skills back on the job. The qualitative nature of the earlier study, however, limited quantitative measurement of workplace design features that may have an impact on learned skills. This study…

Visual signature reduction of unmanned aerial vehicles

NASA Astrophysics Data System (ADS)

Zhong, Z. W.; Ma, Z. X.; Jayawijayaningtiyas; Ngoh, J. H. H.

2016-10-01

With the emergence of unmanned aerial vehicles (UAVs) in multiple tactical defence missions, there was a need for an efficient visual signature suppression system for a more efficient stealth operation. One of our studies experimentally investigated the visual signature reduction of UAVs achieved through an active camouflage system. A prototype was constructed with newly developed operating software, Cloak, to provide active camouflage to the UAV model. The reduction of visual signature was analysed. Tests of the devices mounted on UAVs were conducted in another study. A series of experiments involved testing of the concept as well as the prototype. The experiments were conducted both in the laboratory and under normal environmental conditions. Results showed certain degrees of blending with the sky to create a camouflage effect. A mini-UAV made mostly out of transparent plastic was also designed and fabricated. Because of the transparency of the plastic material, the visibility of this UAV in the air is very small, and therefore the UAV is difficult to be detected. After re-designs and tests, eventually a practical system to reduce the visibility of UAVs viewed by human observers from the ground was developed. The system was evaluated during various outdoor tests. The scene target-to-background lightness contrast and the scene target-to-background colour contrast of the adaptive control system prototype were smaller than 10% at a stand-off viewing distance of 20-50 m.

Impact of an electronic health record alert in primary care on increasing hepatitis c screening and curative treatment for baby boomers.

PubMed

Konerman, Monica A; Thomson, Mary; Gray, Kristen; Moore, Meghan; Choxi, Hetal; Seif, Elizabeth; Lok, Anna S F

2017-12-01

Despite effective treatment for chronic hepatitis C, deficiencies in diagnosis and access to care preclude disease elimination. Screening of baby boomers remains low. The aims of this study were to assess the impact of an electronic health record-based prompt on hepatitis C virus (HCV) screening rates in baby boomers in primary care and access to specialty care and treatment among those newly diagnosed. We implemented an electronic health record-based "best practice advisory" (BPA) that prompted primary care providers to perform HCV screening for patients seen in primary care clinic (1) born between 1945 and 1965, (2) who lacked a prior diagnosis of HCV infection, and (3) who lacked prior documented anti-HCV testing. The BPA had associated educational materials, order set, and streamlined access to specialty care for newly diagnosed patients. Pre-BPA and post-BPA screening rates were compared, and care of newly diagnosed patients was analyzed. In the 3 years prior to BPA implementation, 52,660 baby boomers were seen in primary care clinics and 28% were screened. HCV screening increased from 7.6% for patients with a primary care provider visit in the 6 months prior to BPA to 72% over the 1 year post-BPA. Of 53 newly diagnosed patients, all were referred for specialty care, 11 had advanced fibrosis or cirrhosis, 20 started treatment, and 9 achieved sustained virologic response thus far. Implementation of an electronic health record-based prompt increased HCV screening rates among baby boomers in primary care by 5-fold due to efficiency in determining needs for HCV screening and workflow design. Streamlined access to specialty care enabled patients with previously undiagnosed advanced disease to be cured. This intervention can be easily integrated into electronic health record systems to increase HCV diagnosis and linkage to care. (Hepatology 2017;66:1805-1813). © 2017 by the American Association for the Study of Liver Diseases.

Trends in testing behaviours for hepatitis C virus infection and associated determinants: results from population-based laboratory surveillance in Alberta, Canada (1998-2001).

PubMed

Jayaraman, G C; Lee, B; Singh, A E; Preiksaitis, J K

2007-04-01

Little is currently known about hepatitis C virus (HCV) test seeking behaviours at the population level. Given the centralized nature of testing for HCV infection in the province of Alberta, Canada, we had an opportunity to examine HCV testing behaviour at the population level on all newly diagnosed HCV-positive cases using laboratory data to validate the time and number of prior tests for each case. Record linkage identified 3323, 2937, 2660 and 2703 newly diagnosed cases of HCV infections in Alberta during 1998, 1999, 2000 and 2001, respectively, corresponding to age-adjusted rates of 149.8, 129, 114.3 and 113.7 per 100,000 population during these years, respectively. Results from secondary analyses of laboratory data suggest that the majority of HCV cases (95.3%) who were newly diagnosed between 1998 and 2001 were first-time testers for HCV infection. Among repeat testers, analysis of a negative test result within 1 year prior to a first of a positive test report suggests that 211 (38.4%) may be seroconvertors. These findings suggest that 339 or 61.7% of repeat testers may not have discovered their serostatus within 1 year of infection. Among this group, HCV testing was sought infrequently, with a median interval of 2.3 years between the last negative and first positive test. This finding is of concern given the risks for HCV transmission, particularly if risk-taking behaviours are not reduced because of unknown serostatus. These findings also reinforce the need to make the most of each test-seeking event with proper counselling and other appropriate support services.

Endoscopic ultrasound-guided biliary drainage using a newly designed metal stent with a thin delivery system: a preclinical study in phantom and porcine models.

PubMed

Minaga, Kosuke; Kitano, Masayuki; Itonaga, Masahiro; Imai, Hajime; Miyata, Takeshi; Yamao, Kentaro; Tamura, Takashi; Nuta, Junya; Warigaya, Kenji; Kudo, Masatoshi

2017-12-08

This study was designed to evaluate the feasibility and safety of a newly designed self-expandable metal stent for endoscopic ultrasound-guided biliary drainage (EUS-BD) when it was delivered via three different stent delivery systems: a 7.5Fr delivery catheter with a bullet-shaped tip (7.5Fr-bullet), a 7Fr catheter with a bullet-shaped tip (7Fr-bullet), or a 7Fr catheter with a tee-shaped tip (7Fr-tee). This experimental study utilized a porcine model of biliary dilatation involving ten pigs. In the animal study, technical feasibility and clinical outcomes of the stent when placed with each of the delivery systems were examined. In addition, a phantom model was used to measure the resistance of these delivery systems to advancement. Phantom experiments showed that, compared with 7Fr-bullet, 7Fr-tee had less resistance force to the advancement of the stent delivery system. EUS-BD was technically successful in all ten pigs. Fistulous tract dilation was necessary in 100% (2/2), 75% (3/4), and 0% (0/4) of the pigs that underwent EUS-BD using 7.5Fr-bullet, 7Fr-bullet, and 7Fr-tee, respectively. There were no procedure-related complications. Our newly designed metal stent may be feasible and safe for EUS-BD, particularly when delivered by 7Fr-tee, because it eliminates the need for fistulous tract dilation.

Novel antireflux covered metal stent for recurrent occlusion of biliary metal stents: a pilot study.

PubMed

Hamada, Tsuyoshi; Isayama, Hiroyuki; Nakai, Yousuke; Kogure, Hirofumi; Togawa, Osamu; Kawakubo, Kazumichi; Yamamoto, Natsuyo; Ito, Yukiko; Sasaki, Takashi; Tsujino, Takeshi; Sasahira, Naoki; Hirano, Kenji; Tada, Minoru; Koike, Kazuhiko

2014-03-01

Feasibility of antireflux metal stent (ARMS), designed to prevent duodenobiliary reflux, was reported in patients with distal malignant biliary obstruction. In this prospective pilot study, we aimed to evaluate a newly designed ARMS as a reintervention for self-expandable metallic stent (SEMS) occlusion believed to be caused by duodenobiliary reflux. Patients with non-resectable distal malignant biliary obstruction were included in whom a prior SEMS was occluded as a result of sludge or food impaction between March 2010 and January 2012 at two Japanese tertiary referral centers. The occluded SEMS were endoscopically removed, if possible, and subsequently replaced by a newly designed ARMS. We evaluated the technical success rate and complications of ARMS and compared the time to occlusion of ARMS with that of prior SEMS. A total of 13 patients were included. ARMS was successfully placed in all patients in a single procedure. No procedure-related complications were identified. ARMS occlusion occurred in two patients (15%), the causes of which were sludge in one patient and unknown in the other. ARMS migration occurred in four patients (31%). ARMS patency time was significantly longer than that of prior SEMS (median, not available vs 58 days; P = 0.039). This newly designed ARMS is a technically feasible, safe, and effective reintervention for SEMS occlusion as a result of sludge or food impaction. An anti-migration mechanism to improve the outcomes of ARMS should be considered. © 2013 The Authors. Digestive Endoscopy © 2013 Japan Gastroenterological Endoscopy Society.

Lower bound on the time complexity of local adiabatic evolution

NASA Astrophysics Data System (ADS)

Chen, Zhenghao; Koh, Pang Wei; Zhao, Yan

2006-11-01

The adiabatic theorem of quantum physics has been, in recent times, utilized in the design of local search quantum algorithms, and has been proven to be equivalent to standard quantum computation, that is, the use of unitary operators [D. Aharonov in Proceedings of the 45th Annual Symposium on the Foundations of Computer Science, 2004, Rome, Italy (IEEE Computer Society Press, New York, 2004), pp. 42-51]. Hence, the study of the time complexity of adiabatic evolution algorithms gives insight into the computational power of quantum algorithms. In this paper, we present two different approaches of evaluating the time complexity for local adiabatic evolution using time-independent parameters, thus providing effective tests (not requiring the evaluation of the entire time-dependent gap function) for the time complexity of newly developed algorithms. We further illustrate our tests by displaying results from the numerical simulation of some problems, viz. specially modified instances of the Hamming weight problem.

200 MW S-band traveling wave resonant ring development at IHEP

NASA Astrophysics Data System (ADS)

Zhou, Zu-Sheng; Chi, Yun-Long; Git, Meng-Ping; Pei, Guo-Xi

2010-03-01

The resonant-ring is a traveling wave circuit, which is used to produce high peak power with comparatively smaller stored energy. The application to be considered is its use as a high power simulator mainly for testing the klystron ceramic output window, as well as for high power microwave transmission devices. This paper describes the principle of a resonant ring and introduces the structure and property of the newly constructed traveling wave resonant ring at IHEP. Our goal is to produce a 200 MW class resonant ring at 2.856 GHz with a pulse length of 2 μs and repetition rate of 25 Hz. The installation, commissioning and testing of the ring have been completed and a peak power of 200 MW at 3 μs has been achieved. The conditioning results show that all the parameters of the resonant ring reach the design goals.

Tracer Methods for Characterizing Fracture Creation in Engineered Geothermal Systems

DOE Office of Scientific and Technical Information (OSTI.GOV)

Rose, Peter; Harris, Joel

2014-05-08

The aim of this proposal is to develop, through novel high-temperature-tracing approaches, three technologies for characterizing fracture creation within Engineered Geothermal Systems (EGS). The objective of a first task is to identify, develop and demonstrate adsorbing tracers for characterizing interwell reservoir-rock surface areas and fracture spacing. The objective of a second task is to develop and demonstrate a methodology for measuring fracture surface areas adjacent to single wells. The objective of a third task is to design, fabricate and test an instrument that makes use of tracers for measuring fluid flow between newly created fractures and wellbores. In one methodmore » of deployment, it will be used to identify qualitatively which fractures were activated during a hydraulic stimulation experiment. In a second method of deployment, it will serve to measure quantitatively the rate of fluid flowing from one or more activated fracture during a production test following a hydraulic stimulation.« less

A new veno-venous bypass type for ex-vivo liver resection in dogs.

PubMed

Lei, Peng; Liu, Shi-Qi; Cui, Xiao-Hai; Lv, Yi; Zhao, Ge; Li, Jian-Hui

2013-08-01

Ex-vivo liver resection is a procedure in which the liver is completely removed, perfused and after bench surgery, the liver is autotransplanted to the original site. Ex-vivo liver resection is an important treatment for unresectable liver tumors. This surgical procedure requires long operation time, during which blood flow must be carefully maintained to avoid venous congestion. An effective veno-venous bypass (VVB) may meet this requirement. The present study was to test our new designed VVB device which comprised one heparinized polyvinylchloride tube and three magnetic rings. The efficacy of this device was tested in five dogs. A VVB was established in 6-10 minutes. There was no leakage during the procedure. Hemodynamics was stable at anhepatic phase, which indicated that the bypass was successful. This newly-developed VVB device maintained circulation stability during ex-vivo liver resection in our dog model and thus, this VVB device significantly shortened the operation time.

Tuberculosis-diabetes epidemiology in the border and non-border regions of Tamaulipas, Mexico.

PubMed

Abdelbary, Bassent E; Garcia-Viveros, Moncerrato; Ramirez-Oropesa, Horacio; Rahbar, Mohammad H; Restrepo, Blanca I

2016-12-01

Type 2 diabetes mellitus (DM) is a re-emerging risk factor for TB development and adverse TB outcomes. As a follow-up of our previous study in 1998-2004, we reassessed prevalence of DM and its associated factors among 8431 TB patients using surveillance data from 2006 to 2013 for the Mexican state of Tamaulipas, across the border with Texas. Prevalence of DM was 25.2%, with an increase of at least 2.8% over the study period. Newly discovered factors associated with TB-DM (versus no DM) were lower education and higher unemployment (p < 0.001), which are reportedly associated with poorer DM management. At least 15% of the DM patients were newly-diagnosed and younger than those previously diagnosed, showing the importance of early DM diagnosis at TB clinics. TB-DM patients were more likely to have smear-positive, pulmonary (versus extra-pulmonary) and drug-resistant TB (1.9-, 3.8- and 1.4-fold, respectively). During treatment, TB-DM patients were more likely to be smear-positive, and less likely to die or abandon TB treatment. Thus, the increasing prevalence of DM among TB, and its association with low education, features of a more contagious TB, and drug resistance, highlight the need for design of TB management programs in DM patients, blood testing of all new TB patients for DM, and if positive for DM, testing for drug resistance. Copyright © 2016 Elsevier Ltd. All rights reserved.

Physician Enabling Skills Questionnaire

PubMed Central

Hudon, Catherine; Lambert, Mireille; Almirall, José

2015-01-01

Abstract Objective To evaluate the reliability and validity of the newly developed Physician Enabling Skills Questionnaire (PESQ) by assessing its internal consistency, test-retest reliability, concurrent validity with patient-centred care, and predictive validity with patient activation and patient enablement. Design Validation study. Setting Saguenay, Que. Participants One hundred patients with at least 1 chronic disease who presented in a waiting room of a regional health centre family medicine unit. Main outcome measures Family physicians’ enabling skills, measured with the PESQ at 2 points in time (ie, while in the waiting room at the family medicine unit and 2 weeks later through a mail survey); patient-centred care, assessed with the Patient Perception of Patient-Centredness instrument; patient activation, assessed with the Patient Activation Measure; and patient enablement, assessed with the Patient Enablement Instrument. Results The internal consistency of the 6 subscales of the PESQ was adequate (Cronbach α = .69 to .92). The test-retest reliability was very good (r = 0.90; 95% CI 0.84 to 0.93). Concurrent validity with the Patient Perception of Patient-Centredness instrument was good (r = −0.67; 95% CI −0.78 to −0.53; P < .001). The PESQ accounts for 11% of the total variance with the Patient Activation Measure (r2 = 0.11; P = .002) and 19% of the variance with the Patient Enablement Instrument (r2 = 0.19; P < .001). Conclusion The newly developed PESQ presents good psychometric properties, allowing for its use in practice and research. PMID:26889507

Newly invented biobased materials from low-carbon, diverted waste fibers: research methods, testing, and full-scale application in a case study structure

Treesearch

Julee A Herdt; John Hunt; Kellen Schauermann

2016-01-01

This project demonstrates newly invented, biobased construction materials developed by applying lowcarbon, biomass waste sources through the Authors’ engineered fiber processes and technology. If manufactured and applied large-scale the project inventions can divert large volumes of cellulose waste into high-performance, low embodied energy, environmental construction...

The Effect of Structural Modifications on Ionic Conductivity in Newly-Designed Polyester Electrolytes

NASA Astrophysics Data System (ADS)

Pesko, Danielle; Jung, Yuki; Coates, Geoff; Balsara, Nitash

2015-03-01

Gaining a fundamental understanding of the relationship between molecular structure and ionic conductivity of polymer electrolytes is an essential step toward designing next generation materials for battery applications. In this study, we use a systematic set of newly-designed polyesters with varying side-chain lengths and oxygen functional groups to elucidate the effects of structural modifications on the conductive properties of the corresponding electrolytes. Mixtures of polyesters and lithium bis(trifluromethanesulfonyl)imide (LiTFSI) were characterized using ac impedance spectroscopy to measure the ionic conductivity at various temperatures and salt concentrations. The relative conductivities of these electrolytes in the dilute limit are directly comparable to results of molecular dynamics simulations performed using the same polymers. The simulations correspond well with the experimental results, and provide molecular level insight about the solvation environment of the lithium ions and how the ions transport through these polyesters.

Blood lead level analysis among refugee children resettled in New Hampshire and Rhode Island.

PubMed

Raymond, Jaime S; Kennedy, Chinaro; Brown, Mary Jean

2013-01-01

To examine the association between refugee status and elevated blood lead levels (EBLLs) among children living in two U.S. cities and to assess the effect of the Centers for Disease Control and Prevention recommendations for BLL testing of newly emigrated refugee children for EBLLs. A longitudinal study was conducted of 1,007 refugee children and 953 nonrefugee children living, when blood testing occurred, in the same buildings in Manchester, New Hampshire and Providence, Rhode Island. Surveillance and blood lead data were collected from both sites, including demographic information, BLLs, sample type, refugee status, and age of housing. Refugee children living in Manchester were statistically significantly more likely to have an EBLL compared with nonrefugee children even after controlling for potential confounders. We did not find this association in Providence. Compared with before enactment, the mean time of refugee children to fall below 10 μg/dL was significantly shorter after the recommendations to test newly emigrated children were enacted. Refugee children living in Manchester were significantly more likely to have an EBLL compared with nonrefugee children. And among refugee children, we found a statistically significant difference in the mean days to BLL decline <10 μg/dL before and after recommendations to test newly emigrated children. © 2012 Wiley Periodicals, Inc.

Evaluation of a newly designed sandwich enzyme linked immunosorbent assay for the detection of hydatid antigen in serum, urine and cyst fluid for diagnosis of cystic echinococcosis.

PubMed

Chaya, Dr; Parija, Subhash Chandra

2013-07-01

Cystic echinococcosis (CE) is a zoonotic disease of humans with variable clinical manifestations. Imaging and immunological methods are currently the mainstay of diagnosis of this disease. Although the immunological tests for detection of anti-echinococcal antibodies have several disadvantages, they are widely being used. Antigen is far more superior than antibody detection test as they can provide a specific parasitic diagnosis. A sandwich enzyme linked immunosorbent assay (ELISA) was designed using antibodies to 24 kDa urinary hydatid antigen for the detection of hydatid antigens in urine, serum and cyst fluid specimens. The performance of this novel test was compared with that of other hydatid antibody detection ELISA and enzyme immune transfer blot (EITB) using radiological and surgical confirmation as the gold standard. The antigen detection ELISA showed 100% sensitivity and specificity when tested with cyst fluid. On testing urine and serum, the antigen detection ELISA was found to be more specific than antibody detection ELISA. EITB was found to be the most sensitive and specific test. ELISA using polyclonal antibodies against 24 kDa urinary hydatid protein was moderately sensitive to detect hydatid antigen in serum and urine. Hence polyclonal antibodies to 24 kDa urinary hydatid antigen can be used as an alternative source of antibody to detect hydatid antigen in serum, urine and cyst fluid. In the present study, EITB was found to be highly specific test for detection of hydatid antibodiesin serum. 24 kDa protein was found to be specific and of diagnostic value in CE.

Effects of a blended learning module on self-reported learning performances in baccalaureate nursing students.

PubMed

Hsu, Li-Ling; Hsieh, Suh-Ing

2011-11-01

This article is a report of a quasi-experimental study of the effects of blended modules on nursing students' learning of ethics course content. There is yet to be an empirically supported mix of strategies on which a working blended learning model can be built for nursing education. This was a two-group pretest and post-test quasi-experimental study in 2008 involving a total of 233 students. Two of the five clusters were designated the experimental group to experience a blended learning model, and the rest were designated the control group to be given classroom lectures only. The Case Analysis Attitude Scale, Case Analysis Self-Evaluation Scale, Blended Learning Satisfaction Scale, and Metacognition Scale were used in pretests and post-tests for the students to rate their own performance. In this study, the experimental group did not register significantly higher mean scores on the Case Analysis Attitude Scale at post-test and higher mean ranks on the Case Analysis Self-Evaluation Scale, the Blended Learning Satisfaction Scale, and the Metacognition Scale at post-test than the control group. Moreover, the experimental group registered significant progress in the mean ranks on the Case Analysis Self-Evaluation Scale and the Metacognition Scale from pretest to post-test. No between-subjects effects of four scales at post-test were found. Newly developed course modules, be it blended learning or a combination of traditional and innovative components, should be tested repeatedly for effectiveness and popularity for the purpose of facilitating the ultimate creation of a most effective course module for nursing education. © 2011 Blackwell Publishing Ltd.

Self Diagnostic Accelerometer Testing on the C-17 Aircraft

NASA Technical Reports Server (NTRS)

Tokars, Roger P.; Lekki, John D.

2013-01-01

The self diagnostic accelerometer (SDA) developed by the NASA Glenn Research Center was tested for the first time in an aircraft engine environment as part of the Vehicle Integrated Propulsion Research (VIPR) program. The VIPR program includes testing multiple critical flight sensor technologies. One such sensor, the accelerometer, measures vibrations to detect faults in the engine. In order to rely upon the accelerometer, the health of the accelerometer must be ensured. The SDA is a sensor system designed to actively determine the accelerometer structural health and attachment condition, in addition to vibration measurements. The SDA uses a signal conditioning unit that sends an electrical chirp to the accelerometer and recognizes changes in the response due to changes in the accelerometer health and attachment condition. To demonstrate the SDAs flight worthiness and robustness, multiple SDAs were mounted and tested on a C-17 aircraft engine. The engine test conditions varied from engine off, to idle, to maximum power. The SDA attachment conditions were varied from fully tight to loose. The newly developed SDA health algorithm described herein uses cross correlation pattern recognition to discriminate a healthy from a faulty SDA. The VIPR test results demonstrate for the first.

Moisturizers are effective in the treatment of xerosis irrespectively from their particular formulation: results from a prospective, randomized, double-blind controlled trial.

PubMed

Shim, J H; Park, J H; Lee, J H; Lee, D Y; Lee, J H; Yang, J M

2016-02-01

Many companies claim that their moisturizers are superior to others based on their ingredients. To compare the efficacy and safety of the most popular moisturizers in the field. A randomized, double-blind, controlled study was performed on 80 patients with moderate to severe xerosis. The test agents included the newly developed cream containing topical recombinant human epidermal growth factor (EGF), its vehicle without EGF and four additional therapeutic moisturizers. The study subjects applied the test agents on designated skin areas twice daily for 4 weeks. All of the clinical assessments and non-invasive objective measurements were performed at baseline, and on days 14 and 28 of the study. All of the test agents significantly improved the clinical symptoms of xerosis. The biophysical parameters similarly improved from baseline (P < 0.05). None of the test agents performed significantly better than did another. In the treatment of xerosis, consistent and regular moisturizer use is much more important than the moisturizer's particular formulation. © 2015 European Academy of Dermatology and Venereology.

Teaching Insect Retinal Physiology with Newly Designed, Inexpensive Micromanipulators

ERIC Educational Resources Information Center

Krans, Jacob; Gilbert, Cole; Hoy, Ron

2006-01-01

In this article, we detail how to produce two inexpensive micromanipulators that offer high precision (approximately 25 micrometers) along a single axis of movement. The more expensive of the designs provides improved versatility along multiple axes. Both manipulators offer substantial savings over commercially available micromanipulators with…

Sampling design for early detection of aquatic invasive species in Great Lakes ports

EPA Science Inventory

We evaluated a pilot adaptive monitoring program for aquatic invasive species (AIS) early detection in Lake Superior. The monitoring program is designed to detect newly-introduced fishes, and encompasses the lake’s three major ports (Duluth-Superior, Sault Ste. Marie, Thund...

Sampling design for aquatic invasive species early detection in Great Lakes ports

EPA Science Inventory

From 2006-2012, we evaluated a pilot aquatic invasive species (AIS) early detection monitoring program in Lake Superior that was designed to detect newly introduced fishes. We established survey protocols for three major ports (Duluth-Superior, Sault Ste. Marie, Thunder Bay) and ...

GREENER CHEMICAL PROCESS DESIGN ALTERNATIVES ARE REVEALED USING THE WASTE REDUCTION DECISION SUPPORT SYSTEM (WAR DSS)

EPA Science Inventory

The Waste Reduction Decision Support System (WAR DSS) is a Java-based software product providing comprehensive modeling of potential adverse environmental impacts (PEI) predicted to result from newly designed or redesigned chemical manufacturing processes. The purpose of this so...

Development and initial testing of functional task exercise on older adults with cognitive impairment at risk of Alzheimer's disease--FcTSim programme--a feasibility study.

PubMed

Law, Lawla L F; Barnett, Fiona; Yau, Matthew K; Gray, Marion A

2013-12-01

The purpose of this study was to illustrate the development of a new functional task-based exercise programme and initially test its feasibility as well as effectiveness for older adults with mild cognitive impairment (MCI). This study used a single-group repeated-measures design. A total of 11 patients (mean age 71.8 years) were recruited to participate in a structured functional task exercise programme for 10 weeks. All outcome measures were undertaken at baseline, post-intervention and post-3-month follow-up using the Neurobehavioral Cognitive Status Examination (NCSE), Verbal Fluency Test (VFT), Chinese Version Verbal Learning Test (CVVLT), Lawton Instrumental Activities of Daily Living Scale (Lawton IADL) and Problems in Everyday Living test (PEDL). Data were analysed using a repeated-measures analysis of variance. Cohen's d effect size was used to assess the practical significant effects. The participants showed significant improvement in NCSE composite score, VFT, CVVLT total free recall, CVVLT 10-minute delayed free recall, Lawton IADL and PEDL. Results of this study demonstrate that the newly designed functional task exercise programme, which uses simulated tasks, is feasible and beneficial to cognitive functions and functional status of older persons with MCI. The findings of the current study further reinforce occupational therapy practitioners' understanding that "occupation" is a "means" and an "end". Further study with a larger population is needed to draw more definitive conclusions. Copyright © 2013 John Wiley & Sons, Ltd.

Advanced Disease at Enrollment in HIV Care in Four Sub-Saharan African Countries: Change from 2006-2011 and Multi-Level Predictors in 2011

PubMed Central

Hoffman, Susie; Wu, Yingfeng; Lahuerta, Maria; Kulkarni, Sarah Gorrell; Nuwagaba-Biribonwoha, Harriet; Sadr, Wafaa El; Remien, Robert H.; Mugisha, Veronicah; Hawken, Mark; Chuva, Ema; Nash, Denis; Elul, Batya

2015-01-01

Objectives To examine changes between 2006 and 2011 in the proportion of HIV-positive patients newly-enrolled in HIV care with advanced disease and the median CD4+ cell count at enrollment; and identify patient-, facility-, and contextual-level factors associated with late enrollment in care in 2011. Design Cross sectional over time. Methods For time trends analyses, routinely-collected patient-level data (307,110 adults newly-enrolled in 138 HIV clinical care facilities) in Kenya, Mozambique, Rwanda and Tanzania; and for analyses of correlates, patient-level data (46,201 in 195 facilities), and facility- and population-level survey data were used. Late enrollment was defined as CD4+ count ≤350 cells/μl and/or WHO clinical stage 3/4. Results Late enrollment declined from 69.9% to 57.2%, (p<0.0001); median CD4+ count increased from 242 to 292 cells/μL (ptrend<0.0001). In 2011, risk of late enrollment was significantly higher for men and non-pregnant women vs. pregnant women; patients aged >25 vs. 15-25 years; non-married vs. married; and those entering from sites other than prevention of mother to child transmission (PMTCT). More extensive HIV testing coverage in the region of a facility was significantly associated with lower risk of late enrollment. Conclusions Despite improvement, in 2011, 57% of patients entered HIV care already ART-eligible. The lower risk of late enrollment among those referred from PMTCT and in regions where HIV testing coverage was higher suggests that innovative approaches to rapidly increase testing uptake among people living with HIV prior to the development of symptoms have the potential to reduce late enrollment in care. PMID:25136842

Health Promotion Outcomes of a Newly Developed Elastic Band Exercise Program for Older Adults in the Community: A Pilot Test.

PubMed

Chan, Shu-Ya; Kuo, Chang-Chih; Chen, Kuei-Min; Tseng, Wei-Shyuan; Huang, Hsin-Ting; Li, Chun-Huw

2016-06-01

Studies indicate that the incidence of disease, the mortality rate, and medical costs are significantly higher in people aged 65 years and over who do not engage in physical activities than in their peers who do engage in these activities. Therefore, promoting appropriate physical activity among older adults in the community is essential to delaying the health implications of aging. This pilot test was developed to assess the effectiveness of a newly developed Senior Elastic Band (SEB) exercise program on the health of older adults in community care stations. A quasiexperimental design was used. A convenience sample of 20 participants from a community care station was recruited. The SEB intervention included three phases (warm-up, aerobic motion, and static stretching) and was conducted three times per week, 40 minutes per session for 1 month. Twelve health indicators in three categories (functional fitness, self-perceived health status, and sleep quality) were examined before and immediately after 1 month of SEB exercises. Participants showed improved performance at the end of the 1-month study for the following indicators: lung capacity, cardiopulmonary fitness, upper and lower body flexibilities, upper limb muscle power, lower limb muscle endurance, and self-perceived physical health status (all ps < .05). No significant differences were identified for the other indicators. The SEB exercise program shows preliminary and promising effects on improving the health of older adults in a community care station. Healthcare professionals who work with older adults living in the community may consider the SEB exercise program as a health promotion modality to recommend and implement with this population. However, we recommend further testing the long-term effects of this program on a larger population.

Diagnostic accuracy of a point-of-care urine test for tuberculosis screening among newly-diagnosed HIV-infected adults: a prospective, clinic-based study.

PubMed

Drain, Paul K; Losina, Elena; Coleman, Sharon M; Giddy, Janet; Ross, Douglas; Katz, Jeffrey N; Walensky, Rochelle P; Freedberg, Kenneth A; Bassett, Ingrid V

2014-02-26

A rapid diagnostic test for active tuberculosis (TB) at the clinical point-of-care could expedite case detection and accelerate TB treatment initiation. We assessed the diagnostic accuracy of a rapid urine lipoarabinomannan (LAM) test for TB screening among HIV-infected adults in a TB-endemic setting. We prospectively enrolled newly-diagnosed HIV-infected adults (≥18 years) at 4 outpatient clinics in Durban from Oct 2011-May 2012, excluding those on TB therapy. A physician evaluated all participants and offered CD4 cell count testing. Trained study nurses collected a sputum sample for acid-fast bacilli smear microscopy (AFB) and mycobacterial culture, and performed urine LAM testing using Determine™ TB LAM in the clinic. The presence of a band regardless of intensity on the urine LAM test was considered positive. We defined as the gold standard for active pulmonary TB a positive sputum culture for Mycobacterium tuberculosis. Diagnostic accuracy of urine LAM was assessed, alone and in combination with smear microscopy, and stratified by CD4 cell count. Among 342 newly-diagnosed HIV-infected participants, 190 (56%) were male, mean age was 35.6 years, and median CD4 was 182/mm3. Sixty participants had culture-positive pulmonary TB, resulting in an estimated prevalence of 17.5% (95% CI 13.7-22.0%). Forty-five (13.2%) participants were urine LAM positive. Mean time from urine specimen collection to LAM test result was 40 minutes (95% CI 34-46 minutes). Urine LAM test sensitivity was 28.3% (95% CI 17.5-41.4) overall, and 37.5% (95% CI 21.1-56.3) for those with CD4 count <100/mm3, while specificity was 90.1% (95% CI 86.0-93.3) overall, and 86.9% (95% CI 75.8-94.2) for those with CD4 < 100/mm3. When combined with sputum AFB (either test positive), sensitivity increased to 38.3% (95% CI 26.0-51.8), but specificity decreased to 85.8% (95% CI 81.1-89.7). In this prospective, clinic-based study with trained nurses, a rapid urine LAM test had low sensitivity for TB screening among newly-diagnosed HIV-infected adults, but improved sensitivity when combined with sputum smear microscopy.

Does pharmacist-supervised intervention through pharmaceutical care program influence direct healthcare cost burden of newly diagnosed diabetics in a tertiary care teaching hospital in Nepal: a non-clinical randomised controlled trial approach.

PubMed

Upadhyay, Dinesh Kumar; Ibrahim, Mohamed Izham Mohamed; Mishra, Pranaya; Alurkar, Vijay M; Ansari, Mukhtar

2016-02-29

Cost is a vital component for people with chronic diseases as treatment is expected to be long or even lifelong in some diseases. Pharmacist contributions in decreasing the healthcare cost burden of chronic patients are not well described due to lack of sufficient evidences worldwide. In developing countries like Nepal, the estimation of direct healthcare cost burden among newly diagnosed diabetics is still a challenge for healthcare professionals, and pharmacist role in patient care is still theoretical and practically non-existent. This study reports the impact of pharmacist-supervised intervention through pharmaceutical care program on direct healthcare costs burden of newly diagnosed diabetics in Nepal through a non-clinical randomised controlled trial approach. An interventional, pre-post non-clinical randomised controlled study was conducted among randomly distributed 162 [control (n = 54), test 1 (n = 54) and test 2 (n = 54) groups] newly diagnosed diabetics by a consecutive sampling method for 18 months. Direct healthcare costs (direct medical and non-medical costs) from patients perspective was estimated by 'bottom up' approach to identify their out-of-pocket expenses (1USD = NPR 73.38) before and after intervention at the baseline, 3, 6, 9 and 12 months follow-ups. Test groups' patients were nourished with pharmaceutical care intervention while control group patients only received care from physician/nurses. Non-parametric tests i.e. Friedman test, Mann-Whitney U test and Wilcoxon signed rank test were used to find the differences in direct healthcare costs among the groups before and after the intervention (p ≤ 0.05). Friedman test identified significant differences in direct healthcare cost of test 1 (p < 0.001) and test 2 (p < 0.001) groups patients. However, Mann-Whitney U test justified significant differences in direct healthcare cost between control group and test 1 group, and test 2 group patients at 6-months (p = 0.009, p = 0.010 respectively), 9-months (p = 0.005, p = 0.001 respectively) and 12-months (p < 0.001, p < 0.001 respectively). Pharmacist supervised intervention through pharmaceutical care program significantly decreased direct healthcare costs of diabetics in test groups compared to control group and hence describes pharmacist's contribution in minimizing direct healthcare cost burden of patients.

Autism spectrum disorders: information for pediatricians supporting families of young children on the spectrum.

PubMed

Patterson, Stephanie; Smith, Veronica; Jelen, Michaela

2012-01-01

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder affecting in US 1 in 110 individuals.(1) As increasingly younger children are receiving ASD diagnoses, many pediatricians are now faced with the unique needs of parents and other caregivers of newly diagnosed toddlers and young children. This chapter provides an overview of ASD designed to offer information and resources to pediatricians that could, in turn, be provided to families of children newly diagnosed with ASD.

Advanced Stirling Convertor Dual Convertor Controller Testing at NASA Glenn Research Center in the Radioisotope Power Systems System Integration Laboratory

NASA Technical Reports Server (NTRS)

Dugala, Gina M.; Taylor, Linda M.; Bell, Mark E.; Dolce, James L.; Fraeman, Martin; Frankford, David P.

2015-01-01

NASA Glenn Research Center (GRC) developed a non-nuclear representation of a Radioisotope Power System (RPS) consisting of a pair of Advanced Stirling Convertors (ASC), a Dual Convertor Controller (DCC) EM (engineering model) 2 & 3, and associated support equipment, which were tested in the Radioisotope Power Systems System Integration Laboratory (RSIL). The DCC was designed by the Johns Hopkins University/Applied Physics Laboratory (JHU/APL) to actively control a pair of Advanced Stirling Convertors (ASC). The first phase of testing included a Dual Advanced Stirling Convertor Simulator (DASCS) which was developed by JHU/APL and simulates the operation and electrical behavior of a pair of ASC's in real time via a combination of hardware and software. RSIL provides insight into the electrical interactions between a representative radioisotope power generator, its associated control schemes, and realistic electric system loads. The first phase of integration testing included the following spacecraft bus configurations: capacitive, battery, and supercapacitor. A load profile, created based on data from several missions, tested the RPS and RSIL ability to maintain operation during load demands above and below the power provided by the RPS. The integration testing also confirmed the DCC's ability to disconnect from the spacecraft when the bus voltage dipped below 22 V or exceeded 36 V. Once operation was verified with the DASCS, the tests were repeated with actual operating ASC's. The goal of this integration testing was to verify operation of the DCC when connected to a spacecraft and to verify the functionality of the newly designed RSIL. The results of these tests are presented in this paper.

Travlink Operational Test Evaluation Report; Final Report

DOT National Transportation Integrated Search

1996-08-01

">THE OBJECTIVES OF THE TRAVLINK OPERATIONAL TEST WERE TO IMPROVE TRANSIT FLEET MANAGEMENT, IMPROVE THE TIMELINESS AND ACCURACY OF TRAVEL INFORMATION, AND ENCOURAGE TRANSIT RIDERSHIP. THE PROJECT'S CORRIDOR WAS A NEWLY RECONSTRUCTED FREEWAY THAT WAS ...

Exploring selection and recruitment processes for newly qualified nurses: a sequential-explanatory mixed-method study.

PubMed

Newton, Paul; Chandler, Val; Morris-Thomson, Trish; Sayer, Jane; Burke, Linda

2015-01-01

To map current selection and recruitment processes for newly qualified nurses and to explore the advantages and limitations of current selection and recruitment processes. The need to improve current selection and recruitment practices for newly qualified nurses is highlighted in health policy internationally. A cross-sectional, sequential-explanatory mixed-method design with 4 components: (1) Literature review of selection and recruitment of newly qualified nurses; and (2) Literature review of a public sector professions' selection and recruitment processes; (3) Survey mapping existing selection and recruitment processes for newly qualified nurses; and (4) Qualitative study about recruiters' selection and recruitment processes. Literature searches on the selection and recruitment of newly qualified candidates in teaching and nursing (2005-2013) were conducted. Cross-sectional, mixed-method data were collected from thirty-one (n = 31) individuals in health providers in London who had responsibility for the selection and recruitment of newly qualified nurses using a survey instrument. Of these providers who took part, six (n = 6) purposively selected to be interviewed qualitatively. Issues of supply and demand in the workforce, rather than selection and recruitment tools, predominated in the literature reviews. Examples of tools to measure values, attitudes and skills were found in the nursing literature. The mapping exercise found that providers used many selection and recruitment tools, some providers combined tools to streamline process and assure quality of candidates. Most providers had processes which addressed the issue of quality in the selection and recruitment of newly qualified nurses. The 'assessment centre model', which providers were adopting, allowed for multiple levels of assessment and streamlined recruitment. There is a need to validate the efficacy of the selection tools. © 2014 John Wiley & Sons Ltd.

Newly graduated nurses' occupational commitment and its associations with professional competence and work-related factors.

PubMed

Numminen, Olivia; Leino-Kilpi, Helena; Isoaho, Hannu; Meretoja, Riitta

2016-01-01

To explore newly graduated nurses' occupational commitment and its associations with their self-assessed professional competence and other work-related factors. As a factor affecting nurse turnover, newly graduated nurses' occupational commitment and its associations with work-related factors needs exploring to retain adequate workforce. Nurses' commitment has mainly been studied as organisational commitment, but newly graduated nurses' occupational commitment and its association with work-related factors needs further studying. This study used descriptive, cross-sectional, correlation design. A convenience sample of 318 newly graduated nurses in Finland participated responding to an electronic questionnaire. Statistical software, NCSS version 9, was used in data analysis. Frequencies, percentages, ranges, means and standard deviations summarised the data. Multivariate Analyses of Variance estimated associations between occupational commitment and work-related variables. IBM SPSS Amos version 22 estimated the model fit of Occupational Commitment Scale and Nurse Competence Scale. Newly graduated nurses' occupational commitment was good, affective commitment reaching the highest mean score. There was a significant difference between the nurse groups in favour of nurses at higher competence levels in all subscales except in limited alternatives occupational commitment. Multivariate analyses revealed significant associations between subscales of commitment and competence, turnover intentions, job satisfaction, earlier professional education and work sector, competence counting only through affective dimension. The association between occupational commitment and low turnover intentions and satisfaction with nursing occupation was strong. Higher general competence indicated higher overall occupational commitment. Managers' recognition of the influence of all dimensions of occupational commitment in newly graduated nurses' professional development is important. Follow-up studies of newly graduated nurses' commitment, its relationship with quality care, managers' role in enhancing commitment and evaluation of the impact of interventions on improving commitment need further studying. © 2015 John Wiley & Sons Ltd.

Increased adolescent HIV testing with a hybrid mobile strategy in Uganda and Kenya.

PubMed

Kadede, Kevin; Ruel, Theodore; Kabami, Jane; Ssemmondo, Emmanuel; Sang, Norton; Kwarisiima, Dalsone; Bukusi, Elizabeth; Cohen, Craig R; Liegler, Teri; Clark, Tamara D; Charlebois, Edwin D; Petersen, Maya L; Kamya, Moses R; Havlir, Diane V; Chamie, Gabriel

2016-09-10

We sought to increase adolescent HIV testing across rural communities in east Africa and identify predictors of undiagnosed HIV. Hybrid mobile testing. We enumerated 116 326 adolescents (10-24 years) in 32 communities of Uganda and Kenya ( NCT01864603): 98 694 (85%) reported stable (≥6 months of prior year) residence. In each community we performed hybrid testing: 2-week multidisease community health campaign that included HIV testing, followed by home-based testing of community health campaign nonparticipants. We measured adolescent HIV testing coverage and prevalence, and determined predictors of newly diagnosed HIV among HIV-infected adolescents using multivariable logistic regression. A total of 86 421 (88%) stable adolescents tested for HIV; coverage was 86, 90, and 88% in early (10-14), mid (15-17), and late (18-24) adolescents, respectively. Self-reported prior testing was 9, 26, and 55% in early, mid, and late adolescents tested, respectively. HIV prevalence among adolescents tested was 1.6 and 0.6% in Ugandan women and men, and 7.1 and 1.5% in Kenyan women and men, respectively. Prevalence increased in mid-adolescence for women and late adolescence for men. Among HIV-infected adolescents, 58% reported newly diagnosed HIV. In multivariate analysis of HIV-infected adolescents, predictors of newly diagnosed HIV included male sex [odds ratio (OR) = 1.97 (95% confidence interval (CI): 1.42-2.73)], Ugandan residence [OR = 2.63 (95% CI: 2.08-3.31)], and single status [OR = 1.62 (95% CI: 1.23-2.14) vs. married)]. The SEARCH hybrid strategy tested 88% of stable adolescents for HIV, a substantial increase over the 28% reporting prior testing. The majority (57%) of HIV-infected adolescents were new diagnoses. Mobile HIV testing for adults should be leveraged to reach adolescents for HIV treatment and prevention.

TIRGO and its instrumentation

NASA Astrophysics Data System (ADS)

Baffa, Carlo; Gennari, Sandro; Hunt, Leslie K.; Lisi, Franco; Tofani, Gianni; Vanzi, Leonardo

1995-09-01

We describe the general characteristics of the TIRGO infrared telescope, located on Gornergrat (Switzerland), and its most recent instrumentation. This telescope is specifically designed for infrared astronomical observations. Two newly designed instruments are presented: the imaging camera Arnica and the long-slit spectrometer LonGSp, both based on two-dimensional array detectors.

Low Income Women and Physician Breastfeeding Advice: A Regional Assessment

ERIC Educational Resources Information Center

Stolzer, J; Zeece, Pauline

2006-01-01

Objectives: The aims of the pilot study presented here were to determine whether low income women were receiving compendious breastfeeding advice from their attending physicians. Design: This study assessed low income women's reports of physician breastfeeding advice using a newly designed Likert scaled survey based on the American Surgeon…

Wedging Creationism into the Academy

ERIC Educational Resources Information Center

Forrest, Barbara; Branch, Glenn

2005-01-01

In 1999, William Dembski became director of the newly established Michael Polanyi Center at Baylor University, thanks to the support of Baylor's president Robert Sloan. The center was, as Dembski observed, "the first intelligent design think tank at a research university." As such, it fulfilled a crucial objective of the "intelligent design"…

The Room Itself is Active: How Classroom Design Impacts Student Engagement

ERIC Educational Resources Information Center

Rands, Melissa L.; Gansemer-Topf, Ann M.

2017-01-01

A responsive case study evaluation approach utilizing interviews and focus groups collected student and faculty perspectives on examined how instructors and students utilized a newly redesigned active learning space at Iowa State University and the relationship of this design with environmental and behavioral factors of student engagement. The…

Course of Cytomegalovirus Retinitis in the Era of Highly Active Antiretroviral Therapy: Five-year Outcomes

PubMed Central

Jabs, Douglas A.; Ahuja, Alka; Van Natta, Mark; Lyon, Alice; Srivastava, Sunil; Gangaputra, Sapna

2010-01-01

Purpose To describe the five-year outcomes of patients with cytomegalovirus (CMV) retinitis and AIDS in the era of highly active antiretroviral therapy (HAART). Design Prospective, multicenter, observational study Participants 503 patients with AIDS and CMV retinitis Methods Follow-up every 3 months with medical history, ophthalmologic examination, laboratory testing, and retinal photographs. Participants were classified as having previously-diagnosed CMV retinitis and immune recovery (CD4+ T cells >100 cells/µL), previously-diagnosed retinitis and immune compromise, and newly-diagnosed CMV retinitis (diagnosis < 45 days prior to enrollment). Main outcome measures Mortality, retinitis progression (movement of the border of a CMV lesion ≥ ½ disc diameter or occurrence of a new lesion), retinal detachment, immune recovery uveitis (IRU), and visual loss (to worse than 20/40 and to 20/200 or worse), Results Overall mortality was 9.8 deaths/100 person-years (PY). Rates varied by group at enrollment from 3.0/100 PY for those with previously-diagnosed retinitis and immune recovery to 26.1/100 PY for those with newly-diagnosed retinitis. The rate of retinitis progression was 7.0/100 PY and varied from 1.4/100 PY for those with previously-diagnosed retinitis and immune recovery to 28.0/100 PY for those with newly-diagnosed retinitis. The rate of retinal detachment was 2.3/100 eye-years (EY) and varied from 1.2/100 EY for those with previously-diagnosed retinitis and immune recovery to 4.9/100 EY for those with newly-diagnosed retinitis. The rate of IRU was 1.7/100 PY and varied from 1.3/100 PY for those with previously-diagnosed retinitis and immune recovery at enrollment to 3.6/100 PY for those with newly-diagnosed retinitis who subsequently experienced immune recovery. The rates of visual loss to worse than 20/40 and to 20/200 or worse were 7.9/100 EY and 3.4/100 EY, respectively; they varied from 6.1/100 EY and 2.7/100 EY for those with previously-diagnosed retinitis and immune recovery to 11.8/100 EY and 5.1/100 EY for those with newly-diagnosed retinitis. Although the event rates tended to decline with time, in general, at no time did they reach zero. Conclusions Despite the availability of HAART, patients with AIDS and CMV retinitis remain at increased risk for mortality, retinitis progression, complications of the retinitis, and visual loss over a 5-year period. PMID:20673591

The physical environment and patients' activities and care: A comparative case study at three newly built stroke units.

PubMed

Anåker, Anna; von Koch, Lena; Sjöstrand, Christina; Heylighen, Ann; Elf, Marie

2018-04-20

To explore and compare the impact of the physical environment on patients' activities and care at three newly built stroke units. Receiving care in a stroke unit instead of in a general ward reduces the odds of death, dependency and institutionalized care. In stroke units, the design of the physical environment should support evidence-based care. Studies on patients' activities in relation to the design of the physical environment of stroke units are scarce. This work is a comparative descriptive case study. Patients (N = 55) who had a confirmed diagnosis of stroke were recruited from three newly built stroke units in Sweden. The units were examined by non-participant observation using two types of data collection: behavioural mapping analysed with descriptive statistics and field note taking analysed with deductive content analysis. Data were collected from April 2013 - December 2015. The units differed in the patients' levels of physical activity, the proportion of the day that patients spent with health professionals and family presence. Patients were more physically active in a unit with a combination of single and multi-bed room designs than in a unit with an entirely single-room design. Stroke units that were easy to navigate and offered variations in the physical environment had an impact on patients' activities and care. Patients' activity levels and interactions appeared to vary with the design of the physical environments of stroke units. Stroke guidelines focused on health status assessments, avoidance of bed-rest and early rehabilitation require a supportive physical environment. © 2018 The Authors. Journal of Advanced Nursing Published by John Wiley & Sons Ltd.

Immediate lexical integration of novel word forms

PubMed Central

Kapnoula, Efthymia C.; McMurray, Bob

2014-01-01

It is well known that familiar words inhibit each other during spoken word recognition. However, we do not know how and under what circumstances newly learned words become integrated with the lexicon in order to engage in this competition. Previous work on word learning has highlighted the importance of offline consolidation (Gaskell & Dumay, 2003) and meaning (Leach & Samuel, 2007) to establish this integration. In two experiments we test the necessity of these factors by examining the inhibition between newly learned items and familiar words immediately after learning. Participants learned a set of nonwords without meanings in active (Exp 1) or passive (Exp 2) exposure paradigms. After training, participants performed a visual world paradigm task to assess inhibition from these newly learned items. An analysis of participants’ fixations suggested that the newly learned words were able to engage in competition with known words without any consolidation. PMID:25460382

Immediate lexical integration of novel word forms.

PubMed

Kapnoula, Efthymia C; Packard, Stephanie; Gupta, Prahlad; McMurray, Bob

2015-01-01

It is well known that familiar words inhibit each other during spoken word recognition. However, we do not know how and under what circumstances newly learned words become integrated with the lexicon in order to engage in this competition. Previous work on word learning has highlighted the importance of offline consolidation (Gaskell & Dumay, 2003) and meaning (Leach & Samuel, 2007) to establish this integration. In two experiments we test the necessity of these factors by examining the inhibition between newly learned items and familiar words immediately after learning. Participants learned a set of nonwords without meanings in active (Experiment 1) or passive (Experiment 2) exposure paradigms. After training, participants performed a visual world paradigm task to assess inhibition from these newly learned items. An analysis of participants' fixations suggested that the newly learned words were able to engage in competition with known words without any consolidation. Copyright © 2014 Elsevier B.V. All rights reserved.

Hope, emotion regulation, and psychosocial well-being in patients newly diagnosed with cancer.

PubMed

Peh, Chao Xu; Kua, Ee Heok; Mahendran, Rathi

2016-05-01

Patients newly diagnosed with cancer are often confronted with feelings of uncertainty and life threat. A significant proportion may report impairments in psychosocial well-being. Previous studies examining protective psychological factors such as hope and emotion regulation (ER) have yet to investigate these processes concurrently within a common self-regulation framework and/or focus on newly diagnosed patients. The present study aimed to examine how hope and ER may relate to psychosocial outcomes of patients newly diagnosed with cancer. The present study used a cross-sectional design with self-report questionnaires. Participants were newly diagnosed patients (N = 101) recruited from three cancer therapy clinics in a hospital. Patients completed measures of hope, ER (cognitive reappraisal and expressive suppression), and psychosocial well-being (life satisfaction and negative affectivity). Findings showed that (1) hope and reappraisal, but not suppression, were associated with well-being and (2) the interaction between hope and reappraisal was associated with well-being; reappraisal was not associated with well-being in high hope patients, while high reappraisal was associated with better well-being in low hope patients. Individual differences in hope and reappraisal appeared to be associated with psychosocial outcomes in newly diagnosed cancer patients. Hopeful thinking appeared to benefit patients' psychosocial well-being. In addition, an interaction effect between hope and reappraisal suggested that reappraisal as an ER strategy may be particularly adaptive for patients with low hope.

Optical Sensing to Determine Tomato Plant Spacing for Precise Agrochemical Application: Two Scenarios

PubMed Central

Martínez-Guanter, Jorge; Garrido-Izard, Miguel; Valero, Constantino; Slaughter, David C.; Pérez-Ruiz, Manuel

2017-01-01

The feasibility of automated individual crop plant care in vegetable crop fields has increased, resulting in improved efficiency and economic benefits. A systems-based approach is a key feature in the engineering design of mechanization that incorporates precision sensing techniques. The objective of this study was to design new sensing capabilities to measure crop plant spacing under different test conditions (California, USA and Andalucía, Spain). For this study, three different types of optical sensors were used: an optical light-beam sensor (880 nm), a Light Detection and Ranging (LiDAR) sensor (905 nm), and an RGB camera. Field trials were conducted on newly transplanted tomato plants, using an encoder as a local reference system. Test results achieved a 98% accuracy in detection using light-beam sensors while a 96% accuracy on plant detections was achieved in the best of replications using LiDAR. These results can contribute to the decision-making regarding the use of these sensors by machinery manufacturers. This could lead to an advance in the physical or chemical weed control on row crops, allowing significant reductions or even elimination of hand-weeding tasks. PMID:28492504

Theoretical considerations and measurements for phoropters

NASA Astrophysics Data System (ADS)

Zhang, Jiyan; Liu, Wenli; Sun, Jie

2008-10-01

A phoropter is one of the most popular ophthalmic instruments used in current optometry practice. The quality and verification of the instrument are of the utmost importance. In 1997, International Organization for Standardization published the first ISO standard for requirements of phoropters. However, in China, few standard and test method are suggested for phoropters. Research work on test method for phoropters was carried out early in 2004 by China National Institute of Metrology. In this paper, first, structure of phoropters is described. Then, theoretical considerations for its optical design are analyzed. Next, a newly developed instrument is introduced and measurements are taken. By calibration, the indication error of the instrument is not over 0.05m-1. Finally, measurement results show that the quality situation of phoropters is not as good as expected because of production and assembly error. Optical design shall be improved especially for combinations of both spherical and cylindrical lenses with higher power. Besides, optical requirements specified in ISO standard are found to be a little strict and hard to meet. A proposal for revision of this international standard is drafted and discussed on ISO meeting of 2007 held in Tokyo.

Report on Cosmic Dust Capture Research and Development for the Exobiology Program

NASA Technical Reports Server (NTRS)

Nishioka, Kenji

1997-01-01

Collaboration with Ames' personnel was in: 1) grant administration, 2) intellectual science support, 3) collaboration with the University of Paris for the Mir flight experiment, and 4) arranging scanning and X-ray probe analytical support from UCB and SUNYP. LNIMS provided access to: 1) analytical research instruments, 2) chemical analyses support, 3) cleanroom facilities, and 4) design and fabrication expertise of hardware and electronics. They also supported the hypervelocity testing along with test data acquisition and its reduction for the breadboard instrument. A&M Associates provided technical expertise and support on determining the expected charges on orbital particles and a conceptual design for a breadboard particle charge detection sensor. University of California provided analytical support for the recovered Mir flight modules using their unique scanning capability to detect particle tracks in the aerogel. SUNYP, along with help from the University of Chicago, analyzed particle tracks found in the aerogel for biogenic compounds using an x-ray probe instrument. Dr. Schultz provided access to his experiments and the benefits of his considerable hyper-velocity testing expertise at the Ames hypervelocity gun facility, and this proved beneficial to our development testing, significantly reducing the test time and cost for the breadboard instrument development testing. The participants in this activity acknowledge and thank the National Aeronautics and Space Administration and its Ames Research Center for providing the necessary support and resources to conduct this investigation on instrument technology for exobiology application and being able to acquire some interesting results. Primarily, the newly identified technology problems for future research are the important results of this research.

Randomized trial of proactive rapid genetic counseling versus usual care for newly diagnosed breast cancer patients.

PubMed

Schwartz, Marc D; Peshkin, Beth N; Isaacs, Claudine; Willey, Shawna; Valdimarsdottir, Heiddis B; Nusbaum, Rachel; Hooker, Gillian; O'Neill, Suzanne; Jandorf, Lina; Kelly, Scott P; Heinzmann, Jessica; Zidell, Aliza; Khoury, Katia

2018-08-01

Breast cancer patients who carry BRCA1/BRCA2 gene mutations may consider bilateral mastectomy. Having bilateral mastectomy at the time of diagnosis not only reduces risk of a contralateral breast cancer, but can eliminate the need for radiation therapy and yield improved reconstruction options. However, most patients do not receive genetic counseling or testing at the time of their diagnosis. In this trial, we tested proactive rapid genetic counseling and testing (RGCT) in newly diagnosed breast cancer patients in order to facilitate pre-surgical genetic counseling and testing. We recruited newly diagnosed breast cancer patients at increased risk for carrying a BRCA1/2 mutation. Of 379 eligible patients who completed a baseline survey, 330 agreed to randomization in a 2:1 ratio to RGCT (n = 220) versus UC (n = 108). Primary outcomes were genetic counseling and testing uptake and breast cancer surgical decisions. RGCT led to higher overall (83.8% vs. 54.6%; p < 0.0001) and pre-surgical (57.8% vs. 38.7%; p = 0.001) genetic counseling uptake compared to UC. Despite higher rates of genetic counseling, RGCT did not differ from UC in overall (54.1% vs. 49.1%, p > 0.10) or pre-surgical (30.6% vs. 27.4%, p > 0.10) receipt of genetic test results nor did they differ in uptake of bilateral mastectomy (26.6% vs. 21.8%, p > 0.10). Although RGCT yielded increased genetic counseling participation, this did not result in increased rates of pre-surgical genetic testing or impact surgical decisions. These data suggest that those patients most likely to opt for genetic testing at the time of diagnosis are being effectively identified by their surgeons.

Effects of topiramate on language functions in newly diagnosed pediatric epileptic patients.

PubMed

Kim, Sun Jun; Kim, Moon Yeon; Choi, Yoon Mi; Song, Mi Kyoung

2014-09-01

The aim of this study was to characterize the effects of topiramate on language functions in newly diagnosed pediatric epileptic patients. Thirty-eight newly diagnosed epileptic patients were assessed using standard language tests. Data were collected before and after beginning topiramate during which time a monotherapy treatment regimen was maintained. Language tests included the Test of Language Problem Solving Abilities, a Korean version of the Peabody Picture Vocabulary Test. We used language tests in the Korean version because all the patients were spoken Korean exclusively in their families. All the language parameters of Test of Language Problem Solving Abilities worsened after initiation of topiramate (determine cause, 13.2 ± 4.8 to 11.2 ± 4.3; problem solving, 14.8 ± 6.0 to 12.8 ± 5.0; predicting, 9.8 ± 3.6 to 8.8 ± 4.6). Patients given topiramate exhibited a shortened mean length of utterance in words during response (determine cause, 4.8 ± 0.9 to 4.3 ± 0.7; making inference, 4.5 ± 0.8 to 4.1 ± 1.1; predicting, 5.2 ± 1.0 to 4.7 ± 0.6; P < 0.05), provided ambiguous answers during the testing, exhibited difficulty in selecting appropriate words, took more time to provide answers, and used incorrect grammar. However, there were no statistically significant changes in the receptive language of patients after taking topiramate (95.4 ± 20.4 to 100.8 ± 19.1). Our data suggest that topiramate may have negative effects on problem-solving abilities in children. We recommend performing language tests should be considered in children being treated with topiramate. Copyright © 2014 Elsevier Inc. All rights reserved.

SOCR Analyses - an Instructional Java Web-based Statistical Analysis Toolkit.

PubMed

Chu, Annie; Cui, Jenny; Dinov, Ivo D

2009-03-01

The Statistical Online Computational Resource (SOCR) designs web-based tools for educational use in a variety of undergraduate courses (Dinov 2006). Several studies have demonstrated that these resources significantly improve students' motivation and learning experiences (Dinov et al. 2008). SOCR Analyses is a new component that concentrates on data modeling and analysis using parametric and non-parametric techniques supported with graphical model diagnostics. Currently implemented analyses include commonly used models in undergraduate statistics courses like linear models (Simple Linear Regression, Multiple Linear Regression, One-Way and Two-Way ANOVA). In addition, we implemented tests for sample comparisons, such as t-test in the parametric category; and Wilcoxon rank sum test, Kruskal-Wallis test, Friedman's test, in the non-parametric category. SOCR Analyses also include several hypothesis test models, such as Contingency tables, Friedman's test and Fisher's exact test.The code itself is open source (http://socr.googlecode.com/), hoping to contribute to the efforts of the statistical computing community. The code includes functionality for each specific analysis model and it has general utilities that can be applied in various statistical computing tasks. For example, concrete methods with API (Application Programming Interface) have been implemented in statistical summary, least square solutions of general linear models, rank calculations, etc. HTML interfaces, tutorials, source code, activities, and data are freely available via the web (www.SOCR.ucla.edu). Code examples for developers and demos for educators are provided on the SOCR Wiki website.In this article, the pedagogical utilization of the SOCR Analyses is discussed, as well as the underlying design framework. As the SOCR project is on-going and more functions and tools are being added to it, these resources are constantly improved. The reader is strongly encouraged to check the SOCR site for most updated information and newly added models.

A preliminary study of bending stiffness alteration in shape changing nitinol plates for fracture fixation.

PubMed

Olender, Gavin; Pfeifer, Ronny; Müller, Christian W; Gösling, Thomas; Barcikowski, Stephan; Hurschler, Christof

2011-05-01

Nitinol is a promising biomaterial based on its remarkable shape changing capacity, biocompatibility, and resilient mechanical properties. Until now, very limited applications have been tested for the use of Nitinol plates for fracture fixation in orthopaedics. Newly designed fracture-fixation plates are tested by four-point bending to examine a change in equivalent bending stiffness before and after shape transformation. The goal of stiffness alterable bone plates is to optimize the healing process during osteosynthesis in situ that is customized in time of onset, percent change as well as being performed non-invasively for the patient. The equivalent bending stiffness in plates of varying thicknesses changed before and after shape transformation in the range of 24-73% (p values <0.05 for all tests). Tests on a Nitinol plate of 3.0 mm increased in stiffness from 0.81 to 0.98 Nm² (corresponding standard deviation 0.08 and 0.05) and shared a good correlation to results from numerical calculation. The stiffness of the tested fracture-fixation plates can be altered in a consistent matter that would be predicted by determining the change of the cross-sectional area moment of inertia.

The Development of a Gas–Liquid Two-Phase Flow Sensor Applicable to CBM Wellbore Annulus

PubMed Central

Wu, Chuan; Wen, Guojun; Han, Lei; Wu, Xiaoming

2016-01-01

The measurement of wellbore annulus gas–liquid two-phase flow in CBM (coalbed methane) wells is of great significance for reasonably developing gas drainage and extraction processes, estimating CBM output, judging the operating conditions of CBM wells and analyzing stratum conditions. Hence, a specially designed sensor is urgently needed for real-time measurement of gas–liquid two-phase flow in CBM wellbore annulus. Existing flow sensors fail to meet the requirements of the operating conditions of CBM wellbore annulus due to such factors as an inapplicable measurement principle, larger size, poor sealability, high installation accuracy, and higher requirements for fluid media. Therefore, based on the principle of a target flowmeter, this paper designs a new two-phase flow sensor that can identify and automatically calibrate different flow patterns of two-phase flows. Upon the successful development of the new flow sensor, lab and field tests were carried out, and the results show that the newly designed sensor, with a measurement accuracy of ±2.5%, can adapt to the operating conditions of CBM wells and is reliable for long-term work. PMID:27869708

The Development of a Gas-Liquid Two-Phase Flow Sensor Applicable to CBM Wellbore Annulus.

PubMed

Wu, Chuan; Wen, Guojun; Han, Lei; Wu, Xiaoming

2016-11-18

The measurement of wellbore annulus gas-liquid two-phase flow in CBM (coalbed methane) wells is of great significance for reasonably developing gas drainage and extraction processes, estimating CBM output, judging the operating conditions of CBM wells and analyzing stratum conditions. Hence, a specially designed sensor is urgently needed for real-time measurement of gas-liquid two-phase flow in CBM wellbore annulus. Existing flow sensors fail to meet the requirements of the operating conditions of CBM wellbore annulus due to such factors as an inapplicable measurement principle, larger size, poor sealability, high installation accuracy, and higher requirements for fluid media. Therefore, based on the principle of a target flowmeter, this paper designs a new two-phase flow sensor that can identify and automatically calibrate different flow patterns of two-phase flows. Upon the successful development of the new flow sensor, lab and field tests were carried out, and the results show that the newly designed sensor, with a measurement accuracy of ±2.5%, can adapt to the operating conditions of CBM wells and is reliable for long-term work.

Design of polarizers for a mega-watt long-pulse millimeter-wave transmission line on the large helical device.

PubMed

Ii, T; Kubo, S; Shimozuma, T; Kobayashi, S; Okada, K; Yoshimura, Y; Igami, H; Takahashi, H; Ito, S; Mizuno, Y; Okada, K; Makino, R; Kobayashi, K; Goto, Y; Mutoh, T

2015-02-01

The polarizer is one of the critical components in a high-power millimeter-wave transmission line. It requires full and highly efficient coverage of any polarization states, high-power tolerance, and low-loss feature. Polarizers with rounded shape at the edge of the periodic groove surface are designed and fabricated by the machining process for a mega-watt long-pulse millimeter-wave transmission line of the electron cyclotron resonance heating system in the large helical device. The groove shape of λ/8- and λ/4-type polarizers for an 82.7 GHz transmission line is optimally designed in an integral method developed in the vector theories of diffraction gratings so that the efficiency to realize any polarization state can be maximized. The dependence of the polarization states on the combination of the two polarizer rotation angles (Φλ/8, Φλ/4) is examined experimentally in a low-power test with the newly developed polarization monitor. The results show that the measured polarization characteristics are in good agreement with the calculated ones.

Systematic Review of Decision Aids for Newly Diagnosed Patients with Prostate Cancer Making Treatment Decisions.

PubMed

Adsul, Prajakta; Wray, Ricardo; Spradling, Kyle; Darwish, Oussama; Weaver, Nancy; Siddiqui, Sameer

2015-11-01

Despite established evidence for using patient decision aids, use with newly diagnosed patients with prostate cancer remains limited partly due to variability in aid characteristics. We systematically reviewed decision aids for newly diagnosed patients with prostate cancer. Published peer reviewed journal articles, unpublished literature on the Internet and the Ottawa decision aids web repository were searched to identify decision aids designed for patients with prostate cancer facing treatment decisions. A total of 14 aids were included in study. Supplementary materials on aid development and published studies evaluating the aids were also included. We studied aids designed to help patients make specific choices among options and outcomes relevant to health status that were specific to prostate cancer treatment and in English only. Aids were reviewed for IPDAS (International Patient Decision Aid Standards) and additional standards deemed relevant to prostate cancer treatment decisions. They were also reviewed for novel criteria on the potential for implementation. Acceptable interrater reliability was achieved at Krippendorff α = 0.82. Eight of the 14 decision aids (57.1%) were developed in the United States, 6 (42.8%) were print based, 5 (35.7%) were web or print based and only 4 (28.5%) had been updated since 2013. Ten aids (71.4%) were targeted to prostate cancer stage. All discussed radiation and surgery, 10 (71.4%) discussed active surveillance and/or watchful waiting and 8 (57.1%) discussed hormonal therapy. Of the aids 64.2% presented balanced perspectives on treatment benefits and risks, and/or outcome probabilities associated with each option. Ten aids (71.4%) presented value clarification prompts for patients and steps to make treatment decisions. No aid was tested with physicians and only 4 (28.6%) were tested with patients. Nine aids (64.2%) provided details on data appraisal and 4 (28.6%) commented on the quality of evidence used. Seven of the 8 web or computer based aids (87.5%) provided patients with the opportunity to interact with the aid. All except 1 aid scored above the 9th grade reading level. No evidence on aid implementation in routine practice was available. As physicians look to adopt decision aids in practice, they may base the choice of aid on characteristics that correlate with patient socioeconomic and educational status, personal practice style and practice setting. Copyright © 2015 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

New Rock Abrasivity Test Method for Tool Life Assessments on Hard Rock Tunnel Boring: The Rolling Indentation Abrasion Test (RIAT)

NASA Astrophysics Data System (ADS)

Macias, F. J.; Dahl, F.; Bruland, A.

2016-05-01

The tunnel boring machine (TBM) method has become widely used and is currently an important presence within the tunnelling industry. Large investments and high geological risk are involved using TBMs, and disc cutter consumption has a great influence on performance and cost, especially in hard rock conditions. Furthermore, reliable cutter life assessments facilitate the control of risk as well as avoiding delays and budget overruns. Since abrasive wear is the most common process affecting cutter consumption, good laboratory tests for rock abrasivity assessments are needed. A new abrasivity test method by rolling disc named Rolling Indentation Abrasion Test (RIAT) has been developed. The goal of the new test design and procedure is to reproduce wear behaviour on hard rock tunnel boring in a more realistic way than the traditionally used methods. Wear by rolling contact on intact rock samples is introduced and several rock types, covering a wide rock abrasiveness range, have been tested by RIAT. The RIAT procedure indicates a great ability of the testing method to assess abrasive wear on rolling discs. In addition and to evaluate the newly developed RIAT test method, a comprehensive laboratory testing programme including the most commonly used abrasivity test methods and the mineral composition were carried out. Relationships between the achieved results from conventional testing and RIAT results have been analysed.

On Design and Implementation of Neural-Machine Interface for Artificial Legs

PubMed Central

Zhang, Xiaorong; Liu, Yuhong; Zhang, Fan; Ren, Jin; Sun, Yan (Lindsay); Yang, Qing

2011-01-01

The quality of life of leg amputees can be improved dramatically by using a cyber physical system (CPS) that controls artificial legs based on neural signals representing amputees’ intended movements. The key to the CPS is the neural-machine interface (NMI) that senses electromyographic (EMG) signals to make control decisions. This paper presents a design and implementation of a novel NMI using an embedded computer system to collect neural signals from a physical system - a leg amputee, provide adequate computational capability to interpret such signals, and make decisions to identify user’s intent for prostheses control in real time. A new deciphering algorithm, composed of an EMG pattern classifier and a post-processing scheme, was developed to identify the user’s intended lower limb movements. To deal with environmental uncertainty, a trust management mechanism was designed to handle unexpected sensor failures and signal disturbances. Integrating the neural deciphering algorithm with the trust management mechanism resulted in a highly accurate and reliable software system for neural control of artificial legs. The software was then embedded in a newly designed hardware platform based on an embedded microcontroller and a graphic processing unit (GPU) to form a complete NMI for real time testing. Real time experiments on a leg amputee subject and an able-bodied subject have been carried out to test the control accuracy of the new NMI. Our extensive experiments have shown promising results on both subjects, paving the way for clinical feasibility of neural controlled artificial legs. PMID:22389637

Status of high temperature superconductor cable and fault current limiter projects at American Superconductor

NASA Astrophysics Data System (ADS)

Maguire, J. F.; Yuan, J.

2009-10-01

This paper will describe the status of three key programs currently underway at American Superconductor Corp. The first program is the LIPA project which is a transmission voltage high temperature superconducting cable program, with funding support from the US Department of Energy. The 600 m cable, capable of carrying 574 MVA, was successfully installed and commissioned in LIPA grid on April 22, 2008. An overview of the project, system level design details and operational data will be provided. In addition, the status of the newly awarded LIPA II project will be described. The second program is Project Hydra, with funding support from the US Department of Homeland Security, to design, develop and demonstrate an HTS cable with fault current limiting functionality. The cable is 300 m long and is being designed to carry 96 MVA at a distribution level voltage of 13.8 kV. The cable will be permanently installed and energized in Manhattan, New York in 2010. The initial status of Project Hydra will be presented. The final program to be discussed is a transmission voltage, high temperature superconducting fault current limiter funded by the US DOE. The project encompasses the design, construction and test of a 115 kV FCL for power transmission within a time frame of 4-5 years. Installation and testing are planned for a Southern California Edison substation. A project overview and progress under the first phase will be reported.

Newly graduated nurses' empowerment regarding professional competence and other work-related factors.

PubMed

Kuokkanen, Liisa; Leino-Kilpi, Helena; Numminen, Olivia; Isoaho, Hannu; Flinkman, Mervi; Meretoja, Riitta

2016-01-01

Although both nurse empowerment and competence are fundamental concepts of describing newly graduated nurses' professional development and job satisfaction, only few studies exist on the relationship between these concepts. Therefore, the purpose of this study was to determine how newly graduated nurses assess their empowerment and to clarify professional competence compared to other work-related factors. A descriptive, cross-sectional and correlational design was applied. The sample comprised newly graduated nurses (n = 318) in Finland. Empowerment was measured using the 19-item Qualities of an Empowered Nurse scale and the Nurse Competence Scale measured nurses' self-assessed generic competence. In addition to demographic data, the background data included employment sector (public/private), job satisfaction, intent to change/leave job, work schedule (shifts/business hours) and assessments of the quality of care in the workplace. The data were analysed statistically by using Spearman's correlation coefficient as well as the One-Way and Multivariate Analysis of Variance. Cronbach's alpha coefficient was used to estimate the internal consistency. Newly graduated nurses perceived their level of empowerment and competence fairly high. The association between nurse empowerment and professional competence was statistically significant. Other variables correlating positively to empowerment included employment sector, age, job satisfaction, intent to change job, work schedule, and satisfaction with the quality of care in the work unit. The study indicates competence had the strongest effect on newly graduated nurses' empowerment. New graduates need support and career opportunities. In the future, nurses' further education and nurse managers' resources for supporting and empowering nurses should respond to the newly graduated nurses' requisites for attractive and meaningful work.

Modern fiber laser beam welding of the newly-designed precipitation-strengthened nickel-base superalloys

NASA Astrophysics Data System (ADS)

Naffakh Moosavy, Homam; Aboutalebi, Mohammad-Reza; Seyedein, Seyed Hossein; Goodarzi, Massoud; Khodabakhshi, Meisam; Mapelli, Carlo; Barella, Silvia

2014-04-01

In the present research, the modern fiber laser beam welding of newly-designed precipitation-strengthened nickel-base superalloys using various welding parameters in constant heat input has been investigated. Five nickel-base superalloys with various Ti and Nb contents were designed and produced by Vacuum Induction Melting furnace. The fiber laser beam welding operations were performed in constant heat input (100 J mm-2) and different welding powers (400 and 1000 W) and velocities (40 and 100 mm s-1) using 6-axis anthropomorphic robot. The macro- and micro-structural features, weld defects, chemical composition and mechanical property of 3.2 mm weldments were assessed utilizing optical and scanning electron microscopes equipped with EDS analysis and microhardness tester. The results showed that welding with higher powers can create higher penetration-to-width ratios. The porosity formation was increased when the welding powers and velocities were increased. None of the welds displayed hot solidification and liquation cracks in 400 and 1000 W welding powers, but liquation phenomenon was observed in all the heat-affected zones. With increasing the Nb content of the superalloys the liquation length was increased. The changing of the welding power and velocity did not alter the hardness property of the welds. The hardness of welds decreased when the Ti content declined in the composition of superalloys. Finally, the 400 and 1000 W fiber laser powers with velocity of 40 and 100 m ms-1 have been offered for hot crack-free welding of the thin sheet of newly-designed precipitation-strengthened nickel-base superalloys.

Evaluating the Physiological and Perceptual Responses of Wearing a Newly Designed Cooling Vest for Construction Workers.

PubMed

Zhao, Yijie; Yi, Wen; Chan, Albert P C; Wong, Francis K W; Yam, Michael C H

2017-08-01

Construction workers are subjected to heat stress because of the hot environment, physically demanding tasks, and/or personal protective equipment. A tailor-made cooling vest that protects construction workers from heat-related injuries was developed. The purpose of the study is to examine a newly designed cooling vest's effectiveness in alleviating physiological and perceptual strain in a hot and humid environment. Twelve male participants performed two trials, i.e., cooling vest (VEST) and control (CON) in a climatic chamber controlled at 37°C temperature, 60% relative humidity, 0.3 m/s air velocity, and 450 W/m2 solar radiation to simulate the summer working environment of construction sites. Two bouts of treadmill exercise intermitted with 30-minute passive recovery were designed to simulate the practical work-rest schedule of the construction industry. The cooling vest was used during the passive recovery period in the VEST condition, and the results were compared with that of no cooling vest in the CON condition. The results revealed that the newly designed cooling vest can significantly alleviate heat strain and improve thermal comfort, based on the decrease in body temperature, heart rate, and subjective perceptions (including perceived exertion, thermal, wetness, and comfort sensation) of the participants. It can also prolong work duration in the subsequent exercise. The cooling countermeasures proposed in this study will be able to provide an effective solution in situations that involve repeated bouts of outdoor construction work. © The Author 2017. Published by Oxford University Press on behalf of the British Occupational Hygiene Society.

Development of the Flight Tether for ProSEDS

NASA Technical Reports Server (NTRS)

Curtis, Leslie; Vaughn, Jason; Welzyn, Ken; Carroll, Joe; Brown, Norman S. (Technical Monitor)

2002-01-01

The Propulsive Small Expendable Deployer System (ProSEDS) space experiment will demonstrate the use of an electrodynamic tether propulsion system to generate thrust in space by decreasing the orbital altitude of a Delta 11 Expendable Launch Vehicle second stage. ProSEDS will use the flight-proven Small Expendable Deployer System to deploy a newly designed and developed tether which will provide tether generated drag thrust of approx. 0.4 N. The development and production of very long tethers with specific properties for performance and survivability will be required to enable future tether missions. The ProSEDS tether design and the development process may provide some lessons learned for these future missions. The ProSEDS system requirements drove the design of the tether to have three different sections of tether each serving a specialized purpose. The tether is a total of 15 kilometers long: 10 kilometers of a non-conductive Dyneema lead tether; 5 km of CCOR conductive coated wire; and 220 meters of insulated wire with a protective Kevlar overbraid. Production and joining of long tether lengths involved many development efforts. Extensive testing of tether materials including ground deployment of the full-length ProSEDS tether was conducted to validate the tether design and performance before flight.

Design of a surgical instrument for removing bone to provide screw access to a spinal fusion cage.

PubMed

Jabbary Aslani, F; Hukins, D W L; Shepherd, D E T; Parry, J J; Fennell, A J; Lambell, S

2012-01-01

A surgical instrument to aid implantation of a range of lumbar spinal fusion cages has been developed. Once the cage is in position, the entrance to screw holes is partially blocked by the edge of the vertebral body. In order to insert fixation screws to secure the cage between the vertebrae, some part of the blocking edge has to be removed. Rongeurs are currently being used, but they can be time consuming and have the disadvantage that they may remove more bone than is necessary and may cause damage to the fusion cage if not used with care. In addition, access around some of the screw holes may be difficult. The aim of this instrument was to overcome these shortcomings. This paper describes the design of a surgical instrument for cutting edges from vertebral bodies. The development and evaluation of concept designs are presented and discussed. Potential risks were considered and modifications were performed on the selected concept. Functional prototypes were manufactured and tested on sheep lumbar vertebrae. The results showed that the newly designed cutting instrument functions as required and removes the required amount of bone from the vertebral body edge.

Environmental metabarcodes for insects: in silico PCR reveals potential for taxonomic bias.

PubMed

Clarke, Laurence J; Soubrier, Julien; Weyrich, Laura S; Cooper, Alan

2014-11-01

Studies of insect assemblages are suited to the simultaneous DNA-based identification of multiple taxa known as metabarcoding. To obtain accurate estimates of diversity, metabarcoding markers ideally possess appropriate taxonomic coverage to avoid PCR-amplification bias, as well as sufficient sequence divergence to resolve species. We used in silico PCR to compare the taxonomic coverage and resolution of newly designed insect metabarcodes (targeting 16S) with that of existing markers [16S and cytochrome oxidase c subunit I (COI)] and then compared their efficiency in vitro. Existing metabarcoding primers amplified in silico <75% of insect species with complete mitochondrial genomes available, whereas new primers targeting 16S provided >90% coverage. Furthermore, metabarcodes targeting COI appeared to introduce taxonomic PCR-amplification bias, typically amplifying a greater percentage of Lepidoptera and Diptera species, while failing to amplify certain orders in silico. To test whether bias predicted in silico was observed in vitro, we created an artificial DNA blend containing equal amounts of DNA from 14 species, representing 11 insect orders and one arachnid. We PCR-amplified the blend using five primer sets, targeting either COI or 16S, with high-throughput amplicon sequencing yielding more than 6 million reads. In vitro results typically corresponded to in silico PCR predictions, with newly designed 16S primers detecting 11 insect taxa present, thus providing equivalent or better taxonomic coverage than COI metabarcodes. Our results demonstrate that in silico PCR is a useful tool for predicting taxonomic bias in mixed template PCR and that researchers should be wary of potential bias when selecting metabarcoding markers. © 2014 John Wiley & Sons Ltd.

Translating access into utilization: lessons from the design and evaluation of a health insurance Web site to promote reproductive health care for young women in Massachusetts.

PubMed

Janiak, Elizabeth; Rhodes, Elizabeth; Foster, Angel M

2013-12-01

Following state-level health care reform in Massachusetts, young women reported confusion over coverage of contraception and other sexual and reproductive health services under newly available health insurance products. To address this gap, a plain-language Web site titled "My Little Black Book for Sexual Health" was developed by a statewide network of reproductive health stakeholders. The purpose of this evaluation was to assess the health literacy demands and usability of the site among its target audience, women ages 18-26 years. We performed an evaluation of the literacy demands of the Web site's written content and tested the Web site's usability in a health communications laboratory. Participants found the Web site visually appealing and its overall design concept accessible. However, the Web site's literacy demands were high, and all participants encountered problems navigating through the Web site. Following this evaluation, the Web site was modified to be more usable and more comprehensible to women of all health literacy levels. To avail themselves of sexual and reproductive health services newly available under expanded health insurance coverage, young women require customized educational resources that are rigorously evaluated to ensure accessibility. To maximize utilization of reproductive health services under expanded health insurance coverage, US women require customized educational resources commensurate with their literacy skills. The application of established research methods from the field of health communications will enable advocates to evaluate and adapt these resources to best serve their targeted audiences. © 2013.

Biomechanical analysis of a newly designed bioabsorbable anterior cervical plate. Invited submission from the joint section meeting on disorders of the spine and peripheral nerves, March 2005.

PubMed

Ames, Christopher P; Acosta, Frank L; Chamberlain, Robert H; Larios, Adolfo Espinoza; Crawford, Neil R

2005-12-01

The authors present a biomechanical analysis of a newly designed bioabsorbable anterior cervical plate (ACP) for the treatment of one-level cervical degenerative disc disease. They studied anterior cervical discectomy and fusion (ACDF) in a human cadaveric model, comparing the stability of the cervical spine after placement of the bioabsorbable fusion plate, a bioabsorbable mesh, and a more traditional metallic ACP. Seven human cadaveric specimens underwent a C6-7 fibular graft-assisted ACDF placement. A one-level resorbable ACP was then placed and secured with bioabsorbable screws. Flexibility testing was performed on both intact and instrumented specimens using a servohydraulic system to create flexion-extension, lateral bending, and axial rotation motions. After data analysis, three parameters were calculated: angular range of motion, lax zone, and stiff zone. The results were compared with those obtained in a previous study of a resorbable fusion mesh and with those acquired using metallic fusion ACPs. For all parameters studied, the resorbable plate consistently conferred greater stability than the resorbable mesh. Moreover, it offered comparable stability with that of metallic fusion ACPs. Bioabsorbable plates provide better stability than resorbable mesh. Although the results of this study do not necessarily indicate that a resorbable plate confers equivalent stability to a metal plate, the resorbable ACP certainly yielded better results than the resorbable mesh. Bioabsorbable fusion ACPs should therefore be considered as alternatives to metal plates when a graft containment device is required.

Integrating Tobacco Treatment into Cancer Care: Study Protocol for a Randomized Controlled Comparative Effectiveness Trial

PubMed Central

Park, Elyse R.; Ostroff, Jamie S.; Perez, Giselle K.; Hyland, Kelly A.; Rigotti, Nancy A.; Borderud, Sarah; Regan, Susan; Muzikansky, Alona; Friedman, Emily R.; Levy, Douglas E.; Holland, Susan; Eusebio, Justin; Peterson, Lisa; Rabin, Julia; Miller-Sobel, Jacob; Gonzalez, Irina; Malloy, Laura; O’Brien, Maureen; de León-Sanchez, Suhana; Will Whitlock, C.

2016-01-01

Background Despite the well-established risks of persistent smoking, 10-30% of cancer patients continue to smoke after diagnosis. Evidence based tobacco treatment has yet to be integrated into routine oncology care. This paper describes the protocol, manualized treatment, evaluation plan, and overall study design of comparing the effectiveness and cost of two treatments across two major cancer centers. Methods/Design A two-arm, two-site randomized controlled comparative effectiveness trial is testing the hypothesis that an Intensive Treatment (IT) intervention is more effective than a Standard Treatment (ST) intervention in helping recently diagnosed cancer patients quit smoking. Both interventions include 4 weekly counseling sessions and FDA-approved smoking cessation medication advice. The IT includes an additional 4 biweekly and 3 monthly booster sessions as well as dispensal of the recommended FDA-approved smoking cessation medication at no cost. The trial is enrolling patients with suspected or newly diagnosed cancer who have smoked a cigarette in the past 30 days. Participants are randomly assigned to receive the ST or IT condition. Tobacco cessation outcomes are assessed at 3 and 6 months. The primary study outcome is 7-day point prevalence biochemically-validated tobacco abstinence. Secondary study outcomes include the incremental cost-effectiveness of the IT vs. ST. Discussion This trial will answer key questions about delivering tobacco treatment interventions to newly diagnosed cancer patients. If found to be efficacious and cost-effective, this treatment will serve as a model to be integrated into oncology care settings nation-wide, as we strive to improve treatment outcomes and quality of life for cancer patients. PMID:27444428

Catheter-based tricuspid valve replacement: first experimental data of a newly designed bileaflet stent graft prosthesis.

PubMed

Lausberg, Henning F; Gryszkiewicz, Rafal; Kuetting, Maximilian; Baumgaertner, Moritz; Centola, Marcos; Wendel, Hans-Peter; Nowak-Machen, Martina; Schibilsky, David; Kruger, Tobias; Schlensak, Christian

2017-07-01

Moderate or severe degree tricuspid valve regurgitation (TVR) is associated with high rates of morbidity and mortality. Surgical correction as the only therapeutic option offers unsatisfactory results. Recently, several interventional procedures have been introduced clinically in a limited cohort. We present our initial experiments with an innovative interventional valved stent graft for treatment of TVR. A newly designed porcine pericardium-covered nitinol stent graft with a lateral bicuspid valve was adapted to size in a cadaver study. After haemodynamic testing in an ex vivo perfusion setup, vascular access, valve delivery and function were investigated in an ovine animal model ( n  = 7). The device was implanted successfully in all animals. Vascular access was established surgically via the femoral vein without any vascular complications. Angiography demonstrated the correct position of the device with proper sealing of both venae cavae in 6 animals. In 1 extremely large animal, the position of the device was considered too cranial but still acceptable. Correct valve function was verified in all animals by both angiography and echocardiography. There were no persistent arrhythmias other than during valve implant. All animals survived the implant procedure and were sacrificed electively. This study demonstrated that this new valved stent graft could be delivered safely with correct positioning and valve function in this ovine model. Further long-term studies in animals implanted with the device after creation of tricuspid regurgitation are necessary to prove the haemodynamic benefit of this procedure. © The Author 2017. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.

Reducing temperature elevation of robotic bone drilling.

PubMed

Feldmann, Arne; Wandel, Jasmin; Zysset, Philippe

2016-12-01

This research work aims at reducing temperature elevation of bone drilling. An extensive experimental study was conducted which focused on the investigation of three main measures to reduce the temperature elevation as used in industry: irrigation, interval drilling and drill bit designs. Different external irrigation rates (0 ml/min, 15 ml/min, 30 ml/min), continuously drilled interval lengths (2 mm, 1 mm, 0.5 mm) as well as two drill bit designs were tested. A custom single flute drill bit was designed with a higher rake angle and smaller chisel edge to generate less heat compared to a standard surgical drill bit. A new experimental setup was developed to measure drilling forces and torques as well as the 2D temperature field at any depth using a high resolution thermal camera. The results show that external irrigation is a main factor to reduce temperature elevation due not primarily to its effect on cooling but rather due to the prevention of drill bit clogging. During drilling, the build up of bone material in the drill bit flutes result in excessive temperatures due to an increase in thrust forces and torques. Drilling in intervals allows the removal of bone chips and cleaning of flutes when the drill bit is extracted as well as cooling of the bone in-between intervals which limits the accumulation of heat. However, reducing the length of the drilled interval was found only to be beneficial for temperature reduction using the newly designed drill bit due to the improved cutting geometry. To evaluate possible tissue damage caused by the generated heat increase, cumulative equivalent minutes (CEM43) were calculated and it was found that the combination of small interval length (0.5 mm), high irrigation rate (30 ml/min) and the newly designed drill bit was the only parameter combination which allowed drilling below the time-thermal threshold for tissue damage. In conclusion, an optimized drilling method has been found which might also enable drilling in more delicate procedures such as that performed during minimally invasive robotic cochlear implantation. Copyright © 2016 IPEM. Published by Elsevier Ltd. All rights reserved.

Seed Placement into Veggie Pods

NASA Image and Video Library

2018-02-27

From left, Matthew Romeyn and Dr. Ye Zhang, project scientists, place seeds in Veggie Passive Orbital Nutrient Delivery System (PONDS) units inside a laboratory at the Space Station Processing Facility at NASA’s Kennedy Space Center in Florida. Veggie PONDS is a direct follow-on to the Veg-01 and Veg-03 hardware and plant growth validation tests. The primary goal of this newly developed plant growing system, Veggie PONDS, is to demonstrate uniform plant growth. PONDS units have features that are designed to mitigate microgravity effects on water distribution, increase oxygen exchange and provide sufficient room for root zone growth. PONDS is planned for use during Veg-04 and Veg-05 on the International Space Station after the Veggie PONDS Validation flights on SpaceX-14 and OA-9.

Seed Placement into Veggie Pods

NASA Image and Video Library

2018-02-27

Dr. Ye Zhang, a project scientists, places seeds in Veggie Passive Orbital Nutrient Delivery System (PONDS) units inside a laboratory at the Space Station Processing Facility at NASA's Kennedy Space Center in Florida. Veggie PONDS is a direct follow-on to the Veg-01 and Veg-03 hardware and plant growth validation tests. The primary goal of this newly developed plant growing system, Veggie PONDS, is to demonstrate uniform plant growth. PONDS units have features that are designed to mitigate microgravity effects on water distribution, increase oxygen exchange and provide sufficient room for root zone growth. PONDS is planned for use during Veg-04 and Veg-05 on the International Space Station after the Veggie PONDS Validation flights on SpaceX-14 and OA-9.

The hammer QSD-quick stop device for high speed machining and rubbing

NASA Technical Reports Server (NTRS)

Black, J. T.; James, C. R.

1980-01-01

A quick stop device (QSD) was designed for use in orthogonal machining and rubbing experiments. QSD's are used to obtain chip root samples that are representative of the deformation taking place during dynamic (actual) cutting conditions. These 'frozen' specimens are helpful in examining the plastic deformation that occurs in the regions of compression and shear which form the chip; the secondary shear at the tool-chip interface; and the nose ploughing/flank rubbing action which operates on the newly machined surface. The Hammer QSD employs a shear pin mechanism, broken by a flying hammer, which is traveling at the same velocity as the workpiece. The device has been successfully tested up to 6000 sfpm (30.48 m/sec).

Some properties of a 5-parameter bivariate probability distribution

NASA Technical Reports Server (NTRS)

Tubbs, J. D.; Brewer, D. W.; Smith, O. E.

1983-01-01

A five-parameter bivariate gamma distribution having two shape parameters, two location parameters and a correlation parameter was developed. This more general bivariate gamma distribution reduces to the known four-parameter distribution. The five-parameter distribution gives a better fit to the gust data. The statistical properties of this general bivariate gamma distribution and a hypothesis test were investigated. Although these developments have come too late in the Shuttle program to be used directly as design criteria for ascent wind gust loads, the new wind gust model has helped to explain the wind profile conditions which cause large dynamic loads. Other potential applications of the newly developed five-parameter bivariate gamma distribution are in the areas of reliability theory, signal noise, and vibration mechanics.

Translating an AI application from Lisp to Ada: A case study

NASA Technical Reports Server (NTRS)

Davis, Gloria J.

1991-01-01

A set of benchmarks was developed to test the performance of a newly designed computer executing both Lisp and Ada. Among these was AutoClassII -- a large Artificial Intelligence (AI) application written in Common Lisp. The extraction of a representative subset of this complex application was aided by a Lisp Code Analyzer (LCA). The LCA enabled rapid analysis of the code, putting it in a concise and functionally readable form. An equivalent benchmark was created in Ada through manual translation of the Lisp version. A comparison of the execution results of both programs across a variety of compiler-machine combinations indicate that line-by-line translation coupled with analysis of the initial code can produce relatively efficient and reusable target code.

Veggie Passive Orbital Nutrient Delivery System (PONDS)

NASA Image and Video Library

2018-02-27

Project scientists, place seeds in Veggie Passive Orbital Nutrient Delivery System (PONDS) units inside a laboratory at the Space Station Processing Facility at NASA’s Kennedy Space Center in Florida. Veggie PONDS is a direct follow-on to the Veg-01 and Veg-03 hardware and plant growth validation tests. The primary goal of this newly developed plant growing system, Veggie PONDS, is to demonstrate uniform plant growth. PONDS units have features that are designed to mitigate microgravity effects on water distribution, increase oxygen exchange and provide sufficient room for root zone growth. PONDS is planned for use during Veg-04 and Veg-05 on the International Space Station after the Veggie PONDS Validation flights on SpaceX-14 and OA-9.

Application of computer graphics in the design of custom orthopedic implants.

PubMed

Bechtold, J E

1986-10-01

Implementation of newly developed computer modelling techniques and computer graphics displays and software have greatly aided the orthopedic design engineer and physician in creating a custom implant with good anatomic conformity in a short turnaround time. Further advances in computerized design and manufacturing will continue to simplify the development of custom prostheses and enlarge their niche in the joint replacement market.

Transmission of Hepatitis C Virus From Organ Donors Despite Nucleic Acid Test Screening.

PubMed

Suryaprasad, A; Basavaraju, S V; Hocevar, S N; Theodoropoulos, N; Zuckerman, R A; Hayden, T; Forbi, J C; Pegues, D; Levine, M; Martin, S I; Kuehnert, M J; Blumberg, E A

2015-07-01

Nucleic acid testing (NAT) for hepatitis C virus (HCV) is recommended for screening of organ donors, yet not all donor infections may be detected. We describe three US clusters of HCV transmission from donors at increased risk for HCV infection. Donor's and recipients' medical records were reviewed. Newly infected recipients were interviewed. Donor-derived HCV infection was considered when infection was newly detected after transplantation in recipients of organs from increased risk donors. Stored donor sera and tissue samples were tested for HCV RNA with high-sensitivity quantitative PCR. Posttransplant and pretransplant recipient sera were tested for HCV RNA. Quasispecies analysis of hypervariable region-1 was used to establish genetic relatedness of recipient HCV variants. Each donor had evidence of injection drug use preceding death. Of 12 recipients, 8 were HCV-infected-6 were newly diagnosed posttransplant. HCV RNA was retrospectively detected in stored samples from donor immunologic tissue collected at organ procurement. Phylogenetic analysis showed two clusters of closely related HCV variants from recipients. These investigations identified the first known HCV transmissions from increased risk organ donors with negative NAT screening, indicating very recent donor infection. Recipient informed consent and posttransplant screening for blood-borne pathogens are essential when considering increased risk donors. © Copyright 2015 The American Society of Transplantation and the American Society of Transplant Surgeons.

Rapid genetic counseling and testing in newly diagnosed breast cancer: Patients' and health professionals' attitudes, experiences, and evaluation of effects on treatment decision making.

PubMed

Wevers, Marijke R; Aaronson, Neil K; Bleiker, Eveline M A; Hahn, Daniela E E; Brouwer, Titia; van Dalen, Thijs; Theunissen, Evert B; van Ooijen, Bart; de Roos, Marnix A; Borgstein, Paul J; Vrouenraets, Bart C; Vriens, Eline; Bouma, Wim H; Rijna, Herman; Vente, Johannes P; Kuenen, Marianne A; van der Sanden-Melis, Jacoline; Witkamp, Arjen J; Rutgers, Emiel J Th; Verhoef, Senno; Ausems, Margreet G E M

2017-12-01

Rapid genetic counseling and testing (RGCT) in newly diagnosed high-risk breast cancer (BC) patients may influence surgical treatment decisions. To successfully integrate RGCT in practice, knowledge of professionals', and patients' attitudes toward RGCT is essential. Between 2008 and 2010, we performed a randomized clinical trial evaluating the impact of RGCT. Attitudes toward and experience with RGCT were assessed in 265 patients (at diagnosis, 6- and 12-month follow-up) and 29 medical professionals (before and after the recruitment period). At 6-month follow-up, more patients who had been offered RGCT felt they had been actively involved in treatment decision-making than patients who had been offered usual care (67% vs 48%, P = 0.06). Patients who received DNA-test results before primary surgery reported more often that RGCT influenced treatment decisions than those who received results afterwards (P < 0.01). Eighty-seven percent felt that genetic counseling and testing (GCT) should preferably take place between diagnosis and surgery. Most professionals (72%) agreed that RGCT should be routinely offered to eligible patients. Most patients (74%) and professionals (85%) considered surgeons the most appropriate source for referral. RGCT is viewed as helpful for newly diagnosed high-risk BC patients in choosing their primary surgery and should be offered routinely by surgeons. © 2017 Wiley Periodicals, Inc.

Comparison between Newly Developed and Commercial Inhalant Skin Prick Test Reagents Using In Vivo and In Vitro Methods

PubMed Central

2018-01-01

Background We developed skin prick test (SPT) reagents for common inhalant allergens that reflected the real exposure in Korea. The study aim was to evaluate diagnostic usefulness and allergen potency of our inhalant SPT reagents in comparison with commercial products. Methods We produced eight common inhalant allergen SPT reagents using total extract (Prolagen): Dermatophagoides farinae, Dermatophagoides pteronyssinus, oak, ragweed, mugwort, Humulus japonicus pollens, as well as cat and dog allergens. We compared the newly developed reagents with three commercially available SPT reagents (Allergopharma, Hollister-Stier, Lofarma). We measured total protein concentrations, sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE), major allergen concentration, and biological allergen potencies measured by immunoglobulin E (IgE) immunoblotting and ImmunoCAP inhibition test. Results Diagnostic values of these SPT reagents were expressed as positivity rate and concordance rate of the results from ImmunoCAP allergen-specific IgE test in 94 allergic patients. In vitro analysis showed marked differences in protein concentrations, SDS-PAGE features, major allergen concentrations, and biological allergen potencies of four different SPT reagents. In vivo analysis showed that positive rates and concordance rates of Prolagen® SPT reagents were similar compared to the three commercial SPT reagents. Conclusion The newly developed Prolagen® inhalant SPT reagents are not inferior to the commercially available SPT reagents in allergy diagnosis. PMID:29573248

Research priorities and history of advanced composite compression testing

NASA Technical Reports Server (NTRS)

Baumann, K. J.

1981-01-01

Priorities for standard compression testing research in advanced laminated fibrous composite materials are presented along with a state of the art survey (completed in 1979) including history and commentary on industrial test methods. Historically apparent research priorities and consequent (lack of) progress are supporting evidence for newly derived priorities.

Thermographic inspection and quality assurance of energy conservation procedures for electric buses

NASA Astrophysics Data System (ADS)

Fennell, Henri C.

1998-03-01

Electric buses are one of the solutions for improving air quality in our cities. Many states are adopting 'no new diesel bus' policies, thus increasing the pressure to develop alternative vehicles. The fledgling electric vehicle technology suffers from acceptance problems by major transit authorities due primarily to limited travel range from each battery charge. Utilizing electric buses in the Northeast has the added problem of maintaining an adequate cabin temperature without the availability of heat from a diesel motor. Heating the passenger cabin with an electric heater which draws from the batteries' stored energy significantly reduces the already modest range of these vehicles; therefore, energy conservation measures play an important role in allowing electric vehicles to provide practical transit services. IR thermography, in conjunction with air leakage pressurization diagnostics, has proven to be an excellent tool for developing energy-efficient bus designs as well as a valuable in-service performance testing method. This paper is based on tests performed on several Advanced Vehicle Systems, Inc. electric buses during research performed under Northeast Alternative Vehicle Consortium and Defense Advanced Research Projects Agency grants. The work demonstrates the thermographic methods used and the real- world increased performance of retrofitted and newly designed buses resulting from this initial Portland Transit retrofit project and in a follow-up project to develop a cold weather specification for a new generation of electric buses. Early diagnostic and new-technology follow-up thermographic performance testing was paralleled by energy modeling of early baseline and re-designed vehicles. Modeling and performance data are included. As a result of this research, thermography, air-leakage/pressurization testing, and fog analysis techniques are now being used regularly in research and development and quality assurance procedures by electric bus manufacturers.

Institutionalisation in a Newly Created Private University

ERIC Educational Resources Information Center

Hodson, Peter; Connolly, Michael; Younes, Said

2008-01-01

Purpose: The purpose of this paper is to examine the introduction of a quality assurance system in a new, private university in Syria, and considers the extent to which the theoretical model based on institutional theory and isomorphism is reflected in practice. Design/methodology/approach: A five year longitudinal study which reviews the design,…

75 FR 11483 - Rule Concerning Disclosures Regarding Energy Consumption and Water Use of Certain Home Appliances...

Federal Register 2010, 2011, 2012, 2013, 2014

2010-03-11

... article which consumes, or is designed to consume energy and which, to any significant extent, is...) and has discretion to require comparative information on the label. V. FTC's Advance Notice of... appear on a newly designed EnergyGuide label affixed to the product itself. Finally, the proposed...

Designing Media and ICT Strategies for Non-Formal Education in Eritrea

ERIC Educational Resources Information Center

Murthy, C. S. H. N.

2006-01-01

Designing media and ICT strategies for a newly formed country like Eritrea, which has endured 30 years of armed struggle, leading to massive destruction followed by serial drought, is fraught with numerous constraints: limitation of human resources (e.g. qualified personnel), infrastructure and financial constraints. At the same time, though it…

78 FR 50454 - Entergy Operations, Inc., River Bend Station, Unit 1

Federal Register 2010, 2011, 2012, 2013, 2014

2013-08-19

... containment internal pressure related to the design basis accident specified either in the technical... RBS to continue to use the pre-extended power uprate value of 7.6 psig rather than use the newly... period following a design basis accident. The Need for the Proposed Action The proposed exemption is...

Designing the Next-Generation Chemistry Journal: The Internet Journal of Chemistry.

ERIC Educational Resources Information Center

Bachrach, Steven M.; Burleigh, Darin C.; Krassivine, Anatoli

1998-01-01

Discusses how the journal "Internet Journal of Chemistry" is designed to take advantage of newly available technologies. Describes the development of the concept of an electronic journal, decision-making on the scope and coverage of the journal, financial logistics, and how the journal will be implemented. Includes perspectives on how this new…

Enhancing the Therapy Experience Using Principles of Video Game Design.

PubMed

Folkins, John Wm; Brackenbury, Tim; Krause, Miriam; Haviland, Allison

2016-02-01

This article considers the potential benefits that applying design principles from contemporary video games may have on enhancing therapy experiences. Six principles of video game design are presented, and their relevance for enriching clinical experiences is discussed. The motivational and learning benefits of each design principle have been discussed in the education literature as having positive impacts on student motivation and learning and are related here to aspects of clinical practice. The essential experience principle suggests connecting all aspects of the experience around a central emotion or cognitive connection. The discovery principle promotes indirect learning in focused environments. The risk-taking principle addresses the uncertainties clients face when attempting newly learned skills in novel situations. The generalization principle encourages multiple opportunities for skill transfer. The reward system principle directly relates to the scaffolding of frequent and varied feedback in treatment. Last, the identity principle can assist clients in using their newly learned communication skills to redefine self-perceptions. These principles highlight areas for research and interventions that may be used to reinforce or advance current practice.

Physical Examination Has a Low Yield in Screening for Carpal Tunnel Syndrome

PubMed Central

Dale, Ann Marie; Descatha, Alexis; Coomes, Justin; Franzblau, Alfred; Evanoff, Bradley

2013-01-01

Background Physical examination is often used to screen workers for carpal tunnel syndrome (CTS). In a population of newly-hired workers, we evaluated the yield of such screening. Methods Our study population included 1108 newly-hired workers in diverse industries. Baseline data included a symptom questionnaire, physical exam, and bilateral nerve conduction testing of the median and ulnar nerves; individual results were not shared with the employer. We tested three outcomes: symptoms of CTS, abnormal median nerve conduction, and a case definition of CTS that required both symptoms and median neuropathy. Results Of the exam measures used, only Semmes-Weinstein sensory testing had a sensitivity value above 31%. Positive predictive values were low, and likelihood ratios were all under 5.0 for positive testing and over 0.2 for negative testing. Conclusion Physical examination maneuvers have a low yield for the diagnosis of CTS in workplace surveillance programs and in post-offer, pre-placement screening programs. PMID:21154516

The Pharmacological Heterogeneity of Nepenthone Analogs in Conferring Highly Selective and Potent κ-Opioid Agonistic Activities.

PubMed

Li, Wei; Long, Jian-Dong; Qian, Yuan-Yuan; Long, Yu; Xu, Xue-Jun; Wang, Yu-Jun; Shen, Qing; Wang, Zuo-Neng; Yang, Xi-Cheng; Xiao, Li; Sun, Hong-Peng; Xu, Yu-Long; Chen, Yi-Yi; Xie, Qiong; Wang, Yong-Hui; Shao, Li-Ming; Liu, Jing-Gen; Qiu, Zhui-Bai; Fu, Wei

2017-04-19

To develop novel analgesics with no side effects or less side effects than traditional opioids is highly demanded to treat opioid receptor mediated pain and addiction issues. Recently, κ-opioid receptor (KOR) has been established as an attractive target, although its selective agonists could bear heterogeneous pharmacological activities. In this study, we designed and synthesized two new series of nepenthone derivatives by inserting a spacer (carbonyl) between 6α,14α-endo-ethenylthebaine and the 7α-phenyl substitution of the skeleton and by substituting the 17-N-methyl group with a cyclopropylmethyl group. We performed in vitro tests (binding and functional assays) and molecular docking operations on our newly designed compounds. The results of wet-experimental measures and modeled binding structures demonstrate that these new compounds are selective KOR agonists with nanomolar level affinities. Compound 4 from these new derivatives showed the highest affinity (K i = 0.4 ± 0.1 nM) and the highest selectivity (μ/κ = 339, δ/κ = 2034) toward KOR. The in vivo tests revealed that compound 4 is able to induce stronger (ED 50 = 2.1 mg/kg) and much longer antinociceptive effect than that of the typical KOR agonist U50488H (ED 50 = 4.4 mg/kg). Therefore, compound 4 can be used as a perfect lead compound for future design of potent analgesics acting through KOR.

Combining symmetry breaking and restoration with configuration interaction: A highly accurate many-body scheme applied to the pairing Hamiltonian

NASA Astrophysics Data System (ADS)

Ripoche, J.; Lacroix, D.; Gambacurta, D.; Ebran, J.-P.; Duguet, T.

2017-01-01

Background: Ab initio many-body methods have been developed over the past ten years to address mid-mass nuclei. In their best current level of implementation, their accuracy is of the order of a few percent error on the ground-state correlation energy. Recently implemented variants of these methods are operating a breakthrough in the description of medium-mass open-shell nuclei at a polynomial computational cost while putting state-of-the-art models of internucleon interactions to the test. Purpose: As progress in the design of internucleon interactions is made, and as questions one wishes to answer are refined in connection with increasingly available experimental data, further efforts must be made to tailor many-body methods that can reach an even higher precision for an even larger number of observable quantum states or nuclei. The objective of the present work is to contribute to such a quest by designing and testing a new many-body scheme. Methods: We formulate a truncated configuration-interaction method that consists of diagonalizing the Hamiltonian in a highly truncated subspace of the total N -body Hilbert space. The reduced Hilbert space is generated via the particle-number projected BCS state along with projected seniority-zero two- and four-quasiparticle excitations. Furthermore, the extent by which the underlying BCS state breaks U(1 ) symmetry is optimized in the presence of the projected two- and four-quasiparticle excitations. This constitutes an extension of the so-called restricted variation after projection method in use within the frame of multireference energy density functional calculations. The quality of the newly designed method is tested against exact solutions of the so-called attractive pairing Hamiltonian problem. Results: By construction, the method reproduces exact results for N =2 and N =4 . For N =(8 ,16 ,20 ) , the error in the ground-state correlation energy is less than (0.006%, 0.1%, 0.15%) across the entire range of internucleon coupling defining the pairing Hamiltonian and driving the normal-to-superfluid quantum phase transition. The presently proposed method offers the advantage of automatic access to the low-lying spectroscopy, which it does with high accuracy. Conclusions: The numerical cost of the newly designed variational method is polynomial (N6) in system size. This method achieves unprecedented accuracy for the ground-state correlation energy, effective pairing gap, and one-body entropy as well as for the excitation energy of low-lying states of the attractive pairing Hamiltonian. This constitutes a sufficiently strong motivation to envision its application to realistic nuclear Hamiltonians in view of providing a complementary, accurate, and versatile ab initio description of mid-mass open-shell nuclei in the future.

How Strong and Weak Readers Perform on the Developmental Eye Movement Test (DEM): Norms for Latvian School-Aged Children

ERIC Educational Resources Information Center

Serdjukova, Jelena; Ekimane, Lasma; Valeinis, Janis; Skilters, Jurgis; Krumina, Gunta

2017-01-01

The aim of our study was to determine DEM test performance norms for school-aged children in Latvia, assess how DEM test results correlate with children's reading rates, compare test performance between strong and weak readers. A modified DEM test and a newly developed reading test were administered to 1487 children during a screening survey. Our…

Design of new inhibitors for H5N1 avian influenza using a molecular dynamics simulation

NASA Astrophysics Data System (ADS)

Park, Jin Woo; Jo, Won Ho

2008-03-01

Recently, there has been a growing interest in the treatment of H5N1 avian influenza. One of the most widely used antiviral agents is oseltamivir. However, it has been reported that oseltamivir is not as effective against the neuraminidase subtype N1 as it is against subtypes N2 and N9. In our research we addressed this problem by designing new inhibitors and these altered inhibitor's binding affinities were calculated. In this study, we introduced chemical groups to the existing oseltamivir, so to fit into the newly discovered cavity in the subtype N1. When the binding strengths of the oseltamivir and the newly designed inhibitors for N1 were calculated to examine the drug efficiency through a molecular dynamics simulation, then compared with each other, it was found that one of the designed molecules exhibited a strong binding affinity, with more than twice the binding strength than that of oseltamivir. Since the aforementioned designed inhibitor appears to have the possibility for oral activity according to the criteria of human oral bioavailability, we propose that the inhibitor is a promising antiviral drug for H5N1 avian influenza.

An Investigation of Integrative and Independent Listening Test Tasks in a Computerised Academic English Test

ERIC Educational Resources Information Center

Wei, Wei; Zheng, Ying

2017-01-01

This research provided a comprehensive evaluation and validation of the listening section of a newly introduced computerised test, Pearson Test of English Academic (PTE Academic). PTE Academic contains 11 item types assessing academic listening skills either alone or in combination with other skills. First, task analysis helped identify skills…

Evaluation of a newly designed sandwich enzyme linked immunosorbent assay for the detection of hydatid antigen in serum, urine and cyst fluid for diagnosis of cystic echinococcosis

PubMed Central

Chaya, DR; Parija, Subhash Chandra

2013-01-01

Introduction: Cystic echinococcosis (CE) is a zoonotic disease of humans with variable clinical manifestations. Imaging and immunological methods are currently the mainstay of diagnosis of this disease. Although the immunological tests for detection of anti-echinococcal antibodies have several disadvantages, they are widely being used. Antigen is far more superior than antibody detection test as they can provide a specific parasitic diagnosis. Materials and Methods: A sandwich enzyme linked immunosorbent assay (ELISA) was designed using antibodies to 24 kDa urinary hydatid antigen for the detection of hydatid antigens in urine, serum and cyst fluid specimens. The performance of this novel test was compared with that of other hydatid antibody detection ELISA and enzyme immune transfer blot (EITB) using radiological and surgical confirmation as the gold standard. Results: The antigen detection ELISA showed 100% sensitivity and specificity when tested with cyst fluid. On testing urine and serum, the antigen detection ELISA was found to be more specific than antibody detection ELISA. EITB was found to be the most sensitive and specific test. Conclusions: ELISA using polyclonal antibodies against 24 kDa urinary hydatid protein was moderately sensitive to detect hydatid antigen in serum and urine. Hence polyclonal antibodies to 24 kDa urinary hydatid antigen can be used as an alternative source of antibody to detect hydatid antigen in serum, urine and cyst fluid. In the present study, EITB was found to be highly specific test for detection of hydatid antibodiesin serum. 24 kDa protein was found to be specific and of diagnostic value in CE. PMID:24470996

Testing the Community-Based Learning Collaborative (CBLC) implementation model: a study protocol.

PubMed

Hanson, Rochelle F; Schoenwald, Sonja; Saunders, Benjamin E; Chapman, Jason; Palinkas, Lawrence A; Moreland, Angela D; Dopp, Alex

2016-01-01

High rates of youth exposure to violence, either through direct victimization or witnessing, result in significant health/mental health consequences and high associated lifetime costs. Evidence-based treatments (EBTs), such as Trauma-Focused Cognitive Behavioral Therapy (TF-CBT), can prevent and/or reduce these negative effects, yet these treatments are not standard practice for therapists working with children identified by child welfare or mental health systems as needing services. While research indicates that collaboration among child welfare and mental health services sectors improves availability and sustainment of EBTs for children, few implementation strategies designed specifically to promote and sustain inter-professional collaboration (IC) and inter-organizational relationships (IOR) have undergone empirical investigation. A potential candidate for evaluation is the Community-Based Learning Collaborative (CBLC) implementation model, an adaptation of the Learning Collaborative which includes strategies designed to develop and strengthen inter-professional relationships between brokers and providers of mental health services to promote IC and IOR and achieve sustained implementation of EBTs for children within a community. This non-experimental, mixed methods study involves two phases: (1) analysis of existing prospective quantitative and qualitative quality improvement and project evaluation data collected pre and post, weekly, and monthly from 998 participants in one of seven CBLCs conducted as part of a statewide initiative; and (2) Phase 2 collection of new quantitative and qualitative (key informant interviews) data during the funded study period to evaluate changes in relations among IC, IOR, social networks and the penetration and sustainment of TF-CBT in targeted communities. Recruitment for Phase 2 is from the pool of 998 CBLC participants to achieve a targeted enrollment of n = 150. Study aims include: (1) Use existing quality improvement (weekly/monthly online surveys; pre-post surveys; interviews) and newly collected quantitative (monthly surveys) and qualitative (key informant interviews) data and social network analysis to test whether CBLC strategies are associated with penetration and sustainment of TF-CBT; and (2) Use existing quantitative quality improvement (weekly/monthly on-line surveys; pre/post surveys) and newly collected qualitative (key informant interviews) data and social network analysis to test whether CBLC strategies are associated with increased IOR and IC intensity. The proposed research leverages an on-going, statewide implementation initiative to generate evidence about implementation strategies needed to make trauma-focused EBTs more accessible to children. This study also provides feasibility data to inform an effectiveness trial that will utilize a time-series design to rigorously evaluate the CBLC model as a mechanism to improve access and sustained use of EBTs for children.

Explicit Nonlinear Finite Element Geometric Analysis of Parabolic Leaf Springs under Various Loads

PubMed Central

Kong, Y. S.; Omar, M. Z.; Chua, L. B.; Abdullah, S.

2013-01-01

This study describes the effects of bounce, brake, and roll behavior of a bus toward its leaf spring suspension systems. Parabolic leaf springs are designed based on vertical deflection and stress; however, loads are practically derived from various modes especially under harsh road drives or emergency braking. Parabolic leaf springs must sustain these loads without failing to ensure bus and passenger safety. In this study, the explicit nonlinear dynamic finite element (FE) method is implemented because of the complexity of experimental testing A series of load cases; namely, vertical push, wind-up, and suspension roll are introduced for the simulations. The vertical stiffness of the parabolic leaf springs is related to the vehicle load-carrying capability, whereas the wind-up stiffness is associated with vehicle braking. The roll stiffness of the parabolic leaf springs is correlated with the vehicle roll stability. To obtain a better bus performance, two new parabolic leaf spring designs are proposed and simulated. The stress level during the loadings is observed and compared with its design limit. Results indicate that the newly designed high vertical stiffness parabolic spring provides the bus a greater roll stability and a lower stress value compared with the original design. Bus safety and stability is promoted, as well as the load carrying capability. PMID:24298209

Explicit nonlinear finite element geometric analysis of parabolic leaf springs under various loads.

PubMed

Kong, Y S; Omar, M Z; Chua, L B; Abdullah, S

2013-01-01

This study describes the effects of bounce, brake, and roll behavior of a bus toward its leaf spring suspension systems. Parabolic leaf springs are designed based on vertical deflection and stress; however, loads are practically derived from various modes especially under harsh road drives or emergency braking. Parabolic leaf springs must sustain these loads without failing to ensure bus and passenger safety. In this study, the explicit nonlinear dynamic finite element (FE) method is implemented because of the complexity of experimental testing A series of load cases; namely, vertical push, wind-up, and suspension roll are introduced for the simulations. The vertical stiffness of the parabolic leaf springs is related to the vehicle load-carrying capability, whereas the wind-up stiffness is associated with vehicle braking. The roll stiffness of the parabolic leaf springs is correlated with the vehicle roll stability. To obtain a better bus performance, two new parabolic leaf spring designs are proposed and simulated. The stress level during the loadings is observed and compared with its design limit. Results indicate that the newly designed high vertical stiffness parabolic spring provides the bus a greater roll stability and a lower stress value compared with the original design. Bus safety and stability is promoted, as well as the load carrying capability.

Copper and zinc removal from roof runoff: from research to full-scale adsorber systems.

PubMed

Steiner, M; Boller, M

2006-01-01

Large, uncoated copper and zinc roofs cause environmental problems if their runoff is infiltrated into the underground or discharged into receiving waters. Since source control is not always feasible, barrier systems for efficient copper and zinc removal are recommended in Switzerland. During the last few years, research carried out in order to test the performance of GIH-calcite adsorber filters as a barrier system. Adsorption and mass transport processes were assessed and described in a mathematical model. However, this model is not suitable for practical design, because it does not give explicit access to design parameters such as adsorber diameter and adsorber bed depth. Therefore, for e.g. engineers, an easy to use design guideline for GIH-calcite adsorber systems was developed, mainly based on the mathematical model. The core of this guideline is the design of the depth of the GIH-calcite adsorber layer. The depth is calculated by adding up the GIH depth for sorption equilibrium and the depth for the mass transfer zone (MTZ). Additionally, the arrangement of other adsorber system components such as particle separation and retention volume was considered in the guideline. Investigations of a full-scale adsorber confirm the successful application of this newly developed design guideline for the application of GIH-calcite adsorber systems in practice.

A Safety Run-in and Randomized Phase II Study of Cilengitide Combined with Chemoradiation for Newly Diagnosed Glioblastoma (NABTT 0306)

PubMed Central

Nabors, L. Burt; Mikkelsen, Tom; Hegi, Monika E.; Ye, Xiaubu; Batchelor, Tracy; Lesser, Glenn; Peereboom, David; Rosenfeld, Myrna R.; Olsen, Jeff; Brem, Steve; Fisher, Joy D.; Grossman, Stuart A.

2012-01-01

Background Cilengitide is a selective integrin inhibitor that is well tolerated and has demonstrated biological activity in patients with recurrent malignant glioma. The primary objectives of this randomized phase II trial were to determine safety and efficacy of cilengitide when combined with radiation and temozolomide for newly diagnosed glioblastoma (GBM) and to select a dose for comparative clinical testing. Methods A total of 112 patients were accrued. Eighteen patients received standard RT+TMZ with cilengitide in a safety run-in phase followed by a randomized phase II with ninety-four patients assigned to either 500 or 2000 mg dose groups. The trial was designed to estimate overall survival benefit when compared with the NABTT internal historical control or the published EORTC 26981 data. Results Cilengitide at all doses studied was well tolerated with radiation and temozolomide. The median survival was 19.7 months for all patients, 17.4 months for those receiving the 500 mg dose, 20.8 months for those receiving the 2000mg dose, 30 months for patients with methylated MGMT promoters and 17.4 months for unmethylated patients. For patients ages 70 and younger, the median survival and survival at 24 months was superior to that observed in the EORTC trial (20.7 months vs 14.6 months and 41% vs 27% (p=0.008) respectively). Conclusions Cilengitide is well tolerated when combined with standard chemoradiation and may improve survival for patients newly diagnosed with GBM regardless of MGMT status. From an efficacy and safety standpoint, future trials of this agent in this population should utilize the 2000 mg dose. PMID:22517399

The effects of a video-based education in women with newly diagnosed breast cancer in Singapore.

PubMed

Tan, May Leng; Lee, Kim Hua; Yong, Wei Sean; Rodgers, Cheryl

2018-05-18

The purpose of this study was to evaluate the impact of an educational video among women who were newly diagnosed with breast cancer on knowledge, anxiety, and satisfaction with their surgical decision. A pre-post-test design was used to evaluate knowledge, anxiety, and satisfaction levels with decision-making regarding surgery among women with breast cancer. A purposive sampling strategy was implemented to compare outcomes of newly diagnosed breast cancer women who received standard of care that included breast care nurse counseling sessions and written materials to women who received standard of care plus a supplement educational video. Knowledge and anxiety scores were collected at baseline and 2 weeks post-operatively. Satisfaction with decision (SWD) on the nature of surgery was gathered 2 weeks after surgery. Sixty-two subjects were recruited in a Singapore tertiary cancer center with a cohort of 32 women in the non-video group and 30 women in the video group. There was a statistically significant interaction effect of group and time (p = .008), wherein knowledge increased for both groups, although the increase was steeper for the video group. Both groups had significantly lower anxiety at post-implementation compared to pre-implementation (p < .001). There were no differences in SWD scores in both groups. Use of an additional video-based education significantly increased breast cancer knowledge levels among women in the educational video group. Nurses and healthcare professionals should focus on identifying individual informational needs based on surgical options to provide personalize care and transfer the necessary knowledge in empowering woman's decision-making process on her nature of breast surgery.

Provider Influences on Sperm Banking Outcomes among Adolescent Males Newly Diagnosed with Cancer

PubMed Central

Klosky, James L.; Anderson, L. Elizabeth; Russell, Kathryn M.; Huang, Lu; Zhang, Hui; Schover, Leslie R.; Simmons, Jessica L.; Kutteh, William H.

2017-01-01

Purpose To examine provider communication and sociodemographic factors which associate with sperm banking outcomes in at-risk adolescents newly diagnosed with cancer. Methods A prospective single group quasi-experimental study design was utilized to test the contributions of provider factors on sperm banking outcomes. Medical providers (N=52, 86.5% oncologists) and 99 of their at-risk adolescent patients from eight leading pediatric oncology centers in North America completed questionnaires querying provider factors and patient sperm banking outcomes. Logistic regression with single covariates was utilized to test each provider factor as a potential correlate of the two binary sperm banking study outcomes (collection attempt/no attempt and successful sperm bank/no bank). Multi-covariate logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (CIs) for specified banking outcomes. Results Fertility referral (OR=9.01, 95% CI=2.54–31.90, p<.001) and provider comfort/skills in negotiating barriers to sperm banking with families (OR=1.94, 95% CI=1.03–3.63, p<0.04) were associated with collection attempts. Adolescents who were referred for a specialized fertility consultation were also almost 5 times more likely to successfully bank (OR=4.96, 95% CI=1.54–16.00, p<.01) relative to those who were not. Conclusions Provider training in communicating/managing adolescents and their families about sperm banking, and increasing utilization of fertility preservation referrals, should increase the proportion of at-risk males preserving fertility prior to treatment initiation. Title Registration Clinicaltrials.gov NCT01152268 PMID:27998702

Fears for literacy and numeracy as new nurses fail basic tests.

PubMed

Learner, Sue

2006-08-16

The Nursing and Midwifery Council (NMC) has voiced concern over nurses' poor levels of English and maths after a third of newly qualified nurses failed a basic test set by a hospital as part of anew selection process.

Design and Demonstration of an Advanced Agricultural Feedstock Supply System for Lignocellulosic Bioenergy Production

DOE Office of Scientific and Technical Information (OSTI.GOV)

Clark, Timothy C.; Comer, Kevin S.; Belden, Jr., William S.

2016-04-30

This three-year project developed and demonstrated four innovative, first-of-their-kind pieces of equipment that are aimed at significantly reducing the cost of delivered herbaceous biomass. This equipment included a Self-Propelled Baler (SPB), a Bale Picking Truck (BPT), a Self-Loading Trailer (SLT), and a Heavy Crop Header for harvesting high yielding energy crops. This equipment was designed and fabricated during the first two years of the project and demonstrated on available crops (corn stover, wheat straw, and warm season grasses) across the nation, as available. Operational performance and cost data was collected and analyzed throughout the project to measure the costs ofmore » baseline harvesting (using conventional harvesting equipment) and advanced harvesting with the newly developed equipment. This data revealed that the project met its original goal of developing equipment that is realistically capable of reducing the cost of delivered biomass by $13 per dry ton. Each machine was tested after fabrication and put to the test in one or more commercial harvesting seasons. During these tests, operational flaws were found and fixed through upgrades and improvements. The first new SPB, BPT, and two new SLTs were ready for use during the 2013 harvest season. Since then, over 40 SLTs have been ordered and are currently under fabrication. All of the equipment will be commercially available to the industry as demand increases.« less

Erosion of newly developed CFCs and Be under disruption heat loads

NASA Astrophysics Data System (ADS)

Nakamura, K.; Akiba, M.; Araki, M.; Dairaku, M.; Sato, K.; Suzuki, S.; Yokoyama, K.; Linke, J.; Duwe, R.; Bolt, H.; Roedig, M.

1996-10-01

An evaluation of the erosion under disruption heat loads is very important to the lifetime prediction of divertor armour tiles of next fusion devices such as ITER. In particular, erosion data on CFCs (carbon fiber reinforced composites) and beryllium (Be) as the armour materials is urgently required in the ITER design. For CFCs, high heat flux experiments on the newly developed CFCs with high thermal conductivity have been performed under the heat flux of around 800-2000 MW/m 2 and the pulse length of 2-5 ms in JAERI electron beam irradiation systems (JEBIS). As a result, the weight losses of B 4C doped CFCs after heating were almost same to those of the non doped CFC up to 5 wt% boron content. For Be, we have carried out our first disruption experiments on S65/C grade Be specimens in the Juelich divertor test facility in hot cells (JUDITH) facility as a frame work of the J—EU collaboration. The heating conditions were heat loads of 1250-5000 MW/m 2 for 2-8 ms, and the heated area was 3 × 3 mm 2. As a result, the protuberances of the heated area of Be were observed under the lower heat flux.